FN Clarivate Analytics Web of Science
VR 1.0
PT J
AU Dziegielewska-Gesiak, S
   Fatyga, E
   Pilot, M
   Wierzgon, A
   Muc-Wierzgon, M
AF Dziegielewska-Gesiak, Sylwia
   Fatyga, Edyta
   Pilot, Magdalena
   Wierzgon, Aleksander
   Muc-Wierzgon, Malgorzata
TI Are There Differences in Gut Microbiome in Patients with Type 2 Diabetes
   Treated by Metformin or Metformin and Insulin?
SO DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
LA English
DT Article
DE gut microbiome; type 2 diabetes; metformin; metformin plus insulin
AB Introduction: Recently, gut microbiota has been described as being involved in the health and diseases of the host, and together with diet and drugs may influence metabolic health. Yet, there is still no answer which type of treatment plays the most important role in the interplay of gut microbiota and type of treatment for type 2 diabetes (T2DM). An attempt was made to answer the question of which factors have the most significant impact on the intestinal microbiome in the context of metformin or metformin+insulin use in treatment of the patients with T2DM. Thus the aim of the study was to compare the gut microbiome profiles of patients with T2DM and two of the most traditional treatment methods.Methods: T2DM patients treated by metformin (Met) and metformin+insulin (Met+Ins), with the treatment duration of 5-10 years were enrolled. Biochemically blood glucose and glycated hemoglobin (HbA1c), lipids and kidney function were investigated and the quantitative and qualitative examination of the fecal intestinal flora were performed through the next-generation sequencing.Results: There were no significant differences in the study of the gut microbiome: the dominant bacterial phyla were Firmicutes and Verrucomicrobia, while Bacteroidetes and Proteobacteria shared smaller proportions in both groups. However, the group Met+Ins had worse metabolic control in terms of blood glucose and HbA1c in comparison with the Met group.Conclusion: As there are no differences in gut microbiome in T2DM patients treated with metformin only or metformin plus insulin, adding insulin in the treatment of T2DM may delay late diabetic complications development.
C1 [Dziegielewska-Gesiak, Sylwia; Fatyga, Edyta; Pilot, Magdalena; Muc-Wierzgon, Malgorzata] Med Univ Siles Katowice, Dept Internal Med Prevent, Katowice, Poland.
   [Wierzgon, Aleksander] Silesian Tech Univ, Fac Energy & Environm Engn, Dept Environm Biotechnol, Gliwice, Poland.
   [Dziegielewska-Gesiak, Sylwia] Med Univ Siles Katowice, Dept Internal Prevent Med, Piekarska 18 st, PL-41902 Katowice, Poland.
C3 Medical University Silesia; Silesian University of Technology; Medical
   University Silesia
RP Dziegielewska-Gesiak, S (通讯作者)，Med Univ Siles Katowice, Dept Internal Prevent Med, Piekarska 18 st, PL-41902 Katowice, Poland.
EM sgesiak@sum.edu.pl
OI Dziegielewska-Gesiak, Sylwia/0000-0003-1019-5959; Muc-Wierzgon,
   Malgorzata/0000-0001-6562-7072
CR Amer Diabet Assoc Professional Pra, 2022, DIABETES CARE, V45, pS125, DOI 10.2337/dc22-S009
   Bielka W, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23010480
   Cai KD, 2022, ENDOCRINE, V76, P294, DOI 10.1007/s12020-022-03002-1
   Cao TTB, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.573891
   Chavez-Carbajal A, 2020, MICROORGANISMS, V8, DOI 10.3390/microorganisms8010094
   Clooney AG, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0148028
   Cosola C, 2019, J NEPHROL, V32, P27, DOI 10.1007/s40620-018-0516-0
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Defeudis G, 2022, EAT WEIGHT DISORD-ST, V27, P2339, DOI 10.1007/s40519-022-01434-2
   DeFronzo RA, 2010, AM J MED, V123, pS38, DOI 10.1016/j.amjmed.2009.12.008
   Deng J, 2018, J CELL MOL MED, V22, P546, DOI 10.1111/jcmm.13342
   Dias AM, 2020, PHARMACOL RES PERSPE, V8, DOI 10.1002/prp2.601
   Doestzada M, 2018, PROTEIN CELL, V9, P432, DOI 10.1007/s13238-018-0547-2
   Fan Y, 2021, NAT REV MICROBIOL, V19, P55, DOI 10.1038/s41579-020-0433-9
   Foretz M, 2019, NAT REV ENDOCRINOL, V15, P569, DOI 10.1038/s41574-019-0242-2
   Gurung M, 2020, EBIOMEDICINE, V51, DOI 10.1016/j.ebiom.2019.11.051
   Ampudia-Blasco FJ, 2021, J DIABETES COMPLICAT, V35, DOI 10.1016/j.jdiacomp.2020.107828
   Klindworth A, 2013, NUCLEIC ACIDS RES, V41, DOI 10.1093/nar/gks808
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Lee SH, 2018, J CLIN MED, V7, DOI 10.3390/jcm7090282
   Lv Y, 2018, J DIABETES RES, V2018, DOI 10.1155/2018/1890978
   Makki K, 2018, CELL HOST MICROBE, V23, P705, DOI 10.1016/j.chom.2018.05.012
   McCreight LJ, 2016, DIABETOLOGIA, V59, P426, DOI 10.1007/s00125-015-3844-9
   Myhrstad MCW, 2020, NUTRIENTS, V12, DOI 10.3390/nu12030859
   Rattelman CR, 2021, DIABETES THER, V12, P581, DOI 10.1007/s13300-020-00993-w
   Rodriguez J, 2018, CURR OPIN CLIN NUTR, V21, P294, DOI 10.1097/MCO.0000000000000468
   Salonen A, 2014, ISME J, V8, P2218, DOI 10.1038/ismej.2014.63
   Sedighi M, 2017, MICROB PATHOGENESIS, V111, P362, DOI 10.1016/j.micpath.2017.08.038
   Sharma A, 2019, CLIN PHARMACOL THER, V106, P317, DOI 10.1002/cpt.1437
   Wang HD, 2020, ACTA DIABETOL, V57, P455, DOI 10.1007/s00592-019-01436-0
   Zhou Z, 2022, FRONT CELL INFECT MI, V12, DOI 10.3389/fcimb.2022.834485
NR 31
TC 1
Z9 1
U1 4
U2 4
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7007
J9 DIABET METAB SYND OB
JI Diabetes Metab. Syndr. Obes.
PY 2022
VL 15
BP 3589
EP 3599
DI 10.2147/DMSO.S377856
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 6N0KH
UT WOS:000889249900001
PM 36426212
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Jones, GR
   Molloy, MP
AF Jones, Georgina R.
   Molloy, Mark P.
TI Metformin, Microbiome and Protection Against Colorectal Cancer
SO DIGESTIVE DISEASES AND SCIENCES
LA English
DT Review
DE Metformin; Colorectal cancer; Microbiome; Chemopreventation; Butyrate;
   Bile acids
ID GUT MICROBIOTA; REDUCED RISK; COLON-CANCER; BILE-ACIDS; PROMOTES;
   GROWTH; CARCINOGENESIS; PREVENTION; GLUCAGON; THERAPY
AB Metformin is widely used as a firstline therapy to improve insulin sensitivity in type 2 diabetes mellitus (T2DM) patients. This is achieved primarily through regulating AMP-activated protein kinase (AMPK)-dependent pathways leading to reduced hepatic gluconeogenesis and improved muscular uptake of glucose. Epidemiological studies first recognized a relationship with metformin use in T2DM patients and reduced colorectal cancer (CRC) risk. Thereafter, metformin has gained wide attention as a candidate CRC chemopreventative agent; however, the molecular mechanisms underlying its gastrointestinal anti-cancer properties appear multi-faceted and are not well understood. An intriguing area of research is the growing evidence of metformin's metabolic juncture with gut microbiota at the intestinal mucosal interface. This review examines the mechanistic evidence which may account for metformin's protection against CRC through interactions between the drug, gut microbiota and the colonic epithelial mucosa.
C1 [Jones, Georgina R.; Molloy, Mark P.] Univ Sydney, Kolling Inst, Northern Clin Sch, Bowel Canc & Biomarker Lab, St Leonards, NSW, Australia.
C3 University of Sydney; Kolling Institute of Medical Research
RP Molloy, MP (通讯作者)，Univ Sydney, Kolling Inst, Northern Clin Sch, Bowel Canc & Biomarker Lab, St Leonards, NSW, Australia.
EM m.molloy@sydney.edu.au
OI Molloy, Mark/0000-0003-4679-5868
FU Bowel Cancer Research Foundation Australia
FX MPM acknowledges support from Bowel Cancer Research Foundation
   Australia.
CR Anisimov VN, 2016, CURR DRUG TARGETS, V17, P439, DOI 10.2174/1389450116666150309113305
   Banerjee P, 2016, J MOL MED, V94, P1397, DOI 10.1007/s00109-016-1455-7
   BAYERDORFFER E, 1995, GUT, V36, P268, DOI 10.1136/gut.36.2.268
   BAYERDORFFER E, 1993, GASTROENTEROLOGY, V104, P145, DOI 10.1016/0016-5085(93)90846-5
   Beisswenger P, 2003, DIABETES METAB, V29, pS95
   Bekusova VV, 2017, CANCER BIOL MED, V14, P100, DOI 10.20892/j.issn.2095-3941.2016.0088
   BONORA E, 1984, CURR MED RES OPIN, V9, P47, DOI 10.1185/03007998409109558
   Bradley MC, 2018, CANCER EPIDEM BIOMAR, V27, P525, DOI 10.1158/1055-9965.EPI-17-0424
   Bryrup T, 2019, DIABETOLOGIA, V62, P1024, DOI 10.1007/s00125-019-4848-7
   Cao HL, 2017, INT J CANCER, V140, P2545, DOI 10.1002/ijc.30643
   Cha JH, 2018, MOL CELL, V71, P606, DOI 10.1016/j.molcel.2018.07.030
   Chan AT, 2010, GASTROENTEROLOGY, V138, P2029, DOI 10.1053/j.gastro.2010.01.057
   Chen JZ, 2019, NUTRIENTS, V11, DOI 10.3390/nu11051026
   Coleman OI, 2018, FRONT IMMUNOL, V8, DOI 10.3389/fimmu.2017.01927
   Coyle C, 2016, ANN ONCOL, V27, P2184, DOI 10.1093/annonc/mdw410
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Donohoe DR, 2012, MOL CELL, V48, P612, DOI 10.1016/j.molcel.2012.08.033
   Eikawa S, 2015, P NATL ACAD SCI USA, V112, P1809, DOI 10.1073/pnas.1417636112
   Evans JMM, 2005, BMJ-BRIT MED J, V330, P1304, DOI 10.1136/bmj.38415.708634.F7
   Flynn C, 2007, MOL CARCINOGEN, V46, P60, DOI 10.1002/mc.20253
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Franciosi M, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0071583
   GIOVANNUCCI E, 1994, ANN MED, V26, P443, DOI 10.3109/07853899409148367
   Graham GG, 2011, CLIN PHARMACOKINET, V50, P81, DOI 10.2165/11534750-000000000-00000
   Higurashi T, 2016, LANCET ONCOL, V17, P475, DOI 10.1016/S1470-2045(15)00565-3
   Hosono K, 2010, MOL CARCINOGEN, V49, P662, DOI 10.1002/mc.20637
   Jemal A, 2011, CA-CANCER J CLIN, V61, P134, DOI [10.3322/caac.20107, 10.3322/caac.20115]
   Katona BW, 2020, GASTROENTEROLOGY, V158, P368, DOI 10.1053/j.gastro.2019.06.047
   Kowall B, 2015, PHARMACOEPIDEM DR S, V24, P865, DOI 10.1002/pds.3823
   Litvak Y, 2018, SCIENCE, V362, P1017, DOI 10.1126/science.aat9076
   Liu TY, 2020, INT J CANCER, V146, P1780, DOI 10.1002/ijc.32563
   Madiraju AK, 2014, NATURE, V510, P542, DOI 10.1038/nature13270
   Maslowski KM, 2019, CLIN EXP IMMUNOL, V197, P193, DOI 10.1111/cei.13329
   Miller RA, 2013, NATURE, V494, P256, DOI 10.1038/nature11808
   Ni J, 2017, NAT REV GASTRO HEPAT, V14, P573, DOI 10.1038/nrgastro.2017.88
   O'Keefe SJD, 2016, NAT REV GASTRO HEPAT, V13, P691, DOI 10.1038/nrgastro.2016.165
   Ocvirk Soren, 2017, Curr Nutr Rep, V6, P315, DOI 10.1007/s13668-017-0219-5
   Pernicova I, 2014, NAT REV ENDOCRINOL, V10, P143, DOI 10.1038/nrendo.2013.256
   Pryor R, 2019, CELL, V178, P1299, DOI 10.1016/j.cell.2019.08.003
   Raufman JP, 2015, CARCINOGENESIS, V36, P1193, DOI 10.1093/carcin/bgv107
   REDDY BS, 1977, CANCER-AM CANCER SOC, V39, P2533, DOI 10.1002/1097-0142(197706)39:6<2533::AID-CNCR2820390634>3.0.CO;2-X
   Rena G, 2017, DIABETOLOGIA, V60, P1577, DOI 10.1007/s00125-017-4342-z
   Saisho Y, 2015, ENDOCR METAB IMMUNE, V15, P196, DOI 10.2174/1871530315666150316124019
   Saus E, 2019, MOL ASPECTS MED, V69, P93, DOI 10.1016/j.mam.2019.05.001
   Sayin SI, 2013, CELL METAB, V17, P225, DOI 10.1016/j.cmet.2013.01.003
   Schulz MD, 2014, NATURE, V514, P508, DOI 10.1038/nature13398
   Sehdev A, 2015, CANCER-AM CANCER SOC, V121, P1071, DOI 10.1002/cncr.29165
   Smiechowski B, 2013, CANCER EPIDEM BIOMAR, V22, P1877, DOI 10.1158/1055-9965.EPI-13-0196
   Spielman LJ, 2018, NEUROCHEM INT, V120, P149, DOI 10.1016/j.neuint.2018.08.005
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Tilg H, 2018, CANCER CELL, V33, P954, DOI 10.1016/j.ccell.2018.03.004
   Tomimoto A, 2008, CANCER SCI, V99, P2136, DOI 10.1111/j.1349-7006.2008.00933.x
   Vancura A, 2018, TRENDS PHARMACOL SCI, V39, P867, DOI 10.1016/j.tips.2018.07.006
   Verdura S, 2019, ONCOIMMUNOLOGY, V8, DOI 10.1080/2162402X.2019.1633235
   Wang SA, 2019, MOL CARCINOGEN, V58, P1155, DOI 10.1002/mc.22999
   WEINBERG ED, 1968, ANN NY ACAD SCI, V148, P587, DOI 10.1111/j.1749-6632.1968.tb27733.x
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Yang YX, 2004, GASTROENTEROLOGY, V127, P1044, DOI 10.1053/j.gastro.2004.07.011
NR 58
TC 11
Z9 12
U1 1
U2 12
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0163-2116
EI 1573-2568
J9 DIGEST DIS SCI
JI Dig. Dis. Sci.
PD MAY
PY 2021
VL 66
IS 5
BP 1409
EP 1414
DI 10.1007/s10620-020-06390-4
EA JUN 2020
PG 6
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA RO2IL
UT WOS:000539843000003
PM 32533543
DA 2023-06-08
ER

PT J
AU Induri, SNR
   Kansara, P
   Thomas, SC
   Xu, FX
   Saxena, D
   Li, X
AF Induri, Sri Nitya Reddy
   Kansara, Payalben
   Thomas, Scott C.
   Xu, Fangxi
   Saxena, Deepak
   Li, Xin
TI The Gut Microbiome, Metformin, and Aging
SO ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY
LA English
DT Review
DE gut microbiome; aging; inflammaging; drug toxicity; metformin
ID TYPE-2 DIABETES-MELLITUS; DENDRITIC CELLS; IMMUNE-RESPONSES; LIFE-SPAN;
   AKKERMANSIA-MUCINIPHILA; INTESTINAL MICROFLORA; EPITHELIAL BARRIER;
   ESCHERICHIA-COLI; LACTIC-ACIDOSIS; C. ELEGANS
AB Metformin has been extensively used for the treatment of type 2 diabetes, and it may also promote healthy aging. Despite its widespread use and versatility, metformin's mechanisms of action remain elusive. The gut typically harbors thousands of bacterial species, and as the concentration of metformin is much higher in the gut as compared to plasma, it is plausible that microbiome-drug-host interactions may influence the functions of metformin. Detrimental perturbations in the aging gut microbiome lead to the activation of the innate immune response concomitant with chronic low-grade inflammation. With the effectiveness of metformin in diabetes and antiaging varying among individuals, there is reason to believe that the gut microbiome plays a role in the efficacy of metformin. Metformin has been implicated in the promotion and maintenance of a healthy gut microbiome and reduces many age-related degenerative pathologies. Mechanistic understanding of metformin in the promotion of a healthy gut microbiome and aging will require a systems-level approach.
C1 [Induri, Sri Nitya Reddy; Kansara, Payalben; Thomas, Scott C.; Xu, Fangxi; Saxena, Deepak; Li, Xin] NYU, Dept Mol Pathobiol, Coll Dent, New York, NY 10010 USA.
   [Saxena, Deepak] NYU, Dept Surg, Sch Med, New York, NY 10016 USA.
C3 New York University; New York University
RP Li, X (通讯作者)，NYU, Dept Mol Pathobiol, Coll Dent, New York, NY 10010 USA.
EM xl15@nyu.edu
FU National Institutes of Health [AG068857]; NYU Mega-Grant Initiative
FX This research project was supported by the National Institutes of Health
   grant AG068857 (D.S., X.L.) and the NYU Mega-Grant Initiative (D.S.,
   X.L.).
CR ABRAMS GD, 1963, LAB INVEST, V12, P355
   Adeyemo MA, 2015, DIABETES OBES METAB, V17, P363, DOI 10.1111/dom.12426
   ALAM M, 1994, SCAND J GASTROENTERO, V29, P445, DOI 10.3109/00365529409096836
   Almeida A, 2021, NAT BIOTECHNOL, V39, P105, DOI 10.1038/s41587-020-0603-3
   Amin S, 2019, BRIT J CLIN PHARMACO, V85, P37, DOI 10.1111/bcp.13780
   Armanios M, 2012, NAT REV GENET, V13, P693, DOI 10.1038/nrg3246
   Babich MM, 1998, AM J MED, V104, P490, DOI 10.1016/S0002-9343(98)00088-6
   Backhed F, 2005, SCIENCE, V307, P1915, DOI 10.1126/science.1104816
   Bailey C, 2004, PRACT DIAB INT, V21, P115, DOI [DOI 10.1002/PDI.606, 10.1002/pdi.606]
   Bailey CJ, 2017, DIABETOLOGIA, V60, P1566, DOI 10.1007/s00125-017-4318-z
   BALL S, 1974, BRIT MED J, V4, P699, DOI 10.1136/bmj.4.5946.699
   Baquero F, 2012, CLIN MICROBIOL INFEC, V18, P2, DOI 10.1111/j.1469-0691.2012.03916.x
   Bartlett JG, 2002, NEW ENGL J MED, V346, P334, DOI 10.1056/NEJMcp011603
   Barzilai N, 2016, CELL METAB, V23, P1060, DOI 10.1016/j.cmet.2016.05.011
   Barzilai N, 2012, DIABETES, V61, P1315, DOI 10.2337/db11-1300
   Bauer PV, 2018, CELL METAB, V27, P101, DOI 10.1016/j.cmet.2017.09.019
   Bauman WA, 2000, DIABETES CARE, V23, P1227, DOI 10.2337/diacare.23.9.1227
   Belizario Jose E, 2018, Exp Suppl, V109, P459, DOI 10.1007/978-3-319-74932-7_13
   Bell S, 2017, BMC NEPHROL, V18, DOI 10.1186/s12882-017-0579-5
   Berg G, 2020, MICROBIOME, V8, DOI 10.1186/s40168-020-00875-0
   Berg RD, 1996, TRENDS MICROBIOL, V4, P430, DOI 10.1016/0966-842X(96)10057-3
   Bouskra D, 2008, NATURE, V456, P507, DOI 10.1038/nature07450
   Bridgeman SC, 2018, DIABETES OBES METAB, V20, P1553, DOI 10.1111/dom.13262
   Bridges HR, 2014, BIOCHEM J, V462, P475, DOI 10.1042/BJ20140620
   Bry L, 1996, SCIENCE, V273, P1380, DOI 10.1126/science.273.5280.1380
   Bryrup T, 2019, DIABETOLOGIA, V62, P1024, DOI 10.1007/s00125-019-4848-7
   Cabreiro F, 2013, CELL, V153, P228, DOI 10.1016/j.cell.2013.02.035
   Cai H, 2020, INT J MOL MED, V45, P715, DOI 10.3892/ijmm.2020.4453
   CALLAGHAN TS, 1980, BRIT MED J, V280, P1214, DOI 10.1136/bmj.280.6225.1214
   Cario E, 2007, GASTROENTEROLOGY, V132, P1359, DOI 10.1053/j.gastro.2007.02.056
   Castro-Nallar E, 2015, PEERJ, V3, DOI 10.7717/peerj.1140
   Chen J, 2017, ELIFE, V6, DOI 10.7554/eLife.31268
   Claesson MJ, 2012, NATURE, V488, P178, DOI 10.1038/nature11319
   Clayton TA, 2009, P NATL ACAD SCI USA, V106, P14728, DOI 10.1073/pnas.0904489106
   Clements SJ, 2018, CRIT REV FOOD SCI, V58, P651, DOI 10.1080/10408398.2016.1211086
   Cone CJ, 2010, ANN PHARMACOTHER, V44, P1655, DOI 10.1345/aph.1P099
   Cools N, 2011, IMMUNOTHERAPY-UK, V3, P1203, DOI [10.2217/IMT.11.110, 10.2217/imt.11.110]
   Corchia A, 2020, CLIN TOXICOL, V58, P375, DOI 10.1080/15563650.2019.1648816
   Crawley D, 2017, BMC CANCER, V17, DOI 10.1186/s12885-017-3458-3
   Csaba G, 2019, ACTA MICROBIOL IMM H, V66, P1, DOI 10.1556/030.65.2018.029
   Cuyas E, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00657
   Cuyas E, 2018, AGING CELL, V17, DOI 10.1111/acel.12772
   De Angelis M, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0076993
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   De Luca F, 2019, CLIN EXP IMMUNOL, V195, P74, DOI 10.1111/cei.13158
   De Palma G, 2010, BMC MICROBIOL, V10, DOI 10.1186/1471-2180-10-63
   Dickson RP, 2015, AM J PHYSIOL-LUNG C, V309, pL1047, DOI 10.1152/ajplung.00279.2015
   Dominguez-Bello MG, 2010, P NATL ACAD SCI USA, V107, P11971, DOI 10.1073/pnas.1002601107
   DUNN CJ, 1995, DRUGS, V49, P721, DOI 10.2165/00003495-199549050-00007
   Duong JK, 2013, CLIN PHARMACOKINET, V52, P373, DOI 10.1007/s40262-013-0046-9
   Durand A, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-017-02458-4
   Eckburg PB, 2005, SCIENCE, V308, P1635, DOI 10.1126/science.1110591
   El-Mir MY, 2000, J BIOL CHEM, V275, P223, DOI 10.1074/jbc.275.1.223
   Elyahu Y, 2019, SCI ADV, V5, DOI 10.1126/sciadv.aaw8330
   Fabbrizzi A, 2019, INTERN EMERG MED, V14, P1241, DOI 10.1007/s11739-019-02208-y
   Faner R, 2017, EUR RESPIR J, V49, DOI 10.1183/13993003.02086-2016
   Fang JQ, 2018, AGING CELL, V17, DOI 10.1111/acel.12765
   Fatt M, 2015, STEM CELL REP, V5, P988, DOI 10.1016/j.stemcr.2015.10.014
   Fernandes A, 2007, J NEUROPATH EXP NEUR, V66, P789, DOI 10.1097/nen.0b013e3181461c74
   Fessler J, 2013, FRONT IMMUNOL, V4, DOI 10.3389/fimmu.2013.00231
   Flores GE, 2014, GENOME BIOL, V15, DOI 10.1186/s13059-014-0531-y
   Fontana L, 2010, SCIENCE, V328, P321, DOI 10.1126/science.1172539
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Foster JA, 2013, TRENDS NEUROSCI, V36, P305, DOI 10.1016/j.tins.2013.01.005
   Franceschi C, 2000, ANN NY ACAD SCI, V908, P244
   Franceschi C, 2014, J GERONTOL A-BIOL, V69, pS4, DOI 10.1093/gerona/glu057
   Frank DN, 2007, P NATL ACAD SCI USA, V104, P13780, DOI 10.1073/pnas.0706625104
   Freedberg DE, 2015, GASTROENTEROLOGY, V149, P883, DOI 10.1053/j.gastro.2015.06.043
   Gadecka A, 2019, NUTRIENTS, V11, DOI 10.3390/nu11061251
   Gantois I, 2006, APPL ENVIRON MICROB, V72, P946, DOI 10.1128/AEM.72.1.946-949.2006
   Garg G, 2017, REJUV RES, V20, P16, DOI 10.1089/rej.2016.1826
   Garigan D, 2002, GENETICS, V161, P1101
   Garinis GA, 2008, NAT CELL BIOL, V10, P1241, DOI 10.1038/ncb1108-1241
   GEBBERS JO, 1989, SCHWEIZ ARCH TIERH, V131, P221
   Geerlings SY, 2018, MICROORGANISMS, V6, DOI 10.3390/microorganisms6030075
   Gevers D, 2012, PLOS BIOL, V10, DOI 10.1371/journal.pbio.1001377
   Gilbert JA, 2015, GENOME BIOL, V16, DOI 10.1186/s13059-015-0664-7
   Gill SR, 2006, SCIENCE, V312, P1355, DOI 10.1126/science.1124234
   GORDON HA, 1961, AM J PHYSIOL, V201, P175, DOI 10.1152/ajplegacy.1961.201.1.175
   Gorjifard S, 2016, J LEUKOCYTE BIOL, V100, P865, DOI 10.1189/jlb.3RI0516-222R
   Goronzy JJ, 2015, J IMMUNOL, V194, P4073, DOI 10.4049/jimmunol.1500046
   Guo YQ, 2020, ENDOCRINOL METAB, V35, P36, DOI 10.3803/EnM.2020.35.1.36
   Hammami R, 2013, CELL MOL LIFE SCI, V70, P2947, DOI 10.1007/s00018-012-1202-3
   Hansen CHF, 2012, DIABETOLOGIA, V55, P2285, DOI 10.1007/s00125-012-2564-7
   Haran JP, 2021, GASTROENTEROLOGY, V160, P507, DOI 10.1053/j.gastro.2020.09.060
   Hardie DG, 2012, NAT REV MOL CELL BIO, V13, P251, DOI 10.1038/nrm3311
   Hayden EC, 2015, NATURE, V522, P265, DOI 10.1038/522265a
   Haynes L, 2009, CURR OPIN IMMUNOL, V21, P414, DOI 10.1016/j.coi.2009.05.009
   Hill DA, 2010, MUCOSAL IMMUNOL, V3, P148, DOI 10.1038/mi.2009.132
   Honda K, 2012, ANNU REV IMMUNOL, V30, P759, DOI 10.1146/annurev-immunol-020711-074937
   Hu QC, 2020, CELL DEATH DIS, V11, DOI 10.1038/s41419-020-03126-0
   Huang S, 2020, MSYSTEMS, V5, DOI 10.1128/mSystems.00630-19
   HUSEBYE E, 1994, DIGEST DIS SCI, V39, P946, DOI 10.1007/BF02087542
   Ianiro G, 2016, GUT, V65, P1906, DOI 10.1136/gutjnl-2016-312297
   Imhann F, 2016, GUT, V65, P740, DOI 10.1136/gutjnl-2015-310376
   Iwasaki A, 1999, J EXP MED, V190, P229, DOI 10.1084/jem.190.2.229
   Jackson MA, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-018-05184-7
   Jakobsson HE, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009836
   Janarthanan S, 2012, AM J GASTROENTEROL, V107, P1001, DOI 10.1038/ajg.2012.179
   Jernberg C, 2007, ISME J, V1, P56, DOI 10.1038/ismej.2007.3
   Jin CY, 2011, CELL METAB, V14, P161, DOI 10.1016/j.cmet.2011.07.001
   JOHNSON HK, 1968, ARCH INTERN MED, V122, P367, DOI 10.1001/archinte.122.4.367
   Kaddurah-Daouk R, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0025482
   Kajbaf F, 2013, BMC PHARMACOL TOXICO, V14, DOI 10.1186/2050-6511-14-22
   Kamada N, 2013, NAT IMMUNOL, V14, P685, DOI 10.1038/ni.2608
   KELLY CP, 1994, NEW ENGL J MED, V330, P257, DOI 10.1056/NEJM199401273300406
   Kelsall BL, 2005, IMMUNOL REV, V206, P132, DOI 10.1111/j.0105-2896.2005.00292.x
   Kennedy BK, 2014, CELL, V159, P708, DOI 10.1016/j.cell.2014.10.039
   Kho ZY, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.01835
   Kim S, 2018, GERONTOLOGY, V64, P513, DOI 10.1159/000490615
   Klement RJ, 2016, ONCOGENESIS, V5, DOI 10.1038/oncsis.2016.2
   Konturek PC, 2016, J PHYSIOL PHARMACOL, V67, P859
   Kovtonyuk LV, 2016, FRONT IMMUNOL, V7, DOI 10.3389/fimmu.2016.00502
   Kruse JA, 2001, J EMERG MED, V20, P267, DOI 10.1016/S0736-4679(00)00320-6
   Kuang YC, 2020, BIOGERONTOLOGY, V21, P13, DOI 10.1007/s10522-019-09838-x
   Kuilman T, 2010, GENE DEV, V24, P2463, DOI 10.1101/gad.1971610
   Kulkarni AS, 2020, CELL METAB, V32, P15, DOI 10.1016/j.cmet.2020.04.001
   Kumar A, 2007, EMBO J, V26, P4457, DOI 10.1038/sj.emboj.7601867
   Lederberg J, 2001, SCIENTIST, V15, P8
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Lee N, 2017, EXP MOL MED, V49, DOI 10.1038/emm.2017.36
   Ley RE, 2006, CELL, V124, P837, DOI 10.1016/j.cell.2006.02.017
   Li XY, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0146152
   Liu JH, 2019, AGING-US, V11, P741, DOI 10.18632/aging.101781
   Lopez-Otin C, 2013, CELL, V153, P1194, DOI 10.1016/j.cell.2013.05.039
   Macaulay R, 2013, AGE, V35, P563, DOI 10.1007/s11357-012-9381-2
   Macfarlane S, 2003, P NUTR SOC, V62, P67, DOI 10.1079/PNS2002207
   Macpherson AJ, 2004, NAT REV IMMUNOL, V4, P478, DOI 10.1038/nri1373
   Madiraju AK, 2014, NATURE, V510, P542, DOI 10.1038/nature13270
   Maier L, 2018, NATURE, V555, P623, DOI 10.1038/nature25979
   Mair W, 2008, ANNU REV BIOCHEM, V77, P727, DOI 10.1146/annurev.biochem.77.061206.171059
   Marchesi JR, 2015, MICROBIOME, V3, DOI 10.1186/s40168-015-0094-5
   Marin L, 2015, BIOMED RES INT-UK, V2015, DOI 10.1155/2015/905215
   Maruvada P, 2017, CELL HOST MICROBE, V22, P589, DOI 10.1016/j.chom.2017.10.005
   Maurice CF, 2013, CELL, V152, P39, DOI 10.1016/j.cell.2012.10.052
   Maynard C, 2018, SUBCELL BIOCHEM, V90, P351, DOI 10.1007/978-981-13-2835-0_12
   Mazokopakis EE, 2012, DIABETES RES CLIN PR, V97, P359, DOI 10.1016/j.diabres.2012.06.001
   Megias J, 2012, STEM CELLS, V30, P1486, DOI 10.1002/stem.1110
   Methe BA, 2012, NATURE, V486, P215, DOI 10.1038/nature11209
   Miralles-Linares F, 2012, DIABETES CARE, V35, pE21, DOI 10.2337/dc11-2306
   Mitroulis I, 2018, J INNATE IMMUN, V10, P365, DOI 10.1159/000489406
   Moiseeva O, 2013, AGING CELL, V12, P489, DOI 10.1111/acel.12075
   Momose Y, 2008, ANTON LEEUW INT J G, V94, P165, DOI 10.1007/s10482-008-9222-6
   Montandon SA, 2017, GENES-BASEL, V8, DOI 10.3390/genes8100250
   Moon MK, 2017, DIABETES METAB J, V41, P357, DOI 10.4093/dmj.2017.41.5.357
   Moskalev AA, 2013, AGEING RES REV, V12, P661, DOI 10.1016/j.arr.2012.02.001
   Motta JP, 2021, NAT REV GASTRO HEPAT, V18, P314, DOI 10.1038/s41575-020-00397-y
   Muller CA, 2005, CELL MOL LIFE SCI, V62, P1297, DOI 10.1007/s00018-005-5034-2
   Mussell M, 2008, J PSYCHOSOM RES, V64, P605, DOI 10.1016/j.jpsychores.2008.02.019
   Na HJ, 2018, BIOCHEM BIOPH RES CO, V498, P18, DOI 10.1016/j.bbrc.2018.02.191
   Nammour Fadel E, 2003, Endocr Pract, V9, P307
   Nava GM, 2011, GUT MICROBES, V2, P99, DOI 10.4161/gmic.2.2.15416
   Nayfach S, 2021, NAT BIOTECHNOL, V39, P499, DOI 10.1038/s41587-020-0718-6
   Neish AS, 2009, GASTROENTEROLOGY, V136, P65, DOI 10.1053/j.gastro.2008.10.080
   Neumann B, 2019, CELL STEM CELL, V25, P473, DOI 10.1016/j.stem.2019.08.015
   Newman JC, 2016, J GERONTOL A-BIOL, V71, P1424, DOI 10.1093/gerona/glw149
   Niemeyer-van der Kolk T, 2018, BRIT J CLIN PHARMACO, V84, P2178, DOI 10.1111/bcp.13662
   Nijhout HF, 2004, J BIOL CHEM, V279, P55008, DOI 10.1074/jbc.M410818200
   Noren Hooten N, 2016, AGING CELL, V15, P572, DOI 10.1111/acel.12469
   Onken B, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0008758
   Pamer EG, 2007, NAT IMMUNOL, V8, P1173, DOI 10.1038/ni1526
   Pasquel FJ, 2015, AM J MED SCI, V349, P263, DOI 10.1097/MAJ.0b013e3182a562b7
   Pedersen HK, 2016, NATURE, V535, P376, DOI 10.1038/nature18646
   Peniche AG, 2018, ANAEROBE, V54, P83, DOI 10.1016/j.anaerobe.2018.07.011
   Perry RJ, 2016, NATURE, V534, P213, DOI 10.1038/nature18309
   Peterson LW, 2014, NAT REV IMMUNOL, V14, P141, DOI 10.1038/nri3608
   Pickard JM, 2017, IMMUNOL REV, V279, P70, DOI 10.1111/imr.12567
   Pryor R, 2019, CELL, V178, P1299, DOI 10.1016/j.cell.2019.08.003
   Ragonnaud E, 2021, IMMUN AGEING, V18, DOI 10.1186/s12979-020-00213-w
   ROBERT A, 1977, PROSTAGLANDINS, V14, P333, DOI 10.1016/0090-6980(77)90178-2
   Round JL, 2009, NAT REV IMMUNOL, V9, P313, DOI 10.1038/nri2515
   Safak B, 2020, MICROB PATHOGENESIS, V139, DOI 10.1016/j.micpath.2019.103853
   SAVAGE DC, 1977, ANNU REV MICROBIOL, V31, P107, DOI 10.1146/annurev.mi.31.100177.000543
   Scepanovic P, 2019, MICROBIOME, V7, DOI 10.1186/s40168-019-0747-x
   Schamberger GP, 2002, J FOOD PROTECT, V65, P1381, DOI 10.4315/0362-028X-65.9.1381
   Schumacher B, 2008, PLOS GENET, V4, DOI 10.1371/journal.pgen.1000161
   Sedighi M, 2017, MICROB PATHOGENESIS, V111, P362, DOI 10.1016/j.micpath.2017.08.038
   Shen CL, 2011, IMMUNOL LETT, V138, P144, DOI 10.1016/j.imlet.2011.04.002
   Shen XJ, 2010, GUT MICROBES, V1, P138, DOI 10.4161/gmic.1.3.12360
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Shintouo CM, 2020, EXP GERONTOL, V141, DOI 10.1016/j.exger.2020.111079
   Sica A, 2019, CELL STRESS, V3, P284, DOI 10.15698/cst2019.09.197
   Smith CK, 2018, J LEUKOCYTE BIOL, V104, P701, DOI 10.1002/JLB.4RI0418-151R
   Sommer F, 2013, NAT REV MICROBIOL, V11, P227, DOI 10.1038/nrmicro2974
   Sorg JA, 2008, J BACTERIOL, V190, P2505, DOI 10.1128/JB.01765-07
   Soukas AA, 2019, TRENDS ENDOCRIN MET, V30, P745, DOI 10.1016/j.tem.2019.07.015
   Stavropoulou E, 2019, CRIT REV FOOD SCI, V59, P537, DOI 10.1080/10408398.2017.1379469
   Sun CN, 2019, SAUDI PHARM J, V27, P1146, DOI 10.1016/j.jsps.2019.09.011
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Suzuki K, 2010, IMMUNITY, V33, P71, DOI 10.1016/j.immuni.2010.07.003
   Svare Anders, 2009, Cases J, V2, P156, DOI 10.1186/1757-1626-2-156
   Szewczuk M, 2020, MOL BIOL REP, V47, P9075, DOI 10.1007/s11033-020-05900-x
   Tannock GW, 1999, ANTON LEEUW INT J G, V76, P265, DOI 10.1023/A:1002038308506
   Tilg H, 2014, GUT, V63, P1513, DOI 10.1136/gutjnl-2014-306928
   Tomas-Loba A, 2008, CELL, V135, P609, DOI 10.1016/j.cell.2008.09.034
   Toor D, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20102432
   Toward RE, 2012, GUT MICROBES, V3, P57, DOI 10.4161/gmic.19411
   Turacli ID, 2018, HUM EXP TOXICOL, V37, P909, DOI 10.1177/0960327117737145
   Turacli ID, 2018, BIOCHIMIE, V154, P62, DOI 10.1016/j.biochi.2018.08.002
   Turnbaugh PJ, 2007, NATURE, V449, P804, DOI 10.1038/nature06244
   Uejima M, 1996, MICROBIOL IMMUNOL, V40, P553, DOI 10.1111/j.1348-0421.1996.tb01108.x
   Ursell LK, 2012, J ALLERGY CLIN IMMUN, V129, P1204, DOI 10.1016/j.jaci.2012.03.010
   Vallianou NG, 2019, HORM-INT J ENDOCRINO, V18, P141, DOI 10.1007/s42000-019-00093-w
   van Nood E, 2013, NEW ENGL J MED, V368, P2145, DOI [10.1056/NEJMoa1205037, 10.1056/NEJMc1303919]
   Vecchio S, 2014, CLIN TOXICOL, V52, P129, DOI 10.3109/15563650.2013.860985
   Verstraelen H, 2008, Verh K Acad Geneeskd Belg, V70, P147
   Vieira SM, 2018, SCIENCE, V359, P1156, DOI 10.1126/science.aar7201
   Vila AV, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-019-14177-z
   Viollet B, 2012, CLIN SCI, V122, P253, DOI 10.1042/CS20110386
   Wagstaff Antona J, 2004, Treat Endocrinol, V3, P327, DOI 10.2165/00024677-200403050-00008
   Wallace BD, 2010, SCIENCE, V330, P831, DOI 10.1126/science.1191175
   Wang GS, 2019, J INTENSIVE CARE MED, V34, P863, DOI 10.1177/0885066618793385
   Wang YW, 2017, DRUG DES DEV THER, V11, P2421, DOI 10.2147/DDDT.S141675
   Weaver LK, 2019, JCI INSIGHT, V4, DOI 10.1172/jci.insight.124370
   Wei B, 2021, AM J PHYSIOL-ENDOC M, V320, pE113, DOI 10.1152/ajpendo.00471.2020
   Whitman WB, 1998, P NATL ACAD SCI USA, V95, P6578, DOI 10.1073/pnas.95.12.6578
   Wilmanski T, 2021, NAT METAB, V3, P274, DOI 10.1038/s42255-021-00348-0
   Wilson ID, 2017, TRANSL RES, V179, P204, DOI 10.1016/j.trsl.2016.08.002
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Xie Y, 2014, ONCOL LETT, V8, P1993, DOI 10.3892/ol.2014.2466
   Xu J, 2003, SCIENCE, V299, P2074, DOI 10.1126/science.1080029
   Yanez A, 2013, EUR J IMMUNOL, V43, P2526, DOI 10.1002/eji.201343833
   Yatsunenko T, 2012, NATURE, V486, P222, DOI 10.1038/nature11053
   Yi G, 2013, INT J ONCOL, V43, P1503, DOI 10.3892/ijo.2013.2077
   Yoshii K, 2019, FRONT NUTR, V6, DOI 10.3389/fnut.2019.00048
   Yu T, 2017, ONCOGENESIS, V6, DOI 10.1038/oncsis.2017.28
   Zheng DP, 2020, CELL RES, V30, P492, DOI 10.1038/s41422-020-0332-7
   Zhou GC, 2001, J CLIN INVEST, V108, P1167, DOI 10.1172/JCI200113505
   Zhou ZY, 2016, ACTA PHARMACOL SIN, V37, P1063, DOI 10.1038/aps.2016.21
   Zimmermann M, 2019, NATURE, V570, P462, DOI 10.1038/s41586-019-1291-3
NR 230
TC 12
Z9 12
U1 27
U2 44
PU ANNUAL REVIEWS
PI PALO ALTO
PA 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0139 USA
SN 0362-1642
EI 1545-4304
J9 ANNU REV PHARMACOL
JI Annu. Rev. Pharmacol. Toxicol.
PY 2022
VL 62
BP 85
EP 108
DI 10.1146/annurev-pharmtox-051920-093829
PG 24
WC Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Toxicology
GA 0X7SV
UT WOS:000789902300005
PM 34449247
HC Y
HP N
DA 2023-06-08
ER

PT J
AU McCreight, LJ
   Bailey, CJ
   Pearson, ER
AF McCreight, Laura J.
   Bailey, Clifford J.
   Pearson, Ewan R.
TI Metformin and the gastrointestinal tract
SO DIABETOLOGIA
LA English
DT Review
DE Bile acids; DPP-4; GLP-1; Gut/intestine; Lactate; Metformin; Microbiome;
   OCT1; Review; Serotonin; Uptake
ID GLUCAGON-LIKE PEPTIDE-1; CATION TRANSPORTER 1; DIPEPTIDYL PEPTIDASE-4
   ACTIVITY; MEMBRANE MONOAMINE TRANSPORTER; TYPE-2 DIABETES-MELLITUS;
   CACO-2 CELL MONOLAYERS; GUT MICROBIOTA; GLUCOSE CONTROL; CLINICAL
   PHARMACOKINETICS; GLYCEMIC RESPONSE
AB Metformin is an effective agent with a good safety profile that is widely used as a first-line treatment for type 2 diabetes, yet its mechanisms of action and variability in terms of efficacy and side effects remain poorly understood. Although the liver is recognised as a major site of metformin pharmacodynamics, recent evidence also implicates the gut as an important site of action. Metformin has a number of actions within the gut. It increases intestinal glucose uptake and lactate production, increases GLP-1 concentrations and the bile acid pool within the intestine, and alters the microbiome. A novel delayed-release preparation of metformin has recently been shown to improve glycaemic control to a similar extent to immediate-release metformin, but with less systemic exposure. We believe that metformin response and tolerance is intrinsically linked with the gut. This review examines the passage of metformin through the gut, and how this can affect the efficacy of metformin treatment in the individual, and contribute to the side effects associated with metformin intolerance.
C1 [McCreight, Laura J.; Pearson, Ewan R.] Univ Dundee, Ninewells Hosp, Sch Med, Pearson Grp,Div Cardiovasc & Diabet Med, Mailbox 12,Level 5, Dundee DD1 9SY, Scotland.
   [Bailey, Clifford J.] Aston Univ, Sch Life & Hlth Sci, Birmingham B4 7ET, W Midlands, England.
C3 University of Dundee; Aston University
RP Pearson, ER (通讯作者)，Univ Dundee, Ninewells Hosp, Sch Med, Pearson Grp,Div Cardiovasc & Diabet Med, Mailbox 12,Level 5, Dundee DD1 9SY, Scotland.
EM e.z.pearson@dundee.ac.uk
OI Bailey, Clifford J/0000-0002-6998-6811; Pearson,
   Ewan/0000-0001-9237-8585
FU Wellcome Trust New Investigator Award
FX This work is funded by the Wellcome Trust New Investigator Award,
   awarded to ERP.
CR Ait-Omar A, 2011, DIABETES, V60, P2598, DOI 10.2337/db10-1740
   Bailey C, 2004, PRACT DIAB INT, V21, P115, DOI [DOI 10.1002/PDI.606, 10.1002/pdi.606]
   Bailey CJ, 2008, DIABETOLOGIA, V51, P1552, DOI 10.1007/s00125-008-1053-5
   BAILEY CJ, 1994, BRIT J PHARMACOL, V112, P671, DOI 10.1111/j.1476-5381.1994.tb13128.x
   BAILEY CJ, 1989, DIABETES CARE, V12, P553, DOI 10.2337/diacare.12.8.553
   BAILEY CJ, 1992, BRIT J PHARMACOL, V105, P1009, DOI 10.1111/j.1476-5381.1992.tb09093.x
   Beysen C, 2012, DIABETOLOGIA, V55, P432, DOI 10.1007/s00125-011-2382-3
   Burton Jeffrey H, 2015, J Diabetes Sci Technol, V9, P808, DOI 10.1177/1932296815577425
   Buse JB, 2016, DIABETES CARE, V39, P198, DOI 10.2337/dc15-0488
   Capitanio S, 2015, WORLD J RADIOL, V7, P57, DOI 10.4329/wjr.v7.i3.57
   Carter D, 2003, DIABETES OBES METAB, V5, P120, DOI 10.1046/j.1463-1326.2003.00252.x
   Carter D, 2002, DIABETES OBES METAB, V4, P424, DOI 10.1046/j.1463-1326.2002.00223.x
   CASPARY WF, 1977, DIABETOLOGIA, V13, P187, DOI 10.1007/BF01219698
   Chen SN, 2013, CURR DRUG METAB, V14, P1070, DOI 10.2174/1389200214666131211153933
   Christensen MM, 2015, PHARMACOGENET GENOM, V25, P48, DOI 10.1097/FPC.0000000000000105
   Christensen MMH, 2011, PHARMACOGENET GENOM, V21, P837, DOI 10.1097/FPC.0b013e32834c0010
   Christensen MMH, 2015, EUR J CLIN PHARMACOL, V71, P691, DOI 10.1007/s00228-015-1853-8
   Cubeddu LX, 2000, N-S ARCH PHARMACOL, V361, P85, DOI 10.1007/s002109900152
   Cuthbertson J, 2009, DIABETIC MED, V26, P649, DOI 10.1111/j.1464-5491.2009.02748.x
   Davidson J, 2004, BR J DIABETES VASC D, V4, P273, DOI DOI 10.1177/14746514040040041101
   Davis TME, 2001, BRIT J CLIN PHARMACO, V52, P137, DOI 10.1046/j.0306-5251.2001.01423.x
   Duca FA, 2015, NAT MED, V21, P506, DOI 10.1038/nm.3787
   Dujic T, 2015, DIABETES, V64, P1786, DOI 10.2337/db14-1388
   Engel K, 2005, MOL PHARMACOL, V68, P1397, DOI 10.1124/mol.105.016832
   Engel K, 2004, J BIOL CHEM, V279, P50042, DOI 10.1074/jbc.M407913200
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Fadini GP, 2012, DIABETES OBES METAB, V14, P518, DOI 10.1111/j.1463-1326.2011.01550.x
   Firneisz G, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0012226
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Gambhir SS, 2002, NAT REV CANCER, V2, P683, DOI 10.1038/nrc882
   Gontier E, 2008, EUR J NUCL MED MOL I, V35, P95, DOI 10.1007/s00259-007-0563-6
   Gorboulev V, 2012, DIABETES, V61, P187, DOI 10.2337/db11-1029
   Graham GG, 2011, CLIN PHARMACOKINET, V50, P81, DOI 10.2165/11534750-000000000-00000
   Green BD, 2006, EUR J PHARMACOL, V547, P192, DOI 10.1016/j.ejphar.2006.07.043
   Han TX, 2015, J PHARMACOL EXP THER, V352, P519, DOI 10.1124/jpet.114.220350
   Han T, 2013, MOL PHARMACOL, V84, P182, DOI 10.1124/mol.112.084517
   Hinke SA, 2002, BIOCHEM BIOPH RES CO, V291, P1302, DOI 10.1006/bbrc.2002.6607
   Hur KY, 2015, DIABETES METAB J, V39, P198, DOI 10.4093/dmj.2015.39.3.198
   Innzucchi SE, 2014, JAMA-J AM MED ASSOC, V312, P2668
   Inzucchi SE, 2015, DIABETOLOGIA, V58, P429, DOI 10.1007/s00125-014-3460-0
   JACKSON RA, 1987, DIABETES, V36, P632, DOI 10.2337/diabetes.36.5.632
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kim MH, 2014, J ENDOCRINOL, V220, P117, DOI 10.1530/JOE-13-0381
   Koehler MR, 1997, CYTOGENET CELL GENET, V79, P198, DOI 10.1159/000134720
   Koepsell H, 2004, PFLUG ARCH EUR J PHY, V447, P666, DOI 10.1007/s00424-003-1089-9
   LALAU JD, 1995, DIABETES CARE, V18, P779, DOI 10.2337/diacare.18.6.779
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Lee N, 2014, J BIOL CHEM, V289, P27055, DOI 10.1074/jbc.M114.570564
   Lien F, 2014, J CLIN INVEST, V124, P1037, DOI 10.1172/JCI68815
   Lindsay JR, 2005, DIABETIC MED, V22, P654, DOI 10.1111/j.1464-5491.2005.01461.x
   Madiraju AK, 2014, NATURE, V510, P542, DOI 10.1038/nature13270
   Mannucci E, 2001, DIABETES CARE, V24, P489, DOI 10.2337/diacare.24.3.489
   Marathe PH, 2000, BRIT J CLIN PHARMACO, V50, P325
   Migoya EM, 2010, CLIN PHARMACOL THER, V88, P801, DOI 10.1038/clpt.2010.184
   Misbin RI, 1998, NEW ENGL J MED, V338, P265, DOI 10.1056/NEJM199801223380415
   Mulherin AJ, 2011, ENDOCRINOLOGY, V152, P4610, DOI 10.1210/en.2011-1485
   Muller J, 2005, BIOCHEM PHARMACOL, V70, P1851, DOI 10.1016/j.bcp.2005.09.011
   Naftalin Richard J, 2014, F1000Res, V3, P304, DOI 10.12688/f1000research.5934.1
   Napolitano A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100778
   Oh JR, 2010, AM J ROENTGENOL, V195, P1404, DOI 10.2214/AJR.10.4663
   PENICAUD L, 1989, BIOCHEM J, V262, P881, DOI 10.1042/bj2620881
   Proctor WR, 2008, DRUG METAB DISPOS, V36, P1650, DOI 10.1124/dmd.107.020180
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Roder PV, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0089977
   Sakar Y, 2010, J PHYSIOL PHARMACOL, V61, P301
   Scarpello JHB, 1998, DIABETIC MED, V15, P651, DOI 10.1002/(SICI)1096-9136(199808)15:8<651::AID-DIA628>3.0.CO;2-A
   Scheen AJ, 1996, CLIN PHARMACOKINET, V30, P359, DOI 10.2165/00003088-199630050-00003
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Stage TB, 2015, CLIN PHARMACOKINET, V54, P811, DOI 10.1007/s40262-015-0270-6
   Stepensky D, 2002, DRUG METAB DISPOS, V30, P861, DOI 10.1124/dmd.30.8.861
   Thomas C, 2009, CELL METAB, V10, P167, DOI 10.1016/j.cmet.2009.08.001
   Thondam SK, 2012, DIABETIC MED, V29, pE205, DOI 10.1111/j.1464-5491.2012.03675.x
   Tilg H, 2014, GUT, V63, P1513, DOI 10.1136/gutjnl-2014-306928
   TUCKER GT, 1981, BRIT J CLIN PHARMACO, V12, P235
   Turner RC, 1998, LANCET, V352, P854, DOI 10.1016/s0140-6736(98)07037-8
   Vardarli I, 2014, DIABETES, V63, P663, DOI 10.2337/db13-0805
   Walker J, 2005, BIOCHEM J, V385, P485, DOI 10.1042/BJ20040694
   WILCOCK C, 1994, XENOBIOTICA, V24, P49, DOI 10.3109/00498259409043220
   Wu TZ, 2014, DIABETES RES CLIN PR, V106, pE3, DOI 10.1016/j.diabres.2014.08.004
   Yasuda N, 2002, BIOCHEM BIOPH RES CO, V298, P779, DOI 10.1016/S0006-291X(02)02565-2
   Yee SW, 2015, J PHARMACOKINET PHAR, V42, P463, DOI 10.1007/s10928-015-9436-y
   Yi FH, 2008, ENDOCRINOLOGY, V149, P2341, DOI 10.1210/en.2007-1142
   Zema MJ, 2012, CORE EVID, V7, P61, DOI 10.2147/CE.S26725
   Zhang XY, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0071108
   Zhou KX, 2014, LANCET DIABETES ENDO, V2, P481, DOI 10.1016/S2213-8587(14)70050-6
   Zhou KX, 2009, DIABETES, V58, P1434, DOI 10.2337/db08-0896
   Zhou MY, 2007, DRUG METAB DISPOS, V35, P1956, DOI 10.1124/dmd.107.015495
NR 87
TC 368
Z9 386
U1 13
U2 112
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0012-186X
EI 1432-0428
J9 DIABETOLOGIA
JI Diabetologia
PD MAR
PY 2016
VL 59
IS 3
BP 426
EP 435
DI 10.1007/s00125-015-3844-9
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DN8BC
UT WOS:000377302900005
PM 26780750
OA Green Published, hybrid, Green Accepted
HC Y
HP N
DA 2023-06-08
ER

PT J
AU Seicaru, EM
   Ilie, IRP
   Catinean, A
   Craciun, AM
   Ghervan, C
AF Seicaru, Elena Maria
   Ilie, Ioana Rada Popa
   Catinean, Adrian
   Craciun, Alexandra Marioara
   Ghervan, Cristina
TI Enhancing Metformin Effects by Adding Gut Microbiota Modulators to
   Ameliorate the Metabolic Status of Obese, Insulin-Resistant Hosts
SO JOURNAL OF GASTROINTESTINAL AND LIVER DISEASES
LA English
DT Review
DE intestinal microbiota; metformin; probiotics; prebiotics; obesity;
   insulin resistance metabolic syndrome
ID TYPE-2 DIABETES-MELLITUS; CHAIN FATTY-ACIDS; GLUCAGON-LIKE PEPTIDE-1;
   BODY-MASS INDEX; INTESTINAL MICROBIOTA; SCUTELLARIA-BAICALENSIS;
   AKKERMANSIA-MUCINIPHILA; DIETARY FIBER; OPEN-LABEL; PROBIOTICS
AB Obesity is a systemic disease and represents one of the leading causes of death worldwide by constituting the main risk factor for a series of non-communicable diseases such as type 2 diabetes mellitus (T2DM), cardiovascular diseases and dyslipidemia. Lifestyle interventions have been attempting to prevent T2DM and obesity but are difficult to maintain by most patients. However, the recent focus on the intestinal microbiota and its important role in the host's metabolism provides a new key for improving metabolic health. Modulating the composition of the gut microbiota was proposed as a method to manage these metabolic diseases and most frequently this is undertaken by using probiotics, prebiotics or synbiotics. Furthermore, the action of metformin, the most commonly prescribed drug for treating T2DM, is mediated in part by the gut microbiota, although this interplay may also be responsible for the frequent gastrointestinal adverse effects of metformin. Thus, adding a gut microbiota modulator (GMM), such as probiotics or prebiotics, to metformin therapy could amplify its anti-diabetic effects, while decreasing its adverse reactions. This review summarizes the various therapies that are used to shift the composition of the microbiome and their efficacy in alleviating metabolic parameters, it assesses the interaction between metformin and the gut microbiota, and it evaluates the existing clinical and preclinical studies that analyze the potential synergy of a combined metformin-GMM therapy.
C1 [Seicaru, Elena Maria; Ilie, Ioana Rada Popa; Ghervan, Cristina] Iuliu Haieganu Univ Med & Pharm, Dept Endocrinol, Cluj Napoca, Romania.
   [Catinean, Adrian] Iuliu Haieganu Univ Med & Pharm, Dept Internal Med, Cluj Napoca, Romania.
   [Craciun, Alexandra Marioara] Iuliu Haieganu Univ Med & Pharm, Dept Mol Sci, Cluj Napoca, Romania.
RP Ilie, IRP (通讯作者)，Iuliu Haieganu Univ Med & Pharm, Dept Endocrinol, Cluj Napoca, Romania.
EM ioanamanaila@yahoo.com
RI Popa-Ilie, Ioana Rada/C-5122-2011; Craciun, Alexandra M/G-5762-2011
OI Popa-Ilie, Ioana Rada/0000-0002-5281-5004; Craciun, Alexandra
   M/0000-0003-3703-1874
FU "Iuliu Hatieganu" University of Medicine and Pharmacy
   [881/47/12.01.2022]
FX The current paper was supported by a grant from the,Iuliu
   Ha.ieganu"University of Medicine and Pharmacy (contract no
   881/47/12.01.2022).
CR Aguirre V, 2002, J BIOL CHEM, V277, P1531, DOI 10.1074/jbc.M101521200
   Akbari V, 2016, NUTR REV, V74, P774, DOI 10.1093/nutrit/nuw039
   Alang N, 2015, OPEN FORUM INFECT DI, V2, DOI 10.1093/ofid/ofv004
   Amyot J, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0036200
   An HY, 2016, J ENDOCRINOL, V228, pR97, DOI 10.1530/JOE-15-0447
   Anderson RC, 2010, BMC MICROBIOL, V10, DOI 10.1186/1471-2180-10-316
   Ansari A, 2020, AM J CHINESE MED, V48, P1409, DOI 10.1142/S0192415X2050069X
   Ardeshirlarijani E, 2019, DARU, V27, P827, DOI 10.1007/s40199-019-00302-2
   Atassi F, 2010, FEMS MICROBIOL LETT, V304, P29, DOI 10.1111/j.1574-6968.2009.01887.x
   Bahne E, 2016, DIABETES OBES METAB, V18, P955, DOI 10.1111/dom.12697
   Bailey CJ, 2008, DIABETOLOGIA, V51, P1552, DOI 10.1007/s00125-008-1053-5
   Barazzoni R, 2018, EAT WEIGHT DISORD-ST, V23, P149, DOI 10.1007/s40519-018-0481-6
   Bauer PV, 2018, CELL METAB, V27, P101, DOI 10.1016/j.cmet.2017.09.019
   BONORA E, 1984, CURR MED RES OPIN, V9, P47, DOI 10.1185/03007998409109558
   Borgeraas H, 2018, OBES REV, V19, P219, DOI 10.1111/obr.12626
   Burton Jeffrey H, 2015, J Diabetes Sci Technol, V9, P808, DOI 10.1177/1932296815577425
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   Carter D, 2002, DIABETES OBES METAB, V4, P424, DOI 10.1046/j.1463-1326.2002.00223.x
   Chambers ES, 2015, GUT, V64, P1744, DOI 10.1136/gutjnl-2014-307913
   Chen LH, 2012, AM J PHYSIOL-ENDOC M, V302, pE68, DOI 10.1152/ajpendo.00323.2011
   Dao MC, 2016, GUT, V65, P426, DOI 10.1136/gutjnl-2014-308778
   de Groot P, 2020, GUT, V69, P502, DOI 10.1136/gutjnl-2019-318320
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   de Luca C, 2008, FEBS LETT, V582, P97, DOI 10.1016/j.febslet.2007.11.057
   De Vadder F, 2014, CELL, V156, P84, DOI 10.1016/j.cell.2013.12.016
   Deehan EC, 2021, TRIALS, V22, DOI 10.1186/s13063-021-05060-8
   Diaz-Perdigones CM, 2022, BIOMED PHARMACOTHER, V145, DOI 10.1016/j.biopha.2021.112448
   Duran-Sandoval D, 2005, J BIOL CHEM, V280, P29971, DOI 10.1074/jbc.M501931200
   Ewaschuk JB, 2008, AM J PHYSIOL-GASTR L, V295, pG1025, DOI 10.1152/ajpgi.90227.2008
   Food and Agricultural Organization of the United Nations and World Health Organization, 2001, HLTH NUTR PROP PROB
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Gibson GR, 2017, NAT REV GASTRO HEPAT, V14, P491, DOI 10.1038/nrgastro.2017.75
   Hadi A, 2020, CRIT REV FOOD SCI, V60, P584, DOI 10.1080/10408398.2018.1545218
   Hampe CS, 2017, ENDOCRINE, V58, P207, DOI 10.1007/s12020-017-1433-z
   Han K, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0182467
   Hashimoto Y, 2020, J CLIN BIOCHEM NUTR, V67, P223, DOI 10.3164/jcbn.20-100
   He J, 2017, MEDICINE, V96, DOI [10.1097/MD.0000000000009166, 10.1097/md.0000000000009166]
   Hu YM, 2017, MED CLIN-BARCELONA, V148, P362, DOI [10.1016/j.medcle.2017.03.003, 10.1016/j.medcli.2016.11.036]
   Inagaki T, 2006, P NATL ACAD SCI USA, V103, P3920, DOI 10.1073/pnas.0509592103
   Jafarabadi MA, 2021, CURR DIABETES REV, V17, P356, DOI 10.2174/1573399816666200812151029
   Jensen JB, 2016, DIABETES, V65, P1724, DOI 10.2337/db16-0032
   Karczewski J, 2010, AM J PHYSIOL-GASTR L, V298, pG851, DOI 10.1152/ajpgi.00327.2009
   Kasinska MA, 2015, POL ARCH MED WEWN, V125, P803, DOI 10.20452/pamw.3156
   Kawamata Y, 2003, J BIOL CHEM, V278, P9435, DOI 10.1074/jbc.M209706200
   Ke HR, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.726707
   Kimura I, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms2852
   Kocsis T, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-68440-1
   Koh A, 2016, CELL, V165, P1332, DOI 10.1016/j.cell.2016.05.041
   Kootte RS, 2017, CELL METAB, V26, P611, DOI 10.1016/j.cmet.2017.09.008
   Koutnikova H, 2019, BMJ OPEN, V9, DOI 10.1136/bmjopen-2017-017995
   KREYMANN B, 1987, LANCET, V2, P1300
   le Roux CW, 2006, ENDOCRINOLOGY, V147, P3, DOI 10.1210/en.2005-0972
   Lee SE, 2019, DIABETES METAB J, V43, P422, DOI 10.4093/dmj.2018.0090
   Ley RE, 2006, NATURE, V444, P1022, DOI 10.1038/4441022a
   Li CF, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000004088
   Li JH, 2014, NAT BIOTECHNOL, V32, P834, DOI 10.1038/nbt.2942
   Li QZ, 2020, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00939
   Liang TT, 2021, CRIT REV FOOD SCI, V61, P1670, DOI [10.1080/10408398.2020.1764488, 10.1145/3403676.3403677]
   Lopez-Moreno A, 2020, NUTRIENTS, V12, DOI 10.3390/nu12071921
   Makishima M, 1999, SCIENCE, V284, P1362, DOI 10.1126/science.284.5418.1362
   McLaughlin T, 2011, J CLIN ENDOCR METAB, V96, pE1756, DOI 10.1210/jc.2011-0615
   Mohammadi H, 2019, COMPLEMENT THER MED, V44, P269, DOI 10.1016/j.ctim.2019.05.008
   Palacios T, 2020, NUTRIENTS, V12, DOI 10.3390/nu12072041
   Pandey KB, 2009, OXID MED CELL LONGEV, V2, P270, DOI 10.4161/oxim.2.5.9498
   Park J, 2015, MUCOSAL IMMUNOL, V8, P80, DOI 10.1038/mi.2014.44
   Park S, 2015, NUTR RES, V35, P566, DOI 10.1016/j.nutres.2015.05.008
   Parnell JA, 2012, BRIT J NUTR, V107, P601, DOI 10.1017/S0007114511003163
   Perna S, 2021, NUTRIENTS, V13, DOI 10.3390/nu13020666
   Reimer RA, 2014, J ENDOCRINOL, V220, P361, DOI 10.1530/JOE-13-0484
   Remely M, 2016, ENDOCR METAB IMMUNE, V16, P99, DOI 10.2174/1871530316666160831093813
   Ridaura VK, 2013, SCIENCE, V341, P1079, DOI 10.1126/science.1241214
   Robeson MS, 2022, FRONT MICROBIOL, V13, DOI 10.3389/fmicb.2022.834776
   Ruan YT, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0132121
   Samah S, 2016, DIABETES RES CLIN PR, V118, P172, DOI 10.1016/j.diabres.2016.06.014
   Samuel VT, 2012, CELL, V148, P852, DOI 10.1016/j.cell.2012.02.017
   Scarpello JHB, 1998, DIABETIC MED, V15, P651, DOI 10.1002/(SICI)1096-9136(199808)15:8<651::AID-DIA628>3.0.CO;2-A
   Shin NR, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.02271
   Shin NR, 2020, AM J PHYSIOL-ENDOC M, V318, pE52, DOI 10.1152/ajpendo.00221.2019
   Stein CJ, 2004, J CLIN ENDOCR METAB, V89, P2522, DOI 10.1210/jc.2004-0288
   Stenman LK, 2015, DIABETOL METAB SYNDR, V7, DOI 10.1186/s13098-015-0075-7
   Stepensky D, 2001, J CONTROL RELEASE, V71, P107, DOI 10.1016/S0168-3659(00)00374-6
   Sun J, 2016, BRIT J NUTR, V115, P1167, DOI 10.1017/S0007114516000076
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Suzumura EA, 2019, NUTR REV, V77, P430, DOI 10.1093/nutrit/nuz001
   Sze MA, 2016, MBIO, V7, DOI 10.1128/mBio.01018-16
   Tabrizi R, 2018, PROBIOTICS ANTIMICRO, V10, P329, DOI 10.1007/s12602-017-9299-1
   Tao YW, 2020, J TRANSL MED, V18, DOI 10.1186/s12967-020-02213-2
   Tedelind S, 2007, WORLD J GASTROENTERO, V13, P2826, DOI 10.3748/wjg.v13.i20.2826
   Thomas C, 2009, CELL METAB, V10, P167, DOI 10.1016/j.cmet.2009.08.001
   Tian PJ, 2016, FOOD FUNCT, V7, P3789, DOI [10.1039/c6fo00831c, 10.1039/C6FO00831C]
   Toejing P, 2020, NUTRIENTS, V12, DOI 10.3390/nu12103015
   Torres S, 2019, EUR J NUTR, V58, P27, DOI 10.1007/s00394-018-1790-2
   Trabelsi MS, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms8629
   Turton MD, 1996, NATURE, V379, P69, DOI 10.1038/379069a0
   Vrieze A, 2012, GASTROENTEROLOGY, V143, P913, DOI 10.1053/j.gastro.2012.06.031
   Waldecker M, 2008, J NUTR BIOCHEM, V19, P587, DOI 10.1016/j.jnutbio.2007.08.002
   Wang JH, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00620
   Wang JH, 2017, GENES-BASEL, V8, DOI 10.3390/genes8100239
   Williams KJ, 2016, ATHEROSCLEROSIS, V247, P225, DOI 10.1016/j.atherosclerosis.2016.02.004
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Wu HJ, 2012, GUT MICROBES, V3, P4, DOI 10.4161/gmic.19320
   Yao KC, 2017, MED SCI MONITOR, V23, DOI 10.12659/MSM.902600
   Zhang LJ, 2020, AGING-US, V12, P17480, DOI 10.18632/aging.103756
   Zhang QQ, 2016, INT J FOOD SCI NUTR, V67, P571, DOI 10.1080/09637486.2016.1181156
   Zhang QQ, 2016, MEDICINA-LITHUANIA, V52, P28, DOI 10.1016/j.medici.2015.11.008
   Zhang X, 2015, SCI REP-UK, V5, DOI 10.1038/srep14405
   Zheng JL, 2018, J AGR FOOD CHEM, V66, P5821, DOI [10.1021/acsjafc.8b00829, 10.1021/acs.jafc.8b00829]
   Zhou ZY, 2016, ACTA PHARMACOL SIN, V37, P1063, DOI 10.1038/aps.2016.21
NR 108
TC 1
Z9 1
U1 4
U2 6
PU MEDICAL UNIV PRESS
PI CLUJ-NAPOCA
PA 3RD MEDICAL CLINIC, STR CROITORILOR NO 19-21, CLUJ-NAPOCA, 400162,
   ROMANIA
SN 1841-8724
EI 1842-1121
J9 J GASTROINTEST LIVER
JI J. Gastrointest. Liver Dis.
PD SEP
PY 2022
VL 31
IS 3
BP 344
EP 354
DI 10.15403/jgld-4248
PG 11
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 6T2ZU
UT WOS:000893549200013
PM 36112705
OA gold
DA 2023-06-08
ER

PT J
AU Yang, JY
   Liu, MJ
   Lv, L
   Guo, JR
   He, KY
   Zhang, H
   Wang, KK
   Cui, CY
   Yan, BZ
   Du, DD
   Wang, JH
   Ding, Q
   Liu, GL
   Xu, ZX
   Jian, YP
AF Yang, Jing-Yu
   Liu, Meng-Jie
   Lv, Lin
   Guo, Jin-Rong
   He, Kai-Yue
   Zhang, Hong
   Wang, Ke-Ke
   Cui, Cui-Yun
   Yan, Bei-Zhan
   Du, Dan-Dan
   Wang, Jin-Hua
   Ding, Qiang
   Liu, Guo-Long
   Xu, Zhi-Xiang
   Jian, Yong-Ping
TI Metformin alleviates irradiation-induced intestinal injury by activation
   of FXR in intestinal epithelia
SO FRONTIERS IN MICROBIOLOGY
LA English
DT Article
DE irradiation-induced intestinal injury; microbiota; Lactobacillus;
   metformin; intestinal barrier; farnesoid X receptor (FXR)
ID AGONIST OBETICHOLIC ACID; X RECEPTOR AGONIST; GUT MICROBIOME; ALTERS;
   RADIOTHERAPY; PROTECTS; ADENOMA; CANCER
AB Abdominal irradiation (IR) destroys the intestinal mucosal barrier, leading to severe intestinal infection. There is an urgent need to find safe and effective treatments to reduce IR-induced intestinal injury. In this study, we reported that metformin protected mice from abdominal IR-induced intestinal injury by improving the composition and diversity of intestinal flora. The elimination of intestinal microbiota (Abx) abrogated the protective effects of metformin on irradiated mice. We further characterized that treatment of metformin increased the murine intestinal abundance of Lactobacillus, which mediated the radioprotective effect. The administration of Lactobacillus or fecal microbiota transplantation (FMT) into Abx mice considerably lessened IR-induced intestinal damage and restored the radioprotective function of metformin in Abx mice. In addition, applying the murine intestinal organoid model, we demonstrated that IR inhibited the formation of intestinal organoids, and metformin alone bore no protective effect on organoids after IR. However, a combination of metformin and Lactobacillus or Lactobacillus alone displayed a strong radioprotection on the organoid formation. We demonstrated that metformin/Lactobacillus activated the farnesoid X receptor (FXR) signaling in intestinal epithelial cells and hence upregulated tight junction proteins and mucins in intestinal epithelia, increased the number of goblet cells, and augmented the mucus layer thickness to maintain the integrity of intestinal epithelial barrier, which eventually contributed to reduced radiation intestinal injury. In addition, we found that Lactobacillus abundance was significantly increased in the intestine of patients receiving metformin while undergoing abdominal radiotherapy and the abundance was negatively correlated with the diarrhea duration of patients. In conclusion, our results demonstrate that metformin possesses a protective effect on IR-induced intestinal injury by upregulating the abundance of Lactobacillus in the intestine.
C1 [Yang, Jing-Yu; Liu, Meng-Jie; Guo, Jin-Rong; He, Kai-Yue; Zhang, Hong; Xu, Zhi-Xiang; Jian, Yong-Ping] Henan Univ, Sch Life Sci, Kaifeng, Peoples R China.
   [Lv, Lin; Liu, Guo-Long] South China Univ Technol, Guangzhou Peoples Hosp 1, Sch Med, Dept Med Oncol, Guangzhou, Peoples R China.
   [Wang, Ke-Ke; Wang, Jin-Hua] Nanjing Med Univ, Jiangsu Canc Hosp, Jiangsu Inst Canc Res, Affiliated Canc Hosp, Nanjing, Peoples R China.
   [Cui, Cui-Yun; Yan, Bei-Zhan] Zhengzhou Univ, Henan Prov Peoples Hosp, Dept Blood Transfus, Peoples Hosp, Zhengzhou, Peoples R China.
   [Du, Dan-Dan] Ningjin Cty Peoples Hosp, Dept Internal Med, Dezhou, Peoples R China.
   [Ding, Qiang; Xu, Zhi-Xiang] Univ Alabama Birmingham, Dept Med, Birmingham, AL 35294 USA.
C3 Henan University; South China University of Technology; Nanjing Medical
   University; Zhengzhou University; University of Alabama System;
   University of Alabama Birmingham
RP Xu, ZX; Jian, YP (通讯作者)，Henan Univ, Sch Life Sci, Kaifeng, Peoples R China.; Liu, GL (通讯作者)，South China Univ Technol, Guangzhou Peoples Hosp 1, Sch Med, Dept Med Oncol, Guangzhou, Peoples R China.; Xu, ZX (通讯作者)，Univ Alabama Birmingham, Dept Med, Birmingham, AL 35294 USA.
EM eyglliu@scut.edu.cn; zhixiangxu08@gmail.com; yongpingjian123@163.com
RI yang, jingyu/GXF-5534-2022; Liu, Mengjie/AAO-5256-2020
OI yang, jingyu/0000-0002-9860-7067; 
FU National Natural Science Foundation of China;  [82020108024]; 
   [32161143021];  [81772924]
FX Funding This study was supported by the National Natural Science
   Foundation of China (Nos. 82020108024, 32161143021, and 81772924).
CR Andreyev J, 2005, GUT, V54, P1051, DOI 10.1136/gut.2004.062596
   Bauer PV, 2018, CELL METAB, V27, P101, DOI 10.1016/j.cmet.2017.09.019
   Castellanos JG, 2018, IMMUNITY, V49, P1077, DOI 10.1016/j.immuni.2018.10.014
   Chaves-Perez A, 2019, SCIENCE, V364, P849, DOI 10.1126/science.aaq1165
   Chen L, 2020, BRIT J PHARMACOL, V177, P3991, DOI 10.1111/bph.15149
   CHIU CJ, 1970, ARCH SURG-CHICAGO, V101, P478
   Cui M, 2017, EMBO MOL MED, V9, P448, DOI 10.15252/emmm.201606932
   De Ruysscher D, 2019, NAT REV DIS PRIMERS, V5, DOI 10.1038/s41572-019-0064-5
   Ding SY, 2020, GASTROENTEROLOGY, V159, P214, DOI 10.1053/j.gastro.2020.03.053
   Fransson P, 2007, ACTA ONCOL, V46, P517, DOI 10.1080/02841860601113596
   Fu T, 2019, CELL, V176, P1098, DOI 10.1016/j.cell.2019.01.036
   Gadaleta RM, 2011, GUT, V60, P463, DOI 10.1136/gut.2010.212159
   Garcia-Calzon S, 2020, SCI TRANSL MED, V12, DOI 10.1126/scitranslmed.aaz1803
   Gerassy-Vainberg S, 2018, GUT, V67, P97, DOI 10.1136/gutjnl-2017-313789
   Gulati S, 2020, CANCER-AM CANCER SOC, V126, P354, DOI 10.1002/cncr.32539
   Guo H, 2020, SCIENCE, V370, P549, DOI 10.1126/science.aay9097
   Hanninen A, 2018, GUT, V67, P1445, DOI 10.1136/gutjnl-2017-314508
   Hauer-Jensen M, 2014, NAT REV GASTRO HEPAT, V11, P470, DOI 10.1038/nrgastro.2014.46
   Higurashi T, 2016, LANCET ONCOL, V17, P475, DOI 10.1016/S1470-2045(15)00565-3
   Hunter RW, 2018, NAT MED, V24, P1395, DOI 10.1038/s41591-018-0159-7
   Jain U, 2021, SCIENCE, V371, P1154, DOI 10.1126/science.abd0919
   Jian YP, 2022, J CELL PHYSIOL, V237, P1845, DOI 10.1002/jcp.30651
   Jian YP, 2021, FRONT CELL INFECT MI, V11, DOI 10.3389/fcimb.2021.586392
   Jiang CT, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms10166
   Koh A, 2020, CELL METAB, V32, P643, DOI 10.1016/j.cmet.2020.07.012
   Liu YH, 2020, HEPATOLOGY, V71, P2050, DOI 10.1002/hep.30975
   McKenzie C, 2017, IMMUNOL REV, V278, P277, DOI 10.1111/imr.12556
   Miller KD, 2019, CA-CANCER J CLIN, V69, P363, DOI 10.3322/caac.21565
   Modica S, 2012, GASTROENTEROLOGY, V142, P355, DOI 10.1053/j.gastro.2011.10.028
   Mori K, 2011, INTENS CARE MED, V37, P1849, DOI 10.1007/s00134-011-2326-x
   Mudaliar S, 2013, GASTROENTEROLOGY, V145, P574, DOI 10.1053/j.gastro.2013.05.042
   Ottewell PD, 2003, GASTROENTEROLOGY, V124, P1348, DOI 10.1016/S0016-5085(03)00288-9
   Panigrahi P, 2017, NATURE, V548, P407, DOI 10.1038/nature23480
   Park M, 2021, CELL BIOL INT, V45, P1523, DOI 10.1002/cbin.11591
   Sato Toshiro, 2013, Methods Mol Biol, V945, P319, DOI 10.1007/978-1-62703-125-7_19
   Sato T, 2011, GASTROENTEROLOGY, V141, P1762, DOI 10.1053/j.gastro.2011.07.050
   Scott NA, 2018, SCI TRANSL MED, V10, DOI 10.1126/scitranslmed.aao4755
   Seok S, 2014, NATURE, V516, P108, DOI 10.1038/nature13949
   van den Berg FF, 2021, GUT, V70, P915, DOI 10.1136/gutjnl-2019-320430
   Vanwijngaerden YM, 2011, HEPATOLOGY, V54, P1741, DOI 10.1002/hep.24582
   Verbeke L, 2015, AM J PATHOL, V185, P409, DOI 10.1016/j.ajpath.2014.10.009
   Verbeke L, 2014, HEPATOLOGY, V59, P2286, DOI 10.1002/hep.26939
   Wang J, 2017, RADIAT RES, V188, P105, DOI 10.1667/RR14708.1
   Wang YD, 2008, HEPATOLOGY, V48, P1632, DOI 10.1002/hep.22519
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Xu GS, 2015, FREE RADICAL BIO MED, V87, P15, DOI 10.1016/j.freeradbiomed.2015.05.045
   Yang DP, 2019, IMMUNITY, V50, P692, DOI 10.1016/j.immuni.2019.02.001
   Yang J, 2022, GASTROENTEROLOGY, V162, P135, DOI 10.1053/j.gastro.2021.08.041
   Zarrinpar A, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-018-05336-9
NR 49
TC 1
Z9 1
U1 7
U2 10
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1664-302X
J9 FRONT MICROBIOL
JI Front. Microbiol.
PD OCT 13
PY 2022
VL 13
AR 932294
DI 10.3389/fmicb.2022.932294
PG 18
WC Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology
GA 5T4NN
UT WOS:000875845500001
PM 36312920
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Ma, W
   Chen, J
   Meng, YH
   Yang, JC
   Cui, QH
   Zhou, Y
AF Ma, Wei
   Chen, Ji
   Meng, Yuhong
   Yang, Jichun
   Cui, Qinghua
   Zhou, Yuan
TI Metformin Alters Gut Microbiota of Healthy Mice: Implication for Its
   Potential Role in Gut Microbiota Homeostasis
SO FRONTIERS IN MICROBIOLOGY
LA English
DT Article
DE metformin; gut microbiome; diabetes; 16S rRNA sequencing; MicroPattern
ID INTESTINAL MICROBIOTA; CANCER; GLUCOSE; METABOLISM; THERAPY;
   PHOSPHATIDYLCHOLINE; TUMORIGENESIS; INFLAMMATION; INDIVIDUALS;
   ASSOCIATION
AB In recent years, the first-line anti-diabetic drug metformin has been shown to be also useful for the treatment of other diseases like cancer. To date, few reports were about the impact of metformin on gut microbiota. To fully understand the mechanism of action of metformin in treating diseases other than diabetes, it is especially important to investigate the impact of long-term metformin treatment on the gut microbiome in non-diabetic status. In this study, we treated healthy mice with metformin for 30 days, and observed 46 significantly changed gut microbes by using the 16S rRNA-based microbiome profiling technique. We found that microbes from the Verrucomicrobiaceae and Prevotellaceae classes were enriched, while those from Lachnospiraceae and Rhodobacteraceae were depleted. We further compared the altered microbiome profile with the profiles under various disease conditions using our recently developed comparative microbiome tool known as MicroPattern. Interestingly, the treatment of diabetes patients with metformin positively correlates with colon cancer and type 1 diabetes, indicating a confounding effect on the gut microbiome in patients with diabetes. However, the treatment of healthy mice with metformin exhibits a negative correlation with multiple inflammatory diseases, indicating a protective anti-inflammatory role of metformin in non-diabetes status. This result underscores the potential effect of metformin on gut microbiome homeostasis, which may contribute to the treatment of non-diabetic diseases.
C1 [Ma, Wei; Cui, Qinghua; Zhou, Yuan] Peking Univ, Sch Basic Med Sci, Dept Biomed Informat, Beijing, Peoples R China.
   [Ma, Wei; Chen, Ji; Meng, Yuhong; Yang, Jichun; Cui, Qinghua; Zhou, Yuan] Peking Univ, Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing, Peoples R China.
   [Ma, Wei] PLA Navy Gen Hosp, Cent Lab, Beijing, Peoples R China.
   [Chen, Ji; Meng, Yuhong; Yang, Jichun; Cui, Qinghua] Peking Univ, Sch Basic Med Sci, Dept Physiol & Pathophysiol, Beijing, Peoples R China.
C3 Peking University; Peking University; Sixth Medical Center of Chinese
   PLA General Hospital; Peking University
RP Cui, QH; Zhou, Y (通讯作者)，Peking Univ, Sch Basic Med Sci, Dept Biomed Informat, Beijing, Peoples R China.; Cui, QH; Zhou, Y (通讯作者)，Peking Univ, Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing, Peoples R China.; Cui, QH (通讯作者)，Peking Univ, Sch Basic Med Sci, Dept Physiol & Pathophysiol, Beijing, Peoples R China.
EM cuiqinghua@hsc.pku.edu.cn; soontide6825@163.com
RI Ma, Wei/J-6046-2019
OI Ma, Wei/0000-0003-1044-5612
FU National High Technology Research and Development Program of China
   [2014AA021102]; National Natural Science Foundation of China [81422006,
   81670462]; China Postdoctoral Science Foundation [2016M591024]
FX This study was supported by the National High Technology Research and
   Development Program of China (Grant No. 2014AA021102 to QC), the
   National Natural Science Foundation of China (Grant Nos. 81422006 and
   81670462 to QC), and China Postdoctoral Science Foundation (2016M591024
   to YZ).
CR Allin KH, 2018, DIABETOLOGIA, V61, P810, DOI 10.1007/s00125-018-4550-1
   Bailey CJ, 1996, NEW ENGL J MED, V334, P574, DOI 10.1056/NEJM199602293340906
   Banati M, 2013, EUR J NEUROL, V20, P1492, DOI 10.1111/ene.12072
   Bao B, 2012, CANCER PREV RES, V5, P355, DOI 10.1158/1940-6207.CAPR-11-0299
   Berer K, 2011, NATURE, V479, P538, DOI 10.1038/nature10554
   Bolte ER, 1998, MED HYPOTHESES, V51, P133, DOI 10.1016/S0306-9877(98)90107-4
   BONORA E, 1984, CURR MED RES OPIN, V9, P47, DOI 10.1185/03007998409109558
   Buse JB, 2016, DIABETES CARE, V39, P198, DOI 10.2337/dc15-0488
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Evans JMM, 2005, BMJ-BRIT MED J, V330, P1304, DOI 10.1136/bmj.38415.708634.F7
   Ezendam J, 2008, CLIN EXP IMMUNOL, V154, P424, DOI 10.1111/j.1365-2249.2008.03788.x
   Finegold SM, 2010, ANAEROBE, V16, P444, DOI 10.1016/j.anaerobe.2010.06.008
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Franciosi M, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0071583
   Furet JP, 2010, DIABETES, V59, P3049, DOI 10.2337/db10-0253
   Garber AJ, 2013, ENDOCR PRACT, V19, P536, DOI 10.4158/EP13176.CS
   Gundelach Theresa, 2016, Med Monatsschr Pharm, V39, P75
   Heckman-Stoddard BM, 2016, SEMIN ONCOL, V43, P123, DOI 10.1053/j.seminoncol.2015.09.009
   Hundal RS, 2000, DIABETES, V49, P2063, DOI 10.2337/diabetes.49.12.2063
   Igel LI, 2016, CURR ATHEROSCLER REP, V18, DOI 10.1007/s11883-016-0568-3
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kedia R, 2016, PATIENT PREFER ADHER, V10, P1999, DOI 10.2147/PPA.S85748
   Kemp PF, 2004, FEMS MICROBIOL ECOL, V47, P161, DOI 10.1016/S0168-6496(03)00257-5
   Koeth RA, 2013, NAT MED, V19, P576, DOI 10.1038/nm.3145
   Koh SJ, 2014, J GASTROEN HEPATOL, V29, P502, DOI 10.1111/jgh.12435
   Kostic AD, 2013, CELL HOST MICROBE, V14, P207, DOI 10.1016/j.chom.2013.07.007
   Langille MGI, 2013, NAT BIOTECHNOL, V31, P814, DOI 10.1038/nbt.2676
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Lee H, 2018, GERONTOLOGIST, V58, P159, DOI 10.1093/geront/gnx050
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Lee YK, 2011, P NATL ACAD SCI USA, V108, P4615, DOI 10.1073/pnas.1000082107
   Ley RE, 2010, CURR OPIN GASTROEN, V26, P5, DOI 10.1097/MOG.0b013e328333d751
   Liu G., 2018, FOOD RES, V62, DOI [10.1002/mnfr.201700954, DOI 10.1002/MNFR.201700954]
   Lukens JR, 2014, NATURE, V516, P246, DOI 10.1038/nature13788
   Ma W, 2017, SCI REP-UK, V7, DOI 10.1038/srep40200
   May A, 2016, BIOINFORMATICS, V32, P1678, DOI 10.1093/bioinformatics/btv526
   Novelle MG, 2016, CSH PERSPECT MED, V6, DOI 10.1101/cshperspect.a025932
   O'Hara AM, 2006, EMBO REP, V7, P688, DOI 10.1038/sj.embor.7400731
   Ochoa-Reparaz J, 2011, ANN NEUROL, V69, P240, DOI 10.1002/ana.22344
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Restrepo BI, 2016, TUBERCULOSIS, V101, pS69, DOI 10.1016/j.tube.2016.09.008
   Scher JU, 2013, ELIFE, V2, DOI 10.7554/eLife.01202
   Schloss PD, 2009, APPL ENVIRON MICROB, V75, P7537, DOI 10.1128/AEM.01541-09
   Schwabe RF, 2013, NAT REV CANCER, V13, P800, DOI 10.1038/nrc3610
   Shafiee MN, 2014, GYNECOL ONCOL, V132, P248, DOI 10.1016/j.ygyno.2013.10.028
   Shank JJ, 2012, GYNECOL ONCOL, V127, P390, DOI 10.1016/j.ygyno.2012.07.115
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Sosnicki S, 2016, PHARMACOL REP, V68, P918, DOI 10.1016/j.pharep.2016.04.021
   Stepensky D, 2002, DRUG METAB DISPOS, V30, P861, DOI 10.1124/dmd.30.8.861
   Tang WHW, 2013, NEW ENGL J MED, V368, P1575, DOI 10.1056/NEJMoa1109400
   Varrin-Doyer M, 2012, ANN NEUROL, V72, P53, DOI 10.1002/ana.23651
   Wang Y, 2014, BRAIN BEHAV IMMUN, V38, P1, DOI 10.1016/j.bbi.2013.12.015
   Wang ZN, 2011, NATURE, V472, P57, DOI 10.1038/nature09922
   Wen L, 2008, NATURE, V455, P1109, DOI 10.1038/nature07336
   Witters LA, 2001, J CLIN INVEST, V108, P1105, DOI 10.1172/JCI14178
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Wu L, 2015, SCI REP-UK, V5, DOI 10.1038/srep10147
   Wu SG, 2009, NAT MED, V15, P1016, DOI 10.1038/nm.2015
   Zhang HH, 2016, CANCER CHEMOTH PHARM, V78, P13, DOI 10.1007/s00280-016-3037-3
   Zhang HS, 2009, P NATL ACAD SCI USA, V106, P2365, DOI 10.1073/pnas.0812600106
   Zhang XQ, 2015, SCI REP-UK, V5, DOI 10.1038/srep10737
   Zhang ZJ, 2014, DIABETES OBES METAB, V16, P707, DOI 10.1111/dom.12267
NR 62
TC 41
Z9 42
U1 3
U2 30
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1664-302X
J9 FRONT MICROBIOL
JI Front. Microbiol.
PD JUN 22
PY 2018
VL 9
AR 1336
DI 10.3389/fmicb.2018.01336
PG 8
WC Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology
GA GK4BV
UT WOS:000436100000001
PM 29988362
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Rodriguez, J
   Hiel, S
   Delzenne, NM
AF Rodriguez, Julie
   Hiel, Sophie
   Delzenne, Nathalie M.
TI Metformin: old friend, new ways of action-implication of the gut
   microbiome?
SO CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
LA English
DT Review
DE diabetes; gut microbiota; intestinal function; metformin
ID GLUCAGON-LIKE PEPTIDE-1; CHAIN FATTY-ACIDS; GLUCOSE; HYPERGLYCEMIA;
   INDIVIDUALS; ENDOTOXEMIA; SECRETION; ALTERS; IMPACT
AB Purpose of reviewGut dysbiosis was recently associated with the occurrence of type 2 diabetes (T2D). In addition to this finding, an increasing number of studies performed upon the last 5 years have also shown that metformin treatment leads to changes in gut bacterial composition in diabetic patients. This review focuses on the articles describing the effects of metformin on gut homeostasis (including the gut microbiota) and proposes potential mechanisms involved in those effects.Recent findingsSeveral human and animal studies emphasized that metformin alters the gut microbiota composition by enhancing the growth of some bacteria, such as Akkermansia muciniphila, Escherichia spp. or Lactobacillus and by decreasing the levels of some other ones like Intestinibacter. In-vitro studies also demonstrated a direct action of metformin on the growth of A. muciniphila and Bifidobacterium adolescentis. Moreover, in the intestines, metformin does not only improve the glucose uptake, but it also promotes the short-chain fatty acid (SCFA) production, protects the intestinal barrier and regulates the secretion of gut peptidesSummaryIt is now clear that gut microbiota participates to the glucose-lowering effects of metformin in the context of diabetes. Further work is now needed to determine the exact mechanisms of action of the drug and to understand by which processes metformin is able to enhance the growth of some bacteria exhibiting beneficial effects for the host.
C1 [Rodriguez, Julie; Hiel, Sophie; Delzenne, Nathalie M.] Catholic Univ Louvain, Louvain Drug Res Inst, Metab & Nutr Res Grp, Ave E Mounier 73 Bte B1-73-11, B-1200 Brussels, Belgium.
C3 Universite Catholique Louvain
RP Delzenne, NM (通讯作者)，Catholic Univ Louvain, Louvain Drug Res Inst, Metab & Nutr Res Grp, Ave E Mounier 73 Bte B1-73-11, B-1200 Brussels, Belgium.
EM nathalie.delzenne@uclouvain.be
RI Delzenne, Nathalie/AAC-4628-2019; Rodriguez, Julie/AAM-7813-2020
OI Delzenne, Nathalie/0000-0003-2115-6082; Rodriguez,
   Julie/0000-0002-8271-3893
FU FRS-FNRS; Wallonia (ADIPOSTOP project) [7366]; Wallonia (FOOD4GUT
   project) [1318148]; Wallonia (FiberTAG project from a Joint Programming
   Initiative) [1610365]; European Union [613979]
FX N.M.D. is a recipient of grants from FRS-FNRS, from Wallonia (ADIPOSTOP
   project, convention 7366; FOOD4GUT project, convention 1318148; FiberTAG
   project from a Joint Programming Initiative, convention 1610365) and
   from the European Union's Seventh Framework Program (MYNEWGUT project,
   agreement no. 613979).
CR An HY, 2016, J ENDOCRINOL, V228, pR97, DOI 10.1530/JOE-15-0447
   Bahne E, 2016, DIABETES OBES METAB, V18, P955, DOI 10.1111/dom.12697
   Bauer PV, 2018, CELL METAB, V27, P101, DOI 10.1016/j.cmet.2017.09.019
   Bronden A, 2017, J CLIN ENDOCR METAB, V102, P4153, DOI 10.1210/jc.2017-01091
   Brunkwall L, 2017, DIABETOLOGIA, V60, P943, DOI 10.1007/s00125-017-4278-3
   Cabreiro F, 2013, CELL, V153, P228, DOI 10.1016/j.cell.2013.02.035
   Canfora EE, 2015, NAT REV ENDOCRINOL, V11, P577, DOI 10.1038/nrendo.2015.128
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Cani PD, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.01765
   Cani PD, 2009, AM J CLIN NUTR, V90, P1236, DOI 10.3945/ajcn.2009.28095
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   De Vadder F, 2014, CELL, V156, P84, DOI 10.1016/j.cell.2013.12.016
   DeFronzo RA, 2016, DIABETOLOGIA, V59, P1645, DOI 10.1007/s00125-016-3992-6
   Delzenne NM, 2015, DIABETOLOGIA, V58, P2206, DOI 10.1007/s00125-015-3712-7
   Duca FA, 2015, NAT MED, V21, P506, DOI 10.1038/nm.3787
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Huang F, 2017, IEEE T CIRCUITS SYST, P1, DOI DOI 10.1109/ACCESS.2017.2687882
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Koffert JP, 2017, DIABETES RES CLIN PR, V131, P208, DOI 10.1016/j.diabres.2017.07.015
   Lee H, 2018, GERONTOLOGIST, V58, P159, DOI 10.1093/geront/gnx050
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   McCreight LJ, 2016, DIABETOLOGIA, V59, P426, DOI 10.1007/s00125-015-3844-9
   Meng XM, 2017, EUR REV MED PHARMACO, V21, P2232
   Montandon SA, 2017, GENES-BASEL, V8, DOI 10.3390/genes8100250
   Morrison DJ, 2016, GUT MICROBES, V7, P189, DOI 10.1080/19490976.2015.1134082
   Napolitano A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100778
   Plovier H, 2017, NAT MED, V23, P107, DOI 10.1038/nm.4236
   Preiss D, 2017, DIABETES OBES METAB, V19, P356, DOI 10.1111/dom.12826
   Pyra KA, 2012, J NUTR, V142, P213, DOI 10.3945/jn.111.147132
   Rena G, 2017, DIABETOLOGIA, V60, P1577, DOI 10.1007/s00125-017-4342-z
   Rodriguez-Carrio J, 2017, FRONT IMMUNOL, V8, DOI 10.3389/fimmu.2017.00823
   Ryan PM, 2017, DIABETOL METAB SYNDR, V9, DOI 10.1186/s13098-017-0299-9
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Wu TZ, 2017, EXPERT REV GASTROENT, V11, P157, DOI 10.1080/17474124.2017.1273769
   Wu TZ, 2017, DIABETES OBES METAB, V19, P290, DOI 10.1111/dom.12812
   Zhang XQ, 2015, SCI REP-UK, V5, DOI 10.1038/srep10737
   Zhou ZY, 2016, ACTA PHARMACOL SIN, V37, P1063, DOI 10.1038/aps.2016.21
NR 39
TC 63
Z9 65
U1 0
U2 48
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1363-1950
EI 1473-6519
J9 CURR OPIN CLIN NUTR
JI Curr. Opin. Clin. Nutr. Metab. Care
PD JUL
PY 2018
VL 21
IS 4
BP 294
EP 301
DI 10.1097/MCO.0000000000000468
PG 8
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA GI3WA
UT WOS:000434301500012
PM 29634493
DA 2023-06-08
ER

PT J
AU Huang, XW
   Hong, XL
   Wang, JL
   Sun, TT
   Yu, TC
   Yu, YN
   Fang, JY
   Xiong, H
AF Huang, Xiaowen
   Hong, Xialu
   Wang, Jilin
   Sun, Tiantian
   Yu, TaChung
   Yu, Yanan
   Fang, Jingyuan
   Xiong, Hua
TI Metformin elicits antitumour effect by modulation of the gut microbiota
   and rescues Fusobacterium nucleatum-induced colorectal tumourigenesis
SO EBIOMEDICINE
LA English
DT Article
DE Colorectal cancer; Metformin; Microbiome; Fusobacterium nucleatum
ID IN-VITRO; ALTERS; EXPRESSION; BERBERINE; PROFILES; BACTERIA; IMPACT
AB Background: The effect of metformin on gut microbiota has been reported, but whether metformin can suppress colorectal cancer (CRC) by affecting gut microbiota composition and rescue F. nucleatum-induced tumourigenicity remains unclear.
   Methods: To identify microbiota associated with both CRC occurrence and metformin treatment, first, we reanalyzed the gut microbiome of our previous data on two human cohorts of normal and CRC individuals. Subsequently, we summarized microbiota altered by metformin from published literatures. Several taxa, including Fusobacterium, were associated with both CRC occurrence and metformin treatment. We investigated the effect of metformin on APC(Min/+) mice given with or without F. nucleatum. 16S rRNA gene sequencing was performed.
   Findings: We summarized 131 genera altered by metformin from 18 published literatures. Five genera reported to be changed by metformin, including Bacteroides, Streptococcus, Achromobacter, Alistipes and Fusobacterium, were associated with CRC in both of our human cohorts. Metformin relieved the symptoms caused by F. nucleatum administration in APC(Min/+) mice, and showed promise in suppressing intestinal tumour formation and rescuing F. nucleatum-induced tumourigenicity. Administration of F. nucleatum and/or metformin had effect on gut microbiome structure, composition and functions of APC(Min/+) mice.
   Interpretation: This study pioneers in predicting critical CRC-associated taxa contributing to the antitumour effect of metformin, and correlating gut microbiome with the antitumour effect of metformin in experimental animals. We presented a basis for future investigations into metformin's potential effect on suppressing F. nucleatum-induced tumor formation in vivo. (C) 2020 The Authors. Published by Elsevier B.V.
C1 [Huang, Xiaowen; Hong, Xialu; Wang, Jilin; Sun, Tiantian; Yu, TaChung; Fang, Jingyuan; Xiong, Hua] Shanghai Jiao Tong Univ, Renji Hosp,Minist Hlth, Sch Med,State Key Lab Oncogenes & Related Genes,K, Shanghai Inst Digest Dis,Div Gastroenterol & Hepa, 145 Middle Shandong Rd, Shanghai 200001, Peoples R China.
   [Yu, Yanan] Qingdao Univ, Affiliated Hosp, Dept Gastroenterol, Qingdao 266003, Shandong, Peoples R China.
C3 Shanghai Jiao Tong University; Qingdao University
RP Fang, JY; Xiong, H (通讯作者)，Shanghai Jiao Tong Univ, Renji Hosp,Minist Hlth, Sch Med,State Key Lab Oncogenes & Related Genes,K, Shanghai Inst Digest Dis,Div Gastroenterol & Hepa, 145 Middle Shandong Rd, Shanghai 200001, Peoples R China.
EM JY.Fang@sjtu.edu.cn; huaxong88@126.com
RI Yu, Yan/GYV-4514-2022
FU National Natural Science Foundation of China [31701250]
FX This work was supported by grants from the National Natural Science
   Foundation of China (31701250).
CR Abu-Ghazaleh N, 2021, J GASTROEN HEPATOL, V36, P75, DOI 10.1111/jgh.15042
   Adeshirlarijaney A, 2019, AM J PHYSIOL-ENDOC M, V317, pE1121, DOI 10.1152/ajpendo.00245.2019
   Anders S., 2010, GENOME BIOL, V11, pR106, DOI [DOI 10.1186/GB-2010-11-10-R106, 10.1186/gb-2010-11-10-r106, DOI 10.1186/gb-2010-11-10-r106]
   [Anonymous], 2012, NATURE, V487, P330, DOI [10.1038/nature11252, DOI 10.1038/NATURE11252]
   Asshauer KP, 2015, BIOINFORMATICS, V31, P2882, DOI 10.1093/bioinformatics/btv287
   Balvociute M, 2017, BMC GENOMICS, V18, DOI 10.1186/s12864-017-3501-4
   Bauer PV, 2018, CELL METAB, V27, P101, DOI 10.1016/j.cmet.2017.09.019
   Boleij A, 2011, CLIN INFECT DIS, V53, P870, DOI 10.1093/cid/cir609
   Borges-Canha M, 2015, REV ESP ENFERM DIG, V107, P659, DOI 10.17235/reed.2015.3830/2015
   Bray Freddie, 2018, CA Cancer J Clin, V68, P394, DOI 10.3322/caac.21492
   Bryrup T, 2019, DIABETOLOGIA, V62, P1024, DOI 10.1007/s00125-019-4848-7
   Bullman S, 2017, SCIENCE, V358, P1443, DOI 10.1126/science.aal5240
   Castellarin M, 2012, GENOME RES, V22, P299, DOI 10.1101/gr.126516.111
   Dai ZW, 2018, MICROBIOME, V6, DOI 10.1186/s40168-018-0451-2
   De Caceres M, 2010, OIKOS, V119, P1674, DOI 10.1111/j.1600-0706.2010.18334.x
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Ejtahed HS, 2019, EUR J ENDOCRINOL, V180, P165, DOI [10.1530/EJE-18-0826, 10.1530/eje-18-0826]
   Elbere I, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0204317
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Fujimori T, 2015, ONCOL REP, V34, P2987, DOI 10.3892/or.2015.4284
   Gagnaire A, 2017, NAT REV MICROBIOL, V15, P109, DOI 10.1038/nrmicro.2016.171
   Gao K, 2018, PHARMACOL RES, V130, P93, DOI 10.1016/j.phrs.2018.01.011
   Haruki K, 2020, J PATHOL, V250, P397, DOI 10.1002/path.5381
   Hidalgo-Cantabrana C, 2017, MICROBIOL SPECTR, V5, DOI 10.1128/microbiolspec.BAD-0010-2016
   Higurashi T, 2016, LANCET ONCOL, V17, P475, DOI 10.1016/S1470-2045(15)00565-3
   Ji SQ, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00704
   Kanehisa M, 2000, NUCLEIC ACIDS RES, V28, P27, DOI 10.1093/nar/28.1.27
   Kato K, 2012, MOL CANCER THER, V11, P549, DOI 10.1158/1535-7163.MCT-11-0594
   Kostic AD, 2012, GENOME RES, V22, P292, DOI 10.1101/gr.126573.111
   Lagkouvardos I, 2017, PEERJ, V5, DOI 10.7717/peerj.2836
   Langille MGI, 2013, NAT BIOTECHNOL, V31, P814, DOI 10.1038/nbt.2676
   Lee H, 2018, GUT MICROBES, V9, P155, DOI 10.1080/19490976.2017.1405209
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Li T., 2019, GUT
   Liang QY, 2017, CLIN CANCER RES, V23, P2061, DOI 10.1158/1078-0432.CCR-16-1599
   Liu GM, 2018, INT J BIOL MACROMOL, V115, P711, DOI 10.1016/j.ijbiomac.2018.04.127
   Love MI, 2014, GENOME BIOL, V15, DOI 10.1186/s13059-014-0550-8
   Ma W, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.01336
   Maier L, 2018, NATURE, V555, P623, DOI 10.1038/nature25979
   Meinicke P, 2015, BIOINFORMATICS, V31, P1382, DOI 10.1093/bioinformatics/btu843
   Nakatsu G, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms9727
   Paleari L, 2018, GASTROENTEROLOGY, V154, P1543, DOI 10.1053/j.gastro.2017.12.040
   Robin X, 2011, BMC BIOINFORMATICS, V12, DOI 10.1186/1471-2105-12-77
   Segata N, 2011, GENOME BIOL, V12, DOI 10.1186/gb-2011-12-6-r60
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Tang RQ, 2018, GUT, V67, P534, DOI 10.1136/gutjnl-2016-313332
   Tomimoto A, 2008, CANCER SCI, V99, P2136, DOI 10.1111/j.1349-7006.2008.00933.x
   Tong XL, 2018, MBIO, V9, DOI 10.1128/mBio.02392-17
   Wirbel J, 2019, NAT MED, V25, P679, DOI 10.1038/s41591-019-0406-6
   Wong SH, 2017, GUT, V66, P1441, DOI 10.1136/gutjnl-2016-312766
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Wu SG, 2003, GASTROENTEROLOGY, V124, P392, DOI 10.1053/gast.2003.50047
   Wu SG, 2007, J CELL SCI, V120, P1944, DOI 10.1242/jcs.03455
   Xie JY, 2020, P NATL ACAD SCI USA, V117, P13012, DOI 10.1073/pnas.1918845117
   Xie YH, 2017, EBIOMEDICINE, V25, P32, DOI 10.1016/j.ebiom.2017.10.005
   Yang YZ, 2017, GASTROENTEROLOGY, V152, P851, DOI 10.1053/j.gastro.2016.11.018
   Yu TC, 2017, CELL, V170, P548, DOI 10.1016/j.cell.2017.07.008
   Yu YN, 2015, ONCOTARGET, V6, P32013, DOI 10.18632/oncotarget.5166
   Zagato E, 2020, NAT MICROBIOL, V5, P511, DOI 10.1038/s41564-019-0649-5
   Zhang FH, 2019, ENDOCRINE, V66, P485, DOI 10.1007/s12020-019-02041-5
   Zhang MC, 2019, BMJ OPEN DIAB RES CA, V7, DOI 10.1136/bmjdrc-2019-000717
   Zhang X, 2015, SCI REP-UK, V5, DOI 10.1038/srep14405
NR 63
TC 24
Z9 26
U1 6
U2 19
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2352-3964
J9 EBIOMEDICINE
JI EBioMedicine
PD NOV
PY 2020
VL 61
AR 103037
DI 10.1016/j.ebiom.2020.103037
PG 16
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA QK2JN
UT WOS:000620208300013
PM 33039709
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Bonnet, F
   Scheen, A
AF Bonnet, Fabrice
   Scheen, Andre
TI Understanding and overcoming metformin gastrointestinal intolerance
SO DIABETES OBESITY & METABOLISM
LA English
DT Review
DE gastrointestinal intolerance; metformin; microbiota; type 2 diabetes
   mellitus
ID EXTENDED-RELEASE METFORMIN; TYPE-2 DIABETES-MELLITUS; ALL-CAUSE
   MORTALITY; CATION TRANSPORTER 1; COMBINATION THERAPY; OPEN-LABEL;
   CLINICAL PHARMACOKINETICS; CARDIOVASCULAR OUTCOMES; GLYCEMIC CONTROL;
   DOUBLE-BLIND
AB Metformin is the most widely prescribed drug for patients with type 2 diabetes mellitus and the first-line pharmacological option as supported by multiple international guidelines, yet a rather large proportion of patients cannot tolerate metformin in adequate amounts because of its associated gastrointestinal (GI) adverse events (AEs). GI AEs typically encountered with metformin therapy include diarrhoea, nausea, flatulence, indigestion, vomiting and abdominal discomfort, with diarrhoea and nausea being the most common. Although starting at a low dose and titrating slowly may help prevent some GI AEs associated with metformin, some patients are unable to tolerate metformin at all and it may also be difficult to convince patients to start metformin again after a bout of GI AEs. Despite this clinical importance, the underlying mechanisms of the GI intolerance associated with metformin are poorly known. In the present review, we discuss: the epidemiology of metformin-associated GI intolerance and its underlying mechanisms; genotype variability and associated factors affecting metformin GI intolerance, such as comorbidities, co-medications and bariatric surgery; clinical consequences and therapeutic strategies to overcome metformin GI intolerance. These strategies include appropriate titration of immediate-release metformin, use of extended-release metformin, the promise of delayed-release metformin and gut microbiome modulators, as well as alternative pharmacological therapies when metformin cannot be tolerated at all. Given the available data, all efforts should be made to maintain metformin before considering a shift to another drug therapy.
C1 [Bonnet, Fabrice] CHU Rennes, Dept Endocrinol Diabet & Nutr, Rennes, France.
   [Scheen, Andre] Univ Liege, CIRM, CHU,Div Clin Pharmacol, Dept Endocrinol Diabet & Nutr, Liege, Belgium.
   [Scheen, Andre] Univ Liege, CHU, Dept Med, Div Diabet Nutr & Metab Disorders, Liege, Belgium.
C3 CHU Rennes; Universite de Rennes; University of Liege; University of
   Liege
RP Scheen, A (通讯作者)，Univ Liege, CHU Sart Tilman B35, CIRM, Div Clin Pharmacol, B-4000 Liege, Belgium.
EM andre.scheen@chu.ulg.ac.be
RI Bonnet, Fabrice/G-4255-2017
OI Bonnet, Fabrice/0000-0001-9255-8228
FU Merck & Co., Inc., Kenilworth, NJ, USA
FX Unrestricted financial support for a medical writer for the preparation
   of this article was provided by Merck & Co., Inc., Kenilworth, NJ, USA.
   The sponsor was not involved in any aspect of the content, writing, or
   review of the manuscript.
CR Rojas LBA, 2013, DIABETOL METAB SYNDR, V5, DOI 10.1186/1758-5996-5-6
   Andujar-Plata P, 2012, DIABETES RES CLIN PR, V95, P1, DOI 10.1016/j.diabres.2011.09.022
   Bahne E, 2016, DIABETES OBES METAB, V18, P955, DOI 10.1111/dom.12697
   Bailey CJ, 2008, DIABETOLOGIA, V51, P1552, DOI 10.1007/s00125-008-1053-5
   BAILEY CJ, 1994, BRIT J PHARMACOL, V112, P671, DOI 10.1111/j.1476-5381.1994.tb13128.x
   Blonde L, 2004, CURR MED RES OPIN, V20, P565, DOI 10.1185/030079904125003278
   Blonde L, 2012, ADV THER, V29, P1, DOI 10.1007/s12325-011-0094-1
   BONORA E, 1984, CURR MED RES OPIN, V9, P47, DOI 10.1185/03007998409109558
   Burton Jeffrey H, 2015, J Diabetes Sci Technol, V9, P808, DOI 10.1177/1932296815577425
   Buse JB, 2016, DIABETES CARE, V39, P198, DOI 10.2337/dc15-0488
   Bybel B, 2011, CLIN NUCL MED, V36, P452, DOI 10.1097/RLU.0b013e318217399e
   Chacra AR, 2014, AM J THER, V21, P198, DOI 10.1097/MJT.0b013e318235f1bb
   DANDONA P, 1983, DIABETES CARE, V6, P472, DOI 10.2337/diacare.6.5.472
   Davidson J, 2004, BR J DIABETES VASC D, V4, P273, DOI DOI 10.1177/14746514040040041101
   DEFRONZO RA, 1995, NEW ENGL J MED, V333, P541, DOI 10.1056/NEJM199508313330902
   DeFronzo RA, 2016, DIABETOLOGIA, V59, P1645, DOI 10.1007/s00125-016-3992-6
   DeFronzo RA, 2009, DIABETES, V58, P773, DOI 10.2337/db09-9028
   Donnelly LA, 2009, DIABETES OBES METAB, V11, P338, DOI 10.1111/j.1463-1326.2008.00973.x
   Dujic T, 2016, DIABETIC MED, V33, P511, DOI 10.1111/dme.13040
   Dujic T, 2015, DIABETES, V64, P1786, DOI 10.2337/db14-1388
   Florez H, 2010, POSTGRAD MED, V122, P112, DOI 10.3810/pgm.2010.03.2128
   Foretz M, 2014, CELL METAB, V20, P953, DOI 10.1016/j.cmet.2014.09.018
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Foss MT, 2001, PHARMACOTHERAPY, V21, P1422, DOI 10.1592/phco.21.17.1422.34430
   Fujioka K, 2005, DIABETES OBES METAB, V7, P28, DOI 10.1111/j.1463-1326.2004.00369.x
   Garber AJ, 1997, AM J MED, V103, P491, DOI 10.1016/S0002-9343(97)00254-4
   Garber AJ, 2016, ENDOCR PRACT, V22, P84, DOI 10.4158/EP151126.CS
   Gerich J, 2010, DIABETES RES CLIN PR, V90, P131, DOI 10.1016/j.diabres.2010.07.006
   Glucophage, 2009, GLUCOPHAGE METFORMIN
   Goldman-Levine JD, 2015, ANN PHARMACOTHER, V49, P688, DOI 10.1177/1060028015572653
   Graham GG, 2011, CLIN PHARMACOKINET, V50, P81, DOI 10.2165/11534750-000000000-00000
   Greenway F, 2014, BENEF MICROBES, V5, P29, DOI 10.3920/BM2012.0063
   Gruszka A., 2016, BR J MED MED RES, V13
   Guo LX, 2016, DIABETES METAB SYND, V10, P137, DOI 10.1016/j.dsx.2016.01.004
   Hazel-Fernandez L, 2015, CURR MED RES OPIN, V31, P1703, DOI 10.1185/03007995.2015.1067194
   HEMMINGSEN B, 2013, COCHRANE DB SYST REV, DOI DOI 10.1002/14651858.CD009008.PUB2
   Henry RR, 2012, INT J CLIN PRACT, V66, P446, DOI 10.1111/j.1742-1241.2012.02911.x
   Hermans MP, 2013, DIABETES METAB, V39, P322, DOI 10.1016/j.diabet.2013.05.005
   Hermans MP, 2012, CURR MED RES OPIN, V28, P1635, DOI 10.1185/03007995.2012.735646
   Huang Y, 2015, J CLIN PHARM THER, V40, P461, DOI 10.1111/jcpt.12290
   Huang YX, 2015, DIABETES TECHNOL THE, V17, P128, DOI 10.1089/dia.2014.0203
   Hur KY, 2015, J DIABETES INVEST, V6, P600, DOI 10.1111/jdi.12328
   International Diabetes Federation, 2012, GLOB GUID TYP 2 DIAB
   Inzucchi SE, 2015, DIABETOLOGIA, V58, P429, DOI 10.1007/s00125-014-3460-0
   Irons BK, 2014, DIABETES METAB SYNDR, V7, P15, DOI 10.2147/DMSO.S38753
   Jabbour S, 2011, POSTGRAD MED, V123, P15, DOI 10.3810/pgm.2011.01.2241
   Ji LN, 2016, DIABETES OBES METAB, V18, P775, DOI 10.1111/dom.12667
   Joshi SR, 2015, EXPERT OPIN PHARMACO, V16, P597, DOI 10.1517/14656566.2015.1009894
   Kahn SE, 2006, NEW ENGL J MED, V355, P2427, DOI 10.1056/NEJMoa066224
   Lawrence DB, 2006, J MANAGE CARE PHARM, V12, P466
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Marso SP, 2016, NEW ENGL J MED, V375, P311, DOI 10.1056/NEJMoa1603827
   Maruthur NM, 2016, ANN INTERN MED, V164, P740, DOI 10.7326/M15-2650
   McCreight LJ, 2016, DIABETOLOGIA, V59, P426, DOI 10.1007/s00125-015-3844-9
   Medical Dictionary for Regulatory Activities, 2016, DIARRH
   Montgomery AA, 2001, QUAL HEALTH CARE, V10, pI39
   Morgan CL, 2014, DIABETES OBES METAB, V16, P957, DOI 10.1111/dom.12302
   Napolitano A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100778
   Nauck M, 2013, DIABETES OBES METAB, V15, P204, DOI 10.1111/dom.12012
   NICE guidelines, 2015, TYP 2 DIAB AD MAN
   Nichols GA, 2015, DIABETES OBES METAB, V17, P843, DOI 10.1111/dom.12476
   Padwal RS, 2011, DIABETES CARE, V34, P1295, DOI 10.2337/dc10-2140
   Pala L, 2014, J ENDOCRINOL INVEST, V37, P497, DOI 10.1007/s40618-014-0065-x
   Palmer SC, 2016, JAMA-J AM MED ASSOC, V316, P313, DOI 10.1001/jama.2016.9400
   Phung OJ, 2013, DIABETIC MED, V30, P1160, DOI 10.1111/dme.12232
   Pladevall M, 2004, DIABETES CARE, V27, P2800, DOI 10.2337/diacare.27.12.2800
   RACGP and DA (Royal Australian College of General Practitioners and Diabetes Australia), 2014, GEN PRACT MAN TYP 2
   Reasner C, 2011, DIABETES OBES METAB, V13, P644, DOI 10.1111/j.1463-1326.2011.01390.x
   Rebello CJ, 2015, J DIABETES COMPLICAT, V29, P1272, DOI 10.1016/j.jdiacomp.2015.08.023
   Rena G, 2013, DIABETOLOGIA, V56, P1898, DOI 10.1007/s00125-013-2991-0
   Richeldi L, 2014, NEW ENGL J MED, V370, P2071, DOI 10.1056/NEJMoa1402584
   Rosenstock J, 1998, DIABETES CARE, V21, P2050, DOI 10.2337/diacare.21.12.2050
   Roumie CL, 2012, ANN INTERN MED, V157, P601, DOI 10.7326/0003-4819-157-9-201211060-00003
   Scarpello JHB, 1998, DIABETIC MED, V15, P651, DOI 10.1002/(SICI)1096-9136(199808)15:8<651::AID-DIA628>3.0.CO;2-A
   Scheen AJ, 2012, DIABETES METAB, V38, P89, DOI 10.1016/j.diabet.2011.11.001
   Scheen AJ, 1998, DRUGS, V55, P225
   Scheen AJ, 1996, CLIN PHARMACOKINET, V30, P359, DOI 10.2165/00003088-199630050-00003
   Scheen AJ, 2016, DIABETES METAB, V42, P71, DOI 10.1016/j.diabet.2015.12.005
   Scheen AJ, 2015, EXPERT OPIN PHARMACO, V16, P43, DOI 10.1517/14656566.2015.978289
   Schwartz S, 2006, DIABETES CARE, V29, P759, DOI 10.2337/diacare.29.04.06.dc05-1967
   Shillington AC, 2015, PATIENT PREFER ADHER, V9, P609, DOI 10.2147/PPA.S82555
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Shyangdan Deepson S, 2016, BMJ Open, V6, pe009417, DOI 10.1136/bmjopen-2015-009417
   Society CD, 2010, CHIN GUID TYP 2 DIAB
   Stepensky D, 2002, DRUG METAB DISPOS, V30, P861, DOI 10.1124/dmd.30.8.861
   Tarasova L, 2012, PHARMACOGENET GENOM, V22, P659, DOI 10.1097/FPC.0b013e3283561666
   TUCKER GT, 1981, BRIT J CLIN PHARMACO, V12, P235
   Turner RC, 1998, LANCET, V352, P854, DOI 10.1016/s0140-6736(98)07037-8
   TZOULAKI I, 2009, BMJ-BRIT MED J, V339, pb4731, DOI DOI 10.1136/BMJ.B4731
   Umpierrez G, 2014, DIABETES CARE, V37, P2168, DOI 10.2337/dc13-2759
   Viollet B, 2012, CLIN SCI, V122, P253, DOI 10.1042/CS20110386
   Weng JP, 2015, DIABETES-METAB RES, V31, P155, DOI 10.1002/dmrr.2576
   Weymann N, 2013, PATIENT PREFER ADHER, V7, P1091, DOI 10.2147/PPA.S46924
   Wu D, 2014, DIABETES OBES METAB, V16, P30, DOI 10.1111/dom.12174
   Yang WY, 2014, LANCET DIABETES ENDO, V2, P46, DOI 10.1016/S2213-8587(13)70021-4
   Zinman B, 2015, NEW ENGL J MED, V373, P2117, DOI 10.1056/NEJMoa1504720
NR 96
TC 102
Z9 107
U1 1
U2 40
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1462-8902
EI 1463-1326
J9 DIABETES OBES METAB
JI Diabetes Obes. Metab.
PD APR
PY 2017
VL 19
IS 4
BP 473
EP 481
DI 10.1111/dom.12854
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EO3SN
UT WOS:000396614700001
PM 27987248
DA 2023-06-08
ER

PT J
AU Diaz-Perdigones, CM
   Munoz-Garach, A
   Alvarez-Bermudez, MD
   Moreno-Indias, I
   Tinahones, FJ
AF Diaz-Perdigones, Cristina Ma
   Munoz-Garach, Araceli
   Dolores Alvarez-Bermudez, Maria
   Moreno-Indias, Isabel
   Tinahones, Francisco J.
TI Gut microbiota of patients with type 2 diabetes and gastrointestinal
   intolerance to metformin differs in composition and functionality from
   tolerant patients
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Metformin; Gastrointestinal; Adverse drug reactions; Gut microbiome
ID MECHANISMS; DYSBIOSIS; ACIDS
AB Objective: Metformin modifies the gut microbiome in type 2 diabetes and gastrointestinal tolerance to metformin could be mediated by the gut microbiome.
   Methods: We enrolled 35 patients with type 2 diabetes not receiving treatment with metformin due to suspected gastrointestinal intolerance. Metformin was reintroduced at 425 mg, increasing 425 mg every two weeks until reaching 1700 mg per day. According to the occurrence of metformin-related gastrointestinal symptoms, patients were classified into three groups: early intolerance, non-tolerant, and tolerant. Gut microbiota was profiled with 16 S rRNA. This sequencing aimed to determine the differences in the baseline gut microbiota in all groups and prospectively in the tolerant and non-tolerant groups.
   Results: The classification resulted in 15 early intolerant, 10 tolerant, and 10 non-tolerant subjects. Early tolerance was characterized by a higher abundance of Subdoligranulum; while Veillonella and Serratia were higher in the non-tolerant group. The tolerant group showed enrichment of Megamonas, Megamonas rupellensis, and Phascolarctobacterium spp; Ruminococcus gnavus was lower in the longitudinal analysis. At the end point Prevotellaceae, Prevotella stercorea, Megamonas funiformis, Bacteroides xylanisolvens, and Blautia producta had a higher relative abundance in the tolerant group compared to the non-tolerant group. Subdoligranulum, Ruminococcus torques_1, Phascolarctobacterium faecium, and Eubacterium were higher in the non-tolerant group. The PICRUSt analysis showed a lower activity of the amino acid biosynthesis pathways and a higher sugar degradation pathway in the intolerant groups.
   Conclusions: Gut microbiota of subjects with gastrointestinal intolerance depicted taxonomic and functional differences compared to tolerant patients, and this changed differently after metformin administration
C1 [Diaz-Perdigones, Cristina Ma; Munoz-Garach, Araceli; Dolores Alvarez-Bermudez, Maria; Moreno-Indias, Isabel; Tinahones, Francisco J.] Univ Malaga, Virgen de la Victoria Univ Hosp, Lab Biomed Res Inst Malaga, Clin Management Unit Endocrinol & Nutr, Malaga, Spain.
   [Diaz-Perdigones, Cristina Ma; Dolores Alvarez-Bermudez, Maria; Tinahones, Francisco J.] Univ Malaga, Program Biomed Translat Res & New Technol, Malaga, Spain.
   [Dolores Alvarez-Bermudez, Maria; Moreno-Indias, Isabel; Tinahones, Francisco J.] Inst Salud Carlos III, Ctr Invest Biomed Red CIBER Fisiopatol Obesidad &, Madrid, Spain.
C3 Hospital Virgen de la Victoria; Instituto de Investigacion Biomedica de
   Malaga y Plataforma en Nanomedicina (IBIMA); Universidad de Malaga;
   Universidad de Malaga; CIBER - Centro de Investigacion Biomedica en Red;
   CIBEROBN; Instituto de Salud Carlos III
RP Moreno-Indias, I; Tinahones, FJ (通讯作者)，Univ Malaga, Virgen de la Victoria Univ Hosp, Lab Biomed Res Inst Malaga, Clin Management Unit Endocrinol & Nutr, Malaga, Spain.
EM isabel.moreno@ibima.eu; fjtinahones@uma.es
RI Moreno-Indias, Isabel/B-6595-2017
OI Moreno-Indias, Isabel/0000-0002-6121-151X; Tinahones, Francisco
   J/0000-0001-6871-4403; Diaz Perdigones, Cristina
   Maria/0000-0002-0808-2616
FU Miguel Servet Type I program of the Carlos III Health Institute
   [CP16/00163]; "Network of Centers for Biomedical Research" (CIBER) of
   the Carlos III Health Institute (ISCIII) [CB06/03/0018]; ISCIII
   [PI18/01160]; Regional Development Fund (ERDF); Spanish Diabetes Society
FX This study was supported by the Miguel Servet Type I program of the
   Carlos III Health Institute (co-founded by the European Regional
   Development Fund) (CP16/00163 to IM-I) . In addition, this study was
   supported by the "Network of Centers for Biomedical Research" (CIBER) of
   the Carlos III Health Institute (ISCIII) (CB06/03/0018) , research
   grants from the ISCIII (PI18/01160) and co-financed by the Regional
   Development Fund (ERDF) . Finally, this study was also undertaken with
   the aid of a grant from the Spanish Diabetes Society to help the
   development of young researchers.
CR Bailey CJ, 2017, DIABETOLOGIA, V60, P1566, DOI 10.1007/s00125-017-4318-z
   Benitez-Paez A, 2020, MSYSTEMS, V5, DOI 10.1128/mSystems.00857-19
   Bolyen E, 2019, NAT BIOTECHNOL, V37, P852, DOI 10.1038/s41587-019-0209-9
   Bonnet F, 2017, DIABETES OBES METAB, V19, P473, DOI 10.1111/dom.12854
   Bryrup T, 2019, DIABETOLOGIA, V62, P1024, DOI 10.1007/s00125-019-4848-7
   Callahan BJ, 2016, NAT METHODS, V13, P581, DOI [10.1038/NMETH.3869, 10.1038/nmeth.3869]
   Canfora EE, 2015, NAT REV ENDOCRINOL, V11, P577, DOI 10.1038/nrendo.2015.128
   Caspi R, 2018, NUCLEIC ACIDS RES, V46, pD633, DOI 10.1093/nar/gkx935
   Chong J, 2020, NAT PROTOC, V15, P799, DOI 10.1038/s41596-019-0264-1
   Crusell MKW, 2018, MICROBIOME, V6, DOI 10.1186/s40168-018-0472-x
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Foretz M, 2014, CELL METAB, V20, P953, DOI 10.1016/j.cmet.2014.09.018
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Gurung M, 2020, EBIOMEDICINE, V51, DOI 10.1016/j.ebiom.2019.11.051
   Hall AB, 2017, GENOME MED, V9, DOI 10.1186/s13073-017-0490-5
   Henke MT, 2019, P NATL ACAD SCI USA, V116, P12672, DOI 10.1073/pnas.1904099116
   Higuchi BS, 2018, FRONT IMMUNOL, V9, DOI 10.3389/fimmu.2018.01689
   Inoue R, 2017, J CLIN BIOCHEM NUTR, V61, P217, DOI 10.3164/jcbn.17-44
   Jalanka J, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20020433
   Label O., 2018, CROSSM STRUCTURAL AL, V9, P1
   Lee H, 2018, GERONTOLOGIST, V58, P159, DOI 10.1093/geront/gnx050
   Leiva-Gea I, 2018, DIABETES CARE, V41, P2385, DOI 10.2337/dc18-0253
   Li HJ, 2019, MICROORGANISMS, V7, DOI 10.3390/microorganisms7100399
   Li L, 2016, NEUROGASTROENT MOTIL, V28, P1233, DOI 10.1111/nmo.12822
   Li XQ, 2018, NUTRIENTS, V10, DOI 10.3390/nu10101403
   Mardinoglu A, 2016, CELL METAB, V23, P10, DOI 10.1016/j.cmet.2015.12.012
   McCreight LJ, 2018, DIABETES OBES METAB, V20, P1593, DOI 10.1111/dom.13264
   McCreight LJ, 2016, DIABETOLOGIA, V59, P426, DOI 10.1007/s00125-015-3844-9
   Nakajima H, 2020, LIFE-BASEL, V10, DOI 10.3390/life10090195
   Ottosson F, 2018, J CLIN ENDOCR METAB, V103, P1491, DOI 10.1210/jc.2017-02114
   Panasevich MR, 2016, AM J PHYSIOL-GASTR L, V311, pG166, DOI 10.1152/ajpgi.00065.2016
   Parks DH, 2014, BIOINFORMATICS, V30, P3123, DOI 10.1093/bioinformatics/btu494
   Pedersen RM, 2013, ANAEROBE, V24, P1, DOI 10.1016/j.anaerobe.2013.08.004
   Preiss D, 2016, DIABETIC MED, V33, P1569, DOI 10.1111/dme.13097
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Rena G, 2017, DIABETOLOGIA, V60, P1577, DOI 10.1007/s00125-017-4342-z
   Rodriguez-Carrio J, 2017, FRONT IMMUNOL, V8, DOI 10.3389/fimmu.2017.00823
   Rosario D, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.00775
   Sampaio C., 2015, CELL HOSTE MICROBE, V155, P1683, DOI [10.1016/j.pain.2014.05.025, DOI 10.1016/J.PAIN.2014.05.025]
   Sansome DJ, 2020, DIABETES OBES METAB, V22, P141, DOI 10.1111/dom.13869
   Segata N, 2011, GENOME BIOL, V12, DOI 10.1186/gb-2011-12-6-r60
   Van Hul M, 2020, GUT MICROBES, V12, P1, DOI 10.1080/19490976.2020.1849998
   Wu FF, 2017, EXP THER MED, V14, P3122, DOI 10.3892/etm.2017.4878
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
NR 44
TC 8
Z9 8
U1 3
U2 16
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD JAN
PY 2022
VL 145
AR 112448
DI 10.1016/j.biopha.2021.112448
EA NOV 2021
PG 9
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA XG9AG
UT WOS:000725038200003
PM 34844104
OA gold
DA 2023-06-08
ER

PT J
AU Huang, YX
   Lou, XD
   Jiang, CP
   Ji, XY
   Tao, XM
   Sun, J
   Bao, ZJ
AF Huang, Yuxin
   Lou, Xudan
   Jiang, Cuiping
   Ji, Xueying
   Tao, Xiaoming
   Sun, Jiao
   Bao, Zhijun
TI Gut microbiota is correlated with gastrointestinal adverse events of
   metformin in patients with type 2 diabetes
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE type 2 diabetes; metformin; gastrointestinal adverse events; gut
   microbiota; short-chain fatty acids (SCFAs)
ID GLUCAGON-LIKE PEPTIDE-1; CHAIN FATTY-ACIDS; INTOLERANCE; TOLERANCE;
   SECRETION; HEIGHT
AB AimGastrointestinal discomfort is the most common adverse event in metformin treatment for type 2 diabetes. The mechanism of action of metformin is associated with gut microbiota. However, the gut microbial community structure related to metformin-induced gastrointestinal adverse events remains unclear. This study aimed to investigate it. Methods50 patients with newly diagnosed diabetes were treated with metformin 1500mg/d for 12 weeks. The patients were divided into two groups according to whether gastrointestinal adverse events occurred (group B) or did not occur (group A) after treatment. The fecal bacterial communities and short-chain fatty acids (SCFAs) were sequenced and compared. 70 diabetes mice were randomly divided into 8 groups and treated with metformin (Met), clindamycin (Clin) and/or SCFA, which were the Met+/Clin+, Met+/Clin-, Met-/Clin+, Met-/Clin-, Met+/SCFA+, Met+/SCFA-, Met-/SCFA+ and Met-/SCFA- group. After 4 weeks of metformin treatment, blood glucose, food intake, fecal SCFAs, gut microbiota and gut hormones were measured. ResultsMetformin increased the abundance of Phascolarctobacterium, Intestinimonas and Clostridium III. Functional prediction analysis showed that the propanoate metabolism pathway was significantly up-regulated. The concentrations of acetic acid and propanoic acid in feces were significantly increased. The abundance of Clostridium sensu stricto, Streptococcus and Akkermansia induced by metformin in group B was higher than that in group A. The propanoate metabolism pathway and propanoic acid in feces were significantly up-regulated in group B. In the animal experiments, the food intake decreased and glucose control increased in metformin groups compared with those in the control groups. The total GLP-1 level in the Met+/Clin- group was significantly higher than that in the Met-/Clin- group, while there was no statistical difference between the Met-/Clin- and Met+/Clin+ group. The total GLP-1 level in the Met-/SCFA+ group was significantly higher than that in the Met-/SCFA-group, while the levels of total GLP-1 and active GLP-1 in the Met+/SCFA- group and the Met+/SCFA+ group were significantly higher than those in the Met-/SCFA-group. ConclusionsOur data suggest that metformin promotes the secretion of intestinal hormones such as GLP-1 by increasing the abundance of SCFA-producing bacteria, which not only plays an anti-diabetic role, but also may causes gastrointestinal adverse events.
C1 [Huang, Yuxin; Lou, Xudan; Jiang, Cuiping; Tao, Xiaoming; Sun, Jiao] Fudan Univ, Dept Endocrinol, Huadong Hosp, Shanghai, Peoples R China.
   [Ji, Xueying; Bao, Zhijun] Fudan Univ, Dept Gerontol, Huadong Hosp, Shanghai, Peoples R China.
C3 Fudan University; Fudan University
RP Tao, XM (通讯作者)，Fudan Univ, Dept Endocrinol, Huadong Hosp, Shanghai, Peoples R China.; Bao, ZJ (通讯作者)，Fudan Univ, Dept Gerontol, Huadong Hosp, Shanghai, Peoples R China.
EM t983166@163.com; xinyi8681@sina.com
RI Ji, Xueying/HRA-8284-2023
FU Natural Science Foundation of Xinjiang Uygur Autonomous Region;
   Scientific Research Topics of Shanghai Health and Family Planning
   Commission; Shanghai Sailing program; Key Talents Program of Huadong
   Hospital Affiliated to Fudan University;  [2021D01C025];  [20184Y0168]; 
   [21YF1411700];  [H-1068]
FX Funding Natural Science Foundation of Xinjiang Uygur Autonomous Region
   (2021D01C025); Scientific Research Topics of Shanghai Health and Family
   Planning Commission (20184Y0168); Shanghai Sailing program
   (21YF1411700). Key Talents Program of Huadong Hospital Affiliated to
   Fudan University (H-1068).
CR Bahne E, 2016, DIABETES OBES METAB, V18, P955, DOI 10.1111/dom.12697
   Beysen C, 2012, DIABETOLOGIA, V55, P432, DOI 10.1007/s00125-011-2382-3
   Bouchoucha M, 2011, DIABETES METAB, V37, P90, DOI 10.1016/j.diabet.2010.11.002
   Caturano A, 2019, JAMA-J AM MED ASSOC, V322, P1312, DOI 10.1001/jama.2019.11489
   Cefalu WT, 2019, DIABETES CARE, V42, pS90, DOI 10.2337/dc19-S009
   Cui HX, 2019, FRONT MICROBIOL, V10, DOI 10.3389/fmicb.2019.01423
   Czech MP, 2017, NAT MED, V23, P804, DOI 10.1038/nm.4350
   Dawed AY, 2019, DIABETES CARE, V42, P1027, DOI 10.2337/dc18-2182
   de la Cuesta-Zuluaga J, 2019, NUTRIENTS, V11, DOI 10.3390/nu11010051
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Duca FA, 2015, NAT MED, V21, P506, DOI 10.1038/nm.3787
   Dujic T, 2016, DIABETES CARE, V39, P1896, DOI 10.2337/dc16-0706
   Dujic T, 2015, DIABETES, V64, P1786, DOI 10.2337/db14-1388
   Edgar RC, 2011, BIOINFORMATICS, V27, P2194, DOI 10.1093/bioinformatics/btr381
   Edgar RC, 2010, BIOINFORMATICS, V26, P2460, DOI 10.1093/bioinformatics/btq461
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Freeland KR, 2010, BRIT J NUTR, V103, P460, DOI 10.1017/S0007114509991863
   Haro C, 2016, J CLIN ENDOCR METAB, V101, P232, DOI 10.1210/jc.2015-3351
   Hiel S, 2020, CLIN NUTR, V39, P3618, DOI 10.1016/j.clnu.2020.04.005
   Holman RR, 2008, NEW ENGL J MED, V359, P1577, DOI 10.1056/NEJMoa0806470
   Holodniy M, 2011, PLOS ONE, V6, DOI [10.1371/journal.pone.0014764, 10.1371/journal.pone.0025792]
   HOVERSTAD T, 1986, SCAND J GASTROENTERO, V21, P621, DOI 10.3109/00365528609003109
   Huang Y, 2015, J CLIN PHARM THER, V40, P461, DOI 10.1111/jcpt.12290
   Huang YX, 2020, J CLIN PHARM THER, V45, P470, DOI 10.1111/jcpt.13087
   Huang YX, 2015, DIABETES TECHNOL THE, V17, P128, DOI 10.1089/dia.2014.0203
   Koncz V, 2019, OBESITY, V27, P505, DOI 10.1002/oby.22394
   Li L, 2019, FOOD FUNCT, V10, P2560, DOI [10.1039/C9FO00075E, 10.1039/c9fo00075e]
   Li QZ, 2020, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00939
   Lien F, 2014, J CLIN INVEST, V124, P1037, DOI 10.1172/JCI68815
   Magoc T, 2011, BIOINFORMATICS, V27, P2957, DOI 10.1093/bioinformatics/btr507
   McCreight LJ, 2016, DIABETOLOGIA, V59, P426, DOI 10.1007/s00125-015-3844-9
   Montandon SA, 2017, GENES-BASEL, V8, DOI 10.3390/genes8100250
   Morgillo F, 2013, EXPERT OPIN INV DRUG, V22, P1401, DOI 10.1517/13543784.2013.828691
   Nesti L, 2017, NUTR METAB CARDIOVAS, V27, P657, DOI 10.1016/j.numecd.2017.04.009
   Nohr MK, 2013, ENDOCRINOLOGY, V154, P3552, DOI 10.1210/en.2013-1142
   Panasevich MR, 2016, AM J PHYSIOL-GASTR L, V311, pG166, DOI 10.1152/ajpgi.00065.2016
   Petrie JR, 2017, LANCET DIABETES ENDO, V5, P597, DOI 10.1016/S2213-8587(17)30194-8
   Psichas A, 2015, INT J OBESITY, V39, P424, DOI 10.1038/ijo.2014.153
   Rudra CB, 2007, AM J EPIDEMIOL, V165, P302, DOI 10.1093/aje/kwk007
   Salvatore T, 2021, BIOMEDICINES, V9, DOI 10.3390/biomedicines9010003
   Salvatore T, 2020, DIABETES RES CLIN PR, V160, DOI 10.1016/j.diabres.2020.108025
   Santoro AB, 2018, BRIT J CLIN PHARMACO, V84, P987, DOI 10.1111/bcp.13522
   Scarpello JHB, 1998, DIABETIC MED, V15, P651, DOI 10.1002/(SICI)1096-9136(199808)15:8<651::AID-DIA628>3.0.CO;2-A
   Sethi V, 2018, GASTROENTEROLOGY, V155, P33, DOI 10.1053/j.gastro.2018.04.001
   Shackley M, 2020, FRONT NUTR, V7, DOI 10.3389/fnut.2020.568991
   Tan KM, 2018, PROTEIN SCI, V27, P1498, DOI 10.1002/pro.3444
   Tolhurst G, 2012, DIABETES, V61, P364, DOI 10.2337/db11-1019
   Valeriano VDV, 2017, J APPL MICROBIOL, V122, P554, DOI 10.1111/jam.13364
   Wemheuer F, 2020, ENVIRON MICROBIOME, V15, DOI 10.1186/s40793-020-00358-7
   Wu TZ, 2017, DIABETES OBES METAB, V19, P290, DOI 10.1111/dom.12812
   Xiao L, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-22052-y
   Yorek MS, 2017, NEUROPHARMACOLOGY, V116, P122, DOI 10.1016/j.neuropharm.2016.12.022
   Zhang HQ, 2021, AGING-US, V13, P19013, DOI 10.18632/aging.203351
   Zhang X, 2015, SCI REP-UK, V5, DOI 10.1038/srep14405
   Zhang Y, 2016, EVID-BASED COMPL ALT, V2016, DOI 10.1155/2016/1592731
NR 55
TC 1
Z9 1
U1 3
U2 3
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD NOV 17
PY 2022
VL 13
AR 1044030
DI 10.3389/fendo.2022.1044030
PG 14
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 6S0RI
UT WOS:000892704200001
PM 36465607
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Rogall, ET
   Jacob, S
   Triebskorn, R
   Schwartz, T
AF Rogall, Eike Thorben
   Jacob, Stefanie
   Triebskorn, Rita
   Schwartz, Thomas
TI The impact of the anti-diabetic drug metformin on the intestinal
   microbiome of larval brown trout (Salmo trutta f. fario)
SO ENVIRONMENTAL SCIENCES EUROPE
LA English
DT Article
DE Microbiome; Brown trout; Metformin; Virulence
ID TRANSFORMATION PRODUCT GUANYLUREA; PERSONAL CARE PRODUCTS; WASTE-WATER;
   GUT MICROBIOME; SURFACE-WATER; PHARMACEUTICALS; ENVIRONMENT;
   MICROPOLLUTANTS; DEGRADATION; STRESSORS
AB Background The anti-diabetic pharmaceutical metformin is frequently analysed in the aquatic environment. Its impact on the fish microbiome is studied to get a deeper knowledge about the consequence of the metformin presence in river systems. Gut microbiome analyses were performed on larval brown trout with metformin including environmental concentrations. Therefore, the fish were exposed to metformin in concentrations of 0, 1, 10, 100, and 1000 mu g/L. Especially, the lower metformin concentrations were measured in river waters containing percentages of conditioned wastewater from municipal wastewater treatment plants. Results Two complementary molecular biological methods for population analysis targeting the 16S rRNA gene regions V1-V3, i.e.: (1) 16S amplicon sequencing and (2) polymerase chain reaction (PCR) combined with denaturing gradient gel electrophoresis (DGGE). Both analyses demonstrated significant microbiome alterations even at low metformin concentrations being analysed in German rivers. The amplicon sequencing revealed the most distinct shifts in the Firmicutes phylum, or more specifically, within the Bacillales order, which were most affected by metformin exposure. Within the Bacillales order, the Planococcaceae family, which is described to provide essential amino acids for the fish, completely disappeared after metformin treatment. Conversely, the percentage of other bacteria, such as Staphylococcaceae, increased after exposure to metformin. Similarity profiles of the microbiomes could be generated using the Sorensen index calculation after PCR-DGGE analyses and confirmed shifts in the composition of the brown trout intestinal microbiome after metformin exposures. In vitro gene expression analyses of virulence factors from fish pathogens, previously identified in the fish microbiomes DNA extracts, were conducted in the presence or absence of environmentally relevant concentrations. Here, marker genes of Enterococcus faecium, Enterococcus faecalis, and Aeromonas hydrophila were detected and quantified via PCR approaches, firstly. An increased expression of the species-specific virulence genes was observed after normalisation with control data and ribosomal housekeeping genes. Conclusion Environmentally relevant concentrations of metformin can alter the composition in gut microbiome of brown trout in different ways. Both, the metformin-induced expression of virulence genes in fish pathogens in vitro and the impact of metformin on the microbiome composition in vivo in larval brown trout open the discussion about a possible long-term effect on the vitality, growth, and development in more mature brown trouts.
C1 [Rogall, Eike Thorben; Schwartz, Thomas] Karlsruhe Inst Technol, Inst Funct Interfaces IFG, Hermann von Helmholtz Pl 1, D-76344 Eggenstein Leopoldshafen, Germany.
   [Jacob, Stefanie; Triebskorn, Rita] Univ Tubingen, Anim Physiol Ecol, Morgenstelle 5, D-72076 Tubingen, Germany.
C3 Helmholtz Association; Karlsruhe Institute of Technology; Eberhard Karls
   University of Tubingen
RP Schwartz, T (通讯作者)，Karlsruhe Inst Technol, Inst Funct Interfaces IFG, Hermann von Helmholtz Pl 1, D-76344 Eggenstein Leopoldshafen, Germany.
EM thomas.schwartz@kit.edu
FU Ministry for Science, Research and Arts of Baden-Wurttemberg
   [33-5733-25-11t32/2]
FX This study is funded by the Ministry for Science, Research and Arts of
   Baden-Wurttemberg (Grant no. 33-5733-25-11t32/2).
CR Al-Hisnawi A, 2015, AQUAC RES, V46, P2962, DOI 10.1111/are.12451
   Alam R, 2017, AM J MED GENET B, V174, P651, DOI 10.1002/ajmg.b.32567
   Angly FE, 2014, MICROBIOME, V2, DOI 10.1186/2049-2618-2-11
   [Anonymous], 2020, NORMAN EC DAT
   Bakke-McKellep AM, 2007, BRIT J NUTR, V97, P699, DOI 10.1017/S0007114507381397
   Bonga SEW, 1997, PHYSIOL REV, V77, P591, DOI 10.1152/physrev.1997.77.3.591
   Boone MD, 2007, ECOL APPL, V17, P291, DOI 10.1890/1051-0761(2007)017[0291:MSIACE]2.0.CO;2
   Boulard L, 2020, WATER RES, V171, DOI 10.1016/j.watres.2019.115366
   CHAO A, 1984, SCAND J STAT, V11, P265
   Cleuvers M, 2003, TOXICOL LETT, V142, P185, DOI 10.1016/S0378-4274(03)00068-7
   Daughton CG, 1999, ENVIRON HEALTH PERSP, V107, P907, DOI 10.2307/3434573
   der Beek TA, 2016, ENVIRON TOXICOL CHEM, V35, P823, DOI 10.1002/etc.3339
   DOWSE GK, 1991, DIABETES CARE, V14, P271, DOI 10.2337/diacare.14.4.271
   Edgar RC, 2011, BIOINFORMATICS, V27, P2194, DOI 10.1093/bioinformatics/btr381
   Eren AM, 2015, ISME J, V9, P968, DOI 10.1038/ismej.2014.195
   Faith DP, 2006, EVOL BIOINFORM, V2, P121
   Fanning S, 2012, P NATL ACAD SCI USA, V109, P2108, DOI 10.1073/pnas.1115621109
   Foretz M, 2014, CELL METAB, V20, P953, DOI 10.1016/j.cmet.2014.09.018
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Ghoshdastidar AJ, 2015, ENVIRON SCI POLLUT R, V22, P689, DOI 10.1007/s11356-014-3400-z
   Gomez D, 2013, FISH SHELLFISH IMMUN, V35, P1729, DOI 10.1016/j.fsi.2013.09.032
   Holmstrup M, 2010, SCI TOTAL ENVIRON, V408, P3746, DOI 10.1016/j.scitotenv.2009.10.067
   Huggett J, 2005, GENES IMMUN, V6, P279, DOI 10.1038/sj.gene.6364190
   Inzucchi SE, 2012, DIABETOLOGIA, V55, P1577, DOI 10.1007/s00125-012-2534-0
   Jacob S, 2018, ENVIRON SCI EUR, V30, DOI 10.1186/s12302-018-0179-4
   Jager T, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.02599
   Johnson KVA, 2018, NAT REV MICROBIOL, V16, P647, DOI 10.1038/s41579-018-0014-3
   Jones OAH, 2002, WATER RES, V36, P5013, DOI 10.1016/S0043-1354(02)00227-0
   Kasprzyk-Hordern B, 2008, WATER RES, V42, P3498, DOI 10.1016/j.watres.2008.04.026
   Khan S, 2002, OCCURRENCE DISTRIBUT
   Kosma CI, 2015, WATER RES, V70, P436, DOI 10.1016/j.watres.2014.12.010
   Kristensen P., 2018, EUROPEAN WATERS ASSE
   Ladiges W., 1979, SUSSWASSERFISCHE EUR
   Liu H, 2016, SCI REP-UK, V6, DOI 10.1038/srep24340
   Magoc T, 2011, BIOINFORMATICS, V27, P2957, DOI 10.1093/bioinformatics/btr507
   McCreight LJ, 2016, DIABETOLOGIA, V59, P426, DOI 10.1007/s00125-015-3844-9
   Muller H, 1983, FISCHE EUROPAS
   MUYZER G, 1993, APPL ENVIRON MICROB, V59, P695, DOI 10.1128/AEM.59.3.695-700.1993
   NORMAN, 2020, NORMAN EMPODAT DAT C
   O'Mahony SM, 2015, BEHAV BRAIN RES, V277, P32, DOI 10.1016/j.bbr.2014.07.027
   Oosterhuis M, 2013, SCI TOTAL ENVIRON, V442, P380, DOI 10.1016/j.scitotenv.2012.10.046
   Ringo E, 1999, AQUAC RES, V30, P73, DOI 10.1046/j.1365-2109.1999.00302.x
   Ringo E, 2001, J APPL MICROBIOL, V90, P294, DOI 10.1046/j.1365-2672.2001.01246.x
   Rognes T, 2016, PEERJ, V4, DOI 10.7717/peerj.2584
   Scheurer M, 2012, WATER RES, V46, P4790, DOI 10.1016/j.watres.2012.06.019
   Scheurer M, 2009, J ENVIRON MONITOR, V11, P1608, DOI 10.1039/b909311g
   Schwabe U., 2016, ARZNEIVERORDNUNGS RE
   Schwarzenbach RP, 2006, SCIENCE, V313, P1072, DOI 10.1126/science.1127291
   Sekirov I, 2010, PHYSIOL REV, V90, P859, DOI 10.1152/physrev.00045.2009
   Smith P, 2017, ELIFE, V6, DOI 10.7554/eLife.27014
   Ternes TA, 2017, ENVIRON SCI TECHNOL, V51, P308, DOI 10.1021/acs.est.6b04855
   Tisler S, 2018, SCI TOTAL ENVIRON, V628-629, P1121, DOI 10.1016/j.scitotenv.2018.02.105
   Trautwein C, 2014, ENVIRON INT, V70, P203, DOI 10.1016/j.envint.2014.05.008
   Trautwein C, 2011, CHEMOSPHERE, V85, P765, DOI 10.1016/j.chemosphere.2011.06.057
   Vandesompele J, 2002, GENOME BIOL, V3, DOI 10.1186/gb-2002-3-7-research0034
   Wang AR, 2018, REV AQUACULT, V10, P626, DOI 10.1111/raq.12191
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Wu XC, 2016, SCI REP-UK, V6, DOI 10.1038/srep19000
   Zhu LF, 2011, P NATL ACAD SCI USA, V108, P17714, DOI 10.1073/pnas.1017956108
NR 59
TC 6
Z9 6
U1 1
U2 10
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 2190-4707
EI 2190-4715
J9 ENVIRON SCI EUR
JI Environ. Sci Eur.
PD APR 22
PY 2020
VL 32
IS 1
AR 65
DI 10.1186/s12302-020-00341-6
PG 14
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA LJ2BA
UT WOS:000529974200002
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Broadfield, LA
   Saigal, A
   Szamosi, JC
   Hammill, JA
   Bezverbnaya, K
   Wang, DD
   Gautam, J
   Tsakiridis, EE
   Di Pastena, F
   McNicol, J
   Wu, JH
   Syed, S
   Lally, JSV
   Raphenya, AR
   Blouin, MJ
   Pollak, M
   Sacconi, A
   Blandino, G
   McArthur, AG
   Schertzer, JD
   Surette, MG
   Collins, SM
   Bramson, JL
   Muti, P
   Tsakiridis, T
   Steinberg, GR
AF Broadfield, Lindsay A.
   Saigal, Amna
   Szamosi, Jake C.
   Hammill, Joanne A.
   Bezverbnaya, Ksenia
   Wang, Dongdong
   Gautam, Jaya
   Tsakiridis, Evangelia E.
   Di Pastena, Fiorella
   McNicol, Jamie
   Wu, Jianhan
   Syed, Saad
   Lally, James S. V.
   Raphenya, Amogelang R.
   Blouin, Marie-Jose
   Pollak, Michael
   Sacconi, Andrea
   Blandino, Giovanni
   McArthur, Andrew G.
   Schertzer, Jonathan D.
   Surette, Michael G.
   Collins, Stephen M.
   Bramson, Jonathan L.
   Muti, Paola
   Tsakiridis, Theodoros
   Steinberg, Gregory R.
TI Metformin-induced reductions in tumor growth involves modulation of the
   gut microbiome
SO MOLECULAR METABOLISM
LA English
DT Article
DE Gut microbiome; Metformin; High-fat diet; Obesity; Colon cancer
ID CHAIN FATTY-ACIDS; METAGENOME-WIDE ASSOCIATION; INTESTINAL MICROBIOTA;
   EXPRESSION; CANCER; ALTERS
AB Background/Purpose: Type 2 diabetes and obesity increase the risk of developing colorectal cancer. Metformin may reduce colorectal cancer but the mechanisms mediating this effect remain unclear. In mice and humans, a high-fat diet (HFD), obesity and metformin are known to alter the gut microbiome but whether this is important for influencing tumor growth is not known.Methods: Mice with syngeneic MC38 colon adenocarcinomas were treated with metformin or feces obtained from control or metformin treated mice.Results: We find that compared to chow-fed controls, tumor growth is increased when mice are fed a HFD and that this acceleration of tumor growth can be partially recapitulated through transfer of the fecal microbiome or in vitro treatment of cells with fecal filtrates from HFD-fed animals. Treatment of HFD-fed mice with orally ingested, but not intraperitoneally injected, metformin suppresses tumor growth and increases the expression of short-chain fatty acid (SCFA)-producing microbes Alistipes, Lachnospiraceae and Ruminococcaceae. The transfer of the gut microbiome from mice treated orally with metformin to drug naive, conventionalized HFD-fed mice increases circulating propionate and butyrate, reduces tumor proliferation, and suppresses the expression of sterol response element binding protein (SREBP) gene targets in the tumor.Conclusion: These data indicate that in obese mice fed a HFD, metformin reduces tumor burden through changes in the gut microbiome. (c) 2022 The Author(s). Published by Elsevier GmbH. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
C1 [Broadfield, Lindsay A.; Saigal, Amna; Wang, Dongdong; Gautam, Jaya; Tsakiridis, Evangelia E.; Di Pastena, Fiorella; Wu, Jianhan; Syed, Saad; Lally, James S. V.; McArthur, Andrew G.; Schertzer, Jonathan D.; Surette, Michael G.; Muti, Paola; Tsakiridis, Theodoros; Steinberg, Gregory R.] McMaster Univ, Ctr Metab Obes & Diabet Res, Hamilton, ON, Canada.
   [Broadfield, Lindsay A.; Wang, Dongdong; Gautam, Jaya; Tsakiridis, Evangelia E.; Di Pastena, Fiorella; Wu, Jianhan; Syed, Saad; Lally, James S. V.; Surette, Michael G.; Collins, Stephen M.; Steinberg, Gregory R.] McMaster Univ, Dept Med, Hamilton, ON, Canada.
   [Szamosi, Jake C.; Syed, Saad; Schertzer, Jonathan D.; Surette, Michael G.; Collins, Stephen M.] McMaster Univ, Farncombe Family Digest Res Inst, Hamilton, ON, Canada.
   [Hammill, Joanne A.; Bezverbnaya, Ksenia; McNicol, Jamie; Bramson, Jonathan L.] McMaster Univ, Dept Pathol & Mol Med, Hamilton, ON, Canada.
   [Szamosi, Jake C.; McArthur, Andrew G.; Schertzer, Jonathan D.; Surette, Michael G.; Steinberg, Gregory R.] McMaster Univ, Dept Biochem & Biomed Sci, Hamilton, ON, Canada.
   [Muti, Paola; Tsakiridis, Theodoros] McMaster Univ, Dept Oncol, Hamilton, ON, Canada.
   [Blouin, Marie-Jose; Pollak, Michael] Jewish Gen Hosp, Lady Davis Inst Med Res, Segal Canc Ctr, Montreal, PQ, Canada.
   [Blouin, Marie-Jose; Pollak, Michael] McGill Univ, Gerald Bronfman Dept Oncol, Montreal, PQ, Canada.
   [Blandino, Giovanni] Italian Natl Canc Inst Regina Elena, Oncogen & Epigenet Unit, Rome, Italy.
   [Steinberg, Gregory R.] HSC 4N63, 1280 Main St, Hamilton, ON L8S 4K1, Canada.
C3 McMaster University; McMaster University; McMaster University; McMaster
   University; McMaster University; McMaster University; Lady Davis
   Institute; McGill University; McGill University
RP Steinberg, GR (通讯作者)，McMaster Univ, Ctr Metab Obes & Diabet Res, Hamilton, ON, Canada.; Steinberg, GR (通讯作者)，McMaster Univ, Dept Med, Hamilton, ON, Canada.; Steinberg, GR (通讯作者)，McMaster Univ, Dept Biochem & Biomed Sci, Hamilton, ON, Canada.; Steinberg, GR (通讯作者)，HSC 4N63, 1280 Main St, Hamilton, ON L8S 4K1, Canada.
EM gsteinberg@mcmaster.ca
RI sacconi, andrea/J-3669-2018; Raphenya, Amogelang/HTR-8993-2023;
   Schertzer, Jonathan/P-3395-2017; Wang, Dongdong/P-7257-2016
OI sacconi, andrea/0000-0002-8276-0438; Raphenya,
   Amogelang/0000-0001-9259-5280; Tsakiridis,
   Theodoros/0000-0002-8675-4422; Schertzer, Jonathan/0000-0002-1547-5856;
   Wang, Dongdong/0000-0002-6195-4428; Broadfield, Lindsay
   A/0000-0002-7878-5712; Di Pastena, Fiorella/0000-0003-3509-8936
FU Canadian Cancer Society; Canadian Institutes of Health Research
   [201709FDN-CEBA-116200, 144625-1]; Diabetes Canada [DI-5-17-5302-GS]
FX Authors would like to thank Dr. Jun Han of the University of Victoria
   Genome BC Pro-teomics center, a node of The Metabolomics Innovation
   Centre (TMIC) for metabolomics measurements. G.R.S is a Canada Research
   Chair and the J. Bruce Duncan Chair in Metabolic Diseases. This study
   was supported by research grants from the Canadian Cancer Society,
   Canadian Institutes of Health Research (201709FDN-CEBA-116200 and
   144625-1 to GRS) and Diabetes Canada (DI-5-17-5302-GS) .
CR Algire C, 2011, ONCOGENE, V30, P1174, DOI 10.1038/onc.2010.483
   Algire C, 2010, ENDOCR-RELAT CANCER, V17, P351, DOI 10.1677/ERC-09-0252
   Alvaro A, 2008, IUBMB LIFE, V60, P757, DOI 10.1002/iub.110
   Angelova M, 2015, GENOME BIOL, V16, DOI 10.1186/s13059-015-0620-6
   Bachem A, 2019, IMMUNITY, V51, P285, DOI 10.1016/j.immuni.2019.06.002
   Bartram AK, 2011, APPL ENVIRON MICROB, V77, P3846, DOI 10.1128/AEM.02772-10
   Bauer PV, 2018, CELL METAB, V27, P101, DOI 10.1016/j.cmet.2017.09.019
   Bruggner RV, 2014, P NATL ACAD SCI USA, V111, pE2770, DOI 10.1073/pnas.1408792111
   Cha JH, 2018, MOL CELL, V71, P606, DOI 10.1016/j.molcel.2018.07.030
   Chandel NS, 2016, CELL METAB, V23, P569, DOI 10.1016/j.cmet.2016.03.010
   Coll AP, 2020, NATURE, V578, P444, DOI 10.1038/s41586-019-1911-y
   Day EA, 2019, NAT METAB, V1, P1202, DOI 10.1038/s42255-019-0146-4
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   De Vadder F, 2014, CELL, V156, P84, DOI 10.1016/j.cell.2013.12.016
   Ding X, 2019, AM J CANCER RES, V9, P219
   Dong YL, 2017, BIOSCIENCE REP, V37, DOI [10.1042/BSR20170945, 10.1042/bsr20170945]
   Dowling RJO, 2016, CELL METAB, V23, P567, DOI 10.1016/j.cmet.2016.03.006
   Dowling RJO, 2011, BMC MED, V9, DOI 10.1186/1741-7015-9-33
   Efremova M, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-017-02424-0
   Feng Q, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms7528
   Flemer B, 2017, GUT, V66, P633, DOI 10.1136/gutjnl-2015-309595
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Garber AJ, 2015, ENDOCR PRACT, V21, P438, DOI 10.4158/EP15693.CS
   Gerstein HC, 2017, DIABETES CARE, V40, P280, DOI 10.2337/dc16-1682
   Gomezrubio V., 2017, J STAT SOFTW, V77, P1, DOI [DOI 10.18637/JSS.V077.B02, 10.18637/jss.v077.b02]
   Gonzalez N, 2017, ONCOTARGET, V8, P18456, DOI 10.18632/oncotarget.14472
   Han J, 2015, ANAL CHIM ACTA, V854, P86, DOI 10.1016/j.aca.2014.11.015
   Husaini Y, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0233846
   Jakobsdottir G, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0080476
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Klil-Drori AJ, 2017, NAT REV CLIN ONCOL, V14, P85, DOI 10.1038/nrclinonc.2016.120
   Kyrgiou M, 2017, BMJ-BRIT MED J, V356, DOI 10.1136/bmj.j477
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Ma YA, 2018, BRIT J CANCER, V119, P1436, DOI 10.1038/s41416-018-0314-4
   McMurdie PJ, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0061217
   Mootha VK, 2003, NAT GENET, V34, P267, DOI 10.1038/ng1180
   Neuwirth Erich, 2014, CRAN
   Ocvirk Soeren, 2019, Curr Gastroenterol Rep, V21, P62, DOI 10.1007/s11894-019-0725-2
   Ohigashi S, 2013, DIGEST DIS SCI, V58, P1717, DOI 10.1007/s10620-012-2526-4
   Pernicova I, 2014, NAT REV ENDOCRINOL, V10, P143, DOI 10.1038/nrendo.2013.256
   Pollak M, 2013, J CLIN INVEST, V123, P3693, DOI 10.1172/JCI67232
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   R Core Team, 2013, R LANG ENV STAT COMP
   Segata N, 2011, GENOME BIOL, V12, DOI 10.1186/gb-2011-12-6-r60
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Subramanian A, 2005, P NATL ACAD SCI USA, V102, P15545, DOI 10.1073/pnas.0506580102
   Tibshirani R, 2002, P NATL ACAD SCI USA, V99, P6567, DOI 10.1073/pnas.082099299
   Topping DL, 2001, PHYSIOL REV, V81, P1031, DOI 10.1152/physrev.2001.81.3.1031
   Ulrich CM, 2018, NAT REV GASTRO HEPAT, V15, P683, DOI 10.1038/s41575-018-0053-2
   Vital M, 2017, MSYSTEMS, V2, DOI 10.1128/mSystems.00130-17
   Vital M, 2014, MBIO, V5, DOI 10.1128/mBio.00889-14
   Vogtmann E, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0155362
   Walter J, 2020, CELL, V180, P221, DOI 10.1016/j.cell.2019.12.025
   Wang J, 2016, NAT REV MICROBIOL, V14, P508, DOI 10.1038/nrmicro.2016.83
   Whelan FJ, 2017, MICROBIOME, V5, DOI 10.1186/s40168-017-0314-2
   Wickham H., 2017, TIDYVERSE
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Zhang CY, 2020, CELL METAB, V31, P148, DOI 10.1016/j.cmet.2019.10.013
NR 58
TC 7
Z9 7
U1 3
U2 5
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2212-8778
J9 MOL METAB
JI Mol. Metab.
PD JUL
PY 2022
VL 61
AR 101498
DI 10.1016/j.molmet.2022.101498
EA MAY 2022
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 1T2BK
UT WOS:000804540600008
PM 35452877
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Liu, ZY
   Liao, WD
   Zhang, ZH
   Sun, RP
   Luo, YF
   Chen, QF
   Li, X
   Lu, RL
   Ying, Y
AF Liu, Zhiyi
   Liao, Wangdi
   Zhang, Zihan
   Sun, Ruipu
   Luo, Yunfei
   Chen, Qiongfeng
   Li, Xin
   Lu, Ruiling
   Ying, Ying
TI Metformin Affects Gut Microbiota Composition and Diversity Associated
   with Amelioration of Dextran Sulfate Sodium-Induced Colitis in Mice
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE inflammatory bowel disease; metformin; gut microbiota; anti-inflammatory
   effect; biodiversity
ID AKKERMANSIA-MUCINIPHILA; DISEASE
AB Background: Inflammatory bowel disease (IBD) is an increasingly common and globally emergent immune-mediated disorder. The etiology of IBD is complex, involving multiple factors such as immune dysregulation, environmental factors, genetic mutations, and microbiota dysbiosis, exacerbated by a lack of effective clinical therapies. Recently, studies hypothesized that dysbiosis of intestinal flora might participate in the onset of IBD. Metformin is widely used to treat type 2 diabetes and has shown beneficial effects in mouse models of IBD, although its underlying mechanisms remain poorly understood. Accumulating studies found that metformin shows beneficial effects for diabetes by affecting microbiota composition. This study explores possible regulatory effects of metformin on intestinal microecology during treatment for IBD.
   Methods: Inflammation was induced using 3% Dextran Sulfate Sodium (DSS) solution to generate mice models of IBD. Metformin treatments were assayed by measuring body weights and colon lengths of mice and H&E staining to observe histological effects on colon tissue structures. Changes in bacterial community composition and diversity-related to IBD and metformin treatment were assessed by high-throughput metagenomic sequencing analysis.
   Results: Metformin administration significantly ameliorated body weight loss, inhibited colon shrinking, and contributed to preserving the integrity of colon histological structures. The gut microbiota profiles revealed that the biodiversity of intestinal flora lost during inflammation was restored under metformin treatment. Metformin administration was also associated with decreased pathogenic Escherichia shigella and increased abundance of Lactobacillus and Akkermansia.
   Conclusion: Metformin appears to induce anti-inflammatory effects, thus ameliorating colitis symptoms, concurrent with enrichment for beneficial taxa and restored microbial diversity, suggesting a viable strategy against IBD.
C1 [Liu, Zhiyi; Zhang, Zihan; Sun, Ruipu; Ying, Ying] Nanchang Univ, Jiangxi Inst Resp Dis, Affiliated Hosp 1, Nanchang, Jiangxi, Peoples R China.
   [Liu, Zhiyi; Zhang, Zihan; Sun, Ruipu] Nanchang Univ, Queen Mary Sch, Nanchang, Jiangxi, Peoples R China.
   [Liao, Wangdi; Li, Xin; Lu, Ruiling] Nanchang Univ, Dept Gastroenterol, Affiliated Hosp 1, Nanchang, Jiangxi, Peoples R China.
   [Luo, Yunfei; Chen, Qiongfeng; Ying, Ying] Nanchang Univ, Dept Pathophysiol, Sch Basic Med Sci, Nanchang, Jiangxi, Peoples R China.
   [Ying, Ying] Nanchang Univ, Dept Resp & Crit Care Med, Affiliated Hosp 1, Nanchang, Jiangxi, Peoples R China.
C3 Nanchang University; Nanchang University; Nanchang University; Nanchang
   University; Nanchang University
RP Ying, Y (通讯作者)，Nanchang Univ, Jiangxi Inst Resp Dis, Affiliated Hosp 1, Nanchang, Jiangxi, Peoples R China.; Ying, Y (通讯作者)，Nanchang Univ, Dept Pathophysiol, Sch Basic Med Sci, Nanchang, Jiangxi, Peoples R China.; Ying, Y (通讯作者)，Nanchang Univ, Dept Resp & Crit Care Med, Affiliated Hosp 1, Nanchang, Jiangxi, Peoples R China.
EM yingying@ncu.edu.cn
RI Sun, Ruipu/GYR-3422-2022
OI luo, yunfei/0000-0002-6838-5950
FU National Natural Science Foundation of China [81960110]; Nanchang
   University Students' Innovation and Entrepreneurship Training Program
   [2020CX299]
FX This study was supported by the National Natural Science Foundation of
   China (No. 81960110), Nanchang University Students' Innovation and
   Entrepreneurship Training Program (No. 2020CX299).
CR Bai AP, 2006, POSTGRAD MED J, V82, P376, DOI 10.1136/pgmj.2005.040899
   Bauer PV, 2018, CELL METAB, V27, P101, DOI 10.1016/j.cmet.2017.09.019
   Bian XY, 2019, FRONT MICROBIOL, V10, DOI 10.3389/fmicb.2019.02259
   Buldak L, 2016, N-S ARCH PHARMACOL, V389, P1103, DOI 10.1007/s00210-016-1277-8
   Canto E, 2019, J CROHNS COLITIS, V13, P92, DOI 10.1093/ecco-jcc/jjy138
   Chen YY, 2020, J PATHOL, V250, P170, DOI 10.1002/path.5358
   de Souza HSP, 2016, NAT REV GASTRO HEPAT, V13, P13, DOI [10.1038/nrgastro.2015.186, 10.1038/nrgastro.2016.186]
   Elbere I, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0204317
   Eppinga H, 2016, J CROHNS COLITIS, V10, P1067, DOI 10.1093/ecco-jcc/jjw070
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Guo XF, 2017, BMC GENOMICS, V18, DOI 10.1186/s12864-017-4195-3
   Huang KY, 2019, J AGR FOOD CHEM, V67, P11408, DOI 10.1021/acs.jafc.9b04411
   Kim J, 2014, J BIOL CHEM, V289, P23246, DOI 10.1074/jbc.M114.577908
   Kotloff KL, 2013, LANCET, V382, P209, DOI 10.1016/S0140-6736(13)60844-2
   Lee SY, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0135858
   Matsuoka K, 2015, SEMIN IMMUNOPATHOL, V37, P47, DOI 10.1007/s00281-014-0454-4
   Ni J, 2017, NAT REV GASTRO HEPAT, V14, P573, DOI 10.1038/nrgastro.2017.88
   Nishida A, 2018, CLIN J GASTROENTEROL, V11, P1, DOI 10.1007/s12328-017-0813-5
   Takaishi H, 2008, INT J MED MICROBIOL, V298, P463, DOI 10.1016/j.ijmm.2007.07.016
   Tseng CH, 2021, J CROHNS COLITIS, V15, P64, DOI 10.1093/ecco-jcc/jjaa136
   Viollet B, 2012, CLIN SCI, V122, P253, DOI 10.1042/CS20110386
   Wan P, 2019, FOOD RES INT, V126, DOI 10.1016/j.foodres.2019.108595
   Wlodarska M, 2015, CELL HOST MICROBE, V17, P577, DOI 10.1016/j.chom.2015.04.008
   Wu H, 2020, FRONT PHARMACOL, V10, DOI 10.3389/fphar.2019.01652
   Xue YS, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0168670
   Zarei-Kordshouli F, 2019, BMC INFECT DIS, V19, DOI 10.1186/s12879-018-3619-2
   Zhang W, 2019, BIOMED PHARMACOTHER, V118, DOI 10.1016/j.biopha.2019.109131
   Zhang X, 2015, SCI REP-UK, V5, DOI 10.1038/srep14405
NR 28
TC 15
Z9 15
U1 1
U2 10
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD MAY 21
PY 2021
VL 12
AR 640347
DI 10.3389/fphar.2021.640347
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA SP2WB
UT WOS:000659533700001
PM 34122067
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Vallianou, NG
   Stratigou, T
   Tsagarakis, S
AF Vallianou, Natalia G.
   Stratigou, Theodora
   Tsagarakis, Stylianos
TI Metformin and gut microbiota: their interactions and their impact on
   diabetes
SO HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
LA English
DT Review
DE Metformin; Microbiota; Microbiome; Metabolomics; Diabetes
ID GLUCOSE; INSULIN; EXPRESSION; METAGENOME
AB The ratio of human to bacterial cells in the human body (microbiota) is around 1:1. As a result of co-evolution of the host mucosal immune system and the microbiota, both have developed multiple mechanisms to maintain homeostasis. However, dissociations between the composition of the gut microbiota and the human host may play a crucial role in the development of type 2 diabetes. Metformin, the most frequently administered medication to treat patients with type 2 diabetes, has only recently been suggested to alter gut microbiota composition through the increase in mucin-degrading Akkermansia muciniphila, as well as several SCFA-producing (short-chain fatty acid) microbiota. The gut microbiota of participants on metformin has exerted alterations in gut metabolomics with increased ability to produce butyrate and propionate, substances involved in glucose homeostasis. Thus, metformin appears to affect the microbiome, and an individual's metformin tolerance or intolerance may be influenced by their microbiome. In this review, we will focus on the effects of metformin in gut microbiota among patients with T2DM.
C1 [Vallianou, Natalia G.; Stratigou, Theodora; Tsagarakis, Stylianos] Evangelismos Gen Hosp, Dept Endocrinol Diabet & Metab, 45-47 Ipsilantou Str, Athens, Greece.
C3 Evangelismos Hospital
RP Vallianou, NG (通讯作者)，Evangelismos Gen Hosp, Dept Endocrinol Diabet & Metab, 45-47 Ipsilantou Str, Athens, Greece.
EM natalia.vallianou@hotmail.com
OI vallianou, natalia/0000-0003-3874-5393
CR Asaka J, 2006, PHARM RES-DORDR, V23, P697, DOI 10.1007/s11095-006-9665-2
   Backhed F, 2005, SCIENCE, V307, P1915, DOI 10.1126/science.1104816
   Bailey CJ, 2008, DIABETOLOGIA, V51, P1552, DOI 10.1007/s00125-008-1053-5
   Barengolts E, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0194171
   BONORA E, 1984, CURR MED RES OPIN, V9, P47, DOI 10.1185/03007998409109558
   Brunkwall L, 2017, DIABETOLOGIA, V60, P943, DOI 10.1007/s00125-017-4278-3
   Burton Jeffrey H, 2015, J Diabetes Sci Technol, V9, P808, DOI 10.1177/1932296815577425
   Buse JB, 2016, DIABETES CARE, V39, P92, DOI 10.2337/dc15-1531
   Daviss B, 2005, SCIENTIST, V19, P25
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   DeFronzo RA, 2016, DIABETOLOGIA, V59, P1645, DOI 10.1007/s00125-016-3992-6
   Dresser MJ, 2002, PHARMACEUT RES, V19, P1244, DOI 10.1023/A:1019870831174
   Duca FA, 2015, NAT MED, V21, P506, DOI 10.1038/nm.3787
   Duong JK, 2013, DRUG SAFETY, V36, P733, DOI 10.1007/s40264-013-0038-6
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Gall WE, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0010883
   Gill SR, 2006, SCIENCE, V312, P1355, DOI 10.1126/science.1124234
   Gong L, 2012, PHARMACOGENET GENOM, V22, P820, DOI 10.1097/FPC.0b013e3283559b22
   Henry RR, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0203946
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kimura Naoko, 2005, Drug Metab Pharmacokinet, V20, P379, DOI 10.2133/dmpk.20.379
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Leabman MK, 2003, PHARMACOGENETICS, V13, P581, DOI 10.1097/00008571-200309000-00007
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Li Q, 2010, ACTA PHARMACOL SIN, V31, P184, DOI 10.1038/aps.2009.189
   Maideen NMP, 2017, ADV PHARM BULL, V7, P501, DOI 10.15171/apb.2017.062
   Mato EPM, 2018, MEDICINE, V97, DOI 10.1097/MD.0000000000011349
   McCreight LJ, 2016, DIABETOLOGIA, V59, P426, DOI 10.1007/s00125-015-3844-9
   Napolitano A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100778
   Pedersen HK, 2016, NATURE, V535, P376, DOI 10.1038/nature18646
   Perry RJ, 2016, NATURE, V534, P213, DOI 10.1038/nature18309
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Sekar S, 2011, J DIABETES COMPLICAT, V25, P187, DOI 10.1016/j.jdiacomp.2010.07.003
   Sender R, 2016, PLOS BIOL, V14, DOI 10.1371/journal.pbio.1002533
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Tilg H, 2014, GUT, V63, P1513, DOI 10.1136/gutjnl-2014-306928
   Urakami Y, 1999, FEBS LETT, V461, P339, DOI 10.1016/S0014-5793(99)01491-X
   Urakami Y, 2000, FEBS LETT, V473, P173, DOI 10.1016/S0014-5793(00)01525-8
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Zhang XY, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0071108
NR 40
TC 56
Z9 58
U1 2
U2 41
PU SPRINGER INTERNATIONAL PUBLISHING AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 1109-3099
EI 2520-8721
J9 HORM-INT J ENDOCRINO
JI Horm.-Int. J. Endocrinol. Metab.
PD JUN
PY 2019
VL 18
IS 2
BP 141
EP 144
DI 10.1007/s42000-019-00093-w
PG 4
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA IQ3BV
UT WOS:000480626500004
PM 30719628
DA 2023-06-08
ER

PT J
AU Szymczak-Pajor, I
   Wenclewska, S
   Sliwinska, A
AF Szymczak-Pajor, Izabela
   Wenclewska, Sylwia
   Sliwinska, Agnieszka
TI Metabolic Action of Metformin
SO PHARMACEUTICALS
LA English
DT Review
DE metformin; hepatic gluconeogenesis; glucose metabolism; lipid metabolism
ID ACTIVATED PROTEIN-KINASE; ORGANIC CATION TRANSPORTERS; MITOCHONDRIAL
   GLYCEROL-3-PHOSPHATE DEHYDROGENASE; GLUCAGON-LIKE PEPTIDE-1; BROWN
   ADIPOSE-TISSUE; GLUCOSE-PRODUCTION; HEPATIC GLUCONEOGENESIS; FATTY-ACID;
   SKELETAL-MUSCLE; GUT MICROBIOTA
AB Metformin, a cheap and safe biguanide derivative, due to its ability to influence metabolism, is widely used as a first-line drug for type 2 diabetes (T2DM) treatment. Therefore, the aim of this review was to present the updated biochemical and molecular effects exerted by the drug. It has been well explored that metformin suppresses hepatic glucose production in both AMPK-independent and AMPK-dependent manners. Substantial scientific evidence also revealed that its action is related to decreased secretion of lipids from intestinal epithelial cells, as well as strengthened oxidation of fatty acids in adipose tissue and muscles. It was recognized that metformin's supra-therapeutic doses suppress mitochondrial respiration in intestinal epithelial cells, whereas its therapeutic doses elevate cellular respiration in the liver. The drug is also suggested to improve systemic insulin sensitivity as a result of alteration in gut microbiota composition, maintenance of intestinal barrier integrity, and alleviation of low-grade inflammation.
C1 [Szymczak-Pajor, Izabela; Sliwinska, Agnieszka] Med Univ Lodz, Dept Nucle Acid Biochem, 251 Pomorska Str, PL-92213 Lodz, Poland.
   [Wenclewska, Sylwia] Med Univ Lodz, Dept Internal Med Diabetol & Clin Pharmacol, 251 Pomorska Str, PL-92213 Lodz, Poland.
C3 Medical University Lodz; Medical University Lodz
RP Szymczak-Pajor, I (通讯作者)，Med Univ Lodz, Dept Nucle Acid Biochem, 251 Pomorska Str, PL-92213 Lodz, Poland.
EM izabela.szymczak@umed.lodz.pl; sylwia.wenclewska@umed.lodz.pl;
   agnieszka.sliwinska@umed.lodz.pl
RI Sliwinska, Agnieszka/S-9813-2016
OI Sliwinska, Agnieszka/0000-0002-6864-0704; Szymczak-Pajor,
   Izabela/0000-0002-6545-579X
FU Medical University of Lodz [503/1-159-01/503-21-001]
FX This study and paper were supported by a grant from the Medical
   University of Lodz (No. 503/1-159-01/503-21-001).
CR Alshawi A, 2019, J BIOL CHEM, V294, P2839, DOI 10.1074/jbc.RA118.006670
   Amer Diabet Assoc, 2020, DIABETES CARE, V43, pS98, DOI 10.2337/dc20-S009
   Bailey CJ, 2008, DIABETOLOGIA, V51, P1552, DOI 10.1007/s00125-008-1053-5
   BAILEY CJ, 1994, BRIT J PHARMACOL, V112, P671, DOI 10.1111/j.1476-5381.1994.tb13128.x
   Barbera A, 2003, DIABETOLOGIA, V46, P1394, DOI 10.1007/s00125-003-1206-5
   Bridges HR, 2014, BIOCHEM J, V462, P475, DOI 10.1042/BJ20140620
   Calza G, 2018, FRONT PHARMACOL, V9, DOI 10.3389/fphar.2018.00141
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   Cao J, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-00163-w
   Cao J, 2014, J BIOL CHEM, V289, P20435, DOI 10.1074/jbc.M114.567271
   CARLING D, 1987, FEBS LETT, V223, P217, DOI 10.1016/0014-5793(87)80292-2
   CARLSON CA, 1973, J BIOL CHEM, V248, P378
   CEDERBAU.AI, 1973, ARCH BIOCHEM BIOPHYS, V158, P763, DOI 10.1016/0003-9861(73)90571-7
   CHAPPELL JB, 1963, J BIOL CHEM, V238, P410
   Chen EC, 2015, MOL PHARMACOL, V88, P75, DOI 10.1124/mol.114.096776
   Chen Y, 2009, PHARMACOGENOMICS J, V9, P127, DOI 10.1038/tpj.2008.19
   Choi MK, 2007, BIOPHARM DRUG DISPOS, V28, P501, DOI 10.1002/bdd.576
   Coll AP, 2020, NATURE, V578, P444, DOI 10.1038/s41586-019-1911-y
   Cusi K, 1996, J CLIN ENDOCR METAB, V81, P4059, DOI 10.1210/jc.81.11.4059
   DAVIDOFF F, 1968, J CLIN INVEST, V47, P2331, DOI 10.1172/JCI105918
   Day EA, 2019, NAT METAB, V1, P1202, DOI 10.1038/s42255-019-0146-4
   DEFRONZO RA, 1995, NEW ENGL J MED, V333, P541, DOI 10.1056/NEJM199508313330902
   Di Magno L, 2020, CELL REP, V30, P1735, DOI 10.1016/j.celrep.2020.01.024
   Duca FA, 2015, NAT MED, V21, P506, DOI 10.1038/nm.3787
   Dykens JA, 2008, TOXICOL APPL PHARM, V233, P203, DOI 10.1016/j.taap.2008.08.013
   Eamin EE, 2013, J NUTR, V143, P1872, DOI 10.3945/jn.113.179549
   El-Mir MY, 2000, J BIOL CHEM, V275, P223, DOI 10.1074/jbc.275.1.223
   EVANS PF, 1983, BIOCHEM PHARMACOL, V32, P3459, DOI 10.1016/0006-2952(83)90377-5
   Fernie AR, 2004, CURR OPIN PLANT BIOL, V7, P254, DOI 10.1016/j.pbi.2004.03.007
   Fischer M, 2010, DIABETES OBES METAB, V12, P356, DOI 10.1111/j.1463-1326.2009.01169.x
   Foretz M, 2019, NAT REV ENDOCRINOL, V15, P569, DOI 10.1038/s41574-019-0242-2
   Foretz M, 2010, J CLIN INVEST, V120, P2355, DOI 10.1172/JCI40671
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Fullerton MD, 2013, NAT MED, V19, P1649, DOI 10.1038/nm.3372
   GAN SC, 1992, ARCH INTERN MED, V152, P2333, DOI 10.1001/archinte.152.11.2333
   Geerling JJ, 2014, DIABETES, V63, P880, DOI 10.2337/db13-0194
   Gong DW, 1998, DNA CELL BIOL, V17, P301, DOI 10.1089/dna.1998.17.301
   Gong L, 2012, PHARMACOGENET GENOM, V22, P820, DOI 10.1097/FPC.0b013e3283559b22
   Gontier E, 2008, EUR J NUCL MED MOL I, V35, P95, DOI 10.1007/s00259-007-0563-6
   Gormsen LC, 2019, DIABETOLOGIA, V62, P1251, DOI 10.1007/s00125-019-4872-7
   Grisouard J, 2010, BIOCHEM PHARMACOL, V80, P1736, DOI 10.1016/j.bcp.2010.08.021
   Grosskopf I, 1997, DIABETES CARE, V20, P1598, DOI 10.2337/diacare.20.10.1598
   Guo ZJ, 2017, CELL CHEM BIOL, V24, P1259, DOI 10.1016/j.chembiol.2017.08.009
   Hardie DG, 2012, NAT REV MOL CELL BIO, V13, P251, DOI 10.1038/nrm3311
   HARDING JW, 1975, BIOCHEM J, V146, P223, DOI 10.1042/bj1460223
   Hattori Y, 2006, HYPERTENSION, V47, P1183, DOI 10.1161/01.HYP.0000221429.94591.72
   Hawley SA, 2002, DIABETES, V51, P2420, DOI 10.2337/diabetes.51.8.2420
   He L, 2015, CELL METAB, V21, P159, DOI 10.1016/j.cmet.2015.01.003
   HOLLUNGER G, 1955, Acta Pharmacol Toxicol (Copenh), V11, P1
   Hundal RS, 2000, DIABETES, V49, P2063, DOI 10.2337/diabetes.49.12.2063
   Hunter RW, 2018, NAT MED, V24, P1395, DOI 10.1038/s41591-018-0159-7
   Inzucchi SE, 1998, NEW ENGL J MED, V338, P867, DOI 10.1056/NEJM199803263381303
   Iversen AB, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-10010-z
   Jakobsen S, 2016, J NUCL MED, V57, P615, DOI 10.2967/jnumed.115.169292
   JEPPESEN J, 1994, DIABETES CARE, V17, P1093, DOI 10.2337/diacare.17.10.1093
   Jin HE, 2009, PHARM RES-DORDR, V26, P549, DOI 10.1007/s11095-008-9770-5
   Jornayvaz FR, 2010, ESSAYS BIOCHEM, V47, P69, DOI [10.1042/BSE0470069, 10.1042/bse0470069]
   Karise I, 2019, BIOMED PHARMACOTHER, V111, P1156, DOI 10.1016/j.biopha.2019.01.021
   Kim EK, 2016, MEDIAT INFLAMM, V2016, DOI 10.1155/2016/5813030
   Kim MH, 2014, J ENDOCRINOL, V220, P117, DOI 10.1530/JOE-13-0381
   Kimura Naoko, 2005, Drug Metab Pharmacokinet, V20, P379, DOI 10.2133/dmpk.20.379
   King P, 1999, BRIT J CLIN PHARMACO, V48, P643, DOI 10.1046/j.1365-2125.1999.00092.x
   Koffert JP, 2017, DIABETES RES CLIN PR, V131, P208, DOI 10.1016/j.diabres.2017.07.015
   Konopka AR, 2016, CELL REP, V15, P1394, DOI 10.1016/j.celrep.2016.04.024
   Koo SH, 2005, NATURE, V437, P1109, DOI 10.1038/nature03967
   Koza RA, 1996, ARCH BIOCHEM BIOPHYS, V336, P97, DOI 10.1006/abbi.1996.0536
   Kristensen JM, 2014, AM J PHYSIOL-ENDOC M, V306, pE1099, DOI 10.1152/ajpendo.00417.2013
   LANOUE KF, 1971, METABOLISM, V20, P119, DOI 10.1016/0026-0495(71)90087-4
   Larsen S, 2012, DIABETOLOGIA, V55, P443, DOI 10.1007/s00125-011-2340-0
   Laugel V., 1993, GENEREVIEWS
   Leclerc I, 2001, DIABETES, V50, P1515, DOI 10.2337/diabetes.50.7.1515
   Lee A, 1998, OBES RES, V6, P47, DOI 10.1002/j.1550-8528.1998.tb00314.x
   Lee JO, 2012, J BIOL CHEM, V287, P44121, DOI 10.1074/jbc.M112.361386
   Lewis AJM, 2016, DIABETES, V65, P3544, DOI 10.2337/db16-0804
   Li WJ, 2019, AGING DIS, V10, P949, DOI 10.14336/AD.2019.0120
   Li XY, 2019, G3-GENES GENOM GENET, V9, P513, DOI 10.1534/g3.118.200803
   LIETZ T, 1995, ARCH BIOCHEM BIOPHYS, V321, P501, DOI 10.1006/abbi.1995.1423
   Lietz T, 1997, ACTA BIOCHIM POL, V44, P323
   MACDONALD MJ, 1981, J BIOL CHEM, V256, P8287
   Madiraju AK, 2018, NAT MED, V24, P1384, DOI 10.1038/s41591-018-0125-4
   Madiraju AK, 2014, NATURE, V510, P542, DOI 10.1038/nature13270
   Mannucci E, 2004, DIABETES NUTR METAB, V17, P336
   Martin-Montalvo A, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms3192
   Masuda S, 2006, J AM SOC NEPHROL, V17, P2127, DOI 10.1681/ASN.2006030205
   McCreight LJ, 2016, DIABETOLOGIA, V59, P426, DOI 10.1007/s00125-015-3844-9
   MCGARRY JD, 1978, J BIOL CHEM, V253, P4128
   Meng SM, 2015, J BIOL CHEM, V290, P3793, DOI 10.1074/jbc.M114.604421
   Migoya EM, 2010, CLIN PHARMACOL THER, V88, P801, DOI 10.1038/clpt.2010.184
   Mihaylova MM, 2011, CELL, V145, P607, DOI 10.1016/j.cell.2011.03.043
   Miller RA, 2013, NATURE, V494, P256, DOI 10.1038/nature11808
   Muller J, 2005, BIOCHEM PHARMACOL, V70, P1851, DOI 10.1016/j.bcp.2005.09.011
   Musi N, 2002, DIABETES, V51, P2074, DOI 10.2337/diabetes.51.7.2074
   Napolitano A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100778
   Natali A, 2019, DIABETES OBES METAB, V21, P412, DOI 10.1111/dom.13519
   NURJHAN N, 1992, J CLIN INVEST, V89, P169, DOI 10.1172/JCI115558
   Nygaard EB, 2012, EXP DIABETES RES, DOI 10.1155/2012/465282
   Oakhill JS, 2012, TRENDS ENDOCRIN MET, V23, P125, DOI 10.1016/j.tem.2011.12.006
   Okamura H, 2007, CELL BIOL INT, V31, P119, DOI 10.1016/j.cellbi.2006.09.014
   Owen MR, 2000, BIOCHEM J, V348, P607, DOI 10.1042/0264-6021:3480607
   Petersen KF, 2004, NEW ENGL J MED, V350, P664, DOI 10.1056/NEJMoa031314
   Polianskyte-Prause Z, 2019, FASEB J, V33, P2858, DOI 10.1096/fj.201800529RR
   PUHAKAINEN I, 1992, J CLIN ENDOCR METAB, V75, P789, DOI 10.1210/jc.75.3.789
   Qi HY, 2018, DIABETOLOGIA, V61, P445, DOI 10.1007/s00125-017-4445-6
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Radziuk J, 1997, DIABETES, V46, P1406, DOI 10.2337/diabetes.46.9.1406
   Rajasurya V, 2019, CUREUS, V11, DOI 10.7759/cureus.4739
   Rebrin K, 1996, J CLIN INVEST, V98, P741, DOI 10.1172/JCI118846
   Repiscak P, 2014, BIOCHEMISTRY-US, V53, P787, DOI 10.1021/bi401444n
   Ridaura VK, 2013, SCIENCE, V341, P1079, DOI 10.1126/science.1241214
   Sato T, 2016, METABOLISM, V65, P1646, DOI 10.1016/j.metabol.2016.08.005
   Sato T, 2008, BIOCHEM PHARMACOL, V76, P894, DOI 10.1016/j.bcp.2008.07.005
   Savage DB, 2006, J CLIN INVEST, V116, P817, DOI 10.1172/JCI27300
   Scarpello JHB, 1998, DIABETIC MED, V15, P651, DOI 10.1002/(SICI)1096-9136(199808)15:8<651::AID-DIA628>3.0.CO;2-A
   Scheen AJ, 2013, DIABETES METAB, V39, P179, DOI 10.1016/j.diabet.2013.02.006
   Scheen AJ, 1996, CLIN PHARMACOKINET, V30, P359, DOI 10.2165/00003088-199630050-00003
   Schommers P, 2017, MOL METAB, V6, P737, DOI 10.1016/j.molmet.2017.05.002
   Shaw RJ, 2005, SCIENCE, V310, P1642, DOI 10.1126/science.1120781
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Shingaki T, 2015, PHARM RES-DORDR, V32, P2538, DOI 10.1007/s11095-015-1642-1
   Shirasaka Y, 2022, J PHARM SCI-US, V111, P1531, DOI 10.1016/j.xphs.2022.01.008
   Shu Y, 2008, CLIN PHARMACOL THER, V83, P273, DOI 10.1038/sj.clpt.6100275
   Soeters PB, 2021, CLIN NUTR, V40, P2988, DOI 10.1016/j.clnu.2021.02.012
   Song SM, 2001, AM J PHYSIOL-ENDOC M, V281, pE275, DOI 10.1152/ajpendo.2001.281.2.E275
   Soty M, 2015, MOL METAB, V4, P106, DOI 10.1016/j.molmet.2014.12.009
   Takashima M, 2010, DIABETES, V59, P1608, DOI 10.2337/db09-1679
   Thakur S, 2018, CLIN CANCER RES, V24, P4030, DOI 10.1158/1078-0432.CCR-17-3167
   Toyama EQ, 2016, SCIENCE, V351, P275, DOI 10.1126/science.aab4138
   TUCKER GT, 1981, BRIT J CLIN PHARMACO, V12, P235
   Vasamsetti SB, 2015, DIABETES, V64, P2028, DOI 10.2337/db14-1225
   Victor VM, 2015, EUR J ENDOCRINOL, V173, P683, DOI 10.1530/EJE-15-0572
   Virtanen KA, 2003, DIABETES, V52, P283, DOI 10.2337/diabetes.52.2.283
   Wang C, 2014, CLIN LAB, V60, P887, DOI 10.7754/Clin.Lab.2013.130531
   Wang DS, 2002, J PHARMACOL EXP THER, V302, P510, DOI 10.1124/jpet.102.034140
   Wang Y, 2019, CELL REP, V29, P1511, DOI 10.1016/j.celrep.2019.09.070
   WILCOCK C, 1991, J PHARM PHARMACOL, V43, P442, DOI 10.1111/j.2042-7158.1991.tb03507.x
   WILCOCK C, 1994, XENOBIOTICA, V24, P49, DOI 10.3109/00498259409043220
   Winiarska K, 1998, ACTA BIOCHIM POL, V45, P825, DOI 10.18388/abp.1998_4278
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Wu TZ, 2014, DIABETES RES CLIN PR, V106, pE3, DOI 10.1016/j.diabres.2014.08.004
   Xie JJ, 2020, CANCER RES, V80, P2150, DOI 10.1158/0008-5472.CAN-19-2852
   Yaribeygi H, 2019, J CELL PHYSIOL, V234, P8152, DOI 10.1002/jcp.27603
   Youle RJ, 2012, SCIENCE, V337, P1062, DOI 10.1126/science.1219855
   Zhang CS, 2016, CELL METAB, V24, P521, DOI 10.1016/j.cmet.2016.09.003
   Zhang Q, 2020, DIABET METAB SYND OB, V13, P5003, DOI 10.2147/DMSO.S286430
   Zheng Y, 2019, HEPATOLOGY, V70, P84, DOI 10.1002/hep.30507
   Zhou GC, 2001, J CLIN INVEST, V108, P1167, DOI 10.1172/JCI200113505
   Zhou MY, 2007, DRUG METAB DISPOS, V35, P1956, DOI 10.1124/dmd.107.015495
NR 147
TC 8
Z9 8
U1 6
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1424-8247
J9 PHARMACEUTICALS-BASE
JI Pharmaceuticals
PD JUL
PY 2022
VL 15
IS 7
AR 810
DI 10.3390/ph15070810
PG 20
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 3G9ZU
UT WOS:000831705100001
PM 35890109
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Luo, C
   Wang, X
   Huang, HX
   Mao, XY
   Zhou, HH
   Liu, ZQ
AF Luo, Chao
   Wang, Xu
   Huang, Hanxue
   Mao, Xiaoyuan
   Zhou, Honghao
   Liu, Zhaoqian
TI Effect of Metformin on Antipsychotic-Induced Metabolic Dysfunction: The
   Potential Role of Gut-Brain Axis
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE antipsychotic; metabolic dysfunction; metformin; gut-brain axis; gut
   microbiota; hypothalamus
ID INDUCED WEIGHT-GAIN; GENOME-WIDE ASSOCIATION; DOUBLE-BLIND;
   INSULIN-RESISTANCE; 1ST-EPISODE SCHIZOPHRENIA; ATYPICAL ANTIPSYCHOTICS;
   PEPTIDE-1 SECRETION; CHRONIC OLANZAPINE; PROLACTIN LEVELS; BODY-WEIGHT
AB Antipsychotics are the first-line medications prescribed for patients with schizophrenia or other mental disorders. Cumulative evidence has revealed that metabolic dysfunctions frequently occur in patients receiving antipsychotics, especially second-generation antipsychotics, and these effects may decrease patient compliance and increase health costs. Metformin is an effective pharmaceutical adjuvant for ameliorating antipsychotic-induced metabolic dysfunction (AIMD) in clinical practice. However, the mechanism of the effects of metformin on AIMD remains unclear. The gut-brain axis is a bidirectional communication system between the gastrointestinal tract and the central nervous system and has been associated with many pathological and physiological conditions, such as those related to metabolism. Antipsychotics interact with and have affinity for dopamine receptors and other receptors in the brain, and treatment with these antipsychotics has been shown to influence gut microbiota metabolism and composition, as observed in both animal and human studies. Metformin exerts an antidiabetic effect that is correlated with activation of AMP-kinase in the hypothalamus, and metformin also influences gut flora. Therefore, the gut-brain axis may play a role in the effect of metformin on AIMD. Since no direct evidence is available, this perspective may provide a direction for further research.
C1 [Luo, Chao; Wang, Xu; Huang, Hanxue; Mao, Xiaoyuan; Zhou, Honghao; Liu, Zhaoqian] Cent South Univ, Xiangya Hosp, Dept Clin Pharmacol, Changsha, Hunan, Peoples R China.
   [Luo, Chao; Wang, Xu; Huang, Hanxue; Mao, Xiaoyuan; Zhou, Honghao; Liu, Zhaoqian] Cent South Univ, Hunan Key Lab Pharmacogenet, Inst Clin Pharmacol, Changsha, Hunan, Peoples R China.
   [Luo, Chao] Cent South Univ, Sch Life Sci, Changsha, Hunan, Peoples R China.
   [Zhou, Honghao; Liu, Zhaoqian] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Hunan, Peoples R China.
C3 Central South University; Central South University; Central South
   University; Central South University
RP Liu, ZQ (通讯作者)，Cent South Univ, Xiangya Hosp, Dept Clin Pharmacol, Changsha, Hunan, Peoples R China.; Liu, ZQ (通讯作者)，Cent South Univ, Hunan Key Lab Pharmacogenet, Inst Clin Pharmacol, Changsha, Hunan, Peoples R China.; Liu, ZQ (通讯作者)，Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Hunan, Peoples R China.
EM liuzhaoqian63@126.com
RI lll, zzzz/HJY-6145-2023; Luo, Chao/GQH-1910-2022
OI Luo, Chao/0000-0002-7007-1440
FU National Key Research and Development Program of China [2016YFC1306900];
   National Natural Science Foundation of China [81573508]; Open Foundation
   of Innovative Platform in Colleges and University of Hunan Province of
   China [[2015]54]; Clinical Research Fund of Peking University
   Unamed-Central South University Xiangya Hospital [xywm2015I16]
FX This work was supported by the National Key Research and Development
   Program of China (2016YFC1306900), National Natural Science Foundation
   of China (81573508), Open Foundation of Innovative Platform in Colleges
   and University of Hunan Province of China ([2015]54), and Clinical
   Research Fund of Peking University Unamed-Central South University
   Xiangya Hospital (xywm2015I16).
CR Adeneye AA, 2011, INDIAN J EXP BIOL, V49, P332
   Aubert G, 2011, METABOLISM, V60, P327, DOI 10.1016/j.metabol.2010.02.007
   Bahr SM, 2015, TRANSL PSYCHIAT, V5, DOI 10.1038/tp.2015.135
   Bahr SM, 2015, EBIOMEDICINE, V2, P1725, DOI 10.1016/j.ebiom.2015.10.018
   Baptista T, 2006, CAN J PSYCHIAT, V51, P192, DOI 10.1177/070674370605100310
   Bauer PV, 2018, CELL METAB, V27, P101, DOI 10.1016/j.cmet.2017.09.019
   Bauer PV, 2016, CELL MOL LIFE SCI, V73, P737, DOI 10.1007/s00018-015-2083-z
   Billa E, 2009, GYNECOL ENDOCRINOL, V25, P427, DOI 10.1080/09513590902770172
   Borg MJ, 2019, DIABETES OBES METAB, V21, P640, DOI 10.1111/dom.13567
   Boyda HN, 2012, J PSYCHIATR NEUROSCI, V37, P407, DOI 10.1503/jpn.110140
   Brandl EJ, 2016, PHARMACOGENOMICS J, V16, P352, DOI 10.1038/tpj.2015.59
   Bronden A, 2017, J CLIN ENDOCR METAB, V102, P4153, DOI 10.1210/jc.2017-01091
   Cabreiro F, 2013, CELL, V153, P228, DOI 10.1016/j.cell.2013.02.035
   Cubeddu LX, 2000, N-S ARCH PHARMACOL, V361, P85, DOI 10.1007/s002109900152
   Cussotto S, 2019, PSYCHOPHARMACOLOGY, V236, P1671, DOI 10.1007/s00213-018-5006-5
   Davey KJ, 2013, TRANSL PSYCHIAT, V3, DOI 10.1038/tp.2013.83
   Davey KJ, 2012, PSYCHOPHARMACOLOGY, V221, P155, DOI 10.1007/s00213-011-2555-2
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Delahanty LM, 2012, DIABETES CARE, V35, P363, DOI 10.2337/dc11-1328
   Deng C, 2012, J PSYCHOPHARMACOL, V26, P1271, DOI 10.1177/0269881112449396
   Duca FA, 2015, NAT MED, V21, P506, DOI 10.1038/nm.3787
   Elbere I, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0204317
   Evers SS, 2017, J PSYCHOPHARMACOL, V31, P1437, DOI 10.1177/0269881117724749
   Flowers SA, 2017, PHARMACOTHERAPY, V37, P261, DOI 10.1002/phar.1890
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Frost G, 2014, NAT COMMUN, V5, DOI 10.1038/ncomms4611
   Goetz RL, 2019, SCHIZOPHR RES, V206, P21, DOI 10.1016/j.schres.2018.11.036
   Gregoor JG, 2009, J CLIN PSYCHOPHARM, V29, P21, DOI 10.1097/JCP.0b013e31819359be
   Han M, 2008, PSYCHONEUROENDOCRINO, V33, P569, DOI 10.1016/j.psyneuen.2008.01.018
   Hu YS, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0093310
   Kao ACC, 2018, TRANSL PSYCHIAT, V8, DOI 10.1038/s41398-018-0116-8
   Klein DJ, 2006, AM J PSYCHIAT, V163, P2072, DOI 10.1176/appi.ajp.163.12.2072
   Krysiak R, 2018, EXP CLIN ENDOCR DIAB, V126, P342, DOI 10.1055/s-0043-122224
   Krysiak R, 2016, EUR J INTERN MED, V30, P94, DOI 10.1016/j.ejim.2016.01.015
   Krysiak R, 2015, J CLIN PHARMACOL, V55, P45, DOI 10.1002/jcph.373
   Lee CK, 2012, DIABETES METAB J, V36, P293, DOI 10.4093/dmj.2012.36.4.293
   Lee H, 2018, GERONTOLOGIST, V58, P159, DOI 10.1093/geront/gnx050
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Lian JM, 2016, PHARMACOL RES, V106, P51, DOI 10.1016/j.phrs.2016.02.011
   Lian JM, 2015, PHARMACOL RES, V95-96, P20, DOI 10.1016/j.phrs.2015.03.004
   Lian JM, 2014, PSYCHONEUROENDOCRINO, V48, P77, DOI 10.1016/j.psyneuen.2014.06.010
   Lord CC, 2017, J CLIN INVEST, V127, P3408, DOI 10.1172/JCI93362
   Luo C, 2019, NEUROSCI BULL, V35, P561, DOI 10.1007/s12264-018-0323-6
   Lv WS, 2012, BRAIN RES, V1444, P11, DOI 10.1016/j.brainres.2012.01.028
   Ma W, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.01336
   Malin SK, 2014, CURR OPIN ENDOCRINOL, V21, P323, DOI 10.1097/MED.0000000000000095
   Manu P, 2015, ACTA PSYCHIAT SCAND, V132, P97, DOI 10.1111/acps.12445
   Maruthur NM, 2016, ANN INTERN MED, V164, P740, DOI 10.7326/M15-2650
   Mayer EA, 2015, J CLIN INVEST, V125, P926, DOI 10.1172/JCI76304
   McCreight LJ, 2016, DIABETOLOGIA, V59, P426, DOI 10.1007/s00125-015-3844-9
   Michel K, 2005, GASTROENTEROLOGY, V128, P1317, DOI 10.1053/j.gastro.2005.02.005
   Morgan AP, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0115225
   Morrison JA, 2002, AM J PSYCHIAT, V159, P655, DOI 10.1176/appi.ajp.159.4.655
   Nguyen TT, 2018, J PSYCHIATR RES, V99, P50, DOI 10.1016/j.jpsychires.2018.01.013
   Petra AI, 2015, CLIN THER, V37, P984, DOI 10.1016/j.clinthera.2015.04.002
   Potvin Stephane, 2015, Can J Psychiatry, V60, pS26
   Puangpetch A, 2018, J PHARM PHARMACOL, V70, P536, DOI 10.1111/jphp.12892
   Remington GJ, 2015, J ENDOCRINOL, V227, P71, DOI 10.1530/JOE-15-0074
   Reynolds GP, 2017, J PSYCHOPHARMACOL, V31, P1430, DOI 10.1177/0269881117722987
   Reynolds GP, 2002, LANCET, V359, P2086, DOI 10.1016/S0140-6736(02)08913-4
   Rojczyk E, 2015, NEUROPEPTIDES, V51, P31, DOI 10.1016/j.npep.2015.04.001
   Samara MT, 2016, JAMA PSYCHIAT, V73, P199, DOI 10.1001/jamapsychiatry.2015.2955
   Sandhu KV, 2017, TRANSL RES, V179, P223, DOI 10.1016/j.trsl.2016.10.002
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Skonieczna-Zydecka K, 2019, PSYCHOPHARMACOLOGY, V236, P1491, DOI 10.1007/s00213-018-5102-6
   Stroup TS, 2018, WORLD PSYCHIATRY, V17, P341, DOI 10.1002/wps.20567
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Tang XM, 2016, J ENDOCRINOL, V230, P227, DOI 10.1530/JOE-16-0142
   Tolhurst G, 2012, DIABETES, V61, P364, DOI 10.2337/db11-1019
   van Bennekom MWHL, 2013, J PSYCHOPHARMACOL, V27, P327, DOI 10.1177/0269881113477709
   van Os J, 2009, LANCET, V374, P635, DOI [10.1016/S0140-6736(09)60995-8, 10.1016/S0140-6736(15)01121-6]
   Vazquez-Borrego MC, 2018, CELL PHYSIOL BIOCHEM, V49, P1444, DOI 10.1159/000493448
   Werner FM, 2014, EXPERT OPIN DRUG SAF, V13, P1031, DOI 10.1517/14740338.2014.935761
   Westfall S, 2017, CELL MOL LIFE SCI, V74, P3769, DOI 10.1007/s00018-017-2550-9
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Wu RR, 2016, MOL PSYCHIATR, V21, P1537, DOI 10.1038/mp.2015.221
   Wu RR, 2008, AM J PSYCHIAT, V165, P352, DOI 10.1176/appi.ajp.2007.07010079
   Wu RR, 2008, JAMA-J AM MED ASSOC, V299, P185, DOI 10.1001/jama.2007.56-b
   Wu RR, 2007, J CLIN PSYCHOPHARM, V27, P374, DOI 10.1097/JCP.0b013e3180cac8db
   Wu RR, 2012, AM J PSYCHIAT, V169, P813, DOI 10.1176/appi.ajp.2012.11091432
   Wu Renrong, 2011, Zhong Nan Da Xue Xue Bao Yi Xue Ban, V36, P720, DOI 10.3969/j.issn.1672-7347.2011.08.003
   Yang YF, 2012, BEHAV BRAIN FUNCT, V8, DOI 10.1186/1744-9081-8-11
   Yu H, 2016, SCHIZOPHRENIA BULL, V42, P814, DOI 10.1093/schbul/sbv179
   Yuan XX, 2018, SCHIZOPHR RES, V201, P299, DOI 10.1016/j.schres.2018.05.017
   Zhang JP, 2016, SCHIZOPHRENIA BULL, V42, P1418, DOI 10.1093/schbul/sbw058
   Zhang XQ, 2015, SCI REP-UK, V5, DOI 10.1038/srep10737
   Zhou ZY, 2016, ACTA PHARMACOL SIN, V37, P1063, DOI 10.1038/aps.2016.21
NR 87
TC 14
Z9 16
U1 0
U2 10
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD APR 9
PY 2019
VL 10
AR 371
DI 10.3389/fphar.2019.00371
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pharmacology & Pharmacy
GA HS5TP
UT WOS:000463934300001
PM 31024322
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Jauvain, M
   Courtois, S
   Lehours, P
   Bessede, E
AF Jauvain, Marine
   Courtois, Sarah
   Lehours, Philippe
   Bessede, Emilie
TI Metformin Modifies the Gut Microbiota of Mice Infected with Helicobacter
   pylori
SO PHARMACEUTICALS
LA English
DT Article
DE Helicobacter pylori; metformin; microbiota; PICRUSt
ID NITRIC-OXIDE SYNTHASE; CANCER; ASSOCIATION; GLUCOSE; RISK; EPIDEMIOLOGY;
   METABOLITES; EXPRESSION; INTESTINE; COMMUNITY
AB Metformin is widely prescribed to treat type 2 diabetes. Diabetes patients treated with metformin have a decreased risk of cancers, including gastric cancer. Among the factors influencing digestive carcinogenesis, gut microbiota interactions have been intensively studied. Metformin exhibits direct antimicrobial activity toward Helicobacter pylori, which plays a crucial role in gastric carcinogenesis. Mice were infected with H. pylori and treated for 12 days with either metformin or phosphate-buffered saline (PBS) as a control. At the end of the treatment period, the mice were euthanized and cecal and intestinal contents and stool were collected. The gut microbiota of the three different digestive sites (stool, cecal, and intestinal contents) were characterized through 16S RNA gene sequencing. In mice infected with H. pylori, metformin significantly decreased alpha diversity indices and led to significant variation in the relative abundance of some bacterial taxa including Clostridium and Lactobacillus, which were directly inhibited by metformin in vitro. PICRUSt analysis suggested that metformin modifies functional pathway expression, including a decrease in nitrate reducing bacteria in the intestine. Metformin significantly changed the composition and predicted function of the gut microbiota of mice infected with H. pylori; these modifications could be implicated in digestive cancer prevention.
C1 [Jauvain, Marine; Courtois, Sarah; Lehours, Philippe; Bessede, Emilie] Univ Bordeaux, BaRITOn, UMR 1053 Bordeaux Res Translat Oncol, INSERM, F-33000 Bordeaux, France.
   [Lehours, Philippe; Bessede, Emilie] Univ Hosp Bordeaux, French Natl Reference Ctr Campylobacters & Helico, F-33000 Bordeaux, France.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   UDICE-French Research Universities; Universite de Bordeaux; CHU
   Bordeaux; UDICE-French Research Universities; Universite de Bordeaux
RP Bessede, E (通讯作者)，Univ Bordeaux, BaRITOn, UMR 1053 Bordeaux Res Translat Oncol, INSERM, F-33000 Bordeaux, France.; Bessede, E (通讯作者)，Univ Hosp Bordeaux, French Natl Reference Ctr Campylobacters & Helico, F-33000 Bordeaux, France.
EM marine.jauvain@u-bordeaux.fr; sarah.courtois@u-bordeaux.fr;
   philippe.lehours@u-bordeaux.fr; emilie.bessede@u-bordeaux.fr
RI Bessede, Emilie/HKF-3098-2023
OI Jauvain, Marine/0000-0002-2488-6892; Courtois,
   Sarah/0000-0001-8572-2499; Lehours, Philippe/0000-0001-6704-8699
CR Al Kattar S, 2020, CANCERS, V12, DOI 10.3390/cancers12071857
   Ambs S, 1998, P NATL ACAD SCI USA, V95, P8823, DOI 10.1073/pnas.95.15.8823
   Bahmani S, 2019, TURK J GASTROENTEROL, V30, P835, DOI 10.5152/tjg.2019.18451
   BAILEY CJ, 1994, BRIT J PHARMACOL, V112, P671, DOI 10.1111/j.1476-5381.1994.tb13128.x
   Barzilai N, 2016, CELL METAB, V23, P1060, DOI 10.1016/j.cmet.2016.05.011
   Belcheva A, 2014, CELL, V158, P288, DOI 10.1016/j.cell.2014.04.051
   Bray Freddie, 2018, CA Cancer J Clin, V68, P394, DOI 10.3322/caac.21492
   Brown LM, 2000, EPIDEMIOL REV, V22, P283, DOI 10.1093/oxfordjournals.epirev.a018040
   Cho YH, 2014, INTEST RES, V12, P139, DOI 10.5217/ir.2014.12.2.139
   Coker OO, 2018, GUT, V67, P1024, DOI 10.1136/gutjnl-2017-314281
   CORREA P, 1992, CANCER RES, V52, P6735
   Courtois S, 2018, FUTURE MICROBIOL, V13, P1575, DOI 10.2217/fmb-2018-0184
   Cremonesi E, 2018, GUT, V67, P1984, DOI 10.1136/gutjnl-2016-313498
   Derrien M, 2017, MICROB PATHOGENESIS, V106, P171, DOI 10.1016/j.micpath.2016.02.005
   Eslami M, 2019, J CELL PHYSIOL, V234, P17127, DOI 10.1002/jcp.28473
   Evans JMM, 2005, BMJ-BRIT MED J, V330, P1304, DOI 10.1136/bmj.38415.708634.F7
   Feng CW, 2002, BMC CANCER, V2, DOI 10.1186/1471-2407-2-8
   Ferreira RM, 2018, GUT, V67, P226, DOI 10.1136/gutjnl-2017-314205
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Gao JJ, 2018, FRONT CELL INFECT MI, V8, DOI 10.3389/fcimb.2018.00202
   Gonzalez CA, 2012, ANN ONCOL, V23, P1320, DOI 10.1093/annonc/mdr384
   Jandhyala SM, 2015, WORLD J GASTROENTERO, V21, P8787, DOI 10.3748/wjg.v21.i29.8787
   Kaakoush NO, 2016, FEMS MICROBIOL ECOL, V92, DOI 10.1093/femsec/fiw161
   Langille MGI, 2013, NAT BIOTECHNOL, V31, P814, DOI 10.1038/nbt.2676
   LEACH SA, 1987, CARCINOGENESIS, V8, P1907, DOI 10.1093/carcin/8.12.1907
   Lee A, 1997, GASTROENTEROLOGY, V112, P1386, DOI 10.1016/S0016-5085(97)70155-0
   Lee H, 2018, GUT MICROBES, V9, P155, DOI 10.1080/19490976.2017.1405209
   Lehours P, 2004, INFECT IMMUN, V72, P880, DOI 10.1128/IAI.72.2.880-888.2004
   Lofgren JL, 2011, GASTROENTEROLOGY, V140, P210, DOI 10.1053/j.gastro.2010.09.048
   Ma W, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.01336
   Maldonado-Contreras A, 2011, ISME J, V5, P574, DOI 10.1038/ismej.2010.149
   McCreight LJ, 2016, DIABETOLOGIA, V59, P426, DOI 10.1007/s00125-015-3844-9
   Megraud F, 2015, CLIN MICROBIOL INFEC, V21, P984, DOI 10.1016/j.cmi.2015.06.004
   Morales DR, 2015, ANNU REV MED, V66, P17, DOI 10.1146/annurev-med-062613-093128
   Morita Y, 2020, DIABETES CARE, V43, P1796, DOI 10.2337/dc20-0093
   Nair AB., 2016, BASIC CLIN PHARMACOL, V7, DOI DOI 10.4103/0976-0105.177703
   Nathan DM, 2009, DIABETES CARE, V32, P193, DOI 10.2337/dc08-9025
   Org E, 2016, GUT MICROBES, V7, P313, DOI 10.1080/19490976.2016.1203502
   Parks DH, 2010, BIOINFORMATICS, V26, P715, DOI 10.1093/bioinformatics/btq041
   Rajagopala SV, 2017, CANCER PREV RES, V10, P226, DOI 10.1158/1940-6207.CAPR-16-0249
   Rooks MG, 2016, NAT REV IMMUNOL, V16, P341, DOI 10.1038/nri.2016.42
   Salani B, 2014, ENDOCR-RELAT CANCER, V21, pR461, DOI 10.1530/ERC-14-0284
   Santos-Marcos JA, 2018, MATURITAS, V116, P43, DOI 10.1016/j.maturitas.2018.07.008
   Schwabe RF, 2013, NAT REV CANCER, V13, P800, DOI 10.1038/nrc3610
   Segata N, 2011, GENOME BIOL, V12, DOI 10.1186/gb-2011-12-6-r60
   WILCOCK C, 1994, XENOBIOTICA, V24, P49, DOI 10.3109/00498259409043220
   Wong JMW, 2006, J CLIN GASTROENTEROL, V40, P235, DOI 10.1097/00004836-200603000-00015
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Yi FH, 2008, ENDOCRINOLOGY, V149, P2341, DOI 10.1210/en.2007-1142
   Zhang HH, 2016, CANCER CHEMOTH PHARM, V78, P13, DOI 10.1007/s00280-016-3037-3
   Zhou GC, 2001, J CLIN INVEST, V108, P1167, DOI 10.1172/JCI200113505
   Zhou XL, 2017, ONCOTARGET, V8, P55622, DOI 10.18632/oncotarget.16973
NR 52
TC 2
Z9 3
U1 0
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1424-8247
J9 PHARMACEUTICALS-BASE
JI Pharmaceuticals
PD APR
PY 2021
VL 14
IS 4
AR 329
DI 10.3390/ph14040329
PG 15
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA RR9TQ
UT WOS:000643431700001
PM 33916777
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Nakajima, H
   Takewaki, F
   Hashimoto, Y
   Kajiyama, S
   Majima, S
   Okada, H
   Senmaru, T
   Ushigome, E
   Nakanishi, N
   Hamaguchi, M
   Yamazaki, M
   Tanaka, Y
   Oikawa, Y
   Nakajima, S
   Ohno, H
   Fukui, M
AF Nakajima, Hanako
   Takewaki, Fumie
   Hashimoto, Yoshitaka
   Kajiyama, Shizuo
   Majima, Saori
   Okada, Hiroshi
   Senmaru, Takafumi
   Ushigome, Emi
   Nakanishi, Naoko
   Hamaguchi, Masahide
   Yamazaki, Masahiro
   Tanaka, Yoshiki
   Oikawa, Yousuke
   Nakajima, Shunji
   Ohno, Hiroshi
   Fukui, Michiaki
TI The Effects of Metformin on the Gut Microbiota of Patients with Type 2
   Diabetes: A Two-Center, Quasi-Experimental Study
SO LIFE-BASEL
LA English
DT Article
DE metformin; diabetes mellites; dysbiosis; gastrointestinal symptoms
ID GASTROINTESTINAL SYMPTOMS; RATING-SCALE; JAPANESE; VERSION;
   HYPERGLYCEMIA; ASSOCIATION; METAGENOME; INHIBITOR; DYSBIOSIS; IMMUNITY
AB Metformin is reported to affect human gut microbiota; however, the nature of this association in Japanese patients with type 2 diabetes mellitus (T2DM) is unknown. We enrolled 31 patients with T2DM who took metformin for the first time in this study. We compared them before and after four weeks of taking metformin. Fecal samples were collected and 16S rDNA sequences were performed to identify the gut microbiota. Blood samples and Gastrointestinal Symptom Rating Scale (GSRS) questionnaire results, denoting gastro-intestinal symptoms, were also collected. In the whole-group analysis, no significant differences were found at the phylum level. In a subgroup of 21 patients that excluding those using medications affecting gut microbiota, there was a significant decrease of the phylum Firmicutes (p= 0.042) and of the ratio of the Firmicutes and Bacteroidetes abundances (p= 0.04) after taking metformin. Changes in abdominal pain (r= -0.56,p= 0.008) and regurgitation (r= -0.53,p= 0.01) were associated withParabacteroides. Despite there being no direct association with abdominal symptoms, our study revealed that the composition of gut microbiota in Japanese individuals with T2DM partially changed after starting metformin.
C1 [Nakajima, Hanako; Takewaki, Fumie; Hashimoto, Yoshitaka; Kajiyama, Shizuo; Majima, Saori; Okada, Hiroshi; Senmaru, Takafumi; Ushigome, Emi; Nakanishi, Naoko; Hamaguchi, Masahide; Yamazaki, Masahiro; Fukui, Michiaki] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Endocrinol & Metab, Kyoto 6028566, Japan.
   [Kajiyama, Shizuo] Kajiyama Clin, Kyoto 6008898, Japan.
   [Okada, Hiroshi] Matsushita Mem Hosp, Dept Internal Med, Moriguchi, Osaka 5708540, Japan.
   [Tanaka, Yoshiki; Oikawa, Yousuke; Nakajima, Shunji; Ohno, Hiroshi] Biofermin Pharmaceut Co Ltd, R&D Ctr, Kobe, Hyogo 6500021, Japan.
C3 Kyoto Prefectural University of Medicine
RP Hashimoto, Y (通讯作者)，Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Endocrinol & Metab, Kyoto 6028566, Japan.
EM tabahana@koto.kpu-m.ac.jp; fumi12112000@yahoo.co.jp;
   y-hashi@koto.kpu-m.ac.jp; kajiyama-clinic@dream.ocn.ne.jp;
   saori-m@koto.kpu-m.ac.jp; conti@koto.kpu-m.ac.jp;
   semmarut@koto.kpu-m.ac.jp; emis@koto.kpu-m.ac.jp;
   naoko-n@koto.kpu-m.ac.jp; mhama@koto.kpu-m.ac.jp;
   masahiro@koto.kpu-m.ac.jp; tanaka_yoshiki@biofermin.co.jp;
   oikawa_yousuke@biofermin.co.jp; nakajima_shunji@biofermin.co.jp;
   ohno_hiroshi@biofermin.co.jp; michiaki@koto.kpu-m.ac.jp
RI Hashimoto, Yoshitaka/AAH-8503-2020
OI Hashimoto, Yoshitaka/0000-0002-8794-0550; Fukui,
   Michiaki/0000-0003-0903-1797; Hamaguchi, Masahide/0000-0002-8651-4445;
   Okada, Hiroshi/0000-0002-1707-970X; Nakajima,
   Hanako/0000-0002-3209-1790; Nakajima, Shunji/0000-0002-9864-6111;
   Nakanishi, Naoko/0000-0003-0092-2593
FU Biofermin Pharma Co., Ltd, Kobe, Japan
FX This work was supported by the Biofermin Pharma Co., Ltd, Kobe, Japan.
CR Abbas HA, 2017, AFR HEALTH SCI, V17, P808, DOI 10.4314/ahs.v17i3.24
   Adachi K, 2019, J CLIN BIOCHEM NUTR, V64, P231, DOI 10.3164/jcbn.18-101
   BAILEY CJ, 1992, DIABETES CARE, V15, P755, DOI 10.2337/diacare.15.6.755
   BENJAMINI Y, 1995, J R STAT SOC B, V57, P289, DOI 10.1111/j.2517-6161.1995.tb02031.x
   Bryrup T, 2019, DIABETOLOGIA, V62, P1024, DOI 10.1007/s00125-019-4848-7
   Caporaso JG, 2010, NAT METHODS, V7, P335, DOI 10.1038/nmeth.f.303
   Chang CJ, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms8489
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   DIMENAS E, 1993, SCAND J GASTROENTERO, V28, P681, DOI 10.3109/00365529309098272
   Duca FA, 2015, NAT MED, V21, P506, DOI 10.1038/nm.3787
   Fadrosh DW, 2014, MICROBIOME, V2, DOI 10.1186/2049-2618-2-6
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Fujishiro M, 2017, WORLD J GASTROENTERO, V23, P6694, DOI 10.3748/wjg.v23.i36.6694
   Gao CX, 2015, MBIO, V6, DOI 10.1128/mBio.01358-15
   Garber AJ, 1997, AM J MED, V103, P491, DOI 10.1016/S0002-9343(97)00254-4
   Gomi A, 2018, J DAIRY SCI, V101, P4830, DOI 10.3168/jds.2017-13803
   Hashimoto Y, 2020, J DIABETES INVEST, V11, P1623, DOI 10.1111/jdi.13293
   Kadota K, 2008, ALGORITHM MOL BIOL, V3, DOI 10.1186/1748-7188-3-8
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kelly TN, 2016, CIRC RES, V119, P956, DOI 10.1161/CIRCRESAHA.116.309219
   Kistler BM, 2018, J RENAL NUTR, V28, P129, DOI 10.1053/j.jrn.2017.08.006
   Kverka M, 2011, CLIN EXP IMMUNOL, V163, P250, DOI 10.1111/j.1365-2249.2010.04286.x
   Kyriachenko Y, 2019, WORLD J DIABETES, V10, P154, DOI 10.4239/wjd.v10.i3.154
   Liao XY, 2019, EBIOMEDICINE, V44, P665, DOI 10.1016/j.ebiom.2019.03.057
   Liu YH, 2019, AM J CLIN NUTR, V110, P701, DOI 10.1093/ajcn/nqz139
   Lopetuso LR, 2017, DIGEST DIS, V36, P56, DOI 10.1159/000477205
   Lozupone C, 2005, APPL ENVIRON MICROB, V71, P8228, DOI 10.1128/AEM.71.12.8228-8235.2005
   Matsuki T, 2004, APPL ENVIRON MICROB, V70, P167, DOI 10.1128/AEM.70.1.167-173.2004
   Matsuo S, 2009, AM J KIDNEY DIS, V53, P982, DOI 10.1053/j.ajkd.2008.12.034
   McCreight LJ, 2016, DIABETOLOGIA, V59, P426, DOI 10.1007/s00125-015-3844-9
   Naito Y, 2018, DIGESTION, V97, P195, DOI 10.1159/000481813
   Nasrin F., 2014, IJPDA, V3, P220
   Nathan DM, 2009, DIABETES CARE, V32, P193, DOI 10.2337/dc08-9025
   Nishijima S, 2016, DNA RES, V23, P125, DOI 10.1093/dnares/dsw002
   Olivares M, 2018, DIABETOLOGIA, V61, P1838, DOI 10.1007/s00125-018-4647-6
   Patkee WRA, 2016, J CELL MOL MED, V20, P758, DOI 10.1111/jcmm.12784
   Pernicova I, 2014, NAT REV ENDOCRINOL, V10, P143, DOI 10.1038/nrendo.2013.256
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Sato J, 2014, DIABETES CARE, V37, P2343, DOI 10.2337/dc13-2817
   Segata N, 2011, GENOME BIOL, V12, DOI 10.1186/gb-2011-12-6-r60
   Shirasawa Y, 2010, J DAIRY SCI, V93, P4526, DOI 10.3168/jds.2010-3274
   SOUZA Gabriela Santos, 2016, Arq. Gastroenterol., V53, P146, DOI 10.1590/S0004-28032016000300005
   SVEDLUND J, 1988, DIGEST DIS SCI, V33, P129, DOI 10.1007/BF01535722
   Turan N, 2017, GASTROENTEROL NURS, V40, P47, DOI 10.1097/SGA.0000000000000177
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Watts PC, 2006, NATURE, V444, P1021, DOI 10.1038/4441021a
   World Health Organization, 2016, GLOBAL REPORT DIABET
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Xiao Y, 2020, VIRULENCE, V11, P39, DOI 10.1080/21505594.2019.1706305
   Zhang FH, 2019, ENDOCRINE, V66, P485, DOI 10.1007/s12020-019-02041-5
   Zhuang XJ, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.01600
NR 51
TC 16
Z9 16
U1 0
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2075-1729
J9 LIFE-BASEL
JI Life-Basel
PD SEP
PY 2020
VL 10
IS 9
AR 195
DI 10.3390/life10090195
PG 15
WC Biology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Microbiology
GA OD9NJ
UT WOS:000580170700001
PM 32932871
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Ouyang, J
   Isnard, S
   Lin, J
   Fombuena, B
   Marette, A
   Routy, B
   Chen, YK
   Routy, JP
AF Ouyang, Jing
   Isnard, Stephane
   Lin, John
   Fombuena, Brandon
   Marette, Andre
   Routy, Bertrand
   Chen, Yaokai
   Routy, Jean-Pierre
TI Metformin effect on gut microbiota: insights for HIV-related
   inflammation
SO AIDS RESEARCH AND THERAPY
LA English
DT Review
DE Metformin; Microbiota; Gut permeability; Inflammation; HIV
ID CHAIN FATTY-ACIDS; AKKERMANSIA-MUCINIPHILA; INTESTINAL MICROBIOTA;
   INSULIN SENSITIVITY; KYNURENINE PATHWAY; DIABETES-MELLITUS; IMMUNE
   ACTIVATION; INFECTED PATIENTS; METABOLISM; IMPROVEMENT
AB The gut microbiota is emerging as a prominent player in maintaining health through several metabolic and immune pathways. Dysregulation of gut microbiota composition, also known as dysbiosis, is involved in the clinical outcome of diabetes, inflammatory bowel diseases, cancer, aging and HIV infection. Gut dysbiosis and inflammation persist in people living with HIV (PLWH) despite receiving antiretroviral therapy, further contributing to non-AIDS comorbidities. Metformin, a widely used antidiabetic agent, has been found to benefit microbiota composition, promote gut barrier integrity and reduce inflammation in human and animal models of diabetes. Inspired by the effect of metformin on diabetes-related gut dysbiosis, we herein critically review the relevance of metformin to control inflammation in PLWH. Metformin may improve gut microbiota composition, in turn reducing inflammation and risk of non-AIDS comorbidities. This review will pave the way towards innovative strategies to counteract dysregulated microbiota and improve the lives of PLWH.
C1 [Ouyang, Jing; Chen, Yaokai] Chongqing Publ Hlth Med Ctr, Baoyu Rd 109, Chongqing, Peoples R China.
   [Ouyang, Jing; Isnard, Stephane; Lin, John; Fombuena, Brandon; Routy, Jean-Pierre] McGill Univ Hlth Ctr, Res Inst, Infect Dis & Immun Global Hlth Program, 1001 Blvd Decarie, Montreal, PQ, Canada.
   [Ouyang, Jing; Isnard, Stephane; Lin, John; Fombuena, Brandon; Routy, Jean-Pierre] McGill Univ Hlth Ctr, Chron Viral Illness Serv, 1001 Blvd Decarie, Montreal, PQ, Canada.
   [Fombuena, Brandon] McGill Univ, Dept Microbiol & Immunol, 845 Sherbrooke St West, Montreal, PQ, Canada.
   [Marette, Andre] Laval Univ, Cardiol Axis Quebec Heart & Lung Inst, Dept Med, Fac Med, 2325 Rue Univ, Laval, PQ, Canada.
   [Marette, Andre] Laval Univ, Inst Nutr & Funct Foods, 2325 Rue Univ, Laval, PQ, Canada.
   [Routy, Bertrand] Univ Montreal CRCHUM, Res Ctr, 900 St Denis St, Montreal, PQ, Canada.
   [Routy, Bertrand] Univ Montreal Healthcare Ctr CHUM, Hematol Oncol Div, Dept Med, 1051 Rue Sanguinet, Montreal, PQ, Canada.
   [Routy, Jean-Pierre] McGill Univ Hlth Ctr, Div Hematol, 1001 Blvd Decarie, Montreal, PQ, Canada.
C3 McGill University; McGill University; McGill University; Laval
   University; Quebec Heart & Lung Institute; Laval University; Universite
   de Montreal; McGill University
RP Chen, YK (通讯作者)，Chongqing Publ Hlth Med Ctr, Baoyu Rd 109, Chongqing, Peoples R China.; Routy, JP (通讯作者)，McGill Univ Hlth Ctr, Res Inst, Infect Dis & Immun Global Hlth Program, 1001 Blvd Decarie, Montreal, PQ, Canada.
EM yaokaichen@hotmail.com; jean-pierre.routy@mcgill.ca
RI Marette, Andre/E-9342-2013
OI Lin, John/0000-0002-2596-969X; Marette, Andre/0000-0003-3950-5973
FU Fonds de la Recherche Quebec-Sante (FRQ-S): Reseau SIDA/Maladies
   infectieuses and Therapie cellulaire; Canadian Institutes of Health
   Research (CIHR) [HOP 103230, PTJ 166049]; Vaccines & Immunotherapies
   Core of the CIHR Canadian HIV Trials Network (CTN) [CTN 257, CTN PT027];
   Canadian Foundation for AIDS Research (CANFAR) [02-512]; CIHR
   [HB2-164064]; Chinese National Science and Technology Major Project
   [2018ZX10302104]; CIHR Foundation Grant
FX Our work was funded by the Fonds de la Recherche Quebec-Sante (FRQ-S):
   Reseau SIDA/Maladies infectieuses and Therapie cellulaire; the Canadian
   Institutes of Health Research (CIHR; Grants HOP 103230 and PTJ 166049);
   the Vaccines & Immunotherapies Core of the CIHR Canadian HIV Trials
   Network (CTN; Grant CTN 257 and CTN PT027); the Canadian Foundation for
   AIDS Research (CANFAR; Grant 02-512); CIHR-funded Canadian HIV Cure
   Enterprise (CanCURE) Team Grant HB2-164064; and the Chinese National
   Science and Technology Major Project (No. 2018ZX10302104). Andre Marette
   holds a CIHR/Pfizer research Chair in the pathogenesis of insulin
   resistance and cardiovascular complications and is supported by a CIHR
   Foundation Grant.
CR Adachi K, 2019, J CLIN BIOCHEM NUTR, V64, P231, DOI 10.3164/jcbn.18-101
   Anhe FF, 2019, GUT, V68, P453, DOI 10.1136/gutjnl-2017-315565
   Araki K, 2009, NATURE, V460, P108, DOI 10.1038/nature08155
   Arrieta O, 2019, JAMA ONCOL, V5, DOI 10.1001/jamaoncol.2019.2553
   Bailey CJ, 2008, DIABETOLOGIA, V51, P1552, DOI 10.1007/s00125-008-1053-5
   Bhaskaran N, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.01995
   Brenchley JM, 2008, MUCOSAL IMMUNOL, V1, P23, DOI 10.1038/mi.2007.1
   Brenchley JM, 2006, NAT MED, V12, P1365, DOI 10.1038/nm1511
   Bryrup T, 2019, DIABETOLOGIA, V62, P1024, DOI 10.1007/s00125-019-4848-7
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Cani PD, 2018, GUT, V67, P1716, DOI 10.1136/gutjnl-2018-316723
   Chen J, 2019, CLIN INFECT DIS, V68, P1274, DOI 10.1093/cid/ciy676
   Choi Jeonghyun, 2018, J Lifestyle Med, V8, P1, DOI 10.15280/jlm.2018.8.1.1
   Crakes KR, 2019, P NATL ACAD SCI USA, V116, P24819, DOI 10.1073/pnas.1908977116
   D'Angelo C, 2017, NUTRIENTS, V9, DOI 10.3390/nu9060615
   Dao MC, 2016, GUT, V65, P426, DOI 10.1136/gutjnl-2014-308778
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Depommier C, 2019, NAT MED, V25, P1096, DOI 10.1038/s41591-019-0495-2
   Dillon SM, 2017, AIDS, V31, P510, DOI 10.1097/QAD.0000000000001366
   Driscoll SD, 2004, AIDS, V18, P465, DOI 10.1097/00002030-200402200-00013
   Duan W, 2019, AM J TRANSL RES, V11, P2393
   Elbere I, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0204317
   Estes JD, 2010, PLOS PATHOG, V6, DOI 10.1371/journal.ppat.1001052
   Estrada V, 2018, EBIOMEDICINE, V38, P17, DOI 10.1016/j.ebiom.2018.11.019
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Fitch K, 2012, AIDS, V26, P587, DOI 10.1097/QAD.0b013e32834f33cc
   Foretz M, 2019, NAT REV ENDOCRINOL, V15, P569, DOI 10.1038/s41574-019-0242-2
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Gallant JE, 2017, J INFECT DIS, V216, pS624, DOI 10.1093/infdis/jix238
   Glavan TW, 2015, J MED PRIMATOL, V44, P241, DOI 10.1111/jmp.12187
   Gonzalez-Hernandez LA, 2019, BMC INFECT DIS, V19, DOI 10.1186/s12879-019-3867-9
   Gurung M, 2020, EBIOMEDICINE, V51, DOI 10.1016/j.ebiom.2019.11.051
   Hadigan C, 2000, JAMA-J AM MED ASSOC, V284, P472, DOI 10.1001/jama.284.4.472
   Haissman JM, 2017, BMC INFECT DIS, V17, DOI 10.1186/s12879-017-2547-x
   Haissman JM, 2016, JAIDS-J ACQ IMM DEF, V71, P130, DOI 10.1097/QAI.0000000000000843
   Hoel H, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-25168-3
   Hsu DC, 2016, DRUGS, V76, P533, DOI 10.1007/s40265-016-0546-7
   Hughes CA, 2001, ANN PHARMACOTHER, V35, P877
   Iglay K, 2016, CURR MED RES OPIN, V32, P1243, DOI 10.1185/03007995.2016.1168291
   Jenabian MA, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0078146
   Jin Q, 2014, BRAIN BEHAV IMMUN, V40, P131, DOI 10.1016/j.bbi.2014.03.003
   Kalender A, 2010, CELL METAB, V11, P390, DOI 10.1016/j.cmet.2010.03.014
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kehrmann J, 2019, J INFECT DIS, V219, P497, DOI 10.1093/infdis/jiy524
   Klatt NR, 2013, J CLIN INVEST, V123, P903, DOI 10.1172/JCI66227
   Klil-Drori AJ, 2017, NAT REV CLIN ONCOL, V14, P85, DOI 10.1038/nrclinonc.2016.120
   Koh SJ, 2014, J GASTROEN HEPATOL, V29, P502, DOI 10.1111/jgh.12435
   Kootte RS, 2017, CELL METAB, V26, P611, DOI 10.1016/j.cmet.2017.09.008
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Lee SY, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0135858
   Li F, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0216948
   Liang HY, 2013, PLOS ONE, V8, DOI [10.1371/journal.pone.0063983, 10.1371/journal.pone.0074121]
   Mardinoglu A, 2016, CELL METAB, V23, P10, DOI 10.1016/j.cmet.2015.12.012
   Martin-Montalvo A, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms3192
   Mehandru S, 2005, J ALLERGY CLIN IMMUN, V116, P419, DOI 10.1016/j.jaci.2005.05.040
   Mehraj V, 2020, CLIN INFECT DIS, V70, P232, DOI 10.1093/cid/ciz212
   Meng JJ, 2020, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.02999
   Moon JY, 2018, EBIOMEDICINE, V37, P392, DOI 10.1016/j.ebiom.2018.10.037
   Moyo D, 2014, DIABETES RES CLIN PR, V103, pE34, DOI 10.1016/j.diabres.2013.12.042
   Mulligan K, 2007, AIDS, V21, P47, DOI 10.1097/QAD.0b013e328011220e
   Muzik O, 2017, BIOCHEM BIOPH RES CO, V488, P29, DOI 10.1016/j.bbrc.2017.04.155
   Ortiz-Brizuela E, 2015, REV INVEST CLIN, V67, P273
   Pandiyan P, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.00426
   Pollak M, 2017, DIABETOLOGIA, V60, P1662, DOI 10.1007/s00125-017-4352-x
   Polyzos KA, 2015, HAMOSTASEOLOGIE, V35, P128, DOI 10.5482/HAMO-14-10-0052
   Pryor R, 2019, CELL, V178, P1299, DOI 10.1016/j.cell.2019.08.003
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Ramendra R, 2020, CLIN INFECT DIS, V71, P1438, DOI 10.1093/cid/ciz1001
   Reunanen J, 2015, APPL ENVIRON MICROB, V81, P3655, DOI 10.1128/AEM.04050-14
   Rocafort M, 2019, MICROBIOME, V7, DOI 10.1186/s40168-019-0687-5
   Rosario D, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.00775
   Roumie CL, 2019, JAMA-J AM MED ASSOC, V322, P1167, DOI 10.1001/jama.2019.13206
   Roumie CL, 2014, JAMA-J AM MED ASSOC, V311, P2288, DOI 10.1001/jama.2014.4312
   Routy B, 2018, SCIENCE, V359, P91, DOI 10.1126/science.aan3706
   Routy JP, 2019, BMJ OPEN, V9, DOI 10.1136/bmjopen-2018-028444
   Routy JP, 2015, AIDS REV, V17, P96
   Saad MJA, 2016, PHYSIOLOGY, V31, P283, DOI 10.1152/physiol.00041.2015
   Shikuma CM, 2020, AIDS RES HUM RETROV, V36, P303, DOI [10.1089/aid.2019.0078, 10.1089/AID.2019.0078]
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   SUM CF, 1992, DIABETIC MED, V9, P61, DOI 10.1111/j.1464-5491.1992.tb01716.x
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Tamboli CP, 2004, GUT, V53, P1, DOI 10.1136/gut.53.1.1
   Tan J, 2014, ADV IMMUNOL, V121, P91, DOI 10.1016/B978-0-12-800100-4.00003-9
   Tang WHW, 2013, NEW ENGL J MED, V368, P1575, DOI 10.1056/NEJMoa1109400
   Tedelind S, 2007, WORLD J GASTROENTERO, V13, P2826, DOI 10.3748/wjg.v13.i20.2826
   Vazquez-Castellanos JF, 2018, ISME J, V12, P1964, DOI 10.1038/s41396-018-0151-8
   Victor VM, 2015, ATHEROSCLEROSIS, V242, P167, DOI 10.1016/j.atherosclerosis.2015.07.017
   Vinolo MAR, 2011, NUTRIENTS, V3, P858, DOI 10.3390/nu3100858
   Vrieze A, 2012, GASTROENTEROLOGY, V143, P913, DOI 10.1053/j.gastro.2012.06.031
   Vujkovic-Cvijin I, 2019, CURR HIV-AIDS REP, V16, P204, DOI 10.1007/s11904-019-00441-w
   Vujkovic-Cvijin I, 2013, SCI TRANSL MED, V5, DOI 10.1126/scitranslmed.3006438
   Wang GS, 2019, J INTENSIVE CARE MED, V34, P863, DOI 10.1177/0885066618793385
   Wang HB, 2012, DIGEST DIS SCI, V57, P3126, DOI 10.1007/s10620-012-2259-4
   Worth L, 2003, CLIN INFECT DIS, V37, P315, DOI 10.1086/375850
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Xue YS, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0168670
   Zicari S, 2019, VIRUSES-BASEL, V11, DOI 10.3390/v11030200
NR 98
TC 32
Z9 32
U1 2
U2 19
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1742-6405
J9 AIDS RES THER
JI Aids Res. Ther.
PD MAR 10
PY 2020
VL 17
IS 1
AR 10
DI 10.1186/s12981-020-00267-2
PG 9
WC Infectious Diseases
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases
GA KW3TD
UT WOS:000521088500001
PM 32156291
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Ryan, PM
   Patterson, E
   Carafa, I
   Mandal, R
   Wishart, DS
   Dinan, TG
   Cryan, JF
   Tuohy, KM
   Stanton, C
   Ross, RP
AF Ryan, Paul M.
   Patterson, Elaine
   Carafa, Ilaria
   Mandal, Rupasri
   Wishart, David S.
   Dinan, Timothy G.
   Cryan, John F.
   Tuohy, Kieran M.
   Stanton, Catherine
   Ross, R. Paul
TI Metformin and Dipeptidyl Peptidase-4 Inhibitor Differentially Modulate
   the Intestinal Microbiota and Plasma Metabolome of Metabolically
   Dysfunctional Mice
SO CANADIAN JOURNAL OF DIABETES
LA English
DT Article
DE diabetes; DPP-4; metformin; microbiota; PKF-275-055
ID HUMAN GUT MICROBIOME; GLUCOSE; OBESE; IMPACT; BUTYRATE; WEIGHT; TOOL
AB Objectives: Recent evidence indicates that gut microbiota is altered considerably by a variety of commonly prescribed medications. This study assessed the impact of 2 antidiabetic therapeutics on gut microbiota and markers of cardiometabolic disease in metabolically dysfunctional mice.
   Methods: C57BL/6 mice were fed a high-fat diet for 24 weeks while receiving 1 of 2 antidiabetic therapeutics-metformin or dipeptidyl peptidase-4 (DPP-4) inhibitor, PKF-275-055-for the final 12 weeks. Mice were assessed for weight gain, glucose and cholesterol metabolism, and adiposity. In addition, cecal microbiota was analyzed by 16S compositional sequencing, and plasma metabolome was analyzed by liquid chromatography with tandem mass spectrometry.
   Results: Both therapeutics had similar metabolic effects, attenuating mesenteric adiposity and improving cholesterol metabolism and insulin sensitivity. However, multivariate analyses of microbiota and metabolomics data revealed clear divergence of the therapeutic groups. Although both metformin and PKF-275-055 mice displayed significantly decreased Firmicutes/Bacteroidetes ratios, only metformin harboured metabolic health-associated Akkermansia, Parabacteroides and Christensenella. Paradoxically, metformin also reduced a diversity, a metric frequently associated with host metabolic fitness. PKF-275-055 mice displayed elevated levels of butyrate-producing Ruminococcus and acetogen Dorea, with reduced levels of certain plasma sphingomyelin, phosphatidylcholine and lysophosphatidylcholine entities. In turn, metformin reduced levels of acylcarnitines, a functional group associated with systemic metabolic dysfunction. Finally, several associations were identified between metabolites and altered taxa.
   Conclusions: This study represents the first direct comparison of the microbiota-modifying effects of metformin and a DPP-4 inhibitor, and proposes several putative microbial targets both in terms of novel therapeutic development and adverse effect prevention. (C) 2019 Canadian Diabetes Association.
C1 [Ryan, Paul M.] Univ Coll Cork, Sch Med, Cty Cork, Ireland.
   [Ryan, Paul M.; Patterson, Elaine; Stanton, Catherine] Teagasc Food Res Ctr, Moorepk, Fermoy, Cork, Ireland.
   [Ryan, Paul M.; Patterson, Elaine; Dinan, Timothy G.; Cryan, John F.; Stanton, Catherine; Ross, R. Paul] Univ Coll Cork, APC Microbiome Ireland, Biosci Bldg,Coll Rd, Cork, Cty Cork, Ireland.
   [Carafa, Ilaria; Tuohy, Kieran M.] Fdn Edmund Mach, Ist Agrario, San Michele All Adige, Italy.
   [Mandal, Rupasri; Wishart, David S.] Univ Alberta, Dept Biol Sci, Edmonton, AB, Canada.
   [Wishart, David S.] Univ Alberta, Dept Comp Sci, Edmonton, AB, Canada.
   [Wishart, David S.] Natl Inst Nanotechnol, Edmonton, AB, Canada.
   [Dinan, Timothy G.] Univ Coll Cork, Dept Psychiat, Cty Cork, Ireland.
   [Cryan, John F.] Univ Coll Cork, Dept Neurosci, Cty Cork, Ireland.
C3 University College Cork; Teagasc; University College Cork; Fondazione
   Edmund Mach; University of Alberta; University of Alberta; National
   Research Council Canada; University College Cork; University College
   Cork
RP Ross, RP (通讯作者)，Univ Coll Cork, APC Microbiome Ireland, Biosci Bldg,Coll Rd, Cork, Cty Cork, Ireland.
EM p.ross@ucc.ie
RI Stanton, Catherine/A-9549-2015; Cryan, John F./A-6950-2013; Dinan,
   Timothy/ABA-8284-2020; Ryan, Paul MacDaragh/ABG-5352-2020; Tuohy, Kieran
   M/G-9142-2011; Wishart, David Scott/ABI-3181-2020; Ross,
   Paul/A-7584-2015
OI Stanton, Catherine/0000-0002-6724-7011; Cryan, John
   F./0000-0001-5887-2723; Ryan, Paul MacDaragh/0000-0001-7251-6725; Tuohy,
   Kieran M/0000-0001-6882-7192; Ross, Paul/0000-0003-4876-8839; Carafa,
   Ilaria/0000-0002-3662-9535
FU Teagasc Walsh Fellowship; Ireland Canada University Foundation Dobbin
   Scholarship; Teagasc Walsh Fellow Short-term Overseas Training Award;
   APC Microbiome Ireland - Science Foundation Ireland [SFI/12/RC/2273]
FX P.M.R. was in receipt of a Teagasc Walsh Fellowship and travel support
   for work carried out in The Metabolomics Innovation Centre, which was
   provided by the Ireland Canada University Foundation Dobbin Scholarship
   and the Teagasc Walsh Fellow Short-term Overseas Training Award. This
   work is supported by APC Microbiome Ireland, a research centre funded by
   Science Foundation Ireland (grant number SFI/12/RC/2273).
CR Akarte AS, 2012, BIOCHEM PHARMACOL, V83, P241, DOI 10.1016/j.bcp.2011.10.003
   Al-Makdissy N, 2001, FEBS LETT, V493, P75, DOI 10.1016/S0014-5793(01)02278-5
   ANDERSON JW, 1984, P SOC EXP BIOL MED, V177, P372
   [Anonymous], OPEN BIOINFORMATICS
   [Anonymous], TYP 2 DIAB ADULTS MA
   Baker GC, 2003, J MICROBIOL METH, V55, P541, DOI 10.1016/j.mimet.2003.08.009
   Bokulich NA, 2013, NAT METHODS, V10, P57, DOI [10.1038/nmeth.2276, 10.1038/NMETH.2276]
   Canani RB, 2011, WORLD J GASTROENTERO, V17, P1519, DOI [10.3748/wjg.v17.i12. 1519, 10.3748/wjg.v17.i12.1519]
   Cao KAL, 2011, BMC BIOINFORMATICS, V12, DOI 10.1186/1471-2105-12-253
   Caporaso JG, 2010, NAT METHODS, V7, P335, DOI 10.1038/nmeth.f.303
   Caporaso JG, 2010, BIOINFORMATICS, V26, P266, DOI 10.1093/bioinformatics/btp636
   Claesson MJ, 2010, NUCLEIC ACIDS RES, V38, DOI 10.1093/nar/gkq873
   CLARKE BF, 1968, LANCET, V1, P123
   Danaei G, 2011, LANCET, V378, P31, DOI 10.1016/S0140-6736(11)60679-X
   David LA, 2014, NATURE, V505, P559, DOI 10.1038/nature12820
   Degner NR, 2018, CLIN INFECT DIS, V66, P198, DOI 10.1093/cid/cix819
   Dujic T, 2015, DIABETES, V64, P1786, DOI 10.2337/db14-1388
   Edgar RC, 2010, BIOINFORMATICS, V26, P2460, DOI 10.1093/bioinformatics/btq461
   Enright EF, 2018, PHARMACOL RES, V133, P170, DOI 10.1016/j.phrs.2018.04.009
   Enright EF, 2017, MOL PHARMACEUT, V14, P1251, DOI 10.1021/acs.molpharmaceut.6b01155
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Everard A, 2011, DIABETES, V60, P2775, DOI 10.2337/db11-0227
   Ezzati M, 2017, LANCET, V390, P2627, DOI 10.1016/S0140-6736(17)32129-3
   Falony G, 2016, SCIENCE, V352, P560, DOI 10.1126/science.aad3503
   Frost G, 2014, NAT COMMUN, V5, DOI 10.1038/ncomms4611
   Garnett JP, 2013, THORAX, V68, P835, DOI 10.1136/thoraxjnl-2012-203178
   Goodrich JK, 2014, CELL, V159, P789, DOI 10.1016/j.cell.2014.09.053
   Haro C, 2016, J CLIN ENDOCR METAB, V101, P232, DOI 10.1210/jc.2015-3351
   HOPPEL CL, 1980, AM J PHYSIOL, V238, pE409, DOI 10.1152/ajpendo.1980.238.5.E409
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Jackson MA, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-018-05184-7
   Jones BV, 2008, P NATL ACAD SCI USA, V105, P13580, DOI 10.1073/pnas.0804437105
   Karlsson CLJ, 2012, OBESITY, V20, P2257, DOI 10.1038/oby.2012.110
   Koves TR, 2008, CELL METAB, V7, P45, DOI 10.1016/j.cmet.2007.10.013
   Le Chatelier E, 2013, NATURE, V500, P541, DOI 10.1038/nature12506
   Lee H, 2018, GUT MICROBES, V9, P155, DOI 10.1080/19490976.2017.1405209
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Maidak BL, 2001, NUCLEIC ACIDS RES, V29, P173, DOI 10.1093/nar/29.1.173
   Maniar K, 2017, MED HYPOTHESES, V104, P117, DOI 10.1016/j.mehy.2017.06.001
   Mardinoglu A, 2016, CELL METAB, V23, P10, DOI 10.1016/j.cmet.2015.12.012
   Martinez I, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0015046
   Marupuru S, 2017, BRAZ J INFECT DIS, V21, P312, DOI 10.1016/j.bjid.2017.01.001
   Mihalik SJ, 2010, OBESITY, V18, P1695, DOI 10.1038/oby.2009.510
   Monami M, 2012, ADV THER, V29, P14, DOI 10.1007/s12325-011-0088-z
   Muoio DM, 2012, CELL METAB, V15, P595, DOI 10.1016/j.cmet.2012.04.010
   Nakamura H, 2014, NUTR DIABETES, V4, DOI 10.1038/nutd.2014.32
   Olivares M, 2018, DIABETOLOGIA, V61, P1838, DOI 10.1007/s00125-018-4647-6
   Patkee WRA, 2016, J CELL MOL MED, V20, P758, DOI 10.1111/jcmm.12784
   Patterson E, 2016, POSTGRAD MED J, V92, P286, DOI 10.1136/postgradmedj-2015-133285
   Pedersen HK, 2016, NATURE, V535, P376, DOI 10.1038/nature18646
   PENTIKAINEN PJ, 1990, ANN MED, V22, P307, DOI 10.3109/07853899009147912
   Ramakrishna BS, 2013, J GASTROEN HEPATOL, V28, P9, DOI 10.1111/jgh.12294
   Rotella CM, 2006, CURR DIABETES REV, V2, P307, DOI 10.2174/157339906777950651
   Schneeberger M, 2015, SCI REP-UK, V5, DOI 10.1038/srep16643
   Segata N, 2011, GENOME BIOL, V12, DOI 10.1186/gb-2011-12-6-r60
   Sender R, 2016, PLOS BIOL, V14, DOI 10.1371/journal.pbio.1002533
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Singhal A, 2014, SCI TRANSL MED, V6, DOI 10.1126/scitranslmed.3009885
   Sousa T, 2008, INT J PHARMACEUT, V363, P1, DOI 10.1016/j.ijpharm.2008.07.009
   Straczkowski M, 2004, DIABETES, V53, P1215, DOI 10.2337/diabetes.53.5.1215
   Summers SA, 2005, DIABETES, V54, P591, DOI 10.2337/diabetes.54.3.591
   Suvitaival T, 2018, METABOLISM, V78, P1, DOI 10.1016/j.metabol.2017.08.014
   Suzuki S, 2016, SCI REP-UK, V6, DOI 10.1038/srep38299
   Taras D, 2002, INT J SYST EVOL MICR, V52, P423, DOI 10.1099/00207713-52-2-423
   Wang K, 2019, CELL REP, V26, P222, DOI 10.1016/j.celrep.2018.12.028
   Wilkinson EM, 2018, MATURITAS, V112, P53, DOI 10.1016/j.maturitas.2018.03.012
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Wu TR, 2019, GUT, V68, P248, DOI 10.1136/gutjnl-2017-315458
   Xia Jianguo, 2016, Curr Protoc Bioinformatics, V55, DOI 10.1002/cpbi.11
   Yan XF, 2016, J DIABETES RES, V2016, DOI 10.1155/2016/2093171
   Zambell KL, 2003, J NUTR, V133, P3509, DOI 10.1093/jn/133.11.3509
   Zhang WD, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0184105
NR 72
TC 27
Z9 29
U1 0
U2 15
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1499-2671
EI 2352-3840
J9 CAN J DIABETES
JI Can. J. Diabetes
PD MAR
PY 2020
VL 44
IS 2
BP 146
EP +
DI 10.1016/j.jcjd.2019.05.008
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA KS0RZ
UT WOS:000518020500007
PM 31445961
DA 2023-06-08
ER

