NetTable 1. Localizations of S-ketamine-induced Increases (Subanesthetic concentration vs. Baseline) in Regional Cerebral Blood Flow (rCBF). Absolute SPM-analysis (T = 3, k = 600).

 

 

 

Proportion of

 

Proportion of the Region

 

Cluster

 

Maximum Voxel

Lobe

Region

 

Cluster Volume (%)

 

Covered by the Cluster (%)

 

Voxels

p

 

MNI Coordinates

CLUSTER 1

 

 

 

 

 

 

7854

<0.001

 

42

16

-2

Frontal Lobe

Precentral Gyrus

R

2.93

 

5.66

 

230

 

 

 

 

 

 

Inferior Frontal Gyrus

R

40.22

 

67.66

 

3159

 

 

 

 

 

 

Middle Frontal Gyrus

R

19.52

 

21.11

 

1533

 

 

 

 

 

 

Superior Frontal Gyrus

R

4.55

 

6.08

 

357

 

 

 

 

 

Temporal Lobe

Superior Temporal Gyrus

R

2.74

 

4.09

 

215

 

 

 

 

 

Limbic Lobe

Subcallosal Gyrus

R

1.38

 

36.99

 

108

 

 

 

 

 

 

Parahippocampal Gyrus

R

0.76

 

2.96

 

60

 

 

 

 

 

 

Uncus

R

0.87

 

10.46

 

68

 

 

 

 

 

Insula

 

R

7.55

 

27.8

 

593

 

 

 

 

 

Total % of the Cluster

 

80.5

 

 

 

6324

 

 

 

 

 

CLUSTER 2

 

 

 

 

 

 

2497

0.009

 

-54

38

0

Frontal Lobe

Inferior Frontal Gyrus

L

39.89

 

21.58

 

996

 

 

 

 

 

 

Middle Frontal Gyrus

L

4.29

 

1.47

 

107

 

 

 

 

 

 

Superior Frontal Gyrus

L

2.8

 

1.21

 

70

 

 

 

 

 

Insula

 

L

20.42

 

24.02

 

510

 

 

 

 

 

Claustrum

 

L

2.24

 

26.17

 

56

 

 

 

 

 

Total % of the Cluster

 

69.6

 

 

 

1739

 

 

 

 

 

R = Right Hemisphere, L = Left Hemisphere, T = Height Threshold, k = Extend Threshold. Unlocalized proportions were not identifiable, located outside neural tissue or were sized < 50 voxels.