PT J
AU Wang, XR
   Huang, HM
   Zhu, YY
   Li, SL
   Zhang, PF
   Jiang, JJ
   Xi, CX
   Wu, LL
   Gao, XL
   Fu, YY
   Zhang, DH
   Chen, YQ
   Hu, SH
   Lai, JB
AF Wang, Xiaorong
   Huang, Huimin
   Zhu, Yiyi
   Li, Shaoli
   Zhang, Peifen
   Jiang, Jiajun
   Xi, Caixi
   Wu, Lingling
   Gao, Xingle
   Fu, Yaoyang
   Zhang, Danhua
   Chen, Yiqing
   Hu, Shaohua
   Lai, Jianbo
TI Metformin acts on the gut-brain axis to ameliorate antipsychotic-
   induced metabolic dysfunction
SO BIOSCIENCE TRENDS
LA English
DT Review
DE antipsychotic-induced metabolic dysfunction; gut-brain axis; gut
   microbiota; metformin; hypothalamus; neuropeptide
ID INDUCED WEIGHT-GAIN; ACTIVATED PROTEIN-KINASE; CHAIN FATTY-ACIDS;
   BODY-WEIGHT; ATYPICAL ANTIPSYCHOTICS; HYPOTHALAMIC REGULATION; PSYCHOTIC
   DISORDERS; INSULIN-RESISTANCE; CHRONIC OLANZAPINE; POTENTIAL ROLE
AB Antipsychotic-induced metabolic dysfunction (AIMD) is an intractable clinical challenge worldwide. The situation is becoming more critical as second-generation antipsychotics (SGAs), to a great extent, have replaced the role of first-generation antipsychotics in managing major psychiatric disorders. Although the exact mechanisms for developing AIMD is intricate, emerging evidence has indicated the involvement of the microbiota-gut-brain axis in AIMD. SGAs treatment may change the diversity and compositions of intestinal flora (e.g., decreased abundance of Bacteroidetes and Akkermansia muciniphila, and increased Firmicutes). Short-chain fatty acids and other metabolites derived from gut microbiota, on the one hand, can regulate the activity of intestinal endocrine cells and their secretion of satiety hormones (e.g., glucagon-like peptide 1, peptide YY, cholecystokinin and ghrelin); on the other hand, can activate the vagus nerve or transport into the brain to exert a central modulation of foraging behaviors via binding to neuropeptide receptors. Interestingly, metformin, a classical antidiabetic agent, is capable of alleviating AIMD possibly by regulating the microbiotagut-brain axis. That is, metformin can not only partially reverse the alterations of gut microbial communities due to SGAs treatment, but also play a positive role in rectifying the disturbances of peripheral and central satiety-related neuropeptides. Current evidence has indicated a promising role for metformin on ameliorating AMID, but further verifications in well-designed clinical trials are still warranted.
C1 [Wang, Xiaorong; Huang, Huimin; Zhu, Yiyi; Li, Shaoli; Zhang, Peifen; Xi, Caixi; Wu, Lingling; Gao, Xingle; Fu, Yaoyang; Zhang, Danhua; Chen, Yiqing; Hu, Shaohua; Lai, Jianbo] Zhejiang Univ, Affiliated Hosp 1, Dept Psychiat, Sch Med, 79 Qingchun Rd, Hangzhou 310003, Zhejiang, Peoples R China.
   [Wang, Xiaorong; Jiang, Jiajun; Hu, Shaohua; Lai, Jianbo] Key Lab Mental Disorders Management Zhejiang Prov, Hangzhou, Zhejiang, Peoples R China.
   [Wang, Xiaorong; Hu, Shaohua; Lai, Jianbo] Zhejiang Univ, Brain Res Inst, Hangzhou, Zhejiang, Peoples R China.
   [Wang, Xiaorong; Hu, Shaohua; Lai, Jianbo] Zhejiang Engn Ctr Math Mental Hlth, Hangzhou, Zhejiang, Peoples R China.
   [Huang, Huimin; Zhu, Yiyi] Wenzhou Med Univ, Wenzhou, Zhejiang, Peoples R China.
C3 Zhejiang University; Zhejiang University; Wenzhou Medical University
RP Hu, SH; Lai, JB (通讯作者)，Zhejiang Univ, Affiliated Hosp 1, Dept Psychiat, Sch Med, 79 Qingchun Rd, Hangzhou 310003, Zhejiang, Peoples R China.
EM dorhushaohua@zju.edu.cn; laijianbo@zju.edu.cn
RI Lai, Jianbo/CAI-8171-2022
OI Lai, Jianbo/0000-0002-8137-7701
CR Adeneye AA, 2011, INDIAN J EXP BIOL, V49, P332
   Alvarez-Jimenez M, 2008, CNS DRUGS, V22, P547, DOI 10.2165/00023210-200822070-00002
   Andersson U, 2004, J BIOL CHEM, V279, P12005, DOI 10.1074/jbc.C300557200
   Aubert G, 2011, METABOLISM, V60, P327, DOI 10.1016/j.metabol.2010.02.007
   Bahr SM, 2015, TRANSL PSYCHIAT, V5, DOI 10.1038/tp.2015.135
   Bahr SM, 2015, EBIOMEDICINE, V2, P1725, DOI 10.1016/j.ebiom.2015.10.018
   Baptista T, 2006, CAN J PSYCHIAT, V51, P192, DOI 10.1177/070674370605100310
   Barton BB, 2020, EXPERT OPIN DRUG SAF, V19, P295, DOI 10.1080/14740338.2020.1713091
   Bray GA, 2012, DIABETES CARE, V35, P731, DOI 10.2337/dc11-1299
   Byrne CS, 2016, AM J CLIN NUTR, V104, P5, DOI 10.3945/ajcn.115.126706
   Chambers ES, 2015, GUT, V64, P1744, DOI 10.1136/gutjnl-2014-307913
   Coyral-Castel S, 2008, J NEUROENDOCRINOL, V20, P335, DOI 10.1111/j.1365-2826.2007.01643.x
   Cubeddu LX, 2000, N-S ARCH PHARMACOL, V361, P85, DOI 10.1007/s002109900152
   Davey KJ, 2013, TRANSL PSYCHIAT, V3, DOI 10.1038/tp.2013.83
   Davey KJ, 2012, PSYCHOPHARMACOLOGY, V221, P155, DOI 10.1007/s00213-011-2555-2
   den Besten G, 2013, J LIPID RES, V54, P2325, DOI 10.1194/jlr.R036012
   Elbere I, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0204317
   Ellul P, 2018, CNS DRUGS, V32, P1103, DOI 10.1007/s40263-018-0571-z
   Evers SS, 2017, J PSYCHOPHARMACOL, V31, P1437, DOI 10.1177/0269881117724749
   Flowers SA, 2019, PHARMACOTHERAPY, V39, P161, DOI 10.1002/phar.2214
   Flowers SA, 2017, PHARMACOTHERAPY, V37, P261, DOI 10.1002/phar.1890
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Frost G, 2014, NAT COMMUN, V5, DOI 10.1038/ncomms4611
   Furness JB, 2013, NAT REV GASTRO HEPAT, V10, P729, DOI 10.1038/nrgastro.2013.180
   Han M, 2008, PSYCHONEUROENDOCRINO, V33, P569, DOI 10.1016/j.psyneuen.2008.01.018
   Huang DQ, 2021, PSYCHOPHARMACOLOGY, V238, P2543, DOI 10.1007/s00213-021-05878-9
   Kau AL, 2011, NATURE, V474, P327, DOI 10.1038/nature10213
   Latorre R, 2016, NEUROGASTROENT MOTIL, V28, P620, DOI 10.1111/nmo.12754
   Lee CK, 2012, DIABETES METAB J, V36, P293, DOI 10.4093/dmj.2012.36.4.293
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Leucht S, 2009, LANCET, V373, P31, DOI 10.1016/S0140-6736(08)61764-X
   Li B, 2006, BRAIN RES, V1118, P1, DOI 10.1016/j.brainres.2006.08.032
   Lian JM, 2014, PSYCHONEUROENDOCRINO, V48, P77, DOI 10.1016/j.psyneuen.2014.06.010
   Lis M, 2020, PSYCHONEUROENDOCRINO, V119, DOI 10.1016/j.psyneuen.2020.104744
   Lord CC, 2017, J CLIN INVEST, V127, P3408, DOI 10.1172/JCI93362
   Luo C, 2020, PSYCHOPHARMACOLOGY, V237, P2257, DOI 10.1007/s00213-020-05524-w
   Lv WS, 2012, BRAIN RES, V1444, P11, DOI 10.1016/j.brainres.2012.01.028
   Ma W, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.01336
   Maier L, 2018, NATURE, V555, P623, DOI 10.1038/nature25979
   Minokoshi Y, 2004, NATURE, V428, P569, DOI 10.1038/nature02440
   Mirshamsi S, 2004, BMC NEUROSCI, V5, DOI 10.1186/1471-2202-5-54
   Morgan AP, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0115225
   Morrison JA, 2002, AM J PSYCHIAT, V159, P655, DOI 10.1176/appi.ajp.159.4.655
   Newcomer JW, 2005, CNS DRUGS, V19, P1
   Parsons B, 2009, SCHIZOPHR RES, V110, P103, DOI 10.1016/j.schres.2008.09.025
   Pastor-Villaescusa B, 2021, BIOMED PHARMACOTHER, V134, DOI 10.1016/j.biopha.2020.111117
   Potvin Stephane, 2015, Can J Psychiatry, V60, pS26
   Sakakibara S, 2006, BIOCHEM BIOPH RES CO, V344, P597, DOI 10.1016/j.bbrc.2006.03.176
   Sandhu KV, 2017, TRANSL RES, V179, P223, DOI 10.1016/j.trsl.2016.10.002
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Siskind DJ, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0156208
   Tarricone I, 2010, PSYCHOL MED, V40, P187, DOI 10.1017/S0033291709990407
   Tolhurst G, 2012, DIABETES, V61, P364, DOI 10.2337/db11-1019
   van Bennekom MWHL, 2013, J PSYCHOPHARMACOL, V27, P327, DOI 10.1177/0269881113477709
   Weersma RK, 2020, GUT, V69, P1510, DOI 10.1136/gutjnl-2019-320204
   Wu RR, 2008, AM J PSYCHIAT, V165, P352, DOI 10.1176/appi.ajp.2007.07010079
   [夏金校 XIA Jinxiao], 2011, [中国临床药理学杂志, The Chinese Journal of Clinical Pharmacology], V27, P417
   Yang YF, 2012, BEHAV BRAIN FUNCT, V8, DOI 10.1186/1744-9081-8-11
   Yuan XX, 2018, SCHIZOPHR RES, V201, P299, DOI 10.1016/j.schres.2018.05.017
   Zhang JP, 2013, INT J NEUROPSYCHOPH, V16, P1205, DOI 10.1017/S1461145712001277
NR 60
TC 2
Z9 2
U1 1
U2 11
PU IRCA-BSSA
PI TOKYO
PA PEARL CITY KOISHIKAWA 603, 2-4-5 KASUGA, BUNKYO-KU, TOKYO, 112-0003,
   JAPAN
SN 1881-7815
EI 1881-7823
J9 BIOSCI TRENDS
JI BioSci. Trends
PD OCT
PY 2021
VL 15
IS 5
BP 321
EP 329
DI 10.5582/bst.2021.01317
PG 9
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Life Sciences & Biomedicine - Other Topics
GA WX4FW
UT WOS:000718554600008
PM 34588398
OA gold
DA 2023-06-08
ER

PT J
AU Bryrup, T
   Thomsen, CW
   Kern, T
   Allin, KH
   Brandslund, I
   Jorgensen, NR
   Vestergaard, H
   Hansen, T
   Hansen, TH
   Pedersen, O
   Nielsen, T
AF Bryrup, Thomas
   Thomsen, Caecilie W.
   Kern, Timo
   Allin, Kristine H.
   Brandslund, Ivan
   Jorgensen, Nikias R.
   Vestergaard, Henrik
   Hansen, Torben
   Hansen, Tue H.
   Pedersen, Oluf
   Nielsen, Trine
TI Metformin-induced changes of the gut microbiota in healthy young men:
   results of a non-blinded, one-armed intervention study
SO DIABETOLOGIA
LA English
DT Article
DE Drug therapy; Gut microbiota; Intervention; Metformin; Microbiome;
   Microbiota; Type 2 diabetes
ID GLUCOSE; GLUCONEOGENESIS; BIGUANIDES; METAGENOME; HISTAMINE; GLUCAGON;
   REVEALS; PATHWAY; INSULIN
AB Aims/hypothesis Individuals with type 2 diabetes have an altered bacterial composition of their gut microbiota compared with non-diabetic individuals. However, these alterations may be confounded by medication, notably the blood-glucose-lowering biguanide, metformin. We undertook a clinical trial in healthy and previously drug-free men with the primary aim of investigating metformin-induced compositional changes in the non-diabetic state. A secondary aim was to examine whether the pre-treatment gut microbiota was related to gastrointestinal adverse effects during metformin treatment.
   Methods Twenty-seven healthy young Danish men were included in an 18-week one-armed crossover trial consisting of a pre-intervention period, an intervention period and a post-intervention period, each period lasting 6 weeks. Inclusion criteria were men of age 18-35 years, BMI between 18.5 kg/m(2) and 27.5 kg/m(2), HbA(1c) < 39 mmol/mol (5.7%) and plasma creatinine within the normal range. No prescribed medication, including antibiotics, for 2 months prior to recruitment were allowed and no previous gastrointestinal surgery, discounting appendectomy or chronic illness requiring medical treatment. During the intervention the participants were given metformin up to 1 g twice daily. Participants were examined five times in the fasting state with blood sampling and recording of gastrointestinal symptoms. Examinations took place at Frederiksberg Hospital, Denmark before and after the pre-intervention period, halfway through and immediately after the end of intervention and after the wash-out period. Faecal samples were collected at nine evenly distributed time points, and bacterial DNA was extracted and subjected to 16S rRNA gene amplicon sequencing in order to evaluate gut microbiota composition. Subjective gastrointestinal symptoms were reported at each visit.
   Results Data from participants who completed visit 1 (n = 23) are included in analyses. For the primary outcome the relative abundance of 11 bacterial genera significantly changed during the intervention but returned to baseline levels after treatment cessation. In line with previous reports, we observed a reduced abundance of Intestinibacter spp. and Clostridium spp., as well as an increased abundance of Escherichia/Shigella spp. and Bilophila wadsworthia. The relative abundance at baseline of 12 bacterial genera predicted self-reported gastrointestinal adverse effects.
   Conclusions/interpretation Intake of metformin changes the gut microbiota composition in normoglycaemic young men. The microbiota changes induced by metformin extend and validate previous reports in individuals with type 2 diabetes. Secondary analyses suggest that pre-treatment gut microbiota composition may be a determinant for development of gastrointestinal adverse effects following metformin intake. These results require further investigation and replication in larger prospective studies.
C1 [Bryrup, Thomas; Thomsen, Caecilie W.; Kern, Timo; Allin, Kristine H.; Vestergaard, Henrik; Hansen, Torben; Hansen, Tue H.; Pedersen, Oluf; Nielsen, Trine] Univ Copenhagen, Novo Nordisk Fdn Ctr Basic Metab Res, Fac Hlth & Med Sci, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark.
   [Allin, Kristine H.] Bispebjerg & Frederiksberg Hosp, Ctr Clin Res & Prevent, Copenhagen, Denmark.
   [Brandslund, Ivan] Lillebaelt Hosp, Dept Biochem & Immunol, Vejle, Denmark.
   [Brandslund, Ivan] Univ Southern Denmark, Inst Reg Hlth Res, Odense C, Denmark.
   [Jorgensen, Nikias R.] Rigshosp, Dept Clin Biochem, Copenhagen, Denmark.
   [Jorgensen, Nikias R.] Univ Southern Denmark, Odense Patient Data Explorat Network OPEN, Odense Univ Hosp, Inst Clin Res, Odense, Denmark.
   [Vestergaard, Henrik] Steno Diabet Ctr Copenhagen, Gentofte, Denmark.
   [Hansen, Torben] Univ Southern Denmark, Fac Hlth Sci, Odense, Denmark.
   [Hansen, Tue H.] Slagelse Hosp, Dept Cardiol & Endocrinol, Slagelse, Denmark.
C3 Novo Nordisk Foundation; University of Copenhagen; University of
   Copenhagen; Bispebjerg Hospital; University of Southern Denmark;
   Rigshospitalet; University of Copenhagen; University of Southern
   Denmark; Odense University Hospital; Steno Diabetes Center; University
   of Southern Denmark
RP Pedersen, O; Nielsen, T (通讯作者)，Univ Copenhagen, Novo Nordisk Fdn Ctr Basic Metab Res, Fac Hlth & Med Sci, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark.
EM oluf@sund.ku.dk; trine.nielsen@sund.ku.dk
RI Pedersen, Oluf/Z-1731-2019; Bryrup, Thomas/AAJ-1302-2021; Allin,
   Kristine Højgaard/ABG-3463-2021; Pedersen, Oluf/AAG-8015-2020; Hansen,
   Tue Haldor/S-7724-2016; Nielsen, trine/HJZ-4867-2023
OI Pedersen, Oluf/0000-0002-3321-3972; Hansen, Tue
   Haldor/0000-0001-5948-8993; Nielsen, trine/0000-0002-2066-7895;
   Brandslund, Ivan/0000-0002-4203-5442; Bryrup,
   Thomas/0000-0001-8533-6766; Kern, Timo/0000-0001-7139-9766; Allin,
   Kristine Hojgaard/0000-0002-6880-5759; Jorgensen, Niklas
   Rye/0000-0001-9624-5210; Vestergaard, Henrik/0000-0003-3090-269X;
   Hansen, Torben/0000-0001-8748-3831
FU Danish Diabetes Association; Novo Nordisk Foundation [NNF14OC00128];
   Novo Nordisk Foundation for Basic Metabolic Research; Hagedorn Prize
FX The project was financed by research grants from the Danish Diabetes
   Association (received by TN), The Novo Nordisk Foundation (grant number
   NNF14OC00128), internal funding at the Novo Nordisk Foundation for Basic
   Metabolic Research and the Hagedorn Prize (received by OP).
CR BAILEY CJ, 1992, DIABETES CARE, V15, P755, DOI 10.2337/diacare.15.6.755
   BONORA E, 1984, CURR MED RES OPIN, V9, P47, DOI 10.1185/03007998409109558
   Buse JB, 2016, DIABETES CARE, V39, P198, DOI 10.2337/dc15-0488
   Callahan BJ, 2016, NAT METHODS, V13, P581, DOI [10.1038/NMETH.3869, 10.1038/nmeth.3869]
   Coughlan KA, 2014, DIABET METAB SYND OB, V7, P241, DOI 10.2147/DMSO.S43731
   Dao MC, 2016, GUT, V65, P426, DOI 10.1136/gutjnl-2014-308778
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Duca FA, 2015, NAT MED, V21, P506, DOI 10.1038/nm.3787
   Elbere I, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0204317
   Falony G, 2016, SCIENCE, V352, P560, DOI 10.1126/science.aad3503
   Foretz M, 2010, J CLIN INVEST, V120, P2355, DOI 10.1172/JCI40671
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Garber AJ, 1997, AM J MED, V103, P491, DOI 10.1016/S0002-9343(97)00254-4
   Garner MR, 2002, SYST APPL MICROBIOL, V25, P498, DOI 10.1078/07232020260517625
   Guo XF, 2017, BMC GENOMICS, V18, DOI 10.1186/s12864-017-4195-3
   Hiippala K, 2016, FRONT MICROBIOL, V7, DOI 10.3389/fmicb.2016.01706
   Ikeda T, 2000, BIOCHEM PHARMACOL, V59, P887, DOI 10.1016/S0006-2952(99)00396-2
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Lavelle A, 2015, GUT, V64, P1553, DOI 10.1136/gutjnl-2014-307873
   Madiraju AK, 2014, NATURE, V510, P542, DOI 10.1038/nature13270
   Maintz L, 2007, AM J CLIN NUTR, V85, P1185, DOI 10.1093/ajcn/85.5.1185
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Miller RA, 2013, NATURE, V494, P256, DOI 10.1038/nature11808
   Pedersen C, 2016, BRIT J NUTR, V116, P1869, DOI 10.1017/S0007114516004086
   Pingitore A, 2017, DIABETES OBES METAB, V19, P257, DOI 10.1111/dom.12811
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Sato J, 2014, DIABETES CARE, V37, P2343, DOI 10.2337/dc13-2817
   Shapiro H, 2018, J EXP MED, V215, P383, DOI 10.1084/jem.20171965
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Wang Q, 2007, APPL ENVIRON MICROB, V73, P5261, DOI 10.1128/AEM.00062-07
   WARNICK GR, 1990, CLIN CHEM, V36, P15
   Williams BL, 2012, MBIO, V3, DOI 10.1128/mBio.00261-11
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Yee SW, 2015, J PHARMACOKINET PHAR, V42, P463, DOI 10.1007/s10928-015-9436-y
   Zhernakova A, 2016, SCIENCE, V352, P565, DOI 10.1126/science.aad3369
   Zhou GC, 2001, J CLIN INVEST, V108, P1167, DOI 10.1172/JCI200113505
NR 38
TC 89
Z9 93
U1 1
U2 19
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0012-186X
EI 1432-0428
J9 DIABETOLOGIA
JI Diabetologia
PD JUN
PY 2019
VL 62
IS 6
BP 1024
EP 1035
DI 10.1007/s00125-019-4848-7
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA HX8FC
UT WOS:000467640700015
PM 30904939
OA Green Published, hybrid
DA 2023-06-08
ER

PT J
AU Ermolenko, E
   Simanenkova, A
   Voropaeva, L
   Lavrenova, N
   Kotyleva, M
   Minasian, S
   Chernikova, A
   Timkina, N
   Gladyshev, N
   Dmitriev, A
   Suvorov, A
   Galagudza, M
   Karonova, T
AF Ermolenko, Elena
   Simanenkova, Anna
   Voropaeva, Lyubov
   Lavrenova, Nadezhda
   Kotyleva, Maryna
   Minasian, Sarkis
   Chernikova, Alena
   Timkina, Natalya
   Gladyshev, Nikita
   Dmitriev, Alexander
   Suvorov, Alexander
   Galagudza, Michael
   Karonova, Tatiana
TI Metformin Influence on the Intestinal Microbiota and Organism of Rats
   with Metabolic Syndrome
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE metformin; metabolic syndrome; impaired glucose tolerance; intestinal
   microbiome; myocardial infarction; cardioprotection
ID HIGH-FAT DIET; AKKERMANSIA-MUCINIPHILA; GUT MICROBIOME;
   FAECALIBACTERIUM-PRAUSNITZII; INSULIN SENSITIVITY; TYPE-2; INDIVIDUALS;
   HYPERGLYCEMIA; INFLAMMATION; ASSOCIATION
AB Metformin is a first-line drug for DM2 treatment and prevention, but its complex effect on impaired glucose tolerance (IGT), including its influence on myocardial resistance to ischemia-reperfusion injury, is not completely studied. We aimed to evaluate the influence of metformin on the intestinal microbiota (IM), metabolism, and functional and morphological characteristics of myocardium in rats with IGT. IGT was modelled in SPF Wistar rats with a high-fat diet and streptozotocin and nicotinamide injection. Rats were divided into three groups: IGT (without treatment), IGT MET (metformin therapy), and CRL (without IGT induction and treatment). IGT group was characterized by: higher body weight, increased serum glucose and total cholesterol levels, atherogenic coefficient, impairment in the functional parameters of the isolated heart during perfusion, and larger myocardium infarction (MI) size in comparison with the CRL group. IM of IGT rats differed from that of CRL: an increase of Bacteroides, Acinetobacter, Akkermansia, Roseburia, and a decrease of Lactobacillus genera representation. Metformin therapy led to the diminishing of metabolic syndrome (MS) symptoms, which correlated with IM restoration, especially with the growth of Akkermansia spp. and decline of Roseburia populations and their influence on other members of IM. The obtained results allow us to consider from a new point of view the expediency of probiotic A. muciniphila use for MS treatment.
C1 [Ermolenko, Elena; Voropaeva, Lyubov; Lavrenova, Nadezhda; Kotyleva, Maryna; Gladyshev, Nikita; Dmitriev, Alexander; Suvorov, Alexander] Fed State Budgetary Inst, Inst Expt Med, St Petersburg 197376, Russia.
   [Simanenkova, Anna; Minasian, Sarkis; Chernikova, Alena; Timkina, Natalya; Galagudza, Michael; Karonova, Tatiana] Almazov Natl Med Res Ctr, St Petersburg 197341, Russia.
C3 Institute of Experimental Medicine; Almazov National Medical Research
   Centre
RP Ermolenko, E (通讯作者)，Fed State Budgetary Inst, Inst Expt Med, St Petersburg 197376, Russia.
EM lermolenkol@yandex.ru; annasimanenkova@mail.ru; lu_bashka@mail.ru;
   nadezhda.lavrenova.vrn@gmail.com; mariha.lenivaya@mail.ru;
   carkis@yandex.ru; arabicaa@gmail.com; n.timkina2014@yandex.ru;
   krinege@mail.ru; admitriev10@yandex.ru; navivus2@gmail.com;
   galagudza@almazovcentre.ru; karonova@mail.ru
RI ; Suvorov, Alexander/J-6921-2013
OI Gladyshev, Nikita/0000-0003-2732-5676; Suvorov,
   Alexander/0000-0003-2312-5589; Chernikova, Alena/0000-0002-4878-6909;
   Simanenkova, Anna/0000-0003-3300-1280; Alferova,
   Lyubov/0000-0002-0052-0896
FU Ministry of Science and Higher Education of the Russian Federation
   [075-15-2020-902]
FX The work was supported by the Ministry of Science and Higher Education
   of the Russian Federation 075-15-2020-902 Federal State Budgetary
   Scientific Institution "Institute of Experimental Medicine" (FSBSI
   "IEM") Scientific and Educational Center "Molecular bases of interaction
   of microorganisms and human" of the world-class research center "Center
   for personalized Medicine" FSBSI "IEM".
CR Adeshirlarijaney A, 2019, AM J PHYSIOL-ENDOC M, V317, pE1121, DOI 10.1152/ajpendo.00245.2019
   Andreasen AS, 2010, BRIT J NUTR, V104, P1831, DOI 10.1017/S0007114510002874
   Aron RAC, 2021, MICROORGANISMS, V9, DOI 10.3390/microorganisms9030618
   Barreto-Torres G, 2015, AM J PHYSIOL-HEART C, V308, pH749, DOI 10.1152/ajpheart.00414.2014
   Bayrasheva VK, 2016, J DIABETES RES, V2016, DOI 10.1155/2016/8317850
   Bhardwaj S., 2013, INT J PHARM BIOL SCI, V3, P359, DOI DOI 10.1016/J.DSX.2017.03.038
   BONORA E, 1984, CURR MED RES OPIN, V9, P47, DOI 10.1185/03007998409109558
   Borshcev Yu Yu, 2016, Ross Fiziol Zh Im I M Sechenova, V102, P1323
   Borshchev YY, 2021, B EXP BIOL MED+, V170, P613, DOI 10.1007/s10517-021-05117-3
   Borshchev YY, 2019, B EXP BIOL MED+, V166, P440, DOI 10.1007/s10517-019-04368-5
   Brunkwall L, 2017, DIABETOLOGIA, V60, P943, DOI 10.1007/s00125-017-4278-3
   Burovenko IY, 2020, B EXP BIOL MED+, V168, P309, DOI 10.1007/s10517-020-04697-w
   Cani PD, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.01765
   Cao BY, 2016, J TRADIT CHIN MED, V36, P768
   Chen P, 2014, NUTRITION, V30, P1061, DOI 10.1016/j.nut.2014.03.022
   Dao MC, 2016, GUT, V65, P426, DOI 10.1136/gutjnl-2014-308778
   de Groot P, 2020, GUT, V69, P502, DOI 10.1136/gutjnl-2019-318320
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   DeSantis TZ, 2006, APPL ENVIRON MICROB, V72, P5069, DOI 10.1128/AEM.03006-05
   Esposito K, 2004, NUTR METAB CARDIOVAS, V14, P228, DOI 10.1016/S0939-4753(04)80048-6
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Festi D, 2014, WORLD J GASTROENTERO, V20, P16079, DOI 10.3748/wjg.v20.i43.16079
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Fuentes S, 2014, ISME J, V8, P1621, DOI 10.1038/ismej.2014.13
   Galagudza M M, 2006, Ross Fiziol Zh Im I M Sechenova, V92, P284
   Gerard C, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00029
   Hampe CS, 2017, ENDOCRINE, V58, P207, DOI 10.1007/s12020-017-1433-z
   Hariri M, 2015, GENES NUTR, V10, DOI 10.1007/s12263-015-0503-1
   Helmstadter J, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10081175
   Hill C, 2014, NAT REV GASTRO HEPAT, V11, P506, DOI 10.1038/nrgastro.2014.66
   Koliada A, 2017, BMC MICROBIOL, V17, DOI 10.1186/s12866-017-1027-1
   Kornyushin OV, 2019, B EXP BIOL MED+, V168, P210, DOI 10.1007/s10517-019-04676-w
   Kravchuk E, 2011, EXP DIABETES RES, DOI 10.1155/2011/907496
   Lee CB, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22073566
   Li X, 2016, J APPL MICROBIOL, V121, P1727, DOI 10.1111/jam.13276
   Luo F, 2019, CARDIOVASC DIABETOL, V18, DOI 10.1186/s12933-019-0860-y
   Machiels K, 2014, GUT, V63, P1275, DOI 10.1136/gutjnl-2013-304833
   Minasian SM, 2013, J CARDIOTHORAC SURG, V8, DOI 10.1186/1749-8090-8-60
   Montandon SA, 2017, GENES-BASEL, V8, DOI 10.3390/genes8100250
   Owen MR, 2000, BIOCHEM J, V348, P607, DOI 10.1042/0264-6021:3480607
   Pernicova I, 2014, NAT REV ENDOCRINOL, V10, P143, DOI 10.1038/nrendo.2013.256
   Rajilic-Stojanovic M, 2014, FEMS MICROBIOL REV, V38, P996, DOI 10.1111/1574-6976.12075
   Remely M, 2016, ENDOCR METAB IMMUNE, V16, P99, DOI 10.2174/1871530316666160831093813
   Rena G, 2017, DIABETOLOGIA, V60, P1577, DOI 10.1007/s00125-017-4342-z
   Rojas E., 2020, GAC M DICA CARACAS, V128, P480, DOI [10.47307/GMC.2020.128.4.5, DOI 10.47307/GMC.2020.128.4.5]
   Sarkar S., 2018, J PRACT CARDIOVASC S, V4, P10, DOI [10.4103/JPCS.JPCS_18_18, DOI 10.4103/JPCS.JPCS_18_18, 10.4103/jpcs.jpcs_18_18]
   Scott KP, 2008, APPL ENVIRON MICROB, V74, P3915, DOI 10.1128/AEM.02807-07
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Simanenkova A, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-86132-2
   Sokol H, 2009, INFLAMM BOWEL DIS, V15, P1183, DOI 10.1002/ibd.20903
   Stepensky D, 2002, DRUG METAB DISPOS, V30, P861, DOI 10.1124/dmd.30.8.861
   Suvorov A, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.01869
   Turnbaugh PJ, 2009, NATURE, V457, P480, DOI 10.1038/nature07540
   Vrieze A, 2012, GASTROENTEROLOGY, V143, P913, DOI 10.1053/j.gastro.2012.06.031
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Yin YN, 2010, WORLD J GASTROENTERO, V16, P3394, DOI 10.3748/wjg.v16.i27.3394
   Yun SI, 2009, J APPL MICROBIOL, V107, P1681, DOI 10.1111/j.1365-2672.2009.04350.x
   Zhang M, 2008, EXP DIABETES RES, DOI 10.1155/2008/704045
   Zhang Q, 2020, DIABET METAB SYND OB, V13, P5003, DOI 10.2147/DMSO.S286430
   Zhou GC, 2001, J CLIN INVEST, V108, P1167, DOI 10.1172/JCI200113505
   Zhou KQ, 2017, J FUNCT FOODS, V33, P194, DOI 10.1016/j.jff.2017.03.045
NR 61
TC 2
Z9 2
U1 7
U2 12
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JUN
PY 2022
VL 23
IS 12
AR 6837
DI 10.3390/ijms23126837
PG 20
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 2K8CY
UT WOS:000816558300001
PM 35743280
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Kang, J
   Li, CQ
   Gao, XH
   Liu, ZQ
   Chen, CA
   Luo, DQ
AF Kang, Jie
   Li, Chunqing
   Gao, Xuehui
   Liu, Zhiqin
   Chen, Chuan
   Luo, Duqiang
TI Metformin inhibits tumor growth and affects intestinal flora in diabetic
   tumor-bearing mice
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE Diabetes; Hepatocellular carcinoma; Intestinal flora; Metformin
ID GUT MICROBIOTA; CANCER
AB Many studies have found that diabetes increases the risk of some cancers such as hepatocellular carcinoma. However, there are few studies on the relationship between the two diseases and their effects on intestinal flora. Therefore, we used streptozotocin and high-fat diet to establish a mouse model of type 2 diabetes, and then inoculated the Huh-7 hepatocellular carcinoma cells to obtain mouse diabetic tumor model. Mice inoculated with Huh-7 cells alone served as control. The tumor size in the diabetic tumor group was significantly higher than that in the tumor group. Our study also showed that the expression levels of inflammation-related factors (TNF alpha, IL1 beta, IL-6, TLR4 and MCP1) in the diabetic tumor group were significantly higher than that in the tumor group. We found that metformin alleviated blood glucose level, reduced the expressions of inflammation-related factors and retarded xenograft tumor growth in the diabetic tumor group, but it couldn't reduce the tumor growth in the tumor group. Subsequent studies found that the content of some short chain fatty acids (SCFAs) including acetic acid, propionic acid and isobutyric acid decreased significantly in diabetic tumor group. Metformin increased short chain fatty acid levels (acetic acid, butyic acid and valeric acid) and enriched the abundance of SCFAproducing bacterial genera such as Ruminococcaceae, Clostridiales, Anaerovorax, Odoribacter and Marvinbryantia. In conclusion, type 2 diabetes could promote the growth of hepatoma cells in mice. Metformin could inhibit the growth of tumor under the condition of diabetes and play a role in the intestinal homeostasis in mice.
C1 [Kang, Jie; Li, Chunqing; Gao, Xuehui; Liu, Zhiqin; Chen, Chuan; Luo, Duqiang] Hebei Univ, Inst Life Sci & Green Dev, Coll Life Sci, Key Lab Microbial Div Res & Applicat Hebei Prov, Baoding 071002, Hebei, Peoples R China.
C3 Hebei University
RP Chen, CA; Luo, DQ (通讯作者)，Hebei Univ, Inst Life Sci & Green Dev, Coll Life Sci, Baoding 071002, Hebei, Peoples R China.
EM hyperchuan@163.com; duqiangluo@163.com
FU National Natural Science Foundation of China [31672070, 30901755];
   Changjiang Scholars and Innovative Research Team in University
   [IRT_15R16]
FX This work was funded by National Natural Science Foundation of China
   [31672070, 30901755], and Changjiang Scholars and Innovative Research
   Team in University [grant number IRT_15R16].
CR Abenavoli L, 2019, NUTRIENTS, V11, DOI 10.3390/nu11112690
   Abudawood M, 2019, J RES MED SCI, V24, DOI 10.4103/jrms.JRMS_242_19
   Aho VTE, 2019, EBIOMEDICINE, V44, P691, DOI 10.1016/j.ebiom.2019.05.064
   Barko PC, 2018, J VET INTERN MED, V32, P9, DOI 10.1111/jvim.14875
   Bonagiri P.R., 2020, CLIN DIABETES, V38, P256, DOI [10.2337/cd19-0077, DOI 10.2337/CD19-0077]
   Canfora EE, 2015, NAT REV ENDOCRINOL, V11, P577, DOI 10.1038/nrendo.2015.128
   Chen MY, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.02380
   Dong SW, 2021, FRONT ONCOL, V11, DOI 10.3389/fonc.2021.629666
   Duan WX, 2014, BIOMED RES INT, V2014, DOI 10.1155/2014/461917
   Elgendy M, 2019, CANCER CELL, V35, P798, DOI 10.1016/j.ccell.2019.03.007
   Farias AJ, 2020, JNCI CANCER SPECT, V4, DOI 10.1093/jncics/pkaa035
   Garg SK, 2014, DIABETES OBES METAB, V16, P97, DOI 10.1111/dom.12124
   Giovannucci E, 2010, DIABETES CARE, V33, P1674, DOI 10.2337/dc10-0666
   Gopalakrishnan V, 2018, CANCER CELL, V33, P570, DOI 10.1016/j.ccell.2018.03.015
   Granado-Serrano AB, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-38874-3
   Gristina V, 2015, BIOMED REP, V3, P131, DOI 10.3892/br.2014.399
   Gungor B, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0145878
   Gurung M, 2020, EBIOMEDICINE, V51, DOI 10.1016/j.ebiom.2019.11.051
   Kameyama K, 2014, MICROBES ENVIRON, V29, P427, DOI 10.1264/jsme2.ME14054
   Leng WL, 2021, DIABET METAB SYND OB, V14, P3673, DOI 10.2147/DMSO.S326378
   Li WJ, 2019, J EXP CLIN CANC RES, V38, DOI 10.1186/s13046-019-1309-6
   Lida N, 2019, INT J CANCER, V145, P2701, DOI 10.1002/ijc.32339
   Liu RT, 2020, BRAIN BEHAV IMMUN, V88, P308, DOI 10.1016/j.bbi.2020.03.026
   Liu S, 2020, MOL NEUROBIOL, V57, P5026, DOI 10.1007/s12035-020-02073-3
   Lu S, 2020, ANN TRANSL MED, V8, DOI 10.21037/atm.2020.01.101
   Ma LW, 2019, J EXP CLIN CANC RES, V38, DOI 10.1186/s13046-019-1090-6
   Ma ML, 2020, CELL CYCLE, V19, P2168, DOI 10.1080/15384101.2020.1796036
   Martin-Gallausiaux C, 2021, P NUTR SOC, V80, P37, DOI 10.1017/S0029665120006916
   Matthies C, 2000, INT J SYST EVOL MICR, V50, P1591, DOI 10.1099/00207713-50-4-1591
   Miller B, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22052757
   Morgan XC, 2012, GENOME BIOL, V13, DOI 10.1186/gb-2012-13-9-r79
   Ormerod KL, 2016, MICROBIOME, V4, DOI 10.1186/s40168-016-0181-2
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Rahman I, 2021, FRONT ONCOL, V10, DOI 10.3389/fonc.2020.600824
   Ramteke P, 2019, CANCERS, V11, DOI 10.3390/cancers11091402
   Rodriguez J, 2018, CURR OPIN CLIN NUTR, V21, P294, DOI 10.1097/MCO.0000000000000468
   Sah SP, 2016, PHARMACOL REP, V68, P1165, DOI 10.1016/j.pharep.2016.07.010
   Santos-Marcos JA, 2019, J NUTR BIOCHEM, V70, P1, DOI 10.1016/j.jnutbio.2019.03.017
   Song Y, 2020, FOOD RES INT, V137, DOI 10.1016/j.foodres.2020.109410
   Sun QH, 2021, J DIGEST DIS, V22, P246, DOI 10.1111/1751-2980.12988
   Tateishi R, 2021, J GASTROENTEROL, V56, P261, DOI 10.1007/s00535-020-01754-z
   Thingholm LB, 2019, CELL HOST MICROBE, V26, P252, DOI 10.1016/j.chom.2019.07.004
   Wan MLY, 2018, HEPATOBIL SURG NUTR, V7, P11, DOI 10.21037/hbsn.2017.12.07
   Wang JJ, 2019, FRONT MICROBIOL, V10, DOI 10.3389/fmicb.2019.00887
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Zhang ZW, 2021, PEERJ, V9, DOI 10.7717/peerj.10952
   Zheng JP, 2019, J NUTR BIOCHEM, V71, P16, DOI 10.1016/j.jnutbio.2019.05.013
   Zhuang YX, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0108444
NR 48
TC 6
Z9 6
U1 9
U2 26
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0014-2999
EI 1879-0712
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD DEC 5
PY 2021
VL 912
AR 174605
DI 10.1016/j.ejphar.2021.174605
EA NOV 2021
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA XQ7OH
UT WOS:000731733400003
PM 34757071
DA 2023-06-08
ER

PT J
AU He, DQ
   Han, H
   Fu, XD
   Liu, AB
   Zhan, YH
   Qiu, HY
   Md, LM
   Zhang, XF
   Wang, XJ
AF He, Daqiang
   Han, Hui
   Fu, Xiaodan
   Liu, Anbing
   Zhan, Yuhong
   Qiu, Haiyan
   Md, Lizhen Ma
   Zhang, Xianfeng
   Wang, Xianjun
TI Metformin Reduces Blood Glucose in Treatment-Naive Type 2 Diabetes by
   Altering the Gut Microbiome
SO CANADIAN JOURNAL OF DIABETES
LA English
DT Article
DE gut microbiome; metformin; T2D
ID INSULIN-RESISTANCE
AB Background: Our aim in this study was to better understand the causality of metformin and gut microbiome in the treatment of type 2 diabetes (T2D). Methods: This study was conducted on individuals with newly diagnosed and treatment-naive T2D. We used 16S rRNA sequencing to assess the effect of metformin on composition and diversity of the gut microbiota. We also compared the differences in relative abundance of gut microbiome at the genus level in patients with treatment-naive T2D before and after 2 months of metformin treatment. Spearman's rank correlation coefficient analysis was used to identify genus abundance in relation to blood glucose and related factors. Results: Metformin significantly reduced blood glucose and levels of the related factors in treatment naive individuals with T2D after 2 months of treatment. The 16S rRNA sequencing showed that metformin treatment altered composition and diversity of gut microbiome. Megamonas and Klebsiella in the T2D groups were significantly higher compared with the control group. Metformin treatment caused a significant reduction in Megamonas and Klebsiella. Spearman's rank correlation coefficient analysis showed a significant positive correlation between Megamonas and blood glucose, glycated hemoglobin (A1C), serum fructosamine and alanine aminotranferase (ALT). Klebsiella showed a significant positive correlation between A1C and ALT. Conclusion: Metformin reduces blood glucose in T2D by interacting with different gut bacteria, possibly Megamonas and Klebsiella pneumoniae.(c) 2021 Canadian Diabetes Association.
C1 [He, Daqiang; Liu, Anbing; Wang, Xianjun] Zhejiang Univ, Affiliated Hangzhou Peoples Hosp 1, Dept Lab Med, Sch Med, Hangzhou, Zhejiang, Peoples R China.
   [Han, Hui; Fu, Xiaodan; Zhan, Yuhong; Qiu, Haiyan] Zhejiang Univ, Affiliated Hangzhou Peoples Hosp 1, Dept Endocrinol, Sch Med, Hangzhou, Zhejiang, Peoples R China.
   [Md, Lizhen Ma; Zhang, Xianfeng] Zhejiang Univ, Affiliated Hangzhou Peoples Hosp 1, Dept Rheumatol, Sch Med, Hangzhou, Zhejiang, Peoples R China.
   [Wang, Xianjun] Zhejiang Univ Sch Med, Affiliated Hangzhou Peoples Hosp 1, Dept Lab Med, Sch Med, Hangzhou 310006, Zhejiang, Peoples R China.
C3 Zhejiang University; Zhejiang University; Zhejiang University
RP Wang, XJ (通讯作者)，Zhejiang Univ Sch Med, Affiliated Hangzhou Peoples Hosp 1, Dept Lab Med, Sch Med, Hangzhou 310006, Zhejiang, Peoples R China.
EM wangxianjun0525@163.com
RI Zhang, XZ/HJA-4189-2022; He, Daqiang/C-8264-2012; zhang,
   xian/GYA-0290-2022
FU Zhejiang Province Health Technology [2019RC235, 2019ZD014, 2020KY209];
   Hangzhou Health Science and Technology [A2020125]; Hangzhou Science and
   Technology [20150733Q10]
FX Acknowledgments This study was supported by Zhejiang Province Health
   Technology (Grant Nos. 2019RC235, 2019ZD014 and 2020KY209) , Hangzhou
   Health Science and Technology (Grant No. A2020125) and Hangzhou Science
   and Technology (Grant No. 20150733Q10) .
CR Barengolts E, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0194171
   Tonucci L, 2017, CRIT REV FOOD SCI, V57, P2296, DOI 10.1080/10408398.2014.934438
   Chen JW, 2019, BMC UROL, V19, DOI 10.1186/s12894-019-0506-0
   Chen W, 2019, J SURG RES, V239, P67, DOI 10.1016/j.jss.2018.12.004
   Chen XD, 2021, J MICROBIOL IMMUNOL, V54, P213, DOI 10.1016/j.jmii.2019.05.013
   Chen YX, 2019, BMC PHARMACOL TOXICO, V20, DOI 10.1186/s40360-019-0321-y
   Choi YH, 2007, INT J PHARM, V337, P194, DOI 10.1016/j.ijpharm.2007.01.001
   Diener C, 2020, MSYSTEMS, V5, DOI 10.1128/mSystems.00606-19
   Forslund K, 2017, NATURE, V545, P116, DOI 10.1038/nature22318
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Gaike AH, 2020, MSYSTEMS, V5, DOI 10.1128/mSystems.00578-19
   Greer RL, 2016, NAT COMMUN, V7, DOI 10.1038/ncomms13329
   Gurung M, 2020, EBIOMEDICINE, V51, DOI 10.1016/j.ebiom.2019.11.051
   Hostalek U, 2015, DRUGS, V75, P1071, DOI 10.1007/s40265-015-0416-8
   Kuang YS, 2016, SCI REP-UK, V6, DOI 10.1038/srep36666
   Liu S, 2019, MICROORGANISMS, V7, DOI 10.3390/microorganisms7060176
   Munoz-Garach A, 2016, ENDOCRINOL NUTR, V63, P560, DOI 10.1016/j.endonu.2016.07.008
   Patel TP, 2016, HEART FAIL REV, V21, P11, DOI 10.1007/s10741-015-9515-6
   Patterson E, 2016, POSTGRAD MED J, V92, P286, DOI 10.1136/postgradmedj-2015-133285
   Ren S M, 2019, Zhonghua Gan Zang Bing Za Zhi, V27, P369, DOI 10.3760/cma.j.issn.1007-3418.2019.05.009
   Rosario D, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.00775
   Sacerdote A, 2019, CURR DIABETES REP, V19, DOI 10.1007/s11892-019-1201-y
   Sanchez-Rangel E, 2017, DIABETOLOGIA, V60, P1586, DOI 10.1007/s00125-017-4336-x
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Vallianou NG, 2019, HORM-INT J ENDOCRINO, V18, P141, DOI 10.1007/s42000-019-00093-w
   Wirth R, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0110440
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Yaribeygi H, 2019, J CELL PHYSIOL, V234, P8152, DOI 10.1002/jcp.27603
   Yuan Y, 2020, BIOMED PHARMACOTHER, V127, DOI 10.1016/j.biopha.2020.110182
NR 29
TC 3
Z9 3
U1 4
U2 8
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1499-2671
EI 2352-3840
J9 CAN J DIABETES
JI Can. J. Diabetes
PD MAR
PY 2022
VL 46
IS 2
BP 150
EP 156
DI 10.1016/j.jcjd.2021.08.001
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 0Z8MZ
UT WOS:000791326900008
PM 35148952
DA 2023-06-08
ER

PT J
AU Forslund, K
   Hildebrand, F
   Nielsen, T
   Falony, G
   Le Chatelier, E
   Sunagawa, S
   Prifti, E
   Vieira-Silva, S
   Gudmundsdottir, V
   Pedersen, HK
   Arumugam, M
   Kristiansen, K
   Voigt, AY
   Vestergaard, H
   Hercog, R
   Costea, PI
   Kultima, JR
   Li, JH
   Jorgensen, T
   Levenez, F
   Dore, J
   Nielsen, HB
   Brunak, S
   Raes, J
   Hansen, T
   Wang, J
   Ehrlich, SD
   Bork, P
   Pedersen, O
AF Forslund, Kristoffer
   Hildebrand, Falk
   Nielsen, Trine
   Falony, Gwen
   Le Chatelier, Emmanuelle
   Sunagawa, Shinichi
   Prifti, Edi
   Vieira-Silva, Sara
   Gudmundsdottir, Valborg
   Pedersen, Helle Krogh
   Arumugam, Manimozhiyan
   Kristiansen, Karsten
   Voigt, Anita Yvonne
   Vestergaard, Henrik
   Hercog, Rajna
   Costea, Paul Igor
   Kultima, Jens Roat
   Li, Junhua
   Jorgensen, Torben
   Levenez, Florence
   Dore, Joel
   Nielsen, H. Bjorn
   Brunak, Soren
   Raes, Jeroen
   Hansen, Torben
   Wang, Jun
   Ehrlich, S. Dusko
   Bork, Peer
   Pedersen, Oluf
CA MetaHIT Consortium
TI Disentangling type 2 diabetes and metformin treatment signatures in the
   human gut microbiota
SO NATURE
LA English
DT Article
ID SP-NOV.; IDENTIFICATION; CLOSTRIDIUM; METAGENOME; GENOMES; HEALTH; COLI;
   LIFE; RAT
AB In recent years, several associations between common chronic human disorders and altered gut microbiome composition and function have been reported(1,2). In most of these reports, treatment regimens were not controlled for and conclusions could thus be confounded by the effects of various drugs on the microbiota, which may obscure microbial causes, protective factors or diagnostically relevant signals. Our study addresses disease and drug signatures in the human gut microbiome of type 2 diabetes mellitus (T2D). Two previous quantitative gut metagenomics studies of T2D patients that were unstratified for treatment yielded divergent conclusions regarding its associated gut microbial dysbiosis(3,4). Here we show, using 784 available human gut metagenomes, how antidiabetic medication confounds these results, and analyse in detail the effects of the most widely used antidiabetic drug metformin. We provide support for microbial mediation of the therapeutic effects of metformin through short-chain fatty acid production, as well as for potential microbiota-mediated mechanisms behind known intestinal adverse effects in the form of a relative increase in abundance of Escherichia species. Controlling for metformin treatment, we report a unified signature of gut microbiome shifts in T2D with a depletion of butyrate-producing taxa(3,4). These in turn cause functional microbiome shifts, in part alleviated by metformin-induced changes. Overall, the present study emphasizes the need to disentangle gut microbiota signatures of specific human diseases from those of medication.
C1 [Forslund, Kristoffer; Hildebrand, Falk; Sunagawa, Shinichi; Voigt, Anita Yvonne; Hercog, Rajna; Costea, Paul Igor; Kultima, Jens Roat; Bork, Peer] European Mol Biol Lab, Struct & Computat Biol Unit, D-69117 Heidelberg, Germany.
   [Hildebrand, Falk; Falony, Gwen; Vieira-Silva, Sara; Raes, Jeroen] Katholieke Univ Leuven, VIB Ctr Biol Dis, B-3000 Leuven, Belgium.
   [Hildebrand, Falk; Raes, Jeroen] Vrije Univ Brussel, Dept Biosci Engn, B-1040 Brussels, Belgium.
   [Nielsen, Trine; Arumugam, Manimozhiyan; Vestergaard, Henrik; Hansen, Torben; Pedersen, Oluf] Univ Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn, Ctr Basic Metab Res, DK-2200 Copenhagen, Denmark.
   [Falony, Gwen; Vieira-Silva, Sara; Raes, Jeroen] Katholieke Univ Leuven, Rega Inst Med Res, Dept Microbiol & Immunol, Lab Mol Bacteriol, B-3000 Leuven, Belgium.
   [Le Chatelier, Emmanuelle; Prifti, Edi; Levenez, Florence; Dore, Joel; Ehrlich, S. Dusko] INRA, MICALIS, F-78352 Jouy En Josas, France.
   [Le Chatelier, Emmanuelle; Prifti, Edi; Levenez, Florence; Dore, Joel; Ehrlich, S. Dusko] INRA, Metagenopolis, F-78352 Jouy En Josas, France.
   [Prifti, Edi] Inst Cardiometab & Nutr, F-75013 Paris, France.
   [Gudmundsdottir, Valborg; Pedersen, Helle Krogh; Nielsen, H. Bjorn; Brunak, Soren] Tech Univ Denmark, Ctr Biol Sequence Anal, Dept Syst Biol, DK-2800 Lyngby, Denmark.
   [Kristiansen, Karsten; Wang, Jun] Univ Copenhagen, Dept Biol, DK-2100 Copenhagen, Denmark.
   [Voigt, Anita Yvonne] Univ Heidelberg Hosp, Inst Pathol, Dept Appl Tumor Biol, D-69120 Heidelberg, Germany.
   [Voigt, Anita Yvonne; Bork, Peer] Heidelberg Univ, Mol Med Partnership Unit, D-69120 Heidelberg, Germany.
   [Voigt, Anita Yvonne; Bork, Peer] European Mol Biol Lab, D-69120 Heidelberg, Germany.
   [Li, Junhua; Wang, Jun] Bejing Genom Inst BGI Shenzhen, Shenzhen 518083, Peoples R China.
   [Jorgensen, Torben] Capital Reg Denmark, Res Ctr Prevent & Hlth, DK-2600 Glostrup, Denmark.
   [Jorgensen, Torben] Univ Copenhagen, Fac Hlth & Med Sci, Dept Publ Hlth, DK-2600 Copenhagen, Denmark.
   [Jorgensen, Torben] Aalborg Univ, Fac Med, DK-9100 Aalborg, Denmark.
   [Brunak, Soren] Univ Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn, Ctr Prot Res,Dis Syst Biol, DK-2200 Copenhagen, Denmark.
   [Hansen, Torben] Univ Southern Denmark, Fac Hlth Sci, DK-5000 Odense, Denmark.
   [Wang, Jun] King Abdulaziz Univ, Princess Al Jawhara Albrahim Ctr Excellence Res H, Jeddah 80205, Saudi Arabia.
   [Wang, Jun] Macau Univ Sci & Technol, Taipa, Macau, Peoples R China.
   [Wang, Jun] Univ Hong Kong, Dept Med, Hong Kong, Hong Kong, Peoples R China.
   [Wang, Jun] Univ Hong Kong, State Key Lab Pharmaceut Biotechnol, Hong Kong, Hong Kong, Peoples R China.
   [Ehrlich, S. Dusko] Kings Coll London, Guys Hosp, Dent Inst Cent Off, Ctr Host Microbiome Interact, London SE1 9RT, England.
   [Bork, Peer] Max Delbruck Ctr Mol Med, D-13125 Berlin, Germany.
   [Bork, Peer] Univ Wurzburg, Dept Bioinformat, D-97074 Wurzburg, Germany.
C3 European Molecular Biology Laboratory (EMBL); Flanders Institute for
   Biotechnology (VIB); KU Leuven; Vrije Universiteit Brussel; Novo Nordisk
   Foundation; University of Copenhagen; KU Leuven; AgroParisTech; INRAE;
   UDICE-French Research Universities; Universite Paris Saclay; INRAE;
   UDICE-French Research Universities; Universite Paris Saclay;
   UDICE-French Research Universities; Sorbonne Universite; Technical
   University of Denmark; University of Copenhagen; Ruprecht Karls
   University Heidelberg; Ruprecht Karls University Heidelberg; European
   Molecular Biology Laboratory (EMBL); Beijing Genomics Institute (BGI);
   University of Copenhagen; Aalborg University; Novo Nordisk Foundation;
   University of Copenhagen; University of Southern Denmark; King Abdulaziz
   University; Macau University of Science & Technology; University of Hong
   Kong; University of Hong Kong; Guy's & St Thomas' NHS Foundation Trust;
   University of London; King's College London; Helmholtz Association; Max
   Delbruck Center for Molecular Medicine; University of Wurzburg
RP Ehrlich, SD (通讯作者)，INRA, MICALIS, F-78352 Jouy En Josas, France.
EM dusko.ehrlich@jouy.inra.fr; bork@embl.de; oluf@sund.ku.dk
RI Knol, Jan/A-2178-2010; Guarner, Francisco/ABF-1192-2020; Tap,
   Julien/E-5760-2010; Forslund, Sofia K/Y-2393-2019; LE CHATELIER,
   Emmanuelle/O-1243-2017; Pedersen, Oluf/Z-1731-2019; Falony,
   Gwen/AAN-5011-2020; Nielsen, Henrik Bjørn/B-8961-2019; Bork,
   Peer/F-1813-2013; Arumugam, Manimozhiyan/AAJ-2394-2020; LI,
   Junhua/AAG-3919-2019; Borruel, Natalia/AFO-6891-2022; raes,
   jeroen/D-7835-2018; Dore, Joel/ABA-8921-2020; Prifti, Edi/F-3967-2019;
   GUEDON, Eric/N-8624-2019; Arumugam, Manimozhiyan/E-1211-2011; Guedon,
   Eric/S-5635-2016; Vieira-Silva, Sara/ABE-1247-2021; Sunagawa,
   Shinichi/Q-5950-2019; Vieira-Silva, Sara/HLH-1768-2023; Ehrlich,
   S./Y-2423-2019; Kristiansen, Karsten/J-5148-2014; Ho, Igor
   Osorio/AAG-8616-2020; Knol, Jan/AAL-6487-2020; Nielsen,
   trine/HJZ-4867-2023; Hildebrand, Falk/K-1914-2014; Jørgensen,
   Torben/Z-1335-2018; Pedersen, Oluf/AAG-8015-2020; BLOTTIERE, Hervé
   M/C-6120-2011; Sicheritz-Ponten, Thomas/A-4325-2017; Brunak,
   Soren/O-6621-2016; Dore, Joel/I-1799-2014
OI Knol, Jan/0000-0002-2103-5961; Guarner, Francisco/0000-0002-4051-0836;
   Tap, Julien/0000-0001-8998-5413; LE CHATELIER,
   Emmanuelle/0000-0002-2724-0536; Pedersen, Oluf/0000-0002-3321-3972;
   Falony, Gwen/0000-0003-2450-0782; Nielsen, Henrik
   Bjørn/0000-0003-2281-5713; Bork, Peer/0000-0002-2627-833X; Arumugam,
   Manimozhiyan/0000-0002-0886-9101; LI, Junhua/0000-0001-6784-1873;
   Borruel, Natalia/0000-0002-4449-2292; raes, jeroen/0000-0002-1337-041X;
   Prifti, Edi/0000-0001-8861-1305; GUEDON, Eric/0000-0002-0901-4447;
   Arumugam, Manimozhiyan/0000-0002-0886-9101; Guedon,
   Eric/0000-0002-0901-4447; Vieira-Silva, Sara/0000-0002-4616-7602;
   Sunagawa, Shinichi/0000-0003-3065-0314; Vieira-Silva,
   Sara/0000-0002-4616-7602; Ehrlich, S./0000-0002-7563-4046; Kristiansen,
   Karsten/0000-0002-6024-0917; Knol, Jan/0000-0002-2103-5961; Nielsen,
   trine/0000-0002-2066-7895; Hildebrand, Falk/0000-0002-0078-8948;
   BLOTTIERE, Hervé M/0000-0002-8390-0607; Chaysavanh,
   Manichanh/0000-0002-2287-4003; Hansen, Torben/0000-0001-8748-3831;
   Pelletier, Eric/0000-0003-4228-1712; Forslund, Sofia
   K/0000-0003-4285-6993; Varela Castro, Encarna/0000-0001-6334-9320;
   Costea, Paul Igor/0000-0003-1645-3947; Voigt, Anita
   Yvonne/0000-0002-6794-0385; Sicheritz-Ponten,
   Thomas/0000-0001-6615-1141; Gudmundsdottir, Valborg/0000-0002-7459-1603;
   Brunak, Soren/0000-0003-0316-5866; Burgdorf,
   Kristoffer/0000-0001-5814-6844; Vestergaard, Henrik/0000-0003-3090-269X;
   Jorgensen, Torben/0000-0001-9453-2830; Pedersen, Helle
   Krogh/0000-0001-9609-7377; Derrien, Muriel/0000-0001-8841-9153; Dore,
   Joel/0000-0002-8756-0718
FU European Community [HEALTH-F4-2007-201052, HEALTH-2012-305312,
   HEALTH-2010-261376]; Metagenopolis grant [ANR-11-DPBS-0001]; European
   Research Council [268985]; European Union [600375]; Lundbeck Foundation
   Centre for Applied Medical Genomics in Personalized Disease Prediction,
   Prevention and Care (LuCamp); Novo Nordisk Foundation [NNF14CC0001];
   European Molecular Biology Laboratory (EMBL); Novo Nordisk Foundation;
   Innovation Fund Denmark through the MicrobDiab project
FX The authors wish to thank A. Forman, T. Lorentzen, B. Andreasen, G. J.
   Klavsen and M. J. Nielsen for technical assistance, and T. F. Toldsted
   and G. Lademann for management assistance. J. Nielsen and F. Backhed are
   thanked for providing access to T2D metagenome data and metformin
   treatment status before publication<SUP>4</SUP>. V. Benes and the
   GeneCore facility of EMBL Heidelberg are thanked for their assistance
   with the metformin signature validation experiments, as is Y. Yuan for
   assistance with computer infrastructure. This research has received
   funding from European Community's Seventh Framework Program
   (FP7/2007-2013): MetaHIT, grant agreement HEALTH-F4-2007-201052,
   MetaCardis, grant agreement HEALTH-2012-305312, International Human
   Microbiome Standards, grant agreement HEALTH-2010-261376, as well as
   from the Metagenopolis grant ANR-11-DPBS-0001, from the European
   Research Council CancerBiome project, contract number 268985, and from
   the European Union HORIZON 2020 programme, under Marie Sklodowska-Curie
   grant agreement 600375. Additional funding came from The Lundbeck
   Foundation Centre for Applied Medical Genomics in Personalized Disease
   Prediction, Prevention and Care (LuCamp, http://www.lucamp.org), the
   Novo Nordisk Foundation (grant NNF14CC0001), and the European Molecular
   Biology Laboratory (EMBL). The Novo Nordisk Foundation Center for Basic
   Metabolic Research is an independent Research Center at the University
   of Copenhagen partially funded by an unrestricted donation from the Novo
   Nordisk Foundation (http://www.metabol.ku.dk). Additional funding for
   the validation experiments was provided by the Innovation Fund Denmark
   through the MicrobDiab project.
CR Abeel T, 2009, BIOINFORMATICS, V25, pI313, DOI 10.1093/bioinformatics/btp191
   Anderson MJ, 2001, AUSTRAL ECOL, V26, P32, DOI 10.1046/j.1442-9993.2001.01070.x
   Arumugam M, 2010, BIOINFORMATICS, V26, P2977, DOI 10.1093/bioinformatics/btq536
   BENJAMINI Y, 1995, J R STAT SOC B, V57, P289, DOI 10.1111/j.2517-6161.1995.tb02031.x
   Biltoft-Jensen A., 2005, DFVF PUBLICATION, V11
   Cabreiro F, 2013, CELL, V153, P228, DOI 10.1016/j.cell.2013.02.035
   Cho I, 2012, NAT REV GENET, V13, P260, DOI 10.1038/nrg3182
   Croset M, 2001, DIABETES, V50, P740, DOI 10.2337/diabetes.50.4.740
   CZYZYK A, 1968, DIABETES, V17, P492, DOI 10.2337/diab.17.8.492
   De Vadder F, 2014, CELL, V156, P84, DOI 10.1016/j.cell.2013.12.016
   de Vos WM, 2013, NATURE, V498, P48, DOI 10.1038/nature12251
   Dixon P, 2003, J VEG SCI, V14, P927, DOI 10.1111/j.1654-1103.2003.tb02228.x
   Edgar RC, 2013, NAT METHODS, V10, P996, DOI [10.1038/nmeth.2604, 10.1038/NMETH.2604]
   Edgar RC, 2011, BIOINFORMATICS, V27, P2194, DOI 10.1093/bioinformatics/btr381
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Friedman J, 2010, J STAT SOFTW, V33, P1, DOI 10.18637/jss.v033.i01
   Gerritsen J, 2014, INT J SYST EVOL MICR, V64, P1600, DOI 10.1099/ijs.0.059543-0
   Haraldsdottir J., 1998, PORTIONSSTORLEKER NO
   Hildebrand F, 2014, MICROBIOME, V2, DOI 10.1186/2049-2618-2-30
   Hildebrand F, 2013, GENOME BIOL, V14, DOI 10.1186/gb-2013-14-1-r4
   Hildebrand F, 2012, BMC GENOMICS, V13, DOI 10.1186/1471-2164-13-514
   Hothorn T, 2006, AM STAT, V60, P257, DOI 10.1198/000313006X118430
   Jorgensen Torben, 2003, Eur J Cardiovasc Prev Rehabil, V10, P377
   Kanehisa M, 2008, NUCLEIC ACIDS RES, V36, pD480, DOI 10.1093/nar/gkm882
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kultima JR, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0047656
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Le Chatelier E, 2013, NATURE, V500, P541, DOI 10.1038/nature12506
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Li JH, 2014, NAT BIOTECHNOL, V32, P834, DOI 10.1038/nbt.2942
   Li WZ, 2006, BIOINFORMATICS, V22, P1658, DOI 10.1093/bioinformatics/btl158
   Madden T., 2002, NCBI HDB, V2nd
   Magoc T, 2011, BIOINFORMATICS, V27, P2957, DOI 10.1093/bioinformatics/btr507
   Messori S, 2013, VET MICROBIOL, V162, P173, DOI 10.1016/j.vetmic.2012.09.001
   Moller A., 2002, FODEVAREDATABANKEN V
   Napolitano A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100778
   Nielsen HB, 2014, NAT BIOTECHNOL, V32, P822, DOI 10.1038/nbt.2939
   Organization WH, 1999, DEF DIAGN CLASS DI 1, DOI DOI 10.1002/(SICI)1096-9136(199807)15:7
   Pernicova I, 2014, NAT REV ENDOCRINOL, V10, P143, DOI 10.1038/nrendo.2013.256
   Powell S, 2012, NUCLEIC ACIDS RES, V40, pD284, DOI 10.1093/nar/gkr1060
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Quast Christian, 2013, Nucleic Acids Res, V41, pD590, DOI 10.1093/nar/gks1219
   Sato J, 2014, DIABETES CARE, V37, P2343, DOI 10.2337/dc13-2817
   Schellenberg ES, 2013, ANN INTERN MED, V159, P543, DOI 10.7326/0003-4819-159-8-201310150-00007
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Shreiner AB, 2015, CURR OPIN GASTROEN, V31, P69, DOI 10.1097/MOG.0000000000000139
   Song YL, 2004, ANAEROBE, V10, P179, DOI 10.1016/j.anaerobe.2004.04.004
   Sunagawa S, 2015, SCIENCE, V348, DOI 10.1126/science.1261359
   Sunagawa S, 2013, NAT METHODS, V10, P1196, DOI [10.1038/nmeth.2693, 10.1038/NMETH.2693]
   Wickham H, 2009, USE R, P1, DOI 10.1007/978-0-387-98141-3
   Winter SE, 2013, SCIENCE, V339, P708, DOI 10.1126/science.1232467
   Zhang XY, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0071108
NR 52
TC 1219
Z9 1289
U1 24
U2 614
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 0028-0836
EI 1476-4687
J9 NATURE
JI Nature
PD DEC 10
PY 2015
VL 528
IS 7581
BP 262
EP +
DI 10.1038/nature15766
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA CX9VH
UT WOS:000366053300041
PM 26633628
OA Green Submitted, Green Accepted
HC Y
HP N
DA 2023-06-08
ER

PT J
AU Zhang, Q
   Hu, N
AF Zhang, Qi
   Hu, Nan
TI Effects of Metformin on the Gut Microbiota in Obesity and Type 2
   Diabetes Mellitus
SO DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
LA English
DT Review
DE metformin; gut microbiota; obesity; type 2 diabetes mellitus
ID DIET-INDUCED OBESITY; BILE-ACIDS; CLOSTRIDIUM-DIFFICILE; METABOLIC
   BENEFITS; GLUCOSE; INFLAMMATION; ASSOCIATION; ENDOTOXEMIA; METAGENOME;
   RESISTANCE
AB Metformin is a first-line treatment for type 2 diabetes mellitus (T2DM); however, its underlying mechanism is not fully understood. Gut microbiota affect the development and progression of T2DM. In recent years, an increasing number of studies has focused on the relationship between metformin and gut microbiota, suggesting that metformin might exert part of its hypoglycemic effect through these microbes. However, most of these results were not consistent due to the complex composition of the microbiota, the differences between species, the large variation between individuals, and the differences in experimental design, bringing great obstacle for our better understanding of the effects of metformin on the gut microbiota. Here, we reviewed the published papers concerning about the impacts of metformin on the gut microbiota of mice, rats, and humans with obesity or T2DM, and summarized the changes of gut microbiota composition caused by metformin and the possible underlying hypoglycemic mechanism which is related to gut microbiota. It was found that the proportions of some microbiota, such as phyla Bacteroidetes and Verrucomicrobia and genera Akketmansia, Bacteroides and Escherichia, were significantly affected by metformin in several studies. Metformin may exert part of hypoglycemic effects by altering the gut microbiota in ways that maintain the integrity of the intestinal barrier, promote the production of short-chain fatty acids (SCFAs), regulate bile acid metabolism, and improve glucose homeostasis.
C1 [Zhang, Qi] Changzhou 7 Peoples Hosp, Dept Pharm, Changzhou 213000, Jiangsu, Peoples R China.
   [Hu, Nan] Soochow Univ, Affiliated Hosp 3, Dept Pharm, Changzhou 213000, Jiangsu, Peoples R China.
C3 Soochow University - China
RP Hu, N (通讯作者)，Soochow Univ, Affiliated Hosp 3, Dept Pharm, Changzhou 213000, Jiangsu, Peoples R China.
EM hn_324@163.com
FU National Science Foundation of China [81503136]; Changzhou High-Level
   Medical Talents Training Project [2016CZBJ010]
FX This study was funded by the National Science Foundation of China (No:
   81503136) and the Changzhou High-Level Medical Talents Training Project
   (No: 2016CZBJ010).
CR Ahmad A, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0226372
   Ahmadi S, 2020, J GERONTOL A-BIOL, V75, pE9, DOI 10.1093/gerona/glaa056
   Backhed F, 2012, NUTR REV, V70, pS14, DOI 10.1111/j.1753-4887.2012.00496.x
   Barengolts E, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0194171
   Bauer PV, 2018, CELL METAB, V27, P101, DOI 10.1016/j.cmet.2017.09.019
   Bibbo S, 2016, EUR REV MED PHARMACO, V20, P4742
   Bornstein S, 2017, ENDOCRINOLOGY, V158, P3369, DOI 10.1210/en.2017-00299
   Brandt A, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-43228-0
   Bryrup T, 2019, DIABETOLOGIA, V62, P1024, DOI 10.1007/s00125-019-4848-7
   Burcelin R, 2011, ACTA DIABETOL, V48, P257, DOI 10.1007/s00592-011-0333-6
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Cani PD, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.01765
   Cani PD, 2012, GUT MICROBES, V3, P279, DOI 10.4161/gmic.19625
   Carter D, 2003, DIABETES OBES METAB, V5, P120, DOI 10.1046/j.1463-1326.2003.00252.x
   Caspard H, 2018, DIABETES OBES METAB, V20, P667, DOI 10.1111/dom.13143
   Chandel NS, 2016, CELL METAB, V23, P569, DOI 10.1016/j.cmet.2016.03.010
   Chavez-Carbajal A, 2020, MICROORGANISMS, V8, DOI 10.3390/microorganisms8010094
   Chen C, 2018, FOOD FUNCT, V9, P3732, DOI [10.1039/C7FO01346A, 10.1039/c7fo01346a]
   Chen LC, 2019, FOOD FUNCT, V10, P4372, DOI [10.1039/C9FO00406H, 10.1039/c9fo00406h]
   Chung E, 2020, NUTR RES, V77, P97, DOI 10.1016/j.nutres.2020.04.001
   Coughlan KA, 2014, DIABET METAB SYND OB, V7, P241, DOI 10.2147/DMSO.S43731
   Cui HX, 2019, FRONT MICROBIOL, V10, DOI 10.3389/fmicb.2019.01423
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   De Vadder F, 2014, CELL, V156, P84, DOI 10.1016/j.cell.2013.12.016
   Delzenne NM, 2015, DIABETOLOGIA, V58, P2206, DOI 10.1007/s00125-015-3712-7
   [邓冠华 Deng Guanhua], 2014, [生态科学, Ecologic Science], V33, P851
   Ejtahed HS, 2019, EUR J ENDOCRINOL, V180, P165, DOI [10.1530/EJE-18-0826, 10.1530/eje-18-0826]
   Elbere I, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0204317
   Fava S, 2014, CURR DIABETES REV, V10, P302, DOI 10.2174/1573399810666141030125830
   Foretz M, 2010, J CLIN INVEST, V120, P2355, DOI 10.1172/JCI40671
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Gao K, 2018, PHARMACOL RES, V130, P93, DOI 10.1016/j.phrs.2018.01.011
   Hiel S, 2020, CLIN NUTR, V39, P3618, DOI 10.1016/j.clnu.2020.04.005
   Horakova O, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-42531-0
   Huang F, 2018, INT J FOOD SCI NUTR, V69, P729, DOI 10.1080/09637486.2017.1408059
   Ji SQ, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00704
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Khat-udomkiri N, 2020, FOOD SCI NUTR, V8, P428, DOI 10.1002/fsn3.1327
   Koh A, 2016, CELL, V165, P1332, DOI 10.1016/j.cell.2016.05.041
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Lee H, 2018, GERONTOLOGIST, V58, P159, DOI 10.1093/geront/gnx050
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Ley RE, 2008, SCIENCE, V320, P1647, DOI 10.1126/science.1155725
   Li QZ, 2020, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00939
   Liu GM, 2018, INT J BIOL MACROMOL, V115, P711, DOI 10.1016/j.ijbiomac.2018.04.127
   Liu GM, 2018, MOL NUTR FOOD RES, V62, DOI 10.1002/mnfr.201700954
   Liu YY, 2020, FASEB J, V34, P1065, DOI 10.1096/fj.201901943RR
   Ma W, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.01336
   Morita Y, 2020, DIABETES CARE, V43, P1796, DOI 10.2337/dc20-0093
   Napolitano A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100778
   Pavlidis P, 2015, ALIMENT PHARM THER, V42, P802, DOI 10.1111/apt.13333
   Pearson ER, 2019, DIABETOLOGIA, V62, P1107, DOI 10.1007/s00125-019-4909-y
   Peng WJ, 2020, FRONT MICROBIOL, V10, DOI 10.3389/fmicb.2019.03141
   Pollak M, 2017, DIABETOLOGIA, V60, P1662, DOI 10.1007/s00125-017-4352-x
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Ridlon JM, 2016, GUT MICROBES, V7, P22, DOI 10.1080/19490976.2015.1127483
   Ryan PM, 2020, CAN J DIABETES, V44, P146, DOI 10.1016/j.jcjd.2019.05.008
   Ryan PM, 2017, DIABETOL METAB SYNDR, V9, DOI 10.1186/s13098-017-0299-9
   Sedighi M, 2017, MICROB PATHOGENESIS, V111, P362, DOI 10.1016/j.micpath.2017.08.038
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Sonne DP, 2016, J CLIN ENDOCR METAB, V101, P3002, DOI 10.1210/jc.2016-1607
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Wang JH, 2017, BMJ OPEN DIAB RES CA, V8
   Wang JH, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00620
   Weingarden AR, 2016, J CLIN GASTROENTEROL, V50, P624, DOI 10.1097/MCG.0000000000000427
   Winston JA, 2016, ANAEROBE, V41, P44, DOI 10.1016/j.anaerobe.2016.05.003
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Yang XiaoQing, 2011, Zhongguo Weishengtaxixue Zazhi / Chinese Journal of Microecology, V23, P134
   Zhang F, 2019, LIFE SCI, V229, P80, DOI 10.1016/j.lfs.2019.05.031
   Zhang FH, 2019, ENDOCRINE, V66, P485, DOI 10.1007/s12020-019-02041-5
   Zhang W, 2019, BIOMED PHARMACOTHER, V118, DOI 10.1016/j.biopha.2019.109131
   Zhang XY, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0071108
   Zhang XQ, 2015, SCI REP-UK, V5, DOI 10.1038/srep10737
   Zheng JL, 2018, J AGR FOOD CHEM, V66, P5821, DOI [10.1021/acsjafc.8b00829, 10.1021/acs.jafc.8b00829]
   Zhou ZY, 2016, ACTA PHARMACOL SIN, V37, P1063, DOI 10.1038/aps.2016.21
NR 75
TC 56
Z9 56
U1 7
U2 35
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7007
J9 DIABET METAB SYND OB
JI Diabetes Metab. Syndr. Obes.
PY 2020
VL 13
BP 5003
EP 5014
DI 10.2147/DMSO.S286430
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA PH8LU
UT WOS:000600657700007
PM 33364804
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Zhang, FH
   Wang, M
   Yang, JJ
   Xu, Q
   Liang, C
   Chen, B
   Zhang, JM
   Yang, Y
   Wang, HL
   Shang, YF
   Wang, Y
   Mu, XF
   Zhu, DQ
   Zhang, CL
   Yao, MX
   Zhang, L
AF Zhang, Fanghua
   Wang, Meng
   Yang, Junjie
   Xu, Qian
   Liang, Cheng
   Chen, Bin
   Zhang, Jiaming
   Yang, Ying
   Wang, Huiling
   Shang, Yongfang
   Wang, Ye
   Mu, Xiaofeng
   Zhu, Dequan
   Zhang, Chunling
   Yao, Minxiu
   Zhang, Lei
TI Response of gut microbiota in type 2 diabetes to hypoglycemic agents
SO ENDOCRINE
LA English
DT Article
DE Microbiota; Type 2 diabetes; Metformin; Insulin; alpha-Glucosidase
   inhibitors
ID INFLAMMATION; PREVALENCE; IMPACT; DIET
AB Purpose Accumulated evidence has indicated that the gut microbiome affected the pharmacology of anti-diabetic agents, and their metabolic products induced by the agents transformed the structure of gastrointestinal microbiota in return. However, the studies around heredity, ethnicity, or living condition, referring to human microbiome were mostly represented by an occidental pattern partial and rare studies that focused on the effect of several first-line hypoglycemic agents on the gut flora in a single medical center. Therefore, we aimed to explore the interaction between gut microbiome and type 2 diabetes (T2D) or hypoglycemics in Chinese population.
   Methods A total of 130 T2D patients with a specific hypoglycemic treatment and 50 healthy volunteers were enrolled in this study. Gut microbiome compositons were analyzed by 16S ribosomal RNA gene-based sequencing protocol.
   Results Hypoglycemic agents contributed to the alteration of specific species in gut bacteria rather than its total diversity. Metformin increased the abundance of Spirochaete, Turicibacter, and Fusobacterium. Insulin also increased Fusobacterium, and alpha-glucosidase inhibitors (alpha-GIs) contributed to the plentitude of Bifidobacterium and Lactobacillus. Both metformin and insulin improved taurine and hypotaurine metabolism, and alpha-GI promoted several amino acid pathways. Although the community of gut microbiota with metformin and insulin showed similarity, significant differences were available in each diabetic group with hypoglycemia.
   Conclusions Gut microbiota is significantly associated with anti-diabetic agents. The gut microbiome and metabolism have shown respective characteristics in different T2D groups, which were also significantly different from the healthy group. This study provides some new insights for identification and exploration of the pathogenesis of T2D.
C1 [Zhang, Fanghua; Xu, Qian; Yang, Ying; Wang, Huiling; Shang, Yongfang; Yao, Minxiu] Qingdao Univ, Affiliated Cent Hosp, Dept Endocrinol, Qingdao, Shandong, Peoples R China.
   [Zhang, Fanghua; Wang, Ye; Mu, Xiaofeng; Zhang, Chunling; Yao, Minxiu] Qingdao Univ, Affiliated Cent Hosp, Qingdao Human Microbiome Ctr, Qingdao, Shandong, Peoples R China.
   [Wang, Meng] Ocean Univ China, Coll Marine Life Sci, Qingdao, Shandong, Peoples R China.
   [Yang, Junjie] Qilu Normal Univ, Coll Life Sci, Jinan, Shandong, Peoples R China.
   [Yang, Junjie] Shandong Univ, Shandong Childrens Microbiome Ctr, Qilu Childrens Hosp, Jinan 250022, Shandong, Peoples R China.
   [Liang, Cheng] Shandong Normal Univ, Sch Informat Sci & Engn, Jinan, Shandong, Peoples R China.
   [Chen, Bin; Zhang, Lei] Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Beijing, Peoples R China.
   [Zhang, Jiaming] Shandong Inst Food & Drug Control, Jinan, Shandong, Peoples R China.
   [Wang, Ye; Mu, Xiaofeng] Qingdao Univ, Cent Hosp, Clin Lab & Core Res Lab, Qingdao, Shandong, Peoples R China.
   [Zhu, Dequan] Lin Yi Peoples Hosp, Microbiol Lab, Linyi, Shandong, Peoples R China.
C3 Qingdao University; Qingdao University; Ocean University of China; Qilu
   Normal University; Shandong University; Shandong Normal University;
   Beihang University; Qingdao University
RP Yao, MX (通讯作者)，Qingdao Univ, Affiliated Cent Hosp, Dept Endocrinol, Qingdao, Shandong, Peoples R China.; Yao, MX (通讯作者)，Qingdao Univ, Affiliated Cent Hosp, Qingdao Human Microbiome Ctr, Qingdao, Shandong, Peoples R China.; Zhang, L (通讯作者)，Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Beijing, Peoples R China.
EM yaominxiu@medmail.com.cn; microbiome@foxmail.com
RI junjie, Yang/AAD-6699-2019; Zhang, Fang/HHN-2153-2022
FU National Natural Science Foundation of China [31471202, 81670822];
   Shandong Provincial Key Research and Development Program [2016YYSP009];
   Weihai Technique Extension Project [2016GNS023]; Qingdao Key Research
   Project [17-3-3-10nsh]; Taishan Scholars Program of Shandong Province
   [tshw20120206]
FX This project has been supported by the National Natural Science
   Foundation of China under contract no. 31471202 (to L.Z.) and no.
   81670822 (to Y.W.); the Shandong Provincial Key Research and Development
   Program under contract no. 2016YYSP009 (to L. Z.); Weihai Technique
   Extension Project under contract no. 2016GNS023 (to L.Z.); Qingdao Key
   Research Project No. 17-3-3-10nsh (to C.Z.). L.Z. is also supported by
   the Taishan Scholars Program of Shandong Province (no. tshw20120206).
CR [Anonymous], LANCET
   [Anonymous], GASTROENTEROLOGY
   [Anonymous], NAT PUBL GROUP
   Brahe LK, 2013, OBES REV, V14, P950, DOI 10.1111/obr.12068
   Buse JB, 2016, DIABETES CARE, V39, P198, DOI 10.2337/dc15-0488
   Caporaso JG, 2010, NAT METHODS, V7, P335, DOI 10.1038/nmeth.f.303
   Chen L, 2017, NAT IMMUNOL, V18, P541, DOI 10.1038/ni.3690
   Cole JR, 2009, NUCLEIC ACIDS RES, V37, pD141, DOI 10.1093/nar/gkn879
   Geva-Zatorsky N, 2017, CELL, V168, P928, DOI 10.1016/j.cell.2017.01.022
   Gevers D, 2014, CELL HOST MICROBE, V15, P382, DOI 10.1016/j.chom.2014.02.005
   Greiner T, 2011, TRENDS ENDOCRIN MET, V22, P117, DOI 10.1016/j.tem.2011.01.002
   Gu YY, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-01682-2
   Gupta VK, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.01162
   Henao-Mejia J, 2012, NATURE, V482, P179, DOI 10.1038/nature10809
   Herrema H, 2017, DIABETOLOGIA, V60, P613, DOI 10.1007/s00125-016-4192-0
   Human Microbiome Project Consortium, 2012, Nature, V486, P207, DOI 10.1038/nature11234
   Jiang R, 2004, JAMA-J AM MED ASSOC, V291, P711, DOI 10.1001/jama.291.6.711
   Jung MJ, 2016, SCI REP-UK, V6, DOI 10.1038/srep30887
   Kishida Y, 2017, J GASTROENTEROL, V52, P1180, DOI 10.1007/s00535-017-1331-4
   Koropatkin NM, 2017, CELL METAB, V26, P456, DOI 10.1016/j.cmet.2017.08.022
   Langille MGI, 2013, NAT BIOTECHNOL, V31, P814, DOI 10.1038/nbt.2676
   Ma RCW, 2014, LANCET DIABETES ENDO, V2, P980, DOI 10.1016/S2213-8587(14)70145-7
   Machiels K, 2014, GUT, V63, P1275, DOI 10.1136/gutjnl-2013-304833
   Magoc T, 2011, BIOINFORMATICS, V27, P2957, DOI 10.1093/bioinformatics/btr507
   Pedersen HK, 2016, NATURE, V535, P376, DOI 10.1038/nature18646
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Sarangi AN, 2017, BMC GASTROENTEROL, V17, DOI 10.1186/s12876-017-0683-9
   Shao TJ, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.00268
   Su BL, 2015, J DIABETES, V7, P729, DOI 10.1111/1753-0407.12232
   Tan TG, 2016, P NATL ACAD SCI USA, V113, pE8141, DOI 10.1073/pnas.1617460113
   Tanca A, 2017, MICROBIOME, V5, DOI 10.1186/s40168-017-0293-3
   Turroni F, 2016, ISME J, V10, P1656, DOI 10.1038/ismej.2015.236
   Vazquez-Baeza Y, 2018, ANNU REV PHARMACOL, V58, P253, DOI 10.1146/annurev-pharmtox-042017-031849
   Wang LM, 2017, JAMA-J AM MED ASSOC, V317, P2515, DOI 10.1001/jama.2017.7596
   Wellen KE, 2005, J CLIN INVEST, V115, P1111, DOI 10.1172/JCI200525102
   Winiarska K, 2009, BIOCHIMIE, V91, P261, DOI 10.1016/j.biochi.2008.09.006
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Xu Y, 2013, JAMA-J AM MED ASSOC, V310, P948, DOI 10.1001/jama.2013.168118
NR 38
TC 38
Z9 41
U1 5
U2 44
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1355-008X
EI 1559-0100
J9 ENDOCRINE
JI Endocrine
PD DEC
PY 2019
VL 66
IS 3
BP 485
EP 493
DI 10.1007/s12020-019-02041-5
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA JY1UP
UT WOS:000504207800007
PM 31410749
DA 2023-06-08
ER

PT J
AU Hao, ZK
   Li, LY
   Ning, ZB
   Zhang, X
   Mayne, J
   Cheng, K
   Walker, K
   Liu, H
   Figeys, D
AF Hao, Zikai
   Li, Leyuan
   Ning, Zhibin
   Zhang, Xu
   Mayne, Janice
   Cheng, Kai
   Walker, Krystal
   Liu, Hong
   Figeys, Daniel
TI Metaproteomics Reveals Growth Phase-Dependent Responses of an In Vitro
   Gut Microbiota to Metformin
SO JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
LA English
DT Article
DE metaproteomics; gut microbiota; in vitro culturing; growth phase; drug
   response; metformin
ID ESCHERICHIA-COLI; BACTEROIDES; METABOLISM; SIMULATOR
AB Metaproteomics has been used in combination with in vitro gut microbiota models to study drug-microbiome interactions. However, it remains unexplored whether the metaproteomics profile of in vitro gut microbiota responds differently to a same stimulus added at different growth phases. In this study, we cultured a human gut microbiota in 96-deep well plates using a previously validated model. Metformin was added during the lag, log, and stationary phases. Microbiome samples, collected at different time points, were analyzed by optical density and function by metaproteomic. The in vitro gut microbiota growth curves, taxonomy, and functional responses were different depending whether metformin was added during the lag, log, or stationary phases. The addition of drugs at the log phase may lead to the greatest decline of bacterial growth. Metaproteomic analysis suggests that the strength of the metformin effect on the gut microbiome functional profile may be ranked as lag phase > log phase > stationary phase. Metformin added at the lag phase may result in a significantly reduced level of the Clostridiales order and an increased level of the Bacteroides genus, which is different from stimulations during the rest of the growth phases. Metformin may also result in alterations of several pathways, including energy production and conversion, lipid transport and metabolism, translation, ribosomal structure, and biogenesis. Our results indicate that the timing for drug stimulation should be considered when studying drug-microbiome interactions in vitro.
C1 [Hao, Zikai; Liu, Hong; Figeys, Daniel] Beihang Univ, Beijing Adv Innovat Ctr Biomed Engn, Beijing 100083, Peoples R China.
   [Hao, Zikai; Liu, Hong] Beihang Univ, Sch Biol Sci & Med Engn, Beijing 100083, Peoples R China.
   [Hao, Zikai; Li, Leyuan; Ning, Zhibin; Zhang, Xu; Mayne, Janice; Cheng, Kai; Walker, Krystal; Figeys, Daniel] Univ Ottawa, Fac Med, Ottawa Inst Syst Biol, Dept Biochem Microbiol & Immunol, Ottawa, ON K1H 8M5, Canada.
C3 Beihang University; Beihang University; University of Ottawa
RP Liu, H; Figeys, D (通讯作者)，Beihang Univ, Beijing Adv Innovat Ctr Biomed Engn, Beijing 100083, Peoples R China.; Liu, H (通讯作者)，Beihang Univ, Sch Biol Sci & Med Engn, Beijing 100083, Peoples R China.; Figeys, D (通讯作者)，Univ Ottawa, Fac Med, Ottawa Inst Syst Biol, Dept Biochem Microbiol & Immunol, Ottawa, ON K1H 8M5, Canada.
EM lh64@buaa.edu.cn; dfigeys@uottawa.ca
RI Hao, Zikai/CAG-2251-2022
OI Figeys, Daniel/0000-0002-5373-7546; Zhang, Xu/0000-0003-2406-9478
FU Government of Canada through Genome Canada; Ontario Genomics Institute
   [OGI-156]; Natural Sciences and Engineering Research Council of Canada
   (NSERC) [210034]; Ontario Ministry of Economic Development and
   Innovation [ORF-DIG-14405]; National Natural Science Foundation of China
   [81871520]; China Scholarship Council (CSC)
FX This work was supported by the Government of Canada through Genome
   Canada and the Ontario Genomics Institute (OGI-156), the Natural
   Sciences and Engineering Research Council of Canada (NSERC, Grant No.
   210034), the Ontario Ministry of Economic Development and Innovation
   (ORF-DIG-14405), and the National Natural Science Foundation of China
   (81871520). Z.H. was funded by a scholarship from the China Scholarship
   Council (CSC). L.L. was funded by a stipend from the NSERC CREATE in
   Technologies for Microbiome Science and Engineering (TECHNOMISE)
   Program.
CR [Anonymous], NAT BIOTECHNOL, V32, P834
   Bridges BA, 2001, MUTAT RES-FUND MOL M, V473, P109, DOI 10.1016/S0027-5107(00)00144-5
   Bryrup T, 2019, DIABETOLOGIA, V62, P1024, DOI 10.1007/s00125-019-4848-7
   Cani PD, 2011, PHARMACOL THERAPEUT, V130, P202, DOI 10.1016/j.pharmthera.2011.01.012
   Cheng K, 2017, MICROBIOME, V5, DOI 10.1186/s40168-017-0375-2
   Chong Jasmine, 2019, Curr Protoc Bioinformatics, V68, pe86, DOI 10.1002/cpbi.86
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Funke B. R., 1998, MICROBIOLOGY INTRO
   Giuliani C, 2016, FOOD FUNCT, V7, P4564, DOI [10.1039/C6FO00784H, 10.1039/c6fo00784h]
   Guo HH, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-09852-0
   Hobby GL, 1944, P SOC EXP BIOL MED, V56, P181, DOI 10.3181/00379727-56-14643
   Hobby GL, 1942, P SOC EXP BIOL MED, V50, P281, DOI 10.3181/00379727-50-13773
   Imhann F, 2017, GUT MICROBES, V8, P351, DOI 10.1080/19490976.2017.1284732
   Jalili-Firoozinezhad S, 2019, NAT BIOMED ENG, V3, P520, DOI 10.1038/s41551-019-0397-0
   Kim HJ, 2016, P NATL ACAD SCI USA, V113, pE7, DOI 10.1073/pnas.1522193112
   Lam KN, 2019, CELL HOST MICROBE, V26, P22, DOI 10.1016/j.chom.2019.06.011
   Lee H, 2018, GERONTOLOGIST, V58, P159, DOI 10.1093/geront/gnx050
   Li LT, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-09096-y
   Liao B, 2018, BIOINFORMATICS, V34, P3954, DOI 10.1093/bioinformatics/bty466
   Liu XJ, 2016, CELL METAB, V24, P728, DOI 10.1016/j.cmet.2016.09.005
   Macedo MH, 2018, TRENDS MOL MED, V24, P696, DOI 10.1016/j.molmed.2018.06.001
   Maier L, 2018, NATURE, V555, P623, DOI 10.1038/nature25979
   MOLLY K, 1994, MICROB ECOL HEALTH D, V7, P191, DOI 10.3109/08910609409141354
   Moritz S, 2017, R J, V9, P207
   Nasrin F., 2014, IJPDA, V3, P220
   Nueda MJ, 2007, BIOINFORMATICS, V23, P1792, DOI 10.1093/bioinformatics/btm251
   Pallav K, 2014, GUT MICROBES, V5, P458, DOI 10.4161/gmic.29558
   Shah P, 2016, NAT COMMUN, V7, DOI 10.1038/ncomms11535
   Smilde AK, 2005, BIOINFORMATICS, V21, P3043, DOI 10.1093/bioinformatics/bti476
   Soki J, 2006, J ANTIMICROB CHEMOTH, V57, P212, DOI 10.1093/jac/dki443
   Sprouffske K, 2016, BMC BIOINFORMATICS, V17, DOI 10.1186/s12859-016-1016-7
   TUOMANEN E, 1986, J GEN MICROBIOL, V132, P1297
   Tyanova S, 2016, NAT METHODS, V13, P731, DOI [10.1038/NMETH.3901, 10.1038/nmeth.3901]
   Verhoeckx K., 2015, IMPACT FOOD BIOACTIV
   Walsh J, 2018, BRIT J PHARMACOL, V175, P4415, DOI 10.1111/bph.14366
   Wang XY, 2019, CELL RES, V29, P787, DOI 10.1038/s41422-019-0216-x
   Wexler HM, 2007, CLIN MICROBIOL REV, V20, P593, DOI 10.1128/CMR.00008-07
   Widdel F., 2007, DALAM GRUNDPRAKTIKUM, V4, P1
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Zhang X, 2016, MICROBIOME, V4, DOI 10.1186/s40168-016-0176-z
   Zhang XQ, 2015, SCI REP-UK, V5, DOI 10.1038/srep10737
   ZWIETERING MH, 1990, APPL ENVIRON MICROB, V56, P1875
NR 42
TC 4
Z9 4
U1 2
U2 25
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1044-0305
EI 1879-1123
J9 J AM SOC MASS SPECTR
JI J. Am. Soc. Mass Spectrom.
PD JUL 1
PY 2020
VL 31
IS 7
BP 1448
EP 1458
DI 10.1021/jasms.0c00054
PG 11
WC Biochemical Research Methods; Chemistry, Analytical; Chemistry,
   Physical; Spectroscopy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry; Spectroscopy
GA MI3TO
UT WOS:000547333700016
PM 32320607
DA 2023-06-08
ER

PT J
AU Jia, X
   Zhai, TY
   Qu, CJ
   Ye, JJ
   Zhao, J
   Liu, XR
   Zhang, JA
   Qian, QH
AF Jia, Xi
   Zhai, Tianyu
   Qu, Chunjie
   Ye, Jianjun
   Zhao, Jing
   Liu, Xuerong
   Zhang, Jin-an
   Qian, Qiaohui
TI Metformin Reverses Hashimoto's Thyroiditis by Regulating Key Immune
   Events
SO FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
LA English
DT Article
DE Hashimoto's thyroiditis; metformin; Th17 cells; intestinal flora; immune
ID AUTOIMMUNE; DIFFERENTIATION; MICROBIOTA; CELLS; TH17
AB Background Hashimoto's thyroiditis (HT) is a common autoimmune disease characterized by high levels of thyroid peroxidase antibody (TPOAb) and thyroid globulin antibody (TgAb) as well as infiltration of lymphocytes in thyroid. In recent years, metformin has been proven to be effective in a variety of autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis and multiple sclerosis. Methods This study systematically explored the therapeutic effect of metformin on HT and its underlying mechanism by comprehensively utilizing methods including animal model, in vitro cell culture and differentiation, mRNA sequencing and 16S rRNA sequencing. Findings We found that metformin indeed had a therapeutic effect on mice with HT mainly by reducing TgAb and lymphocyte infiltration in thyroid tissue. In addition, metformin also significantly suppressed the number and function of Th17 cells and M1 macrophages polarization in HT mice. Furthermore, metformin can inhibit the differentiation and function of Th17 in vitro. The results of mRNA sequencing of thyroid tissue illustrated that the therapeutic effect of metformin on HT was mainly achieved by regulating immune pathways. 16S RNA sequencing of the intestinal flora found that the intestinal flora of HT mice differs significantly from that of the normal mice and also were altered by metformin treatment. Interpretation These experiments provided a preliminary theoretical basis for the clinical application of metformin in the treatment of HT.
C1 [Jia, Xi; Zhai, Tianyu; Zhao, Jing; Liu, Xuerong; Zhang, Jin-an; Qian, Qiaohui] Shanghai Univ Med & Hlth Sci, Affiliated Zhoupu Hosp, Dept Endocrinol, Shanghai, Peoples R China.
   [Qu, Chunjie] Shanghai Pudong New Area Ctr Dis Control, Shanghai, Peoples R China.
   [Ye, Jianjun] Shanghai Kangqiao Community Hlth Serv Ctr, Shanghai, Peoples R China.
C3 Shanghai University of Medicine & Health Sciences
RP Zhang, JA; Qian, QH (通讯作者)，Shanghai Univ Med & Hlth Sci, Affiliated Zhoupu Hosp, Dept Endocrinol, Shanghai, Peoples R China.
EM zhangjinan@hotmail.com; 18917684029@189.com
RI ye, jian/GQH-3702-2022
FU National Natural Science Foundation of China [81873636, 81900710];
   Pudong New Area Health Commission key subspecialty [PWZy2020-12];
   Clinical Research Center of thyroid diseases of Shanghai Health Medical
   College [20MC20200002]; Project of Shanghai Medical Key Specialty
   [ZK2019C09]
FX The present work was supported by Grants from the National Natural
   Science Foundation of China (Nos. 81873636 and 81900710), Pudong New
   Area Health Commission key subspecialty (No. PWZy2020-12), Clinical
   Research Center of thyroid diseases of Shanghai Health Medical College
   (No. 20MC20200002) and The Project of Shanghai Medical Key Specialty
   (No. ZK2019C09).
CR Antonelli A, 2015, AUTOIMMUN REV, V14, P174, DOI 10.1016/j.autrev.2014.10.016
   Benvenga S, 2016, REV ENDOCR METAB DIS, V17, P485, DOI 10.1007/s11154-016-9363-2
   Consolandi C, 2015, AUTOIMMUN REV, V14, P269, DOI 10.1016/j.autrev.2014.11.009
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Figura N, 2020, ANTIBIOTICS-BASEL, V9, DOI 10.3390/antibiotics9010012
   Fujita Y, 2017, CURR DIABETES REP, V17, DOI 10.1007/s11892-017-0829-8
   Hasan Z, 2017, NAT COMMUN, V8, DOI 10.1038/ncomms15628
   Jia X, 2020, AUTOIMMUNITY, V53, P353, DOI 10.1080/08916934.2020.1789969
   Johnson JS, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-13036-1
   Kukurba Kimberly R, 2015, Cold Spring Harb Protoc, V2015, P951, DOI 10.1101/pdb.top084970
   Lee SY, 2017, J IMMUNOL, V198, P2661, DOI 10.4049/jimmunol.1403088
   Lee SY, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0135858
   Li CY, 2017, THYROID, V27, P722, DOI 10.1089/thy.2016.0432
   Li Q, 2019, J CELL PHYSIOL, V234, P2204, DOI 10.1002/jcp.27180
   Limagne E, 2017, CELL REP, V19, P746, DOI 10.1016/j.celrep.2017.04.004
   Lopez P, 2016, SCI REP-UK, V6, DOI 10.1038/srep24072
   Lu CH, 2019, MEDICINE, V98, DOI 10.1097/MD.0000000000017371
   Marcucci F, 2020, TRENDS PHARMACOL SCI, V41, P162, DOI 10.1016/j.tips.2020.01.003
   MILLER LJ, 1978, GASTROENTEROLOGY, V75, P901
   Misharin AV, 2013, AM J RESP CELL MOL, V49, P503, DOI 10.1165/rcmb.2013-0086MA
   Nafisa A, 2018, PHARMACOL THERAPEUT, V192, P150, DOI 10.1016/j.pharmthera.2018.07.007
   Qin Q, 2012, BRAZ J MED BIOL RES, V45, P1202, DOI 10.1590/S0100-879X2012007500168
   Rajaei E, 2019, CURR RHEUMATOL REV, V15, P116, DOI 10.2174/1573397114666180717145745
   Ralli M, 2020, AUTOIMMUN REV, V19, DOI 10.1016/j.autrev.2020.102649
   Sanschagrin S, 2014, JOVE-J VIS EXP, DOI 10.3791/51709
   Schuiveling M, 2018, CURR DRUG TARGETS, V19, P945, DOI 10.2174/1389450118666170613081730
   Shamriz O, 2016, AUTOIMMUN REV, V15, P859, DOI 10.1016/j.autrev.2016.07.012
   Soukas AA, 2019, TRENDS ENDOCRIN MET, V30, P745, DOI 10.1016/j.tem.2019.07.015
   SOUSA Maristella de Araújo Carvalho, 2016, Arq. Gastroenterol., V53, P185, DOI 10.1590/S0004-28032016000300012
   Sun FF, 2020, LUPUS SCI MED, V7, DOI 10.1136/lupus-2020-000429
   Sun YF, 2016, J NEUROIMMUNOL, V292, P58, DOI 10.1016/j.jneuroim.2016.01.014
   Taylor PN, 2018, NAT REV ENDOCRINOL, V14, P301, DOI 10.1038/nrendo.2018.18
   Ursini F, 2018, FRONT IMMUNOL, V9, DOI 10.3389/fimmu.2018.01236
   Vancura A, 2018, TRENDS PHARMACOL SCI, V39, P867, DOI 10.1016/j.tips.2018.07.006
   Venken K, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-018-07911-6
   Viard JP, 2017, NEW ENGL J MED, V376, P184
   Wang B, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.01397
   Wang HT, 2015, ARTHRITIS RHEUMATOL, V67, P3190, DOI 10.1002/art.39296
   Yeoh N, 2013, CURR RHEUMATOL REP, V15, DOI 10.1007/s11926-012-0314-y
   Zheng JP, 2020, J ETHNOPHARMACOL, V248, DOI 10.1016/j.jep.2019.112330
NR 40
TC 5
Z9 6
U1 3
U2 23
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-634X
J9 FRONT CELL DEV BIOL
JI Front. Cell. Dev. Biol.
PD MAY 28
PY 2021
VL 9
AR 685522
DI 10.3389/fcell.2021.685522
PG 11
WC Cell Biology; Developmental Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Developmental Biology
GA SQ0PV
UT WOS:000660064200001
PM 34124070
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Cabreiro, F
   Au, C
   Leung, KY
   Vergara-Irigaray, N
   Cocheme, HM
   Noori, T
   Weinkove, D
   Schuster, E
   Greene, NDE
   Gems, D
AF Cabreiro, Filipe
   Au, Catherine
   Leung, Kit-Yi
   Vergara-Irigaray, Nuria
   Cocheme, Helena M.
   Noori, Tahereh
   Weinkove, David
   Schuster, Eugene
   Greene, Nicholas D. E.
   Gems, David
TI Metformin Retards Aging in C. elegans by Altering Microbial Folate and
   Methionine Metabolism
SO CELL
LA English
DT Article
ID LIFE-SPAN EXTENSION; CAENORHABDITIS-ELEGANS; DIETARY RESTRICTION; GUT
   MICROBIOTA; DIABETES-MELLITUS; ESCHERICHIA-COLI; HOST; GENETICS; MODEL;
   HOMEOSTASIS
AB The biguanide drug metformin is widely prescribed to treat type 2 diabetes and metabolic syndrome, but its mode of action remains uncertain. Metformin also increases lifespan in Caenorhabditis elegans co-cultured with Escherichia coli. This bacterium exerts complex nutritional and pathogenic effects on its nematode predator/host that impact health and aging. We report that metformin increases lifespan by altering microbial folate and methionine metabolism. Alterations in metformin-induced longevity by mutation of worm methionine synthase (metr-1) and S-adenosylmethionine synthase (sams-1) imply metformin-induced methionine restriction in the host, consistent with action of this drug as a dietary restriction mimetic. Metformin increases or decreases worm lifespan, depending on E. coli strain metformin sensitivity and glucose concentration. In mammals, the intestinal microbiome influences host metabolism, including development of metabolic disease. Thus, metformin-induced alteration of microbial metabolism could contribute to therapeutic efficacy-and also to its side effects, which include folate deficiency and gastrointestinal upset.
C1 [Cabreiro, Filipe; Au, Catherine; Vergara-Irigaray, Nuria; Cocheme, Helena M.; Noori, Tahereh; Schuster, Eugene; Gems, David] UCL, Inst Hlth Ageing, London WC1E 6BT, England.
   [Cabreiro, Filipe; Au, Catherine; Vergara-Irigaray, Nuria; Cocheme, Helena M.; Noori, Tahereh; Schuster, Eugene; Gems, David] UCL, GEE, London WC1E 6BT, England.
   [Leung, Kit-Yi; Greene, Nicholas D. E.] UCL, Neural Dev Unit, Inst Child Hlth, London WC1N 1EH, England.
   [Weinkove, David] Univ Durham, Sch Biol & Biomed Sci, Durham DH1 3LE, England.
C3 University of London; University College London; University of London;
   University College London; University of London; University College
   London; N8 Research Partnership; Durham University
RP Gems, D (通讯作者)，UCL, Inst Hlth Ageing, Mortimer St, London WC1E 6BT, England.
EM david.gems@ucl.ac.uk
RI Weinkove, David/B-4470-2010
OI Gems, David/0000-0002-6653-4676; Greene, Nicholas
   D.E./0000-0002-4170-5248; Weinkove, David/0000-0001-7399-1202; Au,
   Catherine/0000-0002-1923-9121; Schuster, Eugene/0000-0001-5076-2810;
   Cocheme, Helena/0000-0001-8637-0042; Cabreiro,
   Filipe/0000-0002-3696-4843
FU Wellcome Trust (Strategic Award); European Union (LifeSpan); MRC
   [J003794]; BBSRC [BB/H01974X/1] Funding Source: UKRI; MRC [G0800339,
   MR/J003794/1] Funding Source: UKRI; Biotechnology and Biological
   Sciences Research Council [BB/H01974X/1] Funding Source: researchfish;
   Medical Research Council [G0800339, MR/J003794/1] Funding Source:
   researchfish
FX We thank Dan Ackerman, Joy Alcedo, Nazif Alic, Caroline Araiz, Alex
   Benedetto, Steve Clarke, Goncalo Correia, Monica Driscoll, Michael
   Murphy, Brian Onken, Matthew Piper, Bhupinder Virk, and Matthias Ziehm
   for useful discussion and other help. Strains were provided by the CGC
   and CGSC (DBI-0742708). We acknowledge funding from the Wellcome Trust
   (Strategic Award), the European Union (LifeSpan) and the MRC (J003794).
CR Anisimov VN, 2011, AGING-US, V3, P148, DOI 10.18632/aging.100273
   Backhed F, 2005, SCIENCE, V307, P1915, DOI 10.1126/science.1104816
   Bailey CJ, 2008, DIABETOLOGIA, V51, P1552, DOI 10.1007/s00125-008-1053-5
   BANERJEE RV, 1990, FASEB J, V4, P1450, DOI 10.1096/fasebj.4.5.2407589
   BRENNER S, 1974, GENETICS, V77, P71
   Bytzer P, 2001, ALIMENT PHARM THER, V15, P137, DOI 10.1046/j.1365-2036.2001.00896.x
   Cani PD, 2007, CURR OPIN CLIN NUTR, V10, P729, DOI 10.1097/MCO.0b013e3282efdebb
   Delzenne NM, 2011, NAT REV ENDOCRINOL, V7, P639, DOI 10.1038/nrendo.2011.126
   Delzenne NM, 2011, CURR DIABETES REP, V11, P154, DOI 10.1007/s11892-011-0191-1
   Dowling RJO, 2011, BMC MED, V9, DOI 10.1186/1741-7015-9-33
   Garigan D, 2002, GENETICS, V161, P1101
   Garsin DA, 2003, SCIENCE, V300, P1921, DOI 10.1126/science.1080147
   Gems D, 2000, GENETICS, V154, P1597
   Grandison RC, 2009, NATURE, V462, P1061, DOI 10.1038/nature08619
   Hannich JT, 2009, DEV CELL, V16, P833, DOI 10.1016/j.devcel.2009.04.012
   Hansen M, 2005, PLOS GENET, V1, P119, DOI 10.1371/journal.pgen.0010017
   Hawley Simon A, 2003, J Biol, V2, P28, DOI 10.1186/1475-4924-2-28
   Ikeda T, 2007, APPL ENVIRON MICROB, V73, P6404, DOI 10.1128/AEM.00704-07
   Kaeberlein TL, 2006, AGING CELL, V5, P487, DOI 10.1111/j.1474-9726.2006.00238.x
   Kau AL, 2011, NATURE, V474, P327, DOI 10.1038/nature10213
   Kenyon CJ, 2010, NATURE, V464, P504, DOI 10.1038/nature08980
   Kurz CL, 2003, EMBO J, V22, P1451, DOI 10.1093/emboj/cdg159
   Kwon YK, 2008, NAT CHEM BIOL, V4, P602, DOI 10.1038/nchembio.108
   Labrousse A, 2000, CURR BIOL, V10, P1543, DOI 10.1016/S0960-9822(00)00833-2
   Lee SJ, 2009, CELL METAB, V10, P379, DOI 10.1016/j.cmet.2009.10.003
   Lenaerts I, 2008, J GERONTOL A-BIOL, V63, P242, DOI 10.1093/gerona/63.3.242
   Maier W, 2010, PLOS BIOL, V8, DOI 10.1371/journal.pbio.1000376
   Mair W, 2008, ANNU REV BIOCHEM, V77, P727, DOI 10.1146/annurev.biochem.77.061206.171059
   Martinez-Chantar ML, 2006, GASTROENTEROLOGY, V131, P223, DOI 10.1053/j.gastro.2006.04.019
   Mato JM, 2008, ANNU REV NUTR, V28, P273, DOI 10.1146/annurev.nutr.28.061807.155438
   McGee MD, 2011, AGING CELL, V10, P699, DOI 10.1111/j.1474-9726.2011.00713.x
   Membrez M, 2008, FASEB J, V22, P2416, DOI 10.1096/fj.07-102723
   Nicholson JK, 2012, SCIENCE, V336, P1262, DOI 10.1126/science.1223813
   Nijhout HF, 2004, J BIOL CHEM, V279, P55008, DOI 10.1074/jbc.M410818200
   Onken B, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0008758
   ORENTREICH N, 1993, J NUTR, V123, P269
   Ottaviani E, 2011, BIOGERONTOLOGY, V12, P599, DOI 10.1007/s10522-011-9352-5
   Pierotti MA, 2012, ONCOGENE
   Proctor WR, 2008, DRUG METAB DISPOS, V36, P1650, DOI 10.1124/dmd.107.020180
   Pyra KA, 2012, J NUTR, V142, P213, DOI 10.3945/jn.111.147132
   Sahin M, 2007, J DIABETES COMPLICAT, V21, P118, DOI 10.1016/j.jdiacomp.2005.10.005
   Saiki R, 2008, AGING CELL, V7, P291, DOI 10.1111/j.1474-9726.2008.00378.x
   Scarpello JHB, 2008, DIABETES VASC DIS RE, V5, P157, DOI 10.3132/dvdr.2008.027
   Slack C, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0047699
   Smith ED, 2008, BMC DEV BIOL, V8, DOI 10.1186/1471-213X-8-49
   Storelli G, 2011, CELL METAB, V14, P403, DOI 10.1016/j.cmet.2011.07.012
   Turnbaugh PJ, 2009, SCI TRANSL MED, V1, DOI 10.1126/scitranslmed.3000322
   Venn BJ, 2007, EUR J CLIN NUTR, V61, pS122, DOI 10.1038/sj.ejcn.1602942
   Virk B, 2012, BMC BIOL, V10, DOI 10.1186/1741-7007-10-67
   Walker AK, 2011, CELL, V147, P840, DOI 10.1016/j.cell.2011.09.045
   Wu DQ, 2009, AGING CELL, V8, P666, DOI 10.1111/j.1474-9726.2009.00523.x
   Zilber-Rosenberg I, 2008, FEMS MICROBIOL REV, V32, P723, DOI 10.1111/j.1574-6976.2008.00123.x
NR 52
TC 616
Z9 637
U1 22
U2 281
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 0092-8674
J9 CELL
JI Cell
PD MAR 28
PY 2013
VL 153
IS 1
BP 228
EP 239
DI 10.1016/j.cell.2013.02.035
PG 12
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA 116AI
UT WOS:000316853700019
PM 23540700
OA Green Published, hybrid, Green Accepted
HC Y
HP N
DA 2023-06-08
ER

PT J
AU Elbere, I
   Kalnina, I
   Silamikelis, I
   Konrade, I
   Zaharenko, L
   Sekace, K
   Radovica-Spalvina, I
   Fridmanis, D
   Gudra, D
   Pirags, V
   Klovins, J
AF Elbere, Ilze
   Kalnina, Ineta
   Silamikelis, Ivars
   Konrade, Ilze
   Zaharenko, Linda
   Sekace, Kristine
   Radovica-Spalvina, Ilze
   Fridmanis, Davids
   Gudra, Dita
   Pirags, Valdis
   Klovins, Janis
TI Association of metformin administration with gut microbiome dysbiosis in
   healthy volunteers
SO PLOS ONE
LA English
DT Article
ID ESCHERICHIA-COLI; TYPE-2; SENSITIVITY; CLOSTRIDIUM; PROFILES; THERAPY;
   INSULIN; RISK
AB Background
   Metformin is a widely used first-line drug for treatment of type 2 diabetes. Despite its advantages, metformin has variable therapeutic effects, contraindications, and side effects. Here, for the very first time, we investigate the short-term effect of metformin on the composition of healthy human gut microbiota.
   Methods
   We used an exploratory longitudinal study design in which the first sample from an individual was the control for further samples. Eighteen healthy individuals were treated with metformin (2 x 850 mg) for 7 days. Stool samples were collected at three time points: prior to administration, 24 hours and 7 days after metformin administration. Taxonomic composition of the gut microbiome was analyzed by massive parallel sequencing of 16S rRNA gene (V3 region).
   Results
   There was a significant reduction of inner diversity of gut microbiota observed already 24 hours after metformin administration. We observed an association between the severity of gastrointestinal side effects and the increase in relative abundance of common gut opportunistic pathogen Escherichia-Shigella spp. One week long treatment with metformin was associated with a significant decrease in the families Peptostreptococcaceae and Clostridiaceae_ 1 and four genera within these families.
   Conclusions
   Our results are in line with previous findings on the capability of metformin to influence gut microbiota. However, for the first time we provide evidence that metformin has an immediate effect on the gut microbiome in humans. It is likely that this effect results from the increase in abundance of opportunistic pathogens and further triggers the occurrence of side effects associated with the observed dysbiosis. An additional randomized controlled trial would be required in order to reach definitive conclusions, as this is an exploratory study without a placebo control arm. Our findings may be further used to create approaches that improve the tolerability of metformin.
C1 [Elbere, Ilze; Kalnina, Ineta; Silamikelis, Ivars; Zaharenko, Linda; Sekace, Kristine; Radovica-Spalvina, Ilze; Fridmanis, Davids; Gudra, Dita; Pirags, Valdis; Klovins, Janis] Latvian Biomed Res & Study Ctr, Riga, Latvia.
   [Konrade, Ilze] Riga East Clin Univ Hosp, Riga, Latvia.
   [Pirags, Valdis] Pauls Stradins Clin Univ Hosp, Dept Endocrinol, Riga, Latvia.
   [Klovins, Janis] Univ Latvia, Fac Biol, Riga, Latvia.
C3 Latvian Biomedical Research & Study Centre; Riga East University
   Hospital; Pauls Stradins Clinical University Hospital; University of
   Latvia
RP Klovins, J (通讯作者)，Latvian Biomed Res & Study Ctr, Riga, Latvia.; Klovins, J (通讯作者)，Univ Latvia, Fac Biol, Riga, Latvia.
EM klovins@biomed.lu.lv
RI Fridmanis, Davids/I-3292-2017; Pirags, Valdis/AAQ-5492-2020; Kalnina,
   Ineta/AAY-9281-2020; Klovins, Janis/C-5695-2011
OI Fridmanis, Davids/0000-0003-0310-0448; Pirags,
   Valdis/0000-0002-3650-7394; Gudra, Dita/0000-0002-9446-4521; Elbere,
   Ilze/0000-0003-4381-885X; Klovins, Janis/0000-0001-8362-5505; Kalnina,
   Ineta/0000-0003-3462-3196; Silamikelis, Ivars/0000-0002-7932-1047
FU National Research programme "Biomedicine for Public Health"
   (BIOMEDICINE) [2]
FX The study was funded by The National Research programme "Biomedicine for
   Public Health" (BIOMEDICINE). Project No 2 "Molecular Mechanisms,
   Pharmacogenetics and New Medicines for Treatment of Diabetes and
   Cardiovascular Complications". The funders had no role in study design,
   data collection and analysis, decision to publish, or preparation of the
   manuscript.
CR Amato SM, 2013, MOL CELL, V50, P475, DOI 10.1016/j.molcel.2013.04.002
   American Diabetes Association, 2010, Diabetes Care, V33 Suppl 1, pS11, DOI 10.2337/dc10-S011
   Asif Mohammad, 2014, J Educ Health Promot, V3, P1, DOI 10.4103/2277-9531.127541
   Barzilai N, 2016, CELL METAB, V23, P1060, DOI 10.1016/j.cmet.2016.05.011
   Bolen S, 2007, ANN INTERN MED, V147, P386, DOI 10.7326/0003-4819-147-6-200709180-00178
   BONORA E, 1984, CURR MED RES OPIN, V9, P47, DOI 10.1185/03007998409109558
   Burton JH, 2015, J DIABETES SCI TECHN
   Buse JB, 2016, DIABETES CARE, V39, P198, DOI 10.2337/dc15-0488
   Cardona S, 2012, BMC MICROBIOL, V12, DOI 10.1186/1471-2180-12-158
   Chen Q, 2012, PLOS ONE, V7
   Cox LM, 2013, FASEB J, V27, P692, DOI 10.1096/fj.12-219477
   de la Cuesta-Zuluaga J, 2016, DIABETES CARE
   Dujic T, 2016, DIABETIC MED, V33, P511, DOI 10.1111/dme.13040
   Duvallet C, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-01973-8
   Edgar RC, 2011, BIOINFORMATICS, V27, P2194, DOI 10.1093/bioinformatics/btr381
   Evans JMM, 2005, BMJ-BRIT MED J, V330, P1304, DOI 10.1136/bmj.38415.708634.F7
   Fan PX, 2017, SCI REP-UK, V7, DOI 10.1038/srep43412
   Florez H, 2010, POSTGRAD MED, V122, P112, DOI 10.3810/pgm.2010.03.2128
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Francino MP, 2016, FRONT MICROBIOL, V6, DOI 10.3389/fmicb.2015.01543
   Fung CSC, 2015, CARDIOVASC DIABETOL, V14, DOI 10.1186/s12933-015-0304-2
   Gao YD, 2014, BIOMED RES INT, V2014, DOI 10.1155/2014/694967
   Gerritsen J, 2014, INT J SYST EVOL MICR, V64, P1600, DOI 10.1099/ijs.0.059543-0
   Goodrich JK, 2014, CELL, V158, P250, DOI 10.1016/j.cell.2014.06.037
   Graham GG, 2011, CLIN PHARMACOKINET, V50, P81, DOI 10.2165/11534750-000000000-00000
   Gupta A, 2011, NEUROPHARMACOLOGY, V60, P910, DOI 10.1016/j.neuropharm.2011.01.033
   HAUPT E, 1991, DIABETES METAB, V17, P224
   Hoffmann Irene S, 2003, Am J Ther, V10, P447, DOI 10.1097/00045391-200311000-00012
   Howlett HCS, 1999, DRUG SAFETY, V20, P489, DOI 10.2165/00002018-199920060-00003
   Inzucchi SE, 2015, DIABETES CARE, V38, P140, DOI 10.2337/dc14-2441
   Jiang WW, 2015, SCI REP-UK, V5, DOI 10.1038/srep08096
   Johnson JR, 2000, J MED MICROBIOL, V49, P583, DOI 10.1099/0022-1317-49-7-583
   Jones SA, 2007, INFECT IMMUN, V75, P4891, DOI 10.1128/IAI.00484-07
   Kirpichnikov D, 2002, ANN INTERN MED, V137, P25, DOI 10.7326/0003-4819-137-1-200207020-00009
   Lavelle A, 2015, GUT, V64, P1553, DOI 10.1136/gutjnl-2014-307873
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Lilly M, 2009, CAN FAM PHYSICIAN, V55, P363
   Maniar K, 2017, MED HYPOTHESES, V104, P117, DOI 10.1016/j.mehy.2017.06.001
   Mattila E, 2012, GASTROENTEROLOGY, V142, P490, DOI 10.1053/j.gastro.2011.11.037
   McCreight LJ, 2016, DIABETOLOGIA, V59, P426, DOI 10.1007/s00125-015-3844-9
   Milani C, 2016, SCI REP-UK, V6, DOI 10.1038/srep25945
   Milani C, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0068739
   Moghetti P, 2000, J CLIN ENDOCR METAB, V85, P139, DOI 10.1210/jc.85.1.139
   Morton ER, 2015, PLOS GENET, V11, DOI 10.1371/journal.pgen.1005658
   Napolitano A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100778
   Nasri H, 2014, J RES MED SCI, V19, P658
   Quast Christian, 2013, Nucleic Acids Res, V41, pD590, DOI 10.1093/nar/gks1219
   Rossi O, 2016, SCI REP-UK, V6, DOI 10.1038/srep18507
   Rovite V, 2018, J EPIDEMIOL
   Schloss PD, 2009, APPL ENVIRON MICROB, V75, P7537, DOI 10.1128/AEM.01541-09
   Segata N, 2011, GENOME BIOL, V12, DOI 10.1186/gb-2011-12-6-r60
   Shannon C. E., 1948, BELL SYST TECH J, V27, P379, DOI [10.1002/j.1538-7305.1948.tb01338.x, DOI 10.1002/J.1538-7305.1948.TB00917.X, DOI 10.1002/J.1538-7305.1948.TB01338.X]
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Sims GE, 2011, P NATL ACAD SCI USA, V108, P8329, DOI 10.1073/pnas.1105168108
   Tedjo DI, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0126685
   Ticinesi A, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-10734-y
   Touchon M, 2009, PLOS GENET, V5, DOI 10.1371/journal.pgen.1000344
   Wang Q, 2007, APPL ENVIRON MICROB, V73, P5261, DOI 10.1128/AEM.00062-07
   Wlodarska M, 2015, SCI REP-UK, V5, DOI 10.1038/srep09253
   Wu H, 2017, NAT MED
   Zhang CH, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms3163
   Zhang XQ, 2015, SCI REP-UK, V5, DOI 10.1038/srep10737
NR 62
TC 68
Z9 70
U1 1
U2 17
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 27
PY 2018
VL 13
IS 9
AR e0204317
DI 10.1371/journal.pone.0204317
PG 17
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA GV2HB
UT WOS:000445907400036
PM 30261008
OA Green Submitted, Green Published, gold
DA 2023-06-08
ER

PT J
AU Zheng, JL
   Li, H
   Zhang, XJ
   Jiang, M
   Luo, CQ
   Lu, ZM
   Xu, ZH
   Shi, JS
AF Zheng, Jialin
   Li, Heng
   Zhang, Xiaojuan
   Jiang, Min
   Luo, Chunqin
   Lu, Zhenming
   Xu, Zhenghong
   Shi, Jinsong
TI Prebiotic Mannan-Oligosaccharides Augment the Hypoglycemic Effects of
   Metformin in Correlation with Modulating Gut Microbiota
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Article
DE konjac mannan-oligosaccharides (MOS); gut microbiota; type 2 diabetes;
   metformin
ID IMPROVES INSULIN SENSITIVITY; INTESTINAL MICROBIOTA; OXIDATIVE STRESS;
   KONJAC MANNAN; OBESITY; IMPACT; HYPERGLYCEMIA; RESISTANCE; MECHANISM;
   MODEL
AB Type 2 diabetes (T2D) induced by obesity and high-fat diet is significantly associated with gut microbiota dysbacteriosis. Because the first line clinical medicine of metformin has several intestinal drawbacks, combination usage of metformin with a prebiotic of konjac mannan-oligosaccharides (MOS) was conceived and implemented aiming to investigate whether there were some intestinal synergetic effects and how MOS would function. Composite treatment of metformin and MOS demonstrated synergistic effects on ameliorating insulin resistance and glucose tolerance, also on repairing islet and hepatic histology. In addition, MF+MOS altered the gut community composition and structure by decreasing the relative abundances of family Rikenellaceae and order Clostridiales while increasing an unnamed OTU05945 of family S24-7, Akkermansia muciniphila, and Bifidobacterium pseudolongum. The present study suggested that usage of MOS could augment the hypoglycemic effects of metformin in association with gut microbiota modulation, which could provide references for further medication.
C1 [Zheng, Jialin; Li, Heng; Jiang, Min; Shi, Jinsong] Jiangnan Univ, Minist Educ, Sch Pharmaceut Sci, Key Lab Carbohydrate Chem & Biotechnol, 1800 Lihu Ave, Wuxi 214122, Peoples R China.
   [Zhang, Xiaojuan; Lu, Zhenming; Xu, Zhenghong] Jiangnan Univ, Natl Engn Lab Cereal Fermentat Technol, 1800 Lihu Ave, Wuxi 214122, Peoples R China.
   [Xu, Zhenghong] Jiangnan Univ, Sch Biotechnol, 1800 Lihu Ave, Wuxi 214122, Peoples R China.
   [Luo, Chunqin] Chengdu Yongan Yuanhe Biotechnol Co, Fifth Tianfu St, Chengdu 611630, Sichuan, Peoples R China.
C3 Jiangnan University; Jiangnan University; Jiangnan University
RP Li, H; Shi, JS (通讯作者)，Jiangnan Univ, Minist Educ, Sch Pharmaceut Sci, Key Lab Carbohydrate Chem & Biotechnol, 1800 Lihu Ave, Wuxi 214122, Peoples R China.
EM liheng@jiangnan.edu.cn; shijs@163.com
RI Jiang, Min/AAJ-9579-2020
OI Jiang, Min/0000-0003-3826-6405; Xu, Zheng-Hong/0000-0003-1340-6838
FU National First-Class Discipline Program of Light Industry Technology and
   Engineering [LITE2018-18, LITE2018-11]; Transformation Project for Major
   Scientific and Technological Achievements in Jiangsu Province
   [BA2015006]; Industry-Academia Cooperation Innovation Fund Project of
   Jiangsu Province [BY2016022-19]; National Key Technology R&D Program of
   China for the 12th Five-year Plan [2012BAD33B06]
FX This work was financially supported by the National First-Class
   Discipline Program of Light Industry Technology and Engineering
   (LITE2018-18, LITE2018-11), Transformation Project for Major Scientific
   and Technological Achievements in Jiangsu Province (No. BA2015006),
   Industry-Academia Cooperation Innovation Fund Project of Jiangsu
   Province (No. BY2016022-19) and the National Key Technology R&D Program
   of China for the 12th Five-year Plan (No. 2012BAD33B06). Authors also
   thank professor Jun Liu from University of Toronto for manuscript
   preparation.
CR [Anonymous], 2015, BIOACTIVE CARBOHYDRA, DOI DOI 10.1016/J.BCDF.2015.03.007
   Aoe S, 2015, BIOSCI BIOTECH BIOCH, V79, P1141, DOI 10.1080/09168451.2015.1018119
   Bosi E, 2009, DIABETES OBES METAB, V11, P3, DOI 10.1111/j.1463-1326.2008.01031.x
   Burcelin R, 2011, ACTA DIABETOL, V48, P257, DOI 10.1007/s00592-011-0333-6
   Cani PD, 2009, GUT, V58, P1091, DOI 10.1136/gut.2008.165886
   Chassaing B, 2015, NATURE, V519, P92, DOI 10.1038/nature14232
   Chatterjee S, 2017, LANCET, V389, P2239, DOI 10.1016/S0140-6736(17)30058-2
   Chen HL, 2003, J AM COLL NUTR, V22, P36, DOI 10.1080/07315724.2003.10719273
   Daniel H, 2014, ISME J, V8, P295, DOI 10.1038/ismej.2013.155
   Dao MC, 2016, GUT, V65, P426, DOI 10.1136/gutjnl-2014-308778
   Elamir AA, 2008, NUTR FOOD SCI, V38, P422, DOI 10.1108/00346650810906930
   Everard A, 2014, MBIO, V5, DOI 10.1128/mBio.01011-14
   Garcia-Garcia J.M., 2017, EMOTION DETECTION TE, P1, DOI [10.1145/3123818.3123852, DOI 10.1145/3123818.3123852, DOI 10.1007/S11356-017-8975-8]
   Gilbert ER, 2011, EXP DIABETES RES, DOI 10.1155/2011/416254
   LeBlanc JG, 2013, CURR OPIN BIOTECH, V24, P160, DOI 10.1016/j.copbio.2012.08.005
   Herrmann E, 2017, BIOMED RES INT, V2017, DOI 10.1155/2017/1829685
   Holmes David, 2016, Nat Rev Endocrinol, V12, P312, DOI 10.1038/nrendo.2016.41
   Hsieh PS, 2011, WORLD J GASTROENTERO, V17, P5240, DOI 10.3748/wjg.v17.i48.5240
   Hundal RS, 2000, DIABETES, V49, P2063, DOI 10.2337/diabetes.49.12.2063
   Jiang GJ, 2017, PEERJ, V5, DOI 10.7717/peerj.3155
   Jiang M, 2016, PROG BIOCHEM BIOPHYS, V43, P271
   Karlsson F, 2013, DIABETES, V62, P3341, DOI 10.2337/db13-0844
   KATO K, 1970, AGR BIOL CHEM TOKYO, V34, P532, DOI 10.1080/00021369.1970.10859645
   Kim YA, 2018, NUTR RES REV, V31, P35, DOI 10.1017/S095442241700018X
   Knowler WC, 2002, NEW ENGL J MED, V346, P393, DOI 10.1056/NEJMoa012512
   Kootte RS, 2017, CELL METAB, V26, P611, DOI 10.1016/j.cmet.2017.09.008
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Li X, 2017, BENEF MICROBES, V8, P421, DOI 10.3920/BM2016.0167
   Li XP, 2016, J FUNCT FOODS, V27, P711, DOI 10.1016/j.jff.2016.08.010
   Liu JH, 2015, CARBOHYD POLYM, V130, P398, DOI 10.1016/j.carbpol.2015.05.025
   Lu XJ, 2002, LIFE SCI, V72, P711, DOI 10.1016/S0024-3205(02)02303-2
   Mao BY, 2015, J AGR FOOD CHEM, V63, P856, DOI 10.1021/jf505156h
   Mathur R., 2014, RES J ENDOCRINOLOGY, V2, P1
   Mathur R, 2016, OBESITY, V24, P576, DOI 10.1002/oby.21385
   Mirzapour-Rezaee SS, 2017, AQUACULT NUTR, V23, P629, DOI 10.1111/anu.12430
   Pedersen HK, 2016, NATURE, V535, P376, DOI 10.1038/nature18646
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Razmpoosh E, 2016, DIABETES-METAB RES, V32, P143, DOI 10.1002/dmrr.2665
   Romond MB, 2008, ANAEROBE, V14, P43, DOI 10.1016/j.anaerobe.2007.09.003
   Smith DL, 2010, OBESITY, V18, P995, DOI 10.1038/oby.2009.308
   Spring P., 2015, Journal of Applied Animal Nutrition, V2015, pe8
   Tan CQ, 2016, APPL ENVIRON MICROB, V82, P5899, DOI 10.1128/AEM.01374-16
   Tomas J, 2016, P NATL ACAD SCI USA, V113, pE5934, DOI 10.1073/pnas.1612559113
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Vaarala O, 2013, CURR DIABETES REP, V13, P601, DOI 10.1007/s11892-013-0409-5
   Wang YY, 2017, CHEM ENG J, V317, P512, DOI 10.1016/j.cej.2017.02.096
   Yang JY, 2017, MUCOSAL IMMUNOL, V10, P104, DOI 10.1038/mi.2016.42
   Zhao LJ, 2017, THER CLIN RISK MANAG, V13, P739, DOI 10.2147/TCRM.S134039
   Zhou J, 2015, TOXICOL APPL PHARM, V289, P409, DOI 10.1016/j.taap.2015.10.019
NR 49
TC 59
Z9 65
U1 6
U2 131
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
EI 1520-5118
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD JUN 13
PY 2018
VL 66
IS 23
BP 5821
EP 5831
DI 10.1021/acsjafc.8b00829
PG 11
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA GJ6WT
UT WOS:000435525800011
PM 29701959
DA 2023-06-08
ER

PT J
AU Zhang, W
   Xu, JH
   Yu, T
   Chen, QK
AF Zhang, Wang
   Xu, Ji-Hao
   Yu, Tao
   Chen, Qi-Kui
TI Effects of berberine and metformin on intestinal inflammation and gut
   microbiome composition in db/db mice
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Berberine; Metformin; Intestinal inflammation; Intestinal barrier; Gut
   microbes
ID DIET; PREVENTION; MECHANISM; INSULIN; CANCER
AB Berberine and metformin, both established pharmaceutical agents with herbal origins, have incidental beneficial effects on multiple diseases, including diabetes. These effects have been speculated to occur via the gut microbiome. In this study, we administered either berberine or metformin to db/db mice and investigated changes in body weight, food intake, and blood glucose levels. Fresh stool samples were analyzed using 16 s rDNA high-throughput sequencing to evaluate the gut microbiome. Short-chain fatty acids (SCFA) in the stool were quantified using gas chromatography. The expression of NF-kappa B signaling pathway and tight junction (ZO1 and occludin) proteins in the intestinal epithelium was determined using qPCR and western blotting. The intestinal barrier structure was examined using transmission electron microscopy and serum lipopolysaccharide (LPS) was measured using a commercial kit. Both berberine and metformin reduced food intake, body weight, and blood glucose and HbA1c levels. Both treatments effectively restored the intestinal SCFA content, reduced the level of serum LPS, relieved intestinal inflammation, and repaired intestinal barrier structure. Intervention with metformin or berberine modified the gut microbiome in db/db mice, increasing the number of SCFA-producing bacteria (e.g., Butyricimonas, Coprococcus, Ruminococcus) and reducing opportunistic pathogens (e.g., Prevotella, Proteus). An increased abundance of other probiotics including Lactobacillus and Akkermansia was also observed. Berberine and metformin can modulate the composition of the gut microbiome and reduce body weight, blood glucose levels, and intestinal inflammation in db/db mice, which demonstrates their effectiveness in the reduction of diabetic complications in this model.
C1 [Zhang, Wang; Xu, Ji-Hao; Yu, Tao; Chen, Qi-Kui] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Gastroenterol, 107 Yan Jiang Xi Rd, Guangzhou 510120, Guangdong, Peoples R China.
   [Zhang, Wang] Guangzhou Univ Chinese Med, Dept Gastroenterol, Affiliated Hosp 2, 111 Da De Rd, Guangzhou 510120, Guangdong, Peoples R China.
C3 Sun Yat Sen University; Guangzhou University of Chinese Medicine
RP Chen, QK (通讯作者)，Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Gastroenterol, 107 Yan Jiang Xi Rd, Guangzhou 510120, Guangdong, Peoples R China.
EM qkchen2018@163.com
FU National Natural Science Foundation of China [81703995, 81270442,
   81370475]
FX This study was supported by National Natural Science Foundation of China
   (grant nos. 81703995, 81270442, and 81370475).
CR Bailey CJ, 2017, DIABETOLOGIA, V60, P1566, DOI 10.1007/s00125-017-4318-z
   Bharti AC, 2002, BIOCHEM PHARMACOL, V64, P883, DOI 10.1016/S0006-2952(02)01154-1
   Biagi E, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0010667
   Byndloss MX, 2018, MUCOSAL IMMUNOL, V11, P1299, DOI 10.1038/s41385-018-0010-y
   Cabreiro F, 2013, CELL, V153, P228, DOI 10.1016/j.cell.2013.02.035
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Caporaso JG, 2010, NAT METHODS, V7, P335, DOI 10.1038/nmeth.f.303
   Dao MC, 2016, GUT, V65, P426, DOI 10.1136/gutjnl-2014-308778
   De Filippo C, 2010, P NATL ACAD SCI USA, V107, P14691, DOI 10.1073/pnas.1005963107
   DeSantis TZ, 2006, NUCLEIC ACIDS RES, V34, pW394, DOI 10.1093/nar/gkl244
   He L, 2009, CELL, V137, P635, DOI 10.1016/j.cell.2009.03.016
   Hua WY, 2007, J PHARMACEUT BIOMED, V44, P931, DOI 10.1016/j.jpba.2007.03.022
   Kong WJ, 2004, NAT MED, V10, P1344, DOI 10.1038/nm1135
   Lozupone C, 2005, APPL ENVIRON MICROB, V71, P8228, DOI 10.1128/AEM.71.12.8228-8235.2005
   Mahmood K, 2013, EUR J INTERN MED, V24, P20, DOI 10.1016/j.ejim.2012.10.011
   Martinez C, 2013, GUT, V62, P1160, DOI 10.1136/gutjnl-2012-302093
   Maslowski KM, 2009, NATURE, V461, P1282, DOI 10.1038/nature08530
   Min XH, 2014, CELL BIOL INT, V38, P1194, DOI 10.1002/cbin.10323
   Murugesan S, 2018, EUR J CLIN MICROBIOL, V37, P621, DOI 10.1007/s10096-017-3143-0
   Neyrinck AM, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0020944
   Peng J, 2015, INT J CLIN EXP MED, V8, P10058
   Pollak M, 2017, DIABETOLOGIA, V60, P1662, DOI 10.1007/s00125-017-4352-x
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Ryan KK, 2014, NATURE, V509, P183, DOI 10.1038/nature13135
   Sano T, 2009, CANCER SCI, V100, P595, DOI 10.1111/j.1349-7006.2008.01081.x
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Smith PM, 2013, SCIENCE, V341, P569, DOI 10.1126/science.1241165
   Sonnenburg ED, 2010, CELL, V141, P1241, DOI 10.1016/j.cell.2010.05.005
   Takeda K, 2003, ANNU REV IMMUNOL, V21, P335, DOI 10.1146/annurev.immunol.21.120601.141126
   Tang J, 2009, J ETHNOPHARMACOL, V126, P5, DOI 10.1016/j.jep.2009.08.009
   Tibshirani R, 2002, P NATL ACAD SCI USA, V99, P6567, DOI 10.1073/pnas.082099299
   Vuddanda PR, 2010, EXPERT OPIN INV DRUG, V19, P1297, DOI 10.1517/13543784.2010.517745
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Xie WD, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0024520
   Zhang Qing, 2015, Zhongguo Zhong Yao Za Zhi, V40, P1660
   Zhang X, 2012, PLOS ONE, V7, DOI [10.1371/journal.pone.0040320, 10.1371/journal.pone.0042529]
   Zhang X, 2015, SCI REP-UK, V5, DOI 10.1038/srep14405
   Zhang YF, 2008, J CLIN ENDOCR METAB, V93, P2559, DOI 10.1210/jc.2007-2404
   Zhou GC, 2001, J CLIN INVEST, V108, P1167, DOI 10.1172/JCI200113505
NR 39
TC 111
Z9 114
U1 12
U2 89
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD OCT
PY 2019
VL 118
AR 109131
DI 10.1016/j.biopha.2019.109131
PG 10
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA IY4WZ
UT WOS:000486395000152
PM 31545226
OA gold
HC Y
HP N
DA 2023-06-08
ER

PT J
AU Lee, CB
   Chae, SU
   Jo, SJ
   Jerng, UM
   Bae, SK
AF Lee, Chae Bin
   Chae, Soon Uk
   Jo, Seong Jun
   Jerng, Ui Min
   Bae, Soo Kyung
TI The Relationship between the Gut Microbiome and Metformin as a Key for
   Treating Type 2 Diabetes Mellitus
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE gut microbiome; type 2 diabetes mellitus; metformin; dysbiosis
AB Metformin is the first-line pharmacotherapy for treating type 2 diabetes mellitus (T2DM); however, its mechanism of modulating glucose metabolism is elusive. Recent advances have identified the gut as a potential target of metformin. As patients with metabolic disorders exhibit dysbiosis, the gut microbiome has garnered interest as a potential target for metabolic disease. Henceforth, studies have focused on unraveling the relationship of metabolic disorders with the human gut microbiome. According to various metagenome studies, gut dysbiosis is evident in T2DM patients. Besides this, alterations in the gut microbiome were also observed in the metformin-treated T2DM patients compared to the non-treated T2DM patients. Thus, several studies on rodents have suggested potential mechanisms interacting with the gut microbiome, including regulation of glucose metabolism, an increase in short-chain fatty acids, strengthening intestinal permeability against lipopolysaccharides, modulating the immune response, and interaction with bile acids. Furthermore, human studies have demonstrated evidence substantiating the hypotheses based on rodent studies. This review discusses the current knowledge of how metformin modulates T2DM with respect to the gut microbiome and discusses the prospect of harnessing this mechanism in treating T2DM.
C1 [Lee, Chae Bin; Chae, Soon Uk; Jo, Seong Jun; Bae, Soo Kyung] Catholic Univ Korea, Coll Pharm, Bucheon 14662, South Korea.
   [Lee, Chae Bin; Chae, Soon Uk; Jo, Seong Jun; Bae, Soo Kyung] Catholic Univ Korea, Integrated Res Inst Pharmaceut Sci, Bucheon 14662, South Korea.
   [Jerng, Ui Min] Sangji Univ, Coll Korean Med, Dept Internal Med, Wonju 26339, South Korea.
C3 Catholic University of Korea; Catholic University of Korea; Sangji
   University
RP Bae, SK (通讯作者)，Catholic Univ Korea, Coll Pharm, Bucheon 14662, South Korea.; Bae, SK (通讯作者)，Catholic Univ Korea, Integrated Res Inst Pharmaceut Sci, Bucheon 14662, South Korea.
EM aribri727@catholic.ac.kr; zldtnseo@catholic.ac.kr;
   seongjun6734@catholic.ac.kr; healmind@paran.com; baesk@catholic.ac.kr
RI Jerng, Ui Min/G-1377-2014
OI Jerng, Ui Min/0000-0002-1996-3793
FU Basic Science Research Program through the National Research Foundation
   of Korea - Ministry of Education [2018R1A6A1A03025108]; Korea Health
   Technology R&D Project through the Korea Health Industry Development
   Institute (KHIDI) - Ministry of Health Welfare [HF20C0002]; Catholic
   University of Korea
FX This study was supported by a grant of Basic Science Research Program
   through the National Research Foundation of Korea, funded by the
   Ministry of Education (2018R1A6A1A03025108), Korea Health Technology R&D
   Project through the Korea Health Industry Development Institute (KHIDI),
   funded by the Ministry of Health & Welfare (HF20C0002), and Research
   Fund of The Catholic University of Korea (2020).
CR Rojas LBA, 2013, DIABETOL METAB SYNDR, V5, DOI 10.1186/1758-5996-5-6
   Ahmad A, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0226372
   Ahmadi S, 2020, J GERONTOL A-BIOL, V75, pE9, DOI 10.1093/gerona/glaa056
   Amar J, 2011, EMBO MOL MED, V3, P559, DOI 10.1002/emmm.201100159
   Andujar-Plata P, 2012, DIABETES RES CLIN PR, V95, P1, DOI 10.1016/j.diabres.2011.09.022
   Anhe FF, 2015, GUT, V64, P872, DOI 10.1136/gutjnl-2014-307142
   Artis D, 2004, P NATL ACAD SCI USA, V101, P13596, DOI 10.1073/pnas.0404034101
   Bailey CJ, 2008, DIABETOLOGIA, V51, P1552, DOI 10.1007/s00125-008-1053-5
   BAILEY CJ, 1994, BRIT J PHARMACOL, V112, P671, DOI 10.1111/j.1476-5381.1994.tb13128.x
   Balakumar M, 2018, EUR J NUTR, V57, P279, DOI 10.1007/s00394-016-1317-7
   Bauer PV, 2018, CELL METAB, V27, P572, DOI 10.1016/j.cmet.2018.01.013
   Bauer PV, 2018, CELL METAB, V27, P101, DOI 10.1016/j.cmet.2017.09.019
   BECKMANN R, 1969, DIABETOLOGIA, V5, P318, DOI 10.1007/BF00452906
   Belzer C, 2012, ISME J, V6, P1449, DOI 10.1038/ismej.2012.6
   Bharti AC, 2002, BIOCHEM PHARMACOL, V64, P883, DOI 10.1016/S0006-2952(02)01154-1
   BONORA E, 1984, CURR MED RES OPIN, V9, P47, DOI 10.1185/03007998409109558
   Brandt A, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-43228-0
   Brestoff JR, 2015, CELL, V161, P146, DOI 10.1016/j.cell.2015.02.022
   Brown JB, 2010, DIABETES CARE, V33, P501, DOI 10.2337/dc09-1749
   Bryrup T, 2019, DIABETOLOGIA, V62, P1024, DOI 10.1007/s00125-019-4848-7
   Buse JB, 2016, DIABETES CARE, V39, P198, DOI 10.2337/dc15-0488
   Cani PD, 2007, DIABETOLOGIA, V50, P2374, DOI 10.1007/s00125-007-0791-0
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   Cariou B, 2006, J BIOL CHEM, V281, P11039, DOI 10.1074/jbc.M510258200
   Carvalho BM, 2012, DIABETOLOGIA, V55, P2823, DOI 10.1007/s00125-012-2648-4
   Caslin B, 2019, P NATL ACAD SCI USA, V116, P25808, DOI 10.1073/pnas.1912359116
   CASPARY WF, 1975, DIABETOLOGIA, V11, P113, DOI 10.1007/BF00429833
   Chavez-Carbajal A, 2020, MICROORGANISMS, V8, DOI 10.3390/microorganisms8010094
   Chelakkot C, 2018, EXP MOL MED, V50, DOI 10.1038/emm.2017.282
   Chen LC, 2019, FOOD FUNCT, V10, P4372, DOI [10.1039/C9FO00406H, 10.1039/c9fo00406h]
   Chen P, 2014, NUTRITION, V30, P1061, DOI 10.1016/j.nut.2014.03.022
   Cherbut C, 1998, AM J PHYSIOL-GASTR L, V275, pG1415, DOI 10.1152/ajpgi.1998.275.6.G1415
   Clarke SF, 2012, GUT MICROBES, V3, P186, DOI 10.4161/gmic.20168
   Collado MC, 2007, APPL ENVIRON MICROB, V73, P7767, DOI 10.1128/AEM.01477-07
   Cui HX, 2019, FRONT MICROBIOL, V10, DOI 10.3389/fmicb.2019.01423
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Delzenne NM, 2015, DIABETOLOGIA, V58, P2206, DOI 10.1007/s00125-015-3712-7
   den Besten G, 2013, J LIPID RES, V54, P2325, DOI 10.1194/jlr.R036012
   Depommier C, 2019, NAT MED, V25, P1096, DOI 10.1038/s41591-019-0495-2
   Derrien M, 2008, APPL ENVIRON MICROB, V74, P1646, DOI 10.1128/AEM.01226-07
   Desai MS, 2016, CELL, V167, P1339, DOI 10.1016/j.cell.2016.10.043
   Duca FA, 2015, CELL METAB, V22, P367, DOI 10.1016/j.cmet.2015.07.003
   Duca FA, 2015, NAT MED, V21, P506, DOI 10.1038/nm.3787
   Dujic T, 2015, DIABETES, V64, P1786, DOI 10.2337/db14-1388
   Edwards JS, 2001, NAT BIOTECHNOL, V19, P125, DOI 10.1038/84379
   Ejtahed HS, 2012, NUTRITION, V28, P539, DOI 10.1016/j.nut.2011.08.013
   El Aidy S, 2013, GUT, V62, P1306, DOI 10.1136/gutjnl-2011-301955
   Elbere I, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0204317
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Fan Y, 2021, NAT REV MICROBIOL, V19, P55, DOI 10.1038/s41579-020-0433-9
   Feist AM, 2007, MOL SYST BIOL, V3, DOI 10.1038/msb4100155
   Florez H, 2012, J GEN INTERN MED, V27, P1594, DOI 10.1007/s11606-012-2122-5
   Foretz M, 2014, CELL METAB, V20, P953, DOI 10.1016/j.cmet.2014.09.018
   Foretz M, 2010, J CLIN INVEST, V120, P2355, DOI 10.1172/JCI40671
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Fredborg M, 2012, J ANIM SCI, V90, P10, DOI 10.2527/jas.53792
   Gao ZG, 2009, DIABETES, V58, P1509, DOI 10.2337/db08-1637
   Geer EB, 2009, GENDER MED, V6, P60, DOI 10.1016/j.genm.2009.02.002
   Gilbert JA, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0015545
   Gorboulev V, 2012, DIABETES, V61, P187, DOI 10.2337/db11-1029
   Graham GG, 2011, CLIN PHARMACOKINET, V50, P81, DOI 10.2165/11534750-000000000-00000
   Greer RL, 2016, NAT COMMUN, V7, DOI 10.1038/ncomms13329
   Gribble FM, 2003, DIABETES, V52, P1147, DOI 10.2337/diabetes.52.5.1147
   Gupta VK, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-18476-8
   Gurung M, 2020, EBIOMEDICINE, V51, DOI 10.1016/j.ebiom.2019.11.051
   Halawa MR, 2019, CURR DIABETES REV, V15, P480, DOI 10.2174/1573399815666190206162143
   Hansen CHF, 2013, EUR J IMMUNOL, V43, P447, DOI 10.1002/eji.201242462
   Hao ZK, 2020, J AM SOC MASS SPECTR, V31, P1448, DOI 10.1021/jasms.0c00054
   Harcombe WR, 2014, CELL REP, V7, P1104, DOI 10.1016/j.celrep.2014.03.070
   Harrell L, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0032545
   Heilbronn LK, 2008, CURR PHARM DESIGN, V14, P1225, DOI 10.2174/138161208784246153
   Hollister EB, 2014, GASTROENTEROLOGY, V146, P1449, DOI 10.1053/j.gastro.2014.01.052
   HOLZ GG, 1993, NATURE, V361, P362, DOI 10.1038/361362a0
   Hooper LV, 2001, SCIENCE, V292, P1115, DOI 10.1126/science.1058709
   Hu SE, 2010, AM J PHYSIOL-GASTR L, V299, pG1266, DOI 10.1152/ajpgi.00357.2010
   Huang F, 2018, INT J FOOD SCI NUTR, V69, P729, DOI 10.1080/09637486.2017.1408059
   Huang NL, 2009, INT J CARDIOL, V134, P169, DOI 10.1016/j.ijcard.2008.04.010
   Hur KY, 2015, J DIABETES INVEST, V6, P600, DOI 10.1111/jdi.12328
   Inan MS, 2000, GASTROENTEROLOGY, V118, P724, DOI 10.1016/S0016-5085(00)70142-9
   Jensen JB, 2016, DIABETES, V65, P1724, DOI 10.2337/db16-0032
   Ji SQ, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00704
   Johansson MEV, 2011, P NATL ACAD SCI USA, V108, P4659, DOI 10.1073/pnas.1006451107
   Johnson JS, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-13036-1
   Kang CS, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0076520
   Karaki S, 2006, CELL TISSUE RES, V324, P353, DOI 10.1007/s00441-005-0140-x
   Karaki SI, 2008, J MOL HISTOL, V39, P135, DOI 10.1007/s10735-007-9145-y
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Khat-udomkiri N, 2020, FOOD SCI NUTR, V8, P428, DOI 10.1002/fsn3.1327
   Kho ZY, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.01835
   Kim Young S, 2010, Curr Gastroenterol Rep, V12, P319, DOI 10.1007/s11894-010-0131-2
   Kinoshita M, 2002, BIOCHEM BIOPH RES CO, V293, P827, DOI 10.1016/S0006-291X(02)00294-2
   Koliada A, 2017, BMC MICROBIOL, V17, DOI 10.1186/s12866-017-1027-1
   Kong FL, 2016, CURR BIOL, V26, pR832, DOI 10.1016/j.cub.2016.08.015
   KORNMAN KS, 1982, INFECT IMMUN, V35, P256, DOI 10.1128/IAI.35.1.256-263.1982
   Kuhre RE, 2015, DIABETES, V64, P370, DOI 10.2337/db14-0807
   Lackey DE, 2016, NAT REV ENDOCRINOL, V12, P15, DOI 10.1038/nrendo.2015.189
   Lam TKT, 2010, NAT MED, V16, P392, DOI 10.1038/nm0410-392
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Le Chatelier E, 2013, NATURE, V500, P541, DOI 10.1038/nature12506
   Lee H, 2018, GUT MICROBES, V9, P155, DOI 10.1080/19490976.2017.1405209
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Lee SY, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0135858
   Lenzen S, 1996, BIOCHEM PHARMACOL, V51, P893, DOI 10.1016/0006-2952(95)02243-0
   Li F, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms3384
   Li SN, 2009, HEART VESSELS, V24, P446, DOI 10.1007/s00380-008-1137-7
   Li TG, 2014, PHARMACOL REV, V66, P948, DOI 10.1124/pr.113.008201
   Li X, 2017, BENEF MICROBES, V8, P421, DOI 10.3920/BM2016.0167
   Li X, 2016, J APPL MICROBIOL, V121, P1727, DOI 10.1111/jam.13276
   Lin HV, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0035240
   Liu GM, 2018, INT J BIOL MACROMOL, V115, P711, DOI 10.1016/j.ijbiomac.2018.04.127
   Liu GM, 2018, MOL NUTR FOOD RES, V62, DOI 10.1002/mnfr.201700954
   Liu YY, 2020, FASEB J, V34, P1065, DOI 10.1096/fj.201901943RR
   Louis S, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0149564
   Lumeng CN, 2011, J CLIN INVEST, V121, P2111, DOI 10.1172/JCI57132
   Lundberg R, 2016, GUT MICROBES, V7, P68, DOI 10.1080/19490976.2015.1127463
   Ma K, 2006, J CLIN INVEST, V116, P1102, DOI 10.1172/JCI25604
   Ma W, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.01336
   Macchione IG, 2019, EUR REV MED PHARMACO, V23, P8075, DOI 10.26355/eurrev_201909_19024
   Macfarlane S, 2003, P NUTR SOC, V62, P67, DOI 10.1079/PNS2002207
   Madiraju AK, 2014, NATURE, V510, P542, DOI 10.1038/nature13270
   Maida A, 2011, DIABETOLOGIA, V54, P339, DOI 10.1007/s00125-010-1937-z
   Manichanh C, 2014, GUT, V63, P401, DOI 10.1136/gutjnl-2012-303013
   Meng XM, 2017, EUR REV MED PHARMACO, V21, P2232
   Rodriguez JM, 2015, MICROB ECOL HEALTH D, V26, DOI 10.3402/mehd.v26.26050
   Morgan XC, 2012, GENOME BIOL, V13, DOI 10.1186/gb-2012-13-9-r79
   Moriya R, 2009, AM J PHYSIOL-ENDOC M, V297, pE1358, DOI 10.1152/ajpendo.00412.2009
   Napolitano A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100778
   Natali A, 2006, DIABETOLOGIA, V49, P434, DOI 10.1007/s00125-006-0141-7
   Osborn O, 2012, NAT MED, V18, P363, DOI 10.1038/nm.2627
   Overbeek R, 2014, NUCLEIC ACIDS RES, V42, pD206, DOI 10.1093/nar/gkt1226
   Panwar H, 2013, DIABETES-METAB RES, V29, P103, DOI 10.1002/dmrr.2376
   Parker HE, 2012, DIABETOLOGIA, V55, P2445, DOI 10.1007/s00125-012-2585-2
   Pathak P, 2018, HEPATOLOGY, V68, P1574, DOI 10.1002/hep.29857
   Plovier H, 2017, NAT MED, V23, P107, DOI 10.1038/nm.4236
   Png CW, 2010, AM J GASTROENTEROL, V105, P2420, DOI 10.1038/ajg.2010.281
   Prakash T, 2012, BRIEF BIOINFORM, V13, P711, DOI 10.1093/bib/bbs033
   Pryor R, 2019, CELL, V178, P1299, DOI 10.1016/j.cell.2019.08.003
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Rena G, 2017, DIABETOLOGIA, V60, P1577, DOI 10.1007/s00125-017-4342-z
   Rena G, 2013, DIABETOLOGIA, V56, P1898, DOI 10.1007/s00125-013-2991-0
   Rhee SI, 2014, INTEST RES, V12, P90, DOI 10.5217/ir.2014.12.2.90
   Rios-Covian D, 2013, APPL ENVIRON MICROB, V79, P7518, DOI 10.1128/AEM.02545-13
   Rodriguez J, 2018, CURR OPIN CLIN NUTR, V21, P294, DOI 10.1097/MCO.0000000000000468
   Rooj AK, 2010, BMC MICROBIOL, V10, DOI 10.1186/1471-2180-10-16
   Roopchand DE, 2015, DIABETES, V64, P2847, DOI 10.2337/db14-1916
   Rosario D, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.00775
   Rotter V, 2003, J BIOL CHEM, V278, P45777, DOI 10.1074/jbc.M301977200
   Ryan PM, 2020, CAN J DIABETES, V44, P146, DOI 10.1016/j.jcjd.2019.05.008
   Sansome DJ, 2020, DIABETES OBES METAB, V22, P141, DOI 10.1111/dom.13869
   Sato J, 2014, DIABETES CARE, V37, P2343, DOI 10.2337/dc13-2817
   Sayin SI, 2013, CELL METAB, V17, P225, DOI 10.1016/j.cmet.2013.01.003
   Scarpello JHB, 1998, DIABETIC MED, V15, P651, DOI 10.1002/(SICI)1096-9136(199808)15:8<651::AID-DIA628>3.0.CO;2-A
   Schmidt TSB, 2018, CELL, V172, P1198, DOI 10.1016/j.cell.2018.02.044
   Sen P, 2019, METABOLITES, V9, DOI 10.3390/metabo9020022
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Shu Y, 2007, J CLIN INVEST, V117, P1422, DOI 10.1172/JCI30558
   Song MJ, 2006, BIOCHEM BIOPH RES CO, V346, P739, DOI 10.1016/j.bbrc.2006.05.170
   Stepensky D, 2002, DRUG METAB DISPOS, V30, P861, DOI 10.1124/dmd.30.8.861
   SUEMORI S, 1991, P NATL ACAD SCI USA, V88, P11017, DOI 10.1073/pnas.88.24.11017
   Sun KY, 2017, CYTOKINE, V92, P1, DOI 10.1016/j.cyto.2017.01.003
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Tanaka T, 2008, N-S ARCH PHARMACOL, V377, P523, DOI 10.1007/s00210-007-0200-8
   Tanti JF, 2004, ANN ENDOCRINOL-PARIS, V65, P43, DOI 10.1016/S0003-4266(04)95629-6
   Tian PJ, 2016, FOOD FUNCT, V7, P3789, DOI [10.1039/c6fo00831c, 10.1039/C6FO00831C]
   Tolhurst G, 2012, DIABETES, V61, P364, DOI 10.2337/db11-1019
   Trabelsi MS, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms8629
   TUCKER GT, 1981, BRIT J CLIN PHARMACO, V12, P235
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Turnbaugh PJ, 2009, NATURE, V457, P480, DOI 10.1038/nature07540
   Vallianou NG, 2019, HORM-INT J ENDOCRINO, V18, P141, DOI 10.1007/s42000-019-00093-w
   van Passel MWJ, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0016876
   VANELDERE J, 1988, APPL ENVIRON MICROB, V54, P2112, DOI 10.1128/AEM.54.8.2112-2117.1988
   Vardarli I, 2014, DIABETES, V63, P663, DOI 10.2337/db13-0805
   Viollet B, 2012, CLIN SCI, V122, P253, DOI 10.1042/CS20110386
   Vrieze A, 2012, GASTROENTEROLOGY, V143, P913, DOI 10.1053/j.gastro.2012.06.031
   Wang DS, 2002, J PHARMACOL EXP THER, V302, P510, DOI 10.1124/jpet.102.034140
   Wang JH, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00620
   Wang JH, 2017, GENES-BASEL, V8, DOI 10.3390/genes8100239
   Wang K, 2019, CELL REP, V26, P222, DOI 10.1016/j.celrep.2018.12.028
   Wankhade UD, 2019, NUTRIENTS, V11, DOI 10.3390/nu11020313
   Watanabe M, 2011, J BIOL CHEM, V286, P26913, DOI 10.1074/jbc.M111.248203
   Weigert C, 2005, AM J PHYSIOL-ENDOC M, V289, pE251, DOI 10.1152/ajpendo.00448.2004
   Wen L, 2017, J NUTR, V147, p1468S, DOI 10.3945/jn.116.240754
   WILCOCK C, 1991, J PHARM PHARMACOL, V43, P442, DOI 10.1111/j.2042-7158.1991.tb03507.x
   WILCOCK C, 1994, XENOBIOTICA, V24, P49, DOI 10.3109/00498259409043220
   Winter SE, 2013, SCIENCE, V339, P708, DOI 10.1126/science.1232467
   Wu BN, 2011, J NUTR METAB, V2011, DOI 10.1155/2011/391809
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Wu TZ, 2017, EXPERT REV GASTROENT, V11, P157, DOI 10.1080/17474124.2017.1273769
   Xue J, 2019, ENDOCR J, V66, P859, DOI 10.1507/endocrj.EJ18-0567
   Yadav H, 2007, NUTRITION, V23, P62, DOI 10.1016/j.nut.2006.09.002
   Yang J, 2020, FRONT MICROBIOL, V11, DOI 10.3389/fmicb.2020.02029
   Zeuthen LH, 2006, CLIN VACCINE IMMUNOL, V13, P365, DOI 10.1128/CVI.13.3.365-375.2006
   Zhang FH, 2019, ENDOCRINE, V66, P485, DOI 10.1007/s12020-019-02041-5
   Zhang HS, 2015, ISME J, V9, P770, DOI 10.1038/ismej.2014.165
   Zhang MC, 2019, BMJ OPEN DIAB RES CA, V7, DOI 10.1136/bmjdrc-2019-000717
   Zhang Q, 2020, DIABET METAB SYND OB, V13, P5003, DOI 10.2147/DMSO.S286430
   Zhang W, 2019, BIOMED PHARMACOTHER, V118, DOI 10.1016/j.biopha.2019.109131
   Zhang XY, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0071108
   Zhang X, 2015, SCI REP-UK, V5, DOI 10.1038/srep14405
   Zhang YQ, 2006, P NATL ACAD SCI USA, V103, P1006, DOI 10.1073/pnas.0506982103
   Zheng JL, 2018, J AGR FOOD CHEM, V66, P5821, DOI [10.1021/acsjafc.8b00829, 10.1021/acs.jafc.8b00829]
   Zomorrodi AR, 2012, PLOS COMPUT BIOL, V8, DOI 10.1371/journal.pcbi.1002363
NR 204
TC 35
Z9 35
U1 3
U2 25
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD APR
PY 2021
VL 22
IS 7
AR 3566
DI 10.3390/ijms22073566
PG 26
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA RL0LA
UT WOS:000638674700001
PM 33808194
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Lee, H
   Kim, J
   An, JH
   Lee, S
   Choi, D
   Kong, H
   Song, Y
   Park, I
   Lee, CK
   Kim, K
AF Lee, Heetae
   Kim, Jiyeon
   An, Jinho
   Lee, Sungwon
   Choi, Dohyun
   Kong, Hyunseok
   Song, Youngcheon
   Park, Il Ho
   Lee, Chong-Kil
   Kim, Kyungjae
TI Downregulation of IL-18 Expression in the Gut by Metformin-induced Gut
   Microbiota Modulation
SO IMMUNE NETWORK
LA English
DT Article
DE IL-18; Metformin; Gut microbiota; Fecal microbiota transplantation;
   Toll-like receptors; GLP-1
ID IMPROVES METABOLIC PROFILES; AKKERMANSIA-MUCINIPHILA; INFLAMMATION;
   RESISTANCE
AB IL-18 is a crucial pro-inflammatory cytokine that mediates chronic intestinal inflammation. Metformin, an anti-diabetic drug, was reported to have ameliorative effects on inflammatory bowel disease. Recently, the mechanism of action of metformin was explained as a modulation of gut microbiota. In this study, fecal microbiota transplantation (FMT) using fecal material from metformin-treated mice was found to upregulate the expression of GLP-1 and pattern-recognition receptors TLR1 and TLR4 for the improvement in hyperglycemia caused by a high-fat diet. Further, FMT downregulated the expression of the inflammatory cytokine IL-18. Within the genera Akkermansia, Bacteroides, and Butyricimonas, which were promoted by metformin therapy, Butyricimonas was found to be consistently abundant following FMT. Our findings suggest that modulation of gut microbiota is a key factor for the anti-inflammatory effects of metformin which is used for the treatment of hyperglycemia.
C1 [Lee, Heetae; Kim, Jiyeon; An, Jinho; Lee, Sungwon; Choi, Dohyun; Kong, Hyunseok; Song, Youngcheon; Park, Il Ho; Kim, Kyungjae] Sahmyook Univ, Coll Pharm, 815 Hwarang Ro, Seoul 01795, South Korea.
   [Lee, Chong-Kil] Chungbuk Natl Univ, Coll Pharm, Cheongju 28644, South Korea.
C3 Sahmyook University; Chungbuk National University
RP Kim, K (通讯作者)，Sahmyook Univ, Coll Pharm, 815 Hwarang Ro, Seoul 01795, South Korea.
EM kimkj@syu.ac.kr
OI lee, heetae/0000-0001-5105-8841; Song, Youngcheon/0000-0002-4350-6330;
   Lee, Chong-Kil/0000-0001-9070-341X
FU Sahmyook University Research Fund [RI12019069 [2019]]
FX This study was supported by the Sahmyook University Research Fund
   (RI12019069 [2019]).
CR Berstein LM, 2012, AGING-US, V4, P320, DOI 10.18632/aging.100455
   Cameron AR, 2016, CIRC RES, V119, P652, DOI 10.1161/CIRCRESAHA.116.308445
   Carvalho BM, 2013, MEDIAT INFLAMM, V2013, DOI 10.1155/2013/986734
   Cornick S, 2015, TISSUE BARRIERS, V3, DOI 10.4161/21688370.2014.982426
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Grasset E, 2017, CELL METAB, V25, P1075, DOI 10.1016/j.cmet.2017.04.013
   Guan QD, 2017, MEDIAT INFLAMM, V2017, DOI 10.1155/2017/4810258
   Gupta S, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-07230-8
   Harrison OJ, 2015, MUCOSAL IMMUNOL, V8, P1226, DOI 10.1038/mi.2015.13
   Insuela DBR, 2017, EUR J PHARMACOL, V812, P64, DOI 10.1016/j.ejphar.2017.07.015
   Kamdar K, 2018, J IMMUNOL, V201, P230, DOI 10.4049/jimmunol.1701216
   Kamdar K, 2016, CELL HOST MICROBE, V19, P21, DOI 10.1016/j.chom.2015.12.006
   Kanai T, 2013, CURR DRUG TARGETS, V14, P1392, DOI 10.2174/13894501113149990006
   Kasai C, 2015, BMC GASTROENTEROL, V15, DOI 10.1186/s12876-015-0330-2
   Khoruts A, 2016, NAT REV GASTRO HEPAT, V13, DOI 10.1038/nrgastro.2016.98
   Kim F, 2007, CIRC RES, V100, P1589, DOI 10.1161/CIRCRESAHA.106.142851
   Lee H, 2018, GERONTOLOGIST, V58, P159, DOI 10.1093/geront/gnx050
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Lee HM, 2013, DIABETES, V62, P194, DOI 10.2337/db12-0420
   Lee SY, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0135858
   Lee YS, 2016, MEDIAT INFLAMM, V2016, DOI 10.1155/2016/3094642
   Li M, 2018, EUR J PHARMACOL, V831, P52, DOI 10.1016/j.ejphar.2018.05.003
   Lin HP, 2012, PLOS ONE, V7, DOI [10.1371/journal.pone.0031286, 10.1371/journal.pone.0035240]
   Mardinoglu A, 2016, CELL METAB, V23, P10, DOI 10.1016/j.cmet.2015.12.012
   Mirmonsef P, 2012, AM J REPROD IMMUNOL, V67, P391, DOI 10.1111/j.1600-0897.2011.01089.x
   Nagao-Kitamoto H, 2017, IMMUNE NETW, V17, P1, DOI 10.4110/in.2017.17.1.1
   Nowarski R, 2015, CELL, V163, P1444, DOI 10.1016/j.cell.2015.10.072
   Rios-Covian D, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.00376
   Sanz Y, 2015, PEDIATR RES, V77, P236, DOI 10.1038/pr.2014.170
   Schneeberger M, 2015, SCI REP-UK, V5, DOI 10.1038/srep16643
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Sivakumar PV, 2002, GUT, V50, P812, DOI 10.1136/gut.50.6.812
   Velloso LA, 2015, ENDOCR REV, V36, P245, DOI 10.1210/er.2014-1100
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Wu HJ, 2012, GUT MICROBES, V3, P4, DOI 10.4161/gmic.19320
   Zhang Q, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0184735
   Zhao SQ, 2017, J MOL ENDOCRINOL, V58, P1, DOI 10.1530/JME-16-0054
   Zietek T, 2016, FRONT IMMUNOL, V7, DOI 10.3389/fimmu.2016.00154
NR 38
TC 6
Z9 6
U1 0
U2 11
PU KOREA ASSOC IMMUNOLOGISTS
PI SEOUL
PA KOREA SCIENCE & TECHNOLOGY CENTER, RM 701, 7 GIL 22, TEHERAN-RO, (635-4
   YEOKSAM-DONG) GANGMAN-GU, SEOUL, 06130, SOUTH KOREA
SN 1598-2629
EI 2092-6685
J9 IMMUNE NETW
PD AUG
PY 2019
VL 19
IS 4
AR e28
DI 10.4110/in.2019.19.e28
PG 9
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA IV5XX
UT WOS:000484344600006
PM 31501716
OA Green Submitted, Green Published
DA 2023-06-08
ER

PT J
AU Sillner, N
   Walker, A
   Koch, W
   Witting, M
   Schmitt-Kopplin, P
AF Sillner, Nina
   Walker, Alesia
   Koch, Wendelin
   Witting, Michael
   Schmitt-Kopplin, Philippe
TI Metformin impacts cecal bile acid profiles in mice
SO JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL
   AND LIFE SCIENCES
LA English
DT Article
DE Bile acids; UHPLC-MS; Quantification; Metformin; db/db mice
ID HIGH-FAT DIET; SULFATE METABOLITES; MURICHOLIC ACID; MOUSE-LIVER; RAT;
   PLASMA; MICROBIOTA; GUT; URINE; HOMEOSTASIS
AB Bile acids (BAs) are major components of bile synthesized from cholesterol and take part in the digestion of dietary lipids, as well as having signaling functions. They undergo extensive microbial metabolism inside the gastrointestinal tract. Here, we present a method of ultra-high pressure liquid chromatography coupled to ion trap mass spectrometry for quantification of 45 BAs in mouse cecum. The system was validated in regard to sensitivity with limits of detection and quantification (0.6-24.9 nM), interday accuracy (102.4%), interday precision (15.2%), recovery rate (74.7%), matrix effect (98.2%) and carry-over effect ( < 1.1%). Afterwards, we applied our method to investigate the effect of metformin on BA profiles. Diabetic mice were treated with metformin for 1 day or 14 days. One day of treatment resulted in a significant increase of total BA concentration (2.7-fold increase; db/db metformin 5.32 mu mol/g, db/db control mice 1.95 mu mol/g), most notable in levels of 7oxodeoxycholic, 3-dehydrocholic and cholic acid. We observed only minor impact on BA metabolism after 14 days of metformin treatment, compared to the single treatment. Furthermore, healthy wild type mice had elevated concentrations of allocholic and omega-muricholic acid compared to diabetic mice. Our method proved the applicability of profiling BAs in cecum to investigate intestinal BA metabolism in diabetes and pharmacological applications.
C1 [Sillner, Nina; Schmitt-Kopplin, Philippe] Tech Univ Munich, ZIEL Inst Food & Hlth, Freising Weihenstephan, Germany.
   [Sillner, Nina; Walker, Alesia; Koch, Wendelin; Witting, Michael; Schmitt-Kopplin, Philippe] Helmholtz Zentrum Munchen, Res Unit Analyt BioGeoChem, Neuherberg, Germany.
   [Witting, Michael; Schmitt-Kopplin, Philippe] Tech Univ Munich, Chair Analyt Food Chem, Freising Weihenstephan, Germany.
C3 Technical University of Munich; Helmholtz Association; Helmholtz-Center
   Munich - German Research Center for Environmental Health; Technical
   University of Munich
RP Walker, A (通讯作者)，HelmholtzZentrum Munchen, Deutsch Forschungszentrum Gesundheit & Umwelt, Dept Environm Sci, Analyt BioGeoChem, Ingolstaedter Landstr 1, D-85764 Neuherberg, Germany.
EM alesia.walker@helmholtz-muenchen.de
RI Schmitt-Kopplin, Philippe/H-6271-2011; Witting, Michael/AAI-1338-2019
OI Schmitt-Kopplin, Philippe/0000-0003-0824-2664; Witting,
   Michael/0000-0002-1462-4426; Walker, Alesia/0000-0002-1477-2023
FU Deutsche Forschungsgemeinschaft (SPP1656); ZIEL Institute for Food AMP;
   Health, Technical University of Munich; German Center for Diabetes
   Research (DZD); Ministry of Education and Research of the Federal
   Republic of Germany (BMBF) [0315494A]
FX The authors thank Deutsche Forschungsgemeinschaft (SPP1656) and ZIEL
   Institute for Food & Health, Technical University of Munich for the
   financial support of the work. The project was funded by the German
   Center for Diabetes Research (DZD) and the Ministry of Education and
   Research of the Federal Republic of Germany (BMBF) under project no.
   0315494A (SysMBo - Systems Biology of Metabotypes).
CR Alnouti Y, 2008, J CHROMATOGR B, V873, P209, DOI 10.1016/j.jchromb.2008.08.018
   Bathena SPR, 2013, J CHROMATOGR B, V942, P53, DOI 10.1016/j.jchromb.2013.10.019
   Benson RSP, 2002, J PHYSIOL-LONDON, V538, P121, DOI 10.1113/jphysiol.2001.012969
   Cariou B, 2011, NUTR METAB, V8, DOI 10.1186/1743-7075-8-48
   Carter D, 2003, DIABETES OBES METAB, V5, P120, DOI 10.1046/j.1463-1326.2003.00252.x
   Chen C, 2016, J PHARMACEUT BIOMED, V131, P473, DOI 10.1016/j.jpba.2016.09.023
   Chen Q, 2017, BBA-MOL CELL RES, V1864, P101, DOI 10.1016/j.bbamcr.2016.10.020
   Devlin AS, 2015, NAT CHEM BIOL, V11, P685, DOI [10.1038/NCHEMBIO.1864, 10.1038/nchembio.1864]
   Fiorucci S, 2015, TRENDS MOL MED, V21, P702, DOI 10.1016/j.molmed.2015.09.001
   Garcia-Canaveras JC, 2012, J LIPID RES, V53, P2231, DOI 10.1194/jlr.D028803
   Griffiths WJ, 2010, J LIPID RES, V51, P23, DOI 10.1194/jlr.R001941-JLR200
   Haeusler RA, 2013, DIABETES, V62, P4184, DOI 10.2337/db13-0639
   Han J, 2015, ANAL CHEM, V87, P1127, DOI 10.1021/ac503816u
   Han KH, 2013, DIGEST DIS SCI, V58, P2177, DOI 10.1007/s10620-013-2631-z
   Huang JG, 2011, J PHARMACEUT BIOMED, V55, P1111, DOI 10.1016/j.jpba.2011.03.035
   Jantti SE, 2014, ANAL BIOANAL CHEM, V406, P7799, DOI 10.1007/s00216-014-8230-9
   Kanauchi O, 2003, J GASTROENTEROL, V38, P134, DOI 10.1007/s005350300022
   Kubeck R, 2016, MOL METAB, V5, P1162, DOI 10.1016/j.molmet.2016.10.001
   Kumar RS, 2006, J BIOL CHEM, V281, P32516, DOI 10.1074/jbc.M604172200
   Kuo SM, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0060270
   Lee G, 2016, J CHROMATOGR B, V1031, P37, DOI 10.1016/j.jchromb.2016.07.017
   Liu Y, 2016, RSC ADV, V6, P81826, DOI 10.1039/c6ra13272c
   Minato K, 2015, J CHROMATOGR B, V1002, P399, DOI 10.1016/j.jchromb.2015.08.047
   Murakami Y, 2016, J FOOD SCI, V81, pH216, DOI 10.1111/1750-3841.13166
   Narushima S, 2000, LIPIDS, V35, P639, DOI 10.1007/s11745-000-0568-0
   Narushima S, 1999, MICROBIOL IMMUNOL, V43, P893, DOI 10.1111/j.1348-0421.1999.tb01224.x
   Neschen S, 2015, DIABETES, V64, P284, DOI 10.2337/db14-0393
   OGLE D.H., 2017, FSA FISHERIES STOCK
   Pandak WM, 2001, GASTROENTEROLOGY, V120, P1801, DOI 10.1053/gast.2001.24833
   Parolini C, 2012, LIVER INT, V32, P1363, DOI 10.1111/j.1478-3231.2012.02855.x
   Parseus A, 2017, GUT, V66, P429, DOI 10.1136/gutjnl-2015-310283
   Pham HT, 2016, J APPL LAB MED, V1, P129, DOI 10.1373/jalm.2016.020537
   Ridlon JM, 2006, J LIPID RES, V47, P241, DOI 10.1194/jlr.R500013-JLR200
   SACQUET EC, 1979, APPL ENVIRON MICROB, V37, P1127, DOI 10.1128/AEM.37.6.1127-1131.1979
   Sarafian MH, 2015, ANAL CHEM, V87, P9662, DOI 10.1021/acs.analchem.5b01556
   Sayin SI, 2013, CELL METAB, V17, P225, DOI 10.1016/j.cmet.2013.01.003
   Scarpello JHB, 1998, DIABETIC MED, V15, P651, DOI 10.1002/(SICI)1096-9136(199808)15:8<651::AID-DIA628>3.0.CO;2-A
   Shiffka SJ, 2017, BBA-BIOMEMBRANES, V1859, P2269, DOI 10.1016/j.bbamem.2017.08.019
   Sonne DP, 2016, J CLIN ENDOCR METAB, V101, P3002, DOI 10.1210/jc.2016-1607
   Studer N, 2016, FRONT CELL INFECT MI, V6, DOI 10.3389/fcimb.2016.00191
   Suzuki Y, 2013, NAGOYA J MED SCI, V75, P57
   Takahashi S, 2016, J LIPID RES, V57, P2130, DOI 10.1194/jlr.M071183
   Takemura N, 2010, J NUTR, V140, P1963, DOI 10.3945/jn.110.128082
   Taylor DR, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0093540
   TOMKIN GH, 1976, IRISH J MED SCI, V145, P340, DOI 10.1007/BF02938968
   UCHIDA K, 1985, DIABETES, V34, P79, DOI 10.2337/diabetes.34.1.79
   Vallim TQD, 2013, CELL METAB, V17, P657, DOI 10.1016/j.cmet.2013.03.013
   Vincent RP, 2013, ANN CLIN BIOCHEM, V50, P360, DOI 10.1177/0004563212473450
   Walker A, 2014, J PROTEOME RES, V13, P4220, DOI 10.1021/pr500046b
   Want EJ, 2010, ANAL CHEM, V82, P5282, DOI 10.1021/ac1007078
   Wewalka M, 2014, J CLIN ENDOCR METAB, V99, P1442, DOI 10.1210/jc.2013-3367
   Wickham H, 2009, USE R, P1, DOI 10.1007/978-0-387-98141-3
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Xie GX, 2013, FASEB J, V27, P3583, DOI 10.1096/fj.13-231860
   YAMASAKI K, 1972, J BIOCHEM-TOKYO, V71, P927, DOI 10.1093/oxfordjournals.jbchem.a129848
   Yin SS, 2017, ANAL BIOANAL CHEM, V409, P5533, DOI 10.1007/s00216-017-0489-1
   Zhang LM, 2015, ENVIRON HEALTH PERSP, V123, P679, DOI 10.1289/ehp.1409055
NR 57
TC 7
Z9 8
U1 1
U2 21
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1570-0232
EI 1873-376X
J9 J CHROMATOGR B
JI J. Chromatogr. B
PD APR 15
PY 2018
VL 1083
BP 35
EP 43
DI 10.1016/j.jchromb.2018.02.029
PG 9
WC Biochemical Research Methods; Chemistry, Analytical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA GD8ME
UT WOS:000430765700005
PM 29522956
DA 2023-06-08
ER

PT J
AU Luo, C
   Wang, X
   Huang, HX
   Mao, XY
   Zhou, HH
   Liu, ZQ
AF Luo, Chao
   Wang, Xu
   Huang, Han-Xue
   Mao, Xiao-Yuan
   Zhou, Hong-Hao
   Liu, Zhao-Qian
TI Coadministration of metformin prevents olanzapine-induced metabolic
   dysfunction and regulates the gut-liver axis in rats
SO PSYCHOPHARMACOLOGY
LA English
DT Article
DE Metformin; Olanzapine; Metabolic dysfunction; Gut-liver axis; Gut
   microbiota
ID INDUCED WEIGHT-GAIN; POTENTIAL ROLE; SCHIZOPHRENIA; OBESITY;
   SENSITIVITY; MICROBIOME; ALTERS; SAFETY; DRUGS
AB Objective Olanzapine is widely prescribed for patients with mental disorders; however, it may induce metabolic dysfunction. Metformin is an efficient adjuvant for preventing olanzapine-induced metabolic dysfunction in clinical practice. Although the mechanism of how metformin prevents this metabolic dysfunction remains unknown, changes in the gut-liver axis are considered a potential explanation. Methods Forty-eight male rats were gavaged with olanzapine and/or metformin for 35 consecutive days. Body weight, food intake, and water intake were measured daily. Histopathological and biochemical tests were performed to evaluate the metabolic dysfunction. The 16S rRNA obtained from fecal bacterial DNA was assessed. Results Olanzapine treatment increased the body weight, blood glucose and triglyceride levels, and the number of adipocytes in the liver. While coadministration of metformin, there was a dose-dependent reverse of the abnormal changes induced by olanzapine treatment. Both olanzapine and metformin treatments altered the composition of the gut microbiota. Bacteroides acidifaciens and Lactobacillus gasseri were possibly played a positive role in metformin-mediated olanzapine-induced metabolic dysfunction prevention. Conclusion Metformin prevented olanzapine-induced metabolic dysfunction and regulated the gut microbiota in a dose-dependent manner.
C1 [Luo, Chao; Wang, Xu; Huang, Han-Xue; Mao, Xiao-Yuan; Zhou, Hong-Hao; Liu, Zhao-Qian] Cent South Univ, Xiangya Hosp, Dept Clin Pharmacol, Changsha 410008, Peoples R China.
   [Luo, Chao; Wang, Xu; Huang, Han-Xue; Mao, Xiao-Yuan; Zhou, Hong-Hao; Liu, Zhao-Qian] Cent South Univ, Hunan Key Lab Pharmacogenet, Inst Clin Pharmacol, Changsha 410078, Peoples R China.
   [Luo, Chao] Cent South Univ, Sch Life Sci, Changsha 410078, Hunan, Peoples R China.
C3 Central South University; Central South University; Central South
   University
RP Liu, ZQ (通讯作者)，Cent South Univ, Xiangya Hosp, Dept Clin Pharmacol, Changsha 410008, Peoples R China.; Liu, ZQ (通讯作者)，Cent South Univ, Hunan Key Lab Pharmacogenet, Inst Clin Pharmacol, Changsha 410078, Peoples R China.
EM zqliu@csu.edu.cn
RI Luo, Chao/GQH-1910-2022
OI Luo, Chao/0000-0002-7007-1440; Liu, Zhaoqian/0000-0003-0428-3928
FU National Key Research and Development Program of China [2016YFC1306900];
   National Natural Science Foundation of China [81573508, 81874327];
   Strategy-Oriented Special Project of Central South University in China
   [ZLXD2017003]
FX This work was supported by the National Key Research and Development
   Program of China (2016YFC1306900), National Natural Science Foundation
   of China (81573508, 81874327), and The Strategy-Oriented Special Project
   of Central South University in China (ZLXD2017003).
CR Albillos A, 2020, J HEPATOL, V72, P558, DOI 10.1016/j.jhep.2019.10.003
   Bai ZH, 2017, SCHIZOPHR RES, V185, P73, DOI 10.1016/j.schres.2017.01.002
   Bauer PV, 2018, CELL METAB, V27, P572, DOI 10.1016/j.cmet.2018.01.013
   Boyda HN, 2014, PROG NEURO-PSYCHOPH, V48, P170, DOI 10.1016/j.pnpbp.2013.10.006
   Boyda HN, 2012, J PSYCHIATR NEUROSCI, V37, P407, DOI 10.1503/jpn.110140
   Caporaso JG, 2010, NAT METHODS, V7, P335, DOI 10.1038/nmeth.f.303
   Chen CH, 2018, CELL PHYSIOL BIOCHEM, V50, P1216, DOI 10.1159/000494573
   Davey KJ, 2013, TRANSL PSYCHIAT, V3, DOI 10.1038/tp.2013.83
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Edgar RC, 2013, NAT METHODS, V10, P996, DOI [10.1038/nmeth.2604, 10.1038/NMETH.2604]
   Edgar RC, 2011, BIOINFORMATICS, V27, P2194, DOI 10.1093/bioinformatics/btr381
   Elbere I, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0204317
   Endo S, 2019, J GEN APPL MICROBIOL, V65, P47, DOI 10.2323/jgam.2018.05.001
   Flank J, 2014, DRUG SAFETY, V37, P791, DOI 10.1007/s40264-014-0219-y
   Flowers SA, 2019, PHARMACOTHERAPY, V39, P161, DOI 10.1002/phar.2214
   Howell JJ, 2017, CELL METAB, V25, P463, DOI 10.1016/j.cmet.2016.12.009
   Hu Y, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0092099
   Huhn M, 2019, LANCET, V394, P939, DOI [10.1016/S0140-6736(19)31135-3, 10.1176/appi.focus.18306]
   Ikegami M, 2013, DIABETES OBES METAB, V15, P1128, DOI 10.1111/dom.12148
   Ji Y, 2017, CHEM-BIOL INTERACT, V276, P113, DOI 10.1016/j.cbi.2017.03.002
   Kao ACC, 2018, TRANSL PSYCHIAT, V8, DOI 10.1038/s41398-018-0116-8
   Klopper KB, 2018, PROBIOTICS ANTIMICRO, V10, P89, DOI 10.1007/s12602-017-9307-5
   Lecomte V, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0126931
   Li Q, 2015, AUST NZ J PSYCHIAT, V49, P129, DOI 10.1177/0004867414536931
   Luo C, 2020, PSYCHOPHARMACOLOGY, V237, P2257, DOI 10.1007/s00213-020-05524-w
   Luo C, 2019, FRONT PHARMACOL, V10, DOI 10.3389/fphar.2019.00371
   Luo C, 2019, NEUROSCI BULL, V35, P561, DOI 10.1007/s12264-018-0323-6
   Ma W, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.01336
   Manu P, 2015, ACTA PSYCHIAT SCAND, V132, P97, DOI 10.1111/acps.12445
   Martin M., 2011, EMBNET J, V17, P10, DOI DOI 10.14806/EJ.17.1.200
   Mayer EA, 2015, J CLIN INVEST, V125, P926, DOI 10.1172/JCI76304
   Morgan AP, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0115225
   Palau-Rodriguez M, 2015, FRONT MICROBIOL, V6, DOI [10.3339/fmicb.2075.07751, 10.3389/fmicb.2015.01151]
   Parks DH, 2014, BIOINFORMATICS, V30, P3123, DOI 10.1093/bioinformatics/btu494
   Pellock SJ, 2018, J BIOL CHEM, V293, P18559, DOI 10.1074/jbc.RA118.005414
   Praharaj SK, 2011, BRIT J CLIN PHARMACO, V71, P377, DOI 10.1111/j.1365-2125.2010.03783.x
   Ren LY, 2019, LIFE SCI, V217, P229, DOI 10.1016/j.lfs.2018.12.015
   Sandhu KV, 2017, TRANSL RES, V179, P223, DOI 10.1016/j.trsl.2016.10.002
   Schloss PD, 2009, APPL ENVIRON MICROB, V75, P7537, DOI 10.1128/AEM.01541-09
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Skonieczna-Zydecka K, 2019, PSYCHOPHARMACOLOGY, V236, P1491, DOI 10.1007/s00213-018-5102-6
   Tripathi A, 2018, NAT REV GASTRO HEPAT, V15, P397, DOI 10.1038/s41575-018-0011-z
   Werner FM, 2014, EXPERT OPIN DRUG SAF, V13, P1031, DOI 10.1517/14740338.2014.935761
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Wu RR, 2016, MOL PSYCHIATR, V21, P1537, DOI 10.1038/mp.2015.221
   Wu RR, 2008, JAMA-J AM MED ASSOC, V299, P185, DOI 10.1001/jama.2007.56-b
   Wu RR, 2012, AM J PSYCHIAT, V169, P813, DOI 10.1176/appi.ajp.2012.11091432
   Yang JY, 2017, MUCOSAL IMMUNOL, V10, P104, DOI 10.1038/mi.2016.42
   Yarza P, 2014, NAT REV MICROBIOL, V12, P635, DOI 10.1038/nrmicro3330
NR 49
TC 6
Z9 7
U1 3
U2 14
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0033-3158
EI 1432-2072
J9 PSYCHOPHARMACOLOGY
JI Psychopharmacology
PD JAN
PY 2021
VL 238
IS 1
BP 239
EP 248
DI 10.1007/s00213-020-05677-8
EA OCT 2020
PG 10
WC Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA SF2CO
UT WOS:000582092500001
PM 33095288
DA 2023-06-08
ER

PT J
AU Pollak, M
AF Pollak, Michael
TI The effects of metformin on gut microbiota and the immune system as
   research frontiers
SO DIABETOLOGIA
LA English
DT Review
DE Diabetes; Metformin; Microbiome; Microbiota immunity cancer
ID PANCREATIC-CANCER; COMPLEX I; AMPK; PREVENTION; OBESITY; HYPERGLYCEMIA;
   MECHANISMS; BIGUANIDES; METAGENOME; TARGET
AB Recent studies have revealed that metformin influences gut microbiota and the immune system although neither is a classic target of the drug. This research has revealed complexity not previously appreciated, and opened new research directions. The extent to which immunomodulatory effects and actions on the microbiota are related to each other and account for effects on host energy metabolism remains to be determined. These sites of action may be relevant not only to the efficacy of metformin for its established use in type 2 diabetes, but also to proposed novel indications in oncology and other diseases.
C1 [Pollak, Michael] McGill Univ, Dept Oncol, Div Canc Prevent, Montreal, PQ H3T 1E2, Canada.
C3 McGill University
RP Pollak, M (通讯作者)，McGill Univ, Dept Oncol, Div Canc Prevent, Montreal, PQ H3T 1E2, Canada.
EM michael.pollak@mcgill.ca
RI Pollak, Michael N/G-9094-2011
OI Pollak, Michael N/0000-0003-3047-0604
CR An HY, 2016, J ENDOCRINOL, V228, pR97, DOI 10.1530/JOE-15-0447
   Andrzejewski S, 2014, CANCER METAB, V2, DOI 10.1186/2049-3002-2-12
   Bailey CJ, 2017, DIABETOLOGIA, V60, P1566, DOI 10.1007/s00125-017-4318-z
   Barzilai N, 2016, CELL METAB, V23, P1060, DOI 10.1016/j.cmet.2016.05.011
   Blagih J, 2015, IMMUNITY, V42, P41, DOI 10.1016/j.immuni.2014.12.030
   Bridges HR, 2016, BMC BIOL, V14, DOI 10.1186/s12915-016-0287-9
   Bridges HR, 2014, BIOCHEM J, V462, P475, DOI 10.1042/BJ20140620
   Brunkwall L, 2017, DIABETOLOGIA, V60, P943, DOI 10.1007/s00125-017-4278-3
   Buse JB, 2016, DIABETES CARE, V39, P198, DOI 10.2337/dc15-0488
   Cabreiro F, 2013, CELL, V153, P228, DOI 10.1016/j.cell.2013.02.035
   Cameron AR, 2016, CIRC RES, V119, P652, DOI 10.1161/CIRCRESAHA.116.308445
   Chandel NS, 2016, CELL METAB, V23, P569, DOI 10.1016/j.cmet.2016.03.010
   Cheng SC, 2014, SCIENCE, V345, P1579, DOI 10.1126/science.1250684
   Duca FA, 2015, NAT MED, V21, P506, DOI 10.1038/nm.3787
   Eikawa S, 2015, P NATL ACAD SCI USA, V112, P1809, DOI 10.1073/pnas.1417636112
   Foretz M, 2014, CELL METAB, V20, P953, DOI 10.1016/j.cmet.2014.09.018
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Goldberg RB, 2014, DIABETES CARE, V37, P2253, DOI 10.2337/dc13-2471
   Grasset E, 2017, CELL METAB, V25, P1075, DOI 10.1016/j.cmet.2017.04.013
   Gui DY, 2016, CELL METAB, V24, P716, DOI 10.1016/j.cmet.2016.09.006
   Hirsch HA, 2013, P NATL ACAD SCI USA, V110, P972, DOI 10.1073/pnas.1221055110
   Howell JJ, 2017, CELL METAB, V25, P463, DOI 10.1016/j.cmet.2016.12.009
   JALLING O, 1984, ACTA PHARMACOL TOX, V54, P327
   Kalender A, 2010, CELL METAB, V11, P390, DOI 10.1016/j.cmet.2010.03.014
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kim SH, 2017, J INVEST DERMATOL, V137, P1740, DOI 10.1016/j.jid.2017.03.033
   Klil-Drori AJ, 2017, NAT REV CLIN ONCOL, V14, P85, DOI 10.1038/nrclinonc.2016.120
   Komaroff AL, 2017, JAMA-J AM MED ASSOC, V317, P355, DOI 10.1001/jama.2016.20099
   Kordes S, 2015, LANCET ONCOL, V16, P839, DOI 10.1016/S1470-2045(15)00027-3
   Lee SY, 2017, J IMMUNOL, V198, P2661, DOI 10.4049/jimmunol.1403088
   Liang XM, 2017, J PHARM SCI-US, V106, P2245, DOI 10.1016/j.xphs.2017.04.078
   Madiraju AK, 2014, NATURE, V510, P542, DOI 10.1038/nature13270
   Martin-Montalvo A, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms3192
   McCreight LJ, 2016, DIABETOLOGIA, V59, P426, DOI 10.1007/s00125-015-3844-9
   Moiseeva O, 2013, AGING CELL, V12, P489, DOI 10.1111/acel.12075
   Negrotto L, 2016, JAMA NEUROL, V73, P520, DOI 10.1001/jamaneurol.2015.4807
   Pearce EL, 2009, NATURE, V460, P103, DOI 10.1038/nature08097
   Pedersen HK, 2016, NATURE, V535, P376, DOI 10.1038/nature18646
   Perry RJ, 2016, NATURE, V534, P213, DOI 10.1038/nature18309
   Pollak M, 2012, CLIN CANCER RES, V18, P2723, DOI 10.1158/1078-0432.CCR-12-0694
   Pollak MN, 2012, CANCER DISCOV, V2, P778, DOI 10.1158/2159-8290.CD-12-0263
   Pryor R, 2015, BIOCHEM J, V471, P307, DOI 10.1042/BJ20150497
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Rajeshkumar NV, 2017, CLIN CANCER RES, V23, P5639, DOI 10.1158/1078-0432.CCR-17-1115
   Scharping NE, 2017, CANCER IMMUNOL RES, V5, P9, DOI 10.1158/2326-6066.CIR-16-0103
   Singhal A, 2014, SCI TRANSL MED, V6, DOI 10.1126/scitranslmed.3009885
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Wang PY, 2017, J CLIN INVEST, V127, P132, DOI 10.1172/JCI88668
   WEINBERG ED, 1968, ANN NY ACAD SCI, V148, P587, DOI 10.1111/j.1749-6632.1968.tb27733.x
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Yin YM, 2015, SCI TRANSL MED, V7, DOI 10.1126/scitranslmed.aaa0835
   Zmora N, 2017, CELL METAB, V25, P506, DOI 10.1016/j.cmet.2017.02.006
NR 52
TC 59
Z9 64
U1 1
U2 37
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0012-186X
EI 1432-0428
J9 DIABETOLOGIA
JI Diabetologia
PD SEP
PY 2017
VL 60
IS 9
BP 1662
EP 1667
DI 10.1007/s00125-017-4352-x
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA FD3QE
UT WOS:000407446700013
PM 28770326
OA Bronze
DA 2023-06-08
ER

PT J
AU El-Baz, AM
   Shata, A
   Hassan, HM
   El-Sokkary, MMA
   Khodir, AE
AF El-Baz, Ahmed M.
   Shata, Ahmed
   Hassan, Hanan M.
   El-Sokkary, Mohamed M. A.
   Khodir, Ahmed E.
TI The therapeutic role of lactobacillus and montelukast in combination
   with metformin in diabetes mellitus complications through modulation of
   gut microbiota and suppression of oxidative stress
SO INTERNATIONAL IMMUNOPHARMACOLOGY
LA English
DT Article
DE Metformin; Montelukast; Lactobacillus; Diabetes mellitus; Testes; Gut
   microbiota
ID ANTIOXIDANT ENZYMES; RENAL DAMAGE; INJURY; GLUTATHIONE; PROTECTS;
   DISEASE; CELLS; LIVER; MICE; AXIS
AB Male reproductive dysfunction is one of the overlooked findings of diabetes mellitus (DM) that deserves greater scientific attention. This study is designed to explore the therapeutic potential of metformin and montelukast, in combination with Lactobacillus, for modulation of intestinal flora and suppression of oxidative stress in testicular and liver damage in diabetic male rats. A DM model was induced by streptozotocin (STZ)which caused functional, biochemical, and inflammatory injuries to the testicular and liver tissues. The experimental panel included nine rat groups: normal control, normal control plus metformin, normal control plus montelukast, DM control, DM plus montelukast, DM plus a combination of metformin and Lactobacillus, DM plus a combination of montelukast and Lactobacillus, and DM plus a combination of metformin and montelukast. In parallel, clinical evaluation of microscopic examination scoring, and hepatic and testicular injuries, were evaluated. Biochemical markers including glucose level, lipid profile, inflammatory markers (tumor necrosis factor- (TNF-alpha) and interleukin-17 (IL-17), Caspase-3, and Bax proteins expressions were measured. The change in the microbiota abundance was investigated using conventional and real-time PCR. The current study revealed a significant difference in the relative abundance of microbiota, where DM is associated with an enormous increase of Bacteroides spp., Clostridium spp., E. coli, and Fusobacterium spp., and a significant decrease in Bifidobacteria spp., and Lactobacillus spp., in contrast with normal control. Metformin and montelukast, in combination with Lactobacillus, significantly reversed the testicular and liver damage caused by STZ. Moreover, the drugs significantly reduced the oxidative, inflammatory, and apoptotic activities induced by STZ.
C1 [El-Baz, Ahmed M.] Delta Univ Sci & Technol, Microbiol & Biotechnol Dept, Fac Pharm, Gamasa 11152, Egypt.
   [Shata, Ahmed] Mansoura Univ, Dept Clin Pharmacol, Fac Med, Mansoura 35516, Egypt.
   [Shata, Ahmed] Delta Univ Sci & Technol, Dept Clin Pharm, Fac Pharm, Gamasa 11152, Egypt.
   [Hassan, Hanan M.] Delta Univ Sci & Technol, Pharmacol & Biochem Dept, Fac Pharm, Gamasa 11152, Egypt.
   [El-Sokkary, Mohamed M. A.] Mansoura Univ, Dept Microbiol, Fac Pharm, Mansoura 35516, Egypt.
   [Khodir, Ahmed E.] Horus Univ Egypt, Dept Pharmacol, Fac Pharm, New Damietta 34518, Egypt.
C3 Delta University for Science & Technology; Egyptian Knowledge Bank
   (EKB); Mansoura University; Delta University for Science & Technology;
   Delta University for Science & Technology; Egyptian Knowledge Bank
   (EKB); Mansoura University
RP El-Baz, AM (通讯作者)，Delta Univ Sci & Technol, Microbiol & Biotechnol Dept, Fac Pharm, Gamasa 11152, Egypt.
EM ahmed.elbaz@deltauniv.edu.eg
RI El-Baz, Ahmed/GOH-1625-2022; El-Baz, Ahmed/ABX-0695-2022
OI El-Baz, Ahmed/0000-0002-7290-6907; Khodir, Ahmed/0000-0002-5971-0838;
   El-Sokkary, Mohamed Mohamed Adel/0000-0003-2479-3984
CR Al Bataineh M.T., 2020, SCI REP-UK, V10, P1
   Al Bataineh MT, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-66598-2
   Allin KH, 2015, EUR J ENDOCRINOL, V172, pR167, DOI 10.1530/EJE-14-0874
   Arora S., 2009, GLOBAL J PHARM, V3, P81
   Azad MA, 2018, BIOMED RES INT, V2018, DOI 10.1155/2018/9478630
   Bagarolli RA, 2017, J NUTR BIOCHEM, V50, P16, DOI 10.1016/j.jnutbio.2017.08.006
   Ballester J, 2004, J ANDROL, V25, P706
   Beytur A, 2012, RENAL FAILURE, V34, P343, DOI 10.3109/0886022X.2011.647305
   Birkeland E., 2020, EUR J NUTR
   Carter CJ, 2017, FRONT AGING NEUROSCI, V9, DOI 10.3389/fnagi.2017.00408
   Chawla Aastha, 2016, Indian J Endocrinol Metab, V20, P546, DOI 10.4103/2230-8210.183480
   Chen CC, 2008, J ETHNOPHARMACOL, V117, P483, DOI 10.1016/j.jep.2008.02.032
   Claiborne A., 1985, HDB METHODS OXYGEN R
   Conde-Estevez D, 2011, EUR J CLIN MICROBIOL, V30, P103, DOI 10.1007/s10096-010-1029-5
   Coskun AK, 2011, THESCIENTIFICWORLDJO, V11, P1341, DOI 10.1100/tsw.2011.122
   Cuciureanu M, 2009, PROSTAG OTH LIPID M, V88, P82, DOI 10.1016/j.prostaglandins.2008.10.004
   Dallal M.M.S., 2015, JUNDISHAPUR J MICROB, V8
   Ding N, 2020, GUT, V69, P1608, DOI 10.1136/gutjnl-2019-319127
   Ejtahed HS, 2012, NUTRITION, V28, P539, DOI 10.1016/j.nut.2011.08.013
   El-Baz AM, 2020, LIFE SCI, V256, DOI 10.1016/j.lfs.2020.117927
   Fassati P, 1982, J CLIN CHEM CLIN BIO, V28, P2077
   Felizardo RJF, 2019, PHARMACOL RES, V141, P366, DOI 10.1016/j.phrs.2019.01.019
   Foretz M, 2019, NAT REV ENDOCRINOL, V15, P569, DOI 10.1038/s41574-019-0242-2
   Forouzandeh H., 2020, INT MED J, V27
   Garcia-Castillo V, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.01376
   Grigorescu I, 2016, ACTA ENDOCRINOL-BUCH, V12, P206, DOI 10.4183/aeb.2016.206
   Guneli E, 2008, EUR SURG RES, V40, P354, DOI 10.1159/000118032
   Gurung M, 2020, EBIOMEDICINE, V51, DOI 10.1016/j.ebiom.2019.11.051
   Han YPW, 2015, CURR OPIN MICROBIOL, V23, P141, DOI 10.1016/j.mib.2014.11.013
   Hersoug LG, 2016, OBES REV, V17, P297, DOI 10.1111/obr.12370
   Hisalkar PJ., 2012, BIOL MED, V4, P65
   Honda K, 2016, NATURE, V535, P75, DOI 10.1038/nature18848
   Hsieh FC, 2013, NUTR METAB, V10, DOI 10.1186/1743-7075-10-35
   Hu XF, 2020, BMC NEPHROL, V21, DOI 10.1186/s12882-020-01741-9
   Karasu Cimen, 2010, Open Cardiovasc Med J, V4, P240, DOI 10.2174/1874192401004010240
   Khamis T, 2020, BBA-MOL BASIS DIS, V1866, DOI 10.1016/j.bbadis.2019.165577
   Khodir AE, 2016, HUM EXP TOXICOL, V35, P388, DOI 10.1177/0960327115591372
   Khodir AE, 2014, CAN J PHYSIOL PHARM, V92, P839, DOI 10.1139/cjpp-2014-0191
   Kose E, 2012, SCI WORLD J, DOI 10.1100/2012/987508
   Lai TT, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9080729
   Li Q, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-62224-3
   Long LL, 2018, ONCOTARGET, V9, P5321, DOI 10.18632/oncotarget.23915
   Menni C, 2020, GUT MICROBES, V11, P1632, DOI 10.1080/19490976.2020.1778261
   Mohamadin Ahmed M, 2011, Pathophysiology, V18, P235, DOI 10.1016/j.pathophys.2011.02.003
   Mushtaq N, 2019, INT J MOL MED, V44, P513, DOI 10.3892/ijmm.2019.4235
   Ochoa-Reparaz J, 2016, CURR OBES REP, V5, P51, DOI 10.1007/s13679-016-0191-1
   PAGLIA DE, 1967, J LAB CLIN MED, V70, P158
   Porras D, 2017, FREE RADICAL BIO MED, V102, P188, DOI 10.1016/j.freeradbiomed.2016.11.037
   Rodriguez J., 2020, GUT
   Saber S, 2020, CANCER CHEMOTH PHARM, V85, P331, DOI 10.1007/s00280-020-04033-z
   Salgaco MK, 2019, APPL MICROBIOL BIOT, V103, P9229, DOI 10.1007/s00253-019-10156-y
   Schoeller EL, 2012, DIABETES, V61, P1869, DOI 10.2337/db11-1527
   Sener G, 2005, BURNS, V31, P587, DOI 10.1016/j.burns.2005.01.012
   Sharma S, 2019, J NUTR BIOCHEM, V63, P101, DOI 10.1016/j.jnutbio.2018.10.003
   Soni LK, 2018, BIOMED PHARMACOTHER, V108, P1015, DOI 10.1016/j.biopha.2018.09.099
   Sugiyama S, 2011, J CLIN BIOCHEM NUTR
   Sultuybek GK, 2019, CLIN EXP PHARMACOL P, V46, P413, DOI 10.1111/1440-1681.13073
   Tabuchi M, 2003, BIOSCI BIOTECH BIOCH, V67, P1421, DOI 10.1271/bbb.67.1421
   Tietz N.W., 1976, FUNDAMENTAL CLIN CHE
   TIETZE F, 1969, ANAL BIOCHEM, V27, P502, DOI 10.1016/0003-2697(69)90064-5
   Trinder P, 1969, ANNALS CLINICAL BIOC, V6, P24, DOI DOI 10.1177/000456326900600108
   Tugtepe H, 2007, EUR J PHARMACOL, V557, P69, DOI 10.1016/j.ejphar.2006.11.009
   van Deventer CA, 2015, J AM SOC HYPERTENS, V9, P104, DOI 10.1016/j.jash.2014.11.007
   Vemuri R, 2018, NUTRIENTS, V10, DOI 10.3390/nu10091255
   Wang FZ, 2005, J PLANT PHYSIOL, V162, P465, DOI 10.1016/j.jplph.2004.09.009
   Wong SH, 2017, GUT, V66, P1441, DOI 10.1136/gutjnl-2016-312766
   Wu GD, 2016, GUT, V65, P63, DOI 10.1136/gutjnl-2014-308209
   Yan FF, 2019, FOOD FUNCT, V10, P5804, DOI 10.1039/c9fo01062a
   Zemjanis R, 1970, DIAGNOSTIC THERAPEUT, V2, P467
NR 69
TC 12
Z9 12
U1 0
U2 16
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1567-5769
EI 1878-1705
J9 INT IMMUNOPHARMACOL
JI Int. Immunopharmacol.
PD JUL
PY 2021
VL 96
AR 107757
DI 10.1016/j.intimp.2021.107757
EA MAY 2021
PG 22
WC Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Pharmacology & Pharmacy
GA SW0FH
UT WOS:000664191800001
PM 33991997
DA 2023-06-08
ER

PT J
AU Cheung, KS
   Chung, KL
   Leung, WK
AF Cheung, Ka Shing
   Chung, Kit Lam
   Leung, Wai K.
TI Chemopreventive Effect of Metformin on Gastric Cancer Development
SO GUT AND LIVER
LA English
DT Review
DE Helicobacter pylori; Chemoprevention; Diabetes mellitus; Metformin; Gut
   microbiota
ID HELICOBACTER-PYLORI ERADICATION; PUMP INHIBITOR USE; DIABETES-MELLITUS;
   INTESTINAL METAPLASIA; REFLUX ESOPHAGITIS; ATROPHIC GASTRITIS; INDUCED
   APOPTOSIS; SERUM GASTRIN; GROWTH-FACTOR; RISK
AB Although Helicobacter pylori infection is the most important causative factor for gastric cancer (GC), H. pylori eradication alone does not completely eliminate the GC risk. In addition to H. pylori eradication, other risk factors for GC should be identified and targeted. Diabetes mellitus (DM) confers a 20% increased risk of GC, which could be mediated via several biological mechanisms including the stimulation of cell proliferation via hyperinsulinemia and increased insulingrowth factor production, the promotion of angiogenesis, and DNA damage. With a current global prevalence of 9.3% and a predicted rise to 10.2% by 2030, DM could contribute substantially to the burden of GC cases worldwide. Emerging evidence showed that metformin possesses chemopreventive effects via both direct (e.g., adenosine monophosphate-activated protein kinase activation and subsequent inhibition of the mammalian target of rapamycin pathway) and indirect (e.g., modulation of the interaction between tumor cells and their microenvironment and gut microbiota) pathways. A recent meta-analysis of observational studies showed that metformin use was associated with 24% lower GC risk. However, many available observational studies related to metformin effects suffered from biases including the failure to adjust for the H. pylori infection status and serial glycemic control and time-related biases. Future prospective studies addressing these pitfalls are needed. (Gut Liver, Published online June 25, 2021)
C1 [Cheung, Ka Shing; Leung, Wai K.] Univ Hong Kong, Queen Mary Hosp, Dept Med, Hong Kong, Peoples R China.
   [Cheung, Ka Shing] Univ Hong Kong, Dept Med, Shenzhen Hosp, Shenzhen, Peoples R China.
   [Chung, Kit Lam] Univ Hong Kong, Li Ka Shing Fac Med, Hong Kong, Peoples R China.
C3 University of Hong Kong; University of Hong Kong; University of Hong
   Kong
RP Leung, WK (通讯作者)，Univ Hong Kong, Queen Mary Hosp, Dept Med, Hong Kong, Peoples R China.
EM waikleung@hku.hk
RI ; Leung, Wai Keung/B-8140-2011
OI Chung, Kit Lam/0000-0003-1264-6602; Leung, Wai Keung/0000-0002-5993-1059
CR Arana A, 2011, EPIDEMIOLOGY, V22, P876, DOI [10.1097/EDE.0b013e31823198fc, 10.1097/EDE.0b013e3182093a0f]
   Bianchini F, 2002, LANCET ONCOL, V3, P565, DOI 10.1016/S1470-2045(02)00849-5
   Bosetti C, 2020, ANN ONCOL, V31, P558, DOI 10.1016/j.annonc.2020.02.012
   Bray Freddie, 2018, CA Cancer J Clin, V68, P394, DOI 10.3322/caac.21492
   Cavaleiro-Pinto M, 2011, CANCER CAUSE CONTROL, V22, P375, DOI 10.1007/s10552-010-9707-2
   Cerda-Opazo Paulina, 2018, Oncotarget, V9, P12853, DOI 10.18632/oncotarget.24402
   Cervantes A, 2013, CANCER TREAT REV, V39, P60, DOI 10.1016/j.ctrv.2012.09.007
   Chen GX, 2019, ONCOL REP, V41, P405, DOI 10.3892/or.2018.6783
   Chen HN, 2016, GASTRIC CANCER, V19, P166, DOI 10.1007/s10120-015-0462-7
   Chen YL, 2013, GASTRIC CANCER, V16, P389, DOI 10.1007/s10120-012-0197-7
   Cheung KS, 2020, CANCER EPIDEM BIOMAR, V29, P493, DOI 10.1158/1055-9965.EPI-19-1044
   Cheung KS, 2019, DIABETES CARE, V42, P1769, DOI 10.2337/dc19-0437
   Cheung KS, 2019, JNCI-J NATL CANCER I, V111, P1109, DOI 10.1093/jnci/djz067
   Cheung KS, 2019, THER ADV GASTROENTER, V12, DOI 10.1177/1756284819834511
   Cheung Ka Shing, 2018, Oncotarget, V9, P36891, DOI 10.18632/oncotarget.26382
   Cheung KS, 2019, JNCI-J NATL CANCER I, V111, P484, DOI 10.1093/jnci/djy144
   Cheung KS, 2018, JNCI-J NATL CANCER I, V110, P743, DOI 10.1093/jnci/djx267
   Cheung KS, 2018, GUT, V67, P28, DOI 10.1136/gutjnl-2017-314605
   Cheung KS, 2019, WORLD J GASTROENTERO, V25, P2990, DOI 10.3748/wjg.v25.i24.2990
   Cheung KS, 2018, WORLD J GASTRO ONCOL, V10, P115, DOI 10.4251/wjgo.v10.i5.115
   Chia NY, 2015, GUT, V64, P707, DOI 10.1136/gutjnl-2013-306596
   Chiurillo M.A., 2015, WORLD J EXP MED, V5, P84, DOI [10.5493/wjem.v5.i2.84, DOI 10.5493/WJEM.V5.I2.84]
   Correa Pelayo, 2004, Gastric Cancer, V7, P9, DOI 10.1007/s10120-003-0265-0
   Courtois S, 2019, GASTRIC CANCER, V22, P653, DOI 10.1007/s10120-019-00952-w
   Courtois S, 2018, FUTURE MICROBIOL, V13, P1575, DOI 10.2217/fmb-2018-0184
   Courtois S, 2017, EUR J CANCER, V84, P193, DOI 10.1016/j.ejca.2017.07.020
   Cuzick J, 2009, LANCET ONCOL, V10, P501, DOI 10.1016/S1470-2045(09)70035-X
   Dandona P, 1996, LANCET, V347, P444, DOI 10.1016/S0140-6736(96)90013-6
   Dimitroulakos J, 2002, NEOPLASIA, V4, P337, DOI 10.1038/sj.neo.7900247
   Eikawa S, 2015, P NATL ACAD SCI USA, V112, P1809, DOI 10.1073/pnas.1417636112
   Fock KM, 2014, ALIMENT PHARM THER, V40, P250, DOI 10.1111/apt.12814
   Ford AC, 2020, GUT, V69, P2113, DOI 10.1136/gutjnl-2020-320839
   Franciosi M, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0071583
   Ge ZM, 2011, EUR J GASTROEN HEPAT, V23, P1127, DOI 10.1097/MEG.0b013e32834b8d73
   Hamada H, 2000, ALIMENT PHARM THER, V14, P729
   Han G, 2015, CANCER BIOL THER, V16, P77, DOI 10.4161/15384047.2014.987021
   Heckman-Stoddard BM, 2017, DIABETOLOGIA, V60, P1639, DOI 10.1007/s00125-017-4372-6
   Home PD, 2010, DIABETOLOGIA, V53, P1838, DOI 10.1007/s00125-010-1804-y
   Hooi JKY, 2017, GASTROENTEROLOGY, V153, P420, DOI 10.1053/j.gastro.2017.04.022
   Hsieh MC, 2012, EXP DIABETES RES, DOI 10.1155/2012/413782
   Huang DQ, 2016, ONCOTARGET, V7, P6188, DOI 10.18632/oncotarget.6748
   Hwang YJ, 2018, ALIMENT PHARM THER, V47, P380, DOI 10.1111/apt.14424
   Ikeda F, 2009, GASTROENTEROLOGY, V136, P1234, DOI 10.1053/j.gastro.2008.12.045
   International Agency for Research on Cancer, 2014, IARC WORK GROUP REP, V8
   Jalving M, 2010, EUR J CANCER, V46, P2369, DOI 10.1016/j.ejca.2010.06.012
   Jiang KL, 2019, J GASTROEN HEPATOL, V34, P1898, DOI 10.1111/jgh.14759
   Jun KH, 2015, ONCOL REP, V34, P2047, DOI 10.3892/or.2015.4191
   Kato K, 2012, MOL CANCER THER, V11, P549, DOI 10.1158/1535-7163.MCT-11-0594
   KEYOMARSI K, 1991, CANCER RES, V51, P3602
   Kim TJ, 2016, J GASTROEN HEPATOL, V31, P1705, DOI 10.1111/jgh.13329
   Kim YI, 2014, ALIMENT PHARM THER, V39, P854, DOI 10.1111/apt.12660
   Kuipers EJ, 1996, NEW ENGL J MED, V334, P1018, DOI 10.1056/NEJM199604183341603
   Kusama T, 2002, GASTROENTEROLOGY, V122, P308, DOI 10.1053/gast.2002.31093
   Lee JK, 2020, AM J GASTROENTEROL, V115, P706, DOI 10.14309/ajg.0000000000000591
   Lee MS, 2011, BMC CANCER, V11, DOI 10.1186/1471-2407-11-20
   Leung WK, 2006, CLIN CANCER RES, V12, P4766, DOI 10.1158/1078-0432.CCR-06-0693
   Li BF, 2021, CANCER-AM CANCER SOC, V127, P1805, DOI 10.1002/cncr.33412
   Li PW, 2018, ONCOL LETT, V15, P1191, DOI 10.3892/ol.2017.7370
   Li WQ, 2014, JNCI-J NATL CANCER I, V106, DOI 10.1093/jnci/dju116
   LORENZI M, 1986, J CLIN INVEST, V77, P322, DOI 10.1172/JCI112295
   Lundell L, 2015, ALIMENT PHARM THER, V42, P649, DOI 10.1111/apt.13324
   Miao ZF, 2017, ONCOTARGET, V8, P44881, DOI 10.18632/oncotarget.16487
   Moayyedi P, 2019, GASTROENTEROLOGY, V157, P682, DOI 10.1053/j.gastro.2019.05.056
   Park HJ, 2002, CIRC RES, V91, P143, DOI 10.1161/01.RES.0000028149.15986.4C
   Patrignani P, 2016, J AM COLL CARDIOL, V68, P967, DOI 10.1016/j.jacc.2016.05.083
   Pimanov SI, 2008, J GASTROEN HEPATOL, V23, P1666, DOI 10.1111/j.1440-1746.2007.04983.x
   Pollak M, 2008, NAT REV CANCER, V8, P915, DOI 10.1038/nrc2536
   Rokkas T, 2007, HELICOBACTER, V12, P32, DOI 10.1111/j.1523-5378.2007.00563.x
   Ruiter R, 2012, DIABETES CARE, V35, P119, DOI 10.2337/dc11-0857
   Saeedi P., 2019, DIABETES RES CLIN PR, V157, DOI DOI 10.1016/J.DIABRES.2019.107843
   Shaheen NJ, 2002, CANCER-AM CANCER SOC, V94, P950, DOI 10.1002/cncr.10333.abs
   Shimoyama S, 2013, WORLD J GASTROENTERO, V19, P6902, DOI 10.3748/wjg.v19.i40.6902
   Shuai Y, 2020, CLIN TRANSL ONCOL, V22, P1580, DOI 10.1007/s12094-020-02304-y
   Singh PP, 2013, ANN ONCOL, V24, P1721, DOI 10.1093/annonc/mdt150
   Sona MF, 2018, JPN J CLIN ONCOL, V48, P426, DOI 10.1093/jjco/hyy047
   Song H, 2015, BMJ-BRIT MED J, V351, DOI 10.1136/bmj.h3867
   Song X, 2021, HELICOBACTER, V26, DOI 10.1111/hel.12781
   Song Z, 2017, MOL MED REP, V15, P1909, DOI 10.3892/mmr.2017.6205
   Suissa S, 2012, DIABETES CARE, V35, P2665, DOI 10.2337/dc12-0788
   Sung JJY, 2000, AM J PATHOL, V157, P729, DOI 10.1016/S0002-9440(10)64586-5
   Tanigawa N, 1997, J CLIN ONCOL, V15, P826, DOI 10.1200/JCO.1997.15.2.826
   Targownik LE, 2015, AM J GASTROENTEROL, V110, P1647, DOI 10.1038/ajg.2015.210
   Tian T, 2012, EXP CLIN ENDOCR DIAB, V120, P217, DOI 10.1055/s-0031-1297969
   Tseng CH, 2016, AGING-US, V8, P1636, DOI 10.18632/aging.101019
   Upala S, 2017, EUR J GASTROEN HEPAT, V29, P153, DOI 10.1097/MEG.0000000000000774
   Upala S, 2016, J DIGEST DIS, V17, P433, DOI 10.1111/1751-2980.12367
   Valaee S, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0174486
   Valent F, 2015, J DIABETES COMPLICAT, V29, P1056, DOI 10.1016/j.jdiacomp.2015.07.017
   Van Cutsem E, 2016, LANCET, V388, P2654, DOI 10.1016/S0140-6736(16)30354-3
   Wang YB, 2021, PHARMACOL RES, V165, DOI 10.1016/j.phrs.2021.105425
   Watari J, 2008, CLIN GASTROENTEROL H, V6, P409, DOI 10.1016/j.cgh.2007.12.044
   Wijnhoven BPL, 1999, BRIT J SURG, V86, P529, DOI 10.1046/j.1365-2168.1999.01082.x
   Wong BCY, 2004, JAMA-J AM MED ASSOC, V291, P187, DOI 10.1001/jama.291.2.187
   Wong BCY, 2012, GUT, V61, P812, DOI 10.1136/gutjnl-2011-300154
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Yamagata H, 2005, DIABETES CARE, V28, P789, DOI 10.2337/diacare.28.4.789
   Yamamoto Y, 1999, J BIOL CHEM, V274, P27307, DOI 10.1074/jbc.274.38.27307
   Yang P, 2009, EUR J CANCER, V45, P2867, DOI 10.1016/j.ejca.2009.04.019
   Yoon JM, 2013, WORLD J GASTROENTERO, V19, P936, DOI 10.3748/wjg.v19.i6.936
   Yusufu A, 2020, ONCOL LETT, V20, DOI 10.3892/ol.2020.12160
   Zhou XL, 2017, ONCOTARGET, V8, P55622, DOI 10.18632/oncotarget.16973
   1994, IARC MONOGR EVAL CAR, V61, P177
NR 102
TC 2
Z9 2
U1 3
U2 6
PU EDITORIAL OFFICE GUT & LIVER
PI SEOUL
PA 305 LOTTE GOLD ROSE II, 890-59, DAECHI 4-DONG, GANGNAM-GU, SEOUL,
   135-839, SOUTH KOREA
SN 1976-2283
EI 2005-1212
J9 GUT LIVER
JI Gut Liver
PD MAR
PY 2022
VL 16
IS 2
BP 147
EP 156
DI 10.5009/gnl210132
EA JUN 2021
PG 10
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 5C1MD
UT WOS:000701901600001
PM 34158423
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Zhang, Y
   Cheng, Y
   Liu, J
   Zuo, JH
   Yan, LP
   Thring, RW
   Ba, XQ
   Qi, DK
   Wu, MJ
   Gao, YT
   Tong, HB
AF Zhang, Ya
   Cheng, Yang
   Liu, Jian
   Zuo, Jihui
   Yan, Liping
   Thring, Ronald W.
   Ba, Xueqing
   Qi, Dake
   Wu, Mingjiang
   Gao, Yitian
   Tong, Haibin
TI Tauroursodeoxycholic acid functions as a critical effector mediating
   insulin sensitization of metformin in obese mice
SO REDOX BIOLOGY
LA English
DT Article
DE Metformin; Insulin resistance; Tauroursodeoxycholic acid; Nrf2; Bile
   salt hydrolase
ID INDUCED APOPTOSIS; RESISTANCE; MECHANISMS; CELLS; LIVER; NRF2
AB Metformin is widely used to surmount insulin resistance (IR) and type 2 diabetes. Accumulating evidence sug-gests that metformin may improve IR through regulating gut microbiota and bile acids. However, the underlying mechanisms remain unclear. Our metabolomic analysis showed that metformin significantly increased the accumulation of tauroursodeoxycholic acid (TUDCA) in intestine and liver from high-fat diet (HFD)-induced IR mice. TUDCA also alleviated IR, and reduced oxidative stress and intestinal inflammation in ob/ob mice. TUDCA blocked KEAP1 to bind with Nrf2, resulting in Nrf2 translocation into nuclear and initiating the transcription of antioxidant genes, which eventually reduced intracellular ROS accumulation and improved insulin signaling. Analysis of gut microbiota further revealed that metformin reduced the relative abundance of Bifidobacterium, which produces bile salt hydrolase (BSH). The reduction in BSH was probably crucial for the accumulation of TUDCA. Metformin also increased the proportion of Akkermanisia muciniphlia in gut microbiota of ob/ob mice via TUDCA. These beneficial effects of metformin in remodeling gut microbiota, reducing oxidative stress and improving insulin sensitivity were partly due to the accumulation of TUDCA, suggesting that TUDCA may be a potential therapy for metabolic syndrome.
C1 [Zhang, Ya; Cheng, Yang; Liu, Jian; Zuo, Jihui; Yan, Liping; Thring, Ronald W.; Wu, Mingjiang; Gao, Yitian; Tong, Haibin] Wenzhou Univ, Coll Life & Environm Sci, Zhejiang Prov Key Lab Water Environm & Marine Biol, Wenzhou, Peoples R China.
   [Zhang, Ya] Wenzhou Med Univ, Sch Lab Med & Life Sci, Key Lab Med Genet, Wenzhou, Peoples R China.
   [Ba, Xueqing] Northeast Normal Univ, Minist Educ, Key Lab Mol Epigenet, Changchun, Jilin, Peoples R China.
   [Qi, Dake] Univ Manitoba, Coll Pharm, Winnipeg, MB, Canada.
C3 Wenzhou University; Wenzhou Medical University; Northeast Normal
   University - China; University of Manitoba
RP Gao, YT; Tong, HB (通讯作者)，Wenzhou Univ, Coll Life & Environm Sci, Zhejiang Prov Key Lab Water Environm & Marine Biol, Wenzhou, Peoples R China.
EM gyt@wzu.edu.cn; tonghaibin@gmail.com
FU National Natural Science Foundation of China; Science and Technology
   Program of Wenzhou;  [81872952];  [41876197];  [ZY2019013]
FX Acknowledgements We gratefully thank Qiaojuan Li and Lingfeng Hou
   (Wenzhou Uni-versity) for their assistance in animal experiments. We
   gratefully thank Alan K Chang (Wenzhou University) for helpful
   discussion and for revising the language of the manuscript. We
   gratefully thank Jingling Shen (Wenzhou University) and Weitao Cong
   (Wenzhou Medical Uni-versity) for helpful discussion for revising the
   manuscript.
CR Agius L, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21093240
   Apostolova N, 2020, REDOX BIOL, V34, DOI 10.1016/j.redox.2020.101517
   Backhed F, 2007, P NATL ACAD SCI USA, V104, P979, DOI 10.1073/pnas.0605374104
   Bailey CJ, 2008, DIABETOLOGIA, V51, P1552, DOI 10.1007/s00125-008-1053-5
   Bravard A, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-95117-0
   Castro RE, 2004, J PHARMACOL EXP THER, V311, P845, DOI 10.1124/jpet.104.070532
   da Silva JA, 2021, LIFE SCI, V285, DOI 10.1016/j.lfs.2021.120020
   Dao MC, 2016, GUT, V65, P426, DOI 10.1136/gutjnl-2014-308778
   Fan Y, 2021, NAT REV MICROBIOL, V19, P55, DOI 10.1038/s41579-020-0433-9
   Foretz M, 2014, CELL METAB, V20, P953, DOI 10.1016/j.cmet.2014.09.018
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Hasan WNW, 2014, BMC COMPLEM ALTERN M, V14, DOI 10.1186/1472-6882-14-72
   Jia W, 2018, NAT REV GASTRO HEPAT, V15, P111, DOI 10.1038/nrgastro.2017.119
   Kars M, 2010, DIABETES, V59, P1899, DOI 10.2337/db10-0308
   Ke HR, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.726707
   Kitahara M, 2000, INT J SYST EVOL MICR, V50, P971, DOI 10.1099/00207713-50-3-971
   Legry V, 2017, J CLIN ENDOCR METAB, V102, P3783, DOI 10.1210/jc.2017-01397
   Macchione IG, 2019, EUR REV MED PHARMACO, V23, P8075, DOI 10.26355/eurrev_201909_19024
   McGlone ER, 2019, ANN CLIN BIOCHEM, V56, P326, DOI 10.1177/0004563218817798
   Moreira S, 2017, EXP NEUROL, V295, P77, DOI 10.1016/j.expneurol.2017.05.009
   Mukherjee A, 2020, GUT MICROBES, V12, DOI 10.1080/19490976.2020.1802866
   Muoio DM, 2008, NAT REV MOL CELL BIO, V9, P193, DOI 10.1038/nrm2327
   Nicholson JK, 2012, SCIENCE, V336, P1262, DOI 10.1126/science.1223813
   Pedersen HK, 2016, NATURE, V535, P376, DOI 10.1038/nature18646
   Peng DF, 2019, CANCER LETT, V458, P46, DOI 10.1016/j.canlet.2019.05.031
   Plovier H, 2017, NAT MED, V23, P107, DOI 10.1038/nm.4236
   Sanchez-Rangel E, 2017, DIABETOLOGIA, V60, P1586, DOI 10.1007/s00125-017-4336-x
   Sansome DJ, 2020, DIABETES OBES METAB, V22, P141, DOI 10.1111/dom.13869
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Sola S, 2003, MOL MED, V9, P226, DOI 10.2119/2003-00042.Rodrigues
   Sun CC, 2020, FRONT PHARMACOL, V11, DOI 10.3389/fphar.2020.575390
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Tangvarasittichai S, 2015, WORLD J DIABETES, V6, P456, DOI 10.4239/wjd.v6.i3.456
   Tao YM, 2022, FRONT ENDOCRINOL, V13, DOI 10.3389/fendo.2022.856331
   Therdtatha P, 2021, MICROORGANISMS, V9, DOI 10.3390/microorganisms9050897
   Urpilainen Elina, 2019, Tumour Biol, V41, p1010428318815413, DOI 10.1177/1010428318815413
   Uruno A, 2013, MOL CELL BIOL, V33, P2996, DOI 10.1128/MCB.00225-13
   Vallianou NG, 2019, HORM-INT J ENDOCRINO, V18, P141, DOI 10.1007/s42000-019-00093-w
   Wang WJ, 2018, BRIT J PHARMACOL, V175, P469, DOI 10.1111/bph.14095
   Wu B, 2019, LIFE SCI, V226, P185, DOI 10.1016/j.lfs.2019.04.009
   Yao LN, 2018, ELIFE, V7, DOI 10.7554/eLife.37182
   Yaribeygi H, 2019, J CELL PHYSIOL, V234, P8152, DOI 10.1002/jcp.27603
   Yerra VG, 2013, REDOX BIOL, V1, P394, DOI 10.1016/j.redox.2013.07.005
   Zhang WP, 2017, FREE RADICAL BIO MED, V112, P24, DOI 10.1016/j.freeradbiomed.2017.07.003
   Zhou GC, 2001, J CLIN INVEST, V108, P1167, DOI 10.1172/JCI200113505
   Zhu Q, 2013, EXP CLIN ENDOCR DIAB, V121, P43, DOI 10.1055/s-0032-1321787
   Zou B, 2020, CLIN CHIM ACTA, V509, P167, DOI 10.1016/j.cca.2020.06.006
NR 47
TC 2
Z9 2
U1 11
U2 23
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2213-2317
J9 REDOX BIOL
JI Redox Biol.
PD NOV
PY 2022
VL 57
AR 102481
DI 10.1016/j.redox.2022.102481
PG 14
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 5A0KW
UT WOS:000862586600002
PM 36148770
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Sansome, DJ
   Xie, C
   Veedfald, S
   Horowitz, M
   Rayner, CK
   Wu, TZ
AF Sansome, Daniel J.
   Xie, Cong
   Veedfald, Simon
   Horowitz, Michael
   Rayner, Christopher K.
   Wu, Tongzhi
TI Mechanism of glucose-lowering by metformin in type 2 diabetes: Role of
   bile acids
SO DIABETES OBESITY & METABOLISM
LA English
DT Review
DE bile acids; gastrointestinal function; glucagon-like peptide-1;
   metformin; postprandial glycaemia; type 2 diabetes
ID GLUCAGON-LIKE PEPTIDE-1; FARNESOID-X-RECEPTOR; GUT MICROBIOTA;
   TAUROCHOLIC ACID; OBESE-PATIENTS; BLOOD-GLUCOSE; WEIGHT-LOSS; INSULIN;
   SECRETION; GLP-1
AB Type 2 diabetes mellitus (T2DM) is an increasingly prevalent chronic condition, characterized by abnormally elevated blood glucose concentrations and, as a consequence, increased risk of micro- and macrovascular complications. Metformin is usually the first-line glucose-lowering medication in T2DM; however, despite being used for more than 60 years, the mechanism underlying the glucose-lowering action of metformin remains incompletely understood. Although metformin reduces hepatic glucose production, there is persuasive evidence that the gastrointestinal tract is crucial in mediating this effect, particularly via secretion of the incretin hormone glucagon-like peptide 1 (GLP-1). It is now well recognized that bile acids, in addition to their established function in fat digestion and absorption, are important regulators of glucose metabolism. Exposure of the small and large intestine to bile acids induces GLP-1 secretion, modulates the composition of the gut microbiota, and reduces postprandial blood glucose excursions in humans with and without T2DM. Metformin reduces intestinal bile acid resorption substantially, such that intraluminal bile acids may, at least in part, account for its glucose-lowering effect. The present review focuses on the conceptual shift in our understanding as to how metformin lowers blood glucose in T2DM, with a particular emphasis on the role of intestinal bile acids.
C1 [Sansome, Daniel J.; Xie, Cong; Veedfald, Simon; Horowitz, Michael; Rayner, Christopher K.; Wu, Tongzhi] Univ Adelaide, Adelaide Med Sch, Adelaide, SA, Australia.
   [Sansome, Daniel J.; Xie, Cong; Veedfald, Simon; Horowitz, Michael; Rayner, Christopher K.; Wu, Tongzhi] Univ Adelaide, Ctr Res Excellence Translating Nutr Sci Good Hlth, Adelaide, SA, Australia.
   [Veedfald, Simon] Univ Copenhagen, Dept Biomed Sci, Copenhagen, Denmark.
   [Wu, Tongzhi] Southeast Univ, Sch Med, Zhongda Hosp, Dept Endocrinol,Inst Diabet, Nanjing, Jiangsu, Peoples R China.
C3 University of Adelaide; University of Adelaide; University of
   Copenhagen; Southeast University - China
RP Wu, TZ (通讯作者)，Level 6,AHMS Bldg,North Terrace, Adelaide, SA 5000, Australia.
EM tongzhi.wu@adelaide.edu.au
RI horowitz, michael/HJY-3337-2023; Horowitz, Michael/AAY-3397-2021; Wu,
   Tongzhi/AAB-7343-2021
OI Horowitz, Michael/0000-0002-0942-0306; Wu, Tongzhi/0000-0003-1656-9210;
   Rayner, Christopher/0000-0002-5527-256X
FU Australian National Health and Medical Research Council (NHMRC)
   [APP1147333] Funding Source: Medline; Diabetes Australia Research Trust
   [Y19G-WUTO] Funding Source: Medline
CR Adrian TE, 2012, DIABETOLOGIA, V55, P2343, DOI 10.1007/s00125-012-2593-2
   ADRIAN TE, 1993, GUT, V34, P1219, DOI 10.1136/gut.34.9.1219
   Albaugh VL, 2019, GASTROENTEROLOGY, V156, P1041, DOI 10.1053/j.gastro.2018.11.017
   Bahne E, 2018, JCI INSIGHT, V3, DOI 10.1172/jci.insight.93936
   Borg MJ, 2019, DIABETES OBES METAB, V21, P640, DOI 10.1111/dom.13567
   Bray GA, 2012, DIABETES CARE, V35, P731, DOI 10.2337/dc11-1299
   Bronden A, 2018, DIABETES OBES METAB, V20, P362, DOI 10.1111/dom.13080
   Bronden A, 2017, J CLIN ENDOCR METAB, V102, P4153, DOI 10.1210/jc.2017-01091
   Bryrup T, 2019, DIABETOLOGIA, V62, P1024, DOI 10.1007/s00125-019-4848-7
   Buse JB, 2016, DIABETES CARE, V39, P198, DOI 10.2337/dc15-0488
   Carter D, 2003, DIABETES OBES METAB, V5, P120, DOI 10.1046/j.1463-1326.2003.00252.x
   CASPARY WF, 1977, DIABETOLOGIA, V13, P187, DOI 10.1007/BF01219698
   Cefalu WT, 2019, DIABETES CARE, V42, pS90, DOI 10.2337/dc19-S009
   CREUTZFELDT W, 1979, DIABETOLOGIA, V16, P75, DOI 10.1007/BF01225454
   DEACON CF, 1995, J CLIN ENDOCR METAB, V80, P952, DOI 10.1210/jc.80.3.952
   DeCensi A, 2010, CANCER PREV RES, V3, P1451, DOI 10.1158/1940-6207.CAPR-10-0157
   DeFronzo RA, 2016, DIABETOLOGIA, V59, P1645, DOI 10.1007/s00125-016-3992-6
   Deloose E, 2017, AM J CLIN NUTR, V105, P580, DOI 10.3945/ajcn.116.138297
   Dotson CD, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003974
   Duca FA, 2015, NAT MED, V21, P506, DOI 10.1038/nm.3787
   EISSELE R, 1992, EUR J CLIN INVEST, V22, P283, DOI 10.1111/j.1365-2362.1992.tb01464.x
   Flynn CR, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms8715
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Gontier E, 2008, EUR J NUCL MED MOL I, V35, P95, DOI 10.1007/s00259-007-0563-6
   Griffin SJ, 2017, DIABETOLOGIA, V60, P1620, DOI 10.1007/s00125-017-4337-9
   Hansen M, 2016, DIABETES OBES METAB, V18, P571, DOI 10.1111/dom.12648
   Hansen M, 2017, J DIABETES COMPLICAT, V31, P918, DOI 10.1016/j.jdiacomp.2017.01.011
   HERRMANN C, 1995, DIGESTION, V56, P117, DOI 10.1159/000201231
   Hinke SA, 2002, BIOCHEM BIOPH RES CO, V291, P1302, DOI 10.1006/bbrc.2002.6607
   Inzucchi SE, 2014, JAMA-J AM MED ASSOC, V312, P2668, DOI 10.1001/jama.2014.15298
   Kawamata Y, 2003, J BIOL CHEM, V278, P9435, DOI 10.1074/jbc.M209706200
   Kim KS, 2014, DIABETOLOGIA, V57, P2117, DOI 10.1007/s00125-014-3326-5
   Kim MH, 2014, J ENDOCRINOL, V220, P117, DOI 10.1530/JOE-13-0381
   Kok BP, 2018, MOL METAB, V16, P76, DOI 10.1016/j.molmet.2018.07.013
   Kuhre RE, 2018, MOL METAB, V11, P84, DOI 10.1016/j.molmet.2018.03.007
   Larraufie P, 2019, CELL REP, V26, P1399, DOI 10.1016/j.celrep.2019.01.047
   Lee A, 1998, OBES RES, V6, P47, DOI 10.1002/j.1550-8528.1998.tb00314.x
   Li F, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms3384
   Lindsay JR, 2005, DIABETIC MED, V22, P654, DOI 10.1111/j.1464-5491.2005.01461.x
   Ma K, 2006, J CLIN INVEST, V116, P1102, DOI 10.1172/JCI25604
   Madsen LR, 2019, DIABETOLOGIA, V62, P611, DOI 10.1007/s00125-019-4816-2
   Makishima M, 1999, SCIENCE, V284, P1362, DOI 10.1126/science.284.5418.1362
   Mannucci E, 2004, DIABETES NUTR METAB, V17, P336
   Migoya EM, 2010, CLIN PHARMACOL THER, V88, P801, DOI 10.1038/clpt.2010.184
   Mulherin AJ, 2011, ENDOCRINOLOGY, V152, P4610, DOI 10.1210/en.2011-1485
   Napolitano A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100778
   NATHAN DM, 1993, NEW ENGL J MED, V328, P1676, DOI 10.1056/NEJM199306103282306
   NAUCK MA, 1993, J CLIN INVEST, V91, P301, DOI 10.1172/JCI116186
   NAUCK MA, 1986, J CLIN ENDOCR METAB, V63, P492, DOI 10.1210/jcem-63-2-492
   Oh J, 2016, DIABETES OBES METAB, V18, P104, DOI 10.1111/dom.12577
   Pathak P, 2018, HEPATOLOGY, V68, P1574, DOI 10.1002/hep.29857
   Preiss D, 2017, DIABETES OBES METAB, V19, P356, DOI 10.1111/dom.12826
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Rohde U, 2016, J CLIN ENDOCR METAB, V101, P2076, DOI 10.1210/jc.2016-1133
   Rozengurt N, 2006, AM J PHYSIOL-GASTR L, V291, pG792, DOI 10.1152/ajpgi.00074.2006
   Sayin SI, 2013, CELL METAB, V17, P225, DOI 10.1016/j.cmet.2013.01.003
   Scarpello JHB, 1998, DIABETIC MED, V15, P651, DOI 10.1002/(SICI)1096-9136(199808)15:8<651::AID-DIA628>3.0.CO;2-A
   Seghieri M, 2013, DIABETOLOGIA, V56, P156, DOI 10.1007/s00125-012-2738-3
   Sekirov I, 2010, PHYSIOL REV, V90, P859, DOI 10.1152/physrev.00045.2009
   Solis-Herrera C, 2013, DIABETES CARE, V36, P2756, DOI 10.2337/dc12-2072
   Stepensky D, 2002, DRUG METAB DISPOS, V30, P861, DOI 10.1124/dmd.30.8.861
   STUMVOLL M, 1995, NEW ENGL J MED, V333, P550, DOI 10.1056/NEJM199508313330903
   SUM CF, 1992, DIABETIC MED, V9, P61, DOI 10.1111/j.1464-5491.1992.tb01716.x
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Thomas C, 2009, CELL METAB, V10, P167, DOI 10.1016/j.cmet.2009.08.001
   Thondam SK, 2012, DIABETIC MED, V29, pE205, DOI 10.1111/j.1464-5491.2012.03675.x
   Trabelsi MS, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms8629
   Turner RC, 1998, LANCET, V352, P837, DOI 10.1016/s0140-6736(98)07019-6
   Watson LE, 2019, J CLIN ENDOCR METAB, V104, P3311, DOI 10.1210/jc.2018-02736
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Wu T, 2017, DIABETOLOGIA, V60, pS92
   Wu T, 2013, DIABETES OBES METAB, V15, P474, DOI 10.1111/dom.12043
   Wu TZ, 2017, EXPERT REV GASTROENT, V11, P157, DOI 10.1080/17474124.2017.1273769
   Wu TZ, 2016, HANDB EXP PHARMACOL, V233, P137, DOI 10.1007/164_2015_9
   Wu TZ, 2014, DIABETES RES CLIN PR, V106, pE3, DOI 10.1016/j.diabres.2014.08.004
   Wu TZ, 2013, J CLIN ENDOCR METAB, V98, pE718, DOI 10.1210/jc.2012-3961
   Zhang X, 2019, DIABETES CARE, V42, P520, DOI 10.2337/dc18-2156
   Zhou KX, 2009, DIABETES, V58, P1434, DOI 10.2337/db08-0896
NR 78
TC 38
Z9 42
U1 2
U2 34
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1462-8902
EI 1463-1326
J9 DIABETES OBES METAB
JI Diabetes Obes. Metab.
PD FEB
PY 2020
VL 22
IS 2
BP 141
EP 148
DI 10.1111/dom.13869
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA KA3YF
UT WOS:000505733500001
PM 31468642
DA 2023-06-08
ER

PT J
AU Robeson, MS
   Manna, K
   Randolph, C
   Byrum, S
   Hakkak, R
AF Robeson, Michael S., II
   Manna, Kanishka
   Randolph, Christopher
   Byrum, Stephanie
   Hakkak, Reza
TI Short-Term Metformin Treatment Enriches Bacteroides dorei in an Obese
   Liver Steatosis Zucker Rat Model
SO FRONTIERS IN MICROBIOLOGY
LA English
DT Article
DE obesity; metformin; Bacteroides dorei; Zucker rat; gut microbiota
ID HUMAN GUT MICROBIOME; UNITED-STATES; INSULIN-RESISTANCE;
   DIABETES-MELLITUS; DOUBLE-BLIND; ADOLESCENTS; DISEASE; CHILDREN;
   PREVALENCE; VULGATUS
AB Obesity is the leading cause of health-related diseases in the United States and World. Previously, we reported that obesity can change gut microbiota using the Zucker rat model. Metformin is an oral anti-hyperglycemic agent approved by the FDA to treat type 2 diabetes (T2D) in adults and children older than 10 years of age. The correlation of short-term metformin treatment and specific alterations to the gut microbiota in obese models is less known. Short-term metformin has been shown to reduce liver steatosis. Here we investigate the effects of short-term metformin treatment on population of gut microbiota profile in an obese rat model. Five week old obese (n = 12) female Zucker rats after 1 week of acclimation, received AIN-93 G diet for 8 weeks and then rats were randomly assigned into two groups (6 rats/group): (1) obese without metformin (ObC), or (2) obese with metformin (ObMet). Metformin was mixed with AIN-93G diet at 1,000 mg/kg of diet. Rats were weighed twice per week. All rats were sacrificed at the end of metformin treatment at 10 weeks and fecal samples were collected and kept at -80 degrees C. Total microbial DNA was collected directly from the fecal samples used for shotgun-metagenomics sequencing and subsequently analyzed using MetaPlAn and HUMAnN. After stringent data filtering and quality control we found significant differences (p = 0.0007) in beta diversity (Aitchison distances) between the ObC vs. ObMet groups. Supervised and unsupervised analysis of the log-ratios Bacteroides dorei and B. massiliensis vs. all other Bacteroides spp., revealed that B. dorei and B. massiliensis were enriched in the ObMet group, while the remaining Bacteroides spp. where enriched in the ObC group (p = 0.002). The contributional diversity of pathways is also significantly associated by treatment group (p = 0.008). In summary, in the obese Zucker rat model, short-term metformin treatment changes the gut microbiota profile, particularly altering the composition Bacteroides spp. between ObC and ObMet.
C1 [Robeson, Michael S., II] Univ Arkansas Med Sci, Dept Biomed Informat, Little Rock, AR 72205 USA.
   [Manna, Kanishka; Byrum, Stephanie] Univ Arkansas Med Sci, Dept Biochem & Mol Biol, Little Rock, AR 72205 USA.
   [Randolph, Christopher; Hakkak, Reza] Arkansas Childrens Res Inst, Little Rock, AR 72202 USA.
   [Hakkak, Reza] Univ Arkansas Med Sci, Dept Dietet & Nutr, Little Rock, AR 72205 USA.
   [Hakkak, Reza] Univ Arkansas Med Sci, Dept Pediat, Little Rock, AR 72205 USA.
C3 University of Arkansas System; University of Arkansas Medical Sciences;
   University of Arkansas System; University of Arkansas Medical Sciences;
   University of Arkansas System; University of Arkansas Medical Sciences;
   University of Arkansas System; University of Arkansas Medical Sciences
RP Hakkak, R (通讯作者)，Arkansas Childrens Res Inst, Little Rock, AR 72202 USA.; Hakkak, R (通讯作者)，Univ Arkansas Med Sci, Dept Dietet & Nutr, Little Rock, AR 72205 USA.; Hakkak, R (通讯作者)，Univ Arkansas Med Sci, Dept Pediat, Little Rock, AR 72205 USA.
EM Hakkakreza@uams.edu
RI Robeson, Michael Scott/J-5211-2019
OI Robeson, Michael Scott/0000-0001-7119-6301; Manna,
   Kanishka/0000-0003-3927-5004
FU Arkansas Children's Research Institute; Arkansas Biosciences Institute
FX This research was supported, in part, by the Arkansas Children's
   Research Institute and the Arkansas Biosciences Institute to RH.
CR Angulo P, 2007, ALIMENT PHARM THER, V25, P883, DOI 10.1111/j.1365-2036.2007.03246.x
   Atabek ME, 2008, J PEDIATR ENDOCR MET, V21, P339
   Baker JL, 2021, GENOME RES, V31, P64, DOI 10.1101/gr.265645.120
   Bakir MA, 2006, INT J SYST EVOL MICR, V56, P1639, DOI 10.1099/ijs.0.64257-0
   Beghini F, 2021, ELIFE, V10, DOI 10.7554/eLife.65088
   Benson DA, 2005, NUCLEIC ACIDS RES, V33, pD34, DOI 10.1093/nar/gki063
   Bloom SM, 2011, CELL HOST MICROBE, V9, P390, DOI 10.1016/j.chom.2011.04.009
   BRAY GA, 1989, VITAM HORM, V45, P1
   Brufani C, 2013, HORM RES PAEDIAT, V80, P78, DOI 10.1159/000353760
   Burgert TS, 2008, PEDIATR DIABETES, V9, P567, DOI 10.1111/j.1399-5448.2008.00434.x
   Cao TTB, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.573891
   Corsetti JP, 2000, ATHEROSCLEROSIS, V148, P231, DOI 10.1016/S0021-9150(99)00265-8
   Cuiv PO, 2017, ANAEROBE, V47, P209, DOI 10.1016/j.anaerobe.2017.06.002
   Davis-Richardson AG, 2014, FRONT MICROBIOL, V5, DOI 10.3389/fmicb.2014.00678
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Devaraj S, 2013, CLIN CHEM, V59, P617, DOI 10.1373/clinchem.2012.187617
   Drew GC, 2021, NAT REV MICROBIOL, V19, P623, DOI 10.1038/s41579-021-00550-7
   Fabbrini E, 2010, HEPATOLOGY, V51, P679, DOI 10.1002/hep.23280
   Fedarko MW, 2020, NAR GENOM BIOINFORM, V2, DOI 10.1093/nargab/lqaa023
   Field D, 2008, NAT BIOTECHNOL, V26, P541, DOI 10.1038/nbt1360
   Field D, 2007, COMP FUNCT GENOM, P1, DOI 10.1155/2007/47304
   Flegal KM, 2016, JAMA-J AM MED ASSOC, V315, P2284, DOI 10.1001/jama.2016.6458
   Food and Drug Administration, 2005, GUID IND EST MAX SAF, P7
   Foretz M, 2014, CELL METAB, V20, P953, DOI 10.1016/j.cmet.2014.09.018
   Fryar C.D., 2021, NCHS HLTH E STATS
   Fujita Y, 2017, CURR DIABETES REP, V17, DOI 10.1007/s11892-017-0829-8
   Fukunishi S, 2014, J CLIN BIOCHEM NUTR, V54, P39, DOI 10.3164/jcbn.13-49
   GAWLER DJ, 1989, J ENDOCRINOL, V122, P207, DOI 10.1677/joe.0.1220207
   Gustavsson C, 2011, J MOL ENDOCRINOL, V47, P129, DOI 10.1530/JME-11-0007
   Gutierrez N, 2019, MSYSTEMS, V4, DOI 10.1128/mSystems.00185-19
   Hakkak R, 2021, BIOMED REP, V14, DOI 10.3892/br.2021.1425
   Hakkak R, 2018, BIOMEDICINES, V6, DOI 10.3390/biomedicines6020055
   Hakkak R, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0181451
   Hakkak R, 2015, J MED FOOD, V18, P1274, DOI 10.1089/jmf.2015.0002
   Hakkak R, 2012, GENES NUTR, V7, P549, DOI 10.1007/s12263-012-0294-6
   Harsch Igor Alexander, 2018, Med Sci (Basel), V6, DOI 10.3390/medsci6020032
   Hobby GP, 2019, AM J PHYSIOL-RENAL, V316, pF1211, DOI 10.1152/ajprenal.00298.2018
   Hong SH, 2009, ISME J, V3, P1365, DOI 10.1038/ismej.2009.89
   Jovel J, 2016, FRONT MICROBIOL, V7, DOI 10.3389/fmicb.2016.00459
   Kay JP, 2001, METABOLISM, V50, P1457, DOI 10.1053/meta.2001.28078
   Kazemian N, 2020, MICROBIOME, V8, DOI 10.1186/s40168-020-00821-0
   Krueger F., 2015, TRIM GALORE WRAPPER
   Lagkouvardos I, 2016, NAT MICROBIOL, V1, DOI [10.1038/nmicrobiol.2016.131, 10.1038/NMICROBIOL.2016.131]
   Lazo M, 2013, AM J EPIDEMIOL, V178, P38, DOI 10.1093/aje/kws448
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Lee SM, 2013, NATURE, V501, P426, DOI 10.1038/nature12447
   Lentferink YE, 2018, DRUGS, V78, P1887, DOI 10.1007/s40265-018-1025-0
   Ley RE, 2005, P NATL ACAD SCI USA, V102, P11070, DOI 10.1073/pnas.0504978102
   Ley RE, 2006, NATURE, V444, P1022, DOI 10.1038/4441022a
   Lin HZ, 2000, NAT MED, V6, P998, DOI 10.1038/79697
   Love-Osborne K, 2008, J PEDIATR, V152, P817, DOI 10.1016/j.jpeds.2008.01.018
   Lv ZQ, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.00191
   Madsen A, 2015, SCI REP-UK, V5, DOI 10.1038/srep16430
   Martin M., 2011, EMBNET J, V17, P10, DOI DOI 10.14806/EJ.17.1.200
   Martino C, 2019, MSYSTEMS, V4, DOI 10.1128/mSystems.00016-19
   Maruthur NM, 2016, ANN INTERN MED, V164, P740, DOI 10.7326/M15-2650
   McCreight LJ, 2016, DIABETOLOGIA, V59, P426, DOI 10.1007/s00125-015-3844-9
   McDonagh MS, 2014, JAMA PEDIATR, V168, P178, DOI 10.1001/jamapediatrics.2013.4200
   Mills RH, 2022, NAT MICROBIOL, V7, P262, DOI 10.1038/s41564-021-01050-3
   Morton JT, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-10656-5
   Ogden CL, 2008, JAMA-J AM MED ASSOC, V299, P2401, DOI 10.1001/jama.299.20.2401
   Ogden CL, 2014, JAMA-J AM MED ASSOC, V311, P806, DOI 10.1001/jama.2014.732
   Pascale A, 2019, CURR OPIN PHARMACOL, V49, P1, DOI 10.1016/j.coph.2019.03.011
   Pastor-Villaescusa B, 2016, TRIALS, V17, DOI 10.1186/s13063-016-1403-4
   Pedersen RM, 2013, ANAEROBE, V24, P1, DOI 10.1016/j.anaerobe.2013.08.004
   Raman V, 2021, PEDIATRICS, V147, DOI 10.1542/peds.2020-044982
   RIEPE SP, 1980, J CLIN INVEST, V66, P314, DOI 10.1172/JCI109859
   Rodriguez J, 2018, CURR OPIN CLIN NUTR, V21, P294, DOI 10.1097/MCO.0000000000000468
   Rotmistrovsky K., 2017, BMTAGGER BEST MATCH
   Ryan FJ, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-15342-5
   Sanz Y, 2015, PEDIATR RES, V77, P236, DOI 10.1038/pr.2014.170
   Schippa S, 2010, BMC MICROBIOL, V10, DOI 10.1186/1471-2180-10-175
   Segata N, 2011, GENOME BIOL, V12, DOI 10.1186/gb-2011-12-6-r60
   Sengupta P, 2013, INT J PREVENTIVE MED, V4, P624
   Sepich-Poore GD, 2021, SCIENCE, V371, P1331, DOI 10.1126/science.abc4552
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Sonnenburg ED, 2010, CELL, V141, P1241, DOI 10.1016/j.cell.2010.05.005
   Srinivasan S, 2006, J CLIN ENDOCR METAB, V91, P2074, DOI 10.1210/jc.2006-0241
   Stirling C, 2010, BMC HEALTH SERV RES, V10, DOI 10.1186/1472-6963-10-122
   Sui Y, 2019, DIABETOL METAB SYNDR, V11, DOI 10.1186/s13098-019-0491-1
   Tagliabue A, 2013, NUTR METAB CARDIOVAS, V23, P160, DOI 10.1016/j.numecd.2012.09.002
   Thomas I, 2017, PEDIATR DIABETES, V18, P10, DOI 10.1111/pedi.12473
   Tremaroli V, 2012, NATURE, V489, P242, DOI 10.1038/nature11552
   Turnbaugh PJ, 2008, CELL HOST MICROBE, V3, P213, DOI 10.1016/j.chom.2008.02.015
   Turnbaugh PJ, 2009, SCI TRANSL MED, V1, DOI 10.1126/scitranslmed.3000322
   Uritskiy GV, 2018, MICROBIOME, V6, DOI 10.1186/s40168-018-0541-1
   Usyk M, 2021, GENOME MED, V13, DOI 10.1186/s13073-021-00974-z
   Vazquez-Baeza Y, 2018, ANNU REV PHARMACOL, V58, P253, DOI 10.1146/annurev-pharmtox-042017-031849
   Vazquez-Baeza Y, 2013, GIGASCIENCE, V2, DOI 10.1186/2047-217X-2-16
   Waidmann M, 2003, GASTROENTEROLOGY, V125, P162, DOI 10.1016/S0016-5085(03)00672-3
   Wang BH, 2017, ENGINEERING, V3, P71, DOI 10.1016/J.ENG.2017.01.008
   Wang NH, 2016, DIABETES RES CLIN PR, V122, P170, DOI 10.1016/j.diabres.2016.10.006
   Wasimuddin, 2020, MOL ECOL RESOUR, V20, P1558, DOI 10.1111/1755-0998.13215
   Weersma RK, 2020, GUT, V69, P1510, DOI 10.1136/gutjnl-2019-320204
   Welsh JA, 2013, J PEDIATR-US, V162, P496, DOI 10.1016/j.jpeds.2012.08.043
   Wexler AG, 2017, NAT MICROBIOL, V2, DOI 10.1038/nmicrobiol.2017.26
   Whang A, 2019, EBIOMEDICINE, V39, P591, DOI 10.1016/j.ebiom.2018.11.046
   Wilson DM, 2010, ARCH PEDIAT ADOL MED, V164, P116, DOI 10.1001/archpediatrics.2009.264
   Wu XX, 2021, ANN MED, V53, P1797, DOI 10.1080/07853890.2021.1990392
   Yoshida N, 2018, CIRCULATION, V138, P2486, DOI 10.1161/CIRCULATIONAHA.118.033714
   Zhang FY, 2021, CANCERS, V13, DOI 10.3390/cancers13112514
   Zhang MC, 2019, BMJ OPEN DIAB RES CA, V7, DOI 10.1136/bmjdrc-2019-000717
   Zhang Q, 2020, DIABET METAB SYND OB, V13, P5003, DOI 10.2147/DMSO.S286430
   Zhang X, 2015, SCI REP-UK, V5, DOI 10.1038/srep14405
   Zhang YF, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-18414-8
   Zimmermann M, 2019, NATURE, V570, P462, DOI 10.1038/s41586-019-1291-3
   ZUCKER LM, 1972, J LIPID RES, V13, P234
NR 107
TC 1
Z9 1
U1 2
U2 8
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1664-302X
J9 FRONT MICROBIOL
JI Front. Microbiol.
PD MAR 30
PY 2022
VL 13
AR 834776
DI 10.3389/fmicb.2022.834776
PG 13
WC Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology
GA 0V3DB
UT WOS:000788224000001
PM 35432282
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Borg, MJ
   Rayner, CK
   Jones, KL
   Horowitz, M
   Xie, C
   Wu, TZ
AF Borg, Malcolm J.
   Rayner, Christopher K.
   Jones, Karen L.
   Horowitz, Michael
   Xie, Cong
   Wu, Tongzhi
TI Gastrointestinal Mechanisms Underlying the Cardiovascular Effect of
   Metformin
SO PHARMACEUTICALS
LA English
DT Review
DE metformin; cardiovascular; gastrointestinal; mechanisms; bile acids; gut
   microbiota; glucagon-like-peptide-1; gastric emptying; postprandial
   hypotension; type 2 diabetes
ID GLUCAGON-LIKE PEPTIDE-1; TYPE-2 DIABETES-MELLITUS; MESENTERIC
   BLOOD-FLOW; FARNESOID-X RECEPTOR; POSTPRANDIAL HYPOTENSION; HEART-RATE;
   MYOCARDIAL-INFARCTION; GLYCEMIC RESPONSES; GLUCOSE-TOLERANCE; ORAL
   GLUCOSE
AB Metformin, the most widely prescribed drug therapy for type 2 diabetes, has pleiotropic benefits, in addition to its capacity to lower elevated blood glucose levels, including mitigation of cardiovascular risk. The mechanisms underlying the latter remain unclear. Mechanistic studies have, hitherto, focused on the direct effects of metformin on the heart and vasculature. It is now appreciated that effects in the gastrointestinal tract are important to glucose-lowering by metformin. Gastrointestinal actions of metformin also have major implications for cardiovascular function. This review summarizes the gastrointestinal mechanisms underlying the action of metformin and their potential relevance to cardiovascular benefits.
C1 [Borg, Malcolm J.; Rayner, Christopher K.; Jones, Karen L.; Horowitz, Michael; Xie, Cong; Wu, Tongzhi] Univ Adelaide, Adelaide Med Sch, Adelaide, SA 5000, Australia.
   [Borg, Malcolm J.; Rayner, Christopher K.; Jones, Karen L.; Horowitz, Michael; Xie, Cong; Wu, Tongzhi] Univ Adelaide, Ctr Res Excellence Translating Nutr Sci Good Hlth, Adelaide, SA 5000, Australia.
   [Borg, Malcolm J.; Jones, Karen L.; Horowitz, Michael; Wu, Tongzhi] Royal Adelaide Hosp, Endocrine & Metab Unit, Adelaide, SA 5000, Australia.
   [Wu, Tongzhi] Southeast Univ, Inst Diabet, Sch Med, Nanjing 210096, Peoples R China.
C3 University of Adelaide; University of Adelaide; Royal Adelaide Hospital;
   Southeast University - China
RP Wu, TZ (通讯作者)，Univ Adelaide, Adelaide Med Sch, Adelaide, SA 5000, Australia.; Wu, TZ (通讯作者)，Univ Adelaide, Ctr Res Excellence Translating Nutr Sci Good Hlth, Adelaide, SA 5000, Australia.; Wu, TZ (通讯作者)，Royal Adelaide Hosp, Endocrine & Metab Unit, Adelaide, SA 5000, Australia.; Wu, TZ (通讯作者)，Southeast Univ, Inst Diabet, Sch Med, Nanjing 210096, Peoples R China.
EM malcolm.borg@sa.gov.au; chris.rayner@adelaide.edu.au;
   karen.jones@adelaide.edu.au; michael.horowitz@adelaide.edu.au;
   c.xie@adelaide.edu.au; tongzhi.wu@adelaide.edu.au
RI horowitz, michael/HJY-3337-2023; Wu, Tongzhi/AAB-7343-2021; Horowitz,
   Michael/AAY-3397-2021
OI Horowitz, Michael/0000-0002-0942-0306; Jones, Karen/0000-0002-1155-5816;
   Rayner, Christopher/0000-0002-5527-256X; Wu,
   Tongzhi/0000-0003-1656-9210; Xie, Cong/0000-0002-0054-9269
FU Australia National Health and Medical Research Council (NHMRC); Diabetes
   Australia; Royal Adelaide Hospital Research Committee; China Scholarship
   Council; University of Adelaide William T Southcott Research Fellowship;
   Mid-Career Fellowship from The Hospital Research Foundation
FX The authors' work in this area is supported by the Australia National
   Health and Medical Research Council (NHMRC), Diabetes Australia and
   Royal Adelaide Hospital Research Committee. C.X. is supported by a
   postgraduate scholarship from the China Scholarship Council. K.L.J. is
   supported by a University of Adelaide William T Southcott Research
   Fellowship. T.W. is supported by a Mid-Career Fellowship from The
   Hospital Research Foundation.
CR Abdul-Ghani M, 2017, DIABETES CARE, V40, P813, DOI 10.2337/dc16-2736
   Aronow WS, 1997, J AM GERIATR SOC, V45, P1051, DOI 10.1111/j.1532-5415.1997.tb05965.x
   Bahne E, 2018, JCI INSIGHT, V3, DOI 10.1172/jci.insight.93936
   Bahne E, 2016, DIABETES OBES METAB, V18, P955, DOI 10.1111/dom.12697
   Bailey CJ, 2017, DIABETOLOGIA, V60, P1566, DOI 10.1007/s00125-017-4318-z
   BARNES S, 1975, J CLIN PATHOL, V28, P506, DOI 10.1136/jcp.28.6.506
   BARRAGAN JM, 1994, AM J PHYSIOL, V266, pE459, DOI 10.1152/ajpendo.1994.266.3.E459
   Bethel MA, 2018, LANCET DIABETES ENDO, V6, P105, DOI 10.1016/S2213-8587(17)30412-6
   Bishop-Bailey D, 2004, P NATL ACAD SCI USA, V101, P3668, DOI 10.1073/pnas.0400046101
   Bonora E, 2002, INT J CLIN PRACT, P5
   Borg MJ, 2019, DIABETES OBES METAB, V21, P1251, DOI 10.1111/dom.13632
   Borg MJ, 2019, DIABETES OBES METAB, V21, P640, DOI 10.1111/dom.13567
   Buse JB, 2016, DIABETES CARE, V39, P198, DOI 10.2337/dc15-0488
   Carter D, 2003, DIABETES OBES METAB, V5, P120, DOI 10.1046/j.1463-1326.2003.00252.x
   CASPARY WF, 1971, DIABETOLOGIA, V7, P379, DOI 10.1007/BF01219474
   Charytan DM, 2019, DIABETES OBES METAB, V21, P1199, DOI 10.1111/dom.13642
   Chiasson JL, 2002, LANCET, V359, P2072, DOI 10.1016/S0140-6736(02)08905-5
   Coleman RL, 2019, CARDIOVASC DIABETOL, V18, DOI 10.1186/s12933-019-0933-y
   Crowley MJ, 2017, DIABETES CARE, V40, P1787, DOI 10.2337/dc17-1528
   CUBER JC, 1994, DIABETES METAB, V20, P532
   Dalsgaard NB, 2019, DIABETES, V68, DOI 10.2337/db19-1145-P
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   DeFronzo RA, 2016, DIABETOLOGIA, V59, P1645, DOI 10.1007/s00125-016-3992-6
   Desai MS, 2017, HEPATOLOGY, V65, P189, DOI 10.1002/hep.28890
   Duca FA, 2015, NAT MED, V21, P506, DOI 10.1038/nm.3787
   Fisman EZ, 1999, CARDIOLOGY, V91, P195, DOI 10.1159/000006909
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Gao JS, 2017, MOL MED REP, V16, P673, DOI 10.3892/mmr.2017.6643
   Gentilcore D, 2005, AM J MED, V118, DOI 10.1016/j.amjmed.2005.05.019
   Gentilcore D, 2007, HYPERTENSION, V50, pE159, DOI 10.1161/HYPERTENSIONAHA.107.097717
   Griffin SJ, 2017, DIABETOLOGIA, V60, P1620, DOI 10.1007/s00125-017-4337-9
   Gundewar S, 2009, CIRC RES, V104, P403, DOI 10.1161/CIRCRESAHA.108.190918
   Guo GL, 2018, NAT MED, V24, P1789, DOI 10.1038/s41591-018-0273-6
   Hanefeld M, 2004, EUR HEART J, V25, P10, DOI 10.1016/S0195-668X(03)00468-8
   Hanefeld M, 2007, CARDIOVASC DIABETOL, V6, DOI 10.1186/1475-2840-6-20
   Hanefeld Markolf, 2006, Endocr Pract, V12 Suppl 1, P56
   Heine RJ, 2004, DIABETIC MED, V21, P208, DOI 10.1111/j.1464-5491.2004.01149.x
   Heseltine D, 1991, Clin Auton Res, V1, P219, DOI 10.1007/BF01824990
   Holman RR, 2008, NEW ENGL J MED, V359, P1577, DOI 10.1056/NEJMoa0806470
   Holman RR, 2018, J DIABETES, V10, P683, DOI 10.1111/1753-0407.12770
   Holman RR, 2017, LANCET DIABETES ENDO, V5, P877, DOI 10.1016/S2213-8587(17)30309-1
   Ikeda T, 2000, BIOCHEM PHARMACOL, V59, P887, DOI 10.1016/S0006-2952(99)00396-2
   Jie ZY, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-00900-1
   Jones KL, 2020, DIABETES OBES METAB, V22, P788, DOI 10.1111/dom.13956
   Kaiser T, 2004, DIABETOLOGIA, V47, P575, DOI 10.1007/s00125-003-1318-y
   Khurana S, 2011, CTS-CLIN TRANSL SCI, V4, P210, DOI 10.1111/j.1752-8062.2011.00272.x
   Kong MF, 1999, DIABETES CARE, V22, P503, DOI 10.2337/diacare.22.3.503
   Madden KM, 2015, J AM GERIATR SOC, V63, P1484, DOI 10.1111/jgs.13503
   Maida A, 2011, DIABETOLOGIA, V54, P339, DOI 10.1007/s00125-010-1937-z
   Marathe CS, 2015, J CLIN ENDOCR METAB, V100, P3565, DOI 10.1210/JC.2015-2482
   Moller S, 2010, J HEPATOL, V53, P179, DOI 10.1016/j.jhep.2010.02.023
   Nagell CF, 2004, SCAND J GASTROENTERO, V39, P353, DOI 10.1080/00365520410004424
   Nesti L, 2017, NUTR METAB CARDIOVAS, V27, P657, DOI 10.1016/j.numecd.2017.04.009
   Nguyen A, 2008, CELL SIGNAL, V20, P2180, DOI 10.1016/j.cellsig.2008.06.014
   Noyan-Ashraf MH, 2009, DIABETES, V58, P975, DOI 10.2337/db08-1193
   Nystrom T, 2004, AM J PHYSIOL-ENDOC M, V287, pE1209, DOI 10.1152/ajpendo.00237.2004
   Park HM, 2019, J NEUROGASTROENTEROL, V25, P387, DOI 10.5056/jnm19037
   PARK SY, 2018, DIABETES S1, V67, DOI DOI 10.2337/db18-467-P
   Patti ME, 2009, OBESITY, V17, P1671, DOI 10.1038/oby.2009.102
   Peuler JD, 1999, CARDIOVASC RES, V43, P237, DOI 10.1016/S0008-6363(99)00051-6
   Phillips LK, 2014, J DIABETES COMPLICAT, V28, P894, DOI 10.1016/j.jdiacomp.2014.06.005
   Poornima I, 2008, CIRC-HEART FAIL, V1, P153, DOI 10.1161/CIRCHEARTFAILURE.108.766402
   Pryor R, 2015, BIOCHEM J, V471, P307, DOI 10.1042/BJ20150497
   RIFKIND BM, 1984, JAMA-J AM MED ASSOC, V251, P365
   Rohde U, 2016, J CLIN ENDOCR METAB, V101, P2076, DOI 10.1210/jc.2016-1133
   Ross S, 2015, CIRC-CARDIOVASC GENE, V8, P618, DOI 10.1161/CIRCGENETICS.114.000952
   Roumie CL, 2012, ANN INTERN MED, V157, P601, DOI 10.7326/0003-4819-157-9-201211060-00003
   Russo A, 2003, DIGEST DIS SCI, V48, P1221, DOI 10.1023/A:1024182403984
   Sakar Y, 2010, J PHYSIOL PHARMACOL, V61, P301
   Samah S, 2016, DIABETES RES CLIN PR, V118, P172, DOI 10.1016/j.diabres.2016.06.014
   Sansome DJ, 2020, DIABETES OBES METAB, V22, P141, DOI 10.1111/dom.13869
   Sato D, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18061282
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Solymar M, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0207947
   STUMVOLL M, 1995, NEW ENGL J MED, V333, P550, DOI 10.1056/NEJM199508313330903
   SUM CF, 1992, DIABETIC MED, V9, P61, DOI 10.1111/j.1464-5491.1992.tb01716.x
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Tang WHW, 2017, CIRC RES, V120, P1183, DOI 10.1161/CIRCRESAHA.117.309715
   Thazhath SS, 2017, DIABETES VASC DIS RE, V14, P59, DOI 10.1177/1479164116666761
   Tian Jingyan, 2017, Liver Res, V1, P208, DOI 10.1016/j.livres.2017.12.007
   Trabelsi MS, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms8629
   Trahair LG, 2015, DIABETOLOGIA, V58, P1769, DOI 10.1007/s00125-015-3638-0
   Trahair LG, 2015, J AM MED DIR ASSOC, V16, P521, DOI 10.1016/j.jamda.2015.01.097
   Trahair LG, 2014, J CLIN ENDOCR METAB, V99, pE2628, DOI 10.1210/jc.2014-2475
   Trahair LG, 2014, J AM MED DIR ASSOC, V15, P394, DOI 10.1016/j.jamda.2014.01.011
   Tseng CH, 2019, J AM HEART ASSOC, V8, DOI 10.1161/JAHA.118.011640
   Turner RC, 1998, LANCET, V352, P854, DOI 10.1016/s0140-6736(98)07037-8
   Ussher JR, 2014, CIRC RES, V114, P1788, DOI 10.1161/CIRCRESAHA.114.301958
   Ussher JR, 2012, ENDOCR REV, V33, P187, DOI 10.1210/er.2011-1052
   Vanis L, 2011, AM J PHYSIOL-REG I, V300, P1524, DOI 10.1152/ajpregu.00378.2010
   Wang WT, 2019, FRONT PHYSIOL, V10, DOI 10.3389/fphys.2019.00374
   Wascher TC, 2005, EUR J CLIN INVEST, V35, P551, DOI 10.1111/j.1365-2362.2005.01550.x
   WILCOCK C, 1991, J PHARM PHARMACOL, V43, P120, DOI 10.1111/j.2042-7158.1991.tb06645.x
   WILCOCK C, 1994, XENOBIOTICA, V24, P49, DOI 10.3109/00498259409043220
   Witte AB, 2009, REGUL PEPTIDES, V158, P57, DOI 10.1016/j.regpep.2009.07.013
   Wu Ting, 2015, Modular Machine Tool & Automatic Manufacturing Technique, P137, DOI 10.13462/j.cnki.mmtamt.2015.06.037
   Wu TZ, 2017, EXPERT REV GASTROENT, V11, P157, DOI 10.1080/17474124.2017.1273769
   Wu TZ, 2017, DIABETES OBES METAB, V19, P290, DOI 10.1111/dom.12812
   Wu TZ, 2016, BIOMARK MED, V10, P1167, DOI 10.2217/bmm-2016-0164
   Wu TZ, 2014, DIABETES RES CLIN PR, V106, pE3, DOI 10.1016/j.diabres.2014.08.004
   Wulffele MG, 2004, J INTERN MED, V256, P1, DOI 10.1111/j.1365-2796.2004.01328.x
   Xie C, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00576
   Xu T, 2015, DIABETES CARE, V38, P1858, DOI 10.2337/dc15-0658
   Yamazaki K, 2004, EUR J PHARMACOL, V488, P213, DOI 10.1016/j.ejphar.2004.02.019
   Zhang X, 2020, J CLIN ENDOCR METAB, V105, pE2877, DOI 10.1210/clinem/dgaa341
NR 105
TC 2
Z9 2
U1 0
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1424-8247
J9 PHARMACEUTICALS-BASE
JI Pharmaceuticals
PD NOV
PY 2020
VL 13
IS 11
AR 410
DI 10.3390/ph13110410
PG 14
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA OX9WZ
UT WOS:000593907700001
PM 33266396
OA gold, Green Accepted, Green Published
DA 2023-06-08
ER

PT J
AU Adeshirlarijaney, A
   Zou, J
   Tran, HQ
   Chassaing, B
   Gewirtz, AT
AF Adeshirlarijaney, Aneseh
   Zou, Jun
   Tran, Hao Q.
   Chassaing, Benoit
   Gewirtz, Andrew T.
TI Amelioration of metabolic syndrome by metformin associates with reduced
   indices of low-grade inflammation independently of the gut microbiota
SO AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
LA English
DT Review
DE antibiotics; germ free; high-fat diet; metabolic syndrome; metformin;
   microbiota; steatosis
ID DIET-INDUCED OBESITY; ACTIVATED PROTEIN-KINASE; INTESTINAL MICROBIOTA;
   INSULIN-RESISTANCE; ALTERS; IMPACT
AB Metformin beneficially impacts several aspects of metabolic syndrome including dysglycemia, obesity, and liver dysfunction, thus making it a widely used frontline treatment for early-stage type 2 diabetes, which is associated with these disorders. Several mechanisms of action for metformin have been proposed, including that it acts as an anti-inflammatory agent, possibly as a result of its impact on intestinal microbiota. In accord with this possibility, we observed herein that, in mice with diet-induced metabolic syndrome, metformin impacts the gut microbiota by preventing its encroachment upon the host, a feature of metabolic syndrome in mice and humans. However, the ability of metformin to beneficially impact metabolic syndrome in mice was not markedly altered by reduction or elimination of gut microbiota, achieved by the use of antibiotics or germfree mice. Although reducing or eliminating microbiota by itself suppressed diet-induced dysglycemia, other features of metabolic syndrome including obesity, hepatic steatosis, and low-grade inflammation remained suppressed by metformin in the presence or absence of gut microbiota. These results support a role for anti-inflammatory activity of metformin, irrespective of gut microbiota, in driving some of the beneficial impacts of this drug on metabolic syndrome.
C1 [Adeshirlarijaney, Aneseh; Zou, Jun; Tran, Hao Q.; Chassaing, Benoit; Gewirtz, Andrew T.] Georgia State Univ, Inst Biomed Sci, Atlanta, GA 30303 USA.
   [Chassaing, Benoit] Georgia State Univ, Inst Neurosci, Atlanta, GA 30303 USA.
C3 University System of Georgia; Georgia State University; University
   System of Georgia; Georgia State University
RP Gewirtz, AT (通讯作者)，Georgia State Univ, Inst Biomed Sci, Atlanta, GA 30303 USA.
EM agewirtz@gsu.edu
RI ZOU, JUN/AAD-3904-2019; Chassaing, Benoit/R-3819-2017
OI Chassaing, Benoit/0000-0002-4285-769X
FU National Institute of Diabetes and Digestive and Kidney Diseases
   [DK-099071, DK-083890]; Career Development Award from the Crohn's and
   Colitis Foundation of America
FX This work was supported by National Institute of Diabetes and Digestive
   and Kidney Diseases Grants DK-099071 (to A. T. Gewirtz) and DK-083890
   (to A. T. Gewirtz). B. Chassaing is supported by a Career Development
   Award from the Crohn's and Colitis Foundation of America.
CR An HY, 2016, J ENDOCRINOL, V228, pR97, DOI 10.1530/JOE-15-0447
   Backhed F, 2007, P NATL ACAD SCI USA, V104, P979, DOI 10.1073/pnas.0605374104
   BAILEY CJ, 1986, ARCH INT PHARMACOD T, V282, P233
   Bauer PV, 2018, CELL METAB, V27, P101, DOI 10.1016/j.cmet.2017.09.019
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Carvalho FA, 2012, ANNU REV PHYSIOL, V74, P177, DOI 10.1146/annurev-physiol-020911-153330
   Chassaing B, 2017, CELL MOL GASTROENTER, V4, P205, DOI 10.1016/j.jcmgh.2017.04.001
   Chassaing B, 2016, NATURE, V536, DOI 10.1038/nature18000
   Chassaing B, 2014, GASTROENTEROLOGY, V147, P1363, DOI 10.1053/j.gastro.2014.08.033
   Chatterjee S, 2017, LANCET, V389, P2239, DOI 10.1016/S0140-6736(17)30058-2
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Duan QL, 2017, BRIT J PHARMACOL, V174, P2140, DOI 10.1111/bph.13833
   Forslund K, 2017, NATURE, V545, P116, DOI 10.1038/nature22318
   Fryer LGD, 2002, J BIOL CHEM, V277, P25226, DOI 10.1074/jbc.M202489200
   Guo GL, 2018, NAT MED, V24, P1789, DOI 10.1038/s41591-018-0273-6
   Hansen AK, 2014, WORLD J GASTROENTERO, V20, P17727, DOI 10.3748/wjg.v20.i47.17727
   Lee H, 2018, GUT MICROBES, V9, P155, DOI 10.1080/19490976.2017.1405209
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Patterson E, 2015, MICROBIOL-SGM, V161, P182, DOI 10.1099/mic.0.082610-0
   Rodriguez J, 2018, CURR OPIN CLIN NUTR, V21, P294, DOI 10.1097/MCO.0000000000000468
   Schuiveling M, 2018, CURR DRUG TARGETS, V19, P945, DOI 10.2174/1389450118666170613081730
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Tateya S, 2010, ENDOCRINOLOGY, V151, P971, DOI 10.1210/en.2009-0926
   Thaiss CA, 2018, SCIENCE, V359, P1376, DOI 10.1126/science.aar3318
   Tran HQ, 2020, CELL MOL GASTROENTER, V9, P313, DOI 10.1016/j.jcmgh.2019.09.009
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Zhang XR, 2016, EUR J PHARMACOL, V779, P46, DOI 10.1016/j.ejphar.2016.03.011
   Zhao WJ, 2016, CELL SIGNAL, V28, P1401, DOI 10.1016/j.cellsig.2016.06.018
   Zhong MW, 2016, WORLD J GASTROENTERO, V22, P6706, DOI 10.3748/wjg.v22.i29.6706
   Zhou J, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19102863
   Zou J, 2018, CELL HOST MICROBE, V23, P41, DOI 10.1016/j.chom.2017.11.003
NR 31
TC 29
Z9 29
U1 1
U2 12
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0193-1849
EI 1522-1555
J9 AM J PHYSIOL-ENDOC M
JI Am. J. Physiol.-Endocrinol. Metab.
PD DEC
PY 2019
VL 317
IS 6
BP E1121
EP E1130
DI 10.1152/ajpendo.00245.2019
PG 10
WC Endocrinology & Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Physiology
GA KC7QK
UT WOS:000507367600005
PM 31573841
OA Bronze, Green Published
DA 2023-06-08
ER

PT J
AU Huang, QY
   Yao, F
   Zhou, CAR
   Huang, XY
   Wang, Q
   Long, H
   Wu, QM
AF Huang, Qi-You
   Yao, Fei
   Zhou, Chuan-Ren
   Huang, Xiao-Ying
   Wang, Qiang
   Long, Hui
   Wu, Qing-Ming
TI Role of gut microbiome in regulating the effectiveness of metformin in
   reducing colorectal cancer in type 2 diabetes
SO WORLD JOURNAL OF CLINICAL CASES
LA English
DT Review
DE Metformin; Colorectal cancer; Gut microbiota; Type 2 diabetes mellitus
ID ABERRANT CRYPT FOCI; IMMUNE; PROLIFERATION; AGMATINE; ADENOMA; TUMOR;
   RISK; 5-FLUOROURACIL; MODULATION; RECURRENCE
AB The prevalence of colorectal cancer (CRC) and type 2 diabetes mellitus (T2DM) is increasing globally. It is rarely noticed that the incidence of CRC is higher in patients with T2DM. What needs to be mentioned is that metformin, a commonly used clinical drug for T2DM, attracts scholars' attention because of its benefits in lowering the risk of developing CRC. Hence, we try to find the common grounds of initiation of T2DM and CRC and the reason why metformin reduces the risk of CRC in patients with T2DM. We noticed consistent changes of gut microbiota, such as elevated Bacteroides, Prevotella and Bifidobacterium and depressed Firmicutes and Lactobacillus. Furthermore, many studies in recent years have proved that the efficacy of metformin, such as improving blood glucose, depends on the gut microbiota. Coincidentally, the progression of CRC is inseparable from the contributions of gut microbiota. Therefore, we first proposed the concept of the metformin-gut microbiota-CRC (in T2DM) axis to explain the effect of metformin in reducing CRC in patients with T2DM. In this review, we elaborated the new concept and its potential clinical application value.
C1 [Huang, Qi-You; Yao, Fei; Zhou, Chuan-Ren; Huang, Xiao-Ying; Wang, Qiang; Wu, Qing-Ming] Wuhan Univ Sci & Technol, Med Coll, Inst Infect Immunol & Tumor Microenvironm, 2 Huangjiahu West Rd,Baishazhou Ave, Wuhan 430065, Hubei, Peoples R China.
   [Long, Hui] Wuhan Univ Sci & Technol, Tianyou Affiliated Hosp, Dept Gastroenterol, Wuhan 430064, Hubei, Peoples R China.
C3 Wuhan University of Science & Technology; Wuhan University of Science &
   Technology
RP Wu, QM (通讯作者)，Wuhan Univ Sci & Technol, Med Coll, Inst Infect Immunol & Tumor Microenvironm, 2 Huangjiahu West Rd,Baishazhou Ave, Wuhan 430065, Hubei, Peoples R China.
EM wuhe9224@sina.com
FU National Natural Science Foundation of China [81573239]
FX Supported by National Natural Science Foundation of China, No. 81573239.
CR Allen J, 2019, GENOME MED, V11, DOI 10.1186/s13073-019-0621-2
   Amable G, 2019, INT J BIOCHEM CELL B, V112, P88, DOI 10.1016/j.biocel.2019.05.004
   Bahrambeigi S, 2020, BIOCHEM PHARMACOL, V174, DOI 10.1016/j.bcp.2019.113787
   Bartolini I, 2020, WORLD J GASTROENTERO, V26, DOI 10.3748/wjg.v26.i20.2498
   Bauer PV, 2018, CELL METAB, V27, P101, DOI 10.1016/j.cmet.2017.09.019
   Belcheva A, 2014, CELL, V158, P288, DOI 10.1016/j.cell.2014.04.051
   Bishnu A, 2019, INT J BIOCHEM CELL B, V107, P116, DOI 10.1016/j.biocel.2018.12.016
   Bordini HP, 2017, MOL CARCINOGEN, V56, P913, DOI 10.1002/mc.22545
   Brody H, 2015, NATURE, V521, pS1, DOI 10.1038/521S1a
   Brown JR, 2020, JCI INSIGHT, V5, DOI 10.1172/jci.insight.133247
   Bryrup T, 2019, DIABETOLOGIA, V62, P1024, DOI 10.1007/s00125-019-4848-7
   Bu WJ, 2014, BRIT J CLIN PHARMACO, V78, P301, DOI 10.1111/bcp.12350
   Cirenajwis H, 2010, ANTI-CANCER DRUG, V21, P897, DOI 10.1097/CAD.0b013e32833f2f77
   Cremonesi E, 2018, GUT, V67, P1984, DOI 10.1136/gutjnl-2016-313498
   Cui PF, 2016, INT J PHARMACEUT, V506, P79, DOI 10.1016/j.ijpharm.2016.04.039
   Curry JM, 2018, FRONT ONCOL, V8, DOI 10.3389/fonc.2018.00436
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Dekker E, 2019, LANCET, V394, P1467, DOI 10.1016/S0140-6736(19)32319-0
   Deleemans JM, 2019, BMC CANCER, V19, DOI 10.1186/s12885-019-6473-8
   Demb J, 2019, CLIN TRANSL GASTROEN, V10, DOI 10.14309/ctg.0000000000000092
   Di Martino ML, 2013, INT J MED MICROBIOL, V303, P484, DOI 10.1016/j.ijmm.2013.06.008
   Donohoe DR, 2014, CANCER DISCOV, V4, P1387, DOI 10.1158/2159-8290.CD-14-0501
   Eikawa S, 2015, P NATL ACAD SCI USA, V112, P1809, DOI 10.1073/pnas.1417636112
   Fernandes JM, 2020, DIS COLON RECTUM, V63, P918, DOI 10.1097/DCR.0000000000001626
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Han MS, 2017, INT J COLORECTAL DIS, V32, P1223, DOI 10.1007/s00384-017-2782-z
   Higurashi T, 2016, LANCET ONCOL, V17, P475, DOI 10.1016/S1470-2045(15)00565-3
   Hirayama T, 2019, ANTICANCER RES, V39, P4699, DOI 10.21873/anticanres.13652
   Hosono K, 2010, CANCER PREV RES, V3, P1077, DOI 10.1158/1940-6207.CAPR-10-0186
   Hosono K, 2010, MOL CARCINOGEN, V49, P662, DOI 10.1002/mc.20637
   Huang WS, 2018, J CELL BIOCHEM, V119, P6943, DOI 10.1002/jcb.26898
   Isome M, 2007, AM J PHYSIOL-CELL PH, V293, pC705, DOI 10.1152/ajpcell.00084.2007
   Jacob S, 2018, ENVIRON SCI EUR, V30, DOI 10.1186/s12302-018-0179-4
   Kanadiya MK, 2013, J DIABETES COMPLICAT, V27, P463, DOI 10.1016/j.jdiacomp.2013.04.010
   Kang S, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0205449
   Kim SH, 2017, ONCOTARGET, V8, P56546, DOI 10.18632/oncotarget.17798
   Kumar NP, 2019, BMC INFECT DIS, V19, DOI 10.1186/s12879-019-4648-1
   Lan B, 2017, FRONT BIOSCI-LANDMRK, V22, P248, DOI 10.2741/4484
   Lascar N, 2018, LANCET DIABETES ENDO, V6, P69, DOI 10.1016/S2213-8587(17)30186-9
   Lee H, 2019, IMMUNE NETW, V19, DOI 10.4110/in.2019.19.e28
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Li L, 2019, EBIOMEDICINE, V48, P301, DOI 10.1016/j.ebiom.2019.09.021
   Long XH, 2019, NAT MICROBIOL, V4, P2319, DOI 10.1038/s41564-019-0541-3
   Mei ZB, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0091818
   Miranda VC, 2016, CLIN COLORECTAL CANC, V15, P321, DOI 10.1016/j.clcc.2016.04.011
   Mogavero A, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-16149-z
   Molderings GJ, 2004, CANCER, V101, P858, DOI 10.1002/cncr.20407
   Nakajima H, 2020, LIFE-BASEL, V10, DOI 10.3390/life10090195
   Napolitano A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100778
   Nie ZH, 2016, PHARM BIOL, V54, P2636, DOI 10.1080/13880209.2016.1176057
   Okubo R, 2020, BRAIN BEHAV IMMUN, V85, P186, DOI 10.1016/j.bbi.2019.02.025
   Park JH, 2019, CANCER SCI, V110, P2834, DOI 10.1111/cas.14124
   Patil S, 2020, ARCH ORAL BIOL, V113, DOI 10.1016/j.archoralbio.2020.104710
   Pereira Felipe V, 2018, Oncotarget, V9, P25808, DOI 10.18632/oncotarget.25380
   Peters BA, 2016, MICROBIOME, V4, DOI 10.1186/s40168-016-0218-6
   Pryor R, 2019, CELL, V178, P1299, DOI 10.1016/j.cell.2019.08.003
   Qin YF, 2018, GENOME BIOL, V19, DOI 10.1186/s13059-018-1389-1
   Reimer RA, 2014, J ENDOCRINOL, V220, P361, DOI 10.1530/JOE-13-0484
   Rosario D, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.00775
   Ryan PM, 2020, CAN J DIABETES, V44, P146, DOI 10.1016/j.jcjd.2019.05.008
   Sena P, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19051478
   Sethi V, 2018, GASTROENTEROLOGY, V155, P33, DOI 10.1053/j.gastro.2018.04.001
   Shen P, 2018, MOL ONCOL, V12, P1856, DOI 10.1002/1878-0261.12384
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Soberanes S, 2019, CELL METAB, V29, P335, DOI [10.1016/j.cmet.2018.09.019, 10.1016/j.cmet.2018.12.001]
   Soltani G, 2019, BMC ENDOCR DISORD, V19, DOI 10.1186/s12902-019-0444-6
   Suhaimi NAM, 2017, MOL CANCER THER, V16, P2035, DOI 10.1158/1535-7163.MCT-16-0793
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Nguyen TT, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-38778-2
   Tomimoto A, 2008, CANCER SCI, V99, P2136, DOI 10.1111/j.1349-7006.2008.00933.x
   Tong XL, 2018, MBIO, V9, DOI 10.1128/mBio.02392-17
   Vaez H, 2016, INT IMMUNOPHARMACOL, V40, P501, DOI 10.1016/j.intimp.2016.10.002
   Volarevic V, 2015, ARCH TOXICOL, V89, P437, DOI 10.1007/s00204-014-1263-1
   Wang JF, 2005, ACTA PHARMACOL SIN, V26, P616, DOI 10.1111/j.1745-7254.2005.00084.x
   Wang LJ, 2020, GUT, V69, P1988, DOI 10.1136/gutjnl-2019-320105
   Wang SQ, 2019, CANCER BIOL THER, V20, P338, DOI 10.1080/15384047.2018.1529108
   Wang YD, 2018, EUR J PHARMACOL, V834, P45, DOI 10.1016/j.ejphar.2018.07.006
   Wong SH, 2019, NAT REV GASTRO HEPAT, V16, P690, DOI 10.1038/s41575-019-0209-8
   Wu B, 2019, LIFE SCI, V226, P185, DOI 10.1016/j.lfs.2019.04.009
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Xiao Y, 2020, VIRULENCE, V11, P39, DOI 10.1080/21505594.2019.1706305
   Xue J, 2019, ENDOCR J, V66, P859, DOI 10.1507/endocrj.EJ18-0567
   Yachida S, 2019, NAT MED, V25, P968, DOI 10.1038/s41591-019-0458-7
   Yang Q, 2018, MED SCI MONITOR, V24, P2225, DOI 10.12659/MSM.906687
   Yu SY, 2019, J GASTROEN HEPATOL, V34, P1758, DOI 10.1111/jgh.14735
   Yu T, 2017, CELL, pe16
   Zhang C, 2019, MOL MED REP, V19, P1203, DOI 10.3892/mmr.2018.9765
   Zhang XQ, 2015, SCI REP-UK, V5, DOI 10.1038/srep10737
   Zhang ZJ, 2011, DIABETES CARE, V34, P2323, DOI 10.2337/dc11-0512
   Zhao D, 2005, NEUROPHARMACOLOGY, V48, P597, DOI 10.1016/j.neuropharm.2004.12.004
   Zheng DW, 2019, NAT BIOMED ENG, V3, P717, DOI 10.1038/s41551-019-0423-2
   Zhu WH, 2019, J EXP MED, V216, P2378, DOI 10.1084/jem.20181939
   Zhu ZX, 2020, GUT MICROBES, DOI 10.1080/19490976.2020.1788891
NR 93
TC 6
Z9 9
U1 0
U2 15
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 2307-8960
J9 WORLD J CLIN CASES
JI World J. Clin. Cases
PD DEC 26
PY 2020
VL 8
IS 24
DI 10.12998/wjcc.v8.i24.6213
PG 17
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA PM2PB
UT WOS:000603646900001
PM 33392303
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Palacios, T
   Vitetta, L
   Coulson, S
   Madigan, CD
   Lam, YY
   Manuel, R
   Briskey, D
   Hendy, C
   Kim, JN
   Ishoey, T
   Soto-Giron, MJ
   Schott, EM
   Toledo, G
   Caterson, ID
AF Palacios, Talia
   Vitetta, Luis
   Coulson, Samantha
   Madigan, Claire D.
   Lam, Yan Y.
   Manuel, Rachel
   Briskey, David
   Hendy, Chelsea
   Kim, Ji-Nu
   Ishoey, Thomas
   Soto-Giron, Maria J.
   Schott, Eric M.
   Toledo, Gerardo
   Caterson, Ian D.
TI Targeting the Intestinal Microbiota to Prevent Type 2 Diabetes and
   Enhance the Effect of Metformin on Glycaemia: A Randomised Controlled
   Pilot Study
SO NUTRIENTS
LA English
DT Article
DE prediabetes; type 2 diabetes mellitus; metformin; intestinal microbiota;
   probiotics; short-chain fatty acids
ID GUT MICROBIOTA; INSULIN-RESISTANCE; GLUCOSE-TOLERANCE; WEIGHT-LOSS;
   FERMENTATION; PREVALENCE; OVERWEIGHT; PROBIOTICS; BUTYRATE; MELLITUS
AB Early treatment may prevent or delay the onset of type 2 diabetes mellitus (T2DM) in individuals who are at high risk. Lifestyle interventions and the hypoglycemic drug metformin have been shown to reduce T2DM incidence. The effectiveness of such interventions may be enhanced by targeting environmental factors such as the intestinal microbiota, which has been proven to predict the response to lifestyle interventions and play a part in mediating the glucose-lowering effects of metformin. Shifts in the intestinal microbiota "towards a more balanced state" may promote glucose homeostasis by regulating short-chain fatty acids' production. This study aimed to investigate the safety and effect of a multi-strain probiotic on glycemic, inflammatory, and permeability markers in adults with prediabetes and early T2DM and to assess whether the probiotic can enhance metformin's effect on glycaemia. A randomised controlled pilot study was conducted in 60 adults with a BMI >= 25 kg/m(2)and with prediabetes or T2DM (within the previous 12 months). The participants were randomised to a multi-strain probiotic (L. plantarum,L. bulgaricus,L. gasseri,B. breve,B. animalis sbsp. lactis,B. bifidum,S. thermophilus, andS. boulardii) or placebo for 12 weeks. Analyses of the primary outcome (fasting plasma glucose) and secondary outcomes, including, but not limited to, circulating lipopolysaccharide, zonulin, and short chain fatty acids and a metagenomic analysis of the fecal microbiome were performed at baseline and 12 weeks post-intervention. The results showed no significant differences in the primary and secondary outcome measures between the probiotic and placebo group. An analysis of a subgroup of participants taking metformin showed a decrease in fasting plasma glucose, HbA1c, insulin resistance, and zonulin; an increase in plasma butyrate concentrations; and an enrichment of microbial butyrate-producing pathways in the probiotic group but not in the placebo group. Probiotics may act as an adjunctive to metformin by increasing the production of butyrate, which may consequently enhance glucose management.
C1 [Palacios, Talia; Madigan, Claire D.; Hendy, Chelsea; Caterson, Ian D.] Univ Sydney, Boden Collaborat Obes Nutr Exercise & Eating Diso, Charles Perkins Ctr, Sydney, NSW 2006, Australia.
   [Palacios, Talia; Vitetta, Luis; Coulson, Samantha] Univ Sydney, Fac Med & Hlth, Sydney, NSW 2006, Australia.
   [Vitetta, Luis] Medlab Clin, Sydney, NSW 2015, Australia.
   [Coulson, Samantha] Univ Sunshine Coast, Fac Sci Hlth Educ & Engn, Sippy Downs, Qld 4556, Australia.
   [Lam, Yan Y.] Rutgers State Univ, Dept Biochem & Microbiol, New Brunswick, NJ 08901 USA.
   [Lam, Yan Y.] Rutgers State Univ, New Jersey Inst Food Nutr & Hlth, Sch Environm & Biol Sci, New Brunswick, NJ 08901 USA.
   [Manuel, Rachel] Univ New South Wales, Sch Med Sci, Sydney, NSW 2052, Australia.
   [Briskey, David] Univ Queensland, Sch Human Movement & Nutr Sci, Fac Hlth & Behav Sci, Brisbane, Qld 4072, Australia.
   [Kim, Ji-Nu; Ishoey, Thomas; Soto-Giron, Maria J.; Schott, Eric M.; Toledo, Gerardo] Solarea Bio Inc, Cambridge, MA 02142 USA.
C3 University of Sydney; University of Sydney; University of the Sunshine
   Coast; Rutgers State University New Brunswick; Rutgers State University
   New Brunswick; University of New South Wales Sydney; University of
   Queensland
RP Palacios, T (通讯作者)，Univ Sydney, Boden Collaborat Obes Nutr Exercise & Eating Diso, Charles Perkins Ctr, Sydney, NSW 2006, Australia.; Palacios, T (通讯作者)，Univ Sydney, Fac Med & Hlth, Sydney, NSW 2006, Australia.
EM talia.palacios@sydney.edu.au; luis.vitetta@sydney.edu.au;
   samantha.coulson@sydney.edu.au; claire.madigan@hotmail.com;
   yan.y.lam@rutgers.edu; r.manuel@unsw.edu.au; d.briskey@uq.edu.au;
   chelsea.hendy@sydney.edu.au; realkjw@gmail.com; tishoey@solareabio.com;
   jsoto@solareabio.com; eschott@solareabio.com; gtoledo@solareabio.com;
   ian.caterson@sydney.edu.au
RI Vitetta, Luis/F-4206-2010; Briskey, David R/J-7111-2016
OI Vitetta, Luis/0000-0002-7490-9298; Briskey, David R/0000-0001-9867-6700;
   Lam, Yan/0000-0002-5724-1142; Caterson, Ian/0000-0002-6139-3632;
   Soto-Giron, Maria/0000-0002-8033-8962
FU Senescyt Scholarship Program from the Ecuadorian Government; Medlab
   Clinical Ltd.
FX TP was supported by the Senescyt Scholarship Program from the Ecuadorian
   Government and the Boden Institute's NHMRC of Australia Program Grant.
   Medlab Clinical Ltd. provided the funding to develop the probiotic
   formulation and to perform the sample analysis.
CR Abubucker S, 2012, PLOS COMPUT BIOL, V8, DOI 10.1371/journal.pcbi.1002358
   ALGVERE P, 1985, BRIT J OPHTHALMOL, V69, P416, DOI 10.1136/bjo.69.6.416
   Belenguer A, 2006, APPL ENVIRON MICROB, V72, P3593, DOI 10.1128/AEM.72.5.3593-3599.2006
   Burton Jeffrey H, 2015, J Diabetes Sci Technol, V9, P808, DOI 10.1177/1932296815577425
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   Cani PD, 2009, AM J CLIN NUTR, V90, P1236, DOI 10.3945/ajcn.2009.28095
   Chan AW, 2013, ANN INTERN MED, V158, P200, DOI 10.7326/0003-4819-158-3-201302050-00583
   Chatterjee S, 2017, LANCET, V389, P2239, DOI 10.1016/S0140-6736(17)30058-2
   Chen GX, 2018, EBIOMEDICINE, V30, P317, DOI 10.1016/j.ebiom.2018.03.030
   Cox MP, 2010, BMC BIOINFORMATICS, V11, DOI 10.1186/1471-2105-11-485
   De Vadder F, 2014, CELL, V156, P84, DOI 10.1016/j.cell.2013.12.016
   Depommier C, 2020, GUT MICROBES, V11, P1231, DOI 10.1080/19490976.2020.1737307
   Dixon P, 2003, J VEG SCI, V14, P927, DOI 10.1111/j.1654-1103.2003.tb02228.x
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   FAO, EXP CONS EV HLTH NUT
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Gao D, 2009, BRIT J NUTR, V102, P1557, DOI 10.1017/S0007114509990948
   Gargari G, 2016, APPL ENVIRON MICROB, V82, P5850, DOI 10.1128/AEM.01753-16
   Grembi JA, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-58000-y
   Harte AL, 2012, DIABETES CARE, V35, P375, DOI 10.2337/dc11-1593
   Holland WL, 2017, MOL METAB, V6, P267, DOI 10.1016/j.molmet.2017.01.002
   HUNG WC, 2019, DIABETES S1, V68, DOI DOI 10.2337/DB19-1159-P
   Jayashree B, 2014, MOL CELL BIOCHEM, V388, P203, DOI 10.1007/s11010-013-1911-4
   Karczewski J, 2010, AM J PHYSIOL-GASTR L, V298, pG851, DOI 10.1152/ajpgi.00327.2009
   Karlsson F, 2013, DIABETES, V62, P3341, DOI 10.2337/db13-0844
   Kim S, 2020, APPL ENVIRON MICROB, V86, DOI 10.1128/AEM.03004-19
   Le Chatelier E, 2013, NATURE, V500, P541, DOI 10.1038/nature12506
   Li Q, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-62224-3
   Makivuokko H, 2010, BENEF MICROBES, V1, P131, DOI 10.3920/BM2009.0033
   Moreno-Navarrete JM, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0037160
   Matsuda M, 1999, DIABETES CARE, V22, P1462, DOI 10.2337/diacare.22.9.1462
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Mujagic Z, 2017, SCI REP-UK, V7, DOI 10.1038/srep40128
   Ogurtsova K, 2017, DIABETES RES CLIN PR, V128, P40, DOI 10.1016/j.diabres.2017.03.024
   Palacios T, 2017, TRIALS, V18, DOI 10.1186/s13063-016-1762-x
   Parnell JA, 2009, AM J CLIN NUTR, V89, P1751, DOI 10.3945/ajcn.2009.27465
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Ruan YT, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0132121
   */* S  62, 2011, DIABETES CARE S1, V34, pS6, DOI DOI 10.2337/DC11-S062
   Samah S, 2016, DIABETES RES CLIN PR, V118, P172, DOI 10.1016/j.diabres.2016.06.014
   Santacruz A, 2009, OBESITY, V17, P1906, DOI 10.1038/oby.2009.112
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Singleton JR, 2001, DIABETES CARE, V24, P1448, DOI 10.2337/diacare.24.8.1448
   Skoglund J, 2016, THESIS
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   SVEDLUND J, 1988, DIGEST DIS SCI, V33, P129, DOI 10.1007/BF01535722
   Tabak AG, 2012, LANCET, V379, P2279, DOI 10.1016/S0140-6736(12)60283-9
   THORBURN A, 1993, METABOLISM, V42, P780, DOI 10.1016/0026-0495(93)90249-N
   Tremaroli V, 2012, NATURE, V489, P242, DOI 10.1038/nature11552
   Truong DT, 2015, NAT METHODS, V12, P902, DOI 10.1038/nmeth.3589
   Turnbaugh PJ, 2009, NATURE, V457, P480, DOI 10.1038/nature07540
   van Zanten GC, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0047212
   Vita P, 2016, DIABETES RES CLIN PR, V112, P13, DOI 10.1016/j.diabres.2015.11.010
   Wu FF, 2020, ANAEROBE, V61, DOI 10.1016/j.anaerobe.2019.102138
   Zhang QQ, 2016, MEDICINA-LITHUANIA, V52, P28, DOI 10.1016/j.medici.2015.11.008
   Zhang X, 2015, SCI REP-UK, V5, DOI 10.1038/srep14405
   Zhao LP, 2018, SCIENCE, V359, P1151, DOI 10.1126/science.aao5774
   Zupancic ML, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0043052
NR 58
TC 37
Z9 37
U1 3
U2 31
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUL
PY 2020
VL 12
IS 7
AR 2041
DI 10.3390/nu12072041
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA MT0CL
UT WOS:000554638700001
PM 32660025
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Isnard, S
   Lin, J
   Fombuena, B
   Ouyang, J
   Varin, TV
   Richard, C
   Marette, A
   Ramendra, R
   Planas, D
   Marchand, LR
   Messaoudene, M
   Van der Ley, CP
   Kema, IP
   Ahmed, DS
   Zhang, YL
   Finkelman, M
   Routy, B
   Angel, J
   Ancuta, P
   Routy, JP
AF Isnard, Stephane
   Lin, John
   Fombuena, Brandon
   Ouyang, Jing
   Varin, Thibault V.
   Richard, Corentin
   Marette, Andre
   Ramendra, Rayoun
   Planas, Delphine
   Marchand, Laurence Raymond
   Messaoudene, Meriem
   Van der Ley, Claude P.
   Kema, Ido P.
   Ahmed, Darakhshan Sohail
   Zhang, Yonglong
   Finkelman, Malcolm
   Routy, Bertrand
   Angel, Jonathan
   Ancuta, Petronela
   Routy, Jean-Pierre
TI Repurposing Metformin in Nondiabetic People With HIV: Influence on
   Weight and Gut Microbiota
SO OPEN FORUM INFECTIOUS DISEASES
LA English
DT Article
DE HIV; metformin; microbiota; nondiabetic; weight
ID SYSTEMIC IMMUNE ACTIVATION; AKKERMANSIA-MUCINIPHILA; INFLAMMATORY
   RESPONSE; INFECTION; RISK; GAIN; TRANSLOCATION; BUTYRATE; DISEASE;
   CANCER
AB Background. People with HIV (PWH) taking antiretroviral therapy (ART) may experience weight gain, dyslipidemia, increased risk of non-AIDS comorbidities, and long-term alteration of the gut microbiota. Both low CD4/CD8 ratio and chronic inflammation have been associated with changes in the gut microbiota of PWH. The antidiabetic drug metformin has been shown to improve gut microbiota composition while decreasing weight and inflammation in diabetes and polycystic ovary syndrome. Nevertheless, it remains unknown whether metformin may benefit PWH receiving ART, especially those with a low CD4/CD8 ratio.
   Methods. In the Lilac pilot trial, we recruited 23 nondiabetic PWI I receiving ART for more than 2 years with a low CD4/CD8 ratio (<0.7). Blood and stool samples were collected during study visits at baseline, after a 12-week metformin treatment, and 12 weeks after discontinuation. Microbiota composition was analyzed by 16S rDNA gene sequencing, and markers of inflammation were assessed in plasma.
   Results. Metformin decreased weight in PWH, and weight loss was inversely correlated with plasma levels of the satiety factor GDF-15. Furthermore, metformin changed the gut microbiota composition by increasing the abundance of anti-inflammatory bacteria such as butyrate-producing species and the protective Akkermansia muciniphila.
   Conclusions. Our study provides the first evidence that a 12-week metformin treatment decreased weight and favored anti-inflammatory bacteria abundance in the microbiota of nondiabetic ART-treated PWH. Larger randomized placebo-controlled clinical trials with longer metformin treatment will be needed to further investigate the role of metformin in reducing inflammation and the risk of non-AIDS comorbidities in ART-treated PWH.
C1 [Isnard, Stephane; Lin, John; Fombuena, Brandon; Ouyang, Jing; Ramendra, Rayoun; Ahmed, Darakhshan Sohail; Routy, Jean-Pierre] McGill Univ Hlth Ctr, Res Inst, Infect Dis & Immun Global Hlth Program, Montreal, PQ, Canada.
   [Isnard, Stephane; Lin, John; Fombuena, Brandon; Ouyang, Jing; Ramendra, Rayoun; Ahmed, Darakhshan Sohail; Routy, Jean-Pierre] McGill Univ Hlth Ctr, Chron Viral Illness Serv, Montreal, PQ, Canada.
   [Isnard, Stephane] CIHR Canadian HIV Trials Network, Vancouver, BC, Canada.
   [Ramendra, Rayoun] Univ Toronto, Fac Med, Toronto, ON, Canada.
   [Ouyang, Jing] Chongqing Publ Hlth Med Ctr, Chongqing, Peoples R China.
   [Varin, Thibault V.; Marette, Andre] Laval Univ, Inst Nutr & Funct Foods, Quebec City, PQ, Canada.
   [Richard, Corentin; Planas, Delphine; Marchand, Laurence Raymond; Routy, Bertrand; Ancuta, Petronela] Univ Montreal, Ctr Rech Ctr Hosp, Montreal, PQ, Canada.
   [Planas, Delphine; Ancuta, Petronela] Univ Montreal, Fac Med, Dept Microbiol Infectiol & Immunol, Montreal, PQ, Canada.
   [Marette, Andre] Laval Univ, Fac Med, Cardiol Axis Quebec Heart & Lung Inst, Dept Med, Quebec City, PQ, Canada.
   [Messaoudene, Meriem; Van der Ley, Claude P.; Kema, Ido P.] Univ Groningen, Univ Med Ctr Groningen, Dept Lab Med, Groningen, Netherlands.
   [Zhang, Yonglong; Finkelman, Malcolm] Associates Cape Cod Inc, Falmouth, MA USA.
   [Angel, Jonathan] Univ Ottawa, Ottawa Hosp, Ottawa, ON, Canada.
   [Routy, Jean-Pierre] McGill Univ Hlth Ctr, Div Hematol, Montreal, PQ, Canada.
   [Routy, Bertrand] Univ Montreal Healthcare Ctr, Dept Hematooncol, Div Med, Montreal, PQ, Canada.
C3 McGill University; McGill University; University of Toronto; Laval
   University; Universite de Montreal; Universite de Montreal; Laval
   University; Quebec Heart & Lung Institute; University of Groningen;
   University of Ottawa; Ottawa Hospital Research Institute; McGill
   University
RP Routy, JP (通讯作者)，McGill Univ, McGill Univ Hlth Ctr, Res Inst, Glen Site,1001 Blvd Marie,3-3232, Montreal, PQ H4A 3J1, Canada.
EM jean-pierre.routy@mcgill.ca
RI Marette, Andre/E-9342-2013
OI Planas, Delphine/0000-0002-2509-9954; Ramendra,
   Rayoun/0000-0002-1452-8231; Lin, John/0000-0002-2596-969X; Marette,
   Andre/0000-0003-3950-5973
FU Vaccines & Immunotherapies core of the HIV clinical trial network from
   the Canadian Institute for Health Research (CIHR CTN) [PT07]; CIHR [MOP
   103230, PTJ 166049]; CanCURE 2.0 CIHR [HB2-164064]; Fond de Recherche
   Quebec Sante fellowship; CIHR/CTN Postdoctoral Fellowship Award
FX This work was supported by the Vaccines & Immunotherapies core of the
   HIV clinical trial network from the Canadian Institute for Health
   Research (CIHR CTN PT07), a CIHR grant (MOP 103230 and PTJ 166049), a
   CanCURE 2.0 CIHR grant (HB2-164064). Dr Stephane Isnard is supported by
   a Fond de Recherche Quebec Sante fellowship and a CIHR/CTN Postdoctoral
   Fellowship Award.
CR Achhra AC, 2016, HIV MED, V17, P255, DOI 10.1111/hiv.12294
   Alzahrani J, 2019, EBIOMEDICINE, V46, P522, DOI 10.1016/j.ebiom.2019.07.027
   Anhe FF, 2019, GUT, V68, P453, DOI 10.1136/gutjnl-2017-315565
   Arrieta O, 2019, JAMA ONCOL, V5, DOI 10.1001/jamaoncol.2019.2553
   Belzer C, 2017, MBIO, V8, DOI [10.1128/mBio.00770-17, 10.1128/mbio.00770-17]
   Brenchley JM, 2006, NAT MED, V12, P1365, DOI 10.1038/nm1511
   Bryrup T, 2019, DIABETOLOGIA, V62, P1024, DOI 10.1007/s00125-019-4848-7
   Callahan BJ, 2016, NAT METHODS, V13, P581, DOI [10.1038/NMETH.3869, 10.1038/nmeth.3869]
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Chang PV, 2014, P NATL ACAD SCI USA, V111, P2247, DOI 10.1073/pnas.1322269111
   Chia LW, 2018, ANTON LEEUW INT J G, V111, P859, DOI 10.1007/s10482-018-1040-x
   Coll AP, 2020, NATURE, V578, P444, DOI 10.1038/s41586-019-1911-y
   Coretti L, 2017, MEDIAT INFLAMM, V2017, DOI 10.1155/2017/8392523
   Day EA, 2019, NAT METAB, V1, P1202, DOI 10.1038/s42255-019-0146-4
   De Smet K, 2005, BIOTECHNOL LETT, V27, P1337, DOI 10.1007/s10529-005-0936-5
   Depommier C, 2019, NAT MED, V25, P1096, DOI 10.1038/s41591-019-0495-2
   Derosa G, 2017, DRUG DES DEV THER, V11, P1481, DOI 10.2147/DDDT.S131670
   Di Francesco A, 2018, SCIENCE, V362, P770, DOI 10.1126/science.aau2095
   Dillon SM, 2014, MUCOSAL IMMUNOL, V7, P983, DOI 10.1038/mi.2013.116
   Eckard AR, 2020, CURR OPIN INFECT DIS, V33, P10, DOI 10.1097/QCO.0000000000000616
   Elbere I, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0204317
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Gelpi M, CLIN INFECT DIS
   Gomez M, 2019, INFECTION, V47, P95, DOI 10.1007/s15010-018-1227-0
   Harper W, 2015, CAN J DIABETES, V39, P250, DOI 10.1016/j.jcjd.2015.05.009
   Herrin M, 2016, JAIDS-J ACQ IMM DEF, V73, P228, DOI 10.1097/QAI.0000000000001071
   Hill A, 2020, C RETR OPP INF
   Hirsch HA, 2013, P NATL ACAD SCI USA, V110, P972, DOI 10.1073/pnas.1221055110
   Hsu DC, 2016, DRUGS, V76, P533, DOI 10.1007/s40265-016-0546-7
   Kechin A, 2017, J COMPUT BIOL, V24, P1138, DOI 10.1089/cmb.2017.0096
   Kim SA, 2012, BIOCHEM BIOPH RES CO, V425, P866, DOI 10.1016/j.bbrc.2012.07.165
   Li SN, 2009, HEART VESSELS, V24, P446, DOI 10.1007/s00380-008-1137-7
   Li Z, 2018, GUT, V67, P1269, DOI 10.1136/gutjnl-2017-314050
   Liu H, 2018, ADV NUTR, V9, P21, DOI 10.1093/advances/nmx009
   LOVE MI, 2014, GENOME BIOL, V15, DOI DOI 10.1186/S13059-014-0550-8
   Lozupone CA, 2013, CELL HOST MICROBE, V14, P329, DOI 10.1016/j.chom.2013.08.006
   Lu W, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.01451
   Marchetti G, 2013, CLIN MICROBIOL REV, V26, P2, DOI 10.1128/CMR.00050-12
   Martin-Montalvo A, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms3192
   McMurdie PJ, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0061217
   Meade KG, 2019, FRONT IMMUNOL, V9, DOI 10.3389/fimmu.2018.03072
   Mehraj V, 2017, J VIRUS ERAD, V3, P212
   Morse CG, 2006, JAMA-J AM MED ASSOC, V296, P844, DOI 10.1001/jama.296.7.844
   Mutlu EA, 2014, PLOS PATHOG, V10, DOI 10.1371/journal.ppat.1003829
   Neff CP, 2018, EBIOMEDICINE, V30, P192, DOI 10.1016/j.ebiom.2018.03.024
   Norwood J, 2017, JAIDS-J ACQ IMM DEF, V76, P527, DOI [10.1097/QAI.0000000000001525, 10.1097/qai.0000000000001525]
   Nowak P, 2015, AIDS, V29, P2409, DOI 10.1097/QAD.0000000000000869
   O'Neill TJ, 2017, JAIDS-J ACQ IMM DEF, V75, P439, DOI 10.1097/QAI.0000000000001433
   Onken B, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0008758
   Ouyang J, 2020, FRONT IMMUNOL, V11, DOI 10.3389/fimmu.2020.00645
   Ouyang J, 2020, AIDS RES THER, V17, DOI 10.1186/s12981-020-00267-2
   Pilon G, 2004, J BIOL CHEM, V279, P20767, DOI 10.1074/jbc.M401390200
   Pollak M, 2017, DIABETOLOGIA, V60, P1662, DOI 10.1007/s00125-017-4352-x
   Pranger IG, 2019, NUTR REV, V77, P46, DOI 10.1093/nutrit/nuy048
   Quast Christian, 2013, Nucleic Acids Res, V41, pD590, DOI 10.1093/nar/gks1219
   Ramendra R, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.00465
   Reunanen J, 2015, APPL ENVIRON MICROB, V81, P3655, DOI 10.1128/AEM.04050-14
   Roberti MP, 2020, NAT MED, V26, P919, DOI 10.1038/s41591-020-0882-8
   Rocafort M, 2019, MICROBIOME, V7, DOI 10.1186/s40168-019-0687-5
   Rosario D, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.00775
   Routy JP, 2019, BMJ OPEN, V9, DOI 10.1136/bmjopen-2018-028444
   Sax PE, CLIN INFECT DIS
   Segata N, 2011, GENOME BIOL, V12, DOI 10.1186/gb-2011-12-6-r60
   Serrano-Villar S, 2014, PLOS PATHOG, V10, DOI 10.1371/journal.ppat.1004078
   SESSA L, 2019, AIDS, DOI DOI 10.1097/QAD.0000000000002131
   Sharma A, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0143740
   Shikuma CM, 2020, AIDS RES HUM RETROV, V36, P303, DOI [10.1089/aid.2019.0078, 10.1089/AID.2019.0078]
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Stekovic S, 2019, CELL METAB, V30, P462, DOI 10.1016/j.cmet.2019.07.016
   SUM CF, 1992, DIABETIC MED, V9, P61, DOI 10.1111/j.1464-5491.1992.tb01716.x
   Vazquez-Castellanos JF, 2015, MUCOSAL IMMUNOL, V8, P760, DOI 10.1038/mi.2014.107
   Vazquez-Castellanos JF, 2018, ISME J, V12, P1964, DOI 10.1038/s41396-018-0151-8
   Vesterbacka J, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-06675-1
   Victor VM, 2015, ATHEROSCLEROSIS, V242, P167, DOI 10.1016/j.atherosclerosis.2015.07.017
   Vuille-Lessard E, 2016, AIDS, V30, P2635, DOI 10.1097/QAD.0000000000001241
   Vujkovic-Cvijin I, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-16222-8
   Vujkovic-Cvijin I, 2019, CURR HIV-AIDS REP, V16, P204, DOI 10.1007/s11904-019-00441-w
   Vujkovic-Cvijin I, 2013, SCI TRANSL MED, V5, DOI 10.1126/scitranslmed.3006438
   Wang Q, 2007, APPL ENVIRON MICROB, V73, P5261, DOI 10.1128/AEM.00062-07
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Zong J, 2014, J INT AIDS SOC, V17, P65, DOI 10.7448/IAS.17.4.19584
NR 82
TC 20
Z9 20
U1 0
U2 0
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 2328-8957
J9 OPEN FORUM INFECT DI
JI Open Forum Infect. Dis.
PD SEP
PY 2020
VL 7
IS 9
AR ofaa338
DI 10.1093/ofid/ofaa338
PG 10
WC Immunology; Infectious Diseases; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Infectious Diseases; Microbiology
GA OW8JU
UT WOS:000593127000014
PM 32964062
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Liang, HY
   Song, H
   Zhang, XJ
   Song, GF
   Wang, YZ
   Ding, XF
   Duan, XG
   Li, LF
   Sun, TW
   Kan, QC
AF Liang, Huoyan
   Song, Heng
   Zhang, Xiaojuan
   Song, Gaofei
   Wang, Yuze
   Ding, Xianfei
   Duan, Xiaoguang
   Li, Lifeng
   Sun, Tongwen
   Kan, Quancheng
TI Metformin attenuated sepsis-related liver injury by modulating gut
   microbiota
SO EMERGING MICROBES & INFECTIONS
LA English
DT Article
DE Sepsis-related liver injury; aged rats; metformin; gut microbiota; CLP
ID CHAIN FATTY-ACIDS; AUTOPHAGY; MICE; DIET
AB Increased evidence shows that gut microbiota acts as the primary regulator of the liver; however, its role in sepsis-related liver injury (SLI) in the elderly is unclear. This study assessed whether metformin could attenuate SLI by modulating gut microbiota in septic-aged rats. Cecal ligation and puncture (CLP) was used to induce SLI in aged rats. Fecal microbiota transplantation (FMT) was used to validate the roles of gut microbiota in these pathologies. The composition of gut microbiota was analysed by 16S rRNA sequencing. Moreover, the liver and colon tissues were analysed by histopathology, immunofluorescence, immunohistochemistry, and reverse transcription polymerase chain reaction (RT-PCR). Metformin improved liver damage, colon barrier dysfunction in aged SLI rats. Moreover, metformin improved sepsis-induced liver inflammation and damage under gut microbiota. Importantly, FMT assay showed that rats gavaged with faeces from metformin-treated SLI rats displayed less severe liver damage and colon barrier dysfunctions than those gavaged with faeces from SLI rats. The gut microbiota composition among the sham-operated, CLP-operated and metformin-treated SLI rats was different. In particular, the proportion of Klebsiella and Escherichia_Shigella was higher in SLI rats than sham-operated and metformin-treated SLI rats; while metformin could increase the proportion of Bifidobacterium, Muribaculaceae, Parabacteroides_distasonis and Alloprevitella in aged SLI rats. Additionally, Klebsiella and Escherichia_Shigella correlated positively with the inflammatory factors in the liver. Our findings suggest that metformin may improve liver injury by regulating the gut microbiota and alleviating colon barrier dysfunction in septic-aged rats, which may be an effective therapy for SLI.
C1 [Liang, Huoyan; Song, Heng; Zhang, Xiaojuan; Song, Gaofei; Wang, Yuze; Ding, Xianfei; Duan, Xiaoguang; Sun, Tongwen] Zhengzhou Univ, Gen ICU, Affiliated Hosp 1,Henan Engn Res Ctr Crit Care Me, Henan Key Lab Crit Care Med,Zhengzhou Key Lab Sep, Zhengzhou, Peoples R China.
   [Liang, Huoyan; Song, Heng; Song, Gaofei; Sun, Tongwen] Zhengzhou Univ, Acad Med Sci, Zhengzhou, Peoples R China.
   [Li, Lifeng] Zhengzhou Univ, Dept Pharm, Internet Med & Syst Applicat Natl Engn Lab, Affiliated Hosp 1, Zhengzhou, Peoples R China.
   [Kan, Quancheng] Zhengzhou Univ, Dept Pharm, Affiliated Hosp 1, Zhengzhou, Peoples R China.
C3 Zhengzhou University; Zhengzhou University; Zhengzhou University;
   Zhengzhou University
RP Sun, TW (通讯作者)，Zhengzhou Univ, Gen ICU, Affiliated Hosp 1,Henan Engn Res Ctr Crit Care Me, Henan Key Lab Crit Care Med,Zhengzhou Key Lab Sep, Zhengzhou, Peoples R China.; Kan, QC (通讯作者)，Zhengzhou Univ, Dept Pharm, Affiliated Hosp 1, Zhengzhou, Peoples R China.
EM suntongwen@163.com; kanqc@zzu.edu.cn
RI Sun, Tongwen/AAQ-7741-2020; Duan, Xiaoguang/O-2980-2017
OI Duan, Xiaoguang/0000-0001-9635-5807; Li, Lifeng/0000-0002-7492-4017
FU United Fund of National Natural Science Foundation of China [U2004110];
   National Natural Science Foundation of China [82172129]; 2021 Youth
   Talent Promotion Project in Henan Province [2021HYTP053]; 2021 joint
   construction project of Henan Medical Science and Technology
   Breakthrough Plan [LHGJ20210299]
FX This study was supported by the United Fund of National Natural Science
   Foundation of China (grant number U2004110), the National Natural
   Science Foundation of China (grant number 82172129), the 2021 Youth
   Talent Promotion Project in Henan Province (grant number 2021HYTP053),
   the 2021 joint construction project of Henan Medical Science and
   Technology Breakthrough Plan (grant number LHGJ20210299).
CR Ahmadi S, 2020, J GERONTOL A-BIOL, V75, pE9, DOI 10.1093/gerona/glaa056
   Savio LEB, 2017, J HEPATOL, V67, P716, DOI 10.1016/j.jhep.2017.05.021
   Barzilai N, 2016, CELL METAB, V23, P1060, DOI 10.1016/j.cmet.2016.05.011
   Bharath LP, 2020, CELL METAB, V32, P44, DOI 10.1016/j.cmet.2020.04.015
   Bryrup T, 2019, DIABETOLOGIA, V62, P1024, DOI 10.1007/s00125-019-4848-7
   Buchman TG, 2020, CRIT CARE MED, V48, P276, DOI 10.1097/CCM.0000000000004224
   Buford TW, 2018, GEROSCIENCE, V40, P257, DOI 10.1007/s11357-018-0026-y
   Buford TW, 2017, MICROBIOME, V5, DOI 10.1186/s40168-017-0296-0
   Buse JB, 2016, DIABETES CARE, V39, P198, DOI 10.2337/dc15-0488
   Cabreiro F, 2013, CELL, V153, P228, DOI 10.1016/j.cell.2013.02.035
   Chen YX, 2019, ADV EXP MED BIOL, V1128, P103, DOI 10.1007/978-981-13-3540-2_6
   Claesson MJ, 2012, NATURE, V488, P178, DOI 10.1038/nature11319
   Cornick S, 2015, TISSUE BARRIERS, V3, DOI 10.4161/21688370.2014.982426
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   DeFronzo R, 2016, METABOLISM, V65, P20, DOI 10.1016/j.metabol.2015.10.014
   DeMerle KM, 2021, CRIT CARE MED, V49, P748, DOI 10.1097/CCM.0000000000004842
   Douglas GM, 2020, NAT BIOTECHNOL, V38, P685, DOI 10.1038/s41587-020-0548-6
   Elbere I, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0204317
   Fajgenbaum DC, 2020, NEW ENGL J MED, V383, P2255, DOI 10.1056/NEJMra2026131
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Gong SH, 2019, HEPATOLOGY, V69, P1751, DOI 10.1002/hep.30361
   Hassan FI, 2020, CELL J, V21, P363, DOI 10.22074/cellj.2020.6286
   Honda K, 2016, NATURE, V535, P75, DOI 10.1038/nature18848
   Inghammar M, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0243990
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kelly CJ, 2015, CELL HOST MICROBE, V17, P662, DOI 10.1016/j.chom.2015.03.005
   Koh A, 2016, CELL, V165, P1332, DOI 10.1016/j.cell.2016.05.041
   Koh GY, 2020, CARCINOGENESIS, V41, P909, DOI 10.1093/carcin/bgaa018
   Koh GY, 2018, INT J CANCER, V143, P1797, DOI 10.1002/ijc.31559
   Kong C, 2019, NUTRITION, V60, P175, DOI 10.1016/j.nut.2018.10.002
   Li D, 2018, AGING CELL, V17, DOI 10.1111/acel.12768
   Liang HY, 2019, EXP CELL RES, V383, DOI 10.1016/j.yexcr.2019.06.010
   Liu ZG, 2019, FASEB J, V33, P12299, DOI 10.1096/fj.201900398RR
   Luo YP, 2014, INT IMMUNOPHARMACOL, V20, P24, DOI 10.1016/j.intimp.2014.02.017
   Mariat D, 2009, BMC MICROBIOL, V9, DOI 10.1186/1471-2180-9-123
   Moiseeva O, 2013, AGING CELL, V12, P489, DOI 10.1111/acel.12075
   Mouries J, 2019, J HEPATOL, V71, P1216, DOI 10.1016/j.jhep.2019.08.005
   Nakano H, 2020, NUTRIENTS, V12, DOI 10.3390/nu12113252
   Pryor R, 2019, CELL, V178, P1299, DOI 10.1016/j.cell.2019.08.003
   Rampelli S, 2013, AGING-US, V5, P902, DOI 10.18632/aging.100623
   Rhee SI, 2014, INTEST RES, V12, P90, DOI 10.5217/ir.2014.12.2.90
   Schuijt TJ, 2016, GUT, V65, P575, DOI 10.1136/gutjnl-2015-309728
   Song YM, 2015, AUTOPHAGY, V11, P46, DOI 10.4161/15548627.2014.984271
   Sun J, 2020, CRIT CARE, V24, DOI 10.1186/s13054-020-03327-1
   Sun JY, 2020, STEM CELL RES THER, V11, DOI 10.1186/s13287-020-01902-5
   Titov AA, 2019, J IMMUNOL, V203, P338, DOI 10.4049/jimmunol.1801651
   Wang KC, 2020, MSPHERE, V5, DOI 10.1128/mSphere.00791-19
   Whang A, 2019, EBIOMEDICINE, V39, P591, DOI 10.1016/j.ebiom.2018.11.046
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Yatsunenko T, 2012, NATURE, V486, P222, DOI 10.1038/nature11053
   Zhang X, 2015, SCI REP-UK, V5, DOI 10.1038/srep14405
   Zhou D, 2017, WORLD J GASTROENTERO, V23, P60, DOI 10.3748/wjg.v23.i1.60
NR 52
TC 18
Z9 19
U1 10
U2 67
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
EI 2222-1751
J9 EMERG MICROBES INFEC
JI Emerg. Microbes Infect.
PD DEC 31
PY 2022
VL 11
IS 1
BP 815
EP 828
DI 10.1080/22221751.2022.2045876
PG 14
WC Immunology; Infectious Diseases; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Infectious Diseases; Microbiology
GA ZT7GG
UT WOS:000769319600001
PM 35191819
OA Green Published, Green Submitted, gold
DA 2023-06-08
ER

PT J
AU Van Syoc, E
   Weaver, E
   Rogers, CJ
   Silverman, JD
   Ramachandran, R
   Ganda, E
AF Van Syoc, Emily
   Weaver, Evelyn
   Rogers, Connie J.
   Silverman, Justin D.
   Ramachandran, Ramesh
   Ganda, Erika
TI Metformin modulates the gut microbiome in broiler breeder hens
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Article
DE broiler breeder hens; gut microbiome; metformin; polycystic ovary
   syndrome (PCOS); poultry
ID POLYCYSTIC-OVARY-SYNDROME; DOUBLE-BLIND; ENDOCRINE; WOMEN; THERAPY
AB Broiler breeder hens, the parent stock of commercial broiler chickens, are genetically selected for rapid growth. Due to a longer production period and the focus of genetic selection on superior carcass traits in their progeny, these hens have the propensity to gain excess adipose tissue and exhibit severe ovarian dysfunction, a phenotype that is similar to human polycystic ovary syndrome (PCOS). Metformin is an antihyperglycemic drug approved for type 2 diabetes that is prescribed off-label for PCOS with benefits on metabolic and reproductive health. An additional effect of metformin treatments in humans is modulation of gut microbiome composition, hypothesized to benefit glucose sensitivity and systemic inflammation. The effects of dietary metformin supplementation in broiler breeder hens have not been investigated, thus we hypothesized that dietary metformin supplementation would alter the gut microbiome of broiler breeder hens. Broiler breeder hens were supplemented with metformin at four different levels (0, 25, 50, and 75 mg/kg body weight) from 25 to 65 weeks of age, and a subset of hens (n = 8-10 per treatment group) was randomly selected to undergo longitudinal microbiome profiling with 16S rRNA sequencing. Metformin impacted the microbial community composition in 75 mg/kg metformin compared to controls (adjusted PERMANOVA p = 0.0006) and an additional dose-dependent difference was observed between 25 mg/kg and 75 mg/kg (adjusted PERMANOVA p = 0.001) and between 50 mg/kg and 75 mg/kg (adjusted PERMANOVA p = 0.001) but not between 25 mg/kg and 50 mg/kg (adjusted PERMANOVA p = 0.863). There were few differences in the microbiome attributed to hen age, and metformin supplementation did not alter alpha diversity. Bacteria that were identified as differentially relatively abundant between 75 mg/kg metformin treatment and the control, and between metformin doses, included Ruminococcus and members of the Clostridia family that have been previously identified in human trials of PCOS. These results demonstrate that metformin impacts the microbiome of broiler breeder hens in a dose-dependent manner and several findings were consistent with PCOS in humans and with metformin treatment in type 2 diabetes. Metformin supplementation is a potentially promising option to improve gut health and reproductive efficiency in broiler breeder hens.
C1 [Van Syoc, Emily] Penn State Univ, Integrat & Biomed Physiol & Clin & Translat Sci Du, University Pk, PA USA.
   [Van Syoc, Emily; Weaver, Evelyn; Ganda, Erika] Penn State Univ, Dept Anim Sci, University Pk, PA 16801 USA.
   [Van Syoc, Emily; Ganda, Erika] Penn State Univ, Microbiome Ctr, University Pk, PA 16801 USA.
   [Weaver, Evelyn; Ramachandran, Ramesh] Penn State Univ, Ctr Reprod Biol & Hlth, University Pk, PA USA.
   [Rogers, Connie J.] Penn State Univ, Dept Nutr Sci, University Pk, PA USA.
   [Rogers, Connie J.] Penn State Canc Inst, Hershey, PA USA.
   [Silverman, Justin D.] Penn State Univ, Dept Stat, University Pk, PA USA.
   [Silverman, Justin D.] Penn State Univ, Dept Med, University Pk, PA USA.
   [Silverman, Justin D.] Penn State Univ, Inst Computat & Data Sci, University Pk, PA USA.
   [Silverman, Justin D.] Penn State Univ, Coll Informat Sci & Technol, University Pk, PA USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE);
   Pennsylvania State University; Pennsylvania State University -
   University Park; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); Pennsylvania State University; Pennsylvania State University -
   University Park; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); Pennsylvania State University; Pennsylvania State University -
   University Park; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); Pennsylvania State University; Pennsylvania State University -
   University Park; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); Pennsylvania State University; Pennsylvania State University -
   University Park; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); Pennsylvania State University; Penn State Health; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); Pennsylvania State
   University; Pennsylvania State University - University Park;
   Pennsylvania Commonwealth System of Higher Education (PCSHE);
   Pennsylvania State University; Pennsylvania State University -
   University Park; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); Pennsylvania State University; Pennsylvania State University -
   University Park; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); Pennsylvania State University; Pennsylvania State University -
   University Park
RP Ganda, E (通讯作者)，Penn State Univ, Dept Anim Sci, University Pk, PA 16801 USA.; Ganda, E (通讯作者)，Penn State Univ, Microbiome Ctr, University Pk, PA 16801 USA.
EM ganda@psu.edu
OI Rogers, Connie J/0000-0003-4072-2721; Van Syoc,
   Emily/0000-0002-9984-534X; Ganda, Erika/0000-0002-8735-0753
FU PSU/NIDDK; USDA National Institute of Food and Agriculture and Hatch
   Appropriations [T32DK120509]; USDA National Institute of Food and
   Agriculture [PEN04752, 1023328]; NIH [T32DK120509];  [2017-67015-26506];
    [T32GM108563]
FX EVS was supported on the PSU/NIDDK funded "Integrative Analysis of
   Metabolic Phenotypes (IAMP) Predoctoral Training Program (T32DK120509)."
   This work was supported by the USDA National Institute of Food and
   Agriculture and Hatch Appropriations under Project #PEN04752 Accession
   #1023328 and by startup funds from EG. A part of this project was
   supported by Agriculture and Food Research Initiative Competitive Grant
   No. 2017-67015-26506 from the USDA National Institute of Food and
   Agriculture funded to RR and in part, by NIH Grant T32GM108563.
CR Amer Diabet Assoc, 2014, DIABETES CARE, V37, pS81, DOI [10.2337/dc13-S067, 10.2337/dc14-S081, 10.2337/dc13-S011, 10.2337/dc10-S062, 10.2337/dc10-S011, 10.2337/dc11-S062, 10.2337/dc12-s064, 10.2337/dc11-S011]
   Ashwell CM, 2003, POULTRY SCI, V82, P106, DOI 10.1093/ps/82.1.106
   Baker JM, 2017, MATURITAS, V103, P45, DOI 10.1016/j.maturitas.2017.06.025
   Barnett D., 2021, J OPEN SOURCE SOFTW, V6, P3201, DOI DOI 10.21105/JOSS.03201
   Bolger AM, 2014, BIOINFORMATICS, V30, P2114, DOI 10.1093/bioinformatics/btu170
   Bosi E, 2009, DIABETES OBES METAB, V11, P3, DOI 10.1111/j.1463-1326.2008.01031.x
   Brussow H, 2020, MICROB BIOTECHNOL, V13, P423, DOI 10.1111/1751-7915.13479
   Callahan BJ, 2016, NAT METHODS, V13, P581, DOI [10.1038/NMETH.3869, 10.1038/nmeth.3869]
   Center for Drug Evaluation and Research, 1995, APPR LETT GLUC TABL
   Clavijo V, 2018, POULTRY SCI, V97, P1006, DOI 10.3382/ps/pex359
   Decuypere E, 2010, BRIT POULTRY SCI, V51, P569, DOI 10.1080/00071668.2010.519121
   Diaz-Sanchez S, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0216080
   Elbere I, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0241338
   Ewels P, 2016, BIOINFORMATICS, V32, P3047, DOI 10.1093/bioinformatics/btw354
   Federation W.H.O.I.D., 2006, DEF DIAGN DIAB MELL
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Gloor GB, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.02224
   Guan YY, 2020, INT J ENDOCRINOL, V2020, DOI 10.1155/2020/5150684
   Johnson PA, 2012, REPROD DOMEST ANIM, V47, P283, DOI 10.1111/j.1439-0531.2012.02087.x
   Johnson PA, 2009, REPRODUCTION, V137, P857, DOI 10.1530/REP-08-0406
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kassambara Alboukadel, 2020, CRAN
   Kers JG, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.00235
   Maniar K, 2017, PHARMACOL RES, V117, P103, DOI 10.1016/j.phrs.2016.12.003
   Martin M., 2011, EMBNET J, V17, P10, DOI DOI 10.14806/EJ.17.1.200
   McMurdie PJ, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0061217
   Moghetti P, 2000, J CLIN ENDOCR METAB, V85, P139, DOI 10.1210/jc.85.1.139
   Morin-Papunen LC, 1998, FERTIL STERIL, V69, P691, DOI 10.1016/S0015-0282(98)00011-9
   Munoz-Price LS, 2008, NEW ENGL J MED, V358, P1271, DOI 10.1056/NEJMra070741
   Quast C, 2013, NUCLEIC ACIDS RES, V41, pD590, DOI 10.1093/nar/gks1219
   Rizk MG, 2021, J ENDOCR SOC, V5, DOI 10.1210/jendso/bvaa177
   Rodriguez J, 2018, CURR OPIN CLIN NUTR, V21, P294, DOI 10.1097/MCO.0000000000000468
   Rychlik I, 2020, ANIMALS-BASEL, V10, DOI 10.3390/ani10010103
   Shen W, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0163962
   Stirling C, 2010, BMC HEALTH SERV RES, V10, DOI 10.1186/1472-6963-10-122
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Trudeau S, 2020, FRONT MICROBIOL, V11, DOI 10.3389/fmicb.2020.00666
   van Santbrink EJP, 2005, EUR J ENDOCRINOL, V152, P611, DOI 10.1530/eje.1.01866
   VELAZQUEZ EM, 1994, METABOLISM, V43, P647, DOI 10.1016/0026-0495(94)90209-7
   Weaver EA, 2022, bioRxiv, DOI [10.1101/2022.07.13.499919, DOI 10.1101/2022.07.13.499919]
   Weaver EA, 2020, REPRODUCTION, V160, P659, DOI 10.1530/REP-20-0066
   Wickham H, 2009, USE R, P1, DOI 10.1007/978-0-387-98141-3_1
   Wilkins LJ, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-49452-y
   Wirbel J, 2019, NAT MED, V25, P679, DOI 10.1038/s41591-019-0406-6
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Xing C, 2020, J CLIN ENDOCR METAB, V105, P2950, DOI 10.1210/clinem/dgaa337
   YU MW, 1992, POULTRY SCI, V71, P1750, DOI 10.3382/ps.0711750
   Yurtdas G, 2020, J AM COLL NUTR, V39, P371, DOI 10.1080/07315724.2019.1657515
   Zhang YF, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-18414-8
   Zuidhof MJ, 2014, POULTRY SCI, V93, P2970, DOI 10.3382/ps.2014-04291
NR 50
TC 0
Z9 0
U1 1
U2 3
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD SEP 14
PY 2022
VL 13
AR 1000144
DI 10.3389/fphys.2022.1000144
PG 10
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 5C1BQ
UT WOS:000864001900001
PM 36203937
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Li, RF
   Yao, YR
   Gao, PF
   Bu, SR
AF Li, Ruifang
   Yao, Yurong
   Gao, Pengfei
   Bu, Shurui
TI The Therapeutic Efficacy of Curcumin vs. Metformin in Modulating the Gut
   Microbiota in NAFLD Rats: A Comparative Study
SO FRONTIERS IN MICROBIOLOGY
LA English
DT Article
DE non-alcoholic fatty liver disease; curcumin; metformin; gut microbiota;
   short-chain fatty acids
ID FATTY LIVER-DISEASE; OBESITY; MECHANISMS; STEATOSIS; ACIDS; DIET
AB Structural disruption of gut microbiota is closely related to the occurrence of non-alcoholic fatty liver disease (NAFLD). Previous research has demonstrated that both curcumin (CUR) and metformin (MET) have a therapeutic effect against NAFLD and play a role in modulating the gut microbiota. However, there is a lack of direct comparison between the two medications in terms of the therapeutic efficacy and the regulatory effect on gut microbiota. In this study, we administered either CUR or MET to rats with high-fat diet (HFD)-induced obesity to observe changes in body parameters, biochemical parameters, liver, and ileum pathology and gut microbiota, and used next generation sequencing and multivariate analysis to evaluate the structural changes of gut microbiota in a NAFLD rat model before and after CUR and MET intervention. It was found that both CUR and MET attenuated hepatic ectopic fat deposition, alleviated inflammatory factors, and improved intestinal barrier integrity in HFD-fed rats. More importantly, CUR and MET reduced the Firmicutes/Bacteroidetes ratio and reverted the composition of the HFD-disrupted gut microbiota. Both CUR and MET treatments effectively modified the gut microbiome, enriched the abundance of beneficial bacteria and reduced opportunistic pathogens in obese rats. The abundance of Butyricicoccus was increased while the abundance of Dorea was decreased in HFD + CUR group. Besides, some beneficial bacteria such as Prevotella were increased in MET-treated animals. Spearman's correlation analysis showed that Helicobacter, Akkermansia, Desulfovibrio, Romboutsia, Corynebacterium, Lactobacillus, Ruminococcaceae_unclassified, Lachnospiraceae_unclassified, and Clostridiales_unclassified showed significantly positive correlations with TG, TC, LDL-C, GLU, IL-6, IL-1 beta, and TNF-alpha, and negative correlations with HDL-C (both p < 0.05). However, Prevotella and Stomatobaculum showed an opposite trend. In summary, CUR and MET showed similar effects in alleviating hepatic steatosis, improving intestinal barrier integrity and modulating gut microbiota in HFD-induced obesity rats, and therefore may prove to be a novel adjunctive therapy for NAFLD.
C1 [Li, Ruifang; Bu, Shurui] Fudan Univ, Jinshan Hosp, Dept Gastroenterol, Shanghai, Peoples R China.
   [Yao, Yurong; Bu, Shurui] Fudan Univ, Jinshan Hosp, Dept Infect, Shanghai, Peoples R China.
   [Gao, Pengfei] Fudan Univ, Jinshan Hosp, Dept Tradit Chinese Med, Shanghai, Peoples R China.
C3 Fudan University; Fudan University; Fudan University
RP Bu, SR (通讯作者)，Fudan Univ, Jinshan Hosp, Dept Gastroenterol, Shanghai, Peoples R China.; Bu, SR (通讯作者)，Fudan Univ, Jinshan Hosp, Dept Infect, Shanghai, Peoples R China.; Gao, PF (通讯作者)，Fudan Univ, Jinshan Hosp, Dept Tradit Chinese Med, Shanghai, Peoples R China.
EM gaopengfeibm@163.com; bushurui@fudan.edu.cn
FU National Natural Science Foundation of China [81473610, 81973785]
FX This work was supported by grants from the National Natural Science
   Foundation of China (Grant Nos. 81473610 and 81973785).
CR Abdou RM, 2016, DIGEST DIS SCI, V61, P1268, DOI 10.1007/s10620-016-4045-1
   Abdul-Hai A, 2015, WORLD J HEPATOL, V7, P1679, DOI 10.4254/wjh.v7.i12.1679
   Bechmann LP, 2013, HEPATOLOGY, V57, P1394, DOI 10.1002/hep.26225
   Byrne CD, 2009, CLIN SCI, V116, P539, DOI 10.1042/CS20080253
   Carrera-Quintanar L, 2018, MEDIAT INFLAMM, V2018, DOI 10.1155/2018/9734845
   Chen C, 2018, FOOD FUNCT, V9, P3732, DOI [10.1039/C7FO01346A, 10.1039/c7fo01346a]
   Cox LM, 2014, CELL, V158, P705, DOI 10.1016/j.cell.2014.05.052
   CUMMINGS JH, 1991, J APPL BACTERIOL, V70, P443, DOI 10.1111/j.1365-2672.1991.tb02739.x
   DArgenio G, 1996, GASTROENTEROLOGY, V110, P1727, DOI 10.1053/gast.1996.v110.pm8964397
   Feng WH, 2017, BBA-GEN SUBJECTS, V1861, P1801, DOI 10.1016/j.bbagen.2017.03.017
   Ferguson JJA, 2018, METABOLISM, V82, P22, DOI 10.1016/j.metabol.2017.12.009
   Fontane L, 2018, CLIN INVEST ARTERIOS, V30, P271, DOI 10.1016/j.arteri.2018.03.004
   Galvez J, 2005, MOL NUTR FOOD RES, V49, P601, DOI 10.1002/mnfr.200500013
   Granado-Serrano AB, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-38874-3
   Hu SW, 2019, MAR DRUGS, V17, DOI 10.3390/md17080455
   Jin TR, 2018, AM J PHYSIOL-ENDOC M, V314, pE201, DOI 10.1152/ajpendo.00285.2017
   Karvonen AM, 2019, INT J OBESITY, V43, P713, DOI 10.1038/s41366-018-0290-z
   Leung C, 2016, NAT REV GASTRO HEPAT, V13, P412, DOI 10.1038/nrgastro.2016.85
   Li TT, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19103075
   Lin H, 2019, J AGR FOOD CHEM, V67, P3624, DOI 10.1021/acs.jafc.9b00249
   Ma JL, 2017, NUTRIENTS, V9, DOI 10.3390/nu9101124
   Magoc T, 2011, BIOINFORMATICS, V27, P2957, DOI 10.1093/bioinformatics/btr507
   Maslowski KM, 2009, NATURE, V461, P1282, DOI 10.1038/nature08530
   Mathur R, 2015, EXPERT REV GASTROENT, V9, P1087, DOI 10.1586/17474124.2015.1051029
   Meroni M, 2019, NUTRIENTS, V11, DOI 10.3390/nu11112642
   Murphy EF, 2010, GUT, V59, P1635, DOI 10.1136/gut.2010.215665
   Neyrinck AM, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0020944
   Niu Y, 2019, BRIT J NUTR, V122, P616, DOI 10.1017/S0007114519001508
   Ozkul C, 2017, TURK J GASTROENTEROL, V28, P361, DOI 10.5152/tjg.2017.17033
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Rena G, 2017, DIABETOLOGIA, V60, P1577, DOI 10.1007/s00125-017-4342-z
   Rodriguez J, 2020, GUT, V69, P1975, DOI 10.1136/gutjnl-2019-319726
   Saberi-Karimian M, 2020, COMPLEMENT THER MED, V49, DOI 10.1016/j.ctim.2020.102322
   Schloss PD, 2009, APPL ENVIRON MICROB, V75, P7537, DOI 10.1128/AEM.01541-09
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Smith PM, 2013, SCIENCE, V341, P569, DOI 10.1126/science.1241165
   Sumida Y, 2018, J GASTROENTEROL, V53, P362, DOI 10.1007/s00535-017-1415-1
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Tang WJ, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/7261619
   Van Hul M, 2018, AM J PHYSIOL-ENDOC M, V314, pE334, DOI 10.1152/ajpendo.00107.2017
   Velazquez KT, 2019, WORLD J HEPATOL, V11, P619, DOI 10.4254/wjh.v11.i8.619
   Xu J, 2015, ISME J, V9, P552, DOI 10.1038/ismej.2014.177
   Younossi Z, 2018, NAT REV GASTRO HEPAT, V15, P11, DOI 10.1038/nrgastro.2017.109
   Younossi ZM, 2016, HEPATOLOGY, V64, P73, DOI 10.1002/hep.28431
   Zeng Q, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-49462-w
   Zhang W, 2019, BIOMED PHARMACOTHER, V118, DOI 10.1016/j.biopha.2019.109131
   Zhang X, 2015, SCI REP-UK, V5, DOI 10.1038/srep14405
   Zhu LX, 2013, HEPATOLOGY, V57, P601, DOI 10.1002/hep.26093
NR 48
TC 22
Z9 23
U1 1
U2 22
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1664-302X
J9 FRONT MICROBIOL
JI Front. Microbiol.
PD JAN 14
PY 2021
VL 11
AR 555293
DI 10.3389/fmicb.2020.555293
PG 15
WC Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology
GA PY9EO
UT WOS:000612343500001
PM 33584555
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Zhao, HY
   Lyu, YJ
   Zhai, RQ
   Sun, GY
   Ding, XF
AF Zhao, Huayan
   Lyu, Yuanjun
   Zhai, Ruiqing
   Sun, Guiying
   Ding, Xianfei
TI Metformin Mitigates Sepsis-Related Neuroinflammation via Modulating Gut
   Microbiota and Metabolites
SO FRONTIERS IN IMMUNOLOGY
LA English
DT Article
DE sepsis-related neurodamage; metformin; gut microbiota; metabolites; CLP
ID CHAIN FATTY-ACIDS; ENCEPHALOPATHY; MICROGLIA; MICE
AB Gut microbiota affects the functions of brains. However, its mechanism in sepsis remains unclear. This study evaluated the effect of metformin on ameliorating sepsis-related neurodamage by regulating gut microbiota and metabolites in septic rats. Cecal ligation and puncture (CLP) was used to establish the sepsis-related neurodamage animal models. Metformin therapy by gavage at 1 h after CLP administration was followed by fecal microbiota transplantation (FMT) to ensure the efficacy and safety of metformin on the sepsis-related neurodamage by regulating gut microbiota. The gut microbiota and metabolites were conducted by 16S rRNA sequencing and liquid chromatography-tandem mass spectrometry metabolomic analysis. The brain tissue inflammation response was analyzed by histopathology and reverse transcription-polymerase chain reaction (RT-PCR). This study reported brain inflammatory response, hemorrhage in sepsis-related neurodamage rats compared with the control group (C group). Surprisingly, the abundance of gut microbiota slightly increased in sepsis-related neurodamage rats than C group. The ratio of Firmicutes/Bacteroidetes was significantly increased in the CLP group than the C group. However, no difference was observed between the CLP and the metformin-treated rats (MET group). Interestingly, the abundance of Escherichia_Shigella increased in the MET group than the C and CLP groups, while Lactobacillaceae abundance decreased. Furthermore, Prevotella_9, Muribaculaceae, and Alloprevotella related to short-chain fatty acids production increased in the sepsis-related neurodamage of metformin-treated rats. Additionally, Prevotella_9 and Muribaculaceae correlated positively to 29 metabolites that might affect the inflammatory factors in the brain. The FMT assay showed that metformin improved sepsis-related neurodamage by regulating the gut microbiota and metabolites in septic rats. The findings suggest that metformin improves the sepsis-related neurodamage through modulating the gut microbiota and metabolites in septic rats, which may be an effective therapy for patients with sepsis-related neurodamage.
C1 [Zhao, Huayan] First Affiliated Hosp Zhengzhou Univ, Dept Crit Care Med, Affiliated Hosp 1, Zhengzhou, Peoples R China.
   [Lyu, Yuanjun] Zhengzhou Univ, Dept Resp, Affiliated Hosp 1, Zhengzhou, Peoples R China.
   [Zhai, Ruiqing] Harbin Med Univ, Coll Bioinformat Sci & Technol, Harbin, Peoples R China.
   [Sun, Guiying] Zhengzhou Univ, Coll Publ Hlth, Epidemiol & Stat, Zhengzhou, Peoples R China.
   [Ding, Xianfei] Zhengzhou Univ, Gen Intens Care Unit, Affiliated Hosp 1, Zhengzhou, Peoples R China.
C3 Zhengzhou University; Harbin Medical University; Zhengzhou University;
   Zhengzhou University
RP Ding, XF (通讯作者)，Zhengzhou Univ, Gen Intens Care Unit, Affiliated Hosp 1, Zhengzhou, Peoples R China.
EM dingxianfei2009@163.com
FU youth talent promotion project in Henan Province [2021HYTP053]; Henan
   Medical Science and Technology Breakthrough Plan [LHGJ20210299]
FX This study was supported by the 2021 youth talent promotion project in
   Henan Province (Grant No. 2021HYTP053), the 2021 joint construction
   project of Henan Medical Science and Technology Breakthrough Plan (Grant
   No. LHGJ20210299).
CR Ahmadi S, 2020, J GERONTOL A-BIOL, V75, pE9, DOI 10.1093/gerona/glaa056
   Bryrup T, 2019, DIABETOLOGIA, V62, P1024, DOI 10.1007/s00125-019-4848-7
   Buchman TG, 2020, CRIT CARE MED, V48, P276, DOI 10.1097/CCM.0000000000004224
   Buse JB, 2016, DIABETES CARE, V39, P198, DOI 10.2337/dc15-0488
   Cabreiro F, 2013, CELL, V153, P228, DOI 10.1016/j.cell.2013.02.035
   Chen YX, 2019, ADV EXP MED BIOL, V1128, P103, DOI 10.1007/978-981-13-3540-2_6
   Chu C, 2019, NATURE, V574, P543, DOI 10.1038/s41586-019-1644-y
   Cornick S, 2015, TISSUE BARRIERS, V3, DOI 10.4161/21688370.2014.982426
   Dal-Pizzol F, 2014, REV BRAS PSIQUIATR, V36, P251, DOI 10.1590/1516-4446-2013-1233
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   DeMerle KM, 2021, CRIT CARE MED, V49, P748, DOI 10.1097/CCM.0000000000004842
   Douglas GM, 2020, NAT BIOTECHNOL, V38, P685, DOI 10.1038/s41587-020-0548-6
   Elbere I, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0204317
   Erny D, 2015, NAT NEUROSCI, V18, P965, DOI 10.1038/nn.4030
   Fajgenbaum DC, 2020, NEW ENGL J MED, V383, P2255, DOI 10.1056/NEJMra2026131
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Gong SH, 2019, HEPATOLOGY, V69, P1751, DOI 10.1002/hep.30361
   Gregory JC, 2015, J BIOL CHEM, V290, P5647, DOI 10.1074/jbc.M114.618249
   Hernandez-Alvarez D, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/3428543
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kelly CJ, 2015, CELL HOST MICROBE, V17, P662, DOI 10.1016/j.chom.2015.03.005
   Koh A, 2016, CELL, V165, P1332, DOI 10.1016/j.cell.2016.05.041
   Kong C, 2019, NUTRITION, V60, P175, DOI 10.1016/j.nut.2018.10.002
   Liu JM, 2020, J AGR FOOD CHEM, V68, P14874, DOI 10.1021/acs.jafc.0c06332
   Michels M, 2017, J NEUROIMMUNOL, V303, P90, DOI 10.1016/j.jneuroim.2016.12.015
   Moiseeva O, 2013, AGING CELL, V12, P489, DOI 10.1111/acel.12075
   Piazza O, 2007, BRIT J ANAESTH, V99, P518, DOI 10.1093/bja/aem201
   Rhee SI, 2014, INTEST RES, V12, P90, DOI 10.5217/ir.2014.12.2.90
   Santos NN, 2018, J NEUROIMMUNOL, V324, P143, DOI 10.1016/j.jneuroim.2018.08.013
   Song YM, 2015, AUTOPHAGY, V11, P46, DOI 10.4161/15548627.2014.984271
   Sonneville R, 2017, INTENS CARE MED, V43, P1075, DOI 10.1007/s00134-017-4807-z
   Stewart CJ, 2017, MICROBIOME, V5, DOI 10.1186/s40168-017-0295-1
   Sun JY, 2020, STEM CELL RES THER, V11, DOI 10.1186/s13287-020-01902-5
   Taccone FS, 2010, NEUROCRIT CARE, V12, P35, DOI 10.1007/s12028-009-9289-6
   Wang ZN, 2011, NATURE, V472, P57, DOI 10.1038/nature09922
   Whang A, 2019, EBIOMEDICINE, V39, P591, DOI 10.1016/j.ebiom.2018.11.046
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Zhang X, 2015, SCI REP-UK, V5, DOI 10.1038/srep14405
   Zhou D, 2017, WORLD J GASTROENTERO, V23, P60, DOI 10.3748/wjg.v23.i1.60
   Ziaja M, 2013, CURR NEUROL NEUROSCI, V13, DOI 10.1007/s11910-013-0383-y
   Zrzavy T, 2019, NEUROPATH APPL NEURO, V45, P278, DOI 10.1111/nan.12502
NR 41
TC 7
Z9 7
U1 5
U2 12
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-3224
J9 FRONT IMMUNOL
JI Front. Immunol.
PD APR 29
PY 2022
VL 13
AR 797312
DI 10.3389/fimmu.2022.797312
PG 12
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA 1H2PV
UT WOS:000796389100001
PM 35572534
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Shi, ZJ
   Lei, HH
   Chen, G
   Yuan, PH
   Cao, Z
   Ser, HL
   Zhu, XH
   Wu, F
   Liu, CX
   Dong, MY
   Song, YC
   Guo, YY
   Chen, C
   Hu, KX
   Zhu, YF
   Zeng, XA
   Zhou, JL
   Lu, YJ
   Patterson, AD
   Zhang, LM
AF Shi, Zunji
   Lei, Hehua
   Chen, Gui
   Yuan, Peihong
   Cao, Zheng
   Ser, Hooi-Leng
   Zhu, Xuehang
   Wu, Fang
   Liu, Caixiang
   Dong, Manyuan
   Song, Yuchen
   Guo, Yangyang
   Chen, Chuan
   Hu, Kexin
   Zhu, Yifan
   Zeng, Xin-an
   Zhou, Jinlin
   Lu, Yujing
   Patterson, Andrew D.
   Zhang, Limin
TI Impaired Intestinal Akkermansia muciniphila and Aryl Hydrocarbon
   Receptor Ligands Contribute to Nonalcoholic Fatty Liver Disease in Mice
SO MSYSTEMS
LA English
DT Article
DE microbiome; gut-liver axis; Akkermansia muciniphila; AHR ligands
ID HUMAN GUT MICROBIOME; NEOHESPERIDIN DIHYDROCHALCONE; ARTIFICIAL
   SWEETENERS; GLUCOSE-INTOLERANCE; METABOLISM; TRYPTOPHAN; INFLAMMATION;
   ACTIVATION; METFORMIN; ASSOCIATION
AB Noncaloric artificial sweeteners (NAS) are extensively introduced into commonly consumed drinks and foods worldwide. However, data on the health effects of NAS consumption remain elusive. Saccharin and sucralose have been shown to pass through the human gastrointestinal tract without undergoing absorption and metabolism and directly encounter the gut microbiota community. Here, we aimed to identify a novel mechanism linking intestinal Akkermansia muciniphila and the aryl hydrocarbon receptor (AHR) to saccharin/sucralose-induced nonalcoholic fatty liver disease (NAFLD) in mice. Saccharin/sucralose consumption altered the gut microbial community structure, with significant depletion of A. muciniphila abundance in the cecal contents of mice, resulting in disruption of intestinal permeability and a high level of serum lipopolysaccharide, which likely contributed to systemic inflammation and caused NAFLD in mice. Saccharin/sucralose also markedly decreased microbiota-derived AHR ligands and colonic AHR expression, which are closely associated with many metabolic syndromes. Metformin or fructo-oligosaccharide supplementation significantly restored A. muciniphila and AHR ligands in sucralose-consuming mice, consequently ameliorating NAFLD.
   IMPORTANCE Our findings indicate that the gut-liver signaling axis contributes to saccharin/sucralose consumption-induced NAFLD. Supplementation with metformin or fructo-oligosaccharide is a potential therapeutic strategy for NAFLD treatment. In addition, we also developed a new nutritional strategy by using a natural sweetener (neohesperidin dihydrochalcone (NHDC)) as a substitute for NAS and free sugars.
C1 [Shi, Zunji; Lei, Hehua; Chen, Gui; Yuan, Peihong; Cao, Zheng; Zhu, Xuehang; Wu, Fang; Liu, Caixiang; Dong, Manyuan; Song, Yuchen; Guo, Yangyang; Chen, Chuan; Hu, Kexin; Zhu, Yifan; Zhang, Limin] Chinese Acad Sci, Key Lab Magnet Resonance Biol Syst, State Key Lab Magnet Resonance & Atom & Mol Phys, Natl Ctr Magnet Resonance Wuhan,Innovat Acad Prec, Wuhan, Peoples R China.
   [Shi, Zunji; Zeng, Xin-an] South China Univ Technol, Sch Food Sci & Engn, Guangzhou, Peoples R China.
   [Ser, Hooi-Leng; Zhou, Jinlin] Guangdong Univ Technol, Sch Biomed & Pharmaceut Sci, Guangzhou, Peoples R China.
   [Chen, Gui; Cao, Zheng; Zhu, Xuehang; Wu, Fang; Dong, Manyuan; Song, Yuchen; Guo, Yangyang; Chen, Chuan; Hu, Kexin] Univ Chinese Acad Sci, Beijing, Peoples R China.
   [Zhou, Jinlin; Lu, Yujing; Zhang, Limin] Engn Res Acad High Value Utilizat Green Plants, Meizhou, Peoples R China.
   [Patterson, Andrew D.] Penn State Univ, Dept Vet & Biomed Sci, Ctr Mol Toxicol & Carcinogenesis, University Pk, PA 16802 USA.
   [Zhang, Limin] Wuhan Natl Lab Optoelect, Wuhan, Peoples R China.
C3 Chinese Academy of Sciences; South China University of Technology;
   Guangdong University of Technology; Chinese Academy of Sciences;
   University of Chinese Academy of Sciences, CAS; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); Pennsylvania State
   University; Pennsylvania State University - University Park; Huazhong
   University of Science & Technology
RP Zhang, LM (通讯作者)，Chinese Acad Sci, Key Lab Magnet Resonance Biol Syst, State Key Lab Magnet Resonance & Atom & Mol Phys, Natl Ctr Magnet Resonance Wuhan,Innovat Acad Prec, Wuhan, Peoples R China.; Zhang, LM (通讯作者)，Engn Res Acad High Value Utilizat Green Plants, Meizhou, Peoples R China.; Zhang, LM (通讯作者)，Wuhan Natl Lab Optoelect, Wuhan, Peoples R China.
EM zhanglm@wipm.ac.cn
RI Ser, Hooi-Leng/AGE-1386-2022
OI Ser, Hooi-Leng/0000-0003-3815-7436; Cao, Zheng/0000-0002-0670-0484; Shi,
   Zunji/0000-0002-1276-6762
FU National Key Research and Development Project [2018YFE0110800]; Foshan
   Core Technology Tackling Key Project [1920001000262]; China Postdoctoral
   Science Foundation [2019M662893]; National Natural Science Foundation of
   China [21635006]
FX This work was financially supported by the National Key Research and
   Development Project (grant 2018YFE0110800), the Foshan Core Technology
   Tackling Key Project (grant 1920001000262), the China Postdoctoral
   Science Foundation (grant 2019M662893), and the National Natural Science
   Foundation of China (grant 21635006).
CR Aguilar F, 2010, EFSA J, V8, DOI 10.2903/j.efsa.2010.1537
   Agus A, 2018, CELL HOST MICROBE, V23, P716, DOI 10.1016/j.chom.2018.05.003
   Alvarado DM, 2019, GASTROENTEROLOGY, V157, P1093, DOI 10.1053/j.gastro.2019.07.013
   Aoki R, 2018, J IMMUNOL, V201, P3683, DOI 10.4049/jimmunol.1701734
   Auchtung JM, 2020, ACS INFECT DIS
   Bian XM, 2017, FOOD CHEM TOXICOL, V107, P530, DOI 10.1016/j.fct.2017.04.045
   Bian XM, 2017, FRONT PHYSIOL, V8, DOI 10.3389/fphys.2017.00487
   BYARD JL, 1973, FOOD COSMET TOXICOL, V11, P391, DOI 10.1016/0015-6264(73)90005-9
   Carocho M, 2017, FOOD CHEM TOXICOL, V107, P302, DOI 10.1016/j.fct.2017.06.046
   Demehri FR, 2016, J PEDIATR SURG, V51, P81, DOI 10.1016/j.jpedsurg.2015.10.012
   Derrien M, 2008, APPL ENVIRON MICROB, V74, P1646, DOI 10.1128/AEM.01226-07
   Desai MS, 2016, CELL, V167, P1339, DOI 10.1016/j.cell.2016.10.043
   Donnelly LA, 2006, DIABETIC MED, V23, P128, DOI 10.1111/j.1464-5491.2005.01755.x
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Everard A, 2011, DIABETES, V60, P2775, DOI 10.2337/db11-0227
   Ezzaidi N, 2019, CANCER LETT, V459, P186, DOI 10.1016/j.canlet.2019.114425
   Fuertig R, 2016, BIOANALYSIS, V8, P1903, DOI 10.4155/bio-2016-0111
   Gardner C, 2012, DIABETES CARE, V35, P1798, DOI 10.2337/dc12-9002
   Goettel JA, 2016, CELL REP, V17, P1318, DOI 10.1016/j.celrep.2016.09.082
   Grander C, 2018, GUT, V67, P892, DOI 10.1136/gutjnl-2016-313432
   Hansen CHF, 2012, DIABETOLOGIA, V55, P2285, DOI 10.1007/s00125-012-2564-7
   Hao SJ, 2020, FRONT MICROBIOL, V11, DOI 10.3389/fmicb.2020.01097
   Hostalek U, 2015, DRUGS, V75, P1071, DOI 10.1007/s40265-015-0416-8
   Ruiz-Ojeda FJ, 2019, ADV NUTR, V10, pS31, DOI 10.1093/advances/nmy037
   Kleessen B, 2003, BRIT J NUTR, V89, P597, DOI 10.1079/BJN2002827
   Korecka A, 2016, NPJ BIOFILMS MICROBI, V2, DOI 10.1038/npjbiofilms.2016.14
   Lamas B, 2018, MUCOSAL IMMUNOL, V11, P1024, DOI 10.1038/s41385-018-0019-2
   Lamas B, 2016, NAT MED, V22, P598, DOI 10.1038/nm.4102
   Larigot Lucie, 2018, Biochim Open, V7, P1, DOI 10.1016/j.biopen.2018.05.001
   Liu CW, 2019, J PROTEOMICS, V196, P1, DOI 10.1016/j.jprot.2019.01.011
   Luck H, 2015, CELL METAB, V21, P527, DOI 10.1016/j.cmet.2015.03.001
   Monteleone I, 2012, CURR OPIN GASTROEN, V28, P310, DOI 10.1097/MOG.0b013e328352ad69
   Monteleone I, 2011, GASTROENTEROLOGY, V141, P237, DOI 10.1053/j.gastro.2011.04.007
   Mouzaki M, 2013, HEPATOLOGY, V58, P120, DOI 10.1002/hep.26319
   Murray Iain A., 2017, Current Opinion in Toxicology, V2, P15, DOI 10.1016/j.cotox.2017.01.003
   Murray IA, 2014, NAT REV CANCER, V14, P801, DOI 10.1038/nrc3846
   Natividad JM, 2018, CELL METAB, V28, P737, DOI 10.1016/j.cmet.2018.07.001
   Png CW, 2010, AM J GASTROENTEROL, V105, P2420, DOI 10.1038/ajg.2010.281
   Prendergast GC, 2011, CURR MED CHEM, V18, P2257, DOI 0929-8673/11 $58.00+.00
   Qin N, 2014, NATURE, V513, P59, DOI 10.1038/nature13568
   Rivero-Gutierrez B, 2017, MOL NUTR FOOD RES, V61, DOI 10.1002/mnfr.201600622
   Roberts A, 2000, FOOD CHEM TOXICOL, V38, pS31, DOI 10.1016/S0278-6915(00)00026-0
   Routy B, 2018, SCIENCE, V359, P91, DOI 10.1126/science.aan3706
   Santacruz A, 2010, BRIT J NUTR, V104, P83, DOI 10.1017/S0007114510000176
   Schirmer M, 2016, CELL, V167, P1125, DOI 10.1016/j.cell.2016.10.020
   Shi Q, 2015, INT IMMUNOPHARMACOL, V29, P722, DOI 10.1016/j.intimp.2015.09.003
   Shin NR, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.02271
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Spencer M, 2016, J NEUROGASTROENTEROL, V22, P168, DOI 10.5056/jnm15206
   Su CY, 2015, J AGR FOOD CHEM, V63, P5468, DOI 10.1021/acs.jafc.5b01750
   Suez Jotham, 2014, Nature, V514, P181, DOI 10.1038/nature13793
   Vanni E, 2009, HEPATOLOGY, V49, P1790, DOI 10.1002/hep.23036
   Xu ZD, 2010, LIPIDS, V45, P199, DOI 10.1007/s11745-009-3382-7
   Yerevanian A, 2019, CURR OBES REP, V8, P156, DOI 10.1007/s13679-019-00335-3
   Zelante T, 2013, IMMUNITY, V39, P372, DOI 10.1016/j.immuni.2013.08.003
   Zhang LM, 2015, ENVIRON SCI TECHNOL, V49, P8067, DOI 10.1021/acs.est.5b01389
   Zhang LM, 2015, ENVIRON HEALTH PERSP, V123, P679, DOI 10.1289/ehp.1409055
   Zhou KQ, 2017, J FUNCT FOODS, V33, P194, DOI 10.1016/j.jff.2017.03.045
NR 58
TC 17
Z9 18
U1 4
U2 53
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 2379-5077
J9 MSYSTEMS
JI mSystems
PD JAN-FEB
PY 2021
VL 6
IS 1
AR e00985-20
DI 10.1128/mSystems.00985-20
PG 17
WC Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology
GA RY1QE
UT WOS:000647691000035
PM 33622853
OA Green Published
DA 2023-06-08
ER

PT J
AU Silamikele, L
   Silamikelis, I
   Ustinova, M
   Kalnina, Z
   Elbere, I
   Petrovska, R
   Kalnina, I
   Klovins, J
AF Silamikele, Laila
   Silamikelis, Ivars
   Ustinova, Monta
   Kalnina, Zane
   Elbere, Ilze
   Petrovska, Ramona
   Kalnina, Ineta
   Klovins, Janis
TI Metformin Strongly Affects Gut Microbiome Composition in High-Fat
   Diet-Induced Type 2 Diabetes Mouse Model of Both Sexes
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE metformin; microbiome; metagenome; high-fat diet; C57BL; 6N
AB Effects of metformin, the first-line drug for type 2 diabetes therapy, on gut microbiome composition in type 2 diabetes have been described in various studies both in human subjects and animals. However, the details of the molecular mechanisms of metformin action have not been fully understood. Moreover, there is a significant lack of information on how metformin affects gut microbiome composition in female mouse models, depending on sex and metabolic status in well controlled experimental setting. Our study aimed to examine metformin-induced alterations in gut microbiome diversity, composition, and functional implications of high-fat diet-induced type 2 diabetes mouse model, using, for the first time in mice study, the shotgun metagenomic sequencing that allows estimation of microorganisms at species level. We also employed a randomized block, factorial study design, and including 24 experimental units allocated to 8 treatment groups to systematically evaluate the effect of sex and metabolic status on metformin interaction with microbiome. We used DNA obtained from fecal samples representing gut microbiome before and after ten weeks-long metformin treatment. We identified 100 metformin-related differentially abundant species in high-fat diet-fed mice before and after the treatment, with most of the species relative abundances increased. In contrast, no significant changes were observed in control diet-fed mice. Functional analysis targeted to carbohydrate, lipid, and amino acid metabolism pathways revealed 14 significantly altered hierarchies. We also observed sex-specific differences in response to metformin treatment. Males experienced more pronounced changes in metabolic markers, while in females the extent of changes in gut microbiome representatives was more marked, indicated by 53 differentially abundant species with more remarkable Log fold changes compared to the combined-sex analysis. The same pattern manifested regarding the functional analysis, where we discovered 5 significantly affected hierarchies in female groups but not in males. Our results suggest that both sexes of animals should be included in future studies focusing on metformin effects on the gut microbiome.
C1 [Silamikele, Laila; Silamikelis, Ivars; Ustinova, Monta; Kalnina, Zane; Elbere, Ilze; Petrovska, Ramona; Kalnina, Ineta; Klovins, Janis] Latvian Biomed Res & Study Ctr, Riga, Latvia.
C3 Latvian Biomedical Research & Study Centre
RP Klovins, J (通讯作者)，Latvian Biomed Res & Study Ctr, Riga, Latvia.
EM klovins@biomed.lu.lv
RI Kalnina, Zane/AAH-9884-2021
OI Kalnina, Zane/0000-0001-9002-3131; Klovins, Janis/0000-0001-8362-5505;
   Elbere, Ilze/0000-0003-4381-885X; Silamikelis,
   Ivars/0000-0002-7932-1047; Silamikele, Laila/0000-0003-2550-0434
FU European Regional Development Fund (ERDF) [1.1.1.1/16/A/091]
FX This work was supported by European Regional Development Fund (ERDF),
   Measure 1.1.1.1 "Support for applied research" project "Investigation of
   interplay between multiple determinants influencing response to
   metformin: search for reliable predictors for efficacy of type 2diabetes
   therapy"(GrantNo. 1.1.1.1/16/A/091).
CR Acharya KD, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-56723-1
   Aitchison J., 1986, STAT ANAL COMPOSITIO, DOI DOI 10.1007/978-94-009-4109-0
   Andrews S., 2010, FASTQC QUALITY CONTR, DOI DOI 10.1186/1472-6963-10-122
   Bassanini G, 2019, FRONT CELL INFECT MI, V9, DOI 10.3389/fcimb.2019.00101
   Bauer PV, 2018, CELL METAB, V27, P101, DOI 10.1016/j.cmet.2017.09.019
   Bolger AM, 2014, BIOINFORMATICS, V30, P2114, DOI 10.1093/bioinformatics/btu170
   Braune A, 2016, GUT MICROBES, V7, P216, DOI 10.1080/19490976.2016.1158395
   Bryrup T, 2019, DIABETOLOGIA, V62, P1024, DOI 10.1007/s00125-019-4848-7
   Clavel T, 2014, GUT MICROBES, V5, P544, DOI 10.4161/gmic.29331
   Dalby MJ, 2017, CELL REP, V21, P1521, DOI 10.1016/j.celrep.2017.10.056
   Davies MJ, 2018, DIABETOLOGIA, V61, P2461, DOI [10.1007/s00125-018-4729-5, 10.2337/dci18-0033]
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Del Rio D, 2013, ANTIOXID REDOX SIGN, V18, P1818, DOI 10.1089/ars.2012.4581
   Dujic T, 2016, DIABETIC MED, V33, P511, DOI 10.1111/dme.13040
   Elbere I, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0204317
   Festing MFW., 2016, LAB ANIMAL HDB, V2nd, P144
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Gao XY, 2019, PEERJ, V7, DOI 10.7717/peerj.7117
   Geurts L, 2011, FRONT MICROBIOL, V2, DOI 10.3389/fmicb.2011.00149
   Graham GG, 2011, CLIN PHARMACOKINET, V50, P81, DOI 10.2165/11534750-000000000-00000
   Gupta A, 2019, MSYSTEMS, V4, DOI 10.1128/mSystems.00438-19
   He L, 2015, CELL METAB, V21, P159, DOI 10.1016/j.cmet.2015.01.003
   Higurashi T, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00622
   Ji SQ, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00704
   Kaliannan K, 2018, MICROBIOME, V6, DOI 10.1186/s40168-018-0587-0
   Kant R, 2015, GENOME ANNOUNCEMENTS, V3, DOI 10.1128/genomeA.00224-15
   Kinaan M, 2015, MED PRIN PRACT, V24, P401, DOI 10.1159/000381643
   Klaring K, 2013, INT J SYST EVOL MICR, V63, P4606, DOI 10.1099/ijs.0.051441-0
   La Rosa SL, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-08812-y
   Lee H, 2018, GUT MICROBES, V9, P155, DOI 10.1080/19490976.2017.1405209
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Lee SY, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0135858
   Li Q, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-62224-3
   Li X, 2017, FRONT IMMUNOL, V8, DOI 10.3389/fimmu.2017.01882
   Liang JQ, 2020, GUT, V69, P1248, DOI 10.1136/gutjnl-2019-318532
   Lidster K, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-51674-z
   Logan JMJ, 2000, INT J SYST EVOL MICR, V50, P865, DOI 10.1099/00207713-50-2-865
   Loubinoux J, 2002, FEMS MICROBIOL ECOL, V40, P107, DOI 10.1111/j.1574-6941.2002.tb00942.x
   Lu J, 2017, PEERJ COMPUT SCI, DOI 10.7717/peerj-cs.104
   Martin M., 2011, EMBNET J, V17, P10, DOI DOI 10.14806/EJ.17.1.200
   Martin-Fernandez JA, 2015, STAT MODEL, V15, DOI 10.1177/1471082X14535524
   McCreight LJ, 2016, DIABETOLOGIA, V59, P426, DOI 10.1007/s00125-015-3844-9
   McKnite AM, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0039191
   Mende DR, 2020, NUCLEIC ACIDS RES, V48, pD621, DOI 10.1093/nar/gkz1002
   Napolitano A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100778
   Oliphant K, 2019, MICROBIOME, V7, DOI 10.1186/s40168-019-0704-8
   Org E, 2016, GUT MICROBES, V7, P313, DOI 10.1080/19490976.2016.1203502
   Palacios T, 2020, NUTRIENTS, V12, DOI 10.3390/nu12072041
   Prattichizzo F, 2018, AGEING RES REV, V48, P87, DOI 10.1016/j.arr.2018.10.003
   Ritchie ME, 2015, NUCLEIC ACIDS RES, V43, DOI 10.1093/nar/gkv007
   Riviere A, 2016, FRONT MICROBIOL, V7, DOI 10.3389/fmicb.2016.00979
   Robinson MD, 2010, BIOINFORMATICS, V26, P139, DOI 10.1093/bioinformatics/btp616
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Silamiele L., 2020, METFORMIN STRONGLY A, DOI [10.1101/2020.10.30.362095, DOI 10.1101/2020.10.30.362095]
   Steer T, 2001, SYST APPL MICROBIOL, V24, P353, DOI 10.1078/0723-2020-00044
   Stepensky D, 2002, DRUG METAB DISPOS, V30, P861, DOI 10.1124/dmd.30.8.861
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Ustinova M, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0237400
   Wang JJ, 2019, FRONT MICROBIOL, V10, DOI 10.3389/fmicb.2019.00887
   WILKINS TD, 1974, INT J SYST BACTERIOL, V24, P408, DOI 10.1099/00207713-24-4-408
   Wood DE, 2019, GENOME BIOL, V20, DOI 10.1186/s13059-019-1891-0
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Wu TZ, 2017, EXPERT REV GASTROENT, V11, P157, DOI 10.1080/17474124.2017.1273769
   Yerevanian A, 2019, CURR OBES REP, V8, P156, DOI 10.1007/s13679-019-00335-3
   Zhang Q, 2020, DIABET METAB SYND OB, V13, P5003, DOI 10.2147/DMSO.S286430
   Zhang X, 2015, SCI REP-UK, V5, DOI 10.1038/srep14405
NR 66
TC 19
Z9 20
U1 1
U2 14
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD MAR 19
PY 2021
VL 12
AR 626359
DI 10.3389/fendo.2021.626359
PG 16
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA RH1KY
UT WOS:000635987700001
PM 33815284
OA Green Published, Green Submitted, gold
DA 2023-06-08
ER

PT J
AU Le Bastard, Q
   Berthelot, L
   Soulillou, JP
   Montassier, E
AF Le Bastard, Quentin
   Berthelot, Laureline
   Soulillou, Jean-Paul
   Montassier, Emmanuel
TI Impact of non-antibiotic drugs on the human intestinal microbiome
SO EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
LA English
DT Review
DE PPI; metformin; statin; nsaid; gut microbiota; microbiome
ID PROTON-PUMP INHIBITORS; NONSTEROIDAL ANTIINFLAMMATORY DRUG; GUT
   MICROBIOTA; RISK-FACTORS; BILE-ACID; METFORMIN; OMEPRAZOLE;
   ROSUVASTATIN; ATORVASTATIN; THERAPY
AB Introduction The gut microbiota is composed of trillions of microbial cells and viruses that interact with hosts. The composition of the gut microbiota is influenced by several factors including age, diet, diseases, or medications. The impact of drugs on the microbiota is not limited to antibiotics and many non-antibiotic molecules significantly alter the composition of the intestinal microbiota. Areas covered This review focuses on the impact of four of the most widely prescribed non-antibiotic drugs in the world: Proton-pump inhibitors, metformin, statins, and non-steroidal anti-inflammatory. We conducted a systematic review by searching online databases including Medline, Web of science, and Scopus for indexed articles published in English until February 2021. We included studies assessing the intestinal microbiome alterations associated with proton pump inhibitors (PPIs), metformin, statins, and nonsteroidal anti-inflammatory drugs (NSAIDs). Only studies using culture-independent molecular techniques were included. Expert opinion The taxonomical signature associated with non-antibiotic drugs are not yet fully described, especially in the field of metabolomic. The identification of taxonomic profiles associated a specific molecule provides information on its mechanism of action through interaction with the intestinal microbiota. Many side effects could be related to the dysbiosis induced by these molecules.
C1 [Le Bastard, Quentin; Montassier, Emmanuel] Univ Nantes, Microbiota Hosts Antibiot & Bacterial Resistances, Nantes, France.
   [Le Bastard, Quentin; Montassier, Emmanuel] CHU Nantes, Serv Urgences, Nantes, France.
   [Berthelot, Laureline; Soulillou, Jean-Paul] Univ Nantes, Ctr Rech Transplantat & Immunol UMR 1064, INSERM, Nantes, France.
   [Berthelot, Laureline; Soulillou, Jean-Paul] CHU Nantes, Inst Transplantat Urol Nephrol ITUN, Nantes, France.
C3 Nantes Universite; Nantes Universite; CHU de Nantes; Institut National
   de la Sante et de la Recherche Medicale (Inserm); Nantes Universite;
   Nantes Universite; CHU de Nantes
RP Montassier, E (通讯作者)，Univ Nantes, Microbiota Hosts Antibiot & Bacterial Resistances, Nantes, France.; Montassier, E (通讯作者)，CHU Nantes, Serv Urgences, Nantes, France.
EM emmanuel.montassier@chu-nantes.fr
RI Berthelot, Laureline/T-1096-2017; Berthelot, Laureline/AAE-6262-2022
OI Berthelot, Laureline/0000-0002-9306-9247; Berthelot,
   Laureline/0000-0002-9306-9247
CR [Anonymous], 2021, Eur Heart J, V42, P2298, DOI 10.1093/eurheartj/ehab285
   [Anonymous], MED USE SPENDING US
   [Anonymous], EUROPEAN HLTH INTERV
   Bajaj JS, 2014, AM J PHYSIOL-GASTR L, V307, pG951, DOI 10.1152/ajpgi.00268.2014
   Bedarf JR, 2017, GENOME MED, V9, DOI 10.1186/s13073-017-0428-y
   Castro CAB, 2017, COLECC JUS-PENAL, V14, P7
   Bokulich NA, 2016, CLIN MICROBIOL INFEC, V22, P464, DOI 10.1016/j.cmi.2016.01.013
   BONORA E, 1984, CURR MED RES OPIN, V9, P47, DOI 10.1185/03007998409109558
   Bouwknegt M, 2014, EUROSURVEILLANCE, V19, P21, DOI 10.2807/1560-7917.ES2014.19.32.20873
   Bryrup T, 2019, DIABETOLOGIA, V62, P1024, DOI 10.1007/s00125-019-4848-7
   Chen JJ, 2012, BRIT J NUTR, V107, P1429, DOI 10.1017/S0007114511004491
   Clemente JC, 2012, CELL, V148, P1258, DOI 10.1016/j.cell.2012.01.035
   Clooney AG, 2016, ALIMENT PHARM THER, V43, P974, DOI 10.1111/apt.13568
   Collins R, 2016, LANCET, V388, P2532, DOI 10.1016/S0140-6736(16)31357-5
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Donskey CJ, 2000, NEW ENGL J MED, V343, P1925, DOI 10.1056/NEJM200012283432604
   Elbere I, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0241338
   Elbere I, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0204317
   Endo A, 2008, NAT MED, V14, P1050, DOI 10.1038/nm1008-1050
   Endo H, 2014, GASTROINTEST ENDOSC, V80, P826, DOI 10.1016/j.gie.2014.03.024
   Epstein M, 2006, NEW ENGL J MED, V355, P1834, DOI 10.1056/NEJMc066308
   Falony G, 2016, SCIENCE, V352, P560, DOI 10.1126/science.aad3503
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Freedberg DE, 2015, GASTROENTEROLOGY, V149, P883, DOI 10.1053/j.gastro.2015.06.043
   Fu ZD, 2014, J LIPID RES, V55, P2576, DOI 10.1194/jlr.M053124
   Garcia-Mazcorro JF, 2012, FEMS MICROBIOL ECOL, V80, P624, DOI 10.1111/j.1574-6941.2012.01331.x
   GIUGLIANO D, 1993, DIABETES CARE, V16, P1387, DOI 10.2337/diacare.16.10.1387
   Gu YY, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-01682-2
   Hojo M, 2018, DIGEST DIS SCI, V63, P2940, DOI 10.1007/s10620-018-5122-4
   Horvath A, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-48352-5
   Imhann F, 2016, GUT, V65, P740, DOI 10.1136/gutjnl-2015-310376
   Inzucchi SE, 2015, DIABETES CARE, V38, P140, DOI 10.2337/dc14-2441
   IWAHI T, 1991, ANTIMICROB AGENTS CH, V35, P490, DOI 10.1128/AAC.35.3.490
   Jackson MA, 2016, GUT, V65, P749, DOI 10.1136/gutjnl-2015-310861
   Janarthanan S, 2012, AM J GASTROENTEROL, V107, P1001, DOI 10.1038/ajg.2012.179
   Jang S, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000021488
   Jonkers D, 1996, J ANTIMICROB CHEMOTH, V37, P145, DOI 10.1093/jac/37.1.145
   Karlson B, 2016, EUR HEART J-CARD PHA, V2, P212, DOI 10.1093/ehjcvp/pvw006
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Keeney KM, 2014, ANNU REV MICROBIOL, V68, P217, DOI 10.1146/annurev-micro-091313-103456
   Kelly OB, 2015, DIGEST DIS SCI, V60, P2280, DOI 10.1007/s10620-015-3642-8
   Khan TJ, 2018, OMICS, V22, P154, DOI 10.1089/omi.2017.0130
   Kinouchi T, 1998, MICROBIOL IMMUNOL, V42, P347, DOI 10.1111/j.1348-0421.1998.tb02294.x
   Klaassen CD, 2010, PHARMACOL REV, V62, P1, DOI 10.1124/pr.109.002014
   Koo SH, 2019, SINGAP MED J, V60, P512, DOI 10.11622/smedj.2018152
   Kummen M, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-62261-y
   Lang A. J., 2016, General Technical Report - Southern Research Station, USDA Forest Service, P8
   Leonard J, 2007, AM J GASTROENTEROL, V102, P2047, DOI 10.1111/j.1572-0241.2007.01275.x
   Liang X, 2015, ELIFE, V4, DOI 10.7554/eLife.08973
   Liu YH, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.00530
   Maier L, 2018, NATURE, V555, P623, DOI 10.1038/nature25979
   Makivuokko H, 2010, BRIT J NUTR, V103, P227, DOI 10.1017/S0007114509991553
   Markovits N, 2014, J CLIN PHARMACOL, V54, P889, DOI 10.1002/jcph.316
   Massey W, 2021, ENDOCRINOLOGY, V162, DOI 10.1210/endocr/bqaa235
   Massialos E., 2005, QUALITY SAFETY HLTH, V14, P227, DOI [10.1136/qshc.2004.012070, DOI 10.1136/QSHC.2004.012070]
   Mastracci TL, 2015, SCI REP-UK, V5, DOI 10.1038/srep13269
   Melchers K, 1998, ACTA PHYSIOL SCAND, V163, P123
   Meyer-Kirchrath J, 2000, CURR MED CHEM, V7, P1121, DOI 10.2174/0929867003374219
   Moayyedi P, 2006, LANCET, V367, P2086, DOI 10.1016/S0140-6736(06)68932-0
   Nakajima H, 2020, LIFE-BASEL, V10, DOI 10.3390/life10090195
   Napolitano A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100778
   Nolan JA, 2017, AM J PHYSIOL-GASTR L, V312, pG488, DOI 10.1152/ajpgi.00149.2016
   Ogden CL., 2019, FRONT CELL INFECT MI, P8
   Park, 2020, RHEUMATOL OXF ENGL
   Pastor-Villaescusa B, 2021, BIOMED PHARMACOTHER, V134, DOI 10.1016/j.biopha.2020.111117
   Poullis A, 2003, EUR J GASTROEN HEPAT, V15, P573, DOI 10.1097/01.meg.0000059108.41030.23
   Prizment AE, 2020, ALIMENT PHARM THER, V52, P976, DOI 10.1111/apt.16013
   Pryor R, 2019, CELL, V178, P1299, DOI 10.1016/j.cell.2019.08.003
   Rainsford K. D., 2007, V42, P3
   ROBERT A, 1977, PROSTAGLANDINS, V14, P333, DOI 10.1016/0090-6980(77)90178-2
   Rogers MAM, 2016, CLIN MICROBIOL INFEC, V22, DOI 10.1016/j.cmi.2015.10.003
   Saad AZM, 2005, INT J CLIN PRACT, V59, P31, DOI 10.1111/j.1368-5031.2004.00298.x
   Seto CT, 2014, MICROBIOME, V2, DOI 10.1186/2049-2618-2-42
   Shi YC, 2019, GENOM PROTEOM BIOINF, V17, P52, DOI 10.1016/j.gpb.2018.12.004
   Shields William W, 2009, Therap Adv Gastroenterol, V2, P157, DOI 10.1177/1756283X09105462
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Statistics (US) NC for H, 2019, TABL 38 PRESCR DRUG
   Sun BQ, 2018, J MICROBIOL, V56, P886, DOI 10.1007/s12275-018-8152-x
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Tanigawa T, 2021, PLOS ONE, V16, DOI 10.1371/journal.pone.0245995
   Thompson PD, 2016, J AM COLL CARDIOL, V67, P2395, DOI 10.1016/j.jacc.2016.02.071
   Tong XL, 2018, MBIO, V9, DOI 10.1128/mBio.02392-17
   Tuteja S, 2019, CIRC-GENOM PRECIS ME, V12, P421, DOI 10.1161/CIRCGEN.119.002314
   Vesper BJ, 2009, CURR DRUG METAB, V10, P84, DOI 10.2174/138920009787048392
   Vieira-Silva S, 2020, NATURE, V581, P310, DOI 10.1038/s41586-020-2269-x
   Vila AV, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-019-14177-z
   Vincent C, 2016, MICROBIOME, V4, DOI 10.1186/s40168-016-0156-3
   Vincent C, 2013, MICROBIOME, V1, DOI 10.1186/2049-2618-1-18
   Wallace JL, 2011, GASTROENTEROLOGY, V141, P1314, DOI 10.1053/j.gastro.2011.06.075
   Washio E, 2016, CLIN GASTROENTEROL H, V14, P809, DOI 10.1016/j.cgh.2015.10.022
   Watanabe T, 2013, DIGEST LIVER DIS, V45, P390, DOI 10.1016/j.dld.2012.12.005
   Wellhoner F, 2019, SCAND J GASTROENTERO, V54, P1033, DOI 10.1080/00365521.2019.1647280
   Willems RPJ, 2020, JAMA INTERN MED, V180, P561, DOI 10.1001/jamainternmed.2020.0009
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Yamamoto K, 2019, HEPATOL INT, V13, P234, DOI 10.1007/s12072-019-09932-9
   Yang YX, 2010, GASTROENTEROLOGY, V139, P1115, DOI 10.1053/j.gastro.2010.08.023
   Yeomans ND, 1998, NEW ENGL J MED, V338, P719, DOI 10.1056/NEJM199803123381104
   Yu YH, 2012, DIGEST DIS SCI, V57, P2669, DOI 10.1007/s10620-012-2315-0
   Zhang FH, 2019, ENDOCRINE, V66, P485, DOI 10.1007/s12020-019-02041-5
   Zhang JH, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-52632-5
   Zhang X, 2015, SCI REP-UK, V5, DOI 10.1038/srep14405
   Zhernakova A, 2016, SCIENCE, V352, P565, DOI 10.1126/science.aad3369
   Zhu, 2013, PLOS ONE, V8, DOI [10.1371/annotation/8e8e95ca-1ac3-4acf-abcb-223cd11ac1c1, DOI 10.1371/ANNOTATION/8E8E95CA-1AC3-4ACF-ABCB-223CD11AC1C1]
NR 103
TC 11
Z9 11
U1 5
U2 15
PU TAYLOR & FRANCIS AS
PI OSLO
PA KARL JOHANS GATE 5, NO-0154 OSLO, NORWAY
SN 1473-7159
EI 1744-8352
J9 EXPERT REV MOL DIAGN
JI Expert Rev. Mol. Diagn.
PD SEP 2
PY 2021
VL 21
IS 9
BP 911
EP 924
DI 10.1080/14737159.2021.1952075
EA JUL 2021
PG 14
WC Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pathology
GA WA1VJ
UT WOS:000673324600001
PM 34225544
DA 2023-06-08
ER

PT J
AU Elbere, I
   Silamikelis, I
   Dindune, II
   Kalnina, I
   Ustinova, M
   Zaharenko, L
   Silamikele, L
   Rovite, V
   Gudra, D
   Konrade, I
   Sokolovska, J
   Pirags, V
   Klovins, J
AF Elbere, Ilze
   Silamikelis, Ivars
   Dindune, Ilze Izabella
   Kalnina, Ineta
   Ustinova, Monta
   Zaharenko, Linda
   Silamikele, Laila
   Rovite, Vita
   Gudra, Dita
   Konrade, Ilze
   Sokolovska, Jelizaveta
   Pirags, Valdis
   Klovins, Janis
TI Baseline gut microbiome composition predicts metformin therapy
   short-term efficacy in newly diagnosed type 2 diabetes patients
SO PLOS ONE
LA English
DT Article
ID GASTROINTESTINAL-TRACT; SUCCINATE
AB Background
   The study was conducted to investigate the effects of metformin treatment on the human gut microbiome's taxonomic and functional profile in the Latvian population, and to evaluate the correlation of these changes with therapeutic efficacy and tolerance.
   Methods
   In this longitudinal observational study, stool samples for shotgun metagenomic sequencing-based analysis were collected in two cohorts. The first cohort included 35 healthy nondiabetic individuals (metformin dose 2x850mg/day) at three time-points during metformin administration. The second cohort was composed of 50 newly-diagnosed type 2 diabetes patients (metformin dose-determined by an endocrinologist) at two concordant times. Patients were defined as Responders if their HbA1c levels during three months of metformin therapy had decreased by >= 12.6 mmol/mol (1%), while in Non-responders HbA1c were decreased by <12.6 mmol/mol (1%).
   Results
   Metformin reduced the alpha diversity of microbiota in healthy controls (p = 0.02) but not in T2D patients. At the species level, reduction in the abundance of Clostridium bartlettii and Barnesiella intestinihominis, as well as an increase in the abundance of Parabacteroides distasonis and Oscillibacter unclassified overlapped between both study groups. A large number of group-specific changes in taxonomic and functional profiles was observed. We identified an increased abundance of Prevotella copri (FDR = 0.01) in the Non-Responders subgroup, and enrichment of Enterococcus faecium, Lactococcus lactis, Odoribacter, and Dialister at baseline in the Responders group. Various taxonomic units were associated with the observed incidence of side effects in both cohorts.
   Conclusions
   Metformin effects are different in T2D patients and healthy individuals. Therapy induced changes in the composition of gut microbiome revealed possible mediators of observed short-term therapeutic effects. The baseline composition of the gut microbiome may influence metformin therapy efficacy and tolerance in T2D patients and could be used as a powerful prediction tool.
C1 [Elbere, Ilze; Silamikelis, Ivars; Dindune, Ilze Izabella; Kalnina, Ineta; Ustinova, Monta; Zaharenko, Linda; Silamikele, Laila; Rovite, Vita; Gudra, Dita; Konrade, Ilze; Pirags, Valdis; Klovins, Janis] Latvian Biomed Res & Study Ctr, Riga, Latvia.
   [Konrade, Ilze] Riga Stradins Univ, Riga, Latvia.
   [Sokolovska, Jelizaveta; Pirags, Valdis] Univ Latvia, Fac Med, Riga, Latvia.
C3 Latvian Biomedical Research & Study Centre; Riga Stradins University;
   University of Latvia
RP Klovins, J (通讯作者)，Latvian Biomed Res & Study Ctr, Riga, Latvia.
EM klovins@biomed.lu.lv
RI Klovins, Janis/C-5695-2011
OI Klovins, Janis/0000-0001-8362-5505; Sokolovska,
   Jelizaveta/0000-0003-0448-8229; Elbere, Ilze/0000-0003-4381-885X;
   Silamikelis, Ivars/0000-0002-7932-1047
FU European Regional Development Fund [1.1.1.1/16/A/091]
FX The work was supported by the European Regional Development Fund under
   the project "Investigation of interplay between multiple determinants
   influencing response to metformin: search for reliable predictors for
   efficacy of type 2 diabetes therapy" (Project No. 1.1.1.1/16/A/091,
   https://ec.europa.eu/regional_policy/en/funding/erdf).The funders had no
   role in study design, data collection and analysis, decision to publish,
   or preparation of the manuscript.
CR Arboleya S, 2016, FRONT MICROBIOL, V7, DOI 10.3389/fmicb.2016.01204
   Asquith M, 2016, CURR OPIN RHEUMATOL, V28, P405, DOI 10.1097/BOR.0000000000000299
   Brahe LK, 2015, NUTR DIABETES, V5, DOI 10.1038/nutd.2015.9
   Bryrup T, 2019, DIABETOLOGIA, V62, P1024, DOI 10.1007/s00125-019-4848-7
   Burbach K, 2016, MICROBIOLOGYOPEN, V5, P70, DOI 10.1002/mbo3.312
   Cabreiro F, 2013, CELL, V153, P228, DOI 10.1016/j.cell.2013.02.035
   Cao KAL, 2011, BMC BIOINFORMATICS, V12, DOI 10.1186/1471-2105-12-253
   CONNORS J, 2018, NUTRIENTS, V11, P1, DOI DOI 10.3390/nu11010025
   De Filippis F, 2019, CELL HOST MICROBE, V25, P444, DOI 10.1016/j.chom.2019.01.004
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   De Vadder F, 2016, CELL METAB, V24, P151, DOI 10.1016/j.cmet.2016.06.013
   Doumatey AP, 2020, FRONT CELL INFECT MI, V10, DOI 10.3389/fcimb.2020.00063
   Elbere I, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0204317
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Franzosa EA, 2018, NAT METHODS, V15, P962, DOI 10.1038/s41592-018-0176-y
   Ganesan K, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19123720
   Gerritsen J, 2014, INT J SYST EVOL MICR, V64, P1600, DOI 10.1099/ijs.0.059543-0
   Gurung M, 2020, EBIOMEDICINE, V51, DOI 10.1016/j.ebiom.2019.11.051
   Haro C, 2016, J CLIN ENDOCR METAB, V101, P232, DOI 10.1210/jc.2015-3351
   HAUPT E, 1991, DIABETES METAB, V17, P224
   Janes VA, 2020, J MICROBIOL METH, V176, DOI 10.1016/j.mimet.2020.106005
   Jones AG, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0152428
   Kahn SE, 2006, NEW ENGL J MED, V355, P2427, DOI 10.1056/NEJMoa066224
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kashi Z, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0151543
   Knowler WC, 2002, NEW ENGL J MED, V346, P393, DOI 10.1056/NEJMoa012512
   Leite AZ, 2017, FRONT IMMUNOL, V8, DOI 10.3389/fimmu.2017.01107
   Lord JM, 2003, BRIT MED J, V327, P951, DOI 10.1136/bmj.327.7421.951
   Ma W, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.01336
   Makizaki Y, 2020, BIOSCI MICROB FOOD H, V39, P145, DOI 10.12938/bmfh.2019-022
   Olgun A, 2017, MED HYPOTHESES, V106, P33, DOI [10.1016/j.mehy.2017.07.009, 10.1016]
   Palacios T, 2020, NUTRIENTS, V12, DOI 10.3390/nu12072041
   Paley S, 2017, NUCLEIC ACIDS RES, V45, P12113, DOI 10.1093/nar/gkx910
   Pedersen HK, 2016, NATURE, V535, P376, DOI 10.1038/nature18646
   Petrosino JF, 2018, GENOME MED, V10, DOI 10.1186/s13073-018-0525-6
   Porter KM, 2019, J CLIN ENDOCR METAB, V104, P4837, DOI 10.1210/jc.2018-01791
   Rashid M, 2019, PAK J MED SCI, V35, P71, DOI 10.12669/pjms.35.1.100
   Rosario D, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.00775
   Rovite V, 2018, J EPIDEMIOL
   Sherifali D, 2010, DIABETES CARE, V33, P1859, DOI 10.2337/dc09-1727
   Siljander H, 2019, EBIOMEDICINE, V46, P512, DOI 10.1016/j.ebiom.2019.06.031
   Skyler JS, 2017, DIABETES, V66, P241, DOI 10.2337/db16-0806
   Torondel B, 2016, MICROB BIOTECHNOL, V9, P209, DOI 10.1111/1751-7915.12334
   Truong DT, 2015, NAT METHODS, V12, P902, DOI 10.1038/nmeth.3589
   Wakeman M, 2020, DIABET METAB SYND OB, V13, P2093, DOI 10.2147/DMSO.S237454
   Walsh AM, 2018, MICROBIOME, V6, DOI 10.1186/s40168-018-0437-0
   Walter J, 2013, GUT MICROBES, V4, P340, DOI 10.4161/gmic.24707
   Wang K, 2019, CELL REP, V26, P222, DOI 10.1016/j.celrep.2018.12.028
   Wang Y, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0172774
   Weersma RK, 2020, GUT, V69, P1510, DOI 10.1136/gutjnl-2019-320204
   Wei SY, 2018, NUTR METAB, V15, DOI 10.1186/s12986-018-0318-3
   Wexler AG, 2017, NAT MICROBIOL, V2, DOI 10.1038/nmicrobiol.2017.26
   Whang A, 2019, EBIOMEDICINE, V39, P591, DOI 10.1016/j.ebiom.2018.11.046
   Wingfield B, 2019, IEEE ACM T COMPUT BI, V16, P2078, DOI 10.1109/TCBB.2018.2831212
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Yamashita M, 2019, J DIABETES INVEST, V10, P1463, DOI 10.1111/jdi.13048
   Yasir M, 2015, NUTR DIABETES, V5, DOI 10.1038/nutd.2015.3
   Zeng Z, 2017, APPL MICROBIOL BIOT, V101, P7177, DOI 10.1007/s00253-017-8410-6
   Zhang F, 2017, J DAIRY SCI, V100, P1618, DOI 10.3168/jds.2016-11870
   Zhang XY, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0071108
   Zhang Y, 2020, BIORXIV PREPRINT
   Zheng PL, 2018, DIABETES-METAB RES, V34, DOI 10.1002/dmrr.3043
   Zhernakova A, 2016, SCIENCE, V352, P565, DOI 10.1126/science.aad3369
   Zhou J, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19102863
   2014, REG ANESTH PAIN MED, V9
NR 65
TC 17
Z9 16
U1 1
U2 11
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD OCT 30
PY 2020
VL 15
IS 10
AR e0241338
DI 10.1371/journal.pone.0241338
PG 19
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA OP8VN
UT WOS:000588368900025
PM 33125401
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Lee, H
   Lee, Y
   Kim, J
   An, J
   Lee, S
   Kong, H
   Song, Y
   Lee, CK
   Kim, K
AF Lee, Heetae
   Lee, Youngjoo
   Kim, Jiyeon
   An, Jinho
   Lee, Sungwon
   Kong, Hyunseok
   Song, Youngcheon
   Lee, Chong-Kil
   Kim, Kyungjae
TI Modulation of the gut microbiota by metformin improves metabolic
   profiles in aged obese mice
SO GUT MICROBES
LA English
DT Article
DE aged mice; Akkermansia muciniphila; extracellular vesicles; gut
   microbiota; metformin
ID CHAIN FATTY-ACID; AKKERMANSIA-MUCINIPHILA; INSULIN-RESISTANCE; DIET;
   IL-6; INDIVIDUALS; POPULATION; DIVERSITY; BUTYRATE; ADULTS
AB The gut microbiota is a contributing factor in obesity-related metabolic disorders. The effect of metformin on the gut microbiota has been reported; however, the relationship between the gut microbiota and the mechanism of action of metformin in elderly individuals is unclear. In this study, the effect of metformin on the gut microbiota was investigated in aged obese mice. The abundance of the genera Akkermansia, Bacteroides, Butyricimonas, and Parabacteroides was significantly increased by metformin in mice fed a high-fat diet. Metformin treatment decreased the expression of IL-1 beta and IL-6 in epididymal fat, which was correlated with the abundance of various bacterial genera. In addition, both fecal microbiota transplantation from metformin-treated mice and extracellular vesicles of Akkermansia muciniphila improved the body weight and lipid profiles of the mice. Our findings suggest that modulation of the gut microbiota by metformin results in metabolic improvements in aged mice, and that these effects are associated with inflammatory immune responses.
C1 [Lee, Heetae; Lee, Youngjoo; Kim, Jiyeon; An, Jinho; Lee, Sungwon; Kong, Hyunseok; Song, Youngcheon; Kim, Kyungjae] Sahmyook Univ, Coll Pharm, 815 Hwarang Ro, Seoul 01795, South Korea.
   [Lee, Chong-Kil] Chungbuk Natl Univ, Coll Pharm, Cheongju, South Korea.
C3 Sahmyook University; Chungbuk National University
RP Kim, K (通讯作者)，Sahmyook Univ, Coll Pharm, 815 Hwarang Ro, Seoul 01795, South Korea.
EM kimkj@syu.ac.kr
FU Korea Institute of Planning & Evaluation for Technology in Food,
   Agriculture, Forestry and Fisheries (iPET) [314044-3]
FX This work was supported by Korea Institute of Planning & Evaluation for
   Technology in Food, Agriculture, Forestry and Fisheries (iPET)
   (314044-3).
CR Belkaid Y, 2014, CELL, V157, P121, DOI 10.1016/j.cell.2014.03.011
   Biagi E, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0010667
   Brown K, 2012, NUTRIENTS, V4, P1095, DOI [10.3390/nu4081095, 10.3390/nu4111552]
   Cahenzli J, 2013, CELL HOST MICROBE, V14, P559, DOI 10.1016/j.chom.2013.10.004
   Cai DS, 2005, NAT MED, V11, P183, DOI 10.1038/nm1166
   Cani PD, 2009, CURR PHARM DESIGN, V15, P1546, DOI 10.2174/138161209788168164
   Caporaso JG, 2010, NAT METHODS, V7, P335, DOI 10.1038/nmeth.f.303
   Carding Simon, 2015, Microbial Ecology in Health and Disease, V26, P26191, DOI 10.3402/mehd.v26.26191
   Carnethon MR, 2004, DIABETES CARE, V27, P2707, DOI 10.2337/diacare.27.11.2707
   Clarke SF, 2012, GUT MICROBES, V3, P186, DOI 10.4161/gmic.20168
   Collado MC, 2007, APPL ENVIRON MICROB, V73, P7767, DOI 10.1128/AEM.01477-07
   Croswell A, 2009, INFECT IMMUN, V77, P2741, DOI 10.1128/IAI.00006-09
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   den Besten G, 2013, J LIPID RES, V54, P2325, DOI 10.1194/jlr.R036012
   Derrien M, 2004, INT J SYST EVOL MICR, V54, P1469, DOI 10.1099/ijs.0.02873-0
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Finlayson A, 2015, WORLD J GASTRO ENDOS, V7, P1103, DOI [10.4253/wjge.v7.i13.1103, 10.4291/wjgp.v6.i4.110]
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Gao ZG, 2009, DIABETES, V58, P1509, DOI 10.2337/db08-1637
   Gilbert JA, 2010, STAND GENOMIC SCI, V3, P249, DOI [10.4056/aigs.1443528, 10.4056/sigs.1433550]
   Greer RL, 2016, NAT COMMUN, V7, DOI 10.1038/ncomms13329
   Gregor MF, 2011, ANNU REV IMMUNOL, V29, P415, DOI 10.1146/annurev-immunol-031210-101322
   Hardie DG, 2012, NAT REV MOL CELL BIO, V13, P251, DOI 10.1038/nrm3311
   Hatayama H, 2007, BIOCHEM BIOPH RES CO, V356, P599, DOI 10.1016/j.bbrc.2007.03.025
   Jangi S, 2016, NAT COMMUN, V7, DOI 10.1038/ncomms12015
   Kang CS, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0076520
   Kasai C, 2015, BMC GASTROENTEROL, V15, DOI 10.1186/s12876-015-0330-2
   Lackey DE, 2016, NAT REV ENDOCRINOL, V12, P15, DOI 10.1038/nrendo.2015.189
   Layton A, 2006, APPL ENVIRON MICROB, V72, P4214, DOI 10.1128/AEM.01036-05
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Lin HP, 2012, PLOS ONE, V7, DOI [10.1371/journal.pone.0031286, 10.1371/journal.pone.0035240]
   Louis S, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0149564
   Lundberg R, 2016, GUT MICROBES, V7, P68, DOI 10.1080/19490976.2015.1127463
   Mardinoglu A, 2016, CELL METAB, V23, P10, DOI 10.1016/j.cmet.2015.12.012
   Mariat D, 2009, BMC MICROBIOL, V9, DOI 10.1186/1471-2180-9-123
   Mauer J, 2015, TRENDS IMMUNOL, V36, P92, DOI 10.1016/j.it.2014.12.008
   Ott SJ, 2004, GUT, V53, P685, DOI 10.1136/gut.2003.025403
   Plovier H, 2017, NAT MED, V23, P107, DOI 10.1038/nm.4236
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Rios-Covian D, 2013, APPL ENVIRON MICROB, V79, P7518, DOI 10.1128/AEM.02545-13
   Rotella CM, 2006, CURR DIABETES REV, V2, P307, DOI 10.2174/157339906777950651
   Rotter V, 2003, J BIOL CHEM, V278, P45777, DOI 10.1074/jbc.M301977200
   Scheller J, 2011, BBA-MOL CELL RES, V1813, P878, DOI 10.1016/j.bbamcr.2011.01.034
   Segata N, 2011, GENOME BIOL, V12, DOI 10.1186/gb-2011-12-6-r60
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Starr ME, 2015, J GERONTOL A-BIOL, V70, P1508, DOI 10.1093/gerona/glu197
   Stuckler D, 2008, MILBANK Q, V86, P273, DOI 10.1111/j.1468-0009.2008.00522.x
   Wang HD, 2016, LANCET, V388, P1459, DOI 10.1016/S0140-6736(16)31012-1
   Weigert C, 2005, AM J PHYSIOL-ENDOC M, V289, pE251, DOI 10.1152/ajpendo.00448.2004
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Xiao SM, 2014, FEMS MICROBIOL ECOL, V87, P357, DOI 10.1111/1574-6941.12228
   Zwielehner J, 2009, EXP GERONTOL, V44, P440, DOI 10.1016/j.exger.2009.04.002
NR 52
TC 93
Z9 97
U1 6
U2 63
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1949-0976
EI 1949-0984
J9 GUT MICROBES
JI Gut Microbes
PY 2018
VL 9
IS 2
BP 155
EP 165
DI 10.1080/19490976.2017.1405209
PG 11
WC Gastroenterology & Hepatology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Microbiology
GA GJ9ID
UT WOS:000435713000007
PM 29157127
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Kimber-Trojnar, Z
   Dluski, DF
   Wierzchowska-Opoka, M
   Ruszala, M
   Leszczynska-Gorzelak, B
AF Kimber-Trojnar, Zaneta
   Dluski, Dominik Franciszek
   Wierzchowska-Opoka, Magdalena
   Ruszala, Monika
   Leszczynska-Gorzelak, Bozena
TI Metformin as a Potential Treatment Option for Endometriosis
SO CANCERS
LA English
DT Review
DE endometriosis; medical therapy; metformin; inflammation
ID ACTIVATED PROTEIN-KINASE; FACTOR-KAPPA-B; MATRIX-METALLOPROTEINASE
   INHIBITOR; ENDOTHELIAL GROWTH-FACTOR; ACUTE REGULATORY PROTEIN;
   NECROSIS-FACTOR-ALPHA; STROMAL CELLS; AROMATASE EXPRESSION; GUT
   MICROBIOME; PERITONEAL-FLUID
AB Simple Summary The aim of this article is to present current knowledge regarding the possibilities of using metformin in the pharmacological treatment of endometriosis. Metformin is an insulin sensitizer widely used for the treatment of type 2 diabetes mellitus. The pleiotropic effects of metformin are mainly exerted through the activation of AMP-activated protein kinase, which is the key cellular energy homeostasis regulator that inhibits mTOR, a major autophagy suppressor. Metformin regresses endometriotic implants by increasing the activity of superoxide dismutase. It is also an inhibitor of metalloproteinase-2, decreasing the levels of the vascular endothelial growth factor and matrix metalloproteinase-9 in animal studies. With its unique therapeutic mechanisms and no serious side effects, metformin seems to be a helpful anti-inflammatory and anti-proliferative agent in the treatment of endometriosis. It could be a missing link for the successful treatment of this chronic disease. Endometriosis is a common disease in women of reproductive age, and its pathogenesis seems to be largely affected by hormone imbalance, inflammation, oxidative stress, and autophagy dysregulation. These pathophysiological disturbances interact with one another through mechanisms that are still awaiting elucidation. The aim of this article is to present current knowledge regarding the possibilities of using metformin in the pharmacological treatment of endometriosis. Metformin is an insulin sensitizer widely used for the treatment of type 2 diabetes mellitus. The pleiotropic effects of metformin are mainly exerted through the activation of AMP-activated protein kinase, which is the key cellular energy homeostasis regulator that inhibits mTOR, a major autophagy suppressor. Metformin regresses endometriotic implants by increasing the activity of superoxide dismutase. It is also an inhibitor of metalloproteinase-2, decreasing the levels of the vascular endothelial growth factor and matrix metalloproteinase-9 in animal studies. In endometriosis, metformin might modify the stroma-epithelium communication via Wnt2/beta-catenin. With its unique therapeutic mechanisms and no serious side effects, metformin seems to be a helpful anti-inflammatory and anti-proliferative agent in the treatment of endometriosis. It could be a missing link for the successful treatment of this chronic disease.
C1 [Kimber-Trojnar, Zaneta; Dluski, Dominik Franciszek; Wierzchowska-Opoka, Magdalena; Ruszala, Monika; Leszczynska-Gorzelak, Bozena] Med Univ Lublin, Chair & Dept Obstet & Perinatol, PL-20090 Lublin, Poland.
C3 Medical University of Lublin
RP Dluski, DF (通讯作者)，Med Univ Lublin, Chair & Dept Obstet & Perinatol, PL-20090 Lublin, Poland.
EM zkimber@poczta.onet.pl; p.l.casiraghi@wp.pl; magdaopoka11@gmail.com;
   monika.ruszala@wp.pl; b.leszczynska@umlub.pl
OI Dluski, Dominik/0000-0001-5886-2664; Kimber-Trojnar,
   Zaneta/0000-0001-7295-0409; Leszczynska-Gorzelak,
   Bozena/0000-0002-0221-1982
FU Medical University of Lublin [332,336]
FX FundingThis research was funded by the Medical University of Lublin,
   grant number 332,336.
CR Ahn SH, 2015, BIOMED RES INT, V2015, DOI 10.1155/2015/795976
   Alhowail A, 2021, EUR REV MED PHARMACO, V25, P4757, DOI 10.26355/eurrev_202107_26387
   Attar E, 2006, HUM REPROD UPDATE, V12, P49, DOI 10.1093/humupd/dmi034
   Attia GR, 2001, FERTIL STERIL, V76, P517, DOI 10.1016/S0015-0282(01)01975-6
   Bailey MT, 2002, HUM REPROD, V17, P1704, DOI 10.1093/humrep/17.7.1704
   Baker JM, 2017, MATURITAS, V103, P45, DOI 10.1016/j.maturitas.2017.06.025
   Barcz E, 2012, FERTIL STERIL, V97, P1380, DOI 10.1016/j.fertnstert.2012.03.057
   Bedaiwy MA, 2017, FERTIL STERIL, V107, P555, DOI 10.1016/j.fertnstert.2016.12.025
   Bergers G, 2005, NEURO-ONCOLOGY, V7, P452, DOI 10.1215/S1152851705000232
   Bergheim I, 2006, J PHARMACOL EXP THER, V316, P1053, DOI 10.1124/jpet.105.092122
   Bina F, 2019, PHARMACOL RES, V139, P76, DOI 10.1016/j.phrs.2018.11.008
   Borghese B, 2008, MOL ENDOCRINOL, V22, P2557, DOI 10.1210/me.2008-0322
   Brown KA, 2010, BREAST CANCER RES TR, V123, P591, DOI 10.1007/s10549-010-0834-y
   Brown KA, 2009, CANCER RES, V69, P5392, DOI 10.1158/0008-5472.CAN-09-0108
   Buchanan FG, 2003, J BIOL CHEM, V278, P35451, DOI 10.1074/jbc.M302474200
   Bulun SE, 2005, PHARMACOL REV, V57, P359, DOI 10.1124/pr.57.3.6
   Chen YH, 2021, MOL MED REP, V23, DOI 10.3892/mmr.2020.11725
   Chung AS, 2010, NAT REV CANCER, V10, P505, DOI 10.1038/nrc2868
   Collinet P, 2018, J GYNECOL OBSTET HUM, V47, P265, DOI 10.1016/j.jogoh.2018.06.003
   Congiu T, 2021, PHARMACEUTICS, V13, DOI 10.3390/pharmaceutics13060830
   Cusi K, 1996, J CLIN ENDOCR METAB, V81, P4059, DOI 10.1210/jc.81.11.4059
   Damman CJ, 2012, AM J GASTROENTEROL, V107, P1452, DOI 10.1038/ajg.2012.93
   DEITCH EA, 1990, ARCH SURG-CHICAGO, V125, P403
   Deveraux QL, 1998, EMBO J, V17, P2215, DOI 10.1093/emboj/17.8.2215
   Dhillon Samjot Singh, 2014, J Cancer Sci Ther, V6, P217
   Dull AM, 2019, MOLECULES, V24, DOI 10.3390/molecules24040667
   Eaton JL, 2013, J CLIN ENDOCR METAB, V98, pE1871, DOI 10.1210/jc.2013-1661
   Fadden EJ, 2021, BMJ CASE REP, V14, DOI 10.1136/bcr-2020-239154
   Falcone T, 2011, OBSTET GYNECOL, V118, P691, DOI 10.1097/AOG.0b013e31822adfd1
   Fan YY, 2018, GYNECOL ENDOCRINOL, V34, P507, DOI 10.1080/09513590.2017.1409717
   Flores R, 2012, J TRANSL MED, V10, DOI 10.1186/1479-5876-10-253
   Foda AA, 2012, MIDDLE EAST FERTIL S, V17, P262, DOI 10.1016/j.mefs.2012.09.001
   Fu YL, 2017, EUR REV MED PHARMACO, V21, P1169
   Gazvani R, 2002, REPRODUCTION, V123, P217, DOI 10.1530/rep.0.1230217
   Gebel HM, 1998, FERTIL STERIL, V69, P1042, DOI 10.1016/S0015-0282(98)00073-9
   Goenka L, 2017, BIOMED PHARMACOTHER, V90, P575, DOI 10.1016/j.biopha.2017.03.092
   Gunton JE, 2003, J CLIN ENDOCR METAB, V88, P1323, DOI 10.1210/jc.2002-021394
   Guo M, 2020, INT J MOL MED, V45, P623, DOI 10.3892/ijmm.2019.4438
   Hadler-Olsen E, 2013, TUMOR BIOL, V34, P2041, DOI 10.1007/s13277-013-0842-8
   Harada A, 2010, BIOMACROMOLECULES, V11, P1036, DOI 10.1021/bm1000108
   Hardie DG, 2012, CHEM BIOL, V19, P1222, DOI 10.1016/j.chembiol.2012.08.019
   Hayashi A, 2012, J OVARIAN RES, V5, DOI 10.1186/1757-2215-5-31
   Herbsleb M, 2008, BMC MED GENOMICS, V1, DOI 10.1186/1755-8794-1-31
   Hinshelwood MM, 1997, ENDOCRINOLOGY, V138, P3704, DOI 10.1210/en.138.9.3704
   Holdsworth-Carson SJ, 2018, J ENDOMETR PELVIC PA, V10, P79, DOI 10.1177/2284026518773939
   Hsiao KY, 2014, HUM REPROD, V29, P2747, DOI 10.1093/humrep/deu255
   Huang GN, 2017, TOXICOL APPL PHARM, V332, P138, DOI 10.1016/j.taap.2017.04.009
   Hundal RS, 2000, DIABETES, V49, P2063, DOI 10.2337/diabetes.49.12.2063
   Hunzicker-Dunn M, 2006, CELL SIGNAL, V18, P1351, DOI 10.1016/j.cellsig.2006.02.011
   Iba Y, 2004, FERTIL STERIL, V82, P1036, DOI 10.1016/j.fertnstert.2004.04.038
   Irie H, 2016, ONCOL LETT, V11, P1287, DOI 10.3892/ol.2016.4075
   Isoda K, 2006, ARTERIOSCL THROM VAS, V26, P611, DOI 10.1161/01.ATV.0000201938.78044.75
   Jalving M, 2010, EUR J CANCER, V46, P2369, DOI 10.1016/j.ejca.2010.06.012
   Jamali N, 2021, REPROD SCI, V28, P683, DOI 10.1007/s43032-020-00377-2
   Jana S, 2012, INDIAN J BIOCHEM BIO, V49, P342
   Jia LJ, 2018, LIFE SCI, V208, P123, DOI 10.1016/j.lfs.2018.07.027
   Jin YP, 2004, HUM IMMUNOL, V65, P291, DOI 10.1016/j.humimm.2004.01.002
   Jones RG, 2000, J EXP MED, V191, P1721, DOI 10.1084/jem.191.10.1721
   Kalu E, 2007, J OBSTET GYNAECOL RE, V33, P490, DOI 10.1111/j.1447-0756.2007.00569.x
   Kasznicki J, 2014, ANN TRANSL MED, V2, DOI 10.3978/j.issn.2305-5839.2014.06.01
   Kerbel RS, 2008, NEW ENGL J MED, V358, P2039, DOI 10.1056/NEJMra0706596
   Khan KN, 2016, EUR J OBSTET GYN R B, V199, P69, DOI 10.1016/j.ejogrb.2016.01.040
   Khan KN, 2005, HUM REPROD, V20, P2715, DOI 10.1093/humrep/dei156
   Kim YC, 2015, J CLIN INVEST, V125, P25, DOI 10.1172/JCI73939
   Kimber-Trojnar Z, 2021, J CLIN MED, V10, DOI 10.3390/jcm10132762
   Klappan AK, 2012, HISTOCHEM CELL BIOL, V137, P25, DOI 10.1007/s00418-011-0869-0
   Kobayashi H, 2014, ARCH GYNECOL OBSTET, V289, P13, DOI 10.1007/s00404-013-3049-8
   Kola B, 2006, TRENDS ENDOCRIN MET, V17, P205, DOI 10.1016/j.tem.2006.05.006
   Kyama CM, 2008, FERTIL STERIL, V89, P301, DOI 10.1016/j.fertnstert.2007.02.057
   Lagana AS, 2017, MED HYPOTHESES, V103, P10, DOI 10.1016/j.mehy.2017.03.032
   Lagana AS, 2017, EXPERT OPIN DRUG MET, V13, P593, DOI 10.1080/17425255.2017.1297421
   Laschke MW, 2016, AM J OBSTET GYNECOL, V215, DOI 10.1016/j.ajog.2016.02.036
   Lasticova Martina, 2020, Vnitr Lek, V66, P438
   Li SMH, 2018, J BIOMED SCI, V25, DOI 10.1186/s12929-018-0478-5
   Lin HZ, 2000, NAT MED, V6, P998, DOI 10.1038/79697
   Lord J, 2004, CURR OPIN OBSTET GYN, V16, P481, DOI 10.1097/00001703-200412000-00008
   Lousse JC, 2008, FERTIL STERIL, V90, P217, DOI 10.1016/j.fertnstert.2007.06.015
   Ma RL, 2021, CHINESE MED J-PEKING, V134, P2882, DOI 10.1097/CM9.0000000000001712
   Maida A, 2011, DIABETOLOGIA, V54, P339, DOI 10.1007/s00125-010-1937-z
   Manna PR, 2006, MOL ENDOCRINOL, V20, P362, DOI 10.1210/me.2004-0526
   Mansfield R, 2003, FERTIL STERIL, V79, P956, DOI 10.1016/S0015-0282(02)04925-7
   Markle JGM, 2013, SCIENCE, V339, P1084, DOI 10.1126/science.1233521
   Martinelle N, 2004, ENDOCRINOLOGY, V145, P4629, DOI 10.1210/en.2004-0496
   Masuda S, 2011, J CELL SCI, V124, P548, DOI 10.1242/jcs.072058
   Matsuzaki S, 2015, HUM REPROD, V30, P1606, DOI 10.1093/humrep/dev108
   Mayerhofer M, 2002, BLOOD, V100, P3767, DOI 10.1182/blood-2002-01-0109
   McKinnon B, 2014, J MOL ENDOCRINOL, V52, P169, DOI 10.1530/JME-13-0194
   Melo AS, 2010, FERTIL STERIL, V93, P2433, DOI 10.1016/j.fertnstert.2009.08.043
   Mori T, 2002, ANTICANCER RES, V22, P3985
   Mori T, 2001, EXP BIOL MED, V226, P429, DOI 10.1177/153537020122600506
   Morin-Papunen L, 2012, J CLIN ENDOCR METAB, V97, P1492, DOI 10.1210/jc.2011-3061
   Moschetta MG, 2019, ANTI-CANCER AGENT ME, V19, P655, DOI 10.2174/1871520619666181218164050
   Natali A, 2006, DIABETOLOGIA, V49, P434, DOI 10.1007/s00125-006-0141-7
   Noble LS, 1997, J CLIN ENDOCR METAB, V82, P600, DOI 10.1210/jc.82.2.600
   Omer NA, 2016, IRAQ J PHARM SCI, V25, P28
   Oner G, 2010, HUM REPROD, V25, P932, DOI 10.1093/humrep/deq016
   Orecchioni S, 2015, INT J CANCER, V136, pE534, DOI 10.1002/ijc.29193
   Owen MD, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22115759
   Park YB, 2006, RESPIROLOGY, V11, P221, DOI 10.1111/j.1440-1843.2006.00829.x
   Patel BG, 2017, ACTA OBSTET GYN SCAN, V96, P623, DOI 10.1111/aogs.13156
   Paul S, 2008, J PINEAL RES, V44, P439, DOI 10.1111/j.1600-079X.2007.00547.x
   Plottel CS, 2011, CELL HOST MICROBE, V10, P324, DOI 10.1016/j.chom.2011.10.003
   Qian WK, 2018, LIFE SCI, V208, P253, DOI 10.1016/j.lfs.2018.07.046
   Qu HM, 2015, CELL BIOCHEM BIOPHYS, V71, P931, DOI 10.1007/s12013-014-0287-8
   Rattan R, 2011, NEOPLASIA, V13, P483, DOI 10.1593/neo.11148
   Reiss Y, 2005, BRAIN PATHOL, V15, P311
   Ren Y, 2021, SAGE OPEN MED, V9, DOI 10.1177/20503121211001641
   Rice S, 2013, J CLIN ENDOCR METAB, V98, pE1491, DOI 10.1210/jc.2013-1865
   Rice S, 2009, ENDOCRINOLOGY, V150, P4794, DOI 10.1210/en.2009-0540
   Romashkova JA, 1999, NATURE, V401, P86, DOI 10.1038/43474
   Rooprai HK, 1997, ANTICANCER RES, V17, P4151
   Rotermund C, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00400
   Samimi M, 2019, J CELL PHYSIOL, V234, P19384, DOI 10.1002/jcp.28666
   Santulli P, 2012, FERTIL STERIL, V97, P904, DOI 10.1016/j.fertnstert.2011.12.051
   Saunders PTK, 2021, CELL, V184, P2807, DOI 10.1016/j.cell.2021.04.041
   Sayed Rana, 2015, Asian Pac J Cancer Prev, V16, P6621
   Schwabe RF, 2013, NAT REV CANCER, V13, P800, DOI 10.1038/nrc3610
   Sebastian S, 2001, J CLIN ENDOCR METAB, V86, P4600, DOI 10.1210/jc.86.10.4600
   Seracchioli R, 2018, FERTIL STERIL, V109, P1135, DOI 10.1016/j.fertnstert.2018.02.122
   Sharma A, 2021, CLIN CASE REP, V9, DOI 10.1002/ccr3.4621
   Shikone T, 1996, J CLIN ENDOCR METAB, V81, P2376, DOI 10.1210/jc.81.6.2376
   Shimada H, 2016, ONCOTARGET, V7, P27735, DOI 10.18632/oncotarget.8408
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Shoshan-Barmatz V, 2021, FRONT PHYSIOL, V12, DOI 10.3389/fphys.2021.730048
   Sikora J, 2017, AM J REPROD IMMUNOL, V77, DOI 10.1111/aji.12622
   Sikora J, 2016, J CLIN LAB ANAL, V30, P831, DOI 10.1002/jcla.21944
   Sirianni R, 2007, CANCER RES, V67, P8368, DOI 10.1158/0008-5472.CAN-06-4064
   Slahor Lea, 2021, Praxis (Bern 1994), V110, P939, DOI 10.1024/1661-8157/a003774
   Soares SR, 2012, FERTIL STERIL, V98, P529, DOI 10.1016/j.fertnstert.2012.07.1120
   Stochino-Loi E, 2021, FRONT MED-LAUSANNE, V8, DOI 10.3389/fmed.2021.581311
   Storozhuk Y, 2013, BRIT J CANCER, V108, P2021, DOI 10.1038/bjc.2013.187
   Streuli I, 2017, CLIMACTERIC, V20, P138, DOI 10.1080/13697137.2017.1284781
   Sun HS, 2003, ENDOCRINOLOGY, V144, P3934, DOI 10.1210/en.2003-0289
   Takemura Y, 2005, HUM REPROD, V20, P3510, DOI 10.1093/humrep/dei233
   Takemura Y, 2005, AM J REPROD IMMUNOL, V54, P217, DOI 10.1111/j.1600-0897.2005.00300.x
   Takemura Y, 2007, J CLIN ENDOCR METAB, V92, P3213, DOI 10.1210/jc.2006-2486
   Takemura Y, 2006, ENDOCRINOLOGY, V147, P3203, DOI 10.1210/en.2005-1510
   Tarry-Adkins JL, 2021, DIABETES THER, V12, P1901, DOI 10.1007/s13300-021-01058-2
   Tosca L, 2007, BIOL REPROD, V77, P452, DOI 10.1095/biolreprod.107.060848
   Tosca L, 2007, BIOL REPROD, V76, P368, DOI 10.1095/biolreprod.106.055749
   Tosca L, 2006, BIOL REPROD, V75, P342, DOI 10.1095/biolreprod.106.050831
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Vallee A, 2021, PHARMACEUTICALS-BASE, V14, DOI 10.3390/ph14060543
   Vallee A, 2019, J EXP CLIN CANC RES, V38, DOI 10.1186/s13046-019-1320-y
   Vallee A, 2018, REV NEUROSCIENCE, V29, P71, DOI 10.1515/revneuro-2017-0032
   Vaskivuo TE, 2000, MOL CELL ENDOCRINOL, V165, P75, DOI 10.1016/S0303-7207(00)00261-6
   Vercellini P, 2016, FERTIL STERIL, V105, P734, DOI 10.1016/j.fertnstert.2015.11.016
   Vetvicka V, 2016, ARCH GYNECOL OBSTET, V294, P897, DOI 10.1007/s00404-016-4195-6
   Viollet B, 2012, CLIN SCI, V122, P253, DOI 10.1042/CS20110386
   Vitagliano A, 2015, J ASSIST REPROD GEN, V32, P407, DOI 10.1007/s10815-014-0412-z
   Wang DZ, 2016, TRENDS MOL MED, V22, P1, DOI 10.1016/j.molmed.2015.11.003
   Wang JC, 2019, J EXP CLIN CANC RES, V38, DOI 10.1186/s13046-019-1211-2
   Wang NN, 2014, BIOMED RES INT, V2014, DOI 10.1155/2014/546479
   Wu MH, 2005, AM J PATHOL, V167, P1061, DOI 10.1016/S0002-9440(10)61195-9
   Wu MH, 2005, J CLIN ENDOCR METAB, V90, P286, DOI 10.1210/jc.2004-1612
   Xiao XX, 2012, GYNECOL ONCOL, V127, P249, DOI 10.1016/j.ygyno.2012.06.032
   Xu JN, 2014, J CLIN ENDOCR METAB, V99, P2795, DOI 10.1210/jc.2014-1593
   Yao M, 2003, CANCER RES, V63, P586
   Yari S, 2021, EXP CELL RES, V404, DOI 10.1016/j.yexcr.2021.112659
   Yehya AHS, 2018, MEDICINA-LITHUANIA, V54, DOI 10.3390/medicina54010008
   Yilmaz B, 2010, AM J OBSTET GYNECOL, V202, DOI 10.1016/j.ajog.2009.10.873
   Zhang H, 2015, MOL CELL ENDOCRINOL, V413, P61, DOI 10.1016/j.mce.2015.06.011
   Zhang HH, 2018, MOL CARCINOGEN, V57, P44, DOI 10.1002/mc.22718
   Zhang Q, 2009, AM J OBSTET GYNECOL, V200, DOI 10.1016/j.ajog.2008.08.064
   Zhao Y, 2018, GYNECOL ENDOCRINOL, V34, P428, DOI 10.1080/09513590.2017.1409714
   Zhou Y, 2015, REPROD SCI, V22, P1162, DOI 10.1177/1933719115590664
   Zong WX, 1999, GENE DEV, V13, P382, DOI 10.1101/gad.13.4.382
NR 167
TC 8
Z9 9
U1 1
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6694
J9 CANCERS
JI Cancers
PD FEB
PY 2022
VL 14
IS 3
AR 577
DI 10.3390/cancers14030577
PG 19
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA ZA2CN
UT WOS:000755974800001
PM 35158846
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Wu, B
   Chen, MY
   Gao, YC
   Hu, JL
   Liu, MZ
   Zhang, W
   Huang, WH
AF Wu, Bin
   Chen, ManYun
   Gao, YongChao
   Hu, JingLei
   Liu, MouZe
   Zhang, Wei
   Huang, WeiHua
TI In vivo pharmacodynamic and pharmacokinetic effects of metformin
   mediated by the gut microbiota in rats
SO LIFE SCIENCES
LA English
DT Article
DE Metformin; Gut microbiota; Pharmacokinetics; Pharmacodynamics; Oct1
ID GERM-FREE; RESISTANCE; OBESITY; MODEL
AB Aims: The gut microbiota plays a crucial role in the efficacy of metformin in T2DM treatment. We evaluated whether the pharmacodynamics and pharmacokinetics of metformin are mediated by gut microbiota.
   Main methods: We used conventional diabetic and pseudo-germ-free rats. After 6 weeks of metformin treatment, pharmacodynamic indexes were determined. Metformin concentrations were measured with a validated HPLC-MS/MS method after the first oral administration.
   Key findings: Most endpoints were similar between vehicle-treated diabetic and vehicle-treated pseudo-germfree diabetic rats. However, after 6 weeks of metformin treatment, compared with conventional diabetic rats, pseudo-germ-free diabetic rats exhibited significantly increased FBG, decreased oral glucose, reduced GSP, worsened insulin resistance, increased hyperlipidemia, and increased hepatic steatosis severity. Moreover, the Cmax of pseudo-germ-free rats increased significantly, while the t1/2 alpha decreased significantly. These pharmacodynamic and pharmacokinetic changes were probably due to a decrease in Oct1 expression in the liver, resulting in altered hepatic uptake of metformin in vivo.
   Significance: These results implied that the gut microbiota may play an important role in the pharmacodynamics and pharmacokinetics of metformin and that the changes in these properties are probably due to Oct1 down-regulation in the livers of pseudo-germ-free rats.
C1 [Wu, Bin; Chen, ManYun; Gao, YongChao; Hu, JingLei; Liu, MouZe; Zhang, Wei; Huang, WeiHua] Cent South Univ, Xiangya Hosp, Dept Clin Pharmacol, 110 Xiangya St, Changsha 410078, Hunan, Peoples R China.
   [Wu, Bin; Chen, ManYun; Gao, YongChao; Hu, JingLei; Liu, MouZe; Zhang, Wei; Huang, WeiHua] Cent South Univ, Hunan Key Lab Pharmacogenet, Inst Clin Pharmacol, Changsha, Hunan, Peoples R China.
   [Wu, Bin; Chen, ManYun; Gao, YongChao; Hu, JingLei; Liu, MouZe; Zhang, Wei; Huang, WeiHua] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr, Changsha 410008, Hunan, Peoples R China.
C3 Central South University; Central South University; Central South
   University
RP Zhang, W; Huang, WH (通讯作者)，Cent South Univ, Xiangya Hosp, Dept Clin Pharmacol, 110 Xiangya St, Changsha 410078, Hunan, Peoples R China.
EM yjsd2003@163.com; endeavor34852@aliyun.com
RI Yongchao, Gao/HJI-3081-2023; Gao, Yongchao/HJI-3117-2023
OI Yongchao, Gao/0000-0002-1631-7390; Huang, Wei-Hua/0000-0003-4167-8304
FU National Key Research and Development Program [2016YFC0905000,
   2016YFC0905001]; Central South University Innovation Foundation for
   Postgraduates [2015zzts117]
FX This research was supported by grants from the National Key Research and
   Development Program (Nos. 2016YFC0905000 and 2016YFC0905001) and the
   Central South University Innovation Foundation for Postgraduates
   (2015zzts117).
CR Backhed F, 2007, P NATL ACAD SCI USA, V104, P979, DOI 10.1073/pnas.0605374104
   Cabreiro F, 2016, CELL HOST MICROBE, V19, P1, DOI 10.1016/j.chom.2015.12.012
   Cho SK, 2011, CLIN PHARMACOL THER, V89, P416, DOI 10.1038/clpt.2010.266
   Chung H., 2018, NONLINEAR PHARMACOKI, V13
   Dao MC, 2016, GUT, V65, P426, DOI 10.1136/gutjnl-2014-308778
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Hamdy DA, 2011, J PHARM SCI-US, V100, P4986, DOI 10.1002/jps.22675
   Hanley AJG, 2002, DIABETES CARE, V25, P1177, DOI 10.2337/diacare.25.7.1177
   Jiang YL, 2014, INT J BIOL SCI, V10, P268, DOI 10.7150/ijbs.7929
   Jiao YK, 2017, J ETHNOPHARMACOL, V199, P119, DOI 10.1016/j.jep.2017.02.003
   Kuno T, 2016, MOL PHARMACEUT, V13, P2691, DOI 10.1021/acs.molpharmaceut.6b00259
   Li R, 2016, BIOCHEM BIOPH RES CO, V478, P1173, DOI 10.1016/j.bbrc.2016.08.087
   Maruthur NM, 2016, ANN INTERN MED, V164, P740, DOI 10.7326/M15-2650
   Miller RA, 2013, NATURE, V494, P256, DOI 10.1038/nature11808
   Nativ NI, 2014, LIVER TRANSPLANT, V20, P228, DOI 10.1002/lt.23782
   Oh J, 2016, DIABETES OBES METAB, V18, P104, DOI 10.1111/dom.12577
   PENTIKAINEN PJ, 1979, EUR J CLIN PHARMACOL, V16, P195, DOI 10.1007/BF00562061
   Plovier H, 2017, NAT MED, V23, P107, DOI 10.1038/nm.4236
   Reikvam DH, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0017996
   Sampson TR, 2016, CELL, V167, P1469, DOI 10.1016/j.cell.2016.11.018
   Shen TCD, 2015, J CLIN INVEST, V125, P2841, DOI 10.1172/JCI79214
   Wang YW, 2004, J CHROMATOGR B, V808, P215, DOI 10.1016/j.jchromb.2004.05.006
   Yang SK, 2017, CURR MED CHEM, V24, P3185, DOI [10.2174/0929867324666170509121003, 10.2174/0919867314666170509111003]
   Yano JM, 2015, CELL, V161, P264, DOI 10.1016/j.cell.2015.02.047
   Zhang YF, 2014, DIABETES CARE, V37, P2804, DOI 10.2337/dc14-0090
   Zhou GC, 2001, J CLIN INVEST, V108, P1167, DOI 10.1172/JCI200113505
NR 26
TC 20
Z9 22
U1 3
U2 41
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD JUN 1
PY 2019
VL 226
BP 185
EP 192
DI 10.1016/j.lfs.2019.04.009
PG 8
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA HU8TS
UT WOS:000465564200019
PM 30953641
DA 2023-06-08
ER

PT J
AU Lyu, YF
   Li, D
   Li, ZW
   Zhang, J
   Ming, X
   Shaw, PC
   Zhang, CB
   Kong, APS
   Zuo, Z
AF Lyu, Yuanfeng
   Li, Dan
   Li, Ziwei
   Zhang, Jun
   Ming, Xing
   Shaw, Pang Chui
   Zhang, Chunbo
   Kong, Alice Pik Shan
   Zuo, Zhong
TI Effects of combination treatment with metformin and berberine on
   hypoglycemic activity and gut microbiota modulation in db/db mice
SO PHYTOMEDICINE
LA English
DT Article
DE Metformin; Berberine; Gut microbiota; db/db mice; Treatment; In vivo
AB Background: Gut microbiota alterations could influence the metabolism of administered drugs, leading to their altered pharmacokinetics and pharmacodynamics. Despite that metformin and berberine has individually demonstrated their impacts on hypoglycemic activities and gut microbiota alterations in diabetic mice, investigation regarding the impact of their combination treatment in diabetic treatment has never been conducted.
   Purpose: Our current study was proposed aiming to investigate the effect of combination use of metformin with berberine on hypoglycemic activity and identify the possible intestinal bacteria involved in their microbiotamedicated drug-drug interactions in db/db mice.
   Study Design: Pharmacodynamics interactions between metformin and berberine were evaluated in six groups of db/db mice (db, M250, B250, B125, B250+M250, and B125+M250) with its wild type (WT) as control to receive 14 days treatment of vehicle, metformin at 250 mg/kg, berberine at 250/125 mg/kg, and metformin (250 mg/ kg) 2 h after dosing berberine (250/125 mg/kg).
   Methods: On day 13, insulin tolerance test (ITT) was conducted. On day 15, fasting serum samples were obtained for insulin concentration determination followed by intraperitoneal glucose tolerance test (ipGTT), homeostatic model assessment for insulin resistance (HOMA-IR) calculation, and feces collection for microbial 16S rRNA sequencing analyses. In addition, metformin steady state plasma concentrations on day 15 were measured by validated LC-MS/MS method.
   Results: Combination treatment of metformin with berberine could further reduce in blood glucose in comparison to that of db/db diabetic control. Further microbial 16S rRNA sequencing analyses revealed that gut microbiota compositions were significantly changed with the abundance of Proteobacteria and Verrucomicrobia altered the most after metformin and berberine co-treatment compared to their monotherapy. In addition, steady state metformin concentrations in their combination treatment were significantly higher than that from metformin monotherapy.
   Conclusion: Co-administration of metformin (250 mg/kg) with berberine (125 mg/kg) could not only further improve insulin sensitivity, but also demonstrate different alterations on gut microbial communities than that of their individual treatment in db/db mice.
C1 [Lyu, Yuanfeng; Li, Dan; Li, Ziwei; Zhang, Jun; Zuo, Zhong] Chinese Univ Hong Kong, Fac Med, Sch Pharm, Shatin, Hong Kong, Peoples R China.
   [Ming, Xing; Kong, Alice Pik Shan] Chinese Univ Hong Kong, Fac Med, Dept Med & Therapeut, Div Endocrinol,Shatin, Hong Kong, Peoples R China.
   [Shaw, Pang Chui] Chinese Univ Hong Kong, Sch Life Sci, Shatin, Hong Kong, Peoples R China.
   [Shaw, Pang Chui; Zhang, Chunbo] Nanchang Univ, Sch Pharm, Nanchang, Jiangxi Provinc, Peoples R China.
   [Zhang, Chunbo] Chinese Univ Hong Kong, Li Dak Sum Yip Yio Chin R&D Ctr Chinese Med, Shatin, Hong Kong, Peoples R China.
C3 Chinese University of Hong Kong; Chinese University of Hong Kong;
   Chinese University of Hong Kong; Nanchang University; Chinese University
   of Hong Kong
RP Zuo, Z (通讯作者)，Chinese Univ Hong Kong, Fac Med, Sch Pharm, Shatin, Hong Kong, Peoples R China.
EM joanzuo@cuhk.edu.hk
RI Ming, Xing/GQZ-6385-2022
OI Zhang, Chunbo/0000-0001-9618-9415
FU Li Dak Sum Yip Yio Chin R&D centre for Chinese Medicine at The Chinese
   University of Hong Kong
FX This work was partially supported by Li Dak Sum Yip Yio Chin R&D centre
   for Chinese Medicine at The Chinese University of Hong Kong.
CR Aydin O, 2018, CURR DIABETES REP, V18, DOI 10.1007/s11892-018-1020-6
   Borai A, 2007, ANN CLIN BIOCHEM, V44, P324, DOI 10.1258/000456307780945778
   Byndloss MX, 2018, MUCOSAL IMMUNOL, V11, P1299, DOI 10.1038/s41385-018-0010-y
   Chen YX, 2020, LANCET GASTROENTEROL, V5, P267, DOI 10.1016/S2468-1253(19)30409-1
   CP, 2015, CHINESE PHARMACOPOEI, V1, P303
   Dong H, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/591654
   FDA, 2005, FOOD DRUG ADM GUID I
   Geurts L, 2011, FRONT
   Graessler J, 2013, PHARMACOGENOMICS J, V13, P514, DOI 10.1038/tpj.2012.43
   Guo Y, 2016, BMC COMPLEM ALTERN M, V16, DOI 10.1186/s12906-016-1367-7
   Gurung M, 2020, EBIOMEDICINE, V51, DOI 10.1016/j.ebiom.2019.11.051
   Kheir MM, 2010, FOOD CHEM TOXICOL, V48, P1105, DOI 10.1016/j.fct.2010.01.033
   Lan JR, 2015, J ETHNOPHARMACOL, V161, P69, DOI 10.1016/j.jep.2014.09.049
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Li CN, 2020, PHYTOTHER RES, V34, P1166, DOI 10.1002/ptr.6588
   Li M, 2020, BIOMED PHARMACOTHER, V132, DOI 10.1016/j.biopha.2020.110953
   Li Q, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-62224-3
   Lyu YF, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.684358
   Lyu YF, 2019, LIFE SCI, V235, DOI 10.1016/j.lfs.2019.116818
   Ma BL, 2016, SCI REP-UK, V6, DOI 10.1038/srep20110
   Pernicova I, 2014, NAT REV ENDOCRINOL, V10, P143, DOI 10.1038/nrendo.2013.256
   Tilg H, 2014, GUT, V63, P1513, DOI 10.1136/gutjnl-2014-306928
   Vallianou NG, 2019, HORM-INT J ENDOCRINO, V18, P141, DOI 10.1007/s42000-019-00093-w
   Vinue A, 2015, METHODS MOL BIOL, V1339
   Wong JMW, 2006, J CLIN GASTROENTEROL, V40, P235, DOI 10.1097/00004836-200603000-00015
   Wu H, 2017, CONTRIBUTING
   Yin J, 2008, METABOLISM, V57, P712, DOI 10.1016/j.metabol.2008.01.013
   Yu F, 2019, AGING-US, V11, P10454, DOI 10.18632/aging.102469
   Zhang J, 2019, CNS NEUROSCI THER, V25, P685, DOI 10.1111/cns.13103
   Zhang W, 2019, BIOMED PHARMACOTHER, V118, DOI 10.1016/j.biopha.2019.109131
   Zhang X, 2012, PLOS ONE, V7, DOI [10.1371/journal.pone.0040320, 10.1371/journal.pone.0042529]
NR 31
TC 4
Z9 4
U1 9
U2 16
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0944-7113
EI 1618-095X
J9 PHYTOMEDICINE
JI Phytomedicine
PD JUL
PY 2022
VL 101
AR 154099
DI 10.1016/j.phymed.2022.154099
EA APR 2022
PG 9
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA 1F3NX
UT WOS:000795078900002
PM 35489323
DA 2023-06-08
ER

PT J
AU Makizaki, Y
   Maeda, A
   Yamamoto, M
   Tamura, S
   Tanaka, Y
   Nakajima, S
   Ohno, H
AF Makizaki, Yutaka
   Maeda, Ayako
   Yamamoto, Miyuki
   Tamura, Saya
   Tanaka, Yoshiki
   Nakajima, Shunji
   Ohno, Hiroshi
TI Bifidobacterium bifidum G9-1 ameliorates soft feces induced by metformin
   without affecting its antihyperglycemic action
SO BIOSCIENCE OF MICROBIOTA FOOD AND HEALTH
LA English
DT Article
DE Bifidobacterium bifidum G9-1; diarrhea; metformin; microbiota;
   Akkermansia
ID ANTIBIOTIC-ASSOCIATED DIARRHEA; MICROBIOTA; C57BL/6J
AB Recent studies of metformin, the first-line drug for type 2 diabetes, have reported the involvement of gut microbiota in the mechanism underlying its antihyperglycemic effect. However, the mechanisms underlying the development of diarrhea and bloating, which are adverse effects of metformin, are unclear, and these effects decrease the quality of life of metformin-receiving patients with diabetes. In this study, we focused on the effects of metformin on gut microbiota. Namely, we examined the effects of Bifidobacterium bifidum G9-1 (BBG9-1), which has the ability to improve dysbiosis, on the changes in gut microbiota and occurrence of soft feces (increased fecal water content) during the administration of metformin. The results showed that coadministration of BBG9-1 and metformin suppressed metformin-mediated changes in the gut microbiota and, thus, soft feces. Meanwhile, BBG9-1 did not influence the antihyperglycemic effect of metformin. Based on these results, we believe that BBG9-1, which could improve gut microbiota, suppresses metformin-induced soft feces without influencing the drug's antihyperglycemic effect.
C1 [Makizaki, Yutaka; Maeda, Ayako; Yamamoto, Miyuki; Tamura, Saya; Tanaka, Yoshiki; Nakajima, Shunji; Ohno, Hiroshi] Biofermin Pharmaceut Co Ltd, R&D Ctr, Nishi Ku, 7-3-4 Higashi Machi, Kobe, Hyogo 6512242, Japan.
RP Tanaka, Y (通讯作者)，Biofermin Pharmaceut Co Ltd, R&D Ctr, Nishi Ku, 7-3-4 Higashi Machi, Kobe, Hyogo 6512242, Japan.
EM tanaka_yoshiki@biofermin.co.jp
CR American Diabetes Association, 2019, Clin Diabetes, V37, P11, DOI 10.2337/cd18-0105
   Braun T, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-01217-1
   Caporaso JG, 2010, NAT METHODS, V7, P335, DOI 10.1038/nmeth.f.303
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Derrien M, 2015, BERGEYS MANUAL SYSTE
   Fadrosh DW, 2014, MICROBIOME, V2, DOI 10.1186/2049-2618-2-6
   FAO/WHO Working Group, 2002, REPORT JOINT FAO WHO
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Fukui H, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-30943-3
   Gallou-Kabani C, 2007, OBESITY, V15, P1996, DOI 10.1038/oby.2007.238
   Gao XW, 2010, AM J GASTROENTEROL, V105, P1636, DOI 10.1038/ajg.2010.11
   Gravet A, 1999, J CLIN MICROBIOL, V37, P4012, DOI 10.1128/JCM.37.12.4012-4019.1999
   Hashimoto Y, 2016, ENDOCRINE, V52, P271, DOI 10.1007/s12020-015-0786-4
   Katoh K, 2018, SCI TECHNOL ENERG MA, V79, P43
   Kiyohara M, 2012, J BIOL CHEM, V287, P693, DOI 10.1074/jbc.M111.277384
   Makizaki Y, 2019, BIOSCI MICROB FOOD H, V38, P49, DOI 10.12938/bmfh.18-020
   More MI, 2015, CLIN EXP GASTROENTER, V8, P237, DOI 10.2147/CEG.S85574
   Nakano Y, 2016, MOD MED, V62, P11
   Okayasu S, 2012, BIOL PHARM BULL, V35, P933
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Suchodolski JS, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0051907
   SURWIT RS, 1988, DIABETES, V37, P1163, DOI 10.2337/diabetes.37.9.1163
   Wu TZ, 2017, DIABETES OBES METAB, V19, P290, DOI 10.1111/dom.12812
   Zhang WD, 2018, FRONT IMMUNOL, V9, DOI 10.3389/fimmu.2018.01040
   Zhang XQ, 2015, SCI REP-UK, V5, DOI 10.1038/srep10737
NR 25
TC 5
Z9 5
U1 1
U2 6
PU BMFH PRESS
PI TOKYO
PA ATTN-BMFH, EDITORIAL OFF IPEC INC, 1-24-12 SUGAMO,TOSHIMA-KU, TOKYO,
   170-0002, JAPAN
SN 2186-6953
EI 2186-3342
J9 BIOSCI MICROB FOOD H
JI Biosci. Microbiota Food Health
PY 2020
VL 39
IS 3
BP 145
EP 151
DI 10.12938/bmfh.2019-022
PG 7
WC Microbiology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology; Nutrition & Dietetics
GA MU4CG
UT WOS:000555617500011
PM 32775133
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Cuyas, E
   Verdura, S
   Martin-Castillo, B
   Menendez, JA
AF Cuyas, Elisabet
   Verdura, Sara
   Martin-Castillo, Begona
   Menendez, Javier A.
TI Metformin: Targeting the Metabolo-Epigenetic Link in Cancer Biology
SO FRONTIERS IN ONCOLOGY
LA English
DT Review
DE metformin; metabolism; epigenetics; chromatin; cancer; diet; microbiota
AB Metabolism can directly drive or indirectly enable an aberrant chromatin state of cancer cells. The physiological and molecular principles of the metabolic link to epigenetics provide a basis for pharmacological modulation with the anti-diabetic biguanide metformin. Here, we briefly review how metabolite-derived chromatin modifications and the metabolo-epigenetic machinery itself are both amenable to modification by metformin in a local and a systemic manner. First, we consider the capacity of metformin to target global metabolic pathways or specific metabolic enzymes producing chromatin-modifying metabolites. Second, we examine its ability to directly or indirectly fine-tune the activation status of chromatin-modifying enzymes. Third, we envision how the interaction between metformin, diet and gut microbiota might systemically regulate the metabolic inputs to chromatin. Experimental and clinical validation of metformin's capacity to change the functional outcomes of the metabolo-epigenetic link could offer a proof-of-concept to therapeutically test the metabolic adjustability of the epigenomic landscape of cancer.
C1 [Cuyas, Elisabet; Verdura, Sara; Menendez, Javier A.] Girona Biomed Res Inst, Girona, Spain.
   [Cuyas, Elisabet; Verdura, Sara; Martin-Castillo, Begona; Menendez, Javier A.] Catalan Inst Oncol, Program Canc Therapeut Resistance ProCURE, Metab & Canc Grp, Girona, Spain.
   [Martin-Castillo, Begona] Catalan Inst Oncol, Unit Clin Res, Girona, Spain.
C3 Universitat de Girona; Girona University Hospital Dr. Josep Trueta;
   Institut d'Investigacio Biomedica de Girona (IDIBGI); Institut Catala
   d'Oncologia; Institut Catala d'Oncologia
RP Menendez, JA (通讯作者)，Girona Biomed Res Inst, Girona, Spain.; Menendez, JA (通讯作者)，Catalan Inst Oncol, Program Canc Therapeut Resistance ProCURE, Metab & Canc Grp, Girona, Spain.
EM jmenendez@idibgi.org
RI MENENDEZ, JAVIER A/C-6148-2016; Cuyas, Elisabet/G-8582-2018; verdura,
   Sara/AAC-3696-2022
OI MENENDEZ, JAVIER A/0000-0001-8733-4561; verdura,
   Sara/0000-0001-8980-0423; Martin-Castillo, Begona/0000-0001-8344-8174
FU Spanish Ministry of Science and Innovation [SAF2016-80639-P,
   PID2019-10455GB-I00]; Instituto de Salud Carlos III, Spanish Ministry of
   Science and Innovation (Spain) [CP20/00003]; Fundacio Oncolliga Girona
   (Lliga catalana d'ajuda al malalt de cancer, Girona)
FX Work in the Menendez laboratory is supported by the Spanish Ministry of
   Science and Innovation (grants SAF2016-80639-P and PID2019-10455GB-I00,
   Plan Nacional de l+D+I, founded by the European Regional Development
   Fund, Spain) and by an unrestricted research grant from the Fundacio
   Oncolliga Girona (Lliga catalana d'ajuda al malalt de cancer, Girona).
   EC is a recipient of a research contract "Miguel Servet" (CP20/00003)
   from the Instituto de Salud Carlos III, Spanish Ministry of Science and
   Innovation (Spain).
CR Alshawi A, 2019, J BIOL CHEM, V294, P2839, DOI 10.1074/jbc.RA118.006670
   Aroda VR, 2016, J CLIN ENDOCR METAB, V101, P1754, DOI 10.1210/jc.2015-3754
   Arpaia N, 2013, NATURE, V504, P451, DOI 10.1038/nature12726
   Baksh SC, 2021, TRENDS CELL BIOL, V31, P24, DOI 10.1016/j.tcb.2020.09.010
   Benjamin D, 2018, CELL REP, V25, P3047, DOI 10.1016/j.celrep.2018.11.043
   Benjamin JS, 2017, P NATL ACAD SCI USA, V114, P125, DOI 10.1073/pnas.1611431114
   Blacher E, 2019, NATURE, V572, P474, DOI 10.1038/s41586-019-1443-5
   Boon R, 2020, NAT METAB, V2, P1190, DOI 10.1038/s42255-020-00285-4
   Bose S, 2020, MOL CELL, V78, P1034, DOI 10.1016/j.molcel.2020.05.018
   Bridgeman SC, 2018, DIABETES OBES METAB, V20, P1553, DOI 10.1111/dom.13262
   Bridges HR, 2016, BMC BIOL, V14, DOI 10.1186/s12915-016-0287-9
   Bridges HR, 2014, BIOCHEM J, V462, P475, DOI 10.1042/BJ20140620
   Burgos-Barragan G, 2017, NATURE, V548, P549, DOI 10.1038/nature23481
   Cabreiro F, 2013, CELL, V153, P228, DOI 10.1016/j.cell.2013.02.035
   Canto C, 2009, NATURE, V458, P1056, DOI 10.1038/nature07813
   Chang PV, 2014, P NATL ACAD SCI USA, V111, P2247, DOI 10.1073/pnas.1322269111
   Chatterjee A, 2018, SEMIN CANCER BIOL, V51, P149, DOI 10.1016/j.semcancer.2017.08.004
   Corominas-Faja B, 2012, AGING-US, V4, P480, DOI 10.18632/aging.100472
   Cuyas E, 2018, ONCOGENE, V37, P963, DOI 10.1038/onc.2017.367
   Cuyas E, 2019, AGING-US, V11, P2874, DOI 10.18632/aging.101960
   Cuyas E, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00657
   Cuyas E, 2018, AGING CELL, V17, DOI 10.1111/acel.12772
   Dai ZW, 2020, NAT REV GENET, V21, P737, DOI 10.1038/s41576-020-0270-8
   Dai ZW, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-018-04426-y
   David LA, 2014, NATURE, V505, P559, DOI 10.1038/nature12820
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   den Besten G, 2013, J LIPID RES, V54, P2325, DOI 10.1194/jlr.R036012
   Di Francesco A, 2018, SCIENCE, V362, P770, DOI 10.1126/science.aau2095
   Donohoe DR, 2014, CANCER DISCOV, V4, P1387, DOI 10.1158/2159-8290.CD-14-0501
   Edrissi B, 2017, CHEM RES TOXICOL, V30, P1572, DOI 10.1021/acs.chemrestox.7b00075
   Edrissi B, 2013, PLOS GENET, V9, DOI 10.1371/journal.pgen.1003328
   Fellows R, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-017-02651-5
   Fiedler EC, 2018, CELL METAB, V28, P534, DOI 10.1016/j.cmet.2018.09.015
   Flavahan WA, 2017, SCIENCE, V357, DOI 10.1126/science.aal2380
   Galdieri L, 2016, J BIOL CHEM, V291, P25154, DOI 10.1074/jbc.M116.742247
   Gao X, 2019, NATURE, V572, P397, DOI 10.1038/s41586-019-1437-3
   Gao X, 2017, MOL ASPECTS MED, V54, P50, DOI 10.1016/j.mam.2016.09.001
   Gongol B, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19103238
   Gui DY, 2016, CELL METAB, V24, P716, DOI 10.1016/j.cmet.2016.09.006
   Hohnholt MC, 2017, J NEUROSCI RES, V95, P2307, DOI 10.1002/jnr.24050
   Jenkins Yonchu, 2014, BMC Res Notes, V7, P674, DOI 10.1186/1756-0500-7-674
   Johnson C, 2015, CANCER LETT, V356, P309, DOI 10.1016/j.canlet.2013.09.043
   Kender Z, 2014, EXP CLIN ENDOCR DIAB, V122, P316, DOI 10.1055/s-0034-1371818
   Kinsky OR, 2016, CHEM RES TOXICOL, V29, P227, DOI 10.1021/acs.chemrestox.5b00497
   Kulkarni AS, 2020, CELL METAB, V32, P15, DOI 10.1016/j.cmet.2020.04.001
   Li XY, 2019, NAT REV CLIN ONCOL, V16, P425, DOI 10.1038/s41571-019-0203-7
   Liu XJ, 2016, CELL METAB, V24, P728, DOI 10.1016/j.cmet.2016.09.005
   Madeo F, 2019, CELL METAB, V29, P592, DOI 10.1016/j.cmet.2019.01.018
   Mai XL, 2020, ENVIRON TOXICOL, V35, P1170, DOI 10.1002/tox.22982
   Marin TL, 2017, SCI SIGNAL, V10, DOI 10.1126/scisignal.aaf7478
   Meiser J, 2016, SCI ADV, V2, DOI 10.1126/sciadv.1601273
   Menendez JA, 2020, BIOMOLECULES, V10, DOI 10.3390/biom10050780
   Menendez JA, 2015, CURR PHARM DESIGN, V21, P3644, DOI 10.2174/1381612821666150710150327
   Menendez JA, 2014, FRONT ONCOL, V4, DOI 10.3389/fonc.2014.00262
   Mentch SJ, 2016, ANN NY ACAD SCI, V1363, P91, DOI 10.1111/nyas.12956
   Mentch SJ, 2015, CELL METAB, V22, P861, DOI 10.1016/j.cmet.2015.08.024
   Morris JP, 2019, NATURE, V573, P595, DOI 10.1038/s41586-019-1577-5
   Nebbioso A, 2018, PLOS GENET, V14, DOI 10.1371/journal.pgen.1007362
   Newman JC, 2014, TRENDS ENDOCRIN MET, V25, P42, DOI 10.1016/j.tem.2013.09.002
   Pietzke M, 2020, MOL METAB, V33, P23, DOI 10.1016/j.molmet.2019.05.012
   Pietzke M, 2019, CANCER METAB, V7, DOI 10.1186/s40170-019-0195-x
   Pontel LB, 2015, MOL CELL, V60, P177, DOI 10.1016/j.molcel.2015.08.020
   Price NL, 2012, CELL METAB, V15, P675, DOI 10.1016/j.cmet.2012.04.003
   Puchalska P, 2017, CELL METAB, V25, P262, DOI 10.1016/j.cmet.2016.12.022
   Rangan P, 2019, CELL REP, V26, P2704, DOI 10.1016/j.celrep.2019.02.019
   Reid MA, 2017, NAT CELL BIOL, V19, P1298, DOI 10.1038/ncb3629
   Romano KA, 2017, CELL HOST MICROBE, V22, P279, DOI 10.1016/j.chom.2017.07.021
   Rosario D, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.00775
   Salminen A, 2016, CELL SIGNAL, V28, P887, DOI 10.1016/j.cellsig.2016.03.009
   Salomon T, 2017, CELL CHEM BIOL, V24, P935, DOI 10.1016/j.chembiol.2017.07.012
   Sanderson SM, 2019, NAT REV CANCER, V19, P625, DOI 10.1038/s41568-019-0187-8
   Schuler KM, 2015, CANCER MED-US, V4, P161, DOI 10.1002/cam4.353
   Shimazu T, 2013, SCIENCE, V339, P211, DOI 10.1126/science.1227166
   Sleiman SF, 2016, ELIFE, V5, DOI 10.7554/eLife.15092
   Sonnet DS, 2016, SCI REP-UK, V6, DOI 10.1038/srep28775
   Tanaka Y, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-55075-0
   Tognini P, 2017, CELL METAB, V26, P523, DOI 10.1016/j.cmet.2017.08.015
   Verdura S, 2019, ONCOIMMUNOLOGY, V8, DOI 10.1080/2162402X.2019.1633235
   Wan LX, 2018, MOL CELL, V69, P279, DOI 10.1016/j.molcel.2017.12.024
   Wang TN, 2017, GENOME BIOL, V18, DOI 10.1186/s13059-017-1186-2
   Wang YP, 2018, CANCER COMMUN, V38, DOI 10.1186/s40880-018-0302-3
   Wu D, 2018, NATURE, V559, P637, DOI 10.1038/s41586-018-0350-5
   Wu P, 2019, FRONT PHARMACOL, V10, DOI 10.3389/fphar.2019.00143
   Xiao ZT, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-11738-0
   Xie ZY, 2016, MOL CELL, V62, P194, DOI 10.1016/j.molcel.2016.03.036
   Yang QY, 2016, CELL METAB, V24, P542, DOI 10.1016/j.cmet.2016.08.010
   Yerinde C, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.02718
   Yu XL, 2017, ONCOTARGET, V8, P5619, DOI 10.18632/oncotarget.13639
   Zhang XM, 2018, CELL MOL IMMUNOL, V15, P203, DOI 10.1038/cmi.2017.115
   Zheng QF, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-17066-y
   Zheng QF, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-09192-z
   Zhong T, 2017, ONCOGENE, V36, P2345, DOI 10.1038/onc.2016.391
NR 92
TC 3
Z9 3
U1 0
U2 8
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2234-943X
J9 FRONT ONCOL
JI Front. Oncol.
PD FEB 2
PY 2021
VL 10
AR 620641
DI 10.3389/fonc.2020.620641
PG 8
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA QH4BA
UT WOS:000618219400001
PM 33604300
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Shin, NR
   Gu, N
   Choi, HS
   Kim, H
AF Shin, Na Rae
   Gu, Namyi
   Choi, Han Seok
   Kim, Hojun
TI Combined effects of Scutellaria baicalensis with metformin on glucose
   tolerance of patients with type 2 diabetes via gut microbiota modulation
SO AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
LA English
DT Article
DE combination effect; gut microbiota; metformin; Scutellaria baicalensis;
   type 2 diabetes
ID SELENO-L-METHIONINE; COMBINATION THERAPY; OXIDATIVE STRESS; COMMUNITY;
   EXTRACT; RADIX; ACID
AB Metformin is a widely prescribed antidiabetic agent, whereas Scutellaria baicalensis (SB) is a commonly used medicinal herb for treatment of type 2 diabetes (T2D). Gut microbiota is involved in pathophysiology of metabolic diseases including T2D, and intestinal microbiota may be one of the important therapeutic targets for the ailment. This study was conducted to investigate the effects of SB combined with metformin on treatment of T2D while evaluating changes in the gut microbiota composition. Patients with T2D were randomized into control and treatment groups. Subjects who had already been prescribed metformin were allotted to additional SB (3.52 g/day) group or placebo group. The initial treatment session was 8 wk, and after washout period for 4 wk they were crossed over to the opposite treatment for another 8 wk. The influence of SB and placebo on the intestinal microbiota was analyzed by MiSeq system based on 16S rRNA gene. Glucose tolerance was lower in the SB group than the placebo group. Similarly, the relative RNA expression of TNF-alpha was significantly reduced after SB treatment. SB treatment influenced the gut microbiota, especially Lactobacillus and Akkermansia, which showed remarkable increases after SB treatment. Some subjects showed high liver enzyme levels after SB treatment, and their microbiota composition at baseline differed with subjects whose liver enzymes were not affected. We also predicted that selenocompound metabolism was increased and naphthalene degradation was decreased after SB treatment. These results suggest that SB with metformin treatment may improve the glucose tolerance and inflammation and influence the gut microbiota community in T2D.
C1 [Shin, Na Rae; Kim, Hojun] Dongguk Univ, Dept Rehabil Med Korean Med, 814 Siksa, Goyang, Gyeonggi Do, South Korea.
   [Gu, Namyi] Dongguk Univ, Clin Trial Ctr, Dept Clin Pharmacol & Therapeut, Coll Med, Goyang, Gyeonggi Do, South Korea.
   [Gu, Namyi] Ilsan Hosp, Goyang, Gyeonggi Do, South Korea.
   [Choi, Han Seok] Dongguk Univ, Dept Endocrinol, Goyang, Gyeonggi Do, South Korea.
C3 Dongguk University; Dongguk University; NHIS Ilsan Hospital; Dongguk
   University
RP Kim, H (通讯作者)，Dongguk Univ, Dept Rehabil Med Korean Med, 814 Siksa, Goyang, Gyeonggi Do, South Korea.
EM kimklar@gmail.com
OI Kim, Hojun/0000-0003-1038-0142
FU Convergence of Conventional Medicine and Traditional Korean Medicine
   Research and Development Program - Ministry of Health and Welfare
   through the Korea Health Industry Development Institute [HI14C0558]
FX This work was supported by a grant from the Convergence of Conventional
   Medicine and Traditional Korean Medicine Research and Development
   Program funded by the Ministry of Health and Welfare through the Korea
   Health Industry Development Institute (HI14C0558).
CR Bosi E, 2009, DIABETES OBES METAB, V11, P506, DOI 10.1111/j.1463-1326.2009.01040.x
   Caporaso JG, 2010, NAT METHODS, V7, P335, DOI 10.1038/nmeth.f.303
   Chen L, 2015, J FUNCT FOODS, V17, P892, DOI 10.1016/j.jff.2015.06.050
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Depommier C, 2019, NAT MED, V25, P1096, DOI 10.1038/s41591-019-0495-2
   Dujic T, 2016, DIABETIC MED, V33, P511, DOI 10.1111/dme.13040
   Ejtahed HS, 2011, J DAIRY SCI, V94, P3288, DOI 10.3168/jds.2010-4128
   Everard A, 2011, DIABETES, V60, P3307
   Flint HJ, 2012, NAT REV GASTRO HEPAT, V9, P577, DOI 10.1038/nrgastro.2012.156
   Fong SYK, 2015, J ETHNOPHARMACOL, V170, P106, DOI 10.1016/j.jep.2015.04.036
   Fonseca V, 2000, JAMA-J AM MED ASSOC, V283, P1695, DOI 10.1001/jama.283.13.1695
   Forslund K, 2017, NATURE, V545, P116, DOI 10.1038/nature22318
   Gao ZH, 2001, PHARMACOL RES, V43, P173, DOI 10.1006/phrs.2000.0761
   HAN ZP, 2017, PLOS ONE, V12
   Izzo AA, 2001, DRUGS, V61, P2163, DOI 10.2165/00003495-200161150-00002
   Jang I. S., 2007, J KOREAN ORIENTAL ME, V28, P1
   Jeon SM, 2016, EXP MOL MED, V48, DOI 10.1038/emm.2016.81
   Kim EH, 2009, J ETHNOPHARMACOL, V126, P320, DOI 10.1016/j.jep.2009.08.027
   Korea Food and Drug Administration, 2007, KOR PHARM
   Langille MGI, 2013, NAT BIOTECHNOL, V31, P814, DOI 10.1038/nbt.2676
   Lennicke C, 2017, BBA-GEN SUBJECTS, V1861, P3323, DOI 10.1016/j.bbagen.2016.08.015
   Moreau R, 2013, GASTROENTEROLOGY, V144, P1426, DOI 10.1053/j.gastro.2013.02.042
   Mutlu EA, 2012, AM J PHYSIOL-GASTR L, V302, pG966, DOI 10.1152/ajpgi.00380.2011
   Ohadoma SC, 2011, ASIAN PAC J TROP MED, V4, P475, DOI 10.1016/S1995-7645(11)60129-6
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Salpeter SR, 2010, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD002967.pub3
   Sathishkumar C, 2016, CLIN EPIGENETICS, V8, DOI 10.1186/s13148-016-0293-3
   Segata N, 2011, GENOME BIOL, V12, DOI 10.1186/gb-2011-12-6-r60
   Sender R, 2016, PLOS BIOL, V14, DOI 10.1371/journal.pbio.1002533
   Shimada Y, 2018, INTERNAL MED, V57, P1733, DOI 10.2169/internalmedicine.0275-17
   Shin NR, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.02271
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Song KH, 2013, PHYTOTHER RES, V27, P244, DOI 10.1002/ptr.4691
   Teo DCH, 2016, BMC COMPLEM ALTERN M, V16, DOI 10.1186/s12906-016-1168-z
   Ting RZW, 2006, ARCH INTERN MED, V166, P1975, DOI 10.1001/archinte.166.18.1975
   Tremaroli V, 2012, NATURE, V489, P242, DOI 10.1038/nature11552
   Tsai Franklin, 2009, Curr Gastroenterol Rep, V11, P307, DOI 10.1007/s11894-009-0045-z
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Ueno H, 2018, BIOL PHARM BULL, V41, P80, DOI 10.1248/bpb.b17-00603
   Ueno H, 2014, BIOL PHARM BULL, V37, P1569, DOI 10.1248/bpb.b14-00373
   Waisundara VY, 2008, AM J CHINESE MED, V36, P517, DOI 10.1142/S0192415X08005953
   Wang JH, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00620
   Wang JH, 2017, GENES-BASEL, V8, DOI 10.3390/genes8100239
   Yim S, 2017, XENOBIOTICA, V47, P998, DOI 10.1080/00498254.2016.1257836
   Yoon SB, 2009, J ETHNOPHARMACOL, V125, P286, DOI 10.1016/j.jep.2009.06.027
   Zhou GC, 2001, J CLIN INVEST, V108, P1167, DOI 10.1172/JCI200113505
NR 46
TC 19
Z9 19
U1 1
U2 21
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0193-1849
EI 1522-1555
J9 AM J PHYSIOL-ENDOC M
JI Am. J. Physiol.-Endocrinol. Metab.
PD JAN
PY 2020
VL 318
IS 1
BP E52
EP E61
DI 10.1152/ajpendo.00221.2019
PG 10
WC Endocrinology & Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Physiology
GA KE2UD
UT WOS:000508415100006
PM 31770016
OA Bronze
DA 2023-06-08
ER

PT J
AU Li, LY
   Abou-Samra, E
   Ning, ZB
   Zhang, X
   Mayne, J
   Wang, J
   Cheng, K
   Walker, K
   Stintzi, A
   Figeys, D
AF Li, Leyuan
   Abou-Samra, Elias
   Ning, Zhibin
   Zhang, Xu
   Mayne, Janice
   Wang, Janet
   Cheng, Kai
   Walker, Krystal
   Stintzi, Alain
   Figeys, Daniel
TI An in vitro model maintaining taxon-specific functional activities of
   the gut microbiome
SO NATURE COMMUNICATIONS
LA English
DT Article
ID INTESTINAL MICROBIOTA; BACTERIA; METAPROTEOMICS; STABILITY; METFORMIN;
   IMPACT; INFLAMMATION; ALTERS
AB In vitro gut microbiome models could provide timely and cost-efficient solutions to study microbiome responses to drugs. For this purpose, in vitro models that maintain the functional and compositional profiles of in vivo gut microbiomes would be extremely valuable. Here, we present a 96-deep well plate-based culturing model (MiPro) that maintains the functional and compositional profiles of individual gut microbiomes, as assessed by metaproteomics, while allowing a four-fold increase in viable bacteria counts. Comparison of taxon-specific functions between pre- and post-culture microbiomes shows a Pearson's correlation coefficient r of 0.83 +/- 0.03. In addition, we show a high degree of correlation between gut microbiome responses to metformin in the MiPro model and those in mice fed a high-fat diet. We propose MiPro as an in vitro gut microbiome model for scalable investigation of drug microbiome interactions such as during high-throughput drug screening.
C1 [Li, Leyuan; Abou-Samra, Elias; Ning, Zhibin; Zhang, Xu; Mayne, Janice; Cheng, Kai; Walker, Krystal; Stintzi, Alain; Figeys, Daniel] Univ Ottawa, Fac Med, Ottawa Inst Syst Biol, Dept Biochem Microbiol & Immunol, Ottawa, ON, Canada.
   [Wang, Janet] Univ Toronto, Fac Arts & Sci, Dept Stat Sci, Toronto, ON, Canada.
   [Figeys, Daniel] Canadian Inst Adv Res, Toronto, ON, Canada.
C3 University of Ottawa; University of Toronto; Canadian Institute for
   Advanced Research (CIFAR)
RP Figeys, D (通讯作者)，Univ Ottawa, Fac Med, Ottawa Inst Syst Biol, Dept Biochem Microbiol & Immunol, Ottawa, ON, Canada.; Figeys, D (通讯作者)，Canadian Inst Adv Res, Toronto, ON, Canada.
EM dfigeys@uottawa.ca
RI Leyuan, Li/AAJ-4305-2020
OI Leyuan, Li/0000-0003-2063-4441; Zhang, Xu/0000-0003-2406-9478
FU Government of Canada through Genome Canada; Ontario Genomics Institute
   [OGI-156, OGI-114]; CIHR [ECD-144627]; Natural Sciences and Engineering
   Research Council of Canada (NSERC) [210034]; Ontario Ministry of
   Economic Development and Innovation [REG1-4450]; Province of Ontario
   through the Ontario Research Fund [DIG-14405]
FX This work was supported by the Government of Canada through Genome
   Canada and the Ontario Genomics Institute (OGI-114), CIHR grant
   (ECD-144627), the Natural Sciences and Engineering Research Council of
   Canada (NSERC, grant no. 210034), and the Ontario Ministry of Economic
   Development and Innovation (REG1-4450). This work was also funded by the
   Government of Canada through Genome Canada and the Ontario Genomics
   Institute (OGI-156), as well as funding from the Province of Ontario
   through the Ontario Research Fund (DIG-14405). The authors thank Dr.
   James Butcher and Jennifer Li for the 16S rDNA sequencing contributing
   to the reviewing process, and thank Dr. Kendra Hodgkinson for
   proofreading.
CR AMSLER CD, 1993, J BACTERIOL, V175, P6238, DOI 10.1128/JB.175.19.6238-6244.1993
   Auchtung JM, 2015, MICROBIOME, V3, DOI 10.1186/s40168-015-0106-5
   Begley M, 2005, FEMS MICROBIOL REV, V29, P625, DOI 10.1016/j.femsre.2004.09.003
   Berney M, 2007, APPL ENVIRON MICROB, V73, P3283, DOI 10.1128/AEM.02750-06
   BONE E, 1976, AM J CLIN NUTR, V29, P1448, DOI 10.1093/ajcn/29.12.1448
   Cani PD, 2011, PHARMACOL THERAPEUT, V130, P202, DOI 10.1016/j.pharmthera.2011.01.012
   Cao HL, 2017, INT J CANCER, V140, P2545, DOI 10.1002/ijc.30643
   Charbonneau MR, 2016, CELL, V164, P859, DOI 10.1016/j.cell.2016.01.024
   Cheng K, 2017, MICROBIOME, V5, DOI 10.1186/s40168-017-0375-2
   Costello EK, 2012, SCIENCE, V336, P1255, DOI 10.1126/science.1224203
   Dao MC, 2016, GUT, V65, P426, DOI 10.1136/gutjnl-2014-308778
   David LA, 2014, NATURE, V505, P559, DOI 10.1038/nature12820
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Faith JJ, 2011, SCIENCE, V333, P101, DOI 10.1126/science.1206025
   GIBSON GR, 1994, FOOD MICROBIOL, V11, P491, DOI 10.1006/fmic.1994.1055
   Hooper LV, 2001, SCIENCE, V292, P1115, DOI 10.1126/science.1058709
   Human Microbiome Project Consortium, 2012, Nature, V486, P207, DOI 10.1038/nature11234
   Joly C, 2013, ENVIRON SCI POLLUT R, V20, P2726, DOI 10.1007/s11356-012-1283-4
   Kahrstrom CT, 2016, NATURE, V535, P47, DOI 10.1038/535047a
   Kim BS, 2011, J BIOMED BIOTECHNOL, DOI 10.1155/2011/838040
   Kim HJ, 2016, P NATL ACAD SCI USA, V113, pE7, DOI 10.1073/pnas.1522193112
   Kleiner M, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-01544-x
   Le Bastard Q, 2018, ALIMENT PHARM THER, V47, P332, DOI 10.1111/apt.14451
   Lee H, 2018, GERONTOLOGIST, V58, P159, DOI 10.1093/geront/gnx050
   Lesmes U, 2008, J AGR FOOD CHEM, V56, P5415, DOI 10.1021/jf800284d
   Li L, 2019, PREPRINT, DOI [10.1101/543256v1, DOI 10.1101/543256V1]
   Li LY, 2018, J PROTEOME RES, V17, P154, DOI 10.1021/acs.jproteome.7b00461
   Liao B, 2018, BIOINFORMATICS, V34, P3954, DOI 10.1093/bioinformatics/bty466
   Long WM, 2015, SCI REP-UK, V5, DOI 10.1038/srep13469
   Maccaferri S, 2010, J ANTIMICROB CHEMOTH, V65, P2556, DOI 10.1093/jac/dkq345
   Macfarlane GT, 1998, MICROB ECOL, V35, P180, DOI 10.1007/s002489900072
   Maier L, 2018, NATURE, V555, P623, DOI 10.1038/nature25979
   Maier L, 2017, CURR OPIN MICROBIOL, V39, P128, DOI 10.1016/j.mib.2017.11.001
   Mayers MD, 2017, J PROTEOME RES, V16, P1014, DOI 10.1021/acs.jproteome.6b00938
   McDonald JAK, 2013, J MICROBIOL METH, V95, P167, DOI 10.1016/j.mimet.2013.08.008
   Morgan AP, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0115225
   Moya A, 2016, TRENDS MICROBIOL, V24, P402, DOI 10.1016/j.tim.2016.02.002
   Olano-Martin E, 2000, BRIT J NUTR, V83, P247, DOI 10.1017/S0007114500000325
   Pimentel Mark, 2013, Curr Gastroenterol Rep, V15, P356, DOI 10.1007/s11894-013-0356-y
   Plovier H, 2017, NAT MED, V23, P107, DOI 10.1038/nm.4236
   Relman DA, 2012, NUTR REV, V70, pS2, DOI 10.1111/j.1753-4887.2012.00489.x
   Ridlon JM, 2006, J LIPID RES, V47, P241, DOI 10.1194/jlr.R500013-JLR200
   Rios-Covian D, 2016, FRONT MICROBIOL, V7, DOI 10.3389/fmicb.2016.00185
   Rycroft CE, 2001, J APPL MICROBIOL, V91, P878, DOI 10.1046/j.1365-2672.2001.01446.x
   Saulnier DMA, 2008, FEMS MICROBIOL ECOL, V66, P516, DOI 10.1111/j.1574-6941.2008.00561.x
   Shah P, 2016, NAT COMMUN, V7, DOI 10.1038/ncomms11535
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Sun Y, 2013, ADV APPL MICROBIOL, V85, P93, DOI 10.1016/B978-0-12-407672-3.00003-4
   Tanca A, 2017, MICROBIOME, V5, DOI 10.1186/s40168-017-0293-3
   Utzschneider KM, 2016, J CLIN ENDOCR METAB, V101, P2622, DOI 10.1210/jc.2015-4251
   Van den Abbeele P, 2013, ISME J, V7, P949, DOI 10.1038/ismej.2012.158
   Verberkmoes NC, 2009, ISME J, V3, P179, DOI 10.1038/ismej.2008.108
   VIDON N, 1988, DIABETES RES CLIN PR, V4, P223, DOI 10.1016/S0168-8227(88)80022-6
   Wang SP, 2016, ECOL LETT, V19, P510, DOI 10.1111/ele.12582
   Wilson ID, 2017, TRANSL RES, V179, P204, DOI 10.1016/j.trsl.2016.08.002
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Xu DB, 2014, GASTROENTEROLOGY, V146, P484, DOI 10.1053/j.gastro.2013.10.026
   Zhang X, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-018-05357-4
   Zhang X, 2018, J PROTEOMICS, V180, P120, DOI 10.1016/j.jprot.2017.07.001
   Zhang X, 2017, ANAL CHEM, V89, P9407, DOI 10.1021/acs.analchem.7b02224
   Zhang X, 2016, MICROBIOME, V4, DOI 10.1186/s40168-016-0176-z
   Zhang X, 2016, ANAL CHEM, V88, P6120, DOI 10.1021/acs.analchem.6b01412
   Zhang XQ, 2015, SCI REP-UK, V5, DOI 10.1038/srep10737
   Zhao LP, 2018, SCIENCE, V359, P1151, DOI 10.1126/science.aao5774
NR 64
TC 44
Z9 44
U1 6
U2 26
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
EI 2041-1723
J9 NAT COMMUN
JI Nat. Commun.
PD SEP 12
PY 2019
VL 10
AR 4146
DI 10.1038/s41467-019-12087-8
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA IW8BF
UT WOS:000485217200014
PM 31515476
OA Green Published, Green Submitted, gold
DA 2023-06-08
ER

PT J
AU Maniar, K
   Moideen, A
   Bhattacharyya, R
   Banerjee, D
AF Maniar, Kunal
   Moideen, Amal
   Bhattacharyya, Rajasri
   Banerjee, Dibyajyoti
TI Metformin exerts anti-obesity effect via gut microbiome modulation in
   prediabetics: A hypothesis
SO MEDICAL HYPOTHESES
LA English
DT Article
DE Prediabetes; Insulin; Metformin; Microbiome; Obesity; Butyrate-producing
   taxa
ID INSULIN CONCENTRATIONS; OBESE CHILDREN; WEIGHT; OVERWEIGHT; ADULTS;
   MAINTENANCE; PREVALENCE; SECRETION
AB Prediabetic individuals are characterized by high levels of insulin, an anabolic hormone having an important role in the maintenance of glucose homeostasis. However, insulin has also been found to increase the growth of certain bacteria which form the non-butyrate producing part of the gut microbiome. The gut microbiome is recently in focus for its strong association with many chronic diseases such as type 2 diabetes mellitus and obesity. Metformin, a widely popular anti-diabetic medication has been shown to prevent weight gain in many trials. There are many studies postulating the mechanisms of the anti-obesity effect of metformin including improvement in insulin sensitivity (and consequently a reduction in insulin levels). Recently, however, it is becoming evident that metformin's action is likely to be primarily mediated by the gut. Further, metformin has also shown to affect the growth characteristics of certain bacteria which form the part of the human gut microbiome. With this frame of reference in mind, we hypothesize that metformin is likely to exert its anti-obesity effect by altering the composition of the gut microbiome. If proved, this has the potential to contribute to the management of obesity and pave the way for the development of novel anti-obesity drugs. (C) 2017 Elsevier Ltd. All rights reserved.
C1 [Maniar, Kunal; Moideen, Amal] Post Grad Inst Med Educ & Res, Dept Pharmacol, Chandigarh, India.
   [Bhattacharyya, Rajasri; Banerjee, Dibyajyoti] Post Grad Inst Med Educ & Res, Dept Expt Med & Biotechnol, Res Block B,Sect 12, Chandigarh, India.
C3 Post Graduate Institute of Medical Education & Research (PGIMER),
   Chandigarh; Post Graduate Institute of Medical Education & Research
   (PGIMER), Chandigarh
RP Banerjee, D (通讯作者)，Post Grad Inst Med Educ & Res, Dept Expt Med & Biotechnol, Res Block B,Sect 12, Chandigarh, India.
EM dibyajyoti5200@yahoo.co.in
CR [Anonymous], 2000, Diabetes Care, V23, P1619
   Bailey CJ, 1996, NEW ENGL J MED, V334, P574, DOI 10.1056/NEJM199602293340906
   Bansal N, 2015, WORLD J DIABETES, V6, P296, DOI 10.4239/wjd.v6.i2.296
   BLACKARD WG, 1971, DIABETES, V20, P286, DOI 10.2337/diab.20.5.286
   BLACKARD WG, 1970, DIABETES, V19, P302, DOI 10.2337/diab.19.5.302
   Buse JB, 2016, DIABETES CARE, V39, P198, DOI 10.2337/dc15-0488
   Cabreiro F, 2013, CELL, V153, P228, DOI 10.1016/j.cell.2013.02.035
   Chakraborty S., 2016, INT J DRUG DEV RES, V8, P35
   Collado MC, 2008, AM J CLIN NUTR, V88, P894, DOI 10.1093/ajcn/88.4.894
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Dimitriadis G, 2011, DIABETES RES CLIN PR, V93, pS52, DOI 10.1016/S0168-8227(11)70014-6
   Duca FA, 2015, NAT MED, V21, P506, DOI 10.1038/nm.3787
   Eppinga RN, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0145719
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Gagnon J, 2013, DIABETES OBES METAB, V15, P276, DOI 10.1111/dom.12021
   Gao XL, 2015, BMC PEDIATR, V15, DOI 10.1186/s12887-015-0384-x
   Gao ZG, 2009, DIABETES, V58, P1509, DOI 10.2337/db08-1637
   Glueck CJ, 2001, METABOLISM, V50, P856, DOI 10.1053/meta.2001.24192
   Goitein D, 2016, SURG ENDOSC, V30, P273, DOI 10.1007/s00464-015-4205-y
   Gokcel A, 2002, DIABETES OBES METAB, V4, P49, DOI 10.1046/j.1463-1326.2002.00181.x
   Hammond RA, 2010, DIABETES METAB SYNDR, V3, P285, DOI [10.2147/DMSOTT.S7384, 10.2147/DMSO.S7384]
   Hurt Ryan T, 2010, Gastroenterol Hepatol (N Y), V6, P780
   James WPT, 2005, INT J OBES S7, V2008, pS120
   Kaur J, 2014, CARDIOL RES PRACT, V2014, DOI 10.1155/2014/943162
   Kendall D, 2013, J CLIN ENDOCR METAB, V98, P322, DOI 10.1210/jc.2012-2710
   Kim A, 2015, J CLIN GASTROENTEROL, V49, pS20, DOI 10.1097/MCG.0000000000000356
   Lambeth Stacey M, 2015, J Diabetes Obes, V2, P1
   LeBlanc ES, 2011, ANN INTERN MED, V155, P434, DOI 10.7326/0003-4819-155-7-201110040-00006
   Lee A, 1998, OBES RES, V6, P47, DOI 10.1002/j.1550-8528.1998.tb00314.x
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Levri KM, 2005, ANN FAM MED, V3, P457, DOI 10.1370/afm.343
   Ley RE, 2005, P NATL ACAD SCI USA, V102, P11070, DOI 10.1073/pnas.0504978102
   Lloyd-Price J, 2016, GENOME MED, V8, DOI 10.1186/s13073-016-0307-y
   Lo KA, 2013, CELL REP, V5, P259, DOI 10.1016/j.celrep.2013.08.039
   Lopetuso LR, 2013, GUT PATHOG, V5, DOI 10.1186/1757-4749-5-23
   Louis S, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0149564
   McCreight LJ, 2016, DIABETOLOGIA, V59, P426, DOI 10.1007/s00125-015-3844-9
   Mi YJ, 2015, AM J PREV MED, V49, P661, DOI 10.1016/j.amepre.2015.05.005
   Mulherin AJ, 2011, ENDOCRINOLOGY, V152, P4610, DOI 10.1210/en.2011-1485
   Must A, 2000, ENDOTEXT
   Pastor-Villaescusa B, 2016, TRIALS, V17, DOI 10.1186/s13063-016-1403-4
   Plotkin BJ, 2000, CURR MICROBIOL, V41, P60, DOI 10.1007/s002840010092
   Pradeepa R, 2015, INDIAN J MED RES, V142, P139, DOI 10.4103/0971-5916.164234
   Rhee SY, 2011, DIABETES METAB J, V35, P107, DOI 10.4093/dmj.2011.35.2.107
   Rodgers RJ, 2012, DIS MODEL MECH, V5, P621, DOI 10.1242/dmm.009621
   Rotroff DM, 2016, FRONT PHARMACOL, V7, DOI 10.3389/fphar.2016.00135
   Santacruz A, 2010, BRIT J NUTR, V104, P83, DOI 10.1017/S0007114510000176
   Shen J, 2013, MOL ASPECTS MED, V34, P39, DOI 10.1016/j.mam.2012.11.001
   Sussman JB, 2015, BMJ-BRIT MED J, V350, DOI 10.1136/bmj.h454
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Turner RC, 1998, LANCET, V352, P854, DOI 10.1016/s0140-6736(98)07037-8
   Vrieze A, 2012, GASTROENTEROLOGY, V143, P913, DOI 10.1053/j.gastro.2012.06.031
   Wing RR, 2006, NEW ENGL J MED, V355, P1563, DOI 10.1056/NEJMoa061883
   Yang Z, 2008, HEALTH SERV RES, V43, P849, DOI 10.1111/j.1475-6773.2007.00801.x
   Zhang XY, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0071108
   Zhang X, 2015, SCI REP-UK, V5, DOI 10.1038/srep14405
NR 56
TC 11
Z9 12
U1 0
U2 20
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PD JUL
PY 2017
VL 104
BP 117
EP 120
DI 10.1016/j.mehy.2017.06.001
PG 4
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA FB2KZ
UT WOS:000405974000028
PM 28673568
DA 2023-06-08
ER

PT J
AU Wu, TZ
   Horowitz, M
   Rayner, CK
AF Wu, Tongzhi
   Horowitz, Michael
   Rayner, Christopher K.
TI New insights into the anti-diabetic actions of metformin: from the liver
   to the gut
SO EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
LA English
DT Review
DE Metformin; hepatic glucose production; glucose absorption; incretin
   hormones; bile salt; gut microbiota
ID GLUCAGON-LIKE PEPTIDE-1; ACTIVATED PROTEIN-KINASE; HEPATIC
   GLUCONEOGENESIS; BILE-ACID; GLUCOSE-METABOLISM; TAUROCHOLIC ACID;
   INSULIN; SECRETION; RECEPTOR; BIGUANIDES
AB Introduction: Metformin is established as the first-line therapy for type 2 diabetes (T2DM), but its mode of action remains elusive. Elucidation of the mechanisms underlying the anti-diabetic action of metformin may have the potential to optimise its glucose-lowering efficacy and lead to the development of agents acting on novel targets for the management of type 2 diabetes.Areas covered: This review highlights key pharmacokinetic features of metformin, summarises recent insights into its hepatic and gastrointestinal actions relevant to blood glucose homeostasis, and discusses the common gastrointestinal side effects of metformin. Literature concerning these areas was reviewed on PubMed.Expert commentary: The mechanisms by which metformin improves glycaemic control in type 2 diabetes are complex. Although novel hepatic pathways continue to be reported in preclinical studies, there is a lack of human evidence for most of these. Considering the fundamental role of the gastrointestinal tract in the regulation of blood glucose homeostasis and pleiotropic actions of metformin on several gastrointestinal targets relevant to glycaemic control, the gut is likely to represent at least as important a site of metformin action as the liver in the management of type 2 diabetes.
C1 Univ Adelaide, Discipline Med, Adelaide, SA, Australia.
   Univ Adelaide, Ctr Res Excellence Translating Nutr Sci Good Hlth, Adelaide, SA, Australia.
C3 University of Adelaide; University of Adelaide
RP Wu, TZ (通讯作者)，Univ Adelaide, Royal Adelaide Hosp, Discipline Med, Level 6,Eleanor Harrald Bldg,North Terrace, Adelaide, SA 5000, Australia.
EM tongzhi.wu@adelaide.edu.au
RI horowitz, michael/HJY-3337-2023; Wu, Tongzhi/AAB-7343-2021; Horowitz,
   Michael/AAY-3397-2021
OI Horowitz, Michael/0000-0002-0942-0306; Wu, Tongzhi/0000-0003-1656-9210
CR Adrian TE, 2012, DIABETOLOGIA, V55, P2343, DOI 10.1007/s00125-012-2593-2
   Ali S, 2012, EXPERT OPIN PHARMACO, V13, P1797, DOI 10.1517/14656566.2012.705829
   Andujar-Plata P, 2012, DIABETES RES CLIN PR, V95, P1, DOI 10.1016/j.diabres.2011.09.022
   Bahne E, 2016, DIABETES OBES METAB, V18, P955, DOI 10.1111/dom.12697
   Bailey CJ, 2008, DIABETOLOGIA, V51, P1552, DOI 10.1007/s00125-008-1053-5
   BAILEY CJ, 1992, BRIT J PHARMACOL, V105, P1009, DOI 10.1111/j.1476-5381.1992.tb09093.x
   Brown JB, 2010, DIABETES CARE, V33, P501, DOI 10.2337/dc09-1749
   Buse JB, 2016, DIABETES CARE, V39, P198, DOI 10.2337/dc15-0488
   Bytzer P, 2001, ALIMENT PHARM THER, V15, P137, DOI 10.1046/j.1365-2036.2001.00896.x
   Cao J, 2014, J BIOL CHEM, V289, P20435, DOI 10.1074/jbc.M114.567271
   CASPARY WF, 1975, DIABETOLOGIA, V11, P113, DOI 10.1007/BF00429833
   Caton PW, 2010, J ENDOCRINOL, V205, P97, DOI 10.1677/JOE-09-0345
   Chandel NS, 2016, CELL METAB, V23, P569, DOI 10.1016/j.cmet.2016.03.010
   Ciaraldi TP, 2013, METABOLISM, V62, P1587, DOI 10.1016/j.metabol.2013.07.004
   Collado MC, 2007, APPL ENVIRON MICROB, V73, P7767, DOI 10.1128/AEM.01477-07
   Cuthbertson J, 2011, METABOLISM, V60, P52, DOI 10.1016/j.metabol.2010.01.001
   DeFronzo RA, 2016, DIABETOLOGIA, V59, P1645, DOI 10.1007/s00125-016-3992-6
   Duca FA, 2015, NAT MED, V21, P506, DOI 10.1038/nm.3787
   EISNER M, 1971, DIGESTION, V4, P309, DOI 10.1159/000197133
   EISSELE R, 1992, EUR J CLIN INVEST, V22, P283, DOI 10.1111/j.1365-2362.1992.tb01464.x
   El-Mir MY, 2000, J BIOL CHEM, V275, P223, DOI 10.1074/jbc.275.1.223
   Ferrannini E, 2015, DIABETES, V64, P3377, DOI 10.2337/db15-0214
   Foretz M, 2010, J CLIN INVEST, V120, P2355, DOI 10.1172/JCI40671
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Fullerton MD, 2013, NAT MED, V19, P1649, DOI 10.1038/nm.3372
   Gontier E, 2008, EUR J NUCL MED MOL I, V35, P95, DOI 10.1007/s00259-007-0563-6
   Graham GG, 2011, CLIN PHARMACOKINET, V50, P81, DOI 10.2165/11534750-000000000-00000
   Gu W, 2009, J PHARMACOL EXP THER, V331, P871, DOI 10.1124/jpet.109.157685
   Gunton JE, 2003, J CLIN ENDOCR METAB, V88, P1323, DOI 10.1210/jc.2002-021394
   Hansen M, 2015, DIABETOLOGIA, V58, pS110
   He L, 2015, CELL METAB, V21, P159, DOI 10.1016/j.cmet.2015.01.003
   He L, 2009, CELL, V137, P635, DOI 10.1016/j.cell.2009.03.016
   Hostalek U, 2015, DRUGS, V75, P1071, DOI 10.1007/s40265-015-0416-8
   Pham H, 2016, BIOCHEM BIOPH RES CO, V475, P295, DOI 10.1016/j.bbrc.2016.04.149
   Ikeda T, 2000, BIOCHEM PHARMACOL, V59, P887, DOI 10.1016/S0006-2952(99)00396-2
   Inzucchi SE, 2014, JAMA-J AM MED ASSOC, V312, P2668, DOI 10.1001/jama.2014.15298
   Islam KBMS, 2011, GASTROENTEROLOGY, V141, P1773, DOI 10.1053/j.gastro.2011.07.046
   Kim MH, 2014, J ENDOCRINOL, V220, P117, DOI 10.1530/JOE-13-0381
   Kojima S, 2012, BRIT J PHARMACOL, V167, P1362, DOI 10.1111/j.1476-5381.2012.02094.x
   Lenzen S, 1996, BIOCHEM PHARMACOL, V51, P893, DOI 10.1016/0006-2952(95)02243-0
   Luna V, 2006, DIABETOLOGIA, V49, P375, DOI 10.1007/s00125-005-0112-4
   Ma K, 2006, J CLIN INVEST, V116, P1102, DOI 10.1172/JCI25604
   Madiraju AK, 2014, NATURE, V510, P542, DOI 10.1038/nature13270
   Maida A, 2011, DIABETOLOGIA, V54, P339, DOI 10.1007/s00125-010-1937-z
   Miller RA, 2013, NATURE, V494, P256, DOI 10.1038/nature11808
   Morrissey KM, 2016, CLIN PHARMACOKINET, V55, P495, DOI 10.1007/s40262-015-0332-9
   Mulherin AJ, 2011, ENDOCRINOLOGY, V152, P4610, DOI 10.1210/en.2011-1485
   Nagpal R, 2016, BENEF MICROBES, V7, P181, DOI [10.3920/BM2015.0062, 10.3920/bm2015.0062]
   Naimi M, 2015, APPL PHYSIOL NUTR ME, V40, DOI 10.1139/apnm-2014-0430
   Natali A, 2004, DIABETES CARE, V27, P1349, DOI 10.2337/diacare.27.6.1349
   Nguyen A, 2008, CELL SIGNAL, V20, P2180, DOI 10.1016/j.cellsig.2008.06.014
   Oh J, 2016, DIABETES OBES METAB, V18, P104, DOI 10.1111/dom.12577
   Owen MR, 2000, BIOCHEM J, V348, P607, DOI 10.1042/0264-6021:3480607
   Phillips LK, 2015, NAT REV ENDOCRINOL, V11, P112, DOI 10.1038/nrendo.2014.202
   Pournaras DJ, 2012, ENDOCRINOLOGY, V153, P3613, DOI 10.1210/en.2011-2145
   Reimann F, 2008, CELL METAB, V8, P532, DOI 10.1016/j.cmet.2008.11.002
   Rudling M, 2015, BMC CARDIOVASC DISOR, V15, DOI 10.1186/s12872-015-0070-9
   Sakar Y, 2010, J PHYSIOL PHARMACOL, V61, P301
   Scarpello JHB, 1998, DIABETIC MED, V15, P651, DOI 10.1002/(SICI)1096-9136(199808)15:8<651::AID-DIA628>3.0.CO;2-A
   Selvin E, 2008, ARCH INTERN MED, V168, P2070, DOI 10.1001/archinte.168.19.2070
   Shaw RJ, 2005, SCIENCE, V310, P1642, DOI 10.1126/science.1120781
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Shu Y, 2007, J CLIN INVEST, V117, P1422, DOI 10.1172/JCI30558
   Slotta KH, 1929, BER DTSCH CHEM GES, V62, P1398, DOI 10.1002/cber.19290620605
   Sonne DP, 2015, DIABETES CARE, V38, pE215, DOI 10.2337/dc15-1794
   Sonne DP, 2013, AM J PHYSIOL-GASTR L, V304, pG413, DOI 10.1152/ajpgi.00435.2012
   Stepensky D, 2002, DRUG METAB DISPOS, V30, P861, DOI 10.1124/dmd.30.8.861
   STUMVOLL M, 1995, NEW ENGL J MED, V333, P550, DOI 10.1056/NEJM199508313330903
   SUM CF, 1992, DIABETIC MED, V9, P61, DOI 10.1111/j.1464-5491.1992.tb01716.x
   TUCKER GT, 1981, BRIT J CLIN PHARMACO, V12, P235
   Turner RC, 1998, LANCET, V352, P837, DOI 10.1016/s0140-6736(98)07019-6
   WILCOCK C, 1990, BIOCHEM PHARMACOL, V39, P1831, DOI 10.1016/0006-2952(90)90136-9
   WILCOCK C, 1991, J PHARM PHARMACOL, V43, P120, DOI 10.1111/j.2042-7158.1991.tb06645.x
   WILCOCK C, 1994, XENOBIOTICA, V24, P49, DOI 10.3109/00498259409043220
   Wu T, 2013, DIABETES OBES METAB, V15, P474, DOI 10.1111/dom.12043
   Wu TZ, 2017, DIABETES OBES METAB, V19, P290, DOI 10.1111/dom.12812
   Wu TZ, 2016, HANDB EXP PHARMACOL, V233, P137, DOI 10.1007/164_2015_9
   Wu TZ, 2014, DIABETES RES CLIN PR, V106, pE3, DOI 10.1016/j.diabres.2014.08.004
   Wu TZ, 2014, DIABETES, V63, P2776, DOI 10.2337/db13-1627
   Wu TZ, 2013, CURR OPIN PHARMACOL, V13, P928, DOI 10.1016/j.coph.2013.09.002
   Wu TZ, 2013, J CLIN ENDOCR METAB, V98, pE718, DOI 10.1210/jc.2012-3961
   Zhang CS, 2016, CELL METAB, V24, P521, DOI 10.1016/j.cmet.2016.09.003
   Zhang X, 2016, OBES SURG, V26, P1565, DOI 10.1007/s11695-015-1925-y
   Zhao WJ, 2016, CELL SIGNAL, V28, P1401, DOI 10.1016/j.cellsig.2016.06.018
   Zhou GC, 2001, J CLIN INVEST, V108, P1167, DOI 10.1172/JCI200113505
   Zhou KX, 2009, DIABETES, V58, P1434, DOI 10.2337/db08-0896
NR 86
TC 30
Z9 31
U1 2
U2 25
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1747-4124
EI 1747-4132
J9 EXPERT REV GASTROENT
JI Expert Rev. Gastroenterol. Hepatol.
PD FEB
PY 2017
VL 11
IS 2
BP 157
EP 166
DI 10.1080/17474124.2017.1273769
PG 10
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA EK2SM
UT WOS:000393777000008
PM 27983877
DA 2023-06-08
ER

PT J
AU Pircalabioru, GG
   Liaw, J
   Gundogdu, O
   Corcionivoschi, N
   Ilie, I
   Oprea, L
   Musat, M
   Chifiriuc, MC
AF Gradisteanu Pircalabioru, Gratiela
   Liaw, Janie
   Gundogdu, Ozan
   Corcionivoschi, Nicolae
   Ilie, Iuliana
   Oprea, Luciana
   Musat, Madalina
   Chifiriuc, Mariana-Carmen
TI Effects of the Lipid Profile, Type 2 Diabetes and Medication on the
   Metabolic Syndrome-Associated Gut Microbiome
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE metabolic syndrome; diabetes; microbiome; dysbiosis; metformin
ID AKKERMANSIA-MUCINIPHILA; INTESTINAL MICROBIOTA; INSULIN SENSITIVITY;
   GLUCOSE-METABOLISM; METFORMIN; OBESITY; DIVERSITY; DYSBIOSIS;
   INDIVIDUALS; IMPROVEMENT
AB Metabolic syndrome (MetSyn) is a major health problem affecting approximately 25% of the worldwide population. Since the gut microbiota is highly connected to the host metabolism, several recent studies have emerged to characterize the role of the microbiome in MetSyn development and progression. To this end, our study aimed to identify the microbiome patterns which distinguish MetSyn from type 2 diabetes mellitus (T2DM). We performed 16S rRNA amplicon sequencing on a cohort of 70 individuals among which 40 were MetSyn patients. The microbiome of MetSyn patients was characterised by reduced diversity, loss of butyrate producers (Subdoligranulum, Butyricicoccus, Faecalibacterium prausnitzii) and enrichment in the relative abundance of fungal populations. We also show a link between the gut microbiome and lipid metabolism in MetSyn. Specifically, low-density lipoproteins (LDL) and high-density lipoproteins (HDL) display a positive effect on gut microbial diversity. When interrogating the signature of gut microbiota in a subgroup of patients harbouring both MetSyn and T2DM conditions, we observed a significant increase in taxa such as Bacteroides, Clostridiales, and Erysipelotrichaceae. This preliminary study shows for the first time that T2DM brings unique signatures of gut microbiota in MetSyn patients. We also highlight the impact of metformin treatment on the gut microbiota. Metformin administration was linked to changes in Prevotellaceae, Rickenellaceae, and Clostridiales. Further research focusing on the microbiome-metabolome patterns is needed to clarify the exact association of various gut microbial communities with the progression of T2DM and the occurrence of various complications in MetSyn patients.
C1 [Gradisteanu Pircalabioru, Gratiela; Chifiriuc, Mariana-Carmen] Univ Bucharest ICUB, Res Inst, Bucharest 300645, Romania.
   [Liaw, Janie; Gundogdu, Ozan] London Sch Hyg & Trop Med, Fac Infect & Trop Dis, Keppel St, London WC1E 7HT, England.
   [Corcionivoschi, Nicolae] Agri Food & Biosci Inst, Bacteriol Branch, Vet Sci Div, Belfast BT9 5PX, Antrim, North Ireland.
   [Corcionivoschi, Nicolae] Banat Univ Agr Sci & Vet Med King Michael I Roman, Fac Bioengn Anim Resources, Timisoara 300645, Romania.
   [Ilie, Iuliana] Gral Med Clin, Bucharest 031424, Romania.
   [Oprea, Luciana; Musat, Madalina] Natl Inst Endocrinol CI Parhon, Bucharest 011863, Romania.
   [Musat, Madalina] Carol Davila Univ Med & Pharm, Dept Endocrinol, Bucharest 020021, Romania.
   [Chifiriuc, Mariana-Carmen] Romanian Acad, Bucharest 010071, Romania.
C3 University of London; London School of Hygiene & Tropical Medicine;
   Agri-Food & Biosciences Institute; Banat University of Agricultural
   Sciences & Veterinary Medicine; National Institute of Endocrinology C.I.
   Parhon; Carol Davila University of Medicine & Pharmacy; Romanian Academy
   of Sciences
RP Pircalabioru, GG (通讯作者)，Univ Bucharest ICUB, Res Inst, Bucharest 300645, Romania.; Gundogdu, O (通讯作者)，London Sch Hyg & Trop Med, Fac Infect & Trop Dis, Keppel St, London WC1E 7HT, England.
EM gratiela.gradisteanu@icub.unibuc.ro; janie.liaw@lshtm.ac.uk;
   ozan.gundogdu@lshtm.ac.uk; nicolae.corcionivoschi@afbini.gov.uk;
   ilieiu@yahoo.com; lucianaoprea92@yahoo.com; mdmusat@yahoo.com;
   carmen.chifiriuc@bio.unibuc.ro
RI Chifiriuc, Mariana Carmen/AFP-0825-2022; Gradisteanu,
   Gratiela/GYJ-6972-2022
OI Chifiriuc, Mariana Carmen/0000-0001-6098-1857; Gundogdu,
   Ozan/0000-0002-3550-0545; Oprea, Luciana/0000-0002-1200-9518;
   Corcionivoschi, Nicolae/0000-0002-3011-3108; Ilie,
   Iuliana/0000-0001-6659-3417
FU UEFISCDI [PN-III-P1-1.1-36PD-2019-0499, 224/2021, C1.2.PFE-CDI.2021-587]
FX This research was funded by UEFISCDI, project ID
   PN-III-P1-1.1-36PD-2019-0499, Grant number 224/2021 and
   C1.2.PFE-CDI.2021-587.
CR Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Bar N, 2020, NATURE, V588, P135, DOI 10.1038/s41586-020-2896-2
   Belzer C, 2012, ISME J, V6, P1449, DOI 10.1038/ismej.2012.6
   Bhute SS, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.00214
   Blandino G, 2016, DIABETES METAB, V42, P303, DOI 10.1016/j.diabet.2016.04.004
   Bolyen E, 2019, NAT BIOTECHNOL, V37, P852, DOI 10.1038/s41587-019-0209-9
   Bozkurt B, 2016, CIRCULATION, V134, pE535, DOI 10.1161/CIR.0000000000000450
   Chakravarthy SK, 2018, INDIAN J MICROBIOL, V58, P457, DOI 10.1007/s12088-018-0746-9
   Chen WG, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0039743
   CLARKE KR, 1993, MAR ECOL PROG SER, V92, P205, DOI 10.3354/meps092205
   Clemente JC, 2015, SCI ADV, V1, DOI 10.1126/sciadv.1500183
   Craven M, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0041594
   D'Amore R, 2016, BMC GENOMICS, V17, DOI 10.1186/s12864-015-2194-9
   Davies MJ, 2018, DIABETOLOGIA, V61, P2461, DOI [10.1007/s00125-018-4729-5, 10.2337/dci18-0033]
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Depommier C, 2019, NAT MED, V25, P1096, DOI 10.1038/s41591-019-0495-2
   Derrien M, 2017, MICROB PATHOGENESIS, V106, P171, DOI 10.1016/j.micpath.2016.02.005
   Deschasaux M, 2020, P NUTR SOC, V79, pE183, DOI 10.1017/S0029665120001317
   Diaz-Perdigones CM, 2022, BIOMED PHARMACOTHER, V145, DOI 10.1016/j.biopha.2021.112448
   Dray S, 2018, ADESPATIAL MULTIVARI
   Duncan SH, 2002, APPL ENVIRON MICROB, V68, P5186, DOI 10.1128/AEM.68.10.5186-5190.2002
   Fahed G, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23020786
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Fu JY, 2015, CIRC RES, V117, P817, DOI 10.1161/CIRCRESAHA.115.306807
   Fugmann M, 2015, SCI REP-UK, V5, DOI 10.1038/srep13212
   Ganesan K, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19123720
   Gao J, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-59235-5
   Cano PG, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0041079
   Gildner TE, 2020, EVOL MED PUBLIC HLTH, P45, DOI 10.1093/emph/eoaa007
   Graf J., 2014, PROKARYOTES, P857, DOI DOI 10.1007/978-3-642-38954-2_134
   Hippe B, 2016, BENEF MICROBES, V7, P511, DOI 10.3920/BM2015.0075
   Holmstrom K, 2004, ANAEROBE, V10, P197, DOI 10.1016/j.anaerobe.2004.01.004
   Ijaz UZ, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.02452
   Jain U, 2021, SCIENCE, V371, P1154, DOI 10.1126/science.abd0919
   Jones ML, 2012, EUR J CLIN NUTR, V66, P1234, DOI 10.1038/ejcn.2012.126
   Joshi N, 2011, SICKLE SLIDING WINDO
   Kaakoush NO, 2012, J CLIN MICROBIOL, V50, P3258, DOI 10.1128/JCM.01396-12
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kassambara A., 2018, MACHINE LEARNING ESS
   Katoh K, 2013, MOL BIOL EVOL, V30, P772, DOI 10.1093/molbev/mst010
   Kembel SW, 2010, BIOINFORMATICS, V26, P1463, DOI 10.1093/bioinformatics/btq166
   Khattab M.S.A., 2017, SCIENCE, V12, P47, DOI [10.3923/ijds.2017.47.51, DOI 10.3923/IJDS.2017.47.51]
   Kovatcheva-Datchary P, 2015, CELL METAB, V22, P971, DOI 10.1016/j.cmet.2015.10.001
   Kuhn M, 2008, J STAT SOFTW, V28, P1, DOI 10.18637/jss.v028.i05
   Lazar V, 2018, FRONT IMMUNOL, V9, DOI 10.3389/fimmu.2018.01830
   Le Chatelier E, 2013, NATURE, V500, P541, DOI 10.1038/nature12506
   Le Roy T, 2022, GUT, V71, P534, DOI 10.1136/gutjnl-2020-323778
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Legendre P, 2013, ECOL LETT, V16, P951, DOI 10.1111/ele.12141
   Leite AZ, 2017, FRONT IMMUNOL, V8, DOI 10.3389/fimmu.2017.01107
   Li J, 2017, MICROBIOME, V5, DOI 10.1186/s40168-016-0222-x
   Lin H, 2021, CIRC-HEART FAIL, V14, P1136, DOI 10.1161/CIRCHEARTFAILURE.120.008220
   Lippert K, 2017, BENEF MICROBES, V8, P545, DOI 10.3920/BM2016.0184
   Nguyen LN, 2011, J ANTIMICROB CHEMOTH, V66, P2573, DOI 10.1093/jac/dkr358
   Love MI, 2014, GENOME BIOL, V15, DOI 10.1186/s13059-014-0550-8
   Ludecke Daniel, 2018, Zenodo, V2.6.2
   Lumley T., 2009, **DATA OBJECT**
   Mao BY, 2018, NUTRIENTS, V10, DOI 10.3390/nu10081105
   Masella AP, 2012, BMC BIOINFORMATICS, V13, DOI 10.1186/1471-2105-13-31
   Mazidi M, 2016, DIABETES METAB SYND, V10, pS150, DOI 10.1016/j.dsx.2016.01.024
   McKenna A, 2020, MICROBIOME, V8, DOI 10.1186/s40168-020-00908-8
   McMurdie PJ, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0061217
   Michail S, 2012, INFLAMM BOWEL DIS, V18, P1799, DOI 10.1002/ibd.22860
   Michels N, 2022, OBES REV, V23, DOI 10.1111/obr.13409
   Mueller NT, 2021, DIABETES CARE, V44, P1462, DOI 10.2337/dc20-2257
   Munukka E, 2012, OBESITY, V20, P1082, DOI 10.1038/oby.2012.8
   Murphy R, 2017, OBES SURG, V27, P917, DOI 10.1007/s11695-016-2399-2
   Nakaya K, 2018, CURR OPIN LIPIDOL, V29, P18, DOI 10.1097/MOL.0000000000000472
   Nakayama J, 2015, SCI REP-UK, V5, DOI 10.1038/srep08397
   Nikolenko SI, 2013, BMC GENOMICS, V14, DOI 10.1186/1471-2164-14-S1-S7
   Oda E, 2018, CLIN DERMATOL, V36, P3, DOI 10.1016/j.clindermatol.2017.09.002
   Odamaki T, 2016, BMC MICROBIOL, V16, DOI 10.1186/s12866-016-0708-5
   Okeke Francis, 2014, Glob Adv Health Med, V3, P44, DOI 10.7453/gahmj.2014.018
   Oksanen J., 2022, PACKAGE VEGAN COMMUN, DOI DOI 10.4135/9781412971874.N145
   Ott SJ, 2004, GUT, V53, P685, DOI 10.1136/gut.2003.025403
   Ottman N, 2017, APPL ENVIRON MICROB, V83, DOI 10.1128/AEM.01014-17
   Pedersen HK, 2016, NATURE, V535, P376, DOI 10.1038/nature18646
   Pichler MJ, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-17075-x
   Pircalabioru G, 2016, CELL HOST MICROBE, V19, P651, DOI 10.1016/j.chom.2016.04.007
   Pircalabioru GG, 2022, METABOLITES, V12, DOI 10.3390/metabo12030218
   Price MN, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009490
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Qin Q, 2021, FRONT MICROBIOL, V12, DOI 10.3389/fmicb.2021.682721
   Quast C, 2013, NUCLEIC ACIDS RES, V41, pD590, DOI 10.1093/nar/gks1219
   Rognes T, 2016, PEERJ, V4, DOI 10.7717/peerj.2584
   Sheridan PO, 2016, MICROB GENOMICS, V2, DOI 10.1099/mgen.0.000043
   Shetty SA, 2017, FEMS MICROBIOL REV, V41, P182, DOI 10.1093/femsre/fuw045
   Singh R, 2021, J NEUROGASTROENTEROL, V27, P19, DOI 10.5056/jnm20149
   Sokol H, 2008, P NATL ACAD SCI USA, V105, P16731, DOI 10.1073/pnas.0804812105
   Sun L, 2019, FRONT MICROBIOL, V10, DOI 10.3389/fmicb.2019.01745
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Tang RQ, 2018, UROLITHIASIS, V46, P503, DOI 10.1007/s00240-018-1037-y
   Taylor M., 2014, SINKR COLLECTION FUN
   Tomizawa H., 2021, J HYPERTENS, V10, P1
   Turnbaugh PJ, 2008, CELL HOST MICROBE, V3, P213, DOI 10.1016/j.chom.2008.02.015
   Vallianou NG, 2019, HORM-INT J ENDOCRINO, V18, P141, DOI 10.1007/s42000-019-00093-w
   Van Hul M, 2020, GUT MICROBES, V12, P1, DOI 10.1080/19490976.2020.1849998
   Vojinovic D, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-13721-1
   Vrieze A, 2012, GASTROENTEROLOGY, V143, P913, DOI 10.1053/j.gastro.2012.06.031
   Wang PX, 2020, CHINESE MED J-PEKING, V133, P808, DOI 10.1097/CM9.0000000000000696
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Yamaguchi Y, 2016, DIGESTION, V94, P66, DOI 10.1159/000447690
   Yang JY, 2017, MUCOSAL IMMUNOL, V10, P104, DOI 10.1038/mi.2016.42
   Yassour M, 2016, GENOME MED, V8, DOI 10.1186/s13073-016-0271-6
   Zhang HS, 2009, P NATL ACAD SCI USA, V106, P2365, DOI 10.1073/pnas.0812600106
   Zhang XY, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0071108
   Zhou Q, 2021, DIABET METAB SYND OB, V14, P2177, DOI 10.2147/DMSO.S311388
   Zuo T, 2021, GENOM PROTEOM BIOINF, V19, P679, DOI 10.1016/j.gpb.2021.09.004
NR 108
TC 4
Z9 4
U1 2
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JUL
PY 2022
VL 23
IS 14
AR 7509
DI 10.3390/ijms23147509
PG 21
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 3H2LQ
UT WOS:000831872000001
PM 35886861
OA gold, Green Accepted, Green Published
DA 2023-06-08
ER

PT J
AU Malik, F
   Mehdi, SF
   Ali, H
   Patel, P
   Basharat, A
   Kumar, A
   Ashok, F
   Stein, J
   Brima, W
   Malhotra, P
   Roth, J
AF Malik, Faiza
   Mehdi, Syed Faizan
   Ali, Haroon
   Patel, Priya
   Basharat, Anam
   Kumar, Amrat
   Ashok, Fnu
   Stein, Joanna
   Brima, Wunnie
   Malhotra, Prashant
   Roth, Jesse
TI Is metformin poised for a second career as an antimicrobial?
SO DIABETES-METABOLISM RESEARCH AND REVIEWS
LA English
DT Review
DE antimicrobial; hepatitis B; metformin; sepsis; Trypanosomiasis cruzi;
   tuberculosis
ID CHAIN FATTY-ACIDS; HIV-INFECTED PATIENTS; LACTIC-ACIDOSIS;
   DIABETIC-PATIENTS; HEPATITIS-C; AKKERMANSIA-MUCINIPHILA;
   CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION; PROGNOSTIC VALUE; GUT
   MICROBIOTA
AB Metformin, a widely used antihyperglycaemic, has a good safety profile, reasonably manageable side-effects, is inexpensive, and causes a desirable amount of weight loss. In 4 studies of patients with tuberculosis (1 prospective and 3 retrospective), metformin administration resulted in better outcomes. In mice with several models of endotoxemia, metformin diminished levels of proinflammatory cytokines and improved survival. Laboratory studies showed effectiveness of the drug on multiple pathogens, including Trichinella spiralis, Staphylococcus aureus, Pseudomonas aeruginosa, hepatitis B virus, hepatitis C virus, and human immunodeficiency virus. Metformin administration in humans and mice produced major changes in the composition of the gut microbiota. These recently discovered microbe-modulating properties of the drug have led investigators to predict wide therapeutic utility for metformin. The recent easing in United States Food and Drug Administration (FDA) guidelines regarding administration of metformin to patients with kidney disease, and reduced anxiety about patient safety in terms of lactic acidosis, increase the probability of broadening of metformin's usage as a treatment of infectious agents. In this text we review articles pertinent to metformin's effects on microorganisms, both pathogens and commensals. We highlight the possible role of metformin in a wide range of infectious diseases and a possible expansion of its therapeutic profile in this field. A systematic review was done of PubMed indexed articles that examined the effects of metformin on a wide range of pathogens. Metformin was found to have efficacy as an antimicrobial agent in patients with tuberculosis. Mice infected with Trypanosomiasis cruzi had higher survival when also treated with metformin. The drug in vitro was active against T.spiralis, S.aureus, P.aeruginosa, and hepatitis B virus. In addition there is emerging literature on its role in sepsis. We conclude that metformin may have a potential role in the therapy for multiple infectious diseases. Metformin, in addition to its traditional effects on glucose metabolism, provides anti-microbial benefits in patients with tuberculosis and in a very wide range of other infections encounters in vitro and in vivo.
C1 [Malik, Faiza; Mehdi, Syed Faizan; Ali, Haroon; Patel, Priya; Basharat, Anam; Kumar, Amrat; Ashok, Fnu; Stein, Joanna; Brima, Wunnie; Roth, Jesse] Northwell Hlth, Feinstein Inst Med Res, Lab Diabet & Diabet Related Res, Manhasset, NY USA.
   [Malhotra, Prashant] Hofstra Northwell, Donald & Barbara Zucker Sch Med, Div Infect Dis, Manhasset, NY USA.
   [Stein, Joanna; Malhotra, Prashant; Roth, Jesse] Hofstra Northwell, Donald & Barbara Zucker Sch Med, Manhasset, NY USA.
C3 Northwell Health; Northwell Health; Northwell Health
RP Malik, F; Roth, J (通讯作者)，Feinstein Inst Med Res, Lab Diabet & Diabet Related Disorders, 350 Community Dr, Manhasset, NY 11030 USA.
EM faiza.s.malik@hotmail.com; jesserothmd@hotmail.com
OI Malhotra, Prashant/0000-0001-8413-7423
FU Feinstein Institute for Medical Research of the Northwell Health System;
   Alan and Tatyana Forman Family; Russell Berrie Foundation; National
   Heart, Lung and Blood Institute [HL-112099]
FX Feinstein Institute for Medical Research of the Northwell Health System;
   Alan and Tatyana Forman Family; Russell Berrie Foundation; National
   Heart, Lung and Blood Institute, Grant/Award Number: HL-112099
CR Alkhalil Chadi, 2002, International Urology and Nephrology, V34, P419, DOI 10.1023/A:1024456402584
   BAILEY CJ, 1994, BRIT J PHARMACOL, V112, P671, DOI 10.1111/j.1476-5381.1994.tb13128.x
   BAILEY CJ, 1992, DIABETES CARE, V15, P755, DOI 10.2337/diacare.15.6.755
   Bailey CJ, 1996, NEW ENGL J MED, V334, P574, DOI 10.1056/NEJM199602293340906
   Baker EH, 2006, THORAX, V61, P284, DOI 10.1136/thx.2005.051029
   Baker EH, 2007, J APPL PHYSIOL, V102, P1969, DOI 10.1152/japplphysiol.01425.2006
   Bergheim I, 2006, J PHARMACOL EXP THER, V316, P1053, DOI 10.1124/jpet.105.092122
   Bodmer M, 2008, DIABETES CARE, V31, P2086, DOI 10.2337/dc08-1171
   BONORA E, 1984, CURR MED RES OPIN, V9, P47, DOI 10.1185/03007998409109558
   Bridges HR, 2014, BIOCHEM J, V462, P475, DOI 10.1042/BJ20140620
   Brima W, 2015, DIABETES-METAB RES, V31, P346, DOI 10.1002/dmrr.2636
   Brown JB, 1998, DIABETES CARE, V21, P1659, DOI 10.2337/diacare.21.10.1659
   Buse JB, 2016, DIABETES CARE, V39, P198, DOI 10.2337/dc15-0488
   Calabrese AT, 2002, ARCH INTERN MED, V162, P434, DOI 10.1001/archinte.162.4.434
   Cameron AR, 2016, CIRC RES, V119, P652, DOI 10.1161/CIRCRESAHA.116.308445
   Chen CI, 2015, MEDICINE, V94, DOI 10.1097/MD.0000000000000462
   Ching C. K., 2008, Hong Kong Medical Journal, V14, P50
   Connolly V, 1996, POSTGRAD MED J, V72, P352, DOI 10.1136/pgmj.72.848.352
   Crowley MJ, 2017, ANN INTERN MED, V166, P191, DOI 10.7326/M16-1901
   Currier JS, 2003, JAIDS-J ACQ IMM DEF, V33, P506, DOI 10.1097/00126334-200308010-00012
   Dao MC, 2016, GUT, V65, P426, DOI 10.1136/gutjnl-2014-308778
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   De Vadder F, 2014, CELL, V156, P84, DOI 10.1016/j.cell.2013.12.016
   DeFronzo RA, 2016, DIABETOLOGIA, V59, P1645, DOI 10.1007/s00125-016-3992-6
   Degner NR, 2018, CLIN INFECT DIS, V66, P198, DOI 10.1093/cid/cix819
   Doenyas-Barak K, 2016, CRIT CARE, V20, DOI 10.1186/s13054-015-1180-6
   Ekstrom N, 2012, BMJ OPEN, V2, DOI 10.1136/bmjopen-2012-001076
   Emslie-Smith AM, 2001, DIABETIC MED, V18, P483, DOI 10.1046/j.1464-5491.2001.00509.x
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Fitch K, 2012, AIDS, V26, P587, DOI 10.1097/QAD.0b013e32834f33cc
   Foretz M, 2010, J CLIN INVEST, V120, P2355, DOI 10.1172/JCI40671
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Freiberg MS, 2013, JAMA INTERN MED, V173, P614, DOI 10.1001/jamainternmed.2013.3728
   Fukuda S, 2011, NATURE, V469, P543, DOI 10.1038/nature09646
   Gargari G, 2016, APPL ENVIRON MICROB, V82, P5850, DOI 10.1128/AEM.01753-16
   Garnett JP, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0076283
   Garnett JP, 2013, THORAX, V68, P835, DOI 10.1136/thoraxjnl-2012-203178
   Gill SK, 2016, SCI REP-UK, V6, DOI 10.1038/srep27636
   Green JP, 2012, AM J EMERG MED, V30, P1667, DOI 10.1016/j.ajem.2012.01.014
   Holstein A, 1999, DIABETIC MED, V16, P692, DOI 10.1046/j.1464-5491.1999.00115.x
   Horlen C, 2002, JAMA-J AM MED ASSOC, V287, P2504, DOI 10.1001/jama.287.19.2504-a
   Hotchkiss RS, 2013, NAT REV IMMUNOL, V13, P862, DOI 10.1038/nri3552
   Hsu CS, 2014, J FORMOS MED ASSOC, V113, P716, DOI 10.1016/j.jfma.2014.05.007
   Kamber N, 2008, MED J AUSTRALIA, V188, P446, DOI 10.5694/j.1326-5377.2008.tb01713.x
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kelly CJ, 2015, CELL HOST MICROBE, V17, P662, DOI 10.1016/j.chom.2015.03.005
   Kennedy L, 2005, DIABETES CARE, V28, P922, DOI 10.2337/diacare.28.4.922
   Kim J, 2014, J BIOL CHEM, V289, P23246, DOI 10.1074/jbc.M114.577908
   Koh A, 2016, CELL, V165, P1332, DOI 10.1016/j.cell.2016.05.041
   Koren S, 2017, ISR MED ASSOC J, V19, P300
   Kostic AD, 2013, CELL HOST MICROBE, V14, P207, DOI 10.1016/j.chom.2013.07.007
   Lai SW, 2012, AM J GASTROENTEROL, V107, P46, DOI 10.1038/ajg.2011.384
   Lalau JD, 1999, DRUG SAFETY, V20, P377, DOI 10.2165/00002018-199920040-00006
   LALAU JD, 1995, DIABETES CARE, V18, P779, DOI 10.2337/diacare.18.6.779
   Lang S, 2010, AIDS, V24, P1228, DOI 10.1097/QAD.0b013e328339192f
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Lim VCC, 2007, INT J CLIN PRACT, V61, P1829, DOI 10.1111/j.1742-1241.2007.01487.x
   Liu G, 2017, INT IMMUNOPHARMACOL, V47, P166, DOI 10.1016/j.intimp.2017.04.002
   Madiraju AK, 2014, NATURE, V510, P542, DOI 10.1038/nature13270
   Maeurer M, 2014, SCI TRANSL MED, V6, DOI 10.1126/scitranslmed.aaa1274
   Mardinoglu A, 2016, CELL METAB, V23, P10, DOI 10.1016/j.cmet.2015.12.012
   Martin GS, 2003, NEW ENGL J MED, V348, P1546, DOI 10.1056/NEJMoa022139
   Marupuru S, 2017, BRAZ J INFECT DIS, V21, P312, DOI 10.1016/j.bjid.2017.01.001
   Mikkelsen ME, 2009, CRIT CARE MED, V37, P1670, DOI 10.1097/CCM.0b013e31819fcf68
   Negrotto L, 2016, JAMA NEUROL, V73, P520, DOI 10.1001/jamaneurol.2015.4807
   Nkontchou G, 2011, J CLIN ENDOCR METAB, V96, P2601, DOI 10.1210/jc.2010-2415
   Nou E, 2016, LANCET DIABETES ENDO, V4, P598, DOI 10.1016/S2213-8587(15)00388-5
   Obel N, 2007, CLIN INFECT DIS, V44, P1625, DOI 10.1086/518285
   Othman AA, 2016, PARASITOL INT, V65, P105, DOI 10.1016/j.parint.2015.11.001
   Owen MR, 2000, BIOCHEM J, V348, P607, DOI 10.1042/0264-6021:3480607
   Paisible AL, 2015, JAIDS-J ACQ IMM DEF, V68, P209, DOI 10.1097/QAI.0000000000000419
   Park J, 2017, SHOCK, V47, P582, DOI 10.1097/SHK.0000000000000782
   Patkee WRA, 2016, J CELL MOL MED, V20, P758, DOI 10.1111/jcmm.12784
   Pezzulo AA, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0016166
   Philips BJ, 2005, THORAX, V60, P761, DOI 10.1136/thx.2004.035766
   Plovier H, 2017, NAT MED, V23, P107, DOI 10.1038/nm.4236
   Pollak M, 2017, DIABETOLOGIA, V60, P1662, DOI 10.1007/s00125-017-4352-x
   Preiss D, 2017, DIABETES OBES METAB, V19, P356, DOI 10.1111/dom.12826
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Rachmani Rita, 2002, Eur J Intern Med, V13, P428, DOI 10.1016/S0953-6205(02)00131-0
   Rayasaml GV, 2015, TRENDS PHARMACOL SCI, V36, P506, DOI 10.1016/j.tips.2015.05.005
   Rena G, 2017, DIABETOLOGIA, V60, P1577, DOI 10.1007/s00125-017-4342-z
   Ridlon JM, 2016, GUT MICROBES, V7, P22, DOI 10.1080/19490976.2015.1127483
   Romero-Gomez M, 2009, HEPATOLOGY, V50, P1702, DOI 10.1002/hep.23206
   Roussel R, 2010, ARCH INTERN MED, V170, P1892, DOI 10.1001/archinternmed.2010.409
   Sakon H, 2008, INT J SYST EVOL MICR, V58, P970, DOI 10.1099/ijs.0.65456-0
   Salpeter SR, 2010, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD002967.pub3
   Scarpello JHB, 1998, DIABETIC MED, V15, P651, DOI 10.1002/(SICI)1096-9136(199808)15:8<651::AID-DIA628>3.0.CO;2-A
   SCHAFER G, 1983, DIABETES METAB, V9, P148
   Scher JU, 2013, ELIFE, V2, DOI 10.7554/eLife.01202
   Sharifi Amir Houshang, 2014, Middle East J Dig Dis, V6, P13
   Shaw RJ, 2005, SCIENCE, V310, P1642, DOI 10.1126/science.1120781
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Singhal A, 2014, SCI TRANSL MED, V6, DOI 10.1126/scitranslmed.3009885
   Sleeth ML, 2010, NUTR RES REV, V23, P135, DOI 10.1017/S0954422410000089
   Stades AME, 2004, J INTERN MED, V255, P179, DOI 10.1046/j.1365-2796.2003.01271.x
   Stepensky D, 2002, DRUG METAB DISPOS, V30, P861, DOI 10.1124/dmd.30.8.861
   Tamer A, 2006, JPN J INFECT DIS, V59, P10
   Tang WHW, 2013, NEW ENGL J MED, V368, P1575, DOI 10.1056/NEJMoa1109400
   Triant VA, 2007, J CLIN ENDOCR METAB, V92, P2506, DOI 10.1210/jc.2006-2190
   Tsoyi K, 2011, BRIT J PHARMACOL, V162, P1498, DOI 10.1111/j.1476-5381.2010.01126.x
   Vashisht R, 2015, J TRANSL MED, V13, DOI 10.1186/s12967-015-0443-y
   Wang ZN, 2011, NATURE, V472, P57, DOI 10.1038/nature09922
   Wong JMW, 2006, J CLIN GASTROENTEROL, V40, P235, DOI 10.1097/00004836-200603000-00015
   Wu GD, 2011, SCIENCE, V334, P105, DOI 10.1126/science.1208344
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Wu L, 2015, SCI REP-UK, V5, DOI 10.1038/srep10147
   Wu SG, 2009, NAT MED, V15, P1016, DOI 10.1038/nm.2015
   Xue YS, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0168670
   Xun YH, 2014, J VIRAL HEPATITIS, V21, P597, DOI 10.1111/jvh.12187
   Yi FH, 2008, ENDOCRINOLOGY, V149, P2341, DOI 10.1210/en.2007-1142
   Yu JW, 2012, INT J INFECT DIS, V16, pE436, DOI 10.1016/j.ijid.2012.02.004
   Zhang CS, 2016, CELL METAB, V24, P521, DOI 10.1016/j.cmet.2016.09.003
   Zhang X., 2015, SCI REP UK, V5
   Zhang ZJ, 2014, AM J EPIDEMIOL, V180, P11, DOI 10.1093/aje/kwu124
   Zhou GC, 2001, J CLIN INVEST, V108, P1167, DOI 10.1172/JCI200113505
   Zhou ZY, 2016, ACTA PHARMACOL SIN, V37, P1063, DOI 10.1038/aps.2016.21
NR 118
TC 55
Z9 60
U1 1
U2 28
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1520-7552
EI 1520-7560
J9 DIABETES-METAB RES
JI Diabetes-Metab. Res. Rev.
PD MAY
PY 2018
VL 34
IS 4
AR e2975
DI 10.1002/dmrr.2975
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA GF5DA
UT WOS:000431984700001
PM 29271563
OA Bronze
DA 2023-06-08
ER

PT J
AU Yang, JQ
   Zhang, ZY
   Xie, ZR
   Bai, L
   Xiong, P
   Chen, FR
   Zhu, TL
   Peng, QY
   Wu, HJ
   Zhou, Y
   Ma, YR
   Zhang, YJ
   Chen, MH
   Gao, JY
   Tian, WW
   Shi, K
   Du, Y
   Duan, Y
   Wang, HW
   Xu, Y
   Kuang, YQ
   Zhu, M
   Yu, JH
   Wang, KH
AF Yang, Jiqing
   Zhang, Zunyue
   Xie, Zhenrong
   Bai, Ling
   Xiong, Pu
   Chen, Fengrong
   Zhu, Tailin
   Peng, Qingyan
   Wu, Hongjin
   Zhou, Yong
   Ma, Yuru
   Zhang, Yongjin
   Chen, Minghui
   Gao, Jianyuan
   Tian, Weiwei
   Shi, Kai
   Du, Yan
   Duan, Yong
   Wang, Huawei
   Xu, Yu
   Kuang, Yi-Qun
   Zhu, Mei
   Yu, Juehua
   Wang, Kunhua
TI Metformin modulates microbiota-derived inosine and ameliorates
   methamphetamine-induced anxiety and depression-like withdrawal symptoms
   in mice
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Methamphetamine; Withdrawal; Gut microbiota; Metformin; Inosine
ID GUT MICROBIOTA; MODEL; DISORDERS; RESPONSES; PATHWAY; HARMS; SEX
AB Background: Metformin exhibits therapeutic potential in behavioural deficits induced by methamphetamine (METH) in rats. Emerging studies suggest gut microbiota may impact psychiatric symptoms, but there is no direct evidence supporting metformin's participation in the pathophysiology of withdrawal symptoms via modulation of gut microbiota. Methods: In order to define the functional impacts of gut microbiota and metformin to the behavioural deficits during METH withdrawal, we utilized a combination of fecal microbiota transplantation (FMT), high-throughput sequencing, and untargeted metabolomics technologies. Results: First, METH addicts exhibited higher alpha diversity and distinct microbial structures compared to healthy controls. In particular, the relative abundance of Rikenellaceae was positively correlated with the severity of anxiety and depression. Second, both human-to-mouse and mouse-to-mouse FMTs confirmed that METH-alteredmicrobiota transplantation is sufficient to promote anxiety and depression-like behaviours in recipient germ-free mice, and these behavioural disturbances could be ameliorated by metformin. In-depth analysis revealed that METH significantly altered the bacterial composition and structure as well as relative abundance of several bacterial taxa and metabolites, including Rikenellaceae and inosine, respectively, whereas add-on metformin could remodel these alterations. Finally, the inosine complementation successfully restored METH-induced anxiety and depression-like behaviours in mice. Conclusion: This study demonstrates that METH withdrawal-induced anxiety and depression-like behaviours are reversible and transmissible via gut microbiota in a mouse model. The therapeutic effects of metformin on psychiatric manifestations are associated with microbiota-derived metabolites, highlighting the role of the gut microbiota in substance use disorders and the pathophysiology of withdrawal symptoms.
C1 [Yang, Jiqing; Zhang, Zunyue; Xie, Zhenrong; Xiong, Pu; Chen, Fengrong; Peng, Qingyan; Wu, Hongjin; Zhou, Yong; Ma, Yuru; Zhang, Yongjin; Chen, Minghui; Gao, Jianyuan; Tian, Weiwei; Wang, Huawei; Xu, Yu; Kuang, Yi-Qun; Zhu, Mei; Yu, Juehua; Wang, Kunhua] Kunming Med Univ, NHC Key Lab Drug Addict Med, Affiliated Hosp 1, Kunming 650032, Peoples R China.
   [Yang, Jiqing; Du, Yan; Duan, Yong] Kunming Med Univ, Dept Clin Lab, Affiliated Hosp 1, Kunming 650032, Peoples R China.
   [Yang, Jiqing; Bai, Ling; Wang, Kunhua] Kunming Univ Sci & Technol, Fac Life Sci & Technol, Kunming 650500, Peoples R China.
   [Yang, Jiqing; Xie, Zhenrong; Xiong, Pu; Chen, Fengrong; Peng, Qingyan; Wu, Hongjin; Zhou, Yong; Ma, Yuru; Zhang, Yongjin; Chen, Minghui; Gao, Jianyuan; Kuang, Yi-Qun; Zhu, Mei; Yu, Juehua] Kunming Med Univ, Ctr Expt Studies & Res, Affiliated Hosp 1, Kunming 650032, Peoples R China.
   [Zhu, Tailin] Xinhua Hosp Affiliated Shanghai Jiao Tong Univ, Shanghai Key Lab Childrens Environm Hlth, Minist Educ, Sch Med, Shanghai 200092, Peoples R China.
   [Shi, Kai] Guilin Univ Technol, Coll Sci, Guilin 541004, Peoples R China.
   [Xu, Yu] Kunming Med Univ, Dept Gastrointestinal Surg, Affiliated Hosp 1, Kunming 650032, Peoples R China.
   [Wang, Kunhua] Yunnan Univ, Sch Med, Kunming 650091, Peoples R China.
C3 Kunming Medical University; Kunming Medical University; Kunming
   University of Science & Technology; Kunming Medical University; Guilin
   University of Technology; Kunming Medical University; Yunnan University
RP Yu, JH; Wang, KH (通讯作者)，Kunming Med Univ, NHC Key Lab Drug Addict Med, Affiliated Hosp 1, Kunming 650032, Peoples R China.
EM juehuayu@gmail.com; wangkunhua1@163.com
RI Wu, Hongjin/AAF-6122-2019
OI Wu, Hongjin/0000-0002-2053-7441
FU National Natural Science Founda-tion of China, China [3171101074,
   81870458, 31860306]; Science and Technology Department of Yunnan
   Province, China [2018NS0086, 2019FE001, 202001AS070004, 202001AV070010];
   Major project of Yunnan Provincial Bureau of Education, China
   [2020J0161, 2021J0234]
FX Acknowledgements This study was supported by the National Natural
   Science Founda-tion of China, China, (No. 3171101074, No. 81870458, No.
   31860306) ; Science and Technology Department of Yunnan Province, China
   (Grant No. 2018NS0086, 2019FE001, 202001AS070004, 202001AV070010) ; The
   Major project of Yunnan Provincial Bureau of Education, China
   (2020J0161; 2021J0234) .
CR AlHussain F, 2020, PATIENT PREFER ADHER, V14, P737, DOI 10.2147/PPA.S244273
   Angoa-Perez M, 2021, PHARMACOL REV, V73, P571, DOI 10.1124/pharmrev.120.000144
   Arrieta MC, 2016, CELL HOST MICROBE, V19, P575, DOI 10.1016/j.chom.2016.04.014
   Barcena C, 2019, NAT MED, V25, P1234, DOI 10.1038/s41591-019-0504-5
   Brynildsen JK, 2018, P NATL ACAD SCI USA, V115, P4282, DOI 10.1073/pnas.1707047115
   Chen P, 2021, MOL BRAIN, V14, DOI 10.1186/s13041-021-00765-y
   Chen SB, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0120234
   Choi GE, 2021, NAT COMMUN, V12, DOI 10.1038/s41467-020-20679-y
   Coll AP, 2020, NATURE, V578, P444, DOI 10.1038/s41586-019-1911-y
   Cook RR, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-51142-8
   Correll CU, 2020, WORLD PSYCHIATRY, V19, P69, DOI 10.1002/wps.20714
   Darke S, 2008, DRUG ALCOHOL REV, V27, P253, DOI 10.1080/09595230801923702
   Das NK, 2020, CELL METAB, V31, P115, DOI 10.1016/j.cmet.2019.10.005
   Foretz M, 2014, CELL METAB, V20, P953, DOI 10.1016/j.cmet.2014.09.018
   Forouzan S, 2021, PSYCHOPHARMACOLOGY, V238, P281, DOI 10.1007/s00213-020-05681-y
   Fuks G, 2018, MICROBIOME, V6, DOI 10.1186/s40168-017-0396-x
   Gantois I, 2017, NAT MED, V23, P674, DOI 10.1038/nm.4335
   Glasner-Edwards S, 2010, AM J ADDICTION, V19, P385, DOI 10.1111/j.1521-0391.2010.00061.x
   Hall W, 1996, ADDICTION, V91, P81, DOI 10.1046/j.1360-0443.1996.9118110.x
   He BK, 2017, J EXP MED, V214, P107, DOI 10.1084/jem.20160961
   Hillmann B, 2018, MSYSTEMS, V3, DOI 10.1128/mSystems.00069-18
   Jameson KG, 2018, TRENDS NEUROSCI, V41, P413, DOI 10.1016/j.tins.2018.04.001
   Jin M, 2019, FRONT NEUROSCI-SWITZ, V13, DOI 10.3389/fnins.2019.01184
   Jung EM, 2017, NAT NEUROSCI, V20, P1694, DOI 10.1038/s41593-017-0013-0
   Kelly JR, 2017, BRAIN BEHAV IMMUN, V61, P50, DOI 10.1016/j.bbi.2016.11.018
   Kelly JR, 2016, J PSYCHIATR RES, V82, P109, DOI 10.1016/j.jpsychires.2016.07.019
   Keshavarzi S, 2019, NEUROTOXICOLOGY, V72, P74, DOI 10.1016/j.neuro.2019.02.004
   Kochalska K, 2020, NUTR RES, V82, P44, DOI 10.1016/j.nutres.2020.06.019
   Leshner AI, 1997, SCIENCE, V278, P45, DOI 10.1126/science.278.5335.45
   Mager LF, 2020, SCIENCE, V369, P1481, DOI 10.1126/science.abc3421
   Magnani P, 2010, PSYCHOPHARMACOLOGY, V210, P533, DOI 10.1007/s00213-010-1855-2
   Mardinoglu A, 2016, CELL METAB, V23, P10, DOI 10.1016/j.cmet.2015.12.012
   McClernon FJ, 2008, NEUROPSYCHOPHARMACOL, V33, P2148, DOI 10.1038/sj.npp.1301618
   McGregor C, 2005, ADDICTION, V100, P1320, DOI 10.1111/j.1360-0443.2005.01160.x
   McKetin R, 2008, DRUG ALCOHOL REV, V27, P277, DOI 10.1080/09595230801919486
   Muto J, 2014, SCI REP-UK, V4, DOI 10.1038/srep04199
   Sharon G, 2019, CELL, V177, P1600, DOI 10.1016/j.cell.2019.05.004
   Shi K, 2021, CLIN TRANSL MED, V11, DOI 10.1002/ctm2.314
   Strati F, 2017, MICROBIOME, V5, DOI 10.1186/s40168-017-0242-1
   Su LY, 2017, AUTOPHAGY, V13, P1496, DOI 10.1080/15548627.2017.1332549
   Sun MF, 2018, BRAIN BEHAV IMMUN, V70, P48, DOI 10.1016/j.bbi.2018.02.005
   Sun ZZ, 2020, APPL MICROBIOL BIOT, V104, P3507, DOI 10.1007/s00253-020-10461-x
   Szczesniak O, 2016, NUTR NEUROSCI, V19, P279, DOI 10.1179/1476830515Y.0000000007
   Wada N, 2020, MICROBIOME, V8, DOI 10.1186/s40168-020-00880-3
   Wang J, 2012, CELL STEM CELL, V11, P23, DOI 10.1016/j.stem.2012.03.016
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Wu XR, 2019, INT J ENV RES PUB HE, V16, DOI 10.3390/ijerph16081398
   Xu Y, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-03706-9
   Yuan S, 2018, NEUROREPORT, V29, P1223, DOI 10.1097/WNR.0000000000001101
   Zheng P, 2016, MOL PSYCHIATR, V21, P786, DOI 10.1038/mp.2016.44
   Zheng P, 2019, SCI ADV, V5, DOI 10.1126/sciadv.aau8317
   Zhu F, 2020, MOL PSYCHIATR, V25, P2905, DOI 10.1038/s41380-019-0475-4
   Zorick T, 2010, ADDICTION, V105, P1809, DOI 10.1111/j.1360-0443.2010.03066.x
NR 53
TC 6
Z9 6
U1 5
U2 19
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD MAY
PY 2022
VL 149
AR 112837
DI 10.1016/j.biopha.2022.112837
EA MAR 2022
PG 14
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 0Z7MH
UT WOS:000791257400002
PM 35339829
OA gold, Green Submitted
DA 2023-06-08
ER

PT J
AU Verdura, S
   Cuyas, E
   Martin-Castillo, B
   Menendez, JA
AF Verdura, Sara
   Cuyas, Elisabet
   Martin-Castillo, Begona
   Menendez, Javier A.
TI Metformin as an archetype immuno-metabolic adjuvant for cancer
   immunotherapy
SO ONCOIMMUNOLOGY
LA English
DT Article
DE Metformin; immunotherapy; T-cells; immune checkpoints
ID REGULATORY T-CELLS; GUT MICROBIOTA; BREAST-CANCER; PERSONALIZED
   IMMUNOTHERAPY; TUMOR MICROENVIRONMENT; INSULIN-RESISTANCE;
   PANCREATIC-CANCER; PD-L1 EXPRESSION; C. ELEGANS; MEMORY
AB The development of a single immuno-metabolic adjuvant capable of modulating, in the appropriate direction and intensity, the complex antagonistic and symbiotic interplays between tumor cells, immune cells, and the gut microbiota may appear pharmacologically implausible. Metformin might help solve this conundrum and beneficially impact the state of cancer-immune system interactions.
C1 [Verdura, Sara; Cuyas, Elisabet; Menendez, Javier A.] Catalan Inst Oncol, Metab & Canc Grp, Program Canc Therapeut Resistance ProCURE, Girona, Spain.
   [Verdura, Sara; Cuyas, Elisabet; Menendez, Javier A.] Girona Biomed Res Inst IDIBGI, Girona, Spain.
   [Martin-Castillo, Begona] Catalan Inst Oncol, Unit Clin Res, Girona, Spain.
C3 Institut Catala d'Oncologia; Universitat de Girona; Girona University
   Hospital Dr. Josep Trueta; Institut d'Investigacio Biomedica de Girona
   (IDIBGI); Institut Catala d'Oncologia
RP Menendez, JA (通讯作者)，Girona Biomed Res Inst IDIBGI, Catalan Inst Oncol ICO, Edifici M2,Parc Hosp Marti & Julia, E-17190 Salt, Girona, Spain.
EM jmenendez@iconcologia.net
RI Cuyas, Elisabet/G-8582-2018; verdura, Sara/AAC-3696-2022; MENENDEZ,
   JAVIER A/C-6148-2016
OI verdura, Sara/0000-0001-8980-0423; MENENDEZ, JAVIER
   A/0000-0001-8733-4561; Martin-Castillo, Begona/0000-0001-8344-8174
FU Spanish Ministry of Science and Innovation [SAF2016-80639-P]; Fundacio
   Oncolliga Girona (Lliga catalana d'ajuda al malalt de cancer, Girona)
FX Work in the Menendez laboratory is supported by the Spanish Ministry of
   Science and Innovation (Grant SAF2016-80639-P, Plan Nacional de l +D+I,
   founded by the European Regional Development Fund, Spain) and by an
   unrestricted research grant from the Fundacio Oncolliga Girona (Lliga
   catalana d'ajuda al malalt de cancer, Girona).
CR Afzal MZ, 2018, J IMMUNOTHER CANCER, V6, DOI 10.1186/s40425-018-0375-1
   Al-Wahab Z, 2015, ONCOTARGET, V6, P10908, DOI 10.18632/oncotarget.3434
   Alexander JL, 2017, NAT REV GASTRO HEPAT, V14, P356, DOI 10.1038/nrgastro.2017.20
   Allison KE, 2017, IMMUNOLOGY, V152, P175, DOI 10.1111/imm.12777
   Angelin A, 2017, CELL METAB, V25, P1282, DOI 10.1016/j.cmet.2016.12.018
   Araki K, 2010, IMMUNOL REV, V235, P234, DOI 10.1111/j.0105-2896.2010.00898.x
   Araki K, 2009, NATURE, V460, P108, DOI 10.1038/nature08155
   Barzilai N, 2016, CELL METAB, V23, P1060, DOI 10.1016/j.cmet.2016.05.011
   Blank C, 2004, CANCER RES, V64, P1140, DOI 10.1158/0008-5472.CAN-03-3259
   Blank CU, 2016, SCIENCE, V352, P658, DOI 10.1126/science.aaf2834
   Bohn T, 2018, NAT IMMUNOL, V19, P1319, DOI 10.1038/s41590-018-0226-8
   Bonanni B, 2012, J CLIN ONCOL, V30, P2593, DOI 10.1200/JCO.2011.39.3769
   Brennan CA, 2016, ANNU REV MICROBIOL, V70, P395, DOI 10.1146/annurev-micro-102215-095513
   Bridgeman SC, 2018, DIABETES OBES METAB, V20, P1553, DOI 10.1111/dom.13262
   Cabreiro F, 2013, CELL, V153, P228, DOI 10.1016/j.cell.2013.02.035
   Casey SC, 2016, SCIENCE, V352, P227, DOI 10.1126/science.aac9935
   Cha JH, 2018, MOL CELL, V71, P606, DOI 10.1016/j.molcel.2018.07.030
   Chae YK, 2018, ONCOLOGIST, V23, P410, DOI 10.1634/theoncologist.2017-0354
   Changizzadeh PN, 2017, J IMMUNOTHER CANCER, V5, DOI 10.1186/s40425-017-0303-9
   Chaput N, 2017, ANN ONCOL, V28, P1368, DOI 10.1093/annonc/mdx108
   Church SE, 2014, EUR J IMMUNOL, V44, P69, DOI 10.1002/eji.201343718
   Col NF, 2012, BREAST CANCER RES TR, V135, P639, DOI 10.1007/s10549-012-2170-x
   Colegio OR, 2014, NATURE, V513, P559, DOI 10.1038/nature13490
   Corominas-Faja B, 2012, AGING-US, V4, P480, DOI 10.18632/aging.100472
   Cortellini A, 2019, J IMMUNOTHER CANCER, V7, DOI 10.1186/s40425-019-0527-y
   Curry JM, 2018, FRONT ONCOL, V8, DOI 10.3389/fonc.2018.00436
   Cuyas E, 2018, ONCOGENE, V37, P963, DOI 10.1038/onc.2017.367
   Cuyas E, 2019, AGING-US, V11, P2874, DOI 10.18632/aging.101960
   Cuyas E, 2016, CELL CYCLE, V15, P3355, DOI 10.1080/15384101.2016.1249547
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   DeCensi A, 2014, BREAST CANCER RES TR, V148, P81, DOI 10.1007/s10549-014-3141-1
   DeCensi A, 2010, CANCER PREV RES, V3, P1451, DOI 10.1158/1940-6207.CAPR-10-0157
   Del Barco S, 2011, ONCOTARGET, V2, P896, DOI 10.18632/oncotarget.387
   Ding L, 2015, ONCOTARGET, V6, P36441, DOI 10.18632/oncotarget.5541
   Dong H, 2002, NAT REV IMMUNOL, V2, P545, DOI 10.1038/nm730
   Dreher LS, 2018, MOL CELL, V71, P481, DOI 10.1016/j.molcel.2018.08.001
   Eikawa S, 2015, P NATL ACAD SCI USA, V112, P1809, DOI 10.1073/pnas.1417636112
   Erskine CL, 2012, JOVE-J VIS EXP, DOI 10.3791/3683
   Foretz M, 2014, CELL METAB, V20, P953, DOI 10.1016/j.cmet.2014.09.018
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Furusawa Y, 2013, NATURE, V504, P446, DOI 10.1038/nature12721
   Galluzzi L, 2018, ONCOIMMUNOLOGY, V7, DOI 10.1080/2162402X.2018.1528815
   Gauci ML, 2017, CANCER IMMUNOL IMMUN, V66, P1399, DOI 10.1007/s00262-017-2033-8
   Godwin JL, 2017, J IMMUNOTHER CANCER, V5, DOI 10.1186/s40425-017-0245-2
   Goodwin PJ, 2011, BREAST CANCER RES TR, V126, P215, DOI 10.1007/s10549-010-1224-1
   Gopalakrishnan V, 2018, SCIENCE, V359, P97, DOI 10.1126/science.aan4236
   Gu WY, 2019, CLIN EXP PHARMACOL P, V46, P105, DOI 10.1111/1440-1681.13056
   Haikala HM, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-08541-2
   Han Y, 2019, AM J CANCER RES, V9, P800
   Henle AM, 2013, J IMMUNOL, V190, P479, DOI 10.4049/jimmunol.1201264
   Hirsch HA, 2013, P NATL ACAD SCI USA, V110, P972, DOI 10.1073/pnas.1221055110
   Ho PC, 2016, J IMMUNOTHER CANCER, V4, DOI 10.1186/s40425-016-0109-1
   Ho Y, 2018, FRONT PHARMACOL, V9, DOI 10.3389/fphar.2018.00807
   Iwai Y, 2002, P NATL ACAD SCI USA, V99, P12293, DOI 10.1073/pnas.192461099
   Kalender A, 2010, CELL METAB, V11, P390, DOI 10.1016/j.cmet.2010.03.014
   Karasaki T, 2017, J THORAC ONCOL, V12, P791, DOI 10.1016/j.jtho.2017.01.005
   Kataoka K, 2016, NATURE, V534, P402, DOI 10.1038/nature18294
   Kordes S, 2015, LANCET ONCOL, V16, P839, DOI 10.1016/S1470-2045(15)00027-3
   Kubo T, 2018, CLIN LUNG CANCER, V19, pE861, DOI 10.1016/j.cllc.2018.07.010
   Kunisada Y, 2017, EBIOMEDICINE, V25, P154, DOI 10.1016/j.ebiom.2017.10.009
   Kyriachenko Y, 2019, WORLD J DIABETES, V10, P154, DOI 10.4239/wjd.v10.i3.154
   Laidlaw BJ, 2015, NAT IMMUNOL, V16, P871, DOI 10.1038/ni.3224
   Lastwika KJ, 2016, CANCER RES, V76, P227, DOI 10.1158/0008-5472.CAN-14-3362
   Lee H, 2018, GUT MICROBES, V9, P155, DOI 10.1080/19490976.2017.1405209
   Lettieri-Barbato D, 2018, FRONT ONCOL, V8, DOI 10.3389/fonc.2018.00148
   Li XY, 2019, NAT REV CLIN ONCOL, V16, P425, DOI 10.1038/s41571-019-0203-7
   Maamari J, 2019, AM J EMERG MED, V37, DOI 10.1016/j.ajem.2018.10.040
   Mandai M, 2016, CLIN CANCER RES, V22, P2329, DOI 10.1158/1078-0432.CCR-16-0224
   Martin-Castillo Begona, 2018, Oncotarget, V9, P35687, DOI 10.18632/oncotarget.26286
   Marzec M, 2008, P NATL ACAD SCI USA, V105, P20852, DOI 10.1073/pnas.0810958105
   Matson V, 2018, SCIENCE, V359, P104, DOI 10.1126/science.aao3290
   Mezzadra R, 2017, NATURE, V549, P106, DOI 10.1038/nature23669
   Munipally PK, 2011, ARCH PHYSIOL BIOCHEM, V117, P254, DOI 10.3109/13813455.2011.623705
   Muzik O, 2017, BIOCHEM BIOPH RES CO, V488, P29, DOI 10.1016/j.bbrc.2017.04.155
   Oliveras-Ferraros C, 2012, CELL CYCLE, V11, P865, DOI 10.4161/cc.11.5.19252
   Patsoukis N, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms7692
   Pearce EL, 2009, NATURE, V460, P103, DOI 10.1038/nature08097
   Pereira Felipe V, 2018, Oncotarget, V9, P25808, DOI 10.18632/oncotarget.25380
   Pietras R, 2018, J THORAC ONCOL, V13, pS538, DOI 10.1016/j.jtho.2018.08.748
   Pietrocola F, 2017, ONCOTARGET, V8, P9017, DOI 10.18632/oncotarget.14794
   Pollak M, 2017, DIABETOLOGIA, V60, P1662, DOI 10.1007/s00125-017-4352-x
   Pollak M, 2013, J CLIN INVEST, V123, P3693, DOI 10.1172/JCI67232
   Pollak MN, 2012, CANCER DISCOV, V2, P778, DOI 10.1158/2159-8290.CD-12-0263
   Prlic M, 2009, NATURE, V460, P41, DOI 10.1038/460041a
   Qorraj M, 2017, ONCOTARGET, V8, P73364, DOI 10.18632/oncotarget.20639
   Reni M, 2016, CLIN CANCER RES, V22, P1076, DOI 10.1158/1078-0432.CCR-15-1722
   Renner K, 2017, FRONT IMMUNOL, V8, DOI 10.3389/fimmu.2017.00248
   Rogado J, 2019, EUR J CANCER, V109, P21, DOI 10.1016/j.ejca.2018.10.014
   Rom-Jurek EM, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19020563
   Routy B, 2018, NAT REV CLIN ONCOL, V15, P382, DOI 10.1038/s41571-018-0006-2
   Routy B, 2018, SCIENCE, V359, P91, DOI 10.1126/science.aan3706
   Roy S, 2017, NAT REV CANCER, V17, P271, DOI 10.1038/nrc.2017.13
   Scharping NE, 2017, CANCER IMMUNOL RES, V5, P9, DOI 10.1158/2326-6066.CIR-16-0103
   Schuler KM, 2015, CANCER MED-US, V4, P161, DOI 10.1002/cam4.353
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Singer K, 2018, DIS MODEL MECH, V11, DOI 10.1242/dmm.034272
   Smith PM, 2013, SCIENCE, V341, P569, DOI 10.1126/science.1241165
   Spencer CN, 2019, TRENDS CANCER, V5, P79, DOI 10.1016/j.trecan.2018.12.003
   Sugiura A, 2018, J IMMUNOL, V200, P400, DOI 10.4049/jimmunol.1701041
   Tarantino P, 2019, EXPERT OPIN BIOL TH, V19, P383, DOI 10.1080/14712598.2019.1598372
   Uehara T, 2019, INT IMMUNOL, V31, P187, DOI 10.1093/intimm/dxy079
   van Dijk N, 2019, EUR UROL, V75, P435, DOI 10.1016/j.eururo.2018.09.022
   Vetizou M, 2015, SCIENCE, V350, P1079, DOI 10.1126/science.aad1329
   Walker LSK, 2015, TRENDS IMMUNOL, V36, P63, DOI 10.1016/j.it.2014.12.001
   Walker LSK, 2013, J AUTOIMMUN, V45, P49, DOI 10.1016/j.jaut.2013.06.006
   Wang YT, 2018, FRONT PHARMACOL, V9, DOI 10.3389/fphar.2018.00536
   Wang ZM, 2019, NAT MED, V25, P141, DOI 10.1038/s41591-018-0221-5
   Wei F, 2013, P NATL ACAD SCI USA, V110, pE2480, DOI 10.1073/pnas.1305394110
   Wherry EJ, 2011, NAT IMMUNOL, V12, P492, DOI 10.1038/ni.2035
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Wu LF, 2016, CELL, V167, P1705, DOI 10.1016/j.cell.2016.11.055
   Xu CX, 2014, CANCER CELL, V25, P590, DOI 10.1016/j.ccr.2014.03.033
   Xu S, 2018, MOL CANCER THER, V17, P1291, DOI 10.1158/1535-7163.MCT-17-0927
   Yi M, 2018, J HEMATOL ONCOL, V11, DOI 10.1186/s13045-018-0592-6
   Zahoor H, 2019, EUR UROL, V75, P445, DOI 10.1016/j.eururo.2018.12.005
   Zhou HQ, 2019, CANCER CHEMOTH PHARM, V83, P599, DOI 10.1007/s00280-018-03763-5
   Zitvogel L, 2015, SCI TRANSL MED, V7, DOI 10.1126/scitranslmed.3010473
NR 117
TC 48
Z9 49
U1 2
U2 14
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 2162-402X
J9 ONCOIMMUNOLOGY
JI OncoImmunology
PD OCT 3
PY 2019
VL 8
IS 10
DI 10.1080/2162402X.2019.1633235
EA JUN 2019
PG 10
WC Oncology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Immunology
GA IS5WF
UT WOS:000475285500001
PM 31646077
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Kang, ZQ
   Hu, JL
   Chen, MY
   Mao, Y
   Xie, LF
   Yang, NA
   Liu, T
   Zhang, W
   Huang, WH
AF Kang, Zhi-Qiang
   Hu, Jing-Lei
   Chen, Man-Yun
   Mao, Yu
   Xie, Li-Fang
   Yang, Nian
   Liu, Tao
   Zhang, Wei
   Huang, Wei-Hua
TI Effects of Capsaicin on the Hypoglycemic Regulation of Metformin and Gut
   Microbiota Profiles in Type 2 Diabetic Rats
SO AMERICAN JOURNAL OF CHINESE MEDICINE
LA English
DT Article
DE Capsaicin; Gut Microbiota; Metformin; Hypoglycemic Effect; Akkermansia
ID INTESTINAL MICROBIOTA; INFLAMMATION; METABOLISM; RESPONSES; ALTERS;
   IMPACT; ONSET
AB Dietary capsaicin (CAP), the main irritant component in pepper, can reduce the incidence of diabetes, while metformin (MET) is a first-line oral hypoglycemic drug. The purpose of this study was to investigate whether CAP on the hypoglycemic effect of MET is pertinent to gut microbiota. The glucose and insulin tolerance of diabetic rats were monitored. The glycolipid metabolism was analyzed by detecting blood biochemical parameters. Liver pathological changes were observed by Hematoxylin eosin (HE) staining. The inflammatory cytokines and intestinal tight junction proteins were detected by RT-qPCR and Western blot. 16S rRNA sequencing was employed to analyze gut microbiota profiles. The results showed that CAP and MET co-treatment could significantly reduce fasting blood glucose, improve glucose tolerance, lessen liver injury and inflammatory infiltration, down-regulate inflammatory cytokines and up-regulate intestinal tight junction proteins in diabetic rats by comparing it with MET monotherapy. Moreover, CAP and MET co-treatment altered gut microbiota profiles by regulating microbials' abundances such as Akkermansia. In conclusion, CAP showed the significant hypoglycemic effect of MET and remodulated gut microbiota profiles in diabetic rats.
C1 [Kang, Zhi-Qiang; Mao, Yu; Xie, Li-Fang] Zhengzhou Univ, Dept Endocrinol, Zhengzhou Cent Hosp, Zhengzhou 450007, Henan, Peoples R China.
   [Hu, Jing-Lei; Chen, Man-Yun; Yang, Nian; Zhang, Wei; Huang, Wei-Hua] Cent South Univ, Xiangya Hosp, Dept Clin Pharmacol, Changsha 410008, Peoples R China.
   [Hu, Jing-Lei; Chen, Man-Yun; Yang, Nian; Zhang, Wei; Huang, Wei-Hua] Cent South Univ, Inst Clin Pharmacol, Hunan Key Lab Pharmacogenet, Changsha 410078, Peoples R China.
   [Hu, Jing-Lei; Chen, Man-Yun; Yang, Nian; Zhang, Wei; Huang, Wei-Hua] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Xiangya Rd 110, Changsha 410008, Peoples R China.
   [Liu, Tao] Shenzhen Ctr Chron Dis Control, Shenzhen 518020, Peoples R China.
   [Huang, Wei-Hua] Hunan Prov Maternal & Child Hlth Care Hosp, NHC Key Lab Birth Defect Res & Prevent, Changsha 410008, Hunan, Peoples R China.
C3 Zhengzhou University; Central South University; Central South
   University; Central South University
RP Zhang, W; Huang, WH (通讯作者)，Cent South Univ, Xiangya Hosp, Dept Clin Pharmacol, Changsha 410008, Peoples R China.; Zhang, W; Huang, WH (通讯作者)，Cent South Univ, Inst Clin Pharmacol, Hunan Key Lab Pharmacogenet, Changsha 410078, Peoples R China.; Zhang, W; Huang, WH (通讯作者)，Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Xiangya Rd 110, Changsha 410008, Peoples R China.; Liu, T (通讯作者)，Shenzhen Ctr Chron Dis Control, Shenzhen 518020, Peoples R China.; Huang, WH (通讯作者)，Hunan Prov Maternal & Child Hlth Care Hosp, NHC Key Lab Birth Defect Res & Prevent, Changsha 410008, Hunan, Peoples R China.
EM liutao319@163.com; csuzhangwei@csu.edu.cn; endeavor34852@csu.edu.cn
OI Huang, Wei-Hua/0000-0003-4167-8304
FU National Natural Scientific Foundation of China [82074000, 81874329,
   82073945]; National Key Research and DevelopmentProgram of China
   [2021YFA1301200]; Hunan Provincial Natural Science Foundation of China
   [2020JJ4878]; Science and Technology Benefiting People Plan of Zhengzhou
   [2020KJHM0028]; Medical Science and Technology Research Plan of Henan
   Province [2018020762]; Scientific Research Project of Department of
   Education of Hunan Province [20K136]; Sanming Project of Medicine in
   Shenzhen [SZSM201811057]; NHC Key Laboratory of Birth Defect for
   Research and Prevention (Hunan Provincial Maternal and Child Health Care
   Hospital) [KF2020002]
FX This work was supported by the National Natural Scienti~c Foundation of
   China (82074000, 81874329 and 82073945) the National Key Research and
   DevelopmentProgram of China (No. 2021YFA1301200), the Hunan Provincial
   Natural Science Foundation of China (2020JJ4878), Science and Technology
   Bene~ting People Plan of Zhengzhou (2020KJHM0028), Medical Science and
   Technology Research Plan of Henan Province (2018020762), the Scienti~c
   Research Project of Department of Education of Hunan Province (20K136),
   Sanming Project of Medicine in Shenzhen (SZSM201811057) and NHC Key
   Laboratory of Birth Defect for Research and Prevention (Hunan Provincial
   Maternal and Child Health Care Hospital, No. KF2020002).
CR Agus A, 2018, CELL HOST MICROBE, V23, P716, DOI 10.1016/j.chom.2018.05.003
   Bauer PV, 2018, CELL METAB, V27, P101, DOI 10.1016/j.cmet.2017.09.019
   Candela M, 2016, BRIT J NUTR, V116, P80, DOI 10.1017/S0007114516001045
   Chen TL, 2016, SCI REP-UK, V6, DOI 10.1038/srep20594
   Cho NH, 2018, DIABETES RES CLIN PR, V138, P271, DOI 10.1016/j.diabres.2018.02.023
   Faber F, 2014, IMMUNOL LETT, V162, P48, DOI 10.1016/j.imlet.2014.04.014
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Gregor MF, 2011, ANNU REV IMMUNOL, V29, P415, DOI 10.1146/annurev-immunol-031210-101322
   Hui SC, 2020, FASEB J, V34, P8558, DOI 10.1096/fj.201902618RR
   Kang C, 2017, MBIO, V8, DOI [10.1128/mBio.00470-17, 10.1128/mBio.00900-17, 10.1128/mbio.00470-17]
   Kim Y, 2020, GUT MICROBES, V11, DOI 10.1080/19490976.2020.1730149
   Koh A, 2020, CELL METAB, V32, P643, DOI 10.1016/j.cmet.2020.07.012
   Koh A, 2018, CELL, V175, P947, DOI 10.1016/j.cell.2018.09.055
   Krych L, 2015, GUT MICROBES, V6, P101, DOI 10.1080/19490976.2015.1011876
   Li K, 2019, FOOD FUNCT, V10, P1915, DOI 10.1039/c8fo02265h
   Ma Y, 2016, INFLAMMATION, V39, P1453, DOI 10.1007/s10753-016-0377-4
   Ouyang J, 2020, AIDS RES THER, V17, DOI 10.1186/s12981-020-00267-2
   Panchal SK, 2018, NUTRIENTS, V10, DOI 10.3390/nu10050630
   Pandurangan M, 2016, 3 BIOTECH, V6, DOI 10.1007/s13205-016-0411-0
   Patowary P, 2017, BIOMED PHARMACOTHER, V96, P1501, DOI 10.1016/j.biopha.2017.11.124
   Patterson E, 2015, MICROBIOL-SGM, V161, P182, DOI 10.1099/mic.0.082610-0
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Si X, 2018, MOL NUTR FOOD RES, V62, DOI 10.1002/mnfr.201700670
   Sircana A, 2018, CURR DIABETES REP, V18, DOI 10.1007/s11892-018-1057-6
   Turpin W, 2016, NAT GENET, V48, P1413, DOI 10.1038/ng.3693
   White PJ, 2019, SCIENCE, V363, P582, DOI 10.1126/science.aav0558
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Yu M, 2017, SCI REP-UK, V7, DOI 10.1038/srep46551
   Zhao XQ, 2020, BIOMED PHARMACOTHER, V121, DOI 10.1016/j.biopha.2019.109559
   Zhao ZY, 2020, J DIABETES, V12, P270, DOI 10.1111/1753-0407.12967
NR 30
TC 1
Z9 1
U1 4
U2 16
PU WORLD SCIENTIFIC PUBL CO PTE LTD
PI SINGAPORE
PA 5 TOH TUCK LINK, SINGAPORE 596224, SINGAPORE
SN 0192-415X
EI 1793-6853
J9 AM J CHINESE MED
JI Am. J. Chin. Med.
PY 2022
VL 50
IS 03
BP 839
EP 861
DI 10.1142/S0192415X22500355
PG 23
WC Integrative & Complementary Medicine; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine; General & Internal Medicine
GA 0U7US
UT WOS:000787854100011
PM 35300567
DA 2023-06-08
ER

PT J
AU Yerevanian, A
   Soukas, AA
AF Yerevanian, Armen
   Soukas, Alexander A.
TI Metformin: Mechanisms in Human Obesity and Weight Loss
SO CURRENT OBESITY REPORTS
LA English
DT Article
DE Metformin; Obesity; Weight loss; Appetite regulation; Type 2 diabetes;
   Aging
ID TYPE-2 DIABETES-MELLITUS; CATION TRANSPORTER 1; GLUCOSE-PRODUCTION;
   FOOD-INTAKE; AMERICAN ASSOCIATION; INSULIN THERAPY; AMPK; METABOLISM;
   ACTIVATION; KINASE
AB Purpose of ReviewMetformin has multiple benefits for health beyond its anti-hyperglycemic properties. The purpose of this manuscript is to review the mechanisms that underlie metformin's effects on obesity.Recent FindingsMetformin is a first-line therapy for type 2 diabetes. Large cohort studies have shown weight loss benefits associated with metformin therapy. Metabolic consequences were traditionally thought to underlie this effect, including reduction in hepatic gluconeogenesis and reduction in insulin production. Emerging evidence suggests that metformin-associated weight loss is due to modulation of hypothalamic appetite regulatory centers, alteration in the gut microbiome, and reversal of consequences of aging. Metformin is also being explored in the management of obesity's sequelae such as hepatic steatosis, obstructive sleep apnea, and osteoarthritis.SummaryMultiple mechanisms underlie the weight loss-inducing and health-promoting effects of metformin. Further exploration of these pathways may be important in identifying new pharmacologic targets for obesity and other aging-associated metabolic diseases.
C1 [Yerevanian, Armen; Soukas, Alexander A.] Massachusetts Gen Hosp, Endocrine Div, Diabet Unit, Dept Med, 185 Cambridge St,CPZN6224, Boston, MA 02114 USA.
   [Yerevanian, Armen; Soukas, Alexander A.] Massachusetts Gen Hosp, Ctr Genom Med, 185 Cambridge St,CPZN6224, Boston, MA 02114 USA.
   [Yerevanian, Armen; Soukas, Alexander A.] Harvard Med Sch, Dept Med, Boston, MA 02114 USA.
   [Yerevanian, Armen; Soukas, Alexander A.] Broad Inst Harvard & MIT, Cambridge, MA 02142 USA.
C3 Harvard University; Massachusetts General Hospital; Harvard University;
   Massachusetts General Hospital; Harvard University; Harvard Medical
   School; Harvard University; Massachusetts Institute of Technology (MIT);
   Broad Institute
RP Soukas, AA (通讯作者)，Massachusetts Gen Hosp, Endocrine Div, Diabet Unit, Dept Med, 185 Cambridge St,CPZN6224, Boston, MA 02114 USA.; Soukas, AA (通讯作者)，Massachusetts Gen Hosp, Ctr Genom Med, 185 Cambridge St,CPZN6224, Boston, MA 02114 USA.; Soukas, AA (通讯作者)，Harvard Med Sch, Dept Med, Boston, MA 02114 USA.; Soukas, AA (通讯作者)，Broad Inst Harvard & MIT, Cambridge, MA 02142 USA.
EM asoukas@mgh.harvard.edu
FU NIH [R01AG058256, R01DK101522, R01DK072041]; Weissman Family MGH
   Research Scholar Award; Glenn Award for Research in the Biological
   Mechanisms of Aging; NIH-NIDDK [T32DK007028]
FX This work was supported by NIH R01AG058256, R01DK101522, and
   R01DK072041, the Weissman Family MGH Research Scholar Award, and a Glenn
   Award for Research in the Biological Mechanisms of Aging (to AS). AY is
   supported by the NIH-NIDDK funded MGH Endocrinology training grant
   T32DK007028.
CR American Diabetes Association, 2019, Clin Diabetes, V37, P11, DOI 10.2337/cd18-0105
   Apovian CM, 2015, J CLIN ENDOCR METAB, V100, P342, DOI 10.1210/jc.2014-3415
   Aubert G, 2011, METABOLISM, V60, P327, DOI 10.1016/j.metabol.2010.02.007
   BAILEY CJ, 1992, BRIT J PHARMACOL, V105, P1009, DOI 10.1111/j.1476-5381.1992.tb09093.x
   Bailey CJ, 2017, DIABETOLOGIA, V60, P1566, DOI 10.1007/s00125-017-4318-z
   Barzilai N, 2016, CELL METAB, V23, P1060, DOI 10.1016/j.cmet.2016.05.011
   Bauer PV, 2018, CELL METAB, V27, P101, DOI 10.1016/j.cmet.2017.09.019
   Bliddal H, 2014, OBES REV, V15, P578, DOI 10.1111/obr.12173
   Blokhin IO, 2013, CURR OPIN HEMATOL, V20, P437, DOI 10.1097/MOH.0b013e3283634443
   Bonds DE, 2006, J CLIN ENDOCR METAB, V91, P3404, DOI 10.1210/jc.2006-0614
   Bouchard DR, 2009, OBESITY, V17, P2082, DOI 10.1038/oby.2009.109
   Bray GA, 2012, DIABETES CARE, V35, P731, DOI 10.2337/dc11-1299
   Buse JB, 2016, DIABETES CARE, V39, P198, DOI 10.2337/dc15-0488
   Cabreiro F, 2013, CELL, V153, P228, DOI 10.1016/j.cell.2013.02.035
   Cani PD, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.01765
   Castillo-Quan JI, 2016, CELL, V167, P1670, DOI 10.1016/j.cell.2016.11.058
   Chalasani NP, 2017, HEPATOLOGY, V66, p303A
   Chari M, 2008, DIABETES, V57, P836, DOI 10.2337/db07-1464
   Chau-Van C, 2007, ENDOCRINOLOGY, V148, P507, DOI 10.1210/en.2006-1237
   Chen DH, 2016, CELL DEATH DIS, V7, DOI 10.1038/cddis.2016.334
   Claret M, 2007, J CLIN INVEST, V117, P2325, DOI 10.1172/JCI31516
   Cubeddu LX, 2000, N-S ARCH PHARMACOL, V361, P85, DOI 10.1007/s002109900152
   D'Angelo MA, 2009, CELL, V136, P284, DOI 10.1016/j.cell.2008.11.037
   de Liefde II, 2005, OSTEOPOROSIS INT, V16, P1713, DOI 10.1007/s00198-005-1909-1
   de Silva VA, 2016, BMC PSYCHIATRY, V16, DOI 10.1186/s12888-016-1049-5
   de Wit S, 2009, J NEUROSCI, V29, P11330, DOI 10.1523/JNEUROSCI.1639-09.2009
   DEFRONZO RA, 1995, NEW ENGL J MED, V333, P541, DOI 10.1056/NEJM199508313330902
   DeFronzo RA, 2016, DIABETOLOGIA, V59, P1645, DOI 10.1007/s00125-016-3992-6
   Duan Y, 2013, NEURAL REGEN RES, V8, P2379, DOI 10.3969/j.issn.1673-5374.2013.25.009
   Duca FA, 2015, NAT MED, V21, P506, DOI 10.1038/nm.3787
   Dujic T, 2016, DIABETIC MED, V33, P511, DOI 10.1111/dme.13040
   Dujic T, 2015, DIABETES, V64, P1786, DOI 10.2337/db14-1388
   El-Mir MY, 2000, J BIOL CHEM, V275, P223, DOI 10.1074/jbc.275.1.223
   Fontbonne A, 1996, DIABETES CARE, V19, P920, DOI 10.2337/diacare.19.9.920
   Foretz M, 2010, J CLIN INVEST, V120, P2355, DOI 10.1172/JCI40671
   Garvey WT, 2016, ENDOCR PRACT, V22, P842, DOI 10.4158/EP161356.ESGL
   GBD 2015 Obesity Collaborators, 2017, N Engl J Med, V377, P13, DOI 10.1056/NEJMoa1614362
   Glueck CJ, 2001, METABOLISM, V50, P856, DOI 10.1053/meta.2001.24192
   Golay A, 2008, INT J OBESITY, V32, P61, DOI 10.1038/sj.ijo.0803695
   Gontier E, 2008, EUR J NUCL MED MOL I, V35, P95, DOI 10.1007/s00259-007-0563-6
   He L, 2015, CELL METAB, V21, P159, DOI 10.1016/j.cmet.2015.01.003
   Holman RR, 2008, NEW ENGL J MED, V359, P1577, DOI 10.1056/NEJMoa0806470
   Huang YC, 2014, SCI WORLD J, DOI 10.1155/2014/694326
   Huerta CI, 2014, OBESITY, V22, P1439, DOI 10.1002/oby.20659
   Hundal RS, 2000, DIABETES, V49, P2063, DOI 10.2337/diabetes.49.12.2063
   Inzucchi SE, 1998, NEW ENGL J MED, V338, P867, DOI 10.1056/NEJM199803263381303
   Islam H, 2017, J APPL PHYSIOL, V123, P614, DOI 10.1152/japplphysiol.00218.2017
   Jeyabalan J, 2013, OSTEOPOROSIS INT, V24, P2659, DOI 10.1007/s00198-013-2371-0
   Johnson SC, 2013, NATURE, V493, P338, DOI 10.1038/nature11861
   Kahn SE, 2006, NEW ENGL J MED, V355, P2427, DOI 10.1056/NEJMoa066224
   Kalantar-Zadeh K, 2004, SEMIN DIALYSIS, V17, P455, DOI 10.1111/j.0894-0959.2004.17606.x
   Kalender A, 2010, CELL METAB, V11, P390, DOI 10.1016/j.cmet.2010.03.014
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kim HJ, 2018, MEDICINE, V97, DOI 10.1097/MD.0000000000010036
   Kim YW, 2006, DIABETES, V55, P716, DOI 10.2337/diabetes.55.03.06.db05-0917
   Kooy A, 2009, ARCH INTERN MED, V169, P616, DOI 10.1001/archinternmed.2009.20
   Kuhre RE, 2018, MOL METAB, V11, P84, DOI 10.1016/j.molmet.2018.03.007
   Labuzek K, 2010, PHARMACOL REP, V62, P956
   Lam CKL, 2008, AM J PHYSIOL-ENDOC M, V295, pE491, DOI 10.1152/ajpendo.90481.2008
   Lavrentaki A, 2018, EUR J ENDOCRINOL
   Lee A, 1998, OBES RES, V6, P47, DOI 10.1002/j.1550-8528.1998.tb00314.x
   Lee N, 2014, J BIOL CHEM, V289, P27055, DOI 10.1074/jbc.M114.570564
   Levri KM, 2005, ANN FAM MED, V3, P457, DOI 10.1370/afm.343
   Li Y, 2013, BIOMED REP, V1, P57, DOI 10.3892/br.2012.18
   Lien F, 2014, J CLIN INVEST, V124, P1037, DOI 10.1172/JCI68815
   Lin D, 2015, J SLEEP MED DISORD, V2
   Long DE, 2017, TRIALS, V18, DOI 10.1186/s13063-017-1932-5
   Lu CH, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0191242
   Lu DY, 2014, BMC CARDIOVASC DISOR, V14, DOI 10.1186/1471-2261-14-187
   Lv WS, 2012, BRAIN RES, V1444, P11, DOI 10.1016/j.brainres.2012.01.028
   Madiraju AK, 2018, NAT MED, V24, P1384, DOI 10.1038/s41591-018-0125-4
   Madiraju AK, 2014, NATURE, V510, P542, DOI 10.1038/nature13270
   Makimattila S, 1999, DIABETOLOGIA, V42, P406, DOI 10.1007/s001250051172
   Maruvada P, 2017, CELL HOST MICROBE, V22, P589, DOI 10.1016/j.chom.2017.10.005
   McCreight LJ, 2016, DIABETOLOGIA, V59, P426, DOI 10.1007/s00125-015-3844-9
   Miller RA, 2013, NATURE, V494, P256, DOI 10.1038/nature11808
   Miller RA, 2010, J CLIN INVEST, V120, P2267, DOI 10.1172/JCI43661
   Morrison DJ, 2016, GUT MICROBES, V7, P189, DOI 10.1080/19490976.2015.1134082
   Mulherin AJ, 2011, ENDOCRINOLOGY, V152, P4610, DOI 10.1210/en.2011-1485
   NAPOLITANO A, 2014, NAPOLITANO A, V9
   Nordklint AK, 2018, OSTEOPOROSIS INT, V29, P2517, DOI 10.1007/s00198-018-4637-z
   Onken B, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0008758
   Owen MR, 2000, BIOCHEM J, V348, P607, DOI 10.1042/0264-6021:3480607
   Paolisso G, 1998, EUR J CLIN INVEST, V28, P441, DOI 10.1046/j.1365-2362.1998.00304.x
   Saenz A, 2005, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD002966.pub3
   Schiffman Susan S, 2018, World J Otorhinolaryngol Head Neck Surg, V4, P84, DOI 10.1016/j.wjorl.2018.02.005
   Schwartz AV, 2017, DIABETOLOGIA, V60, P1170, DOI 10.1007/s00125-017-4283-6
   Shaw RJ, 2005, SCIENCE, V310, P1642, DOI 10.1126/science.1120781
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Stark R, 2013, MOL CELL ENDOCRINOL, V366, P215, DOI 10.1016/j.mce.2012.06.012
   Stevanovic D, 2012, NEUROENDOCRINOLOGY, V96, P24, DOI 10.1159/000333963
   STUMVOLL M, 1995, NEW ENGL J MED, V333, P550, DOI 10.1056/NEJM199508313330903
   Tokubuchi I, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0171293
   Vaisse C, 1996, NAT GENET, V14, P95, DOI 10.1038/ng0996-95
   Werner EA, 1922, J CHEM SOC, V121, P1790, DOI 10.1039/ct9222101790
   WILCOCK C, 1994, XENOBIOTICA, V24, P49, DOI 10.3109/00498259409043220
   Witters LA, 2001, J CLIN INVEST, V108, P1105, DOI 10.1172/JCI14178
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Wu LF, 2016, CELL, V167, P1705, DOI 10.1016/j.cell.2016.11.055
   Xin G, 2016, SCI REP-UK, V6, DOI 10.1038/srep36222
   Yki-Jarvinen H, 1999, DRUGS, V58, P53, DOI 10.2165/00003495-199958001-00012
   Zhang XQ, 2015, SCI REP-UK, V5, DOI 10.1038/srep10737
   Zhou GC, 2001, J CLIN INVEST, V108, P1167, DOI 10.1172/JCI200113505
NR 103
TC 119
Z9 124
U1 4
U2 45
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 2162-4968
J9 CURR OBES REP
JI Curr. Obes. Rep.
PD JUN
PY 2019
VL 8
IS 2
BP 156
EP 164
DI 10.1007/s13679-019-00335-3
PG 9
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA HY5ED
UT WOS:000468149200010
PM 30874963
OA Green Accepted
HC Y
HP N
DA 2023-06-08
ER

PT J
AU Zhang, C
   Ma, SS
   Wu, JH
   Luo, LL
   Qiao, SY
   Li, RX
   Xu, WJ
   Wang, N
   Zhao, BS
   Wang, X
   Zhang, Y
   Wang, XY
AF Zhang, Chi
   Ma, Shuangshuang
   Wu, Jiahui
   Luo, Linglong
   Qiao, Sanyang
   Li, Ruxin
   Xu, Wenjuan
   Wang, Nan
   Zhao, Baosheng
   Wang, Xiao
   Zhang, Yuan
   Wang, Xueyong
TI A specific gut microbiota and metabolomic profiles shifts related to
   antidiabetic action: The similar and complementary antidiabetic
   properties of type 3 resistant starch from Canna edulis and metformin
SO PHARMACOLOGICAL RESEARCH
LA English
DT Article
DE Microbiome; Metabolomics; T2DM; Metformin; Ce-RS3
ID DIABETES-MELLITUS; INSULIN-RESISTANCE; LINOLEIC-ACID; FATTY-ACIDS;
   OBESITY; WEIGHT; HYPERGLYCEMIA; INFLAMMATION; INDIVIDUALS; ASSOCIATION
AB The relationship between gut microbiota and type 2 diabetes mellitus (T2DM) has drawn increasing attention, and the benefits of various treatment strategies, including nutrition, medication and physical exercise, maybe microbially-mediated. Metformin is a widely used hypoglycemic agent, while resistant starch (RS) is a novel dietary fiber that emerges as a nutritional strategy for metabolic disease. However, it remains unclear as to the potential degree and interactions among gut microbial communities, metabolic landscape, and the anti-diabetic effects of metformin and RS, especially for a novel type 3 resistant starch from Canna edulis (Ce-RS3). In the present study, T2DM rats were administered metformin or Ce-RS3, and the changes in gut microbiota and serum metabolic profiles were characterized using 16S-rRNA gene sequencing and metabolomics, respectively. After 11 weeks of treatment, Ce-RS3 exhibited similar anti-diabetic effects to those of metformin, including dramatically reducing blood glucose, ameliorating the response to insulin resistance and glucose tolerance test, and relieving the pathological damage in T2DM rats. Interestingly, the microbial and systemic metabolic dysbiosis in T2DM rats was effectively modulated by both Ce-RS3 and, to a lesser extent, metformin. The two treatments increased the gut bacterial diversity, and supported the restoration of SCFA-producing bacteria, thereby significantly increasing SCFAs levels. Both treatments simultaneously corrected 16 abnormal metabolites in the metabolism of lipids and amino acids, many of which are microbiome-related. PICRUSt analysis and correlation of SCFAs levels with metabolomics data revealed a strong association between gut microbial and host metabolic changes.
   Strikingly, Ce-RS3 exhibited better efficacy in increasing gut microbiota diversity with a peculiar enrichment of Prevotella genera. The gut microbial properties of Ce-RS3 were tightly associated with the T2DM-related indexes, showing the potential to alleviate diabetic phenotype dysbioses, and possibly explaining the greater efficiency in improving metabolic control.
C1 [Zhang, Chi; Ma, Shuangshuang; Wu, Jiahui; Luo, Linglong; Qiao, Sanyang; Li, Ruxin; Xu, Wenjuan; Wang, Nan; Wang, Xueyong] Beijing Univ Chinese Med, Sch Chinese Meteria Med, Northeast Corner Intersect Sunshine South St & Ba, Beijing 102488, Peoples R China.
   [Zhao, Baosheng] Beijing Univ Chinese Med, Beijing Res Inst Chinese Med, Beijing 100029, Peoples R China.
   [Wang, Xiao] Qilu Univ Technol, Coll Pharm, Shandong Acad Sci, Jinan 250014, Shandong, Peoples R China.
   [Zhang, Yuan] Beijing Union Univ, Coll Biochem Engn, 18 Fatou Xifi Dist, Beijing 100023, Peoples R China.
C3 Beijing University of Chinese Medicine; Beijing University of Chinese
   Medicine; Qilu University of Technology; Beijing Union University
RP Wang, XY (通讯作者)，Beijing Univ Chinese Med, Sch Chinese Meteria Med, Northeast Corner Intersect Sunshine South St & Ba, Beijing 102488, Peoples R China.
EM wxyph.d@163.com
RI wang, xiao/HZI-9156-2023
FU National Science & Technology Fundamental Resources Investigation
   Program of China [2018FY100700]; National Natural Science Foundation of
   China [81773841]; Science & Technology Support Plan of Guizhou Province
   [2017MA6DRXM2320354]
FX This work was supported by grants from the National Science & Technology
   Fundamental Resources Investigation Program of China (2018FY100700), the
   National Natural Science Foundation of China (81773841) and the Science
   & Technology Support Plan of Guizhou Province (2017MA6DRXM2320354).
CR Abu Bakar MH, 2017, MOL BIOSYST, V13, P1838, DOI 10.1039/c7mb00333a
   Bagger JI, 2011, J CLIN ENDOCR METAB, V96, P737, DOI 10.1210/jc.2010-2435
   Barengolts E, 2019, MICROORGANISMS, V7, DOI 10.3390/microorganisms7090320
   Bashir Farhat, 2017, J Ayub Med Coll Abbottabad, V29, P604
   Bergamo P, 2014, J FUNCT FOODS, V11, P192, DOI 10.1016/j.jff.2014.10.007
   Bjermo H, 2012, AM J CLIN NUTR, V95, P1003, DOI 10.3945/ajcn.111.030114
   Boden G, 2002, EUR J CLIN INVEST, V32, P14, DOI 10.1046/j.1365-2362.32.s3.3.x
   BONORA E, 1984, CURR MED RES OPIN, V9, P47, DOI 10.1185/03007998409109558
   Brown LCW, 2013, PLOS BIOL, V11, DOI 10.1371/journal.pbio.1001610
   Brunkwall L, 2017, DIABETOLOGIA, V60, P943, DOI 10.1007/s00125-017-4278-3
   Chang CJ, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms8489
   Chen YM, 2016, SCI REP-UK, V6, DOI 10.1038/srep19076
   Codella R, 2018, DIGEST LIVER DIS, V50, P331, DOI 10.1016/j.dld.2017.11.016
   David LA, 2014, NATURE, V505, P559, DOI 10.1038/nature12820
   Egom EEA, 2012, EXPERT OPIN THER TAR, V16, P791, DOI 10.1517/14728222.2012.699043
   Flint HJ, 2015, P NUTR SOC, V74, P13, DOI 10.1017/S0029665114001463
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Furet JP, 2010, DIABETES, V59, P3049, DOI 10.2337/db10-0253
   Gao ZG, 2009, DIABETES, V58, P1509, DOI 10.2337/db08-1637
   Garcia-Villalba R, 2012, J SEP SCI, V35, P1906, DOI 10.1002/jssc.201101121
   Ghosh Debosree, 2016, Curr Drug Discov Technol, V13, P60
   Guo JH, 2013, ONCOL LETT, V5, P1572, DOI 10.3892/ol.2013.1261
   Harazaki T, 2014, NUTRITION, V30, P590, DOI 10.1016/j.nut.2013.10.020
   Hassan N.K., CLIN REV NUTR REQUIR
   Huang Q, 2013, CANCER RES, V73, P4992, DOI 10.1158/0008-5472.CAN-13-0308
   Hussain M, 2016, JAMC, V28, P369
   Jiang H, 2015, SCI REP-UK, V5, DOI 10.1038/srep15599
   Kaczmarczyk MM, 2012, METABOLISM, V61, P1058, DOI 10.1016/j.metabol.2012.01.017
   Kakiyama G, 2013, J HEPATOL, V58, P949, DOI 10.1016/j.jhep.2013.01.003
   Kamada N, 2013, NAT REV IMMUNOL, V13, P321, DOI 10.1038/nri3430
   Keenan MJ, 2015, ADV NUTR, V6, P198, DOI 10.3945/an.114.007419
   Kohli R, 2010, AM J PHYSIOL-GASTR L, V299, pG652, DOI 10.1152/ajpgi.00221.2010
   Koppel N, 2017, SCIENCE, V356, DOI 10.1126/science.aag2770
   Kovatcheva-Datchary P, 2015, CELL METAB, V22, P971, DOI 10.1016/j.cmet.2015.10.001
   Kuczynski Justin, 2011, Curr Protoc Bioinformatics, VChapter 10, DOI [10.1002/9780471729259.mc01e05s27, 10.1002/0471250953.bi1007s36]
   Kurotani K, 2012, NUTR RES, V32, P669, DOI 10.1016/j.nutres.2012.07.004
   Laurans L, 2018, NAT MED, V24, P1113, DOI 10.1038/s41591-018-0060-4
   Le Chatelier E, 2013, NATURE, V500, P541, DOI 10.1038/nature12506
   Le Kim D, 1976, Hoppe Seylers Z Physiol Chem, V357, P1321, DOI 10.1515/bchm2.1976.357.2.1321
   Luo JB, 2014, FISH SHELLFISH IMMUN, V40, P197, DOI 10.1016/j.fsi.2014.07.003
   Mao XH, 2018, FOOD HYDROCOLLOID, V85, P21, DOI 10.1016/j.foodhyd.2018.06.036
   Musso G, 2011, ANNU REV MED, V62, P361, DOI 10.1146/annurev-med-012510-175505
   Ogurtsova K, 2017, DIABETES RES CLIN PR, V128, P40, DOI 10.1016/j.diabres.2017.03.024
   Ordovas JM, 2006, CURR OPIN LIPIDOL, V17, P157, DOI 10.1097/01.mol.0000217897.75068.ba
   Plain KM, 2011, INFECT IMMUN, V79, P3821, DOI 10.1128/IAI.05204-11
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Qu YY, 2020, CANCER RES, V80, P319, DOI 10.1158/0008-5472.CAN-19-1023
   Raigond P, 2015, J SCI FOOD AGR, V95, P1968, DOI 10.1002/jsfa.6966
   Remely M, 2014, BENEF MICROBES, V5, P33, DOI 10.3920/BM2013.006
   Remely M, 2016, ENDOCR METAB IMMUNE, V16, P99, DOI 10.2174/1871530316666160831093813
   Ren XL, 2016, BIOMED CHROMATOGR, V30, P68, DOI 10.1002/bmc.3620
   Ribet D, 2015, MICROBES INFECT, V17, P173, DOI 10.1016/j.micinf.2015.01.004
   Robertson MD, 2012, CURR OPIN CLIN NUTR, V15, P362, DOI 10.1097/MCO.0b013e3283536931
   Santacruz A, 2010, BRIT J NUTR, V104, P83, DOI 10.1017/S0007114510000176
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Simon MC, 2020, J BIOL CHEM, V295, P969, DOI 10.1074/jbc.RA119.010816
   Tremaroli V, 2012, NATURE, V489, P242, DOI 10.1038/nature11552
   Ussher JR, 2014, EXPERT REV CARDIOVAS, V12, P345, DOI 10.1586/14779072.2014.891939
   Wakabayashi I, 2014, J ATHEROSCLER THROMB, V21, P282, DOI 10.5551/jat.20628
   Wang CG, 2018, MOLECULES, V23, DOI 10.3390/molecules23061315
   Wang J., 2013, HEART, V99
   Wang LL, 2019, TRENDS BIOTECHNOL, V37, P492, DOI 10.1016/j.tibtech.2018.10.003
   Wang ZN, 2011, NATURE, V472, P57, DOI 10.1038/nature09922
   Wang Z, 2016, CURR OPIN LIPIDOL, V27, P216, DOI 10.1097/MOL.0000000000000308
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Wu TR, 2019, GUT, V68, P248, DOI 10.1136/gutjnl-2017-315458
   Xu LN, 2018, PHARMACOL RES, V130, P451, DOI 10.1016/j.phrs.2018.01.015
   Zhang CJ, 2019, BIOMED PHARMACOTHER, V109, P2270, DOI 10.1016/j.biopha.2018.11.119
   Zhang FH, 2019, ENDOCRINE, V66, P485, DOI 10.1007/s12020-019-02041-5
   Zhang SH, 2017, J ANIM SCI BIOTECHNO, V8, DOI 10.1186/s40104-016-0139-z
   Zhao LP, 2018, SCIENCE, V359, P1151, DOI 10.1126/science.aao5774
   Zheng SQ, 2019, J CHEM INF MODEL, V59, P1215, DOI 10.1021/acs.jcim.8b00600
   Zhou ZK, 2015, INT J BIOL MACROMOL, V75, P316, DOI 10.1016/j.ijbiomac.2015.01.052
   Zong G, 2019, DIABETES CARE, V42, P1406, DOI 10.2337/dc19-0412
NR 74
TC 21
Z9 22
U1 18
U2 82
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-6618
EI 1096-1186
J9 PHARMACOL RES
JI Pharmacol. Res.
PD SEP
PY 2020
VL 159
AR 104985
DI 10.1016/j.phrs.2020.104985
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA NK0NE
UT WOS:000566437600020
PM 32504839
DA 2023-06-08
ER

PT J
AU Wang, DM
   Liu, JY
   Zhou, LY
   Zhang, Q
   Li, M
   Xiao, XH
AF Wang, Dongmei
   Liu, Jieying
   Zhou, Liyuan
   Zhang, Qian
   Li, Ming
   Xiao, Xinhua
TI Effects of Oral Glucose-Lowering Agents on Gut Microbiota and Microbial
   Metabolites
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE gut microbiota; microbial metabolites; T2DM; antidiabetic drugs; SCFA
ID DIABETES-MELLITUS; INTESTINAL MICROBIOTA; DOUBLE-BLIND; BODY-WEIGHT;
   METFORMIN; OBESITY; MODULATION; BACTERIA; INFLAMMATION; DYSLIPIDEMIA
AB The current research and existing facts indicate that type 2 diabetes mellitus (T2DM) is characterized by gut microbiota dysbiosis and disturbed microbial metabolites. Oral glucose-lowering drugs are reported with pleiotropic beneficial effects, including not only a decrease in glucose level but also weight loss, antihypertension, anti-inflammation, and cardiovascular protection, but the underlying mechanisms are still not clear. Evidence can be found showing that oral glucose-lowering drugs might modify the gut microbiome and thereby alter gastrointestinal metabolites to improve host health. Although the connections among gut microbial communities, microbial metabolites, and T2DM are complex, figuring out how antidiabetic agents shape the gut microbiome is vital for optimizing the treatment, meaningful for the instruction for probiotic therapy and gut microbiota transplantation in T2DM. In this review, we focused on the literatures in gut microbiota and its metabolite profile alterations beneficial from oral antidiabetic drugs, trying to provide implications for future study in the developing field of these drugs, such as combination therapies, pre- and probiotics intervention in T2DM, and subjects with pregestational diabetes and gestational diabetes mellitus.
C1 [Wang, Dongmei; Liu, Jieying; Zhou, Liyuan; Zhang, Qian; Li, Ming; Xiao, Xinhua] Chinese Acad Med Sci, Peking Union Med Coll Hosp, Peking Union Med Coll, Dept Endocrinol, Beijing, Peoples R China.
   [Liu, Jieying] Chinese Acad Med Sci, Peking Union Med Coll Hosp, Peking Union Med Coll, Dept Med Res Ctr, Beijing, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College; Peking Union Medical College Hospital;
   Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College; Peking Union Medical College Hospital
RP Xiao, XH (通讯作者)，Chinese Acad Med Sci, Peking Union Med Coll Hosp, Peking Union Med Coll, Dept Endocrinol, Beijing, Peoples R China.
EM xiaoxh2014@vip.163.com
RI Liu, Jieying/ADZ-7556-2022; Li, Ming/I-1323-2018
OI Li, Ming/0000-0002-8427-605X
FU National Natural Science Foundation of China [82170854, 81870579,
   81870545, 81570715, 81170736]; Beijing Natural Science Foundation
   [7202163]; Beijing Municipal Science & Technology Commission
   [Z201100005520011]; CAMS Innovation Fund for Medical Sciences
   [CIFMS2021-1-I2M-002]
FX Funding This work was supported by the grants from the National Natural
   Science Foundation of China (No. 82170854, 81870579, 81870545, 81570715,
   81170736), Beijing Natural Science Foundation (7202163), Beijing
   Municipal Science & Technology Commission (Z201100005520011), CAMS
   Innovation Fund for Medical Sciences (CIFMS2021-1-I2M-002).
CR Abboud M, 2021, NUTRIENTS, V13, DOI 10.3390/nu13010111
   Aggarwal H, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23010195
   Agus A, 2021, GUT, V70, P1174, DOI 10.1136/gutjnl-2020-323071
   Ahmadi S, 2020, J GERONTOL A-BIOL, V75, pE9, DOI 10.1093/gerona/glaa056
   Ahmadian M, 2013, NAT MED, V19, P557, DOI 10.1038/nm.3159
   Al Kattar S, 2020, CANCERS, V12, DOI 10.3390/cancers12071857
   Amer Diabet Assoc, 2021, DIABETES CARE, V44, pS111, DOI 10.2337/dc21-S009
   Arpaia N, 2013, NATURE, V504, P451, DOI 10.1038/nature12726
   Balaich J, 2021, NATURE, V600, P110, DOI 10.1038/s41586-021-04091-0
   Ballan R, 2021, FOODS, V10, DOI 10.3390/foods10112528
   Barengolts E, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0194171
   Baxter NT, 2019, MSPHERE, V4, DOI [10.1128/mSphere.00528-18, 10.1128/msphere.00528-18]
   Bennis Y, 2020, CRIT CARE MED, V48, pE1194, DOI 10.1097/CCM.0000000000004589
   Tonucci L, 2017, CRIT REV FOOD SCI, V57, P2296, DOI 10.1080/10408398.2014.934438
   Bryrup T, 2019, DIABETOLOGIA, V62, P1024, DOI 10.1007/s00125-019-4848-7
   Burton Jeffrey H, 2015, J Diabetes Sci Technol, V9, P808, DOI 10.1177/1932296815577425
   Callaway LK, 2019, DIABETES CARE, V42, P364, DOI 10.2337/dc18-2248
   Canfora EE, 2019, NAT REV ENDOCRINOL, V15, P261, DOI 10.1038/s41574-019-0156-z
   Carvalho BM, 2012, DIABETOLOGIA, V55, P2823, DOI 10.1007/s00125-012-2648-4
   Chavez-Talavera O, 2017, GASTROENTEROLOGY, V152, P1679, DOI 10.1053/j.gastro.2017.01.055
   Chen B, 2020, ENDOCRINE, V68, P564, DOI 10.1007/s12020-020-02269-6
   Chen ML, 2017, J AM HEART ASSOC, V6, DOI 10.1161/JAHA.117.006347
   Chen SF, 2019, CELL METAB, V30, P1141, DOI 10.1016/j.cmet.2019.08.021
   Chen X, 2021, FRONT BIOENG BIOTECH, V9, DOI 10.3389/fbioe.2021.694100
   Chimerel C, 2014, CELL REP, V9, P1202, DOI 10.1016/j.celrep.2014.10.032
   Cowie MR, 2020, NAT REV CARDIOL, V17, P761, DOI 10.1038/s41569-020-0406-8
   Dalile B, 2019, NAT REV GASTRO HEPAT, V16, P461, DOI 10.1038/s41575-019-0157-3
   Danic M, 2021, EUR J PHARM SCI, V158, DOI 10.1016/j.ejps.2020.105668
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Deeks ED, 2006, DRUGS, V66, P1863, DOI 10.2165/00003495-200666140-00007
   Deeks ED, 2022, DRUGS, V82, P87, DOI 10.1007/s40265-021-01648-1
   Deng XR, 2022, J CLIN ENDOCR METAB, V107, P1888, DOI 10.1210/clinem/dgac210
   Denou E, 2016, AM J PHYSIOL-ENDOC M, V310, pE982, DOI 10.1152/ajpendo.00537.2015
   Ding DF, 2022, FRONT CELL INFECT MI, V12, DOI 10.3389/fcimb.2022.820367
   Dirir AM, 2022, PHYTOCHEM REV, V21, P1049, DOI 10.1007/s11101-021-09773-1
   Do HJ, 2016, ENDOCR J, V63, P691, DOI 10.1507/endocrj.EJ15-0747
   Dubourg J, 2022, DIABETES OBES METAB, V24, P609, DOI 10.1111/dom.14613
   Dubourg J, 2021, DIABETES CARE, V44, P952, DOI 10.2337/dc20-0763
   Fang WY, 2021, BRIT J PHARMACOL, V178, P2998, DOI 10.1111/bph.15472
   Ferguson D, 2021, NAT REV ENDOCRINOL, V17, P484, DOI 10.1038/s41574-021-00507-z
   Foretz M, 2019, NAT REV ENDOCRINOL, V15, P569, DOI 10.1038/s41574-019-0242-2
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Galligan JJ, 2018, NEUROGASTROENT MOTIL, V30, DOI 10.1111/nmo.13283
   Gomes JMG, 2017, METABOLISM, V68, P133, DOI 10.1016/j.metabol.2016.12.009
   Gou WL, 2021, DIABETES CARE, V44, P358, DOI 10.2337/dc20-1536
   Gregg EW, 2016, LANCET DIABETES ENDO, V4, P537, DOI 10.1016/S2213-8587(16)30010-9
   Gu YY, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-01682-2
   Guo YJ, 2021, EUR J NUTR, V60, P2217, DOI 10.1007/s00394-020-02414-x
   Gurung M, 2020, EBIOMEDICINE, V51, DOI 10.1016/j.ebiom.2019.11.051
   Haal S, 2021, LANCET GASTROENTEROL, V6, P993, DOI 10.1016/S2468-1253(21)00301-0
   Hallakou-Bozec S, 2021, DIABETES OBES METAB, V23, P664, DOI 10.1111/dom.14277
   Hanssen NMJ, 2021, CELL METAB, V33, P1098, DOI 10.1016/j.cmet.2021.05.005
   Hartstra AV, 2015, DIABETES CARE, V38, P159, DOI 10.2337/dc14-0769
   He L, 2020, TRENDS PHARMACOL SCI, V41, P868, DOI 10.1016/j.tips.2020.09.001
   Heianza Y, 2017, J AM HEART ASSOC, V6, DOI 10.1161/JAHA.116.004947
   Hu N, 2022, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.794103
   Huang F, 2018, INT J FOOD SCI NUTR, V69, P729, DOI 10.1080/09637486.2017.1408059
   Huang LL, 2021, EUR J NUTR, V60, P2343, DOI 10.1007/s00394-021-02483-6
   Huo TG, 2015, BIOMED CHROMATOGR, V29, P115, DOI 10.1002/bmc.3247
   Jandhyala SM, 2015, WORLD J GASTROENTERO, V21, P8787, DOI 10.3748/wjg.v21.i29.8787
   Jia JZ, 2019, DIABETES, V68, P1747, DOI 10.2337/db19-0153
   Jiao N, 2018, GUT, V67, P1881, DOI 10.1136/gutjnl-2017-314307
   Just S, 2018, MICROBIOME, V6, DOI 10.1186/s40168-018-0510-8
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kato T, 2018, NUTRIENTS, V10, DOI 10.3390/nu10030340
   Kimura I, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms2852
   Kishida Y, 2017, J GASTROENTEROL, V52, P1180, DOI 10.1007/s00535-017-1331-4
   Kondo Y, 2021, NUTRIENTS, V13, DOI 10.3390/nu13113816
   Krautkramer KA, 2021, NAT REV MICROBIOL, V19, P77, DOI 10.1038/s41579-020-0438-4
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Lazarus B, 2018, JAMA INTERN MED, V178, P903, DOI 10.1001/jamainternmed.2018.0292
   Lee DM, 2018, CARDIOVASC DIABETOL, V17, DOI 10.1186/s12933-018-0708-x
   Lee Y, 2021, DIABETES RES CLIN PR, V178, DOI 10.1016/j.diabres.2021.108985
   Lefebvre AM, 1999, J ENDOCRINOL, V162, P331, DOI 10.1677/joe.0.1620331
   Ley RE, 2006, NATURE, V444, P1022, DOI 10.1038/4441022a
   Li JM, 2019, MICROBIOME, V7, DOI 10.1186/s40168-019-0713-7
   Li J, 2022, DIABETES, V71, P424, DOI 10.2337/db21-0123
   Li LY, 2018, CURR PHARM DESIGN, V24, P3223, DOI 10.2174/1381612824666180912143434
   Li PP, 2006, BRIT J PHARMACOL, V148, P610, DOI 10.1038/sj.bjp.0706745
   Li SC, 2021, J MICROBIOL, V59, P693, DOI 10.1007/s12275-021-0454-8
   Li W, 2019, J DIABETES, V11, P982, DOI 10.1111/1753-0407.12956
   Li ZR, 2021, INT J BIOL MACROMOL, V170, P447, DOI 10.1016/j.ijbiomac.2020.12.126
   Liao XY, 2019, EBIOMEDICINE, V44, P665, DOI 10.1016/j.ebiom.2019.03.057
   Liu Y, 2020, CELL METAB, V31, P77, DOI 10.1016/j.cmet.2019.11.001
   Liu ZY, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.640347
   Lozupone CA, 2012, NATURE, V489, P220, DOI 10.1038/nature11550
   Lv ZQ, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.00191
   Madiraju AK, 2018, NAT MED, V24, P1384, DOI 10.1038/s41591-018-0125-4
   Madsen MSA, 2021, BIOMED PHARMACOTHER, V133, DOI 10.1016/j.biopha.2020.110966
   Magne F, 2020, NUTRIENTS, V12, DOI 10.3390/nu12051474
   Martin-Gallausiaux C, 2021, P NUTR SOC, V80, P37, DOI 10.1017/S0029665120006916
   McCreight LJ, 2016, DIABETOLOGIA, V59, P426, DOI 10.1007/s00125-015-3844-9
   McIntyre HD, 2019, NAT REV DIS PRIMERS, V5, DOI 10.1038/s41572-019-0098-8
   Medina-Vera I, 2019, DIABETES METAB, V45, P122, DOI 10.1016/j.diabet.2018.09.004
   Miao M, 2022, FRONT MICROBIOL, V13, DOI 10.3389/fmicb.2022.832151
   Mishima E, 2018, AM J PHYSIOL-RENAL, V315, pF824, DOI 10.1152/ajprenal.00314.2017
   Molina-Vega M, 2022, BIOMED PHARMACOTHER, V145, DOI 10.1016/j.biopha.2021.112465
   Mueller NT, 2021, DIABETES CARE, V44, P1462, DOI 10.2337/dc20-2257
   Napolitano A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100778
   Nepal MR, 2020, DIABETES METAB J, V44, P908, DOI 10.4093/dmj.2019.0147
   Ng SC, 2022, GUT, V71, P716, DOI 10.1136/gutjnl-2020-323617
   Oh TJ, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-56684-5
   Olivares M, 2018, DIABETOLOGIA, V61, P1838, DOI 10.1007/s00125-018-4647-6
   Org E, 2017, GENOME BIOL, V18, DOI 10.1186/s13059-017-1194-2
   Osataphan S, 2019, JCI INSIGHT, V4, DOI 10.1172/jci.insight.123130
   Palacios T, 2020, NUTRIENTS, V12, DOI 10.3390/nu12072041
   Panwar H, 2014, EUR J NUTR, V53, P1465, DOI 10.1007/s00394-013-0649-9
   Patnode ML, 2019, CELL, V179, P59, DOI 10.1016/j.cell.2019.08.011
   Pedersen C, 2016, BRIT J NUTR, V116, P1869, DOI 10.1017/S0007114516004086
   Pedersen HK, 2016, NATURE, V535, P376, DOI 10.1038/nature18646
   Perkovic V., 2019, NEW ENGL J MED, V380, P2295, DOI [DOI 10.1056/NEJMOA1811744, 10.1056/NEJMoa1811744]
   Perreault L, 2021, NAT REV ENDOCRINOL, V17, P364, DOI 10.1038/s41574-021-00489-y
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Ratajczak W, 2019, ACTA BIOCHIM POL, V66, P1, DOI 10.18388/abp.2018_2648
   Romano KA, 2015, MBIO, V6, DOI 10.1128/mBio.02481-14
   Ryan PM, 2020, CAN J DIABETES, V44, P146, DOI 10.1016/j.jcjd.2019.05.008
   Saad MJA, 2016, PHYSIOLOGY, V31, P283, DOI 10.1152/physiol.00041.2015
   Salgaco MK, 2019, APPL MICROBIOL BIOT, V103, P9229, DOI 10.1007/s00253-019-10156-y
   Scheen AJ, 2021, DIABETES METAB, V47, DOI 10.1016/j.diabet.2020.11.001
   Schonfeld P, 2016, J LIPID RES, V57, P943, DOI 10.1194/jlr.R067629
   Schwientek P, 2012, BMC GENOMICS, V13, DOI 10.1186/1471-2164-13-112
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Silva-Veiga FM, 2020, J ENDOCRINOL, V247, P11, DOI 10.1530/JOE-20-0139
   Simpson BW, 2019, NAT REV MICROBIOL, V17, P403, DOI 10.1038/s41579-019-0201-x
   Smith BJ, 2021, MSPHERE, V6, DOI 10.1128/msphere.00851-21
   Smith BJ, 2019, BMC MICROBIOL, V19, DOI 10.1186/s12866-019-1494-7
   Smits MM, 2021, DIABETES METAB, V47, DOI 10.1016/j.diabet.2021.101223
   Smits MM, 2016, DIABETES OBES METAB, V18, P1217, DOI 10.1111/dom.12748
   Snelson M, 2021, BEST PRACT RES CL EN, V35, DOI 10.1016/j.beem.2021.101507
   Sommer F, 2013, NAT REV MICROBIOL, V11, P227, DOI 10.1038/nrmicro2974
   Stumvoll M, 2005, LANCET, V365, P1333, DOI 10.1016/S0140-6736(05)61032-X
   Su BL, 2015, J DIABETES, V7, P729, DOI 10.1111/1753-0407.12232
   Su LL, 2022, SCI REP-UK, V12, DOI 10.1038/s41598-022-05127-9
   Sun H, 2022, DIABETES RES CLIN PR, V183, DOI 10.1016/j.diabres.2021.109119
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Takewaki F, 2021, NUTRIENTS, V13, DOI 10.3390/nu13062107
   Tan KM, 2018, PROTEIN SCI, V27, P1498, DOI 10.1002/pro.3444
   Taylor BL, 2017, NUTRIENTS, V9, DOI 10.3390/nu9050461
   Thirunavukarasu S, 2021, DIABETES, V70, P2810, DOI 10.2337/db21-0270
   Thomas C, 2009, CELL METAB, V10, P167, DOI 10.1016/j.cmet.2009.08.001
   Thornberry NA, 2009, BEST PRACT RES CL EN, V23, P479, DOI 10.1016/j.beem.2009.03.004
   Tilg H, 2014, GUT, V63, P1513, DOI 10.1136/gutjnl-2014-306928
   Tong XL, 2018, MBIO, V9, DOI 10.1128/mBio.02392-17
   Toulis KA, 2020, DRUGS, V80, P467, DOI 10.1007/s40265-020-01278-z
   Turnbaugh PJ, 2007, NATURE, V449, P804, DOI 10.1038/nature06244
   van Bommel EJM, 2020, DIABETES METAB, V46, P164, DOI 10.1016/j.diabet.2019.11.005
   Vangipurapu J, 2020, DIABETES CARE, V43, P1319, DOI 10.2337/dc19-2533
   Velasquez MT, 2016, TOXINS, V8, DOI 10.3390/toxins8110326
   Venkatesh M, 2014, IMMUNITY, V41, P296, DOI 10.1016/j.immuni.2014.06.014
   Walters WA, 2014, FEBS LETT, V588, P4223, DOI 10.1016/j.febslet.2014.09.039
   Wang L, 2016, SCI REP-UK, V6, DOI [10.1038/srep38380, 10.1038/srep33251, 10.1038/srep20004]
   Wang Y, 2018, J EXP CLIN CANC RES, V37, DOI 10.1186/s13046-018-0731-5
   Wang YM, 2022, DIABETES RES CLIN PR, V183, DOI 10.1016/j.diabres.2021.109171
   Wang ZC, 2021, LIFE SCI, V274, DOI 10.1016/j.lfs.2021.119069
   Wiviott SD, 2019, NEW ENGL J MED, V380, P347, DOI 10.1056/NEJMoa1812389
   Wu H, 2020, CELL METAB, V32, P379, DOI 10.1016/j.cmet.2020.06.011
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Yamaguchi Y, 2016, DIGESTION, V94, P66, DOI 10.1159/000447690
   Yan XF, 2016, J DIABETES RES, V2016, DOI 10.1155/2016/2093171
   Yang H, 2018, BRIT J PHARMACOL, V175, P3610, DOI 10.1111/bph.14434
   Yang M, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.00635
   Yang WJ, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-18262-6
   Yao Y, 2020, PHYTOMEDICINE, V77, DOI 10.1016/j.phymed.2020.153268
   Yurista SR, 2021, J AM COLL CARDIOL, V77, P1660, DOI 10.1016/j.jacc.2020.12.065
   Zhang FH, 2019, ENDOCRINE, V66, P485, DOI 10.1007/s12020-019-02041-5
   Zhang HW, 2021, FOOD FUNCT, V12, P10783, DOI [10.1039/d1fo02517a, 10.1039/D1FO02517A]
   Zhang LS, 2020, FRONT PHARMACOL, V10, DOI 10.3389/fphar.2019.01684
   Zhang MC, 2019, BMJ OPEN DIAB RES CA, V7, DOI 10.1136/bmjdrc-2019-000717
   Zhang PP, 2020, ACTA PHARMACOL SIN, V41, P678, DOI 10.1038/s41401-019-0330-9
   Zhang Q, 2018, PEERJ, V6, DOI 10.7717/peerj.4446
   Zhang Q, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0184735
   Zhang W, 2019, BIOMED PHARMACOTHER, V118, DOI 10.1016/j.biopha.2019.109131
   Zhang YL, 2021, J ETHNOPHARMACOL, V274, DOI 10.1016/j.jep.2021.114033
   Zhao LP, 2018, SCIENCE, V359, P1151, DOI 10.1126/science.aao5774
   Zhu YQ, 2021, EUR J MED CHEM, V223, DOI 10.1016/j.ejmech.2021.113665
NR 175
TC 6
Z9 6
U1 5
U2 10
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD JUL 13
PY 2022
VL 13
AR 905171
DI 10.3389/fendo.2022.905171
PG 16
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 6I2QI
UT WOS:000885974600001
PM 35909556
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Deehan, EC
   Colin-Ramirez, E
   Triador, L
   Madsen, KL
   Prado, CM
   Field, CJ
   Ball, GDC
   Tan, QM
   Orsso, C
   Dinu, I
   Pakseresht, M
   Rubin, D
   Sharma, AM
   Tun, H
   Walter, J
   Newgard, CB
   Freemark, M
   Wine, E
   Haqq, AM
AF Deehan, Edward C.
   Colin-Ramirez, Eloisa
   Triador, Lucila
   Madsen, Karen L.
   Prado, Carla M.
   Field, Catherine J.
   Ball, Geoff D. C.
   Tan, Qiming
   Orsso, Camila
   Dinu, Irina
   Pakseresht, Mohammadreza
   Rubin, Daniela
   Sharma, Arya M.
   Tun, Hein
   Walter, Jens
   Newgard, Christopher B.
   Freemark, Michael
   Wine, Eytan
   Haqq, Andrea M.
TI Efficacy of metformin and fermentable fiber combination therapy in
   adolescents with severe obesity and insulin resistance: study protocol
   for a double-blind randomized controlled trial
SO TRIALS
LA English
DT Article
DE Adolescents; Insulin resistance; Diabetes; Obesity; Metformin; Dietary
   fiber; Gut microbiome
ID PHYSICAL-ACTIVITY QUESTIONNAIRE; HOMEOSTASIS MODEL ASSESSMENT; ORAL
   GLUCOSE-TOLERANCE; INFANT GUT MICROBIOTA; DIETARY FIBER;
   WAIST-CIRCUMFERENCE; SENSITIVITY; CHILDREN; VALIDITY; VALIDATION
AB BackgroundAccumulating evidence suggests that the metabolic effects of metformin and fermentable fibers are mediated, in part, through diverging or overlapping effects on the composition and metabolic functions of the gut microbiome. Pre-clinical animal models have established that the addition of fiber to metformin monotherapy improves glucose tolerance. However, possible synergistic effects of combination therapy (metformin plus fiber) have not been investigated in humans. Moreover, the underlying mechanisms of synergy have yet to be elucidated. The aim of this study is to compare in adolescents with obesity the metabolic effects of metformin and fermentable fibers in combination with those of metformin or fiber alone. We will also determine if therapeutic responses correlate with compositional and functional features of the gut microbiome.MethodsThis is a parallel three-armed, double-blinded, randomized controlled trial. Adolescents (aged 12-18years) with obesity, insulin resistance (IR), and a family history of type 2 diabetes mellitus (T2DM) will receive either metformin (850mg p.o. twice/day), fermentable fibers (35g/day), or a combination of metformin plus fiber for 12months. Participants will be seen at baseline, 3, 6, and 12months, with a phone follow-up at 1 and 9months. Primary and secondary outcomes will be assessed at baseline, 6, and 12months. The primary outcome is change in IR estimated by homeostatic model assessment of IR; key secondary outcomes include changes in the Matsuda index, oral disposition index, body mass index z-score, and fat mass to fat-free mass ratio. To gain mechanistic insight, endpoints that reflect host-microbiota interactions will also be assessed: obesity-related immune, metabolic, and satiety markers; humoral metabolites; and fecal microbiota composition, short-chain fatty acids, and bile acids.DiscussionThis study will compare the potential metabolic benefits of fiber with those of metformin in adolescents with obesity, determine if metformin and fiber act synergistically to improve IR, and elucidate whether the metabolic benefits of metformin and fiber associate with changes in fecal microbiota composition and the output of health-related metabolites. This study will provide insight into the potential role of the gut microbiome as a target for enhancing the therapeutic efficacy of emerging treatments for T2DM prevention.Trial registrationClinicalTrials.gov NCT04578652. Registered on 8 October 2020.
C1 [Deehan, Edward C.; Prado, Carla M.; Field, Catherine J.; Orsso, Camila; Pakseresht, Mohammadreza] Univ Alberta, Dept Agr Food & Nutr Sci, Edmonton, AB T6G 2E1, Canada.
   [Colin-Ramirez, Eloisa; Triador, Lucila; Ball, Geoff D. C.; Tan, Qiming; Haqq, Andrea M.] Univ Alberta, Dept Pediat, Edmonton, AB T6G 2E1, Canada.
   [Madsen, Karen L.; Sharma, Arya M.] Univ Alberta, Dept Med, Edmonton, AB T6G 2C2, Canada.
   [Dinu, Irina] Univ Alberta, Sch Publ Hlth, Edmonton, AB T6G 1C9, Canada.
   [Rubin, Daniela] Calif State Univ Fullerton, Fullerton, CA 92634 USA.
   [Tun, Hein] Univ Hong Kong, Sch Publ Hlth, Hong Kong, Peoples R China.
   [Walter, Jens] Univ Coll Cork, DNatl Univ Ireland Univ Coll Cork, Cork, Ireland.
   [Newgard, Christopher B.; Freemark, Michael] Duke Univ, Med Ctr, Duke Univ Hosp, Durham, NC USA.
   [Wine, Eytan] Univ Alberta, Dept Pediat & Physiol, Edmonton, AB T6G 1C9, Canada.
C3 University of Alberta; University of Alberta; University of Alberta;
   University of Alberta; California State University System; California
   State University Fullerton; University of Hong Kong; University College
   Cork; Duke University; University of Alberta
RP Haqq, AM (通讯作者)，Univ Alberta, Dept Pediat, Edmonton, AB T6G 2E1, Canada.
EM haqq@ualberta.ca
RI Madsen, Karen L/H-5898-2011; Walter, Jens/AAA-7636-2020; Deehan, Edward
   C./ABF-6669-2020; RUBIN, DANIELA/AAC-4206-2022; Tun, Hein/ACR-0815-2022
OI Walter, Jens/0000-0003-1754-172X; Deehan, Edward C./0000-0001-7697-1418;
   Tun, Hein/0000-0001-7597-5062; Tan, Qiming/0000-0001-9014-6246;
   Colin-Ramirez, Eloisa/0000-0003-2998-1239
FU The W. Garfield Weston Foundation
FX This work is funded by The W. Garfield Weston Foundation (without
   project number). The UofA and The W. Garfield Weston Foundation will not
   intervene in any aspect of the trial, including its design, data
   collection, analysis, or presentation.
CR Ahmad TR, 2019, NAT REV ENDOCRINOL, V15, P701, DOI 10.1038/s41574-019-0266-7
   Allin KH, 2018, DIABETOLOGIA, V61, P810, DOI 10.1007/s00125-018-4550-1
   [Anonymous], GUIDANCE DOCUMENT CL
   Armet AM, 2020, ADV NUTR, V11, P420, DOI 10.1093/advances/nmz074
   Aroda VR, 2016, J CLIN ENDOCR METAB, V101, P1754, DOI 10.1210/jc.2015-3754
   Arrieta MC, 2018, J ALLERGY CLIN IMMUN, V142, P424, DOI 10.1016/j.jaci.2017.08.041
   Arumugam M, 2011, NATURE, V473, P174, DOI 10.1038/nature09944
   Blaak EE, 2020, BENEF MICROBES, V11, P411, DOI 10.3920/BM2020.0057
   Bolyen E, 2019, NAT BIOTECHNOL, V37, P852, DOI 10.1038/s41587-019-0209-9
   Bonora E, 2000, DIABETES CARE, V23, P57, DOI 10.2337/diacare.23.1.57
   Burton Jeffrey H, 2015, J Diabetes Sci Technol, V9, P808, DOI 10.1177/1932296815577425
   Cardello AV, 2005, APPETITE, V44, P1, DOI 10.1016/j.appet.2004.05.007
   Chung WSF, 2019, FEMS MICROBIOL ECOL, V95, DOI 10.1093/femsec/fiy201
   Clarson CL, 2009, ENDOCRINE, V36, P141, DOI 10.1007/s12020-009-9196-9
   Costea PI, 2017, NAT BIOTECHNOL, V35, P1069, DOI 10.1038/nbt.3960
   Dao MC, 2016, GUT, V65, P426, DOI 10.1136/gutjnl-2014-308778
   De Vadder F, 2014, CELL, V156, P84, DOI 10.1016/j.cell.2013.12.016
   Deehan EC, 2020, CELL HOST MICROBE, V27, P389, DOI 10.1016/j.chom.2020.01.006
   Deehan EC, 2017, MICROBIOL SPECTR, V5, DOI 10.1128/microbiolspec.BAD-0019-2017
   Del Chierico F, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.01210
   DEMPSTER P, 1995, MED SCI SPORT EXER, V27, P1692
   Depommier C, 2019, NAT MED, V25, P1096, DOI 10.1038/s41591-019-0495-2
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Fintini D, 2016, NUTR METAB CARDIOVAS, V26, P842, DOI 10.1016/j.numecd.2016.05.010
   Flint HJ, 2017, CURR OPIN MICROBIOL, V38, P59, DOI 10.1016/j.mib.2017.04.005
   Foretz M, 2014, CELL METAB, V20, P953, DOI 10.1016/j.cmet.2014.09.018
   Freemark M, 2001, PEDIATRICS, V107, DOI 10.1542/peds.107.4.e55
   Gomes JMG, 2017, METABOLISM, V68, P133, DOI 10.1016/j.metabol.2016.12.009
   Grabitske H, 2009, CRIT REV FOOD SCI, V49, P327, DOI 10.1080/10408390802067126
   Grooms KN, 2013, AM J MED, V126, P1059, DOI 10.1016/j.amjmed.2013.07.023
   Gungor N, 2004, J PEDIATR-US, V144, P47, DOI 10.1016/j.jpeds.2003.09.045
   Hamman RF, 2014, DIABETES CARE, V37, P3336, DOI 10.2337/dc14-0574
   Harris PA, 2009, J BIOMED INFORM, V42, P377, DOI 10.1016/j.jbi.2008.08.010
   Haymond M, 2007, PEDIATR DIABETES, V8, P74
   Healey GR, 2017, NUTR REV, V75, P1059, DOI 10.1093/nutrit/nux062
   Hjorth MF, 2019, INT J OBESITY, V43, P149, DOI 10.1038/s41366-018-0093-2
   Jensen ET, 2018, CURR DIABETES REP, V18, DOI 10.1007/s11892-018-0997-1
   John GK, 2016, CURR ONCOL REP, V18, DOI 10.1007/s11912-016-0528-7
   Johnson ST, 2010, J PEDIATR-US, V156, P247, DOI 10.1016/j.jpeds.2009.08.010
   Kakiyama G, 2014, J LIPID RES, V55, P978, DOI 10.1194/jlr.D047506
   Keskin M, 2005, PEDIATRICS, V115, pE500, DOI 10.1542/peds.2004-1921
   Kokke FTM, 2008, J PEDIATR GASTR NUTR, V47, P592, DOI 10.1097/MPG.0b013e318162c43c
   Koleva PT, 2015, NUTRIENTS, V7, P2237, DOI 10.3390/nu7042237
   Kowalski KC, 1997, PEDIATR EXERC SCI, V9, P342, DOI 10.1123/pes.9.4.342
   Kowalski KC, 1997, PEDIATR EXERC SCI, V9, P174, DOI 10.1123/pes.9.2.174
   Lane MM, 2011, J PEDIATR-US, V159, P437, DOI 10.1016/j.jpeds.2011.03.002
   Mastrangelo A, 2016, INT J OBESITY, V40, P1494, DOI 10.1038/ijo.2016.92
   Matsuda M, 1999, DIABETES CARE, V22, P1462, DOI 10.2337/diacare.22.9.1462
   Mego M, 2017, NEUROGASTROENT MOTIL, V29, DOI 10.1111/nmo.13080
   Moin T, 2018, AM J PREV MED, V55, P565, DOI 10.1016/j.amepre.2018.04.038
   Muller M, 2018, NUTRIENTS, V10, DOI 10.3390/nu10030275
   Muniyappa R, 2008, AM J PHYSIOL-ENDOC M, V294, pE15, DOI 10.1152/ajpendo.00645.2007
   Nguyen NK, 2020, MICROBIOME, V8, DOI 10.1186/s40168-020-00887-w
   O'Keefe SJ, 2019, LANCET GASTROENTEROL, V4, P984, DOI 10.1016/S2468-1253(19)30257-2
   Oksanen J., 2022, PACKAGE VEGAN COMMUN, DOI DOI 10.4135/9781412971874.N145
   Pal S, 2017, NUTRIENTS, V9, DOI 10.3390/nu9020091
   Pastor-Villaescusa B, 2017, PEDIATRICS, V140, DOI [10.1542/peds.2017-1205, 10.1542/peds.2016-4285]
   Pedersen HK, 2016, NATURE, V535, P376, DOI 10.1038/nature18646
   Peng Y, 2020, GENES-BASEL, V11, DOI 10.3390/genes11080904
   PHILLIPS DIW, 1994, DIABETIC MED, V11, P286, DOI 10.1111/j.1464-5491.1994.tb00273.x
   Psichas A, 2015, INT J OBESITY, V39, P424, DOI 10.1038/ijo.2014.153
   Rampelli S, 2018, COMMUN BIOL, V1, DOI 10.1038/s42003-018-0221-5
   Rasmussen AR, 2015, PEDIATRICS, V135, P86, DOI 10.1542/peds.2014-0793
   Reimer RA, 2014, J ENDOCRINOL, V220, P361, DOI 10.1530/JOE-13-0484
   Reynolds A, 2019, LANCET, V393, P434, DOI 10.1016/S0140-6736(18)31809-9
   Ridaura VK, 2013, SCIENCE, V341, P1079, DOI 10.1126/science.1241214
   Russell WR, 2011, AM J CLIN NUTR, V93, P1062, DOI 10.3945/ajcn.110.002188
   Segata N, 2011, GENOME BIOL, V12, DOI 10.1186/gb-2011-12-6-r60
   Sharma AK, 2015, PEDIATR RES, V78, P723, DOI 10.1038/pr.2015.160
   Stagi S, 2017, NUTRIENTS, V9, DOI 10.3390/nu9050524
   Sun LJ, 2018, PROTEIN CELL, V9, P397, DOI 10.1007/s13238-018-0546-3
   Tramontana F, 2020, DIABETES, V69, DOI 10.2337/db20-227-OR
   Tremaroli V, 2010, GUT, V59, P1589, DOI 10.1136/gut.2010.223594
   Tun HM, 2018, JAMA PEDIATR, V172, P368, DOI 10.1001/jamapediatrics.2017.5535
   Tun MH, 2018, CAN MED ASSOC J, V190, pE1097, DOI 10.1503/cmaj.170809
   Vaccaro O, 2004, METABOLISM, V53, P1522, DOI 10.1016/j.metabol.2004.05.017
   Varni JW, 2001, MED CARE, V39, P800, DOI 10.1097/00005650-200108000-00006
   Venkataraman A, 2016, MICROBIOME, V4, DOI 10.1186/s40168-016-0178-x
   Wang Z, 2008, Int J Body Compos Res, V6, P173
   Weiss R, 2007, DIABETES CARE, V30, P1845, DOI 10.2337/dc07-0325
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Zeitler P, 2019, WORLD J PEDIATR, V15, P315, DOI 10.1007/s12519-019-00247-1
   Zhang CH, 2015, EBIOMEDICINE, V2, P968, DOI 10.1016/j.ebiom.2015.07.007
   Zhang C, 2020, PHARMACOL RES, V159, DOI 10.1016/j.phrs.2020.104985
   Zhao LP, 2018, SCIENCE, V359, P1151, DOI 10.1126/science.aao5774
   Zheng DP, 2020, CELL RES, V30, P492, DOI 10.1038/s41422-020-0332-7
   Zheng JL, 2018, J AGR FOOD CHEM, V66, P5821, DOI [10.1021/acsjafc.8b00829, 10.1021/acs.jafc.8b00829]
NR 87
TC 3
Z9 3
U1 0
U2 12
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1745-6215
J9 TRIALS
JI Trials
PD FEB 17
PY 2021
VL 22
IS 1
AR 148
DI 10.1186/s13063-021-05060-8
PG 16
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA QL4XS
UT WOS:000621082300002
PM 33596993
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Yang, L
   Yang, JX
   Liang, X
   Huang, WJ
   Zhang, XX
   Li, R
AF Yang, Lu
   Yang, Jianxin
   Liang, Xiao
   Huang, Wenjun
   Zhang, Xiaoxi
   Li, Rong
TI Uncovering antiobesity-related hypertension targets and mechanisms of
   metformin, an antidiabetic medication
SO BIOENGINEERED
LA English
DT Article
DE Metformin; obesity; hypertension; bioinformatics findings
ID MOTIF LIGAND 2; PULMONARY-HYPERTENSION; GUT MICROBIOTA; PROTEIN-KINASE;
   VITAMIN-C; OBESITY; INFLAMMATION; ACTIVATION; STRESS
AB Metformin, a common clinical drug used to treat diabetes mellitus, is found with potential antiobese actions as reported in increasing evidences. However, the detailed mechanisms of metformin-antiobesity-related hypertension remain unrevealed. We have utilized the bioinformatics strategy, including network pharmacology and molecular docking analyses, to uncover pharmacological targets and molecular pathways of bioactive compounds against clinical disorders, such as cancers, coronavirus disease 2019. In this report, the in-silico approaches using network pharmacology and molecular docking was utilized to identify the core targets, pharmacological functions and mechanisms of metformin against obesity-related hypertension. The networking analysis identified 154 differentially expressed genes of obesity and hypertension, and 21 interaction genes, 6 core genes of metformin treating obesity-related hypertension. As results, molecular docking findings indicated the binding capability of metformin with key proteins, including interleukin 6 (IL-6) and chemokine (C-C motif) Ligand 2 (CCL2) expressed in obesity- and hypertension-dependent tissues. Metformin-exerted antihypertension/obesity actions involved in metabolic regulation, inflammatory suppression. And antihypertension/obesity mechanisms of metformin were revealed, including regulation of inflammatory and immunological signaling pathways for ameliorating microenvironmental homeostasis in targeting tissues. In conclusion, our current bioinformatics findings have uncovered all pharmacological targets, biological functions and signaling pathways of metformin treating obesity-related hypertension, thus promoting its clinical application in future.
C1 [Yang, Lu; Liang, Xiao; Zhang, Xiaoxi] Guilin Med Univ, Fac Basic Med, Huan Cheng North 2nd Rd 109, Guilin 541004, Peoples R China.
   [Yang, Jianxin] Guangxi Med Univ, Cardiol Dept Area 1, Guigang City Peoples Hosp, Affiliated Hosp 8, Guigang, Guangxi, Peoples R China.
   [Huang, Wenjun; Li, Rong] Guilin Med Univ, Lab Environm Pollutants & Integrat Omics, Huan Cheng North 2nd Rd 109, Guilin 541042, Peoples R China.
C3 Guilin Medical University; Guangxi Medical University; Guilin Medical
   University
RP Zhang, XX (通讯作者)，Guilin Med Univ, Fac Basic Med, Huan Cheng North 2nd Rd 109, Guilin 541004, Peoples R China.; Li, R (通讯作者)，Guilin Med Univ, Lab Environm Pollutants & Integrat Omics, Huan Cheng North 2nd Rd 109, Guilin 541042, Peoples R China.
EM mike_527@163.com; lirong1278@163.com
RI HUANG, WENJUN/GXM-9167-2022
FU National Natural Science Foundation of China [81860155]; National
   Natural Science Foundation of Guangxi [2019GXNSFBA185015,
   2018GXNSFAA281160]
FX This work has been supported by the National Natural Science Foundation
   of China (No. 81860155) and National Natural Science Foundation of
   Guangxi (No. 2019GXNSFBA185015, 2018GXNSFAA281160).
CR Amin S, 2019, BRIT J CLIN PHARMACO, V85, P37, DOI 10.1111/bcp.13780
   Anderson AJ, 2016, J CLIN ENDOCR METAB, V101, P3787, DOI 10.1210/jc.2016-2069
   Bluher M, 2019, NAT REV ENDOCRINOL, V15, P288, DOI 10.1038/s41574-019-0176-8
   Bray GA, 2017, OBES REV, V18, P715, DOI 10.1111/obr.12551
   Chooi YC, 2019, METABOLISM, V92, P6, DOI 10.1016/j.metabol.2018.09.005
   Dean A, 2016, HYPERTENSION, V68, P446, DOI 10.1161/HYPERTENSIONAHA.116.07353
   Duan QL, 2017, BRIT J PHARMACOL, V174, P2140, DOI 10.1111/bph.13833
   Durham GA, 2019, BIOCHEM SOC T, V47, P1143, DOI 10.1042/BST20190046
   Hu LH, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0183934
   Jing YY, 2018, MOL CELL ENDOCRINOL, V461, P256, DOI 10.1016/j.mce.2017.09.025
   Lai YC, 2016, CIRCULATION, V133, P717, DOI 10.1161/CIRCULATIONAHA.115.018935
   Lee H, 2018, GUT MICROBES, V9, P155, DOI 10.1080/19490976.2017.1405209
   Li J, 2019, EUR J PHARMACOL, V858, DOI 10.1016/j.ejphar.2019.172483
   Li R, 2021, BRIEF BIOINFORM, V22, DOI 10.1093/bib/bbaa079
   Li R, 2021, BRIEF BIOINFORM, V22, P1279, DOI 10.1093/bib/bbaa300
   Li R, 2021, FREE RADICAL BIO MED, V164, P130, DOI 10.1016/j.freeradbiomed.2020.12.455
   Li R, 2021, CHEMOSPHERE, V263, DOI 10.1016/j.chemosphere.2020.128242
   Li R, 2020, AGING-US, V12, P15784, DOI 10.18632/aging.103888
   Li R, 2021, BRIEF BIOINFORM, V22, P1161, DOI 10.1093/bib/bbaa141
   Li R, 2020, FOOD FUNCT, V11, P4765, DOI [10.1039/d0fo00421a, 10.1039/D0FO00421A]
   Li R, 2020, BIOFACTORS, V46, P158, DOI 10.1002/biof.1583
   Li R, 2019, J CELL BIOCHEM, V120, P11265, DOI 10.1002/jcb.28404
   Liang YJ, 2020, EUR J PHARMACOL, V881, DOI 10.1016/j.ejphar.2020.173227
   Madrigal JLM, 2014, ADV EXP MED BIOL, V824, P209, DOI 10.1007/978-3-319-07320-0_15
   Matsumoto K, 2020, HYPERTENSION, V75, P580, DOI 10.1161/HYPERTENSIONAHA.119.13478
   Nong Y, 2020, AGING-US, V12, P19468, DOI 10.18632/aging.103886
   Oparil S, 2018, NAT REV DIS PRIMERS, V4, DOI 10.1038/nrdp.2018.14
   Pascale A, 2019, CURR OPIN PHARMACOL, V49, P1, DOI 10.1016/j.coph.2019.03.011
   Pullamsetti SS, 2018, J CLIN INVEST, V128, P1720, DOI 10.1172/JCI120415
   Qin XY, 2021, J CELL MOL MED, V25, P677, DOI 10.1111/jcmm.16117
   Samaan MC, 2013, BMC PEDIATR, V13, DOI 10.1186/1471-2431-13-47
   Seifarth C, 2013, EXP CLIN ENDOCR DIAB, V121, P27, DOI 10.1055/s-0032-1327734
   Seravalle G, 2017, PHARMACOL RES, V122, P1, DOI 10.1016/j.phrs.2017.05.013
   Smith DK, 2020, AM FAM PHYSICIAN, V101, P341
   Su M, 2019, INT IMMUNOPHARMACOL, V66, P383, DOI 10.1016/j.intimp.2018.11.048
   Tanaka T, 2014, CSH PERSPECT BIOL, V6, DOI 10.1101/cshperspect.a016295
   Timper K, 2017, CELL REP, V19, P267, DOI 10.1016/j.celrep.2017.03.043
   Ventura Hector O, 2018, Curr Opin Cardiol, V33, P375, DOI 10.1097/HCO.0000000000000534
   Wallenius K, 2003, EXPERT OPIN BIOL TH, V3, P1061, DOI 10.1517/14712598.3.7.1061
   Wang YF, 2019, LANCET GLOB HEALTH, V7, pE1166, DOI 10.1016/S2214-109X(19)30276-1
   Wenzel UO, 2017, AM J PHYSIOL-HEART C, V312, pH349, DOI 10.1152/ajpheart.00759.2016
   Wu K, 2019, J ADV RES, V20, P43, DOI 10.1016/j.jare.2019.05.003
   Zhou R, 2019, ENVIRON TOXICOL PHAR, V70, DOI 10.1016/j.etap.2019.103200
NR 43
TC 10
Z9 10
U1 1
U2 11
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 2165-5979
EI 2165-5987
J9 BIOENGINEERED
JI Bioengineered
PD JAN 1
PY 2021
VL 12
IS 1
BP 4757
EP 4767
DI 10.1080/21655979.2021.1954581
PG 11
WC Biotechnology & Applied Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology
GA TT2XY
UT WOS:000680215300001
PM 34334083
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Wanchaitanawong, W
   Thinrungroj, N
   Chattipakorn, SC
   Chattipakorn, N
   Shinlapawittayatorn, K
AF Wanchaitanawong, Wasuwit
   Thinrungroj, Nithi
   Chattipakorn, Siriporn C.
   Chattipakorn, Nipon
   Shinlapawittayatorn, Krekwit
TI Repurposing metformin as a potential treatment for inflammatory bowel
   disease: Evidence from cell to the clinic
SO INTERNATIONAL IMMUNOPHARMACOLOGY
LA English
DT Article
DE Inflammatory bowel disease; Ulcerative colitis; Crohn?s disease;
   Metformin; AMPK
ID NF-KAPPA-B; INTESTINAL BARRIER DYSFUNCTION; CROHNS-DISEASE; ANTIOXIDANT
   DEFENSES; DOSE INTENSIFICATION; OXIDATIVE STRESS; TIGHT JUNCTIONS;
   COLITIS; PERMEABILITY; REQUIREMENT
AB Inflammatory bowel disease (IBD) comprises a group of intestinal disorders, including ulcerative colitis and Crohn's disease. Currently, the incidence and prevalence of IBD are increasing globally. Although both biologic agents and small molecule drugs have been available for treatment of IBD patients, approximately one third of treated patients do not respond to these treatments. Therefore, novel therapy or repurposing of drugs have been extensively studied to obtain an effective therapy for IBD patients. Among these drugs, metformin has been reported to exert beneficial effects in many organs via its anti-inflammatory effect. Additionally, evidence from cellular to clinical models of IBD demonstrated significant positive effects of metformin on inflammatory pathways, oxidative stress, gut barrier integrity, and gut microbiota. In this review, the beneficial effects of metformin on IBD are comprehensively summarized and discussed using the results of in vitro, in vivo, and clinical studies. Increased understanding of these protective effects and the underlying mechanisms may pave the way for effective use of metformin in IBD patients.
C1 [Wanchaitanawong, Wasuwit; Thinrungroj, Nithi] Chiang Mai Univ, Fac Med, Dept Internal Med, Div Gastroenterol & Hepatol, Chiang Mai 50200, Thailand.
   [Chattipakorn, Siriporn C.; Chattipakorn, Nipon; Shinlapawittayatorn, Krekwit] Chiang Mai Univ, Fac Med, Cardiac Electrophysiol Res & Training Ctr, Chiang Mai 50200, Thailand.
   [Chattipakorn, Siriporn C.; Chattipakorn, Nipon; Shinlapawittayatorn, Krekwit] Chiang Mai Univ, Ctr Excellence Cardiac Electrophysiol Res, Chiang Mai 50200, Thailand.
   [Chattipakorn, Nipon; Shinlapawittayatorn, Krekwit] Chiang Mai Univ, Fac Med, Dept Physiol, Cardiac Electrophysiol Unit, Chiang Mai 50200, Thailand.
C3 Chiang Mai University; Chiang Mai University; Chiang Mai University;
   Chiang Mai University
RP Shinlapawittayatorn, K (通讯作者)，Chiang Mai Univ, Fac Med, Cardiac Electrophysiol Res & Training Ctr, Chiang Mai 50200, Thailand.
EM kshinlap@gmail.com
RI Thinrungroj, Nithi/HKD-8938-2023
OI Wanchaitanawong, Wasuwit/0000-0001-7221-4196
FU National Research Council of Thailand; National Science and Technology
   Development Agency Thailand; Chiang Mai University Center of Excellence
   Award
FX This work was supported by the Senior Reserach Scholar Award from the
   National Research Council of Thailand (S.C.C.) , the NSTDA Research
   Chair grant from the National Science and Technology Development Agency
   Thailand (N.C.) , and the Chiang Mai University Center of Excellence
   Award (N.C.) .
CR Al-Dwairi A, 2018, EXP THER MED, V16, P985, DOI 10.3892/etm.2018.6222
   Amer Diabet Assoc Professional Pra, 2022, DIABETES CARE, V45, pS125, DOI 10.2337/dc22-S009
   Ben-Horin S, 2014, AUTOIMMUN REV, V13, P24, DOI 10.1016/j.autrev.2013.06.002
   Billioud V, 2011, AM J GASTROENTEROL, V106, P674, DOI 10.1038/ajg.2011.60
   Brand S, 2009, GUT, V58, P1152, DOI 10.1136/gut.2008.163667
   BUFFINTON GD, 1995, FREE RADICAL BIO MED, V19, P911, DOI 10.1016/0891-5849(95)94362-H
   Carter MJ, 2004, GUT, V53, DOI 10.1136/gut.2004.043372
   Chan HCH, 2017, J GASTROENTEROL, V52, P141, DOI 10.1007/s00535-016-1283-0
   Chang JT, 2020, NEW ENGL J MED, V383, P2652, DOI 10.1056/NEJMra2002697
   Chen FL, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19113517
   Chen L, 2018, FRONT PHARMACOL, V9, DOI 10.3389/fphar.2018.00761
   Degagne E, 2014, CLIN EXP GASTROENTER, V7, P205, DOI 10.2147/CEG.S43453
   Deng J, 2018, J CELL MOL MED, V22, P546, DOI 10.1111/jcmm.13342
   Di Fusco D, 2018, CLIN SCI, V132, P1155, DOI 10.1042/CS20180167
   El-Mahdy NA, 2021, IMMUNOPHARM IMMUNOT, V43, P192, DOI 10.1080/08923973.2021.1878214
   Fan YH, 2013, PROTEIN CELL, V4, P176, DOI 10.1007/s13238-013-2084-3
   Ferrari L, 2016, WORLD J GASTRO SURG, V8, P363, DOI 10.4240/wjgs.v8.i5.363
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Gisbert JP, 2009, AM J GASTROENTEROL, V104, P760, DOI 10.1038/ajg.2008.88
   Glassner KL, 2020, J ALLERGY CLIN IMMUN, V145, P16, DOI 10.1016/j.jaci.2019.11.003
   He XC, 2004, NAT GENET, V36, P1117, DOI 10.1038/ng1430
   Hooper KM, 2017, J CROHNS COLITIS, V11, P118, DOI 10.1093/ecco-jcc/jjw127
   Huang HL, 2020, IMMUNOL REV, V295, P15, DOI 10.1111/imr.12845
   ISSENMAN RM, 1993, CLIN INVEST MED, V16, P187
   Jankowski JAZ, 1998, LAB INVEST, V78, P1155
   JENKINS RT, 1988, CLIN INVEST MED, V11, P151
   JONES SC, 1995, GUT, V36, P724, DOI 10.1136/gut.36.5.724
   Kaspar JW, 2009, FREE RADICAL BIO MED, V47, P1304, DOI 10.1016/j.freeradbiomed.2009.07.035
   Ke HR, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.726707
   Khan I, 2019, PATHOGENS, V8, DOI 10.3390/pathogens8030126
   Khare V, 2015, INFLAMM BOWEL DIS, V21, P287, DOI 10.1097/MIB.0000000000000281
   Kim J, 2014, J BIOL CHEM, V289, P23246, DOI 10.1074/jbc.M114.577908
   Kim S, 2019, CELLS-BASEL, V8, DOI 10.3390/cells8010077
   Koh SJ, 2014, J GASTROEN HEPATOL, V29, P502, DOI 10.1111/jgh.12435
   Kristofi R, 2021, J ENDOCRINOL, V251, pR11, DOI 10.1530/JOE-21-0194
   Kruidenier L, 2003, J PATHOL, V201, P28, DOI 10.1002/path.1409
   Landy J, 2016, WORLD J GASTROENTERO, V22, P3117, DOI 10.3748/wjg.v22.i11.3117
   Lee H, 2009, CANCER CELL, V15, P283, DOI 10.1016/j.ccr.2009.02.015
   Lee JM, 2018, J BIOL CHEM, V293, P13125, DOI 10.1074/jbc.RA118.002196
   Lee SY, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0135858
   LihBrody L, 1996, DIGEST DIS SCI, V41, P2078, DOI 10.1007/BF02093613
   Lin XJ, 2018, MUCOSAL IMMUNOL, V11, P1663, DOI 10.1038/s41385-018-0018-3
   Linares R, 2021, FRONT CELL DEV BIOL, V9, DOI 10.3389/fcell.2021.703310
   Liu XW, 2021, BIOTECH HISTOCHEM, V96, P146, DOI 10.1080/10520295.2020.1776896
   Liu ZY, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.640347
   Lu Y, 2018, FRONT IMMUNOL, V9, DOI 10.3389/fimmu.2018.00072
   Luckheeram RV, 2012, CLIN DEV IMMUNOL, DOI 10.1155/2012/925135
   Maloum F, 2011, AM J PHYSIOL-GASTR L, V300, pG1065, DOI 10.1152/ajpgi.00176.2010
   Maynard CL, 2009, IMMUNITY, V31, P389, DOI 10.1016/j.immuni.2009.08.012
   McDaniel DK, 2016, INFLAMM BOWEL DIS, V22, P2265, DOI 10.1097/MIB.0000000000000858
   McGuckin MA, 2009, INFLAMM BOWEL DIS, V15, P100, DOI 10.1002/ibd.20539
   Morgan MJ, 2011, CELL RES, V21, P103, DOI 10.1038/cr.2010.178
   Neurath MF, 2014, NAT REV IMMUNOL, V14, P329, DOI 10.1038/nri3661
   Ng SC, 2017, LANCET, V390, P2769, DOI 10.1016/S0140-6736(17)32448-0
   Nishida A, 2018, CLIN J GASTROENTEROL, V11, P1, DOI 10.1007/s12328-017-0813-5
   Novak EA, 2015, FRONT CELL DEV BIOL, V3, DOI 10.3389/fcell.2015.00062
   Okumura R, 2017, EXP MOL MED, V49, DOI 10.1038/emm.2017.20
   Olivier S, 2022, CELLS-BASEL, V11, DOI 10.3390/cells11040590
   Pandey A, 2017, BIOMED PHARMACOTHER, V94, P1121, DOI 10.1016/j.biopha.2017.08.020
   Postler TS, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-97441-x
   Raine T, 2022, J CROHNS COLITIS, V16, P2, DOI 10.1093/ecco-jcc/jjab178
   Ramos GP, 2019, MAYO CLIN PROC, V94, P155, DOI 10.1016/j.mayocp.2018.09.013
   Rogler G, 1998, GASTROENTEROLOGY, V115, P357, DOI 10.1016/S0016-5085(98)70202-1
   Saber S, 2021, INFLAMMOPHARMACOLOGY, V29, P237, DOI 10.1007/s10787-020-00730-6
   Samman FS, 2018, PHARMACOL REP, V70, P488, DOI 10.1016/j.pharep.2017.11.015
   Schmitz H, 1999, GASTROENTEROLOGY, V116, P301, DOI 10.1016/S0016-5085(99)70126-5
   Schulze-Osthoff K, 1997, IMMUNOBIOLOGY, V198, P35, DOI 10.1016/S0171-2985(97)80025-3
   Sedda S, 2015, INFLAMM BOWEL DIS, V21, P2921, DOI 10.1097/MIB.0000000000000542
   Szanto I, 2005, J PATHOL, V207, P164, DOI 10.1002/path.1824
   Takahara M, 2022, FASEB J, V36, DOI 10.1096/fj.202100831RR
   Terciolo C, 2017, J CROHNS COLITIS, V11, P999, DOI 10.1093/ecco-jcc/jjx030
   Tian T, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/4535194
   Torres J, 2020, J CROHNS COLITIS, V14, P4, DOI 10.1093/ecco-jcc/jjz180
   Tseng CH, 2021, J CROHNS COLITIS, V15, P64, DOI 10.1093/ecco-jcc/jjaa136
   Tsunada S, 2003, SCAND J GASTROENTERO, V38, P1002, DOI 10.1080/00365520310005055
   Vainer B, 2000, CLIN EXP IMMUNOL, V121, P242, DOI 10.1046/j.1365-2249.2000.01296.x
   Waetzig GH, 2002, J IMMUNOL, V168, P5342, DOI 10.4049/jimmunol.168.10.5342
   Wang SQ, 2019, CANCER BIOL THER, V20, P338, DOI 10.1080/15384047.2018.1529108
   Welcker K, 2004, EUR J MED RES, V9, P456
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Wu WC, 2018, MOL PHARMACEUT, V15, P3272, DOI 10.1021/acs.molpharmaceut.8b00332
   Xiong WF, 2021, CELL DEATH DIS, V12, DOI 10.1038/s41419-021-04235-0
   Xue YS, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0168670
   Yang Q, 2001, SCIENCE, V294, P2155, DOI 10.1126/science.1065718
   Yang S, 2021, FRONT IMMUNOL, V12, DOI 10.3389/fimmu.2021.652709
   Youssef ME, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.719984
   Zeissig S, 2007, GUT, V56, P61, DOI 10.1136/gut.2006.094375
   Zhang Q, 2020, DIABET METAB SYND OB, V13, P5003, DOI 10.2147/DMSO.S286430
NR 88
TC 1
Z9 1
U1 7
U2 7
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1567-5769
EI 1878-1705
J9 INT IMMUNOPHARMACOL
JI Int. Immunopharmacol.
PD NOV
PY 2022
VL 112
AR 109230
DI 10.1016/j.intimp.2022.109230
EA SEP 2022
PG 17
WC Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Pharmacology & Pharmacy
GA 5C0UH
UT WOS:000863982700007
PM 36099786
DA 2023-06-08
ER

PT J
AU Maniar, K
   Singh, V
   Moideen, A
   Bhattacharyya, R
   Chakrabarti, A
   Banerjee, D
AF Maniar, Kunal
   Singh, Vandana
   Moideen, Amal
   Bhattacharyya, Rajasri
   Chakrabarti, Amitava
   Banerjee, Dibyajyoti
TI Inhalational supplementation of metformin butyrate: A strategy for
   prevention and cure of various pulmonary disorders
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Review
DE Metformin; Fibrosis; Inflammation; Stem cell; Cancer; Drug delivery
ID CELL LUNG-CANCER; ACTIVATED PROTEIN-KINASE; ENDOPLASMIC-RETICULUM
   STRESS; ANTIDIABETIC DRUG METFORMIN; PROGRESSION-FREE SURVIVAL; CHAIN
   FATTY-ACIDS; SODIUM-BUTYRATE; IN-VIVO; NLRP3 INFLAMMASOME;
   ENDOTHELIAL-CELLS
AB The management of chronic lung diseases such as cancer, asthma, COPD and pulmonary hypertension remains unsatisfactory till date, and several strategies are being tried to control the same. Metformin, a popular antidiabetic drug has shown promising effects in pre-clinical studies and has been subject to several trials in patients with debilitating pulmonary diseases. However, the clinical evidence for the use of metformin in these conditions is disappointing. Recent observations suggest that metformin use in diabetic patients is associated with an increase in butyrate-producing bacteria in the gut microbiome. Butyrate, similar to metformin, shows beneficial effects in pathological conditions found in pulmonary diseases. Further, the pharmacokinetic data of metformin suggests that metformin is predominantly concentrated in the gut, even after absorption. Butyrate, on the other hand, has a short half-life and thus oral supplementation of butyrate and metformin is unlikely to result in high concentrations of these drugs in the lung. In this paper, we review the pre-clinical studies of metformin and butyrate pertaining to pathologies commonly encountered in chronic lung diseases and underscore the need to administer these drugs directly to the lung via the inhalational route.
C1 [Maniar, Kunal; Moideen, Amal; Chakrabarti, Amitava; Banerjee, Dibyajyoti] Postgrad Inst Med Educ & Res, Dept Pharmacol, Chandigarh, India.
   [Singh, Vandana; Bhattacharyya, Rajasri] Postgrad Inst Med Educ & Res, Dept Expt Med & Biotechnol, Chandigarh, India.
C3 Post Graduate Institute of Medical Education & Research (PGIMER),
   Chandigarh; Post Graduate Institute of Medical Education & Research
   (PGIMER), Chandigarh
RP Banerjee, D (通讯作者)，PGIMER, Dept Expt Med & Biotechnol, Res Block B,Sect 12, Chandigarh, India.
EM dibyajyoti5200@yahoo.co.in
RI Singh, Vandana/IQV-5543-2023
CR Adcock IM, 2003, J ENDOCRINOL, V178, P347, DOI 10.1677/joe.0.1780347
   Agard C, 2009, BRIT J PHARMACOL, V158, P1285, DOI 10.1111/j.1476-5381.2009.00445.x
   Ahmed I, 2015, J THORAC DIS, V7, P346, DOI 10.3978/j.issn.2072-1439.2014.12.32
   Ahn MJ, 2017, BIOTECHNOL APPL BIOC, V64, P836, DOI 10.1002/bab.1584
   An D, 2006, DIABETOLOGIA, V49, P2174, DOI 10.1007/s00125-006-0338-9
   [Anonymous], 2014, PHARM COMPOSITION KI
   Arrieta O, 2016, BMC CANCER, V16, DOI 10.1186/s12885-016-2658-6
   Athanazio R, 2012, CLINICS, V67, P1335, DOI 10.6061/clinics/2012(11)19
   Baarsma HA, 2017, THORAX, V72, P746, DOI 10.1136/thoraxjnl-2016-209753
   Baarsma HA, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0025450
   Bae CH, 2011, BIOCHEM BIOPH RES CO, V409, P669, DOI 10.1016/j.bbrc.2011.05.062
   Baker EH, 2006, THORAX, V61, P284, DOI 10.1136/thx.2005.051029
   Barnes PJ, 2010, RESPIRATION, V80, P89, DOI 10.1159/000315416
   Ben Sahra I, 2011, CANCER RES, V71, P4366, DOI 10.1158/0008-5472.CAN-10-1769
   Bouchard A, 2008, EUR J PHARM BIOPHARM, V70, P389, DOI 10.1016/j.ejpb.2008.03.020
   Buse JB, 2016, DIABETES CARE, V39, P198, DOI 10.2337/dc15-0488
   Busillo JM, 2011, J BIOL CHEM, V286, P38703, DOI 10.1074/jbc.M111.275370
   Cabreiro F, 2013, CELL, V153, P228, DOI 10.1016/j.cell.2013.02.035
   Cameron AR, 2016, CIRC RES, V119, P652, DOI 10.1161/CIRCRESAHA.116.308445
   Canani RB, 2011, WORLD J GASTROENTERO, V17, P1519, DOI [10.3748/wjg.v17.i12. 1519, 10.3748/wjg.v17.i12.1519]
   Cavailles A, 2013, EUR RESPIR REV, V22, P454, DOI 10.1183/09059180.00008612
   Chen TH, 2007, BIOCHEM BIOPH RES CO, V355, P913, DOI 10.1016/j.bbrc.2007.02.057
   Chen XQ, 2017, BIOCHEM PHARMACOL, V142, P111, DOI 10.1016/j.bcp.2017.06.136
   Cho JA, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0110086
   Claus S, 2014, EUR J PHARM BIOPHARM, V86, P1, DOI 10.1016/j.ejpb.2013.11.005
   Colvin Kelley L, 2014, J Pulm Respir Med, V4
   Cufi S, 2010, CELL CYCLE, V9, P4461, DOI 10.4161/cc.9.22.14048
   Cultrone A, 2013, EUR J IMMUNOL, V43, P1053, DOI 10.1002/eji.201142340
   CUMMINGS JH, 1987, GUT, V28, P1221, DOI 10.1136/gut.28.10.1221
   Davis BJ, 2006, DIABETES, V55, P496, DOI 10.2337/diabetes.55.02.06.db05-1064
   Dazzi F, 2011, BEST PRACT RES CL HA, V24, P49, DOI 10.1016/j.beha.2011.01.002
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Dean A., 1979, HYPERTENSION, V2016, P446, DOI [10.1161/HYPERTENSIONAHA.116, DOI 10.1161/HYPERTENSIONAHA.116]
   den Besten G, 2015, DIABETES, V64, P2398, DOI 10.2337/db14-1213
   Denlinger CE, 2004, J THORAC CARDIOV SUR, V127, P1078, DOI 10.1016/S0022-5223(03)01321-7
   Dhillon Samjot Singh, 2014, J Cancer Sci Ther, V6, P217
   Dickson RP, 2016, ANNU REV PHYSIOL, V78, P481, DOI 10.1146/annurev-physiol-021115-105238
   Edwards DA, 1997, SCIENCE, V276, P1868, DOI 10.1126/science.276.5320.1868
   Eickelberg O, 1999, J BIOL CHEM, V274, P1005, DOI 10.1074/jbc.274.2.1005
   Evans JMM, 2005, BMJ-BRIT MED J, V330, P1304, DOI 10.1136/bmj.38415.708634.F7
   Faner Rosa, 2016, ERJ Open Res, V2
   FINNIE IA, 1995, GUT, V36, P93, DOI 10.1136/gut.36.1.93
   Fontana F, 2000, AM J MED, V109, P621, DOI 10.1016/S0002-9343(00)00608-2
   Foronjy Robert F, 2012, Cells, V1, P874
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Frank MG, 2010, BRAIN BEHAV IMMUN, V24, P19, DOI 10.1016/j.bbi.2009.07.008
   GALUSKA D, 1994, DIABETOLOGIA, V37, P826, DOI 10.1007/BF00404340
   Garnett JP, 2013, THORAX, V68, P835, DOI 10.1136/thoraxjnl-2012-203178
   Gaudier E, 2004, AM J PHYSIOL-GASTR L, V287, pG1168, DOI 10.1152/ajpgi.00219.2004
   Geller, 2009, RESP CARE, V54, P767
   Germeyer A, 2011, REPROD BIOMED ONLINE, V22, P327, DOI 10.1016/j.rbmo.2010.11.006
   Ghaedi M, 2013, J CLIN INVEST, V123, P4950, DOI 10.1172/JCI68793
   GLICK AB, 1989, CELL REGUL, V1, P87, DOI 10.1091/mbc.1.1.87
   GROSSMAN J, 1994, J ASTHMA, V31, P55, DOI 10.3109/02770909409056770
   Hakami NY, 2016, J CELL MOL MED, V20, P1932, DOI 10.1111/jcmm.12885
   Han G, 2014, INVEST OPHTH VIS SCI, V55, P5616, DOI 10.1167/iovs.14-14371
   Han MK, 2014, LANCET RESP MED, V2, P548, DOI 10.1016/S2213-2600(14)70069-4
   Healy AM, 2014, ADV DRUG DELIVER REV, V75, P32, DOI 10.1016/j.addr.2014.04.005
   Hermoso MA, 2004, MOL CELL BIOL, V24, P4743, DOI 10.1128/MCB.24.11.4743-4756.2004
   Hitchings A. W., 2015, COPD, pA3965, DOI [10.1164/ajrccm-conference.2015.191.1_MeetingAbstracts.A3965, DOI 10.1164/AJRCCM-CONFERENCE.2015.191.1_MEETINGABSTRACTS.A3965]
   Hitchings A. W., 2015, C22 FEEL FINE NEW TR, pA3966, DOI [10.1164/ajrccm-conference.2015.191.1_MeetingAbstracts.A3966, DOI 10.1164/AJRCCM-CONFERENCE.2015.191.1_MEETINGABSTRACTS.A3966]
   Hitchings AW, 2016, THORAX, V71, P587, DOI 10.1136/thoraxjnl-2015-208035
   Hitchings AW, 2015, COPD, V12, P126, DOI [10.3109/15412555.2014.898052, 10.3109/15412555.2015.898052]
   Holland WL, 2007, CELL METAB, V5, P167, DOI 10.1016/j.cmet.2007.01.002
   Hollins F, 2016, RESP RES, V17, DOI 10.1186/s12931-016-0403-y
   Hoppentocht M, 2014, ADV DRUG DELIVER REV, V75, P18, DOI 10.1016/j.addr.2014.04.004
   HUNDAL HS, 1992, ENDOCRINOLOGY, V131, P1165, DOI 10.1210/en.131.3.1165
   Ito K, 2012, INT J CHRONIC OBSTR, V7, P641, DOI 10.2147/COPD.S28250
   IZUMI T, 1995, BIOCHEM J, V305, P829, DOI 10.1042/bj3050829
   Jadhav KS, 2013, MECH AGEING DEV, V134, P548, DOI 10.1016/j.mad.2013.11.002
   Jatakanon A, 1999, AM J RESP CRIT CARE, V160, P1532, DOI 10.1164/ajrccm.160.5.9806170
   Kajbaf F, 2016, CLIN PHARMACOKINET, V55, P439, DOI 10.1007/s40262-015-0323-x
   Kang KY, 2013, INT IMMUNOPHARMACOL, V16, P85, DOI 10.1016/j.intimp.2013.03.020
   Kesimer M, 2017, NEW ENGL J MED, V377, P911, DOI 10.1056/NEJMoa1701632
   Kesser KC, 2009, RESP CARE, V54, P754, DOI 10.4187/002013209790983250
   Kim S. W., 2012, Butyric acid salt of n, n-dimethyl imidocarbon imidic diamide, method of preparing same, and pharmaceutical compositions and combinations containing same, Patent No. [US20120135952 A1, 20120135952US]
   Kim S, 2016, J THORAC CARDIOV SUR, V152, P62, DOI 10.1016/j.jtcvs.2016.03.072
   KOSHIHARA Y, 1981, BIOCHIM BIOPHYS ACTA, V664, P278
   Kratschmar DV, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0036774
   Kumar N, 2002, BRIT J PHARMACOL, V137, P329, DOI 10.1038/sj.bjp.0704878
   Kume H., 2014, MOL SIGNALS CELL MEC, pA5589, DOI [10.1164/ajrccm-conference.2014.189.1_MeetingAbstracts.A5589, DOI 10.1164/AJRCCM-CONFERENCE.2014.189.1_MEETINGABSTRACTS.A5589]
   Lau EMT, 2017, NAT REV CARDIOL, V14, DOI 10.1038/nrcardio.2017.84
   Lazarova Darina L, 2014, BMC Res Notes, V7, P226, DOI 10.1186/1756-0500-7-226
   Leclerc GM, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0074420
   Lee JY, 2013, EUR J CANCER, V49, P2411, DOI 10.1016/j.ejca.2013.02.025
   Lee KM, 2016, ONCOTARGET, V7, P38500, DOI 10.18632/oncotarget.9522
   Li AY, 2016, MOL CELL ENDOCRINOL, V434, P36, DOI 10.1016/j.mce.2016.06.008
   Li C, 2017, ONCOL LETT, V13, P2873, DOI 10.3892/ol.2017.5862
   Li CY, 2016, RESPIROLOGY, V21, P1210, DOI 10.1111/resp.12818
   Lin J, 2017, INT J CANCER, V141, P254, DOI 10.1002/ijc.30724
   Lin ZH, 2008, J BIOL CHEM, V283, P33053, DOI 10.1074/jbc.M804039200
   Lipson DA, 2018, NEW ENGL J MED, V378, P1671, DOI 10.1056/NEJMoa1713901
   Liu JX, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0116183
   Liu SH, 2016, ONCOTARGET, V7, P22116, DOI 10.18632/oncotarget.7904
   Mak JCW, 2002, BRIT J PHARMACOL, V135, P987, DOI 10.1038/sj.bjp.0704545
   Mallia P, 2018, J ALLERGY CLIN IMMUN, V142, P815, DOI 10.1016/j.jaci.2017.10.017
   Mamtani R, 2014, DIABETES CARE, V37, P1910, DOI 10.2337/dc13-1489
   Maniar K, 2017, MED HYPOTHESES, V108, P51, DOI 10.1016/j.mehy.2017.08.002
   Maniar K, 2017, PHARMACOL RES, V117, P103, DOI 10.1016/j.phrs.2016.12.003
   Matsumoto N, 2006, KIDNEY INT, V69, P257, DOI 10.1038/sj.ki.5000028
   McCreight LJ, 2016, DIABETOLOGIA, V59, P426, DOI 10.1007/s00125-015-3844-9
   Medairos RA, 2016, J THORAC CARDIOV SUR, V152, P55, DOI 10.1016/j.jtcvs.2016.03.094
   Molyneaux PL, 2014, AM J RESP CRIT CARE, V190, P906, DOI 10.1164/rccm.201403-0541OC
   Morgillo F, 2017, ESMO OPEN, V2, DOI 10.1136/esmoopen-2016-000132
   Morikawa A, 2004, J ENDOTOXIN RES, V10, P33, DOI 10.1177/09680519040100010401
   Mosen K, 2004, PHARM DEV TECHNOL, V9, P409, DOI 10.1081/PDT-200035795
   Na HJ, 2015, MECH AGEING DEV, V149, P8, DOI 10.1016/j.mad.2015.05.004
   Napolitano A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100778
   NOVOGRODSKY A, 1983, CANCER-AM CANCER SOC, V51, P9, DOI 10.1002/1097-0142(19830101)51:1<9::AID-CNCR2820510104>3.0.CO;2-4
   Odievre MH, 2007, AM J HEMATOL, V82, P357, DOI 10.1002/ajh.20709
   Oldham JM, 2017, FRONT MED-LAUSANNE, V4, DOI 10.3389/fmed.2017.00123
   Pant K, 2017, CHEM-BIOL INTERACT, V273, P99, DOI 10.1016/j.cbi.2017.06.001
   Papi A, 2018, LANCET, V391, P783, DOI 10.1016/S0140-6736(17)33311-1
   Parikh AB, 2017, INVEST NEW DRUG, V35, P813, DOI 10.1007/s10637-017-0511-7
   Park MJ, 2016, J NEUROINFLAMM, V13, DOI 10.1186/s12974-016-0765-6
   Pellizzaro C, 2001, INT J CANCER, V91, P654, DOI 10.1002/1097-0215(200002)9999:9999<::AID-IJC1117>3.0.CO;2-I
   Peters-Golden M, 2006, EUR RESPIR J, V27, P495, DOI 10.1183/09031936.06.00077205
   Petrache I, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0062968
   Peuler JD, 1999, CARDIOVASC RES, V43, P237, DOI 10.1016/S0008-6363(99)00051-6
   Prasad S, 2017, ANAL BIOCHEM, V534, P86, DOI 10.1016/j.ab.2017.07.018
   Pryor PR, 2000, BIOCHEM J, V348, P83, DOI 10.1042/0264-6021:3480083
   Quentin T, 2012, DIS MODEL MECH, V5, P259, DOI 10.1242/dmm.008110
   Rabinovitch M, 2012, J CLIN INVEST, V122, P4306, DOI 10.1172/JCI60658
   Renzoni Elisabetta, 2014, F1000Prime Rep, V6, P69, DOI 10.12703/P6-69
   Ridge CA, 2013, SEMIN INTERVENT RAD, V30, P93, DOI 10.1055/s-0033-1342949
   Rishikof DC, 2004, J CELL BIOCHEM, V91, P740, DOI 10.1002/jcb.10742
   Rubin BK, 2014, ADV DRUG DELIVER REV, V75, P141, DOI 10.1016/j.addr.2014.06.008
   Rubin BK, 2011, RESP CARE, V56, P1411, DOI 10.4187/respcare.01246
   Saha M, 2018, CANCER RES, V78, P1497, DOI 10.1158/0008-5472.CAN-17-2090
   Salem S, 2012, BRIT J PHARMACOL, V166, P2036, DOI 10.1111/j.1476-5381.2012.01885.x
   Samavedam U. K. S., 2016, J IMMUNOL, V196
   Sanders Mark, 2007, Prim Care Respir J, V16, P71, DOI 10.3132/pcrj.2007.00017
   Sato N, 2016, RESP RES, V17, DOI 10.1186/s12931-016-0420-x
   SCHEPPACH W, 1992, GASTROENTEROLOGY, V103, P51, DOI 10.1016/0016-5085(92)91094-K
   Segain JP, 2000, GUT, V47, P397, DOI 10.1136/gut.47.3.397
   Sekiya T, 2004, BIOCHEM BIOPH RES CO, V320, P680, DOI 10.1016/j.bbrc.2004.06.017
   Sekiya T, 2004, J BIOL CHEM, V279, P6840, DOI 10.1074/jbc.M310876200
   Shi J, 2017, MEDIAT INFLAMM, V2017, DOI 10.1155/2017/3520581
   Shin JM, 2016, TUMOR BIOL, V37, P14577, DOI 10.1007/s13277-016-5306-5
   Simon-Szabo L, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0097868
   Simpson JL, 2014, EUR RESPIR J, V43, P1067, DOI 10.1183/09031936.00105013
   Skoglund J, 2016, QUANTIFICATION SHORT
   Skronska-Wasek W, 2017, AM J RESP CRIT CARE, V196, P172, DOI 10.1164/rccm.201605-0904OC
   Smiechowski BB, 2013, DIABETES CARE, V36, P124, DOI 10.2337/dc12-0740
   Soberanes S., 2017, AIR POLLUT EPIDEMIOL, pA6846, DOI [10.1164/ajrccm-conference.2017.195.1_MeetingAbstracts.A6846, DOI 10.1164/AJRCCM-CONFERENCE.2017.195.1_MEETINGABSTRACTS.A6846]
   Spagnolo P, 2015, ANN MED, V47, P15, DOI 10.3109/07853890.2014.982165
   Subramaniam N, 2012, CANCER PREV RES, V5, P553, DOI 10.1158/1940-6207.CAPR-12-0053
   Suissa Samy, 2012, Rambam Maimonides Med J, V3, pe0014, DOI 10.5041/RMMJ.10082
   Suissa S, 2012, DIABETES CARE, V35, P2665, DOI 10.2337/dc12-0788
   Takatani T, 2011, MOL CELL ENDOCRINOL, V339, P114, DOI 10.1016/j.mce.2011.04.003
   Tay TR, 2016, RESPIROLOGY, V21, P1384, DOI 10.1111/resp.12838
   Terai K, 2005, MOL CELL BIOL, V25, P9554, DOI 10.1128/MCB.25.21.9554-9575.2005
   Torii K, 2017, AN BRAS DERMATOL, V92, P183, DOI 10.1590/abd1806-4841.20176198
   Tsakiridis T, 2016, J THORAC ONCOL, V11, pS50
   Tsay J. J., 2017, LUNG CANC LUNG MICRO, pA1001, DOI [10.1164/ajrccm-conference.2017.195.1_MeetingAbstracts.A1001, DOI 10.1164/AJRCCM-CONFERENCE.2017.195.1_MEETINGABSTRACTS.A1001]
   Tseng CN, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0098904
   Vazquez-Martin A, 2012, SCI REP-UK, V2, DOI 10.1038/srep00964
   Wan WYH, 2016, CHEST, V149, P1445, DOI 10.1016/j.chest.2016.01.024
   Wang XK, 2015, SCI REP-UK, V5, DOI 10.1038/srep12676
   Watson A. M., 2014, NOV PATHW PULM FIBRO, pA6290, DOI [10.1164/ajrccm-conference.2014.189.1_MeetingAbstracts.A6290, DOI 10.1164/AJRCCM-CONFERENCE.2014.189.1_MEETINGABSTRACTS.A6290]
   Wetzel M, 2014, CANCER METAB, V2, DOI 10.1186/2049-3002-2-S1-P84
   Wickert L, 2004, J HEPATOL, V40, P69, DOI 10.1016/j.jhep.2003.09.026
   WILCOCK C, 1994, XENOBIOTICA, V24, P49, DOI 10.3109/00498259409043220
   Winder AA, 2009, RESP RES, V10, DOI 10.1186/1465-9921-10-96
   Wink KCJ, 2016, RADIOTHER ONCOL, V118, P453, DOI 10.1016/j.radonc.2016.01.012
   Wolters PJ, 2014, ANNU REV PATHOL-MECH, V9, P157, DOI 10.1146/annurev-pathol-012513-104706
   Wright TK, 2016, RESPIROLOGY, V21, P467, DOI 10.1111/resp.12730
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Wu N, 2011, NEOPLASMA, V58, P482, DOI 10.4149/neo_2011_06_482
   Wu YY, 2014, EXP LUNG RES, V40, P251, DOI 10.3109/01902148.2014.913092
   WURTMAN RJ, 1966, J BIOL CHEM, V241, P2301
   Xiao HJ, 2016, SCI REP-UK, V6, DOI 10.1038/srep33309
   Xing XG, 2016, J PHYSIOL BIOCHEM, V73, P405, DOI 10.1007/s13105-017-0568-y
   Yamane M, 2007, ARCH BIOCHEM BIOPHYS, V459, P159, DOI 10.1016/j.abb.2007.01.008
   Yang H, 2014, MOL PHARMACOL, V85, P249, DOI 10.1124/mol.113.089763
   Yang IV, 2015, TRANSL RES, V165, P48, DOI 10.1016/j.trsl.2014.03.011
   Yasukawa A, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0064281
   Yayan J, 2016, ADV EXP MED BIOL, V910, P31, DOI 10.1007/5584_2015_206
   Young MJ, 2010, ENDOCRINOLOGY, V151, P2622, DOI 10.1210/en.2009-1476
   Yousef M, 2017, CANCERS, V9, DOI 10.3390/cancers9050045
   Zamora R, 2017, J TRAUMA ACUTE CARE, V83, pS50, DOI 10.1097/TA.0000000000001489
   Zhou Q, 2014, ADV DRUG DELIVER REV, V75, P3, DOI 10.1016/j.addr.2014.03.006
   Zou MH, 2004, J BIOL CHEM, V279, P43940, DOI 10.1074/jbc.M404421200
NR 183
TC 11
Z9 12
U1 1
U2 15
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD NOV
PY 2018
VL 107
BP 495
EP 506
DI 10.1016/j.biopha.2018.08.021
PG 12
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA GU1PC
UT WOS:000445036200053
PM 30114633
DA 2023-06-08
ER

PT J
AU Yu, XB
   Fu, XJ
   Wu, XY
   Tang, WW
   Xu, L
   Hu, LB
   Xu, CR
   Zhou, H
   Zhou, GY
   Li, JR
   Cao, SL
   Liu, J
   Yan, F
   Wang, L
   Liu, FY
   Chen, G
AF Yu, Xiaobo
   Fu, Xiongjie
   Wu, Xinyan
   Tang, Wenwen
   Xu, Lei
   Hu, Libin
   Xu, Chaoran
   Zhou, Hang
   Zhou, Guoyang
   Li, Jianru
   Cao, Shenglong
   Liu, Jiang
   Yan, Feng
   Wang, Lin
   Liu, Fuyi
   Chen, Gao
TI Metformin Alleviates Neuroinflammation Following Intracerebral
   Hemorrhage in Mice by Regulating Microglia/Macrophage Phenotype in a Gut
   Microbiota-Dependent Manner
SO FRONTIERS IN CELLULAR NEUROSCIENCE
LA English
DT Article
DE intracerebral hemorrhage; metformin; neuroinflammation; gut microbiota;
   microglia; macrophage
ID BRAIN-INJURY; NEUROGENESIS; INHIBITION; MICROGLIA; RECOVERY; MEMORY
AB The gut microbiota plays a key role in regulating intracerebral hemorrhage (ICH)-induced neuroinflammation. The anti-neuroinflammatory effects of metformin (Met) have been reported in many central nervous system (CNS) diseases. However, whether Met regulates neuroinflammation through the gut microbiota in ICH-induced brain injury remains unknown. We found that Met treatment substantially alleviated neurological dysfunction and reduced neuroinflammation by inhibiting pro-inflammatory polarization of microglia/macrophages in mice with ICH. Moreover, Met treatment altered the microbiota composition and improved intestinal barrier function. The expression of lipopolysaccharide-binding protein (LBP), a biomarker of intestinal barrier damage, was also significantly reduced by Met treatment. Neuroinflammation was also potently ameliorated after the transplantation of fecal microbiota from Met-treated ICH mice. The neuroprotective effects of fecal microbiota transplantation (FMT) were similar to those of oral Met treatment. However, suppression of the gut microbiota negated the neuroprotective effects of Met in ICH mice. Therefore, Met is a promising therapeutic agent for neuroinflammation owing to ICH-induced imbalance of the gut microbiota.
C1 [Yu, Xiaobo; Fu, Xiongjie; Wu, Xinyan; Hu, Libin; Xu, Chaoran; Zhou, Hang; Zhou, Guoyang; Li, Jianru; Cao, Shenglong; Yan, Feng; Wang, Lin; Liu, Fuyi; Chen, Gao] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Neurosurg, Hangzhou, Peoples R China.
   [Tang, Wenwen; Xu, Lei] Zhejiang Univ, Sch Med, Hangzhou, Peoples R China.
   [Liu, Jiang] China Japan Friendship Hosp, Dept Neurosurg, Beijing, Peoples R China.
C3 Zhejiang University; Zhejiang University; China-Japan Friendship
   Hospital
RP Liu, FY; Chen, G (通讯作者)，Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Neurosurg, Hangzhou, Peoples R China.
EM liufuyi@zju.edu.cn; d-chengao@zju.edu.cn
RI Wang, Xinhua/ISR-8520-2023; Tang, Wenwen/J-2011-2012
CR Agirman G, 2021, CELL, V184, P2524, DOI 10.1016/j.cell.2021.03.022
   Ahmadi S, 2020, J GERONTOL A-BIOL, V75, pE9, DOI 10.1093/gerona/glaa056
   Bai Q, 2020, BRAIN, V143, P1297, DOI 10.1093/brain/awz393
   Benakis C, 2020, STROKE, V51, P1844, DOI 10.1161/STROKEAHA.120.029262
   Benakis C, 2016, NAT MED, V22, P516, DOI 10.1038/nm.4068
   Celorrio M, 2021, ACTA NEUROPATHOL COM, V9, DOI 10.1186/s40478-021-01137-2
   Chang CF, 2020, STROKE, V51, P612, DOI 10.1161/STROKEAHA.119.027037
   Chang CF, 2018, J CLIN INVEST, V128, P607, DOI 10.1172/JCI95612
   Chang CY, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10040623
   Chen WX, 2020, PHARMACOL RES, V161, DOI 10.1016/j.phrs.2020.105122
   Cheng YJ, 2018, INT J MOL MED, V42, P2120, DOI 10.3892/ijmm.2018.3755
   Clarke G, 2021, BRAIN BEHAV IMMUN, V95, P25, DOI 10.1016/j.bbi.2021.04.012
   Duan XC, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/1203285
   Fu XJ, 2021, J NEUROINFLAMM, V18, DOI 10.1186/s12974-021-02239-3
   Fu XJ, 2021, FRONT NEUROL, V12, DOI 10.3389/fneur.2021.562090
   Fu XJ, 2021, TRANSL STROKE RES, V12, P1018, DOI 10.1007/s12975-021-00889-2
   He L, 2015, CELL METAB, V21, P159, DOI 10.1016/j.cmet.2015.01.003
   Hill JL, 2016, J NEUROCHEM, V139, P106, DOI 10.1111/jnc.13726
   Hou YF, 2021, MICROBIOME, V9, DOI 10.1186/s40168-020-00988-6
   Jing YL, 2021, MICROBIOME, V9, DOI 10.1186/s40168-021-01007-y
   Kigerl KA, 2016, J EXP MED, V213, P2603, DOI 10.1084/jem.20151345
   Kim MS, 2020, GUT, V69, P283, DOI 10.1136/gutjnl-2018-317431
   Lan X, 2017, NAT REV NEUROL, V13, P420, DOI 10.1038/nrneurol.2017.69
   Lee J, 2020, CIRC RES, V127, P453, DOI 10.1161/CIRCRESAHA.119.316448
   Li MX, 2020, TRANSL RES, V217, P61, DOI 10.1016/j.trsl.2019.12.006
   Li Q, 2017, JCI INSIGHT, V2, DOI 10.1172/jci.insight.90777
   Li ZG, 2020, J EXP MED, V217, DOI 10.1084/jem.20200213
   Liu YQ, 2014, J NEUROINFLAMM, V11, DOI 10.1186/s12974-014-0177-4
   Lu Q, 2021, STROKE, V52, P2162, DOI 10.1161/STROKEAHA.120.032736
   Ma XY, 2021, BRAIN BEHAV IMMUN, V95, P68, DOI 10.1016/j.bbi.2021.02.011
   Mendelow AD, 2013, LANCET, V382, P397, DOI 10.1016/S0140-6736(13)60986-1
   Mor DE, 2020, P NATL ACAD SCI USA, V117, P26438, DOI 10.1073/pnas.2009838117
   Mueller NT, 2021, DIABETES CARE, V44, P1462, DOI 10.2337/dc20-2257
   Olsen AB, 2013, NEUROGASTROENT MOTIL, V25, DOI 10.1111/nmo.12121
   Ou ZR, 2018, BRAIN BEHAV IMMUN, V69, P351, DOI 10.1016/j.bbi.2017.12.009
   Qi BX, 2017, NEUROCHEM RES, V42, P2912, DOI 10.1007/s11064-017-2322-9
   Ryu YK, 2020, NEUROPHARMACOLOGY, V175, DOI 10.1016/j.neuropharm.2020.108173
   Sadler R, 2020, J NEUROSCI, V40, P1162, DOI 10.1523/JNEUROSCI.1359-19.2019
   Shi SX, 2021, SCI TRANSL MED, V13, DOI 10.1126/scitranslmed.abc7029
   Singh V, 2016, J NEUROSCI, V36, P7428, DOI 10.1523/JNEUROSCI.1114-16.2016
   Spychala MS, 2018, ANN NEUROL, V84, P23, DOI 10.1002/ana.25250
   Taylor RA, 2017, J CLIN INVEST, V127, P280, DOI 10.1172/JCI88647
   Xu KY, 2021, GUT, V70, P1486, DOI 10.1136/gutjnl-2020-323263
   Yang H, 2021, J CEREBR BLOOD F MET, V41, P958, DOI 10.1177/0271678X20942613
   Yu XB, 2021, FRONT MICROBIOL, V12, DOI 10.3389/fmicb.2021.647304
   Zemgulyte G, 2021, PHARMACEUTICALS-BASE, V14, DOI 10.3390/ph14040312
   Zhang PP, 2021, FREE RADICAL BIO MED, V162, P104, DOI 10.1016/j.freeradbiomed.2020.11.032
   Zhao XR, 2014, TRANSL STROKE RES, V5, P554, DOI 10.1007/s12975-014-0341-2
   Zhu HM, 2019, PROG NEUROBIOL, V178, P6, DOI 10.1016/j.pneurobio.2019.03.003
   Zhuang JF, 2021, TRANSL STROKE RES, V12, P660, DOI 10.1007/s12975-020-00842-9
NR 50
TC 4
Z9 4
U1 5
U2 21
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1662-5102
J9 FRONT CELL NEUROSCI
JI Front. Cell. Neurosci.
PD JAN 18
PY 2022
VL 15
AR 789471
DI 10.3389/fncel.2021.789471
PG 15
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA YR5LR
UT WOS:000750034200001
PM 35115909
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Huang, SW
   Ou, YC
   Tang, KS
   Yu, HR
   Huang, LT
   Tain, YL
   Lin, IC
   Sheen, JM
   Hou, CY
   Tsai, CC
   Tiao, MM
AF Huang, Szu-Wei
   Ou, Yu-Che
   Tang, Kuo-Shu
   Yu, Hong-Ren
   Huang, Li-Tung
   Tain, You-Lin
   Lin, I-Chun
   Sheen, Jiunn-Ming
   Hou, Chih-Yao
   Tsai, Ching-Chou
   Tiao, Mao-Meng
TI Metformin ameliorates maternal high-fat diet-induced maternal dysbiosis
   and fetal liver apoptosis
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Article
DE Fatty liver; High-fat diet; Pregnancy; Metformin; Microbiota; Apoptosis
ID RAT MODEL; PREGNANCY; INFLAMMATION; EXPRESSION; EXPOSURE; WEIGHT; HEALTH
AB Background The deleterious effect of maternal high-fat diet (HFD) on the fetal rat liver may cause later development of non-alcoholic fatty liver disease (NAFLD). The aim of this study was to evaluate the effect of maternal HFD-induced maternal hepatic steatosis and dysbiosis on the fetal liver and intestines, and the effect of prenatal metformin in a rat model. Methods Sprague-Dawley rats were assigned to three groups (N = 6 in each group). Before mating, the rats were randomly assigned to HFD or normal-chow diet (NCD) group for 7 weeks. After mating, the HFD group rats were continued with high-fat diet during pregnancy and some of the HFD group rats were co-treated with metformin (HFMf) via drinking water during pregnancy. All maternal rats and their fetuses were sacrificed on gestational day 21. The liver and intestinal tissues of both maternal and fetal rats were analyzed. In addition, microbial deoxyribonucleic acid extracted from the maternal fecal samples was analyzed. Results HFD resulted in maternal weight gain during pregnancy, intrahepatic lipid accumulation, and change in the serum short-chain fatty acid profile, intestinal tight junctions, and dysbiosis in maternal rats. The effect of HFD on maternal rats was alleviated by prenatal metformin, which also ameliorated inflammation and apoptosis in the fetal liver and intestines. Conclusions This study demonstrated the beneficial effects of prenatal metformin on maternal liver steatosis, focusing on the gut-liver axis. In addition, the present study indicates that prenatal metformin could ameliorate maternal HFD-induced inflammation and apoptosis in the fetal liver and intestines. This beneficial effect of in-utero exposure of metformin on fetal liver and intestines has not been reported. This study supports the use of prenatal metformin for pregnant obese women.
C1 [Huang, Szu-Wei; Tsai, Ching-Chou] Chang Gung Univ, Kaohsiung Chang Gung Mem Hosp, Dept Obstet & Gynecol, Coll Med, Kaohsiung, Taiwan.
   [Ou, Yu-Che] Chiayi Chang Gung Mem Hosp, Dept Obstet & Gynecol, Chiayi, Taiwan.
   [Tang, Kuo-Shu; Yu, Hong-Ren; Huang, Li-Tung; Tain, You-Lin; Lin, I-Chun; Tiao, Mao-Meng] Chang Gung Univ, Kaohsiung Chang Gung Mem Hosp, Dept Pediat, Coll Med, Kaohsiung, Taiwan.
   [Sheen, Jiunn-Ming] Chiayi Chang Gung Mem Hosp, Dept Pediat, Chiayi, Taiwan.
   [Hou, Chih-Yao] Natl Kaohsiung Univ Sci & Technol, Dept Seafood Sci, Kaohsiung, Taiwan.
   [Tsai, Ching-Chou] Kaohsiung Med Univ, Grad Inst Clin Med, Kaohsiung, Taiwan.
C3 Chang Gung Memorial Hospital; Chang Gung University; Chang Gung Memorial
   Hospital; Chang Gung Memorial Hospital; Chang Gung University; Chang
   Gung Memorial Hospital; National Kaohsiung University of Science &
   Technology; Kaohsiung Medical University
RP Tiao, MM (通讯作者)，Chang Gung Univ, Kaohsiung Chang Gung Mem Hosp, Dept Pediat, Coll Med, Kaohsiung, Taiwan.
EM tmm@cgmh.org.tw
RI HOU, CHIH YAO/S-4983-2018; Tain, You-Lin/H-2827-2019
OI Tain, You-Lin/0000-0002-7059-6407; Hou, Chih-Yao/0000-0002-8007-6077
FU Chang Gung Memorial Hospital, Taiwan [CMRPG8H1301, CMRPG8J0881, CMRP
   G8J0882, CMRPG8J0661]
FX This research was funded by grants (CMRPG8H1301, CMRPG8J0881, CMRP
   G8J0882 and CMRPG8J0661) from the Chang Gung Memorial Hospital, Taiwan.
   The funders had no role in the design of the study; in the collection,
   analyses, or interpretation of data; in the writing of the manuscript;
   or in the decision to publish the results.
CR Ahmad R, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-04989-8
   Ayonrinde OT, 2018, HEPATOLOGY, V67, P108, DOI 10.1002/hep.29347
   Bidlack WR., 2000, NUTR BIOCH, P419
   Brandt A, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-43228-0
   Canfora EE, 2015, NAT REV ENDOCRINOL, V11, P577, DOI 10.1038/nrendo.2015.128
   de la Rosa LC, 2015, PHARMACOL RES PERSPE, V3, DOI 10.1002/prp2.125
   Dodd JM, 2019, LANCET DIABETES ENDO, V7, P15, DOI [10.1016/S2213-8587(18)30310-3, 10.1016/s2213-8587(18)30310-3]
   Dornas W, 2019, PHARMACOL RES, V141, P418, DOI 10.1016/j.phrs.2019.01.026
   Ejtahed HS, 2019, EUR J ENDOCRINOL, V180, P165, DOI [10.1530/EJE-18-0826, 10.1530/eje-18-0826]
   FERGUSON-SMITH A C, 1988, Genomics, V2, P203, DOI 10.1016/0888-7543(88)90003-1
   Gilbert C, 2006, FERTIL STERIL, V86, P658, DOI 10.1016/j.fertnstert.2006.02.098
   Gomez-Zorita S, 2019, NUTRIENTS, V11, DOI 10.3390/nu11092156
   Grant WF, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0017261
   Green CJ, 2019, DIABETES OBES METAB, V21, P749, DOI 10.1111/dom.13592
   Gregg BE, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-23965-4
   Harada N, 2004, J SURG RES, V121, P159, DOI 10.1016/j.jss.2004.04.016
   Harris K, 2016, NUTR METAB, V13, DOI 10.1186/s12986-016-0115-9
   Huang YH, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17030369
   Hur KY, 2015, J DIABETES INVEST, V6, P600, DOI 10.1111/jdi.12328
   Irene P, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-11744-6
   Jiang M, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00665
   Kislal S, 2020, PRENATAL DIAG, V40, P1109, DOI 10.1002/pd.5784
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Lee S, 2018, J NUTR, V148, P209, DOI 10.1093/jn/nxx027
   Li S, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/4234061
   Li WF, 2018, J AGR FOOD CHEM, V66, P8015, DOI 10.1021/acs.jafc.8b02979
   Lindsay RS, 2017, DIABETOLOGIA, V60, P1612, DOI 10.1007/s00125-017-4351-y
   Liu F, 2014, INT J MOL MED, V33, P51, DOI 10.3892/ijmm.2013.1560
   Nascimento IBd Fleig R., 2020, OBESITY MED, DOI [10.1016/j.obmed.2020.100280, DOI 10.1016/J.OBMED.2020.100280]
   Obesity in Pregnancy, 2021, OBSTET GYNECOL, V137, pE128, DOI [10.1097/AOG.0000000000004395, DOI 10.1097/AOG.0000000000004395]
   Porras D, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.01813
   Poston L, 2016, LANCET DIABETES ENDO, V4, P1025, DOI 10.1016/S2213-8587(16)30217-0
   Roman A, 2013, AM J OBSTET GYNECOL, V208, pS13, DOI 10.1016/j.ajog.2012.10.192
   Salomaki H, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0115778
   Sivalingam VN, 2014, HUM REPROD UPDATE, V20, P853, DOI 10.1093/humupd/dmu037
   Song YM, 2015, AUTOPHAGY, V11, P46, DOI 10.4161/15548627.2014.984271
   STEVENSON BR, 1986, J CELL BIOL, V103, P755, DOI 10.1083/jcb.103.3.755
   Suzuki T, 2011, J BIOL CHEM, V286, P31263, DOI 10.1074/jbc.M111.238147
   Syngelaki A, 2016, NEW ENGL J MED, V374, P434, DOI 10.1056/NEJMoa1509819
   Tain YL, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19041066
   Tiao MM, 2018, LIPIDS HEALTH DIS, V17, DOI 10.1186/s12944-018-0824-3
   Tsai CM, 2014, TRANSL RES, V164, P452, DOI 10.1016/j.trsl.2014.07.005
   Varghese F, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0096801
   Wieckowska A, 2008, AM J GASTROENTEROL, V103, P1372, DOI 10.1111/j.1572-0241.2007.01774.x
   Xiao J, 2014, EUR J NUTR, V53, P187, DOI 10.1007/s00394-013-0516-8
   Xie Y, 2020, MOL MED REP, V21, P1133, DOI 10.3892/mmr.2020.10932
   Zambrano E, 2016, ARCH MED RES, V47, P1, DOI 10.1016/j.arcmed.2016.01.004
   Zheng J, 2015, FRONT MED-PRC, V9, P173, DOI 10.1007/s11684-015-0384-0
NR 48
TC 8
Z9 8
U1 2
U2 8
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1476-511X
J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD SEP 8
PY 2021
VL 20
IS 1
AR 100
DI 10.1186/s12944-021-01521-w
PG 16
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA UQ0ED
UT WOS:000695744700001
PM 34496884
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Olgun, A
AF Olgun, Abdullah
TI "Metformin-resistant" folic acid producing probiotics or folic acid
   against metformin's adverse effects like diarrhea
SO MEDICAL HYPOTHESES
LA English
DT Article
ID FOLATE
AB Metformin, first line medication in the treatment of type2 diabetes by millions of patients worldwide, causes gastrointestinal adverse effects (i.e. diarrhea) in approximately 30% of patients, frequently leading to discontinuation. Interestingly, metformin was reported to increase life span in a microscopic worm, Caenorhabditis elegans, by decreasing folate and methionine production of bacteria that this worm uses as a food source. Metformin can be expected to have a similar effect on some microorganisms of human gut microbiota. This can disturb the balance of gut microbiota and cause gastrointestinal adverse effects by altering folate production of some types of bacteria and suppress their growth. Metformin resistant probiotics can be discovered or generated by artificial evolution/selection, and used to prevent these adverse effects. These patients can also be managed with folate supplementation. (C) 2017 Elsevier Ltd. All rights reserved.
C1 [Olgun, Abdullah] Istanbul Kemerburgaz Univ, Fac Pharm, Dept Biochem, Kartaltepe Mah Incirli Cad 11, TR-34144 Istanbul, Turkey.
C3 Altinbas University
RP Olgun, A (通讯作者)，Istanbul Kemerburgaz Univ, Fac Pharm, Dept Biochem, Kartaltepe Mah Incirli Cad 11, TR-34144 Istanbul, Turkey.
EM abdullah.olgun@kemerburgaz.edu.tr
RI Olgun, Abdullah/A-5125-2013
OI Olgun, Abdullah/0000-0002-6976-9286
CR An HY, 2016, J ENDOCRINOL, V228, pR97, DOI 10.1530/JOE-15-0447
   Bonnet F, 2017, DIABETES OBES METAB, V19, P473, DOI 10.1111/dom.12854
   Bouchoucha M, 2011, DIABETES METAB, V37, P90, DOI 10.1016/j.diabet.2010.11.002
   Cabreiro F, 2013, CELL, V153, P228, DOI 10.1016/j.cell.2013.02.035
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Gould Milena, 2009, Curr Gastroenterol Rep, V11, P354, DOI 10.1007/s11894-009-0054-y
   Melchior WR, 1996, ANN PHARMACOTHER, V30, P158, DOI 10.1177/106002809603000210
   Rossi M, 2011, NUTRIENTS, V3, P118, DOI 10.3390/nu3010118
   Song YL, 2004, ANAEROBE, V10, P179, DOI 10.1016/j.anaerobe.2004.04.004
NR 9
TC 12
Z9 12
U1 0
U2 9
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PD SEP
PY 2017
VL 106
BP 33
EP 34
DI 10.1016/j.mehy.2017.07.009
PG 2
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA FF8TL
UT WOS:000409290600008
PM 28818268
DA 2023-06-08
ER

PT J
AU Wang, DM
   Liu, JY
   Zhong, L
   Ding, L
   Zhang, Q
   Yu, M
   Li, M
   Xiao, XH
AF Wang, Dongmei
   Liu, Jieying
   Zhong, Ling
   Ding, Lu
   Zhang, Qian
   Yu, Miao
   Li, Ming
   Xiao, Xinhua
TI Potential benefits of metformin and pioglitazone combination therapy via
   gut microbiota and metabolites in high-fat diet-fed mice
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE pioglitazone; metformin; combination therapy; gut microbiota;
   metabolites
ID INFLAMMATION
AB Metformin and pioglitazone monotherapy have been proven to alter gut microbiota in diabetes and obesity. The present study aimed to investigated whether the combined administration of pioglitazone and metformin achieved superior protective effects on high-fat diet (HFD)-fed obese mice and elucidated its molecular mechanism via the gut microbiota and its metabolites. C57BL/6 males were randomly divided into five groups: the control group, fed a normal control diet; the HFD group, fed an HFD; the metformin monotherapy group, fed an HFD and treated with metformin; the pioglitazone monotherapy group, fed an HFD and treated with pioglitazone; and the combination therapy group, fed an HFD and treated with metformin and pioglitazone combination therapy. The cecal contents were collected for 16S rDNA amplicon sequencing and untargeted metabolomics analysis. The results showed that the combination therapy of metformin and pioglitazone significantly improved insulin sensitivity and glucolipid metabolism in HFD-fed mice. Combination therapy markedly altered gut microbiota by increasing beneficial bacteria, such as Bifidobacterium, Christensenellaceae_R-7_group, Faecalibacterium and Roseburia, and decreasing harmful bacteria, such as Oscillibacter and Eubacterium_xylanophilum_group. Fecal metabolites were significantly changed in the combination therapy group, including a reduction in amino acid metabolism and augmentation of lipid metabolism, such as citrulline, sarcosine, D-glutamine, lipoxin A4, prostaglandin E2, stearidonic acid and lucidenic acid A. These results revealed that combined metformin and pioglitazone therapy had synergistic effects or at least have an additive effect on modifying gut microbiota and metabolites, closely associated with improved glucolipid metabolic parameters in HFD-fed mice, which provides novel evidence and promising targets for metformin and pioglitazone combination therapy in type 2 diabetes.
C1 [Wang, Dongmei; Liu, Jieying; Zhong, Ling; Ding, Lu; Zhang, Qian; Yu, Miao; Li, Ming; Xiao, Xinhua] Peking Union Med Coll & Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Endocrinol, NHC Key Lab Endocrinol, Beijing, Peoples R China.
   [Liu, Jieying] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Med Res Ctr, Beijing, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College; Peking Union Medical College Hospital;
   Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College; Peking Union Medical College Hospital
RP Xiao, XH (通讯作者)，Peking Union Med Coll & Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Endocrinol, NHC Key Lab Endocrinol, Beijing, Peoples R China.
EM xiaoxh2014@vip.163.com
RI Liu, Jieying/ADZ-7556-2022; Li, Ming/I-1323-2018
OI Li, Ming/0000-0002-8427-605X
FU National Natural Science Foundation of China; Beijing Natural Science
   Foundation [82170854, 81870579, 81900723, 81870545, 81570715];
   Fundamental Research Funds for the Central Universities [7202163];
   Beijing Municipal Science and Technology Commission [3332021094]; 
   [Z201100005520011]
FX This work was supported by the grants from National Natural Science
   Foundation of China (No. 82170854, 81870579, 81900723, 81870545,
   81570715), Beijing Natural Science Foundation (7202163), Fundamental
   Research Funds for the Central Universities (3332021094), and Beijing
   Municipal Science and Technology Commission (Z201100005520011).
CR Aggarwal H, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23010195
   Agus A, 2021, GUT, V70, P1174, DOI 10.1136/gutjnl-2020-323071
   Ahmadi S, 2020, J GERONTOL A-BIOL, V75, pE9, DOI 10.1093/gerona/glaa056
   Ahmadian M, 2013, NAT MED, V19, P557, DOI 10.1038/nm.3159
   Amer Diabet Assoc, 2021, DIABETES CARE, V44, pS111, DOI 10.2337/dc21-S009
   Bai J, 2016, J ETHNOPHARMACOL, V194, P717, DOI 10.1016/j.jep.2016.10.043
   Bethancourt HJ, 2022, AM J CLIN NUTR, V115, P1577, DOI 10.1093/ajcn/nqac029
   Bloomgarden Z, 2018, J DIABETES, V10, P350, DOI 10.1111/1753-0407.12645
   Borgeson E, 2015, CELL METAB, V22, P125, DOI 10.1016/j.cmet.2015.05.003
   Bokulich NA, 2013, NAT METHODS, V10, P57, DOI [10.1038/nmeth.2276, 10.1038/NMETH.2276]
   Caesar R, 2015, CELL METAB, V22, P658, DOI 10.1016/j.cmet.2015.07.026
   Cai J, 2022, CRIT REV FOOD SCI, V62, P6225, DOI 10.1080/10408398.2021.1898336
   Dalile B, 2019, NAT REV GASTRO HEPAT, V16, P461, DOI 10.1038/s41575-019-0157-3
   Deeks ED, 2006, DRUGS, V66, P1863, DOI 10.2165/00003495-200666140-00007
   Duan RQ, 2022, FOOD CHEM TOXICOL, V164, DOI 10.1016/j.fct.2022.112948
   Gurung M, 2020, EBIOMEDICINE, V51, DOI 10.1016/j.ebiom.2019.11.051
   Haraguchi G, 2008, INTENS CARE MED, V34, P1304, DOI 10.1007/s00134-008-1024-9
   Ju TT, 2019, ISME J, V13, P1520, DOI 10.1038/s41396-019-0364-5
   Ke HR, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.726707
   Kleerebezem M, 2020, FEMS MICROBIOL REV, V44, P804, DOI 10.1093/femsre/fuaa033
   Kong C, 2019, NUTRITION, V60, P175, DOI 10.1016/j.nut.2018.10.002
   Li JM, 2019, MICROBIOME, V7, DOI 10.1186/s40168-019-0713-7
   Li XP, 2022, MOL NUTR FOOD RES, V66, DOI 10.1002/mnfr.202101015
   Li XX, 2020, HEPATOL RES, V50, P5, DOI 10.1111/hepr.13444
   Li YR, 2017, LIPIDS HEALTH DIS, V16, DOI 10.1186/s12944-017-0574-7
   Liu DM, 2022, FOOD FUNCT, V13, P356, DOI [10.1039/D1FO02181H, 10.1039/d1fo02181h]
   Liu JY, 2022, FRONT MICROBIOL, V13, DOI 10.3389/fmicb.2022.809642
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   McCreight LJ, 2016, DIABETOLOGIA, V59, P426, DOI 10.1007/s00125-015-3844-9
   Mueller NT, 2021, DIABETES CARE, V44, P1462, DOI 10.2337/dc20-2257
   Peng J, 2022, J INFLAMM RES, V15, P1457, DOI 10.2147/JIR.S352863
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Qiu XX, 2021, INT J OBESITY, V45, P143, DOI 10.1038/s41366-020-00712-2
   Segata N, 2011, GENOME BIOL, V12, DOI 10.1186/gb-2011-12-6-r60
   Shen JH, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.890277
   Su XH, 2022, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.808867
   Sultana MF, 2022, FRONT MICROBIOL, V13, DOI 10.3389/fmicb.2022.900948
   Sun H, 2022, DIABETES RES CLIN PR, V183, DOI 10.1016/j.diabres.2021.109119
   Wang CQ, 2022, JCI INSIGHT, V7, DOI 10.1172/jci.insight.153755
   Wang HQ, 2016, BIOMED PHARMACOTHER, V84, P1617, DOI 10.1016/j.biopha.2016.10.113
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Xue LJ, 2020, WORLD J GASTROENTERO, V26, P7299, DOI 10.3748/wjg.v26.i46.7299
   Xue XY, 2021, CHIN MED-UK, V16, DOI 10.1186/s13020-021-00524-0
   Yang CC, 2021, FOOD FUNCT, V12, P9793, DOI [10.1039/D1FO01468D, 10.1039/d1fo01468d]
   Zeng SL, 2020, SCI ADV, V6, DOI 10.1126/sciadv.aax6208
   Zheng Y, 2018, NAT REV ENDOCRINOL, V14, P88, DOI 10.1038/nrendo.2017.151
   Zou XY, 2022, ANIMAL, V16, DOI 10.1016/j.animal.2022.100474
NR 47
TC 1
Z9 1
U1 6
U2 7
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD OCT 11
PY 2022
VL 13
AR 1004617
DI 10.3389/fphar.2022.1004617
PG 15
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 5T7BC
UT WOS:000876016000001
PM 36304148
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Chen, S
   Gan, DH
   Lin, SX
   Zhong, YM
   Chen, MJ
   Zou, XN
   Shao, ZW
   Xiao, GZ
AF Chen, Sheng
   Gan, Donghao
   Lin, Sixiong
   Zhong, Yiming
   Chen, Mingjue
   Zou, Xuenong
   Shao, Zengwu
   Xiao, Guozhi
TI Metformin in aging and aging-related diseases: clinical applications and
   relevant mechanisms
SO THERANOSTICS
LA English
DT Review
DE Metformin; aging; aging-related diseases; clinical application;
   molecular mechanism
ID LONG-TERM METFORMIN; DNA-DAMAGE; KINASE ACTIVATION; GUT MICROBIOTA;
   PROTEIN-KINASE; DOUBLE-BLIND; AMINO-ACIDS; RISK; CANCER; INSULIN
AB Aging is a natural process, which plays a critical role in the pathogenesis of a variety of diseases, i.e., aging-related diseases, such as diabetes, osteoarthritis, Alzheimer disease, cardiovascular diseases, cancers, obesity and other metabolic abnormalities. Metformin, the most widely used antidiabetic drug, has been reported to delay aging and display protective effect on attenuating progression of various aging-related diseases by impacting key hallmark events of aging, including dysregulated nutrient sensing, loss of proteostasis, mitochondrial dysfunction, altered intercellular communication, telomere attrition, genomic instability, epigenetic alterations, stem cell exhaustion and cellular senescence. In this review, we provide updated information and knowledge on applications of metformin in prevention and treatment of aging and aging-related diseases. We focus our discussions on the roles and underlying mechanisms of metformin in modulating aging and treating aging-related diseases.
C1 [Chen, Sheng; Shao, Zengwu] Huazhong Univ Sci & Technol, Union Hosp, Dept Orthopaed, Tongji Med Coll, Wuhan 430022, Peoples R China.
   [Chen, Sheng; Gan, Donghao; Lin, Sixiong; Zhong, Yiming; Chen, Mingjue; Xiao, Guozhi] Southern Univ Sci & Technol, Dept Biochem, Sch Med, Shenzhen Key Lab Cell Microenvironm,Guangdong Pro, Shenzhen 518055, Peoples R China.
   [Lin, Sixiong; Zou, Xuenong] Sun Yat Sen Univ, Guangdong Prov Key Lab Orthopaed & Traumatol, Dept Spine Surg, Affiliated Hosp 1, Guangzhou 510080, Peoples R China.
C3 Huazhong University of Science & Technology; Southern University of
   Science & Technology; Sun Yat Sen University
RP Shao, ZW (通讯作者)，Huazhong Univ Sci & Technol, Union Hosp, Dept Orthopaed, Tongji Med Coll, Wuhan 430022, Peoples R China.; Xiao, GZ (通讯作者)，Southern Univ Sci & Technol, Dept Biochem, Sch Med, Shenzhen Key Lab Cell Microenvironm,Guangdong Pro, Shenzhen 518055, Peoples R China.
EM szwpro@163.com; xiaogz@sustech.edu.cn
RI Lin, Sixiong/HNC-3076-2023
OI Lin, Sixiong/0000-0001-7155-5044
FU National Key Research and Development Program of China [2019YFA0906004];
   National Natural Science Foundation of China [81991513, 81870532];
   Guangdong Provincial Science and Technology Innovation Council
   [2017B030301018]
FX We apologize to the authors whose studies may have been overlooked in
   this review article. This work was supported, in part, by the National
   Key Research and Development Program of China Grants (2019YFA0906004) ,
   the National Natural Science Foundation of China Grants (81991513 and
   81870532) and the Guangdong Provincial Science and Technology Innovation
   Council Grant (2017B030301018) .
CR Aatsinki SM, 2014, BRIT J PHARMACOL, V171, P2351, DOI 10.1111/bph.12585
   Amin S, 2016, AM J GASTROENTEROL, V111, P1350, DOI 10.1038/ajg.2016.288
   Andrzejewski S, 2017, CELL METAB, V26, P778, DOI 10.1016/j.cmet.2017.09.006
   Anisimov VN, 2013, CRIT REV ONCOL HEMAT, V87, P201, DOI 10.1016/j.critrevonc.2013.01.005
   Arrieta O, 2019, JAMA ONCOL, V5, DOI 10.1001/jamaoncol.2019.2553
   Bailey CJ, 2017, DIABETOLOGIA, V60, P1566, DOI 10.1007/s00125-017-4318-z
   Batsis JA, 2018, NAT REV ENDOCRINOL, V14, P513, DOI 10.1038/s41574-018-0062-9
   Belloni L, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-31835-2
   Bergmark BA, 2019, CIRCULATION, V140, P1004, DOI 10.1161/CIRCULATIONAHA.119.040144
   de Jesus BB, 2011, AGING CELL, V10, P604, DOI 10.1111/j.1474-9726.2011.00700.x
   Bettedi L, 2017, BIOGERONTOLOGY, V18, P913, DOI 10.1007/s10522-017-9724-6
   Bharath LP, 2020, CELL METAB, V32, P44, DOI 10.1016/j.cmet.2020.04.015
   Bjorkhem-Bergman L, 2011, J PSYCHOPHARMACOL, V25, P299, DOI 10.1177/0269881109353461
   Blackburn EH, 2015, SCIENCE, V350, P1193, DOI 10.1126/science.aab3389
   Bodmer M, 2010, DIABETES CARE, V33, P1304, DOI 10.2337/dc09-1791
   Cai H, 2020, INT J MOL MED, V45, P715, DOI 10.3892/ijmm.2020.4453
   Campagnoli C, 2013, CLIN BREAST CANCER, V13, P433, DOI 10.1016/j.clbc.2013.08.012
   Campbell JM, 2017, AGEING RES REV, V40, P31, DOI 10.1016/j.arr.2017.08.003
   Campisi J, 2019, NATURE, V571, P183, DOI 10.1038/s41586-019-1365-2
   Rosa ECCC, 2018, DIABETES RES CLIN PR, V135, P30, DOI 10.1016/j.diabres.2017.10.020
   Chang YT, 2018, TRANSL ONCOL, V11, P535, DOI 10.1016/j.tranon.2018.02.012
   Charytan DM, 2019, DIABETES OBES METAB, V21, P1199, DOI 10.1111/dom.13642
   Chen DH, 2016, CELL DEATH DIS, V7, DOI 10.1038/cddis.2016.334
   Chen EC, 2015, MOL PHARMACOL, V88, P75, DOI 10.1124/mol.114.096776
   Chen J, 2017, ELIFE, V6, DOI 10.7554/eLife.31268
   Chen MM, 2021, J CELL MOL MED, V25, P8376, DOI 10.1111/jcmm.16797
   Chen S, 2022, BONE RES, V10, DOI 10.1038/s41413-021-00179-5
   Chen S, 2020, FRONT CELL DEV BIOL, V8, DOI 10.3389/fcell.2020.00127
   Chen X, 2015, TUMOR BIOL, V36, P9873, DOI 10.1007/s13277-015-3751-1
   Cheng X, 2020, CELL METAB, V32, P537, DOI 10.1016/j.cmet.2020.08.013
   Chinnapaka S., 2021, BIOMEDICINES, V9, P1782
   Crouse AB, 2021, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.600439
   Cuyas E, 2018, ONCOGENE, V37, P963, DOI 10.1038/onc.2017.367
   Cuyas E, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00657
   Dallaglio K, 2014, CARCINOGENESIS, V35, P1055, DOI 10.1093/carcin/bgu001
   Davidson JA, 2004, DRUG SAFETY, V27, P1205, DOI 10.2165/00002018-200427150-00004
   de Araujo AA, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0183506
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   de Maranon AM, 2021, ANTIOXID REDOX SIGN, V35, P377, DOI 10.1089/ars.2021.0019
   DEFRONZO RA, 1995, NEW ENGL J MED, V333, P541, DOI 10.1056/NEJM199508313330902
   Deng J, 2021, SIGNAL TRANSDUCT TAR, V6, DOI 10.1038/s41392-021-00493-8
   Deng M, 2020, PATHOL RES PRACT, V216, DOI 10.1016/j.prp.2019.152775
   Deng MY, 2020, FRONT PHARMACOL, V11, DOI 10.3389/fphar.2020.00635
   DeWaal D, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-017-02733-4
   Diman A, 2016, SCI ADV, V2, DOI 10.1126/sciadv.1600031
   Ding Y, 2021, THERANOSTICS, V11, P9376, DOI 10.7150/thno.64706
   Duca FA, 2015, NAT MED, V21, P506, DOI 10.1038/nm.3787
   Eppenga WL, 2014, DIABETES CARE, V37, P2218, DOI 10.2337/dc13-3023
   Fang JQ, 2018, AGING CELL, V17, DOI 10.1111/acel.12765
   Feng J, 2022, PHARMACOL RES, V177
   Feng XJ, 2021, FRONT IMMUNOL, V12, DOI 10.3389/fimmu.2021.682853
   Flory J, 2019, JAMA-J AM MED ASSOC, V321, P1926, DOI 10.1001/jama.2019.3805
   Foretz M, 2014, CELL METAB, V20, P953, DOI 10.1016/j.cmet.2014.09.018
   Foretz M, 2010, J CLIN INVEST, V120, P2355, DOI 10.1172/JCI40671
   Fullerton MD, 2013, NAT MED, V19, P1649, DOI 10.1038/nm.3372
   Gallagher L, 2020, ARTHRITIS RHEUMATOL, V72, P896, DOI 10.1002/art.41190
   Gao ZG, 2020, NAT METAB, V2, DOI 10.1038/s42255-020-00320-4
   Garber AJ, 1997, AM J MED, V103, P491, DOI 10.1016/S0002-9343(97)00254-4
   Garcia-Calzon S, 2020, SCI TRANSL MED, V12, DOI 10.1126/scitranslmed.aaz1803
   Garcia-Martin I, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0208533
   Gardiner SJ, 2003, CLIN PHARMACOL THER, V73, P71, DOI 10.1067/mcp.2003.9
   Geerling JJ, 2014, DIABETES, V63, P880, DOI 10.2337/db13-0194
   Goldberg RB, 2017, CIRCULATION, V136, P52, DOI 10.1161/CIRCULATIONAHA.116.025483
   Goncharov DA, 2018, AM J RESP CRIT CARE, V198, P681, DOI 10.1164/rccm.201801-0022LE
   Han YC, 2019, AGING-US, V11, P10252, DOI 10.18632/aging.102453
   He L, 2020, TRENDS PHARMACOL SCI, V41, P868, DOI 10.1016/j.tips.2020.09.001
   HERMANN LS, 1991, DIABETES METAB, V17, P201
   Hou YJ, 2019, NAT REV NEUROL, V15, P565, DOI 10.1038/s41582-019-0244-7
   Huang JJ, 2021, GERONTOLOGY, V67, P60, DOI 10.1159/000511362
   Imfeld P, 2012, J AM GERIATR SOC, V60, P916, DOI 10.1111/j.1532-5415.2012.03916.x
   Induri SNR, 2022, ANNU REV PHARMACOL, V62, P85, DOI 10.1146/annurev-pharmtox-051920-093829
   Inzucchi SE, 1998, NEW ENGL J MED, V338, P867, DOI 10.1056/NEJM199803263381303
   Jagannathan S, 2015, LEUKEMIA, V29, P2184, DOI 10.1038/leu.2015.157
   Jang JY, 2018, J CLIN INVEST, V128, P3662, DOI 10.1172/JCI120842
   Jaskelioff M, 2011, NATURE, V469, P102, DOI 10.1038/nature09603
   Jia W, 2022, DIS MARKERS, V2022
   Jiang X, 2020, OXID MED CELL LONGEV, V2020, DOI 10.1155/2020/8708236
   Justice JN, 2018, CARDIOVASC ENDOCR ME, V7, P80, DOI 10.1097/XCE.0000000000000159
   Kalender A, 2010, CELL METAB, V11, P390, DOI 10.1016/j.cmet.2010.03.014
   Kanazawa I, 2008, BIOCHEM BIOPH RES CO, V375, P414, DOI 10.1016/j.bbrc.2008.08.034
   Kang J, 2021, J THORAC ONCOL, V16, P76, DOI 10.1016/j.jtho.2020.08.021
   Karnewar S, 2018, BBA-MOL BASIS DIS, V1864, P1115, DOI 10.1016/j.bbadis.2018.01.018
   Kim EK, 2016, MEDIAT INFLAMM, V2016, DOI 10.1155/2016/5813030
   Kincius M, 2020, AGING MALE, V23, P1333, DOI 10.1080/13685538.2020.1766013
   Kita Y, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0043056
   Koffert JP, 2017, DIABETES RES CLIN PR, V131, P208, DOI 10.1016/j.diabres.2017.07.015
   Konopka AR, 2019, AGING CELL, V18, DOI 10.1111/acel.12880
   Kordes S, 2015, LANCET ONCOL, V16, P839, DOI 10.1016/S1470-2045(15)00027-3
   Kuan YC, 2017, PROG NEURO-PSYCHOPH, V79, P77, DOI 10.1016/j.pnpbp.2017.06.002
   Kuang YC, 2020, BIOGERONTOLOGY, V21, P13, DOI 10.1007/s10522-019-09838-x
   Kulkarni AS, 2020, CELL METAB, V32, P15, DOI 10.1016/j.cmet.2020.04.001
   Kulkarni AS, 2018, AGING CELL, V17, DOI 10.1111/acel.12723
   Lahiguera A, 2020, EMBO MOL MED, V12, DOI 10.15252/emmm.201911217
   Lai YC, 2016, CIRCULATION, V133, P717, DOI 10.1161/CIRCULATIONAHA.115.018935
   Lamming DW, 2012, SCIENCE, V335, P1638, DOI 10.1126/science.1215135
   Larsen AH, 2020, EUR J HEART FAIL, V22, P1628, DOI 10.1002/ejhf.1656
   Le Couteur DG, 2021, CELL METAB, V33, P2367, DOI 10.1016/j.cmet.2021.10.016
   Le Pelletier L, 2021, ELIFE, P10
   Lee CK, 2016, ANN SURG, V263, P96, DOI 10.1097/SLA.0000000000001086
   Lee S, 2021, NATURE, V599, P283, DOI 10.1038/s41586-021-03995-1
   Li J, 2020, ANN RHEUM DIS, V79, P635, DOI 10.1136/annrheumdis-2019-216713
   Li YY, 2018, EXP GERONTOL, V105, P118, DOI 10.1016/j.exger.2017.10.027
   Li ZH, 2018, ONCOL LETT, V15, P7948, DOI 10.3892/ol.2018.8297
   Liao ZW, 2021, BIOMATERIALS, V274, DOI 10.1016/j.biomaterials.2021.120850
   Lin HZ, 2000, NAT MED, V6, P998, DOI 10.1038/79697
   Lopez-Otin C, 2013, CELL, V153, P1194, DOI 10.1016/j.cell.2013.05.039
   Lovvik TS, 2019, LANCET DIABETES ENDO, V7, P256, DOI 10.1016/S2213-8587(19)30002-6
   Lu CH, 2020, J CLIN MED, P9
   Luizon MR, 2016, PLOS GENET, V12, DOI 10.1371/journal.pgen.1006449
   Luo J, 2020, AGEING RES REV, V57, DOI 10.1016/j.arr.2019.100982
   Luo P, 2020, AM J TROP MED HYG, V103, P69, DOI 10.4269/ajtmh.20-0375
   Ma LW, 2019, J EXP CLIN CANC RES, V38, DOI 10.1186/s13046-019-1090-6
   Madiraju AK, 2018, NAT MED, V24, P1384, DOI 10.1038/s41591-018-0125-4
   Madiraju AK, 2014, NATURE, V510, P542, DOI 10.1038/nature13270
   Mai QG, 2011, J CELL BIOCHEM, V112, P2902, DOI 10.1002/jcb.23206
   Martin-Montalvo A, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms3192
   Melzer D, 2020, NAT REV GENET, V21, P88, DOI 10.1038/s41576-019-0183-6
   Menendez JA, 2011, AGING-US, V3, P1063, DOI 10.18632/aging.100407
   Moore EM, 2013, DIABETES CARE, V36, P2981, DOI 10.2337/dc13-0229
   Murphy MP, 2018, NAT REV DRUG DISCOV, V17, P865, DOI 10.1038/nrd.2018.174
   Na HJ, 2018, BIOCHEM BIOPH RES CO, V498, P18, DOI 10.1016/j.bbrc.2018.02.191
   Na HJ, 2013, MECH AGEING DEV, V134, P381, DOI 10.1016/j.mad.2013.07.003
   Nafisa A, 2018, PHARMACOL THERAPEUT, V192, P150, DOI 10.1016/j.pharmthera.2018.07.007
   Neumann B, 2019, CELL STEM CELL, V25, P473, DOI 10.1016/j.stem.2019.08.015
   Nie LT, 2017, MOL CELL PROTEOMICS, V16, P1324, DOI [10.1074/mcp.M117.067553, 10.1074/mcp.m117.067553]
   Niedernhofer LJ, 2018, ANNU REV BIOCHEM, V87, P295, DOI 10.1146/annurev-biochem-062917-012239
   Nies AT, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0022163
   Ning WX, 2021, CELL STEM CELL, V28, P436, DOI 10.1016/j.stem.2020.11.002
   Niu C, 2019, AUTOPHAGY, V15, P843, DOI 10.1080/15548627.2019.1569913
   Noren Hooten N, 2016, AGING CELL, V15, P572, DOI 10.1111/acel.12469
   O'Toole PW, 2015, SCIENCE, V350, P1214, DOI 10.1126/science.aac8469
   Palmer AK, 2019, DIABETOLOGIA, V62, P1835, DOI 10.1007/s00125-019-4934-x
   Park MJ, 2019, J IMMUNOL, V203, P127, DOI 10.4049/jimmunol.1800006
   Park YMM, 2021, ANN ONCOL, V32, P351, DOI 10.1016/j.annonc.2020.12.008
   Pernicova I, 2020, LANCET DIABETES ENDO, V8, P278, DOI 10.1016/S2213-8587(20)30021-8
   Pickard JM, 2017, IMMUNOL REV, V279, P70, DOI 10.1111/imr.12567
   Postler TS, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-97441-x
   Preiss D, 2016, DIABETIC MED, V33, P1569, DOI 10.1111/dme.13097
   Pryor R, 2019, CELL, V178, P1299, DOI 10.1016/j.cell.2019.08.003
   Qin X, 2018, J CELL BIOCHEM, V119, P1074, DOI 10.1002/jcb.26275
   Ren J, 2018, TRENDS PHARMACOL SCI, V39, P1064, DOI 10.1016/j.tips.2018.10.005
   Repas J, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-98642-0
   Sabit Hussein, 2018, Asian Pac J Cancer Prev, V19, P2991
   Samaras K, 2020, DIABETES CARE, V43, P2691, DOI 10.2337/dc20-0892
   Sanchis A, 2019, EXP MOL MED, V51, DOI 10.1038/s12276-019-0264-9
   Sardu C, 2019, DIABETES CARE, V42, P1946, DOI 10.2337/dc18-2356
   Shaw RJ, 2005, SCIENCE, V310, P1642, DOI 10.1126/science.1120781
   Smieszek A, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18040872
   Smith HJ, 2020, DEV CELL, V54, P196, DOI 10.1016/j.devcel.2020.06.011
   Soliman PT, 2020, CLIN CANCER RES, V26, P581, DOI 10.1158/1078-0432.CCR-19-0471
   Soukas AA, 2019, TRENDS ENDOCRIN MET, V30, P745, DOI 10.1016/j.tem.2019.07.015
   Steenblock C, 2021, LANCET DIABETES ENDO, V9, P786, DOI 10.1016/S2213-8587(21)00244-8
   Sultuybek GK, 2019, CLIN EXP PHARMACOL P, V46, P413, DOI 10.1111/1440-1681.13073
   Suwa M, 2006, J APPL PHYSIOL, V101, P1685, DOI 10.1152/japplphysiol.00255.2006
   Svensson E, 2017, DIABETES CARE, V40, P800, DOI 10.2337/dc16-2271
   Tang BL, 2020, REV NEUROSCIENCE, V31, P297, DOI 10.1515/revneuro-2019-0072
   Tang GJ, 2018, INT J ONCOL, V52, P1899, DOI 10.3892/ijo.2018.4343
   Tanokashira D, 2019, NEURAL REGEN RES, V14, P1330, DOI 10.4103/1673-5374.253535
   Thakur S, 2018, CLIN CANCER RES, V24, P4030, DOI 10.1158/1078-0432.CCR-17-3167
   Thevaranjan N, 2017, CELL HOST MICROBE, V21, P455, DOI 10.1016/j.chom.2017.03.002
   Tian R, 2019, BBA-MOL BASIS DIS, V1865, P1701, DOI 10.1016/j.bbadis.2019.04.009
   Tizazu AM, 2019, FRONT PHYSIOL, V10, DOI 10.3389/fphys.2019.00572
   Tseng CH, 2021, BONE, V151, DOI 10.1016/j.bone.2021.116037
   Tseng CH, 2016, EUR J CANCER, V52, P19, DOI 10.1016/j.ejca.2015.09.027
   Tseng HW, 2019, CANCERS, V11, DOI 10.3390/cancers11020209
   Turacli ID, 2018, BIOCHIMIE, V154, P62, DOI 10.1016/j.biochi.2018.08.002
   Valencia WM, 2017, DIABETOLOGIA, V60, P1630, DOI 10.1007/s00125-017-4349-5
   van den Bosch MHJ, 2021, OSTEOARTHR CARTILAGE, V29, P143, DOI 10.1016/j.joca.2020.10.006
   Van Nostrand JL, 2020, GENE DEV, V34, P1330, DOI 10.1101/gad.339895.120
   Vancura A, 2018, TRENDS PHARMACOL SCI, V39, P867, DOI 10.1016/j.tips.2018.07.006
   Vazquez-Martin A, 2011, CELL CYCLE, V10, P1499, DOI 10.4161/cc.10.9.15423
   Vestergaard P, 2005, DIABETOLOGIA, V48, P1292, DOI 10.1007/s00125-005-1786-3
   Virtanen A, 2020, PREGNANCY HYPERTENS, V22, P7, DOI 10.1016/j.preghy.2020.06.008
   Wahlqvist ML, 2012, PARKINSONISM RELAT D, V18, P753, DOI 10.1016/j.parkreldis.2012.03.010
   Walford GA, 2013, METABOLISM, V62, P1772, DOI 10.1016/j.metabol.2013.07.003
   Wang QL, 2020, AM J GASTROENTEROL, V115, P73, DOI 10.14309/ajg.0000000000000478
   Wang QL, 2017, DIABETES, V66, P193, DOI 10.2337/db16-0915
   Wang R, 2017, BMJ-BRIT MED J, V356, DOI 10.1136/bmj.j138
   Wang SL, 2018, DIABETES, V67, P98, DOI 10.2337/db17-0503
   Wang Y, 2019, CELL REP, V29, P1511, DOI 10.1016/j.celrep.2019.09.070
   Wang YY, 2019, ARTHRITIS RES THER, V21, DOI 10.1186/s13075-019-1915-x
   Williams CC, 2013, J HEALTH CARE POOR U, V24, P93, DOI 10.1353/hpu.2013.0044
   Wu H, 2021, BIOCHEM BIOPH RES CO, V557, P334, DOI 10.1016/j.bbrc.2021.04.029
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Wulffele MG, 2002, DIABETES CARE, V25, P2133, DOI 10.2337/diacare.25.12.2133
   Xiao Y, 2022, AGING CELL, V21, DOI 10.1111/acel.13567
   Xiong WF, 2021, CELL DEATH DIS, V12, DOI 10.1038/s41419-021-04235-0
   Xu H, 2016, J ENDOCRINOL, V229, P133, DOI 10.1530/JOE-15-0409
   Xu T, 2015, DIABETES CARE, V38, P1858, DOI 10.2337/dc15-0658
   Xu XY, 2021, PROTEIN CELL, V12, P769, DOI 10.1007/s13238-021-00858-3
   Yerevanian A, 2019, CURR OBES REP, V8, P156, DOI 10.1007/s13679-019-00335-3
   Yuan J, 2021, FRONT CARDIOVASC MED, V8, DOI 10.3389/fcvm.2021.686293
   Zhang X, 2015, SCI REP-UK, V5, DOI 10.1038/srep14405
   Zhang YF, 2014, DIABETES CARE, V37, P2804, DOI 10.2337/dc14-0090
   Zhao B, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/9290728
   Zhong T, 2017, ONCOGENE, V36, P2345, DOI 10.1038/onc.2016.391
   Zhou GC, 2001, J CLIN INVEST, V108, P1167, DOI 10.1172/JCI200113505
   Zhou JB, 2020, METABOLISM, V109, DOI 10.1016/j.metabol.2020.154265
   Zhou PT, 2017, ONCOTARGET, V8, P25242, DOI 10.18632/oncotarget.15692
NR 199
TC 9
Z9 9
U1 10
U2 31
PU IVYSPRING INT PUBL
PI LAKE HAVEN
PA PO BOX 4546, LAKE HAVEN, NSW 2263, AUSTRALIA
SN 1838-7640
J9 THERANOSTICS
JI Theranostics
PY 2022
VL 12
IS 6
BP 2722
EP 2740
DI 10.7150/thno.71360
PG 19
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 0F8SW
UT WOS:000777626900017
PM 35401820
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Gutierrez-Repiso, C
   Moreno-Indias, I
   Martin-Nunez, GM
   Ho-Plagaro, A
   Rodriguez-Canete, A
   Gonzalo, M
   Garcia-Fuentes, E
   Tinahones, FJ
AF Gutierrez-Repiso, Carolina
   Moreno-Indias, Isabel
   Martin-Nunez, Gracia M.
   Ho-Plagaro, Ailec
   Rodriguez-Canete, Alberto
   Gonzalo, Monserrat
   Garcia-Fuentes, Eduardo
   Tinahones, Francisco J.
TI Mucosa-associated microbiota in the jejunum of patients with morbid
   obesity: alterations in states of insulin resistance and metformin
   treatment
SO SURGERY FOR OBESITY AND RELATED DISEASES
LA English
DT Article
DE Jejunum; Microbiota; Morbid obesity; HOMA-IR; Metformin
ID GUT MICROBIOTA; OVERWEIGHT; DIVERSITY; SEQUENCE; HEALTHY; SAMPLES; BOWEL
AB Background: Stool samples have been widely used to evaluate gut microbiota; however, little is known about the composition of human small intestinal microbiota and the alterations provoked by insulin resistance.
   Objective: To describe the composition of jejunal microbiota in morbidly obese patients, as well as its link with insulin resistance and metformin treatment.
   Setting: Virgen de la Victoria University Hospital and Regional University Hospital, Malaga, Spain.
   Methods: Jejunal biopsies from 46 morbidly obese patients were analyzed by next-generation sequencing method. Patients were classified in the following 3 groups: low homeostasis model assessment of insulin resistance index (HOMA-IR) value, high HOMA-IR value, and metformin-treated type 2 diabetes patients (T2D-metf).
   Results: Richness (q = .011) together with Proteobacteria (W = 2), Fusobacteria (W 5 2), and Bacteroidetes (W = 1) phyla were significantly higher in high HOMA-IR compared with low HOMA-IR group. At family level, several differences were found between low HOMA-IR and T2D-metf group, being the most important the higher abundance of Halomonadacea in T2D-metf group (W = 22). PICRUSt analysis showed that predicted genes involved in trimethylamine-N-oxide biosynthesis pathway could be increased in jejunal microbiota of T2D-metf group compared with the low HOMA-IR group, while indole biosynthesis pathway could be increased in the low HOMA-IR group compared with the high HOMA-IR group.
   Conclusion: An increase in richness and an enrichment in Proteobacteria, Fusobacteria, and Bacteroidetes was observed in jejunal from morbidly obese patients with high insulin resistance. Halomonadaceae family was significantly increased in metformin-treated patients. Functional analysis of predicted metagenome suggests that trimethylamine-N-oxide biosynthesis pathway could be increased in the jejunal microbiota of T2D-meft group, while indole biosynthesis pathway could be increased in low HOMA-IR group. These results contribute to the increase in the scarce knowledge about the mucosal microbiota of the hardly accessible small intestine. (C) 2020 American Society for Bariatric Surgery. Published by Elsevier Inc. All rights reserved.
C1 [Gutierrez-Repiso, Carolina; Moreno-Indias, Isabel; Martin-Nunez, Gracia M.; Tinahones, Francisco J.] Univ Malaga, Unidad Gest Clin Endocrinol & Nutr, Hosp Virgen Victoria, Inst Invest Biomed Malaga, Madrid, Spain.
   [Gutierrez-Repiso, Carolina; Moreno-Indias, Isabel; Martin-Nunez, Gracia M.; Garcia-Fuentes, Eduardo; Tinahones, Francisco J.] CIBERobn, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Madrid, Spain.
   [Ho-Plagaro, Ailec] Univ Malaga, Unidad Gest Clin Aparato Digest, Inst Invest Biomed Malaga, Hosp Virgen Victoria, Malaga, Spain.
   [Rodriguez-Canete, Alberto] Hosp Reg Univ Malaga, Unidad Gest Clin Cirugia Gen Digest & Trasplantes, Malaga, Spain.
   [Rodriguez-Canete, Alberto] Univ Malaga, Dept Especialidades Quirurg Bioquim & Inmunol, Malaga, Spain.
   [Gonzalo, Monserrat] Hosp Reg Univ Malaga, Inst Invest Biomed Malaga, Unidad Gest Clin Endocrinol & Nutr, Malaga, Spain.
   [Garcia-Fuentes, Eduardo] Hosp Virgen Victoria, Inst Invest Biomed Malaga, Unidad Gest Clin Aparato Digest, Malaga, Spain.
C3 Universidad de Malaga; CIBER - Centro de Investigacion Biomedica en Red;
   CIBEROBN; Universidad de Malaga; Universidad de Malaga
RP Garcia-Fuentes, E (通讯作者)，Hosp Civil, Lab Invest, Plaza Hosp Civil S-N, Malaga 29010, Spain.; Tinahones, FJ (通讯作者)，Hosp Clin Univ Virgen Victoria, Unidad Gest Clin Endocrinol & Nutr, Campus Teatinos S-N, Malaga 29010, Spain.
EM edugf1@gmail.com; fjtina-hones@uma.es
RI Gutiérrez-Repiso, Carolina/F-8125-2010; Moreno-Indias,
   Isabel/B-6595-2017
OI Gutiérrez-Repiso, Carolina/0000-0002-5842-8873; Moreno-Indias,
   Isabel/0000-0002-6121-151X; Ho-Plagaro, Ailec/0000-0003-0135-2852;
   Tinahones, Francisco J/0000-0001-6871-4403
FU Ministerio de Economia, Industria y Competitividad ("Juan de la
   Cierva-Incorporacion") [IJCI-2017-33065]; "Miguel Servet type I" program
   [CP16/00163]; Ministerio de Economia, Industria y Competitividad (Juan
   de la Cierva-Formacion) [FJCI-2017-34349]; Ministerio de Educacion y
   Formacion Profesional [FPU14/01972]; Consejeria de Salud de la Junta de
   Andalucia [C-0031-2016, PI-0334-2016]; Instituto de Salud Carlos III
   [PI12/00338]; FEDER funds ("A way to make Europe")
FX CGR is supported by a grant from Ministerio de Economia, Industria y
   Competitividad ("Juan de la Cierva-Incorporacion" contract
   [IJCI-2017-33065]), IMI is supported by "Miguel Servet type I" program
   (CP16/00163), GMN is supported by a grant from Ministerio de Economia,
   Industria y Competitividad ("Juan de la Cierva-Formacion" contract
   [FJCI-2017-34349]), AHP is supported by a grant from the Ministerio de
   Educacion y Formacion Profesional (FPU14/01972), and EGF is supported by
   "Nicolas Monardes" program from the Consejeria de Salud de la Junta de
   Andalucia (C-0031-2016). This work was supported in part by a grant from
   Consejeria de Salud de la Junta de Andalucia (PI-0334-2016) and a grant
   from Instituto de Salud Carlos III (PI12/00338). This study has been
   co-funded by FEDER funds ("A way to make Europe").
CR Agus A, 2018, CELL HOST MICROBE, V23, P716, DOI 10.1016/j.chom.2018.05.003
   Alexeev EE, 2018, AM J PATHOL, V188, P1183, DOI 10.1016/j.ajpath.2018.01.011
   Angelakis E, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0137784
   Bansal T, 2010, P NATL ACAD SCI USA, V107, P228, DOI 10.1073/pnas.0906112107
   Burns MB, 2015, GENOME MED, V7, DOI 10.1186/s13073-015-0177-8
   Callahan BJ, 2016, NAT METHODS, V13, P581, DOI [10.1038/NMETH.3869, 10.1038/nmeth.3869]
   Carstens A, 2018, J DIGEST DIS, V19, P745, DOI 10.1111/1751-2980.12688
   Chung CS, 2016, SCAND J GASTROENTERO, V51, P410, DOI 10.3109/00365521.2015.1116107
   Dlugosz A, 2015, SCI REP-UK, V5, DOI 10.1038/srep08508
   Donaldson GP, 2016, NAT REV MICROBIOL, V14, P20, DOI 10.1038/nrmicro3552
   Dumas ME, 2017, CELL REP, V20, P136, DOI 10.1016/j.celrep.2017.06.039
   El Aidy S, 2015, CURR OPIN BIOTECH, V32, P14, DOI 10.1016/j.copbio.2014.09.005
   Faust K, 2012, PLOS COMPUT BIOL, V8, DOI 10.1371/journal.pcbi.1002606
   Galligan JJ, 2018, NEUROGASTROENT MOTIL, V30, DOI 10.1111/nmo.13283
   Gao J, 2018, FRONT CELL INFECT MI, V8, DOI 10.3389/fcimb.2018.00013
   Gao RY, 2018, OBESITY, V26, P351, DOI 10.1002/oby.22088
   Gibiino G, 2018, DIGEST LIVER DIS, V50, P635, DOI 10.1016/j.dld.2018.03.016
   Gribble FM, 2019, NAT REV ENDOCRINOL, V15, P226, DOI 10.1038/s41574-019-0168-8
   Gutierrez-Repiso C, 2015, LAB INVEST, V95, P1409, DOI 10.1038/labinvest.2015.115
   Hieken TJ, 2016, SCI REP-UK, V6, DOI 10.1038/srep30751
   Huo TG, 2009, J PHARMACEUT BIOMED, V49, P976, DOI 10.1016/j.jpba.2009.01.008
   Ialenti A, 2006, EUR J IMMUNOL, V36, P354, DOI 10.1002/eji.200535305
   Kasai C, 2015, BMC GASTROENTEROL, V15, DOI 10.1186/s12876-015-0330-2
   Katoh K, 2002, NUCLEIC ACIDS RES, V30, P3059, DOI 10.1093/nar/gkf436
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Le Chatelier E, 2013, NATURE, V500, P541, DOI 10.1038/nature12506
   Martin-Nunez GM, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0213548
   Mailhe M, 2018, BMC MICROBIOL, V18, DOI 10.1186/s12866-018-1304-7
   Moreno-Navarrete JM, 2018, MOL NUTR FOOD RES, V62, DOI 10.1002/mnfr.201700721
   Marsland BJ, 2016, NAT MED, V22, P581, DOI 10.1038/nm.4117
   McCreight LJ, 2016, DIABETOLOGIA, V59, P426, DOI 10.1007/s00125-015-3844-9
   Miao J, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms7498
   Moreno-Indias I, 2016, AM J TRANSL RES, V8, P5672
   Naderpoor N, 2019, J CLIN MED, V8, DOI 10.3390/jcm8040452
   Org E, 2017, GENOME BIOL, V18, DOI 10.1186/s13059-017-1194-2
   Parks DH, 2010, BIOINFORMATICS, V26, P715, DOI 10.1093/bioinformatics/btq041
   Price MN, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009490
   Raoult D, 2014, EUR J EPIDEMIOL, V29, P307, DOI 10.1007/s10654-014-9905-4
   RILHUB, 2020, RES INN LEARN HUB RI
   Scheithauer TPM, 2016, MOL METAB, V5, P759, DOI 10.1016/j.molmet.2016.06.002
   Seck EH, 2019, INT J OBESITY, V43, P862, DOI 10.1038/s41366-018-0201-3
   Seekatz AM, 2019, MSPHERE, V4, DOI 10.1128/mSphere.00126-19
   Seganfredo FB, 2017, OBES REV, V18, P832, DOI 10.1111/obr.12541
   Sepehri S, 2007, INFLAMM BOWEL DIS, V13, P675, DOI 10.1002/ibd.20101
   Shannon P, 2003, GENOME RES, V13, P2498, DOI 10.1101/gr.1239303
   Shi YC, 2019, GENOM PROTEOM BIOINF, V17, P52, DOI 10.1016/j.gpb.2018.12.004
   Soriguer F, 2010, J LIPID RES, V51, P3516, DOI 10.1194/jlr.M007815
   Stearns JC, 2011, SCI REP-UK, V1, DOI 10.1038/srep00170
   Turnbaugh PJ, 2009, NATURE, V457, P480, DOI 10.1038/nature07540
   Vrieze A, 2010, DIABETOLOGIA, V53, P606, DOI 10.1007/s00125-010-1662-7
   Walker AW, 2011, BMC MICROBIOL, V11, DOI 10.1186/1471-2180-11-7
   Wang M, 2005, FEMS MICROBIOL ECOL, V54, P219, DOI 10.1016/j.femsec.2005.03.012
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Zhou W, 2019, FRONT MICROBIOL, V10, DOI 10.3389/fmicb.2019.00232
NR 54
TC 6
Z9 6
U1 0
U2 6
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1550-7289
EI 1878-7533
J9 SURG OBES RELAT DIS
JI Surg. Obes. Relat. Dis.
PD OCT
PY 2020
VL 16
IS 10
BP 1575
EP 1585
DI 10.1016/j.soard.2020.04.008
PG 11
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA NY3SS
UT WOS:000576314300038
PM 32475753
DA 2023-06-08
ER

PT J
AU Lyu, YF
   Zhang, YF
   Yang, MB
   Lin, L
   Yang, X
   Cheung, SCK
   Shaw, PC
   Chan, PKS
   Kong, APS
   Zuo, Z
AF Lyu, Yuanfeng
   Zhang, Yufeng
   Yang, Mengbi
   Lin, Lin
   Yang, Xiao
   Cheung, Stanley Chun Kai
   Shaw, Pang Chui
   Chan, Paul Kay Sheung
   Kong, Alice Pik Shan
   Zuo, Zhong
TI Pharmacokinetic interactions between metformin and berberine in rats:
   Role of oral administration sequences and microbiota
SO LIFE SCIENCES
LA English
DT Article
DE Metformin; Berberine; Administration sequences; GI metabolism;
   Pharmacokinetics; Herb-drug interaction; Incubation
ID GUT MICROBIOTA; COMBINATION; EFFICACY; METABOLITES; MODULATION;
   TRANSPORT; THERAPY; ENZYMES; IMPACT; SAFETY
AB Aims: Considering the potential oral administration sequences and role of microbiota for metformin (MET) and berberine (BBR) during anti-diabetic treatments, the current study aimed to investigate the pharmacokinetic interactions between MET and BBR in rats after oral administration at different sequences and impacts of microbiota on such interactions.
   Main methods: Sprague-Dawley rats were divided into five groups as per what was orally administered to them: MET (G1)/BBR (G2) at 200 mg/kg, BBR 2-hour (h) after dosing MET (G3), MET 2-h after dosing BBR (G4) or MET with BBR at the same time (G5) followed by monitoring their pharmacokinetic profiles. Further in vitro incubations mimicking the above five treatments in rat intestinal content (G1R-G5R), human fecalase (G1H-G5H) and selected bacteria (G1B-G5B) were conducted for both MET and BBR (10 mu g/ml for G1R/H-G5R/H and 50 mu M for G1B-G5B) up to 24-h. Concentrations of MET and BBR were analyzed by LC/MS/MS.
   Key findings: Although BBR was barely measurable in vivo, it significantly increased systemic exposure of MET in G3/G4. Consistent with pharmacokinetic findings, sequential in vitro incubations of MET and BBR in both rat intestinal content and human fecalase demonstrated significant increase on MET persisted after 24-h incubation in G3R/H & G4R/H. Moreover, post-dose (G3B) and pre-dose (G4B) of BBR decreased the MET degradation significantly in most selected bacteria.
   Significance: Our finding for the first time demonstrated the significant effect of sequential co-administration of BBR and MET on their pharmacokinetic interactions, which could be related to their microbiota mediated metabolisms in gastrointestinal tract (GI).
C1 [Lyu, Yuanfeng; Zhang, Yufeng; Yang, Mengbi; Zuo, Zhong] Chinese Univ Hong Kong, Fac Med, Sch Pharm, Shatin, Hong Kong, Peoples R China.
   [Lin, Lin; Yang, Xiao; Chan, Paul Kay Sheung] Chinese Univ Hong Kong, Fac Med, Dept Microbiol, Shatin, Hong Kong, Peoples R China.
   [Cheung, Stanley Chun Kai; Shaw, Pang Chui] Chinese Univ Hong Kong, Sch Life Sci, Shatin, Hong Kong, Peoples R China.
   [Cheung, Stanley Chun Kai; Shaw, Pang Chui] Chinese Univ Hong Kong, Li Dak Sum Yip Yio Chin R&D Ctr Chinese Med, Shatin, Hong Kong, Peoples R China.
   [Kong, Alice Pik Shan] Chinese Univ Hong Kong, Dept Med & Therapeut, Div Endocrinol, Shatin, Hong Kong, Peoples R China.
C3 Chinese University of Hong Kong; Chinese University of Hong Kong;
   Chinese University of Hong Kong; Chinese University of Hong Kong;
   Chinese University of Hong Kong
RP Zuo, Z (通讯作者)，Chinese Univ Hong Kong, Fac Med, Sch Pharm, Shatin, Hong Kong, Peoples R China.
EM joanzuo@cuhk.edu.hk
RI Zuo, Zhong/B-6884-2008; Chan, Paul KS/J-9360-2013; Zhang,
   Yufeng/GZL-1973-2022; Cheung, Stanley Chun Kai CK/A-9302-2015; Yang,
   Xiao/P-8380-2016; zhang, yu/HNS-5948-2023; Kong, Alice/P-3703-2015
OI Chan, Paul KS/0000-0002-6360-4608; Kong, Alice/0000-0001-8927-6764;
   Yang, Xiao/0000-0002-3071-6531; Zuo, Zhong/0000-0002-6976-6157
FU Li Dak Sum Yip Yio Chin R&D Centre for Chinese Medicine at The Chinese
   University of Hong Kong
FX This work was partially supported by the Li Dak Sum Yip Yio Chin R&D
   Centre for Chinese Medicine at The Chinese University of Hong Kong.
CR Arhewoh MI, 2017, TROP J PHARM RES, V16, P1703, DOI 10.4314/tjpr.v16i7.31
   Benet LZ, 1999, J CONTROL RELEASE, V62, P25, DOI 10.1016/S0168-3659(99)00034-6
   Cao Y, 2016, ARCH IRAN MED, V19, P197, DOI 0161903/AIM.008
   Christensen MMH, 2011, PHARMACOGENET GENOM, V21, P837, DOI 10.1097/FPC.0b013e32834c0010
   Darvhekar V, 2016, CHIN J INTEGR MED, V22, P783, DOI 10.1007/s11655-016-2520-3
   Dou JT, 2018, DIABETES OBES METAB, V20, P590, DOI 10.1111/dom.13117
   Feng R, 2015, SCI REP-UK, V5, DOI 10.1038/srep12155
   Fong SYK, 2015, J ETHNOPHARMACOL, V170, P106, DOI 10.1016/j.jep.2015.04.036
   Franke AA, 2004, NUTR CANCER, V50, P141, DOI 10.1207/s15327914nc5002_3
   Gong L, 2012, PHARMACOGENET GENOM, V22, P820, DOI 10.1097/FPC.0b013e3283559b22
   Guo Y, 2012, EUR J CLIN PHARMACOL, V68, P213, DOI 10.1007/s00228-011-1108-2
   Hadjadj S, 2016, DIABETES CARE, V39, P1718, DOI 10.2337/dc16-0522
   Hardie DG, 2007, ANNU REV PHARMACOL, V47, P185, DOI 10.1146/annurev.pharmtox.47.120505.105304
   Heerspink HJL, 2017, J AM SOC NEPHROL, V28, P368, DOI 10.1681/ASN.2016030278
   Inzucchi SE, 2015, DIABETOLOGIA, V58, P429, DOI 10.1007/s00125-014-3460-0
   Jimmy EO, 2014, INT J INNOV MED HLTH, V2, P1
   Jin MJ, 2010, J TOXICOL ENV HEAL A, V73, P1441, DOI 10.1080/15287394.2010.511549
   Kokare V, 2015, INT J PHARM SCI RES, V6, P2056, DOI 10.13040/IJPSR.0975-8232.6(5).2056-65
   Kwon M, 2015, ARCH PHARM RES, V38, P849, DOI 10.1007/s12272-014-0510-6
   Lee H, 2018, GERONTOLOGIST, V58, P159, DOI 10.1093/geront/gnx050
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Li DY, 2017, SCI REP-UK, V7, DOI 10.1038/srep45840
   Lian FM, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0130550
   Liang XM, 2017, J PHARM SCI-US, V106, P2245, DOI 10.1016/j.xphs.2017.04.078
   Liu Y., 2010, NEW FINANCE, V10, P38
   Ma JY, 2013, J PHARM SCI-US, V102, P4181, DOI 10.1002/jps.23718
   Ma RCW, 2018, J DIABETES INVEST, V9, P579, DOI 10.1111/jdi.12746
   Machavaram Krishna K., 2006, Drug Metabolism and Drug Interactions, V22, P47
   Maeng HJ, 2002, J PHARM SCI, V91, P2614, DOI 10.1002/jps.10268
   Maier L, 2018, NATURE, V555, P623, DOI 10.1038/nature25979
   Methaneethorn J, 2014, IEEE ENG MED BIO, P5703, DOI 10.1109/EMBC.2014.6944922
   Moghaddam HK, 2014, MOL NEUROBIOL, V49, P820, DOI 10.1007/s12035-013-8559-7
   Quan HB, 2017, EXP THER MED, V14, P3279, DOI 10.3892/etm.2017.4863
   Shi R, 2019, EUR J PHARM SCI, V127, P282, DOI 10.1016/j.ejps.2018.11.010
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   SIRTORI CR, 1978, CLIN PHARMACOL THER, V24, P683
   Stein SA, 2013, EXPERT OPIN DRUG SAF, V12, P153, DOI 10.1517/14740338.2013.752813
   STRONG HA, 1987, XENOBIOTICA, V17, P685, DOI 10.3109/00498258709043976
   Tang J, 2009, J ETHNOPHARMACOL, V126, P5, DOI 10.1016/j.jep.2009.08.009
   Tian P, 2013, MOL VIS, V19, P2092
   Tovchiga OV, 2016, BMC COMPLEM ALTERN M, V16, DOI 10.1186/s12906-016-1221-y
   TUCKER GT, 1981, BRIT J CLIN PHARMACO, V12, P235
   US FDA, 2018, GUID IND BIOAN METH
   Waisundara VY, 2008, AM J CHINESE MED, V36, P517, DOI 10.1142/S0192415X08005953
   Waisundara VY, 2011, LIFE SCI, V88, P1016, DOI 10.1016/j.lfs.2011.03.009
   Waisundara VY, 2009, J AGR FOOD CHEM, V57, P4096, DOI 10.1021/jf8028539
   Waisundara VY, 2008, AM J CHINESE MED, V36, P1083, DOI 10.1142/S0192415X08006594
   Wang Y, 2017, METABOLISM, V70, P72, DOI 10.1016/j.metabol.2017.02.003
   Wong JMW, 2006, J CLIN GASTROENTEROL, V40, P235, DOI 10.1097/00004836-200603000-00015
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Xu JH, 2017, MOL MED REP, V15, P2765, DOI 10.3892/mmr.2017.6321
   Yin J, 2008, METABOLISM, V57, P712, DOI 10.1016/j.metabol.2008.01.013
   Yoo HH, 2016, J HYPERTENS, V34, P156, DOI 10.1097/HJH.0000000000000773
   Zhang X, 2012, PLOS ONE, V7, DOI [10.1371/journal.pone.0040320, 10.1371/journal.pone.0042529]
   Zhang XQ, 2015, SCI REP-UK, V5, DOI 10.1038/srep10737
   Zhang Y, 2013, INT J BIOL MACROMOL, V59, P363, DOI 10.1016/j.ijbiomac.2013.04.074
   Zhang Y, 2016, EVID-BASED COMPL ALT, V2016, DOI 10.1155/2016/1592731
NR 57
TC 9
Z9 9
U1 1
U2 21
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD OCT 15
PY 2019
VL 235
AR 116818
DI 10.1016/j.lfs.2019.116818
PG 9
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA JG8RS
UT WOS:000492345900015
PM 31473193
DA 2023-06-08
ER

PT J
AU Li, M
   Li, XY
   Zhang, HJ
   Lu, Y
AF Li, Min
   Li, Xiaoying
   Zhang, Huijie
   Lu, Yan
TI Molecular Mechanisms of Metformin for Diabetes and Cancer Treatment
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Review
DE metformin; type 2 diabetes; gluconeogenesis; hepatic glucose production;
   cancer; cell proliferation; AMPK; mTOR
ID ACTIVATED PROTEIN-KINASE; INHIBITS HEPATIC GLUCONEOGENESIS;
   GLUCOSE-PRODUCTION; AMPK; GROWTH; LIVER; PHOSPHORYLATION; METABOLISM;
   DICER; CHEMOTHERAPY
AB Metformin has been the first-line drug treatment for hyperglycemia and insulin resistance for over 50 years. However, the molecular basis of its therapeutic role remained incompletely understood. Recent advances demonstrate that metformin could exert its glucose-lowering effect by multiple mechanisms, including activation of 5 0-AMP-activated protein kinase, decreasing production of cyclic AMP, suppressing mitochondrial complex I of the electron transport chain, targeting glycerophosphate dehydrogenase, and altering the gut microbiome. In addition, epidemiological and clinical observation studies suggest that metformin reduced cancer risk in patients with type 2 diabetes and improved survival outcome of human cancers. Experimental studies have shown that this drug can inhibit cancer cell viability, growth, and proliferation through inhibiting mTORC1 signaling and mitochondrial complex I, suggesting that it may be a promising drug candidate for malignancy. Here, we summarize recent progress in studies of metformin in type 2 diabetes and tumorigenesis, which provides novel insight on the therapeutic development of human diseases.
C1 [Li, Min; Li, Xiaoying; Zhang, Huijie; Lu, Yan] Fudan Univ, Zhongshan Hosp, Dept Endocrinol & Metab, Shanghai, Peoples R China.
   [Zhang, Huijie] Southern Med Univ, Nanfang Hosp, Dept Endocrinol & Metab, Guangzhou, Guangdong, Peoples R China.
C3 Fudan University; Southern Medical University - China
RP Zhang, HJ; Lu, Y (通讯作者)，Fudan Univ, Zhongshan Hosp, Dept Endocrinol & Metab, Shanghai, Peoples R China.; Zhang, HJ (通讯作者)，Southern Med Univ, Nanfang Hosp, Dept Endocrinol & Metab, Guangzhou, Guangdong, Peoples R China.
EM huijiezhang2005@126.com; rjluyan@126.com
RI ZHANG, hui jie/HTN-1690-2023; liang, liang/IAO-8518-2023; Zhang,
   Hw/HPD-4999-2023; Zhang, Hui/HHN-8494-2022; zhang, hui/GXH-6098-2022
OI Li, Xiaoying/0000-0002-9383-5757
FU Natural Science Foundation of China [81570769, 81570785]; Shanghai
   Rising-Star Program by Science and Technology Commission of Shanghai
   Municipality [17QA1400800]; Shanghai Education Development Foundation
   [15CG11]; Shanghai Municipal Education Commission [15CG11]
FX This study was supported by grants from Natural Science Foundation of
   China (Nos. 81570769 and 81570785), Shanghai Rising-Star Program by
   Science and Technology Commission of Shanghai Municipality
   (17QA1400800), and Chenguang Program supported by Shanghai Education
   Development Foundation and Shanghai Municipal Education Commission
   (15CG11).
CR Amer Diabet Assoc, 2014, DIABETES CARE, V37, pS14, DOI 10.2337/dc14-S014
   Bailey CJ, 2008, DIABETOLOGIA, V51, P1552, DOI 10.1007/s00125-008-1053-5
   BAILEY CJ, 1989, DIABETES CARE, V12, P553, DOI 10.2337/diacare.12.8.553
   Batandier C, 2006, J BIOENERG BIOMEMBR, V38, P33, DOI 10.1007/s10863-006-9003-8
   Bauer PV, 2018, CELL METAB, V27, P101, DOI 10.1016/j.cmet.2017.09.019
   Ben Sahra I, 2011, CANCER RES, V71, P4366, DOI 10.1158/0008-5472.CAN-10-1769
   Blandino G, 2012, NAT COMMUN, V3, DOI 10.1038/ncomms1859
   Boudaba N, 2018, EBIOMEDICINE, V28, P194, DOI 10.1016/j.ebiom.2018.01.008
   Candido Saverio, 2018, Advances in Biological Regulation, V68, P13, DOI 10.1016/j.jbior.2018.02.002
   Cao J, 2014, J BIOL CHEM, V289, P20435, DOI 10.1074/jbc.M114.567271
   Cokorinos EC, 2017, CELL METAB, V25, P1147, DOI 10.1016/j.cmet.2017.04.010
   DILMAN VM, 1978, ARCH GESCHWULSTFORSC, V48, P1
   DILMAN VM, 1982, ONCOLOGY-BASEL, V39, P13, DOI 10.1159/000225596
   Dowling RJO, 2007, CANCER RES, V67, P10804, DOI 10.1158/0008-5472.CAN-07-2310
   Duca FA, 2015, NAT MED, V21, P506, DOI 10.1038/nm.3787
   Evans JMM, 2005, BMJ-BRIT MED J, V330, P1304, DOI 10.1136/bmj.38415.708634.F7
   Ford RJ, 2015, BIOCHEM J, V468, P125, DOI 10.1042/BJ20150125
   Foretz M, 2010, J CLIN INVEST, V120, P2355, DOI 10.1172/JCI40671
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Franciosi M, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0071583
   Fullerton MD, 2013, NAT MED, V19, P1649, DOI 10.1038/nm.3372
   Garg SK, 2014, DIABETES OBES METAB, V16, P97, DOI 10.1111/dom.12124
   Gui DY, 2016, CELL METAB, V24, P716, DOI 10.1016/j.cmet.2016.09.006
   Gwinn DM, 2008, MOL CELL, V30, P214, DOI 10.1016/j.molcel.2008.03.003
   Hadad S, 2011, BREAST CANCER RES TR, V128, P783, DOI 10.1007/s10549-011-1612-1
   Hadad SM, 2015, BREAST CANCER RES TR, V150, P149, DOI 10.1007/s10549-015-3307-5
   Hardie DG, 2012, NAT REV MOL CELL BIO, V13, P251, DOI 10.1038/nrm3311
   He GF, 2014, MOL CELL BIOL, V34, P148, DOI 10.1128/MCB.00670-13
   He JJ, 2015, SCI REP-UK, V5, DOI 10.1038/srep17423
   He L, 2015, CELL METAB, V21, P159, DOI 10.1016/j.cmet.2015.01.003
   He L, 2009, CELL, V137, P635, DOI 10.1016/j.cell.2009.03.016
   Hirsch HA, 2013, P NATL ACAD SCI USA, V110, P972, DOI 10.1073/pnas.1221055110
   Hosono K, 2010, CANCER PREV RES, V3, P1077, DOI 10.1158/1940-6207.CAPR-10-0186
   Hou GF, 2013, BREAST CANCER RES TR, V137, P807, DOI 10.1007/s10549-012-2404-y
   Howell JJ, 2017, CELL METAB, V25, P463, DOI 10.1016/j.cmet.2016.12.009
   Huai L, 2012, BIOCHEM BIOPH RES CO, V422, P398, DOI 10.1016/j.bbrc.2012.05.001
   Iliopoulos D, 2011, CANCER RES, V71, P3196, DOI 10.1158/0008-5472.CAN-10-3471
   Inoki K, 2003, CELL, V115, P577, DOI 10.1016/S0092-8674(03)00929-2
   Inzucchi SE, 1998, NEW ENGL J MED, V338, P867, DOI 10.1056/NEJM199803263381303
   Jensen JB, 2016, DIABETES, V65, P1724, DOI 10.2337/db16-0032
   Jiralerspong S, 2009, J CLIN ONCOL, V27, P3297, DOI 10.1200/JCO.2009.19.6410
   Jones RG, 2005, MOL CELL, V18, P283, DOI 10.1016/j.molcel.2005.03.027
   Kalender A, 2010, CELL METAB, V11, P390, DOI 10.1016/j.cmet.2010.03.014
   Kalogirou C, 2016, UROL INT, V96, P106, DOI 10.1159/000441011
   Karube Y, 2005, CANCER SCI, V96, P111, DOI 10.1111/j.1349-7006.2005.00015.x
   Kim YD, 2008, DIABETES, V57, P306, DOI 10.2337/db07-0381
   Kordes S, 2015, LANCET ONCOL, V16, P839, DOI 10.1016/S1470-2045(15)00027-3
   Laplante M, 2012, CELL, V149, P274, DOI 10.1016/j.cell.2012.03.017
   Li ZH, 2018, ONCOL LETT, V15, P7948, DOI 10.3892/ol.2018.8297
   Lin SC, 2018, CELL METAB, V27, P299, DOI 10.1016/j.cmet.2017.10.009
   Liu XJ, 2016, CELL METAB, V24, P728, DOI 10.1016/j.cmet.2016.09.005
   LUFT D, 1978, DIABETOLOGIA, V14, P75, DOI 10.1007/BF01263444
   Madiraju AK, 2014, NATURE, V510, P542, DOI 10.1038/nature13270
   Mamtani R, 2014, DIABETES CARE, V37, P1910, DOI 10.2337/dc13-1489
   Martello G, 2010, CELL, V141, P1195, DOI 10.1016/j.cell.2010.05.017
   Meng SM, 2015, J BIOL CHEM, V290, P3793, DOI 10.1074/jbc.M114.604421
   Merritt WM, 2008, NEW ENGL J MED, V359, P2641, DOI 10.1056/NEJMoa0803785
   Miller RA, 2013, NATURE, V494, P256, DOI 10.1038/nature11808
   Miranda VC, 2014, DRUG TODAY, V50, P623, DOI 10.1358/dot.2014.50.9.2229920
   Morales DR, 2015, ANNU REV MED, V66, P17, DOI 10.1146/annurev-med-062613-093128
   Paleari L, 2018, GASTROENTEROLOGY, V154, P1543, DOI 10.1053/j.gastro.2017.12.040
   Pernicova I, 2014, NAT REV ENDOCRINOL, V10, P143, DOI 10.1038/nrendo.2013.256
   Pollak MN, 2012, CANCER DISCOV, V2, P778, DOI 10.1158/2159-8290.CD-12-0263
   Pulito C, 2014, ANN TRANSL MED, V2, DOI 10.3978/j.issn.2305-5839.2014.06.03
   Rena G, 2017, DIABETOLOGIA, V60, P1577, DOI 10.1007/s00125-017-4342-z
   Rines AK, 2016, NAT REV DRUG DISCOV, V15, P786, DOI 10.1038/nrd.2016.151
   Saxton RA, 2017, CELL, V168, P960, DOI [10.1016/j.cell.2017.02.004, 10.1016/j.cell.2017.03.035]
   Shaw RJ, 2005, SCIENCE, V310, P1642, DOI 10.1126/science.1120781
   Suissa S, 2014, DIABETES CARE, V37, P1786, DOI 10.2337/dc14-0500
   Viollet B, 2012, CLIN SCI, V122, P253, DOI 10.1042/CS20110386
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Wu LF, 2016, CELL, V167, P1705, DOI 10.1016/j.cell.2016.11.055
   Xu T, 2015, DIABETES CARE, V38, P1858, DOI 10.2337/dc15-0658
   Yi Y, 2017, J CANCER, V8, P2636, DOI 10.7150/jca.19873
   Zakikhani M, 2006, CANCER RES, V66, P10269, DOI 10.1158/0008-5472.CAN-06-1500
   Zhang CS, 2016, CELL METAB, V24, P521, DOI 10.1016/j.cmet.2016.09.003
   Zhang PP, 2013, CANCER EPIDEMIOL, V37, P207, DOI 10.1016/j.canep.2012.12.009
   Zhang YF, 2014, DIABETES CARE, V37, P2804, DOI 10.2337/dc14-0090
   Zhou GC, 2001, J CLIN INVEST, V108, P1167, DOI 10.1172/JCI200113505
   Zhou JY, 2015, DRUG DEVELOP RES, V76, P263, DOI 10.1002/ddr.21265
NR 80
TC 58
Z9 62
U1 4
U2 35
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD JUL 31
PY 2018
VL 9
AR 1039
DI 10.3389/fphys.2018.01039
PG 7
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA GO8QV
UT WOS:000440358800002
PM 30108523
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Pastor-Villaescusa, B
   Plaza-Diaz, J
   Egea-Zorrilla, A
   Leis, R
   Bueno, G
   Hoyos, R
   Vazquez-Cobela, R
   Latorre, M
   Canete, MD
   Caballero-Villarraso, J
   Gil, A
   Canete, R
   Aguilera, CM
AF Pastor-Villaescusa, Belen
   Plaza-Diaz, Julio
   Egea-Zorrilla, Alejandro
   Leis, Rosaura
   Bueno, Gloria
   Hoyos, Raul
   Vazquez-Cobela, Rocio
   Latorre, Miriam
   Dolores Canete, Maria
   Caballero-Villarraso, Javier
   Gil, Angel
   Canete, Ramon
   Maria Aguilera, Concepcion
TI Evaluation of the gut microbiota after metformin intervention in
   children with obesity: A metagenomic study of a randomized controlled
   trial
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Metformin; Microbiota; Children population; Pubertal stage; Obesity
ID DIABETES-MELLITUS; OVERWEIGHT; CHILDHOOD; AGE
AB Background: Metformin, a first-line oral antidiabetic agent that has shown promising results in terms of treating childhood and adolescent obesity, might influence the composition of the gut microbiota. We aimed to evaluate whether the gut microbiota of non-diabetic children with obesity changes after a metformin intervention.
   Methods: The study was a multicenter and double-blind randomized controlled trial in 160 children with obesity. Children were randomly assigned to receive either metformin (1 g/day) or placebo for 6 months in combination with healthy lifestyle recommendations in both groups. Then, we conducted a metagenomic analysis in a sub-sample obtained from 33 children (15 metformin, 18 placebo). A linear mixed-effects model (LMM) was used to determine the abundance changes from baseline to six months according to treatment. To analyze the data by clusters, a principal component analysis was performed to understand whether lifestyle habits have a different influence on the microbiota depending on the treatment group.
   Results: Actinobacteria abundance was higher after placebo treatment compared with metformin. However, the interaction time x treatment just showed a trend to be significant (4.6% to 8.1% after placebo vs. 3.8 % to 2.6 % after metformin treatment, p = 0.055). At genus level, only the abundance of Bacillus was significantly higher after the placebo intervention compared with metformin (2.5% to 5.7% after placebo vs. 1.5 % to 0.8 % after metformin treatment, p = 0.044). Furthermore, different ensembles formed by Firmicutes, Bacteroidetes, and Verrucomicrobia were found according to the interventions under a similar food consumption.
   Conclusion: Further studies with a large sample size controlled by lifestyle patterns are required in obese children and adolescents to clarify whether metformin might trigger gut microbiota alterations.
C1 [Pastor-Villaescusa, Belen] Tech Univ Munich, Else Kroner Fresenius Ctr Nutr Med, Sch Life Sci, Inst Nutr Med, D-85354 Freising Weihenstephan, Germany.
   [Pastor-Villaescusa, Belen; Plaza-Diaz, Julio; Gil, Angel; Maria Aguilera, Concepcion] Univ Granada, Sch Pharm, Dept Biochem & Mol Biol 2, Granada 18071, Spain.
   [Pastor-Villaescusa, Belen; Plaza-Diaz, Julio; Egea-Zorrilla, Alejandro; Gil, Angel; Maria Aguilera, Concepcion] Univ Granada, Ctr Biomed Res, Inst Nutr & Food Technol Jose Mataix, Avda Conocimiento S-N, Granada 18016, Spain.
   [Plaza-Diaz, Julio; Gil, Angel; Maria Aguilera, Concepcion] Complejo Hosp Univ Granada, Inst Invest Biosanitaria IBS GRANADA, Granada 18014, Spain.
   [Leis, Rosaura; Bueno, Gloria; Gil, Angel; Maria Aguilera, Concepcion] Inst Salud Carlos III, CIBEROBN CIBER Physiopathol Obes & Nutr, Madrid 28029, Spain.
   [Leis, Rosaura; Vazquez-Cobela, Rocio] Univ Santiago de Compostela, Clin Univ Hosp Santiago, Paediat Dept, Unit Invest Nutr Growth & Human Dev Galicia, Santiago De Compostela 15706, Spain.
   [Bueno, Gloria; Latorre, Miriam] Univ Zaragoza, Lozano Blesa Univ Clin Hosp, Pediat Dept, Zaragoza 50009, Spain.
   [Hoyos, Raul] Virgen de Las Nieves Univ Hosp, Pediat Dept, Andalusian Hlth Serv, Granada 18014, Spain.
   [Latorre, Miriam] Pediat Dept, Zaragoza 50009, Spain.
   [Latorre, Miriam] Hlth Sci Inst Aragon, Zaragoza 50009, Spain.
   [Dolores Canete, Maria; Canete, Ramon] Maimonides Inst Biomed Res Cordoba IMIBIC, PAIDI CTS 329, Cordoba 14004, Spain.
   [Caballero-Villarraso, Javier] Cordoba Univ, IMIBIC Reina Sofia Hosp, Clin Anal Serv, Cordoba 14004, Spain.
   [Canete, Ramon] Reina Sofia Univ Hosp, Unit Paediat Endocrinol, Cordoba 14004, Spain.
C3 Technical University of Munich; University of Granada; University of
   Granada; Instituto de Investigacion Biosanitaria IBS Granada; University
   of Granada; Instituto de Salud Carlos III; Complexo Hospitalario
   Universitario de Santiago de Compostela; Universidade de Santiago de
   Compostela; Lozano Blesa University Clinical Hospital; University of
   Zaragoza; Hospital Universitario Virgen de las Nieves; Hospital
   Universitario Reina Sofia - Cordoba
RP Pastor-Villaescusa, B; Plaza-Diaz, J (通讯作者)，Univ Granada, Sch Pharm, Dept Biochem & Mol Biol 2, Granada 18071, Spain.
EM belen.pastor@tum.de; jrplaza@ugr.es
RI Pastor-Villaescusa, Belén/GRF-0832-2022; Plaza-Diaz, Julio/C-8094-2016;
   Bueno-Lozano, Gloria/AAK-7748-2021; Caballero-Villarraso,
   Javier/AAC-3434-2019; Villaescusa, Maria Belen Pastor/ABA-2162-2021;
   Aguilera, Concepcion/M-1663-2014
OI Plaza-Diaz, Julio/0000-0002-5171-9408; Caballero-Villarraso,
   Javier/0000-0003-0571-5147; Villaescusa, Maria Belen
   Pastor/0000-0003-0817-6804; Egea Zorrilla,
   Alejandro/0000-0002-5522-8227; CANETE, MD/0000-0002-8296-1846;
   Latorre-Millan, Miriam/0000-0001-9932-0124; Aguilera,
   Concepcion/0000-0002-1451-4788
FU Spanish Ministry of Health, Social and Equality, General Department for
   Pharmacy and Health Products; Instituto de Salud Carlos III-Fondo de
   Investigacion Sanitaria (FONDOS FEDER), Redes tematicas de investigacion
   cooperativa RETIC [Red SAMID RD12/0026/0015]
FX In Acknowledgments, the authors have mentioned the public funding that
   this project received: The authors acknowledge the Spanish Ministry of
   Health, Social and Equality, General Department for Pharmacy and Health
   Products for financing this study and the Instituto de Salud Carlos
   III-Fondo de Investigacion Sanitaria (FONDOS FEDER), Redes tematicas de
   investigacion cooperativa RETIC (Red SAMID RD12/0026/0015).
CR Afshin A, 2017, NEW ENGL J MED, V377, P13, DOI 10.1056/NEJMoa1614362
   Aranceta-Bartrina J, 2019, NUTRIENTS, V11, DOI 10.3390/nu11112675
   Arora T, 2016, J INTERN MED, V280, P339, DOI 10.1111/joim.12508
   Bailey CJ, 2008, DIABETOLOGIA, V51, P1552, DOI 10.1007/s00125-008-1053-5
   Brahe LK, 2015, NUTR DIABETES, V5, DOI 10.1038/nutd.2015.9
   Bryrup T, 2019, DIABETOLOGIA, V62, P1024, DOI 10.1007/s00125-019-4848-7
   Cole TJ, 2000, BMJ-BRIT MED J, V320, P1240, DOI 10.1136/bmj.320.7244.1240
   Cornejo-Pareja I, 2019, EUR J CLIN NUTR, V72, P26, DOI 10.1038/s41430-018-0306-8
   Dao MC, 2016, GUT, V65, P426, DOI 10.1136/gutjnl-2014-308778
   David CC, 2014, METHODS MOL BIOL, V1084, P193, DOI 10.1007/978-1-62703-658-0_11
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Duca FA, 2015, NAT MED, V21, P506, DOI 10.1038/nm.3787
   Ejtahed HS, 2019, EUR J ENDOCRINOL, V180, P165, DOI [10.1530/EJE-18-0826, 10.1530/eje-18-0826]
   Ejtahed HS, 2017, ALTERN THER HEALTH M, V23, P8
   Finlayson A, 2015, WORLD J GASTRO ENDOS, V7, P1103, DOI [10.4253/wjge.v7.i13.1103, 10.4291/wjgp.v6.i4.110]
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Garcia-Albiach R., 2008, MOL ANAL YOGURT CONT, P1
   Kelly AS, 2016, INT J OBESITY, V40, P1043, DOI 10.1038/ijo.2016.69
   Lee H, 2018, GUT MICROBES, V9, P155, DOI 10.1080/19490976.2017.1405209
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Ley RE, 2005, P NATL ACAD SCI USA, V102, P11070, DOI 10.1073/pnas.0504978102
   Li QZ, 2020, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00939
   Ma W, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.01336
   Manios Y, 2015, J HUM NUTR DIET, V28, P50, DOI 10.1111/jhn.12183
   Mardinoglu A, 2016, CELL METAB, V23, P10, DOI 10.1016/j.cmet.2015.12.012
   McCreight LJ, 2016, DIABETOLOGIA, V59, P426, DOI 10.1007/s00125-015-3844-9
   Mead E, 2016, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD012436
   Monira S, 2011, FRONT MICROBIOL, V2, DOI 10.3389/fmicb.2011.00228
   Mueller S, 2006, APPL ENVIRON MICROB, V72, P1027, DOI 10.1128/AEM.72.2.1027-1033.2006
   Pascale A, 2019, CURR OPIN PHARMACOL, V49, P1, DOI 10.1016/j.coph.2019.03.011
   Pastor-Villaescusa B, 2017, PEDIATRICS, V140, DOI [10.1542/peds.2017-1205, 10.1542/peds.2016-4285]
   Pastor-Villaescusa B, 2016, TRIALS, V17, DOI 10.1186/s13063-016-1403-4
   Peters BA, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-28126-1
   Plaza-Diaz J, 2019, NUTRIENTS, V11, DOI 10.3390/nu11020337
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Rotroff DM, 2016, FRONT PHARMACOL, V7, DOI 10.3389/fphar.2016.00135
   Sanchez M, 2015, INT J ENV RES PUB HE, V12, P162, DOI 10.3390/ijerph120100162
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Smith-Brown P, 2016, SCI REP-UK, V6, DOI 10.1038/srep32385
   Sohail Muhammad U, 2019, Rev Diabet Stud, V15, P35, DOI 10.1900/RDS.2019.15.35
   Sroka-Oleksiak A, 2020, J CLIN MED, V9, DOI 10.3390/jcm9020369
   TANNER JM, 1976, ARCH DIS CHILD, V51, P170, DOI 10.1136/adc.51.3.170
   Tong XL, 2018, MBIO, V9, DOI 10.1128/mBio.02392-17
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Vael C, 2011, GUT PATHOG, V3, DOI 10.1186/1757-4749-3-8
   Vyncke K, 2013, BRIT J NUTR, V109, P2067, DOI 10.1017/S000711451200414X
   Warnakulasuriya LS, 2018, CHILD OBES, V14, P553, DOI 10.1089/chi.2018.0043
   Whitaker RC, 1997, NEW ENGL J MED, V337, P869, DOI 10.1056/NEJM199709253371301
   Wu B, 2019, LIFE SCI, V226, P185, DOI 10.1016/j.lfs.2019.04.009
   Xiang L, 2020, AGING-US, V12, P13991, DOI 10.18632/aging.103521
   Yassour M, 2016, GENOME MED, V8, DOI 10.1186/s13073-016-0271-6
   Yatsunenko T, 2012, NATURE, V486, P222, DOI 10.1038/nature11053
   Zhang XY, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0071108
NR 53
TC 7
Z9 7
U1 0
U2 11
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD FEB
PY 2021
VL 134
AR 111117
DI 10.1016/j.biopha.2020.111117
PG 8
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA PY7MI
UT WOS:000612225800006
PM 33360047
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Ursini, F
   Russo, E
   Pellino, G
   D'Angelo, S
   Chiaravalloti, A
   De Sarro, G
   Manfredini, R
   De Giorgio, R
AF Ursini, Francesco
   Russo, Emilio
   Pellino, Gianluca
   D'Angelo, Salvatore
   Chiaravalloti, Agostino
   De Sarro, Giovambattista
   Manfredini, Roberto
   De Giorgio, Roberto
TI Metformin and Autoimmunity: A "New Deal" of an Old Drug
SO FRONTIERS IN IMMUNOLOGY
LA English
DT Review
DE metformin; autoimmunity; autoimmune diseases; T cell; B cell;
   macrophage; neutrophil; fibroblast
ID MIGRATION INHIBITORY FACTOR; TO-LYMPHOCYTE RATIO; B-CELL SUBSETS;
   MAMMALIAN TARGET; TREATED PATIENTS; DISEASE-ACTIVITY; GUT MICROBIOTA; C.
   ELEGANS; TH17 CELLS; FACTOR MIF
AB Metformin (dimethyl biguanide) is a synthetic derivative of guanidine, isolated from the extracts of Galega officinalis, a plant with a prominent antidiabetic effect. Since its discovery more than 50 years ago, metformin represents a worldwide milestone in treatment of patients with type 2 diabetes (T2D). Recent evidence in humans indicates novel pleiotropic actions of metformin which span from its consolidated role in T2D management up to various regulatory properties, including cardio-and nephro-protection, as well as antiproliferative, antifibrotic, and antioxidant effects. These findings, together with ground-breaking studies demonstrating its ability to prolong healthspan and lifespan in mice, provided the basis for defining metformin as a potential antiaging molecule. Moreover, emerging in vivo and in vitro evidence support the novel hypothesis that metformin can exhibit immune-modulatory features. Studies suggest that metformin interferes with key immunopathological mechanisms involved in systemic autoimmune diseases, such as the T helper 17/regulatory T cell balance, germinal centers formation, autoantibodies production, macrophage polarization, cytokine synthesis, neutrophil extracellular traps release, and bone or extracellular matrix remodeling. These effects may represent a powerful contributor to antiaging and anticancer properties exerted by metformin and, from another standpoint, may open the way to assess whether metformin can be a candidate molecule for clinical trials involving patients with immune-mediated diseases. In this article, we will review the available preclinical and clinical evidence regarding the effect of metformin on individual cells of the immune system, with emphasis on immunological mechanisms related to the development and maintenance of autoimmunity and its potential relevance in treatment of autoimmune diseases.
C1 [Ursini, Francesco; Russo, Emilio; De Sarro, Giovambattista] Univ Catanzaro Magna Graecia, Dept Hlth Sci, Catanzaro, Italy.
   [Pellino, Gianluca] Hosp Univ & Politecn La Fe, Colorectal Unit, Valencia, Spain.
   [Pellino, Gianluca] Univ Campania Luigi Vanvitelli, Dept Med Surg Neurol Metab & Ageing Sci, Naples, Italy.
   [D'Angelo, Salvatore] San Carlo Hosp Potenza, Rheumatol Dept Lucania, Rheumatol Inst Lucania IReL, Potenza, Italy.
   [D'Angelo, Salvatore] Madonna Grazie Hosp Matera, Potenza, Italy.
   [D'Angelo, Salvatore] Basilicata Ric Biomed BRB Fdn, Potenza, Italy.
   [Chiaravalloti, Agostino] Univ Tor Vergata, Dept Biomed & Prevent, Rome, Italy.
   [Chiaravalloti, Agostino] IRCCS Neuromed, Dept Nucl Med, Pozzilli, Italy.
   [Manfredini, Roberto; De Giorgio, Roberto] Univ Ferrara, Dept Med Sci, Clin Med Unit, Ferrara, Italy.
C3 Magna Graecia University of Catanzaro; Hospital Universitari i
   Politecnic La Fe; Universita della Campania Vanvitelli; University of
   Rome Tor Vergata; IRCCS Neuromed; University of Ferrara
RP Ursini, F (通讯作者)，Univ Catanzaro Magna Graecia, Dept Hlth Sci, Catanzaro, Italy.
EM francesco.ursini@yahoo.it
RI Manfredini, Roberto/AAJ-5442-2020; Manfredini, Roberto/N-3859-2019;
   Chiaravalloti, Agostino/AAA-3342-2021; Russo, Emilio/G-5241-2010;
   Chiaravalloti, Agostino/HLW-1661-2023; De Giorgio,
   Roberto/GSD-7139-2022; Manfredini, Roberto/A-3471-2008; D'Angelo,
   Salvatore/H-9010-2012; Ursini, Francesco/AAC-5725-2022; Ursini,
   Francesco/K-5632-2016
OI Manfredini, Roberto/0000-0002-8364-2601; Chiaravalloti,
   Agostino/0000-0002-8017-8858; Russo, Emilio/0000-0002-1279-8123; De
   Giorgio, Roberto/0000-0003-0867-5873; Manfredini,
   Roberto/0000-0002-8364-2601; D'Angelo, Salvatore/0000-0002-7442-1110;
   Ursini, Francesco/0000-0001-8194-8642; Pellino,
   Gianluca/0000-0002-8322-6421
FU Fondi Ateneo Ricerca (FAR)
FX This work was supported by Fondi Ateneo Ricerca (FAR) 2014-Prof. R.
   Manfredini.
CR Alkhatib Y, 2017, LEUKEMIA LYMPHOMA, V58, P1130, DOI 10.1080/10428194.2016.1239822
   Anabtawi A, 2016, ENDOCR PRACT, V22, P999, DOI 10.4158/EP151145.RA
   Argyriou Pinelopi, 2012, Adv Hematol, V2012, P435342, DOI 10.1155/2012/435342
   Bai J, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0072120
   Bailey C, 2004, PRACT DIAB INT, V21, P115, DOI [DOI 10.1002/PDI.606, 10.1002/pdi.606]
   Barzilai N, 2016, CELL METAB, V23, P1060, DOI 10.1016/j.cmet.2016.05.011
   Bauer PV, 2018, CELL METAB, V27, P101, DOI 10.1016/j.cmet.2017.09.019
   Baugh JA, 2002, GENES IMMUN, V3, P170, DOI 10.1038/sj.gene.6363867
   Ben Sahra I, 2011, CANCER RES, V71, P4366, DOI 10.1158/0008-5472.CAN-10-1769
   Bhattacharya A, 2013, FRONT IMMUNOL, V4, DOI 10.3389/fimmu.2013.00088
   Bisgaard AK, 2017, MULT SCLER RELAT DIS, V18, P213, DOI 10.1016/j.msard.2017.10.009
   Bonilla FA, 2010, J ALLERGY CLIN IMMUN, V125, pS33, DOI 10.1016/j.jaci.2009.09.017
   Bruun JM, 2005, J CLIN ENDOCR METAB, V90, P2282, DOI 10.1210/jc.2004-1696
   Buldak L, 2016, N-S ARCH PHARMACOL, V389, P1103, DOI 10.1007/s00210-016-1277-8
   Cabreiro F, 2013, CELL, V153, P228, DOI 10.1016/j.cell.2013.02.035
   Cameron AR, 2016, CIRC RES, V119, P652, DOI 10.1161/CIRCRESAHA.116.308445
   Carestia A, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0168647
   Chandrashekara S, 2017, INT J RHEUM DIS, V20, P1457, DOI 10.1111/1756-185X.13157
   Chaudhary SC, 2012, PHOTOCHEM PHOTOBIOL, V88, P1149, DOI 10.1111/j.1751-1097.2012.01165.x
   Consolandi C, 2015, AUTOIMMUN REV, V14, P269, DOI 10.1016/j.autrev.2014.11.009
   Corsiero E, 2016, FRONT IMMUNOL, V7, DOI 10.3389/fimmu.2016.00485
   Dandona P, 2004, J CLIN ENDOCR METAB, V89, P5043, DOI 10.1210/jc.2004-0436
   de Jong YP, 2001, NAT IMMUNOL, V2, P1061, DOI 10.1038/ni720
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Delgoffe GM, 2011, NAT IMMUNOL, V12, P295, DOI 10.1038/ni.2005
   Delgoffe GM, 2009, IMMUNITY, V30, P832, DOI 10.1016/j.immuni.2009.04.014
   Deng J, 2016, ONCOTARGET, V7, P19299, DOI 10.18632/oncotarget.8244
   Denkinger CM, 2003, J IMMUNOL, V170, P1274, DOI 10.4049/jimmunol.170.3.1274
   Derrien M, 2011, FRONT MICROBIOL, V2, DOI 10.3389/fmicb.2011.00166
   Diaz A, 2017, VACCINE, V35, P2694, DOI 10.1016/j.vaccine.2017.03.078
   Dowling RJO, 2007, CANCER RES, V67, P10804, DOI 10.1158/0008-5472.CAN-07-2310
   Dumitriu IE, 2015, IMMUNOLOGY, V146, P185, DOI 10.1111/imm.12506
   Duque GA, 2014, FRONT IMMUNOL, V5, P1, DOI 10.3389/fimmu.2014.00491
   Dworacki G, 2015, IMMUNOLOGY, V146, P456, DOI 10.1111/imm.12522
   Eilenberg W, 2017, CARDIOVASC DIABETOL, V16, DOI 10.1186/s12933-017-0579-6
   Fernandez D, 2009, AUTOIMMUN REV, V8, P184, DOI 10.1016/j.autrev.2008.07.041
   Forget Patrice, 2017, BMC Res Notes, V10, P12, DOI 10.1186/s13104-016-2335-5
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Gayle S, 2017, BLOOD, V129, P1768, DOI 10.1182/blood-2016-09-736892
   Gianchecchi E, 2014, AUTOIMMUN REV, V13, P231, DOI 10.1016/j.autrev.2013.10.007
   Gong L, 2012, PHARMACOGENET GENOM, V22, P820, DOI 10.1097/FPC.0b013e3283559b22
   Graham GG, 2011, CLIN PHARMACOKINET, V50, P81, DOI 10.2165/11534750-000000000-00000
   Grant CR, 2015, AUTOIMMUN REV, V14, P845, DOI 10.1016/j.autrev.2015.05.007
   Hanninen A, 2018, GUT, V67, P1445, DOI 10.1136/gutjnl-2017-314508
   Ibanez L, 2005, HUM REPROD, V20, P2457, DOI 10.1093/humrep/dei072
   Jackuliak P, 2014, INT J ENDOCRINOL, V2014, DOI 10.1155/2014/820615
   Jang WG, 2011, BONE, V48, P885, DOI 10.1016/j.bone.2010.12.003
   Jhun J, 2016, IMMUNOPHARM IMMUNOT, V38, P103, DOI 10.3109/08923973.2015.1122619
   Jing YY, 2018, MOL CELL ENDOCRINOL, V461, P256, DOI 10.1016/j.mce.2017.09.025
   Kalender A, 2010, CELL METAB, V11, P390, DOI 10.1016/j.cmet.2010.03.014
   Kang CS, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0076520
   Kang KY, 2013, INT IMMUNOPHARMACOL, V16, P85, DOI 10.1016/j.intimp.2013.03.020
   Kaplan MJ, 2013, ARTHRITIS RES THER, V15, DOI 10.1186/ar4325
   Kasai T, 2009, J CELL PHYSIOL, V221, P740, DOI 10.1002/jcp.21917
   Keever-Taylor CA, 2007, CYTOTHERAPY, V9, P144, DOI 10.1080/14653240601145223
   Kelly B, 2015, J BIOL CHEM, V290, P20348, DOI 10.1074/jbc.M115.662114
   Kim BS, 2015, EXP MOL MED, V47, DOI 10.1038/emm.2015.26
   Kim EK, 2018, EXP MOL MED, V50, DOI 10.1038/emm.2017.245
   Kim J, 2014, J BIOL CHEM, V289, P23246, DOI 10.1074/jbc.M114.577908
   Krysiak R, 2013, PHARMACOL REP, V65, P1311, DOI 10.1016/S1734-1140(13)71489-0
   Krysiak R, 2013, METABOLISM, V62, P39, DOI 10.1016/j.metabol.2012.06.009
   Lai ZW, 2018, LANCET, V391, P1186, DOI 10.1016/S0140-6736(18)30485-9
   Lai ZW, 2012, ARTHRITIS RHEUM-US, V64, P2937, DOI 10.1002/art.34502
   Laria A, 2016, J INFLAMM RES, V9, P1, DOI 10.2147/JIR.S82320
   Le Pottier L, 2007, AUTOIMMUN REV, V6, P149, DOI 10.1016/j.autrev.2006.09.011
   Leandro MJ, 2013, ARTHRITIS RES THER, V15, DOI 10.1186/ar3908
   Leask A, 2006, ARTHRITIS RES THER, V8, DOI 10.1186/ar1976
   Lecka-Czernik Beata, 2010, Curr Osteoporos Rep, V8, P178, DOI 10.1007/s11914-010-0027-y
   Lee H, 2018, GUT MICROBES, V9, P155, DOI 10.1080/19490976.2017.1405209
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Lee SY, 2017, J IMMUNOL, V198, P2661, DOI 10.4049/jimmunol.1403088
   Lee SY, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0135858
   Lee YS, 2010, BONE, V47, P926, DOI 10.1016/j.bone.2010.08.001
   Leng L, 2011, J IMMUNOL, V186, P527, DOI 10.4049/jimmunol.1001767
   Li F, 2015, CELL PHYSIOL BIOCHEM, V37, P1279, DOI 10.1159/000430251
   Li L, 2015, ONCOTARGET, V6, P43605, DOI 10.18632/oncotarget.6186
   Lim JY, 2012, J CELL PHYSIOL, V227, P1081, DOI 10.1002/jcp.22824
   Liu Y, 2015, INT REV IMMUNOL, V34, P50, DOI 10.3109/08830185.2014.933957
   Lopez P, 2016, SCI REP-UK, V6, DOI 10.1038/srep24072
   LU J, 2015, BIOMED RES INT, V2015, P00001
   Lu MC, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0101528
   MADDUX BA, 1995, NATURE, V373, P448, DOI 10.1038/373448a0
   Mai QG, 2011, J CELL BIOCHEM, V112, P2902, DOI 10.1002/jcb.23206
   Martin-Montalvo A, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms3192
   Menegazzo L, 2018, ACTA DIABETOL, V55, P593, DOI 10.1007/s00592-018-1129-8
   Menegazzo L, 2015, ACTA DIABETOL, V52, P497, DOI 10.1007/s00592-014-0676-x
   Mikulowska A, 1997, J IMMUNOL, V158, P5514
   Morel L, 2017, NAT REV RHEUMATOL, V13, P280, DOI 10.1038/nrrheum.2017.43
   Moro F, 2013, REPROD SCI, V20, P1508, DOI 10.1177/1933719113488444
   Murray PJ, 2017, ANNU REV PHYSIOL, V79, P541, DOI 10.1146/annurev-physiol-022516-034339
   Napolitano A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100778
   Nath N, 2009, J IMMUNOL, V182, P8005, DOI 10.4049/jimmunol.0803563
   Negrotto L, 2016, JAMA NEUROL, V73, P520, DOI 10.1001/jamaneurol.2015.4807
   Nemeth T, 2012, IMMUNOL LETT, V143, P9, DOI 10.1016/j.imlet.2012.01.013
   Nishida Y, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0169845
   Noack M, 2014, AUTOIMMUN REV, V13, P668, DOI 10.1016/j.autrev.2013.12.004
   O'Neill LAJ, 2013, NATURE, V493, P346, DOI 10.1038/nature11862
   Onken B, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0008758
   Owen MR, 2000, BIOCHEM J, V348, P607, DOI 10.1042/0264-6021:3480607
   Paintlia Ajaib S, 2013, J Clin Cell Immunol, V4, DOI 10.4172/2155-9899.1000149
   Park IH, 2014, OTOLARYNG HEAD NECK, V150, P148, DOI 10.1177/0194599813513880
   Park MJ, 2016, TRANSL RES, V173, P115, DOI 10.1016/j.trsl.2016.03.006
   Park SY, 2017, FRONT IMMUNOL, V8, DOI 10.3389/fimmu.2017.01135
   Pearce EL, 2013, IMMUNITY, V38, P633, DOI 10.1016/j.immuni.2013.04.005
   Pillai S, 2011, CURR OPIN IMMUNOL, V23, P721, DOI 10.1016/j.coi.2011.10.007
   Pollak M, 2017, DIABETOLOGIA, V60, P1662, DOI 10.1007/s00125-017-4352-x
   Qin X, 2018, J CELL BIOCHEM, V119, P1074, DOI 10.1002/jcb.26275
   Radstake TRDJ, 2005, ARTHRITIS RHEUM, V52, P3020, DOI 10.1002/art.21285
   Recalcati S, 2012, AUTOIMMUN REV, V11, P883, DOI 10.1016/j.autrev.2012.03.003
   Rena G, 2017, DIABETOLOGIA, V60, P1577, DOI 10.1007/s00125-017-4342-z
   Rhoads JP, 2017, NAT REV RHEUMATOL, V13, P313, DOI 10.1038/nrrheum.2017.54
   Rothstein TL, 2013, ANN NY ACAD SCI, V1285, P97, DOI 10.1111/nyas.12137
   Sakkas LI, 2016, AUTOIMMUN REV, V15, P155, DOI 10.1016/j.autrev.2015.10.005
   Saleiro D, 2015, TRENDS IMMUNOL, V36, P21, DOI 10.1016/j.it.2014.10.006
   Sanchez E, 2006, GENES IMMUN, V7, P433, DOI 10.1038/sj.gene.6364310
   Schett G, 2012, NAT REV RHEUMATOL, V8, P656, DOI 10.1038/nrrheum.2012.153
   Shamriz O, 2016, AUTOIMMUN REV, V15, P859, DOI 10.1016/j.autrev.2016.07.012
   Shi WY, 2012, CELL DEATH DIS, V3, DOI 10.1038/cddis.2012.13
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Singh RP, 2014, AUTOIMMUN REV, V13, P1174, DOI 10.1016/j.autrev.2014.08.019
   Skapenko A, 2005, ARTHRITIS RES THER, V7, pS4, DOI 10.1186/ar1703
   Smith TJ, 2005, CLIN EXP IMMUNOL, V141, P388, DOI 10.1111/j.1365-2249.2005.02824.x
   Stefanovic V, 1999, DIABETES-METAB RES, V15, P400, DOI 10.1002/(SICI)1520-7560(199911/12)15:6<400::AID-DMRR66>3.0.CO;2-4
   Stosic-Grujicic S, 2009, AUTOIMMUN REV, V8, P244, DOI 10.1016/j.autrev.2008.07.037
   Sumarac-Dumanovic M, 2013, IMMUNOBIOLOGY, V218, P1113, DOI 10.1016/j.imbio.2013.03.002
   Tanaka Yoshiya, 2005, Current Drug Targets - Inflammation and Allergy, V4, P325, DOI 10.2174/1568010054022015
   Templeton AJ, 2014, JNCI-J NATL CANCER I, V106, DOI 10.1093/jnci/dju124
   Tomczynska M, 2016, CURR TOP MED CHEM, V16, P2223, DOI 10.2174/1568026616666160216152324
   Ursini F, 2016, J INVEST DERMATOL, V136, P1892, DOI 10.1016/j.jid.2016.05.097
   Vasamsetti SB, 2015, DIABETES, V64, P2028, DOI 10.2337/db14-1225
   Vestergaard P, 2005, DIABETOLOGIA, V48, P1292, DOI 10.1007/s00125-005-1786-3
   Wahl DR, 2010, LUPUS, V19, P1492, DOI 10.1177/0961203310373109
   Wang HT, 2015, ARTHRITIS RHEUMATOL, V67, P3190, DOI 10.1002/art.39296
   Wang HS, 2012, P NATL ACAD SCI USA, V109, P20077, DOI 10.1073/pnas.1212428109
   Weiss A, 2013, WIRES DEV BIOL, V2, P47, DOI 10.1002/wdev.86
   Wong SL, 2015, NAT MED, V21, P815, DOI 10.1038/nm.3887
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Wu N, 2011, NEOPLASMA, V58, P482, DOI 10.4149/neo_2011_06_482
   Wu SP, 2006, ARTHRITIS RHEUM-US, V54, P3661, DOI 10.1002/art.22179
   Wu YX, 2016, INT IMMUNOPHARMACOL, V36, P94, DOI 10.1016/j.intimp.2016.04.006
   Xiao H, 2016, SCI REP-UK, V6, DOI 10.1038/srep28597
   Xiao H, 2010, CARDIOVASC RES, V87, P504, DOI 10.1093/cvr/cvq066
   Xue R, 2016, EURASIP J WIREL COMM, P1, DOI 10.1186/s13638-016-0562-z
   Yang H, 2016, FRONT IMMUNOL, V7, DOI 10.3389/fimmu.2016.00302
   Yang Z, 2015, ARTHRITIS RES THER, V17, DOI 10.1186/s13075-015-0542-4
   Yeoh N, 2013, CURR RHEUMATOL REP, V15, DOI 10.1007/s11926-012-0314-y
   Yin YM, 2016, J IMMUNOL, V196, P80, DOI 10.4049/jimmunol.1501537
   Yin YM, 2015, SCI TRANSL MED, V7, DOI 10.1126/scitranslmed.aaa0835
   Yoon J, 2016, IMMUNOL CELL BIOL, V94, P719, DOI 10.1038/icb.2016.31
   Yu Yangsheng, 2013, J Clin Cell Immunol, V4
   Zhang L, 1997, MOL PHARMACOL, V51, P913, DOI 10.1124/mol.51.6.913
   Zhang SL, 2013, J IMMUNOL, V191, P1692, DOI 10.4049/jimmunol.1201767
   Zilber-Rosenberg I, 2008, FEMS MICROBIOL REV, V32, P723, DOI 10.1111/j.1574-6976.2008.00123.x
   Zoncu R, 2011, NAT REV MOL CELL BIO, V12, P21, DOI 10.1038/nrm3025
   [No title captured]
NR 155
TC 103
Z9 108
U1 1
U2 30
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-3224
J9 FRONT IMMUNOL
JI Front. Immunol.
PD JUN 4
PY 2018
VL 9
AR 1236
DI 10.3389/fimmu.2018.01236
PG 12
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA GI0FE
UT WOS:000434044000001
PM 29915588
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Prattichizzo, F
   Giuliani, A
   Mensa, E
   Sabbatinelli, J
   De Nigris, V
   Rippo, MR
   La Sala, L
   Procopio, AD
   Olivieri, F
   Ceriello, A
AF Prattichizzo, Francesco
   Giuliani, Angelica
   Mensa, Emanuela
   Sabbatinelli, Jacopo
   De Nigris, Valeria
   Rippo, Maria Rita
   La Sala, Lucia
   Procopio, Antonio Domenico
   Olivieri, Fabiola
   Ceriello, Antonio
TI Pleiotropic effects of metformin: Shaping the microbiome to manage type
   2 diabetes and postpone ageing
SO AGEING RESEARCH REVIEWS
LA English
DT Article
DE Microbiota; Gut flora; Short-chain fatty acids; Gluconeogenesis; Insulin
   sensitivity; Complex I; AMPK; mTOR; Inflammaging; Senescence
ID GLUCAGON-LIKE PEPTIDE-1; DIET-INDUCED OBESITY; CATION TRANSPORTER 1;
   HEPATIC GLUCOSE-PRODUCTION; LOW-GRADE INFLAMMATION; INCREASES LIFE-SPAN;
   GUT MICROBIOTA; INSULIN SENSITIVITY; AKKERMANSIA-MUCINIPHILA; SECRETORY
   PHENOTYPE
AB Metformin is the first-choice therapy to lower glycaemia and manage type 2 diabetes. Continuously emerging epidemiological data and experimental models are showing additional protective effects of metformin against a number of age-related diseases (ARDs), e.g., cardiovascular diseases and cancer. This evidence has prompted the design of a specific trial, i.e., the Targeting Aging with Metformin (TAME) trial, to test metformin as an anti ageing molecule. However, a unifying or prevailing mechanism of action of metformin is still debated. Here, we summarize the epidemiological data linking metformin to ARD prevention. Then, we dissect the deeply studied mechanisms of action explaining its antihyperglycemic effect and the putative mechanisms supporting its anti ageing properties, focusing on studies using clinically pertinent doses. We hypothesize that the molecular observations obtained in different models with metformin could be indirectly mediated by its effect on gut flora. Novel evidence suggests that metformin reshapes the human microbiota, promoting the growth of beneficial bacterial species and counteracting the expansion of detrimental bacterial species. In turn, this action would influence the balance between pro- and anti-inflammatory circulating factors, thereby promoting glycaemic control and healthy ageing. This framework may reconcile diverse observations, providing information for designing further studies to elucidate the complex interplay between metformin and the metabiome harboured in mammalian body compartments, thereby paving the way for innovative, bacterial-based therapeutics to manage type 2 diabetes and foster a longer healthspan.
C1 [Prattichizzo, Francesco; La Sala, Lucia; Ceriello, Antonio] IRCCS MultiMed, Via Fantoli 16-15, Milan, Italy.
   [Giuliani, Angelica; Mensa, Emanuela; Sabbatinelli, Jacopo; Rippo, Maria Rita; Procopio, Antonio Domenico; Olivieri, Fabiola] Univ Politecn Marche, Dept Clin & Mol Sci, DISCLIMO, Ancona, Italy.
   [De Nigris, Valeria; Ceriello, Antonio] Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain.
   [Procopio, Antonio Domenico; Olivieri, Fabiola] IRCCS INRCA, Ctr Clin Pathol & Innovat Therapy, Italian Natl Res Ctr Aging, Ancona, Italy.
   [Ceriello, Antonio] Ctr Invest Biomed Red Diabet & Enfermedades Metab, Madrid, Spain.
C3 IRCCS Multimedica; Marche Polytechnic University; University of
   Barcelona; Hospital Clinic de Barcelona; IDIBAPS; IRCCS INRCA; CIBER -
   Centro de Investigacion Biomedica en Red; CIBERDEM
RP Prattichizzo, F (通讯作者)，IRCCS MultiMed, Via Fantoli 16-15, Milan, Italy.
EM francesco.prattichizzo@multimedica.it
RI Prattichizzo, Francesco/J-3046-2018; Sabbatinelli, Jacopo/U-1851-2018;
   Giuliani, Angelica/AAB-9024-2019; Olivieri, Fabiola/K-6465-2016; La
   Sala, Lucia/AAC-3458-2022; La Sala, Lucia/A-4467-2019; Procopio, Antonio
   Domenico/AAB-2451-2021
OI Prattichizzo, Francesco/0000-0002-2959-2658; Sabbatinelli,
   Jacopo/0000-0001-9947-6778; Olivieri, Fabiola/0000-0002-9606-1144; La
   Sala, Lucia/0000-0002-7580-1377; La Sala, Lucia/0000-0002-7580-1377;
   Procopio, Antonio Domenico/0000-0001-6897-8724; RIPPO, Maria
   Rita/0000-0003-3024-3495; Giuliani, Angelica/0000-0002-8477-8519
FU La Marato de TV3; IDIBAPS
FX This work was supported in part by grants from La Marato de TV3 and
   IDIBAPS to A.C.
CR Almaca J, 2014, P NATL ACAD SCI USA, V111, P17612, DOI 10.1073/pnas.1414053111
   Andersson C, 2012, BMJ OPEN, V2, DOI 10.1136/bmjopen-2011-000433
   Andrzejewski S, 2014, CANCER METAB, V2, DOI 10.1186/2049-3002-2-12
   Andujar-Plata P, 2012, DIABETES RES CLIN PR, V95, P1, DOI 10.1016/j.diabres.2011.09.022
   Anisimov VN, 2008, CELL CYCLE, V7, P2769, DOI 10.4161/cc.7.17.6625
   Anisimov VN, 2011, AGING-US, V3, P148, DOI 10.18632/aging.100273
   Anisimov VN, 2010, AGING-US, V2, P760, DOI 10.18632/aging.100230
   Asemi Z, 2013, ANN NUTR METAB, V63, P1, DOI 10.1159/000349922
   Backhed F, 2007, P NATL ACAD SCI USA, V104, P979, DOI 10.1073/pnas.0605374104
   Bailey CJ, 2008, DIABETOLOGIA, V51, P1552, DOI 10.1007/s00125-008-1053-5
   BAILEY CJ, 1994, BRIT J PHARMACOL, V112, P671, DOI 10.1111/j.1476-5381.1994.tb13128.x
   Balakumar M, 2018, EUR J NUTR, V57, P279, DOI 10.1007/s00394-016-1317-7
   Banerjee J, 2016, METABOLISM, V65, P1679, DOI 10.1016/j.metabol.2016.06.011
   Bannister CA, 2014, DIABETES OBES METAB, V16, P1165, DOI 10.1111/dom.12354
   Barzilai N, 2016, CELL METAB, V23, P1060, DOI 10.1016/j.cmet.2016.05.011
   Bauer PV, 2018, CELL METAB, V27, P101, DOI 10.1016/j.cmet.2017.09.019
   Baur JA, 2014, CELL METAB, V20, P197, DOI 10.1016/j.cmet.2014.07.013
   Beaumont M., 2018, FASEB J
   Berard E, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0095671
   Biagi E, 2017, MECH AGEING DEV, V165, P180, DOI 10.1016/j.mad.2016.12.013
   Biagi E, 2016, CURR BIOL, V26, P1480, DOI 10.1016/j.cub.2016.04.016
   Biagi PL, 1999, MECH AGEING DEV, V107, P181, DOI 10.1016/S0047-6374(98)00148-1
   Blagosklonny MV, 2013, CANCER BIOL THER, V14, P1092, DOI 10.4161/cbt.27350
   Bluher M, 2003, SCIENCE, V299, P572, DOI 10.1126/science.1078223
   Bo S, 2012, DIABETES OBES METAB, V14, P23, DOI 10.1111/j.1463-1326.2011.01480.x
   Bodmer M, 2010, DIABETES CARE, V33, P1304, DOI 10.2337/dc09-1791
   Boulange CL, 2016, GENOME MED, V8, DOI 10.1186/s13073-016-0303-2
   Boussageon R, 2012, PLOS MED, V9, DOI 10.1371/journal.pmed.1001204
   Bridges HR, 2014, BIOCHEM J, V462, P475, DOI 10.1042/BJ20140620
   Buse JB, 2016, DIABETES CARE, V39, P198, DOI 10.2337/dc15-0488
   But A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0113162
   Cabreiro F, 2013, CELL, V153, P228, DOI 10.1016/j.cell.2013.02.035
   Calder PC, 2017, AGEING RES REV, V40, P95, DOI 10.1016/j.arr.2017.09.001
   Cameron AR, 2016, CIRC RES, V119, P652, DOI 10.1161/CIRCRESAHA.116.308445
   Campbell JM, 2017, AGEING RES REV, V40, P31, DOI 10.1016/j.arr.2017.08.003
   Cani PD, 2007, DIABETOLOGIA, V50, P2374, DOI 10.1007/s00125-007-0791-0
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Cani PD, 2012, GUT MICROBES, V3, P279, DOI 10.4161/gmic.19625
   Cani PD, 2011, PHARMACOL THERAPEUT, V130, P202, DOI 10.1016/j.pharmthera.2011.01.012
   Cani PD, 2006, DIABETES, V55, P1484, DOI 10.2337/db05-1360
   Chelakkot C, 2018, EXP MOL MED, V50, DOI 10.1038/emm.2017.282
   Chen J., 2017, ELIFE, V6
   Chen JJ, 2012, BRIT J NUTR, V107, P1429, DOI 10.1017/S0007114511004491
   Chiang John Y L, 2017, Liver Res, V1, P3, DOI 10.1016/j.livres.2017.05.001
   Chien HC, 2016, DRUG METAB DISPOS, V44, P356, DOI 10.1124/dmd.115.066647
   Childs BG, 2015, NAT MED, V21, P1424, DOI 10.1038/nm.4000
   Chimerel C, 2014, CELL REP, V9, P1202, DOI 10.1016/j.celrep.2014.10.032
   Dao MC, 2016, GUT, V65, P426, DOI 10.1136/gutjnl-2014-308778
   De Haes W, 2014, P NATL ACAD SCI USA, V111, pE2501, DOI 10.1073/pnas.1321776111
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   de Mello VD, 2017, SCI REP-UK, V7, DOI 10.1038/srep46337
   De Vadder F, 2016, CELL METAB, V24, P151, DOI 10.1016/j.cmet.2016.06.013
   den Besten G, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0136364
   den Besten G, 2015, DIABETES, V64, P2398, DOI 10.2337/db14-1213
   Dinakaran V, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0105221
   Donohoe DR, 2011, CELL METAB, V13, P517, DOI 10.1016/j.cmet.2011.02.018
   Drucker DJ, 2006, LANCET, V368, P1696, DOI 10.1016/S0140-6736(06)69705-5
   Drucker DJ, 2016, CELL METAB, V24, P15, DOI 10.1016/j.cmet.2016.06.009
   Duca FA, 2015, NAT MED, V21, P506, DOI 10.1038/nm.3787
   Dujic T, 2015, DIABETES, V64, P1786, DOI 10.2337/db14-1388
   Eamin EE, 2013, J NUTR, V143, P1872, DOI 10.3945/jn.113.179549
   Eckburg PB, 2005, SCIENCE, V308, P1635, DOI 10.1126/science.1110591
   El-Mir MY, 2000, J BIOL CHEM, V275, P223, DOI 10.1074/jbc.275.1.223
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Fang JQ, 2018, AGING CELL, V17, DOI 10.1111/acel.12765
   Fiorentino TV, 2017, J CLIN ENDOCR METAB, V102, P3979, DOI 10.1210/jc.2017-00348
   Fontana L, 2018, AGING CELL, V17, DOI 10.1111/acel.12746
   Foretz M, 2010, J CLIN INVEST, V120, P2355, DOI 10.1172/JCI40671
   Forouzandeh F, 2014, J AM HEART ASSOC, V3, DOI 10.1161/JAHA.114.001202
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Franceschi C, 2000, ANN NY ACAD SCI, V908, P244
   Franceschi C, 2003, BIOCHEM SOC T, V31, P457, DOI 10.1042/BST0310457
   Franceschi C, 2017, TRENDS ENDOCRIN MET, V28, P199, DOI 10.1016/j.tem.2016.09.005
   Franchi L, 2012, NAT IMMUNOL, V13, P325, DOI 10.1038/ni.2231
   Friedrich T, 2000, FEBS LETT, V479, P1, DOI 10.1016/S0014-5793(00)01867-6
   Fujisaka S, 2018, CELL REP, V22, P3072, DOI 10.1016/j.celrep.2018.02.060
   Fujisaka S, 2016, J CLIN INVEST, V126, P4430, DOI 10.1172/JCI86674
   Fullerton MD, 2013, NAT MED, V19, P1649, DOI 10.1038/nm.3372
   Fulop T, 2018, FRONT IMMUNOL, V8, DOI 10.3389/fimmu.2017.01960
   Gall WE, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0010883
   Ghosh S, 2015, J GERONTOL A-BIOL, V70, P232, DOI 10.1093/gerona/glu067
   Gladyshev VN, 2016, AGING CELL, V15, P594, DOI 10.1111/acel.12480
   Gorboulev V, 2018, MOL PHARMACOL, V93, P402, DOI 10.1124/mol.117.110767
   GORDON HA, 1966, J GERONTOL, V21, P380, DOI 10.1093/geronj/21.3.380
   Gormsen LC, 2016, J NUCL MED, V57, P1920, DOI 10.2967/jnumed.116.177774
   Graham GG, 2011, CLIN PHARMACOKINET, V50, P81, DOI 10.2165/11534750-000000000-00000
   Guigoz Y, 2008, CURR OPIN CLIN NUTR, V11, P13, DOI 10.1097/MCO.0b013e3282f2bfdf
   Halicka HD, 2011, AGING-US, V3, P1028, DOI 10.18632/aging.100397
   Hawley SA, 2010, CELL METAB, V11, P554, DOI 10.1016/j.cmet.2010.04.001
   He L, 2015, CELL METAB, V21, P159, DOI 10.1016/j.cmet.2015.01.003
   Hong Y, 2008, J CLIN PHARMACOL, V48, P696, DOI 10.1177/0091270008316884
   Hotamisligil GS, 2017, NATURE, V542, P177, DOI 10.1038/nature21363
   Howell JJ, 2017, CELL METAB, V25, P463, DOI 10.1016/j.cmet.2016.12.009
   Hull RL, 2005, DIABETES, V54, P2235, DOI 10.2337/diabetes.54.7.2235
   Jiang CT, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms10166
   Johanns M, 2016, NAT COMMUN, V7, DOI 10.1038/ncomms10856
   Kahn SE, 2008, DIABETES CARE, V31, P845, DOI 10.2337/dc07-2270
   Kalender A, 2010, CELL METAB, V11, P390, DOI 10.1016/j.cmet.2010.03.014
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kilkkinen A, 2008, INT J CANCER, V123, P2152, DOI 10.1002/ijc.23622
   Kim KA, 2016, BMC MICROBIOL, V16, DOI 10.1186/s12866-016-0625-7
   Kimura I, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms2852
   Koren O, 2011, P NATL ACAD SCI USA, V108, P4592, DOI 10.1073/pnas.1011383107
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Tran L, 2013, J GERONTOL A-BIOL, V68, P1045, DOI 10.1093/gerona/glt106
   Li AY, 2016, MOL CELL ENDOCRINOL, V434, P36, DOI 10.1016/j.mce.2016.06.008
   Libby G, 2009, DIABETES CARE, V32, P1620, DOI 10.2337/dc08-2175
   Lin HC, 2015, JAMA OPHTHALMOL, V133, P915, DOI 10.1001/jamaophthalmol.2015.1440
   Lopez-Otin C, 2016, CELL, V166, P802, DOI 10.1016/j.cell.2016.07.031
   Lopez-Otin C, 2013, CELL, V153, P1194, DOI 10.1016/j.cell.2013.05.039
   Lord JM, 2003, BRIT MED J, V327, P951, DOI 10.1136/bmj.327.7421.951
   Lustgarten MS, 2016, FRONT GENET, V7, DOI 10.3389/fgene.2016.00212
   Madiraju AK, 2014, NATURE, V510, P542, DOI 10.1038/nature13270
   Maida A, 2011, DIABETOLOGIA, V54, P339, DOI 10.1007/s00125-010-1937-z
   Maier L, 2018, NATURE, V555, P623, DOI 10.1038/nature25979
   Mardinoglu A, 2016, CELL METAB, V23, P10, DOI 10.1016/j.cmet.2015.12.012
   Mardinoglu A, 2015, MOL SYST BIOL, V11, DOI 10.15252/msb.20156487
   Martin-Montalvo A, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms3192
   Maruthur NM, 2016, ANN INTERN MED, V164, P740, DOI 10.7326/M15-2650
   Mikkelsen KH, 2016, DIABETES OBES METAB, V18, P444, DOI 10.1111/dom.12637
   Mikkelsen K. H., 2016, AGEING RES REV, V48, P87
   Miller RA, 2013, NATURE, V494, P256, DOI 10.1038/nature11808
   Moiseeva O, 2013, AGING CELL, V12, P489, DOI 10.1111/acel.12075
   Monami M, 2017, INT J CARDIOL, V240, P414, DOI 10.1016/j.ijcard.2017.03.163
   Mor A, 2016, BMJ OPEN, V6, DOI 10.1136/bmjopen-2016-011523
   Mulherin AJ, 2011, ENDOCRINOLOGY, V152, P4610, DOI 10.1210/en.2011-1485
   Nair Anroop B, 2016, J Basic Clin Pharm, V7, P27, DOI 10.4103/0976-0105.177703
   Natali A, 2006, DIABETOLOGIA, V49, P434, DOI 10.1007/s00125-006-0141-7
   Newman JC, 2016, J GERONTOL A-BIOL, V71, P1424, DOI 10.1093/gerona/glw149
   Ng TP, 2014, J ALZHEIMERS DIS, V41, P61, DOI 10.3233/JAD-131901
   Noren Hooten N, 2016, AGING CELL, V15, P572, DOI 10.1111/acel.12469
   Olivieri F, 2018, MEDIAT INFLAMM, V2018, DOI 10.1155/2018/9076485
   Onken B, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0008758
   Owen MR, 2000, BIOCHEM J, V348, P607, DOI 10.1042/0264-6021:3480607
   Plovier H, 2017, NAT MED, V23, P107, DOI 10.1038/nm.4236
   Prattichizzo F, 2018, REDOX BIOL, V15, P170, DOI 10.1016/j.redox.2017.12.001
   Prattichizzo F, 2018, AGEING RES REV, V41, P1, DOI 10.1016/j.arr.2017.10.003
   Pryor R, 2015, BIOCHEM J, V471, P307, DOI 10.1042/BJ20150497
   Pujadas G, 2017, ENDOCRINE, V56, P509, DOI 10.1007/s12020-016-1052-0
   Pussinen PJ, 2011, DIABETES CARE, V34, P392, DOI 10.2337/dc10-1676
   Qian F, 2012, AGING CELL, V11, P104, DOI 10.1111/j.1474-9726.2011.00759.x
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Rampelli S, 2013, AGING-US, V5, P902, DOI 10.18632/aging.100623
   Ravcheev DA, 2014, FRONT MICROBIOL, V5, DOI 10.3389/fmicb.2014.00674
   Rena G, 2017, DIABETOLOGIA, V60, P1577, DOI 10.1007/s00125-017-4342-z
   Saltiel AR, 2017, J CLIN INVEST, V127, P1, DOI [10.1172/JCI92035, 10.1172/jci92035]
   Samuel BS, 2008, P NATL ACAD SCI USA, V105, P16767, DOI 10.1073/pnas.0808567105
   Schieber AMP, 2015, SCIENCE, V350, P558, DOI 10.1126/science.aac6468
   Schneeberger M, 2015, SCI REP-UK, V5, DOI 10.1038/srep16643
   Scudellari M, 2015, NATURE, V517, P426, DOI 10.1038/517426a
   Selman C, 2011, PHILOS T R SOC B, V366, P99, DOI 10.1098/rstb.2010.0243
   Seshasai SRK, 2011, NEW ENGL J MED, V364, P829, DOI 10.1056/NEJMoa1008862
   Sharon G, 2014, CELL METAB, V20, P719, DOI 10.1016/j.cmet.2014.10.016
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Shu Y, 2007, J CLIN INVEST, V117, P1422, DOI 10.1172/JCI30558
   Stang M, 1999, DIABETES CARE, V22, P925, DOI 10.2337/diacare.22.6.925
   Stearns JC, 2011, SCI REP-UK, V1, DOI 10.1038/srep00170
   SUM CF, 1992, DIABETIC MED, V9, P61, DOI 10.1111/j.1464-5491.1992.tb01716.x
   Sundelin EIO, 2017, CLIN PHARMACOL THER, V102, P841, DOI 10.1002/cpt.701
   Tchkonia T, 2010, AGING CELL, V9, P667, DOI 10.1111/j.1474-9726.2010.00608.x
   Thevaranjan N, 2017, CELL HOST MICROBE, V21, P455, DOI 10.1016/j.chom.2017.03.002
   Thomas C, 2009, CELL METAB, V10, P167, DOI 10.1016/j.cmet.2009.08.001
   Tremaroli V, 2012, NATURE, V489, P242, DOI 10.1038/nature11552
   Triggle CR, 2017, ACTA PHYSIOL, V219, P138, DOI 10.1111/apha.12644
   Tropini C, 2017, CELL HOST MICROBE, V21, P433, DOI 10.1016/j.chom.2017.03.010
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Turner RC, 1998, LANCET, V352, P854, DOI 10.1016/s0140-6736(98)07037-8
   Vaiserman AM, 2017, AGEING RES REV, V35, P36, DOI 10.1016/j.arr.2017.01.001
   van Stee MF, 2018, CARDIOVASC DIABETOL, V17, DOI 10.1186/s12933-018-0738-4
   Vardarli I, 2014, DIABETES, V63, P663, DOI 10.2337/db13-0805
   Vinolo MAR, 2011, NUTRIENTS, V3, P858, DOI 10.3390/nu3100858
   Wang XK, 2015, SCI REP-UK, V5, DOI 10.1038/srep12676
   Wikoff WR, 2009, P NATL ACAD SCI USA, V106, P3698, DOI 10.1073/pnas.0812874106
   WILCOCK C, 1994, XENOBIOTICA, V24, P49, DOI 10.3109/00498259409043220
   Wiley CD, 2016, CELL METAB, V23, P1013, DOI 10.1016/j.cmet.2016.05.010
   Witters LA, 2001, J CLIN INVEST, V108, P1105, DOI 10.1172/JCI14178
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Wu LF, 2016, CELL, V167, P1705, DOI 10.1016/j.cell.2016.11.055
   Xu GS, 2015, FREE RADICAL BIO MED, V87, P15, DOI 10.1016/j.freeradbiomed.2015.05.045
   Xu M, 2015, ELIFE, V4, DOI 10.7554/eLife.12997
   Yaku K, 2012, MOL CELL BIOCHEM, V370, P7, DOI 10.1007/s11010-012-1392-x
   Yang YZ, 2017, GASTROENTEROLOGY, V152, P851, DOI 10.1053/j.gastro.2016.11.018
   Yoon MS, 2016, NUTRIENTS, V8, DOI 10.3390/nu8070405
   Youm YH, 2013, CELL METAB, V18, P519, DOI 10.1016/j.cmet.2013.09.010
   Yu TC, 2017, CELL, V170, P548, DOI 10.1016/j.cell.2017.07.008
   Zhang CS, 2016, CELL METAB, V24, P521, DOI 10.1016/j.cmet.2016.09.003
   Zhang QQ, 2016, MEDICINA-LITHUANIA, V52, P28, DOI 10.1016/j.medici.2015.11.008
   Zhou KX, 2009, DIABETES, V58, P1434, DOI 10.2337/db08-0896
NR 188
TC 58
Z9 61
U1 1
U2 40
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 1568-1637
EI 1872-9649
J9 AGEING RES REV
JI Ageing Res. Rev.
PD DEC
PY 2018
VL 48
BP 87
EP 98
DI 10.1016/j.arr.2018.10.003
PG 12
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cell Biology; Geriatrics & Gerontology
GA HC4RI
UT WOS:000451791500008
PM 30336272
DA 2023-06-08
ER

PT J
AU Trujillo-Del Rio, C
   Tortajada-Perez, J
   Gomez-Escribano, AP
   Castera, F
   Peiro, C
   Millan, JM
   Herrero, MJ
   Vazquez-Manrique, RP
AF Trujillo-Del Rio, C.
   Tortajada-Perez, J.
   Gomez-Escribano, A. P.
   Castera, F.
   Peiro, C.
   Millan, J. M.
   Herrero, M. J.
   Vazquez-Manrique, R. P.
TI Metformin to treat Huntington disease: A pleiotropic drug against a
   multi-system disorder
SO MECHANISMS OF AGEING AND DEVELOPMENT
LA English
DT Article
DE Huntington disease; Metformin; AMPK; Pleiotropic effects; Gut
   microbiome; Pharmacogenetics
ID ACTIVATED PROTEIN-KINASE; GUT MICROBIOME; GENETIC-VARIATION; SLC47A1
   GENE; MONOAMINE TRANSPORTER; TRINUCLEOTIDE REPEAT; DIABETES-MELLITUS;
   SIGNALING PATHWAY; MESSENGER-RNA; WILD-TYPE
AB Huntington disease (HD) is a neurodegenerative disorder produced by an expansion of CAG repeats in the HTT gene. Patients of HD show involuntary movements, cognitive decline and psychiatric impairment. People carrying abnormally long expansions of CAGs (more than 35 CAG repeats) produce mutant huntingtin (mHtt), which encodes tracks of polyglutamines (polyQs). These polyQs make the protein prone to aggregate and cause it to acquire a toxic gain of function. Principally affecting the frontal cortex and the striatum, mHtt disrupts many cellular functions. In addition, this protein is expressed ubiquitously, and some reports show that many other cell types are affected by the toxicity of mHtt. Several studies reported that metformin, a widely-used anti-diabetic drug, is neuroprotective in models of HD. Here, we provide a review of the benefits of this substance to treat HD. Metformin is a pleiotropic drug, modulating different targets such as AMPK, insulin signalling and many others. These molecules regulate autophagy, chaperone expression, and more, which in turn reduce mHtt toxicity. Moreover, metformin alters gut microbiome and its metabolic processes. The study of potential targets, interactions between the drug, host and microbiome, or genomic and pharmacogenomic approaches may allow us to design personalised medicine to treat HD.
C1 [Trujillo-Del Rio, C.; Tortajada-Perez, J.; Gomez-Escribano, A. P.; Millan, J. M.; Vazquez-Manrique, R. P.] Inst Invest Sanitaria La Fe, Lab Mol Cellular & Genom Biomed, Valencia, Spain.
   [Tortajada-Perez, J.; Gomez-Escribano, A. P.; Millan, J. M.; Vazquez-Manrique, R. P.] Joint Unit Rare Dis IIS La Fe CIPF, Valencia, Spain.
   [Gomez-Escribano, A. P.; Millan, J. M.; Vazquez-Manrique, R. P.] Ctr Invest Biomed Red Enfermedades Raras CIBERER, Madrid, Spain.
   [Castera, F.; Peiro, C.] Hosp Univ & Politecn La Fe, Serv Neurol, Valencia, Spain.
   [Herrero, M. J.] Univ Valencia, Fac Med, Pharmacol Dept, Av Blasco Ibanez 15, Valencia 46010, Spain.
   [Herrero, M. J.] Inst Invest Sanitaria La Fe, Pharmacogenet Unit, Av Fernando Abril Martorell 106, Valencia 46026, Spain.
C3 CIBER - Centro de Investigacion Biomedica en Red; CIBERER; Hospital
   Universitari i Politecnic La Fe; University of Valencia
RP Vazquez-Manrique, RP (通讯作者)，Inst Invest Sanitaria La Fe, Lab Mol Cellular & Genom Biomed, Valencia, Spain.
EM Rafael_vazquez@iislafe.es
FU Instituto de Salud Carlos III (ISCIII, Madrid, Spain) [PI17/00011,
   PI20/00114]; European Development Regional Fund ''A way to achieve
   Europe'' (ERDF) [PI17/00011, PI20/00114]; Fundacion Ramon Areces
   [CIVP19S8119]; CIBERER [ACCI-2019-22]; Generalitat Valenciana; European
   Social Fund [ACIF/2020/366]; Ayuda Miguel Gil grant (VII Convocatoria
   Ayudas a la Investigacion MEUHER, 2019 - Colegio Oficial de
   Farmaceuticos de Sevilla and Fundacion Cajasol); Asociacion Valenciana
   de Enfermedad de Huntington (AVAEH)
FX RPVM used grants (PI17/00011 and PI20/00114) funded by the Instituto de
   Salud Carlos III (ISCIII, Madrid, Spain). These grants are cofinanced by
   the European Development Regional Fund ''A way to achieve Europe''
   (ERDF). Funds from the Fundacion Ramon Areces (CIVP19S8119) and from
   CIBERER (ACCI-2019-22) were also used. CTR holds a grant by the
   Generalitat Valenciana and the European Social Fund (ACIF/2020/366).
   CIBERER is an initiative developed by the Instituto de Salud Carlos III
   in cooperative and translational research on rare diseases. RVM received
   an Ayuda Miguel Gil grant (VII Convocatoria Ayudas a la Investigacion
   MEUHER, 2019, cofinanced by Colegio Oficial de Farmaceuticos de Sevilla
   and Fundacion Cajasol). RVM has also received funds from the Asociacion
   Valenciana de Enfermedad de Huntington (AVAEH).
CR Abildtrup M, 2013, J HUNTINGTONS DIS, V2, P251, DOI 10.3233/JHD-130054
   Aditi K, 2016, SCI REP-UK, V6, DOI 10.1038/srep31411
   Rojas LBA, 2013, DIABETOL METAB SYNDR, V5, DOI 10.1186/1758-5996-5-6
   Al-Eitan LN, 2019, J PERS MED, V9, DOI 10.3390/jpm9010017
   Aladdin A, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20215338
   Arnoux I, 2018, ELIFE, V7, DOI 10.7554/eLife.38744
   Aykac A, 2020, CLIN PSYCHOPHARM NEU, V18, P174, DOI 10.9758/cpn.2020.18.2.174
   Bailey C, 2004, PRACT DIAB INT, V21, P115, DOI [DOI 10.1002/PDI.606, 10.1002/pdi.606]
   Banez-Coronel M, 2015, NEURON, V88, P667, DOI 10.1016/j.neuron.2015.10.038
   Barnes K, 2002, J CELL SCI, V115, P2433
   Bauer PV, 2018, CELL METAB, V27, P101, DOI 10.1016/j.cmet.2017.09.019
   Becker MSL, 2009, DIABETES, V58, P745, DOI 10.2337/db08-1028
   Bohanna I, 2011, NEUROBIOL DIS, V42, P475, DOI 10.1016/j.nbd.2011.02.010
   Cabreiro F, 2013, EMBO MOL MED, V5, P1300, DOI 10.1002/emmm.201100972
   Cabreiro F, 2013, CELL, V153, P228, DOI 10.1016/j.cell.2013.02.035
   Cacicedo JM, 2004, BIOCHEM BIOPH RES CO, V324, P1204, DOI 10.1016/j.bbrc.2004.09.177
   Chaves G, 2017, HELIYON, V3, DOI 10.1016/j.heliyon.2017.e00381
   Chiang MC, 2011, BBA-MOL BASIS DIS, V1812, P1111, DOI 10.1016/j.bbadis.2011.05.006
   Choi JH, 2011, CLIN PHARMACOL THER, V90, P674, DOI 10.1038/clpt.2011.165
   Chomanicova N, 2021, PHYSIOL RES, V70, P501, DOI 10.33549/physiolres.934618
   Cisbani G, 2012, CELL DEATH DIS, V3, DOI 10.1038/cddis.2012.121
   Culver BP, 2016, J HUNTINGTONS DIS, V5, P39, DOI 10.3233/JHD-150177
   Cuyas E, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00657
   Cuyas E, 2018, AGING CELL, V17, DOI 10.1111/acel.12772
   Dahlin A, 2007, NEUROSCIENCE, V146, P1193, DOI 10.1016/j.neuroscience.2007.01.072
   Dawed AY, 2019, DIABETES CARE, V42, P1027, DOI 10.2337/dc18-2182
   DeGruttola AK, 2016, INFLAMM BOWEL DIS, V22, P1137, DOI 10.1097/MIB.0000000000000750
   Didiot MC, 2018, CELL REP, V24, P2553, DOI 10.1016/j.celrep.2018.07.106
   DIFIGLIA M, 1995, NEURON, V14, P1075, DOI 10.1016/0896-6273(95)90346-1
   Du G, 2021, FRONT IMMUNOL, V11, DOI 10.3389/fimmu.2020.603594
   Dujic T, 2016, DIABETIC MED, V33, P511, DOI 10.1111/dme.13040
   Dunah AW, 2002, SCIENCE, V296, P2238, DOI 10.1126/science.1072613
   El-Mir MY, 2000, J BIOL CHEM, V275, P223, DOI 10.1074/jbc.275.1.223
   Engel K, 2004, J BIOL CHEM, V279, P50042, DOI 10.1074/jbc.M407913200
   Espada L., 2019, PHYSIOLOGY, DOI [10.1101/863357, DOI 10.1101/863357]
   Fain JN, 2001, HUM MOL GENET, V10, P145, DOI 10.1093/hmg/10.2.145
   FARRER LA, 1985, CLIN GENET, V27, P62
   Farshim PP, 2018, METHODS MOL BIOL, V1780, P97, DOI 10.1007/978-1-4939-7825-0_6
   Florez JC, 2017, DIABETOLOGIA, V60, P1648, DOI 10.1007/s00125-017-4335-y
   FOLSTEIN MF, 1975, J PSYCHIAT RES, V12, P189, DOI 10.1016/0022-3956(75)90026-6
   Ford RJ, 2015, BIOCHEM J, V468, P125, DOI 10.1042/BJ20150125
   Forouzandeh F, 2014, J AM HEART ASSOC, V3, DOI 10.1161/JAHA.114.001202
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Garcia-Alfonso P, 2022, CLIN TRANSL ONCOL, V24, P483, DOI 10.1007/s12094-021-02708-4
   Geier EG, 2013, CLIN PHARMACOL THER, V94, P636, DOI 10.1038/clpt.2013.175
   Ghosh R, 2018, ADV EXP MED BIOL, V1049, P1, DOI 10.1007/978-3-319-71779-1_1
   Gomez-Escribano AP, 2020, PHARMACOL RES, V161, DOI 10.1016/j.phrs.2020.105105
   Gong L, 2012, PHARMACOGENET GENOM, V22, P820, DOI 10.1097/FPC.0b013e3283559b22
   Goodman AOG, 2008, EXP NEUROL, V210, P691, DOI 10.1016/j.expneurol.2007.12.026
   Gormsen LC, 2016, J NUCL MED, V57, P1920, DOI 10.2967/jnumed.116.177774
   Hackam AS, 1999, PHILOS T R SOC B, V354, P1047, DOI 10.1098/rstb.1999.0457
   He L, 2015, CELL METAB, V21, P159, DOI 10.1016/j.cmet.2015.01.003
   He R, 2015, DIABETES RES CLIN PR, V109, P57, DOI 10.1016/j.diabres.2015.05.003
   Hervas D, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0179283
   Holmans PA, 2017, HUM MOL GENET, V26, pR83, DOI 10.1093/hmg/ddx261
   Horiuchi T, 2017, J BIOL CHEM, V292, P8436, DOI 10.1074/jbc.M116.769380
   Howell JJ, 2017, CELL METAB, V25, P463, DOI 10.1016/j.cmet.2016.12.009
   Jackson MA, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-018-05184-7
   Jimenez-Sanchez Maria, 2017, Cold Spring Harb Perspect Med, V7, DOI 10.1101/cshperspect.a024240
   Jin J, 2016, NEUROMOL MED, V18, P581, DOI 10.1007/s12017-016-8412-z
   Jones U, 2016, EUR RESPIR J, V48, P585, DOI 10.1183/13993003.02215-2015
   Joseph BK, 2015, J BIOL CHEM, V290, P10588, DOI 10.1074/jbc.M114.626259
   Ju TC, 2011, J CELL BIOL, V194, P209, DOI 10.1083/jcb.201105010
   Kahn S.E., 2006, N ENGL
   Kay C, 2017, HAND CLINIC, V144, P31, DOI 10.1016/B978-0-12-801893-4.00003-1
   Kickstein E., 2010, PROC NATL ACAD
   Kim JH, 2016, EXP MOL MED, V48, DOI 10.1038/emm.2015.115
   Kingwell K, 2021, NAT REV DRUG DISCOV, V20, P412, DOI 10.1038/d41573-021-00088-6
   Klunemann M, 2021, NATURE, V597, P533, DOI 10.1038/s41586-021-03891-8
   Kobe B, 1999, STRUCTURE, V7, pR91, DOI 10.1016/S0969-2126(99)80060-4
   Koepsell H, 2013, MOL ASPECTS MED, V34, P413, DOI 10.1016/j.mam.2012.10.010
   Kong G, 2020, NEUROBIOL DIS, V135, DOI 10.1016/j.nbd.2018.09.001
   Kopito RR, 2000, TRENDS CELL BIOL, V10, P524, DOI 10.1016/S0962-8924(00)01852-3
   Krauss S, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms2514
   Krobitsch S, 2011, INT J BIOCHEM CELL B, V43, P20, DOI 10.1016/j.biocel.2010.10.014
   Lane RF, 2012, J NEUROSCI, V32, P14080, DOI 10.1523/JNEUROSCI.3359-12.2012
   Lee JO, 2012, J BIOL CHEM, V287, P44121, DOI 10.1074/jbc.M112.361386
   Leoni V, 2015, BBA-MOL CELL BIOL L, V1851, P1095, DOI 10.1016/j.bbalip.2014.12.018
   Ley RE, 2005, P NATL ACAD SCI USA, V102, P11070, DOI 10.1073/pnas.0504978102
   Lunkes A, 2002, MOL CELL, V10, P259, DOI 10.1016/S1097-2765(02)00602-0
   Luthi-Carter R, 2000, HUM MOL GENET, V9, P1259, DOI 10.1093/hmg/9.9.1259
   Ma TC, 2007, NEUROSCI LETT, V411, P98, DOI 10.1016/j.neulet.2006.10.039
   Ma W, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.01336
   MACDONALD ME, 1993, CELL, V72, P971, DOI 10.1016/0092-8674(93)90585-E
   Madsen A, 2015, SCI REP-UK, V5, DOI 10.1038/srep16430
   Matthes F., 2018, CELL DEATH DIFFER
   Mazzetti AP, 2015, NEUROCHEM INT, V82, P10, DOI 10.1016/j.neuint.2015.01.008
   Melkani Girish C, 2016, React Oxyg Species (Apex), V2, P325, DOI 10.20455/ros.2016.859
   Menalled LB, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0049838
   Mielcarek M, 2015, RARE DIS, V3, DOI 10.1080/21675511.2015.1058464
   Mihaylova MM, 2011, NAT CELL BIOL, V13, P1016, DOI 10.1038/ncb2329
   Miller RA, 2013, NATURE, V494, P256, DOI 10.1038/nature11808
   Montoya A, 2006, J PSYCHIATR NEUROSCI, V31, P21
   Moon Seol Ju, 2018, Transl Clin Pharmacol, V26, P79, DOI 10.12793/tcp.2018.26.2.79
   Mousavi S, 2017, MOL BIOL RES COMMUN, V6, P91
   Nasri H, 2014, J RES MED SCI, V19, P658
   Novelle MG, 2016, CSH PERSPECT MED, V6, DOI 10.1101/cshperspect.a025932
   OBrien A.J., 2015, BIOCHEM J
   Onken B, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0008758
   Orr HT, 2012, CURR OPIN GENET DEV, V22, P251, DOI 10.1016/j.gde.2012.01.001
   Owen MR, 2000, BIOCHEM J, V348, P607, DOI 10.1042/0264-6021:3480607
   Patassini S., 2016, BIOCHIM
   Pattison JS, 2008, AUTOPHAGY, V4, P821, DOI 10.4161/auto.6502
   Pattison JS, 2008, CIRCULATION, V117, P2743, DOI 10.1161/CIRCULATIONAHA.107.750232
   Pedersen AJT, 2018, BASIC CLIN PHARMACOL, V122, P239, DOI 10.1111/bcpt.12874
   proteinatlas, HUMAN PROTEIN ATLAS
   proteinatlas, TISSUE EXPRESSION HT
   Provost JS, 2015, FRONT SYST NEUROSCI, V9, DOI 10.3389/fnsys.2015.00140
   Pryor R, 2019, CELL, V178, P1299, DOI 10.1016/j.cell.2019.08.003
   Ramamurthy Santosh, 2012, Exp Neurobiol, V21, P52, DOI 10.5607/en.2012.21.2.52
   Reiner A, 2003, MOL NEUROBIOL, V28, P259, DOI 10.1385/MN:28:3:259
   Rui YN, 2015, NAT CELL BIOL, V17, P262, DOI 10.1038/ncb3101
   Sanchis A, 2019, EXP MOL MED, V51, DOI 10.1038/s12276-019-0264-9
   Santoro AB, 2018, BRIT J CLIN PHARMACO, V84, P987, DOI 10.1111/bcp.13522
   Sanz P, 2013, FEBS J, V280, P3723, DOI 10.1111/febs.12364
   Saudou F, 2016, NEURON, V89, P910, DOI 10.1016/j.neuron.2016.02.003
   Savas JN, 2015, NEURON, V87, P764, DOI 10.1016/j.neuron.2015.08.007
   Scheperjans F., 2015, MOV DISORD
   Seo H, 2004, ANN NEUROL, V56, P319, DOI 10.1002/ana.20207
   Settanni CR, 2021, PROG NEURO-PSYCHOPH, V109, DOI 10.1016/j.pnpbp.2021.110258
   Shikata E, 2007, J HUM GENET, V52, P117, DOI 10.1007/s10038-006-0087-0
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   SHOULSON I, 1979, NEUROLOGY, V29, P1, DOI 10.1212/WNL.29.1.1
   Shu Y, 2008, CLIN PHARMACOL THER, V83, P273, DOI 10.1038/sj.clpt.6100275
   Shu Y, 2007, J CLIN INVEST, V117, P1422, DOI 10.1172/JCI30558
   Sidik H, 2020, DEV BIOL, V458, P98, DOI 10.1016/j.ydbio.2019.10.037
   Solis-Maldonado M., 2018
   Song IS, 2008, CLIN PHARMACOL THER, V84, P559, DOI 10.1038/clpt.2008.61
   Stan TL, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-75229-9
   Stepensky D, 2002, DRUG METAB DISPOS, V30, P861, DOI 10.1124/dmd.30.8.861
   Sundelin E, 2020, J CLIN ENDOCR METAB, V105, DOI 10.1210/clinem/dgaa332
   Tabrizi SJ, 2019, NEW ENGL J MED, V380, P2307, DOI 10.1056/NEJMoa1900907
   Takahashi T, 2010, J MOL CELL BIOL, V2, P180, DOI 10.1093/jmcb/mjq005
   Takano H, 2002, BMC NEUROSCI, V3, DOI 10.1186/1471-2202-3-15
   Talarico G, 2016, SCI REP-UK, V6, DOI 10.1038/srep18673
   Talukder P, 2021, APPL BIOCHEM BIOTECH, V193, P2634, DOI 10.1007/s12010-021-03523-x
   Tang BL, 2020, REV NEUROSCIENCE, V31, P297, DOI 10.1515/revneuro-2019-0072
   Thakur S, 2018, CLIN CANCER RES, V24, P4030, DOI 10.1158/1078-0432.CCR-17-3167
   Theken KN, 2020, CLIN PHARMACOL THER, V108, P191, DOI 10.1002/cpt.1830
   Thul PJ, 2017, SCIENCE, V356, DOI 10.1126/science.aal3321
   Tkac I, 2013, DIABETES OBES METAB, V15, P189, DOI 10.1111/j.1463-1326.2012.01691.x
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Turner RC, 1999, JAMA-J AM MED ASSOC, V281, P2005, DOI 10.1001/jama.281.21.2005
   Tzvetkov MV, 2009, CLIN PHARMACOL THER, V86, P299, DOI 10.1038/clpt.2009.92
   Uhlen M, 2015, SCIENCE, V347, DOI 10.1126/science.1260419
   Van Raamsdonk JM, 2007, NEUROBIOL DIS, V26, P512, DOI 10.1016/j.nbd.2007.01.006
   Vazquez-Manrique RP, 2016, HUM MOL GENET, V25, P1043, DOI 10.1093/hmg/ddv513
   Velier J, 1998, EXP NEUROL, V152, P34, DOI 10.1006/exnr.1998.6832
   Vila AV, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-019-14177-z
   Virtanen KA, 2003, DIABETES, V52, P283, DOI 10.2337/diabetes.52.2.283
   Vitet H, 2020, CURR OPIN NEUROBIOL, V63, P122, DOI 10.1016/j.conb.2020.04.001
   Vogt NM, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-13601-y
   Walter C, 2016, NEUROPHARMACOLOGY, V108, P24, DOI 10.1016/j.neuropharm.2016.04.041
   Wang C, 2014, CLIN LAB, V60, P887, DOI 10.7754/Clin.Lab.2013.130531
   Wang HX, 2016, CHINESE MED J-PEKING, V129, P2373, DOI 10.4103/0366-6999.190667
   Wang LC, 2011, CELL MOL LIFE SCI, V68, P1255, DOI 10.1007/s00018-010-0522-4
   Wasser CI, 2020, BRAIN COMMUN, V2, DOI 10.1093/braincomms/fcaa110
   Weersma RK, 2020, GUT, V69, P1510, DOI 10.1136/gutjnl-2019-320204
   Whirl-Carrillo M, 2021, CLIN PHARMACOL THER, V110, P563, DOI 10.1002/cpt.2350
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Wu LF, 2016, CELL, V167, P1705, DOI 10.1016/j.cell.2016.11.055
   Ye WQ, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0166973
   Zake DM, 2021, PLOS ONE, V16, DOI 10.1371/journal.pone.0249594
   Zecic A, 2019, GENES NUTR, V14, DOI 10.1186/s12263-019-0637-7
   Zhang FX, 2018, DRUG DES DEV THER, V12, P4163, DOI 10.2147/DDDT.S190094
   Zhernakova A, 2016, SCIENCE, V352, P565, DOI 10.1126/science.aad3369
   Zhou GC, 2001, J CLIN INVEST, V108, P1167, DOI 10.1172/JCI200113505
   Zhou XK, 2016, ONCOTARGET, V7, P873, DOI 10.18632/oncotarget.6418
   Zhou ZY, 2016, ACTA PHARMACOL SIN, V37, P1063, DOI 10.1038/aps.2016.21
   Zhu XD, 2021, FRONT CELL DEV BIOL, V8, DOI 10.3389/fcell.2020.626011
   Zimmermann M, 2021, MOL SYST BIOL, V17, DOI 10.15252/msb.202010116
   Zu T, 2020, P NATL ACAD SCI USA, V117, P18591, DOI 10.1073/pnas.2005748117
   Zuccato C, 2001, SCIENCE, V293, P493, DOI 10.1126/science.1059581
NR 173
TC 5
Z9 5
U1 1
U2 3
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0047-6374
EI 1872-6216
J9 MECH AGEING DEV
JI Mech. Ageing Dev.
PD JUN
PY 2022
VL 204
AR 111670
DI 10.1016/j.mad.2022.111670
EA APR 2022
PG 13
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Geriatrics & Gerontology
GA 1C1RG
UT WOS:000792904400007
PM 35367225
DA 2023-06-08
ER

PT J
AU Tian, JL
   Si, X
   Shu, C
   Wang, YH
   Tan, H
   Zang, ZH
   Zhang, WJ
   Xie, X
   Chen, Y
   Li, B
AF Tian, Jin-Long
   Si, Xu
   Shu, Chi
   Wang, Yue-Hua
   Tan, Hui
   Zang, Zhi-Huan
   Zhang, Wei-Jia
   Xie, Xu
   Chen, Yi
   Li, Bin
TI Synergistic Effects of Combined Anthocyanin and Metformin Treatment for
   Hyperglycemia In Vitro and In Vivo
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Article
DE anthocyanins; insulin resistance; gut microbiota; metformin;
   hypoglycemic effect
ID EXTRACT
AB The mechanism underlying the hypoglycemic effect of the simultaneous use of metformin and anthocyanin-rich foods is not yet clear. Hence, the effects and possible mechanisms of action of these substances, alone and in combination, were evaluated in insulin-resistant HepG2 cells and a diabetic mouse model. The results indicated that anthocyanin and metformin had a significant synergistic effect on glucose consumption (CI < 0.9) compared with metformin alone in HepG2 cells. In the mouse model, combined treatment (50 and 100 mg/kg metformin + anthocyanin groups) demonstrated synergistic restorative effects on the blood glucose level, insulin resistance, and organ damage in the liver, pancreas, and ileum. Additionally, combined metformin and anthocyanin treatment suppressed protein tyrosine phosphatase 1B expression and regulated the PI3K/AKT/GSK3 beta pathway. Combined treatment also altered the gut microbial composition and structure by increasing the relative abundance of beneficial bacteria and the short-chain fatty acid content. These results suggest that the use of anthocyanins can enhance the efficacy of metformin treatment for hyperglycemia and provide a reference for further clinical research regarding nutrition and supplementary treatment.
C1 [Tian, Jin-Long; Si, Xu; Shu, Chi; Wang, Yue-Hua; Tan, Hui; Zang, Zhi-Huan; Zhang, Wei-Jia; Xie, Xu; Li, Bin] Shenyang Agr Univ, Coll Food Sci, Shenyang 110866, Liaoning, Peoples R China.
   [Tian, Jin-Long; Si, Xu; Shu, Chi; Wang, Yue-Hua; Tan, Hui; Zang, Zhi-Huan; Zhang, Wei-Jia; Xie, Xu; Li, Bin] Shenyang Agr Univ, Key Lab Hlth Food Nutr & Innovat Mfg Liaoning Pro, Shenyang 110866, Liaoning, Peoples R China.
   [Chen, Yi] Nanchang Univ, State Key Lab Food Sci & Technol, Nanchang 330047, Jiangxi, Peoples R China.
C3 Shenyang Agricultural University; Shenyang Agricultural University;
   Nanchang University
RP Li, B (通讯作者)，Shenyang Agr Univ, Coll Food Sci, Shenyang 110866, Liaoning, Peoples R China.; Li, B (通讯作者)，Shenyang Agr Univ, Key Lab Hlth Food Nutr & Innovat Mfg Liaoning Pro, Shenyang 110866, Liaoning, Peoples R China.
EM libinsyau@163.com
RI Tian, Jin-Long/AAI-2300-2020
OI Tian, Jin-Long/0000-0001-7149-9441; , BIN/0000-0002-7393-2111
FU National Natural Science Foundation of China [U21A20273]; First Batch of
   Liaoning "Unveiling Leader" Scientific and Technological Projects
   [2021JH1/10400036]; China Agriculture Research System of MOF [CARS-29];
   Liaoning Province Doctoral Research Startup Fund Project [2019-BS-205];
   Scientific research fund project of Liaoning Provincial Department of
   Education [LSNQN201915]; Scientific Research Foundation of Shenyang
   Agricultural University [880418027]; China Agriculture Research System
   of MARA [CARS-29]
FX This work was supported by the National Natural Science Foundation of
   China (U21A20273), the First Batch of Liaoning "Unveiling Leader"
   Scientific and Technological Projects (2021JH1/10400036), China
   Agriculture Research System of MOF and MARA(CARS-29), Liaoning Province
   Doctoral Research Startup Fund Project (2019-BS-205), Scientific
   research fund project of Liaoning Provincial Department of Education
   (LSNQN201915) and Scientific Research Foundation of Shenyang
   Agricultural University (880418027).
CR Amer Diabet Assoc, 2021, DIABETES CARE, V44, pS34, DOI 10.2337/dc21-S003
   [Anonymous], 2015, DIABETES CARE, V38, pS1, DOI 10.2337/dc15-S001
   [Anonymous], 2005, GUID IND EST MAX SAF
   Arun G, 2020, INT J BIOL MACROMOL, V153, P1335, DOI 10.1016/j.ijbiomac.2019.10.270
   Bailey CJ, 2017, DIABETOLOGIA, V60, P1566, DOI 10.1007/s00125-017-4318-z
   Bilanda DC, 2020, J ETHNOPHARMACOL, V246, DOI 10.1016/j.jep.2019.112200
   Brownlee M, 2005, DIABETES, V54, P1615, DOI 10.2337/diabetes.54.6.1615
   Cao H, 2019, CRIT REV FOOD SCI, V59, P3371, DOI 10.1080/10408398.2018.1492900
   Chaiyasut C, 2017, PHARMACEUTICALS-BASE, V10, DOI 10.3390/ph10010003
   Chen JM, 2021, J HAZARD MATER, V411, DOI 10.1016/j.jhazmat.2020.124963
   Chen ZQ, 2018, FOOD FUNCT, V9, P426, DOI [10.1039/c7fo00983f, 10.1039/C7FO00983F]
   Cheng Z, 2020, FOOD SCI HUM WELL, V9, P245, DOI 10.1016/j.fshw.2020.04.006
   Cordts P R, 2001, Vasc Surg, V35, P107, DOI 10.1177/153857440103500204
   Donado-Pestana CM, 2021, FOOD CHEM, V340, DOI 10.1016/j.foodchem.2020.128169
   Du YL, 2018, EUR J MED CHEM, V144, P692, DOI 10.1016/j.ejmech.2017.12.064
   Garcia-Calzon S, 2020, SCI TRANSL MED, V12, DOI 10.1126/scitranslmed.aaz1803
   Giaccari A, 2021, DIABETES CARE, V44, P647, DOI 10.2337/dc20-1964
   Gloyn AL, 2018, LANCET DIABETES ENDO, V6, P891, DOI 10.1016/S2213-8587(18)30052-4
   Gowd V, 2017, TRENDS FOOD SCI TECH, V68, P1, DOI 10.1016/j.tifs.2017.07.015
   Guimaraes M, 2020, J AGR FOOD CHEM, V68, P7387, DOI 10.1021/acs.jafc.0c02599
   Gurung M, 2020, EBIOMEDICINE, V51, DOI 10.1016/j.ebiom.2019.11.051
   Jang HH, 2019, FOOD CHEM, V272, P688, DOI 10.1016/j.foodchem.2018.08.010
   Jeon CY, 2012, DIABETES CARE, V35, P520, DOI 10.2337/dc11-1043
   Jia LL, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-07335-0
   Jiao XY, 2019, J NUTR BIOCHEM, V64, P88, DOI 10.1016/j.jnutbio.2018.07.008
   Jinawong K, 2020, DIABETES, V69, P1411, DOI 10.2337/db19-1128
   Lee HJ, 2021, J ETHNOPHARMACOL, V265, DOI 10.1016/j.jep.2020.113236
   Lee M, 2020, J AGR FOOD CHEM, V68, P12011, DOI 10.1021/acs.jafc.0c04891
   Li B, 2021, SPECTROCHIM ACTA A, V259, DOI 10.1016/j.saa.2021.119910
   Li B, 2020, MOL NUTR FOOD RES, V64, DOI 10.1002/mnfr.201901315
   Li DN, 2016, J FOOD COMPOS ANAL, V47, P1, DOI 10.1016/j.jfca.2015.09.005
   Liao ZZ, 2019, MOLECULES, V24, DOI 10.3390/molecules24101906
   Liu HL, 2021, NAT COMMUN, V12, DOI 10.1038/s41467-020-20275-0
   Maranzano E, 2020, J NEUROSURG SCI, V64, P37, DOI 10.23736/S0390-5616.16.03745-0
   Mattioli R, 2020, MOLECULES, V25, DOI 10.3390/molecules25173809
   Oliveira H, 2020, MOLECULES, V25, DOI 10.3390/molecules25173813
   Pedersen HK, 2016, NATURE, V535, P376, DOI 10.1038/nature18646
   Peniche-Pavia HA, 2020, J AGR FOOD CHEM, V68, P5980, DOI 10.1021/acs.jafc.9b06336
   Rahman MH, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-19576-1
   Rathore PK, 2016, J THEOR BIOL, V391, P95, DOI 10.1016/j.jtbi.2015.12.004
   Rodrigues RR, 2021, NAT COMMUN, V12, DOI 10.1038/s41467-020-20313-x
   Rodriguez-Daza MC, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-58863-1
   Si X, 2020, J AGR FOOD CHEM, V68, P8185, DOI 10.1021/acs.jafc.0c01931
   Skyler JS, 2017, DIABETES, V66, P241, DOI 10.2337/db16-0806
   Su HM, 2020, J AGR FOOD CHEM, V68, P13025, DOI 10.1021/acs.jafc.9b03338
   Sun XY, 2019, FOOD CHEM, V279, P63, DOI 10.1016/j.foodchem.2018.11.139
   Tian JL, 2021, FOOD CHEM, V341, DOI 10.1016/j.foodchem.2020.128149
   Tian JL, 2019, J AGR FOOD CHEM, V67, P13624, DOI 10.1021/acs.jafc.9b06155
   Towfigh S, 2000, J SURG RES, V88, P160, DOI 10.1006/jsre.1999.5767
   Veberic R, 2015, LWT-FOOD SCI TECHNOL, V60, P509, DOI 10.1016/j.lwt.2014.08.033
   Wan ZK, 2007, BIOORG MED CHEM LETT, V17, P2913, DOI 10.1016/j.bmcl.2007.02.043
   Wang CY, 2020, J AGR FOOD CHEM, V68, P2393, DOI 10.1021/acs.jafc.9b07687
   Wang YH, 2019, J AGR FOOD CHEM, V67, P625, DOI 10.1021/acs.jafc.8b06209
   Whyte AR, 2018, NUTRIENTS, V10, DOI 10.3390/nu10060660
   Xu F, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0147748
   Xu J, 2020, J AGR FOOD CHEM, V68, P14452, DOI 10.1021/acs.jafc.0c04429
   Xu Y, 2019, CHEM COMMUN, V55, P39, DOI 10.1039/c8cc07985d
   Yang WY, 2014, LANCET DIABETES ENDO, V2, P992, DOI 10.1016/S2213-8587(14)70136-6
   Yang Z, 2018, FOOD FUNCT, V9, P397, DOI [10.1039/c7fo01489a, 10.1039/C7FO01489A]
   Zhang B, 2013, J AGR FOOD CHEM, V61, P8765, DOI 10.1021/jf4012399
   Zhang BW, 2017, J AGR FOOD CHEM, V65, P8319, DOI 10.1021/acs.jafc.7b02531
   Zhang F, 2021, NAT COMMUN, V12, DOI 10.1038/s41467-020-20240-x
   Zheng JL, 2018, J AGR FOOD CHEM, V66, P5821, DOI [10.1021/acsjafc.8b00829, 10.1021/acs.jafc.8b00829]
NR 63
TC 5
Z9 5
U1 13
U2 49
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
EI 1520-5118
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD FEB 2
PY 2022
VL 70
IS 4
BP 1182
EP 1195
DI 10.1021/acs.jafc.1c07799
EA JAN 2022
PG 14
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA ZL3PW
UT WOS:000750667800001
PM 35044756
DA 2023-06-08
ER

PT J
AU Hung, WW
   Peng, P
   Tsai, YC
   Jhou, PS
   Chang, CC
   Hsieh, CC
   Su, YC
   Dai, CY
   Hung, WC
AF Hung, Wei-Wen
   Peng, Po
   Tsai, Yi-Chun
   Jhou, Pei-Syuan
   Chang, Chen-Chia
   Hsieh, Ching-Chun
   Su, Yong-Chao
   Dai, Chia-Yen
   Hung, Wei-Chun
TI Gut microbiota compositions and metabolic functions in type 2 diabetes
   differ with glycemic durability to metformin monotherapy
SO DIABETES RESEARCH AND CLINICAL PRACTICE
LA English
DT Article
DE Gut microbiota; Type 2 diabetes; Metformin; Glycemic durability;
   Thiamine; Lipopolysaccharide
ID CHAIN FATTY-ACIDS; STATISTICAL-ANALYSIS; MASS-SPECTROMETRY;
   QUANTIFICATION; HYPERGLYCEMIA; ASSOCIATION; MECHANISMS; METAGENOME
AB Aims: The metabolic derangements in type 2 diabetes have been attributed to composi-tional changes in the gut microbiota. Metformin, the first-line treatment for type 2 diabetes, has been found to modulate the gut microbiota. However, no literature has reported the associations between the composition of the gut microbiota and glycemic durability to metformin monotherapy.
   Methods: A total of 375 patients with type 2 diabetes were recruited, among which 14 and 11 patients were eligible as the metformin durable group and nondurable group, respectively. Fecal samples were collected to analyze the gut microbiota by Illumina sequencing of the 16S rRNA gene, and PICRUSt2 was adopted to infer microbial functional differences.
   Results: Although the two groups had similar biochemical profiles and microbial metabo-lites, the pattern of microbiota clustering was different. The intra-group diversity was sig-nificantly reduced in the durable group. For the microbial metabolic pathways, the biosynthesis of thiamine and lipopolysaccharide was dominant in the durable group.
   Conclusions: There were different compositions of gut microbiota with unique microbial metabolic pathways between type 2 diabetes with and without glycemic durability to met-formin monotherapy. Microbial salvage by increasing thiamine biosynthesis might be ben-eficial for the metformin durable group to maintain optimal glycemic control. (c) 2021 Elsevier B.V. All rights reserved.
C1 [Hung, Wei-Wen; Hsieh, Ching-Chun] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Endocrinol & Metab, Kaohsiung, Taiwan.
   [Peng, Po; Su, Yong-Chao] Kaohsiung Med Univ, Dept Biomed Sci & Environm Biol, Kaohsiung, Taiwan.
   [Tsai, Yi-Chun; Hsieh, Ching-Chun] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Nephrol, Kaohsiung, Taiwan.
   [Tsai, Yi-Chun; Hsieh, Ching-Chun] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Gen Med, Kaohsiung, Taiwan.
   [Jhou, Pei-Syuan; Chang, Chen-Chia; Hung, Wei-Chun] Kaohsiung Med Univ, Coll Med, Dept Microbiol & Immunol, Kaohsiung, Taiwan.
   [Jhou, Pei-Syuan; Dai, Chia-Yen] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Hepatobiliary, Kaohsiung, Taiwan.
C3 Kaohsiung Medical University; Kaohsiung Medical University Hospital;
   Kaohsiung Medical University; Kaohsiung Medical University; Kaohsiung
   Medical University Hospital; Kaohsiung Medical University; Kaohsiung
   Medical University Hospital; Kaohsiung Medical University; Kaohsiung
   Medical University; Kaohsiung Medical University Hospital
RP Hung, WC (通讯作者)，Kaohsiung Med Univ, Coll Med, Dept Microbiol & Immunol, Kaohsiung, Taiwan.
EM wchung@kmu.edu.tw
FU Kaohsiung Medical University Hospital [KMUH106-6M11, KMUH1077M10,
   KMUH108-8R20]; Ministry of Science and Technology of Taiwan [MOST
   108-2635-B-037004]
FX This work was supported by the Kaohsiung Medical University Hospital
   (grant numbers KMUH106-6M11, KMUH1077M10 and KMUH108-8R20) and the
   Ministry of Science and Technology of Taiwan (grant number MOST
   108-2635-B-037004).
CR Allin KH, 2015, EUR J ENDOCRINOL, V172, pR167, DOI 10.1530/EJE-14-0874
   Bolyen E, 2019, NAT BIOTECHNOL, V37, P852, DOI 10.1038/s41587-019-0209-9
   Brunkwall L, 2017, DIABETOLOGIA, V60, P943, DOI 10.1007/s00125-017-4278-3
   Bryrup T, 2019, DIABETOLOGIA, V62, P1024, DOI 10.1007/s00125-019-4848-7
   Buse JB, 2020, DIABETOLOGIA, V63, P221, DOI 10.1007/s00125-019-05039-w
   Callahan BJ, 2016, NAT METHODS, V13, P581, DOI [10.1038/NMETH.3869, 10.1038/nmeth.3869]
   Cao TTB, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.573891
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   DeFronzo RA, 2009, DIABETES, V58, P773, DOI 10.2337/db09-9028
   Douglas GM, 2020, NAT BIOTECHNOL, V38, P685, DOI 10.1038/s41587-020-0548-6
   Elbere I, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0204317
   Foretz M, 2019, NAT REV ENDOCRINOL, V15, P569, DOI 10.1038/s41574-019-0242-2
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Frank LL, 2015, JPEN-PARENTER ENTER, V39, P503, DOI 10.1177/0148607114565245
   Guo XL, 2008, ANAEROBE, V14, P224, DOI 10.1016/j.anaerobe.2008.04.001
   Han J, 2015, ANAL CHIM ACTA, V854, P86, DOI 10.1016/j.aca.2014.11.015
   Hung W.-W., 2020, MED MICROECOLOGY, V3
   Kahn SE, 2006, NEW ENGL J MED, V355, P2427, DOI 10.1056/NEJMoa066224
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Klikauer T, 2016, TRIPLEC-COMMUN CAPIT, V14, P260
   Larkin JR, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0053175
   Liang XM, 2015, MOL PHARMACEUT, V12, P4301, DOI 10.1021/acs.molpharmaceut.5b00501
   Maguire D, 2018, CLIN NUTR ESPEN, V25, P8, DOI 10.1016/j.clnesp.2018.02.007
   Mitra A, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0120520
   Nakajima H, 2020, LIFE-BASEL, V10, DOI 10.3390/life10090195
   Pacal L, 2014, WORLD J DIABETES, V5, P288, DOI 10.4239/wjd.v5.i3.288
   Page GLJ, 2011, INT J CLIN PRACT, V65, P684, DOI 10.1111/j.1742-1241.2011.02680.x
   Parks DH, 2014, BIOINFORMATICS, V30, P3123, DOI 10.1093/bioinformatics/btu494
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Quast C, 2013, NUCLEIC ACIDS RES, V41, pD590, DOI 10.1093/nar/gks1219
   Rena G, 2017, DIABETOLOGIA, V60, P1577, DOI 10.1007/s00125-017-4342-z
   Sanchez-Rangel E, 2017, DIABETOLOGIA, V60, P1586, DOI 10.1007/s00125-017-4336-x
   Segata N, 2011, GENOME BIOL, V12, DOI 10.1186/gb-2011-12-6-r60
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Thornalley PJ, 2007, DIABETOLOGIA, V50, P2164, DOI 10.1007/s00125-007-0771-4
   Tsai MY, 2005, J LAB CLIN MED, V145, P323, DOI 10.1016/j.lab.2005.03.009
   van Eijk HMH, 2009, J CHROMATOGR B, V877, P719, DOI 10.1016/j.jchromb.2009.01.039
   Willis AD, 2019, FRONT MICROBIOL, V10, DOI 10.3389/fmicb.2019.02407
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Xia YL, 2017, GENES DIS, V4, P138, DOI 10.1016/j.gendis.2017.06.001
   Zeng MF, 2018, J CHROMATOGR B, V1083, P137, DOI 10.1016/j.jchromb.2018.02.040
   Zhang X, 2015, SCI REP-UK, V5, DOI 10.1038/srep14405
NR 42
TC 6
Z9 6
U1 2
U2 15
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0168-8227
EI 1872-8227
J9 DIABETES RES CLIN PR
JI Diabetes Res. Clin. Pract.
PD APR
PY 2021
VL 174
AR 108731
DI 10.1016/j.diabres.2021.108731
EA MAR 2021
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA RY1LK
UT WOS:000647677900004
PM 33676995
DA 2023-06-08
ER

PT J
AU Liu, WH
   Wang, Y
   Luo, JQ
   Liu, MZ
   Luo, ZY
AF Liu, Wenhui
   Wang, Ying
   Luo, Jianquan
   Liu, Mouze
   Luo, Zhiying
TI Pleiotropic Effects of Metformin on the Antitumor Efficiency of Immune
   Checkpoint Inhibitors
SO FRONTIERS IN IMMUNOLOGY
LA English
DT Review
DE metformin; immune check inhibitors; PD-1; PD-L1; pleiotropic; gut
   microbiome
AB Cancer is an important threat to public health because of its high morbidity and mortality. In recent decades, immune checkpoint inhibitors (ICIs) have ushered a new therapeutic era in clinical oncology. The rapid development of immune checkpoint therapy is due to its inspiring clinical efficacy in a group of cancer types. Metformin, an effective agent for the management of type 2 diabetes mellitus (T2DM), has shown beneficial effects on cancer prevention and cancer treatment. Emerging studies have suggested that metformin in combination with ICI treatment could improve the anticancer effects of ICIs. Hence, we conducted a review to summarize the effects of metformin on ICI therapy. We also review the pleiotropic mechanisms of metformin combined with ICIs in cancer therapy, including its direct and indirect effects on the host immune system.
C1 [Liu, Wenhui; Wang, Ying; Luo, Jianquan; Liu, Mouze; Luo, Zhiying] Cent South Univ, Dept Pharm, Xiangya Hosp 2, Changsha, Peoples R China.
   [Liu, Wenhui; Wang, Ying; Luo, Jianquan; Liu, Mouze; Luo, Zhiying] Cent South Univ, Inst Clin Pharm, Changsha, Peoples R China.
C3 Central South University; Central South University
RP Luo, ZY (通讯作者)，Cent South Univ, Dept Pharm, Xiangya Hosp 2, Changsha, Peoples R China.; Luo, ZY (通讯作者)，Cent South Univ, Inst Clin Pharm, Changsha, Peoples R China.
EM lzhy199089@csu.edu.cn
RI Luo, Jianquan/D-3515-2014
FU Natural Science Foundation of Hunan Province China [2017JJ3462,
   2020JJ5822]; National Natural Scientific Foundation of China [82003883]
FX This work was supported by the Natural Science Foundation of Hunan
   Province China (Grant No: 2017JJ3462, 2020JJ5822) and National Natural
   Scientific Foundation of China (82003883).
CR Afzal MZ, 2019, LUNG CANCER MANAG, V8, DOI 10.2217/lmt-2018-0016
   Afzal MZ, 2018, J IMMUNOTHER CANCER, V6, DOI 10.1186/s40425-018-0375-1
   Alfei F, 2017, TRENDS MOL MED, V23, P769, DOI 10.1016/j.molmed.2017.07.006
   [Anonymous], 2018, NAT REV DRUG DISCOV, V17, P854, DOI 10.1038/nrd.2018.210
   Binnewies M, 2018, NAT MED, V24, P541, DOI 10.1038/s41591-018-0014-x
   Bonanni B, 2012, J CLIN ONCOL, V30, P2593, DOI 10.1200/JCO.2011.39.3769
   Borghaei H, 2015, NEW ENGL J MED, V373, P1627, DOI 10.1056/NEJMoa1507643
   Brahmer J, 2015, NEW ENGL J MED, V373, P123, DOI 10.1056/NEJMoa1504627
   Cao X, 2017, J CANCER, V8, P2532, DOI 10.7150/jca.19750
   Cha JH, 2018, MOL CELL, V71, P606, DOI 10.1016/j.molcel.2018.07.030
   Chapman NM, 2020, NAT REV IMMUNOL, V20, P55, DOI 10.1038/s41577-019-0203-y
   Coyle C, 2016, ANN ONCOL, V27, P2184, DOI 10.1093/annonc/mdw410
   Dankner R, 2019, AM J EPIDEMIOL, V188, P1794, DOI 10.1093/aje/kwz157
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Dempsey LA, 2018, NAT IMMUNOL, V19, P1039, DOI 10.1038/s41590-018-0224-x
   Derosa L, 2018, ANN ONCOL, V29, P1437, DOI 10.1093/annonc/mdy103
   Ding L, 2015, ONCOTARGET, V6, P36441, DOI 10.18632/oncotarget.5541
   Dodd D, 2017, NATURE, V551, P648, DOI 10.1038/nature24661
   Eikawa S, 2015, P NATL ACAD SCI USA, V112, P1809, DOI 10.1073/pnas.1417636112
   Evans JMM, 2005, BMJ-BRIT MED J, V330, P1304, DOI 10.1136/bmj.38415.708634.F7
   Franco F, 2020, NAT METAB, V2, P1001, DOI 10.1038/s42255-020-00280-9
   Gandhi S, 2020, IMMUNOTHERAPY-UK, V12, P141, DOI 10.2217/imt-2019-0064
   Ghoneim HE, 2017, CELL, V170, DOI 10.1016/j.cell.2017.06.007
   Gopalakrishnan V, 2018, SCIENCE, V359, P97, DOI 10.1126/science.aan4236
   Gopalakrishnan V, 2018, CANCER CELL, V33, P570, DOI 10.1016/j.ccell.2018.03.015
   Haikala HM, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-08541-2
   Hakozaki T, 2019, ONCOL LETT, V17, P2946, DOI 10.3892/ol.2019.9899
   He H, 2015, CANCER J, V21, P70, DOI 10.1097/PPO.0000000000000103
   Joshua AM, 2014, PROSTATE CANCER P D, V17, P252, DOI 10.1038/pcan.2014.20
   Kalinsky K, 2014, CANCER INVEST, V32, P150, DOI 10.3109/07357907.2014.889706
   Kim Y, 2021, CANCER IMMUNOL IMMUN, V70, P961, DOI 10.1007/s00262-020-02703-8
   Klement JD, 2018, J CLIN INVEST, V128, P5549, DOI 10.1172/JCI123360
   Kordes S, 2015, LANCET ONCOL, V16, P839, DOI 10.1016/S1470-2045(15)00027-3
   Kunisada Y, 2017, EBIOMEDICINE, V25, P154, DOI 10.1016/j.ebiom.2017.10.009
   Lee J, 2019, NATURE, V568, P254, DOI 10.1038/s41586-019-1005-x
   Li LF, 2018, CANCER RES, V78, P1779, DOI 10.1158/0008-5472.CAN-17-2460
   Lu S, 2019, JAMA ONCOL, V5, P1195, DOI 10.1001/jamaoncol.2019.1549
   Lurienne L, 2020, J THORAC ONCOL, V15, P1147, DOI 10.1016/j.jtho.2020.03.002
   Mager LF, 2020, SCIENCE, V369, P1481, DOI 10.1126/science.abc3421
   McCreight LJ, 2016, DIABETOLOGIA, V59, P426, DOI 10.1007/s00125-015-3844-9
   Michot JM, 2016, EUR J CANCER, V54, P139, DOI 10.1016/j.ejca.2015.11.016
   Niraula S, 2012, BREAST CANCER RES TR, V135, P821, DOI 10.1007/s10549-012-2223-1
   Pascal M, 2018, FRONT IMMUNOL, V9, DOI 10.3389/fimmu.2018.01584
   Pinato DJ, 2019, JAMA ONCOL, V5, P1774, DOI 10.1001/jamaoncol.2019.2785
   Pitt JM, 2016, ANN ONCOL, V27, P1482, DOI 10.1093/annonc/mdw168
   Podhorecka M, 2017, POSTEP HIG MED DOSW, V71, P170
   Pollack SM, 2018, J CLIN ONCOL, V36, P125, DOI 10.1200/JCO.2017.75.1610
   Pollak M, 2017, DIABETOLOGIA, V60, P1662, DOI 10.1007/s00125-017-4352-x
   Prattichizzo F, 2018, AGEING RES REV, V48, P87, DOI 10.1016/j.arr.2018.10.003
   Prince SS, 2019, VIRCHOWS ARCH, V474, P475, DOI 10.1007/s00428-018-2445-7
   Proto C, 2019, CANCER TREAT REV, V75, P39, DOI 10.1016/j.ctrv.2019.03.004
   Reni M, 2016, CLIN CANCER RES, V22, P1076, DOI 10.1158/1078-0432.CCR-15-1722
   Roager HM, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-018-05470-4
   Rodriguez J, 2018, CURR OPIN CLIN NUTR, V21, P294, DOI 10.1097/MCO.0000000000000468
   Rooks MG, 2016, NAT REV IMMUNOL, V16, P341, DOI 10.1038/nri.2016.42
   Routy B, 2018, SCIENCE, V359, P91, DOI 10.1126/science.aan3706
   Roviello G, 2017, EUR J CANCER, V86, P257, DOI 10.1016/j.ejca.2017.09.018
   Sakoda LC, 2015, CANCER PREV RES, V8, P174, DOI 10.1158/1940-6207.CAPR-14-0291
   Samuel SM, 2019, BIOMOLECULES, V9, DOI 10.3390/biom9120846
   Scharping NE, 2017, CANCER IMMUNOL RES, V5, P9, DOI 10.1158/2326-6066.CIR-16-0103
   Schuler KM, 2015, CANCER MED-US, V4, P161, DOI 10.1002/cam4.353
   Schulten HJ, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19102850
   Schwartz DJ, 2019, CRIT REV CL LAB SCI, V56, P567, DOI 10.1080/10408363.2019.1660303
   Shen XF, 2020, LIFE SCI, V256, DOI 10.1016/j.lfs.2020.117923
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Shindo Y, 2019, CANCERS, V11, DOI 10.3390/cancers11091223
   Siska PJ, 2017, JCI INSIGHT, V2, DOI 10.1172/jci.insight.93411
   Sivan A, 2015, SCIENCE, V350, P1084, DOI 10.1126/science.aac4255
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Svaton M, 2020, ANTICANCER RES, V40, P2209, DOI 10.21873/anticanres.14182
   Uehara T, 2019, INT IMMUNOL, V31, P187, DOI 10.1093/intimm/dxy079
   Vancura A, 2018, TRENDS PHARMACOL SCI, V39, P867, DOI 10.1016/j.tips.2018.07.006
   Verdura S, 2019, ONCOIMMUNOLOGY, V8, DOI 10.1080/2162402X.2019.1633235
   Wan GX, 2018, CELL PHYSIOL BIOCHEM, V49, P837, DOI 10.1159/000493214
   Wang DY, 2020, ONCOLOGIST, V25, pE602, DOI 10.1634/theoncologist.2019-0518
   Wang JC, 2017, ONCOTARGET, V8, P73892, DOI 10.18632/oncotarget.18029
   Wang SH, 2020, CLIN CANCER RES, V26, P4921, DOI 10.1158/1078-0432.CCR-20-0113
   Wang YC, 2019, JAMA ONCOL, V5, P1008, DOI 10.1001/jamaoncol.2019.0393
   Wei F, 2013, P NATL ACAD SCI USA, V110, pE2480, DOI 10.1073/pnas.1305394110
   Wolchok JD, 2017, NEW ENGL J MED, V377, P1345, DOI 10.1056/NEJMoa1709684
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Xue J, 2019, EUR J PHARMACOL, V859, DOI 10.1016/j.ejphar.2019.172541
   Yanik EL, 2017, JAMA ONCOL, V3, P974, DOI 10.1001/jamaoncol.2017.0115
   Yendamuri S, 2019, J THORAC ONCOL, V14, P2181, DOI 10.1016/j.jtho.2019.07.020
   Zhang JJ, 2019, AM J TRANSL RES, V11, P6965
   Zhou HQ, 2019, CANCER CHEMOTH PHARM, V83, P599, DOI 10.1007/s00280-018-03763-5
NR 86
TC 17
Z9 17
U1 3
U2 16
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-3224
J9 FRONT IMMUNOL
JI Front. Immunol.
PD FEB 2
PY 2021
VL 11
AR 586760
DI 10.3389/fimmu.2020.586760
PG 10
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA QH4BZ
UT WOS:000618222000001
PM 33603734
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Lee, Y
   Kim, AH
   Kim, E
   Lee, S
   Yu, KS
   Jang, IJ
   Chung, JY
   Cho, JY
AF Lee, Yujin
   Kim, Andrew HyoungJin
   Kim, Eunwoo
   Lee, SeungHwan
   Yu, Kyung-Sang
   Jang, In-Jin
   Chung, Jae-Yong
   Cho, Joo-Youn
TI Changes in the gut microbiome influence the hypoglycemic effect of
   metformin through the altered metabolism of branched-chain and
   nonessential amino acids
SO DIABETES RESEARCH AND CLINICAL PRACTICE
LA English
DT Article
DE Metformin; Gut microbiome; Metabolomics; Hypoglycemic effect
ID ACTIVATED PROTEIN-KINASE; PPAR-GAMMA; INSULIN; OBESITY; GLUCOSE;
   URINARY; MECHANISM; PLASMA; MUSCLE; SERUM
AB Aims: Although metformin has been reported to affect the gut microbiome, the mechanism has not been fully determined. We explained the potential underlying mechanisms of metformin through a multiomics approach.
   Methods: An open-label and single-arm clinical trial involving 20 healthy Korean was conducted. Serum glucose and insulin concentrations were measured, and stool samples were collected to analyze the microbiome. Untargeted metabolomic profiling of plasma, urine, and stool samples was performed by GC-TOF-MS. Network analysis was applied to infer the mechanism of the hypoglycemic effect of metformin.
   Results: The relative abundances of Escherichia, Romboutsia, Intestinibacter, and Clostridium were changed by metformin treatment. Additionally, the relative abundances of metabolites, including carbohydrates, amino acids, and fatty acids, were changed. These changes were correlated with energy metabolism, gluconeogenesis, and branched-chain amino acid metabolism, which are major metabolic pathways related to the hypoglycemic effect.
   Conclusions: We observed that specific changes in metabolites may affect hypoglycemic effects through both pathways related to AMPK activation and microbial changes. Energy metabolism was mainly related to hypoglycemic effects. In particular, branched-chain amino acid metabolism and gluconeogenesis were related to microbial metabolites. Our results will help uncover the potential underlying mechanisms of metformin through AMPK and the microbiome. (C) 2021 The Author(s). Published by Elsevier B.V.
C1 [Lee, Yujin; Kim, Eunwoo; Lee, SeungHwan; Yu, Kyung-Sang; Jang, In-Jin; Chung, Jae-Yong; Cho, Joo-Youn] Seoul Natl Univ, Dept Clin Pharmacol & Therapeut, Coll Med & Hosp, Seoul 03080, South Korea.
   [Kim, Andrew HyoungJin] Washington Univ, Sch Med, Dept Med, Div Infect Dis, St Louis, MO 63110 USA.
   [Chung, Jae-Yong] Seoul Natl Univ, Clin Trials Ctr, Bundang Hosp, Seongnam, South Korea.
   [Yu, Kyung-Sang; Cho, Joo-Youn] Seoul Natl Univ, Dept Biomed Sci, Coll Med, Seoul 03080, South Korea.
C3 Seoul National University (SNU); Washington University (WUSTL); Seoul
   National University (SNU); Seoul National University (SNU)
RP Chung, JY; Cho, JY (通讯作者)，Seoul Natl Univ, Dept Clin Pharmacol & Therapeut, Coll Med, 101 Daehak Ro, Seoul 03080, South Korea.; Chung, JY (通讯作者)，Bundang Hosp, Seoul 03080, South Korea.
EM yoojinlee@snu.ac.kr; andrewhyoungjinkim@wustl.edu; eunoo1212@snu.ac.kr;
   leejh413@snu.ac.kr; ksyu@snu.ac.kr; ijjang@snu.ac.kr; jychung@snubh.org;
   joocho@snu.ac.kr
RI Jang, In-Jin/J-2786-2012; Cho, Joo-Youn/ABC-2044-2021; Chung, Jae
   Yong/J-5646-2012; Cho, Joo-Youn/J-5672-2012
OI Cho, Joo-Youn/0000-0001-9270-8273; Cho, Joo-Youn/0000-0001-9270-8273;
   Chung, Jae Yong/0000-0003-4188-2786
FU National Research Foundation of Korea (NRF) - Korean government (MSIT)
   [NRF-2016M3A9B6902851, NRF-2018R1D1A1B07044406]
FX This work was supported by the National Research Foundation of Korea
   (NRF) funded by the Korean government (MSIT) [grant numbers
   NRF-2016M3A9B6902851 and NRF-2018R1D1A1B07044406].
CR Adams SH, 2011, ADV NUTR, V2, P445, DOI 10.3945/an.111.000737
   Ahmadian M, 2013, NAT MED, V19, P557, DOI 10.1038/nm.3159
   Aitken JD, 2013, NAT REV GASTRO HEPAT, V10, P72, DOI 10.1038/nrgastro.2012.252
   Bailey CJ, 2008, DIABETOLOGIA, V51, P1552, DOI 10.1007/s00125-008-1053-5
   Barupal DK, 2012, BMC BIOINFORMATICS, V13, DOI 10.1186/1471-2105-13-99
   BONORA E, 1984, CURR MED RES OPIN, V9, P47, DOI 10.1185/03007998409109558
   Bukowiecka-Matusiak M, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0203799
   Buse JB, 2016, DIABETES CARE, V39, P198, DOI 10.2337/dc15-0488
   Calvani R, 2010, INT J OBESITY, V34, P1095, DOI 10.1038/ijo.2010.44
   Chong J, 2018, NUCLEIC ACIDS RES, V46, pW486, DOI 10.1093/nar/gky310
   Clarke SF, 2012, GUT MICROBES, V3, P186, DOI 10.4161/gmic.20168
   Cummings BP, 2013, DIS MODEL MECH, V6, P443, DOI 10.1242/dmm.010421
   Dann SG, 2007, TRENDS MOL MED, V13, P252, DOI 10.1016/j.molmed.2007.04.002
   Dave M, 2012, TRANSL RES, V160, P246, DOI 10.1016/j.trsl.2012.05.003
   DEFRONZO RA, 1991, J CLIN ENDOCR METAB, V73, P1294, DOI 10.1210/jcem-73-6-1294
   Dhariwal A, 2017, NUCLEIC ACIDS RES, V45, pW180, DOI 10.1093/nar/gkx295
   Eliakim-Raz N, 2015, EUR J CLIN MICROBIOL, V34, P1201, DOI 10.1007/s10096-015-2348-3
   Fiehn Oliver, 2016, Curr Protoc Mol Biol, V114, DOI 10.1002/0471142727.mb3004s114
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Graham GG, 2011, CLIN PHARMACOKINET, V50, P81, DOI 10.2165/11534750-000000000-00000
   Hardie DG, 2008, FEBS LETT, V582, P81, DOI 10.1016/j.febslet.2007.11.018
   Hong JH, 2012, DIS MARKERS, V33, P193, DOI [10.1155/2012/734718, 10.3233/DMA-2012-0925]
   Huo TG, 2015, BIOMED CHROMATOGR, V29, P115, DOI 10.1002/bmc.3247
   Johnson CH, 2016, NAT REV MOL CELL BIO, V17, P451, DOI 10.1038/nrm.2016.25
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kim E, CLIN TRANSL SCI, V2021
   Kim E, 2008, NAT CELL BIOL, V10, P935, DOI 10.1038/ncb1753
   Kraegen EW, 2008, P NATL ACAD SCI USA, V105, P7627, DOI 10.1073/pnas.0803901105
   Lee WJ, 2006, BIOCHEM BIOPH RES CO, V340, P291, DOI 10.1016/j.bbrc.2005.12.011
   Li MJ, 2013, AM J PHYSIOL-RENAL, V304, pF1317, DOI 10.1152/ajprenal.00536.2012
   Li M, 2008, P NATL ACAD SCI USA, V105, P2117, DOI 10.1073/pnas.0712038105
   Liou AP, 2013, SCI TRANSL MED, V5, DOI 10.1126/scitranslmed.3005687
   Mansour HH, 2017, ARCH BIOCHEM BIOPHYS, V616, P13, DOI 10.1016/j.abb.2017.01.005
   Marshall Stephen, 2006, Sci STKE, V2006, pre7
   Millard P, 2017, PLOS COMPUT BIOL, V13, DOI 10.1371/journal.pcbi.1005396
   Napolitano A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100778
   Oliveira A, PLOS COMPUTAT BIOL, V17
   Pedersen HK, 2016, NATURE, V535, P376, DOI 10.1038/nature18646
   Rena G, 2017, DIABETOLOGIA, V60, P1577, DOI 10.1007/s00125-017-4342-z
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Smoot ME, 2011, BIOINFORMATICS, V27, P431, DOI 10.1093/bioinformatics/btq675
   STUMVOLL M, 1995, NEW ENGL J MED, V333, P550, DOI 10.1056/NEJM199508313330903
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Wilding JPH, 2007, DIABETIC MED, V24, P934, DOI 10.1111/j.1464-5491.2007.02186.x
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Zhang YY, 2007, DIABETES, V56, P1647, DOI 10.2337/db07-0123
   Zhao XJ, 2010, METABOLOMICS, V6, P362, DOI 10.1007/s11306-010-0203-1
   Zhernakova A, 2016, SCIENCE, V352, P565, DOI 10.1126/science.aad3369
   Zhou GC, 2001, J CLIN INVEST, V108, P1167, DOI 10.1172/JCI200113505
NR 50
TC 9
Z9 9
U1 2
U2 16
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0168-8227
EI 1872-8227
J9 DIABETES RES CLIN PR
JI Diabetes Res. Clin. Pract.
PD AUG
PY 2021
VL 178
AR 108985
DI 10.1016/j.diabres.2021.108985
EA AUG 2021
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA UM3PQ
UT WOS:000693246300032
PM 34329692
OA hybrid
DA 2023-06-08
ER

PT J
AU Tong, XL
   Xu, J
   Lian, FM
   Yu, XT
   Zhao, YF
   Xu, LP
   Zhang, MH
   Zhao, XY
   Shen, J
   Wu, SP
   Pang, XY
   Tian, JX
   Zhang, CH
   Zhou, Q
   Wang, LH
   Pang, B
   Chen, F
   Peng, ZP
   Wang, J
   Zhen, Z
   Fang, C
   Li, M
   Chen, LM
   Zhao, LP
AF Tong, Xiaolin
   Xu, Jia
   Lian, Fengmei
   Yu, Xiaotong
   Zhao, Yufeng
   Xu, Lipeng
   Zhang, Menghui
   Zhao, Xiyan
   Shen, Jian
   Wu, Shengping
   Pang, Xiaoyan
   Tian, Jiaxing
   Zhang, Chenhong
   Zhou, Qiang
   Wang, Linhua
   Pang, Bing
   Chen, Feng
   Peng, Zhiping
   Wang, Jing
   Zhen, Zhong
   Fang, Chao
   Li, Min
   Chen, Limei
   Zhao, Liping
TI Structural Alteration of Gut Microbiota during the Amelioration of Human
   Type 2 Diabetes with Hyperlipidemia by Metformin and a Traditional
   Chinese Herbal Formula: a Multicenter, Randomized, Open Label Clinical
   Trial
SO MBIO
LA English
DT Article
DE clinical trial; gut microbiota; hyperlipidemia; metformin; traditional
   Chinese medicine; type 2 diabetes
ID ACTIVATED PROTEIN-KINASE; RED YEAST RICE; HIGH-FAT DIET; HUMAN FECES;
   METABOLIC SYNDROME; SP NOV.; DOUBLE-BLIND; OBESITY; INFLAMMATION;
   DYSLIPIDEMIA
AB Accumulating evidence implicates gut microbiota as promising targets for the treatment of type 2 diabetes mellitus (T2DM). With a randomized clinical trial, we tested the hypothesis that alteration of gut microbiota may be involved in the alleviation of T2DM with hyperlipidemia by metformin and a specifically designed herbal formula (AMC). Four hundred fifty patients with T2DM and hyperlipidemia were randomly assigned to either the metformin- or AMC-treated group. After 12 weeks of treatment, 100 patients were randomly selected from each group and assessed for clinical improvement. The effects of the two drugs on the intestinal microbiota were evaluated by analyzing the V3 and V4 regions of the 16S rRNA gene by Illumina sequencing and multivariate statistical methods. Both metformin and AMC significantly alleviated hyperglycemia and hyperlipidemia and shifted gut microbiota structure in diabetic patients. They significantly increased a coabundant group represented by Blautia spp., which significantly correlated with the improvements in glucose and lipid homeostasis. However, AMC showed better efficacies in improving homeostasis model assessment of insulin resistance (HOMA-IR) and plasma triglyceride and also exerted a larger effect on gut microbiota. Furthermore, only AMC increased the coabundant group represented by Faecalibacterium spp., which was previously reported to be associated with the alleviation of T2DM in a randomized clinical trial. Metformin and the Chinese herbal formula may ameliorate type 2 diabetes with hyperlipidemia via enriching beneficial bacteria, such as Blautia and Faecalibacterium spp.
   IMPORTANCE Metabolic diseases such as T2DM and obesity have become a worldwide public health threat. Accumulating evidence indicates that gut microbiota can causatively arouse metabolic diseases, and thus the gut microbiota serves as a promising target for disease control. In this study, we evaluated the role of gut microbiota during improvements in hyperglycemia and hyperlipidemia by two drugs: metformin and a specifically designed Chinese herbal formula ( AMC) for diabetic patients with hyperlipidemia. Both drugs significantly ameliorated blood glucose and lipid levels and shifted the gut microbiota. Blautia spp. were identified as being associated with improvements in glucose and lipid homeostasis for both drugs. AMC exerted larger effects on the gut microbiota together with better efficacies in improving HOMA-IR and plasma triglyceride levels, which were associated with the enrichment of Faecalibacterium spp. In brief, these data suggest that gut microbiota might be involved in the alleviation of diabetes with hyperlipidemia by metformin and the AMC herbal formula.
C1 [Tong, Xiaolin; Lian, Fengmei; Yu, Xiaotong; Xu, Lipeng; Zhao, Xiyan; Wu, Shengping; Tian, Jiaxing; Zhou, Qiang; Pang, Bing; Peng, Zhiping; Zhen, Zhong; Li, Min] China Acad Chinese Med Sci, Guanganmen Hosp, Beijing, Peoples R China.
   [Xu, Jia; Zhang, Menghui; Pang, Xiaoyan; Zhang, Chenhong; Wang, Linhua; Chen, Feng; Wang, Jing; Fang, Chao; Chen, Limei; Zhao, Liping] Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, State Key Lab Microbial Metab, Shanghai, Peoples R China.
   [Yu, Xiaotong; Zhao, Xiyan; Wu, Shengping; Tian, Jiaxing] Beijing Univ Chinese Med, Grad Sch, Beijing, Peoples R China.
   [Zhao, Yufeng; Shen, Jian; Zhao, Liping] Shanghai Jiao Tong Univ, Shanghai Ctr Syst Biomed, Shanghai, Peoples R China.
C3 China Academy of Chinese Medical Sciences; Guang'anmen Hospital, CACMS;
   Shanghai Jiao Tong University; Beijing University of Chinese Medicine;
   Shanghai Jiao Tong University
RP Tong, XL (通讯作者)，China Acad Chinese Med Sci, Guanganmen Hosp, Beijing, Peoples R China.; Zhao, LP (通讯作者)，Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, State Key Lab Microbial Metab, Shanghai, Peoples R China.; Zhao, LP (通讯作者)，Shanghai Jiao Tong Univ, Shanghai Ctr Syst Biomed, Shanghai, Peoples R China.
EM xiaolintong66@sina.com; lpzhao@sjtu.edu.cn
RI WANG, JINGYI/GSJ-1241-2022; Xu, Jia/GSD-6115-2022; zhang,
   menghui/Q-3752-2016; zhang, chenhong/HCH-9822-2022; wang,
   jing/GVT-8700-2022
OI Xu, Jia/0000-0002-3341-7668; Wang, Jing/0000-0003-0547-6780; Yu,
   Xiaotong/0000-0002-8184-5181
FU National Natural Science Foundation of China [81273720, 31330005,
   81401141]; Scientific Specialized Program of Traditional Chinese
   Medicine of China [201007004]
FX This work was supported by the National Natural Science Foundation of
   China (no. 81273720, 31330005, and 81401141) and the Scientific
   Specialized Program of Traditional Chinese Medicine of China (no.
   201007004).
CR Aguiree F, 2013, IDF DIABETES ATLAS
   Baxter NT, 2014, MICROBIOME, V2, DOI 10.1186/2049-2618-2-20
   Becker DJ, 2009, ANN INTERN MED, V150, P830, DOI 10.7326/0003-4819-150-12-200906160-00006
   BONORA E, 1984, CURR MED RES OPIN, V9, P47, DOI 10.1185/03007998409109558
   Caporaso JG, 2010, NAT METHODS, V7, P335, DOI 10.1038/nmeth.f.303
   Choi HC, 2013, NUTRITION, V29, P1110, DOI 10.1016/j.nut.2013.02.015
   Cittadini A, 2012, DIABETES, V61, P944, DOI 10.2337/db11-1132
   Donath MY, 2011, NAT REV IMMUNOL, V11, P98, DOI 10.1038/nri2925
   Duca FA, 2014, DIABETES, V63, P1624, DOI 10.2337/db13-1526
   Duncan SH, 2002, INT J SYST EVOL MICR, V52, P2141, DOI 10.1099/00207713-52-6-2141
   Edgar RC, 2010, BIOINFORMATICS, V26, P2460, DOI 10.1093/bioinformatics/btq461
   Fei N, 2013, ISME J, V7, P880, DOI 10.1038/ismej.2012.153
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Friedman J, 2012, PLOS COMPUT BIOL, V8, DOI 10.1371/journal.pcbi.1002687
   Fuangchan A, 2011, J ETHNOPHARMACOL, V134, P422, DOI 10.1016/j.jep.2010.12.045
   Furet JP, 2010, DIABETES, V59, P3049, DOI 10.2337/db10-0253
   Han J, 2015, J ETHNOPHARMACOL, V172, P368, DOI 10.1016/j.jep.2015.05.016
   He L, 2009, CELL, V137, P635, DOI 10.1016/j.cell.2009.03.016
   Hotamisligil GS, 2008, INT J OBESITY, V32, pS52, DOI 10.1038/ijo.2008.238
   Jenq RR, 2015, BIOL BLOOD MARROW TR, V21, P1373, DOI 10.1016/j.bbmt.2015.04.016
   Kahn SE, 2014, LANCET, V383, P1068, DOI 10.1016/S0140-6736(13)62154-6
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kim K, 2009, PHYTOMEDICINE, V16, P856, DOI 10.1016/j.phymed.2009.02.014
   Li M, 2008, P NATL ACAD SCI USA, V105, P2117, DOI 10.1073/pnas.0712038105
   Luong DQ, 2015, J PEDIATR ENDOCR MET, V28, P649, DOI 10.1515/jpem-2014-0201
   Martin R, 2015, BMC MICROBIOL, V15, DOI 10.1186/s12866-015-0400-1
   Miquel S, 2015, MBIO, V6, DOI 10.1128/mBio.00300-15
   Murri M, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-46
   Na LX, 2015, SCI REP-UK, V5, DOI 10.1038/srep10344
   Neyrinck AM, 2012, J NUTR BIOCHEM, V23, P51, DOI 10.1016/j.jnutbio.2010.10.008
   Park SK, 2013, INT J SYST EVOL MICR, V63, P599, DOI 10.1099/ijs.0.036541-0
   Park SK, 2012, INT J SYST EVOL MICR, V62, P776, DOI 10.1099/ijs.0.031625-0
   Pruski M, 2009, DIABETES CARE, V32, P1421, DOI 10.2337/dc08-2335
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Quevrain E, 2016, GUT, V65, P415, DOI 10.1136/gutjnl-2014-307649
   Rossi O, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0123013
   Sanugul K, 2005, BIOL PHARM BULL, V28, P1672, DOI 10.1248/bpb.28.1672
   Saulnier DM, 2011, GASTROENTEROLOGY, V141, P1782, DOI 10.1053/j.gastro.2011.06.072
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Shoelson SE, 2009, NAT MED, V15, P373, DOI 10.1038/nm0409-373
   Sokol H, 2008, P NATL ACAD SCI USA, V105, P16731, DOI 10.1073/pnas.0804812105
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Verhoeven V, 2015, BMC COMPLEM ALTERN M, V15, DOI 10.1186/s12906-015-0576-9
   Vijay-Kumar M, 2010, SCIENCE, V328, P228, DOI 10.1126/science.1179721
   Virdi J, 2003, J ETHNOPHARMACOL, V88, P107, DOI 10.1016/S0378-8741(03)00184-3
   Wulffele MG, 2004, J INTERN MED, V256, P1, DOI 10.1111/j.1365-2796.2004.01328.x
   Xu J, 2015, ISME J, V9, P552, DOI 10.1038/ismej.2014.177
   Zhang CH, 2015, EBIOMEDICINE, V2, P968, DOI 10.1016/j.ebiom.2015.07.007
   Zhang QP, 2016, SCI REP-UK, V6, DOI 10.1038/srep27572
   Zhang X, 2012, PLOS ONE, V7, DOI [10.1371/journal.pone.0040320, 10.1371/journal.pone.0042529]
   Zhang XY, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0071108
   Zhang X, 2015, SCI REP-UK, V5, DOI 10.1038/srep14405
   Zhang YF, 2008, J CLIN ENDOCR METAB, V93, P2559, DOI 10.1210/jc.2007-2404
   Zhao LP, 2013, NAT REV MICROBIOL, V11, P639, DOI 10.1038/nrmicro3089
   Zhou GC, 2001, J CLIN INVEST, V108, P1167, DOI 10.1172/JCI200113505
NR 55
TC 197
Z9 220
U1 24
U2 194
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 2150-7511
J9 MBIO
JI mBio
PD MAY-JUN
PY 2018
VL 9
IS 3
AR e02392-17
DI 10.1128/mBio.02392-17
PG 12
WC Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology
GA GG9WG
UT WOS:000433051200019
PM 29789365
OA Green Published, gold
HC Y
HP N
DA 2023-06-08
ER

PT J
AU Xue, J
   Li, XR
   Liu, P
   Li, K
   Sha, LP
   Yang, XL
   Zhu, LL
   Wang, Z
   Dong, YP
   Zhang, L
   Lei, H
   Zhang, XX
   Dong, XY
   Wang, H
AF Xue, Jing
   Li, Xiaorong
   Liu, Ping
   Li, Ke
   Sha, Liping
   Yang, Xiaoli
   Zhu, Lili
   Wang, Zhen
   Dong, Youping
   Zhang, Li
   Lei, Hong
   Zhang, Xiaoxia
   Dong, Xiaoying
   Wang, Hao
TI Inulin and metformin ameliorate polycystic ovary syndrome via
   anti-inflammation and modulating gut microbiota in mice
SO ENDOCRINE JOURNAL
LA English
DT Article
DE Inulin; Metformin; Polycystic ovary syndrome (PCOS); Anti-intlammation;
   Gut microbiota
ID FOLLICULAR-FLUID; WOMEN
AB Polycystic ovary syndrome (PCOS) represents an endocrine disorder, which is closely related with gut microbiota. Inulin, a kind of probiotics, has been proven to alleviate gut microbiota dysbiosis. Metformin, a biguanide agent, shows beneficial effects on chronic metabolic diseases. Our objective was to assess the effects and associated mechanisms of inulin and metforin on attenuation of PCOS in mice. Mice were divided into 4 groups: control group (CON), model group (MOD), inulin group (INU), metformin group (MET). The last three groups were fed 6 mg of dehydmepiandmsterone (DHEA) per 100 g body weight and 60% high-fat diet to generate mice model. After 21 days of intervention, mice were euthanized and associated indications were investigated. Body weight (BW) and testosterone (T) levels were significantly decreased, but estradiol (E2) levels were increased in INU or MET group, respectively. Ovary LIE staining demonstrated that inulin or metformin ameliorated PCOS morphology. inflammatory indicators from plasma and ovary including TNF-alpha, IL-6, and IL-17A were decreased in INU or MET group. Moreover, IL-10 in ovary of INU or MET group was increased. Sequencing and analysis of gut microbiota showed that compared to MOD group, Bifidobacterium was increased, but Proteobacteria, Helicobacter and Parasutterella were decreased in INU group. Helicobacter was decreased in MET group. Correlation analysis showed that gut microbiota was correlated with inflammatory factors. Our results revealed that inulin and metformin alleviated PCOS via anti-inflammation and modulating gut microbiota, which may contribute to potential clinical therapy for the disease.
C1 [Xue, Jing; Zhu, Lili; Wang, Hao] Ningxia Med Univ, Sch Basic Med Sci, Dept Pathogen Biol & Med Immunol, Shengli St 1160, Yinchuan 750004, Ningxia, Peoples R China.
   [Li, Xiaorong] Ningxia Med Univ, Ctr Reprod Med, Gen Hosp, Yinchuan 750004, Ningxia, Peoples R China.
   [Liu, Ping; Sha, Liping; Dong, Youping; Zhang, Li; Lei, Hong; Dong, Xiaoying] Ningxia Med Univ, Endocrinol Dept, Gen Hosp, Shengli St 1160, Yinchuan 750004, Ningxia, Peoples R China.
   [Li, Ke; Yang, Xiaoli; Wang, Zhen] Ningxia Med Univ, Clin Med Coll, Yinchuan 750004, Ningxia, Peoples R China.
   [Li, Ke] Ningxia Peoples Hosp, Endocrinol Dept, Yinchuan 750002, Ningxia, Peoples R China.
   [Zhang, Xiaoxia] Ningxia Med Univ, Coll Tradit Chinese Med, Yinchuan 750004, Ningxia, Peoples R China.
C3 Ningxia Medical University; Ningxia Medical University; Ningxia Medical
   University; Ningxia Medical University; Ningxia Medical University
RP Wang, H (通讯作者)，Ningxia Med Univ, Sch Basic Med Sci, Dept Pathogen Biol & Med Immunol, Shengli St 1160, Yinchuan 750004, Ningxia, Peoples R China.; Dong, XY (通讯作者)，Ningxia Med Univ, Endocrinol Dept, Gen Hosp, Shengli St 1160, Yinchuan 750004, Ningxia, Peoples R China.
EM dongxy1998@163.com; wanghaograduate@nxmu.edu.cn
FU Research and Development Plan of the 13th Fiveyear Plan of Ningxia
   Autonomous Region (the major S&T projects), China [2016BZ02]; First
   Class Discipline Construction Project in Colleges and Universities of
   Ningxia, China [NXYLXK2017A05]; Ningxia High School First-class
   Disciplines (West China first-class Disciplines Basic Medical Sciences
   at Ningxia Medical University), China [NXYLXK 2017B07]; National Key
   Research and Development Program of China, China [2016YFD0400605]
FX This work was supported by the following funds:; 1. The Research and
   Development Plan of the 13th Fiveyear Plan of Ningxia Autonomous Region
   (the major S&T projects) (Grant No. 2016BZ02), China.; 2. The First
   Class Discipline Construction Project in Colleges and Universities of
   Ningxia (Grant No. NXYLXK2017A05), China.; 3. Ningxia High School
   First-class Disciplines (West China first-class Disciplines Basic
   Medical Sciences at Ningxia Medical University) (Grant No. NXYLXK
   2017B07), China.; 4. The National Key Research and Development Program
   of China (No. 2016YFD0400605), China.
CR Angurana SK, 2018, CRIT CARE MED, V46, P1656, DOI 10.1097/CCM.0000000000003279
   Artimani T, 2018, GYNECOL ENDOCRINOL, V34, P148, DOI 10.1080/09513590.2017.1371691
   Cani PD, 2009, GUT, V58, P1091, DOI 10.1136/gut.2008.165886
   Drabinska N, 2018, NUTRIENTS, V10, DOI 10.3390/nu10020201
   Ejtahed HS, 2019, EUR J ENDOCRINOL, V180, P165, DOI [10.1530/EJE-18-0826, 10.1530/eje-18-0826]
   Escobar-Morreale HF, 2011, FERTIL STERIL, V95, P1048, DOI 10.1016/j.fertnstert.2010.11.036
   Everard A, 2014, ISME J, V8, P2116, DOI 10.1038/ismej.2014.45
   Homburg R, 2008, BEST PRACT RES CL OB, V22, P261, DOI 10.1016/j.bpobgyn.2007.07.009
   Jeong SY, 2017, GENES NUTR, V12, DOI 10.1186/s12263-017-0585-z
   John GK, 2018, GENES-BASEL, V9, DOI 10.3390/genes9030167
   Karateke A, 2018, MED PRIN PRACT, V27, P515, DOI 10.1159/000494300
   Kelley ST, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0146509
   Kelly B, 2015, J BIOL CHEM, V290, P20348, DOI 10.1074/jbc.M115.662114
   Klemenak M, 2015, DIGEST DIS SCI, V60, P3386, DOI 10.1007/s10620-015-3769-7
   Lai H, 2014, BIOL REPROD, V91, DOI 10.1095/biolreprod.114.120063
   Li K, 2019, FOOD FUNCT, V10, P1915, DOI 10.1039/c8fo02265h
   Lindheim L, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0168390
   Liu HF, 2016, NANO, V11, DOI 10.1142/S1793292016500302
   Liu R, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.00324
   Macfarlane S, 2013, ALIMENT PHARM THER, V38, P804, DOI 10.1111/apt.12453
   March WA, 2010, HUM REPROD, V25, P544, DOI 10.1093/humrep/dep399
   Naderpoor N, 2015, HUM REPROD UPDATE, V21, P560, DOI 10.1093/humupd/dmv025
   Nicolucci AC, 2017, GASTROENTEROLOGY, V153, P711, DOI 10.1053/j.gastro.2017.05.055
   Nunez-Calonge R, 2016, REPROD BIOMED ONLINE, V32, P446, DOI 10.1016/j.rbmo.2015.12.010
   Out M, 2018, DIABETES OBES METAB, V20, P219, DOI 10.1111/dom.13054
   Qiao J, 2011, HUM REPROD UPDATE, V17, P17, DOI 10.1093/humupd/dmq032
   Sabbaghi MA, 2014, IMMUNOL INVEST, V43, P617, DOI 10.3109/08820139.2014.909453
   Gholizadeh Shamasbi S, 2019, EUR J NUTR, V58, P629, DOI 10.1007/s00394-018-1648-7
   Shen J, 2013, MOL ASPECTS MED, V34, P39, DOI 10.1016/j.mam.2012.11.001
   Tremellen K, 2012, MED HYPOTHESES, V79, P104, DOI 10.1016/j.mehy.2012.04.016
   Vandeputte D, 2017, GUT, V66, P1968, DOI 10.1136/gutjnl-2016-313271
   Wang JH, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00620
   Xie Y, 2017, J MICROBIOL BIOTECHN, V27
   Zeng B, 2019, RES MICROBIOL, V170, P43, DOI 10.1016/j.resmic.2018.09.002
   Zhang DM, 2015, EUR J ENDOCRINOL, V172, DOI 10.1530/EJE-14-0589
   Zhang FF, 2019, FRONT MICROBIOL, V10, DOI 10.3389/fmicb.2019.00175
   Zhang Q, 2018, PEERJ, V6, DOI 10.7717/peerj.4446
NR 37
TC 51
Z9 56
U1 6
U2 27
PU JAPAN ENDOCRINE SOC
PI KYOTO
PA 75  YANAGINOBANBA NISHIIRU-MASUYA-CHO, SANJOU-DORI, NAKAGYOU-KU, KYOTO,
   604-8111, JAPAN
SN 0918-8959
EI 1348-4540
J9 ENDOCR J
JI Endocr. J.
PY 2019
VL 66
IS 10
BP 859
EP 870
DI 10.1507/endocrj.EJ18-0567
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA JQ7TX
UT WOS:000499144200003
PM 31270279
OA gold
DA 2023-06-08
ER

PT J
AU Dong, TS
   Chang, HH
   Hauer, M
   Lagishetty, V
   Katzka, W
   Rozengurt, E
   Jacobs, JP
   Eibl, G
AF Dong, Tien S.
   Chang, Hui-Hua
   Hauer, Meg
   Lagishetty, Venu
   Katzka, William
   Rozengurt, Enrique
   Jacobs, Jonathan P.
   Eibl, Guido
TI Metformin alters the duodenal microbiome and decreases the incidence of
   pancreatic ductal adenocarcinoma promoted by diet-induced obesity
SO AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
LA English
DT Article
DE clostridium; metformin; microbiome; obesity; pancreatic ductal
   adenocarcinoma; type 2 diabetes mellitus
ID INTRAEPITHELIAL NEOPLASIA; GUT MICROBIOME; REDUCED RISK; CANCER; IMPACT;
   LIVER
AB Pancreatic ductal adenocarcinoma (PDAC)'s growing incidence has been linked to the rise in obesity and type 2 diabetes mellitus. In previous work, we have shown that metformin can prevent the increased incidence of PDAC in a Kras(G12D) mouse model subjected to a diet high in fat and calories (HFCD). One potential way that metformin can affect the host is through alterations in the gut microbiome. Therefore, we investigated microbial associations with PDAC development and metformin use in the same mouse model. Lox-Stop-Lox Kras G12D/+ (LSL-Kras G12D/+); p48-Cre (KC) mice were given control diet, HFCD, or HFCD with 5 mg/mL metformin in drinking water for 3 mo. At the end of the 3 mo, 16S rRNA sequencing was performed to characterize microbiome composition of duodenal mucosal, duodenal luminal, and cecal luminal samples. KC mice on an HFCD demonstrated depletion of intact acini and formation of advanced pancreatic intraepithelial neoplasia. This effect was completely abrogated by metformin treatment. HFCD was associated with significant changes in microbial composition and diversity in the duodenal mucosa and lumen, much of which was prevented by metformin. In particular, Clostridium sensu stricto was negatively correlated with percent intact acini and seemed to be inhibited by the addition of metformin while on an HFCD. Administration of metformin eliminated PDAC formation in KC mice. This change was associated with significant microbial changes in both the mucosal and luminal microbiome of the duodenum. This suggests that the microbiome may be a potential mediator of the chemopreventive effects of metformin.
   NEW & NOTEWORTHY Pancreatic ductal adenocarcinoma (PDAC)'s growing incidence has been linked to the rise in obesity and type 2 diabetes mellitus. Administration of metformin eliminated PDAC formation in KC mice with diet-induced obesity. This change was associated with significant microbial changes in both the mucosal and luminal microbiome of the duodenum. This suggests that the microbiome may be a potential mediator of the chemopreventive effects of metformin.
C1 [Dong, Tien S.; Hauer, Meg; Lagishetty, Venu; Katzka, William; Rozengurt, Enrique; Jacobs, Jonathan P.] Univ Calif Los Angeles, Dept Med, Vatche & Tamar Manoukian Div Digest Dis, David Geffen Sch Med, Los Angeles, CA 90095 USA.
   [Chang, Hui-Hua; Hauer, Meg; Lagishetty, Venu; Katzka, William; Rozengurt, Enrique; Jacobs, Jonathan P.; Eibl, Guido] Univ Calif Los Angeles, CURE Digest Dis Res Ctr, David Geffen Sch Med, Los Angeles, CA 90095 USA.
   [Chang, Hui-Hua; Eibl, Guido] Univ Calif Los Angeles, Dept Surg, David Geffen Sch Med, Los Angeles, CA 90095 USA.
   [Hauer, Meg; Lagishetty, Venu; Katzka, William; Jacobs, Jonathan P.] Univ Calif Los Angeles, Microbiome Ctr, David Geffen Sch Med, Los Angeles, CA 90095 USA.
   [Rozengurt, Enrique; Jacobs, Jonathan P.] Vet Affairs Greater Los Angeles Healthcare Syst, Div Gastroenterol Hepatol & Parenteral Nutr, Los Angeles, CA USA.
C3 University of California System; University of California Los Angeles;
   University of California Los Angeles Medical Center; David Geffen School
   of Medicine at UCLA; University of California System; University of
   California Los Angeles; University of California Los Angeles Medical
   Center; David Geffen School of Medicine at UCLA; University of
   California System; University of California Los Angeles; University of
   California Los Angeles Medical Center; David Geffen School of Medicine
   at UCLA; University of California System; University of California Los
   Angeles; University of California Los Angeles Medical Center; David
   Geffen School of Medicine at UCLA; US Department of Veterans Affairs;
   Veterans Health Administration (VHA); VA Greater Los Angeles Healthcare
   System
RP Eibl, G (通讯作者)，Univ Calif Los Angeles, Dept Surg, David Geffen Sch Med, Los Angeles, CA 90095 USA.
EM GEibl@mednet.ucla.edu
RI Lagishetty, Venu/C-8251-2009
OI Lagishetty, Venu/0000-0001-6500-8255; Jacobs,
   Jonathan/0000-0003-4698-0254
FU National Institutes of Health (NIH) [P01-CA-163200]; NIH [R01-DK-100405,
   P30-DK-41301, P01CA-163200]; Department of Veterans Affair Merit Award
   [1I01BX001473]; Hirshberg Foundation for Pancreatic Cancer Research;
   NIH/National Institute of Diabetes and Digestive and Kidney Diseases
   [T32-DK-07180]; VA Career Development Award [IK2CX001717]
FX National Institutes of Health (NIH) Grant P01-CA-163200 supported the
   work of the laboratory of G. Eibl. The work in the laboratory of E.
   Rozengur was supported by NIH Grants R01-DK-100405, P30-DK-41301, and
   P01CA-163200 and by the Department of Veterans Affair Merit Award
   1I01BX001473. Additional funding for E. Rozengur and G. Eibl's
   laboratories came from the Hirshberg Foundation for Pancreatic Cancer
   Research. T. S. Dong was supported by NIH/National Institute of Diabetes
   and Digestive and Kidney Diseases T32-DK-07180, and J.P.J. was supported
   by VA Career Development Award IK2CX001717.
CR Anderson MJ, 2001, AUSTRAL ECOL, V26, P32, DOI 10.1046/j.1442-9993.2001.01070.x
   [Anonymous], CANC FACTS FIG 2019
   Bauer PV, 2018, CELL METAB, V27, P101, DOI 10.1016/j.cmet.2017.09.019
   Biankin AV, 2004, AM J SURG PATHOL, V28, P1184, DOI 10.1097/01.pas.0000131556.22382.3c
   Bracci PM, 2012, MOL CARCINOGEN, V51, P53, DOI 10.1002/mc.20778
   Broadhurst PJ, 2018, DIGEST DIS SCI, V63, P2840, DOI 10.1007/s10620-018-5233-y
   Call L, 2018, MICROBIOME, V6, DOI 10.1186/s40168-018-0498-0
   Callahan Ben J, 2016, F1000Res, V5, P1492
   Callahan BJ, 2016, NAT METHODS, V13, P581, DOI [10.1038/NMETH.3869, 10.1038/nmeth.3869]
   Caporaso JG, 2010, NAT METHODS, V7, P335, DOI 10.1038/nmeth.f.303
   Carding Simon, 2015, Microbial Ecology in Health and Disease, V26, P26191, DOI 10.3402/mehd.v26.26191
   Chang HH, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-24337-8
   Chang HH, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0184455
   Chari ST, 2005, GASTROENTEROLOGY, V129, P504, DOI 10.1053/j.gastro.2005.05.007
   Dawson DW, 2013, CANCER PREV RES, V6, P1064, DOI 10.1158/1940-6207.CAPR-13-0065
   Dong TS, 2019, CLIN GASTROENTEROL H, V17, P231, DOI 10.1016/j.cgh.2018.08.067
   Evans JMM, 2005, BMJ-BRIT MED J, V330, P1304, DOI 10.1136/bmj.38415.708634.F7
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Geller LT, 2017, SCIENCE, V357, P1156, DOI 10.1126/science.aah5043
   Goodrich JK, 2014, CELL, V158, P250, DOI 10.1016/j.cell.2014.06.037
   Hingorani SR, 2003, CANCER CELL, V4, P437, DOI 10.1016/S1535-6108(03)00309-X
   Hruban RH, 2007, MODERN PATHOL, V20, pS61, DOI 10.1038/modpathol.3800685
   Hruban RH, 2001, AM J SURG PATHOL, V25, P579, DOI 10.1097/00000478-200105000-00003
   Huxley R, 2005, BRIT J CANCER, V92, P2076, DOI 10.1038/sj.bjc.6602619
   Jacobs JP, 2017, GUT MICROBES, V8, P1, DOI 10.1080/19490976.2016.1257469
   Kim HJ, 2018, MEDICINE, V97, DOI 10.1097/MD.0000000000010036
   Kisfalvi K, 2013, PANCREAS, V42, P781, DOI 10.1097/MPA.0b013e31827aec40
   Kisfalvi K, 2009, CANCER RES, V69, P6539, DOI 10.1158/0008-5472.CAN-09-0418
   Lee DY, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-27965-2
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Li XG, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-06207-x
   Lozupone CA, 2008, FEMS MICROBIOL REV, V32, P557, DOI 10.1111/j.1574-6976.2008.00111.x
   Maruvada P, 2017, CELL HOST MICROBE, V22, P589, DOI 10.1016/j.chom.2017.10.005
   Ming M, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0114573
   Nadkarni MA, 2002, MICROBIOL-SGM, V148, P257, DOI 10.1099/00221287-148-1-257
   Nagathihalli NS, 2014, CANCER RES, V74, P2062, DOI 10.1158/0008-5472.CAN-13-2329
   Parekh PJ, 2015, CLIN TRANSL GASTROEN, V6, DOI 10.1038/ctg.2015.16
   Preheim SP, 2013, METHOD ENZYMOL, V531, P353, DOI 10.1016/B978-0-12-407863-5.00018-6
   Pushalkar S, 2018, CANCER DISCOV, V8, P403, DOI 10.1158/2159-8290.CD-17-1134
   Rahib L, 2014, CANCER RES, V74, P2913, DOI 10.1158/0008-5472.CAN-14-0155
   Romano-Keeler J, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0206366
   Sethi V, 2018, GASTROENTEROLOGY, V155, P33, DOI 10.1053/j.gastro.2018.04.001
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Sinnett-Smith J, 2013, BIOCHEM BIOPH RES CO, V430, P352, DOI 10.1016/j.bbrc.2012.11.010
   Smyth GK, 2004, STAT APPL GENET MOL, V3, DOI DOI 10.2202/1544-6115.1027
   Soares HP, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0057289
   Storey JD, 2003, P NATL ACAD SCI USA, V100, P9440, DOI 10.1073/pnas.1530509100
   Tong Maomeng, 2014, Curr Protoc Immunol, V107, DOI 10.1002/0471142735.im0741s107
   Tseng CH, 2018, PANCREAS, V47, pE57, DOI 10.1097/MPA.0000000000001130
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Udaondo Z, 2017, ENVIRON MICROBIOL, V19, P2588, DOI 10.1111/1462-2920.13732
   Wan GX, 2018, CELL PHYSIOL BIOCHEM, V49, P837, DOI 10.1159/000493214
   Wang Z, 2014, DIABETES RES CLIN PR, V106, P19, DOI 10.1016/j.diabres.2014.04.007
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Xue LX, 1996, JNCI-J NATL CANCER I, V88, P1586, DOI 10.1093/jnci/88.21.1586
   Yoshimoto S, 2013, NATURE, V499, P97, DOI 10.1038/nature12347
   Zhou PT, 2017, ONCOTARGET, V8, P25242, DOI 10.18632/oncotarget.15692
NR 57
TC 20
Z9 20
U1 1
U2 20
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0193-1857
EI 1522-1547
J9 AM J PHYSIOL-GASTR L
JI Am. J. Physiol.-Gastroint. Liver Physiol.
PD DEC
PY 2019
VL 317
IS 6
BP G763
EP G772
DI 10.1152/ajpgi.00170.2019
PG 10
WC Gastroenterology & Hepatology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Physiology
GA JQ1BP
UT WOS:000498689000002
PM 31545922
OA Green Published
DA 2023-06-08
ER

PT J
AU Ma, XY
   Xiao, WC
   Li, H
   Pang, P
   Xue, FX
   Wan, L
   Pei, L
   Yan, HH
AF Ma, Xiaoyi
   Xiao, Wenchang
   Li, Hao
   Pang, Pei
   Xue, Feixiao
   Wan, Lu
   Pei, Lei
   Yan, Huanhuan
TI Metformin restores hippocampal neurogenesis and learning and memory via
   regulating gut microbiota in the obese mouse model
SO BRAIN BEHAVIOR AND IMMUNITY
LA English
DT Article
DE Obesity; Hippocampal neurogenesis; Learning and memory; Metformin; Gut
   microbiota
ID ADULT NEUROGENESIS; SPATIAL MEMORY; DIET; NEUROINFLAMMATION; MICROGLIA;
   RISK; CELL
AB Numerous studies have shown that over-nutritional obesity may lead to pre-diabetes, type 2 diabetes and cognitive decline. As the degree of metabolic disorders increases, the cognitive decline is getting worse. However, the cellular events that cause this cognitive dysfunction is yet to be clarified. We used a high-fat diet (HFD) consumption-induced obesity mouse model to test the effects of metformin on the hippocampal neurogenesis and learning and memory abilities of obese mice. 5-Bromo-2 '-deoxyuridine (BrdU) labelling and retrovirus labeling were applied to detect hippocampal newborn neurons. Behavioral experiments were used to detect learning and memory abilities of mice. 16S rRNA gene sequencing was performed to detect the composition of gut microbiota. The positron emission tomography (PET) was conducted to detect the energy metabolism activity of different mouse brain regions. Our results reveal that metformin restores the impairment of neurogenesis in the dentate gyrus and finally prevents the cognitive decline of the obese mice. Moreover, the therapeutic effects of metformin are achieved by regulating the composition of gut microbiota of mice, which may inhibit microglia activation and neuroinflammation in the brain of obese mice. This study suggests that metformin may be taken as a promising candidate for the intervention of cognitive decline related to imbalance of gut microbiota caused by obesity.
C1 [Ma, Xiaoyi] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Endocrinol, Guangzhou 510080, Peoples R China.
   [Xiao, Wenchang; Wan, Lu; Yan, Huanhuan] Huazhong Univ Sci & Technol HUST, Coll Life Sci & Technol, Dept Biomed Engn, Wuhan 430074, Peoples R China.
   [Li, Hao; Pang, Pei; Pei, Lei; Yan, Huanhuan] Huazhong Univ Sci & Technol, Collaborat Innovat Ctr Brain Sci, Inst Brain Res, Wuhan 430030, Peoples R China.
   [Pang, Pei] Soochow Univ, Affiliated Hosp 1, Dept Pathol, Suzhou 215000, Peoples R China.
   [Xue, Feixiao] Xian No 3 Hosp, Dept Lab, Xian 710018, Peoples R China.
   [Pei, Lei] Huazhong Univ Sci & Technol, Sch Basic Med, Dept Neurobiol, Wuhan 430030, Peoples R China.
   [Pei, Lei] Huazhong Univ Sci & Technol, Tongji Med Coll, Wuhan 430030, Peoples R China.
   [Pei, Lei] Washington Univ, Sch Med, Dept Anesthesiol, St Louis, MO 63110 USA.
C3 Sun Yat Sen University; Huazhong University of Science & Technology;
   Huazhong University of Science & Technology; Soochow University - China;
   Huazhong University of Science & Technology; Huazhong University of
   Science & Technology; Washington University (WUSTL)
RP Yan, HH (通讯作者)，Huazhong Univ Sci & Technol HUST, Coll Life Sci & Technol, Dept Biomed Engn, Wuhan 430074, Peoples R China.; Pei, L (通讯作者)，Huazhong Univ Sci & Technol, Sch Basic Med, Dept Neurobiol, Wuhan 430030, Peoples R China.; Pei, L (通讯作者)，Huazhong Univ Sci & Technol, Tongji Med Coll, Wuhan 430030, Peoples R China.
EM peilei@hust.edu.cn; yanhh0511@foxmail.com
RI Ma, Xiaoyi/HJH-6205-2023
OI Xiao, Wenchang/0000-0002-7256-4871
FU National Natural Science Foundation of China [81901304, 81870932]; China
   Postdoctoral Science Foundation [2019 T120663, 2018 M640704]; 2018 Key
   Laboratory Fund of Research Department [02.03.2018102]; Shaanxi
   Provincial Key research and development Program [2018SF-090]
FX The authors greatly thank Prof. Qingguo Xie and Chuying Lei (HUST) for
   PET technological assistant. This work was supported by the National
   Natural Science Foundation of China (81901304 HY, 81870932 LP) , China
   Postdoctoral Science Foundation (2019 T120663 HY, 2018 M640704 HY) ,
   2018 Key Laboratory Fund of Research Department (02.03.2018102 HY) and
   the Shaanxi Provincial Key research and development Program (2018SF-090
   FX) .
CR Appel JR, 2018, J NEUROSCI, V38, P5949, DOI 10.1523/JNEUROSCI.3621-17.2018
   Bailey CJ, 2017, DIABETOLOGIA, V60, P1566, DOI 10.1007/s00125-017-4318-z
   Banks WA, 1995, NEUROIMMUNOMODULAT, V2, P241, DOI 10.1159/000097202
   Brandhorst S, 2015, CELL METAB, V22, P86, DOI 10.1016/j.cmet.2015.05.012
   Bruce-Keller AJ, 2015, BIOL PSYCHIAT, V77, P607, DOI 10.1016/j.biopsych.2014.07.012
   Cai DS, 2013, TRENDS ENDOCRIN MET, V24, P40, DOI 10.1016/j.tem.2012.11.003
   Cheng G, 2012, INTERN MED J, V42, P484, DOI 10.1111/j.1445-5994.2012.02758.x
   Clapp M, 2017, CLINICS PRACT, V7, P131, DOI 10.4081/cp.2017.987
   Coppin G., 2014, NEUROPSYCHOLOGIA, V65146-55
   Cryan JF, 2019, PHYSIOL REV, V99, P1877, DOI 10.1152/physrev.00018.2018
   DeFronzo RA, 1999, ANN INTERN MED, V131, P281, DOI 10.7326/0003-4819-131-4-199908170-00008
   Deng H., 2020, FRONT PHARMACOL, V11432
   Dilger RN, 2008, J LEUKOCYTE BIOL, V84, P932, DOI 10.1189/jlb.0208108
   Elmore MRP, 2014, NEURON, V82, P380, DOI 10.1016/j.neuron.2014.02.040
   Erny D, 2015, NAT NEUROSCI, V18, P965, DOI 10.1038/nn.4030
   Fernandez-Real JM, 2015, J CLIN ENDOCR METAB, V100, P4505, DOI 10.1210/jc.2015-3076
   Frasca D., 2017, FRONT IMMUNOL, V81745
   Gage FH, 2013, NEURON, V80, P588, DOI 10.1016/j.neuron.2013.10.037
   Guillemot-Legris O, 2017, TRENDS NEUROSCI, V40, P237, DOI 10.1016/j.tins.2017.02.005
   He L, 2015, CELL METAB, V21, P159, DOI 10.1016/j.cmet.2015.01.003
   Hitti FL, 2014, NATURE, V508, P88, DOI 10.1038/nature13028
   Imfeld P, 2012, J AM GERIATR SOC, V60, P916, DOI 10.1111/j.1532-5415.2012.03916.x
   Jiang CM, 2017, J ALZHEIMERS DIS, V58, P1, DOI 10.3233/JAD-161141
   Jin HJ, 2016, MOL NEUROBIOL, V53, P851, DOI 10.1007/s12035-014-9045-6
   Johnson DH, 2012, J MAGN RESON IMAGING, V35, P837, DOI 10.1002/jmri.23508
   Lee H, 2018, GUT MICROBES, V9, P155, DOI 10.1080/19490976.2017.1405209
   Lee JH, 2014, ENDOCRINOL METAB, V29, P112, DOI 10.3803/EnM.2014.29.2.112
   Leon-Coria A, 2018, PLOS PATHOG, V14, DOI 10.1371/journal.ppat.1007466
   Li GL, 2017, CELL METAB, V26, P672, DOI 10.1016/j.cmet.2017.08.019
   Martinez-Lapiscina EH, 2013, J NEUROL NEUROSUR PS, V84, P1318, DOI 10.1136/jnnp-2012-304792
   Matulewicz N, 2016, POSTEP HIG MED DOSW, V70, P1245
   McNeilly AD, 2012, DIABETOLOGIA, V55, P3061, DOI 10.1007/s00125-012-2686-y
   Melo H.M., 2019, FRONT NEUROSCI-SWITZ, V13265
   Ming GL, 2011, NEURON, V70, P687, DOI 10.1016/j.neuron.2011.05.001
   Ogbonnaya ES, 2015, BIOL PSYCHIAT, V78, pE7, DOI 10.1016/j.biopsych.2014.12.023
   Ogrodnik M, 2019, CELL METAB, V29, P1061, DOI [10.1016/j.cmet.2018.12.008, 10.1016/j.cmet.2019.01.013]
   Park HR, 2010, NEUROSCI LETT, V482, P235, DOI 10.1016/j.neulet.2010.07.046
   Pascale A., 2019, CURR OPIN PHARMACOL, P491
   Pintana H, 2012, LIFE SCI, V91, P409, DOI 10.1016/j.lfs.2012.08.017
   Potts MB, 2012, CELL STEM CELL, V11, P5, DOI 10.1016/j.stem.2012.06.003
   Sampson TR, 2016, CELL, V167, P1469, DOI 10.1016/j.cell.2016.11.018
   Santarelli L, 2003, SCIENCE, V301, P805, DOI 10.1126/science.1083328
   Sharon G, 2019, CELL, V177, P1600, DOI 10.1016/j.cell.2019.05.004
   Soto M, 2018, MOL PSYCHIATR, V23, P2287, DOI 10.1038/s41380-018-0086-5
   Sun MF, 2018, BRAIN BEHAV IMMUN, V70, P48, DOI 10.1016/j.bbi.2018.02.005
   Tanokashira D, 2018, FEBS OPEN BIO, V8, P1104, DOI 10.1002/2211-5463.12436
   Tarantini S, 2018, J GERONTOL A-BIOL, V73, P853, DOI 10.1093/gerona/glx177
   Thangthaeng N, 2017, AGING DIS, V8, P17, DOI 10.14336/AD.2016.1010
   Toni N, 2008, NAT NEUROSCI, V11, P901, DOI 10.1038/nn.2156
   Upadhyay J, 2018, MED CLIN N AM, V102, P13, DOI 10.1016/j.mcna.2017.08.004
   Valcarcel-Ares MN, 2019, J GERONTOL A-BIOL, V74, P290, DOI 10.1093/gerona/gly127
   Valero J, 2017, J ALZHEIMERS DIS, V60, pS161, DOI 10.3233/JAD-170239
   Windarti N., 2019, PUBLIC HEALTH, P16926
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
NR 54
TC 24
Z9 24
U1 2
U2 28
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0889-1591
EI 1090-2139
J9 BRAIN BEHAV IMMUN
JI Brain Behav. Immun.
PD JUL
PY 2021
VL 95
BP 68
EP 83
DI 10.1016/j.bbi.2021.02.011
EA JUN 2021
PG 16
WC Immunology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Immunology; Neurosciences & Neurology; Psychiatry
GA SN8CA
UT WOS:000658513000014
PM 33609653
DA 2023-06-08
ER

PT J
AU Zhang, SY
   Lam, TKT
AF Zhang, Song-Yang
   Lam, Tony K. T.
TI Metabolic regulation by the intestinal metformin-AMPK axis
SO NATURE COMMUNICATIONS
LA English
DT Article
ID ACTIVATED PROTEIN-KINASE
AB AMP-activated protein kinase (AMPK) mediates the glucose-lowering effect of the antidiabetic agent metformin, but the sites of action remain unclear. In the March issue of Nature Communications, Zhang and colleagues reported that intestinal epithelium-specific AMPK alpha 1 knockout mice fail to respond to metformin and exhibit disruption in metabolic homeostasis secondary to changes in the gut microbiome. This highlights a therapeutic potential of targeting intestinal AMPK for diabetes.
C1 [Zhang, Song-Yang; Lam, Tony K. T.] UHN, Toronto Gen Hosp Res Inst, Toronto, ON, Canada.
   [Lam, Tony K. T.] Univ Toronto, Dept Physiol, Toronto, ON, Canada.
   [Lam, Tony K. T.] Univ Toronto, Dept Med, Toronto, ON, Canada.
   [Lam, Tony K. T.] Univ Toronto, Banting & Best Diabet Ctr, Toronto, ON, Canada.
C3 University of Toronto; University Health Network Toronto; University of
   Toronto; University of Toronto; University of Toronto
RP Lam, TKT (通讯作者)，UHN, Toronto Gen Hosp Res Inst, Toronto, ON, Canada.; Lam, TKT (通讯作者)，Univ Toronto, Dept Physiol, Toronto, ON, Canada.; Lam, TKT (通讯作者)，Univ Toronto, Dept Med, Toronto, ON, Canada.; Lam, TKT (通讯作者)，Univ Toronto, Banting & Best Diabet Ctr, Toronto, ON, Canada.
EM tony.lam@uhnresearch.ca
OI Lam, Tony/0000-0003-2908-3324
FU Canadian Institutes of Health Research (CIHR); CIHR Foundation
   [FDN-143204]; Endowed Chair in Diabetes Research & the Tier 1 Canada
   Research Chair in Diabetes and Obesity at the Toronto General Hospital
   Research Institute; University of Toronto
FX S.-Y. Z. is supported by a Canadian Institutes of Health Research (CIHR)
   post-doctoral fellowship. T.K.T.L. is supported by a CIHR Foundation
   Grant (FDN-143204) and holds the John Kitson McIvor (1915-1942) Endowed
   Chair in Diabetes Research & the Tier 1 Canada Research Chair in
   Diabetes and Obesity at the Toronto General Hospital Research Institute
   and the University of Toronto.
CR Bauer PV, 2018, CELL METAB, V27, P101, DOI 10.1016/j.cmet.2017.09.019
   Borg MJ, 2019, DIABETES OBES METAB, V21, P640, DOI 10.1111/dom.13567
   Buse JB, 2016, DIABETES CARE, V39, P198, DOI 10.2337/dc15-0488
   Cherney DZI, 2018, CELL METAB, V28, P808, DOI 10.1016/j.cmet.2018.11.012
   Duca FA, 2021, NAT COMMUN, V12, DOI 10.1038/s41467-021-21235-y
   Duca FA, 2015, NAT MED, V21, P506, DOI 10.1038/nm.3787
   Miller RA, 2013, NATURE, V494, P256, DOI 10.1038/nature11808
   Olivier S, 2021, MOL METAB, V47, DOI 10.1016/j.molmet.2021.101183
   Stepensky D, 2002, DRUG METAB DISPOS, V30, P861, DOI 10.1124/dmd.30.8.861
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Waise TMZ, 2021, MOL METAB, V44, DOI 10.1016/j.molmet.2020.101132
   Waise TMZ, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-08582-7
   Wang Y, 2019, CELL REP, V29, P1511, DOI 10.1016/j.celrep.2019.09.070
   Zhang E., 2022, NAT COMMUN, V13, P110
   Zhou GC, 2001, J CLIN INVEST, V108, P1167, DOI 10.1172/JCI200113505
NR 15
TC 0
Z9 0
U1 0
U2 8
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
EI 2041-1723
J9 NAT COMMUN
JI Nat. Commun.
PD MAY 23
PY 2022
VL 13
IS 1
AR 2851
DI 10.1038/s41467-022-30477-3
PG 3
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 1Q5AE
UT WOS:000802699200019
PM 35606343
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Rosario, D
   Benfeitas, R
   Bidkhori, G
   Zhang, C
   Uhlen, M
   Shoaie, S
   Mardinoglu, A
AF Rosario, Dorines
   Benfeitas, Rui
   Bidkhori, Gholamreza
   Zhang, Cheng
   Uhlen, Mathias
   Shoaie, Saeed
   Mardinoglu, Adil
TI Understanding the Representative Gut Microbiota Dysbiosis in
   Metformin-Treated Type 2 Diabetes Patients Using Genome-Scale Metabolic
   Modeling
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Article
DE gut microbiota; dysbiosis; host-microbiome interactions; genome-scale
   metabolic models; systems biology
ID ESCHERICHIA-COLI; AKKERMANSIA-MUCINIPHILA; SYNTHETIC LETHALITY;
   AROMATIC-COMPOUNDS; NETWORK; RECONSTRUCTION; GENERATION; METAGENOME;
   REDUCTION; BACTERIA
AB Dysbiosis in the gut microbiome composition may be promoted by therapeutic drugs such as metformin, the world's most prescribed antidiabetic drug. Under metformin treatment, disturbances of the intestinal microbes lead to increased abundance of Escherichia spp., Akkermansia muciniphila, Subdoligranulum variabile and decreased abundance of Intestinibacter bartlettii. This alteration may potentially lead to adverse effects on the host metabolism, with the depletion of butyrate producer genus. However, an increased production of butyrate and propionate was verified in metformin-treated Type 2 diabetes (T2D) patients. The mechanisms underlying these nutritional alterations and their relation with gut microbiota dysbiosis remain unclear. Here, we used Genomescale Metabolic Models of the representative gut bacteria Escherichia spp., I. bartlettii, A. muciniphila, and S. variabile to elucidate their bacterial metabolism and its effect on intestinal nutrient pool, including macronutrients (e.g., amino acids and short chain fatty acids), minerals and chemical elements (e.g., iron and oxygen). We applied flux balance analysis (FBA) coupled with synthetic lethality analysis interactions to identify combinations of reactions and extracellular nutrients whose absence prevents growth. Our analyses suggest that Escherichia sp. is the bacteria least vulnerable to nutrient availability. We have also examined bacterial contribution to extracellular nutrients including short chain fatty acids, amino acids, and gasses. For instance, Escherichia sp. and S. variabile may contribute to the production of important short chain fatty acids (e.g., acetate and butyrate, respectively) involved in the host physiology under aerobic and anaerobic conditions. We have also identified pathway susceptibility to nutrient availability and reaction changes among the four bacteria using both FBA and flux variability analysis. For instance, lipopolysaccharide synthesis, nucleotide sugar metabolism, and amino acid metabolism are pathways susceptible to changes in Escherichia sp. and A. muciniphila. Our observations highlight important commensal and competing behavior, and their association with cellular metabolism for prevalent gut microbes. The results of our analysis have potential important implications for development of new therapeutic approaches in T2D patients through the development of prebiotics, probiotics, or postbiotics.
C1 [Rosario, Dorines; Benfeitas, Rui; Bidkhori, Gholamreza; Zhang, Cheng; Uhlen, Mathias; Mardinoglu, Adil] Royal Inst Technol, Sci Life Lab, Stockholm, Sweden.
   [Shoaie, Saeed] Kings Coll London, Ctr Host Microbiome Interact, Dent Inst, London, England.
   [Shoaie, Saeed] Karolinska Inst, Ctr Translat Microbiome Res, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden.
   [Mardinoglu, Adil] Chalmers Univ Technol, Dept Biol & Biol Engn, Gothenburg, Sweden.
C3 Royal Institute of Technology; University of London; King's College
   London; Karolinska Institutet; Chalmers University of Technology
RP Mardinoglu, A (通讯作者)，Royal Inst Technol, Sci Life Lab, Stockholm, Sweden.; Shoaie, S (通讯作者)，Kings Coll London, Ctr Host Microbiome Interact, Dent Inst, London, England.; Shoaie, S (通讯作者)，Karolinska Inst, Ctr Translat Microbiome Res, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden.; Mardinoglu, A (通讯作者)，Chalmers Univ Technol, Dept Biol & Biol Engn, Gothenburg, Sweden.
EM saeed.shoaie@kcl.ac.uk; adilm@scilifelab.se
RI Uhlen, Mathias/AAV-8746-2021; Benfeitas, Rui/G-1251-2016; Uhlen,
   Mathias/HPB-8445-2023; Uhlen, Mathias/B-3262-2016; Zhang,
   Cheng/L-7906-2016; Mardinoglu, Adil/AAS-6360-2021
OI Benfeitas, Rui/0000-0001-7972-0083; Uhlen, Mathias/0000-0002-4858-8056;
   Uhlen, Mathias/0000-0002-4858-8056; Zhang, Cheng/0000-0002-3721-8586;
   Shoaie, Saeed/0000-0001-5834-4533
FU Knut and Alice Wallenberg Foundation; King's College London
FX This work was funded by Knut and Alice Wallenberg Foundation and King's
   College London.
CR Agren R, 2013, PLOS COMPUT BIOL, V9, DOI 10.1371/journal.pcbi.1002980
   Al Khodor S, 2017, FRONT PEDIATR, V5, DOI 10.3389/fped.2017.00138
   Baek JM, 2013, BIOTECHNOL BIOENG, V110, P2790, DOI 10.1002/bit.24925
   Benfeitas R, 2017, FRONT CELL DEV BIOL, V5, DOI 10.3389/fcell.2017.00065
   Berrios-Rivera SJ, 2002, METAB ENG, V4, P230, DOI 10.1006/mben.2002.0228
   Braun V, 2002, FEBS LETT, V529, P78, DOI 10.1016/S0014-5793(02)03185-X
   Brillat-Savarin A., 1826, PHYSL GOUT, V32, P243, DOI [10.1002/cind.786-16.x, DOI 10.1002/CIND.786-16.X]
   Bueno E, 2012, ANTIOXID REDOX SIGN, V16, P819, DOI 10.1089/ars.2011.4051
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Derrien M, 2004, INT J SYST EVOL MICR, V54, P1469, DOI 10.1099/ijs.0.02873-0
   Diaz E, 2001, MICROBIOL MOL BIOL R, V65, P523, DOI 10.1128/MMBR.65.4.523-569.2001
   Donaldson GP, 2016, NAT REV MICROBIOL, V14, P20, DOI 10.1038/nrmicro3552
   Edwards JS, 2001, NAT BIOTECHNOL, V19, P125, DOI 10.1038/84379
   Eker S, 2013, BMC BIOINFORMATICS, V14, DOI 10.1186/1471-2105-14-114
   Feist AM, 2007, MOL SYST BIOL, V3, DOI 10.1038/msb4100155
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Fuchs G, 2011, NAT REV MICROBIOL, V9, P803, DOI 10.1038/nrmicro2652
   Henry CS, 2010, NAT BIOTECHNOL, V28, P977, DOI 10.1038/nbt.1672
   Hyotylainen T, 2016, NAT COMMUN, V7, DOI 10.1038/ncomms9994
   Imielinski M, 2006, BIOPHYS J, V90, P2659, DOI 10.1529/biophysj.105.069278
   Jahng J, 2012, NEUROGASTROENT MOTIL, V24, P185, DOI 10.1111/j.1365-2982.2011.01819.x
   Ji BY, 2015, FRONT GENET, V6, DOI 10.3389/fgene.2015.00219
   Kaelin WG, 2005, NAT REV CANCER, V5, P689, DOI 10.1038/nrc1691
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Keseler IM, 2013, NUCLEIC ACIDS RES, V41, pD605, DOI 10.1093/nar/gks1027
   KOPPENOL WH, 1993, FREE RADICAL BIO MED, V15, P645, DOI 10.1016/0891-5849(93)90168-T
   Lee S, 2018, NUCLEIC ACIDS RES, V46, pD595, DOI 10.1093/nar/gkx994
   Lee S, 2017, MOL SYST BIOL, V13, DOI 10.15252/msb.20177703
   Lewis S, 2007, AM J GASTROENTEROL, V102, P624, DOI 10.1111/j.1572-0241.2006.01020.x
   Louis P, 2009, FEMS MICROBIOL LETT, V294, P1, DOI 10.1111/j.1574-6968.2009.01514.x
   LOVLEY DR, 1986, APPL ENVIRON MICROB, V51, P683, DOI 10.1128/AEM.51.4.683-689.1986
   Magnusdottir S, 2017, NAT BIOTECHNOL, V35, P81, DOI 10.1038/nbt.3703
   Mardinoglu A, 2012, J INTERN MED, V271, P142, DOI 10.1111/j.1365-2796.2011.02493.x
   Mardinoglu A, 2018, NAT REV GASTRO HEPAT, V15, P365, DOI 10.1038/s41575-018-0007-8
   Mardinoglu A, 2016, CELL METAB, V23, P10, DOI 10.1016/j.cmet.2015.12.012
   Mardinoglu A, 2015, MOL SYST BIOL, V11, DOI 10.15252/msb.20156487
   Moreno-Vivian C, 1999, J BACTERIOL, V181, P6573
   O'Neil NJ, 2017, NAT REV GENET, V18, P613, DOI 10.1038/nrg.2017.47
   Pratapa A, 2015, BIOINFORMATICS, V31, P3299, DOI 10.1093/bioinformatics/btv352
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Schellenberger J, 2011, NAT PROTOC, V6, P1290, DOI 10.1038/nprot.2011.308
   Shoaie S, 2015, CELL METAB, V22, P320, DOI 10.1016/j.cmet.2015.07.001
   Shoaie S, 2013, SCI REP-UK, V3, DOI 10.1038/srep02532
   Tremaroli V, 2012, NATURE, V489, P242, DOI 10.1038/nature11552
   Turanli B, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.00500
   Uhlen M, 2017, SCIENCE, V357, P660, DOI 10.1126/science.aan2507
   Varemo L, 2015, CELL REP, V11, P921, DOI 10.1016/j.celrep.2015.04.010
   Wattam AR, 2017, NUCLEIC ACIDS RES, V45, pD535, DOI 10.1093/nar/gkw1017
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Zhang C, 2016, FRONT PHYSIOL, V6, DOI 10.3389/fphys.2015.00413
NR 50
TC 46
Z9 50
U1 1
U2 29
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD JUN 25
PY 2018
VL 9
AR 775
DI 10.3389/fphys.2018.00775
PG 14
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA GK4TU
UT WOS:000436159000001
PM 29988585
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Xiong, Y
   Song, WT
   Shen, LM
   Wang, Y
   Zhang, J
   Hu, MY
   Liu, Y
   Li, JJ
   Musetti, S
   Liu, RH
   Huang, L
AF Xiong, Yang
   Song, Wantong
   Shen, Limei
   Wang, Ying
   Zhang, Jing
   Hu, Mengying
   Liu, Yun
   Li, Jingjing
   Musetti, Sara
   Liu, Rihe
   Huang, Leaf
TI Oral Metformin and Polymetformin Reprogram Immunosuppressive
   Microenvironment and Boost Immune Checkpoint Inhibitor Therapy in
   Colorectal Cancer
SO ADVANCED THERAPEUTICS
LA English
DT Article
DE cancer immunotherapy; immune checkpoint blockade; metformin;
   Polymetformin; tumor microenvironments
ID LACTIC-ACID BACTERIA; PD-L1 EXPRESSION; TUMOR-GROWTH;
   LACTOBACILLUS-ACIDOPHILUS; GASTRIC-CARCINOMA; GUT MICROBIOME;
   OVARIAN-CANCER; BLOCKADE; CELLS; ROLES
AB Immune checkpoint inhibitors (ICI), especially PD-1/PD-L1 inhibitors, are emerging as promising therapeutic options for patients with advanced tumors, but the response rate in the majority of colorectal cancer (CRC) patients remains low. Herein, the use of metformin (Met) and its polymeric form (Polymet) to enhance the response rate of immune checkpoint blockade therapy is reported. Oral Met and Polymet significantly enhance the antitumor effect of ICI therapy in a murine orthotopic CRC model. Further analyses reveal that Met and Polymet reprogram the immunosuppressive tumor microenvironment via activation of adenosine 5 '-monophosphate-activated protein kinase and inhibition of the mammalian target of rapamycin signaling pathway, stimulating T cell infiltration into the tumor. Additionally, oral Met and Polymet change the abundance of key microbes in the intestinal environment, including increasing theLactobacilluspopulation, which should exert tumor-suppressing activities in the CRC. These findings highlight the potential of combining Met or Polymet with cancer immunotherapy and provide a strategy for sensitizing CRC patients to immune checkpoint blockade therapy.
C1 [Xiong, Yang; Song, Wantong; Shen, Limei; Wang, Ying; Zhang, Jing; Hu, Mengying; Liu, Yun; Li, Jingjing; Musetti, Sara; Liu, Rihe; Huang, Leaf] Univ N Carolina, UNC Eshelman Sch Pharm, Chapel Hill, NC 27559 USA.
   [Xiong, Yang] Zhejiang Chinese Med Univ, Coll Pharmaceut Sci, Hangzhou 310053, Zhejiang, Peoples R China.
   [Song, Wantong] Chinese Acad Sci, Changchun Inst Appl Chem, Key Lab Polymer Ecomat, Changchun 130022, Jilin, Peoples R China.
C3 University of North Carolina; University of North Carolina Chapel Hill;
   Zhejiang Chinese Medical University; Chinese Academy of Sciences;
   Changchun Institute of Applied Chemistry, CAS
RP Huang, L (通讯作者)，Univ N Carolina, UNC Eshelman Sch Pharm, Chapel Hill, NC 27559 USA.
EM leafh@email.unc.edu
RI Hu, Mengying/ABB-8549-2020
OI Hu, Mengying/0000-0002-0358-6014
FU Carolina Center for Cancer Nanotechnology Excellence (NIH) [CA198999];
   National Natural Science Foundation of China [81774011]
FX This work was supported by the Carolina Center for Cancer Nanotechnology
   Excellence (NIH grant CA198999) and was also supported by project of the
   National Natural Science Foundation of China (No. 81774011).
CR Abiko K, 2013, CLIN CANCER RES, V19, P1363, DOI 10.1158/1078-0432.CCR-12-2199
   Baldassari S, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-22054-w
   Baldwin C, 2010, NUTR CANCER, V62, P371, DOI 10.1080/01635580903407197
   Bezu L, 2015, FRONT IMMUNOL, V6, DOI 10.3389/fimmu.2015.00187
   Bu LL, 2016, ONCOIMMUNOLOGY, V5, DOI 10.1080/2162402X.2015.1130206
   Cha JH, 2018, MOL CELL, V71, P606, DOI 10.1016/j.molcel.2018.07.030
   Chen CC, 2012, BRIT J NUTR, V107, P1623, DOI 10.1017/S0007114511004934
   Chen C, 2018, FOOD FUNCT, V9, P3732, DOI [10.1039/C7FO01346A, 10.1039/c7fo01346a]
   Chen Q, 2016, NAT COMMUN, V7, DOI 10.1038/ncomms13193
   De Velasco G, 2017, CANCER IMMUNOL RES, V5, P312, DOI 10.1158/2326-6066.CIR-16-0237
   Duan XP, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-09221-x
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Fujita M, 2011, CANCER RES, V71, P2664, DOI 10.1158/0008-5472.CAN-10-3055
   Gabrilovich D, 2003, CURR DRUG TARGETS, V4, P525, DOI 10.2174/1389450033490849
   Garrett WS, 2015, SCIENCE, V348, P80, DOI 10.1126/science.aaa4972
   Goodwin TJ, 2017, BIOMATERIALS, V141, P260, DOI 10.1016/j.biomaterials.2017.07.007
   Gopalakrishnan V, 2018, CANCER CELL, V33, P570, DOI 10.1016/j.ccell.2018.03.015
   Graham GG, 2011, CLIN PHARMACOKINET, V50, P81, DOI 10.2165/11534750-000000000-00000
   He CB, 2016, NAT COMMUN, V7, DOI 10.1038/ncomms12499
   Hu MY, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-10893-8
   Huber TB, 2011, KIDNEY INT, V79, P502, DOI 10.1038/ki.2010.457
   Johnson DB, 2017, CANCER-AM CANCER SOC, V123, P1904, DOI 10.1002/cncr.30642
   Kim ST, 2017, ONCOTARGET, V8, P77415, DOI 10.18632/oncotarget.20492
   Koller VJ, 2008, FOOD CHEM TOXICOL, V46, P1221, DOI 10.1016/j.fct.2007.09.005
   Kroemer G, 2013, ANNU REV IMMUNOL, V31, P51, DOI 10.1146/annurev-immunol-032712-100008
   Kuo CL, 2008, J CELL BIOCHEM, V103, P931, DOI 10.1002/jcb.21466
   Lasry A, 2016, NAT IMMUNOL, V17, P230, DOI 10.1038/ni.3384
   Le DT, 2015, NEW ENGL J MED, V372, P2509, DOI 10.1056/NEJMoa1500596
   Le DT, 2016, J CLIN ONCOL, V34, DOI 10.1200/JCO.2016.34.15_suppl.103
   Liu XR, 2020, MICROORGANISMS, V8, DOI 10.3390/microorganisms8020175
   Lopez-Fauqued M, 2010, INT J CANCER, V126, P1549, DOI 10.1002/ijc.24926
   Lu KD, 2016, J AM CHEM SOC, V138, P12502, DOI 10.1021/jacs.6b06663
   Marichal T, 2013, CANCER IMMUNOL RES, V1, P269, DOI 10.1158/2326-6066.CIR-13-0119
   Miao L, 2017, ACS NANO, V11, P8690, DOI 10.1021/acsnano.7b01786
   Miotto D, 2010, LUNG CANCER, V69, P355, DOI 10.1016/j.lungcan.2009.12.012
   Mo CF, 2014, ANTIOXID REDOX SIGN, V20, P574, DOI 10.1089/ars.2012.5116
   Moiseeva O, 2013, AGING CELL, V12, P489, DOI 10.1111/acel.12075
   Nishikawa H, 2014, CURR OPIN IMMUNOL, V27, P1, DOI 10.1016/j.coi.2013.12.005
   Ostrand-Rosenberg S, 2012, SEMIN CANCER BIOL, V22, P275, DOI 10.1016/j.semcancer.2012.01.011
   Pfirschke C, 2016, IMMUNITY, V44, P343, DOI 10.1016/j.immuni.2015.11.024
   Postow MA, 2015, J CLIN ONCOL, V33, P1974, DOI 10.1200/JCO.2014.59.4358
   Rabinovich GA, 2007, ANNU REV IMMUNOL, V25, P267, DOI 10.1146/annurev.immunol.25.022106.141609
   Rattan R, 2011, NEOPLASIA, V13, P483, DOI 10.1593/neo.11148
   Ribas A, 2018, SCIENCE, V359, P1350, DOI 10.1126/science.aar4060
   Saisho Y, 2015, ENDOCR METAB IMMUNE, V15, P196, DOI 10.2174/1871530315666150316124019
   Scharping NE, 2017, CANCER IMMUNOL RES, V5, P9, DOI 10.1158/2326-6066.CIR-16-0103
   Soliman H, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0088557
   Song WT, 2018, ADV MATER, V30, DOI 10.1002/adma.201805007
   Song WT, 2017, BIOMATERIALS, V148, P16, DOI 10.1016/j.biomaterials.2017.09.017
   Sun J, 2007, TISSUE ANTIGENS, V69, P19, DOI 10.1111/j.1399-0039.2006.00701.x
   Talmadge JE, 2013, NAT REV CANCER, V13, P739, DOI 10.1038/nrc3581
   Tiptiri-Kourpeti A, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0147960
   Topalian SL, 2012, CURR OPIN IMMUNOL, V24, P207, DOI 10.1016/j.coi.2011.12.009
   Vallianou NG, 2019, HORM-INT J ENDOCRINO, V18, P141, DOI 10.1007/s42000-019-00093-w
   Verdura S, 2019, ONCOIMMUNOLOGY, V8, DOI 10.1080/2162402X.2019.1633235
   Viollet B, 2012, CLIN SCI, V122, P253, DOI 10.1042/CS20110386
   Wang A, 2015, EJSO-EUR J SURG ONC, V41, P450, DOI 10.1016/j.ejso.2015.01.020
   Wang Y, 2018, ADV FUNCT MATER, V28, DOI 10.1002/adfm.201802847
   Wu AA, 2015, ONCOIMMUNOLOGY, V4, DOI 10.1080/2162402X.2015.1016700
   Wu CP, 2006, ACTA HISTOCHEM, V108, P19, DOI 10.1016/j.acthis.2006.01.003
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Xiong Y, 2019, NANOMED-NANOTECHNOL, V21, DOI 10.1016/j.nano.2019.102034
   Zamarron BF, 2011, INT J BIOL SCI, V7, P651, DOI 10.7150/ijbs.7.651
   Zelenay S, 2015, CELL, V162, P1257, DOI 10.1016/j.cell.2015.08.015
   Zhang JJ, 2019, AM J TRANSL RES, V11, P6965
   Zhao Y, 2016, NAT COMMUN, V7, DOI 10.1038/ncomms11822
   Zheng JL, 2018, J AGR FOOD CHEM, V66, P5821, DOI [10.1021/acsjafc.8b00829, 10.1021/acs.jafc.8b00829]
   Zhong L, 2014, WORLD J GASTROENTERO, V20, P7878, DOI 10.3748/wjg.v20.i24.7878
   Zhou F, 2015, LUNG CANCER, V89, P203, DOI 10.1016/j.lungcan.2015.06.005
   Zhou JY, 2018, GUT, V67, P931, DOI 10.1136/gutjnl-2017-314032
NR 70
TC 5
Z9 5
U1 1
U2 41
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2366-3987
J9 ADV THER-GERMANY
JI Adv. Therap.
PD DEC
PY 2020
VL 3
IS 12
AR 2000168
DI 10.1002/adtp.202000168
EA OCT 2020
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA PI7VT
UT WOS:000576367400001
DA 2023-06-08
ER

PT J
AU Song, L
   Cui, JQ
   Hu, SY
   Wang, R
   Li, HB
   Sun, B
AF Song, Lin
   Cui, Jiaqi
   Hu, Shuyuan
   Wang, Rui
   Li, Hongbao
   Sun, Bo
TI Maternal Treatment with Metformin Persistently Ameliorates High-Fat
   Diet-Induced Metabolic Symptoms and Modulates Gut Microbiota in Rat
   Offspring
SO NUTRIENTS
LA English
DT Article
DE maternal diet; metformin; gut microbiota; bile acids; hypothalamus
ID INTESTINAL MICROBIOTA; BILE-ACIDS; FOLLOW-UP; INCREASES; TRANSMISSION;
   SENSITIVITY; PHYSIOLOGY; AGONIST; HEALTH; MODEL
AB A maternal high-fat (HF) diet has long-term deleterious effect on offspring. This study aims to evaluate whether maternal metformin (MT) treatment ameliorates the adverse effects of maternal HF diet on offspring and the role of gut microbiota in it. Pregnant Sprague-Dawley rats were randomly assigned to a HF diet (60% fat) or a standard chow diet (11.8% fat) group, and part of the HF diet group rats were co-treated with MT via drinking water (300 mg/kg/day), resulting in three groups according to maternal diet and MT treatment during gestation and lactation. All offspring were weaned on a chow diet. A maternal HF diet showed a significant deleterious effect on offspring's metabolic phenotype and induced colonic inflammation and gut-barrier disruption through the reshaped gut microbiota. The daily oral administration of MT to HF-fed dams during gestation and lactation reversed the dysbiosis of gut microbiota in both dams and adult offspring. The hypothalamic TGR5 expression and plasma bile acids composition in adult male offspring was restored by maternal MT treatment, which could regulate hypothalamic appetite-related peptides expression and alleviate inflammation, thereby improving male offspring's metabolic phenotype. The present study indicates that targeting the gut-brain axis through the mother may be an effective strategy to control the metabolic phenotype of offspring.
C1 [Song, Lin; Hu, Shuyuan; Wang, Rui; Li, Hongbao; Sun, Bo] Xi An Jiao Tong Univ, Sch Basic Med Sci, Dept Physiol & Pathophysiol, Hlth Sci Ctr, Xian 710061, Peoples R China.
   [Song, Lin; Li, Hongbao; Sun, Bo] Xi An Jiao Tong Univ, Key Lab Environm & Genes Related Dis, Minist Educ China, Xian 710061, Peoples R China.
   [Song, Lin; Sun, Bo] Xi An Jiao Tong Univ, Inst Neurosci, Translat Med Inst, Hlth Sci Ctr, Xian 710061, Peoples R China.
   [Cui, Jiaqi] Xi An Jiao Tong Univ, Dept Hlth Management Ctr, Affiliated Hosp 1, Xian 710061, Peoples R China.
C3 Xi'an Jiaotong University; Ministry of Education, China; Xi'an Jiaotong
   University; Xi'an Jiaotong University; Xi'an Jiaotong University
RP Li, HB; Sun, B (通讯作者)，Xi An Jiao Tong Univ, Sch Basic Med Sci, Dept Physiol & Pathophysiol, Hlth Sci Ctr, Xian 710061, Peoples R China.; Li, HB; Sun, B (通讯作者)，Xi An Jiao Tong Univ, Key Lab Environm & Genes Related Dis, Minist Educ China, Xian 710061, Peoples R China.; Sun, B (通讯作者)，Xi An Jiao Tong Univ, Inst Neurosci, Translat Med Inst, Hlth Sci Ctr, Xian 710061, Peoples R China.
EM hongbaoli1985@163.com; sunbo1217@mail.xjtu.edu.cn
RI cui, jiaqi/HLX-3700-2023
OI Song, Lin/0000-0001-9500-8387; Li, Hong-Bao/0000-0002-1600-9590
FU National Natural Science Foundation of China [81801459, 82071732,
   82170443]; Key Research and Development Program of Shaanxi Province
   [2021SF-153]
FX This work was supported by the National Natural Science Foundation of
   China (No. 81801459; 82071732; 82170443), and the Key Research and
   Development Program of Shaanxi Province (No. 2021SF-153).
CR Ahmadi S, 2020, JCI INSIGHT, V5, DOI 10.1172/jci.insight.132055
   Bindels LB, 2015, NAT REV GASTRO HEPAT, V12, P303, DOI 10.1038/nrgastro.2015.47
   Bouret SG, 2010, FORUM NUTR, V63, P84, DOI 10.1159/000264396
   Bouret SG, 2004, J NEUROSCI, V24, P2797, DOI 10.1523/JNEUROSCI.5369-03.2004
   Castellanos-Jankiewicz A, 2021, CELL METAB, V33, P1483, DOI 10.1016/j.cmet.2021.04.009
   Catalano PM, 2021, OBSTET GYNECOL, V137, pE128, DOI 10.1097/AOG.0000000000004395
   Chen XS, 2011, EXP DIABETES RES, DOI 10.1155/2011/853501
   Cox LM, 2014, CELL, V158, P705, DOI 10.1016/j.cell.2014.05.052
   Czarnecka AM, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21207750
   Daniel H, 2014, ISME J, V8, P295, DOI 10.1038/ismej.2013.155
   David LA, 2014, NATURE, V505, P559, DOI 10.1038/nature12820
   Dearden L, 2020, MOL METAB, V42, DOI 10.1016/j.molmet.2020.101079
   Deckmyn B, 2022, FRONT MOL NEUROSCI, V14, DOI 10.3389/fnmol.2021.808603
   Desai N, 2013, AM J OBSTET GYNECOL, V209, DOI 10.1016/j.ajog.2013.05.001
   Ferretti P, 2018, CELL HOST MICROBE, V24, P133, DOI 10.1016/j.chom.2018.06.005
   Foley MH, 2021, P NATL ACAD SCI USA, V118, DOI 10.1073/pnas.2017709118
   Forcato S, 2017, REPROD TOXICOL, V74, P48, DOI 10.1016/j.reprotox.2017.08.023
   Frias AE, 2011, ENDOCRINOLOGY, V152, P2456, DOI 10.1210/en.2010-1332
   Fu J, 2022, DIABETES RES CLIN PR, V186, DOI 10.1016/j.diabres.2022.109811
   Gluckman PD, 2009, NAT REV ENDOCRINOL, V5, P401, DOI 10.1038/nrendo.2009.102
   Hafner H, 2019, NUTRIENTS, V11, DOI 10.3390/nu11061393
   Hanem LGE, 2019, LANCET CHILD ADOLESC, V3, P166, DOI 10.1016/S2352-4642(18)30385-7
   Hanem LGE, 2018, J CLIN ENDOCR METAB, V103, P1612, DOI 10.1210/jc.2017-02419
   Hsu CN, 2019, NUTRIENTS, V11, DOI 10.3390/nu11091982
   Hu X, 2021, BRAIN BEHAV IMMUN, V91, P587, DOI 10.1016/j.bbi.2020.09.016
   Huang SW, 2021, LIPIDS HEALTH DIS, V20, DOI 10.1186/s12944-021-01521-w
   Hyer S, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19071954
   Ijas H, 2011, BJOG-INT J OBSTET GY, V118, P880, DOI 10.1111/j.1471-0528.2010.02763.x
   Jin P, 2021, EXP NEUROL, V335, DOI 10.1016/j.expneurol.2020.113504
   Joyce SA, 2014, P NATL ACAD SCI USA, V111, P7421, DOI 10.1073/pnas.1323599111
   Kitahara M, 2000, INT J SYST EVOL MICR, V50, P971, DOI 10.1099/00207713-50-3-971
   Lee Y, 2021, DIABETES RES CLIN PR, V178, DOI 10.1016/j.diabres.2021.108985
   Lindsay RS, 2017, DIABETOLOGIA, V60, P1612, DOI 10.1007/s00125-017-4351-y
   Ma W, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.01336
   Mann PE, 2018, GUT MICROBES, V9, P143, DOI 10.1080/19490976.2017.1395122
   Moeller AH, 2018, SCIENCE, V362, P453, DOI 10.1126/science.aat7164
   Novi DRBS, 2020, ARCH PHYSIOL BIOCHEM, V126, P276, DOI 10.1080/13813455.2018.1517804
   Ong TP, 2015, CURR OPIN CLIN NUTR, V18, P354, DOI 10.1097/MCO.0000000000000177
   Osman MW, 2018, DIABETES RES CLIN PR, V139, P170, DOI 10.1016/j.diabres.2018.03.003
   Perino A, 2021, NAT METAB, V3, P595, DOI 10.1038/s42255-021-00398-4
   Perino A, 2021, PHYSIOL REV, V101, P683, DOI 10.1152/physrev.00049.2019
   Poston L, 2016, LANCET DIABETES ENDO, V4, P1025, DOI 10.1016/S2213-8587(16)30217-0
   Ramirez-Perez O, 2017, ANN HEPATOL, V16, pS21, DOI 10.5604/01.3001.0010.5672
   Rooks MG, 2016, NAT REV IMMUNOL, V16, P341, DOI 10.1038/nri.2016.42
   Rowan JA, 2018, BMJ OPEN DIAB RES CA, V6, DOI 10.1136/bmjdrc-2017-000456
   Rowan JA, 2011, DIABETES CARE, V34, P2279, DOI 10.2337/dc11-0660
   Salomaki H, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0115778
   Salomaki H, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0056594
   Salomaki-Myftari H, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0163805
   Schoonejans JM, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22158104
   Shah S, 2021, NUTRIENTS, V13, DOI 10.3390/nu13030892
   Shaw JL, 2003, J CHEM NEUROANAT, V26, P179, DOI 10.1016/j.jchemneu.2003.07.003
   Shi ZJ, 2021, J AGR FOOD CHEM, V69, P3982, DOI 10.1021/acs.jafc.0c07467
   Sonnenburg JL, 2016, NATURE, V535, P56, DOI 10.1038/nature18846
   Sun B, 2012, DIABETES, V61, P2833, DOI 10.2337/db11-0957
   Tain YL, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19041066
   Tarry-Adkins JL, 2022, FRONT CELL DEV BIOL, V10, DOI 10.3389/fcell.2022.935403
   Torres-Fuentes C, 2017, LANCET GASTROENTEROL, V2, P747, DOI 10.1016/S2468-1253(17)30147-4
   Vrieze A, 2012, GASTROENTEROLOGY, V143, P913, DOI 10.1053/j.gastro.2012.06.031
   Vuong HE, 2020, NATURE, V586, P281, DOI 10.1038/s41586-020-2745-3
   Wahlstrom A, 2016, CELL METAB, V24, P41, DOI 10.1016/j.cmet.2016.05.005
   Wang BT, 2020, NUTRIENTS, V12, DOI 10.3390/nu12103197
   Wang Y, 2014, BRAIN BEHAV IMMUN, V38, P1, DOI 10.1016/j.bbi.2013.12.015
   Watanabe K, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0202083
   Wei W, 2021, CLIN NUTR, V40, P4234, DOI 10.1016/j.clnu.2021.01.031
   Xie RX, 2018, FRONT IMMUNOL, V9, DOI 10.3389/fimmu.2018.02608
   Xu JL, 2020, MOL NUTR FOOD RES, V64, DOI 10.1002/mnfr.202000353
   Yang XB, 2020, FOOD FUNCT, V11, P2953, DOI [10.1039/d0fo00178c, 10.1039/D0FO00178C]
   Yanguas-Casas N, 2017, J CELL PHYSIOL, V232, P2231, DOI 10.1002/jcp.25742
   Yoshimoto S, 2013, NATURE, V499, P97, DOI 10.1038/nature12347
   Zhao YL, 2020, AGING-US, V12, P14019, DOI 10.18632/aging.103505
   Zheng XJ, 2017, BMC BIOL, V15, DOI 10.1186/s12915-017-0462-7
   Zhou LY, 2020, FRONT CELL INFECT MI, V10, DOI 10.3389/fcimb.2020.00292
NR 73
TC 1
Z9 1
U1 2
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD SEP
PY 2022
VL 14
IS 17
AR 3612
DI 10.3390/nu14173612
PG 20
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 4K1YF
UT WOS:000851753700001
PM 36079869
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Sun, LL
   Xie, C
   Wang, G
   Wu, Y
   Wu, Q
   Wang, XM
   Liu, J
   Deng, YY
   Xia, JL
   Chen, B
   Zhang, SY
   Yun, CY
   Lian, G
   Zhang, XJ
   Zhang, H
   Bisson, WH
   Shi, JM
   Gao, XX
   Ge, PP
   Liu, CH
   Krausz, KW
   Nichols, RG
   Cai, JW
   Rimal, B
   Patterson, AD
   Wang, X
   Gonzalez, FJ
   Jiang, CT
AF Sun, Lulu
   Xie, Cen
   Wang, Guang
   Wu, Yue
   Wu, Qing
   Wang, Xuemei
   Liu, Jia
   Deng, Yangyang
   Xia, Jialin
   Chen, Bo
   Zhang, Songyang
   Yun, Chuyu
   Lian, Guan
   Zhang, Xiujuan
   Zhang, Heng
   Bisson, William H.
   Shi, Jingmin
   Gao, Xiaoxia
   Ge, Pupu
   Liu, Cuihua
   Krausz, Kristopher W.
   Nichols, Robert G.
   Cai, Jingwei
   Rimal, Bipin
   Patterson, Andrew D.
   Wang, Xian
   Gonzalez, Frank J.
   Jiang, Changtao
TI Gut microbiota and intestinal FXR mediate the clinical benefits of
   metformin
SO NATURE MEDICINE
LA English
DT Article
ID FARNESOID-X-RECEPTOR; BILE-ACID SYNTHESIS; BETA-MURICHOLIC ACID;
   METABOLISM; LIVER; AXIS; GLUCONEOGENESIS; HOMEOSTASIS; PROBIOTICS;
   MECHANISM
AB The anti-hyperglycemic effect of metformin is believed to be caused by its direct action on signaling processes in hepatocytes, leading to lower hepatic gluconeogenesis. Recently, metformin was reported to alter the gut microbiota community in humans, suggesting that the hyperglycemia-lowering action of the drug could be the result of modulating the population of gut microbiota. However, the critical microbial signaling metabolites and the host targets associated with the metabolic benefits of metformin remained elusive. Here, we performed metagenomic and metabolomic analysis of samples from individuals with newly diagnosed type 2 diabetes (T2D) naively treated with metformin for 3 d, which revealed that Bacteroides fragilis was decreased and the bile acid glycoursodeoxycholic acid (GUDCA) was increased in the gut. These changes were accompanied by inhibition of intestinal farnesoid X receptor (FXR) signaling. We further found that high-fat-diet (HFD)-fed mice colonized with B. fragilis were predisposed to more severe glucose intolerance, and the metabolic benefits of metformin treatment on glucose intolerance were abrogated. GUDCA was further identified as an intestinal FXR antagonist that improved various metabolic endpoints in mice with established obesity. Thus, we conclude that metformin acts in part through a B. fragilis-GUDCA-intestinal FXR axis to improve metabolic dysfunction, including hyperglycemia.
C1 [Sun, Lulu; Wu, Qing; Wang, Xuemei; Xia, Jialin; Chen, Bo; Zhang, Songyang; Yun, Chuyu; Lian, Guan; Zhang, Xiujuan; Jiang, Changtao] Peking Univ, Sch Basic Med Sci, Dept Physiol & Pathophysiol, Beijing, Peoples R China.
   [Sun, Lulu; Wu, Qing; Wang, Xuemei; Xia, Jialin; Chen, Bo; Zhang, Songyang; Yun, Chuyu; Lian, Guan; Zhang, Xiujuan; Jiang, Changtao] Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing, Peoples R China.
   [Xie, Cen; Shi, Jingmin; Gao, Xiaoxia; Krausz, Kristopher W.; Gonzalez, Frank J.] NCI, Lab Metab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.
   [Wang, Guang; Liu, Jia; Zhang, Heng] Capital Med Univ, Beijing Chao Yang Hosp, Dept Endocrinol, Beijing, Peoples R China.
   [Wu, Yue; Deng, Yangyang] Xi An Jiao Tong Univ, Dept Cardiol, Key Lab Environm & Genes Related Dis, Affiliated Hosp 1, Xian, Shaanxi, Peoples R China.
   [Bisson, William H.] Oregon State Univ, Dept Environm & Mol Toxicol, Corvallis, OR 97331 USA.
   [Ge, Pupu; Liu, Cuihua] Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing, Peoples R China.
   [Nichols, Robert G.; Cai, Jingwei; Rimal, Bipin; Patterson, Andrew D.] Penn State Univ, Dept Mol Toxicol, University Pk, PA 16802 USA.
C3 Peking University; National Institutes of Health (NIH) - USA; NIH
   National Cancer Institute (NCI); Capital Medical University; Xi'an
   Jiaotong University; Oregon State University; Chinese Academy of
   Sciences; Institute of Microbiology, CAS; Pennsylvania Commonwealth
   System of Higher Education (PCSHE); Pennsylvania State University;
   Pennsylvania State University - University Park
RP Jiang, CT (通讯作者)，Peking Univ, Sch Basic Med Sci, Dept Physiol & Pathophysiol, Beijing, Peoples R China.; Jiang, CT (通讯作者)，Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing, Peoples R China.
EM jiangchangtao@bjmu.edu.cn
RI Xie, Cen/HKM-6955-2023; Shi, Jing/HHS-6413-2022; Wang,
   Xuemei/GXF-3702-2022; Patterson, Andrew/ABF-1575-2020; Rimal,
   Bipin/HHN-1529-2022
OI Xie, Cen/0000-0002-4574-8456; Patterson, Andrew/0000-0003-2073-0070;
   Song-Yang, Zhang/0000-0002-4356-897X; Cai, Jingwei/0000-0002-3626-3350;
   Sun, Lulu/0000-0001-8876-5099; Bo, Chen/0000-0003-4346-0755; Gonzalez,
   Frank/0000-0002-7990-2140; Deng, Yang-Yang/0000-0002-6470-2891; Nichols,
   Robert/0000-0002-5415-7877; Jiang, Changtao/0000-0002-5206-2372
FU National Key Research and Development Program of China [2016YFC0903100,
   2016YFC0903102]; National Natural Science Foundation of China [91439206,
   91739303, 81522007, 81470554, 31401011]; National Program for Support of
   Top-notch Young Professionals [82008Y0005]; Fundamental Research Funds
   for the Central Universities: Clinical Medicine Plus X-Young Scholars
   Project of Peking University [PKU2018LCXQ013]; National Cancer Institute
   Intramural Research Program
FX This work was supported by the National Key Research and Development
   Program of China (2016YFC0903100 and 2016YFC0903102) to C.J., the
   National Natural Science Foundation of China (91439206 and 91739303 to
   X.W., and 81522007, 81470554 and 31401011 to C.J.), the National Program
   for Support of Top-notch Young Professionals (82008Y0005) to C.J., the
   Fundamental Research Funds for the Central Universities: Clinical
   Medicine Plus X-Young Scholars Project of Peking University
   (PKU2018LCXQ013) to C.J., and the National Cancer Institute Intramural
   Research Program to F.J.G.
CR Akwabi-Ameyaw A, 2008, BIOORG MED CHEM LETT, V18, P4339, DOI 10.1016/j.bmcl.2008.06.073
   Bailey CJ, 2008, DIABETOLOGIA, V51, P1552, DOI 10.1007/s00125-008-1053-5
   Bauer PV, 2018, CELL METAB, V27, P572, DOI 10.1016/j.cmet.2018.01.013
   Bauer PV, 2018, CELL METAB, V27, P101, DOI 10.1016/j.cmet.2017.09.019
   Cabreiro F, 2013, CELL, V153, P228, DOI 10.1016/j.cell.2013.02.035
   Degirolamo C, 2014, CELL REP, V7, P12, DOI 10.1016/j.celrep.2014.02.032
   Deschasaux M, 2018, NAT MED, V24, P1526, DOI 10.1038/s41591-018-0160-1
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Friedman SL, 2018, NAT MED, V24, P908, DOI 10.1038/s41591-018-0104-9
   Fujita K, 2017, LIPIDS, V52, P335, DOI 10.1007/s11745-017-4242-5
   Geach T, 2017, NAT REV ENDOCRINOL, V13, P66, DOI 10.1038/nrendo.2016.201
   Gonzalez FJ, 2016, GASTROENTEROLOGY, V151, P845, DOI 10.1053/j.gastro.2016.08.057
   Gu YY, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-01682-2
   Jiang CT, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms10166
   Jiang CT, 2015, J CLIN INVEST, V125, P386, DOI 10.1172/JCI76738
   Kim I, 2007, J LIPID RES, V48, P2664, DOI 10.1194/jlr.M700330-JLR200
   Kong B, 2012, HEPATOLOGY, V56, P1034, DOI 10.1002/hep.25740
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Li F, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms3384
   Lien F, 2014, J CLIN INVEST, V124, P1037, DOI 10.1172/JCI68815
   Madiraju AK, 2018, NAT MED, V24, P1384, DOI 10.1038/s41591-018-0125-4
   Madiraju AK, 2014, NATURE, V510, P542, DOI 10.1038/nature13270
   Matsubara T, 2013, MOL CELL ENDOCRINOL, V368, P17, DOI 10.1016/j.mce.2012.05.004
   Mueller M, 2015, J HEPATOL, V62, P1398, DOI 10.1016/j.jhep.2014.12.034
   Nakada D, 2010, NATURE, V468, P653, DOI 10.1038/nature09571
   Napolitano A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100778
   Olgun A, 2017, MED HYPOTHESES, V106, P33, DOI [10.1016/j.mehy.2017.07.009, 10.1016]
   Parseus A, 2017, GUT, V66, P429, DOI 10.1136/gutjnl-2015-310283
   Pathak P, 2018, HEPATOLOGY, V68, P1574, DOI 10.1002/hep.29857
   Pathak P, 2017, J BIOL CHEM, V292, P11055, DOI 10.1074/jbc.M117.784322
   Rena G, 2017, DIABETOLOGIA, V60, P1577, DOI 10.1007/s00125-017-4342-z
   Sayin SI, 2013, CELL METAB, V17, P225, DOI 10.1016/j.cmet.2013.01.003
   Schaeffer L, 2017, Bioinformatics, V33, P2082, DOI 10.1093/bioinformatics/btx106
   Schroeder B, 2016, NAT MED, V22, P1079, DOI 10.1038/nm.4185
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Singhal A, 2014, SCI TRANSL MED, V6, DOI 10.1126/scitranslmed.3009885
   STELLWAG EJ, 1976, BIOCHIM BIOPHYS ACTA, V452, P165, DOI 10.1016/0005-2744(76)90068-1
   Takahashi S, 2016, J LIPID RES, V57, P2130, DOI 10.1194/jlr.M071183
   Trabelsi MS, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms8629
   Tsuchida T, 2012, METABOLISM, V61, P944, DOI 10.1016/j.metabol.2011.10.023
   Vallim TQD, 2013, CELL METAB, V17, P657, DOI 10.1016/j.cmet.2013.03.013
   Vetizou M, 2015, SCIENCE, V350, P1079, DOI 10.1126/science.aad1329
   Wahlstrom A, 2016, CELL METAB, V24, P41, DOI 10.1016/j.cmet.2016.05.005
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Xie C, 2017, DIABETES, V66, P613, DOI 10.2337/db16-0663
   Zhang LC, 2016, BMC BIOTECHNOL, V16, DOI 10.1186/s12896-016-0294-5
   Zhang XQ, 2015, SCI REP-UK, V5, DOI 10.1038/srep10737
   Zhou GC, 2001, J CLIN INVEST, V108, P1167, DOI 10.1172/JCI200113505
   Zietak M, 2016, CELL METAB, V23, P1216, DOI 10.1016/j.cmet.2016.05.001
NR 49
TC 437
Z9 473
U1 43
U2 398
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 1078-8956
EI 1546-170X
J9 NAT MED
JI Nat. Med.
PD DEC
PY 2018
VL 24
IS 12
BP 1919
EP +
DI 10.1038/s41591-018-0222-4
PG 13
WC Biochemistry & Molecular Biology; Cell Biology; Medicine, Research &
   Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology; Research & Experimental
   Medicine
GA HD3DA
UT WOS:000452392200021
PM 30397356
OA Green Accepted
HC Y
HP N
DA 2023-06-08
ER

PT J
AU Ji, SQ
   Wang, LW
   Li, L
AF Ji, Shuqin
   Wang, Lingwei
   Li, Lei
TI Effect of Metformin on Short-Term High-Fat Diet-Induced Weight Gain and
   Anxiety-Like Behavior and the Gut Microbiota
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE high-fat diet; metformin; anxiety; gut microbiota; obesity
ID ACTIVATED PROTEIN-KINASE; INDUCED OBESITY; DEPRESSION; DISORDERS; MICE;
   PATHWAY; FEAR; ASSOCIATION; ONDANSETRON; POPULATION
AB The pathogenic factors of the complex epidemic disorder-obesity, have expanded from genetic background, endocrine factors, abnormal feeding behaviors, and direct neural control of adipose tissue physiology. As a chronic metabolic disease, it is important to find new potential therapeutic targets and locate a sensitive time window for intervention. In this study, we focus on the early stage of a high-fat diet mouse model: a short-term 3-week treatment. Our results showed that this short-term 3-week HFD can already induce significant body weight gain, increased adipocyte size and surprisingly, anxiety-like behavior of the animals. Then we tried the early intervention with metformin, already reported for its effects in long-term HFD induced obesity. For a short-term 3-week co-treatment, metformin alleviated the HFD-induced increase in body weight, the increase in adipocyte size and furthermore, the anxiety-like behavior. Differences were noted among the normal diet (ND), HFD, and HFD with metformin co-treatment groups in gut microbiota, including its composition and diversity. The possible involvement of gut microbiota cannot be ruled out. Intense phospho-AMPK staining was found in the metformin treatment group in the habenular nuclei, hippocampus and basal ganglia of the brain compared with the HFD group, implying that the anxiolytic effect of metformin could be due to the direct activation of the AMPK pathway in the anxiety-related brain nuclei.
C1 [Ji, Shuqin; Li, Lei] Chinese Acad Sci, Brain Cognit & Brain Dis Inst, Shenzhen Inst Adv Technol, Guangdong Prov Key Lab Brain Connectome & Behav, Shenzhen, Peoples R China.
   [Wang, Lingwei] Jinan Univ, Shenzhen Key Lab Resp Dis,Shenzhen Key Lab Pathog, Dept Resp & Crit Care Med,Southern Sci & Technol, Shenzhen Inst Resp Dis,Shenzhen Peoples Hosp,Affi, Shenzhen, Peoples R China.
C3 Chinese Academy of Sciences; Shenzhen Institute of Advanced Technology,
   CAS; Jinan University
RP Li, L (通讯作者)，Chinese Acad Sci, Brain Cognit & Brain Dis Inst, Shenzhen Inst Adv Technol, Guangdong Prov Key Lab Brain Connectome & Behav, Shenzhen, Peoples R China.
EM saralilei@siat.ac.cn
OI Li, Lei/0000-0002-4485-1937
FU National Natural Science Foundation of China [NSFC31971072,
   NSFC81671444, NSFC31471109]; Shenzhen Science Technology, and Innovative
   Commission Grant [JCYJ20180508152336419, KQJSCX20160301144002];
   Guangdong Provincial Key Laboratory of Brain Connectome and Behavior
   [2017B030301017]; Shenzhen Discipline Construction Project for
   Neurobiology DRCSM [[2016]1379]
FX This work was supported by the National Natural Science Foundation of
   China NSFC31971072, NSFC81671444, NSFC31471109. Shenzhen Science
   Technology, and Innovative Commission Grant JCYJ20180508152336419,
   KQJSCX20160301144002, and Guangdong Provincial Key Laboratory of Brain
   Connectome and Behavior 2017B030301017 and Shenzhen Discipline
   Construction Project for Neurobiology DRCSM [2016]1379.
CR Adeyemo MA, 2015, DIABETES OBES METAB, V17, P363, DOI 10.1111/dom.12426
   Almeida-Suhett CP, 2019, NUTR NEUROSCI, V22, P19, DOI 10.1080/1028415X.2017.1349359
   Almeida-Suhett CP, 2017, PHYSIOL BEHAV, V169, P130, DOI 10.1016/j.physbeh.2016.11.016
   Andre C, 2014, BRAIN BEHAV IMMUN, V41, P10, DOI 10.1016/j.bbi.2014.03.012
   Bailey CJ, 1996, NEW ENGL J MED, V334, P574, DOI 10.1056/NEJM199602293340906
   Bailey CJ, 2017, DIABETOLOGIA, V60, P1566, DOI 10.1007/s00125-017-4318-z
   Beiroa D, 2014, DIABETES, V63, P3346, DOI 10.2337/db14-0302
   Moreira APB, 2012, BRIT J NUTR, V108, P801, DOI 10.1017/S0007114512001213
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Cordner ZA, 2015, PHYSIOL BEHAV, V152, P363, DOI 10.1016/j.physbeh.2015.06.008
   De Angelis M, 2015, GUT MICROBES, V6, P207, DOI 10.1080/19490976.2015.1035855
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Depommier C, 2019, NAT MED, V25, P1096, DOI 10.1038/s41591-019-0495-2
   Dong C, 2004, INT J OBESITY, V28, P790, DOI 10.1038/sj.ijo.0802626
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Fond G, 2015, PATHOL BIOL, V63, P35, DOI 10.1016/j.patbio.2014.10.003
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Gariepy G, 2010, INT J OBESITY, V34, P407, DOI 10.1038/ijo.2009.252
   Gariepy G, 2010, OBESITY, V18, P1033, DOI 10.1038/oby.2009.333
   GIUGLIANO D, 1993, DIABETES CARE, V16, P1387, DOI 10.2337/diacare.16.10.1387
   Gupta D, 2014, EUR J PHARMACOL, V744, P59, DOI 10.1016/j.ejphar.2014.09.041
   Hryhorczuk C, 2013, FRONT NEUROSCI-SWITZ, V7, DOI 10.3389/fnins.2013.00177
   Jiang HY, 2018, J PSYCHIATR RES, V104, P130, DOI 10.1016/j.jpsychires.2018.07.007
   Kang SS, 2014, MOL NEURODEGENER, V9, DOI 10.1186/1750-1326-9-36
   Kheirbek MA, 2013, NEURON, V77, P955, DOI 10.1016/j.neuron.2012.12.038
   Klein J, 2004, J ENDOCRINOL, V183, P299, DOI 10.1677/joe.1.05646
   Kurhe Y, 2015, PHARMACOL BIOCHEM BE, V136, P107, DOI 10.1016/j.pbb.2015.07.004
   Kurhe Y, 2014, NEUROCHEM RES, V39, P1395, DOI 10.1007/s11064-014-1322-2
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Lennox R, 2014, NEUROPHARMACOLOGY, V86, P22, DOI 10.1016/j.neuropharm.2014.06.026
   Ley RE, 2005, P NATL ACAD SCI USA, V102, P11070, DOI 10.1073/pnas.0504978102
   Luna RA, 2015, CURR OPIN BIOTECH, V32, P35, DOI 10.1016/j.copbio.2014.10.007
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Malkki H, 2014, NAT REV NEUROL, V10, P243, DOI [10.1038/nrneurol.2014.63, 10.1038/nrneurol.2013.250, 10.1038/nrneurol.2014.21, 10.1038/nrneurol.2014.168, 10.1038/nrneurol.2014.209, 10.1038/nrneurol.2013.267, 10.1038/nrneurol.2014.61, 10.1038/nrneurol.2014.142]
   Mangiola F, 2016, WORLD J GASTROENTERO, V22, P361, DOI 10.3748/wjg.v22.i1.361
   Marchand WR, 2010, BRAIN STRUCT FUNCT, V215, P73, DOI 10.1007/s00429-010-0280-y
   McHugh SB, 2004, BEHAV NEUROSCI, V118, P63, DOI 10.1037/0735-7044.118.1.63
   Naseribafrouei A, 2014, NEUROGASTROENT MOTIL, V26, P1155, DOI 10.1111/nmo.12378
   Okamoto H, 2013, NEURON, V78, P411, DOI 10.1016/j.neuron.2013.04.031
   Onyike CU, 2003, AM J EPIDEMIOL, V158, P1139, DOI 10.1093/aje/kwg275
   Rangarajan S, 2018, NAT MED, V24, P1121, DOI 10.1038/s41591-018-0087-6
   Rena G, 2017, DIABETOLOGIA, V60, P1577, DOI 10.1007/s00125-017-4342-z
   Sharma S, 2013, INT J OBESITY, V37, P1183, DOI 10.1038/ijo.2012.197
   Sharma S, 2013, INT J OBESITY, V37, P382, DOI 10.1038/ijo.2012.48
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Stunkard AJ, 2003, BIOL PSYCHIAT, V54, P330, DOI 10.1016/S0006-3223(03)00608-5
   Tovote P, 2015, NAT REV NEUROSCI, V16, P317, DOI 10.1038/nrn3945
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Wang J, 2012, CELL STEM CELL, V11, P23, DOI 10.1016/j.stem.2012.03.016
   WU JC, 1991, BIOL PSYCHIAT, V29, P1181, DOI 10.1016/0006-3223(91)90326-H
   Zemdegs J, 2016, BRIT J PHARMACOL, V173, P2095, DOI 10.1111/bph.13343
   Zeng WW, 2015, CELL, V163, P84, DOI 10.1016/j.cell.2015.08.055
   Zheng P, 2016, MOL PSYCHIATR, V21, P786, DOI 10.1038/mp.2016.44
   Zhou GC, 2001, J CLIN INVEST, V108, P1167, DOI 10.1172/JCI200113505
NR 54
TC 21
Z9 21
U1 4
U2 16
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD OCT 18
PY 2019
VL 10
AR 704
DI 10.3389/fendo.2019.00704
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA JJ7TA
UT WOS:000494355300001
PM 31681174
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Kaneto, H
   Kimura, T
   Obata, A
   Shimoda, M
   Kaku, K
AF Kaneto, Hideaki
   Kimura, Tomohiko
   Obata, Atsushi
   Shimoda, Masashi
   Kaku, Kohei
TI Multifaceted Mechanisms of Action of Metformin Which Have Been Unraveled
   One after Another in the Long History
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE metformin; AMPK; glucagon signaling; autophagy; GDF15; gut microbiome;
   mTOR; COVID-19
ID PANCREATIC BETA-CELLS; TYPE-2 DIABETES-MELLITUS; ENDOTHELIAL-CELLS;
   DB/DB MICE; CARDIOVASCULAR OUTCOMES; DOWN-REGULATION; RECEPTOR
   EXPRESSION; PEPTIDE-1 RECEPTOR; INSULIN-RESISTANCE; MAFA EXPRESSION
AB While there are various kinds of drugs for type 2 diabetes mellitus at present, in this review article, we focus on metformin which is an insulin sensitizer and is often used as a first-choice drug worldwide. Metformin mainly activates adenosine monophosphate-activated protein kinase (AMPK) in the liver which leads to suppression of fatty acid synthesis and gluconeogenesis. Metformin activates AMPK in skeletal muscle as well, which increases translocation of glucose transporter 4 to the cell membrane and thereby increases glucose uptake. Further, metformin suppresses glucagon signaling in the liver by suppressing adenylate cyclase which leads to suppression of gluconeogenesis. In addition, metformin reduces autophagy failure observed in pancreatic beta-cells under diabetic conditions. Furthermore, it is known that metformin alters the gut microbiome and facilitates the transport of glucose from the circulation into excrement. It is also known that metformin reduces food intake and lowers body weight by increasing circulating levels of the peptide hormone growth/differentiation factor 15 (GDF15). Furthermore, much attention has been drawn to the fact that the frequency of various cancers is lower in subjects taking metformin. Metformin suppresses the mechanistic target of rapamycin (mTOR) by activating AMPK in pre-neoplastic cells, which leads to suppression of cell growth and an increase in apoptosis in pre-neoplastic cells. It has been shown recently that metformin consumption potentially influences the mortality in patients with type 2 diabetes mellitus and coronavirus infectious disease (COVID-19). Taken together, metformin is an old drug, but multifaceted mechanisms of action of metformin have been unraveled one after another in its long history.
C1 [Kaneto, Hideaki; Kimura, Tomohiko; Obata, Atsushi; Shimoda, Masashi; Kaku, Kohei] Kawasaki Med Sch, Dept Diabet Endocrinol & Metab, 577 Matsushima, Kurashiki, Okayama 7010192, Japan.
C3 Kawasaki Medical School
RP Kaneto, H (通讯作者)，Kawasaki Med Sch, Dept Diabet Endocrinol & Metab, 577 Matsushima, Kurashiki, Okayama 7010192, Japan.
EM kaneto@med.kawasaki-m.ac.jp; tomohiko@med.kawasaki-m.ac.jp;
   obata-tky@med.kawasaki-m.ac.jp; masashi-s@med.kawasaki-m.ac.jp;
   kka@med.kawasaki-m.ac.jp
OI Obata, Atsushi/0000-0003-4984-4098; Kimura, Tomohiko/0000-0003-3986-9494
CR Ahlgren U, 1998, GENE DEV, V12, P1763, DOI 10.1101/gad.12.12.1763
   Apolzan JW, 2019, ANN INTERN MED, V170, P682, DOI 10.7326/M18-1605
   Arakawa M, 2010, DIABETES, V59, P1030, DOI 10.2337/db09-1694
   Bailey CJ, 2005, DIABETES OBES METAB, V7, P675, DOI 10.1111/j.1463-1326.2005.00497.x
   Bartolome A, 2014, DIABETES, V63, P2996, DOI 10.2337/db13-0970
   Calle EE, 2004, NAT REV CANCER, V4, P579, DOI 10.1038/nrc1408
   Cariou B, 2020, DIABETOLOGIA, V63, P1500, DOI 10.1007/s00125-020-05180-x
   Cefalu WT, 2014, J CLIN INVEST, V124, P485, DOI 10.1172/JCI74297
   Chan AT, 2016, LANCET ONCOL, V17, P407, DOI 10.1016/S1470-2045(16)00006-1
   Chen YC, 2020, DIABETES CARE, V43, P1399, DOI 10.2337/dc20-0660
   Cheng X, 2020, CELL METAB, V32, P537, DOI 10.1016/j.cmet.2020.08.013
   Cimino I, 2017, NAT MED, V23, P1119, DOI 10.1038/nm.4414
   Coll AP, 2020, NATURE, V578, P444, DOI 10.1038/s41586-019-1911-y
   Demb J, 2019, CLIN TRANSL GASTROEN, V10, DOI 10.14309/ctg.0000000000000092
   Dowling RJO, 2007, CANCER RES, V67, P10804, DOI 10.1158/0008-5472.CAN-07-2310
   Ebato C, 2008, CELL METAB, V8, P325, DOI 10.1016/j.cmet.2008.08.009
   Emmerson PJ, 2017, NAT MED, V23, P1215, DOI 10.1038/nm.4393
   Ferrannini E, 2014, J CLIN INVEST, V124, P499, DOI 10.1172/JCI72227
   Fujitani Y, 2009, ISLETS, V1, P151, DOI 10.4161/isl.1.2.9057
   Gerstein HC, 2019, LANCET, V394, P121, DOI 10.1016/S0140-6736(19)31149-3
   Gerstein HC, 2017, DIABETES CARE, V40, P280, DOI 10.2337/dc16-1682
   Goto H, 2011, BIOCHEM BIOPH RES CO, V405, P79, DOI 10.1016/j.bbrc.2010.12.131
   Gregg EW, 2018, LANCET, V391, P2430, DOI [10.1016/S0140-6736(18)30314-3, 10.1016/s0140-6736(18)30314-3]
   Guan W, 2020, NEW ENGL J MED, V382, P1708, DOI [10.1056/NEJMoa2002032, 10.1056/NEJMc2005203]
   Halban PA, 2014, DIABETES CARE, V37, P1751, DOI 10.2337/dc14-0396
   Hamamoto S, 2013, DIABETES OBES METAB, V15, P153, DOI 10.1111/dom.12005
   Hashimoto S, 2015, DIABETES, V64, P876, DOI 10.2337/db14-0432
   Helmstadter J, 2020, ARTERIOSCL THROM VAS, V40, P145, DOI 10.1161/atv.0000615456.97862.30
   Hirukawa H, 2015, MOL CELL ENDOCRINOL, V413, P49, DOI 10.1016/j.mce.2015.06.010
   Holland AM, 2002, P NATL ACAD SCI USA, V99, P12236, DOI 10.1073/pnas.192255099
   Hsu JY, 2017, NATURE, V550, P255, DOI 10.1038/nature24042
   Huang I, 2020, DIABETES METAB SYND, V14, P395, DOI 10.1016/j.dsx.2020.04.018
   Husain M, 2019, NEW ENGL J MED, V381, P841, DOI 10.1056/NEJMoa1901118
   Husain M, 2020, DIABETES OBES METAB, V22, P442, DOI 10.1111/dom.13955
   Iqbal AM, 2021, CURR DRUG SAF, V16, P197, DOI 10.2174/1574886315999201208212356
   Ito J, 2021, DIABETES OBES METAB, V23, P692, DOI 10.1111/dom.14262
   Kaneto H, 2002, J BIOL CHEM, V277, P30010, DOI 10.1074/jbc.M202066200
   Kaneto H, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21249444
   Kaneto H, 2016, J DIABETES, V8, P183, DOI 10.1111/1753-0407.12331
   Kaneto H, 2015, INT J MOL SCI, V16, P6281, DOI 10.3390/ijms16036281
   Kaul S, 2017, DIABETES CARE, V40, P821, DOI 10.2337/dc17-0291
   Kawamori D, 2006, J BIOL CHEM, V281, P1091, DOI 10.1074/jbc.M508510200
   Kawashima S, 2011, BIOCHEM BIOPH RES CO, V404, P534, DOI 10.1016/j.bbrc.2010.12.021
   Kim YS, 2020, NUTR METAB CARDIOVAS, V30, P1714, DOI 10.1016/j.numecd.2020.05.010
   Kimura T, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-28849-1
   Kimura T, 2018, DIABETES OBES METAB, V20, P2442, DOI 10.1111/dom.13400
   Kimura T, 2017, DIABETES VASC DIS RE, V14, P540, DOI 10.1177/1479164117725898
   Kimura T, 2015, MOL CELL ENDOCRINOL, V400, P78, DOI 10.1016/j.mce.2014.11.018
   Kondo T, 2003, J CLIN INVEST, V111, P1835, DOI 10.1172/JCI200317455
   Konishi M, 2017, P NATL ACAD SCI USA, V114, pE8478, DOI 10.1073/pnas.1710625114
   Kourelis TV, 2012, MED ONCOL, V29, P1314, DOI 10.1007/s12032-011-9846-7
   Kristensen SL, 2019, LANCET DIABETES ENDO, V7, P776, DOI 10.1016/S2213-8587(19)30249-9
   Kubo F, 2016, BIOCHEM BIOPH RES CO, V471, P68, DOI 10.1016/j.bbrc.2016.01.177
   Kubota T, 2011, CELL METAB, V13, P294, DOI 10.1016/j.cmet.2011.01.018
   Lee JW, 2021, INT J COLORECTAL DIS, V36, P303, DOI 10.1007/s00384-020-03765-x
   Liu ZY, 2008, J BIOL CHEM, V283, P8723, DOI 10.1074/jbc.M706105200
   Lukito AA, 2020, DIABETES METAB SYND, V14, P2177, DOI 10.1016/j.dsx.2020.11.006
   Madiraju AK, 2014, NATURE, V510, P542, DOI 10.1038/nature13270
   Marso SP, 2016, NEW ENGL J MED, V375, P311, DOI 10.1056/NEJMoa1603827
   Masini M, 2009, DIABETOLOGIA, V52, P1083, DOI 10.1007/s00125-009-1347-2
   Masini M, 2009, ISLETS, V1, P157, DOI 10.4161/isl.1.2.9372
   Matsuoka T, 2015, J BIOL CHEM, V290, P7647, DOI 10.1074/jbc.M114.595579
   Matsuoka T, 2010, DIABETES, V59, P1709, DOI 10.2337/db08-0693
   Mayor S, 2005, LANCET ONCOL, V6, P71, DOI 10.1016/S1470-2045(05)01726-2
   Merovci A, 2014, J CLIN INVEST, V124, P509, DOI 10.1172/JCI70704
   Miller RA, 2013, NATURE, V494, P256, DOI 10.1038/nature11808
   Minamii T, 2018, J DIABETES INVEST, V9, P701, DOI 10.1111/jdi.12864
   Mita T, 2016, DIABETES CARE, V39, P455, DOI 10.2337/dc15-2145
   Mita T, 2016, DIABETES CARE, V39, P139, DOI 10.2337/dc15-0781
   Mitchell RK, 2015, HUM MOL GENET, V24, P1390, DOI 10.1093/hmg/ddu553
   Morita Y, 2020, DIABETES CARE, V43, P1796, DOI 10.2337/dc20-0093
   Mukai Y, 2006, J CLIN INVEST, V116, P334, DOI 10.1172/JCI26223
   Mullican SE, 2017, NAT MED, V23, P1150, DOI 10.1038/nm.4392
   Nishimura W, 2015, DIABETOLOGIA, V58, P566, DOI 10.1007/s00125-014-3464-9
   Noto H, 2013, J DIABETES INVEST, V4, P225, DOI 10.1111/jdi.12068
   Noto H, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0033411
   Obata A, 2019, DIABETOLOGIA, V62, P1225, DOI 10.1007/s00125-019-4878-1
   Obata A, 2016, ENDOCRINOLOGY, V157, P1029, DOI 10.1210/en.2015-1588
   Okauchi S, 2016, BIOCHEM BIOPH RES CO, V470, P772, DOI 10.1016/j.bbrc.2015.10.109
   Patel S, 2019, CELL METAB, V29, P707, DOI 10.1016/j.cmet.2018.12.016
   Penlioglou T, 2020, DIABETES THER, V11, P1195, DOI 10.1007/s13300-020-00830-0
   Poitout V, 2002, ENDOCRINOLOGY, V143, P339, DOI 10.1210/en.143.2.339
   Rahman A, 2014, LANCET ONCOL, V15, pE420, DOI 10.1016/S1470-2045(14)70368-7
   Rena G, 2017, DIABETOLOGIA, V60, P1577, DOI 10.1007/s00125-017-4342-z
   Rhodes CJ, 2005, SCIENCE, V307, P380, DOI 10.1126/science.1104345
   Sanada J, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-020-80894-x
   Shi YQ, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000021687
   Shi YK, 2014, LANCET, V383, P1947, DOI 10.1016/S0140-6736(14)60886-2
   Shimo N, 2015, BIOCHEM BIOPH RES CO, V467, P948, DOI 10.1016/j.bbrc.2015.10.038
   Shimoda M, 2011, DIABETOLOGIA, V54, P1098, DOI 10.1007/s00125-011-2069-9
   Shu LA, 2009, HUM MOL GENET, V18, P2388, DOI 10.1093/hmg/ddp178
   Smith SA, 2003, BIOCHIMIE, V85, P1219, DOI 10.1016/j.biochi.2003.10.010
   Takamoto I, 2014, DIABETOLOGIA, V57, P542, DOI 10.1007/s00125-013-3131-6
   Tsai VWW, 2018, CELL METAB, V28, P353, DOI 10.1016/j.cmet.2018.07.018
   Verma S, 2018, CIRCULATION, V138, P2884, DOI 10.1161/CIRCULATIONAHA.118.034516
   Walker JJ, 2013, LANCET DIABETES ENDO, V1, P132, DOI 10.1016/S2213-8587(13)70028-7
   Wang H, 2007, DIABETOLOGIA, V50, P348, DOI 10.1007/s00125-006-0490-2
   Watada H, 2015, MOL ENDOCRINOL, V29, P338, DOI 10.1210/me.2014-1367
   Weir GC, 2001, DIABETES, V50, pS154, DOI 10.2337/diabetes.50.2007.S154
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Xu G, 2007, DIABETES, V56, P1551, DOI 10.2337/db06-1033
   Yamamoto K, 2013, J BIOL CHEM, V288, P21648, DOI 10.1074/jbc.M113.481424
   Yamamoto Y, 2017, BIOCHEM BIOPH RES CO, V483, P418, DOI 10.1016/j.bbrc.2016.12.128
   Yang LD, 2017, NAT MED, V23, P1158, DOI 10.1038/nm.4394
   Zhou GC, 2001, J CLIN INVEST, V108, P1167, DOI 10.1172/JCI200113505
   Zhou Q, 2008, NATURE, V455, P627, DOI 10.1038/nature07314
   Zhu N, 2020, NEW ENGL J MED, V382, P727, DOI 10.1056/NEJMoa2001017
NR 107
TC 22
Z9 24
U1 6
U2 17
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAR
PY 2021
VL 22
IS 5
AR 2596
DI 10.3390/ijms22052596
PG 13
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA QV9GY
UT WOS:000628271900001
PM 33807522
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Zhou, ZY
   Ren, LW
   Zhan, P
   Yang, HY
   Chai, DD
   Yu, ZW
AF Zhou, Zi-yu
   Ren, Li-wei
   Zhan, Ping
   Yang, Han-yan
   Chai, Dan-dan
   Yu, Zhi-wen
TI Metformin exerts glucose-lowering action in high-fat fed mice via
   attenuating endotoxemia and enhancing insulin signaling
SO ACTA PHARMACOLOGICA SINICA
LA English
DT Article
DE metformin; diabetes; high-fat fed mice; gut microbiota; LPS;
   endotoxemia; AMPK; PTEN; Nrf2
ID GUT MICROBIOTA; INFLAMMATORY RESPONSE; OXIDATIVE STRESS;
   DOWN-REGULATION; PROTEIN-KINASE; CROSS-TALK; RESISTANCE; DIET; OBESITY;
   ACTIVATION
AB Aim: Accumulating evidence shows that lipopolysaccharides (LPS) derived from gut gram-negative bacteria can be absorbed, leading to endotoxemia that triggers systemic inflammation and insulin resistance. In this study we examined whether metformin attenuated endotoxemia, thus improving insulin signaling in high-fat diet fed mice.
   Methods: Mice were fed a high-fat diet for 18 weeks to induce insulin resistance. One group of the mice was treated with oral metformin (100 mg.kg(-1).d(-1)) for 4 weeks. Another group was treated with LPS (50 mu g.kg(-1).d(-1), sc) for 5 days followed by the oral metformin for 10 d. Other two groups received a combination of antibiotics for 7 d or a combination of antibiotics for 7 d followed by the oral metformin for 4 weeks, respectively. Glucose metabolism and insulin signaling in liver and muscle were evaluated, the abundance of gut bacteria, gut permeability and serum LPS levels were measured.
   Results: In high-fat fed mice, metformin restored the tight junction protein occludin-1 levels in gut, reversed the elevated gut permeability and serum LPS levels, and increased the abundance of beneficial bacteria Lactobacillus and Akkermansia muciniphila. Metformin also increased PKB Ser473 and AMPK T172 phosphorylation, decreased MDA contents and redox-sensitive PTEN protein levels, activated the anti-oxidative Nrf2 system, and increased I kappa B alpha in liver and muscle of the mice. Treatment with exogenous LPS abolished the beneficial effects of metformin on glucose metabolism, insulin signaling and oxidative stress in liver and muscle of the mice. Treatment with antibiotics alone produced similar effects as metformin did. Furthermore, the beneficial effects of antibiotics were addictive to those of metformin.
   Conclusion: Metformin administration attenuates endotoxemia and enhances insulin signaling in high-fat fed mice, which contributes to its anti-diabetic effects.
C1 [Zhou, Zi-yu; Ren, Li-wei; Zhan, Ping; Yang, Han-yan; Chai, Dan-dan; Yu, Zhi-wen] Fujian Univ Tradit Chinese Med, Fujian Key Lab Chinese Mat Med, Biomed Drug R&D Ctr, Fuzhou 350122, Peoples R China.
C3 Fujian University of Traditional Chinese Medicine
RP Yu, ZW (通讯作者)，Fujian Univ Tradit Chinese Med, Fujian Key Lab Chinese Mat Med, Biomed Drug R&D Ctr, Fuzhou 350122, Peoples R China.
EM yuzhiwen@yahoo.com
FU National Natural Science Foundation of China [81270886]
FX This work was supported by a National Natural Science Foundation of
   China (No 81270886 to Zhi-wen YU).
CR Ashabi G, 2015, METAB BRAIN DIS, V30, P747, DOI 10.1007/s11011-014-9632-2
   Backhed F, 2007, P NATL ACAD SCI USA, V104, P979, DOI 10.1073/pnas.0605374104
   Moreira APB, 2012, BRIT J NUTR, V108, P801, DOI 10.1017/S0007114512001213
   Bradlow HL, 2014, HORM MOL BIOL CLIN I, V17, P53, DOI 10.1515/hmbci-2013-0063
   Cabreiro F, 2013, EMBO MOL MED, V5, P1300, DOI 10.1002/emmm.201100972
   Cabreiro F, 2013, CELL, V153, P228, DOI 10.1016/j.cell.2013.02.035
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   Carvalho BM, 2012, DIABETOLOGIA, V55, P2823, DOI 10.1007/s00125-012-2648-4
   Carvalho BM, 2013, MEDIAT INFLAMM, V2013, DOI 10.1155/2013/986734
   Cheng AS, 2012, J AGR FOOD CHEM, V60, P9180, DOI 10.1021/jf302831d
   Dhungana S, 2009, MOL CELL PROTEOMICS, V8, P201, DOI 10.1074/mcp.M800286-MCP200
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Foretz M, 2010, J CLIN INVEST, V120, P2355, DOI 10.1172/JCI40671
   He HJ, 2012, WORLD J DIABETES, V3, P94, DOI 10.4239/wjd.v3.i5.94
   Hou RR, 2010, APOPTOSIS, V15, P877, DOI 10.1007/s10495-010-0510-z
   Houstis N, 2006, NATURE, V440, P944, DOI 10.1038/nature04634
   Kim J, 2014, J BIOL CHEM, V289, P23246, DOI 10.1074/jbc.M114.577908
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Napolitano A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100778
   Okamura H, 2007, CELL BIOL INT, V31, P119, DOI 10.1016/j.cellbi.2006.09.014
   PAPPO I, 1991, J SURG RES, V51, P106, DOI 10.1016/0022-4804(91)90078-Z
   Prajapati B, 2014, CURR DIABETES REV, V10, P190, DOI 10.2174/1573399810666140515112609
   Ramakrishna BS, 2013, J GASTROEN HEPATOL, V28, P9, DOI 10.1111/jgh.12294
   Rao J, 2015, AM J TRANSPLANT, V15, P76, DOI 10.1111/ajt.12954
   REAVEN GM, 1995, PHYSIOL REV, V75, P473, DOI 10.1152/physrev.1995.75.3.473
   Rojo AI, 2014, ANTIOXID REDOX SIGN, V21, P2498, DOI 10.1089/ars.2014.5843
   Shalaby Mohamed A Fouad, 2013, World J Gastrointest Pharmacol Ther, V4, P28, DOI 10.4292/wjgpt.v4.i2.28
   Shaw RJ, 2005, SCIENCE, V310, P1642, DOI 10.1126/science.1120781
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Song P, 2007, CIRCULATION, V116, P1585, DOI 10.1161/CIRCULATIONAHA.107.716498
   Stephenne X, 2011, DIABETOLOGIA, V54, P3101, DOI 10.1007/s00125-011-2311-5
   Tadie JM, 2012, MOL MED, V18, P659, DOI 10.2119/molmed.2011.00401
   Tan Y, 2011, DIABETES, V60, P625, DOI 10.2337/db10-1164
   Thimmulappa RK, 2006, BIOCHEM BIOPH RES CO, V351, P883, DOI 10.1016/j.bbrc.2006.10.102
   Tomasi ML, 2014, FREE RADICAL BIO MED, V68, P148, DOI 10.1016/j.freeradbiomed.2013.11.018
   Udayappan SD, 2014, CLIN EXP IMMUNOL, V177, P24, DOI 10.1111/cei.12293
   Uruno A, 2015, ARCH BIOCHEM BIOPHYS, V566, P76, DOI 10.1016/j.abb.2014.12.012
   Wang LF, 2013, CARDIOVASC TOXICOL, V13, P338, DOI 10.1007/s12012-013-9214-2
   Yang Y, 2014, OXID MED CELL LONGEV, V2014, DOI 10.1155/2014/145641
   Yu Z, 2011, DIABETOLOGIA, V54, P922, DOI 10.1007/s00125-010-2001-8
   Yu ZT, 2004, BIOTECHNIQUES, V36, P808, DOI 10.2144/04365ST04
NR 41
TC 57
Z9 60
U1 2
U2 23
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1671-4083
EI 1745-7254
J9 ACTA PHARMACOL SIN
JI Acta Pharmacol. Sin.
PD AUG
PY 2016
VL 37
IS 8
BP 1063
EP 1075
DI 10.1038/aps.2016.21
PG 13
WC Chemistry, Multidisciplinary; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Pharmacology & Pharmacy
GA DS6XR
UT WOS:000380927200006
PM 27180982
OA Green Published, Bronze
DA 2023-06-08
ER

PT J
AU Lee, SE
   Choi, Y
   Jun, JE
   Lee, YB
   Jin, SM
   Hur, KY
   Ko, GP
   Lee, MK
AF Lee, Seung-Eun
   Choi, Yongbin
   Jun, Ji Eun
   Lee, You-Bin
   Jin, Sang-Man
   Hur, Kyu Yeon
   Ko, Gwang Pyo
   Lee, Moon-Kyu
TI Additional Effect of Dietary Fiber in Patients with Type 2 Diabetes
   Mellitus Using Metformin and Sulfonylurea: An Open-Label, Pilot Trial
SO DIABETES & METABOLISM JOURNAL
LA English
DT Article
DE Diabetes mellitus; type 2; Dietary fiber; Metformin; Microbiota;
   Sulfonylurea compounds
ID CHAIN FATTY-ACIDS; INSULIN SENSITIVITY; GUT MICROBIOTA; INTESTINAL
   MICROBIOTA; GLUCOSE; INDIVIDUALS; RESISTANCE; INDEX
AB Background: Metformin, sulfonylurea, and dietary fiber are known to affect gut microbiota in patients with type 2 diabetes mellitus (T2DM). This open and single-arm pilot trial investigated the effects of the additional use of fiber on glycemic parameters, insulin, incretins, and microbiota in patients with T2DM who had been treated with metformin and sulfonylurea.
   Methods: Participants took fiber for 4 weeks and stopped for the next 4 weeks. Glycemic parameters, insulin, incretins during mixed-meal tolerance test (MMTT), lipopolysaccharide (LPS) level, and fecal microbiota were analyzed at weeks 0, 4, and 8. The first tertile of difference in glucose area under the curve during MMTT between weeks 0 and 4 was defined as 'responders' and the third as 'nonresponders', respectively.
   Results: In all 10 participants, the peak incretin levels during MMTT were higher and LPS were lower at week 4 as compared with at baseline. While the insulin sensitivity of the 'responders' increased at week 4, that of the 'nonresponders' showed opposite results. However, the results were not statistically significant. In all participants, metabolically unfavorable microbiota decreased at week 4 and were restored at week 8. At baseline, metabolically hostile bacteria were more abundant in the 'nonresponders.' In 'responders', Roseburia inteslinalis increased at week 4.
   Conclusion: While dietary fiber did not induce additional changes in glycemic parameters, it showed a trend of improvement in insulin sensitivity in 'responders', Even if patients are already receiving diabetes treatment, the additional administration of fiber can lead to additional benefits in the treatment of diabetes.
C1 [Lee, Seung-Eun; Jin, Sang-Man; Hur, Kyu Yeon; Lee, Moon-Kyu] Sungkyunkwan Univ, Samsung Med Ctr, Dept Med, Div Endocrinol & Metab,Sch Med, 81 Irwon Ro, Seoul 06351, South Korea.
   [Choi, Yongbin; Ko, Gwang Pyo] Seoul Natl Univ, Grad Sch Publ Hlth, Dept Environm Hlth Sci, Seoul, South Korea.
   [Jun, Ji Eun] Kyung Hee Univ, Kyung Hee Univ Hosp Gangdong, Dept Endocrinol & Metab, Sch Med, Seoul, South Korea.
   [Lee, You-Bin] Korea Univ, Guro Hosp, Dept Med, Div Endocrinol & Metab,Coll Med, Seoul, South Korea.
C3 Sungkyunkwan University (SKKU); Samsung Medical Center; Seoul National
   University (SNU); Kyung Hee University; Kyung Hee University Hospital;
   Korea University; Korea University Medicine (KU Medicine)
RP Lee, MK (通讯作者)，Sungkyunkwan Univ, Samsung Med Ctr, Dept Med, Div Endocrinol & Metab,Sch Med, 81 Irwon Ro, Seoul 06351, South Korea.
EM leemk@skku.edu
RI Jin, Sang-Man/AFO-5933-2022
OI Jin, Sang-Man/0000-0001-5929-3627; Lee, You-Bin/0000-0003-4058-1738;
   Lee, Seung-Eun/0000-0001-5785-1891
CR Abutair AS, 2016, NUTR J, V15, DOI 10.1186/s12937-016-0207-4
   Bajorek SA, 2010, ANN PHARMACOTHER, V44, P1786, DOI 10.1345/aph.1P347
   Brown AJ, 2003, J BIOL CHEM, V278, P11312, DOI 10.1074/jbc.M211609200
   Edgar RC, 2011, BIOINFORMATICS, V27, P2194, DOI 10.1093/bioinformatics/btr381
   Esteve E, 2011, CURR OPIN CLIN NUTR, V14, P483, DOI 10.1097/MCO.0b013e328348c06d
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Gibb RD, 2015, AM J CLIN NUTR, V102, P1604, DOI 10.3945/ajcn.115.106989
   Grabitske HA, 2008, J AM DIET ASSOC, V108, P1677, DOI 10.1016/j.jada.2008.07.010
   Hall Micki, 2012, Consult Pharm, V27, P513, DOI 10.4140/TCP.n.2012.513
   Han JL, 2014, WORLD J GASTROENTERO, V20, P17737, DOI 10.3748/wjg.v20.i47.17737
   Huo TG, 2015, BIOMED CHROMATOGR, V29, P115, DOI 10.1002/bmc.3247
   Hur KY, 2015, DIABETES METAB J, V39, P198, DOI 10.4093/dmj.2015.39.3.198
   Hur M, 2011, APPL ENVIRON MICROB, V77, P7611, DOI 10.1128/AEM.06102-11
   Kalyani RR, 2018, DIABETES CARE, V41, pS3, DOI [10.2337/dc18-Sppc01, 10.2337/dc18-SPPC01]
   Kasubuchi M, 2015, NUTRIENTS, V7, P2839, DOI 10.3390/nu7042839
   Katz A, 2000, J CLIN ENDOCR METAB, V85, P2402, DOI 10.1210/jc.85.7.2402
   Kim OS, 2012, INT J SYST EVOL MICR, V62, P716, DOI 10.1099/ijs.0.038075-0
   Korean Diabetes Association, 2018, DIAB FACT SHEET KOR
   Kovatcheva-Datchary P, 2015, CELL METAB, V22, P971, DOI 10.1016/j.cmet.2015.10.001
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Levy JC, 1998, DIABETES CARE, V21, P2191, DOI 10.2337/diacare.21.12.2191
   Mardinoglu A, 2016, CELL METAB, V23, P10, DOI 10.1016/j.cmet.2015.12.012
   Matsuda M, 1999, DIABETES CARE, V22, P1462, DOI 10.2337/diacare.22.9.1462
   Montandon SA, 2017, GENES-BASEL, V8, DOI 10.3390/genes8100250
   Napolitano A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100778
   Neyrinck AM, 2012, J NUTR BIOCHEM, V23, P51, DOI 10.1016/j.jnutbio.2010.10.008
   PASTORS JG, 1991, AM J CLIN NUTR, V53, P1431, DOI 10.1093/ajcn/53.6.1431
   Pluznick JL, 2014, GUT MICROBES, V5, P202, DOI 10.4161/gmic.27492
   Post RE, 2012, J AM BOARD FAM MED, V25, P16, DOI 10.3122/jabfm.2012.01.110148
   Puddu A, 2014, MEDIAT INFLAMM, V2014, DOI 10.1155/2014/162021
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Raso GM, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0068626
   Roelofsen H, 2010, BENEF MICROBES, V1, P433, DOI 10.3920/BM2010.0028
   Romeo GR, 2012, ARTERIOSCL THROM VAS, V32, P1771, DOI 10.1161/ATVBAHA.111.241869
   Segata N, 2011, GENOME BIOL, V12, DOI 10.1186/gb-2011-12-6-r60
   Vrieze A, 2012, GASTROENTEROLOGY, V143, P913, DOI 10.1053/j.gastro.2012.06.031
   Weickert MO, 2005, DIABETOLOGIA, V48, P2343, DOI 10.1007/s00125-005-1941-x
   Woting A, 2016, NUTRIENTS, V8, DOI 10.3390/nu8040202
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
NR 39
TC 8
Z9 10
U1 1
U2 4
PU KOREAN DIABETES ASSOC
PI SEOUL
PA 101-2104, LOTTE CASTLE PRES, 109 MAPO-DAERO, MAPO-GU, SEOUL, 04146,
   SOUTH KOREA
SN 2233-6079
EI 2233-6087
J9 DIABETES METAB J
JI Diabetes Metab. J.
PD AUG
PY 2019
VL 43
IS 4
BP 422
EP 431
DI 10.4093/dmj.2018.0090
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA IS5XL
UT WOS:000482226400005
PM 31237126
OA gold, Green Published, Green Submitted
DA 2023-06-08
ER

PT J
AU Bauer, PV
   Duca, FA
   Waise, TMZ
   Rasmussen, BA
   Abraham, MA
   Dranse, HJ
   Puri, A
   O'Brien, CA
   Lam, TKT
AF Bauer, Paige V.
   Duca, Frank A.
   Waise, T. M. Zaved
   Rasmussen, Brittany A.
   Abraham, Mona A.
   Dranse, Helen J.
   Puri, Akshita
   O'Brien, Catherine A.
   Lam, Tony K. T.
TI Metformin Alters Upper Small Intestinal Microbiota that Impact a
   Glucose-SGLT1-Sensing Glucoregulatory Pathway
SO CELL METABOLISM
LA English
DT Article
ID GLUCAGON-LIKE PEPTIDE-1; LOWERS GLUCOSE-PRODUCTION; INSULIN SENSITIVITY;
   AKKERMANSIA-MUCINIPHILA; DIABETES PREVENTION; INCRETIN HORMONE; GLP-1
   SECRETION; PROTEIN-KINASE; ABSORPTION; INHIBITION
AB The gut microbiota alters energy homeostasis. In parallel, metformin regulates upper small intestinal sodium glucose cotransporter-1 (SGLT1), but whether changes of the microbiota or SGLT1-dependent pathways in the upper small intestine mediate metformin action is unknown. Here we report that upper small intestinal glucose sensing triggers an SGLT1-dependent pathway to lower glucose production in rodents. High-fat diet (HFD) feeding reduces glucose sensing and SGLT1 expression in the upper small intestine. Upper small intestinal metformin treatment restores SGLT1 expression and glucose sensing while shifting the upper small intestinal microbiota partly by increasing the abundance of Lactobacillus. Transplantation of upper small intestinal microbiota from metformin-treated HFD rats to the upper small intestine of untreated HFD rats also increases the upper small intestinal abundance of Lactobacillus and glucose sensing via an upregulation of SGLT1 expression. Thus, we demonstrate that metformin alters upper small intestinal microbiota and impacts a glucose-SGLT1-sensing glucoregulatory pathway.
C1 [Bauer, Paige V.; Duca, Frank A.; Waise, T. M. Zaved; Rasmussen, Brittany A.; Abraham, Mona A.; Dranse, Helen J.; Lam, Tony K. T.] UHN, Toronto Gen Hosp, Res Inst, Toronto, ON M5G 1L7, Canada.
   [Bauer, Paige V.; Rasmussen, Brittany A.; Abraham, Mona A.; O'Brien, Catherine A.; Lam, Tony K. T.] Univ Toronto, Dept Physiol, Toronto, ON M5S 1A8, Canada.
   [Lam, Tony K. T.] Univ Toronto, Dept Med, Toronto, ON M5S 1A8, Canada.
   [Puri, Akshita; O'Brien, Catherine A.] UHN, Princess Margaret Canc Ctr, Toronto, ON M5G 2M9, Canada.
   [O'Brien, Catherine A.] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON M5S 1A8, Canada.
   [Lam, Tony K. T.] Univ Toronto, Banting & Best Diabet Ctr, Toronto, ON M5G 2C4, Canada.
   [Duca, Frank A.] Univ Arizona, Sch Anim & Comparat Biomed Sci, Tucson, AZ 85721 USA.
C3 University of Toronto; University Health Network Toronto; Toronto
   General Hospital; University of Toronto; University of Toronto;
   University of Toronto; University Health Network Toronto; Princess
   Margaret Cancer Centre; University of Toronto; University of Toronto;
   University of Arizona
RP Lam, TKT (通讯作者)，UHN, Toronto Gen Hosp, Res Inst, Toronto, ON M5G 1L7, Canada.; Lam, TKT (通讯作者)，Univ Toronto, Dept Physiol, Toronto, ON M5S 1A8, Canada.; Lam, TKT (通讯作者)，Univ Toronto, Dept Med, Toronto, ON M5S 1A8, Canada.; Lam, TKT (通讯作者)，Univ Toronto, Banting & Best Diabet Ctr, Toronto, ON M5G 2C4, Canada.
EM tony.lam@uhnres.utoronto.ca
RI WAISE, T M ZAVED/CAG-2483-2022
OI WAISE, T M ZAVED/0000-0002-0205-258X; O'Brien,
   Catherine/0000-0003-0682-3879
FU Canadian Institutes of Health Research (CIHR) Foundation [FDN-143204];
   Ontario Graduate Scholarship; Banting and Best Diabetes Centre; BBDC;
   CIHR; Diabetes Canada
FX The authors are grateful to P. Wang for assistance. This work was funded
   by a Canadian Institutes of Health Research (CIHR) Foundation Grant to
   T.K.T.L. (FDN-143204). P.V.B. is supported by an Ontario Graduate
   Scholarship and by a Banting and Best Diabetes Centre graduate
   studentship. F.A.D. was a Banting Fellow. T.M.Z.W. is supported by a
   BBDC post-doctoral fellowship. B.A.R. was a Vanier scholar. M.A.A. is
   supported by a CIHR Doctoral award. H.J.D. is supported by postdoctoral
   fellowships from the CIHR and Diabetes Canada. T.K.T.L. holds the John
   Kitson McIvor (1915-1942) Endowed Chair in Diabetes Research and the
   Canada Research Chair in Obesity.
CR ANDREWS NJ, 1983, GUT, V24, P326, DOI 10.1136/gut.24.4.326
   Asemi Z, 2013, ANN NUTR METAB, V63, P1, DOI 10.1159/000349922
   Atuma C, 2001, AM J PHYSIOL-GASTR L, V280, pG922, DOI 10.1152/ajpgi.2001.280.5.G922
   Aziz AA, 2009, J NUTR, V139, P1881, DOI 10.3945/jn.109.110650
   Bailey CJ, 2008, DIABETOLOGIA, V51, P1552, DOI 10.1007/s00125-008-1053-5
   BAILEY CJ, 1994, BRIT J PHARMACOL, V112, P671, DOI 10.1111/j.1476-5381.1994.tb13128.x
   BAILEY CJ, 1992, BRIT J PHARMACOL, V105, P1009, DOI 10.1111/j.1476-5381.1992.tb09093.x
   Balakumar M., 2016, EUR J NUTR
   Bartram AK, 2011, APPL ENVIRON MICROB, V77, P3846, DOI 10.1128/AEM.02772-10
   Breen DM, 2012, NAT MED, V18, P950, DOI 10.1038/nm.2745
   Breen DM, 2011, DIABETES, V60, P3148, DOI 10.2337/db11-0852
   BRUBAKER PL, 1991, ENDOCRINOLOGY, V128, P3175, DOI 10.1210/endo-128-6-3175
   Buse JB, 2016, DIABETES CARE, V39, P198, DOI 10.2337/dc15-0488
   Campbell JE, 2013, CELL METAB, V17, P819, DOI 10.1016/j.cmet.2013.04.008
   Cani PD, 2006, DIABETES, V55, P1484, DOI 10.2337/db05-1360
   Cani PD, 2004, BRIT J NUTR, V92, P521, DOI 10.1079/BJN20041225
   Caporaso JG, 2010, NAT METHODS, V7, P335, DOI 10.1038/nmeth.f.303
   Cariou B, 2015, EXPERT OPIN INV DRUG, V24, P1647, DOI 10.1517/13543784.2015.1100361
   CASPARY WF, 1971, DIABETOLOGIA, V7, P379, DOI 10.1007/BF01219474
   Chambers AP, 2017, CELL METAB, V25, P927, DOI 10.1016/j.cmet.2017.02.008
   Charrier JA, 2013, OBESITY, V21, P2350, DOI 10.1002/oby.20362
   Cheung GWC, 2009, CELL METAB, V10, P99, DOI 10.1016/j.cmet.2009.07.005
   Chisholm C, 2002, AM J PHYSIOL-ENDOC M, V283, pE311, DOI 10.1152/ajpendo.00434.2001
   COHEN AM, 1977, METABOLISM, V26, P17, DOI 10.1016/0026-0495(77)90123-8
   Cote CD, 2015, NAT MED, V21, P498, DOI 10.1038/nm.3821
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Derrien M, 2011, FRONT MICROBIOL, V2, DOI 10.3389/fmicb.2011.00166
   DeSantis TZ, 2006, APPL ENVIRON MICROB, V72, P5069, DOI 10.1128/AEM.03006-05
   Duca FA, 2015, CELL METAB, V22, P367, DOI 10.1016/j.cmet.2015.07.003
   Duca FA, 2015, NAT MED, V21, P506, DOI 10.1038/nm.3787
   Ejtahed HS, 2012, NUTRITION, V28, P539, DOI 10.1016/j.nut.2011.08.013
   El Aidy S, 2013, GUT, V62, P1306, DOI 10.1136/gutjnl-2011-301955
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Florez H, 2010, POSTGRAD MED, V122, P112, DOI 10.3810/pgm.2010.03.2128
   Florez JC, 2006, NEW ENGL J MED, V355, P241, DOI 10.1056/NEJMoa062418
   Foretz M, 2010, J CLIN INVEST, V120, P2355, DOI 10.1172/JCI40671
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Fredborg M, 2012, J ANIM SCI, V90, P10, DOI 10.2527/jas.53792
   Freeman SL, 2006, AM J PHYSIOL-GASTR L, V291, pG439, DOI 10.1152/ajpgi.00079.2006
   Fullerton MD, 2013, NAT MED, V19, P1649, DOI 10.1038/nm.3372
   Gerspach AC, 2011, AM J PHYSIOL-ENDOC M, V301, pE317, DOI 10.1152/ajpendo.00077.2011
   Gorboulev V, 2012, DIABETES, V61, P187, DOI 10.2337/db11-1029
   Greenwood DC, 2014, BRIT J NUTR, V112, P725, DOI 10.1017/S0007114514001329
   Gribble FM, 2003, DIABETES, V52, P1147, DOI 10.2337/diabetes.52.5.1147
   Gu SH, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0074957
   Hansen L, 2000, AM J PHYSIOL-ENDOC M, V278, pE1010, DOI 10.1152/ajpendo.2000.278.6.E1010
   Holst JJ, 2005, DIABETOLOGIA, V48, P612, DOI 10.1007/s00125-005-1705-7
   Iakoubov R, 2011, ENDOCRINOLOGY, V152, P1244, DOI 10.1210/en.2010-1352
   Ihaka R., 1996, J COMPUTATIONAL GRAP, V5, P299, DOI [DOI 10.1080/10618600.1996.10474713, 10.2307/1390807]
   Jang HJ, 2007, P NATL ACAD SCI USA, V104, P15069, DOI 10.1073/pnas.0706890104
   Jensen JB, 2016, DIABETES, V65, P1724, DOI 10.2337/db16-0032
   Koffert JP, 2017, DIABETES RES CLIN PR, V131, P208, DOI 10.1016/j.diabres.2017.07.015
   Kok NN, 1998, J NUTR, V128, P1099, DOI 10.1093/jn/128.7.1099
   Krieger JP, 2016, DIABETES, V65, P34, DOI 10.2337/db15-0973
   Kuhre RE, 2015, DIABETES, V64, P370, DOI 10.2337/db14-0807
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Lenzen S, 1996, BIOCHEM PHARMACOL, V51, P893, DOI 10.1016/0006-2952(95)02243-0
   Little TJ, 2006, AM J PHYSIOL-ENDOC M, V291, pE647, DOI 10.1152/ajpendo.00099.2006
   LORCH E, 1971, DIABETOLOGIA, V7, P195, DOI 10.1007/BF01212553
   LOVE MI, 2014, GENOME BIOL, V15, DOI DOI 10.1186/S13059-014-0550-8
   Ma J, 2010, BRIT J NUTR, V104, P803, DOI 10.1017/S0007114510001327
   Madiraju AK, 2014, NATURE, V510, P542, DOI 10.1038/nature13270
   Maida A, 2011, DIABETOLOGIA, V54, P339, DOI 10.1007/s00125-010-1937-z
   Margolskee RF, 2007, P NATL ACAD SCI USA, V104, P15075, DOI 10.1073/pnas.0706678104
   Masella AP, 2012, BMC BIOINFORMATICS, V13, DOI 10.1186/1471-2105-13-31
   Miller RA, 2013, NATURE, V494, P256, DOI 10.1038/nature11808
   Moeller, 2016, VARIOUS R PROGRAMMIN
   Morgan K, 2004, J BIOL CHEM, V279, P31139, DOI 10.1074/jbc.M400458200
   Moriya R, 2009, AM J PHYSIOL-ENDOC M, V297, pE1358, DOI 10.1152/ajpendo.00412.2009
   Neyrinck AM, 2012, NUTR DIABETES, V2, DOI 10.1038/nutd.2011.24
   O'Connor L, 2015, DIABETOLOGIA, V58, P1474, DOI 10.1007/s00125-015-3572-1
   Oguma T, 2015, J PHARMACOL EXP THER, V354, P279, DOI 10.1124/jpet.115.225508
   Oh JR, 2010, AM J ROENTGENOL, V195, P1404, DOI 10.2214/AJR.10.4663
   Owen MR, 2000, BIOCHEM J, V348, P607, DOI 10.1042/0264-6021:3480607
   Parker HE, 2012, DIABETOLOGIA, V55, P2445, DOI 10.1007/s00125-012-2585-2
   PENICAUD L, 1989, BIOCHEM J, V262, P881, DOI 10.1042/bj2620881
   Pepino MY, 2013, DIABETES CARE, V36, P2530, DOI 10.2337/dc12-2221
   Perry RJ, 2016, NATURE, V534, P213, DOI 10.1038/nature18309
   Pilichiewicz AN, 2007, AM J PHYSIOL-ENDOC M, V293, pE743, DOI 10.1152/ajpendo.00159.2007
   Ploner A, 2015, HEATPLUS HEATMAPS RO
   Plovier H, 2017, NAT MED, V23, P107, DOI 10.1038/nm.4236
   Rasmussen BA, 2012, GASTROENTEROLOGY, V142, P834, DOI 10.1053/j.gastro.2011.12.053
   Reijnders D, 2016, CELL METAB, V24, P63, DOI [10.1016/j.cmet.2016.06.016, 10.1016/j.cmet.2016.07.008]
   Reimann F, 2008, CELL METAB, V8, P532, DOI 10.1016/j.cmet.2008.11.002
   Richards P, 2016, PEPTIDES, V77, P21, DOI 10.1016/j.peptides.2015.06.006
   Richards P, 2014, DIABETES, V63, P1224, DOI 10.2337/db13-1440
   Scherer T, 2012, J BIOL CHEM, V287, P33061, DOI 10.1074/jbc.M111.307348
   Scholtka B, 1999, GUT, V44, P490, DOI 10.1136/gut.44.4.490
   Schwartz GJ, 2008, CELL METAB, V8, P281, DOI 10.1016/j.cmet.2008.08.005
   Shaw RJ, 2005, SCIENCE, V310, P1642, DOI 10.1126/science.1120781
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Sladek R, 2007, NATURE, V445, P881, DOI 10.1038/nature05616
   Stanhope KL, 2009, J CLIN INVEST, V119, P1322, DOI 10.1172/JCI37385
   Stepensky D, 2002, DRUG METAB DISPOS, V30, P861, DOI 10.1124/dmd.30.8.861
   Stepensky D, 2001, J CONTROL RELEASE, V71, P107, DOI 10.1016/S0168-3659(00)00374-6
   Taher J, 2014, MOL METAB, V3, P823, DOI 10.1016/j.molmet.2014.09.005
   Tappenden KA, 1998, AM J CLIN NUTR, V68, P118, DOI 10.1093/ajcn/68.1.118
   Thaler JP, 2012, J CLIN INVEST, V122, P153, DOI 10.1172/JCI59660
   TUCKER GT, 1981, BRIT J CLIN PHARMACO, V12, P235
   Tuomilehto J, 2001, NEW ENGL J MED, V344, P1343, DOI 10.1056/NEJM200105033441801
   Vahl TP, 2007, ENDOCRINOLOGY, V148, P4965, DOI 10.1210/en.2006-0153
   Vallon V, 2015, ANNU REV MED, V66, P255, DOI 10.1146/annurev-med-051013-110046
   Vardarli I, 2014, DIABETES, V63, P663, DOI 10.2337/db13-0805
   Vazquez-Baeza Y, 2013, GIGASCIENCE, V2, DOI 10.1186/2047-217X-2-16
   Vrhovac Ivana, 2015, Pflugers Arch, V467, P1881, DOI 10.1007/s00424-014-1619-7
   Vrieze A, 2012, GASTROENTEROLOGY, V143, P913, DOI 10.1053/j.gastro.2012.06.031
   Wang J, 2007, DIABETOLOGIA, V50, P1192, DOI 10.1007/s00125-007-0656-6
   Wang PYT, 2008, NATURE, V452, P1012, DOI 10.1038/nature06852
   Wang Q, 2007, APPL ENVIRON MICROB, V73, P5261, DOI 10.1128/AEM.00062-07
   Whelan Fiona J, 2014, Ann Am Thorac Soc, V11, P513, DOI 10.1513/AnnalsATS.201310-351OC
   Wickham H, 2009, USE R, P1, DOI 10.1007/978-0-387-98141-3
   Wirth R, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0110440
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Wu TZ, 2012, AM J CLIN NUTR, V95, P78, DOI 10.3945/ajcn.111.021543
   Xiong T, 2020, SENSOR ACTUAT B-CHEM, V304, DOI [10.1126/scitranslmed.3009124, 10.1016/j.snb.2019.127310]
   Yadav H, 2007, NUTRITION, V23, P62, DOI 10.1016/j.nut.2006.09.002
   Yang R, 2011, INT J OBESITY, V35, P217, DOI 10.1038/ijo.2010.128
   Ye YZ, 2010, IEEE INT C BIOINFORM, P153, DOI 10.1109/BIBM.2010.5706555
   Zadeh-Tahmasebi M, 2016, J BIOL CHEM, V291, P8816, DOI 10.1074/jbc.M116.718460
   Zhang X, 2015, SCI REP-UK, V5, DOI 10.1038/srep09803
   Zhou GC, 2001, J CLIN INVEST, V108, P1167, DOI 10.1172/JCI200113505
   Zhou J, 2008, AM J PHYSIOL-ENDOC M, V295, pE1160, DOI 10.1152/ajpendo.90637.2008
   Zhou ZY, 2016, ACTA PHARMACOL SIN, V37, P1063, DOI 10.1038/aps.2016.21
NR 123
TC 140
Z9 156
U1 3
U2 99
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
SN 1550-4131
EI 1932-7420
J9 CELL METAB
JI Cell Metab.
PD JAN 9
PY 2018
VL 27
IS 1
BP 101
EP +
DI 10.1016/j.cmet.2017.09.019
PG 22
WC Cell Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Endocrinology & Metabolism
GA FS2EY
UT WOS:000419592800011
PM 29056513
OA Bronze
DA 2023-06-08
ER

PT J
AU Chow, E
   Yang, AM
   Chung, CHL
   Chan, JCN
AF Chow, Elaine
   Yang, Aimin
   Chung, Colin H. L.
   Chan, Juliana C. N.
TI A Clinical Perspective of the Multifaceted Mechanism of Metformin in
   Diabetes, Infections, Cognitive Dysfunction, and Cancer
SO PHARMACEUTICALS
LA English
DT Review
DE metformin; diabetes; mechanisms; anticancer action; infections;
   cognition; cardioprotection
ID ALL-CAUSE MORTALITY; CHRONIC KIDNEY-DISEASE; FATTY LIVER-DISEASE;
   OUTCOME PROGRESSION TRIAL; CARDIOVASCULAR-DISEASE; GLYCEMIC CONTROL;
   RETROSPECTIVE COHORT; ENDOTHELIAL FUNCTION; SEVERE HYPOGLYCEMIA;
   OLDER-ADULTS
AB In type 2 diabetes, ecological and lifecourse factors may interact with the host microbiota to influence expression of his/her genomes causing perturbation of interconnecting biological pathways with diverse clinical course. Metformin is a plant-based or plant-derived medicinal product used for the treatment of type 2 diabetes for over 60 years and is an essential drug listed by the World Health Organization. By reducing mitochondrial oxidative phosphorylation and adenosine triphosphate (ATP) production, metformin increased AMP (adenosine monophosphate)-activated protein kinase (AMPK) activity and altered cellular redox state with reduced glucagon activity, endogenous glucose production, lipogenesis, and protein synthesis. Metformin modulated immune response by directly reducing neutrophil to lymphocyte ratio and improving the phagocytic function of immune cells. By increasing the relative abundance of mucin-producing and short-chain-fatty-acid-producing gut microbes, metformin further improved the host inflammatory and metabolic milieu. Experimentally, metformin promoted apoptosis and reduced proliferation of cancer cells by reducing their oxygen consumption and modulating the microenvironment. Both clinical and mechanistic studies support the pluripotent effects of metformin on reducing cardiovascular-renal events, infection, cancer, cognitive dysfunction, and all-cause death in type 2 diabetes, making this low-cost medication a fundamental therapy for individualization of other glucose-lowering drugs in type 2 diabetes. Further research into the effects of metformin on cognitive function, infection and cancer, especially in people without diabetes, will provide new insights into the therapeutic value of metformin in our pursuit of prevention and treatment of ageing-related as well as acute and chronic diseases beyond diabetes.
C1 [Chow, Elaine; Yang, Aimin; Chung, Colin H. L.; Chan, Juliana C. N.] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Med & Therapeut, Hong Kong 999077, Peoples R China.
   [Chow, Elaine; Yang, Aimin; Chan, Juliana C. N.] Chinese Univ Hong Kong, Prince Wales Hosp, Hong Kong Inst Diabet & Obes, Hong Kong 999077, Peoples R China.
   [Chow, Elaine] Chinese Univ Hong Kong, Prince Wales Hosp, Phase Clin Trial Ctr 1, Hong Kong 999077, Peoples R China.
C3 Chinese University of Hong Kong; Prince of Wales Hospital; Chinese
   University of Hong Kong; Prince of Wales Hospital; Chinese University of
   Hong Kong; Prince of Wales Hospital
RP Chan, JCN (通讯作者)，Chinese Univ Hong Kong, Prince Wales Hosp, Dept Med & Therapeut, Hong Kong 999077, Peoples R China.; Chan, JCN (通讯作者)，Chinese Univ Hong Kong, Prince Wales Hosp, Hong Kong Inst Diabet & Obes, Hong Kong 999077, Peoples R China.
EM e.chow@cuhk.edu.hk; aiminyang@cuhk.edu.hk; 1155125450@link.cuhk.edu.hk;
   jchan@cuhk.edu.hk
RI Chow, Elaine/HJB-2197-2022; Yang, Aimin/D-8344-2015; Chan,
   Juliana/B-7918-2016
OI Chow, Elaine/0000-0002-4147-3387; Chung, Ho Lam
   Colin/0000-0003-2821-6965; Yang, Aimin/0000-0003-2968-1762; Chan,
   Juliana/0000-0003-1325-1194
FU Chinese University of Hong Kong (CUHK) Impact Research Postdoctoral
   Scheme
FX A.Y. was supported by the Chinese University of Hong Kong (CUHK) Impact
   Research Postdoctoral Scheme.
CR Ala M, 2021, ACS PHARMACOL TRANSL, V4, P1747, DOI 10.1021/acsptsci.1c00167
   Amer Diabet Assoc, 2021, DIABETES CARE, V44, pS111, DOI 10.2337/dc21-S009
   An HJ, 2016, J DIABETES COMPLICAT, V30, P1017, DOI 10.1016/j.jdiacomp.2016.04.018
   Aroda VR, 2017, DIABETOLOGIA, V60, P1601, DOI 10.1007/s00125-017-4361-9
   Bai MZ, 2018, ONCOGENE, V37, P5666, DOI 10.1038/s41388-018-0360-7
   Bailey CJ, 2008, DIABETOLOGIA, V51, P1552, DOI 10.1007/s00125-008-1053-5
   Bailey CJ, 2017, DIABETOLOGIA, V60, P1566, DOI 10.1007/s00125-017-4318-z
   Ben Sahra I, 2011, CANCER RES, V71, P4366, DOI 10.1158/0008-5472.CAN-10-1769
   Bergmark BA, 2019, CIRCULATION, V140, P1004, DOI 10.1161/CIRCULATIONAHA.119.040144
   Bodmer M, 2010, DIABETES CARE, V33, P1304, DOI 10.2337/dc09-1791
   Bramante CT, 2021, LANCET HEALTH LONGEV, V2, pE34, DOI 10.1016/S2666-7568(20)30033-7
   Breunig IM, 2014, J MANAG CARE SPEC PH, V20, P895, DOI 10.18553/jmcp.2014.20.9.895
   Bugianesi E, 2005, AM J GASTROENTEROL, V100, P1082, DOI 10.1111/j.1572-0241.2005.41583.x
   Buse JB, 2020, DIABETES CARE, V43, P487, DOI 10.2337/dci19-0066
   Cabreiro F, 2013, CELL, V153, P228, DOI 10.1016/j.cell.2013.02.035
   Cabrera CS, 2020, KIDNEY INT REP, V5, P1651, DOI 10.1016/j.ekir.2020.07.029
   Cameron AR, 2016, CIRC RES, V119, P652, DOI 10.1161/CIRCRESAHA.116.308445
   Campbell JM, 2018, J ALZHEIMERS DIS, V65, P1225, DOI 10.3233/JAD-180263
   Campbell JM, 2017, AGEING RES REV, V40, P31, DOI 10.1016/j.arr.2017.08.003
   Cetin M, 2016, DRUG DELIV, V23, P2796, DOI 10.3109/10717544.2015.1089957
   Chang MY, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-07300-x
   Charytan DM, 2019, DIABETES OBES METAB, V21, P1199, DOI 10.1111/dom.13642
   Chaudhari K, 2020, GEROSCIENCE, V42, P97, DOI 10.1007/s11357-019-00146-3
   Chen XY, 2015, AM J PHYSIOL-LUNG C, V309, pL262, DOI 10.1152/ajplung.00389.2014
   Chen Y, 2020, J PHARM INVEST, V50, P219, DOI 10.1007/s40005-020-00480-1
   Chen YC, 2020, DIABETES CARE, V43, P1399, DOI 10.2337/dc20-0660
   Cheng X, 2020, CELL METAB, V32, P537, DOI 10.1016/j.cmet.2020.08.013
   Cheng YY, 2014, J STROKE CEREBROVASC, V23, pE99, DOI 10.1016/j.jstrokecerebrovasdis.2013.09.001
   Currie CJ, 2009, DIABETOLOGIA, V52, P1766, DOI 10.1007/s00125-009-1440-6
   Dalan R, 2020, DIABETES RES CLIN PR, V164, DOI 10.1016/j.diabres.2020.108230
   Davis BJ, 2006, DIABETES, V55, P496, DOI 10.2337/diabetes.55.02.06.db05-1064
   de Jager CPC, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0046561
   de Jager J, 2014, J INTERN MED, V275, P59, DOI 10.1111/joim.12128
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   DeCensi A, 2010, CANCER PREV RES, V3, P1451, DOI 10.1158/1940-6207.CAPR-10-0157
   Ekstrom N, 2012, BMJ OPEN, V2, DOI 10.1136/bmjopen-2012-001076
   Evans JMM, 2006, DIABETOLOGIA, V49, P930, DOI 10.1007/s00125-006-0176-9
   Farkhondeh T, 2021, CURR ONCOL, V28, P1412, DOI 10.3390/curroncol28020134
   Foretz M, 2010, J CLIN INVEST, V120, P2355, DOI 10.1172/JCI40671
   Fung CSC, 2015, CARDIOVASC DIABETOL, V14, DOI 10.1186/s12933-015-0304-2
   Gansevoort RT, 2013, LANCET, V382, P339, DOI 10.1016/S0140-6736(13)60595-4
   Gerich JE, 2000, DIABETES OBES METAB, V2, P345, DOI 10.1046/j.1463-1326.2000.00085.x
   Ghadernezhad N, 2016, PHARM BIOL, V54, P2211, DOI 10.3109/13880209.2016.1150306
   Giaccari A, 2021, DIABETES CARE, V44, P647, DOI 10.2337/dc20-1964
   Goodwin PJ, 2021, NPJ BREAST CANCER, V7, DOI 10.1038/s41523-021-00275-z
   Gormsen LC, 2016, J NUCL MED, V57, P1920, DOI 10.2967/jnumed.116.177774
   Grant PJ, 2003, DIABETES METAB, V29, pS44
   GRANT PJ, 1991, DIABETIC MED, V8, P361, DOI 10.1111/j.1464-5491.1991.tb01610.x
   Griffin SJ, 2017, DIABETOLOGIA, V60, P1620, DOI 10.1007/s00125-017-4337-9
   Guo M, 2014, CLIN EXP PHARMACOL P, V41, P650, DOI 10.1111/1440-1681.12265
   Gurung M, 2020, EBIOMEDICINE, V51, DOI 10.1016/j.ebiom.2019.11.051
   Han YC, 2019, CARDIOVASC DIABETOL, V18, DOI 10.1186/s12933-019-0900-7
   Hardie DG, 2014, ANNU REV NUTR, V34, P31, DOI 10.1146/annurev-nutr-071812-161148
   Harris ST, 2021, DIABETES CARE, V44, P2293, DOI 10.2337/dc21-0529
   Haukeland JW, 2009, SCAND J GASTROENTERO, V44, P853, DOI 10.1080/00365520902845268
   He H, 2015, CANCER J, V21, P70, DOI 10.1097/PPO.0000000000000103
   Heckman-Stoddard BM, 2017, DIABETOLOGIA, V60, P1639, DOI 10.1007/s00125-017-4372-6
   Higurashi T, 2016, LANCET ONCOL, V17, P475, DOI 10.1016/S1470-2045(15)00565-3
   Hohnholt MC, 2017, J NEUROSCI RES, V95, P2307, DOI 10.1002/jnr.24050
   Holman RR, 2008, NEW ENGL J MED, V359, P1577, DOI 10.1056/NEJMoa0806470
   Home PD, 2010, DIABETOLOGIA, V53, P1838, DOI 10.1007/s00125-010-1804-y
   Hsu SK, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22179453
   Hung SC, 2015, LANCET DIABETES ENDO, V3, P605, DOI 10.1016/S2213-8587(15)00123-0
   Jaune E, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00472
   Jeon BS, 2016, BIOTECHNOL BIOFUELS, V9, DOI 10.1186/s13068-016-0549-3
   Jin Q, 2014, BRAIN BEHAV IMMUN, V40, P131, DOI 10.1016/j.bbi.2014.03.003
   Johnson JA, 2002, DIABETES CARE, V25, P2244, DOI 10.2337/diacare.25.12.2244
   Kim DI, 2015, ARCH BIOCHEM BIOPHYS, V584, P90, DOI 10.1016/j.abb.2015.08.009
   Kim HS, 2020, INT J MED SCI, V17, P2551, DOI 10.7150/ijms.50338
   Kim J, 2012, EXP DIABETES RES, DOI 10.1155/2012/210821
   Kita Y, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0043056
   Koenig AM, 2017, ALZ DIS ASSOC DIS, V31, P107, DOI 10.1097/WAD.0000000000000202
   Krakoff J, 2010, OBESITY, V18, P1762, DOI 10.1038/oby.2010.21
   Kristofi R, 2021, J ENDOCRINOL, V251, pR11, DOI 10.1530/JOE-21-0194
   Kwon S, 2020, DIABETES CARE, V43, P948, DOI 10.2337/dc19-0936
   LaMoia TE, 2021, ENDOCR REV, V42, P77, DOI 10.1210/endrev/bnaa023
   Lavine JE, 2011, JAMA-J AM MED ASSOC, V305, P1659, DOI 10.1001/jama.2011.520
   Lee MS, 2011, BMC CANCER, V11, DOI 10.1186/1471-2407-11-20
   Li M, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.01039
   Li X, 2021, EUR J CLIN INVEST, V51, DOI 10.1111/eci.13536
   Li Y, 2013, BIOMED REP, V1, P57, DOI 10.3892/br.2012.18
   Libby G, 2009, DIABETES CARE, V32, P1620, DOI 10.2337/dc08-2175
   Lin HZ, 2000, NAT MED, V6, P998, DOI 10.1038/79697
   Lipska KJ, 2017, DIABETES CARE, V40, P468, DOI 10.2337/dc16-0985
   Liu F, 2014, INT J MOL MED, V33, P51, DOI 10.3892/ijmm.2013.1560
   Loomba R, 2009, ALIMENT PHARM THER, V29, P172, DOI 10.1111/j.1365-2036.2008.03869.x
   Luchsinger JA, 2017, DIABETES CARE, V40, P958, DOI 10.2337/dc16-2376
   Lv ZQ, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.00191
   Ma RX, 2020, ACTA PHARMACOL SIN, V41, P1403, DOI 10.1038/s41401-020-00508-0
   Madiraju AK, 2014, NATURE, V510, P542, DOI 10.1038/nature13270
   Mallik R, 2018, DIABETES RES CLIN PR, V143, P409, DOI 10.1016/j.diabres.2018.05.023
   Mao DD, 2022, HEPATOL COMMUN, V6, P1350, DOI 10.1002/hep4.1891
   Mao DD, 2022, LANCET REG HEALTH-W, V18, DOI 10.1016/j.lanwpc.2021.100315
   Marchesini G, 2001, LANCET, V358, P893, DOI 10.1016/S0140-6736(01)06042-1
   Marfella R, 1996, DIABETES CARE, V19, P934, DOI 10.2337/diacare.19.9.934
   Marshall SM, 2017, DIABETOLOGIA, V60, P1561, DOI 10.1007/s00125-017-4343-y
   Mather KJ, 2001, J AM COLL CARDIOL, V37, P1344, DOI 10.1016/S0735-1097(01)01129-9
   McNeilly AD, 2012, DIABETOLOGIA, V55, P3061, DOI 10.1007/s00125-012-2686-y
   Menegazzo L, 2018, ACTA DIABETOL, V55, P593, DOI 10.1007/s00592-018-1129-8
   Mogensen UM, 2015, DIABETOLOGIA, V58, P50, DOI 10.1007/s00125-014-3372-z
   Monami M, 2021, NUTR METAB CARDIOVAS, V31, P699, DOI 10.1016/j.numecd.2020.11.031
   Moore E, 2012, INT PSYCHOGERIATR, V24, P541, DOI 10.1017/S1041610211002511
   Moore EM, 2013, DIABETES CARE, V36, P2981, DOI 10.2337/dc13-0229
   Mor A, 2016, BMJ OPEN, V6, DOI 10.1136/bmjopen-2016-011523
   Morgan CL, 2014, DIABETES OBES METAB, V16, P957, DOI 10.1111/dom.12302
   Mortensen E, 2018, EUR RESPIR J, V52, DOI 10.1183/13993003.congress-2018.PA2639
   Mostafa DK, 2016, PSYCHOPHARMACOLOGY, V233, P2513, DOI 10.1007/s00213-016-4301-2
   Nafisa A, 2018, PHARMACOL THERAPEUT, V192, P150, DOI 10.1016/j.pharmthera.2018.07.007
   Navaneethan SD, 2021, ANN INTERN MED, V174, P385, DOI 10.7326/M20-5938
   Neven E, 2018, KIDNEY INT, V94, P102, DOI 10.1016/j.kint.2018.01.027
   Ng TP, 2014, J ALZHEIMERS DIS, V41, P61, DOI 10.3233/JAD-131901
   Oliveira WH, 2016, BRAIN RES, V1644, P149, DOI 10.1016/j.brainres.2016.05.013
   Omer Z, 2010, EUR J GASTROEN HEPAT, V22, P18, DOI 10.1097/MEG.0b013e32832e2baf
   Ou ZR, 2018, BRAIN BEHAV IMMUN, V69, P351, DOI 10.1016/j.bbi.2017.12.009
   Pantalone KM, 2012, DIABETES OBES METAB, V14, P803, DOI 10.1111/j.1463-1326.2012.01604.x
   Pernicova I, 2020, LANCET DIABETES ENDO, V8, P278, DOI 10.1016/S2213-8587(20)30021-8
   Pernicova I, 2014, NAT REV ENDOCRINOL, V10, P143, DOI 10.1038/nrendo.2013.256
   Petrie JR, 2020, DIABETES OBES METAB, V22, P904, DOI 10.1111/dom.13984
   Phung OJ, 2010, JAMA-J AM MED ASSOC, V303, P1410, DOI 10.1001/jama.2010.405
   Pimentel I, 2021, JNCI-J NATL CANCER I, V113, P192, DOI 10.1093/jnci/djaa082
   Pimentel I, 2019, BREAST, V48, P17, DOI 10.1016/j.breast.2019.08.003
   Poly TN, 2021, J CLIN MED, V10, DOI 10.3390/jcm10163507
   Porter KM, 2019, J CLIN ENDOCR METAB, V104, P4837, DOI 10.1210/jc.2018-01791
   Raee MR, 2017, ARCH IRAN MED, V20, P141, DOI 0172003/AIM.005
   Rattan R, 2011, J CELL MOL MED, V15, P166, DOI 10.1111/j.1582-4934.2009.00954.x
   Rattan R, 2012, J ONCOL, V2012, DOI 10.1155/2012/928127
   Rena G, 2017, DIABETOLOGIA, V60, P1577, DOI 10.1007/s00125-017-4342-z
   Rodriguez-Carlos A, 2020, MICROBES INFECT, V22, P111, DOI 10.1016/j.micinf.2019.10.002
   Roumie CL, 2019, JAMA-J AM MED ASSOC, V322, P1167, DOI 10.1001/jama.2019.13206
   Roumie CL, 2017, J AM HEART ASSOC, V6, DOI 10.1161/JAHA.116.005379
   Roumie CL, 2012, ANN INTERN MED, V157, P601, DOI 10.7326/0003-4819-157-9-201211060-00003
   Salpeter S, 2006, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD002967.pub2
   Samaras K, 2020, DIABETES CARE, V43, P2691, DOI 10.2337/dc20-0892
   Samuel SM, 2021, TRENDS MICROBIOL, V29, P894, DOI 10.1016/j.tim.2021.03.004
   Scharping NE, 2017, CANCER IMMUNOL RES, V5, P9, DOI 10.1158/2326-6066.CIR-16-0103
   Scheller NM, 2014, DIABETES OBES METAB, V16, P231, DOI 10.1111/dom.12197
   Schrijvers BF, 2004, ENDOCR REV, V25, P971, DOI 10.1210/er.2003-0018
   Sharma S, 2020, DIABETES RES CLIN PR, V164, DOI 10.1016/j.diabres.2020.108183
   Sillars B, 2010, DIABETES OBES METAB, V12, P757, DOI 10.1111/j.1463-1326.2010.01230.x
   Singhal A, 2014, SCI TRANSL MED, V6, DOI 10.1126/scitranslmed.3009885
   Song AN, 2021, BIOMED PHARMACOTHER, V138, DOI 10.1016/j.biopha.2021.111454
   Suissa S, 2012, DIABETES CARE, V35, P2665, DOI 10.2337/dc12-0788
   Sun H, 2022, DIABETES RES CLIN PR, V183, DOI 10.1016/j.diabres.2021.109119
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Tahrani AA, 2011, LANCET, V378, P182, DOI 10.1016/S0140-6736(11)60207-9
   Triggle CR, 2017, ACTA PHYSIOL, V219, P138, DOI 10.1111/apha.12644
   Turroni F, 2016, ISME J, V10, P1656, DOI 10.1038/ismej.2015.236
   Uygun A, 2004, ALIMENT PHARM THER, V19, P537, DOI 10.1111/j.1365-2036.2004.01888.x
   Vallianou NG, 2019, HORM-INT J ENDOCRINO, V18, P141, DOI 10.1007/s42000-019-00093-w
   Vancura A, 2018, TRENDS PHARMACOL SCI, V39, P867, DOI 10.1016/j.tips.2018.07.006
   Viberti G, 2002, DIABETES CARE, V25, P1737, DOI 10.2337/diacare.25.10.1737
   Whitlock RH, 2020, MAYO CLIN PROC, V95, P90, DOI 10.1016/j.mayocp.2019.07.017
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Xin G, 2016, SCI REP-UK, V6, DOI 10.1038/srep36222
   Xiong Y, 2020, ADV THER-GERMANY, V3, DOI 10.1002/adtp.202000168
   Yang AM, 2021, DIABETOLOGIA, V64, P1760, DOI 10.1007/s00125-021-05452-0
   Yang AM, 2020, DIABETES CARE, V43, P2967, DOI 10.2337/dc20-0260
   Yang XL, 2015, NAT REV ENDOCRINOL, V11, P372, DOI 10.1038/nrendo.2015.37
   Yang XL, 2011, DIABETES CARE, V34, P375, DOI 10.2337/dc10-1509
   Yu JW, 2016, CARDIOVASC DIABETOL, V15, DOI 10.1186/s12933-016-0408-3
   Yu SJ, 2019, BIOMED RES INT, V2019, DOI 10.1155/2019/5280514
   Yu XY, 2019, BMC INFECT DIS, V19, DOI 10.1186/s12879-019-4548-4
   Zhang K, 2020, DIABETES RES CLIN PR, V160, DOI 10.1016/j.diabres.2020.108001
   Zhao YL, 2020, LIFE SCI, V246, DOI 10.1016/j.lfs.2020.117382
   Zheng Z, 2012, DIABETES, V61, P217, DOI 10.2337/db11-0416
NR 165
TC 6
Z9 6
U1 4
U2 15
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1424-8247
J9 PHARMACEUTICALS-BASE
JI Pharmaceuticals
PD APR
PY 2022
VL 15
IS 4
AR 442
DI 10.3390/ph15040442
PG 26
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 0Q9FJ
UT WOS:000785214700001
PM 35455439
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Shoshan-Barmatz, V
   Anand, U
   Nahon-Crystal, E
   Di Carlo, M
   Shteinfer-Kuzmine, A
AF Shoshan-Barmatz, Varda
   Anand, Uttpal
   Nahon-Crystal, Edna
   Di Carlo, Marta
   Shteinfer-Kuzmine, Anna
TI Adverse Effects of Metformin From Diabetes to COVID-19, Cancer,
   Neurodegenerative Diseases, and Aging: Is VDAC1 a Common Target?
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Review
DE apoptosis; cancer; metabolism; metformin; hexokinase; COVID-19;
   mitochondria; VDAC
ID DEPENDENT ANION CHANNEL; ACTIVATED PROTEIN-KINASE; MITOCHONDRIAL
   PERMEABILITY TRANSITION; ANTIDIABETIC DRUG METFORMIN; CYTOCHROME-C
   RELEASE; APOPTOTIC CELL-DEATH; ALZHEIMERS-DISEASE; AMYLOID-BETA;
   COGNITIVE IMPAIRMENT; INSULIN-RESISTANCE
AB Metformin has been used for treating diabetes mellitus since the late 1950s. In addition to its antihyperglycemic activity, it was shown to be a potential drug candidate for treating a range of other diseases that include various cancers, cardiovascular diseases, diabetic kidney disease, neurodegenerative diseases, renal diseases, obesity, inflammation, COVID-19 in diabetic patients, and aging. In this review, we focus on the important aspects of mitochondrial dysfunction in energy metabolism and cell death with their gatekeeper VDAC1 (voltage-dependent anion channel 1) as a possible metformin target, and summarize metformin's effects in several diseases and gut microbiota. We question how the same drug can act on diseases with opposite characteristics, such as increasing apoptotic cell death in cancer, while inhibiting it in neurodegenerative diseases. Interestingly, metformin's adverse effects in many diseases all show VDAC1 involvement, suggesting that it is a common factor in metformin-affecting diseases. The findings that metformin has an opposite effect on various diseases are consistent with the fact that VDAC1 controls cell life and death, supporting the idea that it is a target for metformin.
C1 [Shoshan-Barmatz, Varda; Anand, Uttpal] Ben Gurion Univ Negev, Dept Life Sci, Beer Sheva, Israel.
   [Shoshan-Barmatz, Varda; Shteinfer-Kuzmine, Anna] Ben Gurion Univ Negev, Natl Inst Biotechnol Negev, Beer Sheva, Israel.
   [Nahon-Crystal, Edna] Achva Acad Coll, Arugot, Israel.
   [Di Carlo, Marta] CNR, Inst Biomed Res & Innovat, Palermo, Italy.
C3 Ben Gurion University; Ben Gurion University; Consiglio Nazionale delle
   Ricerche (CNR); Istituto Ricerca l'Innovazione Biomedica (IRIB-CNR)
RP Shoshan-Barmatz, V (通讯作者)，Ben Gurion Univ Negev, Dept Life Sci, Beer Sheva, Israel.; Shoshan-Barmatz, V (通讯作者)，Ben Gurion Univ Negev, Natl Inst Biotechnol Negev, Beer Sheva, Israel.
EM vardasb@bgu.ac.il
OI Anand, Uttpal/0000-0001-5924-7866
CR Abu-Hamad S, 2006, P NATL ACAD SCI USA, V103, P5787, DOI 10.1073/pnas.0600103103
   Abu-Hamad S, 2008, J BIOL CHEM, V283, P13482, DOI 10.1074/jbc.M708216200
   Abu-Hamad S, 2009, J CELL SCI, V122, P1906, DOI 10.1242/jcs.040188
   Ahmed M, 2010, ISLETS, V2, P283, DOI 10.4161/isl.2.5.12639
   Ahtiluoto S, 2010, NEUROLOGY, V75, P1195, DOI 10.1212/WNL.0b013e3181f4d7f8
   Ajaz S, 2021, AM J PHYSIOL-CELL PH, V320, pC57, DOI 10.1152/ajpcell.00426.2020
   Al-Zaidan L, 2017, FRONT PUBLIC HEALTH, V5, DOI 10.3389/fpubh.2017.00277
   Alfaras I, 2017, NPJ AGING MECH DIS, V3, DOI 10.1038/s41514-017-0018-7
   Amsalem Z, 2020, CANCERS, V12, DOI 10.3390/cancers12041031
   Andrzejewski S, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00372
   Anisimov VN, 2015, ONCOTARGET, V6, P39398, DOI 10.18632/oncotarget.6347
   [Anonymous], 2014, DIABETES CARE, V37, pS81, DOI [DOI 10.2337/dc14-S081, 10.2337/dc14-S081]
   Apicella M, 2020, LANCET DIABETES ENDO, V8, P782, DOI 10.1016/S2213-8587(20)30238-2
   Arbel N, 2012, J BIOL CHEM, V287, P23152, DOI 10.1074/jbc.M112.345918
   Arbel N, 2010, J BIOL CHEM, V285, P6053, DOI 10.1074/jbc.M109.082990
   Arif T, 2019, CELLS-BASEL, V8, DOI 10.3390/cells8111330
   Arif T, 2019, MOL THER-NUCL ACIDS, V17, P24, DOI 10.1016/j.omtn.2019.05.003
   Arif T, 2018, CANCERS, V10, DOI 10.3390/cancers10120499
   Arif T, 2017, NEURO-ONCOLOGY, V19, P951, DOI 10.1093/neuonc/now297
   Arif T, 2014, MOL THER-NUCL ACIDS, V3, DOI 10.1038/mtna.2014.9
   ARRIAGADA PV, 1992, NEUROLOGY, V42, P631, DOI 10.1212/WNL.42.3.631
   Arvanitakis Z, 2004, ARCH NEUROL-CHICAGO, V61, P661, DOI 10.1001/archneur.61.5.661
   Arzoine L, 2009, J BIOL CHEM, V284, P3946, DOI 10.1074/jbc.M803614200
   Azoulay-Zohar H, 2004, BIOCHEM J, V377, P347, DOI 10.1042/BJ20031465
   Bailey CJ, 2017, DIABETOLOGIA, V60, P1566, DOI 10.1007/s00125-017-4318-z
   Bannister CA, 2014, DIABETES OBES METAB, V16, P1165, DOI 10.1111/dom.12354
   Bauman WA, 2000, DIABETES CARE, V23, P1227, DOI 10.2337/diacare.23.9.1227
   Baur JA, 2014, CELL METAB, V20, P197, DOI 10.1016/j.cmet.2014.07.013
   Bayliss JA, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0159381
   Bayrhuber M, 2008, P NATL ACAD SCI USA, V105, P15370, DOI 10.1073/pnas.0808115105
   Ben Sahra I, 2010, MOL CANCER THER, V9, P1092, DOI 10.1158/1535-7163.MCT-09-1186
   Ben Sahra I, 2010, CANCER RES, V70, P2465, DOI 10.1158/0008-5472.CAN-09-2782
   Ben-Hail D, 2016, J BIOL CHEM, V291, P24986, DOI 10.1074/jbc.M116.744284
   Ben-Hail D, 2016, BBA-MOL CELL RES, V1863, P1612, DOI 10.1016/j.bbamcr.2016.04.002
   Betaneli V, 2012, BIOPHYS J, V102, P523, DOI 10.1016/j.bpj.2011.12.049
   Biondani G, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00446
   Borst P, 2002, ANNU REV BIOCHEM, V71, P537, DOI 10.1146/annurev.biochem.71.102301.093055
   Bost F, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00851
   Boulbrima A, 2016, BIOCHEM SOC T, V44, P1531, DOI 10.1042/BST20160114
   Bramante CT, 2021, LANCET HEALTH LONGEV, V2, pE34, DOI 10.1016/S2666-7568(20)30033-7
   Brandt A, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-43228-0
   Bridges HR, 2014, BIOCHEM J, V462, P475, DOI 10.1042/BJ20140620
   BRION JP, 1985, J SUBMICR CYTOL PATH, V17, P89
   Bryrup T, 2019, DIABETOLOGIA, V62, P1024, DOI 10.1007/s00125-019-4848-7
   Bryson JM, 2002, J BIOL CHEM, V277, P11392, DOI 10.1074/jbc.M110927200
   Bueno KO, 2015, NEUROSCIENCE, V294, P29, DOI 10.1016/j.neuroscience.2015.03.001
   Cameron AR, 2016, CIRC RES, V119, P652, DOI 10.1161/CIRCRESAHA.116.308445
   Campbell JM, 2018, J ALZHEIMERS DIS, V65, P1225, DOI 10.3233/JAD-180263
   Castagna A, 2004, PROTEOMICS, V4, P3246, DOI 10.1002/pmic.200400835
   Caterino M, 2017, MOL BIOSYST, V13, P2466, DOI 10.1039/c7mb00434f
   Chen K, 2017, MOL CANCER, V16, DOI 10.1186/s12943-017-0701-0
   Chen LJ, 2020, EMERG MICROBES INFEC, V9, P313, DOI 10.1080/22221751.2020.1725399
   Chen XY, 2020, FRONT IMMUNOL, V11, DOI 10.3389/fimmu.2020.02056
   Chen YM, 2009, P NATL ACAD SCI USA, V106, P3907, DOI 10.1073/pnas.0807991106
   Cheng G, 2012, INTERN MED J, V42, P484, DOI 10.1111/j.1445-5994.2012.02758.x
   Cheng X, 2020, CELL METAB, V32, P537, DOI 10.1016/j.cmet.2020.08.013
   Chin HS, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-018-07309-4
   Chistiakov DA, 2014, BIOMED RES INT, V2014, DOI 10.1155/2014/238463
   Cignarelli A, 2018, DIABETES RES CLIN PR, V143, P378, DOI 10.1016/j.diabres.2018.04.002
   Collins Karen K, 2014, Diabetes Spectr, V27, P276, DOI 10.2337/diaspect.27.4.276
   Colombini M, 2016, BBA-MOL CELL RES, V1863, P2498, DOI 10.1016/j.bbamcr.2016.01.019
   Colurso GJ, 2003, LIFE SCI, V73, P1795, DOI 10.1016/S0024-3205(03)00512-5
   Cossor FI, 2012, J CLIN ONCOL, V30
   Coughlan KA, 2014, DIABET METAB SYND OB, V7, P241, DOI 10.2147/DMSO.S43731
   Coyle C, 2016, ANN ONCOL, V27, P2184, DOI 10.1093/annonc/mdw410
   Craft S, 2007, CURR ALZHEIMER RES, V4, P147, DOI 10.2174/156720507780362137
   Cuadrado-Tejedor M, 2011, J ALZHEIMERS DIS, V23, P195, DOI 10.3233/JAD-2010-100966
   Curry DW, 2018, J PARKINSON DIS, V8, P161, DOI 10.3233/JPD-171296
   Da Silva D, 2010, ARCH BIOCHEM BIOPHYS, V496, P53, DOI 10.1016/j.abb.2010.01.013
   Dardano A, 2021, LANCET HEALTH LONGEV, V2, pE6, DOI 10.1016/S2666-7568(20)30047-7
   Davies G, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0187191
   De Haes W, 2014, P NATL ACAD SCI USA, V111, pE2501, DOI 10.1073/pnas.1321776111
   de Kreutzenberg SV, 2015, NUTR METAB CARDIOVAS, V25, P686, DOI 10.1016/j.numecd.2015.03.007
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Figueiredo RAD, 2016, ORAL ONCOL, V61, P47, DOI 10.1016/j.oraloncology.2016.08.006
   De Pinto V, 2021, BIOMOLECULES, V11, DOI 10.3390/biom11010107
   De Pinto V, 2010, BBA-BIOENERGETICS, V1797, P1268, DOI 10.1016/j.bbabio.2010.01.031
   Del Barco S, 2011, ONCOTARGET, V2, P896, DOI 10.18632/oncotarget.387
   Demare S, 2021, EXPERT REV NEUROTHER, V21, P45, DOI 10.1080/14737175.2021.1847645
   Detaille D, 2005, DIABETES, V54, P2179, DOI 10.2337/diabetes.54.7.2179
   Djiogue S, 2013, ENDOCR-RELAT CANCER, V20, pR1, DOI 10.1530/ERC-12-0324
   Donath MY, 2011, NAT REV IMMUNOL, V11, P98, DOI 10.1038/nri2925
   Dorszewska J, 2016, CURR ALZHEIMER RES, V13, P952, DOI 10.2174/1567205013666160314150501
   Dowling RJO, 2011, BMC MED, V9, DOI 10.1186/1741-7015-9-33
   Drahota Z, 2014, PHYSIOL RES, V63, P1, DOI 10.33549/physiolres.932600
   Duan CC, 2021, PHYTOTHER RES, V35, P1378, DOI 10.1002/ptr.6898
   El-Awady Raafat, 2016, Front Pharmacol, V7, P535, DOI 10.3389/fphar.2016.00535
   El-Mir MY, 2008, J MOL NEUROSCI, V34, P77, DOI 10.1007/s12031-007-9002-1
   El-Mir MY, 2000, J BIOL CHEM, V275, P223, DOI 10.1074/jbc.275.1.223
   English E, 2018, CRIT REV CL LAB SCI, V55, P408, DOI 10.1080/10408363.2018.1480591
   Evans JMM, 2010, AM J CARDIOL, V106, P1006, DOI 10.1016/j.amjcard.2010.05.031
   Fang JQ, 2018, AGING CELL, V17, DOI 10.1111/acel.12765
   Fatt M, 2015, STEM CELL REP, V5, P988, DOI 10.1016/j.stemcr.2015.10.014
   Feigin VL, 2017, LANCET NEUROL, V16, P877, DOI 10.1016/S1474-4422(17)30299-5
   Fernandez-Echevarria C, 2014, NEUROSCIENCE, V278, P354, DOI 10.1016/j.neuroscience.2014.07.079
   Ferrer I, 2009, J BIOENERG BIOMEMBR, V41, P425, DOI 10.1007/s10863-009-9243-5
   Fontaine Eric, 2014, Biochem J, V463, pe3, DOI 10.1042/BJ20141020
   Foretz M, 2014, CELL METAB, V20, P953, DOI 10.1016/j.cmet.2014.09.018
   Formoso G, 2008, DIABETES-METAB RES, V24, P231, DOI 10.1002/dmrr.794
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Freitas ME, 2017, SEMIN NEUROL, V37, P147, DOI 10.1055/s-0037-1602423
   Friedlander RM, 2003, NEW ENGL J MED, V348, P1365, DOI 10.1056/NEJMra022366
   Fulda S, 2009, INT J CANCER, V124, P511, DOI 10.1002/ijc.24064
   Gallagher EJ, 2010, TRENDS ENDOCRIN MET, V21, P610, DOI 10.1016/j.tem.2010.06.007
   Galtier F, 2010, DIABETES METAB, V36, P628, DOI 10.1016/j.diabet.2010.11.014
   Ganguly P, 2015, NUTR J, V14, DOI 10.1186/1475-2891-14-6
   Garg G, 2017, REJUV RES, V20, P16, DOI 10.1089/rej.2016.1826
   Garrido C, 2006, CELL DEATH DIFFER, V13, P1423, DOI 10.1038/sj.cdd.4401950
   Gervais FG, 1999, CELL, V97, P395, DOI 10.1016/S0092-8674(00)80748-5
   Geula S, 2012, BIOCHEM J, V444, P475, DOI 10.1042/BJ20112079
   Geula S, 2012, J BIOL CHEM, V287, P2179, DOI 10.1074/jbc.M111.268920
   Ghatak SB, 2011, EUR J PHARMACOL, V659, P213, DOI 10.1016/j.ejphar.2011.03.029
   Ghosh T, 2007, PLOS ONE, V2, DOI 10.1371/journal.pone.0001170
   Godbole A, 2003, BBA-MOL CELL RES, V1642, P87, DOI 10.1016/S0167-4889(03)00102-2
   Gong L, 2012, PHARMACOGENET GENOM, V22, P820, DOI 10.1097/FPC.0b013e3283559b22
   Gormsen LC, 2016, J NUCL MED, V57, P1920, DOI 10.2967/jnumed.116.177774
   Griffin SJ, 2017, DIABETOLOGIA, V60, P1620, DOI 10.1007/s00125-017-4337-9
   Groebe K, 2010, EXP GERONTOL, V45, P632, DOI 10.1016/j.exger.2010.02.006
   Guigas B, 2004, BIOCHEM J, V382, P877, DOI 10.1042/BJ20040885
   Guo M, 2014, CLIN EXP PHARMACOL P, V41, P650, DOI 10.1111/1440-1681.12265
   Hanahan D, 2000, CELL, V100, P57, DOI 10.1016/S0092-8674(00)81683-9
   Hanahan D, 2011, CELL, V144, P646, DOI 10.1016/j.cell.2011.02.013
   He L, 2015, CELL METAB, V21, P159, DOI 10.1016/j.cmet.2015.01.003
   Higurashi T, 2016, LANCET ONCOL, V17, P475, DOI 10.1016/S1470-2045(15)00565-3
   Hiller S, 2008, SCIENCE, V321, P1206, DOI 10.1126/science.1161302
   Hitchings AW, 2016, THORAX, V71, P587, DOI 10.1136/thoraxjnl-2015-208035
   Hori H, 2002, DIABETES, V51, P2387, DOI 10.2337/diabetes.51.8.2387
   Hotta N, 2019, J DIABETES INVEST, V10, P906, DOI 10.1111/jdi.13090
   Hou YJ, 2019, NAT REV NEUROL, V15, P565, DOI 10.1038/s41582-019-0244-7
   Howell JJ, 2017, CELL METAB, V25, P463, DOI 10.1016/j.cmet.2016.12.009
   Hsu CC, 2011, J ALZHEIMERS DIS, V24, P485, DOI 10.3233/JAD-2011-101524
   Huang L, 2015, J BIOL CHEM, V290, P23563, DOI 10.1074/jbc.M115.648774
   Huang Y, 2020, ACTA PHARMACOL SIN, V41, P1141, DOI 10.1038/s41401-020-0485-4
   IDF, 2019, IDF DIABETES ATLAS, V9th
   Imfeld P, 2012, J AM GERIATR SOC, V60, P916, DOI 10.1111/j.1532-5415.2012.03916.x
   Jackson JG, 2015, J NEUROSCI RES, V93, P999, DOI 10.1002/jnr.23533
   Jalving M, 2010, EUR J CANCER, V46, P2369, DOI 10.1016/j.ejca.2010.06.012
   Jiang L, 2018, FREE RADICAL BIO MED, V117, P58, DOI 10.1016/j.freeradbiomed.2017.12.015
   Jiang WJ, 2007, J NEUROSCI RES, V85, P3160, DOI 10.1002/jnr.21384
   Johnson GVW, 2004, J CELL SCI, V117, P5721, DOI 10.1242/jcs.01558
   Johnstone RW, 2002, CELL, V108, P153, DOI 10.1016/S0092-8674(02)00625-6
   Joshi AA, 2016, PHARM RES-DORDR, V33, P2847, DOI 10.1007/s11095-016-2028-8
   Jozwiak P., 2020, TUMOUR BIOL, V42
   Kalender A, 2010, CELL METAB, V11, P390, DOI 10.1016/j.cmet.2010.03.014
   Kang CF, 2018, ENDOCRINOLOGY, V159, P3801, DOI 10.1210/en.2018-00574
   Kanwar P, 2020, CRIT REV BIOTECHNOL, V40, P715, DOI 10.1080/07388551.2020.1756214
   Karnewar S, 2018, BBA-MOL BASIS DIS, V1864, P1115, DOI 10.1016/j.bbadis.2018.01.018
   Kasznicki J, 2014, ANN TRANSL MED, V2, DOI 10.3978/j.issn.2305-5839.2014.06.01
   Katila N, 2017, NEUROPHARMACOLOGY, V125, P396, DOI 10.1016/j.neuropharm.2017.08.015
   Keinan N, 2013, BBA-MOL CELL RES, V1833, P1745, DOI 10.1016/j.bbamcr.2013.03.017
   Keinan N, 2010, MOL CELL BIOL, V30, P5698, DOI 10.1128/MCB.00165-10
   Kickstein E, 2010, P NATL ACAD SCI USA, V107, P21830, DOI 10.1073/pnas.0912793107
   Kielar C, 2009, HUM MOL GENET, V18, P4066, DOI 10.1093/hmg/ddp355
   Kim J, 2019, SCIENCE, V366, P1531, DOI 10.1126/science.aav4011
   Kim J, 2019, MEDICINE, V98, DOI 10.1097/MD.0000000000017918
   Klapper-Goldstein H, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-79056-w
   Koren I, 2010, CANCER BIOL THER, V9, P1046, DOI 10.4161/cbt.9.12.11879
   Kourelis TV, 2012, MED ONCOL, V29, P1314, DOI 10.1007/s12032-011-9846-7
   Kroemer G, 2007, PHYSIOL REV, V87, P99, DOI 10.1152/physrev.00013.2006
   Lablanche S, 2011, CELL DEATH DIS, V2, DOI 10.1038/cddis.2011.15
   Labuzek K, 2010, PHARMACOL REP, V62, P956
   Lai JC, 2006, P NATL ACAD SCI USA, V103, P7494, DOI 10.1073/pnas.0602217103
   Lee JO, 2019, BREAST CANCER RES, V21, DOI 10.1186/s13058-019-1204-2
   Lee K, 2011, J BIOL CHEM, V286, P25655, DOI 10.1074/jbc.M111.228692
   Lee YS, 2016, ONCOL REP, V35, P3735, DOI 10.3892/or.2016.4740
   Letko M, 2020, NAT MICROBIOL, V5, P562, DOI [10.1038/s41564-020-0688-y, 10.1101/2020.01.22.915660]
   Lezi E, 2012, ADV EXP MED BIOL, V942, P269, DOI 10.1007/978-94-007-2869-1_12
   Li MW, 2000, SCIENCE, V288, P335, DOI 10.1126/science.288.5464.335
   Liao ZP, 2015, MOL NUTR FOOD RES, V59, P454, DOI 10.1002/mnfr.201400730
   Lim DS, 2001, J AM COLL CARDIOL, V38, P1175, DOI 10.1016/S0735-1097(01)01509-1
   Lim S, 2021, NAT REV ENDOCRINOL, V17, P11, DOI 10.1038/s41574-020-00435-4
   Liu J, 2019, BIOSCIENCE REP, V39, DOI 10.1042/BSR20181994
   Liu QL, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100379
   Loubiere C, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-05052-2
   Lu AJ, 2007, FISH SHELLFISH IMMUN, V23, P601, DOI 10.1016/j.fsi.2007.01.007
   Lu M, 2016, INT J NEUROPSYCHOPH, V19, DOI 10.1093/ijnp/pyw047
   Luengo A, 2014, BMC BIOL, V12, DOI 10.1186/s12915-014-0082-4
   Luo P, 2020, AM J TROP MED HYG, V103, P69, DOI 10.4269/ajtmh.20-0375
   Lv ZQ, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.00191
   Madiraju AK, 2014, NATURE, V510, P542, DOI 10.1038/nature13270
   Magri A, 2018, FRONT CHEM, V6, DOI 10.3389/fchem.2018.00108
   Majewski N, 2004, MOL CELL BIOL, V24, P730, DOI 10.1128/MCB.24.2.730-740.2004
   Malia TJ, 2007, BIOCHEMISTRY-US, V46, P514, DOI 10.1021/bi061577h
   Malki A, 2011, ONCOL RES, V19, P275, DOI 10.3727/096504011X13021877989838
   Manczak M, 2012, HUM MOL GENET, V21, P5131, DOI 10.1093/hmg/dds360
   Marini C, 2013, CELL CYCLE, V12, P3490, DOI 10.4161/cc.26461
   Martin-Montalvo A, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms3192
   Maruthur NM, 2016, ANN INTERN MED, V164, P740, DOI 10.7326/M15-2650
   Mathupala SP, 2006, ONCOGENE, V25, P4777, DOI 10.1038/sj.onc.1209603
   Matsuoka Y, 2021, CLIN EXP RHEUMATOL, V39, P763, DOI 10.55563/clinexprheumatol/zn2u9h
   Mattson MP, 2008, NEURON, V60, P748, DOI 10.1016/j.neuron.2008.10.010
   Maurya SR, 2016, FEBS J, V283, P1831, DOI 10.1111/febs.13637
   Mazure NM, 2017, BBA-BIOENERGETICS, V1858, P665, DOI 10.1016/j.bbabio.2017.03.002
   Mazza A, 2012, EXP DIABETES RES, DOI 10.1155/2012/716404
   Mc Menamin UC, 2016, INT J CANCER, V138, P369, DOI 10.1002/ijc.29720
   McBride HM, 2006, CURR BIOL, V16, pR551, DOI 10.1016/j.cub.2006.06.054
   McCreight LJ, 2016, DIABETOLOGIA, V59, P426, DOI 10.1007/s00125-015-3844-9
   Messina A, 2012, BBA-BIOMEMBRANES, V1818, P1466, DOI 10.1016/j.bbamem.2011.10.005
   Miller RA, 2013, NATURE, V494, P256, DOI 10.1038/nature11808
   Mogavero A, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-16149-z
   Mohan M, 2019, EUR HEART J, V40, P3409, DOI 10.1093/eurheartj/ehz203
   Monlun M, 2017, J MOL BIOL, V429, P1, DOI 10.1016/j.jmb.2016.10.028
   Moore E, 2012, INT PSYCHOGERIATR, V24, P541, DOI 10.1017/S1041610211002511
   Moore EM, 2013, DIABETES CARE, V36, P2981, DOI 10.2337/dc13-0229
   Murphy MP, 2018, NAT REV DRUG DISCOV, V17, P865, DOI 10.1038/nrd.2018.174
   Musi N, 2002, DIABETES, V51, P2074, DOI 10.2337/diabetes.51.7.2074
   Naghdi S, 2016, BBA-MOL CELL RES, V1863, P2503, DOI 10.1016/j.bbamcr.2016.04.020
   Nahon E, 2005, FEBS LETT, V579, P5105, DOI 10.1016/j.febslet.2005.08.020
   Nakajima H, 2020, LIFE-BASEL, V10, DOI 10.3390/life10090195
   Nandini HS, 2019, LIFE SCI, V233, DOI 10.1016/j.lfs.2019.116686
   Nasri H, 2014, J RES MED SCI, V19, P658
   NCD Risk Factor Collaboration (NCD-RisC), 2016, LANCET, V387, P1513, DOI [DOI 10.1016/S0140-6736(16)00618-8, 10.1016/S0140-6736(16)00618-8]
   Neumann Daniel, 2010, PMC Biophys, V3, P4, DOI 10.1186/1757-5036-3-4
   Neurath MF, 2011, CYTOKINE GROWTH F R, V22, P83, DOI 10.1016/j.cytogfr.2011.02.003
   Niafar M, 2015, INTERN EMERG MED, V10, P93, DOI 10.1007/s11739-014-1157-5
   Norwood Daryn K, 2013, Consult Pharm, V28, P579, DOI 10.4140/TCP.n.2013.579
   Novelle MG, 2016, CSH PERSPECT MED, V6, DOI 10.1101/cshperspect.a025932
   Carrillo IO, 2017, HEMATOLOGY, V22, P286, DOI 10.1080/10245332.2016.1265780
   Ott A, 1999, NEUROLOGY, V53, P1937, DOI 10.1212/WNL.53.9.1937
   Ou ZR, 2018, BRAIN BEHAV IMMUN, V69, P351, DOI 10.1016/j.bbi.2017.12.009
   Ouyang JY, 2011, J BIOL CHEM, V286, P1, DOI 10.1074/jbc.M110.121806
   Ouyang J, 2020, AIDS RES THER, V17, DOI 10.1186/s12981-020-00267-2
   Owen MR, 2000, BIOCHEM J, V348, P607, DOI 10.1042/0264-6021:3480607
   Palmer SC, 2016, JAMA-J AM MED ASSOC, V316, P313, DOI 10.1001/jama.2016.9400
   Pastorino JG, 2005, CANCER RES, V65, P10545, DOI 10.1158/0008-5472.CAN-05-1925
   Pastorino JG, 2002, J BIOL CHEM, V277, P7610, DOI 10.1074/jbc.M109950200
   Pastorino JG, 2008, J BIOENERG BIOMEMBR, V40, P171, DOI 10.1007/s10863-008-9148-8
   Patil SP, 2014, NEUROSCIENCE, V277, P747, DOI 10.1016/j.neuroscience.2014.07.046
   Pedersen PL, 2002, BBA-BIOENERGETICS, V1555, P14, DOI 10.1016/S0005-2728(02)00248-7
   Perez-Gracia E, 2008, ACTA NEUROPATHOL, V116, P261, DOI 10.1007/s00401-008-0370-6
   Perlman S, 2020, NEW ENGL J MED, V382, P760, DOI 10.1056/NEJMe2001126
   Pernicova I, 2014, NAT REV ENDOCRINOL, V10, P143, DOI 10.1038/nrendo.2013.256
   Petrozzi L, 2007, BIOSCIENCE REP, V27, P87, DOI 10.1007/s10540-007-9038-z
   Picone P, 2016, AGING-US, V8, P1718, DOI 10.18632/aging.101004
   Pierotti MA, 2013, ONCOGENE, V32, P1475, DOI 10.1038/onc.2012.181
   Pintana H, 2012, LIFE SCI, V91, P409, DOI 10.1016/j.lfs.2012.08.017
   Piskovatska V, 2019, BIOGERONTOLOGY, V20, P33, DOI 10.1007/s10522-018-9773-5
   Pittala S, 2019, MOL THER, V27, P1848, DOI 10.1016/j.ymthe.2019.06.017
   Pittala S, 2018, NEOPLASIA, V20, P594, DOI 10.1016/j.neo.2018.02.012
   Piwkowska A, 2010, BIOCHEM BIOPH RES CO, V393, P268, DOI 10.1016/j.bbrc.2010.01.119
   Polianskyte-Prause Z, 2019, FASEB J, V33, P2858, DOI 10.1096/fj.201800529RR
   Potts MB, 2012, CELL STEM CELL, V11, P5, DOI 10.1016/j.stem.2012.06.003
   Pryor R, 2019, CELL, V178, P1299, DOI 10.1016/j.cell.2019.08.003
   Qiu WQ, 2006, NEUROBIOL AGING, V27, P190, DOI 10.1016/j.neurobiolaging.2005.01.004
   Qu C, 2014, MOL CELL BIOCHEM, V386, P63, DOI 10.1007/s11010-013-1845-x
   Radi E, 2014, J ALZHEIMERS DIS, V42, pS125, DOI 10.3233/JAD-132738
   Raghavan A, 2012, BBA-BIOMEMBRANES, V1818, P1477, DOI 10.1016/j.bbamem.2011.10.019
   Ramos-Penafiel C, 2018, J TRANSL MED, V16, DOI 10.1186/s12967-018-1620-6
   Ranadheera C, 2018, EBIOMEDICINE, V32, P142, DOI 10.1016/j.ebiom.2018.05.027
   Rattan R, 2012, J ONCOL, V2012, DOI 10.1155/2012/928127
   Reina S, 2017, CURR MED CHEM, V24, P4447, DOI 10.2174/0929867324666170530074039
   Rena G, 2018, CIRCULATION, V137, P422, DOI 10.1161/CIRCULATIONAHA.117.031735
   Richardson LC, 2005, NAT CLIN PRACT ONCOL, V2, P48, DOI 10.1038/ncponc0062
   Rizek P, 2016, CAN MED ASSOC J, V188, P1157, DOI 10.1503/cmaj.151179
   Rizos CV, 2013, EUR J PHARMACOL, V705, P96, DOI 10.1016/j.ejphar.2013.02.038
   Roberts DJ, 2013, J BIOL CHEM, V288, P23798, DOI 10.1074/jbc.M113.482026
   Rosa JC, 2016, CURR MOL PHARMACOL, V9, P320, DOI 10.2174/1874467209666160112123036
   Rosario D, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.00775
   Rosencrans WM, 2021, CELL CALCIUM, V95, DOI 10.1016/j.ceca.2021.102355
   Rossi A, 2020, CELL REP, V30, P2332, DOI 10.1016/j.celrep.2020.01.060
   Rostovtseva TK, 2008, J BIOENERG BIOMEMBR, V40, P163, DOI 10.1007/s10863-008-9145-y
   Rostovtseva TK, 2015, J BIOL CHEM, V290, P18467, DOI 10.1074/jbc.M115.641746
   Rotermund C, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00400
   Rottenberg H, 2021, CELLS-BASEL, V10, DOI 10.3390/cells10010079
   Roy SS, 2009, EMBO REP, V10, P1341, DOI 10.1038/embor.2009.219
   Ryu YK, 2018, MOL NEUROBIOL, V55, P5715, DOI 10.1007/s12035-017-0752-7
   Sabirov RZ, 2012, BBA-BIOMEMBRANES, V1818, P1570, DOI 10.1016/j.bbamem.2011.09.024
   Saini N, 2018, ACTA BIOCH BIOPH SIN, V50, P133, DOI 10.1093/abbs/gmx106
   Saisho Y, 2015, ENDOCR METAB IMMUNE, V15, P196, DOI 10.2174/1871530315666150316124019
   Salani B, 2014, ENDOCR-RELAT CANCER, V21, pR461, DOI 10.1530/ERC-14-0284
   Salani B, 2013, SCI REP-UK, V3, DOI 10.1038/srep02070
   Salminen A, 2011, J MOL MED, V89, P667, DOI 10.1007/s00109-011-0748-0
   Sanchez-Rangel E, 2017, DIABETOLOGIA, V60, P1586, DOI 10.1007/s00125-017-4336-x
   Sanchis A, 2019, EXP MOL MED, V51, DOI 10.1038/s12276-019-0264-9
   Sancho P, 2015, CELL METAB, V22, P590, DOI 10.1016/j.cmet.2015.08.015
   Saraei P, 2019, CANCER MANAG RES, V11, P3295, DOI 10.2147/CMAR.S200059
   Saraiva LM, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0015230
   Sasaki K, 2012, AM J PHYSIOL-CELL PH, V303, pC1055, DOI 10.1152/ajpcell.00087.2012
   Scaini G, 2019, NEUROPSYCHOPHARMACOL, V44, P1291, DOI 10.1038/s41386-018-0293-4
   Scheen AJ, 2020, DIABETES METAB, V46, P423, DOI 10.1016/j.diabet.2020.07.006
   Scheen AJ, 2015, DIABETES METAB, V41, P183, DOI 10.1016/j.diabet.2015.02.003
   Scheen AJ, 2013, DIABETES METAB, V39, P179, DOI 10.1016/j.diabet.2013.02.006
   Schirrmacher V, 2020, BIOMEDICINES, V8, DOI 10.3390/biomedicines8110526
   Schwertz H, 2007, PROTEOMICS, V7, P4579, DOI 10.1002/pmic.200700734
   Scully T, 2021, FRONT ONCOL, V10, DOI 10.3389/fonc.2020.615375
   Shafiei-Irannejad V, 2018, CHEM BIOL DRUG DES, V91, P269, DOI 10.1111/cbdd.13078
   Sharma S, 2020, DIABETES RES CLIN PR, V164, DOI 10.1016/j.diabres.2020.108183
   Shaw RJ, 2009, ACTA PHYSIOL, V196, P65, DOI 10.1111/j.1748-1716.2009.01972.x
   Shaw RJ, 2005, SCIENCE, V310, P1642, DOI 10.1126/science.1120781
   Shi Y, 2003, BIOCHEM BIOPH RES CO, V305, P989, DOI 10.1016/S0006-291X(03)00871-4
   Shi Y, 2003, BIOCHEM BIOPH RES CO, V303, P475, DOI 10.1016/S0006-291X(03)00359-0
   Shikata K, 2013, CANCER SCI, V104, P9, DOI 10.1111/cas.12043
   Shimizu S, 1999, NATURE, V399, P483, DOI 10.1038/20959
   Shimizu S, 2000, J BIOL CHEM, V275, P12321, DOI 10.1074/jbc.275.16.12321
   Shitara Y, 2013, TOXICOL SCI, V132, P32, DOI 10.1093/toxsci/kfs330
   Shivavedi N, 2017, BRAIN RES, V1674, P1, DOI 10.1016/j.brainres.2017.08.019
   Shoshan-Barmatz V, 2012, CURR MED CHEM, V19, P714, DOI 10.2174/092986712798992110
   Shoshan-Barmatz V., 2008, CELL SCI, V4, P74
   Shoshan-Barmatz V, 2008, J BIOENERG BIOMEMBR, V40, P183, DOI 10.1007/s10863-008-9147-9
   Shoshan-Barmatz V, 2020, BIOMOLECULES, V10, DOI 10.3390/biom10111485
   Shoshan-Barmatz V, 2017, CELL STRESS, V1, P11, DOI 10.15698/cst2017.10.104
   Shoshan-Barmatz V, 2017, FRONT ONCOL, V7, DOI 10.3389/fonc.2017.00154
   Shoshan-Barmatz V, 2015, BBA-BIOMEMBRANES, V1848, P2547, DOI 10.1016/j.bbamem.2014.10.040
   Shoshan-Barmatz V, 2013, PROG MOL BIOL TRANSL, V117, P303, DOI 10.1016/B978-0-12-386931-9.00011-8
   Shoshan-Barmatz V, 2012, MITOCHONDRION, V12, P24, DOI 10.1016/j.mito.2011.04.001
   Shoshan-Barmatz V, 2010, MOL ASPECTS MED, V31, P227, DOI 10.1016/j.mam.2010.03.002
   Shoshan-Barmatzt V, 2012, FRONT ONCOL, V2, DOI 10.3389/fonc.2012.00164
   Silva DF, 2012, ADV PHARMACOL, V64, P83, DOI 10.1016/B978-0-12-394816-8.00003-9
   Singh KK, 2020, AM J PHYSIOL-CELL PH, V319, pC258, DOI 10.1152/ajpcell.00224.2020
   Sivitz WI, 2010, ANTIOXID REDOX SIGN, V12, P537, DOI 10.1089/ars.2009.2531
   Smilansky A, 2015, J BIOL CHEM, V290, P30670, DOI 10.1074/jbc.M115.691493
   Smith TAD, 2000, BRIT J BIOMED SCI, V57, P170
   Son SM, 2016, J ALZHEIMERS DIS, V51, P1197, DOI 10.3233/JAD-151200
   Sorrentino V, 2018, ANNU REV PHARMACOL, V58, P353, DOI 10.1146/annurev-pharmtox-010716-104908
   Sportelli C, 2020, FRONT NEUROL, V11, DOI 10.3389/fneur.2020.00556
   Suhaimi NAM, 2017, MOL CANCER THER, V16, P2035, DOI 10.1158/1535-7163.MCT-16-0793
   Sultana R, 2006, NEUROBIOL DIS, V22, P76, DOI 10.1016/j.nbd.2005.10.004
   Sun N, 2016, MOL CELL, V61, P654, DOI 10.1016/j.molcel.2016.01.028
   Sun YM, 2020, INT J MED SCI, V17, P2416, DOI 10.7150/ijms.48635
   Tajeddine N, 2008, ONCOGENE, V27, P4221, DOI 10.1038/onc.2008.63
   Tan SY, 2019, DIABETES METAB SYND, V13, P364, DOI 10.1016/j.dsx.2018.10.008
   Thinnes FP, 2011, WIEN MED WOCHENSCHR, V161, P274, DOI 10.1007/s10354-011-0887-5
   Thivolet C, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0182027
   Thompson EA, 2021, CELL REP, V34, DOI 10.1016/j.celrep.2021.108863
   Tian MY, 2019, EUR J PHARMACOL, V843, P80, DOI 10.1016/j.ejphar.2018.11.016
   Tiku V, 2020, TRENDS CELL BIOL, V30, P263, DOI [10.1016/j.tcb.2020.01.006, 10.1016/j.tcb.2020.07.001]
   Titov AA, 2019, J IMMUNOL, V203, P338, DOI 10.4049/jimmunol.1801651
   Tonazzi A, 2015, MINI-REV MED CHEM, V15, P396, DOI 10.2174/138955751505150408142032
   Tong ZH, 2017, BIOMED PHARMACOTHER, V95, P77, DOI 10.1016/j.biopha.2017.08.046
   Tseng CH, 2021, J CROHNS COLITIS, V15, P64, DOI 10.1093/ecco-jcc/jjaa136
   Tseng CH, 2016, AGING-US, V8, P1636, DOI 10.18632/aging.101019
   Ujwal R, 2009, CHANNELS, V3, P167, DOI 10.4161/chan.3.3.9196
   Ujwal R, 2008, P NATL ACAD SCI USA, V105, P17742, DOI 10.1073/pnas.0809634105
   Ursini F, 2020, DIABETES RES CLIN PR, V164, DOI 10.1016/j.diabres.2020.108167
   Valencia WM, 2017, DIABETOLOGIA, V60, P1630, DOI 10.1007/s00125-017-4349-5
   Varughese JT, 2021, CELLS-BASEL, V10, DOI 10.3390/cells10071737
   Verma A., 2021, MOL THER PG
   Vial G, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00294
   Vianello A, 2012, BBA-BIOENERGETICS, V1817, P2072, DOI 10.1016/j.bbabio.2012.06.620
   Viollet B, 2012, CLIN SCI, V122, P253, DOI 10.1042/CS20110386
   Wahlqvist ML, 2012, BMC MED, V10, DOI 10.1186/1741-7015-10-150
   Wahlqvist ML, 2012, PARKINSONISM RELAT D, V18, P753, DOI 10.1016/j.parkreldis.2012.03.010
   Wallace DC, 2005, ANNU REV GENET, V39, P359, DOI 10.1146/annurev.genet.39.110304.095751
   Wallace DC, 2010, ENVIRON MOL MUTAGEN, V51, P440, DOI 10.1002/em.20586
   Wang BZ, 2019, AGING DIS, V10, P1058, DOI 10.14336/AD.2019.0102
   Wang J, 2012, CELL STEM CELL, V11, P23, DOI 10.1016/j.stem.2012.03.016
   Wang SQ, 2019, CANCER BIOL THER, V20, P338, DOI 10.1080/15384047.2018.1529108
   Wang XF, 2011, CLIN EXP PHARMACOL P, V38, P94, DOI 10.1111/j.1440-1681.2010.05470.x
   Weisthal S, 2014, BBA-MOL CELL RES, V1843, P2270, DOI 10.1016/j.bbamcr.2014.03.021
   Wessels B, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100525
   Wijdeven RH, 2016, DRUG RESIST UPDATE, V28, P65, DOI 10.1016/j.drup.2016.07.001
   Wijesekara N, 2018, NEUROPHARMACOLOGY, V136, P172, DOI 10.1016/j.neuropharm.2017.11.027
   Xie JY, 2020, P NATL ACAD SCI USA, V117, P13012, DOI 10.1073/pnas.1918845117
   Yang MY, 2019, MITOCHONDRION, V46, P380, DOI 10.1016/j.mito.2018.10.002
   Yang Y, 2017, BIOCHEM BIOPH RES CO, V484, P450, DOI 10.1016/j.bbrc.2017.01.157
   Yoo BC, 2001, ELECTROPHORESIS, V22, P172, DOI 10.1002/1522-2683(200101)22:1<172::AID-ELPS172>3.0.CO;2-P
   Zaid H, 2005, CELL DEATH DIFFER, V12, P751, DOI 10.1038/sj.cdd.4401599
   Zalk R, 2005, BIOCHEM J, V386, P73, DOI 10.1042/BJ20041356
   Zeng FX, 2018, J MOL CELL CARDIOL, V125, P50, DOI 10.1016/j.yjmcc.2018.10.015
   Zeth K, 2008, J BIOENERG BIOMEMBR, V40, P127, DOI 10.1007/s10863-008-9144-z
   Zeth K, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.00108
   Zhang EM, 2019, CELL METAB, V29, P64, DOI 10.1016/j.cmet.2018.09.008
   Zhang J, 2018, PHARMAZIE, V73, P725, DOI 10.1691/ph.2018.8544
   Zhang WB, 2010, J BIOL CHEM, V285, P40461, DOI 10.1074/jbc.M110.164046
   Zhang XM, 2019, ARCH BIOCHEM BIOPHYS, V672, DOI 10.1016/j.abb.2019.07.026
   Zhang X, 2015, SCI REP-UK, V5, DOI 10.1038/srep14405
   Zhang YH, 2017, EBIOMEDICINE, V18, P157, DOI 10.1016/j.ebiom.2017.03.023
   Zhang ZJ, 2011, DIABETES CARE, V34, P2323, DOI 10.2337/dc11-0512
   Zhao RR, 2014, BIOCHEM BIOPH RES CO, V448, P414, DOI 10.1016/j.bbrc.2014.04.130
   Zhao Y, 2020, AM J RESP CRIT CARE, V202, P756, DOI 10.1164/rccm.202001-0179LE
   Zheng Y, 2018, NAT REV ENDOCRINOL, V14, P88, DOI 10.1038/nrendo.2017.151
   Zimmet P, 2016, NAT REV ENDOCRINOL, V12, P616, DOI 10.1038/nrendo.2016.105
NR 372
TC 16
Z9 16
U1 5
U2 20
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD OCT 4
PY 2021
VL 12
AR 730048
DI 10.3389/fphys.2021.730048
PG 25
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA WV3OZ
UT WOS:000717150400001
PM 34671273
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Su, Y
   Lu, S
   Hou, CJ
   Ren, KH
   Wang, ML
   Liu, XL
   Zhao, SY
   Liu, XP
AF Su, Ying
   Lu, Shan
   Hou, Chenjian
   Ren, Kehan
   Wang, Meili
   Liu, Xiaoli
   Zhao, Shanyu
   Liu, Xiuping
TI Mitigation of liver fibrosis via hepatic stellate cells mitochondrial
   apoptosis induced by metformin
SO INTERNATIONAL IMMUNOPHARMACOLOGY
LA English
DT Article
DE Liver fibrosis; Hepatic stellate cells (HSCs); Metformin; Mitochondrial
   apoptosis; Nonalcoholic steatohepatitis (NASH)
ID GUT MICROBIOME; IN-VIVO; MECHANISMS; MYOFIBROBLASTS; ACTIVATION;
   TARGETS; AMPK
AB Liver fibrosis, a disease characterized by the excessive accumulation of extracellular matrix originating from activated hepatic stellate cells (HSCs), is a common pathological response to chronic liver injury resulting from a variety of insults. However, drugs that effectively block the activation of HSCs have still not been adequately investigated. This study demonstrates that metformin decreased the number of activated-HSCs through induction of apoptosis, but did not impact numbers of hepatocytes. Metformin upregulated BAX activation with facilitation of BIM, BAD and PUMA; downregulated Bcl-2 and Bcl-xl, but did not affect Mcl-1. Additionally, metformin induced cytochrome c release from mitochondria into the cytoplasm, directly triggering caspase-9-mediated mitochondrial apoptosis. The decline in mitochondrial membrane potential (& UDelta;psi m) and deposition of superox -ide in mitochondria accelerated the destruction of the integrity of mitochondrial membrane. Moreover, we verified the therapeutic effect of metformin in our mouse model of liver fibrosis associated with nonalcoholic steatohepatitis (NASH) in which hepatic function, NASH lesions and fibrosis were improved by metformin. In conclusion, this study indicated that metformin has significant therapeutic value in NASH-derived liver fibrosis by inducing apoptosis in HSCs, but does not affect the proliferation of hepatocytes.
C1 [Su, Ying; Lu, Shan; Hou, Chenjian; Ren, Kehan; Liu, Xiaoli; Zhao, Shanyu] Fudan Univ, Sch Basic Med Sci, Dept Pathol, Shanghai 200032, Peoples R China.
   [Wang, Meili] Fudan Univ, Shanghai Peoples Hosp 5, Dept Pathol, Shanghai 200240, Peoples R China.
   [Liu, Xiuping] Fudan Univ, Shanghai Peoples Hosp 5, Sch Basic Med Sci, Dept Pathol, Shanghai 200240, Peoples R China.
C3 Fudan University; Fudan University; Fudan University
RP Liu, XP (通讯作者)，Fudan Univ, Shanghai Peoples Hosp 5, Sch Basic Med Sci, Dept Pathol, Shanghai 200240, Peoples R China.
EM xpliu1228@fudan.edu.cn
RI liu, xiao/HKE-9880-2023; liu, xiao/HMD-7454-2023; Liu,
   Xiaoli/HGE-7614-2022
OI Ren, Kehan/0000-0002-4409-7145
FU Shanghai Natural Science Founda-tion [21ZR1450300]
FX Funding This work was supported by the Shanghai Natural Science
   Founda-tion (No. 21ZR1450300) .
CR Al-Hashem F., J CELL
   Ben Sahra I, 2010, CANCER RES, V70, P2465, DOI 10.1158/0008-5472.CAN-09-2782
   Cha JH, 2018, MOL CELL, V71, P606, DOI 10.1016/j.molcel.2018.07.030
   Chen YH, 2021, ENVIRON TOXICOL, V36, P1491, DOI 10.1002/tox.23146
   Czabotar PE, 2014, NAT REV MOL CELL BIO, V15, P49, DOI 10.1038/nrm3722
   Deng XS, 2012, CELL CYCLE, V11, P367, DOI 10.4161/cc.11.2.18813
   El-Mir MY, 2000, J BIOL CHEM, V275, P223, DOI 10.1074/jbc.275.1.223
   Eslam M, 2020, J HEPATOL, V73, P202, DOI 10.1016/j.jhep.2020.03.039
   Fan KR, 2017, BIOMED PHARMACOTHER, V90, P421, DOI 10.1016/j.biopha.2017.03.079
   Ferretti AC, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-39556-w
   Gao JH, 2020, J HEPATOL, V73, P1144, DOI 10.1016/j.jhep.2020.04.044
   Nguyen G, 2018, BIOCHEM BIOPH RES CO, V495, P2649, DOI 10.1016/j.bbrc.2017.12.143
   Hebbard L, 2011, NAT REV GASTRO HEPAT, V8, P34, DOI 10.1038/nrgastro.2010.191
   Higashi T, 2017, ADV DRUG DELIVER REV, V121, P27, DOI 10.1016/j.addr.2017.05.007
   Howell JJ, 2017, CELL METAB, V25, P463, DOI 10.1016/j.cmet.2016.12.009
   Hunter RW, 2018, NAT MED, V24, P1395, DOI 10.1038/s41591-018-0159-7
   Kauffman Megan E, 2016, React Oxyg Species (Apex), V2, P361, DOI 10.20455/ros.2016.865
   Ke ZL, 2020, J NUTR BIOCHEM, V83, DOI 10.1016/j.jnutbio.2020.108426
   Kheirollahi V, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-10839-0
   Kisseleva T, 2021, NAT REV GASTRO HEPAT, V18, P151, DOI 10.1038/s41575-020-00372-7
   Lee G, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-18754-5
   Li DR, 2019, MOL CELL, V75, P1103, DOI 10.1016/j.molcel.2019.06.040
   Li Z, 2018, WORLD J GASTROENTERO, V24, P819, DOI 10.3748/wjg.v24.i7.819
   Ma T, 2022, NATURE, V603, P159, DOI 10.1038/s41586-022-04431-8
   Ma ZJ, 2018, EUR J PHARMACOL, V821, P1, DOI 10.1016/j.ejphar.2017.12.027
   Madiraju AK, 2014, NATURE, V510, P542, DOI 10.1038/nature13270
   Martinou JC, 2011, DEV CELL, V21, P92, DOI 10.1016/j.devcel.2011.06.017
   Matsumoto M, 2013, INT J EXP PATHOL, V94, P93, DOI 10.1111/iep.12008
   Rangarajan S, 2018, NAT MED, V24, P1121, DOI 10.1038/s41591-018-0087-6
   Rena G, 2017, DIABETOLOGIA, V60, P1577, DOI 10.1007/s00125-017-4342-z
   Sanchez-Rangel E, 2017, DIABETOLOGIA, V60, P1586, DOI 10.1007/s00125-017-4336-x
   Schuppan D, 2018, MATRIX BIOL, V68-69, P435, DOI 10.1016/j.matbio.2018.04.006
   Shen YQ, 2018, J PINEAL RES, V64, DOI 10.1111/jpi.12461
   Simon TG, 2021, HEPATOLOGY, V73, P2063, DOI 10.1002/hep.31660
   Song GQ, 2016, CELL STEM CELL, V18, P797, DOI 10.1016/j.stem.2016.01.010
   Song RS, 2016, DIABETES CARE, V39, P187, DOI 10.2337/dci15-0013
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Sun RJ, 2020, CANCER MED-US, V9, P1141, DOI 10.1002/cam4.2723
   Thakur S., VITRO
   Tikoo K, 2016, J BIOL CHEM, V291, P21848, DOI 10.1074/jbc.C116.732990
   Troeger JS, 2012, GASTROENTEROLOGY, V143, P1073, DOI 10.1053/j.gastro.2012.06.036
   Tsuchida T, 2017, NAT REV GASTRO HEPAT, V14, P397, DOI 10.1038/nrgastro.2017.38
   Wang QL, 2017, DIABETES, V66, P193, DOI 10.2337/db16-0915
   Wang Y, 2019, CELL REP, V29, P1511, DOI 10.1016/j.celrep.2019.09.070
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Zhou M., 2022, OXID MED CELL LONGEV, V2022, P1
   Zhou WC, 2014, WORLD J GASTROENTERO, V20, P7312, DOI 10.3748/wjg.v20.i23.7312
NR 47
TC 1
Z9 1
U1 4
U2 9
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1567-5769
EI 1878-1705
J9 INT IMMUNOPHARMACOL
JI Int. Immunopharmacol.
PD JUL
PY 2022
VL 108
AR 108683
DI 10.1016/j.intimp.2022.108683
EA MAR 2022
PG 13
WC Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Pharmacology & Pharmacy
GA 1C5ZW
UT WOS:000793197900002
PM 35344814
OA hybrid
DA 2023-06-08
ER

PT J
AU Molina-Vega, M
   Picon-Cesar, MJ
   Gutierrez-Repiso, C
   Fernandez-Valero, A
   Lima-Rubio, F
   Gonzalez-Romero, S
   Moreno-Indias, I
   Tinahones, FJ
AF Molina-Vega, Maria
   Picon-Cesar, Maria J.
   Gutierrez-Repiso, Carolina
   Fernandez-Valero, Andrea
   Lima-Rubio, Fuensanta
   Gonzalez-Romero, Stella
   Moreno-Indias, Isabel
   Tinahones, Francisco J.
TI Metformin action over gut microbiota is related to weight and glycemic
   control in gestational diabetes mellitus: A randomized trial
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Gestational diabetes; Metformin; Insulin; Gut microbiota; Weight gain;
   Metabolic control
AB Background: Metformin, which is known to produce profound changes in gut micmbiota, is being increasingly used in gestational diabetes mellitus (GDM). The aim of this study was to elucidate the differences in gut microbiota composition and function in women with GDM treated with metformin compared to those treated with insulin.
   Methods: From May to December 2018, 58 women with GDM were randomized to receive insulin (INS; n = 28) or metformin (MET; n = 30) at the University Hospital Virgen de la Victoria, Malaga, Spain. Basal visits, with at least 1 follow-up visit and prepartum visit, were performed. At the basal and prepartum visits, blood and stool samples were collected. The gut microbiota profile was determined through 16S rRNA analysis.
   Results: Compared to INS, women on MET presented a lower mean postprandial glycemia and a lower increase in weight and body mass index (BMI). Firmicutes and Peptostreptococcaceae abundance declined, while Proteobacteria and Enterobacteriaceae abundance increased in the MET group. We found inverse correlations between changes in the abundance of Proteobacteria and mean postprandial glycemia (p = 0.023), as well as between Enterobacteriaceae and a rise in BMI and weight gain (p = 0.031 and p = 0.036, respectively). Regarding the metabolic profile of gut microbiota, predicted metabolic pathways related to propionate degradation and ubiquinol biosynthesis predominated in the MET group.
   Conclusion: Metformin in GDM affects the composition and metabolic profile of gut microbiota. These changes could mediate, at least in part, its clinical effects. Studies designed to assess how these changes influence metabolic control during and after pregnancy are necessary.
C1 [Molina-Vega, Maria; Picon-Cesar, Maria J.; Fernandez-Valero, Andrea; Tinahones, Francisco J.] Hosp Univ Virgen Victoria, Dept Endocrinol & Nutr, Malaga, Spain.
   [Molina-Vega, Maria; Gutierrez-Repiso, Carolina; Lima-Rubio, Fuensanta; Moreno-Indias, Isabel; Tinahones, Francisco J.] Univ Malaga, Virgen Victoria Univ Hosp, Lab Biomed Res Inst Malaga, Malaga, Spain.
   [Gutierrez-Repiso, Carolina; Moreno-Indias, Isabel; Tinahones, Francisco J.] Inst Salud Carlos III, Ctr Invest Biomed Red CIBER Fisiopatol Obesidad &, Madrid, Spain.
   [Gonzalez-Romero, Stella] Hosp Reg Univ Carlos Haya, Dept Endocrinol & Nutr, Malaga, Spain.
C3 Hospital Virgen de la Victoria; Instituto de Investigacion Biomedica de
   Malaga y Plataforma en Nanomedicina (IBIMA); Universidad de Malaga;
   CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN; Instituto de
   Salud Carlos III; Hospital Carlos Haya
RP Moreno-Indias, I (通讯作者)，Hosp Clin Univ Virgen Victoria, Lab Invest Biomed 1a Planta, Campus Teatinos S-N, Malaga 29010, Spain.
EM isabel.moreno@ibima.eu
RI Gutiérrez-Repiso, Carolina/F-8125-2010; Molina-Vega,
   María/GQA-5234-2022; Moreno-Indias, Isabel/B-6595-2017
OI Gutiérrez-Repiso, Carolina/0000-0002-5842-8873; Moreno-Indias,
   Isabel/0000-0002-6121-151X; Tinahones, Francisco J/0000-0001-6871-4403
FU Consejeria de Salud y Familias de la Junta de Andalucia: Financiacion de
   la Investigacion Biomedica y en Ciencias de la Salud en Andalucia para
   el ano 2019, Linea de proyectos de Investigacion, Desarrollo e
   Innovacion Biomedica y en Ciencias de la Salud, M [PI0419-2019];
   Fundacion SED (Sociedad Espanola de Diabetes): IX Ayuda SED a Proyectos
   de Investigacion Clinica en Diabetes dirigidos por Jovenes
   Investigadores en 2018; Juan Rodes program from Instituto de Salud
   Carlos III [JR20-00040]; Juan de la Cierva program from the Ministerio
   de Ciencia e Innovacion [IJCI-2017-33065]; Miguel Servet Type I program
   from the Instituto de Salud Carlos III - Fondo Europeo de Desarrollo
   Regional [CP16/00163]; "Centros de Investigacion Biomedica en Red"
   (CIBER) of the Instituto de Salud Carlos III (ISCIII) [CB06/03/ 0018];
   ISCIII [PI18/01160, PI21/01677]; European Regional Development Fund
   (ERDF)
FX This study was supported by the Consejeria de Salud y Familias de la
   Junta de Andalucia: Financiacion de la Investigacion Biomedica y en
   Ciencias de la Salud en Andalucia para el ano 2019, Linea de proyectos
   de Investigacion, Desarrollo e Innovacion Biomedica y en Ciencias de la
   Salud, Modalidad proyectos de investigacion en salud (PI0419-2019) and
   Fundacion SED (Sociedad Espanola de Diabetes): IX Ayuda SED a Proyectos
   de Investigacion Clinica en Diabetes dirigidos por Jovenes
   Investigadores en 2018. This study was also supported by the Juan Rodes
   program from Instituto de Salud Carlos III (JR20-00040 to MMV), the Juan
   de la Cierva program from the Ministerio de Ciencia e Innovacion
   (IJCI-2017-33065 to CG-R) and the Miguel Servet Type I program from the
   Instituto de Salud Carlos III cofounded by the Fondo Europeo de
   Desarrollo Regional (CP16/00163 to IM-I). In addition, this study was
   supported by the "Centros de Investigacion Biomedica en Red" (CIBER) of
   the Instituto de Salud Carlos III (ISCIII) (CB06/03/ 0018), and research
   grants from the ISCIII (PI18/01160; PI21/01677)) and co-financed by the
   European Regional Development Fund (ERDF).
CR American Diabetes Association, 2020, DIABETES CARE, V43, pS187
   Balint A, 2020, PHARMACEUTICALS-BASE, V13, DOI 10.3390/ph13110346
   Bolyen E, 2019, NAT BIOTECHNOL, V37, P852, DOI 10.1038/s41587-019-0209-9
   Borgo F, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0179739
   Bryrup T, 2019, DIABETOLOGIA, V62, P1024, DOI 10.1007/s00125-019-4848-7
   Callahan BJ, 2016, NAT METHODS, V13, P581, DOI [10.1038/NMETH.3869, 10.1038/nmeth.3869]
   Caspi R, 2018, NUCLEIC ACIDS RES, V46, pD633, DOI 10.1093/nar/gkx935
   Chassard C, 2008, INT J SYST EVOL MICR, V58, P1008, DOI 10.1099/ijs.0.65504-0
   Clarke SF, 2012, GUT MICROBES, V3, P186, DOI 10.4161/gmic.20168
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Dhariwal A, 2017, NUCLEIC ACIDS RES, V45, pW180, DOI 10.1093/nar/gkx295
   Dominique M, 2019, NUTRIENTS, V11, DOI 10.3390/nu11102514
   Ejtahed HS, 2019, EUR J ENDOCRINOL, V180, P165, DOI [10.1530/EJE-18-0826, 10.1530/eje-18-0826]
   El Hage R, 2019, FRONT MICROBIOL, V10, DOI 10.3389/fmicb.2019.01206
   Elbere I, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0204317
   Feng Y., 2017, J MATERN-FETAL NEO M, V30, P1874, DOI [10.1080/14767058.2016.1228061, DOI 10.1080/14767058.2016.1228061]
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   HARRIS M, 1979, DIABETES, V28, P1039
   Hasain Z, 2020, FRONT CELL INFECT MI, V10, DOI 10.3389/fcimb.2020.00188
   Huang F, 2018, INT J FOOD SCI NUTR, V69, P729, DOI 10.1080/09637486.2017.1408059
   Johns EC, 2018, TRENDS ENDOCRIN MET, V29, P743, DOI 10.1016/j.tem.2018.09.004
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Koren O, 2012, CELL, V150, P470, DOI 10.1016/j.cell.2012.07.008
   Lee Y, 2021, DIABETES RES CLIN PR, V178, DOI 10.1016/j.diabres.2021.108985
   Legrand R, 2020, INT J OBESITY, V44, P1041, DOI 10.1038/s41366-019-0515-9
   Lordan C, 2020, GUT MICROBES, V11, P1, DOI 10.1080/19490976.2019.1613124
   Mahnic A, 2020, FRONT MICROBIOL, V11, DOI 10.3389/fmicb.2020.00120
   Mendez-Figueroa H, 2017, OBSTET GYNECOL, V130, P163, DOI 10.1097/AOG.0000000000002101
   Metzger BE, 1998, DIABETES CARE, V21, pB161
   National Institute for Health and Care Excellence (NICE), 2015, TYP 2 DIAB AD MAN
   Oliveira A, 2021, PLOS COMPUT BIOL, V17, DOI 10.1371/journal.pcbi.1008704
   Paganelli FL, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-47332-z
   Parks DH, 2014, BIOINFORMATICS, V30, P3123, DOI 10.1093/bioinformatics/btu494
   Pickard JM, 2017, IMMUNOL REV, V279, P70, DOI 10.1111/imr.12567
   Picon-Cesar M.J., 2021, AM J OBSTET GYNECOL, P00459
   Ponzo V, 2019, NUTRIENTS, V11, DOI 10.3390/nu11020330
   Ravcheev DA, 2016, FRONT MICROBIOL, V7, DOI 10.3389/fmicb.2016.00128
   Sanna S, 2019, NAT GENET, V51, P600, DOI 10.1038/s41588-019-0350-x
   Santacruz A, 2010, BRIT J NUTR, V104, P83, DOI 10.1017/S0007114510000176
   Segata N, 2011, GENOME BIOL, V12, DOI 10.1186/gb-2011-12-6-r60
   Sililas P, 2021, MICROORGANISMS, V9, DOI 10.3390/microorganisms9081686
   Simonte FM, 2017, MOL MICROBIOL, V103, P55, DOI 10.1111/mmi.13541
   Soc Maternal-Fetal Med SMFM, 2018, AM J OBSTET GYNECOL, V218, pB2, DOI 10.1016/j.ajog.2018.01.041
   Valles-Colomer M, 2019, NAT MICROBIOL, V4, P623, DOI 10.1038/s41564-018-0337-x
   Wang HD, 2020, ACTA DIABETOL, V57, P455, DOI 10.1007/s00592-019-01436-0
   Wirbel J, 2019, NAT MED, V25, P679, DOI 10.1038/s41591-019-0406-6
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Yamashita T, 2017, J ATHEROSCLER THROMB, V24, P110, DOI 10.5551/jat.38265
NR 48
TC 5
Z9 5
U1 2
U2 10
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD JAN
PY 2022
VL 145
AR 112465
DI 10.1016/j.biopha.2021.112465
EA NOV 2021
PG 9
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA XG7LB
UT WOS:000724929300007
PM 34844107
OA gold
DA 2023-06-08
ER

PT J
AU Torres, W
   Nava, M
   Galban, N
   Gomez, Y
   Morillo, V
   Rojas, M
   Cano, C
   Chacin, M
   D'Marco, L
   Herazo, Y
   Velasco, M
   Bermudez, V
   Rojas-Quintero, J
AF Torres, Wheeler
   Nava, Manuel
   Galban, Nestor
   Gomez, Yosselin
   Morillo, Valery
   Rojas, Milagros
   Cano, Climaco
   Chacin, Maricarmen
   D'Marco, Luis
   Herazo, Yaneth
   Velasco, Manuel
   Bermudez, Valmore
   Rojas-Quintero, Joselyn
TI Anti-Aging Effect of Metformin: A Molecular and Therapeutical
   Perspective
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Review
DE Metformin; ageing; anti-ageing drugs; Type 2 diabetes mellitus;
   geronto-protective properties; cellular homeostasis
ID ACTIVATED PROTEIN-KINASE; EXTENDS LIFE-SPAN; MITOCHONDRIAL-FUNCTION;
   AUTOPHAGY INDUCTION; CALORIC RESTRICTION; DNA-DAMAGE; STEM-CELLS; AMPK;
   MORTALITY; RAPAMYCIN
AB Aging is a time-dependent inevitable process, in which cellular homeostasis is affected, which has an impact on tissue function. This represents a risk factor for the development of numerous non-transmissible diseases. In consequence, the scientific community continues to search for therapeutic measures capable of improving quality of life and delaying cellular aging. At the center of this research is metformin, a widely used drug in Type 2 Diabetes Mellitus treatment that has a reduced adverse effects profile. Furthermore, there is evidence that this drug has beneficial health effects that go beyond its anti-hyperglycemic properties. Among these effects, its geronto-protection capability stands out. There is growing evidence that points out to an increased life expectancy as well as the quality of life in model organisms treated with metformin. Therefore, there is an abundance of research centered on elucidating the mechanism through which metformin has its anti-aging effects. Among these, the AMPK, mTORC1, SIRT1, FOXO, NF.kB, and DICER1 pathways can be mentioned. Furthermore, studies have highlighted the possibility of a role for the gut microbiome in these processes. The next step is the design of clinical essays that have as a goal evaluating the efficacy and safety of metformin as an anti-aging drug in humans to create a paradigm in the medical horizon. The question being if metformin is, in fact, the new anti-aging therapy in humans?
C1 [Torres, Wheeler; Nava, Manuel; Galban, Nestor; Gomez, Yosselin; Morillo, Valery; Rojas, Milagros; Cano, Climaco] Univ Zulia, Endocrine & Metab Dis Res Ctr, Sch Med, 20th Ave 4004, Maracaibo, Venezuela.
   [Chacin, Maricarmen; Herazo, Yaneth; Bermudez, Valmore] Univ Simon Bolivar, Fac Ciencias Salud, Barranquilla, Colombia.
   [D'Marco, Luis] Hosp Clin Univ, Nephrol Dept, INCLIVA, Valencia, Spain.
   [Velasco, Manuel] Univ Cent Venezuela, Vargas Sch Med, Clin Pharmacol Unit, Caracas, Venezuela.
   [Rojas-Quintero, Joselyn] Harvard Med Sch, Brigham & Womens Hosp, Pulm & Crit Care Med Dept, Boston, MA 02115 USA.
C3 University of Central Venezuela; Harvard University; Brigham & Women's
   Hospital; Harvard Medical School
RP Torres, W (通讯作者)，Univ Zulia, Endocrine & Metab Dis Res Ctr, Sch Med, 20th Ave 4004, Maracaibo, Venezuela.
EM wheelertorres16@gmail.com
RI D'MARCO, LUIS/E-8210-2015; Bermudez, Valmore/E-3517-2018; Bermudez,
   Valmore/K-4721-2019; D'Marco, Luis/GPX-1036-2022; Bermudez,
   Valmore/HLH-6291-2023
OI D'MARCO, LUIS/0000-0003-0148-891X; Bermudez,
   Valmore/0000-0003-1880-8887; Bermudez, Valmore/0000-0003-1880-8887;
   D'Marco, Luis/0000-0003-0148-891X; Bermudez,
   Valmore/0000-0003-1880-8887; Rojas-Quintero, Joselyn
   Joanna/0000-0003-4994-075X; Torres, Wheeler/0000-0002-7068-0190; Gomez,
   Yosselin/0000-0003-2146-4560; Nava, Manuel/0000-0001-9769-1693; Rojas,
   Milagros/0000-0003-2764-8846; Herazo-Beltran,
   Yaneth/0000-0003-3752-4353; Galban, Nestor/0000-0003-0765-2290; Chacin,
   Maricarmen/0000-0002-5208-9401
CR Aghaalikhani N, 2017, AVICENNA J MED BIOCH, V5, P22, DOI DOI 10.15171/AJMB.2017.04
   Albert V, 2015, CURR OPIN CELL BIOL, V33, P55, DOI 10.1016/j.ceb.2014.12.001
   Amin S, 2019, BRIT J CLIN PHARMACO, V85, P37, DOI 10.1111/bcp.13780
   Anisimov VN, 2008, CELL CYCLE, V7, P2769, DOI 10.4161/cc.7.17.6625
   Anisimov VN, 2015, CELL CYCLE, V14, P46, DOI 10.4161/15384101.2014.973308
   Anisimov VN, 2013, CRIT REV ONCOL HEMAT, V87, P201, DOI 10.1016/j.critrevonc.2013.01.005
   Anisimov VN, 2011, AGING-US, V3, P148, DOI 10.18632/aging.100273
   Anisimov VN, 2005, B EXP BIOL MED+, V139, P721, DOI 10.1007/s10517-005-0389-9
   Anton S, 2013, EXP GERONTOL, V48, P1003, DOI 10.1016/j.exger.2013.04.011
   Arguelles S, 2019, ANN NY ACAD SCI, V1443, P20, DOI 10.1111/nyas.14020
   Aunan JR, 2016, BRIT J SURG, V103, pE29, DOI 10.1002/bjs.10053
   Bailey CJ, 2017, DIABETOLOGIA, V60, P1566, DOI 10.1007/s00125-017-4318-z
   Bannister CA, 2014, DIABETES OBES METAB, V16, P1165, DOI 10.1111/dom.12354
   Bartke A, 2011, EXP GERONTOL, V46, P108, DOI 10.1016/j.exger.2010.08.020
   Bartke A, 2011, PHILOS T R SOC B, V366, P28, DOI 10.1098/rstb.2010.0281
   Barzilai N, 2016, CELL METAB, V23, P1060, DOI 10.1016/j.cmet.2016.05.011
   Batandier C, 2006, J BIOENERG BIOMEMBR, V38, P33, DOI 10.1007/s10863-006-9003-8
   Bielas J, 2018, EXP GERONTOL, V106, P125, DOI 10.1016/j.exger.2018.02.021
   Bo S, 2012, DIABETES OBES METAB, V14, P23, DOI 10.1111/j.1463-1326.2011.01480.x
   Bonafe M, 2020, AGEING RES REV, V59, DOI 10.1016/j.arr.2020.101027
   Bonfili L, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-02587-2
   Brandsma E, 2019, CIRC RES, V124, P94, DOI 10.1161/CIRCRESAHA.118.313234
   Brutsaert E., 2018, METFORMIN LONGEVITY
   Cabreiro F, 2013, CELL, V153, P228, DOI 10.1016/j.cell.2013.02.035
   Cameron AR, 2018, REDOX BIOL, V14, P187, DOI 10.1016/j.redox.2017.08.018
   Campbell JM, 2017, AGEING RES REV, V40, P31, DOI 10.1016/j.arr.2017.08.003
   Canto C, 2009, NATURE, V458, P1056, DOI 10.1038/nature07813
   Chen J, 2017, ELIFE, V6, DOI 10.7554/eLife.31268
   Chung CL, 2019, GEROSCIENCE, V41, P861, DOI 10.1007/s11357-019-00113-y
   Clements A, 2011, ANN ONCOL, V22, P2556, DOI 10.1093/annonc/mdr037
   Corrales P, 2019, AGING CELL, V18, DOI 10.1111/acel.12948
   Cree-Green M, 2019, J CLIN ENDOCR METAB, V104, P3265, DOI 10.1210/jc.2019-00129
   Cui YZ, 2019, INT IMMUNOPHARMACOL, V75, DOI 10.1016/j.intimp.2019.105822
   Cuyas E, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00657
   da Costa JP, 2016, AGEING RES REV, V29, P90, DOI 10.1016/j.arr.2016.06.005
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Ehninger D, 2014, CELL MOL LIFE SCI, V71, P4325, DOI 10.1007/s00018-014-1677-1
   Fang JQ, 2018, AGING CELL, V17, DOI 10.1111/acel.12765
   Farr SA, 2019, J ALZHEIMERS DIS, V68, P1699, DOI 10.3233/JAD-181240
   Fatemi I, 2018, FUND CLIN PHARMACOL, V32, P392, DOI 10.1111/fcp.12364
   Fatemi I, 2018, IRAN J BASIC MED SCI, V21, P19, DOI 10.22038/IJBMS.2017.24331.6071
   Fernandes M, 2016, HUM MOL GENET, V25, P4804, DOI 10.1093/hmg/ddw307
   Ferreira RM, 2018, GUT, V67, P226, DOI 10.1136/gutjnl-2017-314205
   Florez JC, 2017, DIABETOLOGIA, V60, P1648, DOI 10.1007/s00125-017-4335-y
   Flynn MG, 2019, AGING DIS, V10, P147, DOI 10.14336/AD.2018.0326
   Foulkes WD, 2014, NAT REV CANCER, V14, P662, DOI 10.1038/nrc3802
   Franceschi C, 2007, MECH AGEING DEV, V128, P92, DOI 10.1016/j.mad.2006.11.016
   Fulop T, 2018, FRONT IMMUNOL, V8, DOI 10.3389/fimmu.2017.01960
   Gabande-Rodriguez E, 2020, CELLS-BASEL, V9, DOI 10.3390/cells9010082
   Gandini S, 2014, CANCER PREV RES, V7, P867, DOI 10.1158/1940-6207.CAPR-13-0424
   Garg G, 2017, REJUV RES, V20, P173, DOI 10.1089/rej.2016.1883
   Garg G, 2017, REJUV RES, V20, P16, DOI 10.1089/rej.2016.1826
   Glossmann HH, 2019, GERONTOLOGY, V65, P581, DOI 10.1159/000502257
   Golbidi S, 2017, CURR DIABETES REP, V17, DOI 10.1007/s11892-017-0951-7
   Gowans GJ, 2013, CELL METAB, V18, P556, DOI 10.1016/j.cmet.2013.08.019
   Granado M, 2019, NUTR METAB CARDIOVAS, V29, P97, DOI 10.1016/j.numecd.2018.09.005
   Guo RY, 2017, CELL, V170, P1247, DOI 10.1016/j.cell.2017.07.050
   Hardie DG, 2016, TRENDS CELL BIOL, V26, P190, DOI 10.1016/j.tcb.2015.10.013
   Harrison DE, 2009, NATURE, V460, P392, DOI 10.1038/nature08221
   He L, 2015, CELL METAB, V21, P159, DOI 10.1016/j.cmet.2015.01.003
   Hillson Olivia, 2018, BioMolecular Concepts, V9, P200, DOI 10.1515/bmc-2018-0018
   Houthoofd K, 2006, EXP GERONTOL, V41, P1026, DOI 10.1016/j.exger.2006.05.007
   Howell JJ, 2017, CELL METAB, V25, P463, DOI 10.1016/j.cmet.2016.12.009
   Huang WY, 2017, CLIN DRUG INVEST, V37, P991, DOI 10.1007/s40261-017-0564-6
   Huo YL, 2011, BIOCHEM SOC T, V39, P446, DOI 10.1042/BST0390446
   Jang SG, 2020, RHEUMATOLOGY, V59, P1426, DOI 10.1093/rheumatology/kez631
   Jeon SM, 2016, EXP MOL MED, V48, DOI 10.1038/emm.2016.81
   Jin CC, 2019, CELL, V176, P998, DOI 10.1016/j.cell.2018.12.040
   Jing YY, 2018, MOL CELL ENDOCRINOL, V461, P256, DOI 10.1016/j.mce.2017.09.025
   Joseph AM, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0069327
   Justice JN, 2018, GEROSCIENCE, V40, P419, DOI 10.1007/s11357-018-0042-y
   Kalender A, 2010, CELL METAB, V11, P390, DOI 10.1016/j.cmet.2010.03.014
   Kapuy O, 2014, FEBS OPEN BIO, V4, P704, DOI 10.1016/j.fob.2014.07.006
   Katsimpardi L, 2014, SCIENCE, V344, P630, DOI 10.1126/science.1251141
   Kim DH, 2015, BIOGERONTOLOGY, V16, P1, DOI 10.1007/s10522-014-9519-y
   Kim MJ, 2019, EXP GERONTOL, V125, DOI 10.1016/j.exger.2019.110675
   Kucia M, 2019, ADV EXP MED BIOL, V1201, P355, DOI 10.1007/978-3-030-31206-0_15
   Labbadia J, 2015, ANNU REV BIOCHEM, V84, P435, DOI 10.1146/annurev-biochem-060614-033955
   Larsen S, 2012, DIABETOLOGIA, V55, P443, DOI 10.1007/s00125-011-2340-0
   Le S, 2019, CLIN DRUG INVEST, V39, P757, DOI 10.1007/s40261-019-00799-0
   Li FF, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-01719-y
   Lockwood TD, 2010, EXPERT OPIN THER TAR, V14, P467, DOI 10.1517/14728221003774135
   Logie L, 2012, DIABETES, V61, P1423, DOI 10.2337/db11-0961
   Long DE, 2017, TRIALS, V18, DOI 10.1186/s13063-017-1932-5
   Lopez-Otin C, 2013, CELL, V153, P1194, DOI 10.1016/j.cell.2013.05.039
   Madiraju AK, 2018, NAT MED, V24, P1384, DOI 10.1038/s41591-018-0125-4
   Markowicz-Piasecka M, 2017, PHARM RES-DORDR, V34, P2614, DOI 10.1007/s11095-017-2199-y
   Martin-Montalvo A, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms3192
   Martins R, 2016, AGING CELL, V15, P196, DOI 10.1111/acel.12427
   McGuire C, 2017, FRONT BIOSCI-LANDMRK, V22, P609, DOI 10.2741/4506
   Mohajeri MH, 2018, EUR J NUTR, V57, pS1, DOI 10.1007/s00394-018-1703-4
   Moiseeva O, 2013, AGING CELL, V12, P489, DOI 10.1111/acel.12075
   Morley JE, 2018, ALZHEIMERS DEMENT 1, V14, pP1141, DOI DOI 10.1016/JJALZ.2018.06.1551
   Morrison EJ, 2019, NUTRIENTS, V11, DOI 10.3390/nu11061337
   Moskalev AA, 2013, AGEING RES REV, V12, P661, DOI 10.1016/j.arr.2012.02.001
   Na HJ, 2015, MECH AGEING DEV, V149, P8, DOI 10.1016/j.mad.2015.05.004
   Na HJ, 2013, MECH AGEING DEV, V134, P381, DOI 10.1016/j.mad.2013.07.003
   Napolitano A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100778
   Neumann B, 2019, CELL STEM CELL, V25, P473, DOI 10.1016/j.stem.2019.08.015
   Ng TP, 2014, J ALZHEIMERS DIS, V41, P61, DOI 10.3233/JAD-131901
   Noren Hooten N, 2016, AGING CELL, V15, P572, DOI 10.1111/acel.12469
   Novelle MG, 2016, CSH PERSPECT MED, V6, DOI 10.1101/cshperspect.a025932
   Onken B, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0008758
   Owen MR, 2000, BIOCHEM J, V348, P607, DOI 10.1042/0264-6021:3480607
   Papadopoli David, 2019, F1000Res, V8, DOI 10.12688/f1000research.17196.1
   Parmar N, 2010, ENZYMES, V27, P39, DOI 10.1016/S1874-6047(10)27003-8
   Parzych KR, 2014, ANTIOXID REDOX SIGN, V20, P460, DOI 10.1089/ars.2013.5371
   Pearce EL, 2009, NATURE, V460, P103, DOI 10.1038/nature08097
   Picca A, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18050933
   Piskovatska Veronika, 2019, Subcell Biochem, V91, P339, DOI 10.1007/978-981-13-3681-2_13
   PIZZINO G, 2017, OXID MED CELL LONGEV, V2017, DOI DOI 10.1155/2017/8416763
   Pluquet O, 2015, AM J PHYSIOL-CELL PH, V308, pC415, DOI 10.1152/ajpcell.00334.2014
   Podhorecka M, 2017, POSTEP HIG MED DOSW, V71, P170
   Potempa M, 2016, CLIN DIABETOL, V5, P117, DOI 10.5603/DK.2016.0020
   Qian MX, 2018, ADV EXP MED BIOL, V1086, P235, DOI 10.1007/978-981-13-1117-8_15
   Qin X, 2019, AGING-US, V11, P3785, DOI 10.18632/aging.102016
   Rana A, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-00525-4
   Rea IM, 2018, FRONT IMMUNOL, V9, DOI 10.3389/fimmu.2018.00586
   Ren HW, 2020, MOL CELL ENDOCRINOL, V500, DOI 10.1016/j.mce.2019.110628
   Ridlon JM, 2016, GUT MICROBES, V7, P22, DOI 10.1080/19490976.2015.1127483
   Rivera-Torres J, 2013, J PROTEOMICS, V91, P466, DOI 10.1016/j.jprot.2013.08.008
   Sambe T, 2018, BIOMED PHARMACOTHER, V98, P149, DOI 10.1016/j.biopha.2017.12.023
   Samy M, 2018, ADV MED & MED RES, V1, P49, DOI DOI 10.31377/AMMR.V1I1.497
   Sanchez-Alvarez M, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-16662-1
   Scheen AJ, 2008, EXPERT OPIN INV DRUG, V17, P263, DOI 10.1517/13543784.17.3.263 
   Short KR, 2005, P NATL ACAD SCI USA, V102, P5618, DOI 10.1073/pnas.0501559102
   Shu Y, 2007, J CLIN INVEST, V117, P1422, DOI 10.1172/JCI30558
   Slack C, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0047699
   Song JB, 2019, AGING-US, V11, P240, DOI 10.18632/aging.101746
   Song YM, 2015, AUTOPHAGY, V11, P46, DOI 10.4161/15548627.2014.984271
   Soukas AA, 2019, TRENDS ENDOCRIN MET, V30, P745, DOI 10.1016/j.tem.2019.07.015
   Templeman NM, 2018, J CELL BIOL, V217, P93, DOI 10.1083/jcb.201707168
   Theurey P, 2018, GENES-BASEL, V9, DOI 10.3390/genes9010022
   Toyama EQ, 2016, SCIENCE, V351, P275, DOI 10.1126/science.aab4138
   Valencia WM, 2017, DIABETOLOGIA, V60, P1630, DOI 10.1007/s00125-017-4349-5
   Vallianou NG, 2019, HORM-INT J ENDOCRINO, V18, P141, DOI 10.1007/s42000-019-00093-w
   Vinothkumar KR, 2014, NATURE, V515, P80, DOI 10.1038/nature13686
   Wang T, 2020, CLIN EPIGENETICS, V12, DOI 10.1186/s13148-019-0801-3
   Wang Y, 2019, CELL REP, V29, P1511, DOI 10.1016/j.celrep.2019.09.070
   Watanabe CK, 1918, J BIOL CHEM, V33, P253
   Werner EA, 1922, J CHEM SOC, V121, P1790, DOI 10.1039/ct9222101790
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Xia SJ, 2016, J IMMUNOL RES, V2016, DOI 10.1155/2016/8426874
   Xu HX, 2015, ANNU REV PHYSIOL, V77, P57, DOI 10.1146/annurev-physiol-021014-071649
   Yin M, 2013, ONCOLOGIST, V18, P1248, DOI 10.1634/theoncologist.2013-0111
   Yin ZR, 2018, FRONT MOL NEUROSCI, V11, DOI 10.3389/fnmol.2018.00065
   Yuan YJ, 2016, MECH AGEING DEV, V155, P10, DOI 10.1016/j.mad.2016.02.003
   Zhang CS, 2016, CELL METAB, V24, P521, DOI 10.1016/j.cmet.2016.09.003
   Zhang CS, 2014, CELL METAB, V20, P526, DOI 10.1016/j.cmet.2014.06.014
   Zhao JH, 2015, P NATL ACAD SCI USA, V112, P15790, DOI 10.1073/pnas.1521919112
   Zhao P, 2017, AGING CELL, V16, P1083, DOI 10.1111/acel.12635
   Zhou J, 2017, AGING-US, V9, P583, DOI 10.18632/aging.101181
NR 152
TC 10
Z9 10
U1 1
U2 17
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PY 2020
VL 26
IS 35
BP 4496
EP 4508
DI 10.2174/1381612826666200716161610
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA OH3WJ
UT WOS:000582502300012
PM 32674728
DA 2023-06-08
ER

PT J
AU Pryor, R
   Norvaisas, P
   Marinos, G
   Best, L
   Thingholm, LB
   Quintaneiro, LM
   De Haes, W
   Esser, D
   Waschina, S
   Lujan, C
   Smith, RL
   Scott, TA
   Martinez-Martinez, D
   Woodward, O
   Bryson, K
   Laudes, M
   Lieb, W
   Houtkooper, RH
   Franke, A
   Temmerman, L
   Bjedov, I
   Cocheme, HM
   Kaleta, C
   Cabreiro, F
AF Pryor, Rosina
   Norvaisas, Povilas
   Marinos, Georgios
   Best, Lena
   Thingholm, Louise B.
   Quintaneiro, Leonor M.
   De Haes, Wouter
   Esser, Daniela
   Waschina, Silvio
   Lujan, Celia
   Smith, Reuben L.
   Scott, Timothy A.
   Martinez-Martinez, Daniel
   Woodward, Orla
   Bryson, Kevin
   Laudes, Matthias
   Lieb, Wolfgang
   Houtkooper, Riekelt H.
   Franke, Andre
   Temmerman, Liesbet
   Bjedov, Ivana
   Cocheme, Helena M.
   Kaleta, Christoph
   Cabreiro, Filipe
TI Host-Microbe-Drug-Nutrient Screen Identifies Bacterial Effectors of
   Metformin Therapy
SO CELL
LA English
DT Article
ID HUMAN GUT MICROBIOME; C. ELEGANS; LIFE-SPAN; METABOLISM; EXPRESSION;
   COORDINATION; ALTERS; IMPACT
AB Metformin is the first-line therapy for treating type 2 diabetes and a promising anti-aging drug. We set out to address the fundamental question of how gut microbes and nutrition, key regulators of host physiology, affect the effects of metformin. Combining two tractable genetic models, the bacterium E. coli and the nematode C. elegans, we developed a high-throughput four-way screen to define the underlying host-microbe-drug-nutrient interactions. We show that microbes integrate cues from metformin and the diet through the phosphotransferase signaling pathway that converges on the transcriptional regulator Crp. A detailed experimental characterization of metformin effects downstream of Crp in combination with metabolic modeling of the microbiota in metformin-treated type 2 diabetic patients predicts the production of microbial agmatine, a regulator of metformin effects on host lipid metabolism and lifespan. Our high-throughput screening platform paves the way for identifying exploitable drug-nutrient-microbiome interactions to improve host health and longevity through targeted microbiome therapies.
C1 [Pryor, Rosina; Quintaneiro, Leonor M.; Martinez-Martinez, Daniel; Cocheme, Helena M.; Cabreiro, Filipe] MRC London Inst Med Sci, Du Cane Rd, London W12 0NN, England.
   [Pryor, Rosina; Quintaneiro, Leonor M.; Martinez-Martinez, Daniel; Cocheme, Helena M.; Cabreiro, Filipe] Imperial Coll London, Inst Clin Sci, Hammersmith Hosp Campus,Du Cane Rd, London W12 0NN, England.
   [Pryor, Rosina; Norvaisas, Povilas; Quintaneiro, Leonor M.; Scott, Timothy A.; Woodward, Orla; Cabreiro, Filipe] Univ Coll London & Birkbeck, Inst Struct & Mol Biol, London WC1E 6BT, England.
   [Marinos, Georgios; Best, Lena; Esser, Daniela; Waschina, Silvio; Kaleta, Christoph] Univ Kiel, Inst Expt Med, D-24105 Kiel, Germany.
   [Thingholm, Louise B.; Franke, Andre] Christian Albrechts Univ Kiel, Inst Clin Mol Biol, D-24105 Kiel, Germany.
   [De Haes, Wouter; Temmerman, Liesbet] Katholieke Univ Leuven, Dept Biol, Mol & Funct Neurobiol, B-3000 Leuven, Belgium.
   [Lujan, Celia; Bjedov, Ivana] UCL, UCL Canc Inst, London WC1E 6JD, England.
   [Smith, Reuben L.; Houtkooper, Riekelt H.] Univ Amsterdam, Amsterdam UMC, Lab Genet Metab Dis, NL-1105 AZ Amsterdam, Netherlands.
   [Bryson, Kevin] UCL, Dept Comp Sci, London WC1E 6BT, England.
   [Laudes, Matthias] Univ Hosp Schleswig Holstein, Dept Internal Med 1, Campus Kiel, Kiel, Germany.
   [Lieb, Wolfgang] Christian Albrechts Univ Kiel, Inst Epidemiol, D-24105 Kiel, Germany.
C3 Imperial College London; University of London; Birkbeck University
   London; University College London; University of Kiel; University of
   Kiel; KU Leuven; University of London; University College London;
   University of Amsterdam; University of London; University College
   London; University of Kiel; Schleswig Holstein University Hospital;
   University of Kiel
RP Cabreiro, F (通讯作者)，MRC London Inst Med Sci, Du Cane Rd, London W12 0NN, England.; Cabreiro, F (通讯作者)，Imperial Coll London, Inst Clin Sci, Hammersmith Hosp Campus,Du Cane Rd, London W12 0NN, England.; Cabreiro, F (通讯作者)，Univ Coll London & Birkbeck, Inst Struct & Mol Biol, London WC1E 6BT, England.; Kaleta, C (通讯作者)，Univ Kiel, Inst Expt Med, D-24105 Kiel, Germany.
EM c.kaleta@iem.uni-kiel.de; f.cabreiro@lms.mrc.ac.uk
RI Waschina, Silvio/AAE-2908-2021; Lieb, Wolfgang/AAC-7650-2022; Esser,
   Daniela/ABB-9383-2020; Franke, Andre/B-2151-2010; Bryson,
   Kevin/AAZ-8177-2020; Houtkooper, Riekelt/P-5001-2019
OI Waschina, Silvio/0000-0002-6290-3593; Franke, Andre/0000-0003-1530-5811;
   Bryson, Kevin/0000-0002-1163-6368; Bjedov, Ivana/0000-0001-5894-6016;
   Martinez-Martinez, Daniel/0000-0001-8468-1357; Scott,
   Timothy/0000-0001-7042-8609; Cocheme, Helena/0000-0001-8637-0042; Best,
   Lena/0000-0003-2772-153X; Houtkooper, Riekelt/0000-0001-9961-0842;
   Norvaisas, Povilas/0000-0003-4790-9820; MARINOS,
   GEORGIOS/0000-0002-6443-7696; Temmerman, Liesbet/0000-0002-1249-3995
FU Wellcome Trust/Royal Society [102531/Z/13/Z, 102531/Z/13/A]; German
   Research Foundation [CRC 1182, EXC306]; MRC [MC-A654-5QB90];
   FWOFlanders; ERC [StG 311331, PoC 842174]; MRC [MC_UP_1605/6,
   MC_UP_1102/10] Funding Source: UKRI
FX Worm strains were provided by the Caenorhabditis Genetics Center. F.C.
   acknowledges funding from the Wellcome Trust/Royal Society
   (102531/Z/13/Z and 102531/Z/13/A), C.K. from the German Research
   Foundation (CRC 1182 "Metaorganisms,'' Excellence Cluster "Inflammation
   at Interfaces [EXC306]), H.M.C. from the MRC (MC-A654-5QB90), W.D.H. and
   L.T. from FWOFlanders, and I.B. from ERC StG 311331 and ERC PoC 842174.
   Wethank Clara Essmann, Johannes Zimmermann, Ruwen Bohm, and Guido Laucke
   for technical advice; Kit-Yi Leung and Nicholas Greene for sharing
   unpublished data; Athanasios Typas, Jurg Bahler, and Irene Miguel-Aliaga
   for critical reading of the manuscript; and Andrew Osborne for editing
   the manuscript.
CR Ackerman D, 2012, PLOS GENET, V8, DOI 10.1371/journal.pgen.1002498
   Barzilai N, 2016, CELL METAB, V23, P1060, DOI 10.1016/j.cmet.2016.05.011
   Bauer PV, 2018, CELL METAB, V27, P101, DOI 10.1016/j.cmet.2017.09.019
   Brandstetter BR, 1999, ANN NUTR METAB, V43, P246, DOI 10.1159/000012791
   Burkewitz K, 2015, CELL, V160, P842, DOI 10.1016/j.cell.2015.02.004
   Cabreiro F, 2013, CELL, V153, P228, DOI 10.1016/j.cell.2013.02.035
   Chubukov V, 2014, NAT REV MICROBIOL, V12, P327, DOI 10.1038/nrmicro3238
   Cohn JS, 2010, NUTRIENTS, V2, P116, DOI 10.3390/nu2020116
   Datsenko KA, 2000, P NATL ACAD SCI USA, V97, P6640, DOI 10.1073/pnas.120163297
   David LA, 2014, NATURE, V505, P559, DOI 10.1038/nature12820
   De Haes W, 2014, P NATL ACAD SCI USA, V111, pE2501, DOI 10.1073/pnas.1321776111
   DeCorby A, 2007, BBA-BIOENERGETICS, V1767, P1157, DOI 10.1016/j.bbabio.2007.07.003
   Elmadfa I., 2015, ERNAHRUNG MENSCHEN
   Fischbach MA, 2018, CELL, V174, P785, DOI 10.1016/j.cell.2018.07.038
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Gao AW, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-02539-w
   Garcia-Gonzalez AP, 2017, CELL, V169, P431, DOI 10.1016/j.cell.2017.03.046
   Gelius-Dietrich G, 2013, BMC SYST BIOL, V7, DOI 10.1186/1752-0509-7-125
   Gonzalez PS, 2018, NATURE, V563, P719, DOI 10.1038/s41586-018-0729-3
   Graspeuntner S, 2019, CLIN INFECT DIS, V69, P268, DOI 10.1093/cid/ciy882
   Hilbert ZA, 2018, ELIFE, V7, DOI [10.7554/eLife.36547, 10.7554/elife.36547]
   Ho CL, 2018, NAT BIOMED ENG, V2, P27, DOI 10.1038/s41551-017-0181-y
   Hussey R, 2017, PLOS GENET, V13, DOI 10.1371/journal.pgen.1006806
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kiela PR, 2016, BEST PRACT RES CL GA, V30, P145, DOI 10.1016/j.bpg.2016.02.007
   Kim D, 2015, NAT METHODS, V12, P357, DOI [10.1038/NMETH.3317, 10.1038/nmeth.3317]
   Kim HE, 2016, CELL, V166, P1539, DOI 10.1016/j.cell.2016.08.027
   Krawczak M, 2006, COMMUNITY GENET, V9, P55, DOI 10.1159/000090694
   Kundu P, 2017, CELL, V171, P1481, DOI 10.1016/j.cell.2017.11.024
   Le Chatelier E, 2013, NATURE, V500, P541, DOI 10.1038/nature12506
   Lee SJ, 2009, CELL METAB, V10, P379, DOI 10.1016/j.cmet.2009.10.003
   Li H, 2009, BIOINFORMATICS, V25, P1754, DOI 10.1093/bioinformatics/btp324
   Lloyd-Price J, 2017, NATURE, V550, P61, DOI 10.1038/nature23889
   Love MI, 2014, GENOME BIOL, V15, DOI 10.1186/s13059-014-0550-8
   Ma DK, 2012, NEURON, V73, P925, DOI 10.1016/j.neuron.2011.12.037
   Magnusdottir S, 2017, NAT BIOTECHNOL, V35, P81, DOI 10.1038/nbt.3703
   Maier L, 2018, NATURE, V555, P623, DOI 10.1038/nature25979
   Muller N, 2015, J LIPID RES, V56, P1034, DOI 10.1194/jlr.P052209
   Onken B, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0008758
   Piper MDW, 2014, NAT METHODS, V11, P100, DOI [10.1038/nmeth.2731, 10.1038/NMETH.2731]
   Pryor R, 2015, BIOCHEM J, V471, P307, DOI 10.1042/BJ20150497
   Puchalska P, 2017, CELL METAB, V25, P262, DOI 10.1016/j.cmet.2016.12.022
   Qi B, 2018, CELL, V175, P571, DOI 10.1016/j.cell.2018.07.032
   Robinson MD, 2010, BIOINFORMATICS, V26, P139, DOI 10.1093/bioinformatics/btp616
   Rothschild D, 2018, NATURE, V555, P210, DOI 10.1038/nature25973
   SATISHCHANDRAN C, 1986, J BACTERIOL, V165, P843, DOI 10.1128/jb.165.3.843-848.1986
   Schmidt TSB, 2018, CELL, V172, P1198, DOI 10.1016/j.cell.2018.02.044
   Schmieder R, 2011, BIOINFORMATICS, V27, P863, DOI 10.1093/bioinformatics/btr026
   Scott TA, 2017, CELL, V169, P442, DOI 10.1016/j.cell.2017.03.040
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Slack C, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0047699
   Sundin OH, 2017, BMC MICROBIOL, V17, DOI 10.1186/s12866-017-1059-6
   Weir HJ, 2017, CELL METAB, V26, P884, DOI 10.1016/j.cmet.2017.09.024
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Wu LF, 2016, CELL, V167, P1705, DOI 10.1016/j.cell.2016.11.055
   You CH, 2013, NATURE, V500, P301, DOI 10.1038/nature12446
   Zhang F, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.00485
   Zimmermann J., 2019, BIORXIV, DOI [10.1101/554345, DOI 10.1101/554345]
NR 58
TC 129
Z9 136
U1 6
U2 67
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
SN 0092-8674
EI 1097-4172
J9 CELL
JI Cell
PD SEP 5
PY 2019
VL 178
IS 6
BP 1299
EP +
DI 10.1016/j.cell.2019.08.003
PG 43
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA IV0QF
UT WOS:000483983000008
PM 31474368
OA Green Published, Green Accepted, hybrid
DA 2023-06-08
ER

PT J
AU Ke, HR
   Li, F
   Deng, WL
   Li, ZT
   Wang, SQ
   Lv, PJ
   Chen, Y
AF Ke, Haoran
   Li, Fang
   Deng, Wenlin
   Li, Zitong
   Wang, Siqi
   Lv, Pinjing
   Chen, Ye
TI Metformin Exerts Anti-inflammatory and Mucus Barrier Protective Effects
   by Enriching Akkermansia muciniphila in Mice With Ulcerative Colitis
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE intestinal barrier; inflammatory bowel diseases; probiotics; gut
   microbiota; mucin2
ID INFLAMMATORY-BOWEL-DISEASE; GUT MICROBIOTA; INTESTINAL INFLAMMATION;
   CROHNS-DISEASE; GERM-FREE; MUCIN; BACTERIA; DIFFERENTIATION; PROBIOTICS;
   THERAPY
AB The present study aimed to determine if metformin exerts anti-inflammatory and mucus-protective effects via the gut microbiota. Metformin has extensive benefits including anti-inflammatory effects. Previous studies showed that metformin changed the gut microbiota composition and increases the number of goblet cells. Intestinal dysbiosis and goblet cell depletion are important features of ulcerative colitis (UC). The underlying mechanism and whether metformin can improve the mucus barrier in UC remain unclear. Metformin (400 mg/kg/day) was administered to mice with dextran sulfate sodium (DSS)-induced UC for 2 wk to investigate the effects of metformin on the intestinal mucus barrier. The gut microbiota was depleted, using antibiotics, to explore its role in the mucus-protecting effects of metformin. Akkermansia muciniphila (A. muciniphila), which was enriched in metformin-treated mice, was administered to mice to investigate the effects of the bacteria on UC and the mucus barrier. Metformin attenuated DSS-induced UC in mice, as evidenced by the alleviation of diarrhea, hematochezia, and the decrease in body weight. The expression of mucin2, a prominent mucus barrier protein, was increased in the metformin-treated group compared to the DSS-treated group. Furthermore, fecal 16S rRNA analysis showed that metformin treatment changed the gut microbiota composition by increasing the relative abundance of Lactobacillus and Akkermansia species while decreasing Erysipelatoclostridium at the genus level. Antibiotic treatment partly abolished the anti-inflammatory and mucus-protecting effects of metformin. Administration of A. muciniphila alleviated the colonic inflammation and mucus barrier disruption. Metformin alleviated DSS-induced UC in mice and protected against cell damage via affecting the gut microbiota, thereby providing a new mechanism for the therapeutic effect of metformin in patients with UC. This study also provides evidence that A. muciniphila as a probiotic has potential benefits for UC.
C1 [Ke, Haoran; Li, Fang; Deng, Wenlin; Li, Zitong; Wang, Siqi; Lv, Pinjing; Chen, Ye] Southern Med Univ, Dept Gastroenterol, State Key Lab Organ Failure Res, Guangdong Prov Key Lab Gastroenterol,Nanfang Hosp, Guangzhou, Peoples R China.
   [Li, Fang] Hainan Gen Hosp, Haikou, Hainan, Peoples R China.
   [Deng, Wenlin] Sun Yat Sen Univ, Affiliated Hosp 6, Dept Pediat, Guangzhou, Peoples R China.
C3 Southern Medical University - China; Sun Yat Sen University
RP Chen, Y (通讯作者)，Southern Med Univ, Dept Gastroenterol, State Key Lab Organ Failure Res, Guangdong Prov Key Lab Gastroenterol,Nanfang Hosp, Guangzhou, Peoples R China.
EM yechen@smu.edu.cn
FU National Natural Science Foundation of China [81770529]; National ST
   Megaprojects [2020ZX09201017]; Guangdong gastrointestinal disease
   research center [2017B030314037]
FX This project is supported by the National Natural Science Foundation of
   China (No. 81770529); National S&T Megaprojects (2020ZX09201017);
   Guangdong gastrointestinal disease research center (No. 2017B020209003);
   and Guangdong gastrointestinal disease research center (No.
   2017B030314037).
CR Algieri F, 2021, EUR J NUTR, V60, P2537, DOI 10.1007/s00394-020-02441-8
   Anisimov VN, 2013, CELL CYCLE, V12, P3483, DOI 10.4161/cc.26928
   Bailey CJ, 2008, DIABETOLOGIA, V51, P1552, DOI 10.1007/s00125-008-1053-5
   Bauer PV, 2018, CELL METAB, V27, P101, DOI 10.1016/j.cmet.2017.09.019
   Becker S, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0055620
   Bergstrom Anders, 2012, BMC Res Notes, V5, P402, DOI 10.1186/1756-0500-5-402
   Birchenough GMH, 2016, SCIENCE, V352, P1535, DOI 10.1126/science.aaf7419
   Cameron AR, 2016, CIRC RES, V119, P652, DOI 10.1161/CIRCRESAHA.116.308445
   Chassaing Benoit, 2014, Curr Protoc Immunol, V104, DOI 10.1002/0471142735.im1525s104
   Chen X, 2020, GUT, V69, P513, DOI 10.1136/gutjnl-2019-319101
   Deng J, 2018, J CELL MOL MED, V22, P546, DOI 10.1111/jcmm.13342
   Derrien M, 2004, INT J SYST EVOL MICR, V54, P1469, DOI 10.1099/ijs.0.02873-0
   Dhar P, 2019, FRONT CELL INFECT MI, V9, DOI 10.3389/fcimb.2019.00117
   Di Fusco D, 2018, CLIN SCI, V132, P1155, DOI 10.1042/CS20180167
   Earley H, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-51878-3
   Frank DN, 2007, P NATL ACAD SCI USA, V104, P13780, DOI 10.1073/pnas.0706625104
   Gancarcikova S, 2020, CELLS-BASEL, V9, DOI 10.3390/cells9122571
   Gersemann M, 2009, DIFFERENTIATION, V77, P84, DOI 10.1016/j.diff.2008.09.008
   Gregorieff A, 2009, GASTROENTEROLOGY, V137, P1333, DOI 10.1053/j.gastro.2009.06.044
   Heazlewood CK, 2008, PLOS MED, V5, P440, DOI 10.1371/journal.pmed.0050054
   Hernandez-Chirlaque C, 2016, J CROHNS COLITIS, V10, P1324, DOI 10.1093/ecco-jcc/jjw096
   Hudcovic T, 2001, FOLIA MICROBIOL, V46, P565, DOI 10.1007/BF02818004
   Hur KY, 2015, J DIABETES INVEST, V6, P600, DOI 10.1111/jdi.12328
   Jakobsson HE, 2015, EMBO REP, V16, P164, DOI 10.15252/embr.201439263
   Janda JM, 2007, J CLIN MICROBIOL, V45, P2761, DOI 10.1128/JCM.01228-07
   Johansson MEV, 2014, GUT, V63, P281, DOI 10.1136/gutjnl-2012-303207
   Johansson MEV, 2011, SCIENCE, V334, P182, DOI 10.1126/science.1213909
   Kennedy EA, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.01534
   Kim WK, 2019, J FUNCT FOODS, V52, P565, DOI 10.1016/j.jff.2018.11.035
   Knox Natalie C, 2019, Curr Treat Options Gastroenterol, V17, P115, DOI 10.1007/s11938-019-00221-w
   Koh SJ, 2014, J GASTROEN HEPATOL, V29, P502, DOI 10.1111/jgh.12435
   Kuhn F, 2015, VISZERALMEDIZIN, V31, P246, DOI 10.1159/000438894
   Lee SY, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0135858
   Leone A, 2014, CANCER TREAT RES, V159, P355, DOI 10.1007/978-3-642-38007-5_21
   Linden SK, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003952
   M'Koma AE, 2013, CLIN MED INSIGHTS-GA, V6, P33, DOI 10.4137/CGast.S12731
   Mariat D, 2009, BMC MICROBIOL, V9, DOI 10.1186/1471-2180-9-123
   McCreight LJ, 2016, DIABETOLOGIA, V59, P426, DOI 10.1007/s00125-015-3844-9
   Nair Anroop B, 2016, J Basic Clin Pharm, V7, P27, DOI 10.4103/0976-0105.177703
   Nishida A, 2012, GASTROENTEROLOGY, V142, P865, DOI 10.1053/j.gastro.2011.12.036
   Pan Q, 2013, J BIOL CHEM, V288, P5407, DOI 10.1074/jbc.M112.408245
   Paone P, 2020, GUT, V69, P2232, DOI 10.1136/gutjnl-2020-322260
   Paramsothy S, 2017, LANCET, V389, P1218, DOI 10.1016/S0140-6736(17)30182-4
   Petersson J, 2011, AM J PHYSIOL-GASTR L, V300, pG327, DOI 10.1152/ajpgi.00422.2010
   Png CW, 2010, AM J GASTROENTEROL, V105, P2420, DOI 10.1038/ajg.2010.281
   Rajilic-Stojanovic M, 2013, INFLAMM BOWEL DIS, V19, P481, DOI 10.1097/MIB.0b013e31827fec6d
   Rena G, 2018, CIRCULATION, V137, P422, DOI 10.1161/CIRCULATIONAHA.117.031735
   Rio Donald C, 2010, Cold Spring Harb Protoc, V2010, DOI 10.1101/pdb.prot5439
   Robertson D, 2008, BMC CELL BIOL, V9, DOI 10.1186/1471-2121-9-13
   Rodriguez-Nogales A, 2018, FRONT PHARMACOL, V9, DOI 10.3389/fphar.2018.00468
   Saisho Y, 2015, ENDOCR METAB IMMUNE, V15, P196, DOI 10.2174/1871530315666150316124019
   Santoru ML, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-10034-5
   Scarpello JHB, 2008, DIABETES VASC DIS RE, V5, P157, DOI 10.3132/dvdr.2008.027
   Schroeder BO, 2019, GASTROENTEROL REP, V7, P3, DOI 10.1093/gastro/goy052
   Shao YK, 2017, OBES SURG, V27, P295, DOI 10.1007/s11695-016-2297-7
   Shen J, 2014, INFLAMM BOWEL DIS, V20, P21, DOI 10.1097/01.MIB.0000437495.30052.be
   Shen ZH, 2018, WORLD J GASTROENTERO, V24, P5, DOI 10.3748/wjg.v24.i1.5
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Solomon L, 2010, COMP CLIN PATHOLOGY, V19, P235, DOI DOI 10.1007/S00580-010-0979-4
   Song CH, 2018, GUT LIVER, V12, P682, DOI 10.5009/gnl18221
   Strugala V, 2008, INT J CLIN PRACT, V62, P762, DOI 10.1111/j.1742-1241.2007.01665.x
   Swidsinski A, 2007, GUT, V56, P343, DOI 10.1136/gut.2006.098160
   Tan HZ, 2019, FOOD RES INT, V116, P637, DOI 10.1016/j.foodres.2018.08.088
   Testa A, 2017, PATIENT PREFER ADHER, V11, P297, DOI 10.2147/PPA.S127039
   Troll JV, 2018, DEVELOPMENT, V145, DOI 10.1242/dev.155317
   Ungaro R, 2017, LANCET, V389, P1756, DOI 10.1016/S0140-6736(16)32126-2
   van der Flier LG, 2009, ANNU REV PHYSIOL, V71, P241, DOI 10.1146/annurev.physiol.010908.163145
   van der Post S, 2019, GUT, V68, P2142, DOI 10.1136/gutjnl-2018-317571
   Van der Sluis M, 2006, GASTROENTEROLOGY, V131, P117, DOI 10.1053/j.gastro.2006.04.020
   van Putten JPM, 2017, J INNATE IMMUN, V9, P281, DOI 10.1159/000453594
   Vila AV, 2018, SCI TRANSL MED, V10, DOI 10.1126/scitranslmed.aap8914
   Walker AW, 2011, BMC MICROBIOL, V11, DOI 10.1186/1471-2180-11-7
   Wang ZQ, 2015, INFLAMM BOWEL DIS, V21, P1894, DOI 10.1097/MIB.0000000000000421
   Xue YS, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0168670
   Yeo S, 2020, MICROORGANISMS, V8, DOI 10.3390/microorganisms8060845
   Yin J, 2015, J AM HEART ASSOC, V4, DOI 10.1161/JAHA.115.002699
   Zhai R, 2019, FRONT CELL INFECT MI, V9, DOI 10.3389/fcimb.2019.00239
   Zhang M., 2019, GASTROENTEROLOGY, V156, pS, DOI [10.1016/S0016-5085(19)39838-5, DOI 10.1016/S0016-5085(19)39838-5]
   Zhang YZ, 2014, WORLD J GASTROENTERO, V20, P91, DOI 10.3748/wjg.v20.i1.91
   Zhou YL, 2018, MSYSTEMS, V3, DOI 10.1128/mSystems.00188-17
NR 80
TC 18
Z9 18
U1 4
U2 30
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD SEP 30
PY 2021
VL 12
AR 726707
DI 10.3389/fphar.2021.726707
PG 17
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA WH4JQ
UT WOS:000707646600001
PM 34658866
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Wu, HR
   Wang, XM
   Fang, XY
   Lian, FM
   Li, M
   Liao, JQ
   Dai, D
   Tian, JX
AF Wu, Haoran
   Wang, Xinmiao
   Fang, Xinyi
   Lian, Fengmei
   Li, Min
   Liao, Jiangquan
   Dai, Dan
   Tian, Jiaxing
TI Metformin modulates the gut microbiome in a mice model of high-fat
   diet-induced glycolipid metabolism disorder
SO BMJ OPEN DIABETES RESEARCH & CARE
LA English
DT Article
DE Metformin; Diabetes Mellitus; Experimental; Hyperlipidemias;
   Microbiology
ID AKKERMANSIA-MUCINIPHILA; RNA-SEQ; HOMEOSTASIS; GENOMES
AB IntroductionMetformin (MET) can regulate glucose and lipid levels, and the gut microbiota may be involved in the control of metabolism. We hypothesized that MET alleviates glucolipid metabolism disorder by modulating gut microbiota and microbial metabolites.Research design and methodsA total of 24 male C57BL/6 J mice were equally divided into three groups (normal control, model control (MC), and MET-treated groups). Model mice were established by feeding a high-fat diet for 6 weeks. The MET-treated group was administered MET solution (2.5 g/100 mL, 250 mg/kg). Fecal samples were collected to characterize the microbiota system using metagenomic shotgun sequencing and gas chromatography-time of flight-mass spectrometry analysis. Phenotypic and biochemical indices were obtained for further correlation analysis.ResultsCompared with the MC group, MET reduced the levels of weight, glucose, areas under the glucose curve in the glucose tolerance test, triglyceride (TG), and total cholesterol (TC). A decreasing abundance of bacteria, including Parabacteroides distasonis, and an increasing abundance of bacteria, including Bacteroides vulgatus, were observed in the MET-treated group. The 2-deoxytetronic acid declined after MET intervention and was positively correlated with species over-represented in the MC group and negatively correlated with species enriched in the MET-treated group. Additionally, species enriched in the MET-treated group negatively correlated with glucose, areas under the glucose curve in the glucose tolerance test, and TGs. Further, the correlation between the differential metabolites, which decreased after MET intervention, and the phenotypic indices was positive.ConclusionsMET-induced restoration of intestinal homeostasis correlates with the amelioration of host glucolipid metabolism.
C1 [Wu, Haoran; Fang, Xinyi; Li, Min; Tian, Jiaxing] China Acad Chinese Med Sci, Inst Metab Dis, Guanganmen Hosp, Beijing, Peoples R China.
   [Wu, Haoran; Fang, Xinyi] Beijing Univ Chinese Med, Grad Sch, Beijing, Peoples R China.
   [Wang, Xinmiao; Lian, Fengmei; Dai, Dan] China Acad Chinese Med Sci, Guanganmen Hosp, Beijing, Peoples R China.
   [Liao, Jiangquan] China Japan Friendship Hosp, Ctr Cardiovasc Dis, Dept Natl Integrated Tradit & Western Med, Beijing, Peoples R China.
C3 China Academy of Chinese Medical Sciences; Guang'anmen Hospital, CACMS;
   Beijing University of Chinese Medicine; China Academy of Chinese Medical
   Sciences; Guang'anmen Hospital, CACMS; China-Japan Friendship Hospital
RP Tian, JX (通讯作者)，China Acad Chinese Med Sci, Inst Metab Dis, Guanganmen Hosp, Beijing, Peoples R China.
EM tina_yai@126.com
OI Wu, Haoran/0000-0003-2906-510X
FU National Natural Science Foundation of China [81904187, 81803923];
   Capital Health Research and Development of Special Fund [CD2020-4-4155];
   CACMS Scientific and Technological Innovation Fund [CI2021A01601]; Open
   Project of National Facility for Translational Medicine (Shanghai)
   [TMSK-2021-407]; Innovation Team and Talents Cultivation Program of
   National Administration of Traditional Chinese Medicine
   [ZYYCXTD-D-202001]; Outstanding Young Scientific and Technological
   Talents Program [ZZ13-YQ-026]
FX This work was supported by the National Natural Science Foundation of
   China (numbers 81904187 and 81803923), Capital Health Research and
   Development of Special Fund (CD2020-4-4155), CACMS Scientific and
   Technological Innovation Fund (CI2021A01601), Open Project of National
   Facility for Translational Medicine (Shanghai, TMSK-2021-407),
   Innovation Team and Talents Cultivation Program of National
   Administration of Traditional Chinese Medicine (number ZYYCXTD-D-202001)
   and the Outstanding Young Scientific and Technological Talents Program
   (ZZ13-YQ-026). The design, management, analysis and reporting of the
   study are entirely independent of the aforementioned programmes.
CR Amer Diabet Assoc, 2020, DIABETES CARE, V43, pS111, DOI [10.2337/dc20-s010, 10.2337/dc20-S010]
   An DD, 2014, CELL, V156, P123, DOI 10.1016/j.cell.2013.11.042
   Andoh A, 2016, J CLIN BIOCHEM NUTR, V59, P65, DOI 10.3164/jcbn.15-152
   Chen TT, 2021, GENOM PROTEOM BIOINF, V19, P578, DOI 10.1016/j.gpb.2021.08.001
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Di Lorenzo F, 2020, ACS CENTRAL SCI, V6, P1602, DOI 10.1021/acscentsci.0c00791
   Dray S, 2007, J STAT SOFTW, V22, P1, DOI 10.18637/jss.v022.i04
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Besson JCF, 2018, J PHARM PHARMACOL, V70, P178, DOI 10.1111/jphp.12839
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Hastings J, 2016, NUCLEIC ACIDS RES, V44, pD1214, DOI 10.1093/nar/gkv1031
   Ji LN, 2013, AM J MED, V126, DOI 10.1016/j.amjmed.2013.02.035
   Jia WP, 2019, DIABETES-METAB RES, V35, DOI 10.1002/dmrr.3158
   Kanehisa M, 2008, NUCLEIC ACIDS RES, V36, pD480, DOI 10.1093/nar/gkm882
   Koh A, 2020, CELL METAB, V32, P643, DOI 10.1016/j.cmet.2020.07.012
   Le Chatelier E, 2013, NATURE, V500, P541, DOI 10.1038/nature12506
   Leite AZ, 2017, FRONT IMMUNOL, V8, DOI 10.3389/fimmu.2017.01107
   Li RQ, 2008, BIOINFORMATICS, V24, P713, DOI 10.1093/bioinformatics/btn025
   Li WZ, 2006, BIOINFORMATICS, V22, P1658, DOI 10.1093/bioinformatics/btl158
   Luo RB, 2012, GIGASCIENCE, V1, DOI 10.1186/2047-217X-1-18
   Mach F, 2018, EUR HEART J, V39, P2526, DOI 10.1093/eurheartj/ehy182
   Miller AW, 2019, ISME J, V13, P1379, DOI 10.1038/s41396-019-0357-4
   Nie QX, 2019, FOOD HYDROCOLLOID, V86, P34, DOI 10.1016/j.foodhyd.2017.12.026
   Nielsen HB, 2014, NAT BIOTECHNOL, V32, P822, DOI 10.1038/nbt.2939
   Noble EE, 2021, TRANSL PSYCHIAT, V11, DOI 10.1038/s41398-021-01309-7
   Noguchi H, 2006, NUCLEIC ACIDS RES, V34, P5623, DOI 10.1093/nar/gkl723
   O'Leary NA, 2016, NUCLEIC ACIDS RES, V44, pD733, DOI 10.1093/nar/gkv1189
   Pernicova I, 2020, LANCET DIABETES ENDO, V8, P278, DOI 10.1016/S2213-8587(20)30021-8
   Pryor R, 2019, CELL, V178, P1299, DOI 10.1016/j.cell.2019.08.003
   Qi XY, 2019, NAT MED, V25, P1225, DOI 10.1038/s41591-019-0509-0
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Rotroff DM, 2016, FRONT PHARMACOL, V7, DOI 10.3389/fphar.2016.00135
   Round JL, 2011, SCIENCE, V332, P974, DOI 10.1126/science.1206095
   Schurch NJ, 2016, RNA, V22, P839, DOI 10.1261/rna.053959.115
   Segata N, 2011, GENOME BIOL, V12, DOI 10.1186/gb-2011-12-6-r60
   Stroes ES, 2015, EUR HEART J, V36, P1012, DOI 10.1093/eurheartj/ehv043
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Todd EV, 2016, MOL ECOL, V25, P1224, DOI 10.1111/mec.13526
   Turner RC, 1998, BMJ-BRIT MED J, V316, P823, DOI 10.1136/bmj.316.7134.823
   Wang K, 2019, CELL REP, V26, P222, DOI 10.1016/j.celrep.2018.12.028
   Wang K, 2019, PROBIOTICS ANTIMICRO, V11, P1182, DOI 10.1007/s12602-018-9441-8
   Weng SW, 2020, ENDOCRINE, V67, P305, DOI 10.1007/s12020-020-02190-y
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Xie GX, 2016, ONCOTARGET, V7, P19355, DOI 10.18632/oncotarget.8466
   Xu T, 2015, DIABETES CARE, V38, P1858, DOI 10.2337/dc15-0658
   Xue YB, 2022, NUCLEIC ACIDS RES, V50, pD27, DOI 10.1093/nar/gkab951
   Yan XF, 2020, CIRC RES, V126, P839, DOI 10.1161/CIRCRESAHA.119.316394
   Yang KL, 2021, GASTROENTEROLOGY, V161, P1257, DOI 10.1053/j.gastro.2021.06.056
   Yoshida N, 2018, CIRCULATION, V138, P2486, DOI 10.1161/CIRCULATIONAHA.118.033714
NR 49
TC 2
Z9 2
U1 7
U2 7
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
EI 2052-4897
J9 BMJ OPEN DIAB RES CA
JI BMJ Open Diab. Res. Care
PD DEC
PY 2022
VL 10
IS 6
AR e003149
DI 10.1136/bmjdrc-2022-003149
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 7A3RW
UT WOS:000898378800003
PM 36593662
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Su, CY
   Li, XX
   Yang, YX
   Du, Y
   Zhang, XM
   Wang, L
   Hong, B
AF Su, Chunyan
   Li, Xingxing
   Yang, Yuxin
   Du, Yu
   Zhang, Xiumin
   Wang, Li
   Hong, Bin
TI Metformin alleviates choline diet-induced TMAO elevation in C57BL/6J
   mice by influencing gut-microbiota composition and functionality
SO NUTRITION & DIABETES
LA English
DT Article
ID TRIMETHYLAMINE-N-OXIDE; LACTOBACILLUS-ACIDOPHILUS; INTESTINAL
   MICROBIOTA; ATHEROSCLEROSIS; INHIBITION; METABOLISM; ALTERS
AB Trimethylamine-N-oxide (TMAO), a gut-microbiota-dependent metabolite generated from its dietary precursors such as choline, has been identified as an independent risk factor for atherosclerosis. Metformin is the most widely used drug for the treatment of type 2 diabetes (T2D), which has therapeutic effects on hyperglycemia accelerated atherosclerosis. A growing body of evidence suggest that metformin plays a therapeutic role by regulating the structure and metabolic function of gut microbiota. However, whether metformin has an impact on gut-microbiota-mediated TMAO production from choline remains obscure. In this study, the oral administration of metformin significantly reduced choline diet-increased serum TMAO in choline diet-fed C57BL/6J mice. The diversity analysis based on 16S rRNA gene sequencing of C57BL/6J mice fecal samples indicated that metformin markedly changed the gut-microbiota composition. Metformin was positively correlated with the enrichment of different intestinal bacteria such as Bifidobacterium and Akkermansia and a lower cutC (a choline utilization gene) abundance. Furthermore, the ex vivo and in vitro inhibitory effects of metformin on choline metabolism of TMA-producing bacteria were confirmed under anaerobic condition. The results suggested that metformin suppresses serum TMAO level by remodeling gut microbiota involved in TMA generation from choline.
C1 [Su, Chunyan; Li, Xingxing; Yang, Yuxin; Du, Yu; Zhang, Xiumin; Wang, Li; Hong, Bin] Chinese Acad Med Sci & Peking Union Med Coll, NHC Key Lab Biotechnol Antibiot, 1 Tiantan Xili, Beijing 100050, Peoples R China.
   [Li, Xingxing; Hong, Bin] Chinese Acad Med Sci & Peking Union Med Coll, Inst Med Biotechnol, CAMS Key Lab Synthet Biol Drug Innovat, 1 Tiantan Xili, Beijing 100050, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College; Chinese Academy of Medical Sciences -
   Peking Union Medical College; Peking Union Medical College
RP Wang, L; Hong, B (通讯作者)，Chinese Acad Med Sci & Peking Union Med Coll, NHC Key Lab Biotechnol Antibiot, 1 Tiantan Xili, Beijing 100050, Peoples R China.; Hong, B (通讯作者)，Chinese Acad Med Sci & Peking Union Med Coll, Inst Med Biotechnol, CAMS Key Lab Synthet Biol Drug Innovat, 1 Tiantan Xili, Beijing 100050, Peoples R China.
EM wangli_imb@163.com; binhong69@hotmail.com
RI Wang, Li/Z-4308-2019
OI Wang, Li/0000-0001-7340-416X; Du, Yu/0000-0002-4901-6746; Hong,
   Bin/0000-0001-6244-8298
FU National Natural Science Foundation of China [81473214, 81621064]; Drug
   Innovation Major Project of China [2018ZX09711001-003-006,
   2018ZX09711001-007-002]; CAMS Innovation Fund for Medical Sciences
   [2016-I2M-2-002, 2016-I2M-1011]
FX This work was supported by grants from the National Natural Science
   Foundation of China 81473214 (to L.W.) and 81621064 (to B.H.); the Drug
   Innovation Major Project of China 2018ZX09711001-003-006 (to L.W.),
   2018ZX09711001-007-002 (to Y.D.); CAMS Innovation Fund for Medical
   Sciences 2016-I2M-2-002 (to L.W.), 2016-I2M-1011 (to B.H.).
CR Bailey CJ, 2008, DIABETOLOGIA, V51, P1552, DOI 10.1007/s00125-008-1053-5
   Bauer PV, 2018, CELL METAB, V27, P101, DOI 10.1016/j.cmet.2017.09.019
   Bennett BJ, 2013, CELL METAB, V17, P49, DOI 10.1016/j.cmet.2012.12.011
   Chen ML, 2016, MBIO, V7, DOI 10.1128/mBio.02210-15
   Craciun S, 2012, P NATL ACAD SCI USA, V109, P21307, DOI 10.1073/pnas.1215689109
   Croyal M, 2020, J CLIN ENDOCR METAB, V105, P2371, DOI 10.1210/clinem/dgaa188
   Depommier C, 2019, NAT MED, V25, P1096, DOI 10.1038/s41591-019-0495-2
   Forouzandeh F, 2014, J AM HEART ASSOC, V3, DOI 10.1161/JAHA.114.001202
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Huang Y, 2014, APPL ENVIRON MICROB, V80, P7496, DOI 10.1128/AEM.02926-14
   Jenkins AJ, 2018, CURR OPIN LIPIDOL, V29, P346, DOI 10.1097/MOL.0000000000000532
   Ke YL, 2018, FREE RADICAL BIO MED, V116, P88, DOI 10.1016/j.freeradbiomed.2018.01.007
   Koeth RA, 2013, NAT MED, V19, P576, DOI 10.1038/nm.3145
   Lagkouvardos I, 2019, MICROBIOME, V7, DOI 10.1186/s40168-019-0637-2
   Orman M, 2019, J AM CHEM SOC, V141, P33, DOI 10.1021/jacs.8b04883
   Pascale A, 2019, CURR OPIN PHARMACOL, V49, P1, DOI 10.1016/j.coph.2019.03.011
   Pryor R, 2019, CELL, V178, P1299, DOI 10.1016/j.cell.2019.08.003
   Roberts AB, 2018, NAT MED, V24, P1407, DOI 10.1038/s41591-018-0128-1
   Romano KA, 2015, MBIO, V6, DOI 10.1128/mBio.02481-14
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Tang WHW, 2017, CIRC RES, V120, P1183, DOI 10.1161/CIRCRESAHA.117.309715
   Wang ZN, 2015, CELL, V163, P1585, DOI 10.1016/j.cell.2015.11.055
   Wang ZN, 2011, NATURE, V472, P57, DOI 10.1038/nature09922
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Yadav H, 2007, NUTRITION, V23, P62, DOI 10.1016/j.nut.2006.09.002
NR 25
TC 5
Z9 5
U1 2
U2 16
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 2044-4052
J9 NUTR DIABETES
JI Nutr. Diabetes
PD JUL 31
PY 2021
VL 11
IS 1
AR 27
DI 10.1038/s41387-021-00169-w
PG 6
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA UC6LG
UT WOS:000686634800001
PM 34389700
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU He, L
AF He, Ling
TI Metformin and Systemic Metabolism
SO TRENDS IN PHARMACOLOGICAL SCIENCES
LA English
DT Review
ID ACTIVATED PROTEIN-KINASE; ORGANIC CATION TRANSPORTERS; GLUCAGON-LIKE
   PEPTIDE-1; HEPATIC GLUCONEOGENESIS; GLUCOSE-PRODUCTION; ADIPOSE-TISSUE;
   SKELETAL-MUSCLE; AMINO-ACIDS; INSULIN; AMPK
AB Metformin can improve patients' hyperglycemia through significant suppression of hepatic glucose production. However, up to 300 times higher concentrations of metformin accumulate in the intestine than in the circulation, where it alters nutrient metabolism in intestinal epithelial cells and microbiome, leading to increased lactate production. Hepatocytes use lactate to make glucose at the cost of energy expenditure, creating a futile intestine-liver cycle. Furthermore, metformin reduces blood lipopolysaccharides and its initiated low-grade inflammation and increased oxidative phosphorylation in liver and adipose tissues. These metformin effects result in the improvement of insulin sensitivity and glucose utilization in extrahepatic tissues. In this review, I discuss the current understanding of the impact of metformin on systemic metabolism and its molecular mechanisms of action in various tissues.
C1 [He, Ling] Johns Hopkins Univ, Sch Med, Dept Pediat, Baltimore, MD 21287 USA.
   [He, Ling] Johns Hopkins Univ, Sch Med, Dept Pharmacol & Mol Sci, Baltimore, MD 21287 USA.
C3 Johns Hopkins University; Johns Hopkins University
RP He, L (通讯作者)，Johns Hopkins Univ, Sch Med, Dept Pediat, Baltimore, MD 21287 USA.; He, L (通讯作者)，Johns Hopkins Univ, Sch Med, Dept Pharmacol & Mol Sci, Baltimore, MD 21287 USA.
EM heling@jhmi.edu
FU National Institute of Diabetes and Digestive and Kidney Diseases
   [R01DK107641, R01DK120309]
FX This work was supported in part by grants from the National Institute of
   Diabetes and Digestive and Kidney Diseases: R01DK107641 and R01DK120309.
   I thank Timothy Phelps for helping with figure animations.
CR Alshawi A, 2019, J BIOL CHEM, V294, P2839, DOI 10.1074/jbc.RA118.006670
   An HY, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-67030-5
   Bailey CJ, 2008, DIABETOLOGIA, V51, P1552, DOI 10.1007/s00125-008-1053-5
   BAILEY CJ, 1994, BRIT J PHARMACOL, V112, P671, DOI 10.1111/j.1476-5381.1994.tb13128.x
   Bannister CA, 2014, DIABETES OBES METAB, V16, P1165, DOI 10.1111/dom.12354
   Bridges HR, 2014, BIOCHEM J, V462, P475, DOI 10.1042/BJ20140620
   Cabreiro F, 2013, CELL, V153, P228, DOI 10.1016/j.cell.2013.02.035
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   Cao J, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-00163-w
   Cao J, 2014, J BIOL CHEM, V289, P20435, DOI 10.1074/jbc.M114.567271
   Chen EC, 2015, MOL PHARMACOL, V88, P75, DOI 10.1124/mol.114.096776
   Chen Y, 2009, PHARMACOGENOMICS J, V9, P127, DOI 10.1038/tpj.2008.19
   Choi MK, 2007, BIOPHARM DRUG DISPOS, V28, P501, DOI 10.1002/bdd.576
   Coll AP, 2020, NATURE, V578, P444, DOI 10.1038/s41586-019-1911-y
   Dickens F, 1939, BIOCHEM J, V33, P2017, DOI 10.1042/bj0332017
   Duan Y, 2013, NEURAL REGEN RES, V8, P2379, DOI 10.3969/j.issn.1673-5374.2013.25.009
   Duca FA, 2015, NAT MED, V21, P506, DOI 10.1038/nm.3787
   Dykens JA, 2008, TOXICOL APPL PHARM, V233, P203, DOI 10.1016/j.taap.2008.08.013
   Eamin EE, 2013, J NUTR, V143, P1872, DOI 10.3945/jn.113.179549
   El-Mir MY, 2000, J BIOL CHEM, V275, P223, DOI 10.1074/jbc.275.1.223
   Evans JMM, 2005, BMJ-BRIT MED J, V330, P1304, DOI 10.1136/bmj.38415.708634.F7
   Foretz M, 2010, J CLIN INVEST, V120, P2355, DOI 10.1172/JCI40671
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Franceschi C, 2014, J GERONTOL A-BIOL, V69, pS4, DOI 10.1093/gerona/glu057
   Fullerton MD, 2013, NAT MED, V19, P1649, DOI 10.1038/nm.3372
   Geerling JJ, 2014, DIABETES, V63, P880, DOI 10.2337/db13-0194
   Gore DC, 2005, ANN SURG, V241, P334, DOI 10.1097/01.sla.0000152013.23032.d1
   Gormsen LC, 2016, J NUCL MED, V57, P1920, DOI 10.2967/jnumed.116.177774
   Grosskopf I, 1997, DIABETES CARE, V20, P1598, DOI 10.2337/diacare.20.10.1598
   Guasch-Ferre M, 2016, DIABETES CARE, V39, P833, DOI 10.2337/dc15-2251
   Hashemitabar M, 2015, BIOMED REP, V3, P721, DOI 10.3892/br.2015.476
   Hattori Y, 2006, HYPERTENSION, V47, P1183, DOI 10.1161/01.HYP.0000221429.94591.72
   He L, 2015, CELL METAB, V21, P159, DOI 10.1016/j.cmet.2015.01.003
   He L, 2009, CELL, V137, P635, DOI 10.1016/j.cell.2009.03.016
   HOLLUNGER G, 1955, Acta Pharmacol Toxicol (Copenh), V11, P1
   Hume WE, 2013, BIOORGAN MED CHEM, V21, P7584, DOI 10.1016/j.bmc.2013.10.041
   Hundal RS, 2000, DIABETES, V49, P2063, DOI 10.2337/diabetes.49.12.2063
   Hunter RW, 2018, NAT MED, V24, P1395, DOI 10.1038/s41591-018-0159-7
   Inzucchi SE, 2012, DIABETES CARE, V35, P1364, DOI 10.2337/dc12-0413
   JEPPESEN J, 1994, DIABETES CARE, V17, P1093, DOI 10.2337/diacare.17.10.1093
   Karise I, 2019, BIOMED PHARMACOTHER, V111, P1156, DOI 10.1016/j.biopha.2019.01.021
   Kim EK, 2016, MEDIAT INFLAMM, V2016, DOI 10.1155/2016/5813030
   Kim MH, 2014, J ENDOCRINOL, V220, P117, DOI 10.1530/JOE-13-0381
   Kimura Naoko, 2005, Drug Metab Pharmacokinet, V20, P379, DOI 10.2133/dmpk.20.379
   Kita Y, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0043056
   Koepsell H, 2007, PHARM RES-DORDR, V24, P1227, DOI 10.1007/s11095-007-9254-z
   Koffert JP, 2017, DIABETES RES CLIN PR, V131, P208, DOI 10.1016/j.diabres.2017.07.015
   Kristensen JM, 2014, AM J PHYSIOL-ENDOC M, V306, pE1099, DOI 10.1152/ajpendo.00417.2013
   Landman GWD, 2010, DIABETES CARE, V33, P322, DOI 10.2337/dc09-1380
   Larsen S, 2012, DIABETOLOGIA, V55, P443, DOI 10.1007/s00125-011-2340-0
   Li Y, 2011, CELL METAB, V13, P376, DOI 10.1016/j.cmet.2011.03.009
   Luo T, 2016, DIABETES, V65, P2295, DOI 10.2337/db15-1122
   Madiraju AK, 2014, NATURE, V510, P542, DOI 10.1038/nature13270
   Mannucci E, 2004, DIABETES NUTR METAB, V17, P336
   Martin-Montalvo A, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms3192
   Masuda S, 2006, J AM SOC NEPHROL, V17, P2127, DOI 10.1681/ASN.2006030205
   Meng SM, 2015, J BIOL CHEM, V290, P3793, DOI 10.1074/jbc.M114.604421
   Meyerhof O, 1921, PFLUG ARCH GES PHYS, V188, P114, DOI 10.1007/BF01721972
   Miller RA, 2013, NATURE, V494, P256, DOI 10.1038/nature11808
   Muller J, 2005, BIOCHEM PHARMACOL, V70, P1851, DOI 10.1016/j.bcp.2005.09.011
   Musi N, 2002, DIABETES, V51, P2074, DOI 10.2337/diabetes.51.7.2074
   Napolitano A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100778
   Nygaard EB, 2012, EXP DIABETES RES, DOI 10.1155/2012/465282
   Okamura H, 2007, CELL BIOL INT, V31, P119, DOI 10.1016/j.cellbi.2006.09.014
   Oliveira AG, 2016, BMC CANCER, V16, DOI 10.1186/s12885-016-2424-9
   Ouyang JY, 2011, J BIOL CHEM, V286, P1, DOI 10.1074/jbc.M110.121806
   Owen MR, 2000, BIOCHEM J, V348, P607, DOI 10.1042/0264-6021:3480607
   Petersen KF, 2004, NEW ENGL J MED, V350, P664, DOI 10.1056/NEJMoa031314
   Polianskyte-Prause Z, 2019, FASEB J, V33, P2858, DOI 10.1096/fj.201800529RR
   Preiss D, 2016, DIABETIC MED, V33, P1569, DOI 10.1111/dme.13097
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Ridaura VK, 2013, SCIENCE, V341, P1079, DOI 10.1126/science.1241214
   Said A, 2017, ANN HEPATOL, V16, P538, DOI 10.5604/01.3001.0010.0284
   Sato T, 2008, BIOCHEM PHARMACOL, V76, P894, DOI 10.1016/j.bcp.2008.07.005
   Scarpello JHB, 1998, DIABETIC MED, V15, P651, DOI 10.1002/(SICI)1096-9136(199808)15:8<651::AID-DIA628>3.0.CO;2-A
   Schommers P, 2017, MOL METAB, V6, P737, DOI 10.1016/j.molmet.2017.05.002
   Shaw RJ, 2005, SCIENCE, V310, P1642, DOI 10.1126/science.1120781
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Shingaki T, 2015, PHARM RES-DORDR, V32, P2538, DOI 10.1007/s11095-015-1642-1
   Shu Y, 2008, CLIN PHARMACOL THER, V83, P273, DOI 10.1038/sj.clpt.6100275
   Song SM, 2001, AM J PHYSIOL-ENDOC M, V281, pE275, DOI 10.1152/ajpendo.2001.281.2.E275
   Soty M, 2015, MOL METAB, V4, P106, DOI 10.1016/j.molmet.2014.12.009
   Sterne J., 1957, MAROC MED, V36, P1295
   Stevanovic D, 2012, NEUROENDOCRINOLOGY, V96, P24, DOI 10.1159/000333963
   STUMVOLL M, 1995, NEW ENGL J MED, V333, P550, DOI 10.1056/NEJM199508313330903
   Takashima M, 2010, DIABETES, V59, P1608, DOI 10.2337/db09-1679
   Tanret G, 1914, CR HEBD ACAD SCI, V158, P1182
   Toyama EQ, 2016, SCIENCE, V351, P275, DOI 10.1126/science.aab4138
   TUCKER GT, 1981, BRIT J CLIN PHARMACO, V12, P235
   Vasamsetti SB, 2015, DIABETES, V64, P2028, DOI 10.2337/db14-1225
   Victor VM, 2015, EUR J ENDOCRINOL, V173, P683, DOI 10.1530/EJE-15-0572
   Virtanen KA, 2003, DIABETES, V52, P283, DOI 10.2337/diabetes.52.2.283
   Walford GA, 2013, METABOLISM, V62, P1772, DOI 10.1016/j.metabol.2013.07.003
   Wang C, 2014, CLIN LAB, V60, P887, DOI 10.7754/Clin.Lab.2013.130531
   Wang Y, 2019, CELL REP, V29, P1511, DOI 10.1016/j.celrep.2019.09.070
   Watanabe CK, 1918, J BIOL CHEM, V33, P253
   Wijsman CA, 2011, AGING CELL, V10, P114, DOI 10.1111/j.1474-9726.2010.00650.x
   WILCOCK C, 1991, J PHARM PHARMACOL, V43, P442, DOI 10.1111/j.2042-7158.1991.tb03507.x
   WILCOCK C, 1994, XENOBIOTICA, V24, P49, DOI 10.3109/00498259409043220
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Xu T, 2015, DIABETES CARE, V38, P1858, DOI 10.2337/dc15-0658
   Zang MW, 2004, J BIOL CHEM, V279, P47898, DOI 10.1074/jbc.M408149200
   Zhang CS, 2016, CELL METAB, V24, P521, DOI 10.1016/j.cmet.2016.09.003
   Zhou GC, 2001, J CLIN INVEST, V108, P1167, DOI 10.1172/JCI200113505
   Zhou MY, 2007, DRUG METAB DISPOS, V35, P1956, DOI 10.1124/dmd.107.015495
NR 105
TC 61
Z9 66
U1 0
U2 17
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 0165-6147
EI 1873-3735
J9 TRENDS PHARMACOL SCI
JI Trends Pharmacol. Sci.
PD NOV
PY 2020
VL 41
IS 11
BP 868
EP 881
DI 10.1016/j.tips.2020.09.001
PG 14
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA OD3RA
UT WOS:000579769000007
PM 32994049
OA Green Accepted
DA 2023-06-08
ER

PT J
AU Greenway, F
   Wang, S
   Heiman, M
AF Greenway, F.
   Wang, S.
   Heiman, M.
TI A novel cobiotic containing a prebiotic and an antioxidant augments the
   glucose control and gastrointestinal tolerability of metformin: a case
   report
SO BENEFICIAL MICROBES
LA English
DT Article
DE beta-glucan; inulin; diarrhoea
ID HIGH-FAT DIET; GUT MICROBIOTA; INSULIN SENSITIVITY; BETA-GLUCAN;
   VISCOSITY; ENDOTOXEMIA; OBESITY; RISK
AB The gut microbiome plays an important role in regulation of metabolic processes, including digestion, absorption, and synthesis of bioactive molecules that signal physiological host mechanisms. Changes in the human gut microbiome are associated with type 2 diabetes and insulin resistance. Water-soluble dietary fibres like inulin and beta-glucan are fermented in the colon, and beta-glucan increases viscosity. Blueberries improve insulin sensitivity through an antioxidant effect. A cobiotic, consisting of purified inulin, sugar-free blueberry pomace extract, and an oat preparation of purified beta-glucan was developed for twice a day (bid) consumption as a smoothie drink to repair the gastrointestinal dysbiosis in type 2 diabetes. A 30-year-old man presented with new onset type 2 diabetes and a fasting glucose (FBS) of 375 mg/dl. Metformin 500 mg bid was initiated and increased to 1 g bid after 1 week. During the first 9 days of metformin treatment, he developed diarrhoea, but his FBS only dropped to 325 mg/dl. The cobiotic bid was added on the 9th day of metformin treatment, and after 2 days, his FBS dropped to 175 mg/dl. After 8 weeks on metformin and the cobiotic, his blood sugar was 100 mg/dl and he lost 5.5 kg. His stools became soft and formed on the cobiotic, reverted to diarrhoea when off of it for 2 days, and returned to normal on resuming the cobiotic formulation. Metformin is a safe, effective and inexpensive generic medication favouring weight loss, recommended as initial treatment of type 2 diabetes by the American Diabetes Association. However, a 20% incidence of diarrhoea limits its tolerability. A safe food supplement that can increase the efficacy of metformin and its tolerability, as occurred in this case report, would have significant positive public health consequences. A controlled clinical trial of the cobiotic with metformin is planned.
C1 [Greenway, F.; Wang, S.] Louisiana State Univ Syst, Pennington Biomed Res Ctr, Outpatient Clin, Baton Rouge, LA 70808 USA.
   [Wang, S.] Chinese Peoples Liberat Army Gen Hosp, Med Sch Chinese PLA, Beijing, Peoples R China.
   [Heiman, M.] NuMe LLC, New Orleans, LA 70112 USA.
C3 Louisiana State University System; Louisiana State University;
   Pennington Biomedical Research Center; Chinese People's Liberation Army
   General Hospital
RP Greenway, F (通讯作者)，Louisiana State Univ Syst, Pennington Biomed Res Ctr, Outpatient Clin, 6400 Perkins Rd, Baton Rouge, LA 70808 USA.
EM frank.greenway@pbrc.edu
CR [Anonymous], 2012, DIABETES CARE, V35, pS11, DOI [10.2337/dc12-s004, 10.2337/dc35-S011, 10.2337/dc12-s011]
   Bays H, 2011, NUTR METAB, V8, DOI 10.1186/1743-7075-8-58
   Beckmann L, 2006, J BASIC MICROB, V46, P175, DOI 10.1002/jobm.200510107
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   DANDONA P, 1983, DIABETES CARE, V6, P472, DOI 10.2337/diacare.6.5.472
   DeFronzo RA, 2011, DIABETES CARE, V34, pS202, DOI 10.2337/dc11-s221
   Dikeman CL, 2006, J NUTR, V136, P913, DOI 10.1093/jn/136.4.913
   El Khoury D, 2012, J NUTR METAB, V2012, DOI [10.1155/2012/703490, 10.1155/2012/851362]
   Goldberg RB, 2009, DIABETES CARE, V32, P726, DOI 10.2337/dc08-0494
   Greenway F, 2007, J MED FOOD, V10, P720, DOI 10.1089/jmf.2007.405
   Inzucchi SE, 2012, DIABETES CARE, V35, P1364, DOI 10.2337/dc12-0413
   ISAKSSON G, 1982, GASTROENTEROLOGY, V82, P918
   Licht TR, 2006, BMC MICROBIOL, V6, DOI 10.1186/1471-2180-6-98
   Manach C, 2004, AM J CLIN NUTR, V79, P727, DOI 10.1093/ajcn/79.5.727
   Pendyala S, 2012, GASTROENTEROLOGY, V142, P1100, DOI 10.1053/j.gastro.2012.01.034
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Stull AJ, 2010, J NUTR, V140, P1764, DOI 10.3945/jn.110.125336
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Vijay-Kumar M, 2010, SCIENCE, V328, P228, DOI 10.1126/science.1179721
   Vitaglione P, 2009, APPETITE, V53, P338, DOI 10.1016/j.appet.2009.07.013
NR 20
TC 28
Z9 41
U1 2
U2 50
PU WAGENINGEN ACADEMIC PUBLISHERS
PI WAGENINGEN
PA PO BOX 220, WAGENINGEN, 6700 AE, NETHERLANDS
SN 1876-2883
EI 1876-2891
J9 BENEF MICROBES
JI Benef. Mirbobes
PD MAR
PY 2014
VL 5
IS 1
BP 29
EP 32
DI 10.3920/BM2012.0063
PG 4
WC Microbiology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology; Nutrition & Dietetics
GA AD3HH
UT WOS:000333128400004
PM 23685372
DA 2023-06-08
ER

PT J
AU Deng, WL
   Li, F
   Ke, HR
   Wang, SQ
   Li, ZT
   Lv, PJ
   Chen, Y
AF Deng, Wenlin
   Li, Fang
   Ke, Haoran
   Wang, Siqi
   Li, Zitong
   Lv, Pinjing
   Chen, Ye
TI Effect of metformin in autistic BTBR T+Itpr3tf/J mice administered a
   high-fat diet
SO BRAIN RESEARCH BULLETIN
LA English
DT Article
DE Autism; Sociality; High-fat diet; Metformin; Microbiome; Serotonin
ID MOUSE MODEL; SPECTRUM DISORDER; OBESITY; INFLAMMATION; BEHAVIORS;
   CHILDREN; MEMORY; CELLS; ACID
AB The biological mechanisms linking diet-related obesity and autism-related behaviors remain unclear. We aimed to characterize these interactions, focusing on gut microbiota, 5-hydroxytryptamine (5-HT) levels, and autistic behaviors in an animal model for autism; a high-fat diet (HFD) BTBR T + Itpr3tf/J (BTBR) mouse. In this model, we also examined the medication effects of metformin (Met) which is known to ameliorate several symptoms of autism spectrum disorder (ASD). Therefore, we hypothesized that HFD exacerbates BTBR autistic symptoms, which can be alleviated by Met, and the effects are associated with semtonin and the microbiota. As expected, compared with mice fed a normal diet, ten-week HFD-fed mice showed increased body weight, adiposity, and glucose levels. HFD consumption markedly aggravated repetitive behaviors in the self-grooming test. Met reduced HFD-induced hyperactivity. Notably, HFD intervention rescued sociability in the three-chamber sociability test. Furthermore, HFD stimulated tryptophan production, which was inhibited by Met. In contrast, 5-HT levels were lower in the gut and higher in the cortex in the HFD group. Moreover, Met suppressed inflammation in the hippocampus of HFD-fed mice by significantly downregulating the expression of pro-inflammatory cytokines (NF-kappa B, IL-17A, and IL-6). HFD increased the Firmicutes/Bacteroidetes ratio, and Met supplementation decreased richness while increasing bacterial diversity. We found that the abundance of gut microbiota (Lachnoclostridium, Anaerotruncus, Mucispirillum, and Lactococcus) was correlated with behavior scores and 5-HT levels. Overall, HFD consumption improved sociality in BTBR mice, which was related to the modulation of 5-HT levels and the composition of the microbiota. Met did not show any significant positive effects on the autism phenotype associated with HFD.
C1 [Deng, Wenlin; Ke, Haoran; Wang, Siqi; Li, Zitong; Lv, Pinjing; Chen, Ye] Southern Med Univ, Nanfang Hosp, Dept Gastroenterol, State Key Lab Organ Failure Res, Guangzhou 510515, Guangdong, Peoples R China.
   [Deng, Wenlin] Sun Yat Sen Univ, Affiliated Hosp 6, Dept Pediat, Guangzhou 510655, Peoples R China.
   [Li, Fang] Hainan Med Univ, Hainan Gen Hosp, Hainan Affiliated Hosp, Dept Gastroenterol,Gastroenterol Endoscopy Ctr, Haikou 570311, Hainan, Peoples R China.
C3 Southern Medical University - China; Sun Yat Sen University; Hainan
   Medical University
RP Chen, Y (通讯作者)，Southern Med Univ, Dept Gastroenterol, State Key Lab Organ Failure Res, Guangdong Prov Key Lab Gastroenterol,Nanfang Hosp, 1838 North Guangzhou Rd, Guangzhou 510515, Peoples R China.
EM yechen@smu.edu.cn
FU National Natural Science Foundation of China [81770529, 82100609];
   Hainan Provincial Natural Science Foundation of China [821QN0982];
   Guangdong Gastrointestinal Disease Research Center [2017B02029003]
FX This work was supported by the National Natural Science Foundation of
   China [grant numbers 81770529 and 82100609] , Hainan Provincial Natural
   Science Foundation of China (NO. 821QN0982) and the Guangdong
   Gastrointestinal Disease Research Center [grant number 2017B02029003] .
CR Agirman G, 2021, SCIENCE, V374, P1087, DOI 10.1126/science.abi6087
   Ahmad SF, 2021, NEUROTOXICOLOGY, V82, P9, DOI 10.1016/j.neuro.2020.10.014
   Ahmad SF, 2019, PSYCHOPHARMACOLOGY, V236, P831, DOI 10.1007/s00213-018-5120-4
   Ahmad SF, 2018, EUR J PHARMACOL, V829, P70, DOI 10.1016/j.ejphar.2018.04.008
   American Psychiatric Association, 2022, DIAGNOSTIC STAT MANU, V5th
   Amodeo DA, 2016, BEHAV BRAIN RES, V313, P67, DOI 10.1016/j.bbr.2016.06.064
   Angoa-Perez M., 2013, COMPULS BEHAV MICE J
   Asghar A, 2017, CELL IMMUNOL, V315, P18, DOI 10.1016/j.cellimm.2017.03.001
   Banskota S, 2019, BIOCHIMIE, V161, P56, DOI 10.1016/j.biochi.2018.06.008
   Bellono NW, 2017, CELL, V170, DOI 10.1016/j.cell.2017.05.034
   Chao OY, 2018, BEHAV BRAIN RES, V347, P140, DOI 10.1016/j.bbr.2018.03.014
   Coretti L, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.03146
   Corvey K, 2016, MATERN CHILD HLTH J, V20, P466, DOI 10.1007/s10995-015-1844-5
   Curtin C, 2014, HARVARD REV PSYCHIAT, V22, P93, DOI 10.1097/HRP.0000000000000031
   Eudave DM, 2018, NEUROBIOL STRESS, V9, P1, DOI 10.1016/j.ynstr.2018.05.005
   Fatima Z, 2018, TOXICOL RES-UK, V7, P1020, DOI 10.1039/c8tx00102b
   Gantois I, 2017, NAT MED, V23, P674, DOI 10.1038/nm.4335
   Garbarino VR, 2019, PHARMACOL RES, V140, P21, DOI 10.1016/j.phrs.2018.11.013
   Gawlinska K, 2021, NUTRIENTS, V13, DOI 10.3390/nu13093212
   Golubeva AV, 2017, EBIOMEDICINE, V24, P166, DOI 10.1016/j.ebiom.2017.09.020
   Handen BL, 2017, J AM ACAD CHILD PSY, V56, P849, DOI 10.1016/j.jaac.2017.07.790
   Hill AP, 2015, PEDIATRICS, V136, P1051, DOI 10.1542/peds.2015-1437
   Israelyan N, 2018, PHARMACOL RES, V132, P1, DOI 10.1016/j.phrs.2018.03.020
   Jeon BT, 2012, DIABETES, V61, P1444, DOI 10.2337/db11-1498
   Ji SQ, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00704
   Kang DW, 2017, MICROBIOME, V5, DOI 10.1186/s40168-016-0225-7
   Ke HR, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.726707
   Krishna S, 2016, PHYSIOL BEHAV, V157, P196, DOI 10.1016/j.physbeh.2016.02.007
   Levy SE, 2019, J PEDIATR-US, V205, P202, DOI 10.1016/j.jpeds.2018.09.003
   Li QR, 2017, FRONT CELL NEUROSCI, V11, DOI 10.3389/fncel.2017.00120
   Liu F, 2018, MOL AUTISM, V9, DOI 10.1186/s13229-018-0251-3
   Luo C, 2019, FRONT PHARMACOL, V10, DOI 10.3389/fphar.2019.00371
   Ma BJ, 2019, FRONT CELL INFECT MI, V9, DOI 10.3389/fcimb.2019.00040
   Ma W, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.01336
   Mamo JCL, 2019, DIABETES VASC DIS RE, V16, P87, DOI 10.1177/1479164118795274
   Mandwie M., 2021, INT J MOL SCI, V22
   Marler S, 2016, J AUTISM DEV DISORD, V46, P1124, DOI 10.1007/s10803-015-2646-8
   Mawe GM, 2013, NAT REV GASTRO HEPAT, V10, P473, DOI 10.1038/nrgastro.2013.105
   Mirza R, 2019, BRAIN RES BULL, V147, P36, DOI 10.1016/j.brainresbull.2019.02.003
   Moaaz M, 2019, J NEUROIMMUNOL, V337, DOI 10.1016/j.jneuroim.2019.577071
   Muller CL, 2016, NEUROSCIENCE, V321, P24, DOI 10.1016/j.neuroscience.2015.11.010
   Nadeem A, 2020, PROG NEURO-PSYCHOPH, V97, DOI 10.1016/j.pnpbp.2019.109783
   Nadeem A, 2018, PROG NEURO-PSYCHOPH, V83, P8, DOI 10.1016/j.pnpbp.2017.12.015
   Nagy C, 2018, JOVE-J VIS EXP, DOI 10.3791/56672
   Penagarikano O, 2011, CELL, V147, P235, DOI 10.1016/j.cell.2011.08.040
   Rajan TM, 2017, J POSTGRAD MED, V63, P182, DOI 10.4103/jpgm.JPGM_712_16
   Rohr MW, 2020, ADV NUTR, V11, P77, DOI 10.1093/advances/nmz061
   Ross HE, 2013, BRAIN BEHAV IMMUN, V31, P76, DOI 10.1016/j.bbi.2012.12.021
   Rutsch A, 2020, FRONT IMMUNOL, V11, DOI 10.3389/fimmu.2020.604179
   Sauer AK, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20092134
   Schoonejans JM, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22158104
   Schuiveling M, 2018, CURR DRUG TARGETS, V19, P945, DOI 10.2174/1389450118666170613081730
   Schuster F, 2018, PFLUG ARCH EUR J PHY, V470, P1673, DOI 10.1007/s00424-018-2178-0
   Seibenhener ML, 2015, JOVE-J VIS EXP, DOI 10.3791/52434
   Sgritta M, 2019, NEURON, V101, P246, DOI 10.1016/j.neuron.2018.11.018
   Silamikele L, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.626359
   Silverman JL, 2013, NEUROPHARMACOLOGY, V68, P210, DOI 10.1016/j.neuropharm.2012.07.042
   Sullivan Elinor L, 2012, Int J Obes Suppl, V2, pS7
   Takase K, 2016, OBESITY, V24, P886, DOI 10.1002/oby.21441
   Tan BL, 2019, NUTRIENTS, V11, DOI 10.3390/nu11112579
   Tanokashira D, 2018, FEBS OPEN BIO, V8, P1104, DOI 10.1002/2211-5463.12436
   Wang L, 2018, FRONT BEHAV NEUROSCI, V12, DOI 10.3389/fnbeh.2018.00290
   Xiao L, 2021, MSYSTEMS, V6, DOI 10.1128/mSystems.01343-20
   Yang YJ, 2019, NEUROPSYCHOPHARMACOL, V44, P2054, DOI 10.1038/s41386-019-0437-1
   Zemdegs J, 2019, J NEUROSCI, V39, P5935, DOI 10.1523/JNEUROSCI.2904-18.2019
   Zhang Q, 2021, PEERJ, V9, DOI 10.7717/peerj.10946
   Zilkha N, 2017, NEUROSCIENCE, V345, P142, DOI 10.1016/j.neuroscience.2016.01.070
NR 67
TC 6
Z9 6
U1 4
U2 10
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0361-9230
EI 1873-2747
J9 BRAIN RES BULL
JI Brain Res. Bull.
PD JUN 1
PY 2022
VL 183
BP 172
EP 183
DI 10.1016/j.brainresbull.2022.02.021
EA MAR 2022
PG 12
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 5E9OK
UT WOS:000865950600004
PM 35240246
DA 2023-06-08
ER

PT J
AU Li, QZ
   He, R
   Zhang, FM
   Zhang, J
   Lian, SH
   Liu, HX
AF Li, Qingzhong
   He, Rui
   Zhang, Fengmei
   Zhang, Jian
   Lian, Shihai
   Liu, Hongxia
TI Combination of Oligofructose and Metformin Alters the Gut Microbiota and
   Improves Metabolic Profiles, Contributing to the Potentiated Therapeutic
   Effects on Diet-Induced Obese Animals
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE metformin; oligofructose; gut microbiota; obesity; T2DM
ID AMERICAN-DIABETES-ASSOCIATION; EUROPEAN ASSOCIATION; INSULIN;
   HYPERGLYCEMIA; MANAGEMENT; STATEMENT; GENETICS
AB Accumulating studies implicate that the metformin (MET)- and oligofructose (OFS)-altered gut microbiota may play roles in the improvement of type 2 diabetes mellitus (T2DM) and obesity. However, whether the combined administration of OFS and MET could effectively affect the gut microbiota and improve metabolic profiles remains unknown. Here, we randomized diet-induced obesity (DIO) rats to OFS, MET, or MET+OFS for 8 weeks and demonstrated that the combined administration of OFS+MET possessed potentiated effects on the glycemia, body weight, and gut microbiome. In addition, fecal samples from the MET and MET+OFS group were exchanged and transferred to germ-free rats induced by antibiotics. Not surprisingly, the glucose tolerance and serum levels of endotoxin, free fatty acids (FFA), tumor necrosis factor-alpha (TNF-alpha), interleukin-2 (IL-2), and interleukin-6 (IL-6) were all sustainably improved among OFS+MET fecal microbiota-treated DIO rats while the MET fecal microbiota-treated ones presented a relatively reverse trend. Furthermore, transfer of fecal samples from the rats after 8 weeks of treatment to antibiotics-treated germ-free mice significantly improved metabolic profiles, including glucose tolerance and weight reduction in mice that received MET+OFS-altered microbiota. In conclusion, the present study illustrated that the effects of OFS and MET combined treatment on gut microbiota, especially for the MET-induced side effect-related ones, and host metabolism were of greater magnitude than individual OFS or MET treatment in obese rats and mice. Therefore, it is likely that combined administration of OFS and MET may offer a novel and promising strategy for reducing side effects induced by MET and improving metabolic outcomes, particularly glycemia control and weight reduction.
C1 [Li, Qingzhong; Liu, Hongxia] Binzhou Med Univ, Sch Pharm, Dept Clin Pharm, Yantai, Peoples R China.
   [He, Rui] Shandong First Med Univ & Shandong Acad Med Sci, Tai An, Shandong, Peoples R China.
   [Zhang, Fengmei] Binzhou Med Univ, Dept Rehabil Med, Affiliated Hosp, Binzhou, Peoples R China.
   [Zhang, Jian] Taian City Cent Hosp, Dept Endocrinol 2, Tai An, Shandong, Peoples R China.
   [Lian, Shihai] Zaozhuang Municipal Hosp, Dept Thorac Surg, Zaozhuang, Peoples R China.
C3 Binzhou Medical University; Shandong First Medical University & Shandong
   Academy of Medical Sciences; Binzhou Medical University
RP Li, QZ (通讯作者)，Binzhou Med Univ, Sch Pharm, Dept Clin Pharm, Yantai, Peoples R China.
EM qzli88@ncstmc.cn
FU Natural Science Foundation of Shandong Province, China [ZR2013HL007];
   Science and Technology Plan of Universities of Shandong Province
   [J12LM03]; Science Research Program of Binzhou Medical University
   [BY2011KYQD06]
FX This work was supported by the Natural Science Foundation of Shandong
   Province, China (ZR2013HL007), the Science and Technology Plan of
   Universities of Shandong Province (J12LM03), and the Science Research
   Program of Binzhou Medical University (BY2011KYQD06).
CR Rojas LBA, 2013, DIABETOL METAB SYNDR, V5, DOI 10.1186/1758-5996-5-6
   Aksay E, 2007, TURK J MED SCI, V37, P173
   Arboleya S, 2016, FRONT MICROBIOL, V7, DOI 10.3389/fmicb.2016.01204
   Bao B, 2011, BBA-REV CANCER, V1815, P135, DOI 10.1016/j.bbcan.2010.11.003
   Bjorkhem-Bergman L, 2011, J PSYCHOPHARMACOL, V25, P299, DOI 10.1177/0269881109353461
   Bomhof MR, 2014, OBESITY, V22, P763, DOI 10.1002/oby.20632
   Tonucci L, 2017, CRIT REV FOOD SCI, V57, P2296, DOI 10.1080/10408398.2014.934438
   Chaput JP, 2014, CURR OBES REP, V3, P54, DOI 10.1007/s13679-013-0086-3
   Chen S, 2019, FOOD FUNCT, V10, P366, DOI [10.1039/c8fo02161a, 10.1039/C8FO02161A]
   Cicek B, 2009, PAK J MED SCI, V25, P573
   Conterno L, 2011, GENES NUTR, V6, P241, DOI 10.1007/s12263-011-0230-1
   CZYZYK A, 1968, DIABETES, V17, P492, DOI 10.2337/diab.17.8.492
   Delzenne NM, 2011, NAT REV ENDOCRINOL, V7, P639, DOI 10.1038/nrendo.2011.126
   Diamant M, 2011, OBES REV, V12, P272, DOI 10.1111/j.1467-789X.2010.00797.x
   Dujic T, 2016, DIABETIC MED, V33, P511, DOI 10.1111/dme.13040
   Faulkner G, 2015, EVID-BASED MENT HEAL, V18, P89, DOI 10.1136/eb-2014-102039
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Hoffmann Irene S, 2003, Am J Ther, V10, P447, DOI 10.1097/00045391-200311000-00012
   Inzucchi SE, 2015, DIABETES CARE, V38, P140, DOI 10.2337/dc14-2441
   Jou C, 2014, NEW ENGL J MED, V370, P1874, DOI 10.1056/NEJMp1400613
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Levin BE, 2010, FRONT NEUROENDOCRIN, V31, P270, DOI 10.1016/j.yfrne.2010.02.005
   Ley RE, 2006, NATURE, V444, P1022, DOI 10.1038/4441022a
   Madiraju AK, 2014, NATURE, V510, P542, DOI 10.1038/nature13270
   Martinez JA, 2016, BMC CANCER, V16, DOI 10.1186/s12885-016-2551-3
   Messori S, 2013, VET MICROBIOL, V162, P173, DOI 10.1016/j.vetmic.2012.09.001
   Monk JM, 2016, J NUTR BIOCHEM, V28, P129, DOI 10.1016/j.jnutbio.2015.10.014
   Nathan DM, 2009, DIABETES CARE, V32, P193, DOI 10.2337/dc08-9025
   Pernicova I, 2014, NAT REV ENDOCRINOL, V10, P143, DOI 10.1038/nrendo.2013.256
   Schott EM, 2018, JCI INSIGHT, V3, DOI 10.1172/jci.insight.95997
   Shen J, 2013, MOL ASPECTS MED, V34, P39, DOI 10.1016/j.mam.2012.11.001
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Verdich C, 2001, INT J OBESITY, V25, P1206, DOI 10.1038/sj.ijo.0801655
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Zhang XQ, 2015, SCI REP-UK, V5, DOI 10.1038/srep10737
NR 35
TC 12
Z9 13
U1 1
U2 8
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD FEB 25
PY 2020
VL 10
AR 939
DI 10.3389/fendo.2019.00939
PG 14
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA LC3GG
UT WOS:000525212700001
PM 32158428
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Justice, JN
   Gubbi, S
   Kulkarni, AS
   Bartley, JM
   Kuchel, GA
   Barzilai, N
AF Justice, Jamie N.
   Gubbi, Sriram
   Kulkarni, Ameya S.
   Bartley, Jenna M.
   Kuchel, George A.
   Barzilai, Nir
TI A geroscience perspective on immune resilience and infectious diseases:
   a potential case for metformin
SO GEROSCIENCE
LA English
DT Article
DE Metformin; Aging; Geroscience; Immunity; COVID-19
ID CHRONIC HEPATITIS-C; T-HELPER 17; DNA-DAMAGE; HEPATOCELLULAR-CARCINOMA;
   DIABETES-MELLITUS; MAMMALIAN TARGET; GUT MICROBIOTA; LIFE-SPAN; AMPK;
   MORTALITY
AB We are in the midst of the global pandemic. Though acute respiratory coronavirus (SARS-COV2) that leads to COVID-19 infects people of all ages, severe symptoms and mortality occur disproportionately in older adults. Geroscience interventions that target biological aging could decrease risk across multiple age-related diseases and improve outcomes in response to infectious disease. This offers hope for a new host-directed therapeutic approach that could (i) improve outcomes following exposure or shorten treatment regimens; (ii) reduce the chronic pathology associated with the infectious disease and subsequent comorbidity, frailty, and disability; and (iii) promote development of immunological memory that protects against relapse or improves response to vaccination. We review the possibility of this approach by examining available evidence in metformin: a generic drug with a proven safety record that will be used in a large-scale multicenter clinical trial. Though rigorous translational research and clinical trials are needed to test this empirically, metformin may improve host immune defenses and confer protection against long-term health consequences of infectious disease, age-related chronic diseases, and geriatric syndromes.
C1 [Justice, Jamie N.] Wake Forest Sch Med, Sticht Ctr Hlth Aging & Alzheimers Prevent Intern, Med Ctr Blvd, Winston Salem, NC 27157 USA.
   [Gubbi, Sriram] NIDDK, Metab Dis Branch, NIH, Bethesda, MD 20814 USA.
   [Kulkarni, Ameya S.; Barzilai, Nir] Albert Einstein Coll Med, Dept Med, Div Endocrinol, Bronx, NY 10461 USA.
   [Kulkarni, Ameya S.; Barzilai, Nir] Albert Einstein Coll Med, Inst Aging Res, Bronx, NY 10461 USA.
   [Bartley, Jenna M.; Kuchel, George A.] Univ Connecticut, Sch Med, Ctr Aging, Farmington, CT 06030 USA.
   [Bartley, Jenna M.] Univ Connecticut, Sch Med, Dept Immunol, Farmington, CT 06030 USA.
C3 Wake Forest University; National Institutes of Health (NIH) - USA; NIH
   National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK);
   Yeshiva University; Albert Einstein College of Medicine; Yeshiva
   University; Albert Einstein College of Medicine; University of
   Connecticut; University of Connecticut
RP Justice, JN (通讯作者)，Wake Forest Sch Med, Sticht Ctr Hlth Aging & Alzheimers Prevent Intern, Med Ctr Blvd, Winston Salem, NC 27157 USA.
EM jnjustic@wakehealth.edu
RI Gubbi, Sriram/AAL-6801-2020; Kulkarni, Ameya/AAH-7996-2020; Justice,
   Jamie/AAW-9590-2021
OI Gubbi, Sriram/0000-0002-9263-1381; Kulkarni, Ameya/0000-0003-4495-8838;
   Justice, Jamie/0000-0003-2953-4404; Kuchel, George/0000-0001-8387-7040;
   Bartley, Jenna/0000-0003-0302-975X
FU American Federation of Aging Research; Glenn Center for the Biology of
   Human Aging; National Institutes of Health (NIH) [K01 AG059837, P30
   AG021332, R33 AG061456, R21 AG063528, R56 AG060746, R35 GM124922, U01
   AI124297, R21 AG060018, R01 AG058814, R01 AI142086, UH3 AG056925,
   P30AG038072]
FX The authors acknowledge the support by the American Federation of Aging
   Research (JMB, Irene Diamond AFAR award), the Glenn Center for the
   Biology of Human Aging (NB), and the National Institutes of Health
   (NIH): JNJ (K01 AG059837, P30 AG021332); GAK (R33 AG061456, R21
   AG063528, R56 AG060746, R35 GM124922, U01 AI124297, R21 AG060018, R01
   AG058814, R01 AI142086, UH3 AG056925); NB (P30AG038072).Data
   availabilityNot applicable.
CR Aatsinki SM, 2014, BRIT J PHARMACOL, V171, P2351, DOI 10.1111/bph.12585
   Agarwal D, 2018, IMMUN AGEING, V15, DOI 10.1186/s12979-018-0124-9
   Ahmadi S, 2020, J GERONTOL A-BIOL, V75, pE9, DOI 10.1093/gerona/glaa056
   Ajaimy M, 2020, CLIN J AM SOC NEPHRO, V15, P1087, DOI 10.2215/CJN.09730620
   Algire C, 2012, CANCER PREV RES, V5, P536, DOI 10.1158/1940-6207.CAPR-11-0536
   Ba W, 2019, CELL BIOCHEM FUNCT, V37, P4, DOI 10.1002/cbf.3367
   Bailey CJ, 2017, DIABETOLOGIA, V60, P1566, DOI 10.1007/s00125-017-4318-z
   Bartley JM, 2017, FRONT IMMUNOL, V8, DOI 10.3389/fimmu.2017.01164
   Barzilai N, 2016, CELL METAB, V23, P1060, DOI 10.1016/j.cmet.2016.05.011
   Bauer PV, 2018, CELL METAB, V27, P101, DOI 10.1016/j.cmet.2017.09.019
   Ben Sahra I, 2011, CANCER RES, V71, P4366, DOI 10.1158/0008-5472.CAN-10-1769
   Ben-Yehuda A, 1992, Clin Geriatr Med, V8, P701
   Blagih J, 2015, IMMUNITY, V42, P41, DOI 10.1016/j.immuni.2014.12.030
   Blanco-Melo D, 2020, CELL, V181, P1036, DOI 10.1016/j.cell.2020.04.026
   Bramante Carolyn T, 2020, medRxiv, DOI 10.1101/2020.06.19.20135095
   Bridgeman SC, 2018, DIABETES OBES METAB, V20, P1553, DOI 10.1111/dom.13262
   Brima W, 2015, DIABETES-METAB RES, V31, P346, DOI 10.1002/dmrr.2636
   Cabreiro F, 2013, CELL, V153, P228, DOI 10.1016/j.cell.2013.02.035
   Cameron AR, 2016, CIRC RES, V119, P652, DOI 10.1161/CIRCRESAHA.116.308445
   Campbell JM, 2017, AGEING RES REV, V40, P31, DOI 10.1016/j.arr.2017.08.003
   Canto C, 2009, NATURE, V458, P1056, DOI 10.1038/nature07813
   Cawthon PM, 2020, J GERONTOL A-BIOL, V75, pE123, DOI 10.1093/gerona/glaa099
   Channappanavar R, 2019, J CLIN INVEST, V129, P3625, DOI 10.1172/JCI126363
   Chen CI, 2015, MEDICINE, V94, DOI 10.1097/MD.0000000000000462
   Chen C, 2009, SCI SIGNAL, V2, DOI 10.1126/scisignal.2000559
   Chen TM, 2011, J GASTROEN HEPATOL, V26, P858, DOI 10.1111/j.1440-1746.2011.06664.x
   Chen X, 2019, J INFECT DIS, V220, P1892, DOI 10.1093/infdis/jiz413
   Chen Y, 2020, J MED VIROL, V92, P418, DOI 10.1002/jmv.25681
   Chiasson JL, 2003, JAMA-J AM MED ASSOC, V290, P486, DOI 10.1001/jama.290.4.486
   Cuyas E, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00657
   Dagenais-Lussier X, 2015, CYTOKINE GROWTH F R, V26, P603, DOI 10.1016/j.cytogfr.2015.09.001
   De Haes W, 2014, P NATL ACAD SCI USA, V111, pE2501, DOI 10.1073/pnas.1321776111
   Degner NR, 2018, CLIN INFECT DIS, V66, P198, DOI 10.1093/cid/cix819
   del Campo JA, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0191805
   Diaz A, 2017, VACCINE, V35, P2694, DOI 10.1016/j.vaccine.2017.03.078
   Dillon SM, 2017, AIDS, V31, P510, DOI 10.1097/QAD.0000000000001366
   Diman A, 2016, SCI ADV, V2, DOI 10.1126/sciadv.1600031
   Ding L, 2015, ONCOTARGET, V6, P36441, DOI 10.18632/oncotarget.5541
   Dowling RJO, 2007, CANCER RES, V67, P10804, DOI 10.1158/0008-5472.CAN-07-2310
   Doyle MA, 2016, TRIALS, V17, DOI 10.1186/s13063-016-1454-6
   DuGoff EH, 2014, MED CARE, V52, P688, DOI 10.1097/MLR.0000000000000166
   Dutta NK, 2017, ANTIMICROB AGENTS CH, V61, DOI 10.1128/AAC.00652-17
   Eikawa S, 2015, P NATL ACAD SCI USA, V112, P1809, DOI 10.1073/pnas.1417636112
   El-Mir MY, 2000, J BIOL CHEM, V275, P223, DOI 10.1074/jbc.275.1.223
   Espinoza SE, 2020, J GERONTOL A-BIOL, V75, P102, DOI 10.1093/gerona/glz078
   Fang JQ, 2018, AGING CELL, V17, DOI 10.1111/acel.12765
   Fatt M, 2015, STEM CELL REP, V5, P988, DOI 10.1016/j.stemcr.2015.10.014
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   GARCIA E Y, 1950, J Philipp Med Assoc, V26, P287
   Garnett JP, 2014, CELL MOL LIFE SCI, V71, P4665, DOI 10.1007/s00018-014-1635-y
   Garnett JP, 2013, THORAX, V68, P835, DOI 10.1136/thoraxjnl-2012-203178
   Gill SK, 2016, SCI REP-UK, V6, DOI 10.1038/srep27636
   Gonzalez-Hernandez LA, 2019, BMC INFECT DIS, V19, DOI 10.1186/s12879-019-3867-9
   Gregoire M, 2018, EUR RESPIR J, V52, DOI 10.1183/13993003.02590-2017
   Ruivo MTG, 2016, CELL REP, V16, P2539, DOI 10.1016/j.celrep.2016.08.001
   Guo T, 2020, JAMA CARDIOL, V5, P811, DOI 10.1001/jamacardio.2020.1017
   Guo YR, 2020, MILITARY MED RES, V7, DOI 10.1186/s40779-020-00240-0
   Hammerstad SS, 2015, FRONT ENDOCRINOL, V6, DOI 10.3389/fendo.2015.00134
   Harris K, 2013, ANN PHARMACOTHER, V47, P1348, DOI 10.1177/1060028013503108
   Hawley SA, 2002, DIABETES, V51, P2420, DOI 10.2337/diabetes.51.8.2420
   Hofmeister MG, 2019, HEPATOLOGY, V69, P1020, DOI 10.1002/hep.30297
   Howell JJ, 2017, CELL METAB, V25, P463, DOI 10.1016/j.cmet.2016.12.009
   Hwangbo DS, 2020, NUTRIENTS, V12, DOI 10.3390/nu12041194
   Jiang X, 2020, OXID MED CELL LONGEV, V2020, DOI 10.1155/2020/8708236
   Jiang Z, 2018, J CELL BIOCHEM, V119, P4482, DOI 10.1002/jcb.26555
   Johnson SC, 2013, NATURE, V493, P338, DOI 10.1038/nature11861
   Justice JN, 2018, CARDIOVASC ENDOCR ME, V7, P80, DOI 10.1097/XCE.0000000000000159
   Kajiwara C, 2018, J IMMUNOL, V200, P623, DOI 10.4049/jimmunol.1700474
   Kalender A, 2010, CELL METAB, V11, P390, DOI 10.1016/j.cmet.2010.03.014
   Kalsi KK, 2019, J CELL MOL MED, V23, P317, DOI 10.1111/jcmm.13929
   Kato M, 2019, NAT REV NEPHROL, V15, P327, DOI 10.1038/s41581-019-0135-6
   Kim JH, 2013, KOREAN J PHYSIOL PHA, V17, P455, DOI 10.4196/kjpp.2013.17.5.455
   Kivi M, 2021, J GERONTOL B-PSYCHOL, V76, pE4, DOI 10.1093/geronb/gbaa084
   Knowler WC, 2002, NEW ENGL J MED, V346, P393, DOI 10.1056/NEJMoa012512
   Kulkarni AS, 2020, CELL METAB, V32, P15, DOI 10.1016/j.cmet.2020.04.001
   Lachmandas E, 2019, J INFECT DIS, V220, P139, DOI 10.1093/infdis/jiz064
   Lai SW, 2012, AM J GASTROENTEROL, V107, P46, DOI 10.1038/ajg.2011.384
   Lamarca K, 2016, EXPERT OPIN PHARMACO, V17, P1327, DOI 10.1080/14656566.2016.1187133
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Lee SY, 2017, J IMMUNOL, V198, P2661, DOI 10.4049/jimmunol.1403088
   Lee YS, 2016, ONCOL REP, V35, P3735, DOI 10.3892/or.2016.4740
   Li HB, 2020, CIRC RES, V126, P533, DOI 10.1161/CIRCRESAHA.119.315889
   Lindner D, 2020, JAMA CARDIOL, V5, P1281, DOI 10.1001/jamacardio.2020.3551
   Liu J, 2020, EBIOMEDICINE, V55, DOI 10.1016/j.ebiom.2020.102763
   Luo P, 2020, AM J TROP MED HYG, V103, P69, DOI 10.4269/ajtmh.20-0375
   Ma W, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.01336
   Malik F, 2018, DIABETES-METAB RES, V34, DOI 10.1002/dmrr.2975
   Mallia P, 2018, J ALLERGY CLIN IMMUN, V142, P815, DOI 10.1016/j.jaci.2017.10.017
   Mannick JB, 2018, SCI TRANSL MED, V10, DOI 10.1126/scitranslmed.aaq1564
   Mannick JB, 2014, SCI TRANSL MED, V6, DOI 10.1126/scitranslmed.3009892
   Marcucci F, 2020, TRENDS PHARMACOL SCI, V41, P162, DOI 10.1016/j.tips.2020.01.003
   Martin-Montalvo A, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms3192
   Meftahi GH, 2020, INFLAMM RES, V69, P825, DOI 10.1007/s00011-020-01372-8
   Mehla R, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0011160
   Michalak I, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18030479
   Mitchell SJ, 2019, CELL METAB, V29, P221, DOI 10.1016/j.cmet.2018.08.011
   Miyakoda M, 2018, FRONT IMMUNOL, V9, DOI 10.3389/fimmu.2018.02942
   Moiseeva O, 2013, AGING CELL, V12, P489, DOI 10.1111/acel.12075
   Moore JB, 2020, SCIENCE, V368, P473, DOI 10.1126/science.abb8925
   Mortensen E, 2018, EUR RESPIR J, V52, DOI 10.1183/13993003.congress-2018.PA2639
   Moseley CE, 2010, INFLUENZA OTHER RESP, V4, P307, DOI 10.1111/j.1750-2659.2010.00155.x
   Na HJ, 2018, BIOCHEM BIOPH RES CO, V498, P18, DOI 10.1016/j.bbrc.2018.02.191
   Na HJ, 2013, MECH AGEING DEV, V134, P381, DOI 10.1016/j.mad.2013.07.003
   Naicker N, 2020, FRONT MICROBIOL, V11, DOI 10.3389/fmicb.2020.00435
   Nakashima K, 2011, MICROBIOL IMMUNOL, V55, P774, DOI 10.1111/j.1348-0421.2011.00382.x
   Neumann B, 2019, CELL STEM CELL, V25, P473, DOI 10.1016/j.stem.2019.08.015
   Nikolich-Zugich J, 2020, GEROSCIENCE, V42, P505, DOI 10.1007/s11357-020-00186-0
   Nkontchou G, 2011, J CLIN ENDOCR METAB, V96, P2601, DOI 10.1210/jc.2010-2415
   Noren Hooten N, 2016, AGING CELL, V15, P572, DOI 10.1111/acel.12469
   Onken B, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0008758
   Ouyang J, 2020, AIDS RES THER, V17, DOI 10.1186/s12981-020-00267-2
   Park MJ, 2016, TRANSL RES, V173, P115, DOI 10.1016/j.trsl.2016.03.006
   Patkee WRA, 2016, J CELL MOL MED, V20, P758, DOI 10.1111/jcmm.12784
   Pedersen SF, 2020, J CLIN INVEST, V130, P2202, DOI 10.1172/JCI137647
   Pereira Felipe V, 2018, Oncotarget, V9, P25808, DOI 10.18632/oncotarget.25380
   Pollak M, 2017, DIABETOLOGIA, V60, P1662, DOI 10.1007/s00125-017-4352-x
   Promislow DEL, 2020, J GERONTOL A-BIOL, V75, pE30, DOI 10.1093/gerona/glaa094
   Qing LM, 2019, AM J TRANSL RES, V11, P655
   Rangarajan S, 2018, NAT MED, V24, P1121, DOI 10.1038/s41591-018-0087-6
   Richardson S, 2020, JAMA-J AM MED ASSOC, V323, P2052, DOI 10.1001/jama.2020.6775
   Rodriguez-Carlos A, 2020, MICROBES INFECT, V22, P111, DOI 10.1016/j.micinf.2019.10.002
   Romero-Gomez M, 2009, HEPATOLOGY, V50, P1702, DOI 10.1002/hep.23206
   Rothan HA, 2020, J AUTOIMMUN, V109, DOI 10.1016/j.jaut.2020.102433
   Routy JP, 2019, BMJ OPEN, V9, DOI 10.1136/bmjopen-2018-028444
   Sarfstein R, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0061537
   Sato Y, 2019, NAT REV NEPHROL, V15, P625, DOI 10.1038/s41581-019-0185-9
   Schuiveling M, 2018, CURR DRUG TARGETS, V19, P945, DOI 10.2174/1389450118666170613081730
   Sharifi Amir Houshang, 2014, Middle East J Dig Dis, V6, P13
   Shen C, 2016, ONCOTARGET, V7, P62647, DOI 10.18632/oncotarget.11591
   Sheth SH, 2010, BMC INFECT DIS, V10, DOI 10.1186/1471-2334-10-183
   Shikuma CM, 2020, AIDS RES HUM RETROV, V36, P303, DOI [10.1089/aid.2019.0078, 10.1089/AID.2019.0078]
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Sierra F, 2020, J AM GERIATR SOC, V68, P951, DOI 10.1111/jgs.16489
   Singhal A, 2014, SCI TRANSL MED, V6, DOI 10.1126/scitranslmed.3009885
   Soukas AA, 2019, TRENDS ENDOCRIN MET, V30, P745, DOI 10.1016/j.tem.2019.07.015
   Statistics C.N, 2020, COVID 19 DEATH DAT R
   Sun YF, 2016, J NEUROIMMUNOL, V292, P58, DOI 10.1016/j.jneuroim.2016.01.014
   Tizazu AM, 2019, FRONT PHYSIOL, V10, DOI 10.3389/fphys.2019.00572
   Tsai HH, 2017, ONCOTARGET, V8, P13832, DOI 10.18632/oncotarget.14640
   Turner RC, 1998, LANCET, V352, P854, DOI 10.1016/s0140-6736(98)07037-8
   Uehara T, 2019, INT IMMUNOL, V31, P187, DOI 10.1093/intimm/dxy079
   Vasamsetti SB, 2015, DIABETES, V64, P2028, DOI 10.2337/db14-1225
   Vazquez-Martin A, 2011, CELL CYCLE, V10, P1499, DOI 10.4161/cc.10.9.15423
   Velavan TP, 2020, TROP MED INT HEALTH, V25, P278, DOI 10.1111/tmi.13383
   Vera IM, 2019, JCI INSIGHT, V4, DOI 10.1172/jci.insight.127441
   Wang CP, 2017, J DIABETES COMPLICAT, V31, P679, DOI [10.1016/jjdiacomp.2017.01.013, 10.1016/j.jdiacomp.2017.01.013]
   Wang DW, 2020, JAMA-J AM MED ASSOC, V323, P1061, DOI 10.1001/jama.2020.1585
   Wang GY, 2017, INT J MED SCI, V14, P698, DOI 10.7150/ijms.19800
   Wang GZ, 2016, EXP THER MED, V12, P1551, DOI 10.3892/etm.2016.3465
   Wang Y, 2018, J EXP CLIN CANC RES, V37, DOI 10.1186/s13046-018-0731-5
   Wheaton WW, 2014, ELIFE, V3, DOI 10.7554/eLife.02242
   Williamson E., 2020, OPENSAFELY FACTORS A, DOI [10.1101/2020.05.06.20092999:2020.2005.2006.20092999, DOI 10.1101/2020.05.06.20092999, 10.1101/2020.05.06.20092999]
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Wu J, 2020, CLIN J AM SOC NEPHRO, V15, P1139, DOI 10.2215/CJN.04160320
   Xiao Y, 2020, VIRULENCE, V11, P39, DOI 10.1080/21505594.2019.1706305
   Xun YH, 2014, J VIRAL HEPATITIS, V21, P597, DOI 10.1111/jvh.12187
   Ye Q, 2020, J INFECTION, V80, P607, DOI 10.1016/j.jinf.2020.03.037
   Yen FS, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-67338-2
   Yew WW, 2019, TUBERCULOSIS, V115, P76, DOI 10.1016/j.tube.2019.02.004
   Yoshikawa TT, 2000, CLIN INFECT DIS, V30, P931, DOI 10.1086/313792
   Yousefzadeh MJ, 2018, EBIOMEDICINE, V36, P18, DOI 10.1016/j.ebiom.2018.09.015
   Yu JW, 2012, INT J INFECT DIS, V16, pE436, DOI 10.1016/j.ijid.2012.02.004
   Yu LL, 2018, EUR REV MED PHARMACO, V22, P5355, DOI 10.26355/eurrev_201808_15737
   Zhang CS, 2016, CELL METAB, V24, P521, DOI 10.1016/j.cmet.2016.09.003
   Zhang XQ, 2015, SCI REP-UK, V5, DOI 10.1038/srep10737
   Zhou F, 2020, LANCET, V395, P1054, DOI 10.1016/S0140-6736(20)30566-3
   Zmijewski JW, 2008, AM J RESP CRIT CARE, V178, P168, DOI 10.1164/rccm.200710-1602OC
   Zumla A, 2020, INT J INFECT DIS, V96, P431, DOI 10.1016/j.ijid.2020.05.040
NR 168
TC 17
Z9 17
U1 3
U2 11
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 2509-2715
EI 2509-2723
J9 GEROSCIENCE
JI GeroScience
PD JUN
PY 2021
VL 43
IS 3
SI SI
BP 1093
EP 1112
DI 10.1007/s11357-020-00261-6
EA SEP 2020
PG 20
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA SQ7HY
UT WOS:000567721900002
PM 32902818
OA Bronze, Green Published
DA 2023-06-08
ER

PT J
AU Wu, H
   Esteve, E
   Tremaroli, V
   Khan, MT
   Caesar, R
   Manneras-Holm, L
   Stahlman, M
   Olsson, LM
   Serino, M
   Planas-Felix, M
   Xifra, G
   Mercader, JM
   Torrents, D
   Burcelin, R
   Ricart, W
   Perkins, R
   Fernandez-Real, JM
   Backhed, F
AF Wu, Hao
   Esteve, Eduardo
   Tremaroli, Valentina
   Khan, Muhammad Tanweer
   Caesar, Robert
   Manneras-Holm, Louise
   Stahlman, Marcus
   Olsson, Lisa M.
   Serino, Matteo
   Planas-Felix, Mercs
   Xifra, Gemma
   Mercader, Josep M.
   Torrents, David
   Burcelin, Remy
   Ricart, Wifredo
   Perkins, Rosie
   Fernandez-Real, Jose Manuel
   Backhed, Fredrik
TI Metformin alters the gut microbiome of individuals with treatment-naive
   type 2 diabetes, contributing to the therapeutic effects of the drug
SO NATURE MEDICINE
LA English
DT Article
ID DIET-INDUCED OBESITY; AKKERMANSIA-MUCINIPHILA; GLUCOSE-HOMEOSTASIS;
   BACTERIAL; GLUCONEOGENESIS; ASSOCIATION; MODULATION; EXTRACTION;
   RESISTANCE; POPULATION
AB Metformin is widely used in the treatment of type 2 diabetes (T2D), but its mechanism of action is poorly defined. Recent evidence implicates the gut microbiota as a site of metformin action. In a double-blind study, we randomized individuals with treatment-naive T2D to placebo or metformin for 4 months and showed that metformin had strong effects on the gut microbiome. These results were verified in a subset of the placebo group that switched to metformin 6 months after the start of the trial. Transfer of fecal samples (obtained before and 4 months after treatment) from metformin-treated donors to germ-free mice showed that glucose tolerance was improved in mice that received metformin-altered microbiota. By directly investigating metformin-microbiota interactions in a gut simulator, we showed that metformin affected pathways with common biological functions in species from two different phyla, and many of the metformin-regulated genes in these species encoded metalloproteins or metal transporters. Our findings provide support for the notion that altered gut microbiota mediates some of metformin's antidiabetic effects.
C1 [Wu, Hao; Tremaroli, Valentina; Khan, Muhammad Tanweer; Caesar, Robert; Manneras-Holm, Louise; Stahlman, Marcus; Olsson, Lisa M.; Perkins, Rosie; Backhed, Fredrik] Univ Gothenburg, Inst Med, Dept Mol & Clin Med, Wallenberg Lab, Gothenburg, Sweden.
   [Esteve, Eduardo; Xifra, Gemma; Ricart, Wifredo; Fernandez-Real, Jose Manuel] Hosp Josep Trueta, Inst Invest Biomed Girona, Dept Diabet Endocrinol & Nutr, Girona, Spain.
   [Esteve, Eduardo; Xifra, Gemma; Ricart, Wifredo; Fernandez-Real, Jose Manuel] Univ Girona, Fac Med, Dept Med, Girona, Spain.
   [Esteve, Eduardo; Xifra, Gemma; Ricart, Wifredo; Fernandez-Real, Jose Manuel] Inst Salud Carlos III, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Madrid, Spain.
   [Serino, Matteo] Univ Toulouse, IRSD, INSERM, INRA,ENVT,UPS, Toulouse, France.
   [Planas-Felix, Mercs; Mercader, Josep M.; Torrents, David] BSC, Joint BSC CRG IRB Res Program Computat Biol, Barcelona, Spain.
   [Torrents, David] ICREA, Barcelona, Spain.
   [Burcelin, Remy] INSERM, Toulouse, France.
   [Burcelin, Remy] UPS, UMR 1048, Inst Malad Metab & Cardiovasc, Toulouse, France.
   [Backhed, Fredrik] Sahlgrens Univ Hosp, Gothenburg, Sweden.
   [Backhed, Fredrik] Univ Copenhagen, Fac Hlth Sci, Sect Metab Receptol & Enteroendocrinol, Novo Nordisk Fdn,Ctr Basic Metab Res, Copenhagen, Denmark.
C3 University of Gothenburg; Universitat de Girona; Girona University
   Hospital Dr. Josep Trueta; Institut d'Investigacio Biomedica de Girona
   (IDIBGI); Universitat de Girona; CIBER - Centro de Investigacion
   Biomedica en Red; CIBEROBN; Instituto de Salud Carlos III; INRAE;
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite de Toulouse; Ecole Nationale Veterinaire de Toulouse;
   Universite Toulouse III - Paul Sabatier; Barcelona Institute of Science
   & Technology; Institute for Research in Biomedicine - IRB Barcelona;
   ICREA; Institut National de la Sante et de la Recherche Medicale
   (Inserm); Universite de Toulouse; Universite Toulouse III - Paul
   Sabatier; Sahlgrenska University Hospital; Novo Nordisk Foundation;
   University of Copenhagen
RP Backhed, F (通讯作者)，Univ Gothenburg, Inst Med, Dept Mol & Clin Med, Wallenberg Lab, Gothenburg, Sweden.; Fernandez-Real, JM (通讯作者)，Hosp Josep Trueta, Inst Invest Biomed Girona, Dept Diabet Endocrinol & Nutr, Girona, Spain.; Fernandez-Real, JM (通讯作者)，Univ Girona, Fac Med, Dept Med, Girona, Spain.; Fernandez-Real, JM (通讯作者)，Inst Salud Carlos III, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Madrid, Spain.; Backhed, F (通讯作者)，Sahlgrens Univ Hosp, Gothenburg, Sweden.; Backhed, F (通讯作者)，Univ Copenhagen, Fac Hlth Sci, Sect Metab Receptol & Enteroendocrinol, Novo Nordisk Fdn,Ctr Basic Metab Res, Copenhagen, Denmark.
EM jmfreal@idibgi.org; fredrik.backhed@wlab.gu.se
RI Serino, Matteo/O-3310-2018; StÃhlman, Marcus/M-4597-2019; burcelin,
   remy/M-6013-2014; Caesar, Robert/AAX-3205-2020; Torrents,
   David/G-5785-2015; Tremaroli, Valentina/AAE-8001-2019; Fernández-Real,
   Jose Manuel/AGH-3599-2022; Backhed, Fredrik/ABE-6613-2020
OI Serino, Matteo/0000-0003-4644-8532; Torrents, David/0000-0002-6086-9037;
   Tremaroli, Valentina/0000-0002-9150-4233; Fernández-Real, Jose
   Manuel/0000-0002-7442-9323; Backhed, Fredrik/0000-0002-4871-8818;
   Mercader, Josep M/0000-0001-8494-3660; Planas-Felix,
   Merce/0000-0002-8267-576X; Wu, Hao/0000-0003-1314-4954; Henricsson,
   Marcus/0000-0002-4202-0339
FU Swedish Diabetes Foundation; Swedish Research Council; Swedish Heart
   Lung Foundation; Torsten Soderberg's Foundation; Goran Gustafsson's
   Foundation; Inga Britt and Arne Lundberg's Foundation; Swedish
   Foundation for Strategic Research; Knut and Alice Wallenberg Foundation;
   Novo Nordisk Foundation; Region Vastra Gotaland; Sahlgrenska University
   Hospital; Ministerio de Economia y Competitividad [PI11-00214,
   PI15/01934]; FEDER funds; Obra Social Fundacion la Caixa fellowship
   under the Severo Ochoa program; Sara Borrell Fellowship from the
   Instituto Carlos III; EFSD/Lilly Research Fellowship; Beatriu de Pinos
   Fellowship from the Agency for Management of University and Research
   Grants (AGAUR); ERC Consolidator Grant (European Research Council)
   [615362-METABASE]; NNF Center for Basic Metabolic Research [Bäckhed
   Group] Funding Source: researchfish; Novo Nordisk Fonden
   [NNF15OC0016798, NNF13OC0008163] Funding Source: researchfish
FX We thank C. Arvidsson, S. Nordin-Larsson, C. Wennberg, and U. Enqvist
   for superb mouse husbandry. The administrative and technical help of
   J.M. Moreno Navarrete, E. Huertos, M. Sabater, and O. Rovira is also
   acknowledged. The strain Akkermansia muciniphila DSM22959 was kindly
   provided by W. de Vos (Wageningen University and Helsinki University).
   The strain Bifidobacterium adolescentis L2-32 was kindly provided by K.
   Scott (The Rowett Institute of Nutrition and Health, University of
   Aberdeen). Whole-genome shotgun sequencing was performed at the Genomics
   Core Facility at the Sahlgrenska Academy, University of Gothenburg. The
   computations for metagenomics analyses were performed on resources
   provided by the Swedish National Infrastructure for Computing (SNIC)
   through Uppsala Multidisciplinary Center for Advanced Computational
   Science (UPPMAX). This study was supported by the Swedish Diabetes
   Foundation; Swedish Research Council; Swedish Heart Lung Foundation;
   Torsten Soderberg's Foundation; Goran Gustafsson's Foundation; Inga
   Britt and Arne Lundberg's Foundation; Swedish Foundation for Strategic
   Research; Knut and Alice Wallenberg Foundation; the Novo Nordisk
   Foundation; the regional agreement on medical training and clinical
   research (ALF) between Region Vastra Gotaland and Sahlgrenska University
   Hospital; the Ministerio de Economia y Competitividad (PI11-00214 and
   PI15/01934); and FEDER funds. CIBEROBN Fisiopatologia de la Obesidad y
   Nutricion is an initiative from the Instituto de Salud Carlos III from
   Spain. M.P.-F. is funded by the Obra Social Fundacion la Caixa
   fellowship under the Severo Ochoa 2013 program. J. M. M. was supported
   by the Sara Borrell Fellowship from the Instituto Carlos III, EFSD/Lilly
   Research Fellowship and Beatriu de Pinos Fellowship from the Agency for
   Management of University and Research Grants (AGAUR). F.B. is a
   recipient of ERC Consolidator Grant (European Research Council,
   Consolidator grant 615362-METABASE).
CR ALTSCHUL SF, 1990, J MOL BIOL, V215, P403, DOI 10.1006/jmbi.1990.9999
   Amer Diabet Assoc, 2010, DIABETES CARE, V33, pS62, DOI 10.2337/dc10-s062
   Anhe FF, 2015, GUT, V64, P872, DOI 10.1136/gutjnl-2014-307142
   Backhed F, 2007, P NATL ACAD SCI USA, V104, P979, DOI 10.1073/pnas.0605374104
   BENJAMINI Y, 1995, J R STAT SOC B, V57, P289, DOI 10.1111/j.2517-6161.1995.tb02031.x
   Buse JB, 2016, DIABETES CARE, V39, P198, DOI 10.2337/dc15-0488
   CASPARY WF, 1977, DIABETOLOGIA, V13, P187, DOI 10.1007/BF01219698
   Chen JJ, 2012, BRIT J NUTR, V107, P1429, DOI 10.1017/S0007114511004491
   Collado MC, 2007, APPL ENVIRON MICROB, V73, P7767, DOI 10.1128/AEM.01477-07
   Cotillard A, 2013, NATURE, V500, P585, DOI 10.1038/nature12480
   Csardi G., 2006, INT J COMPLEX SYST, V1695, P1, DOI DOI 10.3724/SP.J.1087.2009.02191
   Dao MC, 2016, GUT, V65, P426, DOI 10.1136/gutjnl-2014-308778
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   De Vadder F, 2016, CELL METAB, V24, P151, DOI 10.1016/j.cmet.2016.06.013
   Desai MS, 2016, CELL, V167, P1339, DOI 10.1016/j.cell.2016.10.043
   Duca FA, 2015, NAT MED, V21, P506, DOI 10.1038/nm.3787
   Everard A, 2014, ISME J, V8, P2116, DOI 10.1038/ismej.2014.45
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Foretz M, 2010, J CLIN INVEST, V120, P2355, DOI 10.1172/JCI40671
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Franceschini A, 2013, NUCLEIC ACIDS RES, V41, pD808, DOI 10.1093/nar/gks1094
   Fullerton MD, 2013, NAT MED, V19, P1649, DOI 10.1038/nm.3372
   Greer RL, 2016, NAT COMMUN, V7, DOI 10.1038/ncomms13329
   Gu ZG, 2014, BIOINFORMATICS, V30, P2811, DOI 10.1093/bioinformatics/btu393
   Kanehisa M, 2000, NUCLEIC ACIDS RES, V28, P27, DOI 10.1093/nar/28.1.27
   Karlsson FH, 2014, PLOS COMPUT BIOL, V10, DOI 10.1371/journal.pcbi.1003706
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kindt R., 2005, TREE DIVERSITY ANAL
   Koh A, 2016, CELL, V165, P1332, DOI 10.1016/j.cell.2016.05.041
   Kong FL, 2016, CURR BIOL, V26, pR832, DOI 10.1016/j.cub.2016.08.015
   Korem T, 2015, SCIENCE, V349, P1101, DOI 10.1126/science.aac4812
   Langmead B, 2012, NAT METHODS, V9, P357, DOI [10.1038/NMETH.1923, 10.1038/nmeth.1923]
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Lee YS, 2016, MOL METAB, V5, P263, DOI 10.1016/j.molmet.2016.01.007
   Leucht S, 2015, BMC MED, V13, DOI 10.1186/s12916-015-0494-1
   Li JH, 2014, NAT BIOTECHNOL, V32, P834, DOI 10.1038/nbt.2942
   Logie L, 2012, DIABETES, V61, P1423, DOI 10.2337/db11-0961
   Love MI, 2014, GENOME BIOL, V15, DOI 10.1186/s13059-014-0550-8
   Madiraju AK, 2014, NATURE, V510, P542, DOI 10.1038/nature13270
   Fernandez-Real JM, 2014, LANCET DIABETES ENDO, V2, P513, DOI 10.1016/S2213-8587(13)70174-8
   McCreight LJ, 2016, DIABETOLOGIA, V59, P426, DOI 10.1007/s00125-015-3844-9
   McMurdie PJ, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0061217
   Miller RA, 2013, NATURE, V494, P256, DOI 10.1038/nature11808
   Murphy NR, 1996, BIOTECHNIQUES, V21, P934
   Nathan DM, 2009, DIABETES CARE, V32, P193, DOI 10.2337/dc08-9025
   Park SK, 2012, INT J SYST EVOL MICR, V62, P776, DOI 10.1099/ijs.0.031625-0
   Pernicova I, 2014, NAT REV ENDOCRINOL, V10, P143, DOI 10.1038/nrendo.2013.256
   Plovier H, 2017, NAT MED, V23, P107, DOI 10.1038/nm.4236
   Ridlon JM, 2016, GUT MICROBES, V7, P22, DOI 10.1080/19490976.2015.1127483
   Roopchand DE, 2015, DIABETES, V64, P2847, DOI 10.2337/db14-1916
   Salonen A, 2010, J MICROBIOL METH, V81, P127, DOI 10.1016/j.mimet.2010.02.007
   Scarpello JHB, 1998, DIABETIC MED, V15, P651, DOI 10.1002/(SICI)1096-9136(199808)15:8<651::AID-DIA628>3.0.CO;2-A
   Schaap FG, 2014, NAT REV GASTRO HEPAT, V11, P55, DOI 10.1038/nrgastro.2013.151
   Shaw RJ, 2005, SCIENCE, V310, P1642, DOI 10.1126/science.1120781
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Stepensky D, 2002, DRUG METAB DISPOS, V30, P861, DOI 10.1124/dmd.30.8.861
   Tatusova T, 2014, NUCLEIC ACIDS RES, V42, pD553, DOI 10.1093/nar/gkt1274
   Team R. C. R, 2015, LANG ENV STAT COMP
   Tremaroli V, 2015, CELL METAB, V22, P228, DOI 10.1016/j.cmet.2015.07.009
   Van den Abbeele P, 2010, APPL ENVIRON MICROB, V76, P5237, DOI 10.1128/AEM.00759-10
   Vioque J, 2013, NUTR J, V12, DOI 10.1186/1475-2891-12-26
   Wahlstrom A, 2017, J LIPID RES, V58, P412, DOI 10.1194/jlr.M072819
   Wahlstrom A, 2016, CELL METAB, V24, P41, DOI 10.1016/j.cmet.2016.05.005
   Wichmann A, 2013, CELL HOST MICROBE, V14, P582, DOI 10.1016/j.chom.2013.09.012
   Wong JMW, 2006, J CLIN GASTROENTEROL, V40, P235, DOI 10.1097/00004836-200603000-00015
   Young MD, 2010, GENOME BIOL, V11, DOI 10.1186/gb-2010-11-2-r14
   Zhang HS, 2015, ISME J, V9, P770, DOI 10.1038/ismej.2014.165
   Zhang X, 2015, SCI REP-UK, V5, DOI 10.1038/srep14405
   Zhernakova A, 2016, SCIENCE, V352, P565, DOI 10.1126/science.aad3369
   Zhou GC, 2001, J CLIN INVEST, V108, P1167, DOI 10.1172/JCI200113505
   Zoetendal EG, 2006, NAT PROTOC, V1, P954, DOI 10.1038/nprot.2006.143
NR 71
TC 860
Z9 910
U1 18
U2 449
PU NATURE RESEARCH
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 1078-8956
EI 1546-170X
J9 NAT MED
JI Nat. Med.
PD JUL
PY 2017
VL 23
IS 7
BP 850
EP +
DI 10.1038/nm.4345
PG 12
WC Biochemistry & Molecular Biology; Cell Biology; Medicine, Research &
   Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology; Research & Experimental
   Medicine
GA FA1DS
UT WOS:000405180100014
PM 28530702
HC Y
HP N
DA 2023-06-08
ER

PT J
AU Lee, H
   Ko, G
AF Lee, Heetae
   Ko, GwangPyo
TI Effect of Metformin on Metabolic Improvement and Gut Microbiota
SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY
LA English
DT Article
ID ACTIVATED PROTEIN-KINASE; AKKERMANSIA-MUCINIPHILA; GENDER-DIFFERENCES;
   ENERGY; ASSOCIATION; LIFE
AB Metformin is commonly used as the first line of medication for the treatment of metabolic syndromes, such as obesity and type 2 diabetes (T2D). Recently, metformin-induced changes in the gut microbiota have been reported; however, the relationship between metformin treatment and the gut microbiota remains unclear. In this study, the composition of the gut microbiota was investigated using a mouse model of high-fat-diet (HFD)-induced obesity with and without metformin treatment. As expected, metformin treatment improved markers of metabolic disorders, including serum glucose levels, body weight, and total cholesterol levels. Moreover, Akkermansia muciniphila (12.44% +/- 5.26%) and Clostridium cocleatum (0.10% +/- 0.09%) abundances increased significantly after metformin treatment of mice on the HFD. The relative abundance of A. muciniphila in the fecal microbiota was also found to increase in brain heart infusion (BHI) medium supplemented with metformin in vitro. In addition to the changes in the microbiota associated with metformin treatment, when other influences were controlled for, a total of 18 KEGG metabolic pathways (including those for sphingolipid and fatty acid metabolism) were significantly upregulated in the gut microbiota during metformin treatment of mice on an HFD. Our results demonstrate that the gut microbiota and their metabolic pathways are influenced by metformin treatment.
C1 [Lee, Heetae; Ko, GwangPyo] Seoul Natl Univ, Sch Publ Hlth, Ctr Human & Environm Microbiome, Seoul, South Korea.
   [Ko, GwangPyo] Seoul Natl Univ, N Bio, Seoul, South Korea.
C3 Seoul National University (SNU); Seoul National University (SNU)
RP Ko, G (通讯作者)，Seoul Natl Univ, Sch Publ Hlth, Ctr Human & Environm Microbiome, Seoul, South Korea.
EM gko@snu.ac.kr
FU National Research Foundation of Korea (NRF) - South Korea government
   (MEST) [2012-0008692]; National Research Foundation of Korea
   [2010-0029113, 22A20130012682] Funding Source: Korea Institute of
   Science & Technology Information (KISTI), National Science & Technology
   Information Service (NTIS)
FX This study was supported by a grant from the National Research
   Foundation of Korea (NRF) funded by the South Korea government (MEST)
   (2012-0008692).
CR Anisimov VN, 2010, AGING-US, V2, P945, DOI 10.18632/aging.100245
   Bikman BT, 2011, J CLIN INVEST, V121, P4222, DOI 10.1172/JCI57144
   Caporaso JG, 2010, NAT METHODS, V7, P335, DOI 10.1038/nmeth.f.303
   Chavez JA, 2005, J BIOL CHEM, V280, P20148, DOI 10.1074/jbc.M412769200
   Collado MC, 2007, APPL ENVIRON MICROB, V73, P7767, DOI 10.1128/AEM.01477-07
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Foretz M, 2010, J CLIN INVEST, V120, P2355, DOI 10.1172/JCI40671
   Frank DN, 2007, P NATL ACAD SCI USA, V104, P13780, DOI 10.1073/pnas.0706625104
   Geer EB, 2009, GENDER MED, V6, P60, DOI 10.1016/j.genm.2009.02.002
   Gove ME, 2009, J LEUKOCYTE BIOL, V85, P491, DOI 10.1189/jlb.0808508
   Gui YT, 2004, OBES RES, V12, P1481, DOI 10.1038/oby.2004.185
   Hardie DG, 2012, NAT REV MOL CELL BIO, V13, P251, DOI 10.1038/nrm3311
   Hla T, 2012, CELL METAB, V16, P420, DOI 10.1016/j.cmet.2012.06.017
   HOSKINS LC, 1981, J CLIN INVEST, V67, P163, DOI 10.1172/JCI110009
   Kim SH, 2012, KOREAN J ORTHOD, V42, P55, DOI 10.4041/kjod.2012.42.2.55
   Kirpichnikov D, 2002, ANN INTERN MED, V137, P25, DOI 10.7326/0003-4819-137-1-200207020-00009
   Lee JE, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0063514
   Ley RE, 2005, P NATL ACAD SCI USA, V102, P11070, DOI 10.1073/pnas.0504978102
   Malinen E, 2010, WORLD J GASTROENTERO, V16, P4532, DOI 10.3748/wjg.v16.i36.4532
   Malkki H, 2014, NAT REV NEUROL, V10, P243, DOI [10.1038/nrneurol.2014.63, 10.1038/nrneurol.2013.250, 10.1038/nrneurol.2014.21, 10.1038/nrneurol.2014.168, 10.1038/nrneurol.2014.209, 10.1038/nrneurol.2013.267, 10.1038/nrneurol.2014.61, 10.1038/nrneurol.2014.142]
   Miller RA, 2013, NATURE, V494, P256, DOI 10.1038/nature11808
   Ordovas JM, 2006, CURR OPIN LIPIDOL, V17, P157, DOI 10.1097/01.mol.0000217897.75068.ba
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Rotella CM, 2006, CURR DIABETES REV, V2, P307, DOI 10.2174/157339906777950651
   SALYERS AA, 1977, APPL ENVIRON MICROB, V34, P529, DOI 10.1128/AEM.34.5.529-533.1977
   Segata N, 2011, GENOME BIOL, V12, DOI 10.1186/gb-2011-12-6-r60
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Viollet B, 2009, ACTA PHYSIOL, V196, P81, DOI 10.1111/j.1748-1716.2009.01970.x
   Wu BN, 2011, J NUTR METAB, V2011, DOI 10.1155/2011/391809
   Zhang L, 2007, AM J PHYSIOL-HEART C, V293, pH457, DOI 10.1152/ajpheart.00002.2007
NR 31
TC 258
Z9 275
U1 3
U2 81
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0099-2240
EI 1098-5336
J9 APPL ENVIRON MICROB
JI Appl. Environ. Microbiol.
PD OCT
PY 2014
VL 80
IS 19
BP 5935
EP 5943
DI 10.1128/AEM.01357-14
PG 9
WC Biotechnology & Applied Microbiology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Microbiology
GA AP2FD
UT WOS:000341887100007
PM 25038099
OA Green Published, Bronze
DA 2023-06-08
ER

PT J
AU Hu, N
   Zhang, Q
   Wang, H
   Yang, XP
   Jiang, Y
   Chen, R
   Wang, LY
AF Hu, Nan
   Zhang, Qi
   Wang, Hui
   Yang, Xuping
   Jiang, Yan
   Chen, Rong
   Wang, Liying
TI Comparative Evaluation of the Effect of Metformin and Insulin on Gut
   Microbiota and Metabolome Profiles of Type 2 Diabetic Rats Induced by
   the Combination of Streptozotocin and High-Fat Diet
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE type 2 diabetes; metformin; insulin; microbiota; metabolome; bile acids
ID AMINO-ACIDS; OBESITY; RESISTANCE; IDENTIFICATION; ACYLCARNITINES;
   INDIVIDUALS; SIGNATURES; MELLITUS
AB Lately, an increasing number of studies have investigated the relationship between metformin and gut microbiota, suggesting that metformin exerts part of its hypoglycemic effect through the microbes. However, its underlying mechanism remains largely undetermined. In the present study, we investigated the effects of metformin on gut microbiota and metabolome profiles in serum and compared it with insulin treatment in rats with type 2 diabetes mellitus (T2DM). Diabetic rats (DM group) were induced by a combination of streptozotocin and high-fat diet (HFD). After 7 days, DM rats were treated with metformin (MET group) or insulin (INS group) for 3 weeks. The 16S rRNA sequencing of the gut microbiota and non-targeted metabolomics analysis of serum were conducted. A total of 13 bile acids (BAs) in serum were further determined and compared among different groups. The rat model of T2DM was well established with the typical diabetic symptoms, showing significantly increased blood glucose, AUC of OGTT, HOMA-IR, TC, TG, LDL-C and TBA. Metformin or insulin treatment could ameliorate symptoms of diabetes and partly recover the abnormal biochemical indicators. Compared with DM rats, the relative abundances of 13 genera were significantly changed after metformin treatment, while only three genera were changed after insulin treatment. The metformin and insulin treatments also exhibited different serum metabolome profiles in T2DM rats. Moreover, 64 differential metabolites were identified between MET and DM groups, whereas 206 were identified between INS and DM groups. Insulin treatment showed greater influence on amino acids, glycerophospholipids/glycerolipids, and acylcarnitine compared with the metformin treatment, while metformin had an important impact on BAs. Furthermore, metformin could significantly decrease the serum levels of CA, GCA, UDCA, and GUDCA, but increase the level of TLCA in DM rats. Insulin treatment significantly decreased the levels of CA, UDCA, and CDCA. Besides, several metabolites in serum or microbiota were positively or negatively correlated with some bacteria. Collectively, our findings indicated that metformin had a stronger effect on gut microbiota than insulin, while insulin treatment showed greater influence on serum metabolites, which provided novel insights into the therapeutic effects of metformin on diabetes.
C1 [Hu, Nan; Yang, Xuping; Jiang, Yan; Chen, Rong; Wang, Liying] Soochow Univ, Peoples Hosp Changzhou 1, Affiliated Hosp 3, Dept Pharm, Changzhou, Jiangsu, Peoples R China.
   [Zhang, Qi] Changzhou No 7 Peoples Hosp, Dept Pharm, Changzhou, Jiangsu, Peoples R China.
   [Wang, Hui] Soochow Univ, Peoples Hosp Changzhou 1, Affiliated Hosp 3, Dept Pathol, Changzhou, Jiangsu, Peoples R China.
C3 Soochow University - China; Soochow University - China
RP Chen, R; Wang, LY (通讯作者)，Soochow Univ, Peoples Hosp Changzhou 1, Affiliated Hosp 3, Dept Pharm, Changzhou, Jiangsu, Peoples R China.
EM pharmacy_czyy@163.com; wlyzqcz@163.com
FU National Natural Science Foundation of China [81503136]; Changzhou High
   Level Medical Talents Training Project [2016CZBJ010]; Science and
   Technology Project of Changzhou Health Commission [QN 202005]
FX Funding This work was funded by National Natural Science Foundation of
   China (No. 81503136), Changzhou High Level Medical Talents Training
   Project (No. 2016CZBJ010), and Science and Technology Project of
   Changzhou Health Commission (QN 202005).
CR Adam J, 2016, DIABETES, V65, P3776, DOI 10.2337/db16-0512
   Ahmadi S, 2020, J GERONTOL A-BIOL, V75, pE9, DOI 10.1093/gerona/glaa056
   Barrett HL, 2018, NUTRIENTS, V10, DOI 10.3390/nu10070890
   Bloomgarden Z, 2018, J DIABETES, V10, P350, DOI 10.1111/1753-0407.12645
   Bornstein S, 2017, ENDOCRINOLOGY, V158, P3369, DOI 10.1210/en.2017-00299
   Carter D, 2003, DIABETES OBES METAB, V5, P120, DOI 10.1046/j.1463-1326.2003.00252.x
   Chen C, 2016, J PHARMACEUT BIOMED, V131, P473, DOI 10.1016/j.jpba.2016.09.023
   Cui HX, 2019, FRONT MICROBIOL, V10, DOI 10.3389/fmicb.2019.01423
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Elbere I, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0241338
   Everard A, 2013, BEST PRACT RES CL GA, V27, P73, DOI 10.1016/j.bpg.2013.03.007
   Ferrell JM, 2019, DIABETES METAB J, V43, P257, DOI 10.4093/dmj.2019.0043
   Floegel A, 2013, DIABETES, V62, P639, DOI 10.2337/db12-0495
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Gil-Gomez A, 2018, REV ESP ENFERM DIG, V110, P427, DOI 10.17235/reed.2018.5004/2017
   Gurung M, 2020, EBIOMEDICINE, V51, DOI 10.1016/j.ebiom.2019.11.051
   He L, 2020, TRENDS PHARMACOL SCI, V41, P868, DOI 10.1016/j.tips.2020.09.001
   Hiel S, 2020, CLIN NUTR, V39, P3618, DOI 10.1016/j.clnu.2020.04.005
   Hu N, 2021, EUR J PHARM SCI, V162, DOI 10.1016/j.ejps.2021.105833
   Irving BA, 2016, DIABETES, V65, P3537, DOI 10.2337/dbi16-0050
   Irving BA, 2015, METABOLISM, V64, P720, DOI 10.1016/j.metabol.2015.01.008
   Knebel B, 2016, J CLIN ENDOCR METAB, V101, P2130, DOI 10.1210/jc.2015-4133
   Kristofi R, 2021, J ENDOCRINOL, V251, pR11, DOI 10.1530/JOE-21-0194
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Lee H, 2018, GUT MICROBES, V9, P155, DOI 10.1080/19490976.2017.1405209
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Li AL, 2021, J FOOD BIOCHEM, V45, DOI 10.1111/jfbc.13541
   Liu Q, 2020, LIFE SCI, V261, DOI 10.1016/j.lfs.2020.118457
   Louis P, 2004, J BACTERIOL, V186, P2099, DOI 10.1128/JB.186.7.2099-2106.2004
   Makarova E, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00870
   Meikle PJ, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0074341
   Mihalik SJ, 2010, OBESITY, V18, P1695, DOI 10.1038/oby.2009.510
   Muoio DM, 2012, CELL METAB, V15, P595, DOI 10.1016/j.cmet.2012.04.010
   Ramos-Roman MA, 2012, METABOLISM, V61, P202, DOI 10.1016/j.metabol.2011.06.008
   Reichardt N, 2014, ISME J, V8, P1323, DOI 10.1038/ismej.2014.14
   Rotroff DM, 2016, FRONT PHARMACOL, V7, DOI 10.3389/fphar.2016.00135
   Ryan PM, 2020, CAN J DIABETES, V44, P146, DOI 10.1016/j.jcjd.2019.05.008
   Safai N, 2018, DIABETIC MED, V35, P944, DOI 10.1111/dme.13636
   Schooneman MG, 2013, DIABETES, V62, P1, DOI 10.2337/db12-0466
   Schutz Y, 2011, INT J VITAM NUTR RES, V81, P101, DOI 10.1024/0300-9831/a000064
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Shui GH, 2013, METABOLOMICS, V9, P786, DOI 10.1007/s11306-013-0494-0
   Sonne DP, 2016, J CLIN ENDOCR METAB, V101, P3002, DOI 10.1210/jc.2016-1607
   Tai ES, 2010, DIABETOLOGIA, V53, P757, DOI 10.1007/s00125-009-1637-8
   Tonks KT, 2016, OBESITY, V24, P908, DOI 10.1002/oby.21448
   Viollet B, 2012, CLIN SCI, V122, P253, DOI 10.1042/CS20110386
   Wang ZJ, 2019, DRUG METAB DISPOS, V47, P1066, DOI 10.1124/dmd.118.085902
   Wanninger J, 2008, BBA-MOL CELL BIOL L, V1781, P321, DOI 10.1016/j.bbalip.2008.04.012
   White PJ, 2021, MOL METAB, V52, DOI 10.1016/j.molmet.2021.101261
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Zhang FH, 2019, ENDOCRINE, V66, P485, DOI 10.1007/s12020-019-02041-5
   Zhang MC, 2019, BMJ OPEN DIAB RES CA, V7, DOI 10.1136/bmjdrc-2019-000717
   Zhang Q, 2020, DIABET METAB SYND OB, V13, P5003, DOI 10.2147/DMSO.S286430
   Zhang W, 2019, BIOMED PHARMACOTHER, V118, DOI 10.1016/j.biopha.2019.109131
   Zhang X, 2015, SCI REP-UK, V5, DOI 10.1038/srep14405
   Zhao C, 2013, BMC MED GENOMICS, V6, DOI 10.1186/1755-8794-6-S1-S12
   Zhu C, 2011, TALANTA, V85, P1711, DOI 10.1016/j.talanta.2011.05.036
NR 57
TC 6
Z9 6
U1 3
U2 8
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD JAN 3
PY 2022
VL 12
AR 794103
DI 10.3389/fphar.2021.794103
PG 18
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA YK3QW
UT WOS:000745132800001
PM 35046817
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Guo, XX
   Wang, C
   Zhang, RR
   Hao, XL
   Lv, L
   Ni, Y
   Fan, XH
   Zhang, WL
   Jiao, YH
   Song, W
   Dong, Q
   Qi, YQ
   Song, MQ
   Qin, XM
AF Guo, Xiaoxia
   Wang, Chong
   Zhang, Ranran
   Hao, Xuliang
   Lv, Lei
   Ni, Yan
   Fan, Xiaohong
   Zhang, Weiliang
   Jiao, Yunhong
   Song, Wei
   Dong, Qi
   Qi, Yuqi
   Song, Meiqing
   Qin, Xuemei
TI Scrophulariae Radix-Atractylodes sinensis pair and metformin inhibit
   inflammation by modulating gut microbiota of high-fat
   diet/streptozotocin-induced diabetes in rats
SO FRONTIERS IN MICROBIOLOGY
LA English
DT Article
DE type 2 diabetes mellitus; Scrophulariae Radix; Atractylodes sinensis
   pair; metformin; gut microbiota
ID GLUCOSE-METABOLISM; OBESITY; DIET; INDIVIDUALS; DATABASE; SEARCH
AB IntroductionType 2 mellitus (T2DM), a chronic metabolic disorder, causes severe impairment of patients' quality of life and has attracted global attention. Many studies have suggested the importance of the gut microbiota in the occurrence of T2DM. The Scrophulariae Radix and Atractylodes sinensis (XC) pair, recommended in traditional Chinese medicine (TCM), have been used for treating diabetes for many years. However, research on the role of the XC pair in modulating gut microbial communities is lacking, but it is important to elucidate the underlying mechanism. MethodsIn this study, we detected bacterial communities by high-throughput 16S rRNA gene sequencing. ResultsThe results showed that XC + MET reduced postprandial hyperglycemia and inflammatory response in diabetic rats more effectively than metformin (MET) alone. The XC + MET treatment reshaped the intestinal microbial composition of diabetic rats. XC can help MET regulate carbohydrate, amino acid, and lipid metabolism, particularly the insulin signaling pathway. DiscussionThis research would help elucidate potential mechanisms and the treatment methods.
C1 [Guo, Xiaoxia; Wang, Chong; Zhang, Ranran; Lv, Lei; Ni, Yan; Fan, Xiaohong; Zhang, Weiliang; Jiao, Yunhong; Song, Wei; Dong, Qi; Qi, Yuqi] Shanxi Inst Tradit Chinese Med, Dept Metab, Taiyuan, Shanxi, Peoples R China.
   [Hao, Xuliang] Shanxi Univ Chinese Med, Tradit Chinese Med Preparat Ctr, Affiliated Hosp, Taiyuan, Shanxi, Peoples R China.
   [Song, Meiqing] Shanxi Inst Tradit Chinese Med, Clin Pharmacol Res Lab, Taiyuan, Shanxi, Peoples R China.
   [Qin, Xuemei] Shanxi Univ, Modern Res Ctr Tradit Chinese Med, Taiyuan, Shanxi, Peoples R China.
C3 Shanxi University of Chinese Medicine; Shanxi University
RP Hao, XL (通讯作者)，Shanxi Univ Chinese Med, Tradit Chinese Med Preparat Ctr, Affiliated Hosp, Taiyuan, Shanxi, Peoples R China.
EM hxliang-01@163.com
RI Zhang, Ran/HTT-1545-2023
CR Altschul SF, 1997, NUCLEIC ACIDS RES, V25, P3389, DOI 10.1093/nar/25.17.3389
   Arya A, 2014, FOOD CHEM TOXICOL, V71, P183, DOI 10.1016/j.fct.2014.06.010
   Bakkar NMZ, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21239005
   Basevi V, 2011, DIABETES CARE, V34, P1887, DOI 10.2337/dc11-s011
   Benitez-Paez A, 2020, MSYSTEMS, V5, DOI 10.1128/mSystems.00857-19
   Boulange CL, 2016, GENOME MED, V8, DOI 10.1186/s13073-016-0303-2
   Cabreiro F, 2013, CELL, V153, P228, DOI 10.1016/j.cell.2013.02.035
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Caporaso JG, 2010, NAT METHODS, V7, P335, DOI 10.1038/nmeth.f.303
   Cherney DZI, 2018, CELL METAB, V28, P808, DOI 10.1016/j.cmet.2018.11.012
   Das AK, 2021, CLIN MED INSIGHTS-EN, V14, DOI 10.1177/11795514211030513
   De Filippis F, 2019, CELL HOST MICROBE, V25, P444, DOI 10.1016/j.chom.2019.01.004
   Deeds MC, 2011, LAB ANIM-UK, V45, P131, DOI 10.1258/la.2010.010090
   Del Chierico F, 2016, EXP PARASITOL, V170, P82, DOI 10.1016/j.exppara.2016.09.007
   DeSantis TZ, 2006, APPL ENVIRON MICROB, V72, P5069, DOI 10.1128/AEM.03006-05
   Dixit VD, 2013, DIABETES, V62, P22, DOI 10.2337/db12-1115
   Drzewoski J, 2021, PHARMACEUTICALS-BASE, V14, DOI 10.3390/ph14020122
   Duncan SH, 2008, INT J OBESITY, V32, P1720, DOI 10.1038/ijo.2008.155
   Edgar RC, 2010, BIOINFORMATICS, V26, P2460, DOI 10.1093/bioinformatics/btq461
   Egshatyan L, 2016, ENDOCR CONNECT, V5, P1, DOI 10.1530/EC-15-0094
   Eleazu C O, 2013, Int J Biomed Sci, V9, P82
   Furman Brian L, 2021, Curr Protoc, V1, pe78, DOI 10.1002/cpz1.78
   Gall WE, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0010883
   Guariguata L, 2014, DIABETES RES CLIN PR, V103, P137, DOI 10.1016/j.diabres.2013.11.002
   Guo GL, 2018, NAT MED, V24, P1789, DOI 10.1038/s41591-018-0273-6
   Kanehisa M, 2008, NUCLEIC ACIDS RES, V36, pD480, DOI 10.1093/nar/gkm882
   Kovatcheva-Datchary P, 2015, CELL METAB, V22, P971, DOI 10.1016/j.cmet.2015.10.001
   Kuno T, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-19545-1
   Langille MGI, 2013, NAT BIOTECHNOL, V31, P814, DOI 10.1038/nbt.2676
   Larsen JM, 2017, IMMUNOLOGY, V151, P363, DOI 10.1111/imm.12760
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Lee HJ, 2021, MOLECULES, V26, DOI 10.3390/molecules26175250
   Leustean AM, 2018, J DIABETES RES, V2018, DOI 10.1155/2018/5205126
   Ley RE, 2006, NATURE, V444, P1022, DOI 10.1038/4441022a
   Li XZ, 2014, SOIL BIOL BIOCHEM, V68, P392, DOI 10.1016/j.soilbio.2013.10.017
   Li YZ, 2020, BMJ-BRIT MED J, V369, DOI 10.1136/bmj.m997
   Lin CH, 2014, BRIT J NUTR, V111, P598, DOI 10.1017/S0007114513002791
   Ling ZX, 2014, SCI REP-UK, V4, DOI 10.1038/srep07485
   Magliano DJ, 2019, BMJ-BRIT MED J, V366, DOI 10.1136/bmj.l5003
   Mannucci E, 2012, ACTA DIABETOL, V49, P307, DOI 10.1007/s00592-011-0355-0
   Martin AM, 2019, P NATL ACAD SCI USA, V116, P19802, DOI 10.1073/pnas.1909311116
   Baena-Diez JM, 2016, DIABETES CARE, V39, P1987, DOI 10.2337/dc16-0614
   Mueller NT, 2021, DIABETES CARE, V44, P1462, DOI 10.2337/dc20-2257
   Nasri H, 2014, J RES MED SCI, V19, P658
   Nathan DM, 2015, JAMA-J AM MED ASSOC, V314, P1052, DOI 10.1001/jama.2015.9536
   Navab M, 2008, CURR OPIN CLIN NUTR, V11, P459, DOI 10.1097/MCO.0b013e32830460c2
   O'Keefe SJD, 2008, CURR OPIN GASTROEN, V24, P51, DOI 10.1097/MOG.0b013e3282f323f3
   Oliphant K, 2019, MICROBIOME, V7, DOI 10.1186/s40168-019-0704-8
   Ozato N, 2019, NPJ BIOFILMS MICROBI, V5, DOI 10.1038/s41522-019-0101-x
   Pang J, 2021, J ETHNOPHARMACOL, V281, DOI 10.1016/j.jep.2021.114026
   Pedersen HK, 2016, NATURE, V535, P376, DOI 10.1038/nature18646
   Pingitore A, 2017, DIABETES OBES METAB, V19, P257, DOI 10.1111/dom.12811
   Pryor R, 2019, CELL, V178, P1299, DOI 10.1016/j.cell.2019.08.003
   Rai RC, 2020, LIFE SCI, V253, DOI 10.1016/j.lfs.2020.117727
   Rajgopal RK, 2021, CURR DRUG SAF, V16, P165, DOI 10.2174/1574886315666210106142244
   Rodriguez J, 2020, GUT, V69, P1975, DOI 10.1136/gutjnl-2019-319726
   Saeedi P, 2020, DIABETES RES CLIN PR, V162, DOI 10.1016/j.diabres.2020.108086
   Schwiertz A, 2010, OBESITY, V18, P190, DOI 10.1038/oby.2009.167
   Segata N, 2011, GENOME BIOL, V12, DOI 10.1186/gb-2011-12-6-r60
   Seifarth C, 2013, EXP CLIN ENDOCR DIAB, V121, P27, DOI 10.1055/s-0032-1327734
   Sekhar RV, 2011, DIABETES CARE, V34, P162, DOI 10.2337/dc10-1006
   Sheu SY, 2015, BMC COMPLEM ALTERN M, V15, DOI 10.1186/s12906-015-0842-x
   Shin NR, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.02271
   Stienstra R, 2011, P NATL ACAD SCI USA, V108, P15324, DOI 10.1073/pnas.1100255108
   Strain WD, 2020, DIABETES THER, V11, P1381, DOI 10.1007/s13300-020-00834-w
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Tanca A, 2017, MICROBIOME, V5, DOI 10.1186/s40168-017-0293-3
   Tong XL, 2018, MBIO, V9, DOI 10.1128/mBio.02392-17
   Tseng CH, 2019, J FORMOS MED ASSOC, V118, pS3, DOI 10.1016/j.jfma.2018.07.009
   Vallianou NG, 2019, HORM-INT J ENDOCRINO, V18, P141, DOI 10.1007/s42000-019-00093-w
   van Olden C, 2015, CLIN THER, V37, P1172, DOI 10.1016/j.clinthera.2015.03.008
   Wan ZF, 2019, DIABETES METAB SYNDR, V12, P1931, DOI 10.2147/DMSO.S222053
   Wei XY, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-22094-2
   Wu LL, 2019, SAUDI J BIOL SCI, V26, P2096, DOI 10.1016/j.sjbs.2019.09.032
   Xiao Y, 2021, Nan Fang Yi Ke Da Xue Xue Bao, V41, P358, DOI 10.12122/j.issn.1673-4254.2021.03.07
   Xue B, 2016, FOOD FUNCT, V7, P1501, DOI 10.1039/c5fo01438g
   Yun SI, 2009, J APPL MICROBIOL, V107, P1681, DOI 10.1111/j.1365-2672.2009.04350.x
   [张伟 Zhang Wei], 2015, [中国药学杂志, Chinese Pharmaceutical Journal], V50, P1743
NR 78
TC 1
Z9 1
U1 3
U2 3
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1664-302X
J9 FRONT MICROBIOL
JI Front. Microbiol.
PD NOV 30
PY 2022
VL 13
AR 900021
DI 10.3389/fmicb.2022.900021
PG 14
WC Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology
GA 6Y2KH
UT WOS:000896928500001
PM 36532503
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Maniar, K
   Moideen, A
   Mittal, A
   Patil, A
   Chakrabarti, A
   Banerjee, D
AF Maniar, Kunal
   Moideen, Amal
   Mittal, Ankur
   Patil, Amol
   Chakrabarti, Amitava
   Banerjee, Dibyajyoti
TI A story of metformin-butyrate synergism to control various pathological
   conditions as a consequence of gut microbiome modification: Genesis of a
   wonder drug?
SO PHARMACOLOGICAL RESEARCH
LA English
DT Review
DE Metformin; Insulin; Diabetes mellitus; Antibiotics; NAFLD
ID POLYCYSTIC-OVARY-SYNDROME; ACTIVATED PROTEIN-KINASE; CHAIN FATTY-ACIDS;
   IMPAIRED GLUCOSE-TOLERANCE; TYPE-2 DIABETES-MELLITUS; GLUCAGON-LIKE
   PEPTIDE-1; INHIBITS HEPATIC GLUCONEOGENESIS; HISTONE DEACETYLASE
   INHIBITORS; CARDIOVASCULAR RISK-FACTORS; SERUM HOMOCYSTEINE LEVELS
AB The most widely prescribed oral anti-diabetic agent today in the world today is a member of the biguanide class of drugs called metformin. Apart from its use in diabetes, it is currently being investigated for its potential use in many diseases such as cancer, cardiovascular diseases, Alzheimer's disease, obesity, comorbidities of diabetes such as retinopathy, nephropathy to name a few. Numerous in-vitro and in-vivo studies as well as clinical trials have been and are being conducted with a vast amount of literature being published every day. Numerous mechanisms for this drug have been proposed, but they have been unable to explain all the actions observed clinically. It is of interest that insulin has a stimulatory effect on cellular growth. Metformin sensitizes the insulin action but believed to be beneficial in cancer. Like-wise metformin is shown to have beneficial effects in opposite sets of pathological scenario looking from insulin sensitization point of view. This requires a comprehensive review of the disease conditions which are claimed to be affected by metformin therapy. Such a comprehensive review is presently lacking. In this review, we begin by examining the history of metformin before it became the most popular anti diabetic medication today followed by a review of its relevant molecular mechanisms and important clinical trials in all areas where metformin has been studied and investigated till today. We also review novel mechanistic insight in metformin action in relation to microbiome and elaborate implications of such aspect in various disease states. Finally, we highlight the quandaries and suggest potential solutions which will help the researchers and physicians to channel their research and put this drug to better use. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Maniar, Kunal; Moideen, Amal; Patil, Amol; Chakrabarti, Amitava] Post Grad Inst Med Educ & Res, Dept Pharmacol, Chandigarh, India.
   [Mittal, Ankur; Banerjee, Dibyajyoti] Post Grad Inst Med Educ & Res, Dept Expt Med & Biotechnol, Res Block B,Sect 12, Chandigarh, India.
C3 Post Graduate Institute of Medical Education & Research (PGIMER),
   Chandigarh; Post Graduate Institute of Medical Education & Research
   (PGIMER), Chandigarh
RP Banerjee, D (通讯作者)，Post Grad Inst Med Educ & Res, Dept Expt Med & Biotechnol, Res Block B,Sect 12, Chandigarh, India.
EM dibyajyoti5200@yahoo.co.in
CR Adam AMA, 2015, SPECTROCHIM ACTA A, V149, P323, DOI 10.1016/j.saa.2015.04.115
   Adeyemo MA, 2015, DIABETES OBES METAB, V17, P363, DOI 10.1111/dom.12426
   Al Khalifah RA, 2015, SYST REV-LONDON, V4, DOI 10.1186/s13643-015-0105-4
   Allard JS, 2016, BEHAV BRAIN RES, V301, P1, DOI 10.1016/j.bbr.2015.12.012
   Alvaro A, 2008, IUBMB LIFE, V60, P757, DOI 10.1002/iub.110
   Anabtawi A, 2016, ENDOCR PRACT, V22, P999, DOI 10.4158/EP151145.RA
   ANDERSON JW, 1984, P SOC EXP BIOL MED, V177, P372
   Anedda A, 2008, J ENDOCRINOL, V199, P33, DOI 10.1677/JOE-08-0278
   [Anonymous], 2000, Diabetes Care, V23, P1619
   Apridonidze T, 2005, J CLIN ENDOCR METAB, V90, P1929, DOI 10.1210/jc.2004-1045
   Aroda VR, 2016, J CLIN ENDOCR METAB, V101, P1754, DOI 10.1210/jc.2015-3754
   Athukorala C, 2010, BMC PREGNANCY CHILDB, V10, DOI 10.1186/1471-2393-10-56
   Avenell A, 2004, HEALTH TECHNOL ASSES, V8, P1
   Bahari-Javan S, 2014, FRONT NEUROSCI-SWITZ, V8, DOI 10.3389/fnins.2014.00160
   Bailey C, 2004, PRACT DIAB INT, V21, P115, DOI [DOI 10.1002/PDI.606, 10.1002/pdi.606]
   Bailey CJ, 2008, DIABETOLOGIA, V51, P1552, DOI 10.1007/s00125-008-1053-5
   Bailey CJ, 1996, NEW ENGL J MED, V334, P574, DOI 10.1056/NEJM199602293340906
   Banerjee D, 2014, MED HYPOTHESES, V83, P88, DOI 10.1016/j.mehy.2014.04.002
   Banerjee D, 2011, ADV CLIN CHEM, V53, P139, DOI 10.1016/S0065-2423(11)53006-9
   Banks WA, 2012, PHARMACOL THERAPEUT, V136, P82, DOI 10.1016/j.pharmthera.2012.07.006
   Baur JA, 2014, CELL METAB, V20, P197, DOI 10.1016/j.cmet.2014.07.013
   Beauvieux Marie-Christine, 2008, BMC Physiology, V8, P19, DOI 10.1186/1472-6793-8-19
   Beauvieux MC, 2001, J NUTR, V131, P1986, DOI 10.1093/jn/131.7.1986
   BERCHTOLD P, 1971, SCAND J GASTROENTERO, V6, P751, DOI 10.3109/00365527109179948
   Bergmark BA, 2017, CIRCULATION, V136
   Berstein LM, 2012, AGING-US, V4, P320, DOI 10.18632/aging.100455
   Bertoldo MJ, 2014, ANN TRANSL MED, V2, DOI 10.3978/j.issn.2305-5839.2014.06.04
   Blouin JM, 2011, INT J CANCER, V128, P2591, DOI 10.1002/ijc.25599
   Bolen S, 2007, ANN INTERN MED, V147, P386, DOI 10.7326/0003-4819-147-6-200709180-00178
   Boursi B, 2015, EUR J ENDOCRINOL, V172, P639, DOI 10.1530/EJE-14-1163
   Boussageon R, 2012, PLOS MED, V9, DOI 10.1371/journal.pmed.1001204
   Brandao FAS, 2015, VIRULENCE, V6, P630, DOI 10.1080/21505594.2015.1038014
   Brim H, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0020216
   Bulterijs S, 2011, REJUV RES, V14, P469, DOI 10.1089/rej.2011.1153
   Burton Jeffrey H, 2015, J Diabetes Sci Technol, V9, P808, DOI 10.1177/1932296815577425
   Buse JB, 2016, DIABETES CARE, V39, P198, DOI 10.2337/dc15-0488
   Butzow TL, 2000, J CLIN ENDOCR METAB, V85, P3271, DOI 10.1210/jc.85.9.3271
   Cabezas MC, 2012, J NUTR METAB, V2012, DOI 10.1155/2012/394623
   Cabreiro F, 2013, CELL, V153, P228, DOI 10.1016/j.cell.2013.02.035
   Calvert JW, 2008, DIABETES, V57, P696, DOI 10.2337/db07-1098
   CAMPBELL IW, 1995, DIABETES METAB REV, V11, pS57, DOI 10.1002/dmr.5610110509
   Canani RB, 2011, WORLD J GASTROENTERO, V17, P1519, DOI [10.3748/wjg.v17.i12. 1519, 10.3748/wjg.v17.i12.1519]
   Carlsen SM, 1997, SCAND J CLIN LAB INV, V57, P521, DOI 10.3109/00365519709084603
   CARPENTIER JL, 1976, DIABETES METAB, V2, P187
   Carro E, 2004, EUR J PHARMACOL, V490, P127, DOI 10.1016/j.ejphar.2004.02.050
   Catteau-Jonard S, 2013, FRONT HORM RES, V40, P22, DOI 10.1159/000341679
   Cazzaniga M, 2013, BRIT J CANCER, V109, P2792, DOI 10.1038/bjc.2013.657
   Chae YK, 2016, ONCOTARGET, V7, P40767, DOI 10.18632/oncotarget.8194
   Chakraborty S., 2016, INT J DRUG DEV RES, V8, P35
   Chang CH, 2015, J CLIN ENDOCR METAB, V100, P1121, DOI 10.1210/jc.2014-2443
   Chang CH, 2009, NEUROSCI LETT, V467, P147, DOI 10.1016/j.neulet.2009.10.026
   Chapman LE, 2016, DIABETES METAB, V42, P316, DOI 10.1016/j.diabet.2016.03.008
   Charles MA, 2000, DIABETES-METAB RES, V16, P2, DOI 10.1002/(SICI)1520-7560(200001/02)16:1<2::AID-DMRR75>3.0.CO;2-G
   Chau-Van C, 2007, ENDOCRINOLOGY, V148, P507, DOI 10.1210/en.2006-1237
   Chen F, 2016, NEUROPHARMACOLOGY, V101, P123, DOI 10.1016/j.neuropharm.2015.07.023
   Chen YM, 2009, P NATL ACAD SCI USA, V106, P3907, DOI 10.1073/pnas.0807991106
   Chlebowski RT, 2012, J CLIN ONCOL, V30, P2844, DOI 10.1200/JCO.2011.39.7505
   Cifarelli V, 2015, DIABETES, V64, P1632, DOI 10.2337/db14-1132
   Col NF, 2012, BREAST CANCER RES TR, V135, P639, DOI 10.1007/s10549-012-2170-x
   Comalada M, 2006, J CANCER RES CLIN, V132, P487, DOI 10.1007/s00432-006-0092-x
   Correll CU, 2013, AM J PSYCHIAT, V170, P947, DOI 10.1176/appi.ajp.2013.13060771
   Cosma M, 2008, J CLIN ENDOCR METAB, V93, P1135, DOI 10.1210/jc.2007-2429
   Costello M, 2007, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD005552.pub2
   Costello MF, 2003, FERTIL STERIL, V79, P1, DOI 10.1016/S0015-0282(02)04554-5
   Costello MF, 2007, HUM REPROD, V22, P1200, DOI 10.1093/humrep/dem005
   Crane JMG, 2013, J OBSTET GYNAECOL CA, V35, P606, DOI 10.1016/S1701-2163(15)30879-3
   Crunkhorn S, 2011, NAT REV DRUG DISCOV, V10, P493, DOI 10.1038/nrd3483
   Cubeddu LX, 2000, N-S ARCH PHARMACOL, V361, P85, DOI 10.1007/s002109900152
   CUMMINGS JH, 1987, GUT, V28, P1221, DOI 10.1136/gut.28.10.1221
   Dallaglio K, 2014, CARCINOGENESIS, V35, P1055, DOI 10.1093/carcin/bgu001
   Dash A., 2011, CHRON YOUNG SCI, V2, P219, DOI DOI 10.4103/2229-5186.93029
   Day CP, 1998, GASTROENTEROLOGY, V114, P842, DOI 10.1016/S0016-5085(98)70599-2
   de Jager J, 2014, J INTERN MED, V275, P59, DOI 10.1111/joim.12128
   de Jager J, 2010, BMJ-BRIT MED J, V340, DOI 10.1136/bmj.c2181
   de Kreutzenberg SV, 2015, NUTR METAB CARDIOVAS, V25, P686, DOI 10.1016/j.numecd.2015.03.007
   De Lusong M.A., 2006, PHIL J GASTROENTEROL, V2, P53
   de Mola JRL, 2009, OBSTET GYN CLIN N AM, V36, P333, DOI 10.1016/j.ogc.2009.03.002
   De Silva A, 2012, GUT LIVER, V6, P10, DOI 10.5009/gnl.2012.6.1.10
   DeCensi A, 2015, CANCER PREV RES, V8, P888, DOI 10.1158/1940-6207.CAPR-15-0048
   DeFronzo RA, 2009, DIABETES CARE, V32, pS157, DOI 10.2337/dc09-S302
   den Besten G, 2015, DIABETES, V64, P2398, DOI 10.2337/db14-1213
   den Hertog HM, 2015, INT J STROKE, V10, P105, DOI 10.1111/ijs.12023
   Deng XS, 2012, CELL CYCLE, V11, P367, DOI 10.4161/cc.11.2.18813
   Dentin R, 2008, SCIENCE, V319, P1402, DOI 10.1126/science.1151363
   Deroanne CF, 2002, ONCOGENE, V21, P427, DOI 10.1038/sj.onc.1205108
   DeUgarte CM, 2005, FERTIL STERIL, V83, P1454, DOI 10.1016/j.fertnstert.2004.11.070
   Diabet Prevention Program Res Grp, 2005, DIABETES, V54, P1566
   Dilokthornsakul P, 2013, INT J GYNECOL CANCER, V23, P1544, DOI 10.1097/IGC.0b013e3182a80a21
   Dineley KT, 2014, NEUROBIOL DIS, V72, P92, DOI 10.1016/j.nbd.2014.09.001
   Pham DD, 2015, INT J PHARMACEUT, V478, P517, DOI 10.1016/j.ijpharm.2014.12.009
   Donohoe DR, 2012, MOL CELL, V48, P612, DOI 10.1016/j.molcel.2012.08.033
   Du Q, 2012, CURR MED RES OPIN, V28, P723, DOI 10.1185/03007995.2012.681636
   Duca FA, 2015, NAT MED, V21, P506, DOI 10.1038/nm.3787
   Dujic T, 2015, DIABETES, V64, P1786, DOI 10.2337/db14-1388
   Duncan SH, 2013, MATURITAS, V75, P44, DOI 10.1016/j.maturitas.2013.02.004
   Ehrmann DA, 2005, NEW ENGL J MED, V352, P1223, DOI 10.1056/NEJMra041536
   El Messaoudi S, 2015, LANCET DIABETES ENDO, V3, P615, DOI 10.1016/S2213-8587(15)00121-7
   Elkhal CK, 2015, FEBS J, V282, P3030, DOI 10.1111/febs.13233
   Eppinga RN, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0145719
   Ersoy C, 2008, DIABETES RES CLIN PR, V81, P56, DOI 10.1016/j.diabres.2008.02.006
   Eurich DT, 2013, CIRC-HEART FAIL, V6, P395, DOI 10.1161/CIRCHEARTFAILURE.112.000162
   Evans JMM, 2005, BMJ-BRIT MED J, V330, P1304, DOI 10.1136/bmj.38415.708634.F7
   Fadel JR, 2016, CURR OPIN BEHAV SCI, V9, P47, DOI 10.1016/j.cobeha.2015.12.004
   Faure P, 1999, DIABETES, V48, P353, DOI 10.2337/diabetes.48.2.353
   FDA, 2016, FDA DRUG SAF COMM FD
   Fernandez AM, 2012, NAT REV NEUROSCI, V13, P225, DOI 10.1038/nrn3209
   Fernandez-Garcia JC, 2014, CLIN ENDOCRINOL, V80, P671, DOI 10.1111/cen.12221
   Ferrari G, 1999, CELL, V97, P435, DOI 10.1016/S0092-8674(00)80754-0
   Filion KB, 2009, PHARMACOEPIDEM DR S, V18, P973, DOI 10.1002/pds.1802
   Fischer J., 2010, ANALOGUE BASED DRUG, V2, P47
   Fischer M, 2010, DIABETES OBES METAB, V12, P356, DOI 10.1111/j.1463-1326.2009.01169.x
   Fisher FM, 2011, ENDOCRINOLOGY, V152, P2996, DOI 10.1210/en.2011-0281
   Flannagan Ronald S, 2009, Nat Rev Microbiol, V7, P355, DOI 10.1038/nrmicro2128
   Fontbonne A, 1996, DIABETES CARE, V19, P920, DOI 10.2337/diacare.19.9.920
   Foretz M, 2010, J CLIN INVEST, V120, P2355, DOI 10.1172/JCI40671
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   FRAYN KN, 1973, CLIN SCI, V44, P55, DOI 10.1042/cs0440055
   Freemark M, 2001, PEDIATRICS, V107, DOI 10.1542/peds.107.4.e55
   Fulgencio JP, 2001, BIOCHEM PHARMACOL, V62, P439, DOI 10.1016/S0006-2952(01)00679-7
   Fullerton MD, 2013, NAT MED, V19, P1649, DOI 10.1038/nm.3372
   Gagnon J, 2013, DIABETES OBES METAB, V15, P276, DOI 10.1111/dom.12021
   Gallo A, 2005, DIABETES, V54, P1123, DOI 10.2337/diabetes.54.4.1123
   Galmozzi A, 2013, DIABETES, V62, P732, DOI 10.2337/db12-0548
   Gao ZG, 2009, DIABETES, V58, P1509, DOI 10.2337/db08-1637
   Garber AJ, 1997, AM J MED, V103, P491, DOI 10.1016/S0002-9343(97)00254-4
   Garinis GA, 2010, INT J OBESITY, V34, P1255, DOI 10.1038/ijo.2010.40
   Garinis G.A., 2010, INT J OBESITY, V34, P1255
   Gaur RV, 2015, INT J CONT MED, V3, P17, DOI DOI 10.5958/2321-1032.2015.00037.6
   Gentile CL, 2008, J NUTR BIOCHEM, V19, P567, DOI 10.1016/j.jnutbio.2007.10.001
   Giovannucci E, 2010, DIABETES CARE, V33, P1674, DOI 10.2337/dc10-0666
   Glister C, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0049553
   Glueck CJ, 2001, METABOLISM, V50, P856, DOI 10.1053/meta.2001.24192
   Godsland IF, 2010, CLIN SCI, V118, P315, DOI 10.1042/CS20090399
   Gokcel A, 2002, DIABETES OBES METAB, V4, P49, DOI 10.1046/j.1463-1326.2002.00181.x
   Golay A, 2008, INT J OBESITY, V32, P61, DOI 10.1038/sj.ijo.0803695
   Goldberg RB, 2009, DIABETES CARE, V32, P726, DOI 10.2337/dc08-0494
   Gottschalk M, 2007, DIABETES CARE, V30, P790, DOI 10.2337/dc06-1554
   Govindarajan N, 2011, J ALZHEIMERS DIS, V26, P187, DOI 10.3233/JAD-2011-110080
   Grant PJ, 1996, DIABETES CARE, V19, P64, DOI 10.2337/diacare.19.1.64
   Grisouard Jean, 2011, Archives of Physiology and Biochemistry, V117, P209, DOI 10.3109/13813455.2010.550925
   Grisouard J, 2010, BIOCHEM PHARMACOL, V80, P1736, DOI 10.1016/j.bcp.2010.08.021
   Gunton JE, 2003, J CLIN ENDOCR METAB, V88, P1323, DOI 10.1210/jc.2002-021394
   Gupta A, 2011, NEUROPHARMACOLOGY, V60, P910, DOI 10.1016/j.neuropharm.2011.01.033
   Haberland M, 2010, J BIOL CHEM, V285, P14663, DOI 10.1074/jbc.M109.081679
   Harborne L, 2003, J CLIN ENDOCR METAB, V88, P4116, DOI 10.1210/jc.2003-030424
   Hardie DG, 2013, CANCER CELL, V23, P131, DOI 10.1016/j.ccr.2013.01.009
   Hattori Y, 2015, DIABETES, V64, P1907, DOI 10.2337/db15-0090
   He G, 2003, HORM METAB RES, V35, P18, DOI 10.1055/s-2003-38386
   He L, 2009, CELL, V137, P635, DOI 10.1016/j.cell.2009.03.016
   Heimann E, 2015, ADIPOCYTE, V4, P81, DOI 10.4161/21623945.2014.960694
   Herman WH, 2012, DIABETES CARE, V35, P723, DOI 10.2337/dc11-1468
   Higurashi T, 2016, LANCET ONCOL, V17, P475, DOI 10.1016/S1470-2045(15)00565-3
   Hille A, 2008, STRAHLENTHER ONKOL, V184, P686, DOI 10.1007/s00066-008-1896-1
   Hirsch HA, 2013, P NATL ACAD SCI USA, V110, P972, DOI 10.1073/pnas.1221055110
   Hoeger K, 2001, OBSTET GYN CLIN N AM, V28, P85, DOI 10.1016/S0889-8545(05)70187-X
   Hofman A, 1997, LANCET, V349, P151, DOI 10.1016/S0140-6736(96)09328-2
   Hong J, 2013, DIABETES CARE, V36, P1304, DOI 10.2337/dc12-0719
   HOTAMISLIGIL GS, 1995, J CLIN INVEST, V95, P2409, DOI 10.1172/JCI117936
   Hsu CC, 2011, J ALZHEIMERS DIS, V24, P485, DOI 10.3233/JAD-2011-101524
   Huang NL, 2009, INT J CARDIOL, V134, P169, DOI 10.1016/j.ijcard.2008.04.010
   Huang Yao, 2011, Zhonghua Er Ke Za Zhi, V49, P139
   Huypens P, 2005, EUR J PHARMACOL, V518, P90, DOI 10.1016/j.ejphar.2005.06.016
   Hyun Bobae, 2013, Immune Netw, V13, P123, DOI 10.4110/in.2013.13.4.123
   Iannello S, 2004, DIABETES OBES METAB, V6, P8, DOI 10.1111/j.1463-1326.2004.00306.x
   Ibanez L, 2006, J CLIN ENDOCR METAB, V91, P2888, DOI 10.1210/jc.2006-0336
   Ibanez L, 2006, J CLIN ENDOCR METAB, V91, P2068, DOI 10.1210/jc.2005-2329
   Ibanez L, 2011, J CLIN ENDOCR METAB, V96, pE1262, DOI 10.1210/jc.2011-0555
   Imfeld P, 2012, J AM GERIATR SOC, V60, P916, DOI 10.1111/j.1532-5415.2012.03916.x
   Inzucchi SE, 2012, DIABETES CARE, V35, P1364, DOI 10.2337/dc12-0413
   Ishibashi Y, 2012, HORM METAB RES, V44, P891, DOI 10.1055/s-0032-1321878
   Joe SG, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0119708
   Johnson N, 2011, AUST NZ J OBSTET GYN, V51, P125, DOI 10.1111/j.1479-828X.2010.01274.x
   Jornayvaz FR, 2012, CELL METAB, V15, P574, DOI 10.1016/j.cmet.2012.03.005
   Kajbaf F, 2013, DIABETIC MED, V30, P345, DOI 10.1111/dme.12017
   Kalinsky K, 2014, CANCER INVEST, V32, P150, DOI 10.3109/07357907.2014.889706
   Kalogeris T, 2014, REDOX BIOL, V2, P702, DOI 10.1016/j.redox.2014.05.006
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kendall D, 2013, J CLIN ENDOCR METAB, V98, P322, DOI 10.1210/jc.2012-2710
   Khan S, 2016, CHEM-BIOL INTERACT, V254, P124, DOI 10.1016/j.cbi.2016.06.007
   Kickstein E, 2010, P NATL ACAD SCI USA, V107, P21830, DOI 10.1073/pnas.0912793107
   Kilgore M, 2010, NEUROPSYCHOPHARMACOL, V35, P870, DOI 10.1038/npp.2009.197
   Kim J, 2014, J BIOL CHEM, V289, P23246, DOI 10.1074/jbc.M114.577908
   Kim S.W., 2012, Patent No. [US 20120135952 Al, 20120135952]
   Kim YD, 2008, DIABETES, V57, P306, DOI 10.2337/db07-0381
   Kim YW, 2006, DIABETES, V55, P716, DOI 10.2337/diabetes.55.03.06.db05-0917
   Kimura I, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms2852
   Klein J, 2004, J ENDOCRINOL, V183, P299, DOI 10.1677/joe.1.05646
   Kloppenborg RP, 2008, EUR J PHARMACOL, V585, P97, DOI 10.1016/j.ejphar.2008.02.049
   Kmetzsch L, 2015, VIRULENCE, V6, P562, DOI 10.1080/21505594.2015.1049807
   Knowler WC, 2009, LANCET, V374, P1677, DOI [10.1016/S0140-6736(09)61457-4, DOI 10.1016/S0140-6736(09)61457-4]
   Kohjima M, 2008, INT J MOL MED, V21, P507
   Kordes S, 2015, LANCET ONCOL, V16, P839, DOI 10.1016/S1470-2045(15)00027-3
   Koren-Gluzer M, 2013, BIOCHEM BIOPH RES CO, V439, P396, DOI 10.1016/j.bbrc.2013.08.062
   Koritzinsky M, 2015, INT J RADIAT ONCOL, V93, P454, DOI 10.1016/j.ijrobp.2015.06.003
   Kou CZ, 2011, MOL CELL BIOCHEM, V348, P149, DOI 10.1007/s11010-010-0649-5
   Krautler B, 2005, BIOCHEM SOC T, V33, P806
   Kritharis A., J CLIN ONCOL
   Kroner Z, 2009, ALTERN MED REV, V14, P373
   Krupitza G, 1996, BRIT J CANCER, V73, P433, DOI 10.1038/bjc.1996.78
   Lai SW, 2012, AM J GASTROENTEROL, V107, P46, DOI 10.1038/ajg.2011.384
   Lamanna C, 2011, DIABETES OBES METAB, V13, P221, DOI 10.1111/j.1463-1326.2010.01349.x
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Lee A, 1998, OBES RES, V6, P47, DOI 10.1002/j.1550-8528.1998.tb00314.x
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Lee H, 2016, NAT NANOTECHNOL, V11, P566, DOI [10.1038/nnano.2016.38, 10.1038/NNANO.2016.38]
   Lee KM, 2016, ONCOTARGET, V7, P38500, DOI 10.18632/oncotarget.9522
   Leone A, 2014, CANCER TREAT RES, V159, P355, DOI 10.1007/978-3-642-38007-5_21
   Levri KM, 2005, ANN FAM MED, V3, P457, DOI 10.1370/afm.343
   Lexis CPH, 2015, BMJ OPEN DIAB RES CA, V3, DOI [10.1136/bmjdrc-2015000090, 10.1136/bmjdrc-2015-000090]
   Lexis CPH, 2014, JAMA-J AM MED ASSOC, V311, P1526, DOI 10.1001/jama.2014.3315
   Li HP, 2013, INT J CLIN EXP PATHO, V6, P1574
   Li HT, 2012, DIABETES, V61, P797, DOI 10.2337/db11-0846
   Li L, 2014, CLIN CANCER RES, V20, P2714, DOI 10.1158/1078-0432.CCR-13-2613
   Li R, 2010, DIABETES CARE, V33, P1872, DOI 10.2337/dc10-0843
   Li XJ, 2011, CLIN ENDOCRINOL, V74, P332, DOI 10.1111/j.1365-2265.2010.03917.x
   Li Y, 2013, BIOMED REP, V1, P57, DOI 10.3892/br.2012.18
   Liang DM, 2006, CELL CYCLE, V5, P2430, DOI 10.4161/cc.5.21.3409
   Liao L, 2011, CHINESE MED J-PEKING, V124, P714, DOI 10.3760/cma.j.issn.0366-6999.2011.05.015
   Libby G, 2009, DIABETES CARE, V32, P1620, DOI 10.2337/dc08-2175
   Lilly M, 2009, CAN FAM PHYSICIAN, V55, P363
   LIN ECC, 1976, ANNU REV MICROBIOL, V30, P535, DOI 10.1146/annurev.mi.30.100176.002535
   Lin HP, 2012, PLOS ONE, V7, DOI [10.1371/journal.pone.0031286, 10.1371/journal.pone.0035240]
   Lin HZ, 2000, NAT MED, V6, P998, DOI 10.1038/79697
   Lin JJ, 2015, AM J RESP CRIT CARE, V191, P448, DOI 10.1164/rccm.201407-1395OC
   Liu F, 2014, INT J MOL MED, V33, P51, DOI 10.3892/ijmm.2013.1560
   Liu J, 2015, DIABETES-METAB RES, V31, P329, DOI 10.1002/dmrr.2580
   Nguyen LN, 2011, J ANTIMICROB CHEMOTH, V66, P2573, DOI 10.1093/jac/dkr358
   Lord J.M., 2003, COCHRANE DB SYST REV, DOI DOI 10.1002/14651858.CD003053
   Louro TM, 2011, EUR J PHARMACOL, V653, P89, DOI 10.1016/j.ejphar.2010.11.029
   Luchsinger JA, 2007, ARCH NEUROL-CHICAGO, V64, P570, DOI 10.1001/archneur.64.4.570
   Luchsinger JA, 2016, J ALZHEIMERS DIS, V51, P501, DOI 10.3233/JAD-150493
   Luo F, 2016, LIPIDS HEALTH DIS, V15, DOI 10.1186/s12944-016-0281-9
   Macia L, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms7734
   Madiraju AK, 2014, NATURE, V510, P542, DOI 10.1038/nature13270
   Maggio A, 2014, INT J RADIAT ONCOL, V89, P518, DOI 10.1016/j.ijrobp.2014.03.018
   Mannucci E, 2004, DIABETES NUTR METAB, V17, P336
   Mannucci E, 2001, DIABETES CARE, V24, P489, DOI 10.2337/diacare.24.3.489
   Mao XM, 2006, NAT CELL BIOL, V8, P516, DOI 10.1038/ncb1404
   Marchesini G, 2016, HEPATOLOGY, V63, P2032, DOI 10.1002/hep.28392
   Marcil V, 2003, J NUTR, V133, P2180, DOI 10.1093/jn/133.7.2180
   Mardinoglu A, 2016, CELL METAB, V23, P10, DOI 10.1016/j.cmet.2015.12.012
   Matsumoto N, 2006, KIDNEY INT, V69, P257, DOI 10.1038/sj.ki.5000028
   Mattos KA, 2014, CELL MICROBIOL, V16, P797, DOI 10.1111/cmi.12279
   Mauras N, 2012, J PEDIATR ENDOCR MET, V25, P33, DOI 10.1515/jpem-2011-0450
   Mazza A, 2012, EXP DIABETES RES, DOI 10.1155/2012/716404
   Mc Menamin UC, 2016, INT J CANCER, V138, P369, DOI 10.1002/ijc.29720
   McCreight LJ, 2016, DIABETOLOGIA, V59, P426, DOI 10.1007/s00125-015-3844-9
   Meijer K, 2010, CURR OPIN CLIN NUTR, V13, P715, DOI 10.1097/MCO.0b013e32833eebe5
   Mells JE, 2013, SEMIN LIVER DIS, V33, P343, DOI 10.1055/s-0033-1358527
   Mikkelsen KH, 2015, J CLIN ENDOCR METAB, V100, P3633, DOI 10.1210/jc.2015-2696
   Miller JL, 2010, PLOS PATHOG, V6, DOI 10.1371/journal.ppat.1000864
   Miller RA, 2013, NATURE, V494, P256, DOI 10.1038/nature11808
   Miller RA, 2010, J CLIN INVEST, V120, P2267, DOI 10.1172/JCI43661
   Mohammadi M., 2009, INT J MED MED SCI, V1, P88
   Mojtahedzadeh M, 2008, ARCH MED SCI, V4, P174
   Moore EM, 2013, DIABETES CARE, V36, P2981, DOI 10.2337/dc13-0229
   Morales DR, 2015, ANNU REV MED, V66, P17, DOI 10.1146/annurev-med-062613-093128
   Mourao CA, 2006, BRAZ J MED BIOL RES, V39, P489, DOI 10.1590/S0100-879X2006000400009
   Mracek T, 2013, BBA-BIOENERGETICS, V1827, P401, DOI 10.1016/j.bbabio.2012.11.014
   Mulherin AJ, 2011, ENDOCRINOLOGY, V152, P4610, DOI 10.1210/en.2011-1485
   Musi N, 2002, DIABETES, V51, P2074, DOI 10.2337/diabetes.51.7.2074
   Naderpoor N, 2015, HUM REPROD UPDATE, V21, P560, DOI 10.1093/humupd/dmv025
   Napolitano A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100778
   Nathan DM, 2015, LANCET DIABETES ENDO, V3, P866, DOI 10.1016/S2213-8587(15)00291-0
   NATTRASS M, 1978, DIABETOLOGIA, V14, P71, DOI 10.1007/BF01263443
   Nedjadi T, 2014, EXP PHYSIOL, V99, P1335, DOI 10.1113/expphysiol.2014.077982
   Ng Marie, 2014, Lancet, V384, P766, DOI 10.1016/S0140-6736(14)60460-8
   Niafar M, 2015, INTERN EMERG MED, V10, P93, DOI 10.1007/s11739-014-1157-5
   Niazi AK, 2012, J DIABETES METAB DIS, V11, DOI 10.1186/2251-6581-11-28
   Nilsson AC, 2010, J NUTR, V140, P1932, DOI 10.3945/jn.110.123604
   NOBELS F, 1992, FERTIL STERIL, V58, P655
   Novelle MG, 2016, CSH PERSPECT MED, V6, DOI 10.1101/cshperspect.a025932
   Obara A, 2015, BIOCHEM BIOPH RES CO, V460, P1047, DOI 10.1016/j.bbrc.2015.03.148
   Ohira H, 2013, J ATHEROSCLER THROMB, V20, P425, DOI 10.5551/jat.15065
   Oiso H, 2011, BIOCHEM BIOPH RES CO, V404, P166, DOI 10.1016/j.bbrc.2010.11.086
   OLEFSKY JM, 1977, DIABETES, V26, P680, DOI 10.2337/diab.26.7.680
   Owen MR, 2000, BIOCHEM J, V348, P607, DOI 10.1042/0264-6021:3480607
   Palomba S, 2014, REPROD BIOL ENDOCRIN, V12, DOI 10.1186/1477-7827-12-3
   Parihar SP, 2014, J INFECT DIS, V209, P754, DOI 10.1093/infdis/jit550
   Parihar SP, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0075490
   Park DW, 2013, MOL MED, V19, P387, DOI 10.2119/molmed.2013.00065
   Parlevliet ET, 2010, AM J PHYSIOL-ENDOC M, V299, pE318, DOI 10.1152/ajpendo.00191.2010
   PEDERSEN O, 1989, DIABETIC MED, V6, P249, DOI 10.1111/j.1464-5491.1989.tb01156.x
   Peng M, 2016, ONCOTARGET, V7, P9102, DOI 10.18632/oncotarget.6933
   Pieters J, 2001, MICROBES INFECT, V3, P249, DOI 10.1016/S1286-4579(01)01376-4
   Piwkowska A, 2013, ACTA BIOCHIM POL, V60, P607
   Plotkin BJ, 2000, CURR MICROBIOL, V41, P60, DOI 10.1007/s002840010092
   Potthoff MJ, 2009, P NATL ACAD SCI USA, V106, P10853, DOI 10.1073/pnas.0904187106
   Pradhan AD, 2009, JAMA-J AM MED ASSOC, V302, P1186, DOI 10.1001/jama.2009.1347
   Preiss D., 2016, DIABETES OBES METAB
   Preiss D, 2014, LANCET DIABETES ENDO, V2, P116, DOI 10.1016/S2213-8587(13)70152-9
   Proctor WR, 2008, DRUG METAB DISPOS, V36, P1650, DOI 10.1124/dmd.107.020180
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Qin ZY, 2014, EXP BIOL MED, V239, P1567, DOI 10.1177/1535370214537746
   Qiu AD, 2006, CELL, V127, P917, DOI 10.1016/j.cell.2006.09.041
   Qiu Chengxuan, 2009, Dialogues Clin Neurosci, V11, P111
   Quan C, 2008, EUR J GASTROEN HEPAT, V20, P888, DOI 10.1097/MEG.0b013e3282f5f734
   Ramachandran A, 2006, DIABETOLOGIA, V49, P289, DOI 10.1007/s00125-005-0097-z
   Reaven Gerald, 2005, Diab Vasc Dis Res, V2, P105, DOI 10.3132/dvdr.2005.017
   Rebello CJ, 2015, J DIABETES COMPLICAT, V29, P1272, DOI 10.1016/j.jdiacomp.2015.08.023
   Rego DF, 2015, ORAL ONCOL, V51, P416, DOI 10.1016/j.oraloncology.2015.01.007
   Ren TT, 2006, J MOL ENDOCRINOL, V37, P175, DOI 10.1677/jme.1.02061
   Rice S, 2013, J CLIN ENDOCR METAB, V98, pE1491, DOI 10.1210/jc.2013-1865
   Rizos CV, 2013, EUR J PHARMACOL, V705, P96, DOI 10.1016/j.ejphar.2013.02.038
   Rouabhia S, 2014, EXPERT REV GASTROENT, V8, P343, DOI 10.1586/17474124.2014.894880
   Roumie CL, 2012, ANN INTERN MED, V157, P601, DOI 10.7326/0003-4819-157-9-201211060-00003
   Rowan JA, 2011, DIABETES CARE, V34, P2279, DOI 10.2337/dc11-0660
   Rumberger JM, 2014, PEERJ, V2, DOI 10.7717/peerj.611
   Saenz A, 2005, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD002966.pub3
   Sahin M, 2007, J DIABETES COMPLICAT, V21, P118, DOI 10.1016/j.jdiacomp.2005.10.005
   Said HM, 1999, CURR OPIN GASTROEN, V15, P172, DOI 10.1097/00001574-199903000-00015
   Saisho Y, 2015, ENDOCR METAB IMMUNE, V15, P196, DOI 10.2174/1871530315666150316124019
   Sajan MP, 2010, AM J PHYSIOL-ENDOC M, V298, pE179, DOI 10.1152/ajpendo.00392.2009
   Sajan MP, 2013, DIABETOLOGIA, V56, P2507, DOI 10.1007/s00125-013-3010-1
   Salpeter SR, 2008, AM J MED, V121, P149, DOI 10.1016/j.amjmed.2007.09.016
   Sasaoka T, 2000, ENDOCR J, V47, P373, DOI 10.1507/endocrj.47.373
   Scale T, 2011, CLIN ENDOCRINOL, V74, P191, DOI 10.1111/j.1365-2265.2010.03891.x
   Scarpello JHB, 2003, DIABETES METAB, V29, pS36
   Scharlau D, 2009, MUTAT RES-REV MUTAT, V682, P39, DOI 10.1016/j.mrrev.2009.04.001
   Schroeder GN, 2008, CLIN MICROBIOL REV, V21, P134, DOI 10.1128/CMR.00032-07
   Schuler KM, 2015, CANCER MED-US, V4, P161, DOI 10.1002/cam4.353
   Schwartz S, 2006, DIABETES CARE, V29, P759, DOI 10.2337/diacare.29.04.06.dc05-1967
   Sena CM, 2011, BRIT J PHARMACOL, V163, P424, DOI 10.1111/j.1476-5381.2011.01230.x
   Sengupta S, 2006, J GASTROEN HEPATOL, V21, P209, DOI 10.1111/j.1440-1746.2006.04213.x
   Shackelford DB, 2013, CANCER CELL, V23, P143, DOI 10.1016/j.ccr.2012.12.008
   Shaw RJ, 2005, SCIENCE, V310, P1642, DOI 10.1126/science.1120781
   Sims-Robinson C, 2010, NAT REV NEUROL, V6, P551, DOI 10.1038/nrneurol.2010.130
   Singhal A, 2014, SCI TRANSL MED, V6, DOI 10.1126/scitranslmed.3009885
   Smiechowski BB, 2013, DIABETES CARE, V36, P124, DOI 10.2337/dc12-0740
   Smieszek A., 2015, J DIABETES RES, V9
   Soliman MM, 2011, J VET SCI, V12, P319, DOI 10.4142/jvs.2011.12.4.319
   Song CW, 2012, SCI REP-UK, V2, DOI 10.1038/srep00362
   Sozio MS, 2011, AM J PHYSIOL-GASTR L, V301, pG739, DOI [10.1152/ajpgi.00161.2011, 10.1152/ajpgi.00432.2010]
   Staehr P, 2003, DIABETES, V52, P260, DOI 10.2337/diabetes.52.2.260
   STANIER RY, 1962, ARCH MIKROBIOL, V42, P17, DOI 10.1007/BF00425185
   Sterne J., 1957, MAROC MED, V36, P1295
   Stevens RJ, 2012, DIABETOLOGIA, V55, P2593, DOI 10.1007/s00125-012-2653-7
   Stocker DJ, 2007, AM HEART J, V153, DOI 10.1016/j.ahj.2006.11.005
   Stopsack KH, 2016, CANCER CAUSE CONTROL, V27, P105, DOI 10.1007/s10552-015-0687-0
   Suissa S, 2012, DIABETES CARE, V35, P2665, DOI 10.2337/dc12-0788
   Sum C.F., DIABETES MED J BR DI, V9
   Sun JC, 2015, PLOS COMPUT BIOL, V11, DOI 10.1371/journal.pcbi.1004202
   Sun Z, 2012, NAT MED, V18, P934, DOI 10.1038/nm.2744
   Syngelaki A, 2016, NEW ENGL J MED, V374, P434, DOI 10.1056/NEJMoa1509819
   Takashima M, 2010, DIABETES, V59, P1608, DOI 10.2337/db09-1679
   Takiyama Y, 2011, DIABETES, V60, P981, DOI 10.2337/db10-0655
   Tang T, 2012, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD003053.pub5
   Tarlatzis BC, 2008, HUM REPROD, V23, P462, DOI 10.1093/humrep/dem426
   Tarr Joanna M, 2013, ISRN Ophthalmol, V2013, P343560, DOI 10.1155/2013/343560
   Tek C, 2014, EVID-BASED MENT HEAL, V17, P51, DOI 10.1136/eb-2014-101760
   TENG MH, 1976, P NATL ACAD SCI USA, V73, P3173, DOI 10.1073/pnas.73.9.3173
   Thackray G. Varykina, 2016, DIFFER PERSPECT COMM
   Tosca L, 2011, BIOL REPROD, V84, P351, DOI 10.1095/biolreprod.110.087023
   TOSCANI A, 1990, J BIOL CHEM, V265, P5722
   Trayhurn P, 2004, BRIT J NUTR, V92, P347, DOI 10.1079/BJN20041213
   Tseng CH, 2012, EUR J ENDOCRINOL, V167, P409, DOI 10.1530/EJE-12-0369
   Tsilchorozidou T, 2004, CLIN ENDOCRINOL, V60, P1, DOI 10.1046/j.1365-2265.2003.01842.x
   Tso LO, 2014, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD006105.pub3
   TUCKER GT, 1981, BRIT J CLIN PHARMACO, V12, P235
   Turban S, 2012, J BIOL CHEM, V287, P20088, DOI 10.1074/jbc.M111.330746
   Turner RC, 1998, LANCET, V352, P837, DOI 10.1016/s0140-6736(98)07019-6
   Upadhyay TR, 2016, J CLIN DIAGN RES, V10, pBC1, DOI 10.7860/JCDR/2016/17604.7518
   Vaiserman A. M., 2012, Frontiers in Genetics, V3, P224, DOI 10.3389/fgene.2012.00224
   Vaiserman A M, 2012, Adv Gerontol, V25, P126
   van Zuuren EJ, 2015, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD010334.pub2
   Vasamsetti SB, 2015, DIABETES, V64, P2028, DOI 10.2337/db14-1225
   Vashisht R, 2015, J TRANSL MED, V13, DOI 10.1186/s12967-015-0443-y
   Vazquez-Martin A, 2008, CELL PROLIFERAT, V41, P59, DOI 10.1111/j.1365-2184.2007.00498.x
   Vecchio S, 2014, CLIN TOXICOL, V52, P129, DOI 10.3109/15563650.2013.860985
   VELAZQUEZ EM, 1994, METABOLISM, V43, P647, DOI 10.1016/0026-0495(94)90209-7
   Vernia P, 2000, LANCET, V356, P1232, DOI 10.1016/S0140-6736(00)02787-2
   Ververis K, 2013, BIOL-TARGETS THER, V7, P47, DOI 10.2147/BTT.S29965
   Videla LA, 2012, PPAR RES, V2012, DOI 10.1155/2012/107434
   Wang C, 2014, CLIN LAB, V60, P887, DOI 10.7754/Clin.Lab.2013.130531
   Wang Chen-Pin, 2014, J Endocrinol Diabetes Obes, V2
   Wang J, 2012, CELL STEM CELL, V11, P23, DOI 10.1016/j.stem.2012.03.016
   Wang Wei, 2006, Beijing Da Xue Xue Bao Yi Xue Ban, V38, P170
   Wang XK, 2015, SCI REP-UK, V5, DOI 10.1038/srep12676
   WARBURG O, 1956, SCIENCE, V123, P309, DOI 10.1126/science.123.3191.309
   Willemsen RH, 2014, NAT REV ENDOCRINOL, V10, P352, DOI 10.1038/nrendo.2014.40
   Witters LA, 2001, J CLIN INVEST, V108, P1105, DOI 10.1172/JCI14178
   Woudenberg-Vrenken TE, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0071773
   Wu WJ, 2015, INT J MOL MED, V35, P1734, DOI 10.3892/ijmm.2015.2187
   Wulffele MG, 2003, J INTERN MED, V254, P455, DOI 10.1046/j.1365-2796.2003.01213.x
   Xu Jing, 2013, Zhong Nan Da Xue Xue Bao Yi Xue Ban, V38, P882, DOI 10.3969/j.issn.1672-7347.2013.09.003
   Xu W, 2015, TRANSL RES, V166, P451, DOI 10.1016/j.trsl.2015.06.002
   Yang ZG, 2015, AM J TRANSL RES, V7, P1850
   Yarchoan M, 2014, DIABETES, V63, P2253, DOI 10.2337/db14-0287
   Yatsunenko T, 2012, NATURE, V486, P222, DOI 10.1038/nature11053
   Yee SW, 2015, J PHARMACOKINET PHAR, V42, P463, DOI 10.1007/s10928-015-9436-y
   Yin M, 2013, ONCOLOGIST, V18, P1248, DOI 10.1634/theoncologist.2013-0111
   Zakikhani M, 2010, BREAST CANCER RES TR, V123, P271, DOI 10.1007/s10549-010-0763-9
   Zannella VE, 2013, CLIN CANCER RES, V19, P6741, DOI 10.1158/1078-0432.CCR-13-1787
   Zhai LM, 2015, J DIABETES RES, V2015, DOI 10.1155/2015/231825
   Zhao YM, 2005, J EXP BIOL, V208, P697, DOI 10.1242/jeb.01439
   Zhou GC, 2001, J CLIN INVEST, V108, P1167, DOI 10.1172/JCI200113505
   Zhuo ZH, 2014, J DIABETES RES, V2014, DOI 10.1155/2014/381231
   Zou T, 2011, INFECT IMMUN, V79, P1526, DOI 10.1128/IAI.01195-10
   Zulian A, 2011, OBESITY FACTS, V4, P27, DOI 10.1159/000324582
NR 399
TC 48
Z9 52
U1 0
U2 38
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-6618
EI 1096-1186
J9 PHARMACOL RES
JI Pharmacol. Res.
PD MAR
PY 2017
VL 117
BP 103
EP 128
DI 10.1016/j.phrs.2016.12.003
PG 26
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA EN2MQ
UT WOS:000395845000012
PM 27939359
DA 2023-06-08
ER

PT J
AU Ahmadi, S
   Razazan, A
   Nagpal, R
   Jain, S
   Wang, B
   Mishra, SP
   Wang, SH
   Justice, J
   Ding, JZ
   McClain, DA
   Kritchevsky, SB
   Kitzman, D
   Yadav, H
AF Ahmadi, Shokouh
   Razazan, Atefeh
   Nagpal, Ravinder
   Jain, Shalini
   Wang, Bo
   Mishra, Sidharth P.
   Wang, Shaohua
   Justice, Jamie
   Ding, Jingzhong
   McClain, Donald A.
   Kritchevsky, Stephen B.
   Kitzman, Dalane
   Yadav, Hariom
TI Metformin Reduces Aging-Related Leaky Gut and Improves Cognitive
   Function by Beneficially Modulating Gut Microbiome/Goblet Cell/Mucin
   Axis
SO JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL
   SCIENCES
LA English
DT Article
DE Gut permeability; Inflammation; Microbiota; Mucus; Wnt signaling
ID SYSTEMIC INFLAMMATION; BRAIN; AGE; MICROBIOTA; NEUROINFLAMMATION;
   GLUCOSE; PROTEIN; OBESITY; HEALTH
AB Aging-related illnesses are increasing and effective strategies to prevent and/or treat them are lacking. This is because of a poor understanding of therapeutic targets. Low-grade inflammation is often higher in older adults and remains a key risk factor of aging-related morbidities and mortalities. Emerging evidence indicates that abnormal (dysbiotic) gut microbiome and dysfunctional gut permeability (leaky gut) are linked with increased inflammation in older adults. However, currently available drugs do not treat aging-related microbiome dysbiosis and leaky gut, and little is known about the cellular and molecular processes that can be targeted to reduce leaky gut in older adults. Here, we demonstrated that metformin, a safe Food and Drug Administration-approved antidiabetic drug, decreased leaky gut and inflammation in high-fat diet-fed older obese mice, by beneficially modulating the gut microbiota. In addition, metformin increased goblet cell mass and mucin production in the obese older gut, thereby decreasing leaky gut and inflammation. Mechanistically, metformin increased the goblet cell differentiation markers by suppressing Wnt signaling. Our results suggest that metformin can be used as a regimen to prevent and treat aging-related leaky gut and inflammation, especially in obese individuals and people with western-style high-fat dietary lifestyle, by beneficially modulating gut microbiome/goblet cell/mucin biology.
C1 [Ahmadi, Shokouh; Razazan, Atefeh; Nagpal, Ravinder; Mishra, Sidharth P.; Wang, Shaohua; Yadav, Hariom] Wake Forest Sch Med, Dept Internal Med Mol Med, Biotech Pl,Suite 2E-034,575 Patterson Ave, Winston Salem, NC 27101 USA.
   [Jain, Shalini; McClain, Donald A.] Wake Forest Sch Med, Dept Endocrinol & Metab, Winston Salem, NC 27101 USA.
   [Jain, Shalini; McClain, Donald A.] Wake Forest Sch Med, Mouse Metab Phenotyping Core, Winston Salem, NC 27101 USA.
   [Wang, Bo] North Carolina A&T State Univ, Dept Chem, Greensboro, NC USA.
   [Justice, Jamie; Ding, Jingzhong; Kritchevsky, Stephen B.; Kitzman, Dalane] Wake Forest Sch Med, Dept Internal Med Gerontol & Geriatr Med, Winston Salem, NC 27101 USA.
   [Kitzman, Dalane] Wake Forest Sch Med, Dept Cardiol, Winston Salem, NC 27101 USA.
   [Yadav, Hariom] Wake Forest Sch Med, Dept Microbiol & Immunol, Winston Salem, NC 27101 USA.
C3 Wake Forest University; Wake Forest University; Wake Forest University;
   University of North Carolina; North Carolina A&T State University; Wake
   Forest University; Wake Forest University; Wake Forest University
RP Yadav, H (通讯作者)，Wake Forest Sch Med, Dept Internal Med Mol Med, Biotech Pl,Suite 2E-034,575 Patterson Ave, Winston Salem, NC 27101 USA.
EM hyadav@wakehealth.edu
RI Nagpal, Ravinder/H-5358-2019; Ahmadi, Shokouh/ABA-1007-2020; Justice,
   Jamie/AAW-9590-2021; Wang, Shaohua/G-8194-2018; Yadav,
   Hariom/I-2455-2018
OI Nagpal, Ravinder/0000-0002-4250-1749; Ahmadi,
   Shokouh/0000-0003-2766-1098; Justice, Jamie/0000-0003-2953-4404; Wang,
   Shaohua/0000-0002-8548-1602; Yadav, Hariom/0000-0003-4504-1597
FU National Institutes of Health [K01AG059837, RF1AG054474, U01AG060897,
   R01DK103531, R01DK081842, R01AG059416, U13AG040938, R01AG052419,
   U24AG058556, KL2TR001421, R01AG018915, R01AG045551, U24AG059624]; Pepper
   Older Americans for Independence Center [P30AG21332]; Department of
   Defense [W81XWH-18-1-0118, W81XWH-19-1-0236]; Center for Diabetes,
   Obesity and Metabolism; Wake Forest Baptist Medical Center; National
   Center for Advancing Translational Sciences (NCATS), the National
   Institutes of Health [UL1TR001420]
FX This study was supported by the National Institutes of
   Health-K01AG059837 (J.J.), RF1AG054474, U01AG060897, R01DK103531 (J.D.),
   R01DK081842 (D.A.M.), R01AG059416, U13AG040938, R01AG052419,
   U24AG058556, KL2TR001421 (S.B.K.), R01AG018915, R01AG045551, U24AG059624
   (D.W.K.) and the Pepper Older Americans for Independence Center
   (P30AG21332), and the Department of Defense-W81XWH-18-1-0118 and
   W81XWH-19-1-0236 (H.Y.), as well funds and services provided from the
   Center for Diabetes, Obesity and Metabolism, Wake Forest Baptist Medical
   Center, and the National Center for Advancing Translational Sciences
   (NCATS), the National Institutes of Health-funded Wake Forest Clinical,
   and Translational Science Institute (WF CTSI) through Grant Award Number
   UL1TR001420.
CR Algire C, 2012, CANCER PREV RES, V5, P536, DOI 10.1158/1940-6207.CAPR-11-0536
   Ames BN, 2018, P NATL ACAD SCI USA, V115, P10836, DOI 10.1073/pnas.1809045115
   Apovian CM, 2008, ARTERIOSCL THROM VAS, V28, P1654, DOI 10.1161/ATVBAHA.108.170316
   Arai H, 2018, CLIN GERIATR MED, V34, P667, DOI 10.1016/j.cger.2018.06.011
   Barzilai N, 2016, CELL METAB, V23, P1060, DOI 10.1016/j.cmet.2016.05.011
   Bektas A, 2018, EXP GERONTOL, V105, P10, DOI 10.1016/j.exger.2017.12.015
   Bertolotti M, 2014, WORLD J GASTROENTERO, V20, P14185, DOI 10.3748/wjg.v20.i39.14185
   Bischof GN, 2015, PSYCHOSOM MED, V77, P697, DOI 10.1097/PSY.0000000000000212
   Blazer DG, 2015, JAMA-J AM MED ASSOC, V313, P2121, DOI 10.1001/jama.2015.4380
   Buford TW, 2018, GEROSCIENCE, V40, P257, DOI 10.1007/s11357-018-0026-y
   Buford TW, 2017, MICROBIOME, V5, DOI 10.1186/s40168-017-0296-0
   Buse JB, 2016, DIABETES CARE, V39, P198, DOI 10.2337/dc15-0488
   Cabreiro F, 2013, CELL, V153, P228, DOI 10.1016/j.cell.2013.02.035
   Chen YX, 2019, ADV EXP MED BIOL, V1128, P103, DOI 10.1007/978-981-13-3540-2_6
   Cholerton Brenna, 2016, Diabetes Spectr, V29, P210
   Cornick S, 2015, TISSUE BARRIERS, V3, DOI 10.4161/21688370.2014.982426
   Dominguez LJ, 2016, CURR OPIN CLIN NUTR, V19, P5, DOI 10.1097/MCO.0000000000000243
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Garg G, 2017, REJUV RES, V20, P173, DOI 10.1089/rej.2016.1883
   Godbout JP, 2006, NEUROL CLIN, V24, P521, DOI 10.1016/j.ncl.2006.03.010
   Gratton J, 2016, ANAL CHEM, V88, P4661, DOI 10.1021/acs.analchem.5b04159
   Heuberger J, 2014, P NATL ACAD SCI USA, V111, P3472, DOI 10.1073/pnas.1309342111
   Kickstein E, 2010, P NATL ACAD SCI USA, V107, P21830, DOI 10.1073/pnas.0912793107
   Kirkman MS, 2012, DIABETES CARE, V35, P2650, DOI 10.2337/dc12-1801
   Liu BL, 2011, CELL CYCLE, V10, P2959, DOI 10.4161/cc.10.17.16359
   Marsland AL, 2015, BRAIN BEHAV IMMUN, V48, P195, DOI 10.1016/j.bbi.2015.03.015
   Martin-Montalvo A, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms3192
   Matt SM, 2018, FRONT IMMUNOL, V9, DOI 10.3389/fimmu.2018.01832
   Mau T, 2018, EXP GERONTOL, V105, P27, DOI 10.1016/j.exger.2017.10.014
   Moiseeva O, 2013, AGING CELL, V12, P489, DOI 10.1111/acel.12075
   Nagpal R, 2019, EBIOMEDICINE, V47, P529, DOI 10.1016/j.ebiom.2019.08.032
   Nagpal R, 2018, J DIABETES RES, V2018, DOI 10.1155/2018/3462092
   Nagpal Ravinder, 2018, Nutr Healthy Aging, V4, P267, DOI 10.3233/NHA-170030
   Noah TK, 2011, EXP CELL RES, V317, P2702, DOI 10.1016/j.yexcr.2011.09.006
   NUNESSOUZA V, 2016, OXID MED CELL LONGEV, V2016, DOI DOI 10.1155/2016/1987960
   Nunez Joseph, 2008, J Vis Exp, DOI 10.3791/897
   Ozawa M, 2017, CLIN NUTR, V36, P506, DOI 10.1016/j.clnu.2016.01.013
   Qi YF, 2017, J AM MED DIR ASSOC, V18, DOI 10.1016/j.jamda.2017.05.018
   Rehman Tayyab, 2012, Endocrine Metabolic & Immune Disorders-Drug Targets, V12, P361
   Robinson K, 2015, FRONT VET SCI, V2, DOI 10.3389/fvets.2015.00057
   Sakamoto K, 2013, J DIABETES INVEST, V4, P552, DOI 10.1111/jdi.12096
   Sansom OJ, 2004, GENE DEV, V18, P1385, DOI 10.1101/gad.287404
   Sartori AC, 2012, J NEUROSCI NURS, V44, P206, DOI 10.1097/JNN.0b013e3182527690
   Scott KA, 2017, BRAIN BEHAV IMMUN, V65, P20, DOI 10.1016/j.bbi.2017.02.004
   Simpson RJ, 2016, BRAIN BEHAV IMMUN, V56, P10, DOI 10.1016/j.bbi.2016.05.015
   Song YM, 2015, AUTOPHAGY, V11, P46, DOI 10.4161/15548627.2014.984271
   Sovran B, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-018-35228-3
   Stehle JR, 2012, J GERONTOL A-BIOL, V67, P1212, DOI 10.1093/gerona/gls178
   Sundman MH, 2017, BRAIN BEHAV IMMUN, V66, P31, DOI 10.1016/j.bbi.2017.05.009
   Thevaranjan N, 2017, CELL HOST MICROBE, V21, P455, DOI 10.1016/j.chom.2017.03.002
   Turner JR, 2009, NAT REV IMMUNOL, V9, P799, DOI 10.1038/nri2653
   Urios A, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-53136-y
   van der Lugt B, 2019, IMMUN AGEING, V16, DOI 10.1186/s12979-019-0145-z
   Whang A, 2019, EBIOMEDICINE, V39, P591, DOI 10.1016/j.ebiom.2018.11.046
   Yadav H., 2016, METABOLOMICS, V6, pe150
   Yadav H, 2011, CELL METAB, V14, P67, DOI 10.1016/j.cmet.2011.04.013
   Zhang WH, 2019, J AM GERIATR SOC, V67, P381, DOI 10.1111/jgs.15660
   Zheng Z, 2012, DIABETES, V61, P217, DOI 10.2337/db11-0416
NR 58
TC 59
Z9 60
U1 1
U2 20
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1079-5006
EI 1758-535X
J9 J GERONTOL A-BIOL
JI J. Gerontol. Ser. A-Biol. Sci. Med. Sci.
PD JUL
PY 2020
VL 75
IS 7
SI SI
BP E9
EP E21
DI 10.1093/gerona/glaa056
PG 13
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA OD4YV
UT WOS:000579859200002
PM 32129462
OA Green Published, Bronze
DA 2023-06-08
ER

PT J
AU Foretz, M
   Guigas, B
   Viollet, B
AF Foretz, Marc
   Guigas, Bruno
   Viollet, Benoit
TI Understanding the glucoregulatory mechanisms of metformin in type 2
   diabetes mellitus
SO NATURE REVIEWS ENDOCRINOLOGY
LA English
DT Review
ID GLUCAGON-LIKE PEPTIDE-1; POLYCYSTIC-OVARY-SYNDROME; HEPATIC
   GLUCOSE-PRODUCTION; ACTIVATED PROTEIN-KINASE; REGULATORY T-CELLS;
   MITOCHONDRIAL PERMEABILITY TRANSITION; LIFE-STYLE MODIFICATION;
   INSULIN-RESISTANCE; OBESE-PATIENTS; CLINICAL PHARMACOKINETICS
AB Despite its position as the first-line drug for treatment of type 2 diabetes mellitus, the mechanisms underlying the plasma glucose level-lowering effects of metformin (1,1-dimethylbiguanide) still remain incompletely understood. Metformin is thought to exert its primary antidiabetic action through the suppression of hepatic glucose production. In addition, the discovery that metformin inhibits the mitochondrial respiratory chain complex 1 has placed energy metabolism and activation of AMP-activated protein kinase (AMPK) at the centre of its proposed mechanism of action. However, the role of AMPK has been challenged and might only account for indirect changes in hepatic insulin sensitivity. Various mechanisms involving alterations in cellular energy charge, AMP-mediated inhibition of adenylate cyclase or fructose-1,6-bisphosphatase 1 and modulation of the cellular redox state through direct inhibition of mitochondrial glycerol-3-phosphate dehydrogenase have been proposed for the acute inhibition of gluconeogenesis by metformin. Emerging evidence suggests that metformin could improve obesity-induced meta-inflammation via direct and indirect effects on tissue-resident immune cells in metabolic organs (that is, adipose tissue, the gastrointestinal tract and the liver). Furthermore, the gastrointestinal tract also has a major role in metformin action through modulation of glucose-lowering hormone glucagon-like peptide 1 and the intestinal bile acid pool and alterations in gut microbiota composition.
C1 [Foretz, Marc; Viollet, Benoit] INSERM, U1016, Inst Cochin, Paris, France.
   [Foretz, Marc; Viollet, Benoit] CNRS, UMR8104, Paris, France.
   [Foretz, Marc; Viollet, Benoit] Univ Paris 05, Sorbonne Paris Cite, Paris, France.
   [Guigas, Bruno] Leiden Univ, Med Ctr, Dept Parasitol, Leiden, Netherlands.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   UDICE-French Research Universities; Universite Paris Cite; Centre
   National de la Recherche Scientifique (CNRS); CNRS - National Institute
   for Biology (INSB); UDICE-French Research Universities; Universite Paris
   Cite; UDICE-French Research Universities; Universite Paris Cite; Leiden
   University; Leiden University Medical Center (LUMC); Leiden University -
   Excl LUMC
RP Viollet, B (通讯作者)，INSERM, U1016, Inst Cochin, Paris, France.; Viollet, B (通讯作者)，CNRS, UMR8104, Paris, France.; Viollet, B (通讯作者)，Univ Paris 05, Sorbonne Paris Cite, Paris, France.
EM benoit.viollet@inserm.fr
RI Viollet, Benoit/O-6927-2017; FORETZ, Marc/O-7334-2017; Viollet,
   Benoit/N-2397-2019; Guigas, Bruno/M-2515-2015
OI Viollet, Benoit/0000-0002-0121-0224; FORETZ, Marc/0000-0001-7017-9032;
   Viollet, Benoit/0000-0002-0121-0224; Guigas, Bruno/0000-0002-8856-5799
FU Inserm; CNRS; Universite Paris Descartes; Agence Nationale de la
   Recherche (ANR); Societe Francophone du Diabete (SFD); Fondation pour la
   Recherche Medicale (FRM); Dutch Organization for Scientific Research
   (ZonMW); DiabetesFonds
FX The authors acknowledge the support of grants from Inserm, CNRS,
   Universite Paris Descartes, Agence Nationale de la Recherche (ANR),
   Societe Francophone du Diabete (SFD), Fondation pour la Recherche
   Medicale (FRM), the Dutch Organization for Scientific Research (ZonMW)
   and DiabetesFonds.
CR ADASHI EY, 1981, ENDOCRINOLOGY, V108, P1441, DOI 10.1210/endo-108-4-1441
   Ait-Omar A, 2011, DIABETES, V60, P2598, DOI 10.2337/db10-1740
   Al-Oanzi ZH, 2017, DIABETES OBES METAB, V19, P1078, DOI 10.1111/dom.12910
   Alshawi A, 2019, J BIOL CHEM, V294, P2839, DOI 10.1074/jbc.RA118.006670
   Andrzejewski S, 2014, CANCER METAB, V2, DOI 10.1186/2049-3002-2-12
   Anisimov VN, 2008, CELL CYCLE, V7, P2769, DOI 10.4161/cc.7.17.6625
   Arai M, 2010, J PHARMACOL EXP THER, V334, P206, DOI 10.1124/jpet.109.164970
   Bahne E, 2018, JCI INSIGHT, V3, DOI 10.1172/jci.insight.93936
   Bahne E, 2016, DIABETES OBES METAB, V18, P955, DOI 10.1111/dom.12697
   Bailey CJ, 2008, DIABETOLOGIA, V51, P1552, DOI 10.1007/s00125-008-1053-5
   BAILEY CJ, 1994, BRIT J PHARMACOL, V112, P671, DOI 10.1111/j.1476-5381.1994.tb13128.x
   BAILEY CJ, 1992, BRIT J PHARMACOL, V105, P1009, DOI 10.1111/j.1476-5381.1992.tb09093.x
   Bailey CJ, 2017, DIABETOLOGIA, V60, P1566, DOI 10.1007/s00125-017-4318-z
   Balen AH, 2016, HUM REPROD UPDATE, V22, P687, DOI 10.1093/humupd/dmw025
   Barzilai N, 2016, CELL METAB, V23, P1060, DOI 10.1016/j.cmet.2016.05.011
   Bauer PV, 2018, CELL METAB, V27, P101, DOI 10.1016/j.cmet.2017.09.019
   Baur JA, 2014, CELL METAB, V20, P197, DOI 10.1016/j.cmet.2014.07.013
   Belkaid Y, 2017, IMMUNITY, V46, P562, DOI 10.1016/j.immuni.2017.04.008
   Berstein LM, 2018, EXPERT REV ENDOCRINO, V13, P63, DOI 10.1080/17446651.2018.1431123
   Bonnet F, 2017, DIABETES OBES METAB, V19, P473, DOI 10.1111/dom.12854
   BONORA E, 1984, CURR MED RES OPIN, V9, P47, DOI 10.1185/03007998409109558
   Borg MJ, 2019, DIABETES OBES METAB, V21, P640, DOI 10.1111/dom.13567
   Bouchoucha M, 2011, DIABETES METAB, V37, P90, DOI 10.1016/j.diabet.2010.11.002
   Boudaba N, 2018, EBIOMEDICINE, V28, P194, DOI 10.1016/j.ebiom.2018.01.008
   Boukalova S, 2016, MOL CANCER THER, V15, P2875, DOI 10.1158/1535-7163.MCT-15-1021
   Brestoff JR, 2015, CELL, V161, P146, DOI 10.1016/j.cell.2015.02.022
   Bridges HR, 2016, BMC BIOL, V14, DOI 10.1186/s12915-016-0287-9
   Bridges HR, 2014, BIOCHEM J, V462, P475, DOI 10.1042/BJ20140620
   Brisson D, 2001, BIOESSAYS, V23, P534, DOI 10.1002/bies.1073
   Bronden A, 2017, J CLIN ENDOCR METAB, V102, P4153, DOI 10.1210/jc.2017-01091
   Buck MD, 2017, CELL, V169, P570, DOI 10.1016/j.cell.2017.04.004
   Buldak L, 2014, PHARMACOL REP, V66, P418, DOI 10.1016/j.pharep.2013.11.008
   Burton Jeffrey H, 2015, J Diabetes Sci Technol, V9, P808, DOI 10.1177/1932296815577425
   Buse JB, 2016, DIABETES CARE, V39, P198, DOI 10.2337/dc15-0488
   Cabreiro F, 2013, CELL, V153, P228, DOI 10.1016/j.cell.2013.02.035
   Cai DS, 2005, NAT MED, V11, P183, DOI 10.1038/nm1166
   Cameron AR, 2016, CIRC RES, V119, P652, DOI 10.1161/CIRCRESAHA.116.308445
   Cani PD, 2009, AM J CLIN NUTR, V90, P1236, DOI 10.3945/ajcn.2009.28095
   Cao J, 2014, J BIOL CHEM, V289, P20435, DOI 10.1074/jbc.M114.567271
   Carmina E, 1999, HUM REPROD, V14, P307, DOI 10.1093/humrep/14.2.307
   Carmina E, 2004, FERTIL STERIL, V82, P661, DOI 10.1016/j.fertnstert.2004.01.041
   Carter D, 2003, DIABETES OBES METAB, V5, P120, DOI 10.1046/j.1463-1326.2003.00252.x
   Caton PW, 2010, J ENDOCRINOL, V205, P97, DOI 10.1677/JOE-09-0345
   Cetin M, 2016, DRUG DELIV, V23, P2796, DOI 10.3109/10717544.2015.1089957
   Chambers ES, 2015, GUT, V64, P1744, DOI 10.1136/gutjnl-2014-307913
   Cheng G, 2016, CANCER RES, V76, P3904, DOI 10.1158/0008-5472.CAN-15-2534
   Christensen MMH, 2011, PHARMACOGENET GENOM, V21, P837, DOI 10.1097/FPC.0b013e32834c0010
   Clarke JD, 2015, DIABETES, V64, P3305, DOI 10.2337/db14-1947
   Cokorinos EC, 2017, CELL METAB, V25, P1147, DOI 10.1016/j.cmet.2017.04.010
   Cool B, 2006, CELL METAB, V3, P403, DOI 10.1016/j.cmet.2006.05.005
   Cote CD, 2015, NAT MED, V21, P498, DOI 10.1038/nm.3821
   Cusi K, 1996, J CLIN ENDOCR METAB, V81, P4059, DOI 10.1210/jc.81.11.4059
   Davies MJ, 2018, DIABETOLOGIA, V61, P2461, DOI [10.1007/s00125-018-4729-5, 10.2337/dci18-0033]
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   de Oliveira S, 2019, J HEPATOL, V70, P710, DOI 10.1016/j.jhep.2018.11.034
   De Vadder F, 2014, CELL, V156, P84, DOI 10.1016/j.cell.2013.12.016
   DEFRONZO RA, 1991, J CLIN ENDOCR METAB, V73, P1294, DOI 10.1210/jcem-73-6-1294
   DeFronzo RA, 2016, DIABETOLOGIA, V59, P1645, DOI 10.1007/s00125-016-3992-6
   Degner NR, 2018, CLIN INFECT DIS, V66, P198, DOI 10.1093/cid/cix819
   Depommier C, 2019, NAT MED, V25, P1096, DOI 10.1038/s41591-019-0495-2
   Detaille D, 2005, DIABETES, V54, P2179, DOI 10.2337/diabetes.54.7.2179
   Detaille D, 2002, BIOCHEM PHARMACOL, V63, P1259, DOI 10.1016/S0006-2952(02)00858-4
   Duca FA, 2015, CELL METAB, V22, P367, DOI 10.1016/j.cmet.2015.07.003
   Duca FA, 2015, NAT MED, V21, P506, DOI 10.1038/nm.3787
   Dujic T, 2017, CLIN PHARMACOL THER, V101, P763, DOI 10.1002/cpt.567
   Dujic T, 2016, DIABETES CARE, V39, P1896, DOI 10.2337/dc16-0706
   Dujic T, 2015, DIABETES, V64, P1786, DOI 10.2337/db14-1388
   Eikawa S, 2015, P NATL ACAD SCI USA, V112, P1809, DOI 10.1073/pnas.1417636112
   El-Mir MY, 2008, J MOL NEUROSCI, V34, P77, DOI 10.1007/s12031-007-9002-1
   El-Mir MY, 2000, J BIOL CHEM, V275, P223, DOI 10.1074/jbc.275.1.223
   Elbere I, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0204317
   Escobar-Morreale HF, 2018, NAT REV ENDOCRINOL, V14, P270, DOI 10.1038/nrendo.2018.24
   Esposti MD, 1998, BBA-BIOENERGETICS, V1364, P222, DOI 10.1016/S0005-2728(98)00029-2
   Esquejo RM, 2018, EBIOMEDICINE, V31, P122, DOI 10.1016/j.ebiom.2018.04.009
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Feuerer M, 2009, NAT MED, V15, P930, DOI 10.1038/nm.2002
   Fidan E, 2011, ACTA DIABETOL, V48, P297, DOI 10.1007/s00592-011-0276-y
   Fontaine E, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00753
   Fontaine Eric, 2014, Biochem J, V463, pe3, DOI 10.1042/BJ20141020
   Foretz M, 2014, CELL METAB, V20, P953, DOI 10.1016/j.cmet.2014.09.018
   Foretz M, 2010, J CLIN INVEST, V120, P2355, DOI 10.1172/JCI40671
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Fujita Y, 2017, CURR DIABETES REP, V17, DOI 10.1007/s11892-017-0829-8
   Fullerton MD, 2013, NAT MED, V19, P1649, DOI 10.1038/nm.3372
   Geltink RIK, 2018, ANNU REV IMMUNOL, V36, P461, DOI 10.1146/annurev-immunol-042617-053019
   GIBSON GR, 1995, J NUTR, V125, P1401, DOI 10.1093/jn/125.6.1401
   Gontier E, 2008, EUR J NUCL MED MOL I, V35, P95, DOI 10.1007/s00259-007-0563-6
   Gormsen LC, 2016, J NUCL MED, V57, P1920, DOI 10.2967/jnumed.116.177774
   Graham GG, 2011, CLIN PHARMACOKINET, V50, P81, DOI 10.2165/11534750-000000000-00000
   Greenway F, 2014, BENEF MICROBES, V5, P29, DOI 10.3920/BM2012.0063
   Gui DY, 2016, CELL METAB, V24, P716, DOI 10.1016/j.cmet.2016.09.006
   Guigas B, 2004, BIOCHEM J, V382, P877, DOI 10.1042/BJ20040885
   Guo ZJ, 2017, CELL CHEM BIOL, V24, P1314, DOI 10.1016/j.chembiol.2017.09.012
   Hansen M, 2016, DIABETES OBES METAB, V18, P571, DOI 10.1111/dom.12648
   Hardie DG, 2014, CELL METAB, V20, P939, DOI 10.1016/j.cmet.2014.09.013
   Hawley SA, 2010, CELL METAB, V11, P554, DOI 10.1016/j.cmet.2010.04.001
   He L, 2015, CELL METAB, V21, P159, DOI 10.1016/j.cmet.2015.01.003
   He L, 2009, CELL, V137, P635, DOI 10.1016/j.cell.2009.03.016
   Heckman-Stoddard BM, 2017, DIABETOLOGIA, V60, P1639, DOI 10.1007/s00125-017-4372-6
   Henry RR, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0203946
   Hirst J, 2013, ANNU REV BIOCHEM, V82, P551, DOI 10.1146/annurev-biochem-070511-103700
   Hoffmann Irene S, 2003, Am J Ther, V10, P447, DOI 10.1097/00045391-200311000-00012
   HOLLUNGER G, 1955, Acta Pharmacol Toxicol (Copenh), V11, P1
   Hotamisligil GS, 2017, NATURE, V542, P177, DOI 10.1038/nature21363
   HOTHERNIELSEN O, 1989, ACTA ENDOCRINOL-COP, V120, P257, DOI 10.1530/acta.0.1200257
   Howlett HCS, 1999, DRUG SAFETY, V20, P489, DOI 10.2165/00002018-199920060-00003
   Huang W, 2010, DIABETES, V59, P347, DOI 10.2337/db09-0016
   Hundal RS, 2000, DIABETES, V49, P2063, DOI 10.2337/diabetes.49.12.2063
   Hunter RW, 2018, NAT MED, V24, P1395, DOI 10.1038/s41591-018-0159-7
   Ikeda T, 2000, BIOCHEM PHARMACOL, V59, P887, DOI 10.1016/S0006-2952(99)00396-2
   Ilan Y, 2010, P NATL ACAD SCI USA, V107, P9765, DOI 10.1073/pnas.0908771107
   Inzucchi SE, 1998, NEW ENGL J MED, V338, P867, DOI 10.1056/NEJM199803263381303
   Jablonski KA, 2010, DIABETES, V59, P2672, DOI 10.2337/db10-0543
   Jensen JB, 2016, DIABETES, V65, P1724, DOI 10.2337/db16-0032
   Jing YY, 2018, MOL CELL ENDOCRINOL, V461, P256, DOI 10.1016/j.mce.2017.09.025
   Justice JN, 2018, GEROSCIENCE, V40, P419, DOI 10.1007/s11357-018-0042-y
   Kang K, 2008, CELL METAB, V7, P485, DOI 10.1016/j.cmet.2008.04.002
   Kappe C, 2013, J GASTROENTEROL, V48, P322, DOI 10.1007/s00535-012-0637-5
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kashyap S, 2004, HUM REPROD, V19, P2474, DOI 10.1093/humrep/deh440
   Kelly B, 2015, J BIOL CHEM, V290, P20348, DOI 10.1074/jbc.M115.662114
   Kim J, 2014, J BIOL CHEM, V289, P23246, DOI 10.1074/jbc.M114.577908
   Kim MH, 2014, J ENDOCRINOL, V220, P117, DOI 10.1530/JOE-13-0381
   Koffert JP, 2017, DIABETES RES CLIN PR, V131, P208, DOI 10.1016/j.diabres.2017.07.015
   Kuhre RE, 2015, DIABETES, V64, P370, DOI 10.2337/db14-0807
   Kunisada Y, 2017, EBIOMEDICINE, V25, P154, DOI 10.1016/j.ebiom.2017.10.009
   Kurelac I, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-08839-1
   Lackey DE, 2016, NAT REV ENDOCRINOL, V12, P15, DOI 10.1038/nrendo.2015.189
   Lalau JD, 2011, CLIN DRUG INVEST, V31, P435, DOI 10.2165/11588310-000000000-00000
   Lanthier N, 2010, AM J PHYSIOL-GASTR L, V298, pG107, DOI 10.1152/ajpgi.00391.2009
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Lee JM, 2010, J BIOL CHEM, V285, P32182, DOI 10.1074/jbc.M110.134890
   Lee SY, 2017, J IMMUNOL, V198, P2661, DOI 10.4049/jimmunol.1403088
   Lee SY, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0135858
   LEE YP, 1965, J BIOL CHEM, V240, P1427
   Legro RS, 2007, NEW ENGL J MED, V356, P551, DOI 10.1056/NEJMoa063971
   Lenzen S, 1996, BIOCHEM PHARMACOL, V51, P893, DOI 10.1016/0006-2952(95)02243-0
   Li LF, 2018, CANCER RES, V78, P1779, DOI 10.1158/0008-5472.CAN-17-2460
   Li MQ, 2019, CELL METAB, V30, P508, DOI 10.1016/j.cmet.2019.05.018
   Li MX, 2017, MEDICINE, V96, DOI 10.1097/MD.0000000000008161
   Liang XM, 2017, J PHARM SCI-US, V106, P2245, DOI 10.1016/j.xphs.2017.04.078
   Lien F, 2014, J CLIN INVEST, V124, P1037, DOI 10.1172/JCI68815
   LIN ECC, 1977, ANNU REV BIOCHEM, V46, P765, DOI 10.1146/annurev.bi.46.070177.004001
   Logie L, 2012, DIABETES, V61, P1423, DOI 10.2337/db11-0961
   Evia-Viscarra ML, 2012, J PEDIATR ENDOCR MET, V25, P41, DOI 10.1515/jpem-2011-0469
   Lu CH, 2016, EUR J PHARMACOL, V789, P60, DOI 10.1016/j.ejphar.2016.07.012
   Lumeng CN, 2007, J CLIN INVEST, V117, P175, DOI 10.1172/JCI29881
   Lund SS, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003363
   Madiraju AK, 2018, NAT MED, V24, P1384, DOI 10.1038/s41591-018-0125-4
   Madiraju AK, 2014, NATURE, V510, P542, DOI 10.1038/nature13270
   Maida A, 2011, DIABETOLOGIA, V54, P339, DOI 10.1007/s00125-010-1937-z
   Maier L, 2018, NATURE, V555, P623, DOI 10.1038/nature25979
   Mannucci E, 2004, DIABETES NUTR METAB, V17, P336
   Maruthur NM, 2016, ANN INTERN MED, V164, P740, DOI 10.7326/M15-2650
   Mazza A, 2012, EXP DIABETES RES, DOI 10.1155/2012/716404
   McCreight LJ, 2018, DIABETES OBES METAB, V20, P1593, DOI 10.1111/dom.13264
   McCreight LJ, 2016, DIABETOLOGIA, V59, P426, DOI 10.1007/s00125-015-3844-9
   McDole JR, 2012, NATURE, V483, P345, DOI 10.1038/nature10863
   McNelis JC, 2014, IMMUNITY, V41, P36, DOI 10.1016/j.immuni.2014.05.010
   Meng HY, 2018, DIABETES-METAB RES, V34, DOI 10.1002/dmrr.2983
   Miller RA, 2013, NATURE, V494, P256, DOI 10.1038/nature11808
   Moiseeva O, 2013, AGING CELL, V12, P489, DOI 10.1111/acel.12075
   Morin-Papunen L, 2003, J CLIN ENDOCR METAB, V88, P4649, DOI 10.1210/jc.2002-021688
   Morley Lara C, 2017, Cochrane Database Syst Rev, V11, pCD003053, DOI 10.1002/14651858.CD003053.pub6
   Mulherin AJ, 2011, ENDOCRINOLOGY, V152, P4610, DOI 10.1210/en.2011-1485
   Naderpoor N, 2015, HUM REPROD UPDATE, V21, P560, DOI 10.1093/humupd/dmv025
   Napolitano A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100778
   Natali A, 2006, DIABETOLOGIA, V49, P434, DOI 10.1007/s00125-006-0141-7
   NATTRASS M, 1978, DIABETES METAB, V4, P1
   Negrotto L, 2016, JAMA NEUROL, V73, P520, DOI 10.1001/jamaneurol.2015.4807
   Nestler JE, 1998, J CLIN ENDOCR METAB, V83, P2001, DOI 10.1210/jc.83.6.2001
   Nestler JE, 1998, NEW ENGL J MED, V338, P1876, DOI 10.1056/NEJM199806253382603
   Odegaard JI, 2008, CELL METAB, V7, P496, DOI 10.1016/j.cmet.2008.04.003
   Odegaard JI, 2007, NATURE, V447, P1116, DOI 10.1038/nature05894
   Oh J, 2016, DIABETES OBES METAB, V18, P104, DOI 10.1111/dom.12577
   Orio F, 2005, J CLIN ENDOCR METAB, V90, P6072, DOI 10.1210/jc.2005-0965
   Ovalle F, 2002, FERTIL STERIL, V77, P1095, DOI 10.1016/S0015-0282(02)03111-4
   Owen MR, 2000, BIOCHEM J, V348, P607, DOI 10.1042/0264-6021:3480607
   Palmer SC, 2016, JAMA-J AM MED ASSOC, V316, P313, DOI 10.1001/jama.2016.9400
   Parker HE, 2012, DIABETOLOGIA, V55, P2445, DOI 10.1007/s00125-012-2585-2
   PENICAUD L, 1989, BIOCHEM J, V262, P881, DOI 10.1042/bj2620881
   Pereira Felipe V, 2018, Oncotarget, V9, P25808, DOI 10.18632/oncotarget.25380
   Petrie JR, 2017, LANCET DIABETES ENDO, V5, P597, DOI 10.1016/S2213-8587(17)30194-8
   Plovier H, 2017, NAT MED, V23, P107, DOI 10.1038/nm.4236
   Postler TS, 2017, CELL METAB, V26, P110, DOI 10.1016/j.cmet.2017.05.008
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Rangarajan S, 2018, NAT MED, V24, P1121, DOI 10.1038/s41591-018-0087-6
   Ricardo-Gonzalez RR, 2010, P NATL ACAD SCI USA, V107, P22617, DOI 10.1073/pnas.1009152108
   Ridlon JM, 2006, J LIPID RES, V47, P241, DOI 10.1194/jlr.R500013-JLR200
   RINGLER RL, 1959, J BIOL CHEM, V234, P2211
   Rosario D, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.00775
   Rotermund C, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00400
   Saheki T, 2007, J BIOL CHEM, V282, P25041, DOI 10.1074/jbc.M702031200
   Sakar Y, 2010, J PHYSIOL PHARMACOL, V61, P301
   Sanchez-Rangel E, 2017, DIABETOLOGIA, V60, P1586, DOI 10.1007/s00125-017-4336-x
   Sato N, 2016, RESP RES, V17, DOI 10.1186/s12931-016-0420-x
   Scarpello JHB, 1998, DIABETIC MED, V15, P651, DOI 10.1002/(SICI)1096-9136(199808)15:8<651::AID-DIA628>3.0.CO;2-A
   SCHAFER G, 1969, BIOCHIM BIOPHYS ACTA, V172, P334, DOI 10.1016/0005-2728(69)90077-2
   Scheen AJ, 1996, CLIN PHARMACOKINET, V30, P359, DOI 10.2165/00003088-199630050-00003
   Scheen AJ, 2016, EXPERT OPIN PHARMACO, V17, P627, DOI 10.1517/14656566.2016.1149166
   Shaw RJ, 2005, SCIENCE, V310, P1642, DOI 10.1126/science.1120781
   Shen CL, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-29063-9
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Shu Y, 2007, J CLIN INVEST, V117, P1422, DOI 10.1172/JCI30558
   Singhal A, 2014, SCI TRANSL MED, V6, DOI 10.1126/scitranslmed.3009885
   Solorzano CMB, 2012, STEROIDS, V77, P332, DOI 10.1016/j.steroids.2011.12.007
   Son HJ, 2014, MEDIAT INFLAMM, V2014, DOI 10.1155/2014/973986
   Stanya KJ, 2013, J CLIN INVEST, V123, P261, DOI 10.1172/JCI64941
   Stepensky D, 2002, DRUG METAB DISPOS, V30, P861, DOI 10.1124/dmd.30.8.861
   Stephenne X, 2011, DIABETOLOGIA, V54, P3101, DOI 10.1007/s00125-011-2311-5
   Stienstra R, 2017, CELL METAB, V26, P142, DOI 10.1016/j.cmet.2017.06.001
   STUMVOLL M, 1995, NEW ENGL J MED, V333, P550, DOI 10.1056/NEJM199508313330903
   SUM CF, 1992, DIABETIC MED, V9, P61, DOI 10.1111/j.1464-5491.1992.tb01716.x
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Talukdar S, 2012, NAT MED, V18, P1407, DOI 10.1038/nm.2885
   Tang T, 2006, HUM REPROD, V21, P80, DOI 10.1093/humrep/dei311
   Tang T, 2003, COCHRANE DB SYST REV, DOI [10.1002/14651858.CD003053, DOI 10.1002/14651858.CD003053]
   Thakur S, 2018, CLIN CANCER RES, V24, P4030, DOI 10.1158/1078-0432.CCR-17-3167
   Thomas C, 2009, CELL METAB, V10, P167, DOI 10.1016/j.cmet.2009.08.001
   Todd JN, 2014, PHARMACOGENOMICS, V15, P529, DOI [10.2217/PGS.14.21, 10.2217/pgs.14.21]
   Tong XL, 2018, MBIO, V9, DOI 10.1128/mBio.02392-17
   Tosi F, 2011, EUR J ENDOCRINOL, V164, P197, DOI 10.1530/EJE-10-0782
   Trabelsi MS, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms8629
   TUCKER GT, 1981, BRIT J CLIN PHARMACO, V12, P235
   Turner RC, 1998, LANCET, V352, P854, DOI 10.1016/s0140-6736(98)07037-8
   Vasamsetti SB, 2015, DIABETES, V64, P2028, DOI 10.2337/db14-1225
   Vashisht R, 2015, J TRANSL MED, V13, DOI 10.1186/s12967-015-0443-y
   Vial G, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00294
   Waise TMZ, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-08582-7
   Waise TMZ, 2018, NAT REV GASTRO HEPAT, V15, P625, DOI 10.1038/s41575-018-0062-1
   Walker J, 2005, BIOCHEM J, V385, P485, DOI 10.1042/BJ20040694
   Weisman A, 2017, LANCET DIABETES ENDO, V5, P501, DOI 10.1016/S2213-8587(17)30167-5
   Werner EA, 1922, J CHEM SOC, V121, P1790, DOI 10.1039/ct9222101790
   Wheaton WW, 2014, ELIFE, V3, DOI 10.7554/eLife.02242
   WILCOCK C, 1991, J PHARM PHARMACOL, V43, P442, DOI 10.1111/j.2042-7158.1991.tb03507.x
   WILCOCK C, 1994, XENOBIOTICA, V24, P49, DOI 10.3109/00498259409043220
   Wild RA, 2010, J CLIN ENDOCR METAB, V95, P2038, DOI 10.1210/jc.2009-2724
   Wood JR, 2013, DIABETES CARE, V36, P2035, DOI 10.2337/dc12-1959
   Wright A, 1998, ANN INTERN MED, V128, P165, DOI 10.7326/0003-4819-128-3-199802010-00001
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Wu T, 2013, DIABETES OBES METAB, V15, P474, DOI 10.1111/dom.12043
   Wu TZ, 2017, EXPERT REV GASTROENT, V11, P157, DOI 10.1080/17474124.2017.1273769
   Wu TZ, 2017, DIABETES OBES METAB, V19, P290, DOI 10.1111/dom.12812
   Xue WH, 2018, CELL PHYSIOL BIOCHEM, V45, P2461, DOI 10.1159/000488264
   Yan Z, 2018, MOL MED, V24, DOI 10.1186/s10020-018-0013-x
   Zannella VE, 2013, CLIN CANCER RES, V19, P6741, DOI 10.1158/1078-0432.CCR-13-1787
   Zhang CS, 2016, CELL METAB, V24, P521, DOI 10.1016/j.cmet.2016.09.003
   Zhang CS, 2014, CELL METAB, V20, P526, DOI 10.1016/j.cmet.2014.06.014
   Zhang XQ, 2015, SCI REP-UK, V5, DOI 10.1038/srep10737
   Zhao Y, 2016, NAT COMMUN, V7, DOI 10.1038/ncomms11822
   Zhou GC, 2001, J CLIN INVEST, V108, P1167, DOI 10.1172/JCI200113505
   Zhou KX, 2016, NAT GENET, V48, P1055, DOI 10.1038/ng.3632
   Zickermann V, 2015, SCIENCE, V347, P44, DOI 10.1126/science.1259859
NR 253
TC 265
Z9 278
U1 22
U2 204
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 1759-5029
EI 1759-5037
J9 NAT REV ENDOCRINOL
JI Nat. Rev. Endocrinol.
PD OCT
PY 2019
VL 15
IS 10
BP 569
EP 589
DI 10.1038/s41574-019-0242-2
PG 21
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA IX4KE
UT WOS:000485654300008
PM 31439934
OA Green Submitted
HC Y
HP N
DA 2023-06-08
ER

PT J
AU Dahabiyeh, LA
   Mujammami, M
   Arafat, T
   Benabdelkamel, H
   Alfadda, AA
   Rahman, AMA
AF Dahabiyeh, Lina A.
   Mujammami, Muhammad
   Arafat, Tawfiq
   Benabdelkamel, Hicham
   Alfadda, Assim A.
   Rahman, Anas M. Abdel
TI A Metabolic Pattern in Healthy Subjects Given a Single Dose of
   Metformin: A Metabolomics Approach
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE metabolomics; metformin; branched-chain amino acids; mass spectrometry;
   glycerophospholipid; eicosanoids; type 2 diabetes mellitus; cancer
ID P-COUMARIC ACID; MECHANISMS; HYPERGLYCEMIA; INFLAMMATION; MODULATION;
   CONTRIBUTE; GROWTH
AB Metformin is a widely prescribed medication for the treatment of type 2 diabetes mellitus (T2DM). It possesses effective roles in various disorders, including cancer, dyslipidemia, and obesity. However, the underlying mechanisms of metformin's multiple benefits are not fully understood. Herein, a mass spectrometry-based untargeted metabolomics approach was used to investigate the metabolic changes associated with the administration of a single dose of metformin in the plasma of 26 healthy subjects at five-time points; pre-dose, before the maximum concentration of metformin (C-max), C-max, after C-max, and 36 h post-dose. A total of 111 metabolites involved in various biochemical processes were perturbed, with branched-chain amino acid (BCAA) being the most significantly altered pathway. Additionally, the Pearson similarity test revealed that 63 metabolites showed a change in their levels dependent on metformin level. Out of these 63, the level of 36 metabolites was significantly altered by metformin. Significantly altered metformin-dependent metabolites, including hydroxymethyl uracil, propionic acid, glycerophospholipids, and eicosanoids, pointed to fundamental biochemical processes such as lipid network signaling, energy homeostasis, DNA lesion repair mechanisms, and gut microbiota functions that could be linked to the multiple beneficial roles of metformin. Thus, the distinctive metabolic pattern linked to metformin administration can be used as a metabolic signature to predict the potential effect and mechanism of actions of new chemical entities during drug development.
C1 [Dahabiyeh, Lina A.] Univ Jordan, Sch Pharm, Dept Pharmaceut Sci, Amman, Jordan.
   [Mujammami, Muhammad; Alfadda, Assim A.] King Saud Univ, Coll Med, Dept Med, Endocrinol & Diabet Unit, Riyadh, Saudi Arabia.
   [Mujammami, Muhammad] King Saud Univ, King Saud Univ Med City, Univ Diabet Ctr, Riyadh, Saudi Arabia.
   [Arafat, Tawfiq] Jordan Ctr Pharmaceut Res, Amman, Jordan.
   [Benabdelkamel, Hicham; Alfadda, Assim A.] King Saud Univ, Obes Res Ctr, Prote Resource Unit, Riyadh, Saudi Arabia.
   [Rahman, Anas M. Abdel] King Faisal Specialist Hosp & Res Ctr KFSHRC, Dept Clin Gen, Metabol Sect, Riyadh, Saudi Arabia.
   [Rahman, Anas M. Abdel] Al Faisal Univ, Coll Med, Dept Biochem & Mol Med, Riyadh, Saudi Arabia.
   [Rahman, Anas M. Abdel] Mem Univ Newfoundland, Dept Chem, St John, NF, Canada.
C3 University of Jordan; King Saud University; King Saud University; King
   Saud University; Alfaisal University; Memorial University Newfoundland
RP Dahabiyeh, LA (通讯作者)，Univ Jordan, Sch Pharm, Dept Pharmaceut Sci, Amman, Jordan.; Rahman, AMA (通讯作者)，King Faisal Specialist Hosp & Res Ctr KFSHRC, Dept Clin Gen, Metabol Sect, Riyadh, Saudi Arabia.; Rahman, AMA (通讯作者)，Al Faisal Univ, Coll Med, Dept Biochem & Mol Med, Riyadh, Saudi Arabia.; Rahman, AMA (通讯作者)，Mem Univ Newfoundland, Dept Chem, St John, NF, Canada.
EM l.dahabiyeh@ju.edu.jo; aabdelrahman46@kfshrc.edu.sa
RI Alfadda, Assim/AAF-4499-2020; benabdelkamel, hicham/GXV-1396-2022; Abdel
   Rahman, Anas/AEC-1515-2022
OI Abdel Rahman, Anas/0000-0002-9527-9424
FU University Diabetes Center, King Saud University Medical City, King Saud
   University
FX This research project was supported by the University Diabetes Center,
   King Saud University Medical City, King Saud University.
CR Abdel-Moneim A, 2018, BIOMED PHARMACOTHER, V105, P1091, DOI 10.1016/j.biopha.2018.06.096
   Adam J, 2016, DIABETES, V65, P3776, DOI 10.2337/db16-0512
   Al-Lahham SH, 2010, BBA-MOL CELL BIOL L, V1801, P1175, DOI 10.1016/j.bbalip.2010.07.007
   Alam MA, 2016, NUTR METAB, V13, DOI 10.1186/s12986-016-0080-3
   Aleidi SM, 2021, FRONT PHARMACOL, V11, DOI 10.3389/fphar.2020.616157
   Arneth B, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20102467
   Balashova EE, 2018, J PERS MED, V8, DOI 10.3390/jpm8030028
   Bao YQ, 2009, J PROTEOME RES, V8, P1623, DOI 10.1021/pr800643w
   Bonnefont-Rousselot D, 2003, METABOLISM, V52, P586, DOI 10.1053/meta.2003.50093
   Buse JB, 2020, DIABETES CARE, V43, P487, DOI 10.2337/dci19-0066
   Cameron AR, 2016, CIRC RES, V119, P652, DOI 10.1161/CIRCRESAHA.116.308445
   Chakrabarti SK, 2009, OBESITY, V17, P1657, DOI 10.1038/oby.2009.192
   Chong J, 2018, NUCLEIC ACIDS RES, V46, pW486, DOI 10.1093/nar/gky310
   Cooke MS, 2003, FASEB J, V17, P1195, DOI 10.1096/fj.02-0752rev
   Dahabiyeh LA, 2021, BIOMOLECULES, V11, DOI 10.3390/biom11030364
   Dahabiyeh LA, 2020, METABOLITES, V10, DOI 10.3390/metabo10020042
   Davies MJ, 2018, DIABETOLOGIA, V61, P2461, DOI [10.1007/s00125-018-4729-5, 10.2337/dci18-0033]
   Dennis EA, 2015, NAT REV IMMUNOL, V15, P511, DOI 10.1038/nri3859
   Dolce Vincenza, 2011, Curr Mol Pharmacol, V4, P167
   Foretz M, 2019, NAT REV ENDOCRINOL, V15, P569, DOI 10.1038/s41574-019-0242-2
   Foretz M, 2014, CELL METAB, V20, P953, DOI 10.1016/j.cmet.2014.09.018
   Gu XY, 2020, FRONT MOL BIOSCI, V7, DOI 10.3389/fmolb.2020.609806
   Guadarrama-Lopez AL, 2014, J IMMUNOL RES, V2014, DOI 10.1155/2014/860703
   Guasch-Ferre M, 2016, DIABETES CARE, V39, P833, DOI 10.2337/dc15-2251
   Houten SM, 2010, J INHERIT METAB DIS, V33, P469, DOI 10.1007/s10545-010-9061-2
   Hu JW, 2020, J CANCER, V11, P6437, DOI 10.7150/jca.47532
   Hyun Bobae, 2013, Immune Netw, V13, P123, DOI 10.4110/in.2013.13.4.123
   Iranshahy M, 2019, EUR J PHARMACOL, V850, P1, DOI 10.1016/j.ejphar.2019.02.004
   Jacob M, 2019, MASS SPECTROM REV, V38, P221, DOI 10.1002/mas.21548
   Kane DA, 2010, FREE RADICAL BIO MED, V49, P1082, DOI 10.1016/j.freeradbiomed.2010.06.022
   Koves TR, 2008, CELL METAB, V7, P45, DOI 10.1016/j.cmet.2007.10.013
   KUHAJDA FP, 1994, P NATL ACAD SCI USA, V91, P6379, DOI 10.1073/pnas.91.14.6379
   Lazar V, 2019, FRONT NUTR, V6, DOI 10.3389/fnut.2019.00021
   Liu XJ, 2016, CELL METAB, V24, P728, DOI 10.1016/j.cmet.2016.09.005
   Ma X, 2017, AMINO ACIDS, V49, P957, DOI 10.1007/s00726-017-2399-0
   Mai M, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0082459
   Malkawi AK, 2018, FRONT PHARMACOL, V9, DOI 10.3389/fphar.2018.00046
   Maurice CF, 2013, CELL, V152, P39, DOI 10.1016/j.cell.2012.10.052
   Menendez JA, 2007, NAT REV CANCER, V7, P763, DOI 10.1038/nrc2222
   Nie CX, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19040954
   Olinski R, 2016, MUTAT RES-REV MUTAT, V767, P59, DOI 10.1016/j.mrrev.2016.02.001
   Omar H.E.-D.M., 2016, AUSTIN J ENDOCRINOL, V3, P1042
   Pradas I, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-52263-w
   Pragasam SJ, 2013, INFLAMMATION, V36, P169, DOI 10.1007/s10753-012-9532-8
   Rena G, 2017, DIABETOLOGIA, V60, P1577, DOI 10.1007/s00125-017-4342-z
   Reuter SE, 2012, CLIN PHARMACOKINET, V51, P553, DOI 10.2165/11633940-000000000-00000
   Rivera ME, 2020, J CELL BIOCHEM, V121, P816, DOI 10.1002/jcb.29327
   Rotermund C, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00400
   Ryan PM, 2020, CAN J DIABETES, V44, P146, DOI 10.1016/j.jcjd.2019.05.008
   Sanchez-Rangel E, 2017, DIABETOLOGIA, V60, P1586, DOI 10.1007/s00125-017-4336-x
   Saravi SSS, 2016, PHARM BIOL, V54, P2830, DOI 10.1080/13880209.2016.1185633
   Seifarth C, 2013, EXP CLIN ENDOCR DIAB, V121, P27, DOI 10.1055/s-0032-1327734
   Siddik MA, 2019, ENDOCRINOL METAB, V34, P234, DOI 10.3803/EnM.2019.34.3.234
   Song RS, 2016, DIABETES CARE, V39, P187, DOI 10.2337/dci15-0013
   Tong XL, 2018, MBIO, V9, DOI 10.1128/mBio.02392-17
   Vinaixa M, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0029052
   Viollet B, 2012, CLIN SCI, V122, P253, DOI 10.1042/CS20110386
   Wang DZ, 2010, NAT REV CANCER, V10, P181, DOI 10.1038/nrc2809
   Wang Z, 2019, CELL BIOSCI, V9, DOI 10.1186/s13578-019-0332-9
   Worley B, 2013, CURR METABOL, V1, P92, DOI 10.2174/2213235X11301010092
   Zhao Y, 2018, GYNECOL ENDOCRINOL, V34, P428, DOI 10.1080/09513590.2017.1409714
   Zhernakova A, 2016, SCIENCE, V352, P565, DOI 10.1126/science.aad3369
   Zhu YY, 2013, J CHROMATOGR B, V925, P110, DOI 10.1016/j.jchromb.2013.02.040
NR 63
TC 12
Z9 12
U1 2
U2 10
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD JUL 15
PY 2021
VL 12
AR 705932
DI 10.3389/fphar.2021.705932
PG 12
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA TR6KQ
UT WOS:000679071900001
PM 34335266
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Alemon-Medina, R
   Coria-Jimenez, R
   Rivera-Espinosa, L
   Ramirez-Mendiola, B
   Garcia-Alvarez, R
   Juarez-Olguin, H
   Chavez-Pacheco, JL
AF Alemon-Medina, Radames
   Coria-Jimenez, Rafael
   Rivera-Espinosa, Liliana
   Ramirez-Mendiola, Blanca
   Garcia-Alvarez, Raquel
   Juarez-Olguin, Hugo
   Luis Chavez-Pacheco, Juan
TI Physicochemical and Microbiological Stabilities of a Sweetened and
   Calorie-Free Metformin Extemporaneous Formulation for Pediatrics
SO LATIN AMERICAN JOURNAL OF PHARMACY
LA English
DT Article
DE Extemporaneous formulation; Individualized dose; Insulin resistance;
   Metformin; Microbial stability; Physicochemical integrity
ID METABOLIC SYNDROME; CHILDREN
AB A liquid extemporaneous metformin formulation from Glucophage (R) tablets was prepared in drinking water sweetened with 10 % Splenda (R), then stored for 30 days at 25 degrees C exposed to and protected from light, at 4 and 40 degrees C. Physicochemical integrity was determined by UPLC-UV using a VARIAN Pursuit C8 column 150 x 3.9 mm at 40 degrees C, with detection at 236 nm. Mobile phase was 0.1M KH2PO4 (pH = 6.5) : 4.6 mM SDS : acetonitrile (63: 7: 30 v/v) eluted at 0.8 mL/min. Microbial colony forming units per milliliter (CFU/mL) were determined in soy agar trypticasein (SAT), McConkey agar, and Sabouraud media at 37 and 29 degrees C for 72 and 96 h. The solution retained over 90 % of the initial amount of metformin, showing zero-growth of enteric or aerobic mesophilic bacteria and was able to restore normal glucose levels in chronically hyperglycemic Wistar rats. This metformin formulation may be helpful managing insulin resistance in pediatric endocrinology.
C1 [Alemon-Medina, Radames; Rivera-Espinosa, Liliana; Ramirez-Mendiola, Blanca; Garcia-Alvarez, Raquel; Juarez-Olguin, Hugo; Luis Chavez-Pacheco, Juan] Minist Hlth, Natl Inst Pediat, Pharmacol Lab, Mexico City 04530, DF, Mexico.
   [Coria-Jimenez, Rafael] Minist Hlth, Natl Inst Pediat, Expt Bacteriol Lab, Mexico City 04530, DF, Mexico.
RP Chavez-Pacheco, JL (通讯作者)，Minist Hlth, Natl Inst Pediat, Pharmacol Lab, Mexico Insurgentes 3-700-C, Mexico City 04530, DF, Mexico.
EM jchavez_pacheco@hotmail.com
RI CHAVEZ PACHECO, JUAN LUIS/HJA-3400-2022
OI CHAVEZ PACHECO, JUAN LUIS/0000-0001-6919-4497; RIVERA ESPINOSA,
   LILIANA/0000-0002-1334-0026
CR Bailey CJ, 1996, NEW ENGL J MED, V334, P574, DOI 10.1056/NEJM199602293340906
   Chavez-Pacheco JL, 2011, LAT AM J PHARM, V30, P1977
   de Silva-Sanigorski A, 2010, BMC PUBLIC HEALTH, V10, DOI 10.1186/1471-2458-10-288
   de Leon-Castaneda C, 2012, CLINICOECONOMIC OUTC, V4, P57, DOI 10.2147/CEOR.S27826
   Fulgencio JP, 2001, BIOCHEM PHARMACOL, V62, P439, DOI 10.1016/S0006-2952(01)00679-7
   Garnett SP, 2010, BMC PUBLIC HEALTH, V10, DOI 10.1186/1471-2458-10-575
   HERMANN LS, 1994, DIABETES CARE, V17, P1100, DOI 10.2337/diacare.17.10.1100
   Juarez-Olguin H, 2011, ACTA PEDIATR MEX, V32, P175
   Kanekara A., 2010, J CLIN MED RES, V3, P105
   LALAU JD, 1995, DIABETES CARE, V18, P779, DOI 10.2337/diacare.18.6.779
   NORMA Oficial Mexicana, 2010, NOM008SSA32010
   Nunn AJ, 2003, ARCH DIS CHILD, V88, P369, DOI 10.1136/adc.88.5.369
   Perichart-Perera O, 2007, J AM DIET ASSOC, V107, P81, DOI 10.1016/j.jada.2006.10.011
   Schirm E, 2003, PEDIATRICS, V111, P291, DOI 10.1542/peds.111.2.291
   Standing JF, 2005, INT J PHARMACEUT, V300, P56, DOI 10.1016/j.ijpharm.2005.05.006
   Strickley RG, 2008, J PHARM SCI-US, V97, P1731, DOI 10.1002/jps.21101
   Ventura EE, 2008, J AM DIET ASSOC, V108, P1355, DOI 10.1016/j.jada.2008.05.006
   Wang Z., 2010, WEI SHENG YAN JIU, V2, P133
   YOUNG DA, 1990, J DENT RES, V69, P1480, DOI 10.1177/00220345900690080601
NR 19
TC 7
Z9 7
U1 0
U2 5
PU COLEGIO FARMACEUTICOS PROVINCIA DE BUENOS AIRES
PI LA PLATA
PA DEPT CIENTIFICO, CALLE 5 NO 966, LA PLATA, 00000, ARGENTINA
SN 0326-2383
J9 LAT AM J PHARM
JI Lat. Am. J. Pharm.
PY 2012
VL 31
IS 9
BP 1253
EP 1260
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA V31CG
UT WOS:000208861100004
DA 2023-06-08
ER

PT J
AU Takahara, M
   Takaki, A
   Hiraoka, S
   Takei, K
   Yasutomi, E
   Igawa, S
   Yamamoto, S
   Oka, S
   Ohmori, M
   Yamasaki, Y
   Inokuchi, T
   Kinugasa, H
   Harada, K
   Udono, H
   Okada, H
AF Takahara, Masahiro
   Takaki, Akinobu
   Hiraoka, Sakiko
   Takei, Kensuke
   Yasutomi, Eriko
   Igawa, Shoko
   Yamamoto, Shumpei
   Oka, Shohei
   Ohmori, Masayasu
   Yamasaki, Yasushi
   Inokuchi, Toshihiro
   Kinugasa, Hideaki
   Harada, Keita
   Udono, Heiichiro
   Okada, Hiroyuki
TI Metformin ameliorates chronic colitis in a mouse model by regulating
   interferon-gamma-producing lamina propria CD4(+) T cells through AMPK
   activation
SO FASEB JOURNAL
LA English
DT Article
DE AMP-activated protein kinase; chronic colitis; metformin; oxidative
   phosphorylation
ID INFLAMMATORY-BOWEL-DISEASE; GUT MICROBIOTA; SCID MICE; MECHANISMS;
   IL-17; RISK; DRUG
AB Metformin, a commonly prescribed drug for type 2 diabetes mellitus, has been shown to activate AMP-activated protein kinase (AMPK). Notably, AMPK activation has recently been observed to be associated with anti-inflammatory responses. Metformin is also reported to elicit anti-inflammatory responses in CD4(+) T cells, resulting in improvement in experimental chronic inflammatory diseases, such as systemic lupus erythematosus. To investigate the effect of metformin on inflammatory bowel disease (IBD), we developed a T cell-transfer model of chronic colitis in which SCID mice were injected with CD4(+)CD45RB(high) T cells to induce colitis. We examined the effects of metformin via in vitro and in vivo experiments on lamina propria (LP) CD4(+) T cells. We observed that metformin suppresses the frequency of interferon (IFN) -gamma-producing LP CD4(+) T cells in vitro, which were regulated by AMPK activation, a process possibly induced by the inhibition of oxidative phosphorylation. Furthermore, we examined the effects of metformin on an in vivo IBD model. Metformin-treated mice showed AMPK activation in LP CD4(+) T cells and ameliorated colitis. Our study demonstrates that metformin-induced AMPK activation in mucosal CD4(+) T cells contributes to the improvement of IBD by suppressing IFN-gamma production. Moreover, our results indicate that AMPK may be a target molecule for the regulation of mucosal immunity and inflammation. Thus, AMPK-activating drugs such as metformin may be potential therapeutic agents for the treatment of IBD.
C1 [Takahara, Masahiro; Takaki, Akinobu; Hiraoka, Sakiko; Takei, Kensuke; Yasutomi, Eriko; Igawa, Shoko; Yamamoto, Shumpei; Oka, Shohei; Ohmori, Masayasu; Yamasaki, Yasushi; Inokuchi, Toshihiro; Kinugasa, Hideaki; Harada, Keita; Okada, Hiroyuki] Okayama Univ, Dept Gastroenterol & Hepatol, Grad Sch Med Dent & Pharmaceut Sci, Okayama, Japan.
   [Udono, Heiichiro] Okayama Univ, Dept Immunol Dent & Pharmaceut Sci, Grad Sch Med, Okayama, Japan.
C3 Okayama University; Okayama University
RP Takahara, M (通讯作者)，Okayama Univ, Dept Gastroenterol & Lepatol, Grad Sch Med Dent & Pharmaceut Sci, Kita Ku, 2-5-1 Shikata Cho, Okayama 7008558, Japan.
EM mtakahara@cc.okayama-u.ac.jp
RI Yamasaki, Yasushi/H-8863-2019
OI Yamasaki, Yasushi/0000-0002-2992-9863; Takahara,
   Masahiro/0000-0002-4601-6644
FU MEXT | Japan Society for the Promotion of Science (JSPS) [JP20K16957]
FX MEXT | Japan Society for the Promotion of Science (JSPS), Grant/Award
   Number: JP20K16957
CR Abraham C, 2009, NEW ENGL J MED, V361, P2066, DOI 10.1056/NEJMra0804647
   Aljofan M, 2019, FUTUR SCI OA, V5, DOI 10.2144/fsoa-2019-0053
   Bian XY, 2019, FRONT MICROBIOL, V10, DOI 10.3389/fmicb.2019.02259
   Bregenholt S, 1998, CLIN EXP IMMUNOL, V111, P166
   Caporaso JG, 2010, NAT METHODS, V7, P335, DOI 10.1038/nmeth.f.303
   Chen L, 2018, FRONT PHARMACOL, V9, DOI 10.3389/fphar.2018.00761
   Costello SP, 2019, JAMA-J AM MED ASSOC, V321, P156, DOI 10.1001/jama.2018.20046
   Dao MC, 2016, GUT, V65, P426, DOI 10.1136/gutjnl-2014-308778
   Dulai PS, 2014, GASTROENTEROL CLIN N, V43, P525, DOI 10.1016/j.gtc.2014.05.010
   Eikawa S, 2015, P NATL ACAD SCI USA, V112, P1809, DOI 10.1073/pnas.1417636112
   Foretz M, 2014, CELL METAB, V20, P953, DOI 10.1016/j.cmet.2014.09.018
   Guo GL, 2018, NAT MED, V24, P1789, DOI 10.1038/s41591-018-0273-6
   Hardie DG, 2012, NAT REV MOL CELL BIO, V13, P251, DOI 10.1038/nrm3311
   Hawley SA, 2002, DIABETES, V51, P2420, DOI 10.2337/diabetes.51.8.2420
   Hosono K, 2010, CANCER PREV RES, V3, P1077, DOI 10.1158/1940-6207.CAPR-10-0186
   Kang KY, 2013, INT IMMUNOPHARMACOL, V16, P85, DOI 10.1016/j.intimp.2013.03.020
   Kaser A, 2010, ANNU REV IMMUNOL, V28, P573, DOI 10.1146/annurev-immunol-030409-101225
   Kim JW, 2019, ARTHRITIS RES THER, V21, DOI 10.1186/s13075-019-1904-0
   Koh SJ, 2014, J GASTROEN HEPATOL, V29, P502, DOI 10.1111/jgh.12435
   Kopylov U, 2015, INFLAMM BOWEL DIS, V21, P1847, DOI 10.1097/MIB.0000000000000457
   Lee SY, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0135858
   Li J, 2017, MICROBIOME, V5, DOI 10.1186/s40168-016-0222-x
   Lotfi N, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.01265
   Ma EH, 2017, CURR OPIN IMMUNOL, V46, P45, DOI 10.1016/j.coi.2017.04.004
   Murphy KM, 2002, NAT REV IMMUNOL, V2, P933, DOI 10.1038/nri954
   Nemoto Y, 2013, GUT, V62, P1142, DOI 10.1136/gutjnl-2012-302029
   Newton R, 2016, NAT IMMUNOL, V17, P618, DOI 10.1038/ni.3466
   Ni J, 2017, NAT REV GASTRO HEPAT, V14, P573, DOI 10.1038/nrgastro.2017.88
   O'Connor W, 2009, NAT IMMUNOL, V10, P603, DOI 10.1038/ni.1736
   O'Malley JT, 2008, J IMMUNOL, V181, P5062, DOI 10.4049/jimmunol.181.7.5062
   Ogawa A, 2004, CLIN IMMUNOL, V110, P55, DOI 10.1016/j.clim.2003.09.013
   Pollak M, 2017, DIABETOLOGIA, V60, P1662, DOI 10.1007/s00125-017-4352-x
   POWRIE F, 1994, IMMUNITY, V1, P553, DOI 10.1016/1074-7613(94)90045-0
   Rangarajan S, 2018, NAT MED, V24, P1121, DOI 10.1038/s41591-018-0087-6
   Rutgeerts P, 2005, NEW ENGL J MED, V353, P2462, DOI 10.1056/NEJMoa050516
   Sanchez B, 2017, MOL NUTR FOOD RES, V61, DOI 10.1002/mnfr.201600240
   Shamoon M, 2019, PHARMACOL RES, V148, DOI 10.1016/j.phrs.2019.104344
   Shiomi A, 2015, MEDIAT INFLAMM, V2015, DOI 10.1155/2015/568543
   Soto-Heredero G, 2020, FEBS J, V287, P3350, DOI 10.1111/febs.15327
   Takahara M, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-48331-w
   Takahashi S, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0105592
   Titov AA, 2019, J IMMUNOL, V203, P338, DOI 10.4049/jimmunol.1801651
   Totsuka T, 2008, EUR J IMMUNOL, V38, P1275, DOI 10.1002/eji.200737914
   Vial G, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00294
   Vila AV, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-019-14177-z
   Wang SX, 2011, HYPERTENSION, V57, P1010, DOI 10.1161/HYPERTENSIONAHA.110.168906
   Yen D, 2006, J CLIN INVEST, V116, P1310, DOI 10.1172/JCI21404
   Yin YM, 2016, J IMMUNOL, V196, P80, DOI 10.4049/jimmunol.1501537
   Zhai R, 2019, FRONT CELL INFECT MI, V9, DOI 10.3389/fcimb.2019.00239
   Zhang Z, 2006, INFLAMM BOWEL DIS, V12, P382, DOI 10.1097/01.MIB.0000218764.06959.91
   Zhang Z, 2017, NUTRIENTS, V9, DOI 10.3390/nu9070677
NR 51
TC 4
Z9 4
U1 1
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD FEB
PY 2022
VL 36
IS 2
AR e22139
DI 10.1096/fj.202100831RR
PG 14
WC Biochemistry & Molecular Biology; Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA YO5NJ
UT WOS:000747987800042
PM 35064693
DA 2023-06-08
ER

PT J
AU Napolitano, A
   Miller, S
   Nicholls, AW
   Baker, D
   Van Horn, S
   Thomas, E
   Rajpal, D
   Spivak, A
   Brown, JR
   Nunez, DJ
AF Napolitano, Antonella
   Miller, Sam
   Nicholls, Andrew W.
   Baker, David
   Van Horn, Stephanie
   Thomas, Elizabeth
   Rajpal, Deepak
   Spivak, Aaron
   Brown, James R.
   Nunez, Derek J.
TI Novel Gut-Based Pharmacology of Metformin in Patients with Type 2
   Diabetes Mellitus
SO PLOS ONE
LA English
DT Article
ID GLUCAGON-LIKE PEPTIDE-1; BILE-ACID; ORAL METFORMIN; IV ACTIVITY;
   MICROBIOTA; GLUCOSE; METABOLISM; OBESITY; DEGRADATION; INHIBITION
AB Metformin, a biguanide derivate, has pleiotropic effects beyond glucose reduction, including improvement of lipid profiles and lowering microvascular and macrovascular complications associated with type 2 diabetes mellitus (T2DM). These effects have been ascribed to adenosine monophosphate-activated protein kinase (AMPK) activation in the liver and skeletal muscle. However, metformin effects are not attenuated when AMPK is knocked out and intravenous metformin is less effective than oral medication, raising the possibility of important gut pharmacology. We hypothesized that the pharmacology of metformin includes alteration of bile acid recirculation and gut microbiota resulting in enhanced enteroendocrine hormone secretion. In this study we evaluated T2DM subjects on and off metformin monotherapy to characterize the gut-based mechanisms of metformin. Subjects were studied at 4 time points: (i) at baseline on metformin, (ii) 7 days after stopping metformin, (iii) when fasting blood glucose (FBG) had risen by 25% after stopping metformin, and (iv) when FBG returned to baseline levels after restarting the metformin. At these timepoints we profiled glucose, insulin, gut hormones (glucagon-like peptide-1 (GLP-1), peptide tyrosine-tyrosine (PYY) and glucose-dependent insulinotropic peptide (GIP) and bile acids in blood, as well as duodenal and faecal bile acids and gut microbiota. We found that metformin withdrawal was associated with a reduction of active and total GLP-1 and elevation of serum bile acids, especially cholic acid and its conjugates. These effects reversed when metformin was restarted. Effects on circulating PYY were more modest, while GIP changes were negligible. Microbiota abundance of the phylum Firmicutes was positively correlated with changes in cholic acid and conjugates, while Bacteroidetes abundance was negatively correlated. Firmicutes and Bacteroidetes representation were also correlated with levels of serum PYY. Our study suggests that metformin has complex effects due to gut-based pharmacology which might provide insights into novel therapeutic approaches to treat T2DM and associated metabolic diseases.
C1 [Napolitano, Antonella] GlaxoSmithKline Res & Dev Ltd, Immunoinflammat Unit, Stevenage, Herts, England.
   [Miller, Sam] GlaxoSmithKline Res & Dev Ltd, Quantitat Sci, Stevenage, Herts, England.
   [Nicholls, Andrew W.; Baker, David] GlaxoSmithKline Res & Dev Ltd, Safety Assessment, Ware, Herts, England.
   [Van Horn, Stephanie; Thomas, Elizabeth] GlaxoSmithKline Res & Dev Ltd, Target & Pathways Validat, Upper Providence, PA USA.
   [Rajpal, Deepak; Spivak, Aaron; Brown, James R.] GlaxoSmithKline Res & Dev Ltd, Computat Biol, Upper Providence, PA USA.
   [Nunez, Derek J.] GlaxoSmithKline Res & Dev Ltd, GlaxoSmithKline R&D, Enteroendocrine Discovery Unit, Res Triangle Pk, NC USA.
C3 GlaxoSmithKline; GlaxoSmithKline; GlaxoSmithKline; GlaxoSmithKline;
   GlaxoSmithKline; GlaxoSmithKline
RP Napolitano, A (通讯作者)，GlaxoSmithKline Res & Dev Ltd, Immunoinflammat Unit, Stevenage, Herts, England.
EM antonella.2.napolitano@gsk.com
OI Brown, James/0000-0002-9368-627X
FU GlaxoSmithKline
FX The study has been fully funded by GlaxoSmithKline. The funder provided
   support in the form of salaries for authors [AN, SM, AWN, DB, SVH, ET,
   DR, AS, JRB and DJN], but did not have any additional role in the study
   design, data collection and analysis, decision to publish, or
   preparation of the manuscript. The specific roles of these authors are
   articulated in the 'author contributions' section.
CR [Anonymous], 1996, ICH HARM TRIP GUID G
   Backhed F, 2004, P NATL ACAD SCI USA, V101, P15718, DOI 10.1073/pnas.0407076101
   BENJAMINI Y, 1995, J R STAT SOC B, V57, P289, DOI 10.1111/j.2517-6161.1995.tb02031.x
   BONORA E, 1984, CURR MED RES OPIN, V9, P47, DOI 10.1185/03007998409109558
   Cabreiro F, 2013, CELL, V153, P228, DOI 10.1016/j.cell.2013.02.035
   Cani PD, 2012, GUT MICROBES, V3, P279, DOI 10.4161/gmic.19625
   Cani PD, 2011, PHARMACOL THERAPEUT, V130, P202, DOI 10.1016/j.pharmthera.2011.01.012
   Caporaso JG, 2010, NAT METHODS, V7, P335, DOI 10.1038/nmeth.f.303
   Carter D, 2003, DIABETES OBES METAB, V5, P120, DOI 10.1046/j.1463-1326.2003.00252.x
   Chen XS, 2011, EXP DIABETES RES, DOI 10.1155/2011/853501
   Cho KW, 2010, J NUTR BIOCHEM, V21, P841, DOI 10.1016/j.jnutbio.2009.06.012
   Cuthbertson J, 2009, DIABETIC MED, V26, P649, DOI 10.1111/j.1464-5491.2009.02748.x
   Deacon CF, 2004, HORM METAB RES, V36, P761, DOI 10.1055/s-2004-826160
   DeSantis TZ, 2006, APPL ENVIRON MICROB, V72, P5069, DOI 10.1128/AEM.03006-05
   Drucker DJ, 2006, CELL METAB, V3, P153, DOI 10.1016/j.cmet.2006.01.004
   Edgar RC, 2010, BIOINFORMATICS, V26, P2460, DOI 10.1093/bioinformatics/btq461
   Galman C, 2005, GASTROENTEROLOGY, V129, P1445, DOI 10.1053/j.gastro.2005.09.009
   GIUGLIANO D, 1993, DIABETES CARE, V16, P1387, DOI 10.2337/diacare.16.10.1387
   Green BD, 2006, EUR J PHARMACOL, V547, P192, DOI 10.1016/j.ejphar.2006.07.043
   Greenway F, 2013, BENEF MICROBES, V17, P1
   Gui J, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0064585
   Guiney WJ, 2010, DRUG METAB DISPOS, V38, P851, DOI 10.1124/dmd.109.031062
   Haas BJ, 2011, GENOME RES, V21, P494, DOI 10.1101/gr.112730.110
   Hinke SA, 2002, BIOCHEM BIOPH RES CO, V291, P1302, DOI 10.1006/bbrc.2002.6607
   Holst JJ, 2007, PHYSIOL REV, V87, P1409, DOI 10.1152/physrev.00034.2006
   Islam KBMS, 2011, GASTROENTEROLOGY, V141, P1773, DOI 10.1053/j.gastro.2011.07.046
   Karlsson F, 2013, DIABETES, V62, P3341, DOI 10.2337/db13-0844
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   le Roux CW, 2006, ENDOCRINOLOGY, V147, P3, DOI 10.1210/en.2005-0972
   Legro RS, 2013, J CLIN ENDOCRINOL ME
   Ley RE, 2006, NATURE, V444, P1022, DOI 10.1038/4441022a
   Lindsay JR, 2005, DIABETIC MED, V22, P654, DOI 10.1111/j.1464-5491.2005.01461.x
   Lozupone C, 2011, ISME J, V5, P169, DOI 10.1038/ismej.2010.133
   Maruo T, 2008, INT J SYST EVOL MICR, V58, P1221, DOI 10.1099/ijs.0.65404-0
   Maurice CF, 2013, CELL, V152, P39, DOI 10.1016/j.cell.2012.10.052
   Migoya EM, 2010, CLIN PHARMACOL THER, V88, P801, DOI 10.1038/clpt.2010.184
   Miller RA, 2013, NATURE, V494, P256, DOI 10.1038/nature11808
   Mulherin AJ, 2011, ENDOCRINOLOGY, V152, P4610, DOI 10.1210/en.2011-1485
   Navas-Molina JA, 2013, METHOD ENZYMOL, V531, P371, DOI 10.1016/B978-0-12-407863-5.00019-8
   Proctor WR, 2008, DRUG METAB DISPOS, V36, P1650, DOI 10.1124/dmd.107.020180
   Quinn BJ, 2013, TRENDS ENDOCRINOL ME, V24
   Rena G, 2013, DIABETOLOGIA, V56, P1898, DOI 10.1007/s00125-013-2991-0
   Schwen RJ, 2012, FOOD CHEM TOXICOL, V50, P2074, DOI 10.1016/j.fct.2012.03.048
   Shields William W, 2009, Therap Adv Gastroenterol, V2, P157, DOI 10.1177/1756283X09105462
   Standard of Medical Care in Diabetes -American Diabetes Association, 2013, DIABETES CARE S1, V36
   Stepensky D, 2002, DRUG METAB DISPOS, V30, P861, DOI 10.1124/dmd.30.8.861
   Tharakan G, 2011, TRENDS PHARMACOL SCI, V32, P8, DOI 10.1016/j.tips.2010.10.003
   Thomas C, 2009, CELL METAB, V10, P167, DOI 10.1016/j.cmet.2009.08.001
   Thondam SK, 2012, DIABETIC MED, V29, pE205, DOI 10.1111/j.1464-5491.2012.03675.x
   Toh H, 2013, GENOME ANNOUNC, V24
   Tremaroli V, 2012, NATURE, V489, P242, DOI 10.1038/nature11552
   Turnbaugh PJ, 2008, CELL HOST MICROBE, V3, P213, DOI 10.1016/j.chom.2008.02.015
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Vardarli I, 2014, DIABETES, V63, P663, DOI 10.2337/db13-0805
   Zhou GC, 2001, J CLIN INVEST, V108, P1167, DOI 10.1172/JCI200113505
NR 55
TC 186
Z9 191
U1 0
U2 36
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUL 2
PY 2014
VL 9
IS 7
AR e100778
DI 10.1371/journal.pone.0100778
PG 14
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA AO5BA
UT WOS:000341354100043
PM 24988476
OA gold, Green Published, Green Submitted
DA 2023-06-08
ER

PT J
AU Pastor-Villaescusa, B
   Caballero-Villarraso, J
   Canete, MD
   Hoyos, R
   Maldonado, J
   Bueno, G
   Leis, R
   Gil, A
   Canete, R
   Aguilera, CM
AF Pastor-Villaescusa, Belen
   Caballero-Villarraso, Javier
   Dolores Canete, M.
   Hoyos, Raul
   Maldonado, Jose
   Bueno, Gloria
   Leis, Rosaura
   Gil, Angel
   Canete, Ramon
   Aguilera, Concepcion M.
TI Evaluation of differential effects of metformin treatment in obese
   children according to pubertal stage and genetic variations: study
   protocol for a randomized controlled trial
SO TRIALS
LA English
DT Article
DE Metformin; Children; Obesity; Puberty; Lifestyle intervention;
   Microbiota; Polymorphisms
ID NORMAL GLUCOSE-TOLERANCE; LIFE-STYLE; INSULIN-RESISTANCE;
   PHYSICAL-ACTIVITY; FASTING INSULIN; CLINICAL-TRIAL; DOUBLE-BLIND;
   ADOLESCENTS; WEIGHT; TRANSPORTER
AB Background: Overweight and obesity are considered to be serious public health problems. In pediatric populations, insulin resistance, dyslipidemia, and hypertension associated with obesity occur with increased frequencies. Metformin is an oral anti-hyperglycemic agent that has been demonstrated to be efficacious in the treatment of diabetic and non-diabetic obese adults. A considerable amount of pharmacogenetic research has demonstrated that genetic variation is one of the major factors affecting metformin response. Additionally, potential microbiota-mediated mechanisms of metformin effect have been recently described. However, scant work has been conducted in children, with no attention being paid to the potential effects of pubertal development. Thus, the main objective of the present study is to evaluate the effect of metformin treatment together with lifestyle recommendations in a randomized control trial (RCT) of obese children according to pubertal stage, genetic variants and signature of gut microbiota.
   Methods/design: This is a randomized, prospective, double-blind, placebo-controlled, multicenter trial, which is stratified by puberty and sex. Eighty pre-pubertal (40 boys and 40 girls) and 80 pubertal non-diabetic obese children (40 boys and 40 girls) are being recruited in four Spanish Clinical Hospitals. The inclusion criteria to participate in the RCT include a Body Mass Index (BMI) above the 95th percentile and age 7-14 years. The pubertal stage is determined based on the Tanner criteria. Participants are assigned to two groups in accordance with a randomization schedule and receive 1 g of metformin or placebo for six months in combination with healthy lifestyle recommendations in both groups. The primary outcomes include changes in the BMI Z score and the biomarkers associated with the early appearance of insulin resistance syndrome, inflammation, cardiovascular risk according of the presence of genetic determinants of metformin response, as well as possible modifications in microbiota.
   Discussion: This study will assess the differential response of metformin treatment at six months in pre-pubertal and pubertal obese children.
C1 [Pastor-Villaescusa, Belen; Gil, Angel; Aguilera, Concepcion M.] Univ Granada, Ctr Biomed Res Lab 123, Inst Nutr & Food Technol, Dept Biochem & Mol Biol 2, Ave Conocimiento S-N, Granada 18006, Spain.
   [Caballero-Villarraso, Javier] Univ Cordoba, IMIBIC Reina Sofia Hosp, Clin Anal Serv, Cordoba, Spain.
   [Dolores Canete, M.] Maimonides Inst Biomed Res Cordoba IMIBIC, PAIDI CTS 329, Cordoba, Spain.
   [Hoyos, Raul] Virgen de las Univ Hosp, Andalusian Hlth Serv, Dept Pediat, Granada, Spain.
   [Maldonado, Jose] Univ Granada, Dept Pediat, Virgen de las Nieves Univ Hosp, Pediat Gastroenterol & Nutr Unit, Granada, Spain.
   [Bueno, Gloria] Univ Zaragoza, Lozano Blesa Univ Clin Hosp, Dept Pediat, Zaragoza, Spain.
   [Leis, Rosaura] Univ Santiago de Compostela, Clin Univ Hosp Santiago, Dept Pediat, Unit Invest Nutr Growth & Human Dev Galicia, Santiago De Compostela, Spain.
   [Canete, Ramon] Reina Sofia Univ Hosp, Unit Pediat Endocrinol, Cordoba, Spain.
   [Bueno, Gloria; Leis, Rosaura; Gil, Angel; Canete, Ramon; Aguilera, Concepcion M.] CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid, Spain.
   [Gil, Angel; Aguilera, Concepcion M.] Inst Invest Biosanitaria Ibs, Granada, Spain.
C3 University of Granada; Universidad de Cordoba; Hospital Universitario
   Virgen de las Nieves; University of Granada; Lozano Blesa University
   Clinical Hospital; University of Zaragoza; Complexo Hospitalario
   Universitario de Santiago de Compostela; Universidade de Santiago de
   Compostela; Hospital Universitario Reina Sofia - Cordoba; CIBER - Centro
   de Investigacion Biomedica en Red; CIBEROBN; Instituto de Investigacion
   Biosanitaria IBS Granada
RP Aguilera, CM (通讯作者)，Univ Granada, Ctr Biomed Res Lab 123, Inst Nutr & Food Technol, Dept Biochem & Mol Biol 2, Ave Conocimiento S-N, Granada 18006, Spain.; Aguilera, CM (通讯作者)，CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid, Spain.; Aguilera, CM (通讯作者)，Inst Invest Biosanitaria Ibs, Granada, Spain.
EM caguiler@ugr.es
RI Bueno-Lozano, Gloria/AAK-7748-2021; Leis, Rosaura/Z-3186-2019; Pastor
   Villaescusa, Maria Belen/U-2325-2017; Villaescusa, Maria Belen
   Pastor/ABA-2162-2021; Gil, Angel/L-2275-2014; Gil, Angel/ABA-7621-2020;
   Caballero-Villarraso, Javier/AAC-3434-2019; Pastor-Villaescusa,
   Belén/GRF-0832-2022; Aguilera, Concepcion M/M-1663-2014
OI Leis, Rosaura/0000-0002-0540-4210; Pastor Villaescusa, Maria
   Belen/0000-0003-0817-6804; Villaescusa, Maria Belen
   Pastor/0000-0003-0817-6804; Gil, Angel/0000-0001-7663-0939; Gil,
   Angel/0000-0001-7663-0939; Caballero-Villarraso,
   Javier/0000-0003-0571-5147; Aguilera, Concepcion M/0000-0002-1451-4788
FU Spanish Ministry of Health, Social and Equality, General Department for
   Pharmacy and Health Products; PN I + D + I (Spain);
   ISCIII-Sub-Directorate General for Research Assessment and Promotion;
   European Regional Development Fund (ERDF) [Rd12/0026]
FX We would like to acknowledge the Spanish Ministry of Health, Social and
   Equality, General Department for Pharmacy and Health Products for
   financing this study; RETICS funded by the PN I + D + I 2008-2011
   (Spain), ISCIII-Sub-Directorate General for Research Assessment and
   Promotion and The European Regional Development Fund (ERDF), Ref.
   Rd12/0026. Furthermore, the members of the project group who participate
   in the data and sample collection and the development of the FFQ (Miriam
   Latorre, PhD student, Pediatric Department, Lozano Blesa University
   Hospital, University of Zaragoza. Zaragoza, Spain; Rocio Vazquez-Cobela,
   PhD student, Unit of Investigation in Nutrition, Growth and Human
   Development of Galicia, Pediatric Department, Clinic University Hospital
   of Santiago, University of Santiago de Compostela. Santiago de
   Compostela, Spain). This paper will be part of Maria Belen Pastor
   Villaescusa's doctorate, which is being performed within the "Nutrition
   and Food Sciences Program" at the University of Granada.
CR Atabek ME, 2008, J PEDIATR ENDOCR MET, V21, P339
   Becker ML, 2009, PHARMACOGENOMICS J, V9, P242, DOI 10.1038/tpj.2009.15
   Becker MSL, 2009, DIABETES, V58, P745, DOI 10.2337/db08-1028
   Becker ML, 2010, PHARMACOGENET GENOM, V20, P38, DOI 10.1097/FPC.0b013e328333bb11
   Burgert TS, 2008, PEDIATR DIABETES, V9, P567, DOI 10.1111/j.1399-5448.2008.00434.x
   Canete R, 2007, EUR J NUTR, V46, P181, DOI 10.1007/s00394-007-0648-9
   Centers for Disease Control and Prevention (CDC), 2011, MMWR Morb Mortal Wkly Rep, V60, P37
   Chen SN, 2013, CURR DRUG METAB, V14, P1070, DOI 10.2174/1389200214666131211153933
   Cole TJ, 2000, BMJ-BRIT MED J, V320, P1240, DOI 10.1136/bmj.320.7244.1240
   Craig CL, 2003, MED SCI SPORT EXER, V35, P1381, DOI 10.1249/01.MSS.0000078924.61453.FB
   Evia-Viscarra ML, 2012, J PEDIAT ENDOCRINOL, P41
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Freedman DS, 1999, PEDIATRICS, V103, P1175, DOI 10.1542/peds.103.6.1175
   Freemark M, 2001, PEDIATRICS, V107, DOI 10.1542/peds.107.4.e55
   Golay A, 2008, INT J OBESITY, V32, P61, DOI 10.1038/sj.ijo.0803695
   Gomez-Diaz RA, 2012, METABOLISM, V61, P1247, DOI 10.1016/j.metabol.2012.02.003
   Kay JP, 2001, METABOLISM, V50, P1457, DOI 10.1053/meta.2001.28078
   Kendall D, 2013, J CLIN ENDOCR METAB, V98, P322, DOI 10.1210/jc.2012-2710
   Love-Osborne K, 2008, J PEDIATR, V152, P817, DOI 10.1016/j.jpeds.2008.01.018
   Maruthur NM, 2014, DIABETES CARE, V37, P876, DOI 10.2337/dc13-1276
   Mauras N, 2012, J PEDIATR ENDOCR MET, V25, P33, DOI 10.1515/jpem-2011-0450
   McDonagh MS, 2014, JAMA PEDIATR, V168, P178, DOI 10.1001/jamapediatrics.2013.4200
   Moreno LA, 2008, PUBLIC HEALTH NUTR, V11, P288, DOI 10.1017/S1368980007000535
   Reilly JJ, 2003, ARCH DIS CHILD, V88, P748, DOI 10.1136/adc.88.9.748
   Rogovik AL, 2010, DRUGS, V70, P335, DOI 10.2165/11319210-000000000-00000
   ROLLANDCACHERA MF, 1982, AM J CLIN NUTR, V36, P178, DOI 10.1093/ajcn/36.1.178
   Rynders C, 2012, MED SCI SPORT EXER, V44, P786, DOI 10.1249/MSS.0b013e31823cef5e
   Sanz Y, 2015, PEDIATR RES, V77, P236, DOI 10.1038/pr.2014.170
   Sobradillo B., 2004, CURVAS TABLAS CRECIM
   Srinivasan S, 2006, J CLIN ENDOCR METAB, V91, P2074, DOI 10.1210/jc.2006-0241
   TANNER JM, 1976, ARCH DIS CHILD, V51, P170, DOI 10.1136/adc.51.3.170
   Vyncke K, 2012, BR J NUTR, V25, P1
   Weiss R, 2004, NEW ENGL J MED, V350, P2362, DOI 10.1056/NEJMoa031049
   Wiegand S, 2010, EUR J ENDOCRINOL, V163, P585, DOI 10.1530/EJE-10-0570
   Wilson DM, 2010, ARCH PEDIAT ADOL MED, V164, P116, DOI 10.1001/archpediatrics.2009.264
   Yanovski JA, 2011, DIABETES, V60, P477, DOI 10.2337/db10-1185
NR 36
TC 6
Z9 7
U1 0
U2 11
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1745-6215
J9 TRIALS
JI Trials
PD JUL 18
PY 2016
VL 17
AR 323
DI 10.1186/s13063-016-1403-4
PG 10
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA DR3QB
UT WOS:000379816600002
PM 27432166
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Zhu, Y
   Li, Y
   Liu, M
   Hu, XD
   Zhu, HQ
AF Zhu, Ying
   Li, Yin
   Liu, Min
   Hu, XiaoDan
   Zhu, Hongqiu
TI Guizhi Fuling Wan, Chinese Herbal Medicine, Ameliorates Insulin
   Sensitivity in PCOS Model Rats With Insulin Resistance via Remodeling
   Intestinal Homeostasis
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE polycystic ovary syndrome; Guizhi Fuling Wan; gastrointestinal
   microbiome; insulin resistance; homeostasis
ID POLYCYSTIC-OVARY-SYNDROME; GUT MICROBIOTA; METABOLIC SYNDROME;
   DYSBIOSIS; WOMEN; INFLAMMATION
AB Polycystic ovary syndrome (PCOS) is a common endocrine disease with reproductive dysfunction and metabolic disorder in women of childbearing age. Gastrointestinal microbiome contributes to PCOS through mediating insulin resistance. Guizhi Fuling Wan, Chinese herbal medicine, can treat PCOS with insulin resistance (PCOS-IR), but the underlying mechanism is not clear. The aim of this study was to characterize the exact mechanism of Guizhi Fuling Wan action and whether it is related to the regulation of intestinal flora structure. We induced PCOS-IR rat model by means of letrozole sodium carboxymethyl cellulose (CMC-na) solution combined with high-fat emulsion administration and randomly divided it into blank control group (K), model control group (M), low dose of Guizhi Fuling Wan group (D), middle dose of Guizhi Fuling Wan group (Z), high dose of Guizhi Fuling Wan group (G) and positive drug (Metformin) control group (Y). After 36 days of modeling and treatment, serum and stool samples from all rats were collected for a follow-up analysis. The data display that, compared with K group, elevated testosterone and HOMA-IR, turbulent estrous cycles and polycystic ovaries in M group, indicating the PCOS-IR rat model is successfully established. Increased fasting insulin is associated with higher inflammation(plasma TNF-alpha, IL-6, and HS-CPR concentration were determined) in M group, and the altered intestinal flora (compared with the K group, in M group the relative abundance ofAlloprevotellawas decreased significantly, while the relative abundance ofLachnospiraceae UCG-008, Lachnospiraceae NK4A136, Lactobacillus, Ruminiclostridium 9, andRuminococcaceae UCG-003was increased significantly) induced the secretion of inflammatory markers. On the other hand, Guizhi Fuling Wan can alleviate inflammation, improve insulin resistence: Lower inflammation decreased fasting insulin can be seen in G group compared with M group, this effect is related to the regulating effect of Guizhi Fuling Wan on intestinal flora (in G group, the relative abundance ofAlloprevotella, Ruminococcaceae UCG-003, andLachnospiraceae UCG-008was increased significantly, compared with M group). This research demonstrates Guizhi Fuling Wan improve insulin resistance in polycystic ovary syndrome with the underlying mechanism of regulating intestinal flora to control inflammation. It would be useful to promote the therapeutic effect of Guizhi Fuling Wan on PCOS-IR.
C1 [Zhu, Ying; Li, Yin; Liu, Min; Hu, XiaoDan] Chengdu Univ Tradit Chinese Med, Sch Clin Med, Chengdu, Peoples R China.
   [Zhu, Hongqiu] Chengdu Univ Tradit Chinese Med, Coll Med & Life Sci, Chengdu, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine; Chengdu University
   of Traditional Chinese Medicine
RP Zhu, HQ (通讯作者)，Chengdu Univ Tradit Chinese Med, Coll Med & Life Sci, Chengdu, Peoples R China.
EM zhuhongqiu@cdutcm.edu.cn
OI liu, min/0000-0003-4535-0293
FU National Natural Science Foundation of China [81873335]; Department of
   Science and Technology of Chengdu province [2020YJ0376]; Second Clinical
   Medical College of Chengdu University of Traditional Chinese Medicine
   [2017-EL-14]
FX This work was supported by National Natural Science Foundation of China
   (81873335), Department of Science and Technology of Chengdu province
   (2020YJ0376), The Second Clinical Medical College of Chengdu University
   of Traditional Chinese Medicine(2017-EL-14).
CR Azziz R, 2018, OBSTET GYNECOL, V132, P321, DOI 10.1097/AOG.0000000000002698
   Backhed F, 2004, P NATL ACAD SCI USA, V101, P15718, DOI 10.1073/pnas.0407076101
   Cakiroglu Y, 2016, J ENDOCRINOL INVEST, V39, P899, DOI 10.1007/s40618-016-0446-4
   Caporaso JG, 2011, P NATL ACAD SCI USA, V108, P4516, DOI 10.1073/pnas.1000080107
   de Groot PF, 2017, GUT MICROBES, V8, P253, DOI 10.1080/19490976.2017.1293224
   Diamanti-Kandarakis E, 2012, ENDOCR REV, V33, P981, DOI 10.1210/er.2011-1034
   Dumesic DA, 2015, ENDOCR REV, V36, P487, DOI 10.1210/er.2015-1018
   Escobar-Morreale HF, 2018, NAT REV ENDOCRINOL, V14, P270, DOI 10.1038/nrendo.2018.24
   Escobar-Morreale HF, 2011, FERTIL STERIL, V95, P1048, DOI 10.1016/j.fertnstert.2010.11.036
   Fields EL, 2016, JAMA PEDIATR, V170, P502, DOI 10.1001/jamapediatrics.2015.4866
   Gonzalez F, 2012, J CLIN ENDOCR METAB, V97, P4071, DOI 10.1210/jc.2012-2131
   Insenser M, 2018, J CLIN ENDOCR METAB, V103, P2552, DOI 10.1210/jc.2017-02799
   Kafali H, 2004, ARCH MED RES, V35, P103, DOI 10.1016/j.arcmed.2003.10.005
   Kelley ST, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0146509
   Kelly CCJ, 2001, J CLIN ENDOCR METAB, V86, P2453, DOI 10.1210/jc.86.6.2453
   Khan MT, 2014, CELL METAB, V20, P753, DOI 10.1016/j.cmet.2014.07.006
   Kootte RS, 2017, CELL METAB, V26, P611, DOI 10.1016/j.cmet.2017.09.008
   Li R, 2013, HUM REPROD, V28, P2562, DOI 10.1093/humrep/det262
   Li YC, 2018, NUTRIENTS, V10, DOI 10.3390/nu10081024
   Lindheim L, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0168390
   Liu C, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-17736-w
   Liu J, 2018, PHARMACOL RES, V134, P40, DOI 10.1016/j.phrs.2018.05.012
   Liu R, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.00324
   Lixin Z, 2018, SHAANXI ZHONGYI, V39, P602, DOI [10.3969/j.issn.1000-7369.2018.05.018, DOI 10.3969/J.ISSN.1000-7369.2018.05.018]
   Ma ZH, 2017, BIOMED PHARMACOTHER, V90, P361, DOI 10.1016/j.biopha.2017.03.087
   Meng WB, 2019, MEDICINE, V98, DOI 10.1097/MD.0000000000016878
   Moreno-Indias I, 2016, ENDOCRINOLOGY, V157, P4888, DOI 10.1210/en.2016-1317
   Mykhalchenko K, 2017, EXPERT REV MOL DIAGN, V17, P723, DOI 10.1080/14737159.2017.1340833
   Norman RJ, 2007, LANCET, V370, P685, DOI 10.1016/S0140-6736(07)61345-2
   Ong M, 2017, AM J CHINESE MED, V45, P405, DOI 10.1142/S0192415X17500252
   Qi XY, 2019, NAT MED, V25, P1225, DOI 10.1038/s41591-019-0509-0
   Qiusheng Z, 2012, J NEW CHIN MED, V44, P116
   Quaranta G, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.02653
   Richards JL, 2016, CLIN TRANSL IMMUNOL, V5, DOI 10.1038/cti.2016.29
   Sinha SR, 2020, CELL HOST MICROBE, V27, P659, DOI 10.1016/j.chom.2020.01.021
   Stepto NK, 2019, J CLIN ENDOCR METAB, V104, P5369, DOI 10.1210/jc.2019-00167
   Torres PJ, 2019, ENDOCRINOLOGY, V160, P1193, DOI 10.1210/en.2019-00050
   Truax AD, 2018, CELL HOST MICROBE, V24, P364, DOI 10.1016/j.chom.2018.08.009
   [王尹瑜 Wang Yinyu], 2018, [上海交通大学学报. 医学版, Journal of Shanghai Jiaotong University .Medical Science], V38, P454
   Wen L, 2017, J NUTR, V147, p1468S, DOI 10.3945/jn.116.240754
   Xiaojuan X, 2016, J CHENGDU U TCM, V39, P5, DOI [10.13593/j.cnki.51-1501/r.2016.02.005, DOI 10.13593/J.CNKI.51-1501/R.2016.02.005]
   Yanjie G, 2016, PLOS ONE, V11, pe0153196, DOI 10.1371/journal.pone.0153196
   Yue W, 2006, SHANDONG MED J, V46, P70, DOI [10.3969/j.issn.1002-266X.2006.01.054, DOI 10.3969/J.ISSN.1002-266X.2006.01.054]
   Zhang Li-Shuang, 2017, Zhongguo Zhong Yao Za Zhi, V42, P1500, DOI 10.19540/j.cnki.cjcmm.2017.0048
   Zhou KY, 2016, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD007535.pub3
NR 45
TC 23
Z9 25
U1 3
U2 28
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD AUG 27
PY 2020
VL 11
AR 575
DI 10.3389/fendo.2020.00575
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA NP8NN
UT WOS:000570428300001
PM 32973686
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Shin, NR
   Bose, S
   Wang, JH
   Ansari, A
   Lim, SK
   Chin, YW
   Choi, HS
   Kim, H
AF Shin, Na R.
   Bose, Shambhunath
   Wang, Jing-Hua
   Ansari, AbuZar
   Lim, Soo-Kyoung
   Chin, Young-won
   Choi, Han-seok
   Kim, Hojun
TI Flos Lonicera Combined with Metformin Ameliorates Hepatosteatosis and
   Glucose Intolerance in Association with Gut Microbiota Modulation
SO FRONTIERS IN MICROBIOLOGY
LA English
DT Article
DE Flos Lonicera; metformin; metabolic syndrome; gut microbiota;
   hepatosteatosis
ID ACTIVATED PROTEIN-KINASE; FATTY LIVER-DISEASE; NONALCOHOLIC
   STEATOHEPATITIS; COMBINATION THERAPY; OXIDATIVE STRESS; JAPONICA THUNB.;
   ETHANOL EXTRACT; OBESITY; CHOLESTEROL; DIET
AB The gut microbiota is important in energy contribution, metabolism and immune modulation, and compositional disruption of the gut microbiota population is closely associated with chronic metabolic diseases like type 2 diabetes (T2D) and non-alcoholic fatty liver disease (NAFLD). Metformin (MET) and Flos Lonicera (FL) are common treatments for metabolic diseases inWestern and Oriental medicinal fields. We evaluated the effect of treatment with FL and MET in combination on hepatosteatosis, glucose tolerance, and gut microbial composition. FL and MET were administered to Otsuka Long-Evans Tokushima Fatty (OLETF) rats, an animal model of genetic T2D and NAFLD. The FL+MET treatment reduced liver weight, serum cholesterol, insulin resistance, and hepatic MDA level and modulated the gut microbial composition. More specifically, the genera of Prevotella and Lactobacillus were negatively associated with the body and liver weights, hepatic TG and TC content, and serum insulin level. However, the relative abundance of these genera decreased in response to the FL+ MET treatment. Interestingly, pathway prediction data revealed that the FL+ MET treatment attenuated lipopolysaccharide-related pathways, in keeping with the decrease in serum and fecal endotoxin levels. FL and MET in combination exerts a synergistic effect on the improvement of hepatosteatosis and insulin sensitivity in OLETF rats, and modulates gut microbiota in association with the effect.
C1 [Shin, Na R.; Wang, Jing-Hua; Ansari, AbuZar; Lim, Soo-Kyoung; Kim, Hojun] Dongguk Univ, Dept Rehabil Med Korean Med, Goyang, South Korea.
   [Bose, Shambhunath] NosQuest, Seongnam Si, Gyeonggi Do, South Korea.
   [Chin, Young-won] Dongguk Univ, Coll Pharm, Goyang, South Korea.
   [Choi, Han-seok] Dongguk Univ, Dept Endocrinol, Goyang, South Korea.
C3 Dongguk University; Dongguk University; Dongguk University
RP Kim, H (通讯作者)，Dongguk Univ, Dept Rehabil Med Korean Med, Goyang, South Korea.
EM kimklar@gmail.com
RI Bose, Shambhunath/HKW-2568-2023; Kim, Hojun/AAB-8405-2020; Choi, Han
   Seok/AAG-1493-2019; Wang, Jing-hua/AAO-2350-2020; ANSARI,
   ABUZAR/AAZ-2578-2020
OI Wang, Jing-hua/0000-0002-2034-7429; Bose,
   Shambunath/0000-0003-0737-5713; Chin, Young-Won/0000-0001-6964-1779
FU Convergence of Conventional Medicine and Traditional Korean Medicine R&D
   program - Ministry of Health and Welfare through the Korea Health
   Industry Development Institute [HI14C0558]; Korea Health Promotion
   Institute [HI14C0558010017] Funding Source: Korea Institute of Science &
   Technology Information (KISTI), National Science & Technology
   Information Service (NTIS)
FX This work was supported by the grant of Convergence of Conventional
   Medicine and Traditional Korean Medicine R&D program funded by the
   Ministry of Health and Welfare through the Korea Health Industry
   Development Institute (HI14C0558).
CR Abu-Shanab A, 2010, NAT REV GASTRO HEPAT, V7, P691, DOI 10.1038/nrgastro.2010.172
   ASFARI M, 1992, ENDOCRINOLOGY, V130, P167, DOI 10.1210/en.130.1.167
   Bajzer M, 2006, NATURE, V444, P1009, DOI 10.1038/4441009a
   Bell DSH, 2010, SOUTH MED J, V103, P265, DOI 10.1097/SMJ.0b013e3181ce0e4d
   Bosi E, 2009, DIABETES OBES METAB, V11, P3, DOI 10.1111/j.1463-1326.2008.01031.x
   Bosi E, 2009, DIABETES OBES METAB, V11, P506, DOI 10.1111/j.1463-1326.2009.01040.x
   Bouchoucha M, 2011, DIABETES METAB, V37, P90, DOI 10.1016/j.diabet.2010.11.002
   Bugianesi E, 2005, AM J GASTROENTEROL, V100, P1082, DOI 10.1111/j.1572-0241.2005.41583.x
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   Cani PD, 2016, MOL METAB, V5, P743, DOI 10.1016/j.molmet.2016.05.011
   Caporaso JG, 2010, NAT METHODS, V7, P335, DOI 10.1038/nmeth.f.303
   Daval M, 2006, J PHYSIOL-LONDON, V574, P55, DOI 10.1113/jphysiol.2006.111484
   Flint HJ, 2012, NAT REV GASTRO HEPAT, V9, P577, DOI 10.1038/nrgastro.2012.156
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   Fukui Hiroshi, 2015, Microorganisms, V3, P759, DOI 10.3390/microorganisms3040759
   Han JM, 2015, PHYTOTHER RES, V29, P1616, DOI 10.1002/ptr.5413
   Hardie DG, 2012, NAT REV MOL CELL BIO, V13, P251, DOI 10.1038/nrm3311
   Hardie DG, 1997, BIOCHEM SOC T, V25, P1229, DOI 10.1042/bst0251229
   Hur KY, 2015, DIABETES METAB J, V39, P198, DOI 10.4093/dmj.2015.39.3.198
   Jeon SM, 2016, EXP MOL MED, V48, DOI 10.1038/emm.2016.81
   Langille MGI, 2013, NAT BIOTECHNOL, V31, P814, DOI 10.1038/nbt.2676
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Lin HZ, 2000, NAT MED, V6, P998, DOI 10.1038/79697
   Linden MA, 2014, AM J PHYSIOL-ENDOC M, V306, pE300, DOI 10.1152/ajpendo.00427.2013
   Lu K, 2014, CHEM RES TOXICOL, V27, P172, DOI 10.1021/tx400454z
   Lynch SV, 2013, GUT MICROBES, V4, P41, DOI 10.4161/gmic.22430
   Manco M, 2017, J PEDIATR-US, V180, P31, DOI 10.1016/j.jpeds.2016.08.101
   Michael U Adikwu, 2010, J Basic Clin Pharm, V1, P197
   Michail S, 2015, FEMS MICROBIOL ECOL, V91, DOI 10.1093/femsec/fiu002
   Minamiyama Y, 2007, BIOFACTORS, V30, P91, DOI 10.1002/biof.5520300203
   Moran TH, 2006, DEV PSYCHOBIOL, V48, P360, DOI 10.1002/dev.20149
   Morgan AE, 2016, AGEING RES REV, V27, P108, DOI 10.1016/j.arr.2016.03.008
   Peng LY, 2000, FITOTERAPIA, V71, P713, DOI 10.1016/S0367-326X(00)00212-4
   Qian WB, 2016, YONAGO ACTA MED, V59, P67
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Raman M, 2013, CLIN GASTROENTEROL H, V11, P868, DOI 10.1016/j.cgh.2013.02.015
   Rector RS, 2010, J HEPATOL, V52, P727, DOI 10.1016/j.jhep.2009.11.030
   Schnabl B, 2014, GASTROENTEROLOGY, V146, P1513, DOI 10.1053/j.gastro.2014.01.020
   Segata N, 2011, GENOME BIOL, V12, DOI 10.1186/gb-2011-12-6-r60
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Song MY, 2014, J GINSENG RES, V38, P106, DOI 10.1016/j.jgr.2013.12.004
   Sulaiman M. R., 2008, RES J PHARM, V2, P38
   Teng Y, 2010, J NAT MED-TOKYO, V64, P288, DOI 10.1007/s11418-010-0405-x
   Tsai Franklin, 2009, Curr Gastroenterol Rep, V11, P307, DOI 10.1007/s11894-009-0045-z
   Tsuzuki T, 2015, FASEB J, V29
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Tzeng TF, 2015, NUTRIENTS, V7, P8670, DOI 10.3390/nu7105423
   Tzeng TF, 2014, PLANTA MED, V80, P121, DOI 10.1055/s-0033-1360196
   U.S. Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research (CDER), 2005, PHARMACOL TOXICOL
   Um SH, 2004, NATURE, V431, P200, DOI 10.1038/nature02866
   van Best N, 2015, HEPATOL INT, V9, P406, DOI 10.1007/s12072-015-9640-2
   Wan CW, 2013, PHYTOTHER RES, V27, P545, DOI 10.1002/ptr.4751
   Wang X.D., 2014, J APPL MATH, V2014, P9, DOI DOI 10.1371/J0URNAL.P0NE.0086117
   Wong VWS, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0062885
   Woo SL, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0091111
   Xue P, 2011, BIOCHEM BIOPH RES CO, V407, P360, DOI 10.1016/j.bbrc.2011.03.024
   Yoon SH, 2007, BIOL PHARM BULL, V30, P2196, DOI 10.1248/bpb.30.2196
   You M, 2004, GASTROENTEROLOGY, V127, P1798, DOI 10.1053/j.gastro.2004.09.049
   Zhang A, 2013, OBES REV, V14, P344, DOI 10.1111/obr.12011
   Zhou GC, 2001, J CLIN INVEST, V108, P1167, DOI 10.1172/JCI200113505
   Zhu LX, 2015, PEDIATR RES, V77, P245, DOI 10.1038/pr.2014.157
   Zhu LX, 2013, HEPATOLOGY, V57, P601, DOI 10.1002/hep.26093
NR 63
TC 31
Z9 33
U1 0
U2 18
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-302X
J9 FRONT MICROBIOL
JI Front. Microbiol.
PD NOV 17
PY 2017
VL 8
AR 2271
DI 10.3389/fmicb.2017.02271
PG 16
WC Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology
GA FM9LB
UT WOS:000415589600001
PM 29204141
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Zhang, MC
   Feng, RL
   Yang, M
   Qian, C
   Wang, Z
   Liu, W
   Ma, J
AF Zhang, Minchun
   Feng, Rilu
   Yang, Mei
   Qian, Cheng
   Wang, Zheng
   Liu, Wei
   Ma, Jing
TI Effects of metformin, acarbose, and sitagliptin monotherapy on gut
   microbiota in Zucker diabetic fatty rats
SO BMJ OPEN DIABETES RESEARCH & CARE
LA English
DT Article
ID METAGENOME; BACTERIA; OBESITY; ALTERS; ACIDS
AB Objective Recent studies have demonstrated that gut microbiota was closely related to metabolic disorders such as type 2 diabetes. Oral antidiabetic medications including metformin, acarbose and sitagliptin lowered blood glucose levels via acting on the gastrointestinal tract. The aim of the study was to observe the comparisons among those medications on gut microbiota composition.
   Research design and methods Zucker diabetic fatty rats (n=32) were randomly divided into four groups, and had respectively gastric administration of normal saline (control), metformin (215.15 mg/kg/day), acarbose (32.27 mg/kg/day), or sitagliptin (10.76 mg/kg/day) for 4 weeks. Blood glucose levels were measured during an intragastric starch tolerance test after the treatments. 16S rRNA gene sequencing was used to access the microbiota in the fecal samples.
   Results Metformin, acarbose, and sitagliptin monotherapy effectively decreased fasting and postprandial blood glucose levels (p<0.001). Acarbose group displayed specific cluster and enterotype mainly composed by Ruminococcus 2 while Lactobacillus was the dominant bacterium in the enterotype of the other three groups. The relative abundance of genera Ruminococcus 2 and Bifidobacterium was dramatically higher in acarbose group. Metformin and sitagliptin increased the relative abundance of genus Lactobacillus. Metagenomic prediction showed that the functional profiles of carbohydrate metabolism were enriched in acarbose group.
   Conclusions Metformin, acarbose and sitagliptin exerted different effects on the composition of gut microbiota and selectively increased the beneficial bacteria. Supplementation with specific probiotics may further improve the hypoglycemic effects of the antidiabetic drugs.
C1 [Zhang, Minchun; Feng, Rilu; Yang, Mei; Qian, Cheng; Liu, Wei; Ma, Jing] Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Dept Endocrinol & Metab, Shanghai, Peoples R China.
   [Wang, Zheng] Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Dept Gastrointestinal Surg, Shanghai, Peoples R China.
C3 Shanghai Jiao Tong University; Shanghai Jiao Tong University
RP Liu, W; Ma, J (通讯作者)，Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Dept Endocrinol & Metab, Shanghai, Peoples R China.
EM sue_liuwei@163.com; cherry1996@live.cn
OI Ma, Jing/0000-0003-1098-945X
FU National Natural Science Foundation of China [NSFC81670728]; Shanghai
   Municipal Education Commission-Gaofeng Clinical Medicine Grant Support
   [20181807]; Clinical Research Funding in Renji Hospital affiliated to
   Shanghai Jiao Tong University [PYZY16-020]
FX This work was supported by the National Natural Science Foundation of
   China (grant number NSFC81670728), the Shanghai Municipal Education
   Commission-Gaofeng Clinical Medicine Grant Support (grant number
   20181807) and the Clinical Research Funding in Renji Hospital affiliated
   to Shanghai Jiao Tong University (grant number PYZY16-020).
CR Aron-Wisnewsky J, 2012, NAT REV GASTRO HEPAT, V9, P590, DOI 10.1038/nrgastro.2012.161
   Arumugam M, 2011, NATURE, V473, P174, DOI 10.1038/nature09944
   Bai J, 2016, J ETHNOPHARMACOL, V194, P717, DOI 10.1016/j.jep.2016.10.043
   Bauer PV, 2018, CELL METAB, V27, P101, DOI 10.1016/j.cmet.2017.09.019
   Bhute SS, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.00214
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   De-Souza DA, 2005, CRIT CARE MED, V33, P1125, DOI 10.1097/01.CCM.0000162680.52397.97
   Duncan SH, 2007, APPL ENVIRON MICROB, V73, P1073, DOI 10.1128/AEM.02340-06
   Fernandes J, 2014, NUTR DIABETES, V4, DOI 10.1038/nutd.2014.23
   Gu YY, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-01682-2
   Hartstra AV, 2015, DIABETES CARE, V38, P159, DOI 10.2337/dc14-0769
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Koh A, 2016, CELL, V165, P1332, DOI 10.1016/j.cell.2016.05.041
   Kyriachenko Y, 2019, WORLD J DIABETES, V10, P154, DOI 10.4239/wjd.v10.i3.154
   La Reau AJ, 2016, MICROB GENOMICS, V2, DOI 10.1099/mgen.0.000099
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Le Kim-Anne, 2012, Front Physiol, V3, P496, DOI 10.3389/fphys.2012.00496
   Lebovitz HE, 1997, ENDOCRIN METAB CLIN, V26, P539, DOI 10.1016/S0889-8529(05)70266-8
   Lee DM, 2018, CARDIOVASC DIABETOL, V17, DOI 10.1186/s12933-018-0708-x
   Montandon SA, 2017, GENES-BASEL, V8, DOI 10.3390/genes8100250
   Musso G, 2010, DIABETES CARE, V33, P2277, DOI 10.2337/dc10-0556
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Simon MC, 2015, DIABETES CARE, V38, P1827, DOI 10.2337/dc14-2690
   Sivaprakasam S, 2016, PHARMACOL THERAPEUT, V164, P144, DOI 10.1016/j.pharmthera.2016.04.007
   Su BL, 2015, J DIABETES, V7, P729, DOI 10.1111/1753-0407.12232
   Tan KM, 2018, PROTEIN SCI, V27, P1498, DOI 10.1002/pro.3444
   Viollet B, 2012, CLIN SCI, V122, P253, DOI 10.1042/CS20110386
   Wang L, 2016, SCI REP-UK, V6, DOI [10.1038/srep38380, 10.1038/srep33251, 10.1038/srep20004]
   Warren FJ, 2018, MSPHERE, V3, DOI 10.1128/mSphere.00086-18
   Weng JP, 2016, DIABETES-METAB RES, V32, P442, DOI 10.1002/dmrr.2827
   Whang A, 2019, EBIOMEDICINE, V39, P591, DOI 10.1016/j.ebiom.2018.11.046
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Yadav H, 2007, NUTRITION, V23, P62, DOI 10.1016/j.nut.2006.09.002
   Yan X, 2016, J DIABETES RES, V2016, P1, DOI DOI 10.1155/2016/2093171
   Zaunmuller T, 2006, APPL MICROBIOL BIOT, V72, P421, DOI 10.1007/s00253-006-0514-3
   Zhang JP, 2016, J DIABETES, V8, P559, DOI 10.1111/1753-0407.12337
   Zhang Q, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0184735
   Zhang Q, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0079697
   Zhang XY, 2017, DIABETES THER, V8, P293, DOI 10.1007/s13300-017-0226-y
   Zhao L, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00233
   Zhou W, 2019, FRONT MICROBIOL, V10, DOI 10.3389/fmicb.2019.00232
NR 41
TC 42
Z9 44
U1 1
U2 10
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
EI 2052-4897
J9 BMJ OPEN DIAB RES CA
JI BMJ Open Diab. Res. Care
PD OCT
PY 2019
VL 7
IS 1
AR e000717
DI 10.1136/bmjdrc-2019-000717
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA KB0KF
UT WOS:000506187100031
PM 31641523
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Shin, NR
   Lee, JC
   Lee, HY
   Kim, MS
   Whon, TW
   Lee, MS
   Bae, JW
AF Shin, Na-Ri
   Lee, June-Chul
   Lee, Hae-Youn
   Kim, Min-Soo
   Whon, Tae Woong
   Lee, Myung-Shik
   Bae, Jin-Woo
TI An increase in the Akkermansia spp. population induced by metformin
   treatment improves glucose homeostasis in diet-induced obese mice
SO GUT
LA English
DT Article
ID ADIPOSE-TISSUE INFLAMMATION; GUT MICROBIOTA; INSULIN-RESISTANCE;
   T-CELLS; METABOLIC SYNDROME; UNIQUE POPULATION; LINKING OBESITY; FAT;
   MUCIN; MODULATION
AB Background Recent evidence indicates that the composition of the gut microbiota contributes to the development of metabolic disorders by affecting the physiology and metabolism of the host. Metformin is one of the most widely prescribed type 2 diabetes (T2D) therapeutic agents.
   Objective To determine whether the antidiabetic effect of metformin is related to alterations of intestinal microbial composition.
   Design C57BL/6 mice, fed either a normal-chow diet or a high-fat diet (HFD), were treated with metformin for 6 weeks. The effect of metformin on the composition of the gut microbiota was assessed by analysing 16S rRNA gene sequences with 454 pyrosequencing. Adipose tissue inflammation was examined by flow cytometric analysis of the immune cells present in visceral adipose tissue (VAT).
   Results Metformin treatment significantly improved the glycaemic profile of HFD-fed mice. HFD-fed mice treated with metformin showed a higher abundance of the mucin-degrading bacterium Akkermansia than HFD-fed control mice. In addition, the number of mucin-producing goblet cells was significantly increased by metformin treatment (p < 0.0001). Oral administration of Akkermansia muciniphila to HFD-fed mice without metformin significantly enhanced glucose tolerance and attenuated adipose tissue inflammation by inducing Foxp3 regulatory T cells (Tregs) in the VAT.
   Conclusions Modulation of the gut microbiota (by an increase in the Akkermansia spp. population) may contribute to the antidiabetic effects of metformin, thereby providing a new mechanism for the therapeutic effect of metformin in patients with T2D. This suggests that pharmacological manipulation of the gut microbiota in favour of Akkermansia may be a potential treatment for T2D.
C1 [Shin, Na-Ri; Kim, Min-Soo; Whon, Tae Woong; Bae, Jin-Woo] Kyung Hee Univ, Dept Life & Nanopharmaceut Sci, Seoul 130701, South Korea.
   [Shin, Na-Ri; Kim, Min-Soo; Whon, Tae Woong; Bae, Jin-Woo] Kyung Hee Univ, Dept Biol, Seoul 130701, South Korea.
   [Lee, June-Chul; Lee, Hae-Youn; Lee, Myung-Shik] Sungkyunkwan Univ, Sch Med, Dept Med, Samsung Med Ctr, Seoul 135710, South Korea.
   [Lee, June-Chul; Lee, Hae-Youn; Lee, Myung-Shik] Sungkyunkwan Univ, Sch Med, Dept Biotechnol & Bioengn, Samsung Med Ctr, Seoul 135710, South Korea.
C3 Kyung Hee University; Kyung Hee University; Sungkyunkwan University
   (SKKU); Samsung Medical Center; Sungkyunkwan University (SKKU); Samsung
   Medical Center
RP Bae, JW (通讯作者)，Kyung Hee Univ, Dept Life & Nanopharmaceut Sci, Seoul 130701, South Korea.
EM mslee0923@skku.edu; baejw@khu.ac.kr
RI Lee, Myung Shik/C-9606-2011; Bae, Jin-Woo/S-1955-2017
OI Bae, Jin-Woo/0000-0001-6433-5270
FU National Research Foundation of Korea (NRF) - Ministry of Education,
   Science and Technology (MEST) [2011-0028854]; Bio RD Program
   [2008-04090]; National Research Foundation of Korea
   [K21004000003-12A0500-00310]
FX This work was supported by a grant from the Mid-Career Researcher
   Program (2011-0028854 to J-WB) through the National Research Foundation
   of Korea (NRF), funded by the Ministry of Education, Science and
   Technology (MEST) and by the Bio R&D Program (2008-04090 to M-SL). M-SL
   is the recipient of a global research laboratory grant from the National
   Research Foundation of Korea (K21004000003-12A0500-00310).
CR Artis D, 2004, P NATL ACAD SCI USA, V101, P13596, DOI 10.1073/pnas.0404034101
   Backhed F, 2004, P NATL ACAD SCI USA, V101, P15718, DOI 10.1073/pnas.0407076101
   Backhed F, 2005, SCIENCE, V307, P1915, DOI 10.1126/science.1104816
   Backhed F, 2007, P NATL ACAD SCI USA, V104, P979, DOI 10.1073/pnas.0605374104
   Bailey CJ, 2008, DIABETOLOGIA, V51, P1552, DOI 10.1007/s00125-008-1053-5
   BAILEY CJ, 1994, BRIT J PHARMACOL, V112, P671, DOI 10.1111/j.1476-5381.1994.tb13128.x
   Bailey CJ, 1996, NEW ENGL J MED, V334, P574, DOI 10.1056/NEJM199602293340906
   Cai DS, 2005, NAT MED, V11, P183, DOI 10.1038/nm1166
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Carvalho BM, 2012, DIABETOLOGIA, V55, P2823, DOI 10.1007/s00125-012-2648-4
   Cipolletta D, 2011, SEMIN IMMUNOL, V23, P431, DOI 10.1016/j.smim.2011.06.002
   Cusi K, 1998, DIABETES REV, V6, P89
   Derrien M, 2004, INT J SYST EVOL MICR, V54, P1469, DOI 10.1099/ijs.0.02873-0
   Derrien M, 2011, FRONT MICROBIOL, V2, DOI 10.3389/fmicb.2011.00166
   Dethlefsen L, 2008, PLOS BIOL, V6, P2383, DOI 10.1371/journal.pbio.0060280
   Donnelly LA, 2006, DIABETIC MED, V23, P128, DOI 10.1111/j.1464-5491.2005.01755.x
   Elgazar-Carmon V, 2008, J LIPID RES, V49, P1894, DOI 10.1194/jlr.M800132-JLR200
   Everard A, 2011, DIABETES, V60, P2775, DOI 10.2337/db11-0227
   Feuerer M, 2009, NAT MED, V15, P930, DOI 10.1038/nm.2002
   Furuhashi M, 2008, J CLIN INVEST, V118, P2640, DOI 10.1172/JCI34750
   Guilherme A, 2008, NAT REV MOL CELL BIO, V9, P367, DOI 10.1038/nrm2391
   Hansen CHF, 2013, EUR J IMMUNOL, V43, P447, DOI 10.1002/eji.201242462
   He L, 2009, CELL, V137, P635, DOI 10.1016/j.cell.2009.03.016
   Jumpertz R, 2011, AM J CLIN NUTR, V94, P58, DOI 10.3945/ajcn.110.010132
   Kahn SE, 2006, NATURE, V444, P840, DOI 10.1038/nature05482
   Kim DH, 2011, J IMMUNOL, V187, P5211, DOI 10.4049/jimmunol.1001388
   Knights D, 2011, ISME J, V5, P570, DOI 10.1038/ismej.2010.148
   Koren O, 2011, P NATL ACAD SCI USA, V108, P4592, DOI 10.1073/pnas.1011383107
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Ley RE, 2005, P NATL ACAD SCI USA, V102, P11070, DOI 10.1073/pnas.0504978102
   Ley RE, 2006, NATURE, V444, P1022, DOI 10.1038/4441022a
   Liou AP, 2013, SCI TRANSL MED, V5, DOI 10.1126/scitranslmed.3005687
   Liu GW, 2011, IMMUNOL CELL BIOL, V89, P130, DOI 10.1038/icb.2010.70
   McDole JR, 2012, NATURE, V483, P345, DOI 10.1038/nature10863
   Membrez M, 2008, FASEB J, V22, P2416, DOI 10.1096/fj.07-102723
   Nishimura S, 2009, NAT MED, V15, P914, DOI 10.1038/nm.1964
   Png CW, 2010, AM J GASTROENTEROL, V105, P2420, DOI 10.1038/ajg.2010.281
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Rokholm B, 2010, OBES REV, V11, P835, DOI 10.1111/j.1467-789X.2010.00810.x
   Santacruz A, 2010, BRIT J NUTR, V104, P83, DOI 10.1017/S0007114510000176
   Shaw RJ, 2005, SCIENCE, V310, P1642, DOI 10.1126/science.1120781
   SUEMORI S, 1991, P NATL ACAD SCI USA, V88, P11017, DOI 10.1073/pnas.88.24.11017
   Swidsinski A, 2011, GUT, V60, P34, DOI 10.1136/gut.2009.191320
   Tilg H, 2010, J CLIN GASTROENTEROL, V44, pS16, DOI 10.1097/MCG.0b013e3181dd8b64
   Turnbaugh PJ, 2008, CELL HOST MICROBE, V3, P213, DOI 10.1016/j.chom.2008.02.015
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Van den Abbeele P, 2011, ENVIRON MICROBIOL, V13, P2667, DOI 10.1111/j.1462-2920.2011.02533.x
   Vijay-Kumar M, 2010, SCIENCE, V328, P228, DOI 10.1126/science.1179721
   Wang YF, 2008, OBESITY, V16, P2323, DOI 10.1038/oby.2008.351
   Weisberg SP, 2003, J CLIN INVEST, V112, P1796, DOI 10.1172/JCI200319246
   WILCOCK C, 1994, XENOBIOTICA, V24, P49, DOI 10.3109/00498259409043220
   Winer S, 2012, IMMUNOL CELL BIOL, V90, P755, DOI 10.1038/icb.2011.110
   Xu HY, 2003, J CLIN INVEST, V112, P1821, DOI 10.1172/JCI200319451
   Zhou GC, 2001, J CLIN INVEST, V108, P1167, DOI 10.1172/JCI200113505
NR 54
TC 1018
Z9 1085
U1 21
U2 403
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0017-5749
EI 1468-3288
J9 GUT
JI Gut
PD MAY
PY 2014
VL 63
IS 5
BP 727
EP 735
DI 10.1136/gutjnl-2012-303839
PG 9
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA AF0GX
UT WOS:000334393400007
PM 23804561
HC Y
HP N
DA 2023-06-08
ER

PT J
AU Xu, YX
   Zheng, SY
   Jiang, S
   Chen, JY
   Zhu, XF
   Zhang, Y
AF Xu, Yunxi
   Zheng, Shuyu
   Jiang, Shui
   Chen, Junyu
   Zhu, Xiaofang
   Zhang, Ya
TI The effect of Chinese herbal formulas combined with metformin on
   modulating the gut microbiota in the amelioration of type 2 diabetes
   mellitus: A systematic review and meta-analysis
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE type 2 diabetes mellitus; gut microbiota; metformin; Chinese herbal
   formula; combination treatment; meta-analysis
ID GEGEN QINLIAN DECOCTION; SHENLING BAIZHU POWDER; DOUBLE-BLIND;
   EXPERIMENTAL COLITIS; INSULIN-RESISTANCE; GLUCOSE-TOLERANCE; MEDICINE;
   RATS; PHARMACOKINETICS; INFLAMMATION
AB To assess and analyse the effectiveness and safety of combined Chinese herbal formula (CHF) and metformin treatment in the modulation of the gut microbiota in the amelioration of type 2 diabetes mellitus(T2DM), all publications addressing the effect of this combination treatment on the quantitative alterations in the gut microbiota and glucose parameters were collected. Rob tool in the Cochrane handbook was performed to evaluate the methodological quality of all included studies. Relevant information and statistics were abstracted and synthesized in Review Manager 5.4 to evaluate the efficacy of combination treatment. Sensitivity analyses and subgroup analyses were used to analyse the sources of heterogeneity. Publication bias analyses were performed by Stata software to assess the robustness and quality of the outcomes. As a result, a total of 12 eligible RCTs with 1307 T2DM participants from 7 electronic databases were included. Combined CHF with metformin treatment showed better efficacies than metformin monotherapy in regulating the structure of the gut microbiota, characterized by increased Bifidobacterium, Lactobacillus and Bacteroidetes and decreased Enterobacteriaceae, Enterococcus, and Saccharomyces along with better decreases in glycated haemoglobin, fasting plasma glucose, 2-hour postprandial blood glucose, fasting insulin and homeostasis model assessment of insulin resistance. Subgroup analyses further analysed the effect of metformin doses and CHF classifications on controlling hyperglycaemia and altering the gut microbiota. In conclusion, our meta-analysis suggested that combined CHF with metformin treatment is promising for the modulation of the gut microbiota along with ameliorating hyperglycemia in T2DM patients. Importantly, more well-designed RCTs are needed to validate the outcomes and verify the treatment value for clinical purposes.
C1 [Xu, Yunxi; Zheng, Shuyu; Jiang, Shui; Chen, Junyu; Zhu, Xiaofang; Zhang, Ya] Chengdu Univ Tradit Chinese Med, Hosp Chengdu Univ Tradit Chinese Med, Chengdu, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine
RP Zhang, Y (通讯作者)，Chengdu Univ Tradit Chinese Med, Hosp Chengdu Univ Tradit Chinese Med, Chengdu, Peoples R China.
EM zhangya19780711@163.com
FU Sichuan Provincial Administration of Traditional Chinese Medicine; 
   [2021MS457]
FX Funding This research was supported by the Sichuan Provincial
   Administration of Traditional Chinese Medicine (Grant Number:
   2021MS457).
CR Adeshirlarijaney A, 2020, GUT MICROBES, V11, P253, DOI 10.1080/19490976.2020.1717719
   Bruno RV, 2007, FERTIL STERIL, V88, P510, DOI 10.1016/j.fertnstert.2006.11.133
   Campagnoli C, 2012, CLIN BREAST CANCER, V12, P175, DOI 10.1016/j.clbc.2012.03.004
   Campbell MD, 2020, NAT REV ENDOCRINOL, V16, P395, DOI 10.1038/s41574-019-0316-1
   Canfora EE, 2019, NAT REV ENDOCRINOL, V15, P261, DOI 10.1038/s41574-019-0156-z
   Cani PD, 2009, GUT, V58, P1091, DOI 10.1136/gut.2008.165886
   Cani PD, 2012, GUT MICROBES, V3, P279, DOI 10.4161/gmic.19625
   Cao YS, 2019, PHARM BIOL, V57, P660, DOI 10.1080/13880209.2019.1659831
   Cao ZB, 2021, J ETHNOPHARMACOL, V264, DOI 10.1016/j.jep.2020.113289
   Chaudhari K, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0234571
   Chen Q., 2021, CHIN MANIPULATION RE, V12, P23, DOI [10.19787/j.issn.1008-1879.2021.15.008, DOI 10.19787/J.ISSN.1008-1879.2021.15.008]
   Chen W, 2016, J INFLAMM-LOND, V13, DOI 10.1186/s12950-016-0142-3
   Chen WP, 2015, INT J OPHTHALMOL-CHI, V8, P1094, DOI 10.3980/j.issn.2222-3959.2015.06.03
   Chen Z, 2019, FUJIAN U TRADITIONAL, V08, P01
   Cui L, 2014, INT IMMUNOPHARMACOL, V23, P294, DOI 10.1016/j.intimp.2014.09.005
   [戴丛书 Dai Congshu], 2019, [中国实验方剂学杂志, Chinese Journal of Experimental Traditional Medical Formulae], V25, P83
   Fan Y, 2021, NAT REV MICROBIOL, V19, P55, DOI 10.1038/s41579-020-0433-9
   Fava S, 2014, CURR DIABETES REV, V10, P302, DOI 10.2174/1573399810666141030125830
   Feng WW, 2019, PHARMACOL RES, V142, P176, DOI 10.1016/j.phrs.2019.02.024
   Feng X-G., 2016, W J INTEG TRAD W MED, V11, P1110, DOI [10.13935/j.cnki.sjzx.160820, DOI 10.13935/J.CNKI.SJZX.160820]
   Foretz M, 2010, J CLIN INVEST, V120, P2355, DOI 10.1172/JCI40671
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Garza-Ocanas L, 2019, ADV THER, V36, P407, DOI 10.1007/s12325-018-0853-3
   Graham GG, 2011, CLIN PHARMACOKINET, V50, P81, DOI 10.2165/11534750-000000000-00000
   Gu LY, 2021, J ETHNOPHARMACOL, V281, DOI 10.1016/j.jep.2020.113548
   Han K, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0182467
   Higgins JPT, 2011, BMJ-BRIT MED J, V343, DOI 10.1136/bmj.d5928
   Hu RF, 2017, CHIN J NAT MEDICINES, V15, P436, DOI 10.1016/S1875-5364(17)30065-1
   Hu Y, 2016, COMPLEMENT THER MED, V24, P13, DOI 10.1016/j.ctim.2015.11.005
   Huang ZQ, 2017, ACTA PHARMACOL SIN, V38, P1141, DOI 10.1038/aps.2016.165
   Ianiro G, 2016, GUT, V65, P1906, DOI 10.1136/gutjnl-2016-312297
   Jiang H., 2020, J GANSU SCI, V32, P9, DOI [10.16468/j.cnki.issn1004-0366.2020.06.002, DOI 10.16468/J.CNKI.ISSN1004-0366.2020.06.002]
   Jin D, 2019, EVID-BASED COMPL ALT, V2019, DOI 10.1155/2019/1825750
   Kanto K, 2018, J DIABETES INVEST, V9, P587, DOI 10.1111/jdi.12755
   Koh A, 2016, CELL, V165, P1332, DOI 10.1016/j.cell.2016.05.041
   Li H., 2018, HUNAN J TRADITIONAL, V34, P65, DOI [10.16808/j.cnki.issn1003-7705.2018.08.029, DOI 10.16808/J.CNKI.ISSN1003-7705.2018.08.029]
   [李吉武 Li Jiwu], 2015, [中医杂志, Journal of Traditional Chinese Medicine], V56, P409
   Li RY, 2016, PHYTOMEDICINE, V23, P1012, DOI 10.1016/j.phymed.2016.06.010
   Li SH, 2021, AM J TRANSL RES, V13, P9701
   Li Y-c., 2019, STRAIT PHARM J, V31, P165
   Lian FM, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0130550
   Lian FM, 2014, J CLIN ENDOCR METAB, V99, P648, DOI 10.1210/jc.2013-3276
   Lin Z, 2015, NAT PROD RES, V29, P1194, DOI 10.1080/14786419.2014.995652
   Liu CS, 2019, BIOMED CHROMATOGR, V33, DOI 10.1002/bmc.4421
   Liu X, 2017, LIAONING J TRADIT CH, V44, P2311, DOI DOI 10.13192/J.ISSN.1000-1719.2017.11.023
   Liu XY, 2021, J EXP CLIN CANC RES, V40, DOI 10.1186/s13046-021-01983-x
   Liu XM, 2020, PHARM BIOL, V58, P1123, DOI 10.1080/13880209.2020.1844242
   Lu JZ, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.668418
   Magkos F, 2020, NAT REV ENDOCRINOL, V16, P545, DOI 10.1038/s41574-020-0381-5
   Meng M, 2021, BIOMED RES INT, V2021, DOI 10.1155/2021/4579850
   Moher D, 2009, J CLIN EPIDEMIOL, V62, P1006, DOI 10.1016/j.jclinepi.2009.06.005
   Nishimura R, 2022, ADV THER, V39, P632, DOI 10.1007/s12325-021-01979-1
   Pan LL, 2020, J ETHNOPHARMACOL, V258, DOI 10.1016/j.jep.2020.112842
   Permutt MA, 2005, J CLIN INVEST, V115, P1431, DOI 10.1172/JCI24758
   Ren DD, 2017, CHIN J NAT MEDICINES, V15, P847, DOI 10.1016/S1875-5364(18)30018-9
   Rena G, 2017, DIABETOLOGIA, V60, P1577, DOI 10.1007/s00125-017-4342-z
   Scheithauer TPM, 2020, FRONT IMMUNOL, V11, DOI 10.3389/fimmu.2020.571731
   Sharma N, 2020, J NUTR BIOCHEM, V84, DOI 10.1016/j.jnutbio.2020.108442
   Sharma S, 2019, J NUTR BIOCHEM, V63, P101, DOI 10.1016/j.jnutbio.2018.10.003
   Shi R, 2019, EUR J PHARM SCI, V127, P282, DOI 10.1016/j.ejps.2018.11.010
   Shin NR, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.02271
   Shin NR, 2020, AM J PHYSIOL-ENDOC M, V318, pE52, DOI 10.1152/ajpendo.00221.2019
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Tang A., 2021, FUJIAN U TRADITIONAL, V01, P01, DOI [10.27021/d.cnki.gfjzc.2021.000331, DOI 10.27021/D.CNKI.GFJZC.2021.000331]
   Tang J, 2021, IRAN J PUBLIC HEALTH, V50, P2191, DOI 10.18502/ijph.v50i11.7573
   Tang KR, 2020, OXID MED CELL LONGEV, V2020, DOI 10.1155/2020/9701285
   Tong XL, 2013, DIABETES OBES METAB, V15, P448, DOI 10.1111/dom.12051
   Tong XL, 2018, MBIO, V9, DOI 10.1128/mBio.02392-17
   Wang D., 2008, MODERN PREVENTIVE ME, V35, P2819, DOI [10.3969/j.issn.1003-8507.2008.15.002, DOI 10.3969/J.ISSN.1003-8507.2008.15.002]
   Wang K, 2018, NUTRIENTS, V10, DOI 10.3390/nu10060791
   Wang XY, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.642685
   Warmbrunn MV, 2020, EXPERT REV ENDOCRINO, V15, P13, DOI 10.1080/17446651.2020.1720511
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Xiao Y, 2021, CHIN J INTEGR MED, V27, P206, DOI 10.1007/s11655-020-3259-4
   Xu J, 2015, ISME J, V9, P552, DOI 10.1038/ismej.2014.177
   Xu XY, 2020, J ETHNOPHARMACOL, V262, DOI 10.1016/j.jep.2020.113129
   Xu XZ, 2020, GENOM PROTEOM BIOINF, V18, P721, DOI [10.1016/j.gpb.2019.09.0071672-0229, 10.1016/j.gpb.2019.09.007]
   Xu Y, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.649606
   Yadong L., 2020, ACTA CHIN MED, V35, P1312, DOI [10.16368/j.issn.1674-8999.2020.06.294, DOI 10.16368/J.ISSN.1674-8999.2020.06.294]
   Ye LF, 2016, LIFE SCI, V166, P82, DOI 10.1016/j.lfs.2016.09.025
   Yue SJ, 2019, PHARMACOL RES, V148, DOI 10.1016/j.phrs.2019.104453
   Zhang CH, 2013, PHYTOMEDICINE, V20, P221, DOI 10.1016/j.phymed.2012.11.002
   Zhang H, 2004, J COLLOID INTERF SCI, V279, P539, DOI 10.1016/j.jcis.2004.06.103
   Zhang Q, 2020, DIABET METAB SYND OB, V13, P5003, DOI 10.2147/DMSO.S286430
   Zhang XL, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000021894
   Zhang X, 2015, SCI REP-UK, V5, DOI 10.1038/srep14405
   Zhang X, 2012, PLOS ONE, V7, DOI [10.1371/journal.pone.0042529, 10.1371/journal.pone.0035700]
   Zhang Y, 2016, EVID-BASED COMPL ALT, V2016, DOI 10.1155/2016/1592731
   Zhang YF, 2008, J CLIN ENDOCR METAB, V93, P2559, DOI 10.1210/jc.2007-2404
   Zhang YP, 2018, BIOMED PHARMACOTHER, V102, P1025, DOI 10.1016/j.biopha.2018.03.158
   Zhao XT, 2015, EUR J CANCER PREV, V24, P27, DOI 10.1097/CEJ.0000000000000078
   Zhao YX, 2021, PHYTOMEDICINE, V84, DOI 10.1016/j.phymed.2021.153519
   Zheng JP, 2020, J ETHNOPHARMACOL, V248, DOI 10.1016/j.jep.2019.112330
   Zheng YJ, 2021, PHYTOMEDICINE, V88, DOI 10.1016/j.phymed.2020.153455
   Zhou H, 2017, BIOMED PHARMACOTHER, V89, P864, DOI 10.1016/j.biopha.2017.03.003
NR 95
TC 0
Z9 0
U1 6
U2 13
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD SEP 15
PY 2022
VL 13
AR 927959
DI 10.3389/fendo.2022.927959
PG 18
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 4Z5UY
UT WOS:000862274600001
PM 36187136
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Diez-Echave, P
   Vezza, T
   Algieri, F
   Ruiz-Malagon, AJ
   Hidalgo-Garcia, L
   Garcia, F
   Moron, R
   Sanchez, M
   Toral, M
   Romero, M
   Duarte, J
   Garrido-Mesa, J
   Rodriguez-Cabezas, ME
   Rodriguez-Nogales, A
   Galvez, J
AF Diez-Echave, Patricia
   Vezza, Teresa
   Algieri, Francesca
   Ruiz-Malagon, Antonio Jesus
   Hidalgo-Garcia, Laura
   Garcia, Federico
   Moron, Rocio
   Sanchez, Manuel
   Toral, Marta
   Romero, Miguel
   Duarte, Juan
   Garrido-Mesa, Jose
   Rodriguez-Cabezas, Maria Elena
   Rodriguez-Nogales, Alba
   Galvez, Julio
TI The melatonergic agonist agomelatine ameliorates high fat diet-induced
   obesity in mice through the modulation of the gut microbiome
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Agomelatine; Melatonin; Metabolism; Metformin; Microbiome; Obesity
ID INSULIN-RESISTANCE; METFORMIN; INFLAMMATION; ANTIOXIDANT; METABOLISM;
   AMPK; METAANALYSIS; ADIPONECTIN; MECHANISM; BUTYRATE
AB Background and purpose: Melatonin has shown beneficial effects on obesity, both in humans and experimental models, via regulating the altered circadian rhythm and thus ameliorating the gut dysbiosis associated with this metabolic condition. However, its clinical use is limited, mostly due to its short half-life. Agomelatine is an agonist of the melatonin receptors that could be used to manage obesity and offer a better profile than melatonin. Experimental approach: Male C57BL/6 mice were fed a high fat diet and orally treated for five weeks with agomelatine, or melatonin or metformin, used as control drugs. Metabolic profile, inflammatory status, vascular dysfunction and intestinal microbiota composition were assessed. Key results: Agomelatine lessened body weight gain, enhanced glucose and lipid metabolisms, and improved insulin resistance. It also reduced the obesity-associated inflammatory status and endothelial dysfunction, probably linked to its effect on gut dysbiosis, consisting of the restoration of bacterial populations with key functions, such as short chain fatty acid production. Conclusions and implications: Agomelatine can be considered as a novel therapeutic tool for the management of human obesity and its associated comorbidities.
C1 [Diez-Echave, Patricia; Vezza, Teresa; Algieri, Francesca; Ruiz-Malagon, Antonio Jesus; Hidalgo-Garcia, Laura; Sanchez, Manuel; Toral, Marta; Romero, Miguel; Duarte, Juan; Garrido-Mesa, Jose; Rodriguez-Cabezas, Maria Elena; Rodriguez-Nogales, Alba; Galvez, Julio] Univ Granada, Ctr Biomed Res CIBM, Dept Pharmacol, Granada 18071, Spain.
   [Diez-Echave, Patricia; Vezza, Teresa; Ruiz-Malagon, Antonio Jesus; Hidalgo-Garcia, Laura; Garcia, Federico; Moron, Rocio; Sanchez, Manuel; Toral, Marta; Romero, Miguel; Duarte, Juan; Rodriguez-Cabezas, Maria Elena; Rodriguez-Nogales, Alba; Galvez, Julio] Inst Invest Biosanitaria Granada ibs GRANADA, Granada 18012, Spain.
   [Garcia, Federico] Hosp Univ Clin San Cecilio, Serv Microbiol, Red Invest SIDA, Granada 18100, Spain.
   [Moron, Rocio] Hosp Univ Clin San Cecilio, Serv Farm Hosp, Granada 18100, Spain.
   [Romero, Miguel; Duarte, Juan] Ctr Invest Biomed Red Enfermedades Cardiovasc CIBE, Madrid, Spain.
   [Rodriguez-Nogales, Alba] Hosp Univ Virgen Nieves, Serv Digest, Granada 18012, Spain.
   [Galvez, Julio] Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid, Spain.
C3 University of Granada; Instituto de Investigacion Biosanitaria IBS
   Granada; CIBER - Centro de Investigacion Biomedica en Red; CIBERCV;
   Hospital Universitario Virgen de las Nieves; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEREHD
RP Garrido-Mesa, J; Rodriguez-Cabezas, ME (通讯作者)，Univ Granada, Ctr Biomed Res CIBM, Dept Pharmacol, Granada 18071, Spain.
EM josegarridomesa@gmail.com; merodri@ugr.es
RI Romero, Miguel/K-6053-2014; Garrido Mesa, Jose/AAP-3208-2020; Duarte,
   Juan/K-6472-2014; Toral, Marta/K-6709-2014; Algieri,
   Francesca/L-3231-2014
OI Romero, Miguel/0000-0003-0578-1099; Garrido Mesa,
   Jose/0000-0001-6420-9055; Duarte, Juan/0000-0002-9153-5857; Toral,
   Marta/0000-0001-5324-8569; Algieri, Francesca/0000-0002-0262-4867
FU Junta de Andalucia [CTS 164]; Instituto de Salud Carlos III
   [PI19/01058]; European Union
FX This work was supported by the Junta de Andalucia (CTS 164) and by
   Instituto de Salud Carlos III (PI19/01058) with funds from the European
   Union. T. Vezza is a postdoctoral fellow from Instituto de Investigacion
   Biosanitaria de Granada; P. Diez-Echave, F. Algieri and J. Garrido-Mesa
   are postdoctoral fellows from University of Granada; A.J. Ruiz-Malagon
   and L. Hidalgo-Garcia are predoctoral fellows from University of Granada
   ("Programa de Doctorado: Medicina Clinica y Salud Publica"). CIBER-EHD,
   CIBERCV and "Red de Investigacion en SIDA" are supported by Instituto de
   Salud Carlos III.
CR Abuqwider JN, 2021, MICROORGANISMS, V9, DOI 10.3390/microorganisms9051098
   Acuna-Castroviejo D, 2014, CELL MOL LIFE SCI, V71, P2997, DOI 10.1007/s00018-014-1579-2
   An Q, 2020, PHARMACOL BIOCHEM BE, V192, DOI 10.1016/j.pbb.2020.172910
   Anderson P., 2015, BIO-PROTOCOL, V5, pe1642, DOI [10.21769/BioProtoc.1642, DOI 10.21769/BIOPROTOC.1642]
   Bergey D. H., 2001, BERGEYS MANUAL SYSTE
   Braunersreuther V, 2012, WORLD J GASTROENTERO, V18, P727, DOI 10.3748/wjg.v18.i8.727
   Budhwar S, 2018, FRONT IMMUNOL, V9, DOI 10.3389/fimmu.2018.02776
   Challet E, 2019, NAT REV ENDOCRINOL, V15, P393, DOI 10.1038/s41574-019-0210-x
   Chamanara M, 2019, INFLAMMOPHARMACOLOGY, V27, P361, DOI 10.1007/s10787-018-0523-8
   Cherngwelling R, 2021, TOXICOL APPL PHARM, V425, DOI 10.1016/j.taap.2021.115601
   Chojnacki C, 2013, WORLD J GASTROENTERO, V19, P3602, DOI 10.3748/wjg.v19.i23.3602
   Cipolla-Neto J, 2014, J PINEAL RES, V56, P371, DOI 10.1111/jpi.12137
   Crovesy L, 2020, EUR J CLIN NUTR, V74, P1251, DOI 10.1038/s41430-020-0607-6
   Demirdas A, 2016, METAB BRAIN DIS, V31, P1445, DOI 10.1007/s11011-016-9874-2
   Dhariwal A, 2017, NUCLEIC ACIDS RES, V45, pW180, DOI 10.1093/nar/gkx295
   Diez-Echave P, 2020, FOOD RES INT, V127, DOI 10.1016/j.foodres.2019.108722
   Ellulu MS, 2017, ARCH MED SCI, V13, P851, DOI 10.5114/aoms.2016.58928
   Esteban-Zubero E, 2017, LIFE SCI, V170, P72, DOI 10.1016/j.lfs.2016.11.031
   Ferreira-Hermosillo A, 2020, TRIALS, V21, DOI 10.1186/s13063-020-4121-x
   Gao T, 2021, INT IMMUNOPHARMACOL, V96, DOI 10.1016/j.intimp.2021.107779
   Genario R, 2021, PHARMACOL RES, V163, DOI 10.1016/j.phrs.2020.105254
   Gonzalez FJ, 2017, EUR J CLIN PHARMACOL, V73, P1337, DOI 10.1007/s00228-017-2322-3
   Gorwood P, 2020, CLIN DRUG INVEST, V40, P1009, DOI 10.1007/s40261-020-00957-9
   Greenblum S, 2012, P NATL ACAD SCI USA, V109, P594, DOI 10.1073/pnas.1116053109
   Hayashi T, 2019, INT J UROL, V26, P307, DOI 10.1111/iju.13847
   Henagan TM, 2015, BRIT J PHARMACOL, V172, P2782, DOI 10.1111/bph.13058
   Herzig S, 2018, NAT REV MOL CELL BIO, V19, P121, DOI 10.1038/nrm.2017.95
   Hickie IB, 2011, LANCET, V378, P621, DOI 10.1016/S0140-6736(11)60095-0
   Hidalgo-Garcia L, 2021, ACTA PHYSIOL, V233, DOI 10.1111/apha.13699
   Hildebrandt MA, 2009, GASTROENTEROLOGY, V137, P1716, DOI 10.1053/j.gastro.2009.08.042
   Hussain MM, 2012, CURR OPIN CLIN NUTR, V15, P336, DOI 10.1097/MCO.0b013e3283548629
   Ji SQ, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00704
   Jing YY, 2018, MOL CELL ENDOCRINOL, V461, P256, DOI 10.1016/j.mce.2017.09.025
   Kessoku T, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22158161
   Le Chatelier E, 2013, NATURE, V500, P541, DOI 10.1038/nature12506
   Lee YH, 2003, J BIOL CHEM, V278, P2896, DOI 10.1074/jbc.M208359200
   Li M, 2017, MOL MED REP, V16, P680, DOI 10.3892/mmr.2017.6637
   Li YY, 2020, J PINEAL RES, V69, DOI 10.1111/jpi.12682
   Loloei S, 2019, DIABETES METAB SYND, V13, P1901, DOI 10.1016/j.dsx.2019.04.043
   Louis P, 2017, ENVIRON MICROBIOL, V19, P29, DOI 10.1111/1462-2920.13589
   Lu QG, 2019, BIOSCIENCE REP, V39, DOI 10.1042/BSR20181995
   Luther J, 2015, CELL MOL GASTROENTER, V1, P222, DOI 10.1016/j.jcmgh.2015.01.001
   Ma N, 2020, MED RES REV, V40, P606, DOI 10.1002/med.21628
   Mantele S, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0037123
   Mannino G, 2019, J PINEAL RES, V67, DOI 10.1111/jpi.12598
   de Farias TDM, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00750
   de Farias TDM, 2019, CELLS-BASEL, V8, DOI 10.3390/cells8091041
   Miao RY, 2022, FRONT PHYSIOL, V13, DOI 10.3389/fphys.2022.822333
   Milano W, 2013, Open Neurol J, V7, P32, DOI 10.2174/1874205X20130626001
   Muscogiuri Giovanna, 2019, Int J Obes Suppl, V9, P10, DOI 10.1038/s41367-019-0011-7
   O'Neill LAJ, 2013, NATURE, V493, P346, DOI 10.1038/nature11862
   Ozcan M, 2019, FUND CLIN PHARMACOL, V33, P170, DOI 10.1111/fcp.12413
   Park YS, 2020, INTEST RES, V18, P325, DOI 10.5217/ir.2019.00093
   Promsan S, 2022, FOOD CHEM TOXICOL, V165, DOI 10.1016/j.fct.2022.113190
   Pu RY, 2020, THER ADV ENDOCRINOL, V11, DOI 10.1177/2042018820926000
   Rajan SS, 2016, IMMUNOLOGY, V149, P353, DOI 10.1111/imm.12653
   Vinolo MAR, 2012, AM J PHYSIOL-ENDOC M, V303, pE272, DOI 10.1152/ajpendo.00053.2012
   Rebai R, 2021, BIOMED PHARMACOTHER, V135, DOI 10.1016/j.biopha.2021.111246
   Reiter RJ, 2014, FERTIL STERIL, V102, P321, DOI 10.1016/j.fertnstert.2014.06.014
   Ren WK, 2018, J PINEAL RES, V64, DOI 10.1111/jpi.12448
   Rodriguez C, 2004, J PINEAL RES, V36, P1, DOI 10.1046/j.1600-079X.2003.00092.x
   Rodriguez-Nogales A, 2017, MOL NUTR FOOD RES, V61, DOI 10.1002/mnfr.201700144
   Rovella V, 2021, NUTRIENTS, V13, DOI 10.3390/nu13020613
   Ruderman NB, 2013, J CLIN INVEST, V123, P2764, DOI 10.1172/JCI67227
   Salminen A, 2011, J MOL MED, V89, P667, DOI 10.1007/s00109-011-0748-0
   Schultze SM, 2012, EXPERT REV MOL MED, V14, DOI 10.1017/S1462399411002109
   Sharifnia T, 2015, AM J PHYSIOL-GASTR L, V309, pG270, DOI 10.1152/ajpgi.00304.2014
   Sharma M., 2016, DIABETES METABOLIC S, P33
   Shen J, 2013, MOL ASPECTS MED, V34, P39, DOI 10.1016/j.mam.2012.11.001
   Su JR, 2016, HORM METAB RES, V48, P92, DOI 10.1055/s-0035-1569287
   Tan DX, 2015, MOLECULES, V20, P18886, DOI 10.3390/molecules201018886
   Targher G, 2016, J HEPATOL, V65, P589, DOI 10.1016/j.jhep.2016.05.013
   Teixeira TFS, 2012, CLIN NUTR, V31, P735, DOI 10.1016/j.clnu.2012.02.009
   Vallianou N, 2022, BIOMOLECULES, V12, DOI 10.3390/biom12010056
   Wang L, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0218490
   Woo SL, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0091111
   World Health Organization, 2019, OB OV
   Wu SJ, 2021, J NUTR BIOCHEM, V91, DOI 10.1016/j.jnutbio.2021.108602
   Xu PQ, 2019, BIOMED PHARMACOTHER, V120, DOI 10.1016/j.biopha.2019.109458
   Xu PF, 2017, J PINEAL RES, V62, DOI 10.1111/jpi.12399
   Yadav A, 2013, CLIN CHIM ACTA, V417, P80, DOI 10.1016/j.cca.2012.12.007
   Yang XY, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.749125
   Zabielski P, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-25397-6
   Zhang HM, 2014, J PINEAL RES, V57, P131, DOI 10.1111/jpi.12162
   Zhang Q, 2020, DIABET METAB SYND OB, V13, P5003, DOI 10.2147/DMSO.S286430
NR 85
TC 2
Z9 2
U1 14
U2 24
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD SEP
PY 2022
VL 153
AR 113445
DI 10.1016/j.biopha.2022.113445
EA JUL 2022
PG 16
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 3S0UT
UT WOS:000839319900001
PM 36076560
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Tseng, CH
AF Tseng, Chin-Hsiao
TI The Relationship between Diabetes Mellitus and Gastric Cancer and the
   Potential Benefits of Metformin: An Extensive Review of the Literature
SO BIOMOLECULES
LA English
DT Review
DE diabetes mellitus; gastric cancer; Helicobacter pylori; insulin
   resistance; metformin; microbiota
ID POPULATION-BASED COHORT; HELICOBACTER-PYLORI INFECTION; EN-Y
   RECONSTRUCTION; RISK-FACTORS; TAIWANESE PATIENTS; POSTOPERATIVE
   COMPLICATIONS; GASTROINTESTINAL CANCERS; GLUCOSE-METABOLISM; ESOPHAGEAL
   CANCER; STOMACH-CANCER
AB The objective of this review is to summarize the findings of published research that investigated the relationship between diabetes mellitus and gastric cancer (GCa) and the potential benefits of metformin on GCa. Related literature has been extensively reviewed, and findings from studies investigating the relationship between diabetes mellitus and GCa suggest that hyperglycemia, hyperinsulinemia and insulin resistance are closely related to the development of GCa. Although not supported by all, most observational studies suggest an increased risk of GCa in patients with type 2 diabetes mellitus, especially in women and in Asian populations. Incidence of second primary malignancy diagnosed after GCa is significantly higher in diabetes patients. Diabetes patients with GCa may have more complications after gastrectomy or chemotherapy and they may have a poorer prognosis than patients with GCa but without diabetes mellitus. However, glycemic control may improve in the diabetes patients with GCa after receiving gastrectomy, especially after procedures that bypass the duodenum and proximal jejunum, such as Roux-en-Y gastric bypass or Billroth II reconstruction. The potential links between diabetes mellitus and GCa may involve the interactions with shared risk factors (e.g., obesity, hyperglycemia, hyperinsulinemia, insulin resistance, high salt intake, smoking, etc.), Helicobacter pylori (HP) infection, medications (e.g., insulin, metformin, statins, aspirin, proton pump inhibitors, antibiotics, etc.) and comorbidities (e.g., hypertension, dyslipidemia, vascular complications, heart failure, renal failure, etc.). With regards to the potential benefits of metformin on GCa, results of most observational studies suggest a reduced risk of GCa associated with metformin use in patients with T2DM, which can be supported by evidence derived from many in vitro and animal studies. Metformin use may also reduce the risk of HP infection, an important risk factor of GCa. In patients with GCa, metformin users may have improved survival and reduced recurrence. More studies are required to clarify the pathological subtypes/anatomical sites of GCa associated with type 2 diabetes mellitus or prevented by metformin, to confirm whether GCa risk can also be increased in patients with type 1 diabetes mellitus and to explore the possible role of gastric microbiota in the development of GCa.
C1 [Tseng, Chin-Hsiao] Natl Taiwan Univ, Dept Internal Med, Coll Med, Taipei 10051, Taiwan.
   [Tseng, Chin-Hsiao] Natl Taiwan Univ Hosp, Dept Internal Med, Div Endocrinol & Metab, Taipei 10051, Taiwan.
   [Tseng, Chin-Hsiao] Natl Hlth Res Inst, Div Environm Hlth & Occupat Med, Zhunan 350, Taiwan.
   [Tseng, Chin-Hsiao] Natl Taiwan Univ Hosp, Dept Internal Med, 7 Chung Shan South Rd, Taipei 100, Taiwan.
C3 National Taiwan University; National Taiwan University; National Taiwan
   University Hospital; National Health Research Institutes - Taiwan;
   National Taiwan University; National Taiwan University Hospital
RP Tseng, CH (通讯作者)，Natl Taiwan Univ, Dept Internal Med, Coll Med, Taipei 10051, Taiwan.; Tseng, CH (通讯作者)，Natl Taiwan Univ Hosp, Dept Internal Med, Div Endocrinol & Metab, Taipei 10051, Taiwan.; Tseng, CH (通讯作者)，Natl Hlth Res Inst, Div Environm Hlth & Occupat Med, Zhunan 350, Taiwan.; Tseng, CH (通讯作者)，Natl Taiwan Univ Hosp, Dept Internal Med, 7 Chung Shan South Rd, Taipei 100, Taiwan.
EM ccktsh@ms6.hinet.net
OI TSENG, CHIN-HSIAO/0000-0001-9545-7123
FU Ministry of Science and Technology [MOST 107-2221-E-002-129-MY3]; Yee
   Fong Charity Foundation
FX Related research was funded by the Ministry of Science and Technology
   (MOST 107-2221-E-002-129-MY3) and the Yee Fong Charity Foundation.
CR Al Assal K, 2020, NUTRIENTS, V12, DOI 10.3390/nu12020278
   Ammori JB, 2018, J SURG RES, V224, P176, DOI 10.1016/j.jss.2017.12.004
   Ashrafian H, 2011, OBES REV, V12, pe257, DOI 10.1111/j.1467-789X.2010.00802.x
   Bach LA, 2013, CLIN SCI, V124, P215, DOI 10.1042/CS20120343
   Bae WJ, 2019, J EXP CLIN CANC RES, V38, DOI 10.1186/s13046-019-1469-4
   Baglia ML, 2019, CANCER RES TREAT, V51, P538, DOI 10.4143/crt.2017.591
   Best LG, 2015, CANCER CAUSE CONTROL, V26, P1551, DOI 10.1007/s10552-015-0648-7
   Bi YF, 2014, J DIABETES, V6, P147, DOI 10.1111/1753-0407.12108
   Bosetti C, 2012, NUTR CANCER, V64, P643, DOI 10.1080/01635581.2012.676141
   Cao TTB, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.573891
   Carstensen B, 2012, DIABETOLOGIA, V55, P948, DOI 10.1007/s00125-011-2381-4
   Chang CH, 2012, J CLIN ENDOCR METAB, V97, pE1170, DOI 10.1210/jc.2012-1162
   Chang HR, 2016, GUT, V65, P19, DOI 10.1136/gutjnl-2014-307918
   Chang JS, 2019, CANCER EPIDEM BIOMAR, V28, P1694, DOI 10.1158/1055-9965.EPI-19-0355
   Chen F, 2018, J MED CHEM, V61, P7330, DOI 10.1021/acs.jmedchem.8b00906
   Chen GX, 2019, ONCOL REP, V41, P405, DOI 10.3892/or.2018.6783
   Chen GX, 2015, AM J CANCER RES, V5, P1423
   Chen SC, 2016, GASTRIC CANCER, V19, P490, DOI 10.1007/s10120-015-0482-3
   Chen XH, 2020, CHINESE J CANCER RES, V32, P631, DOI 10.21147/j.issn.1000-9604.2020.05.08
   Chen YC, 2020, AM J TRANSL RES, V12, P4885
   Chen Y, 2017, DIABETOLOGIA, V60, P1022, DOI 10.1007/s00125-017-4229-z
   Chen YL, 2013, GASTRIC CANCER, V16, P389, DOI 10.1007/s10120-012-0197-7
   Cheung KS, 2020, CANCER EPIDEM BIOMAR, V29, P493, DOI 10.1158/1055-9965.EPI-19-1044
   Cheung KS, 2019, DIABETES CARE, V42, P1769, DOI 10.2337/dc19-0437
   Cheung KS, 2019, THER ADV GASTROENTER, V12, DOI 10.1177/1756284819834511
   Cheung KS, 2019, JNCI-J NATL CANCER I, V111, P484, DOI 10.1093/jnci/djy144
   Cheung KS, 2018, WORLD J GASTRO ONCOL, V10, P115, DOI 10.4251/wjgo.v10.i5.115
   Chia NY, 2015, GUT, V64, P707, DOI 10.1136/gutjnl-2013-306596
   Chiu CC, 2013, INTERNAL MED, V52, P939, DOI 10.2169/internalmedicine.52.8276
   Cho MH, 2021, CANCER PREV RES, V14, P95, DOI 10.1158/1940-6207.CAPR-20-0123
   Chodick G, 2010, CANCER CAUSE CONTROL, V21, P879, DOI 10.1007/s10552-010-9515-8
   Choi SI, 2019, MOL CANCER RES, V17, P2169, DOI 10.1158/1541-7786.MCR-19-0181
   Chuck KW, 2017, EPIDEMIOL HEALTH, V39, DOI 10.4178/epih.e2017036
   Chung WS, 2020, CANCERS, V12, DOI 10.3390/cancers12082013
   Courtois S, 2019, GASTRIC CANCER, V22, P653, DOI 10.1007/s10120-019-00952-w
   Courtois S, 2017, EUR J CANCER, V84, P193, DOI 10.1016/j.ejca.2017.07.020
   Dankner R, 2016, AM J EPIDEMIOL, V183, P1098, DOI 10.1093/aje/kwv290
   de Jong RG, 2017, CANCER PREV RES, V10, P290, DOI 10.1158/1940-6207.CAPR-16-0277
   de Jong RGPJ, 2018, CANCER EPIDEMIOL, V54, P104, DOI 10.1016/j.canep.2018.04.008
   Dixon JL, 2016, DIS ESOPHAGUS, V29, P747, DOI 10.1111/dote.12402
   Djiogue S, 2013, ENDOCR-RELAT CANCER, V20, pR1, DOI 10.1530/ERC-12-0324
   Dulskas A, 2020, J CLIN MED, V9, DOI 10.3390/jcm9020435
   Dulskas A, 2019, AGING-US, V11, P7197, DOI 10.18632/aging.102245
   Engstrand L, 2020, DIGEST DIS SCI, V65, P865, DOI 10.1007/s10620-020-06101-z
   Fang HJ, 2018, BMC CANCER, V18, DOI 10.1186/s12885-018-4351-4
   Fang WL, 2015, MEDICINE, V94, DOI 10.1097/MD.0000000000002163
   Fang WZ, 2014, MED ONCOL, V31, DOI 10.1007/s12032-014-0015-7
   Fatehi-Agdam M, 2021, DRUG RES, V71, P17, DOI 10.1055/a-1248-9008
   Ferlay J, 2019, INT J CANCER, V144, P1941, DOI 10.1002/ijc.31937
   Fiorillo C, 2020, SURGERY, V167, P815, DOI 10.1016/j.surg.2019.11.006
   Fiorillo C, 2017, GASTRIC CANCER, V20, P536, DOI 10.1007/s10120-016-0621-5
   Franciosi M, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0071583
   Gallagher EJ, 2020, NAT REV CANCER, V20, P629, DOI 10.1038/s41568-020-0295-5
   Ge ZM, 2011, EUR J GASTROEN HEPAT, V23, P1127, DOI 10.1097/MEG.0b013e32834b8d73
   Gong Y, 2012, WORLD J GASTROENTERO, V18, P563, DOI 10.3748/wjg.v18.i6.563
   Guner A, 2017, ONCOTARGET, V8, P104605, DOI 10.18632/oncotarget.22262
   Hamakawa T, 2016, SURG TODAY, V46, P224, DOI 10.1007/s00595-015-1175-6
   Han G, 2015, CANCER BIOL THER, V16, P77, DOI 10.4161/15384047.2014.987021
   Hayashi M, 2020, BMC SURG, V20, DOI 10.1186/s12893-020-00813-9
   Hayashi SY, 2013, SURG ENDOSC, V27, P2829, DOI 10.1007/s00464-013-2829-3
   He L, 2020, TRENDS PHARMACOL SCI, V41, P868, DOI 10.1016/j.tips.2020.09.001
   He L, 2015, CELL METAB, V21, P159, DOI 10.1016/j.cmet.2015.01.003
   He XN, 2018, CURR MED RES OPIN, V34, P1089, DOI 10.1080/03007995.2017.1421527
   Heckl SM, 2019, GASTRIC CANCER, V22, P1130, DOI 10.1007/s10120-019-00964-6
   Hidaka A, 2015, INT J CANCER, V136, P1402, DOI 10.1002/ijc.29098
   Hirakawa Y, 2012, AM J EPIDEMIOL, V176, P856, DOI 10.1093/aje/kws178
   Ho TW, 2016, SURG OBES RELAT DIS, V12, P635, DOI 10.1016/j.soard.2015.11.024
   Hong SH, 2020, CLIN TRANSL GASTROEN, V11, DOI 10.14309/ctg.0000000000000221
   Horikawa C, 2014, DIABETES RES CLIN PR, V106, P81, DOI 10.1016/j.diabres.2014.07.009
   Huang DQ, 2016, ONCOTARGET, V7, P6188, DOI 10.18632/oncotarget.6748
   Huang Y, 2014, DIABETOLOGIA, V57, P2261, DOI 10.1007/s00125-014-3361-2
   Idilbi NM, 2013, ISR MED ASSOC J, V15, P342
   Iki M, 2019, BONE, V127, P250, DOI 10.1016/j.bone.2019.06.014
   Inoue M, 2006, ARCH INTERN MED, V166, P1871, DOI 10.1001/archinte.166.17.1871
   Inzucchi SE, 2012, DIABETOLOGIA, V55, P1577, DOI 10.1007/s00125-012-2534-0
   Janssen JAMJL, 2014, FRONT ENDOCRINOL, V5, DOI 10.3389/fendo.2014.00079
   Jee SH, 2005, JAMA-J AM MED ASSOC, V293, P194, DOI 10.1001/jama.293.2.194
   Jiang XJ, 2012, INT J CANCER, V131, P1417, DOI 10.1002/ijc.27390
   Joo Moon Kyung, 2018, Dig Dis, V36, P1, DOI 10.1159/000480149
   Jun Jae Kwan, 2006, J Prev Med Public Health, V39, P493
   Jun JH, 2016, INT J SURG, V28, P162, DOI 10.1016/j.ijsu.2016.02.084
   Jun KH, 2015, ONCOL REP, V34, P2047, DOI 10.3892/or.2015.4191
   Jun KH, 2015, GASTROENT RES PRACT, V2015, DOI 10.1155/2015/827864
   Kang KC, 2012, J KOREAN SURG SOC, V82, P347, DOI 10.4174/jkss.2012.82.6.347
   Karlin NJ, 2019, FUTUR SCI OA, V5, DOI 10.2144/fsoa-2019-0038
   Karlstad O, 2013, CURR DRUG SAF, V8, P333, DOI 10.2174/15680266113136660067
   Kashihara H, 2018, ANTICANCER RES, V38, P4901, DOI 10.21873/anticanres.12805
   Kato K, 2012, MOL CANCER THER, V11, P549, DOI 10.1158/1535-7163.MCT-11-0594
   Khan Mmh, 2006, Asian Pac J Cancer Prev, V7, P253
   Kim JW, 2012, WORLD J GASTROENTERO, V18, P49, DOI 10.3748/wjg.v18.i1.49
   Kim J, 2020, GASTRIC CANCER, V23, P1075, DOI 10.1007/s10120-020-01085-1
   Kim SK, 2020, KOREAN J INTERN MED, V35, P641, DOI 10.3904/kjim.2017.402
   Kim TJ, 2016, J GASTROEN HEPATOL, V31, P1705, DOI 10.1111/jgh.13329
   Kim WS, 2013, J KOREAN SURG SOC, V84, P88, DOI 10.4174/jkss.2013.84.2.88
   Kim WJ, 2020, CHINESE J CANCER RES, V32, P252, DOI 10.21147/j.issn.1000-9604.2020.02.12
   Kim YM, 2019, FRONT ONCOL, V9, DOI 10.3389/fonc.2019.01249
   Kim YI, 2016, CANCER RES TREAT, V48, P798, DOI 10.4143/crt.2015.117
   Ku CR, 2017, DIABETES, V66, P385, DOI 10.2337/db16-1000
   Kuriki K, 2007, EUR J CANCER PREV, V16, P83, DOI 10.1097/01.cej.0000228404.37858.40
   Kwon HJ, 2019, GUT LIVER, V13, P154, DOI 10.5009/gnl17556
   Kwon Y, 2015, SURG OBES RELAT DIS, V11, P1386, DOI 10.1016/j.soard.2015.01.001
   Kwon Y, 2014, SURG OBES RELAT DIS, V10, P235, DOI 10.1016/j.soard.2013.09.013
   Lacroix O, 2018, CANCER EPIDEMIOL, V53, P149, DOI 10.1016/j.canep.2018.02.001
   Lai GY, 2013, J CLIN ENDOCR METAB, V98, pE497, DOI 10.1210/jc.2012-3335
   Lee CK, 2016, ANN SURG, V263, P96, DOI 10.1097/SLA.0000000000001086
   Lee H, 2020, NUTRIENTS, V12, DOI 10.3390/nu12061750
   Lee J, 2012, BMC CANCER, V12, DOI 10.1186/1471-2407-12-596
   Lee MS, 2011, BMC CANCER, V11, DOI 10.1186/1471-2407-11-20
   Lee W, 2012, OBES SURG, V22, P1238, DOI 10.1007/s11695-011-0580-1
   Lee YC, 2016, GASTROENTEROLOGY, V150, P1113, DOI 10.1053/j.gastro.2016.01.028
   Lesan Vahid, 2014, Int J Hematol Oncol Stem Cell Res, V8, P12
   Li FX, 2018, FRONT ONCOL, V8, DOI 10.3389/fonc.2018.00326
   Li PW, 2019, J CELL PHYSIOL, V234, P4515, DOI 10.1002/jcp.27269
   Li PW, 2018, ONCOL LETT, V15, P1191, DOI 10.3892/ol.2017.7370
   Li WL, 2018, ONCOGENE, V37, P6383, DOI 10.1038/s41388-018-0402-1
   Li WJ, 2019, J EXP CLIN CANC RES, V38, DOI 10.1186/s13046-019-1309-6
   Li Y, 2017, J INVEST SURG, V30, P394, DOI 10.1080/08941939.2016.1265617
   Li ZB, 2019, DIABETOL METAB SYNDR, V11, DOI 10.1186/s13098-019-0478-y
   Lin SW, 2011, CANCER EPIDEM BIOMAR, V20, P954, DOI 10.1158/1055-9965.EPI-10-1244
   Lin XH, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0206930
   Lin XT, 2015, J SURG RES, V196, P294, DOI 10.1016/j.jss.2015.03.017
   Liu S, 2020, ONCOTARGETS THER, V13, P4445, DOI 10.2147/OTT.S242298
   Lu CC, 2019, INT J ONCOL, V54, P1271, DOI 10.3892/ijo.2019.4704
   Luo JH, 2013, CANCER CAUSE CONTROL, V24, P577, DOI 10.1007/s10552-012-9996-8
   Maniar K, 2017, PHARMACOL RES, V117, P103, DOI 10.1016/j.phrs.2016.12.003
   Mariani M, 2021, EUR J CANCER PREV, V30, P239, DOI 10.1097/CEJ.0000000000000618
   Miao ZF, 2020, CELL STEM CELL, V26, P910, DOI 10.1016/j.stem.2020.03.006
   Miao ZF, 2017, ONCOTARGET, V8, P44881, DOI 10.18632/oncotarget.16487
   Miki Y, 2016, SURG TODAY, V46, P552, DOI 10.1007/s00595-015-1201-8
   Mohammadzadeh F, 2015, IRISH J MED SCI, V184, P277, DOI 10.1007/s11845-014-1100-9
   Murff HJ, 2018, CANCER CAUSE CONTROL, V29, P823, DOI 10.1007/s10552-018-1058-4
   Nakajima K, 2017, CLIN BIOCHEM, V50, P97, DOI 10.1016/j.clinbiochem.2016.10.005
   Nakamura K, 2013, CANCER SCI, V104, P1362, DOI 10.1111/cas.12235
   Nath M, 2020, EUR J PHARMACOL, V884, DOI 10.1016/j.ejphar.2020.173349
   Ohkuma T, 2018, DIABETOLOGIA, V61, P2140, DOI 10.1007/s00125-018-4664-5
   Paik KH, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000003157
   Papamargaritis D, 2021, NUTRIENTS, V13, DOI 10.3390/nu13030762
   Park YM, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000005351
   Peng D, 2020, DIABETES THER, V11, P2863, DOI 10.1007/s13300-020-00934-7
   Qi JY, 2019, J DIABETES, V11, P878, DOI 10.1111/1753-0407.12926
   Rawla P, 2019, GASTROENTEROL REV, V14, P26, DOI 10.5114/pg.2018.80001
   Romon I, 2014, DIABETIC MED, V31, P946, DOI 10.1111/dme.12435
   Saarela K, 2019, EUR J EPIDEMIOL, V34, P259, DOI 10.1007/s10654-018-0438-0
   Safe S, 2018, CANCER PREV RES, V11, P371, DOI 10.1158/1940-6207.CAPR-17-0407
   Saisho Y, 2015, ENDOCR METAB IMMUNE, V15, P196, DOI 10.2174/1871530315666150316124019
   Scalia P, 2020, BIOMOLECULES, V10, DOI 10.3390/biom10121617
   Sciacca L, 2018, NUTR METAB CARDIOVAS, V28, P436, DOI 10.1016/j.numecd.2018.02.010
   Sciacca Laura, 2012, Front Endocrinol (Lausanne), V3, P21, DOI 10.3389/fendo.2012.00021
   Sekikawa A, 2014, EUR J CANCER, V50, P2065, DOI 10.1016/j.ejca.2014.05.020
   Sekino N, 2018, ANTICANCER RES, V38, P6263, DOI 10.21873/anticanres.12982
   Seo GH, 2018, MEDICINE, V97, DOI 10.1097/MD.0000000000010532
   Seo HS, 2019, AM J CLIN ONCOL-CANC, V42, P909, DOI 10.1097/COC.0000000000000627
   Shen C, 2014, PREV MED, V64, P20, DOI 10.1016/j.ypmed.2014.03.021
   Shen ZY, 2015, HEPATO-GASTROENTEROL, V62, P245, DOI 10.5754/hge14857
   Sheng LL, 2020, J GASTROINTEST ONCOL, V11, P999, DOI 10.21037/jgo-20-375
   Sheu SM, 2014, J BIOMED SCI, V21, DOI 10.1186/s12929-014-0096-9
   Shimoyama S, 2013, WORLD J GASTROENTERO, V19, P6902, DOI 10.3748/wjg.v19.i40.6902
   Shuai Y, 2020, CLIN TRANSL ONCOL, V22, P1580, DOI 10.1007/s12094-020-02304-y
   Sieri S, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-09498-2
   Song M, 2019, CANCER RES TREAT, V51, P841, DOI 10.4143/crt.2019.151
   Song Z, 2017, MOL MED REP, V15, P1909, DOI 10.3892/mmr.2017.6205
   Stewart OA, 2020, GUT MICROBES, V11, P1220, DOI 10.1080/19490976.2020.1762520
   Sung H, 2021, CA-CANCER J CLIN, V71, P209, DOI 10.3322/caac.21660
   Takeuchi D, 2014, INT J SURG, V12, P587, DOI 10.1016/j.ijsu.2014.04.012
   Thrift AP, 2020, CLIN GASTROENTEROL H, V18, P534, DOI 10.1016/j.cgh.2019.07.045
   Tian T, 2012, EXP CLIN ENDOCR DIAB, V120, P217, DOI 10.1055/s-0031-1297969
   Tsai MS, 2015, MEDICINE, V94, DOI 10.1097/MD.0000000000001467
   Tseng CH, 2019, DIABETES METAB, V45, P184, DOI 10.1016/j.diabet.2018.05.001
   Tseng CH, 2017, DIABETES METAB, V43, P438, DOI 10.1016/j.diabet.2017.03.004
   Tseng CH, 2019, DIABETES METAB, V45, P458, DOI 10.1016/j.diabet.2019.05.002
   Tseng CH, 2004, DIABETES CARE, V27, P1605, DOI 10.2337/diacare.27.7.1605
   Tseng CH, 2021, FRONT MED-LAUSANNE, V7, DOI 10.3389/fmed.2020.592901
   Tseng CH, 2021, FRONT PHARMACOL, V11, DOI 10.3389/fphar.2020.578831
   Tseng CH, 2021, EUR J ENDOCRINOL, V184, P299, DOI 10.1530/EJE-20-0507
   Tseng CH, 2020, FRONT ONCOL, V10, DOI 10.3389/fonc.2020.587666
   Tseng CH, 2021, J CROHNS COLITIS, V15, P64, DOI 10.1093/ecco-jcc/jjaa136
   Tseng CH, 2020, AGING DIS, V11, P658, DOI 10.14336/AD.2019.0621
   Tseng CH, 2019, THER ADV ENDOCRINOL, V10, DOI 10.1177/2042018819895159
   Tseng CH, 2019, J AM HEART ASSOC, V8, DOI 10.1161/JAHA.118.011640
   Tseng CH, 2020, DIABETES-METAB RES, V36, DOI 10.1002/dmrr.3206
   Tseng CH, 2019, EUR J ENDOCRINOL, V180, P365, DOI 10.1530/EJE-19-0133
   Tseng CH, 2019, AGING DIS, V10, P37, DOI 10.14336/AD.2017.1202
   Tseng CH, 2018, PANCREAS, V47, pE57, DOI 10.1097/MPA.0000000000001130
   Tseng CH, 2018, J AM HEART ASSOC, V7, DOI 10.1161/JAHA.118.008860
   Tseng CH, 2018, LIVER INT, V38, P2018, DOI 10.1111/liv.13872
   Tseng CH, 2018, METABOLISM, V85, P223, DOI 10.1016/j.metabol.2018.04.009
   Tseng CH, 2018, J AM ACAD DERMATOL, V78, P694, DOI 10.1016/j.jaad.2017.12.016
   Tseng CH, 2018, DIABETES CARE, V41, pE42, DOI 10.2337/dc17-2551
   Tseng CH, 2017, ONCOTARGET, V8, P41132, DOI 10.18632/oncotarget.17066
   Tseng CH, 2017, ONCOTARGET, V8, P18802, DOI 10.18632/oncotarget.13390
   Tseng CH, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0147916
   Tseng CH, 2016, ONCOTARGET, V7, P59548, DOI 10.18632/oncotarget.10934
   Tseng CH, 2016, AGING-US, V8, P1636, DOI 10.18632/aging.101019
   Tseng CH, 2016, ONCOTARGET, V7, P2000, DOI 10.18632/oncotarget.6626
   Tseng CH, 2016, EUR J CANCER, V52, P19, DOI 10.1016/j.ejca.2015.09.027
   Tseng CH, 2015, DIABETES-METAB RES, V31, P619, DOI 10.1002/dmrr.2649
   Tseng CH, 2015, GYNECOL ONCOL, V138, P147, DOI 10.1016/j.ygyno.2015.03.059
   Tseng CH, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0109852
   Tseng CH, 2014, EUR J CANCER, V50, P2831, DOI 10.1016/j.ejca.2014.08.007
   Tseng CH, 2014, BREAST CANCER RES TR, V145, P785, DOI 10.1007/s10549-014-2985-8
   Tseng CH, 2014, ACTA DIABETOL, V51, P295, DOI 10.1007/s00592-014-0562-6
   Tseng CH, 2014, WORLD J GASTROENTERO, V20, P1701, DOI 10.3748/wjg.v20.i7.1701
   Tseng CH, 2013, J CLIN GASTROENTEROL, V47, pE60, DOI 10.1097/MCG.0b013e31827245eb
   Tseng CH, 2012, EUR J ENDOCRINOL, V167, P409, DOI 10.1530/EJE-12-0369
   Tseng CH, 2012, BMC GASTROENTEROL, V12, DOI 10.1186/1471-230X-12-46
   Tseng CH, 2011, GUT, V60, P774, DOI 10.1136/gut.2010.226522
   Turner RC, 1998, LANCET, V352, P854, DOI 10.1016/s0140-6736(98)07037-8
   Uchida M, 2019, ANN PHARMACOTHER, V53, P1200, DOI 10.1177/1060028019865870
   Ugwueze CV, 2020, ANAL CELL PATHOL, V2020, DOI 10.1155/2020/7180923
   Valaee S, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0174486
   Valent F, 2015, J DIABETES COMPLICAT, V29, P1056, DOI 10.1016/j.jdiacomp.2015.07.017
   Wang JB, 2017, SURG ENDOSC, V31, P2651, DOI 10.1007/s00464-016-5279-x
   Wang M, 2015, SCI REP-UK, V5, DOI 10.1038/srep11503
   Wang SL, 2016, ANN SURG ONCOL, V23, P556, DOI 10.1245/s10434-015-4887-3
   Wei ZW, 2014, DIGEST DIS SCI, V59, P1017, DOI 10.1007/s10620-013-2965-6
   Wierzba W, 2019, ARCH MED SCI, V15, P330, DOI 10.5114/aoms.2017.68409
   Wu WW, 2019, MEDICINE, V98, DOI 10.1097/MD.0000000000014639
   Wu XD, 2013, EUR J CLIN PHARMACOL, V69, P1855, DOI 10.1007/s00228-013-1547-z
   Wu XC, 2017, PAK J PHARM SCI, V30, P1833
   Xiao Hua, 2014, Zhonghua Yi Xue Za Zhi, V94, P3310
   Xiao Hua, 2013, Zhonghua Yi Xue Za Zhi, V93, P3211
   Xu HL, 2015, CANCER SCI, V106, P294, DOI 10.1111/cas.12597
   Xu WT, 2016, J EXP CLIN CANC RES, V35, DOI 10.1186/s13046-015-0276-9
   Yamagata H, 2005, DIABETES CARE, V28, P789, DOI 10.2337/diacare.28.4.789
   Yamaguchi K, 2018, CANCER CHEMOTH PHARM, V82, P625, DOI 10.1007/s00280-018-3652-2
   Yang HJ, 2020, GASTRIC CANCER, V23, P382, DOI 10.1007/s10120-019-01033-8
   Yazici O, 2016, WORLD J GASTROENTERO, V22, P471, DOI 10.3748/wjg.v22.i2.471
   Yi HK, 2001, EUR J CANCER, V37, P2257, DOI 10.1016/S0959-8049(01)00269-6
   Yoon JM, 2013, WORLD J GASTROENTERO, V19, P936, DOI 10.3748/wjg.v19.i6.936
   Yu GZ, 2015, ONCOTARGET, V6, P12748, DOI 10.18632/oncotarget.3327
   Yuan LW, 2016, WORLD J GASTROENTERO, V22, P2046, DOI 10.3748/wjg.v22.i6.2046
   Zanders MMJ, 2018, DIABETES METAB, V44, P22, DOI 10.1016/j.diabet.2017.08.004
   Zhang HH, 2016, CANCER CHEMOTH PHARM, V78, P13, DOI 10.1007/s00280-016-3037-3
   Zhang J, 2020, CANCER MANAG RES, V12, P8545, DOI 10.2147/CMAR.S264032
   Zhang K, 2021, PRIM CARE DIABETES, V15, P52, DOI 10.1016/j.pcd.2020.06.001
   Zhang Q, 2020, DIABET METAB SYND OB, V13, P5003, DOI 10.2147/DMSO.S286430
   Zhang XC, 2012, ASIAN PAC J CANCER P, V13, P97, DOI 10.7314/APJCP.2012.13.1.097
   Zhang XJ, 2013, ARCH MED RES, V44, P437, DOI 10.1016/j.arcmed.2013.07.004
   Zhao B, 2020, LIFE SCI, V254, DOI 10.1016/j.lfs.2020.117717
   Zhao W, 2015, MOL MED REP, V12, P843, DOI 10.3892/mmr.2015.3522
   Zheng JJ, 2019, BRIT J CANCER, V121, P877, DOI 10.1038/s41416-019-0598-z
   Zheng JJ, 2019, BRIT J CANCER, V120, P1147, DOI 10.1038/s41416-019-0470-1
   Zhou XL, 2017, ONCOTARGET, V8, P55622, DOI 10.18632/oncotarget.16973
   Zhou YC, 2015, DIGEST DIS SCI, V60, P2338, DOI 10.1007/s10620-015-3625-9
   Zhuang S, 2017, EXP CLIN ENDOCR DIAB, V125, P392, DOI 10.1055/s-0043-100118
   Zuo XL, 2018, THER CLIN RISK MANAG, V14, P965, DOI 10.2147/TCRM.S164929
NR 246
TC 12
Z9 12
U1 5
U2 18
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-273X
J9 BIOMOLECULES
JI Biomolecules
PD JUL
PY 2021
VL 11
IS 7
AR 1022
DI 10.3390/biom11071022
PG 25
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA TN9NF
UT WOS:000676551800001
PM 34356646
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Mueller, NT
   Differding, MK
   Zhang, MY
   Maruthur, NM
   Juraschek, SP
   Miller, ER
   Appel, LJ
   Yeh, HC
AF Mueller, Noel T.
   Differding, Moira K.
   Zhang, Mingyu
   Maruthur, Nisa M.
   Juraschek, Stephen P.
   Miller, Edgar R., III
   Appel, Lawrence J.
   Yeh, Hsin-Chieh
TI Metformin Affects Gut Microbiome Composition and Function and
   Circulating Short-Chain Fatty Acids: A Randomized Trial
SO DIABETES CARE
LA English
DT Article
ID INSULIN
AB OBJECTIVE To determine the longer-term effects of metformin treatment and behavioral weight loss on gut microbiota and short-chain fatty acids (SCFAs). RESEARCH DESIGN AND METHODS We conducted a 3-parallel-arm, randomized trial. We enrolled overweight/obese adults who had been treated for solid tumors but had no ongoing cancer treatment and randomized them (n = 121) to either 1) metformin (up to 2,000 mg), 2) coach-directed behavioral weight loss, or 3) self-directed care (control) for 12 months. We collected stool and serum at baseline (n = 114), 6 months (n = 109), and 12 months (n = 105). From stool, we extracted microbial DNA and conducted amplicon and metagenomic sequencing. We measured SCFAs and other biochemical parameters from fasting serum. RESULTS Of the 121 participants, 79% were female and 46% were Black, and the mean age was 60 years. Only metformin treatment significantly altered microbiota composition. Compared with control, metformin treatment increased amplicon sequence variants for Escherichia (confirmed as Escherichia coli by metagenomic sequencing) and Ruminococcus torques and decreased Intestinibacter bartlettii at both 6 and 12 months and decreased the genus Roseburia, including R. faecis and R. intestinalis, at 12 months. Effects were similar in comparison of the metformin group with the behavioral weight loss group. Metformin versus control also increased butyrate, acetate, and valerate at 6 months (but not at 12 months). Behavioral weight loss versus control did not significantly alter microbiota composition but did increase acetate at 6 months (but not at 12 months). Increases in acetate were associated with decreases in fasting insulin. Additional whole-genome metagenomic sequencing of a subset of the metformin group showed that metformin altered 62 metagenomic functional pathways, including an acetate-producing pathway and three pathways in glucose metabolism. CONCLUSIONS Metformin, but not behavioral weight loss, impacted gut microbiota composition at 6 months and 12 months. Both metformin and behavioral weight loss altered circulating SCFAs at 6 months, including increasing acetate, which correlated with lower fasting insulin. Future research is needed to elucidate whether the gut microboime mediates or modifies metformin's health effects.
C1 [Mueller, Noel T.; Differding, Moira K.; Zhang, Mingyu] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21218 USA.
   [Mueller, Noel T.; Differding, Moira K.; Zhang, Mingyu; Maruthur, Nisa M.; Miller, Edgar R., III; Appel, Lawrence J.; Yeh, Hsin-Chieh] Johns Hopkins Univ, Welch Ctr Prevent Epidemiol & Clin Res, Baltimore, MD 21218 USA.
   [Juraschek, Stephen P.] Beth Israel Deaconess Med Ctr, Div Gen Med & Primary Care, Boston, MA USA.
C3 Johns Hopkins University; Johns Hopkins Bloomberg School of Public
   Health; Johns Hopkins University; Harvard University; Beth Israel
   Deaconess Medical Center
RP Mueller, NT (通讯作者)，Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21218 USA.; Mueller, NT (通讯作者)，Johns Hopkins Univ, Welch Ctr Prevent Epidemiol & Clin Res, Baltimore, MD 21218 USA.
EM noeltmueller@jhu.edu
RI Zhang, mingyu/HGB-1069-2022; Appel, Larry/GLT-2608-2022; Zhang,
   Mingyu/O-4477-2018
OI Zhang, Mingyu/0000-0003-3628-0983; Mueller, Noel/0000-0002-7412-8352;
   Juraschek, Stephen/0000-0003-4168-2696
FU Maryland Cigarette Restitution Fund; National Heart, Lung, and Blood
   Institute of the National Institutes of Health [K01HL141589]; National
   Cancer Institute's Cancer Centers Support Grant [5P30CA006973]; American
   Heart Association [827990]; National Heart, Lung, and Blood Institute,
   NIH [T32 HL007024]
FX SPIRIT was funded by the Maryland Cigarette Restitution Fund. N.T.M. was
   supported by the National Heart, Lung, and Blood Institute of the
   National Institutes of Health (K01HL141589). H.-C.Y. was supported in
   part by the National Cancer Institute's Cancer Centers Support Grant to
   the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
   (5P30CA006973). M.Z. is supported by the American Heart Association
   (Award Number: 827990). M.K.D. is supported by the National Heart, Lung,
   and Blood Institute, NIH Grant Number T32 HL007024.
CR Appel LJ, 2011, NEW ENGL J MED, V365, P1959, DOI 10.1056/NEJMoa1108660
   Bailey CJ, 2008, DIABETOLOGIA, V51, P1552, DOI 10.1007/s00125-008-1053-5
   BAILEY CJ, 1992, DIABETES CARE, V15, P755, DOI 10.2337/diacare.15.6.755
   Bodenhofer U, 2015, BIOINFORMATICS, V31, P3997, DOI 10.1093/bioinformatics/btv494
   Bolger AM, 2014, BIOINFORMATICS, V30, P2114, DOI 10.1093/bioinformatics/btu170
   BONORA E, 1984, CURR MED RES OPIN, V9, P47, DOI 10.1185/03007998409109558
   Bouchoucha M, 2011, DIABETES METAB, V37, P90, DOI 10.1016/j.diabet.2010.11.002
   Bryrup T, 2019, DIABETOLOGIA, V62, P1024, DOI 10.1007/s00125-019-4848-7
   Buse JB, 2016, DIABETES CARE, V39, P198, DOI 10.2337/dc15-0488
   Cabreiro F, 2013, CELL, V153, P228, DOI 10.1016/j.cell.2013.02.035
   Callahan Ben J, 2016, F1000Res, V5, P1492
   Callahan BJ, 2016, NAT METHODS, V13, P581, DOI [10.1038/NMETH.3869, 10.1038/nmeth.3869]
   Choo JM, 2015, SCI REP-UK, V5, DOI 10.1038/srep16350
   Cole JR, 2014, NUCLEIC ACIDS RES, V42, pD633, DOI 10.1093/nar/gkt1244
   DANDONA P, 1983, DIABETES CARE, V6, P472, DOI 10.2337/diacare.6.5.472
   Dao MC, 2016, GUT, V65, P426, DOI 10.1136/gutjnl-2014-308778
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Elbere I, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0204317
   Fernandes AD, 2014, MICROBIOME, V2, DOI 10.1186/2049-2618-2-15
   Florez H, 2010, POSTGRAD MED, V122, P112, DOI 10.3810/pgm.2010.03.2128
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Fragiadakis GK, 2020, AM J CLIN NUTR, V111, P1127, DOI 10.1093/ajcn/nqaa046
   Hernandez MAG, 2019, NUTRIENTS, V11, DOI 10.3390/nu11081943
   Inzucchi SE, 2012, DIABETES CARE, V35, P1364, DOI 10.2337/dc12-0413
   Juraschek SP, 2018, CLIN TRIALS, V15, P130, DOI 10.1177/1740774517745829
   Kozich JJ, 2013, APPL ENVIRON MICROB, V79, P5112, DOI 10.1128/AEM.01043-13
   KRENTZ AJ, 1994, DRUG SAFETY, V11, P223, DOI 10.2165/00002018-199411040-00002
   Layden BT, 2012, DIABET METAB SYND OB, V5, P49, DOI 10.2147/DMSO.S29244
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Magoc T, 2011, BIOINFORMATICS, V27, P2957, DOI 10.1093/bioinformatics/btr507
   McMurdie PJ, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0061217
   Messori S, 2013, VET MICROBIOL, V162, P173, DOI 10.1016/j.vetmic.2012.09.001
   Mueller NT, 2020, AM J CLIN NUTR, V111, P545, DOI 10.1093/ajcn/nqz322
   Olgun A, 2017, MED HYPOTHESES, V106, P33, DOI [10.1016/j.mehy.2017.07.009, 10.1016]
   Rosario D, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.00775
   Schliep KP, 2011, BIOINFORMATICS, V27, P592, DOI 10.1093/bioinformatics/btq706
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Song YL, 2004, ANAEROBE, V10, P179, DOI 10.1016/j.anaerobe.2004.04.004
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Vila AV, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-019-14177-z
   Wong JMW, 2006, J CLIN GASTROENTEROL, V40, P235, DOI 10.1097/00004836-200603000-00015
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Yeh HC., 2021, J CLIN ENDOCR METAB
   Zhang X, 2015, SCI REP-UK, V5, DOI 10.1038/srep14405
   Zhernakova A, 2016, SCIENCE, V352, P565, DOI 10.1126/science.aad3369
NR 45
TC 35
Z9 36
U1 3
U2 18
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0149-5992
EI 1935-5548
J9 DIABETES CARE
JI Diabetes Care
PD JUL
PY 2021
VL 44
IS 7
BP 1462
EP 1471
DI 10.2337/dc20-2257
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA TR2PT
UT WOS:000678813200008
PM 34006565
OA Green Published, Bronze, Green Submitted
DA 2023-06-08
ER

PT J
AU Tseng, CH
AF Tseng, Chin-Hsiao
TI Metformin Reduces the Risk of Diverticula of Intestine in Taiwanese
   Patients with Type 2 Diabetes Mellitus
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE confounding by indication; diverticula of intestine; inverse probability
   of treatment weighting; metformin; propensity score
ID GUT MICROBIOME
AB Aim: To investigate the risk of diverticula of intestine associated with metformin use.
   Methods: This retrospective cohort study used the Taiwan's National Health Insurance database to enroll 307,548 ever users and 18,839 never users of metformin. The patients were followed up starting on January 1, 2006 and ending on a date up to December 31, 2011. To address confounding by indication, hazard ratios were derived from Cox regression based on the inverse probability of treatment weighting using propensity score.
   Results: During follow-up, newly diagnosed cases of diverticula were identified in 1,828 ever users (incidence rate: 125.59 per 100,000 person-years) and 223 never users (incidence rate: 268.17 per 100,000 person-years). Ever users had an approximately 54% lower risk, as shown by the overall hazard ratio of 0.464 (95% confidence interval 0.404-0.534). While patients categorized in each tertile of cumulative duration of metformin therapy were compared to never users, a dose-response pattern was observed with hazard ratios of 0.847 (0.730-0.983), 0.455 (0.391-0.531) and 0.216 (0.183-0.255) for the first (<27.37 months), second (27.37-59.70 months) and third (>59.70 months) tertiles, respectively. The findings were similar when the diagnosis of diverticula was restricted to the small intestine or to the colon. Subgroup analyses suggested that the lower risk of diverticula of intestine associated with metformin use was significant in all age groups of <50, 50-64 and >= 65 years, but the magnitude of risk reduction attenuated with increasing age.
   Conclusion: Metformin treatment is associated with a significantly reduced risk of diverticula of intestine.
C1 [Tseng, Chin-Hsiao] Natl Taiwan Univ, Dept Internal Med, Coll Med, Taipei, Taiwan.
   [Tseng, Chin-Hsiao] Natl Taiwan Univ Hosp, Dept Internal Med, Div Endocrinol & Metab, Taipei, Taiwan.
   [Tseng, Chin-Hsiao] Natl Hlth Res Inst, Div Environm Hlth & Occupat Med, Zhunan, Taiwan.
C3 National Taiwan University; National Taiwan University; National Taiwan
   University Hospital; National Health Research Institutes - Taiwan
RP Tseng, CH (通讯作者)，Natl Taiwan Univ, Dept Internal Med, Coll Med, Taipei, Taiwan.; Tseng, CH (通讯作者)，Natl Taiwan Univ Hosp, Dept Internal Med, Div Endocrinol & Metab, Taipei, Taiwan.; Tseng, CH (通讯作者)，Natl Hlth Res Inst, Div Environm Hlth & Occupat Med, Zhunan, Taiwan.
EM ccktsh@ms6.hinet.net
FU Ministry of Science and Technology [MOST 107-2221-E002-129-MY3]; Yee
   Fong Charity Foundation
FX The Ministry of Science and Technology (MOST 107-2221-E002-129-MY3) and
   the Yee Fong Charity Foundation provided financial support for the
   study.
CR Austin PC, 2015, STAT MED, V34, P3661, DOI 10.1002/sim.6607
   Austin PC, 2013, STAT MED, V32, P2837, DOI 10.1002/sim.5705
   Chang L, 2004, THESIS NATL YANG MIN
   Chen F, 2018, J MED CHEM, V61, P7330, DOI 10.1021/acs.jmedchem.8b00906
   Chen LG, 2010, PHARMACOGENET GENOM, V20, P687, DOI 10.1097/FPC.0b013e32833fe789
   Chen TC, 2021, J FORMOS MED ASSOC, V120, P810, DOI 10.1016/j.jfma.2020.09.011
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Freckelton J, 2017, SCAND J GASTROENTERO, V52, P969, DOI 10.1080/00365521.2017.1325930
   Hawkins AT, 2020, CURR PROB SURG, V57, DOI 10.1016/j.cpsurg.2020.100862
   He L, 2020, TRENDS PHARMACOL SCI, V41, P868, DOI 10.1016/j.tips.2020.09.001
   Hsieh CY, 2019, CLIN EPIDEMIOL, V11, P349, DOI 10.2147/CLEP.S196293
   Khan RMA, 2018, COLORECTAL DIS, V20, P469, DOI 10.1111/codi.14064
   Lee CB, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22073566
   Maniar K, 2017, PHARMACOL RES, V117, P103, DOI 10.1016/j.phrs.2016.12.003
   Peery AF, 2016, CLIN GASTROENTEROL H, V14, P980, DOI 10.1016/j.cgh.2016.01.020
   Piscopo Naomi, 2020, Ulster Med J, V89, P83
   Ranganathan Priya, 2016, Perspect Clin Res, V7, P51, DOI 10.4103/2229-3485.173773
   Regnier M, 2021, J ENDOCRINOL, V248, pR67, DOI 10.1530/JOE-20-0473
   Ryan PM, 2020, CAN J DIABETES, V44, P146, DOI 10.1016/j.jcjd.2019.05.008
   Strate LL, 2019, GASTROENTEROLOGY, V156, P1282, DOI 10.1053/j.gastro.2018.12.033
   Tseng CH, 2019, DIABETES METAB, V45, P458, DOI 10.1016/j.diabet.2019.05.002
   Tseng CH, 2021, FRONT PHARMACOL, V11, DOI 10.3389/fphar.2020.578831
   Tseng CH, 2021, J CROHNS COLITIS, V15, P64, DOI 10.1093/ecco-jcc/jjaa136
   Tseng CH, 2018, J CLIN MED, V7, DOI 10.3390/jcm7090264
   Tseng CH, 2018, DIABETES CARE, V41, pE42, DOI 10.2337/dc17-2551
   Tseng CH, 2012, EUR J ENDOCRINOL, V167, P409, DOI 10.1530/EJE-12-0369
   Tursi A, 2020, NAT REV DIS PRIMERS, V6, DOI 10.1038/s41572-020-0153-5
   Yang JF, 2021, CURR OPIN CLIN NUTR, V24, P127, DOI 10.1097/MCO.0000000000000709
NR 28
TC 5
Z9 5
U1 0
U2 3
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD SEP 7
PY 2021
VL 12
AR 739141
DI 10.3389/fphar.2021.739141
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA US3HW
UT WOS:000697325500001
PM 34557103
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Alvarez-Silva, C
   Kashani, A
   Hansen, TH
   Pinna, NK
   Anjana, RM
   Dutta, A
   Saxena, S
   Stoy, J
   Kampmann, U
   Nielsen, T
   Jorgensen, T
   Gnanaprakash, V
   Gnanavadivel, R
   Sukumaran, A
   Rani, CSS
   Faerch, K
   Radha, V
   Balasubramanyam, M
   Nair, GB
   Das, B
   Vestergaard, H
   Hansen, T
   Mande, SS
   Mohan, V
   Arumugam, M
   Pedersen, O
AF Alvarez-Silva, Camila
   Kashani, Alireza
   Hansen, Tue Haldor
   Pinna, Nishal Kumar
   Anjana, Ranjit Mohan
   Dutta, Anirban
   Saxena, Shruti
   Stoy, Julie
   Kampmann, Ulla
   Nielsen, Trine
   Jorgensen, Torben
   Gnanaprakash, Visvanathan
   Gnanavadivel, Rameshkumar
   Sukumaran, Aswath
   Rani, Coimbatore Subramanian Shanthi
   Faerch, Kristine
   Radha, Venkatesan
   Balasubramanyam, Muthuswamy
   Nair, Gopinath Balakrish
   Das, Bhabatosh
   Vestergaard, Henrik
   Hansen, Torben
   Mande, Sharmila Shekhar
   Mohan, Viswanathan
   Arumugam, Manimozhiyan
   Pedersen, Oluf
TI Trans-ethnic gut microbiota signatures of type 2 diabetes in Denmark and
   India
SO GENOME MEDICINE
LA English
DT Article
DE Gut microbiota; Trans-ethnic; Indians; Danes; Populations; Type 2
   diabetes; Metformin
ID RNA GENE DATABASE; METFORMIN; INDIVIDUALS; DANISH; COHORT
AB Background Type 2 diabetes (T2D), a multifactorial disease influenced by host genetics and environmental factors, is the most common endocrine disease. Several studies have shown that the gut microbiota as a close-up environmental mediator influences host physiology including metabolism. The aim of the present study is to examine the compositional and functional potential of the gut microbiota across individuals from Denmark and South India with a focus on T2D. Many earlier studies have investigated the microbiome aspects of T2D, and it has also been anticipated that such microbial associations would be dependent on diet and ethnic origin. However, there has been no large scale trans-ethnic microbiome study earlier in this direction aimed at evaluating any "universal" microbiome signature of T2D. Methods 16S ribosomal RNA gene amplicon sequencing was performed on stool samples from 279 Danish and 294 Indian study participants. Any differences between the gut microbiota of both populations were explored using diversity measures and negative binomial Wald tests. Study samples were stratified to discover global and country-specific microbial signatures for T2D and treatment with the anti-hyperglycemic drug, metformin. To identify taxonomical and functional signatures of the gut microbiota for T2D and metformin treatment, we used alpha and beta diversity measures and differential abundances analysis, comparing metformin-naive T2D patients, metformin-treated T2D patients, and normoglycemic individuals. Results Overall, the gut microbial communities of Danes and Indians are compositionally very different. By analyzing the combined study materials, we identify microbial taxonomic and functional signatures for T2D and metformin treatment. T2D patients have an increased relative abundance of two operational taxonomic units (OTUs) from the Lachnospiraceae family, and a decreased abundance of Subdoligranulum and Butyricicoccus. Studying each population per se, we identified T2D-related microbial changes at the taxonomic level within the Danish population only. Alpha diversity indices show that there is no significant difference between normoglycemic individuals and metformin-naive T2D patients, whereas microbial richness is significantly decreased in metformin-treated T2D patients compared to metformin-naive T2D patients and normoglycemic individuals. Enrichment of two OTUs from Bacteroides and depletion of Faecalibacterium constitute a trans-ethnic signature of metformin treatment. Conclusions We demonstrate major compositional differences of the gut microbiota between Danish and South Indian individuals, some of which may relate to differences in ethnicity, lifestyle, and demography. By comparing metformin-naive T2D patients and normoglycemic individuals, we identify T2D-related microbiota changes in the Danish and Indian study samples. In the present trans-ethnic study, we confirm that metformin changes the taxonomic profile and functional potential of the gut microbiota.
C1 [Alvarez-Silva, Camila; Kashani, Alireza; Hansen, Tue Haldor; Vestergaard, Henrik; Hansen, Torben; Arumugam, Manimozhiyan; Pedersen, Oluf] Univ Copenhagen, Novo Nordisk Fdn, Ctr Basic Metab Res, Blegdamsvej 3B, DK-2200 Copenhagen N, Denmark.
   [Kashani, Alireza; Nielsen, Trine] Odense Univ Hosp, Danish Acad Diabet, Klovervaenget 6, DK-5000 Odense C, Denmark.
   [Hansen, Tue Haldor] Slagelse Hosp, Dept Cardiol & Endocrinol, Slagelse, Denmark.
   [Pinna, Nishal Kumar; Dutta, Anirban; Mande, Sharmila Shekhar] Tata Consultancy Serv Ltd, TCS Res, 54B Hadapsar Ind Estate, Pune 411013, Maharashtra, India.
   [Anjana, Ranjit Mohan; Gnanaprakash, Visvanathan; Gnanavadivel, Rameshkumar; Sukumaran, Aswath; Rani, Coimbatore Subramanian Shanthi; Radha, Venkatesan; Balasubramanyam, Muthuswamy; Mohan, Viswanathan] Madras Diabet Res Fdn, 4 Conran Smith Rd, Chennai 600086, Tamil Nadu, India.
   [Saxena, Shruti; Nair, Gopinath Balakrish; Das, Bhabatosh] NCR Biotech Sci Cluster, Translat Hlth Sci & Technol Inst, Mol Genet Lab, Infect & Immunol, Faridabad 121001, India.
   [Stoy, Julie; Kampmann, Ulla; Faerch, Kristine] Aarhus Universitetshosp, Steno Diabet Ctr Aarhus, Hedeager 3,2 Sal, DK-8200 Aarhus, Denmark.
   [Jorgensen, Torben] Univ Copenhagen, Bispebjerg & Frederiksberg Hosp, Ctr Clin Res & Prevent, Copenhagen, Denmark.
   [Arumugam, Manimozhiyan] Univ Southern Denmark, Fac Hlth Sci, Odense, Denmark.
C3 Novo Nordisk Foundation; University of Copenhagen; University of
   Southern Denmark; Odense University Hospital; Tata Sons; Tata
   Consultancy Services Limited (TCS); Madras Diabetes Research Foundation;
   Department of Biotechnology (DBT) India; Translational Health Science &
   Technology Institute (THSTI); University of Copenhagen; Bispebjerg
   Hospital; University of Southern Denmark
RP Arumugam, M; Pedersen, O (通讯作者)，Univ Copenhagen, Novo Nordisk Fdn, Ctr Basic Metab Res, Blegdamsvej 3B, DK-2200 Copenhagen N, Denmark.; Mande, SS (通讯作者)，Tata Consultancy Serv Ltd, TCS Res, 54B Hadapsar Ind Estate, Pune 411013, Maharashtra, India.; Mohan, V (通讯作者)，Madras Diabet Res Fdn, 4 Conran Smith Rd, Chennai 600086, Tamil Nadu, India.
EM sharmila.mande@tcs.com; drmohans@diabetes.ind.in; arumugam@sund.ku.dk;
   oluf@sund.ku.dk
RI Pinna, Nishal Kumar/HTL-2678-2023; Arumugam, Manimozhiyan/AAJ-2394-2020;
   Pedersen, Oluf/Z-1731-2019; Hansen, Tue Haldor/S-7724-2016; Nielsen,
   trine/HJZ-4867-2023; Kampmann, Ulla/ISA-2654-2023; Arumugam,
   Manimozhiyan/E-1211-2011; Dutta, Anirban/B-1519-2010
OI Arumugam, Manimozhiyan/0000-0002-0886-9101; Pedersen,
   Oluf/0000-0002-3321-3972; Hansen, Tue Haldor/0000-0001-5948-8993;
   Nielsen, trine/0000-0002-2066-7895; Arumugam,
   Manimozhiyan/0000-0002-0886-9101; Vestergaard,
   Henrik/0000-0003-3090-269X; Alvarez-Silva, Maria
   Camila/0000-0002-7905-2967; Dutta, Anirban/0000-0002-8209-026X; Hansen,
   Torben/0000-0001-8748-3831; Kampmann, Ulla/0000-0002-2234-7780
FU Innovation Fund of Denmark [0603-00591B]; Department of Biotechnology,
   Govt. of India [BT/IN/Denmark/12/VM/2013]; Novo Nordisk Foundation
   [NNF10CC1016515, NNF18CC0034900, NNF16CC0020896]; Danish Diabetes
   Academy - Novo Nordisk Foundation
FX This work was supported by funds from Innovation Fund of Denmark (grant
   number 0603-00591B) and the Department of Biotechnology, Govt. of India
   (BT/IN/Denmark/12/VM/2013) to "MicrobDiab -Studies of interactions
   between the gut microbiome and the human host biology to elucidate novel
   aspects of the pathophysiology and pathogenesis of type 2 Diabetes". It
   was also supported by Novo Nordisk Foundation (grant numbers
   NNF10CC1016515 and NNF18CC0034900). CAS was supported by Novo Nordisk
   Foundation (grant NNF16CC0020896). AK was supported by the Danish
   Diabetes Academy supported by the Novo Nordisk Foundation.
CR Allin KH, 2018, DIABETOLOGIA, V61, P810, DOI 10.1007/s00125-018-4550-1
   [Anonymous], 2019, PRJNA517829 NCBI SRA
   Beaumont M, 2016, GENOME BIOL, V17, DOI 10.1186/s13059-016-1052-7
   Bhute S, 2016, FRONT MICROBIOL, V7, DOI 10.3389/fmicb.2016.00660
   Cabreiro F, 2016, CELL HOST MICROBE, V19, P1, DOI 10.1016/j.chom.2015.12.012
   Callahan Ben J, 2016, F1000Res, V5, P1492
   Callahan BJ, 2016, NAT METHODS, V13, P581, DOI [10.1038/NMETH.3869, 10.1038/nmeth.3869]
   Caporaso JG, 2010, NAT METHODS, V7, P335, DOI 10.1038/nmeth.f.303
   Dantoft TM, 2017, CLIN EPIDEMIOL, V9, P127, DOI 10.2147/CLEP.S129335
   David LA, 2014, NATURE, V505, P559, DOI 10.1038/nature12820
   DeFronzo RA, 2000, ENDOTEXT
   DeSantis TZ, 2006, APPL ENVIRON MICROB, V72, P5069, DOI 10.1128/AEM.03006-05
   Edgar RC, 2010, BIOINFORMATICS, V26, P2460, DOI 10.1093/bioinformatics/btq461
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Godon JJ, 1997, APPL ENVIRON MICROB, V63, P2802, DOI 10.1128/AEM.63.7.2802-2813.1997
   Goodrich JK, 2016, CELL HOST MICROBE, V19, P731, DOI 10.1016/j.chom.2016.04.017
   Gupta VK, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.01162
   Hartmann M, 2010, J MICROBIOL METH, V83, P250, DOI 10.1016/j.mimet.2010.08.008
   Johansen NB, 2012, BMC PUBLIC HEALTH, V12, DOI 10.1186/1471-2458-12-1078
   Langille MGI, 2013, NAT BIOTECHNOL, V31, P814, DOI 10.1038/nbt.2676
   Love MI, 2014, GENOME BIOL, V15, DOI 10.1186/s13059-014-0550-8
   McMurdie PJ, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0061217
   Nagpal S, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0148347
   Nishijima S, 2016, DNA RES, V23, P125, DOI 10.1093/dnares/dsw002
   Pryor R, 2015, BIOCHEM J, V471, P307, DOI 10.1042/BJ20150497
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Quast C, 2013, NUCLEIC ACIDS RES, V41, pD590, DOI 10.1093/nar/gks1219
   Sircana A, 2018, CURR DIABETES REP, V18, DOI 10.1007/s11892-018-1057-6
   Stirling C, 2010, BMC HEALTH SERV RES, V10, DOI 10.1186/1472-6963-10-122
   Urpi-Sarda M, 2015, CURR CARDIOVASC RISK, V9, DOI 10.1007/s12170-015-0440-y
   Wu GD, 2011, SCIENCE, V334, P105, DOI 10.1126/science.1208344
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Zhang XY, 2009, J PROTEOME RES, V8, P5188, DOI 10.1021/pr900524z
NR 33
TC 18
Z9 21
U1 1
U2 13
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1756-994X
J9 GENOME MED
JI Genome Med.
PD MAR 3
PY 2021
VL 13
IS 1
AR 37
DI 10.1186/s13073-021-00856-4
PG 13
WC Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity
GA QS0TE
UT WOS:000625620700002
PM 33658058
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Song, ZC
   Luo, WM
   Huang, B
   Cao, YF
   Jiang, RZ
AF Song, Zicheng
   Luo, Weiming
   Huang, Bing
   Cao, Yunfeng
   Jiang, Rongzhen
TI A new predictive model for the concurrent risk of diabetic retinopathy
   in type 2 diabetes patients and the effect of metformin on amino acids
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE amino acids; new predictive model; metformin; PLS; DR
ID GUT MICROBIOTA; METABOLISM; METAGENOME; PATHWAY
AB ObjectiveThis study established a model to predict the risk of diabetic retinopathy (DR) with amino acids selected by partial least squares (PLS) method, and evaluated the effect of metformin on the effect of amino acids on DR in the model. MethodsIn Jinzhou, Liaoning Province, China, we retrieved 1031 patients with type 2 diabetes (T2D) from the First Affiliated Hospital of Liaoning Medical University. After sorting the amino acids using the PLS method, the top 10 amino acids were included in the model. Multivariate logistic regression was used to analyze the relationship between different amino acids and DR. And then the effects of metformin on amino acids were explored through interaction. Finally, Spearman's rank correlation analysis was used to analyze the correlation between different amino acids. ResultsAfter sorting by PLS, Gly, Pro, Leu, Lyr, Glu, Phe, Tyr, His, Val and Ser were finally included in the DR risk prediction model. The predictive model after adding amino acids was statistically different from the model that only included traditional risk factors (p=0.001). Metformin had a significant effect on the relationship between DR and 7 amino acids (Gly, Glu, Phe, Tyr, His, Val, Ser, p<0.05), and the population who are not using metformin and have high levels of Glu (OR: 0.44, 95%CI: 0.27-0.71) had an additive protection effect for the occurrence of DR. And the similar results can be seen in high levels of Gly (OR: 0.46, 95%CI: 0.29-0.75), Leu (OR: 0.48, 95%CI: 0.29-0.8), His (OR: 0.46, 95%CI: 0.29-0.75), Phe (OR: 0.24, 95%CI: 0.14-0.42) and Tyr (OR: 0.41, 95%CI: 0.24 -0.68) in population who are not using metformin. ConclusionsWe established a prediction model of DR by amino acids and found that the use of metformin reduced the protective effect of amino acids on DR developing, suggesting that amino acids as biomarkers for predicting DR would be affected by metformin use.
C1 [Song, Zicheng; Jiang, Rongzhen] Shanghai Jiao Tong Univ, Dept Obstet & Gynecol, Affiliated Peoples Hosp 6, Shanghai, Peoples R China.
   [Luo, Weiming] Tianjin Med Univ, Sch Publ Hlth, Dept Toxicol & Sanit Chem, Tianjin, Peoples R China.
   [Huang, Bing] Dalian Innovat Ctr Lab Med Mass Spectrometry Techn, Res Dept, Dalian, Peoples R China.
   [Huang, Bing] Clin Mass Spectrometry Profess Technol Innovat Ctr, Res Dept, Jinzhou, Peoples R China.
   [Huang, Bing] Dalian Lab Med Mass Spectrometry Technol Dev Innov, Res Dept, Dalian, Peoples R China.
   [Cao, Yunfeng] Shanghai Inst Planned Parenthood Res, Dept Sci Res, Shanghai, Peoples R China.
   [Cao, Yunfeng] Chinese Acad Sci, Dalian Inst Chem Phys, Dalian, Peoples R China.
C3 Shanghai Jiao Tong University; Tianjin Medical University; Chinese
   Academy of Sciences; Dalian Institute of Chemical Physics, CAS
RP Jiang, RZ (通讯作者)，Shanghai Jiao Tong Univ, Dept Obstet & Gynecol, Affiliated Peoples Hosp 6, Shanghai, Peoples R China.; Cao, YF (通讯作者)，Shanghai Inst Planned Parenthood Res, Dept Sci Res, Shanghai, Peoples R China.; Cao, YF (通讯作者)，Chinese Acad Sci, Dalian Inst Chem Phys, Dalian, Peoples R China.
EM cyf2005yjs@163.com; jianrzh@163.com
RI Cao, Yunfeng/S-1593-2016
FU Development and clinical application of mass spectrometry methods for
   small molecule metabolic pathways; Dalian Innovation Center of
   Laboratory Medicine Mass Spectrometry Technology;  [2021RT09]
FX Funding This work was supported by the Development and clinical
   application of mass spectrometry methods for small molecule metabolic
   pathways (Project No. 2021RT09), Dalian Innovation Center of Laboratory
   Medicine Mass Spectrometry Technology. The funders had no role in study
   design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
CR Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   Alex A, 2020, INVEST OPHTH VIS SCI, V61, DOI 10.1167/iovs.61.6.46
   Alomar SY, 2021, INT IMMUNOPHARMACOL, V90, DOI 10.1016/j.intimp.2020.107193
   Campbell JM, 2017, AGEING RES REV, V40, P31, DOI 10.1016/j.arr.2017.08.003
   Caturano A, 2019, JAMA-J AM MED ASSOC, V322, P1312, DOI 10.1001/jama.2019.11489
   Chen Chunming, 2004, Biomed Environ Sci, V17 Suppl, P1
   Ciarlo E, 2016, SCI REP-UK, V6, DOI 10.1038/srep37944
   Dai ZL, 2011, FRONT BIOSCI-LANDMRK, V16, P1768, DOI 10.2741/3820
   De Silva K, 2020, INT J MED INFORM, V143, DOI 10.1016/j.ijmedinf.2020.104268
   Duca FA, 2015, NAT MED, V21, P506, DOI 10.1038/nm.3787
   Faselis C, 2020, CURR VASC PHARMACOL, V18, P117, DOI 10.2174/1570161117666190502103733
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Fregoso-Aparicio L, 2021, DIABETOL METAB SYNDR, V13, DOI 10.1186/s13098-021-00767-9
   Galiero R, 2020, J DIABETES RES, V2020, DOI 10.1155/2020/9036847
   Guo CN, 2022, ENDOCR CONNECT, V11, DOI 10.1530/EC-21-0474
   Hsu SK, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22179453
   International Diabetes Federation (IDF), 2021, DIABETES ATLAS
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kavakiotis I, 2017, COMPUT STRUCT BIOTEC, V15, P104, DOI 10.1016/j.csbj.2016.12.005
   Li WY, 2021, BMJ OPEN, V11, DOI 10.1136/bmjopen-2021-050989
   Liew G, 2014, BMJ OPEN, V4, DOI 10.1136/bmjopen-2013-004015
   Lin R, 2017, AMINO ACIDS, V49, P2083, DOI 10.1007/s00726-017-2493-3
   Ma T, 2022, NATURE, V603, P159, DOI 10.1038/s41586-022-04431-8
   Mardinoglu A, 2015, MOL SYST BIOL, V11, DOI 10.15252/msb.20156487
   McCreight LJ, 2016, DIABETOLOGIA, V59, P426, DOI 10.1007/s00125-015-3844-9
   Metges CC, 2000, J NUTR, V130, p1857S, DOI 10.1093/jn/130.7.1857S
   Miles JM, 2014, CURR DIABETES REP, V14, DOI 10.1007/s11892-014-0490-4
   Mu CL, 2017, AMINO ACIDS, V49, P771, DOI 10.1007/s00726-017-2379-4
   Neis EPJG, 2015, NUTRIENTS, V7, P2930, DOI 10.3390/nu7042930
   Oh E, 2013, BMC MED INFORM DECIS, V13, DOI 10.1186/1472-6947-13-106
   Park SY, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-83165-5
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Rhee SY, 2018, METABOLOMICS, V14, DOI 10.1007/s11306-018-1383-3
   Rinaldi L, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10020270
   Salvatore T, 2020, DIABETES RES CLIN PR, V160, DOI 10.1016/j.diabres.2020.108025
   Sasso FC, 2019, DIABETES-METAB RES, V35, DOI 10.1002/dmrr.3113
   Vujosevic S, 2020, LANCET DIABETES ENDO, V8, P337, DOI 10.1016/S2213-8587(19)30411-5
   Wang QJ, 2016, ONCOTARGETS THER, V9, P1389, DOI 10.2147/OTT.S95862
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Yau JWY, 2012, DIABETES CARE, V35, P556, DOI 10.2337/dc11-1909
   Zhou ZX, 2021, FRONT CELL DEV BIOL, V9, DOI 10.3389/fcell.2021.732204
NR 41
TC 0
Z9 0
U1 4
U2 4
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD AUG 18
PY 2022
VL 13
AR 985776
DI 10.3389/fendo.2022.985776
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 4O8YJ
UT WOS:000854979600001
PM 36060930
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Wang, JH
   Bose, S
   Shin, NR
   Chin, YW
   Choi, YH
   Kim, H
AF Wang, Jing-Hua
   Bose, Shambhunath
   Shin, Na Rae
   Chin, Young-Won
   Choi, Young Hee
   Kim, Hojun
TI Pharmaceutical Impact of Houttuynia Cordata and Metformin Combination on
   High-Fat-Diet-Induced Metabolic Disorders: Link to Intestinal Microbiota
   and Metabolic Endotoxemia
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE Houttuynia cordate; type 2 diabetes; high fat diet; gut microbiota;
   endotoxin
ID DEPENDENT DIABETES-MELLITUS; GLUCOSE-TOLERANCE TEST; INSULIN
   SENSITIVITY; GUT MICROBIOTA; LIVER; RATS; MICE; INFLAMMATION;
   GLUCONEOGENESIS; ACTIVATION
AB Purpose: Metformin and Houttuynia cordata are representative anti-diabetic therapeutic agents in western and oriental medicinal fields, respectively. The present study examined the therapeutic effects of houttuynia cordata extract (HOE) and metformin in combination in a dysmetabolic mouse model.
   Methods: Metabolic disorders were induced in C57BL/6J mice by high fat diet (HFD) for 14 weeks.
   Results: Combination of metformin and HCE significantly lowered body weight, abdominal fat, perirenal fat, liver and kidney weights, but did not change epididymal fat in HFD-fed animals. Metformin + HCE treatment markedly attenuated the elevated serum levels of TG, TC, AST, ALT, and endotoxin and restored the depleted HDL level. Both HCE and metformin + HCE treatment ameliorated glucose tolerance and high level of fasting blood glucose in association with AMPK activation. Moreover, treatment with HCE + metformin dramatically suppressed inflammation in HFD-fed animals via inhibition of proinflammatory cytokines (MCP-1 and IL-6) and LPS receptor (TLR4). Histopathological findings showed that exposure of HFD-treated animals to metformin + HCE ameliorated fatty liver, shrinkage of intestinal villi and adipocytes enlargement. Furthermore, HOE and metformin + HCE treatments markedly modulated the abundance of gut Gram-negative bacteria, including Escherichia coli and Bacteriodetes fragilis, but not universal Gram-positive bacteria.
   Conclusions: Overall, HCE and metformin cooperatively exert their therapeutic effects via modulation of gut microbiota, especially reduction of Gram-negative bacteria, resulting in alleviation of endotoxemia.
C1 [Wang, Jing-Hua; Shin, Na Rae; Kim, Hojun] Dongguk Univ, Dept Oriental Rehabil Med, Goyang, South Korea.
   [Bose, Shambhunath] NosQuest, Seongnam Si, South Korea.
   [Chin, Young-Won] Dongguk Univ Seoul, Coll Pharm, Goyang, South Korea.
   [Choi, Young Hee] Dongguk Univ Seoul, Coll Pharm, Seoul, South Korea.
   [Choi, Young Hee] Dongguk Univ Seoul, Integrated Res Inst Drug Dev, Seoul, South Korea.
C3 Dongguk University; Dongguk University; Dongguk University; Dongguk
   University
RP Kim, H (通讯作者)，Dongguk Univ, Dept Oriental Rehabil Med, Goyang, South Korea.
EM kimklar@dongguk.ac.kr
RI Bose, Shambhunath/HKW-2568-2023; Kim, Hojun/AAB-8405-2020; Wang,
   Jing-hua/AAO-2350-2020
OI Wang, Jing-hua/0000-0002-2034-7429; Chin, Young-Won/0000-0001-6964-1779;
   Bose, Shambunath/0000-0003-0737-5713; Choi, Young
   Hee/0000-0002-9360-6436
FU Convergence of Conventional Medicine and Traditional Korean Medicine R&D
   program - Ministry of Health and Welfare through the Korea Health
   Industry Development Institute [HI14C0558]; National Research Foundation
   of Korea - Korean Government [NRF-2016R1A2B4014225]
FX This work was supported by a grant from the Convergence of Conventional
   Medicine and Traditional Korean Medicine R&D program funded by the
   Ministry of Health and Welfare through the Korea Health Industry
   Development Institute (HI14C0558). This work was also supported by the
   National Research Foundation of Korea Grant funded by the Korean
   Government (NRF-2016R1A2B4014225).
CR Adamo Kristi B, 2008, Novartis Found Symp, V293, P103
   Al-Attas OS, 2009, CARDIOVASC DIABETOL, V8, DOI 10.1186/1475-2840-8-20
   Bergheim I, 2006, J PHARMACOL EXP THER, V316, P1053, DOI 10.1124/jpet.105.092122
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   Carding Simon, 2015, Microbial Ecology in Health and Disease, V26, P26191, DOI 10.3402/mehd.v26.26191
   Chen YY, 2003, J NUTR SCI VITAMINOL, V49, P327, DOI 10.3177/jnsv.49.327
   D'souza AM, 2012, AM J PHYSIOL-GASTR L, V302, pG850, DOI 10.1152/ajpgi.00378.2011
   Daniel H, 2014, ISME J, V8, P295, DOI 10.1038/ismej.2013.155
   Dhanya R, 2017, FRONT PHARMACOL, V8, DOI 10.3389/fphar.2017.00336
   Eslinger AJ, 2014, NUTR RES, V34, P714, DOI 10.1016/j.nutres.2014.07.016
   FDA Guidance for Industry, 2005, EST MAX SAF START DO
   Foretz M, 2010, J CLIN INVEST, V120, P2355, DOI 10.1172/JCI40671
   Gutch Manish, 2015, Indian J Endocrinol Metab, V19, P160, DOI 10.4103/2230-8210.146874
   Han EH, 2009, FOOD CHEM TOXICOL, V47, P1659, DOI 10.1016/j.fct.2009.04.025
   JACKSON WPU, 1979, S AFR MED J, V56, P1113
   Kalariya NM, 2012, INVEST OPHTH VIS SCI, V53, P3431, DOI 10.1167/iovs.12-9432
   Kang H, 2015, PHARM BIOL, V53, P414, DOI 10.3109/13880209.2014.923002
   Kim KA, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0047713
   Kim SK, 2001, ARCH PHARM RES, V24, P518, DOI 10.1007/BF02975156
   Koh SJ, 2014, J GASTROEN HEPATOL, V29, P502, DOI 10.1111/jgh.12435
   Kumar M, 2014, ADV PHARMACOL SCI, V2014, DOI 10.1155/2014/809438
   Lau KM, 2008, J ETHNOPHARMACOL, V118, P79, DOI 10.1016/j.jep.2008.03.018
   Lee JH, 2015, ARCH PHARM RES, V38, P1304, DOI 10.1007/s12272-015-0585-8
   Li GZ, 2005, BIOL PHARM BULL, V28, P1864, DOI 10.1248/bpb.28.1864
   Li WF, 2013, PHYTOTHER RES, V27, P1629, DOI 10.1002/ptr.4905
   Li XC, 2016, MOLECULES, V21, DOI 10.3390/molecules21091246
   Meng XM, 2017, EUR REV MED PHARMACO, V21, P2232
   Miyata M, 2010, J NUTR SCI VITAMINOL, V56, P150, DOI 10.3177/jnsv.56.150
   Musso G, 2010, CURR OPIN LIPIDOL, V21, P76, DOI 10.1097/MOL.0b013e3283347ebb
   Ota S, 2009, BIOCHEM BIOPH RES CO, V388, P311, DOI 10.1016/j.bbrc.2009.07.164
   PRAGER R, 1986, DIABETES METAB, V12, P346
   Radziuk J, 1997, DIABETES, V46, P1406, DOI 10.2337/diabetes.46.9.1406
   Roglic G, 2015, DIABETES RES CLIN PR, V108, P367, DOI 10.1016/j.diabres.2015.03.010
   Schmidt I, 2002, NEWS PHYSIOL SCI, V17, P115, DOI 10.1152/nips.01380.2001
   Sekita Y, 2016, BIOSCI BIOTECH BIOCH, V80, P1205, DOI 10.1080/09168451.2016.1151339
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Soonthornpun S, 2003, J CLIN ENDOCR METAB, V88, P1019, DOI 10.1210/jc.2002-021127
   Stumvoll M, 2000, DIABETES CARE, V23, P295, DOI 10.2337/diacare.23.3.295
   STUMVOLL M, 1995, NEW ENGL J MED, V333, P550, DOI 10.1056/NEJM199508313330903
   Tian LM, 2012, J AGR FOOD CHEM, V60, P4641, DOI 10.1021/jf3008376
   Tong EHY, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0008435
   Wang HY, 2012, J TRADIT CHIN MED, V32, P58, DOI 10.1016/S0254-6272(12)60032-6
   Wang JH, 2017, GENES-BASEL, V8, DOI 10.3390/genes8100239
   Wang JH, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0086117
NR 45
TC 30
Z9 31
U1 1
U2 13
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD OCT 24
PY 2018
VL 9
AR 620
DI 10.3389/fendo.2018.00620
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA GX9IM
UT WOS:000448115300001
PM 30405531
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Sahin, K
   Sahinturk, Y
   Koker, G
   Koker, GO
   Bostan, F
   Kok, M
   Uyar, S
   Cekin, AH
AF Sahin, Kubra
   Sahinturk, Yasin
   Koker, Gokhan
   Koker, Gulhan Ozcelik
   Bostan, Feyzi
   Kok, Mehmet
   Uyar, Seyit
   Cekin, Ayhan Hilmi
TI Metformin with Versus without Concomitant Probiotic Therapy in Newly
   Diagnosed Patients with Type 2 Diabetes or Prediabetes: A Comparative
   Analysis in Relation to Glycemic Control, Gastrointestinal Side Effects,
   and Treatment Compliance
SO TURKISH JOURNAL OF GASTROENTEROLOGY
LA English
DT Article
DE Type 2 diabetes; metformin; probiotic; BB-12; gastrointestinal
   intolerance; glycemic control; lipids; body weight; compliance
ID GUT MICROBIOME; WEIGHT-LOSS; SYMPTOMS; INTOLERANCE; PREVENTION; ACID
AB Background: To evaluate the impact of concomitant use of probiotic BB-12 in metformin-treated patients with type 2 diabetes or prediabetes on glycemic control, metformin-related gastrointestinal side effects, and treatment compliance.
   Methods: A total of 156 patients (mean [standard deviation] age: 50.9 [9.9 years], 74.4% females) with newly diagnosed type 2 diabetes or prediabetes were randomly assigned to receive either metformin alone (n = 84, MET group) or metformin plus Bifidobacterium animalis subsp. lactis (BB-12) probiotic (n = 72, MET-PRO group). Data on body mass index (kg/m(2)), fasting blood glucose (mg/dL), blood lipids, and glycated hemoglobin (HbA1c) levels were recorded at baseline and at the third month of therapy. Data on gastrointestinal intolerance symptoms and treatment noncompliance were also recorded during post-treatment week 1 to week 4.
   Results: MET-PRO versus MET therapy was associated with a significantly higher rate of treatment compliance (91.7% vs 71.4%, P = .001), greater reduction from baseline HbA1c values (0.9 [0.4-1.6] vs 0.4 [0-1.6] %, P < .001) and lower likelihood of gastrointestinal intolerance symptoms, including abdominal pain (P = .031 to < .001), diarrhea (P = .005 to < .001) and bloating (P = .010 to < .001). Noncompliance developed later (at least 15 days after the therapy) in a significantly higher percentage of patients in the MET group (P =.001 for 15-21 days and P = .002 for 22-28 days).
   Conclusion: In conclusion, the present study proposes the benefit of combining probiotics with metformin in the treatment of patients with T2D or prediabetes in terms of improved glycemic control and treatment adherence rather than correction of dyslipidemia or weight reduction.
C1 [Sahin, Kubra; Sahinturk, Yasin; Koker, Gokhan; Koker, Gulhan Ozcelik; Bostan, Feyzi; Kok, Mehmet; Uyar, Seyit; Cekin, Ayhan Hilmi] Univ Hlth Sci, Antalya Training & Res Hosp, Dept Internal Med, Antalya, Turkey.
C3 Antalya Training & Research Hospital; University of Health Sciences
   Turkey
RP Sahinturk, Y (通讯作者)，Univ Hlth Sci, Antalya Training & Res Hosp, Dept Internal Med, Antalya, Turkey.
EM drsahinturk@yahoo.com
CR Adeshirlarijaney A, 2020, GUT MICROBES, V11, P253, DOI 10.1080/19490976.2020.1717719
   Adeshirlarijaney A, 2019, AM J PHYSIOL-ENDOC M, V317, pE1121, DOI 10.1152/ajpendo.00245.2019
   Aoki R, 2017, SCI REP-UK, V7, DOI 10.1038/srep43522
   Boerlage TCC, 2017, BRIT J SURG, V104, P393, DOI 10.1002/bjs.10419
   Bonnet F, 2017, DIABETES OBES METAB, V19, P473, DOI 10.1111/dom.12854
   Borgeraas H, 2018, OBES REV, V19, P219, DOI 10.1111/obr.12626
   Bray GA, 2012, DIABETES CARE, V35, P731, DOI 10.2337/dc11-1299
   Brunkwall L, 2017, DIABETOLOGIA, V60, P943, DOI 10.1007/s00125-017-4278-3
   Brusaferro A, 2018, NUTRIENTS, V10, DOI 10.3390/nu10111613
   Burton Jeffrey H, 2015, J Diabetes Sci Technol, V9, P808, DOI 10.1177/1932296815577425
   Caesar R, 2019, CAN J DIABETES, V43, P224, DOI 10.1016/j.jcjd.2019.01.007
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   DIMENAS E, 1995, SCAND J GASTROENTERO, V30, P1046, DOI 10.3109/00365529509101605
   Florez H, 2010, POSTGRAD MED, V122, P112, DOI 10.3810/pgm.2010.03.2128
   Groele L, 2017, BMJ OPEN, V7, DOI 10.1136/bmjopen-2017-017178
   Gurung M, 2020, EBIOMEDICINE, V51, DOI 10.1016/j.ebiom.2019.11.051
   Houghton D, 2018, DIABETOLOGIA, V61, P1700, DOI 10.1007/s00125-018-4632-0
   Huang YX, 2020, J CLIN PHARM THER, V45, P470, DOI 10.1111/jcpt.13087
   John GK, 2018, GENES-BASEL, V9, DOI 10.3390/genes9030167
   Jungersen Mikkel, 2014, Microorganisms, V2, P92, DOI 10.3390/microorganisms2020092
   Kim SH, 2014, J APPL MICROBIOL, V117, P834, DOI 10.1111/jam.12573
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Madempudi RS, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0225168
   Napolitano A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100778
   Olgun A, 2017, MED HYPOTHESES, V106, P33, DOI [10.1016/j.mehy.2017.07.009, 10.1016]
   Park S, 2015, NUTR RES, V35, P566, DOI 10.1016/j.nutres.2015.05.008
   Pyra KA, 2012, J NUTR, V142, P213, DOI 10.3945/jn.111.147132
   Razmpoosh E, 2016, DIABETES-METAB RES, V32, P143, DOI 10.1002/dmrr.2665
   Reimer RA, 2014, J ENDOCRINOL, V220, P361, DOI 10.1530/JOE-13-0484
   Rena G, 2017, DIABETOLOGIA, V60, P1577, DOI 10.1007/s00125-017-4342-z
   Singh S, 2017, BENEF MICROBES, V8, P243, DOI 10.3920/BM2016.0090
   Stenman LK, 2014, BENEF MICROBES, V5, P437, DOI 10.3920/BM2014.0014
   Stenman LK, 2015, DIABETOL METAB SYNDR, V7, DOI 10.1186/s13098-015-0075-7
   Tiderencel KA, 2020, DIABETES-METAB RES, V36, DOI 10.1002/dmrr.3213
   Wang YM, 2020, BIOMED PHARMACOTHER, V125, DOI 10.1016/j.biopha.2020.109914
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Yerevanian A, 2019, CURR OBES REP, V8, P156, DOI 10.1007/s13679-019-00335-3
   Zheng JL, 2018, J AGR FOOD CHEM, V66, P5821, DOI [10.1021/acsjafc.8b00829, 10.1021/acs.jafc.8b00829]
NR 38
TC 1
Z9 1
U1 0
U2 0
PU AVES
PI SISLI
PA BUYUKDERE CAD 105-9, MECIDIYEKOY, SISLI, ISTANBUL 34394, TURKEY
EI 2148-5607
J9 TURK J GASTROENTEROL
JI Turk. J. Gastroenterol.
PD NOV
PY 2022
VL 33
IS 11
BP 925
EP 933
DI 10.5152/tjg.2022.211063
PG 9
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 7A8BP
UT WOS:000898674900004
PM 36098362
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Ericsson, AC
   Johnson, PJ
   Gieche, LM
   Zobrist, C
   Bucy, K
   Townsend, KS
   Martin, LM
   LaCarrubba, AM
AF Ericsson, Aaron C.
   Johnson, Philip J.
   Gieche, Lyndsy M.
   Zobrist, Chelsea
   Bucy, Katie
   Townsend, Kile S.
   Martin, Lynn M.
   LaCarrubba, Alison M.
TI The Influence of Diet Change and Oral Metformin on Blood Glucose
   Regulation and the Fecal Microbiota of Healthy Horses
SO ANIMALS
LA English
DT Article
DE equine; metabolic syndrome; glucose tolerance
ID EQUINE METABOLIC SYNDROME; INSULIN SENSITIVITY; GUT MICROBIOTA;
   PHARMACOKINETICS; MODULATION; SEQUENCES; OBESITY; PONIES
AB Simple Summary
   Horses are susceptible to a condition known as Equine Metabolic Syndrome (EMS), which is somewhat similar to metabolic syndrome and type II diabetes in people, and is characterized by elevated insulin levels and increased susceptibility to other adverse health outcomes. Common treatments, including change to an all-hay diet and a drug called metformin, may provide benefits through modulation of intestinal bacteria, collectively known as the gut microbiota. In the studies reported here, horses undergoing such a diet change, regardless of the presence of metformin, showed a significant expansion in their fecal microbiota of a specific, poorly characterized group of bacteria. Notably, this phylum is distantly related to the bacteria found to expand in the fecal microbiota of mice and humans following metformin administration, suggesting removal from pasture to reduce the caloric intake may exert effects on the equine microbiota similar to those seen in other host species treated with metformin.
   Common treatments for Equine Metabolic Syndrome (EMS) and associated conditions include removal from pasture and adoption of an all-hay diet. Pharmacological treatments for EMS include metformin, a biguanide antihyperglycemic agent also administered to people to help improve glucose tolerance and insulin sensitivity. Both treatments may work, at least partially, through the gut microbiota, yet little is known regarding these effects in the equine host. To determine the influence on the fecal microbiota of this diet change and administration of metformin, six healthy horses were removed from pasture and switched to an all-hay diet, with four of those horses also receiving oral metformin for seven days. Control horses (n = 24) remaining on pasture and receiving no metformin were sampled at the beginning and end of one week. All samples were subjected to 16S rRNA sequencing, and horses undergoing the diet change were subjected to an oral sugar test twice, one week apart. Characteristic changes in the microbiota following diet change included the significant expansion of the phylum Kiritimatiellaeota. As Kiritimatiellaeota are related to Verrucomicrobia, found to expand in the microbiota of mice and humans in response to metformin, this taxon may represent the cognate microbes in equine hosts.
C1 [Ericsson, Aaron C.] Univ Missouri, Coll Vet Med, Dept Vet Pathobiol, Metagen Ctr, Columbia, MO 65201 USA.
   [Johnson, Philip J.; Bucy, Katie; Townsend, Kile S.; Martin, Lynn M.; LaCarrubba, Alison M.] Univ Missouri, Coll Vet Med, Dept Vet Med & Surg, Columbia, MO 65211 USA.
   [Gieche, Lyndsy M.; Zobrist, Chelsea] Univ Missouri, Coll Vet Med, Columbia, MO 65211 USA.
C3 University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia
RP Ericsson, AC (通讯作者)，Univ Missouri, Coll Vet Med, Dept Vet Pathobiol, Metagen Ctr, Columbia, MO 65201 USA.; Johnson, PJ (通讯作者)，Univ Missouri, Coll Vet Med, Dept Vet Med & Surg, Columbia, MO 65211 USA.
EM ericssona@missouri.edu; johnsonpj@missouri.edu; lgiechedvm@gmail.com;
   chelsea.zobrist@outlook.com; katie.bucy1@gmail.com;
   townsendks@missouri.edu; martinlyn@missouri.edu;
   lacarrubbaa@missouri.edu
RI Ericsson, Aaron C./AAJ-1406-2021
OI Ericsson, Aaron C./0000-0002-3053-7269; Townsend,
   Kile/0000-0001-8418-7842; Martin, Lynn/0000-0001-9731-8071
FU COR Clinician Scientist award; Phi Zeta award from the University of
   Missouri College of Veterinary Medicine, Columbia, MO; Boehringer
   Ingelheim (Veterinary Research Scholars Program); University of Missouri
   Metagenomics Center
FX This research was supported by a COR Clinician Scientist award and a Phi
   Zeta award from the University of Missouri College of Veterinary
   Medicine, Columbia, MO. Additional funding was made available for
   student training by Boehringer Ingelheim (Veterinary Research Scholars
   Program) and the University of Missouri Metagenomics Center.
CR [Anonymous], 1995, J R STAT SOC B
   Bokulich NA, 2018, MICROBIOME, V6, DOI 10.1186/s40168-018-0470-z
   Bolyen E, 2019, NAT BIOTECHNOL, V37, P852, DOI 10.1038/s41587-019-0209-9
   Callahan BJ, 2016, NAT METHODS, V13, P581, DOI [10.1038/NMETH.3869, 10.1038/nmeth.3869]
   Caporaso JG, 2011, P NATL ACAD SCI USA, V108, P4516, DOI 10.1073/pnas.1000080107
   Daly K, 2012, BRIT J NUTR, V107, P989, DOI 10.1017/S0007114511003825
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Durham AE, 2008, EQUINE VET J, V40, P493, DOI 10.2746/042516408X273648
   Durham AE, 2019, J VET INTERN MED, V33, P335, DOI 10.1111/jvim.15423
   Elzinga SE, 2016, J EQUINE VET SCI, V44, P9, DOI 10.1016/j.jevs.2016.05.010
   Ericsson AC, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0166523
   Fernandes KA, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0112846
   Frank N, 2010, J VET INTERN MED, V24, P467, DOI 10.1111/j.1939-1676.2010.0503.x
   Hammer Oyvind, 2001, Palaeontologia Electronica, V4, pUnpaginated
   Hugenholtz P, 1998, J BACTERIOL, V180, P4765, DOI 10.1128/JB.180.18.4765-4774.1998
   Hustace JL, 2009, AM J VET RES, V70, P665, DOI 10.2460/ajvr.70.5.665
   Johnson PJ, 2002, VET CLIN N AM-EQUINE, V18, P271, DOI 10.1016/S0749-0739(02)00006-8
   Kuczynski Justin, 2011, Curr Protoc Bioinformatics, VChapter 10, DOI [10.1002/9780471729259.mc01e05s27, 10.1002/0471250953.bi1007s36]
   Lee H, 2018, GUT MICROBES, V9, P155, DOI 10.1080/19490976.2017.1405209
   Loy A, 2007, NUCLEIC ACIDS RES, V35, pD800, DOI 10.1093/nar/gkl856
   Martin M., 2011, EMBNET J, V17, P10, DOI DOI 10.14806/EJ.17.1.200
   Morgan RA, 2014, AUST VET J, V92, P101, DOI 10.1111/avj.12159
   MUNO J, 2009, J VET INTERN MED, V23, P721
   Pleasant RS, 2013, J VET INTERN MED, V27, P576, DOI 10.1111/jvim.12056
   Quast C, 2013, NUCLEIC ACIDS RES, V41, pD590, DOI 10.1093/nar/gks1219
   Rendle DI, 2013, EQUINE VET J, V45, P751, DOI 10.1111/evj.12068
   Salem SE, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-26930-3
   Sessions-Bresnahan DR, 2014, J ANIM SCI, V92, P1484, DOI 10.2527/jas.2013-7275
   Shepherd ML, 2012, FEMS MICROBIOL LETT, V326, P62, DOI 10.1111/j.1574-6968.2011.02434.x
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Shu Y, 2007, J CLIN INVEST, V117, P1422, DOI 10.1172/JCI30558
   Smith S, 2016, EQUINE VET J, V48, P224, DOI 10.1111/evj.12413
   Spring S, 2016, ISME J, V10, P2801, DOI 10.1038/ismej.2016.84
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Tinworth KD, 2012, VET J, V191, P79, DOI 10.1016/j.tvjl.2011.01.015
   Tinworth KD, 2010, AM J VET RES, V71, P1201, DOI 10.2460/ajvr.71.10.1201
   Vick MM, 2006, REPROD FERT DEVELOP, V18, P609, DOI 10.1071/RD06016
   Walters WA, 2011, BIOINFORMATICS, V27, P1159, DOI 10.1093/bioinformatics/btr087
   Wang DS, 2002, J PHARMACOL EXP THER, V302, P510, DOI 10.1124/jpet.102.034140
   Willing B, 2009, EQUINE VET J, V41, P908, DOI 10.2746/042516409X447806
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Xia JG, 2009, NUCLEIC ACIDS RES, V37, pW652, DOI 10.1093/nar/gkp356
   Zhang X, 2015, SCI REP-UK, V5, DOI 10.1038/srep14405
NR 43
TC 5
Z9 5
U1 1
U2 12
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2076-2615
J9 ANIMALS-BASEL
JI Animals
PD APR
PY 2021
VL 11
IS 4
AR 976
DI 10.3390/ani11040976
PG 15
WC Agriculture, Dairy & Animal Science; Veterinary Sciences; Zoology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Veterinary Sciences; Zoology
GA RQ8GK
UT WOS:000642652000001
PM 33915682
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Wang, HL
   Chen, XH
   Chen, CH
   Pan, T
   Li, MY
   Yao, L
   Li, XF
   Lu, Q
   Wang, HF
   Wang, ZH
AF Wang, Haili
   Chen, Xinhua
   Chen, Chunhai
   Pan, Ting
   Li, Mengyuan
   Yao, Lin
   Li, Xuefeng
   Lu, Qi
   Wang, Hongfeng
   Wang, Zhaohui
TI Electroacupuncture at Lower He-Sea and Front-Mu Acupoints Ameliorates
   Insulin Resistance in Type 2 Diabetes Mellitus by Regulating the
   Intestinal Flora and Gut Barrier
SO DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
LA English
DT Article
DE type 2 diabetes mellitus; lower he -sea and front-mu acupoints; gut
   microbiota; gut barrier
ID MICROBIOTA; OBESITY; INTERLEUKIN-6; RATS
AB Introduction: The study objective was to investigate the effects of electroacupuncture performed at the he-sea and front-mu acupoints on the intestinal microflora and intestinal barrier in db/db mice and to explore the related mechanism in type 2 diabetes mellitus. Methods: Db/m mice in the normal control group (NOC), electroacupuncture group (EA), metformin group (MET) and T2DM group (T2DM) were used as model controls, and db/db mice were used in all three groups, with 8 mice in each group. The treatment period was 2 weeks. Fasting blood glucose (FBG) and triglyceride (TG) levels were measured. Lipopolysaccharide (LPS) and tumor necrosis factor-alpha (TNF-alpha) levels were detected by enzyme-linked immune sorbent assay (ELISA). The ileal tissue was stained with hematoxylin-eosin staining (H&E), and histopathological changes were observed under a light microscope. Illumina sequencing was used to analyze the V4 region of the 16S rRNA gene to evaluate the effect of EA on the intestinal flora.Results: Our results suggest that EA treatment can reduce the expression of diabetes-related markers, with an effect similar to that of metformin. After EA intervention, the abundance of Firmicutes and the ratio of Firmicutes to Bacteroidetes increased, while the abundances of Bacteroidetes and Eubacterium decreased. In addition, the serum levels of LPS and TNF-alpha in the electroacupuncture group were downregulated, and ileal tissue damage was alleviated under an electron microscope.Conclusion: EA combined with acupoints can restore the intestinal flora structure, decrease the blood LPS level, reduce levels of inflammation, maintain the integrity of the intestinal barrier, and play a therapeutic role in the treatment of T2DM, mainly by increasing the abundance of Firmicutes and the ratio of Firmicutes to Bacteroidetes and decreasing the abundances of Bacteroidetes and Eubacterium.
C1 [Wang, Haili; Pan, Ting; Li, Mengyuan; Yao, Lin; Li, Xuefeng; Lu, Qi; Wang, Zhaohui] Changchun Univ Chinese Med, Sch Acupuncture Moxibust & Tuina, Changchun 130117, Jilin, Peoples R China.
   [Chen, Xinhua; Chen, Chunhai] Affiliated Hosp Changchun Univ Chinese Med, Dept Acupuncture & Moxibust, Changchun 130021, Jilin, Peoples R China.
   [Wang, Hongfeng] Changchun Univ Chinese Med, Changchun 130117, Jilin, Peoples R China.
   [Wang, Zhaohui] Baoan Authent TCM Therapy Hosp, Shenzhen 518101, Peoples R China.
C3 Changchun University of Chinese Medicine; Changchun University of
   Chinese Medicine
RP Wang, ZH (通讯作者)，Changchun Univ Chinese Med, Sch Acupuncture Moxibust & Tuina, Changchun 130117, Jilin, Peoples R China.; Wang, HF (通讯作者)，Changchun Univ Chinese Med, Changchun 130117, Jilin, Peoples R China.
EM ccwhf@126.com; wzhqiwei@126.com
OI Yao, Lin/0000-0002-5948-2249; Wang, Haili/0000-0001-7741-6395
FU National Natural Science Funding of China [81774393]; Natural Science
   Foundation of Jilin Province [20200201612JC, 20210101191JC]
FX Acknowledgments We thank the National Natural Science Funding of China
   (81774393) , the Natural Science Foundation of Jilin Province
   (20200201612JC, 20210101191JC) .
CR Almuraikhy S, 2016, DIABETOLOGIA, V59, P2406, DOI 10.1007/s00125-016-4031-3
   Bender E, 2020, NATURE, V577, pS12, DOI 10.1038/d41586-020-00197-z
   Chen C, 2019, COMPLEMENT THER CLIN, V36, P100, DOI 10.1016/j.ctcp.2019.04.004
   Chen JJ, 2019, NEUROL RES, V41, P1104, DOI 10.1080/01616412.2019.1675021
   Cho NH, 2018, DIABETES RES CLIN PR, V138, P271, DOI 10.1016/j.diabres.2018.02.023
   Eckburg PB, 2005, SCIENCE, V308, P1635, DOI 10.1126/science.1110591
   Elkhidir Areej E, 2017, BMC Res Notes, V10, P285, DOI 10.1186/s13104-017-2604-y
   Fei N, 2013, ISME J, V7, P880, DOI 10.1038/ismej.2012.153
   Garibotto G, 2017, J NEPHROL, V30, P719, DOI 10.1007/s40620-017-0432-8
   Gilbert JA, 2018, NAT MED, V24, P392, DOI 10.1038/nm.4517
   Hiippala K, 2018, NUTRIENTS, V10, DOI 10.3390/nu10080988
   Huang JZ, 2021, BIOENGINEERED, V12, P11947, DOI 10.1080/21655979.2021.2009322
   Jia WK, 2021, FRONT CELL DEV BIOL, V9, DOI 10.3389/fcell.2021.634900
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Li K, 2019, FOOD FUNCT, V10, P1915, DOI 10.1039/c8fo02265h
   Li L, 2021, EVID-BASED COMPL ALT, V2021, DOI 10.1155/2021/8214052
   Liu ML, 2019, MEDICINE, V98, DOI 10.1097/MD.0000000000014059
   Liu SH, 2020, NEUROPSYCH DIS TREAT, V16, P859, DOI 10.2147/NDT.S243551
   Liu T, 2019, MBIO, V10, DOI 10.1128/mBio.02903-18
   Monguio-Tortajada M, 2018, CELL DEATH DIS, V9, DOI 10.1038/s41419-018-0520-2
   Nascimento JC, 2021, DIGEST DIS SCI, V66, P3359, DOI 10.1007/s10620-020-06664-x
   Oh JE, 2022, FRONT IMMUNOL, V12, DOI 10.3389/fimmu.2021.813748
   Patel TP, 2016, HEART FAIL REV, V21, P11, DOI 10.1007/s10741-015-9515-6
   Pearson ER, 2019, DIABETOLOGIA, V62, P1107, DOI 10.1007/s00125-019-4909-y
   Portincasa P, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23031105
   Rehman K, 2017, CRIT REV EUKAR GENE, V27, P229, DOI 10.1615/CritRevEukaryotGeneExpr.2017019712
   Roden M, 2019, NATURE, V576, P51, DOI 10.1038/s41586-019-1797-8
   Shin W, 2018, P NATL ACAD SCI USA, V115, pE10539, DOI 10.1073/pnas.1810819115
   Song JX, 2017, FRONT PHYSIOL, V8, DOI 10.3389/fphys.2017.00602
   Tremaroli V, 2012, NATURE, V489, P242, DOI 10.1038/nature11552
   Van Hul M, 2018, AM J PHYSIOL-ENDOC M, V314, pE334, DOI 10.1152/ajpendo.00107.2017
   Wang LL, 2020, LIFE SCI, V261, DOI 10.1016/j.lfs.2020.118473
   Wang X, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.655591
   Wang Zhao-Hui, 2014, Zhongguo Zhen Jiu, V34, P149
   Wu W, 2019, FASEB J, V33, P12616, DOI 10.1096/fj.201901061R
   Xu TC, 2022, MOL NEUROBIOL, V59, P703, DOI 10.1007/s12035-021-02609-1
   Yang M., 2017, CLIN STUDY EFFECT LO
   Yeh YC, 2021, EVID-BASED COMPL ALT, V2021, DOI 10.1155/2021/1943181
   Yu F, 2020, AGING-US, V12, P24156, DOI 10.18632/aging.104101
   Yuan JH, 2021, J DIABETES COMPLICAT, V35, DOI 10.1016/j.jdiacomp.2020.107766
   Zhang LY, 2021, DIABET METAB SYND OB, V14, P2595, DOI 10.2147/DMSO.S306861
   Zhang Q, 2020, DIABET METAB SYND OB, V13, P5003, DOI 10.2147/DMSO.S286430
   Zheng WJ, 2020, BIOMED PHARMACOTHER, V121, DOI 10.1016/j.biopha.2019.109564
NR 43
TC 0
Z9 0
U1 7
U2 12
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7007
J9 DIABET METAB SYND OB
JI Diabetes Metab. Syndr. Obes.
PY 2022
VL 15
BP 2265
EP 2276
DI 10.2147/DMSO.S374843
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 3M0KE
UT WOS:000835146000001
PM 35936053
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Hata, S
   Nakajima, H
   Hashimoto, Y
   Miyoshi, T
   Hosomi, Y
   Okamura, T
   Majima, S
   Nakanishi, N
   Senmaru, T
   Osaka, T
   Okada, H
   Ushigome, E
   Hamaguchi, M
   Asano, M
   Yamazaki, M
   Fukui, M
AF Hata, Shinnosuke
   Nakajima, Hanako
   Hashimoto, Yoshitaka
   Miyoshi, Tomoki
   Hosomi, Yukako
   Okamura, Takuro
   Majima, Saori
   Nakanishi, Naoko
   Senmaru, Takafumi
   Osaka, Takafumi
   Okada, Hiroshi
   Ushigome, Emi
   Hamaguchi, Masahide
   Asano, Mai
   Yamazaki, Masahiro
   Fukui, Michiaki
TI Effects of probiotic Bifidobacterium bifidum G9-1 on the
   gastrointestinal symptoms of patients with type 2 diabetes mellitus
   treated with metformin: An open-label, single-arm, exploratory research
   trial
SO JOURNAL OF DIABETES INVESTIGATION
LA English
DT Article
DE Constipation; Diarrhea; Probiotics
ID GUT MICROBIOME; SUPPLEMENTATION; METAGENOME; TRANSIT; FECES
AB Aims/Introduction Metformin is associated with the risk of gastrointestinal complications, and probiotic Bifidobacterium bifidum G9-1 (BBG9-1) can improve the symptoms of diarrhea. This study aimed to clarify the effects of probiotic BBG9-1 on the gastrointestinal symptoms of type 2 diabetes mellitus patients using metformin. Materials and methods In this open-label single-arm exploratory study, 40 patients (mean age 64.0 +/- 9.4 years) were given probiotic BBG9-1 for 10 weeks. Changes in the gastrointestinal symptom rating scale total score, which was the primary end-point, gastrointestinal symptom rating scale subscale scores, glycated hemoglobin levels and gut microbiota after the administration of probiotic BBG9-1 were evaluated by the Student's t-test. Results The gastrointestinal symptom rating scale total score significantly improved (from 2.02 +/- 0.51 to 1.59 +/- 0.43, change, -0.43 +/- 0.49, P < 0.001). Furthermore, all gastrointestinal symptom rating scale subscale scores, including diarrhea (from 2.32 +/- 1.14 to 1.89 +/- 0.99, change, -0.42 +/- 0.95, P = 0.007) and constipation (from 3.00 +/- 1.16 to 2.20 +/- 1.07, change, -0.80 +/- 1.19, P < 0.001), scores also significantly improved. However, the glycated hemoglobin levels did not change (from 7.0 +/- 0.7 to 7.0 +/- 0.6%, change, 0.0 +/- 0.4, P = 0.91). The relative abundance of the genus Sutterella decreased by the use of probiotic BBG9-1 (from 0.011 +/- 0.009 to 0.008 +/- 0.006, change, -0.003 +/- 0.006, P = 0.002). Conclusions Type 2 diabetes mellitus patients treated with metformin showed significant improvement in all gastrointestinal symptom rating scores after using probiotic BBG9-1 without changing the glucose control. This study showed the potential usefulness of probiotic BBG9-1 for improving gastrointestinal symptoms, including constipation and diarrhea, in type 2 diabetes mellitus patients treated with metformin.
C1 [Hata, Shinnosuke; Nakajima, Hanako; Hashimoto, Yoshitaka; Miyoshi, Tomoki; Hosomi, Yukako; Okamura, Takuro; Majima, Saori; Nakanishi, Naoko; Senmaru, Takafumi; Osaka, Takafumi; Okada, Hiroshi; Ushigome, Emi; Hamaguchi, Masahide; Asano, Mai; Yamazaki, Masahiro; Fukui, Michiaki] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Endocrinol & Metab, Kyoto, Japan.
C3 Kyoto Prefectural University of Medicine
RP Hashimoto, Y (通讯作者)，Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Endocrinol & Metab, Kyoto, Japan.
EM y-hashi@koto.kpu-m.ac.jp
RI Hashimoto, Yoshitaka/AAH-8503-2020
OI Hashimoto, Yoshitaka/0000-0002-8794-0550; Okamura,
   Takuro/0000-0001-7269-1697
FU Biofermin Pharmaceutical. Co. Ltd.
FX The authors thank all the clinical staff for their assistance with the
   execution of the clinical trial, and Soiken Inc. for their technical
   assistance in the launch and execution of the trial. The authors thank
   Editage (www.editage.com) for English language editing. This study,
   including the article processing charge, was funded by Biofermin
   Pharmaceutical. Co. Ltd. No drugs were donated or funded by the sponsor.
   No funding bodies had any role in the study design, data collection and
   analysis, decision to publish or preparation of the manuscript.
CR Agrawal A, 2009, ALIMENT PHARM THER, V29, P104, DOI 10.1111/j.1365-2036.2008.03853.x
   Benach JL, 2012, MBIO, V3, DOI 10.1128/mBio.00019-12
   Blandino G, 2016, DIABETES METAB, V42, P303, DOI 10.1016/j.diabet.2016.04.004
   Bolyen E, 2019, NAT BIOTECHNOL, V37, P852, DOI 10.1038/s41587-019-0209-9
   Brunkwall L, 2017, DIABETOLOGIA, V60, P943, DOI 10.1007/s00125-017-4278-3
   Callahan BJ, 2016, NAT METHODS, V13, P581, DOI [10.1038/NMETH.3869, 10.1038/nmeth.3869]
   Chatterjee S, 2017, LANCET, V389, P2239, DOI 10.1016/S0140-6736(17)30058-2
   Cox AJ, 2019, ASIA PAC J CLIN NUTR, V28, P734, DOI 10.6133/apjcn.201912_28(4).0009
   Culpepper T, 2016, BENEF MICROBES, V7, P327, DOI 10.3920/BM2015.0156
   DIMENAS E, 1995, SCAND J GASTROENTERO, V30, P1046, DOI 10.3109/00365529509101605
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Francavilla R, 2019, J CLIN GASTROENTEROL, V53, pE117, DOI 10.1097/MCG.0000000000001023
   Hashimoto Y, 2020, J CLIN BIOCHEM NUTR, V67, P223, DOI 10.3164/jcbn.20-100
   Hashimoto Y, 2020, J DIABETES INVEST, V11, P1623, DOI 10.1111/jdi.13293
   Hiippala K, 2016, FRONT MICROBIOL, V7, DOI 10.3389/fmicb.2016.01706
   Hills RD, 2019, NUTRIENTS, V11, DOI 10.3390/nu11071613
   Hung WW, 2021, DIABETES RES CLIN PR, V174, DOI 10.1016/j.diabres.2021.108731
   Ibarra A, 2018, GUT MICROBES, V9, P236, DOI 10.1080/19490976.2017.1412908
   Ishizuka A, 2012, J BIOSCI BIOENG, V113, P587, DOI 10.1016/j.jbiosc.2011.12.016
   Kalman DS, 2009, BMC GASTROENTEROL, V9, DOI 10.1186/1471-230X-9-85
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Leeds JS, 2018, BMJ OPEN DIAB RES CA, V6, DOI 10.1136/bmjdrc-2018-000514
   Maisey A, 2016, DIABETES THER, V7, P379, DOI 10.1007/s13300-016-0182-y
   Makizaki Y, 2020, BIOSCI MICROB FOOD H, V39, P145, DOI 10.12938/bmfh.2019-022
   Mangin I, 2004, FEMS MICROBIOL ECOL, V50, P25, DOI 10.1016/j.femsec.2004.05.005
   McCreight LJ, 2018, DIABETES OBES METAB, V20, P1593, DOI 10.1111/dom.13264
   Ministry of Health Labor and Welfare in Japan, 2016, NAT HLTH NUTR EX SUR
   Nakajima H, 2020, LIFE-BASEL, V10, DOI 10.3390/life10090195
   Peters B, 2014, J AUTISM DEV DISORD, V44, P1425, DOI 10.1007/s10803-013-2009-2
   Piper Marc S, 2017, Curr Treat Options Gastroenterol, V15, P460, DOI 10.1007/s11938-017-0151-1
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Quan C, 2008, EUR J GASTROEN HEPAT, V20, P888, DOI 10.1097/MEG.0b013e3282f5f734
   Sanchez-Rangel E, 2017, DIABETOLOGIA, V60, P1586, DOI 10.1007/s00125-017-4336-x
   Santoru ML, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-10034-5
   Singh RK, 2017, J TRANSL MED, V15, DOI 10.1186/s12967-017-1175-y
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Zawada AE, 2018, ADV CLIN EXP MED, V27, P567, DOI 10.17219/acem/67961
NR 37
TC 5
Z9 5
U1 1
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2040-1116
EI 2040-1124
J9 J DIABETES INVEST
JI J. Diabetes Investig.
PD MAR
PY 2022
VL 13
IS 3
BP 489
EP 500
DI 10.1111/jdi.13698
EA NOV 2021
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA ZO4QX
UT WOS:000718273500001
PM 34665938
OA Green Published
DA 2023-06-08
ER

PT J
AU Bornstein, S
   Moschetta, M
   Kawano, Y
   Sacco, A
   Huynh, D
   Brooks, D
   Manier, S
   Fairfield, H
   Falank, C
   Roccaro, AM
   Nagano, K
   Baron, R
   Bouxein, M
   Vary, C
   Ghobrial, IM
   Rosen, CJ
   Reagan, MR
AF Bornstein, Sheila
   Moschetta, Michele
   Kawano, Yawara
   Sacco, Antonio
   Huynh, Daisy
   Brooks, Daniel
   Manier, Salomon
   Fairfield, Heather
   Falank, Carolyne
   Roccaro, Aldo M.
   Nagano, Kenichi
   Baron, Roland
   Bouxein, Mary
   Vary, Calvin
   Ghobrial, Irene M.
   Rosen, Clifford J.
   Reagan, Michaela R.
TI Metformin Affects Cortical Bone Mass and Marrow Adiposity in
   Diet-Induced Obesity in Male Mice
SO ENDOCRINOLOGY
LA English
DT Article
ID MINERAL DENSITY; INSULIN-RESISTANCE; IN-VIVO; TISSUE; WOMEN; WEIGHT;
   MICROARCHITECTURE; MICROSTRUCTURE; STRENGTH; MYELOMA
AB Obesity during maturation can affect the growing skeleton directly and indirectly, although these effects and the mechanisms behind them are not fully understood. Our objective was to determine how a high-fat diet with or without metformin treatment affects skeletal development. We also sought to characterize changes that occur in white adipose tissue, circulating metabolites, lipids, and gut microbiota. A diet-induced obesity C57BL/6J mouse model was used to test the effects of obesity and metformin on bone using bone histomorphometry and microcomputed tomography. Bone marrow adipose tissue was quantified with osmium tetroxide microcomputed tomography and histology. Dual-energy x-ray absorptiometry was used to analyze body composition. Hematoxylin and eosin staining was used to assess changes in white adipose depots, mass spectrometry was used for circulating lipids and protein metabolite analysis, and ribosomal RNA sequencing was used for gut microbiome analysis. Mice fed a high fat-diet since wean displayed increased medullary areas and decreased osteoblast numbers in the long bones; this phenotype was partially normalized by metformin. Marrow and inguinal adipose expansion was also noted in obese mice, and this was partially normalized by metformin. A drug-by-diet interaction was noted for circulating lipid molecules, protein metabolites, and gut microbiome taxonomical units. Obesity was not detrimental to trabecular bone in growing mice, but bone marrow medullary expansion was observed, likely resulting from inhibition of osteoblastogenesis, and this was partially reversed by metformin treatment.
C1 [Bornstein, Sheila; Fairfield, Heather; Falank, Carolyne; Vary, Calvin; Rosen, Clifford J.; Reagan, Michaela R.] Maine Med Ctr, Res Inst, 81 Res Dr, Scarborough, ME 04074 USA.
   [Moschetta, Michele; Kawano, Yawara; Sacco, Antonio; Huynh, Daisy; Manier, Salomon; Roccaro, Aldo M.; Reagan, Michaela R.] Dana Farber Canc Inst, Boston, MA 02115 USA.
   [Sacco, Antonio; Roccaro, Aldo M.] Azienda Socio Sanitaria Territoriale Spedali Civi, Progettaz Ric Clin & Studi Fase 1, Lab Ctr Ric OncoEmatol AIL, Brescia, BS, Italy.
   [Brooks, Daniel; Bouxein, Mary] Beth Israel Deaconess Med Ctr, Boston, MA 02115 USA.
   [Brooks, Daniel; Bouxein, Mary] Massachusetts Gen Hosp, Skeletal Res Ctr, Boston, MA 02114 USA.
   [Fairfield, Heather; Falank, Carolyne; Vary, Calvin; Rosen, Clifford J.; Reagan, Michaela R.] Univ Maine, Grad Sch Biomed Sci & Engn, Orono, ME 04469 USA.
   [Fairfield, Heather; Falank, Carolyne; Vary, Calvin; Rosen, Clifford J.; Reagan, Michaela R.] Tufts Univ, Sch Med, Boston, MA 02215 USA.
   [Nagano, Kenichi; Baron, Roland] Harvard Med Sch, Harvard Sch Dent Med, Dept Oral Med Infect & Immun, Boston, MA 02115 USA.
C3 Maine Medical Center; Harvard University; Dana-Farber Cancer Institute;
   Harvard University; Beth Israel Deaconess Medical Center; Harvard
   University; Massachusetts General Hospital; University of Maine System;
   University of Maine Orono; Tufts University; Harvard University; Harvard
   Medical School; Harvard School of Dental Medicine
RP Reagan, MR (通讯作者)，Maine Med Ctr, Res Inst, 81 Res Dr, Scarborough, ME 04074 USA.
EM Mreagan@mmc.org
RI Sacco, Antonio/AFL-7734-2022; Kawano, Yawara/AAH-8714-2020; Sacco,
   Antonio/AAG-7676-2022; Dimopoulos, Meletios Athanasios/AAD-4130-2019;
   Nagano, Kenichi/AAH-3246-2019; Sacco, Antonio/K-4681-2016
OI Kawano, Yawara/0000-0002-8269-440X; Nagano, Kenichi/0000-0003-3145-4841;
   Reagan, Michaela/0000-0003-2884-6481; Sacco, Antonio/0000-0003-2945-9416
FU Center for Skeletal Research Core [National Institutes of Health (NIH)]
   [P30 AR066261]; National Institute of General Medical Sciences
   (NIGMS)/NIH [P30 GM106391]; Histopathology Core of NIH Grants NIGMS [P30
   GM103392, P30GM106391]; Maine Medical Center Research Institute;
   NIH/National Institute of Diabetes and Digestive and Kidney Diseases
   [R24 DK092759-01]; American Cancer Society [IRG-16-191-33]
FX This work was supported by funding from the Center for Skeletal Research
   Core [National Institutes of Health (NIH) Grant P30 AR066261], the
   National Institute of General Medical Sciences (NIGMS)/NIH Grant P30
   GM106391, the Histopathology Core of NIH Grants NIGMS P30 GM103392 (R.
   Friesel, principal investigator) and P30GM106391 (D. Wojchowski,
   principal investigator), startup funds from the Maine Medical Center
   Research Institute, the NIH/National Institute of Diabetes and Digestive
   and Kidney Diseases (Grant R24 DK092759-01), and the American Cancer
   Society (Research Grant IRG-16-191-33).
CR Barbato DL, 2013, CELL DEATH DIS, V4, DOI 10.1038/cddis.2013.404
   Bouxsein ML, 2010, J BONE MINER RES, V25, P1468, DOI 10.1002/jbmr.141
   Bredella MA, 2012, J CLIN ENDOCR METAB, V97, P4115, DOI 10.1210/jc.2012-2246
   Chan KA, 2000, LANCET, V355, P2185, DOI 10.1016/S0140-6736(00)02400-4
   Chandel NS, 2016, CELL METAB, V23, P569, DOI 10.1016/j.cmet.2016.03.010
   Chandran M, 2017, CALCIFIED TISSUE INT, V100, P133, DOI 10.1007/s00223-016-0203-x
   Chen X, 2016, BONE, V93, P104, DOI 10.1016/j.bone.2016.09.016
   Delahunty KM, 2006, ENDOCRINOLOGY, V147, P3915, DOI 10.1210/en.2006-0277
   Dempster DW, 2013, J BONE MINER RES, V28, P1, DOI 10.1002/jbmr.1805
   Doucette CR, 2015, J CELL PHYSIOL, V230, P2032, DOI 10.1002/jcp.24954
   Ducy P, 2000, CELL, V100, P197, DOI 10.1016/S0092-8674(00)81558-5
   Evans AL, 2015, J BONE MINER RES, V30, P920, DOI 10.1002/jbmr.2407
   Fan Y, 2017, CELL METAB, V25, P661, DOI 10.1016/j.cmet.2017.01.001
   Fu R, 2016, ANN HEMATOL, V95, P1099, DOI 10.1007/s00277-016-2657-3
   Hu CC, 2004, OBES RES, V12, P1264, DOI 10.1038/oby.2004.160
   Jang WG, 2011, BIOCHEM BIOPH RES CO, V404, P1004, DOI 10.1016/j.bbrc.2010.12.099
   Kim EK, 2016, MEDIAT INFLAMM, V2016, P1, DOI DOI 10.1155/2016/5813030
   Liaw L, 2016, J CELL BIOCHEM, V117, P2182, DOI 10.1002/jcb.25522
   Luo B, 2007, J CHROMATOGR A, V1147, P153, DOI 10.1016/j.chroma.2007.02.034
   Luo T, 2016, DIABETES, V65, P2295, DOI 10.2337/db15-1122
   Lupattelli G, 2004, METABOLISM, V53, P744, DOI 10.1016/j.metabol.2004.01.010
   Lutz TA, 2012, CURR PROTOC PHARM, V61, P1
   Fernandez JM, 2013, EUR J PHARMACOL, V706, P41, DOI 10.1016/j.ejphar.2013.02.042
   Mao Y, 2013, CHINESE MED J-PEKING, V126, P3717, DOI 10.3760/cma.j.issn.0366-6999.20122806
   McCreight LJ, 2016, DIABETOLOGIA, V59, P426, DOI 10.1007/s00125-015-3844-9
   Morin S, 2009, OSTEOPOROSIS INT, V20, P363, DOI 10.1007/s00198-008-0688-x
   Neglia C, 2016, INT J ENV RES PUB HE, V13, DOI 10.3390/ijerph13111067
   Pernicova I, 2014, NAT REV ENDOCRINOL, V10, P143, DOI 10.1038/nrendo.2013.256
   Ramos ES, 2017, J BONE MINER RES, V32, P974, DOI 10.1002/jbmr.3072
   Riserus U, 2009, PROG LIPID RES, V48, P44, DOI 10.1016/j.plipres.2008.10.002
   Samelson EJ, 2004, BONE, V34, P557, DOI 10.1016/j.bone.2003.11.024
   Scheller EL, 2014, METHOD ENZYMOL, V537, P123, DOI 10.1016/B978-0-12-411619-1.00007-0
   Shu L, 2015, CALCIFIED TISSUE INT, V96, P313, DOI 10.1007/s00223-015-9954-z
   Molinuevo MS, 2010, J BONE MINER RES, V25, P211, DOI 10.1359/jbmr.090732
   Simons B, 2012, METABOLITES, V2, P195, DOI 10.3390/metabo2010195
   Solomon Daniel H, 2005, Am J Med, V118, P1414, DOI 10.1016/j.amjmed.2005.07.031
   Sornay-Rendu E, 2013, J BONE MINER RES, V28, P1679, DOI 10.1002/jbmr.1880
   Souza-Mello V, 2010, CLIN SCI, V119, P239, DOI 10.1042/CS20100061
   Swami A, 2014, P NATL ACAD SCI USA, V111, P10287, DOI 10.1073/pnas.1401337111
   Wang FN, 2010, BIOCHEM J, V425, P71, DOI 10.1042/BJ20090928
   Wanninger J, 2008, BBA-MOL CELL BIOL L, V1781, P321, DOI 10.1016/j.bbalip.2008.04.012
   Woo SL, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0091111
   Yu EW, 2017, BONE, V97, P38, DOI 10.1016/j.bone.2016.12.018
   Yue R, 2016, CELL STEM CELL, V18, P782, DOI 10.1016/j.stem.2016.02.015
   Zhao JX, 2010, BIOCHEM BIOPH RES CO, V395, P146, DOI 10.1016/j.bbrc.2010.03.161
NR 45
TC 43
Z9 43
U1 1
U2 17
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0013-7227
EI 1945-7170
J9 ENDOCRINOLOGY
JI Endocrinology
PD OCT
PY 2017
VL 158
IS 10
BP 3369
EP 3385
DI 10.1210/en.2017-00299
PG 17
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA FI9BO
UT WOS:000412298700028
PM 28977604
OA Green Published, Bronze
DA 2023-06-08
ER

PT J
AU Maulidiani, M
   Abas, F
   Rudiyanto, R
   Abd Kadir, NH
   Zolkeflee, NKZ
   Lajise, NH
AF Maulidiani, M.
   Abas, Faridah
   Rudiyanto, R.
   Abd Kadir, Nurul Huda
   Zolkeflee, Nur Khaleeda. Zulaikha
   Lajise, Nordin H.
TI Analysis of urinary metabolic alteration in type 2 diabetic rats treated
   with metformin using the metabolomics of quantitative spectral
   deconvolution H-1 NMR spectroscopy
SO MICROCHEMICAL JOURNAL
LA English
DT Article; Proceedings Paper
CT 19th Brazilian Meeting on Analytical Chemistry / 7th Iberoamerican
   Congress on Analytical Chemistry
CY SEP 16-19, 2018
CL Caldas Novas, BRAZIL
SP Brazilian Chem Soc, Anal Chem Div
DE Metformin; Type 2 diabetic rat model; Urine metabolites; Deconvolution
   method; Quantitative 1H NMR-based metabolomics
ID HYPERGLYCEMIA; METAANALYSIS; MELLITUS
AB Metformin has been used clinically as the first-choice drug to treat type 2 diabetes patients. It is not metabolized in liver and the residue which is excreted unchanged in the urine. Identification and quantification of metformin in the urine can be used as a unique marker for the metformin treated diabetic patients. The aim of our study was to identify residual metformin in the urine of type 2 diabetic rats using quantitative spectral deconvolution of H-1 NMR method. Additionally, quantitative assessment of residual metformin and other identified metabolites in the urine, as well as the evaluation of metabolic alteration due to metformin treatment of diabetic condition were also carried out. Partial least square discriminant analysis (PLS-DA) and statistical analysis were used to discriminate the metformin treated type 2 diabetic, the lean, the obese, and the type 2 diabetic rat groups. Furthermore, in order to evaluate the statistical difference of metabolite levels between the groups, ANOVA test was performed. The presence of metformin in the urine of the metformin treated diabetic rats from the H-1 NMR spectral analysis and its identity was confirmed by 2D NMR spectroscopy experiments including the 2D H-1 J-resolved (JRES), and H-1 heteronuclear multiple correlation (HMBC). Based on the PLS-DA model and statistical analysis, it was established that metformin treatment significantly influenced the improvement of glucose and 1-methylnicotinamide metabolism; increase the growth and activity of gut microbiota as indicated by the elevation of trimethylamine (TMA), phenylacetylglycine (PAG) and indoxylsulfate levels; as well as the suppression of tricarboxylic acid (TCA) cycle metabolism as shown by the decreased levels of citrate, 2-oxoglutarate, succinate, and fumarate. This study provided new approach to the quantitative analysis of metformin in urine and further exploration on the effect of metformin treatment on the type 2 diabetic rats revealed useful findings on its metabolic states.
C1 [Maulidiani, M.; Abd Kadir, Nurul Huda] Univ Malaysia Terengganu, Fac Sci & Marine Environm, Terengganu 21030, Malaysia.
   [Maulidiani, M.; Abas, Faridah; Zolkeflee, Nur Khaleeda. Zulaikha] Univ Putra Malaysia, Inst Biosci, Lab Nat Prod, Serdang 43400, Selangor, Malaysia.
   [Abas, Faridah] Univ Putra Malaysia, Fac Food Sci & Technol, Dept Food Sci, Serdang 43400, Selangor, Malaysia.
   [Rudiyanto, R.] Univ Malaysia Terengganu, Fac Fisheries & Food Sci, Terengganu 21030, Malaysia.
   [Lajise, Nordin H.] Univ Putra Malaysia, Fac Sci, Dept Chem, Upm Serdang 43400, Selangor, Malaysia.
C3 Universiti Malaysia Terengganu; Universiti Putra Malaysia; Universiti
   Putra Malaysia; Universiti Malaysia Terengganu; Universiti Putra
   Malaysia
RP Maulidiani, M (通讯作者)，Univ Malaysia Terengganu, Fac Sci & Marine Environm, Terengganu 21030, Malaysia.; Abas, F (通讯作者)，Univ Putra Malaysia, Fac Food Sci & Technol, Dept Food Sci, Serdang 43400, Selangor, Malaysia.
EM maulidiani@umt.edu.my; faridah_abas@upm.edu.my
RI Kadir, Nurul Huda Abd/B-6775-2015; , Maulidiani/B-3053-2019; ,
   Rudiyanto/AAC-8364-2019; Abas, Faridah/B-9229-2015
OI Kadir, Nurul Huda Abd/0000-0002-3263-9568; ,
   Maulidiani/0000-0002-3227-4191; , Rudiyanto/0000-0002-8837-8053; Abas,
   Faridah/0000-0002-8110-9424
FU Ministry of Higher Education Malaysia [02-10-10-967FR]
FX We would like to thank the Ministry of Higher Education Malaysia for the
   financial support under Fundamental Research Grant Scheme (project no.
   02-10-10-967FR).
CR Campbell RK, 1996, CLIN THER, V18, P360, DOI 10.1016/S0149-2918(96)80017-8
   Dona AC, 2016, COMPUT STRUCT BIOTEC, V14, P135, DOI 10.1016/j.csbj.2016.02.005
   Dong Y, 2016, MOLECULES, V21, DOI 10.3390/molecules21111446
   Duong JK, 2012, DIABETES OBES METAB, V14, P963, DOI 10.1111/j.1463-1326.2012.01617.x
   Emwas Abdul-Hamid M, 2015, Methods Mol Biol, V1277, P161, DOI 10.1007/978-1-4939-2377-9_13
   Graham GG, 2011, CLIN PHARMACOKINET, V50, P81, DOI 10.2165/11534750-000000000-00000
   Griffin SJ, 2017, DIABETOLOGIA, V60, P1620, DOI 10.1007/s00125-017-4337-9
   Hao J, 2014, NAT PROTOC, V9, P1416, DOI 10.1038/nprot.2014.090
   Hardie DG, 2007, ANNU REV PHARMACOL, V47, P185, DOI 10.1146/annurev.pharmtox.47.120505.105304
   Huo TG, 2009, J PHARMACEUT BIOMED, V49, P976, DOI 10.1016/j.jpba.2009.01.008
   Inzucchi SE, 2015, DIABETES CARE, V38, P140, DOI 10.2337/dc14-2441
   Jalil AMM, 2008, J AGR FOOD CHEM, V56, P7877, DOI 10.1021/jf8015915
   Kanehisa M, 2000, NUCLEIC ACIDS RES, V28, P27, DOI 10.1093/nar/28.1.27
   Lamanna C, 2011, DIABETES OBES METAB, V13, P221, DOI 10.1111/j.1463-1326.2010.01349.x
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Liu J, 2010, DIABETES-METAB RES, V26, P448, DOI 10.1002/dmrr.1101
   Martin F.-.P., 2016, Patent No. 9523671B2
   Maulidiani, 2019, ANAL METHODS-UK, V11, P5487, DOI 10.1039/c9ay00594c
   Maulidiani, 2017, METABOLOMICS, V13, DOI 10.1007/s11306-017-1273-0
   Maulidiani, 2016, J ETHNOPHARMACOL, V180, P60, DOI 10.1016/j.jep.2016.01.001
   Pelantova H, 2016, MOL CELL ENDOCRINOL, V431, P88, DOI 10.1016/j.mce.2016.05.003
   Salek RM, 2007, PHYSIOL GENOMICS, V29, P99, DOI 10.1152/physiolgenomics.00194.2006
   Tang WHW, 2014, J CLIN INVEST, V124, P4204, DOI 10.1172/JCI72331
   Weljie AM, 2006, ANAL CHEM, V78, P4430, DOI 10.1021/ac060209g
   Wishart DS, 2013, NUCLEIC ACIDS RES, V41, pD801, DOI 10.1093/nar/gks1065
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
NR 26
TC 8
Z9 8
U1 1
U2 20
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0026-265X
EI 1095-9149
J9 MICROCHEM J
JI Microchem J.
PD MAR
PY 2020
VL 153
AR 104513
DI 10.1016/j.microc.2019.104513
PG 10
WC Chemistry, Analytical
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Chemistry
GA KM5ZR
UT WOS:000514218800095
OA Green Accepted
DA 2023-06-08
ER

PT J
AU Kuka, J
   Videja, M
   Makrecka-Kuka, M
   Liepins, J
   Grinberga, S
   Sevostjanovs, E
   Vilks, K
   Liepinsh, E
   Dambrova, M
AF Kuka, Janis
   Videja, Melita
   Makrecka-Kuka, Marina
   Liepins, Janis
   Grinberga, Solveiga
   Sevostjanovs, Eduards
   Vilks, Karlis
   Liepinsh, Edgars
   Dambrova, Maija
TI Metformin decreases bacterial trimethylamine production and
   trimethylamine N-oxide levels in db/db mice
SO SCIENTIFIC REPORTS
LA English
DT Article
ID L-CARNITINE; INTESTINAL MICROBIOTA; GAMMA-BUTYROBETAINE; GUT MICROBIOTA;
   METABOLISM; CHOLINE; PHOSPHATIDYLCHOLINE; METAGENOME; ALTERS; SERUM
AB The current study aimed to explore whether metformin, the most widely prescribed oral medication for the treatment of type 2 diabetes, alters plasma levels of cardiometabolic disease-related metabolite trimethylamine N-oxide (TMAO) in db/db mice with type 2 diabetes. TMAO plasma concentration was up to 13.2-fold higher in db/db mice when compared to control mice, while in db/db mice fed choline-enriched diet, that mimics meat and dairy product intake, TMAO plasma level was increased 16.8-times. Metformin (250 mg/kg/day) significantly decreased TMAO concentration by up to twofold in both standard and choline-supplemented diet-fed db/db mice plasma. In vitro, metformin significantly decreased the bacterial production rate of trimethylamine (TMA), the precursor of TMAO, from choline up to 3.25-fold in K. pneumoniae and up to 26-fold in P. Mirabilis, while significantly slowing the growth of P. Mirabilis only. Metformin did not affect the expression of genes encoding subunits of bacterial choline-TMA-lyase microcompartment, the activity of the enzyme itself and choline uptake, suggesting that more complex regulation beyond the choline-TMA-lyase is present. To conclude, the TMAO decreasing effect of metformin could be an additional mechanism behind the clinically observed cardiovascular benefits of the drug.
C1 [Kuka, Janis; Videja, Melita; Makrecka-Kuka, Marina; Grinberga, Solveiga; Sevostjanovs, Eduards; Vilks, Karlis; Liepinsh, Edgars; Dambrova, Maija] Latvian Inst Organ Synth, Aizkraukles Str 21, LV-1006 Riga, Latvia.
   [Videja, Melita; Dambrova, Maija] Riga Stradins Univ, Fac Pharm, Dzirciema Str 16, LV-1007 Riga, Latvia.
   [Liepins, Janis] Univ Latvia, Inst Microbiol & Biotechnol, Jelgavas Str 1, LV-1004 Riga, Latvia.
C3 Latvian Institute of Organic Synthesis; Riga Stradins University; Riga
   Stradins University; University of Latvia
RP Kuka, J (通讯作者)，Latvian Inst Organ Synth, Aizkraukles Str 21, LV-1006 Riga, Latvia.
EM janis.kuka@farm.osi.lv
OI Vilks, Karlis/0000-0002-4203-2129; Kuka, Janis/0000-0002-0411-0229;
   Liepinsh, Edgars/0000-0003-2213-8337; Dambrova,
   Maija/0000-0002-1739-0928; Ozola, Melita/0000-0002-3453-0099
FU Latvian Council of Science project "Trimethylamine-N-oxide as a link
   between unhealthy diet and cardiometabolic risks" [Izp-2018/1-0081]
FX This study was funded by the Latvian Council of Science project
   "Trimethylamine-N-oxide as a link between unhealthy diet and
   cardiometabolic risks" No. Izp-2018/1-0081, project supervised by M.D.
CR Al-Obaide MAI, 2017, J CLIN MED, V6, DOI 10.3390/jcm6090086
   Bailey CJ, 2008, DIABETOLOGIA, V51, P1552, DOI 10.1007/s00125-008-1053-5
   Bauer PV, 2018, CELL METAB, V27, P101, DOI 10.1016/j.cmet.2017.09.019
   Beli E, 2019, NUTRIENTS, V11, DOI 10.3390/nu11102310
   Chen SF, 2019, CELL METAB, V30, P1141, DOI 10.1016/j.cmet.2019.08.021
   Chou RH, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-40638-y
   Craciun S, 2014, ACS CHEM BIOL, V9, P1408, DOI 10.1021/cb500113p
   Dambrova M, 2016, EXP CLIN ENDOCR DIAB, V124, P251, DOI 10.1055/s-0035-1569330
   Dambrova M, 2013, J CLIN PHARMACOL, V53, P1095, DOI 10.1002/jcph.135
   Eskens BJM, 2013, CARDIOVASC DIABETOL, V12, DOI 10.1186/1475-2840-12-175
   Ferrand J, 2014, J MICROBIOL METH, V105, P180, DOI 10.1016/j.mimet.2014.07.029
   Flory JH, 2018, BMJ OPEN, V8, DOI 10.1136/bmjopen-2018-021505
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Han YC, 2019, CARDIOVASC DIABETOL, V18, DOI 10.1186/s12933-019-0900-7
   Herring TI, 2018, J BACTERIOL, V200, DOI 10.1128/JB.00764-17
   Huo TG, 2009, J PHARMACEUT BIOMED, V49, P976, DOI 10.1016/j.jpba.2009.01.008
   Kalnins G, 2015, J BIOL CHEM, V290, P21732, DOI 10.1074/jbc.M115.670471
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kilkenny C, 2010, J GENE MED, V12, P561, DOI [10.1111/j.1476-5381.2010.00872.x, 10.1002/jgm.1473, 10.1113/jphysiol.2010.192278]
   Koeth RA, 2014, CELL METAB, V20, P799, DOI 10.1016/j.cmet.2014.10.006
   Koeth RA, 2013, NAT MED, V19, P576, DOI 10.1038/nm.3145
   Kuka J, 2014, LIFE SCI, V117, P84, DOI 10.1016/j.lfs.2014.09.028
   Latkovskis G, 2018, BRIT J CLIN PHARMACO, V84, P2634, DOI 10.1111/bcp.13728
   Lee H, 2018, GERONTOLOGIST, V58, P159, DOI 10.1093/geront/gnx050
   Lever M, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0114969
   Li TJ, 2017, FRONT PHYSIOL, V8, DOI 10.3389/fphys.2017.00350
   Liepinsh E, 2016, PHARMACOL RES, V113, P788, DOI 10.1016/j.phrs.2015.11.014
   Luo F, 2019, CARDIOVASC DIABETOL, V18, DOI 10.1186/s12933-019-0860-y
   Madiraju AK, 2014, NATURE, V510, P542, DOI 10.1038/nature13270
   Martinez-del Campo A, 2015, MBIO, V6, DOI 10.1128/mBio.00042-15
   McCreight LJ, 2016, DIABETOLOGIA, V59, P426, DOI 10.1007/s00125-015-3844-9
   McGrath JC, 2010, BRIT J PHARMACOL, V160, P1573, DOI 10.1111/j.1476-5381.2010.00873.x
   Miao J, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms7498
   Nafisa A, 2018, PHARMACOL THERAPEUT, V192, P150, DOI 10.1016/j.pharmthera.2018.07.007
   Proctor WR, 2008, DRUG METAB DISPOS, V36, P1650, DOI 10.1124/dmd.107.020180
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Roberts AB, 2018, NAT MED, V24, P1407, DOI 10.1038/s41591-018-0128-1
   Rose Randy L, 2002, Curr Protoc Toxicol, VChapter 4, DOI 10.1002/0471140856.tx0409s13
   Sack JS, 2008, ACTA CRYSTALLOGR D, V64, P705, DOI 10.1107/S0907444908010032
   Sardu C, 2019, DIABETES CARE, V42, P1946, DOI 10.2337/dc18-2356
   SEIM H, 1982, FEMS MICROBIOL LETT, V13, P201
   Shishavan MH, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-11430-7
   Stynen B, 2018, CELL, V175, P1418, DOI 10.1016/j.cell.2018.09.050
   Tang WHW, 2013, NEW ENGL J MED, V368, P1575, DOI 10.1056/NEJMoa1109400
   Velebova K, 2016, DIABETOLOGIA, V59, pS533
   Wang ZN, 2011, NATURE, V472, P57, DOI 10.1038/nature09922
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Wu WK, 2019, GUT, V68, P1439, DOI 10.1136/gutjnl-2018-317155
   Ye J, 2012, BMC BIOINFORMATICS, V13, DOI 10.1186/1471-2105-13-134
NR 49
TC 15
Z9 15
U1 1
U2 5
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD SEP 3
PY 2020
VL 10
IS 1
AR 14555
DI 10.1038/s41598-020-71470-4
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA NR0BM
UT WOS:000571229700047
PM 32884086
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Wang, JH
   Bose, S
   Lim, SK
   Ansari, A
   Chin, YW
   Choi, HS
   Kim, H
AF Wang, Jing-Hua
   Bose, Shambhunath
   Lim, Soo-Kyoung
   Ansari, AbuZar
   Chin, Young-Won
   Choi, Han Seok
   Kim, Hojun
TI Houttuynia cordata Facilitates Metformin on Ameliorating Insulin
   Resistance Associated with Gut Microbiota Alteration in OLETF Rats
SO GENES
LA English
DT Article
DE Houttuynia cordata; insulin sensitivity; OLETF rat; gut microbiota;
   endotoxin
ID CHAIN FATTY-ACIDS; AKKERMANSIA-MUCINIPHILA; CHOLESTEROL RATIO; WATER
   EXTRACT; LIVER-INJURY; INFLAMMATION; OBESITY; DIET; THUNB.; TALK
AB Metformin and Houttuynia cordata are representative anti-diabetic therapeutics in western and oriental medicine, respectively. The current study examined the synergistic anti-diabetic effect of Houttuynia cordata extraction (HCE) and metformin combination in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Fecal microbiota were analyzed by denaturing gradient gel electrophoresis (DGGE) and real-time PCR. Combining HCE + metformin resulted in significantly ameliorated glucose tolerance (oral glucose tolerance test (OGTT))-the same as metformin alone. Particularly, results of the insulin tolerance test (ITT) showed that combining HCE + metformin dramatically improved insulin sensitivity as compared to metformin treatment alone. Both fecal and serum endotoxin, as well as cytokines (tumor necrosis factor (TNF-) and interleukin 6 (IL-6)) were significantly ameliorated by HCE + metformin compared to metformin alone. Meanwhile, the activation of AMPK (adenosine monophosphate-activated protein kinase) by metformin was distinctly enhanced by HCE. Both of HCE and metformin evidently changed the gut microbiota composition, causing the alteration of bacterial metabolite, like short-chain fatty acids. H. cordata, together with metformin, exerts intensive sensibilization to insulin; the corresponding mechanisms are associated with alleviation of endotoxemia via regulation of gut microbiota, particularly Roseburia, Akkermansia, and Gram-negative bacterium.
C1 [Wang, Jing-Hua; Lim, Soo-Kyoung; Ansari, AbuZar; Kim, Hojun] Dongguk Univ, Dept Rehabil Med Korean Med, 814 Siksa, Goyang 10326, Gyeonggi Do, South Korea.
   [Bose, Shambhunath] NosQuest, USPACE 1A 1103, Daewang Pangyoro 660, Seongnam Si 13494, Gyeonggi Do, South Korea.
   [Chin, Young-Won] Dongguk Univ Seoul, Coll Pharm, Dongguk Io 32, Goyang 10326, Gyeonggi Do, South Korea.
   [Choi, Han Seok] Dongguk Univ, Dept Endocrinol, Dongguk Io 32, Goyang 10326, Gyeonggi Do, South Korea.
C3 Dongguk University; Dongguk University; Dongguk University
RP Kim, H (通讯作者)，Dongguk Univ, Dept Rehabil Med Korean Med, 814 Siksa, Goyang 10326, Gyeonggi Do, South Korea.
EM ewccwang@gmail.com; shambose@yahoo.com; sklim1972@naver.com;
   abu.zar.0313@outlook.com; f2744@dongguk.edu; hschoi402@dumc.or.kr;
   kimklar@gmail.com
RI Choi, Han Seok/AAG-1493-2019; ANSARI, ABUZAR/AAZ-2578-2020; Wang,
   Jing-hua/AAO-2350-2020; Kim, Hojun/AAB-8405-2020; Bose,
   Shambhunath/HKW-2568-2023
OI Wang, Jing-hua/0000-0002-2034-7429; Bose,
   Shambunath/0000-0003-0737-5713; Chin, Young-Won/0000-0001-6964-1779;
   Kim, Hojun/0000-0003-1038-0142
FU Convergence of Conventional Medicine and Traditional Korean Medicine R&D
   program - Ministry of Health and Welfare through the Korea Health
   Industry Development Institute [HI14C0558]
FX This work was supported by the grant of Convergence of Conventional
   Medicine and Traditional Korean Medicine R&D program funded by the
   Ministry of Health and Welfare through the Korea Health Industry
   Development Institute (HI14C0558).
CR Bergheim I, 2006, J PHARMACOL EXP THER, V316, P1053, DOI 10.1124/jpet.105.092122
   Cabreiro F, 2016, CELL HOST MICROBE, V19, P1, DOI 10.1016/j.chom.2015.12.012
   Canfora EE, 2015, NAT REV ENDOCRINOL, V11, P577, DOI 10.1038/nrendo.2015.128
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   Cani PD, 2016, MOL METAB, V5, P743, DOI 10.1016/j.molmet.2016.05.011
   Chen WT, 2014, BIOMEDICINE-TAIWAN, V4, P24, DOI 10.7603/s40681-014-0005-2
   Chen YF, 2013, J BIOMED SCI, V20, DOI 10.1186/1423-0127-20-18
   Chun JM, 2014, BMC COMPLEM ALTERN M, V14, DOI 10.1186/1472-6882-14-234
   Dao MC, 2016, GUT, V65, P426, DOI 10.1136/gutjnl-2014-308778
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   DECKER K, 1990, EUR J BIOCHEM, V192, P245, DOI 10.1111/j.1432-1033.1990.tb19222.x
   den Besten G, 2013, J LIPID RES, V54, P2325, DOI 10.1194/jlr.R036012
   Donath MY, 2014, NAT REV DRUG DISCOV, V13, P465, DOI 10.1038/nrd4275
   Esser N, 2014, DIABETES RES CLIN PR, V105, P141, DOI 10.1016/j.diabres.2014.04.006
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Gao ZG, 2009, DIABETES, V58, P1509, DOI 10.2337/db08-1637
   Gonzalez-Chavez Antonio, 2011, Cir Cir, V79, P126
   Haffner Steven M, 2004, Diabetes Care, V27 Suppl 1, pS68
   Hawley SA, 2002, DIABETES, V51, P2420, DOI 10.2337/diabetes.51.8.2420
   Holman R, 2007, Journ Annu Diabetol Hotel Dieu, P13
   Hossain MK, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17040569
   Hussain A, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0165483
   Hussain A, 2016, FOOD RES INT, V81, P1, DOI 10.1016/j.foodres.2015.12.026
   Jaeschke H, 1996, TOXICOL APPL PHARM, V139, P213, DOI 10.1006/taap.1996.0160
   Kalariya NM, 2012, INVEST OPHTH VIS SCI, V53, P3431, DOI 10.1167/iovs.12-9432
   Kang H, 2014, AM J CHINESE MED, V42, P651, DOI 10.1142/S0192415X14500426
   KAWANO K, 1992, DIABETES, V41, P1422, DOI 10.2337/diabetes.41.11.1422
   Kim GS, 2008, BIOL PHARM BULL, V31, P2012, DOI 10.1248/bpb.31.2012
   Koh SJ, 2014, J GASTROEN HEPATOL, V29, P502, DOI 10.1111/jgh.12435
   Kumar M, 2014, ADV PHARMACOL SCI, V2014, DOI 10.1155/2014/809438
   Kumar Manish, 2014, Pharmacogn Rev, V8, P22, DOI 10.4103/0973-7847.125525
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Lau KM, 2008, J ETHNOPHARMACOL, V118, P79, DOI 10.1016/j.jep.2008.03.018
   Lee JH, 2015, ARCH PHARM RES, V38, P1304, DOI 10.1007/s12272-015-0585-8
   Ley RE, 2016, NAT REV GASTRO HEPAT, V13, P69, DOI 10.1038/nrgastro.2016.4
   Li J, 2015, EXP THER MED, V10, P3, DOI 10.3892/etm.2015.2467
   Lian FM, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0130550
   Lin HV, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0035240
   Long YC, 2006, J CLIN INVEST, V116, P1776, DOI 10.1172/JCI29044
   Mata N, 2011, LIPIDS HEALTH DIS, V10, DOI 10.1186/1476-511X-10-94
   Miyata M, 2010, J NUTR SCI VITAMINOL, V56, P150, DOI 10.3177/jnsv.56.150
   Mooradian AD, 2009, NAT CLIN PRACT ENDOC, V5, P150, DOI 10.1038/ncpendmet1066
   Moran TH, 2006, PHILOS T R SOC B, V361, P1211, DOI 10.1098/rstb.2006.1857
   Murguia-Romero M, 2013, J LIPID RES, V54, P2795, DOI 10.1194/jlr.M040584
   Murri M, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-46
   Noriega BS, 2016, CASE REP MED, V2016, DOI 10.1155/2016/3089303
   Pedersen HK, 2016, NATURE, V535, P376, DOI 10.1038/nature18646
   Poolsil P., 2017, Pharmacognosy Journal, V9, P382, DOI 10.5530/pj.2017.3.65
   Robinson AC, 1998, DIABETES CARE, V21, P701, DOI 10.2337/diacare.21.5.701
   Ryan KK, 2014, NATURE, V509, P183, DOI 10.1038/nature13135
   Sanz Y, 2010, P NUTR SOC, V69, P434, DOI 10.1017/S0029665110001813
   Sartor RB, 2008, P NATL ACAD SCI USA, V105, P16413, DOI 10.1073/pnas.0809363105
   Schneeberger M, 2015, SCI REP-UK, V5, DOI 10.1038/srep16643
   Shaw RJ, 2013, NAT MED, V19, P1570, DOI 10.1038/nm.3414
   Shin NR, 2016, LETT APPL MICROBIOL, V62, P68, DOI 10.1111/lam.12512
   Shin N. R., 2013, GUT
   Singleton VL, 1999, METHOD ENZYMOL, V299, P152
   Suri RS, 2009, KIDNEY INT, V75, pS44, DOI 10.1038/ki.2008.619
   Tremaroli V, 2012, NATURE, V489, P242, DOI 10.1038/nature11552
   Tsutsui H, 2003, CURR MOL MED, V3, P545, DOI 10.2174/1566524033479618
   Vega GL, 2014, J INVEST MED, V62, P345, DOI 10.2310/JIM.0000000000000044
   Waisundara VY, 2008, AM J CHINESE MED, V36, P517, DOI 10.1142/S0192415X08005953
   [王海颖 WANG Hai-ying], 2009, [中国新药杂志, Chinese Journal New Drugs], V18, P1540
   Wang JH, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0086117
   Wang JH, 2015, SCI REP-UK, V5, DOI 10.1038/srep08391
   World Health Organization, 2014, GLOB HLTH EST DEATHS
   World Health Organization, 2012, GLOBAL STATUS REPORT
   Zhang X, 2015, SCI REP-UK, V5, DOI 10.1038/srep14405
   Zhang Y, 2016, EVID-BASED COMPL ALT, V2016, DOI 10.1155/2016/1592731
NR 71
TC 23
Z9 24
U1 3
U2 18
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2073-4425
J9 GENES-BASEL
JI Genes
PD OCT
PY 2017
VL 8
IS 10
AR 239
DI 10.3390/genes8100239
PG 19
WC Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity
GA FM2WI
UT WOS:000414862300004
PM 28937612
OA Green Submitted, Green Published, gold
DA 2023-06-08
ER

PT J
AU Cao, TTB
   Wu, KC
   Hsu, JL
   Chang, CS
   Chou, CH
   Lin, CY
   Liao, YM
   Lin, PC
   Yang, LY
   Lin, HW
AF Cao, Thao T. B.
   Wu, Kun-Chang
   Hsu, Jye-Lin
   Chang, Chih-Shiang
   Chou, Chiahung
   Lin, Chen-Yuan
   Liao, Yu-Min
   Lin, Pei-Chun
   Yang, Liang-Yo
   Lin, Hsiang-Wen
TI Effects of Non-insulin Anti-hyperglycemic Agents on Gut Microbiota: A
   Systematic Review on Human and Animal Studies
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE anti-hyperglycemic drugs; microbiome; microbiota; association;
   systematic review
ID METFORMIN ALTERS; INTESTINAL MICROBIOTA; BILE-ACIDS; IMPROVEMENT; MICE;
   MODULATION; METAGENOME; ACARBOSE; OBESITY; WEIGHT
AB Background:As growing evidence links gut microbiota with the therapeutic efficacy and side effects of anti-hyperglycemic drugs, this article aims to provide a systematic review of the reciprocal interactions between anti-hyperglycemic drugs and gut microbiota taxa, which underlie the effect of the gut microbiome on diabetic control via bug-host interactions. Method:We followed the PRISMA requirements to perform a systematic review on human vs. animal gut microbiota data in PubMed, SCOPUS, and EMBASE databases, and used Cochrane, ROBIN-I, and SYRCLE tools to assess potential bias risks. The outcomes of assessment were trends on gut microbiota taxa, diversity, and associations with metabolic control (e.g., glucose, lipid) following anti-hyperglycemic treatment. Results:Of 2,804 citations, 64 studies (17/humans; 47/mice) were included. In human studies, seven were randomized trials using metformin or acarbose in obese, pre-diabetes, and type 2 diabetes (T2D) patients. Treatment of pre-diabetes and newly diagnosed T2D patients with metformin or acarbose was associated with decreases in genus ofBacteroides, accompanied by increases in bothBifidobacteriumandLactobacillus. Additionally, T2D patients receiving metformin showed increases in various taxa of the orderEnterobacterialesand the speciesAkkermansia muciniphila. Of seven studies with significant differences in beta-diversity, the incremental specific taxa were associated with the improvement of glucose and lipid profiles. In mice, the effects of metformin onA. muciniphilawere similar, but an inverse association withBacteroideswas reported. Animal studies on other anti-hyperglycemic drugs, however, showed substantial variations in results. Conclusions:The changes in specific taxa and beta-diversity of gut microbiota were associated with metformin and acarbose in humans while pertinent information for other anti-hyperglycemic drugs could only be obtained in rodent studies. Further human studies on anti-hyperglycemic drugs other than metformin and acarbose are needed to explore gut microbiota's role in their therapeutic efficacies and side effects.
C1 [Cao, Thao T. B.; Wu, Kun-Chang; Chang, Chih-Shiang; Lin, Chen-Yuan; Lin, Pei-Chun; Lin, Hsiang-Wen] China Med Univ, Sch Pharm & Grad Inst, Taichung, Taiwan.
   [Cao, Thao T. B.] Hanoi Univ Pharm, Dept Clin Pharm, Hanoi, Vietnam.
   [Hsu, Jye-Lin] China Med Univ, Grad Inst Biomed Sci, Taichung, Taiwan.
   [Chou, Chiahung] Auburn Univ, Harrison Sch Pharm, Dept Hlth Outcomes Res & Policy, Auburn, AL 36849 USA.
   [Chou, Chiahung] China Med Univ Hosp, Dept Med Res, Taichung, Taiwan.
   [Lin, Chen-Yuan; Liao, Yu-Min] China Med Univ Hosp, Div Hematol & Oncol, Taichung, Taiwan.
   [Yang, Liang-Yo] China Med Univ, Sch Med, Dept Physiol, Coll Med, Taichung, Taiwan.
   [Yang, Liang-Yo] China Med Univ Hosp, Lab Neural Repair, Taichung, Taiwan.
   [Yang, Liang-Yo] China Med Univ Hosp, Biomed Technol Res & Dev Ctr, Taichung, Taiwan.
   [Lin, Hsiang-Wen] China Med Univ Hosp, Dept Pharm, Taichung, Taiwan.
   [Lin, Hsiang-Wen] Univ Illinois, Coll Pharm, Dept Pharm Syst Outcomes & Policy, Chicago, IL 60607 USA.
C3 China Medical University Taiwan; Hanoi University of Pharmacy; China
   Medical University Taiwan; Auburn University System; Auburn University;
   China Medical University Taiwan; China Medical University Hospital -
   Taiwan; China Medical University Taiwan; China Medical University
   Hospital - Taiwan; China Medical University Taiwan; China Medical
   University Taiwan; China Medical University Hospital - Taiwan; China
   Medical University Taiwan; China Medical University Hospital - Taiwan;
   China Medical University Taiwan; China Medical University Hospital -
   Taiwan; University of Illinois System; University of Illinois Chicago;
   University of Illinois Chicago Hospital
RP Lin, HW (通讯作者)，China Med Univ, Sch Pharm & Grad Inst, Taichung, Taiwan.; Lin, HW (通讯作者)，China Med Univ Hosp, Dept Pharm, Taichung, Taiwan.; Lin, HW (通讯作者)，Univ Illinois, Coll Pharm, Dept Pharm Syst Outcomes & Policy, Chicago, IL 60607 USA.
EM hsiangwl@gmail.com
RI Lin, Chen/GRR-2799-2022
FU China Medical University [CMU107-Z-03, CMU108-N-03, CMU-108-Z-07,
   1075955A]; Ministry of Science and Technology [MOST 109-2320-B-039-023,
   109-2622-8-039-002-TB1, 108-2911-I-039-301]; Ministry of Education
   Center-of-Excellence under Grant for Drug Development Center, China
   Medical University, Taichung, Taiwan
FX This research was partially supported by China Medical University under
   Grant CMU107-Z-03, CMU108-N-03, CMU107-Z-03, CMU-108-Z-07, and 1075955A;
   Ministry of Science and Technology under Grant MOST 109-2320-B-039-023,
   109-2622-8-039-002-TB1, and 108-2911-I-039-301; Ministry of Education
   Center-of-Excellence under Grant for Drug Development Center, China
   Medical University, Taichung, Taiwan. The funding agencies played no
   role in the study implementation, analysis or interpretation of data, or
   preparation and review or approval of the manuscript.
CR Adeshirlarijaney A, 2020, GUT MICROBES, V11, P253, DOI 10.1080/19490976.2020.1717719
   Adeshirlarijaney A, 2019, AM J PHYSIOL-ENDOC M, V317, pE1121, DOI 10.1152/ajpendo.00245.2019
   [Anonymous], 2011, WORLD CHIN J DIG, DOI DOI 10.11569/WCJD.V19.I19.2058
   Barengolts E, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0194171
   Bauer PV, 2018, CELL METAB, V27, P101, DOI 10.1016/j.cmet.2017.09.019
   Baxter NT, 2019, MSPHERE, V4, DOI [10.1128/mSphere.00528-18, 10.1128/msphere.00528-18]
   Bryrup T, 2019, DIABETOLOGIA, V62, P1024, DOI 10.1007/s00125-019-4848-7
   Bytzer P, 2001, ALIMENT PHARM THER, V15, P137, DOI 10.1046/j.1365-2036.2001.00896.x
   Candela M, 2016, BRIT J NUTR, V116, P80, DOI 10.1017/S0007114516001045
   Cani PD, 2009, GUT, V58, P1091, DOI 10.1136/gut.2008.165886
   Dalile B, 2019, NAT REV GASTRO HEPAT, V16, P461, DOI 10.1038/s41575-019-0157-3
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Dennison CA, 2017, FRONT ENDOCRINOL, V8, DOI 10.3389/fendo.2017.00301
   Derrien M, 2017, MICROB PATHOGENESIS, V106, P171, DOI 10.1016/j.micpath.2016.02.005
   Do HJ, 2016, ENDOCR J, V63, P691, DOI 10.1507/endocrj.EJ15-0747
   Dong TS, 2019, AM J PHYSIOL-GASTR L, V317, pG763, DOI 10.1152/ajpgi.00170.2019
   Ejtahed HS, 2019, EUR J ENDOCRINOL, V180, P165, DOI [10.1530/EJE-18-0826, 10.1530/eje-18-0826]
   Elbere I, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0204317
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Gu YY, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-01682-2
   Gurung M, 2020, EBIOMEDICINE, V51, DOI 10.1016/j.ebiom.2019.11.051
   Han K, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0182467
   Higgins JPT, 2011, BMJ-BRIT MED J, V343, DOI 10.1136/bmj.d5928
   Hooijmans CR, 2014, BMC MED RES METHODOL, V14, DOI 10.1186/1471-2288-14-43
   Huang F, 2018, INT J FOOD SCI NUTR, V69, P729, DOI 10.1080/09637486.2017.1408059
   Ji SQ, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00704
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kaya D, 2019, CELLS-BASEL, V8, DOI 10.3390/cells8101153
   King CH, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0206484
   Kishida Y, 2017, J GASTROENTEROL, V52, P1180, DOI 10.1007/s00535-017-1331-4
   Kyriachenko Y, 2019, WORLD J DIABETES, V10, P154, DOI 10.4239/wjd.v10.i3.154
   Lee DM, 2018, CARDIOVASC DIABETOL, V17, DOI 10.1186/s12933-018-0708-x
   Lee H, 2018, GUT MICROBES, V9, P155, DOI 10.1080/19490976.2017.1405209
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Ley RE, 2005, P NATL ACAD SCI USA, V102, P11070, DOI 10.1073/pnas.0504978102
   Li LY, 2018, CURR PHARM DESIGN, V24, P3223, DOI 10.2174/1381612824666180912143434
   Li YQ, 2014, INDIAN J MICROBIOL, V54, P12, DOI 10.1007/s12088-013-0410-3
   Liao XY, 2019, EBIOMEDICINE, V44, P665, DOI 10.1016/j.ebiom.2019.03.057
   Liberati A, 2009, BMJ-BRIT MED J, V339, DOI [10.1371/journal.pmed.1000097, 10.1136/bmj.b2700, 10.1136/bmj.b4037, 10.7326/0003-4819-151-4-200908180-00136]
   Liu GM, 2018, MOL NUTR FOOD RES, V62, DOI 10.1002/mnfr.201700954
   Ma W, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.01336
   Madsen MSA, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-52103-x
   Mishima E, 2018, AM J PHYSIOL-RENAL, V315, pF824, DOI 10.1152/ajprenal.00314.2017
   Montandon SA, 2017, GENES-BASEL, V8, DOI 10.3390/genes8100250
   Moreira GV, 2018, J NUTR BIOCHEM, V62, P143, DOI 10.1016/j.jnutbio.2018.07.009
   Napolitano A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100778
   Olivares M, 2018, DIABETOLOGIA, V61, P1838, DOI 10.1007/s00125-018-4647-6
   Pascale A, 2019, CURR OPIN PHARMACOL, V49, P1, DOI 10.1016/j.coph.2019.03.011
   Pedersen C, 2018, PHYSIOL REP, V6, DOI 10.14814/phy2.13649
   Pyra KA, 2012, J NUTR, V142, P213, DOI 10.3945/jn.111.147132
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Ridlon JM, 2014, CURR OPIN GASTROEN, V30, P332, DOI 10.1097/MOG.0000000000000057
   Rizzatti G, 2017, BIOMED RES INT, V2017, DOI 10.1155/2017/9351507
   Ryan PM, 2020, CAN J DIABETES, V44, P146, DOI 10.1016/j.jcjd.2019.05.008
   Salomaki-Myftari H, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0163805
   Scells H, 2017, CIKM'17: PROCEEDINGS OF THE 2017 ACM CONFERENCE ON INFORMATION AND KNOWLEDGE MANAGEMENT, P2291, DOI 10.1145/3132847.3133080
   Sedighi M, 2017, MICROB PATHOGENESIS, V111, P362, DOI 10.1016/j.micpath.2017.08.038
   Shin NR, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.02271
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Smith BJ, 2019, BMC MICROBIOL, V19, DOI 10.1186/s12866-019-1494-7
   Stein SA, 2013, EXPERT OPIN DRUG SAF, V12, P153, DOI 10.1517/14740338.2013.752813
   Sterne JAC, 2016, BMJ-BRIT MED J, V355, DOI 10.1136/bmj.i4919
   Su BL, 2015, J DIABETES, V7, P729, DOI 10.1111/1753-0407.12232
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Nguyen TLA, 2015, DIS MODEL MECH, V8, P1, DOI 10.1242/dmm.017400
   Tiderencel KA, 2020, DIABETES-METAB RES, V36, DOI 10.1002/dmrr.3213
   Tong XL, 2018, MBIO, V9, DOI 10.1128/mBio.02392-17
   Wang JJ, 2020, J DIABETES RES, V2020, DOI 10.1155/2020/6047145
   Wang JH, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00620
   Wang JH, 2017, GENES-BASEL, V8, DOI 10.3390/genes8100239
   Wang L, 2016, SCI REP-UK, V6, DOI [10.1038/srep38380, 10.1038/srep33251, 10.1038/srep20004]
   Wang Zhang, 2018, Endocrinol Diabetes Metab, V1, pe00009, DOI 10.1002/edm2.9
   Whang A, 2019, EBIOMEDICINE, V39, P591, DOI 10.1016/j.ebiom.2018.11.046
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Xu GD, 2018, BIOL PHARM BULL, V41, P1024, DOI 10.1248/bpb.b17-00978
   [徐萌 Xu Meng], 2018, [中草药, Chinese Traditional and Herbal Drugs], V49, P3056
   Xue J, 2019, ENDOCR J, V66, P859, DOI 10.1507/endocrj.EJ18-0567
   Yan XF, 2016, J DIABETES RES, V2016, DOI 10.1155/2016/2093171
   Yuan X, 2018, J CELL BIOCHEM, V119, P10067, DOI 10.1002/jcb.27343
   Zhang FH, 2019, ENDOCRINE, V66, P485, DOI 10.1007/s12020-019-02041-5
   Zhang MC, 2019, BMJ OPEN DIAB RES CA, V7, DOI 10.1136/bmjdrc-2019-000717
   Zhang Q, 2018, EXP BIOL MED, V243, P34, DOI 10.1177/1535370217743765
   Zhang Q, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0184735
   Zhang W, 2019, BIOMED PHARMACOTHER, V118, DOI 10.1016/j.biopha.2019.109131
   Zhang XY, 2017, DIABETES THER, V8, P293, DOI 10.1007/s13300-017-0226-y
   Zhang X, 2015, SCI REP-UK, V5, DOI 10.1038/srep14405
   Zhao JD, 2019, EVID-BASED COMPL ALT, V2019, DOI 10.1155/2019/6976394
   Zhao L, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00233
   Zheng JL, 2018, J AGR FOOD CHEM, V66, P5821, DOI [10.1021/acsjafc.8b00829, 10.1021/acs.jafc.8b00829]
   Zhou ZY, 2016, ACTA PHARMACOL SIN, V37, P1063, DOI 10.1038/aps.2016.21
NR 90
TC 16
Z9 17
U1 1
U2 10
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD SEP 23
PY 2020
VL 11
AR 573891
DI 10.3389/fendo.2020.573891
PG 25
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA NX1OS
UT WOS:000575487000001
PM 33071980
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Li, F
   Ke, HR
   Wang, SQ
   Mao, W
   Fu, CX
   Chen, X
   Fu, QQ
   Qin, XR
   Huang, YH
   Li, BD
   Li, SB
   Xing, JY
   Wang, MH
   Deng, WL
AF Li, Fang
   Ke, Haoran
   Wang, Siqi
   Mao, Wei
   Fu, Cexiong
   Chen, Xi
   Fu, Qingqing
   Qin, Xiaori
   Huang, Yonghua
   Li, Bidan
   Li, Shibing
   Xing, Jingying
   Wang, Minhui
   Deng, Wenlin
TI Leaky Gut Plays a Critical Role in the Pathophysiology of Autism in Mice
   by Activating the Lipopolysaccharide-Mediated Toll-Like Receptor
   4-Myeloid Differentiation Factor 88-Nuclear Factor Kappa B Signaling
   Pathway
SO NEUROSCIENCE BULLETIN
LA English
DT Article; Early Access
DE Autism; Gut; Lipopolysaccharide; Toll-like receptor 4; Metformin
ID ELEVATED PLUS-MAZE; MOUSE MODEL; GASTROINTESTINAL DYSFUNCTION;
   INTESTINAL PERMEABILITY; INFLAMMATORY RESPONSES; SPECTRUM DISORDERS;
   BRAIN AXIS; METFORMIN; CHILDREN; MICROBIOTA
AB Increased intestinal barrier permeability, leaky gut, has been reported in patients with autism. However, its contribution to the development of autism has not been determined. We selected dextran sulfate sodium (DSS) to disrupt and metformin to repair the intestinal barrier in BTBR T(+)tf/J autistic mice to test this hypothesis. DSS treatment resulted in a decreased affinity for social proximity; however, autistic behaviors in mice were improved after the administration of metformin. We found an increased affinity for social proximity/social memory and decreased repetitive and anxiety-related behaviors. The concentration of lipopolysaccharides in blood decreased after the administration of metformin. The expression levels of the key molecules in the toll-like receptor 4 (TLR4)-myeloid differentiation factor 88 (MyD88)-nuclear factor kappa B (NF-kappa B) pathway and their downstream inflammatory cytokines in the cerebral cortex were both repressed. Thus, "leaky gut " could be a trigger for the development of autism via activation of the lipopolysaccharide-mediated TLR4-MyD88-NF-kappa B pathway.
C1 [Li, Fang; Mao, Wei; Qin, Xiaori; Huang, Yonghua] Hainan Med Univ, Hainan Gen Hosp, Gastroenterol Endoscopy Ctr, Dept Gastroenterol,Hainan Affiliated Hosp, Haikou 570311, Peoples R China.
   [Ke, Haoran] Southern Med Univ, Nanfang Hosp, Dept Infect Dis, Hepatol Unit, Guangzhou 510515, Peoples R China.
   [Wang, Siqi] Guangzhou Med Univ, Dept Gastroenterol, Affiliated Hosp 1, Guangzhou 510120, Peoples R China.
   [Fu, Cexiong; Li, Bidan] Hainan Med Univ, Hainan Gen Hosp, Dept Hepatopancreatobiliary Surg, Hainan Affiliated Hosp, Haikou 570311, Peoples R China.
   [Chen, Xi] Hainan Med Univ, Hosp Hainan Prov, Hainan Gen Hosp, Dept Otorhinolaryngol,Hainan Affiliated Hosp,Otola, Haikou 570311, Peoples R China.
   [Fu, Qingqing] Hainan Med Univ, Hainan Gen Hosp, Dept Radiol, Hainan Affiliated Hosp, Haikou 570311, Peoples R China.
   [Li, Shibing] Hainan Med Univ, Hainan Gen Hosp, Dept Pediat Surg, Hainan Affiliated Hosp, Haikou 570311, Peoples R China.
   [Xing, Jingying] Hainan Med Univ, Hainan Gen Hosp, Dept Gastroenterol, Hainan Affiliated Hosp, Haikou 570311, Peoples R China.
   [Wang, Minhui] Hainan Med Coll, Hainan Gen Hosp, Dept Nephrol, Hainan Affiliated Hosp, Haikou 570311, Peoples R China.
   [Deng, Wenlin] Sun Yat sen Univ, Affiliated Hosp 6, Dept Pediat, Guangzhou 510655, Peoples R China.
C3 Hainan Medical University; Southern Medical University - China;
   Guangzhou Medical University; Hainan Medical University; Hainan Medical
   University; Hainan Medical University; Hainan Medical University; Hainan
   Medical University; Hainan Medical University; Sun Yat Sen University
RP Deng, WL (通讯作者)，Sun Yat sen Univ, Affiliated Hosp 6, Dept Pediat, Guangzhou 510655, Peoples R China.
EM dengwl3@mail.sysu.edu.cn
RI fu, cexiong/A-4197-2011
FU National Natural Science Foundation of China; Hainan Provincial Natural
   Science Foundation of China;  [82100609];  [821QN0982]
FX AcknowledgementsThis work was supported by the National Natural Science
   Foundation of China (82100609) and the Hainan Provincial Natural Science
   Foundation of China (821QN0982).
CR Al-Ayadhi L, 2021, GUT PATHOG, V13, DOI 10.1186/s13099-021-00448-y
   Amodeo DA, 2012, BEHAV BRAIN RES, V227, P64, DOI 10.1016/j.bbr.2011.10.032
   Angoa-Perez M, 2013, JOVE-J VIS EXP, DOI 10.3791/50978
   Belovicova Kristina, 2017, Interdiscip Toxicol, V10, P40, DOI 10.1515/intox-2017-0006
   Brown GC, 2019, J NEUROINFLAMM, V16, DOI 10.1186/s12974-019-1564-7
   Chaidez V, 2014, J AUTISM DEV DISORD, V44, P1117, DOI 10.1007/s10803-013-1973-x
   Chang Yu-Chi, 2017, Curr Protoc Toxicol, V72, DOI 10.1002/cptx.19
   Chelakkot Chaithanya, 2018, Exp Mol Med, V50, P1, DOI 10.1038/s12276-018-0126-x
   Chidambaram SB, 2020, ADV NEUROBIOL, V24, P587, DOI 10.1007/978-3-030-30402-7_21
   Clapp M, 2017, CLINICS PRACT, V7, P131, DOI 10.4081/cp.2017.987
   de Magistris L., 2014, COMPREHENSIVE GUIDE, P2047, DOI 10.1007/978-1-4614-4788-7_123
   de Magistris L, 2010, J PEDIATR GASTR NUTR, V51, P418, DOI 10.1097/MPG.0b013e3181dcc4a5
   Deng J, 2018, J CELL MOL MED, V22, P546, DOI 10.1111/jcmm.13342
   Deng WL, 2022, BRAIN RES BULL, V183, P172, DOI 10.1016/j.brainresbull.2022.02.021
   DEufemia P, 1996, ACTA PAEDIATR, V85, P1076, DOI 10.1111/j.1651-2227.1996.tb14220.x
   DiBona VL, 2021, NEUROSCI RES, V172, P99, DOI 10.1016/j.neures.2021.05.007
   Du MR, 2022, FRONT AGING NEUROSCI, V14, DOI 10.3389/fnagi.2022.838173
   Dziedzic A, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21175957
   El-Ansary A, 2014, LIPIDS HEALTH DIS, V13, DOI 10.1186/1476-511X-13-140
   El-Ansary A, 2012, J NEUROINFLAMM, V9, DOI 10.1186/1742-2094-9-265
   Emanuele E, 2010, NEUROSCI LETT, V471, P162, DOI 10.1016/j.neulet.2010.01.033
   Esnafoglu E, 2017, J PEDIATR-US, V188, P240, DOI 10.1016/j.jpeds.2017.04.004
   Faraji J, 2018, TRANSL PSYCHIAT, V8, DOI 10.1038/s41398-018-0280-x
   Fiorentino M, 2016, MOL AUTISM, V7, DOI 10.1186/s13229-016-0110-z
   Fond G, 2015, PATHOL BIOL, V63, P35, DOI 10.1016/j.patbio.2014.10.003
   Fowlie G, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19082251
   GIN H, 1985, METABOLISM, V34, P923, DOI 10.1016/0026-0495(85)90139-8
   Golubeva AV, 2017, EBIOMEDICINE, V24, P166, DOI 10.1016/j.ebiom.2017.09.020
   Gorrindo P, 2012, AUTISM RES, V5, P101, DOI 10.1002/aur.237
   Greene RK, 2019, BIOL PSYCHOL, V142, P1, DOI 10.1016/j.biopsycho.2018.12.008
   Guo M, 2014, CLIN EXP PHARMACOL P, V41, P650, DOI 10.1111/1440-1681.12265
   Harrop C, 2014, J AUTISM DEV DISORD, V44, P1207, DOI 10.1007/s10803-013-1986-5
   Horvath K, 1999, J PEDIATR-US, V135, P559, DOI 10.1016/S0022-3476(99)70052-1
   Israelyan N, 2018, PHARMACOL RES, V132, P1, DOI 10.1016/j.phrs.2018.03.020
   Jyonouchi H, 2002, NEUROPSYCHOBIOLOGY, V46, P76, DOI 10.1159/000065416
   Ke HR, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.726707
   Kelly JR, 2015, FRONT CELL NEUROSCI, V9, DOI 10.3389/fncel.2015.00392
   Kim HS, 2021, TRANSL NEURODEGENER, V10, DOI 10.1186/s40035-021-00273-y
   Kohane IS, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0033224
   Komada Munekazu, 2008, J Vis Exp, DOI 10.3791/1088
   Kraeuter AK, 2019, METHODS MOL BIOL, V1916, P69, DOI 10.1007/978-1-4939-8994-2_4
   Lasheras I, 2020, ASIAN J PSYCHIATR, V47, DOI 10.1016/j.ajp.2019.101874
   Li F, 2020, FASEB J, V34, P15252, DOI 10.1096/fj.202001104R
   Lucchina L, 2014, AUTISM RES, V7, P273, DOI 10.1002/aur.1338
   Madra M, 2020, CHILD ADOL PSYCH CL, V29, P501, DOI 10.1016/j.chc.2020.02.005
   Masi A, 2017, NEUROSCI BULL, V33, P183, DOI 10.1007/s12264-017-0100-y
   Matson JL, 2006, ASSESS TREAT CHILD P, V1, P1
   Matson JL, 2011, RES AUTISM SPECT DIS, V5, P418, DOI 10.1016/j.rasd.2010.06.004
   Matta SM, 2019, BRAIN BEHAV IMMUN, V79, P75, DOI 10.1016/j.bbi.2019.04.037
   McElhanon BO, 2014, PEDIATRICS, V133, P872, DOI 10.1542/peds.2013-3995
   Montvida O, 2018, DIABETES CARE, V41, P69, DOI 10.2337/dc17-1414
   Morais LH, 2021, NAT REV MICROBIOL, V19, P241, DOI 10.1038/s41579-020-00460-0
   Moy SS, 2007, BEHAV BRAIN RES, V176, P4, DOI 10.1016/j.bbr.2006.07.030
   Nadeem A, 2017, BRAIN BEHAV IMMUN, V61, P146, DOI 10.1016/j.bbi.2016.12.024
   Ou ZR, 2018, BRAIN BEHAV IMMUN, V69, P351, DOI 10.1016/j.bbi.2017.12.009
   Penagarikano O, 2015, SCI TRANSL MED, V7, DOI 10.1126/scitranslmed.3010257
   Pernicova I, 2014, NAT REV ENDOCRINOL, V10, P143, DOI 10.1038/nrendo.2013.256
   Plociennikowska A, 2015, CELL MOL LIFE SCI, V72, P557, DOI 10.1007/s00018-014-1762-5
   Rein B, 2020, NAT PROTOC, V15, P3464, DOI 10.1038/s41596-020-0382-9
   Saewanee N, 2021, NEUROSCI RES, V162, P13, DOI 10.1016/j.neures.2019.12.017
   Santocchi E, 2016, BMC PSYCHIATRY, V16, DOI 10.1186/s12888-016-0887-5
   Silverman JL, 2010, NAT REV NEUROSCI, V11, P490, DOI 10.1038/nrn2851
   Silverman JL, 2010, NEUROPSYCHOPHARMACOL, V35, P976, DOI 10.1038/npp.2009.201
   Sportelli C, 2020, FRONT NEUROL, V11, DOI 10.3389/fneur.2020.00556
   Srikantha P, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20092115
   Theoharides TC, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20153611
   Theoharides TC, 2013, J NEUROINFLAMM, V10, DOI 10.1186/1742-2094-10-46
   Vuong HE, 2017, BIOL PSYCHIAT, V81, P411, DOI 10.1016/j.biopsych.2016.08.024
   Walf AA, 2007, NAT PROTOC, V2, P322, DOI 10.1038/nprot.2007.44
   Waye MMY, 2018, PSYCHIAT CLIN NEUROS, V72, P228, DOI 10.1111/pcn.12606
   Xiao L, 2021, FRONT CELL DEV BIOL, V9, DOI 10.3389/fcell.2021.634837
   Yu Y, 2021, J GENET GENOMICS, V48, P755, DOI 10.1016/j.jgg.2021.07.001
NR 72
TC 1
Z9 1
U1 7
U2 7
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1673-7067
EI 1995-8218
J9 NEUROSCI BULL
JI Neurosci. Bull.
PD 2022 DEC 18
PY 2022
DI 10.1007/s12264-022-00993-9
EA DEC 2022
PG 18
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 7B6FS
UT WOS:000899227300001
PM 36528850
OA hybrid
DA 2023-06-08
ER

PT J
AU Kim, E
   Kim, AH
   Lee, Y
   Ji, SC
   Cho, JY
   Yu, KS
   Chung, JY
AF Kim, Eunwoo
   Kim, Andrew Hyoungjin
   Lee, Yujin
   Ji, Sang Chun
   Cho, Joo-Youn
   Yu, Kyung-Sang
   Chung, Jae-Yong
TI Effects of vancomycin-induced gut microbiome alteration on the
   pharmacodynamics of metformin in healthy male subjects
SO CTS-CLINICAL AND TRANSLATIONAL SCIENCE
LA English
DT Article
ID METABOLISM
AB Metformin is a major treatment for type 2 diabetes. This study was conducted to investigate the impact of gut microbiome dysbiosis on the pharmacokinetics and antihyperglycemic effects of metformin. Healthy adult males aged 19-45 years with no defecation abnormalities were recruited for this 4-period clinical study: baseline; post-metformin (i.e., multiple oral doses of 1000 mg metformin on days 1-4); post-vancomycin (i.e., multiple oral doses of 500 mg vancomycin on days 11-17 inducing gut microbiome changes); and post-metformin + vancomycin (i.e., multiple oral doses of 1000 mg metformin on days 16-19). In each period, serum glucose and insulin concentrations following an oral glucose tolerance test, fecal samples for gut microbiome composition, and safety data were obtained. Following metformin dosing, plasma and urine samples for pharmacokinetics were collected. Nine subjects completed the study. The pharmacokinetics of metformin remained unchanged, and the antihyperglycemic effect was significantly decreased after vancomycin administration (p value = 0.039), demonstrating the weak relationship between the pharmacokinetics and pharmacodynamics of metformin. Relative abundances of some genus were changed after vancomycin administration, and tended to correlate with the antihyperglycemic effects of metformin (p value = 0.062 for Erysipelatoclostridium; p value = 0.039 for Enterobacter; and p value = 0.086 for Faecalibacterium). Adverse events occurred in all subjects and were resolved without sequelae. In conclusion, a decrease in the antihyperglycemic effect of metformin was observed after concomitant administration with vancomycin, without changes in metformin pharmacokinetics. The antihyperglycemic effect was tended to correlate with the relative abundance of several genus, suggesting that the effect of metformin is partly attributable to the gut microbiome (ClinicalTrials.gov, NCT03809260).
C1 [Kim, Eunwoo; Kim, Andrew Hyoungjin; Lee, Yujin; Ji, Sang Chun; Cho, Joo-Youn; Yu, Kyung-Sang] Seoul Natl Univ, Coll Med & Hosp, Dept Clin Pharmacol & Therapeut, Seoul, South Korea.
   [Cho, Joo-Youn; Yu, Kyung-Sang] Seoul Natl Univ, Coll Med & Hosp, Dept Biomed Sci, Seoul, South Korea.
   [Chung, Jae-Yong] Seoul Natl Univ, Coll Med, Dept Clin Pharmacol & Therapeut, Seongnam, South Korea.
   [Chung, Jae-Yong] Bundang Hosp, Seongnam, South Korea.
   [Kim, Andrew Hyoungjin] Washington Univ, Sch Med, Div Infect Dis, Edison Family Ctr Genome Sci & Syst Biol,Dept Med, St Louis, MO 63110 USA.
C3 Seoul National University (SNU); Seoul National University (SNU); Seoul
   National University (SNU); Washington University (WUSTL)
RP Chung, JY (通讯作者)，Seoul Natl Univ, Coll Med, Dept Clin Pharmacol & Therapeut, Seongnam, South Korea.; Chung, JY (通讯作者)，Bundang Hosp, Seongnam, South Korea.
EM jychung@snubh.org
RI Chung, Jae Yong/J-5646-2012; Cho, Joo-Youn/ABC-2044-2021; Cho,
   Joo-Youn/J-5672-2012
OI Cho, Joo-Youn/0000-0001-9270-8273; Cho, Joo-Youn/0000-0001-9270-8273;
   Chung, Jae Yong/0000-0003-4188-2786
FU National Research Foundation of Korea [NRF-2018R1D1A1B07044406]
FX This study was funded by National Research Foundation of Korea (No.
   NRF-2018R1D1A1B07044406), Seoul, Republic of Korea.
CR Ahmad A, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0226372
   [Anonymous], 2020, MICROBIOMEANALYSIS
   Basolo A, 2020, NAT MED, V26, P589, DOI 10.1038/s41591-020-0801-z
   Breton J, 2016, CELL METAB, V23, P324, DOI 10.1016/j.cmet.2015.10.017
   Bryrup T, 2019, DIABETOLOGIA, V62, P1024, DOI 10.1007/s00125-019-4848-7
   Chung H, 2018, PLOS ONE, V13, DOI [10.1371/journal.pone.0191258, 10.1371/Journal.pone.0191258]
   Dhariwal A, 2017, NUCLEIC ACIDS RES, V45, pW180, DOI 10.1093/nar/gkx295
   Dujic T, 2017, CLIN PHARMACOL THER, V101, P763, DOI 10.1002/cpt.567
   Elbere I, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0204317
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Huang M, 2015, CARBOHYD POLYM, V117, P91, DOI 10.1016/j.carbpol.2014.09.008
   Isaac S, 2017, J ANTIMICROB CHEMOTH, V72, P128, DOI 10.1093/jac/dkw383
   Kyriachenko Y, 2019, WORLD J DIABETES, V10, P154, DOI 10.4239/wjd.v10.i3.154
   Lee H, 2018, GUT MICROBES, V9, P155, DOI 10.1080/19490976.2017.1405209
   Li LL, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-58048-w
   Li Q, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-62224-3
   Minamii T, 2018, J DIABETES INVEST, V9, P701, DOI 10.1111/jdi.12864
   Oh J, 2016, DIABETES OBES METAB, V18, P104, DOI 10.1111/dom.12577
   Priyadarsini S, 2020, MICROB PATHOGENESIS, V149, DOI 10.1016/j.micpath.2020.104276
   Rao S, 2011, SCAND J INFECT DIS, V43, P386, DOI 10.3109/00365548.2010.544671
   Rehani PR, 2019, J DIABETES RES, V2019, DOI 10.1155/2019/4267357
   Reijnders D, 2016, CELL METAB, V24, P63, DOI [10.1016/j.cmet.2016.06.016, 10.1016/j.cmet.2016.07.008]
   Rena G, 2017, DIABETOLOGIA, V60, P1577, DOI 10.1007/s00125-017-4342-z
   Ryan PM, 2020, CAN J DIABETES, V44, P146, DOI 10.1016/j.jcjd.2019.05.008
   Shreiner AB, 2015, CURR OPIN GASTROEN, V31, P69, DOI 10.1097/MOG.0000000000000139
   SUM CF, 1992, DIABETIC MED, V9, P61, DOI 10.1111/j.1464-5491.1992.tb01716.x
   Wang K, 2019, CELL REP, V26, P222, DOI 10.1016/j.celrep.2018.12.028
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Zhang CC, 2019, MOL NUTR FOOD RES, V63, DOI 10.1002/mnfr.201900248
   Zhang FH, 2019, ENDOCRINE, V66, P485, DOI 10.1007/s12020-019-02041-5
   Zhang JH, 2018, DRUG METAB REV, V50, P357, DOI 10.1080/03602532.2018.1497647
   Zhang XY, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0071108
NR 32
TC 6
Z9 6
U1 1
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1752-8054
EI 1752-8062
J9 CTS-CLIN TRANSL SCI
JI CTS-Clin. Transl. Sci.
PD SEP
PY 2021
VL 14
IS 5
BP 1955
EP 1966
DI 10.1111/cts.13051
EA MAY 2021
PG 12
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA WQ2LD
UT WOS:000656277800001
PM 33982376
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Kalia, VC
   Gong, CJ
   Shanmugam, R
   Lin, H
   Zhang, LY
   Lee, JK
AF Kalia, Vipin Chandra
   Gong, Chunjie
   Shanmugam, Ramasamy
   Lin, Hui
   Zhang, Liaoyuan
   Lee, Jung-Kul
TI The Emerging Biotherapeutic Agent: Akkermansia
SO INDIAN JOURNAL OF MICROBIOLOGY
LA English
DT Review
DE Akkermansia; Biotherapy; Microbiota; Dysbiosis; Eubiosis; Obesity;
   Diabetes; Cancer; Aging
ID GUT MICROBIOME; INTESTINAL MICROBIOTA; MUCINIPHILA; INFLAMMATION;
   INDIVIDUALS; ASSOCIATION; CONSUMPTION; POPULATION; METFORMIN; IMMUNITY
AB The human gastrointestinal tract (GIT) is a well-recognized hub of microbial activities. The microbiota harboring the mucus layer of the GIT act as a defense against noxious substances, and pathogens including Clostridium difficile, Enterococcus faecium, Escherichia coli, Salmonella Typhimurium. Toxins, pathogens, and antibiotics perturb the commensal floral composition within the GIT. Imbalanced gut microbiota leads to dysbiosis, manifested as diseases ranging from obesity, diabetes, and cancer to reduced lifespan. Among the bacteria present in the gut microbiome, the most beneficial are those representing Firmicutes and Bacteroidetes. Recent studies have revealed the emergence of a novel biotherapeutic agent, Akkermansia, which is instrumental in regaining eubiosis and conferring various health benefits.
C1 [Kalia, Vipin Chandra; Shanmugam, Ramasamy; Lee, Jung-Kul] Konkuk Univ, Dept Chem Engn, 1 Hwayang Dong, Seoul 05029, South Korea.
   [Gong, Chunjie] Hubei Univ Technol, Natl Ctr Cellular Regulat & Mol Pharmaceut 111, Key Lab Fermentat Engn, Minist Educ, Wuhan 430068, Peoples R China.
   [Lin, Hui; Zhang, Liaoyuan] Fujian Agr & Forestry Univ, Coll Life Sci, Gutian Edible Fungi Res Inst, Fuzhou 350002, Peoples R China.
C3 Konkuk University; Hubei University of Technology; Fujian Agriculture &
   Forestry University
RP Kalia, VC; Lee, JK (通讯作者)，Konkuk Univ, Dept Chem Engn, 1 Hwayang Dong, Seoul 05029, South Korea.; Zhang, LY (通讯作者)，Fujian Agr & Forestry Univ, Coll Life Sci, Gutian Edible Fungi Res Inst, Fuzhou 350002, Peoples R China.
EM vckaliaku@gmail.com; zliaoyuan@126.com; jkrhee@konkuk.ac.kr
FU Basic Science Research Program through the National Research Foundation
   of Korea (NRF) - Ministry of Science, ICT & Future Planning
   [NRF-2021R1I1A1A01060963, NRF-2020R1I1A1A01073483]; Konkuk University
   Researcher Fund
FX This research was supported by the Basic Science Research Program
   through the National Research Foundation of Korea (NRF) funded by the
   Ministry of Science, ICT & Future Planning (NRF-2021R1I1A1A01060963,
   NRF-2020R1I1A1A01073483). This paper was supported by Konkuk University
   Researcher Fund in 2020.
CR Anhe FF, 2015, GUT, V64, P872, DOI 10.1136/gutjnl-2014-307142
   Azad MA, 2018, BIOMED RES INT, V2018, DOI 10.1155/2018/8063647
   Bajagai YS, 2020, APPL MICROBIOL BIOT, V104, P10631, DOI 10.1007/s00253-020-10998-x
   Baldwin J, 2016, J NUTR BIOCHEM, V27, P123, DOI 10.1016/j.jnutbio.2015.08.027
   Barcena C, 2019, NAT MED, V25, P1234, DOI 10.1038/s41591-019-0504-5
   Belzer C, 2012, ISME J, V6, P1449, DOI 10.1038/ismej.2012.6
   Blaser MJ, 2014, J CLIN INVEST, V124, P4162, DOI 10.1172/JCI78366
   Bodkhe R, 2019, FRONT MICROBIOL, V10, DOI 10.3389/fmicb.2019.00164
   Bodogai M, 2018, SCI TRANSL MED, V10, DOI 10.1126/scitranslmed.aat4271
   Borda-Molina D, 2018, COMPUT STRUCT BIOTEC, V16, P131, DOI 10.1016/j.csbj.2018.03.002
   Buffie CG, 2015, NATURE, V517, P205, DOI 10.1038/nature13828
   Cani PD, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.01765
   Clavijo V, 2018, POULTRY SCI, V97, P1006, DOI 10.3382/ps/pex359
   Coetzer WG, 2021, INDIAN J MICROBIOL, V61, P81, DOI 10.1007/s12088-020-00900-8
   Cornick S, 2015, TISSUE BARRIERS, V3, DOI 10.4161/21688370.2014.982426
   Coutzac C, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-16079-x
   Cox LM, 2014, CELL, V158, P705, DOI 10.1016/j.cell.2014.05.052
   Das T, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-82538-0
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   De Vadder F, 2014, CELL, V156, P84, DOI 10.1016/j.cell.2013.12.016
   Depommier C, 2019, NAT MED, V25, P1096, DOI 10.1038/s41591-019-0495-2
   Derrien M, 2004, INT J SYST EVOL MICR, V54, P1469, DOI 10.1099/ijs.0.02873-0
   Carrasco JMD, 2019, MICROORGANISMS, V7, DOI 10.3390/microorganisms7100374
   Dinh DM, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0155405
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Fluckiger A, 2020, SCIENCE, V369, P936, DOI 10.1126/science.aax0701
   Gaike AH, 2020, MSYSTEMS, V5, DOI 10.1128/mSystems.00578-19
   Gilbert JA, 2018, NAT MED, V24, P392, DOI 10.1038/nm.4517
   Grajeda-Iglesias C, 2021, AGING-US, V13, P6375, DOI 10.18632/aging.202739
   Gupta V, 2020, INDIAN J MICROBIOL, V60, P1, DOI 10.1007/s12088-019-00852-8
   Han M, 2017, PROTEIN PEPTIDE LETT, V24, P388, DOI 10.2174/0929866524666170220113312
   Iebba V, 2016, NEW MICROBIOL, V39, P1
   Jayachandran M, 2020, CRIT REV FOOD SCI, V60, P2265, DOI 10.1080/10408398.2019.1632789
   Kalia VC., 2019, WASTE MANAGEMENT TRE
   Kalia VC, 2022, SEMIN CANCER BIOL, V86, P1014, DOI 10.1016/j.semcancer.2021.05.012
   Kawabata K, 2019, MOLECULES, V24, DOI 10.3390/molecules24020370
   Kulkarni AS, 2019, INDIAN J MICROBIOL, V59, P90, DOI 10.1007/s12088-018-0742-0
   Kumar R, 2020, INDIAN J MICROBIOL, V60, P12, DOI 10.1007/s12088-019-00808-y
   Kumbhare SV, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-11215-y
   Lee JK, 2020, BIORESOURCE TECHNOL, V298, DOI 10.1016/j.biortech.2019.122346
   Leshem A, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.01341
   Luo ZW, 2021, INT J NANOMED, V16, P2949, DOI 10.2147/IJN.S304515
   Maji A, 2018, ENVIRON MICROBIOL, V20, P402, DOI 10.1111/1462-2920.14015
   Masumoto S, 2016, SCI REP-UK, V6, DOI 10.1038/srep31208
   Milanovic V, 2020, INDIAN J MICROBIOL, V60, P115, DOI 10.1007/s12088-019-00817-x
   Naito Y, 2018, J CLIN BIOCHEM NUTR, V63, P33, DOI 10.3164/jcbn.18-57
   Nakanishi M, 2016, CANCER PREV RES, V9, P692, DOI 10.1158/1940-6207.CAPR-16-0026
   Ng KM, 2013, NATURE, V502, P96, DOI 10.1038/nature12503
   O'Keefe SJD, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms7342
   Patel SKS, 2020, INDIAN J MICROBIOL, V60, P263, DOI 10.1007/s12088-020-00893-4
   Petersson J, 2011, AM J PHYSIOL-GASTR L, V300, pG327, DOI 10.1152/ajpgi.00422.2010
   Pierre JF, 2016, AM J PHYSIOL-GASTR L, V311, pG286, DOI 10.1152/ajpgi.00202.2016
   Plovier H, 2017, NAT MED, V23, P107, DOI 10.1038/nm.4236
   Raffa CM, 2021, BIOENGINEERING-BASEL, V8, DOI 10.3390/bioengineering8070092
   Ridaura VK, 2013, SCIENCE, V341, P1079, DOI 10.1126/science.1241214
   Rishi P, 2020, INDIAN J MICROBIOL, V60, P420, DOI 10.1007/s12088-020-00908-0
   Roopchand DE, 2015, DIABETES, V64, P2847, DOI 10.2337/db14-1916
   Routy B, 2018, SCIENCE, V359, P91, DOI 10.1126/science.aan3706
   Rowland I, 2018, EUR J NUTR, V57, P1, DOI 10.1007/s00394-017-1445-8
   Schneeberger M, 2015, SCI REP-UK, V5, DOI 10.1038/srep16643
   Sender R, 2016, PLOS BIOL, V14, DOI 10.1371/journal.pbio.1002533
   Shen W, 2017, FRONT MICROBIOL, V8, P1, DOI 10.3389/fmicb.2017.00272
   Silva YP, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.00025
   Singhvi N, 2020, INDIAN J MICROBIOL, V60, P26, DOI 10.1007/s12088-019-00825-x
   Sood U, 2020, INDIAN J MICROBIOL, V60, P2, DOI 10.1007/s12088-019-00785-2
   Sood U, 2018, INDIAN J MICROBIOL, V58, P123, DOI 10.1007/s12088-018-0706-4
   Tu PC, 2018, ACS OMEGA, V3, P10927, DOI 10.1021/acsomega.8b00064
   Tuikhar N, 2019, MECH AGEING DEV, V179, P23, DOI [10.1016/j.mad.2019.02.001, 10.1016/j.mad.2019.02.00]
   Vallim TQD, 2013, CELL METAB, V17, P657, DOI 10.1016/j.cmet.2013.03.013
   van Nood E, 2013, NEW ENGL J MED, V368, P2145, DOI [10.1056/NEJMoa1205037, 10.1056/NEJMc1303919]
   Vrieze A, 2012, GASTROENTEROLOGY, V143, P913, DOI 10.1053/j.gastro.2012.06.031
   Wang YH, 2018, NAT MED, V24, P1804, DOI 10.1038/s41591-018-0238-9
   Weingarden AR, 2014, AM J PHYSIOL-GASTR L, V306, pG310, DOI 10.1152/ajpgi.00282.2013
   Weir TL, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0070803
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Zarrinpar A, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-018-05336-9
   Zhao SQ, 2017, J MOL ENDOCRINOL, V58, P1, DOI 10.1530/JME-16-0054
   Zhu L, 2018, ATHEROSCLEROSIS, V268, P117, DOI 10.1016/j.atherosclerosis.2017.11.023
NR 78
TC 15
Z9 15
U1 5
U2 24
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0046-8991
EI 0973-7715
J9 INDIAN J MICROBIOL
JI Indian J. Microbiol.
PD MAR
PY 2022
VL 62
IS 1
BP 1
EP 10
DI 10.1007/s12088-021-00993-9
EA DEC 2021
PG 10
WC Biotechnology & Applied Microbiology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Microbiology
GA YG3DG
UT WOS:000730884400001
PM 34931096
OA Green Published, Bronze
DA 2023-06-08
ER

PT J
AU Balvers, M
   van den Born, BJH
   Levin, E
   Nieuwdorp, M
AF Balvers, Manon
   van den Born, Bert-Jan H.
   Levin, Evgeni
   Nieuwdorp, Max
TI Impact drugs targeting cardiometabolic risk on the gut microbiota
SO CURRENT OPINION IN LIPIDOLOGY
LA English
DT Review
DE antihyperglycemic drugs; antihyperlipidemic drugs; antihypertensive
   drugs; drug; microbiome
ID INTESTINAL MICROBIOTA; DOUBLE-BLIND; METFORMIN; BIOAVAILABILITY;
   AMLODIPINE; ALTERS; TRIAL
AB Purpose of review Alterations in the gut microbiome composition or function are associated with risk factors for cardiometabolic diseases, including hypertension, hyperlipidemia and hyperglycemia. Based on recent evidence that also oral medications used to treat these conditions could alter the gut microbiome composition and function and, vice versa, that the gut microbiome could affect the efficacy of these treatments, we reviewed the literature on these observed interactions. Recent findings While the interaction of metformin with the gut microbiome has been studied most, other drugs that target cardiometabolic risk are gaining attention and often showed associations with alterations in microbiome-related features, including alterations in specific microbial taxa or pathways, microbiome composition or microbiome-derived metabolites, while the gut microbiome was also involved in drug metabolism and drug efficacy. As for metformin, for some of them even a potential therapeutic effect via the gut microbiome is postulated. However, exact mechanisms remain to be elucidated. There is growing interest in clarifying the interactions between the gut microbiome and drugs to treat hypertension, hyperlipidemia and hyperglycemia as well as the first pass effect of microbiome on drug efficacy. While mostly analysed in animal models, also human studies are gaining more and more traction. Improving the understanding of the gut microbiome drug interaction can provide clinical directions for therapy by optimizing drug efficacy or providing new targets for drug development.
C1 [Balvers, Manon; van den Born, Bert-Jan H.; Levin, Evgeni; Nieuwdorp, Max] Univ Amsterdam, Locat AMC, Amsterdam UMC, Dept Internal & Vasc Med, Amsterdam, Netherlands.
   [Balvers, Manon; Levin, Evgeni] Horaizon BV, Delft, Netherlands.
   [van den Born, Bert-Jan H.] Univ Amsterdam, Amsterdam UMC, Dept Publ Hlth, Amsterdam, Netherlands.
C3 University of Amsterdam; University of Amsterdam
RP Nieuwdorp, M (通讯作者)，Univ Amsterdam, Med Ctr, Amsterdam Diabet Ctr, Dept Internal & Vasc Med,Locat AMC, Meibergdreef 9,Room D3-211, NL-1105 AZ Amsterdam, Netherlands.
EM m.nieuwdorp@amster-damumc.nl
RI van den Born, Bert-Jan/E-4263-2017
OI van den Born, Bert-Jan H. (BJH)/0000-0003-0943-4393
FU NNF CAMIT grant 2018; Le Ducq consortium grant [17CVD01]
FX M.V. is appointed on a NNF CAMIT grant 2018 (to M.N.). The study
   reported here was additionally supported by Le Ducq consortium grant
   17CVD01 (to M.N.). The illustrations in the summary figure are from
   Servier Medical Art (smart.servier.com). M.B. is supported by a NNF
   CAMIT grant 2018.
CR Bailey CJ, 2017, DIABETOLOGIA, V60, P1566, DOI 10.1007/s00125-017-4318-z
   Brocker CN, 2020, HUM GENOMICS, V14, DOI 10.1186/s40246-020-00260-w
   Bronden A, 2018, DIABETES OBES METAB, V20, P1623, DOI 10.1111/dom.13272
   Bryrup T, 2019, DIABETOLOGIA, V62, P1024, DOI 10.1007/s00125-019-4848-7
   Catry E, 2015, LIFE SCI, V132, P77, DOI 10.1016/j.lfs.2015.04.004
   Chan YK, 2016, BMC MICROBIOL, V16, DOI 10.1186/s12866-016-0883-4
   Chavez-Carbajal A, 2020, MICROORGANISMS, V8, DOI 10.3390/microorganisms8010094
   Choi MS, 2018, PHARMACOL RES, V130, P164, DOI 10.1016/j.phrs.2018.01.019
   De Filippis F, 2019, CELL HOST MICROBE, V25, P444, DOI 10.1016/j.chom.2019.01.004
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Deschasaux M, 2018, NAT MED, V24, P1526, DOI 10.1038/s41591-018-0160-1
   Dias AM, 2020, PHARMACOL RES PERSPE, V8, DOI 10.1002/prp2.601
   Diener C, 2020, MSYSTEMS, V5, DOI 10.1128/mSystems.00606-19
   Ejtahed HS, 2019, EUR J ENDOCRINOL, V180, P165, DOI [10.1530/EJE-18-0826, 10.1530/eje-18-0826]
   Elbere I, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0204317
   Falony G, 2016, SCIENCE, V352, P560, DOI 10.1126/science.aad3503
   Fangmann D, 2018, DIABETES CARE, V41, P398, DOI 10.2337/dc17-1967
   Foretz M, 2019, NAT REV ENDOCRINOL, V15, P569, DOI 10.1038/s41574-019-0242-2
   Fuchs CD, 2018, GUT, V67, P1683, DOI 10.1136/gutjnl-2017-314553
   Gaike AH., 2020, MSYSTEMS, V5, P1
   Gonzalez FJ, 2016, GASTROENTEROLOGY, V151, P845, DOI 10.1053/j.gastro.2016.08.057
   Gu YY, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-01682-2
   Jackson MA, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-018-05184-7
   Jaworska K, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0189310
   Jie ZY, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-00900-1
   Kappel B, 2019, REV ENDOCR METAB DIS, V20, P399, DOI 10.1007/s11154-019-09533-9
   Khan TJ, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-017-19013-2
   Kim J, 2019, FRONT MICROBIOL, V10, DOI 10.3389/fmicb.2019.01947
   Koh A, 2020, CELL METAB, V32, P643, DOI 10.1016/j.cmet.2020.07.012
   Konop M, 2018, BIOMARKERS, V23, P380, DOI 10.1080/1354750X.2018.1432689
   Kummen M., 2020, SCI REP-UK, V10, P1
   Kurilshikov A, 2019, CIRC RES, V124, P1808, DOI 10.1161/CIRCRESAHA.118.314642
   Kusumoto Y, 2017, METABOLISM, V71, P1, DOI 10.1016/j.metabol.2017.02.011
   Kyriachenko Y, 2019, WORLD J DIABETES, V10, P154, DOI 10.4239/wjd.v10.i3.154
   Li HB, 2020, HYPERTENSION, V75, P1315, DOI 10.1161/HYPERTENSIONAHA.120.14736
   Li LY, 2020, MICROBIOME, V8, DOI 10.1186/s40168-020-00806-z
   Li LY, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-12087-8
   Lynch SV, 2016, NEW ENGL J MED, V375, P2369, DOI 10.1056/NEJMra1600266
   Maier L, 2018, NATURE, V555, P623, DOI 10.1038/nature25979
   Mishima E, 2018, AM J PHYSIOL-RENAL, V315, pF824, DOI 10.1152/ajprenal.00314.2017
   Nakajima H., 2020, LIFE, V10, P1
   Pryor R, 2019, CELL, V178, P1299, DOI 10.1016/j.cell.2019.08.003
   Pryor R, 2020, ANNU REV PHARMACOL, V60, P417, DOI 10.1146/annurev-pharmtox-010919-023612
   Qiu YX, 2020, DIABETOLOGIA, V63, P1002, DOI 10.1007/s00125-020-05095-7
   Robles-Vera I, 2020, BRIT J PHARMACOL, V177, P2006, DOI 10.1111/bph.14965
   Rodriguez J, 2018, CURR OPIN CLIN NUTR, V21, P294, DOI 10.1097/MCO.0000000000000468
   Ryan PM, 2017, MICROBIOME, V5, DOI 10.1186/s40168-017-0246-x
   Smits MM, 2016, DIABETES OBES METAB, V18, P1217, DOI 10.1111/dom.12748
   Song SC, 2017, BENEF MICROBES, V8, P801, DOI 10.3920/BM2016.0231
   Sudun, 2019, FOOD FUNCT, V10, P6098, DOI [10.1039/c9fo00444k, 10.1039/C9FO00444K]
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Nguyen TLA, 2015, DIS MODEL MECH, V8, P1, DOI 10.1242/dmm.017400
   Tsuji Y, 2020, MICROORGANISMS, V8, DOI 10.3390/microorganisms8060925
   van Bommel EJM, 2020, DIABETES METAB, V46, P164, DOI 10.1016/j.diabet.2019.11.005
   Verhaar BJH., 2020, EUR HEART J
   Verhaar BJH., 2020, NUTRIENTS, V12, P1
   Vieira-Silva S, 2020, NATURE, V581, P310, DOI 10.1038/s41586-020-2269-x
   Vila AV, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-019-14177-z
   Villette R, 2020, FRONT PHARMACOL, V11, DOI 10.3389/fphar.2020.00278
   Wang Zhang, 2018, Endocrinol Diabetes Metab, V1, pe00009, DOI 10.1002/edm2.9
   Warmbrunn MV, 2020, EXPERT REV ENDOCRINO, V15, P13, DOI 10.1080/17446651.2020.1720511
   Weersma RK, 2020, GUT, V69, P1510, DOI 10.1136/gutjnl-2019-320204
   Whang A, 2019, EBIOMEDICINE, V39, P591, DOI 10.1016/j.ebiom.2018.11.046
   Wu DD, 2019, BIOMED PHARMACOTHER, V116, DOI 10.1016/j.biopha.2019.109040
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Yang T, 2019, J AM HEART ASSOC, V8, DOI 10.1161/JAHA.118.010721
   Yoo HH, 2016, J HYPERTENS, V34, P156, DOI 10.1097/HJH.0000000000000773
   Zhang FH, 2019, ENDOCRINE, V66, P485, DOI 10.1007/s12020-019-02041-5
   Zhang JH, 2018, DRUG DELIV, V25, P1175, DOI 10.1080/10717544.2018.1469687
   Zhang Q, 2020, FRONT PHARMACOL, V11, DOI 10.3389/fphar.2020.00522
   Zhang X, 2021, GUT, V70, P761, DOI 10.1136/gutjnl-2019-319664
   Zhang XY, 2017, DIABETES THER, V8, P293, DOI 10.1007/s13300-017-0226-y
   Zhao C., 2020, PSYCHOL MONTHLY, V15, P1
   Zimmermann F, 2020, J CLIN MED, V9, DOI 10.3390/jcm9051596
   Zimmermann M, 2019, NATURE, V570, P462, DOI 10.1038/s41586-019-1291-3
   Zimmermann M, 2019, SCIENCE, V363, P600, DOI 10.1126/science.aat9931
NR 76
TC 0
Z9 0
U1 2
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0957-9672
EI 1473-6535
J9 CURR OPIN LIPIDOL
JI Curr. Opin. Lipidology
PD FEB
PY 2021
VL 32
IS 1
BP 38
EP 54
DI 10.1097/MOL.0000000000000727
PG 17
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism; Peripheral
   Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism;
   Cardiovascular System & Cardiology
GA SS8VG
UT WOS:000662030100005
PM 33332920
DA 2023-06-08
ER

PT J
AU Hur, KY
   Lee, MS
AF Hur, Kyu Yeon
   Lee, Myung-Shik
TI New mechanisms of metformin action: Focusing on mitochondria and the gut
SO JOURNAL OF DIABETES INVESTIGATION
LA English
DT Review
DE Autophagy; Gut; Mitochondria
ID THIOREDOXIN-INTERACTING PROTEIN; GLUCAGON-LIKE PEPTIDE-1; PANCREATIC
   BETA-CELLS; DIET-INDUCED OBESITY; GLUCOSE-HOMEOSTASIS; NLRP3
   INFLAMMASOME; OXIDATIVE STRESS; ER STRESS; INSULIN-RESISTANCE; C.
   ELEGANS
AB The most well-known mechanism of metformin action, one of the most commonly prescribed antidiabetic drugs, is adenosine monophosphate-activated protein kinase activation; however, recent investigations have shown that adenosine monophosphate-activated protein kinase-independent pathways can explain some of metformin's beneficial metabolic effects as well as undesirable side-effects. Such novel pathways include induction of mitochondrial stress, inhibition of mitochondrial shuttles, alteration of intestinal microbiota, suppression of glucagon signaling, activation of autophagy, attenuation of inflammasome activation, induction of incretin receptors and reduction of terminal endoplasmic reticulum stress. Together, these studies have broadened our understanding of the mechanisms of antidiabetic agents as well as the pathogenic mechanism of diabetes itself. The results of such investigations might help to identify new target molecules and pathways for treatment of diabetes and metabolic syndrome, and could also have broad implications in diseases other than diabetes. Accordingly, new antidiabetic drugs with better efficacy and fewer adverse effects will likely result from these studies.
C1 [Hur, Kyu Yeon; Lee, Myung-Shik] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Div Endocrinol & Metab,Dept Med, Seoul, South Korea.
C3 Sungkyunkwan University (SKKU); Samsung Medical Center
RP Lee, MS (通讯作者)，Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Div Endocrinol & Metab,Dept Med, Seoul, South Korea.
EM mslee0923@skku.edu
RI Lee, Myung Shik/C-9606-2011
OI Lee, Myung-Shik/0000-0003-3292-1720
FU Global Research Laboratory Grant of the National Research Foundation of
   Korea [K21004000003-10A0500-00310]; Ulsan National Institute of Science
   and Technology (UNIST) [2014M3A9D8034459]; National Research Foundation
   of Korea [2010-00347] Funding Source: Korea Institute of Science &
   Technology Information (KISTI), National Science & Technology
   Information Service (NTIS)
FX This work was supported by the Global Research Laboratory Grant of the
   National Research Foundation of Korea (K21004000003-10A0500-00310), and
   the Ulsan National Institute of Science and Technology (UNIST) research
   fund (2014M3A9D8034459). The authors thank Sungkab Kim (Samsung Medical
   Center, Multimedia Services Part, Chief Illustrator) for illustrating
   the figures.
CR Alhouayek M, 2012, TRENDS MOL MED, V18, P615, DOI 10.1016/j.molmed.2012.07.009
   Back SH, 2009, CELL METAB, V10, P13, DOI 10.1016/j.cmet.2009.06.002
   Backhed F, 2004, P NATL ACAD SCI USA, V101, P15718, DOI 10.1073/pnas.0407076101
   Backhed F, 2007, P NATL ACAD SCI USA, V104, P979, DOI 10.1073/pnas.0605374104
   Bailey CJ, 2008, DIABETOLOGIA, V51, P1552, DOI 10.1007/s00125-008-1053-5
   BAILEY CJ, 1994, BRIT J PHARMACOL, V112, P671, DOI 10.1111/j.1476-5381.1994.tb13128.x
   Barbato DL, 2013, CELL DEATH DIS, V4, DOI 10.1038/cddis.2013.404
   Baur JA, 2014, CELL METAB, V20, P197, DOI 10.1016/j.cmet.2014.07.013
   Buzzai M, 2007, CANCER RES, V67, P6745, DOI 10.1158/0008-5472.CAN-06-4447
   Cabreiro F, 2013, CELL, V153, P228, DOI 10.1016/j.cell.2013.02.035
   Chai TF, 2012, CELL SIGNAL, V24, P1700, DOI 10.1016/j.cellsig.2012.04.017
   Cho MH, 2014, AUTOPHAGY, V10, P1761, DOI 10.4161/auto.29647
   Derrien M, 2011, FRONT MICROBIOL, V2, DOI 10.3389/fmicb.2011.00166
   Dethlefsen L, 2008, PLOS BIOL, V6, P2383, DOI 10.1371/journal.pbio.0060280
   Egan DF, 2011, SCIENCE, V331, P456, DOI 10.1126/science.1196371
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Feuerer M, 2009, NAT MED, V15, P930, DOI 10.1038/nm.2002
   Foretz M, 2014, CELL METAB, V20, P953, DOI 10.1016/j.cmet.2014.09.018
   Foretz M, 2010, J CLIN INVEST, V120, P2355, DOI 10.1172/JCI40671
   Hardie DG, 2007, ANNU REV PHARMACOL, V47, P185, DOI 10.1146/annurev.pharmtox.47.120505.105304
   Hardie DG, 2001, BIOESSAYS, V23, P1112, DOI 10.1002/bies.10009
   Harding HP, 2003, MOL CELL, V11, P619, DOI 10.1016/S1097-2765(03)00105-9
   He CY, 2013, DIABETES, V62, P1270, DOI 10.2337/db12-0533
   He CC, 2012, NATURE, V481, P511, DOI 10.1038/nature10758
   Hildebrandt MA, 2009, GASTROENTEROLOGY, V137, P1716, DOI 10.1053/j.gastro.2009.08.042
   Hinke SA, 2007, BRIT J PHARMACOL, V150, P1031, DOI 10.1038/sj.bjp.0707189
   Hooper LV, 2012, SCIENCE, V336, P1268, DOI 10.1126/science.1223490
   HOTAMISLIGIL GS, 1993, SCIENCE, V259, P87, DOI 10.1126/science.7678183
   Houtkooper RH, 2013, NATURE, V497, P451, DOI 10.1038/nature12188
   Inzucchi SE, 2012, DIABETES CARE, V35, P1364, DOI 10.2337/dc12-0413
   Jiang YL, 2014, INT J BIOL SCI, V10, P268, DOI 10.7150/ijbs.7929
   Kalender A, 2010, CELL METAB, V11, P390, DOI 10.1016/j.cmet.2010.03.014
   Kim DH, 2012, DIABETOLOGIA, V55, P3308, DOI 10.1007/s00125-012-2723-x
   Kim J, 2014, J CLIN INVEST, V124, P3311, DOI 10.1172/JCI69625
   Kim J, 2013, CELL, V152, P290, DOI 10.1016/j.cell.2012.12.016
   Kim J, 2011, NAT CELL BIOL, V13, P132, DOI 10.1038/ncb2152
   Kim KH, 2014, NAT REV ENDOCRINOL, V10, P322, DOI 10.1038/nrendo.2014.35
   Kim KH, 2013, BIOCHEM BIOPH RES CO, V440, P76, DOI 10.1016/j.bbrc.2013.09.026
   Kim KH, 2013, NAT MED, V19, P83, DOI 10.1038/nm.3014
   Kim MH, 2014, J ENDOCRINOL, V220, P117, DOI 10.1530/JOE-13-0381
   KLIP A, 1990, DIABETES CARE, V13, P696, DOI 10.2337/diacare.13.6.696
   Kufer TA, 2011, NAT IMMUNOL, V12, P121, DOI 10.1038/ni.1985
   Larsen CM, 2007, NEW ENGL J MED, V356, P1517, DOI 10.1056/NEJMoa065213
   Le Chatelier E, 2013, NATURE, V500, P541, DOI 10.1038/nature12506
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Lee HM, 2013, DIABETES, V62, P194, DOI 10.2337/db12-0420
   Lerner AG, 2012, CELL METAB, V16, P250, DOI 10.1016/j.cmet.2012.07.007
   Ley RE, 2005, P NATL ACAD SCI USA, V102, P11070, DOI 10.1073/pnas.0504978102
   Lim YM, 2014, NAT COMMUN, V5, DOI 10.1038/ncomms5934
   Liou AP, 2013, SCI TRANSL MED, V5, DOI 10.1126/scitranslmed.3005687
   Madiraju AK, 2014, NATURE, V510, P542, DOI 10.1038/nature13270
   Maida A, 2011, DIABETOLOGIA, V54, P339, DOI 10.1007/s00125-010-1937-z
   Mannucci E, 2004, DIABETES NUTR METAB, V17, P336
   Mannucci E, 2001, DIABETES CARE, V24, P489, DOI 10.2337/diacare.24.3.489
   Maratos-Flier E, 2013, NAT MED, V19, P1218, DOI 10.1038/nm.3373
   Martin-Montalvo A, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms3192
   Masini M, 2009, DIABETOLOGIA, V52, P1083, DOI 10.1007/s00125-009-1347-2
   Masters SL, 2010, NAT IMMUNOL, V11, P897, DOI 10.1038/ni.1935
   Miller RA, 2013, NATURE, V494, P256, DOI 10.1038/nature11808
   Misawa T, 2013, NAT IMMUNOL, V14, P454, DOI 10.1038/ni.2550
   Mizushima N, 2011, CELL, V147, P728, DOI 10.1016/j.cell.2011.10.026
   Mouchiroud L, 2013, CELL, V154, P430, DOI 10.1016/j.cell.2013.06.016
   Mulherin AJ, 2011, ENDOCRINOLOGY, V152, P4610, DOI 10.1210/en.2011-1485
   Nakahira K, 2011, NAT IMMUNOL, V12, P222, DOI 10.1038/ni.1980
   Ozcan U, 2006, SCIENCE, V313, P1137, DOI 10.1126/science.1128294
   Onken B, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0008758
   Oslowski CM, 2012, CELL METAB, V16, P265, DOI 10.1016/j.cmet.2012.07.005
   Owen MR, 2000, BIOCHEM J, V348, P607, DOI 10.1042/0264-6021:3480607
   Pearce EL, 2009, NATURE, V460, P103, DOI 10.1038/nature08097
   Petersen KF, 2003, SCIENCE, V300, P1140, DOI 10.1126/science.1082889
   Pospisilik JA, 2003, DIABETES, V52, P741, DOI 10.2337/diabetes.52.3.741
   Pyo JO, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms3300
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Scheuner D, 2005, NAT MED, V11, P757, DOI 10.1038/nm1259
   Shaked M, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0028804
   Shan MM, 2013, SCIENCE, V342, P447, DOI 10.1126/science.1237910
   Shaw RJ, 2005, SCIENCE, V310, P1642, DOI 10.1126/science.1120781
   Shi CS, 2012, NAT IMMUNOL, V13, P255, DOI 10.1038/ni.2215
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Singh R, 2009, NATURE, V458, P1131, DOI 10.1038/nature07976
   Song YM, 2015, AUTOPHAGY, V11, P46, DOI 10.4161/15548627.2014.984271
   Spuss A, 2012, LAB INVEST, V92, P1020
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Vandanmagsar B, 2011, NAT MED, V17, P179, DOI 10.1038/nm.2279
   Verfaillie T, 2012, CELL DEATH DIFFER, V19, P1880, DOI 10.1038/cdd.2012.74
   Wen HT, 2011, NAT IMMUNOL, V12, P408, DOI 10.1038/ni.2022
   Whitman WB, 1998, P NATL ACAD SCI USA, V95, P6578, DOI 10.1073/pnas.95.12.6578
   Witters LA, 2001, J CLIN INVEST, V108, P1105, DOI 10.1172/JCI14178
   Wu J, 2013, ENDOCRINE, V44, P87, DOI 10.1007/s12020-012-9826-5
   Xie ZL, 2011, DIABETES, V60, P1770, DOI 10.2337/db10-0351
   Yee C, 2014, CELL, V157, P897, DOI 10.1016/j.cell.2014.02.055
   Youm YH, 2011, ENDOCRINOLOGY, V152, P4039, DOI 10.1210/en.2011-1326
   Zhou GC, 2001, J CLIN INVEST, V108, P1167, DOI 10.1172/JCI200113505
   Zhou RB, 2010, NAT IMMUNOL, V11, P136, DOI 10.1038/ni.1831
NR 94
TC 119
Z9 123
U1 0
U2 44
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2040-1124
J9 J DIABETES INVEST
JI J. Diabetes Investig.
PD NOV
PY 2015
VL 6
IS 6
BP 600
EP 609
DI 10.1111/jdi.12328
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CU7AL
UT WOS:000363687000002
PM 26543531
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Deng, WL
   Ke, HR
   Wang, SQ
   Li, ZT
   Li, ST
   Lv, PJ
   Li, F
   Chen, Y
AF Deng, Wenlin
   Ke, Haoran
   Wang, Siqi
   Li, Zitong
   Li, Sitao
   Lv, Pinjing
   Li, Fang
   Chen, Ye
TI Metformin Alleviates Autistic-Like Behaviors Elicited by High-Fat Diet
   Consumption and Modulates the Crosstalk Between Serotonin and Gut
   Microbiota in Mice
SO BEHAVIOURAL NEUROLOGY
LA English
DT Article
ID BTBR MOUSE MODEL; DISORDERS; DEPRESSION; PROBIOTICS; OBESITY
AB The biological mechanisms linking diet-related obesity and autistic behaviors remain unclear. Metformin has proven to be beneficial in the treatment of many syndromes, including autism spectrum disorder. Therefore, the aim of this study was to assess whether metformin treatment could ameliorate metabolic and behavioral alterations in C57BL/6 mice kept on a high-fat diet (HFD), and whether these changes were related to modifications in the gut microbiota and 5-HT levels. As expected, ten weeks of HFD ingestion increased body weight, adiposity, and glucose levels. HFD-fed mice showed a marked aggravation of repetitive behaviors (marble burying and self-grooming), and this was prevented by metformin administration. In addition, HFD-fed mice increased the total distance travelled in the open field test. This hyperactivity was counteracted by metformin cotreatment. In the elevated plus maze test, HFD-fed mice showed a reduced number of entries into the open arms. Interestingly, both HFD and metformin cotreatment increased social interactions in the three-chamber test. HFD increased the levels of intestinal tryptophan and 5-hydroxyindoleacetic acid. Metformin stimulated gut tryptophan and promoted the synthesis of 5-HT in the HFD group. Lactococcus, Trichococcus, Romboutsia, and Faecalibaculum were enriched in HFD-fed mice, whereas the HFD group cotreated with metformin was enriched in Intestinimonas and L. reuteri. Faecalibacterium was positively correlated with sociability and 5-HT pathway components in mice that received metformin. In summary, HFD consumption elicited a complex phenotype comprising higher levels of anxiety-like and repetitive behaviors but also increased sociability. Metformin could potentially improve HFD-induced disorders in the autistic spectrum through a mechanism involving positive modulation of 5-HT levels in the gut and its microbiota composition.
C1 [Deng, Wenlin; Ke, Haoran; Wang, Siqi; Li, Zitong; Chen, Ye] Southern Med Univ, Nanfang Hosp, Dept Gastroenterol, State Key Lab Organ Failure Res, Guangzhou 510515, Guangdong, Peoples R China.
   [Deng, Wenlin; Li, Sitao; Lv, Pinjing] Sun Yat Sen Univ, Affiliated Hosp 6, Dept Pediat, Guangzhou 510655, Peoples R China.
   [Li, Fang] Hainan Med Univ, Hainan Affiliated Hosp, Hainan Gen Hosp, Gastroenterol Endoscopy Ctr,Dept Gastroenterol, Haikou 570311, Hainan, Peoples R China.
C3 Southern Medical University - China; Sun Yat Sen University; Hainan
   Medical University
RP Chen, Y (通讯作者)，Southern Med Univ, Nanfang Hosp, Dept Gastroenterol, State Key Lab Organ Failure Res, Guangzhou 510515, Guangdong, Peoples R China.; Li, F (通讯作者)，Hainan Med Univ, Hainan Affiliated Hosp, Hainan Gen Hosp, Gastroenterol Endoscopy Ctr,Dept Gastroenterol, Haikou 570311, Hainan, Peoples R China.
EM dengwl3@mail.sysu.edu.cn; kehaoran@smu.edu.cn; wsq21600242@smu.edu.cn;
   1223978306@qq.com; lisit@mail.sysu.edu.cn; 779711485@qq.com;
   1195948845@qq.com; yechen@smu.edu.cn
FU National Natural Science Foundation of China [81770529, 82100609];
   Science and Technology Foundation of Guangzhou, China [202103000071];
   Hainan Provincial Natural Science Foundation of China [821QN0982];
   Guangdong Gastrointestinal Disease Research Center [2017B02029003]
FX AcknowledgmentsThis work was supported by the National Natural Science
   Foundation of China (grant numbers 81770529 and 82100609), the Science
   and Technology Foundation of Guangzhou, China (202103000071), the Hainan
   Provincial Natural Science Foundation of China (No. 821QN0982), and the
   Guangdong Gastrointestinal Disease Research Center (grant number
   2017B02029003).
CR American Psychiatric Association, 2022, DIAGNOSTIC STAT MANU, V5th
   Anderson SE, 2006, ARCH PEDIAT ADOL MED, V160, P285, DOI 10.1001/archpedi.160.3.285
   Angoa-Perez Mariana, 2013, J Vis Exp, P50978, DOI 10.3791/50978
   Arika WM, 2019, BEHAV NEUROL, V2019, DOI 10.1155/2019/7359235
   Banskota S, 2019, BIOCHIMIE, V161, P56, DOI 10.1016/j.biochi.2018.06.008
   Bhupathiraju SN, 2016, CIRC RES, V118, P1723, DOI 10.1161/CIRCRESAHA.115.306825
   Clarke G, 2013, MOL PSYCHIATR, V18, P666, DOI 10.1038/mp.2012.77
   Cryan JF, 2019, PHYSIOL REV, V99, P1877, DOI 10.1152/physrev.00018.2018
   Deng J, 2018, J CELL MOL MED, V22, P546, DOI 10.1111/jcmm.13342
   Eudave DM, 2018, NEUROBIOL STRESS, V9, P1, DOI 10.1016/j.ynstr.2018.05.005
   Fattorusso A, 2019, NUTRIENTS, V11, DOI 10.3390/nu11030521
   Foley KP, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-018-07146-5
   Gantois I, 2017, NAT MED, V23, P674, DOI 10.1038/nm.4335
   Garbarino VR, 2019, PHARMACOL RES, V140, P21, DOI 10.1016/j.phrs.2018.11.013
   Hassan AM, 2019, NUTR NEUROSCI, V22, P877, DOI 10.1080/1028415X.2018.1465713
   Israelyan N, 2018, PHARMACOL RES, V132, P1, DOI 10.1016/j.phrs.2018.03.020
   Jeong MY, 2019, NEUROSCI LETT, V698, P51, DOI 10.1016/j.neulet.2019.01.006
   Ji SQ, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00704
   Kaidanovich-Beilin O, 2011, JOVE-J VIS EXP, DOI 10.3791/2473
   Krishna S, 2016, PHYSIOL BEHAV, V157, P196, DOI 10.1016/j.physbeh.2016.02.007
   Lyte M, 2011, BIOESSAYS, V33, P574, DOI 10.1002/bies.201100024
   Ma W, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.01336
   Magne F, 2020, NUTRIENTS, V12, DOI 10.3390/nu12051474
   Mawe GM, 2013, NAT REV GASTRO HEPAT, V10, P473, DOI 10.1038/nrgastro.2013.105
   McCreight LJ, 2016, DIABETOLOGIA, V59, P426, DOI 10.1007/s00125-015-3844-9
   Muller CL, 2016, NEUROSCIENCE, V321, P24, DOI 10.1016/j.neuroscience.2015.11.010
   Nagy C, 2018, JOVE-J VIS EXP, DOI 10.3791/56672
   O'Connor R, 2021, BEHAV BRAIN RES, V399, DOI 10.1016/j.bbr.2020.113020
   Pan Q, 2019, METAB BRAIN DIS, V34, P747, DOI 10.1007/s11011-019-0392-x
   Penagarikano O, 2011, CELL, V147, P235, DOI 10.1016/j.cell.2011.08.040
   Rajan TM, 2017, J POSTGRAD MED, V63, P182, DOI 10.4103/jpgm.JPGM_712_16
   Reichelt AC, 2019, FOOD FUNCT, V10, P1985, DOI [10.1039/C8FO02118J, 10.1039/c8fo02118j]
   Sarkar A, 2020, BIOL REV, V95, P1131, DOI 10.1111/brv.12603
   Sgritta M, 2019, NEURON, V101, P246, DOI 10.1016/j.neuron.2018.11.018
   Silverman JL, 2013, NEUROPHARMACOLOGY, V68, P210, DOI 10.1016/j.neuropharm.2012.07.042
   Steenbergen L, 2015, BRAIN BEHAV IMMUN, V48, P258, DOI 10.1016/j.bbi.2015.04.003
   Sweeney P, 2017, INT J OBESITY, V41, P1237, DOI 10.1038/ijo.2017.112
   Takase K, 2016, OBESITY, V24, P886, DOI 10.1002/oby.21441
   Tanokashira D, 2018, FEBS OPEN BIO, V8, P1104, DOI 10.1002/2211-5463.12436
   Terzo S, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21010365
   Tillisch K, 2013, GASTROENTEROLOGY, V144, P1394, DOI 10.1053/j.gastro.2013.02.043
   Walsh JJ, 2021, NEUROPSYCHOPHARMACOL, V46, P2000, DOI 10.1038/s41386-021-01091-6
   Walsh JJ, 2018, NATURE, V560, P589, DOI 10.1038/s41586-018-0416-4
   Zemdegs J, 2016, BRIT J PHARMACOL, V173, P2095, DOI 10.1111/bph.13343
   Zhang WQ, 2015, NEUROPHARMACOLOGY, V90, P1, DOI 10.1016/j.neuropharm.2014.10.024
   Zilkha N, 2017, NEUROSCIENCE, V345, P142, DOI 10.1016/j.neuroscience.2016.01.070
NR 46
TC 8
Z9 8
U1 4
U2 10
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 0953-4180
EI 1875-8584
J9 BEHAV NEUROL
JI Behav. Neurol.
PD FEB 17
PY 2022
VL 2022
AR 6711160
DI 10.1155/2022/6711160
PG 15
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA ZO8QA
UT WOS:000765991500001
PM 35222739
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Ansari, A
   Bose, S
   Lim, SK
   Wang, JH
   Choi, YH
   Kim, H
AF Ansari, AbuZar
   Bose, Shambhunath
   Lim, Soo-Kyoung
   Wang, Jing-Hua
   Choi, Young-Hee
   Kim, Hojun
TI Combination of Scutellaria baicalensis and Metformin Ameliorates
   Diet-Induced Metabolic Dysregulation in Mice via the Gut-Liver-Brain
   Axis
SO AMERICAN JOURNAL OF CHINESE MEDICINE
LA English
DT Article
DE Scutellaria baicalensis; Metformin; Metabolic Dysregulation; Microbiota
ID HIGH-FAT; HEPATIC STEATOSIS; INSULIN-RESISTANCE; FOOD-INTAKE;
   INFLAMMATION; FRUCTOSE; PATHWAY; GLUCOSE; GAMMA; RATS
AB Scutellaria baicalensis (SB), a herbal medicine, is commonly used to treat metabolic diseases, while Metformin (MF) is a widely used drug for type 2 diabetes. The purpose of this study was to investigate whether co-treatment of SB with MF could produce a potential therapeutic effect on high-fat and high-fructose diet (HFFD)-induced metabolic dysregulation. First, we optimized the dose of SB (100, 200, 400, and 800 mg/kg) with MF (200 mg/kg) in HFFD-induced C57BL6J mice. Next, the optimized dose of SB (400 mg/kg) was co-administered with MF (50, 100, and 200 mg/kg) in a similar animal model to find the effective combinations of SB and MF. Metabolic markers were determined in serum and tissues using different assays, histology, gene expression, and gut microbial population. The SB and MF co-treatment significantly decreased the body, liver, and VAT weights. The outcome of OGTT was improved, and the fasting insulin, HbA1c, TG, TC, LDL-c, AST, and ALT were decreased, while HDL-c was significantly increased. Histological analyses revealed maintained the integrity of liver, adipose tissue, and intestine prevented lipid accumulation in the liver and intestine and combated neuronal damage in the brain. Importantly, controlled the expression of PPAR gamma, and IL-6 genes in the liver, and expression of BDNF, Glut1, Glut3, and Glut4 genes in the brain. Treatment-specific gut microbial segregation was observed in the PCA chart. Our findings indicate that SB and MF co-treatment is an effective therapeutic approach for HFFD-induced metabolic dysregulation which is operated through the gut-liver-brain axis.
C1 [Ansari, AbuZar] Ewha Womans Univ, Mokdong Hosp, Dept Obstet & Gynecol, Seoul, South Korea.
   [Bose, Shambhunath] NosQuest Inc, USPACE 1A-1103,Daewang Pangyo Ro 660, Seongnam Si 13494, Gyeonggi Do, South Korea.
   [Wang, Jing-Hua] Daejeon Univ, Coll Korean Med, Dept Immunol, Inst Biosci & Integrat Med, Daejeon, South Korea.
   [Choi, Young-Hee] Dongguk Univ Seoul, Coll Pharm, Goyang, South Korea.
   [Choi, Young-Hee] Dongguk Univ Seoul, Integrated Res Inst Drug Dev, Goyang, South Korea.
   [Ansari, AbuZar; Lim, Soo-Kyoung; Kim, Hojun] Dongguk Univ, Dept Rehabil Med Korean Med, Goyang Si, South Korea.
C3 Ewha Womans University; Daejeon University; Dongguk University; Dongguk
   University; Dongguk University
RP Kim, H (通讯作者)，Dongguk Univ, Dept Rehabil Med Korean Med, Med Ctr, Goyang Si 10326, Gyeonggi Do, South Korea.
EM kimklar@dongguk.ac.kr
RI Wang, Jing-hua/AAO-2350-2020; Bose, Shambhunath/HKW-2568-2023
OI Wang, Jing-hua/0000-0002-2034-7429; Choi, Young Hee/0000-0002-9360-6436
FU Convergence of Conventional Medicine and Traditional Medicine Korean
   Medicine R&D - Ministry of Health and Welfare through the Korean Health
   Industry Development Institute [HI14C0558]
FX This work was supported by a Convergence of Conventional Medicine and
   Traditional Medicine Korean Medicine R&D grant funded by the Ministry of
   Health and Welfare through the Korean Health Industry Development
   Institute (HI14C0558).
CR Agusti A, 2018, FRONT NEUROSCI-SWITZ, V12, DOI 10.3389/fnins.2018.00155
   Anderson RA, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0083243
   Ansari A, 2016, MOLECULES, V21, DOI 10.3390/molecules21111522
   Bak EJ, 2014, CLIN NUTR, V33, P156, DOI 10.1016/j.clnu.2013.03.013
   Bosi E, 2009, DIABETES OBES METAB, V11, P3, DOI 10.1111/j.1463-1326.2008.01031.x
   Bouchoucha M, 2011, DIABETES METAB, V37, P90, DOI 10.1016/j.diabet.2010.11.002
   BROWN MS, 1986, SCIENCE, V232, P34, DOI 10.1126/science.3513311
   Coate KC, 2010, AM J PHYSIOL-ENDOC M, V299, pE887, DOI 10.1152/ajpendo.00372.2010
   Cotillard A, 2013, NATURE, V500, P585, DOI 10.1038/nature12480
   Dekker MJ, 2010, AM J PHYSIOL-ENDOC M, V299, pE685, DOI 10.1152/ajpendo.00283.2010
   Dong J, 2015, INT CONF MACH LEARN, P14, DOI 10.1109/ICMLC.2015.7340890
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   GOLDSTEIN JL, 1990, NATURE, V343, P425, DOI 10.1038/343425a0
   Guo HX, 2009, ACTA PHARMACOL SIN, V30, P1505, DOI 10.1038/aps.2009.150
   Han K, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0182467
   Hariri N, 2010, NUTR RES REV, V23, P270, DOI 10.1017/S0954422410000168
   Henkel J, 1999, FDA Consum, V33, P12
   Holman R, 2007, Journ Annu Diabetol Hotel Dieu, P13
   Homma Yasuhiko, 2004, J Atheroscler Thromb, V11, P265
   Huang WH, 2006, BIOSCI BIOTECH BIOCH, V70, P2371, DOI 10.1271/bbb.50698
   Inoue M, 2005, BIOCHEM BIOPH RES CO, V336, P215, DOI 10.1016/j.bbrc.2005.08.070
   JACKSON RA, 1987, DIABETES, V36, P632, DOI 10.2337/diabetes.36.5.632
   Jo YH, 2013, DIABETES, V62, P1367, DOI 10.2337/db12-1824
   Kim EH, 2009, J ETHNOPHARMACOL, V126, P320, DOI 10.1016/j.jep.2009.08.027
   Kothari V, 2017, BBA-MOL BASIS DIS, V1863, P499, DOI 10.1016/j.bbadis.2016.10.006
   Kumar P, 2006, J PHYSIOL-LONDON, V574, P3, DOI 10.1113/jphysiol.2006.113704
   Lebrun B, 2006, AUTON NEUROSCI-BASIC, V126, P30, DOI 10.1016/j.autneu.2006.02.027
   Marcoux C, 1998, ATHEROSCLEROSIS, V139, P161, DOI 10.1016/S0021-9150(98)00042-2
   Moller DE, 2005, ANNU REV MED, V56, P45, DOI 10.1146/annurev.med.56.082103.104751
   Morton GJ, 2006, NATURE, V443, P289, DOI 10.1038/nature05026
   Na HY, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20030727
   Okazaki Y, 2016, FOOD SCI BIOTECHNOL, V25, P153, DOI 10.1007/s10068-016-0112-9
   Popkin BM, 2015, CURR DIABETES REP, V15, DOI 10.1007/s11892-015-0631-4
   Pratt DS, 2000, NEW ENGL J MED, V342, P1266, DOI 10.1056/NEJM200004273421707
   Schroeder B, 2016, NAT MED, V22, P1079, DOI 10.1038/nm.4185
   Seo MJ, 2014, FOOD CHEM TOXICOL, V67, P57, DOI 10.1016/j.fct.2014.02.009
   Shankar S., 2012, NUTR DIET CANC
   Song KH, 2013, PHYTOTHER RES, V27, P244, DOI 10.1002/ptr.4691
   Sowndhararajan K, 2018, BRAIN SCI, V8, DOI 10.3390/brainsci8060104
   Spady D.K., 1992, HEPATIC CLEARANCE PL
   Tilg H, 2008, TRENDS ENDOCRIN MET, V19, P371, DOI 10.1016/j.tem.2008.08.005
   Vallee A, 2018, FRONT IMMUNOL, V9, DOI 10.3389/fimmu.2018.00745
   Wada T, 2010, ENDOCRINOLOGY, V151, P2040, DOI 10.1210/en.2009-0869
   Waisundara VY, 2008, AM J CHINESE MED, V36, P517, DOI 10.1142/S0192415X08005953
   Wang H., 2018, ONCOTARGET, V9, P10135, DOI [10.18632/oncotarget, DOI 10.18632/ONCOTARGET.20807]
   Wang J, 2014, PLOS ONE, V9, DOI [10.1371/journal.pone.0101358, 10.1371/journal.pone.0086117]
   Wang JH, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00620
   Wang JH, 2017, GENES-BASEL, V8, DOI 10.3390/genes8100239
   Ye F, 2002, J ALTERN COMPLEM MED, V8, P567, DOI 10.1089/107555302320825075
   Yu CH, 2013, PHARM BIOL, V51, P1228, DOI 10.3109/13880209.2013.784922
NR 50
TC 6
Z9 6
U1 1
U2 14
PU WORLD SCIENTIFIC PUBL CO PTE LTD
PI SINGAPORE
PA 5 TOH TUCK LINK, SINGAPORE 596224, SINGAPORE
SN 0192-415X
EI 1793-6853
J9 AM J CHINESE MED
JI Am. J. Chin. Med.
PY 2020
VL 48
IS 6
BP 1409
EP 1433
DI 10.1142/S0192415X2050069X
PG 25
WC Integrative & Complementary Medicine; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine; General & Internal Medicine
GA NZ8EI
UT WOS:000577334500008
PM 32907360
DA 2023-06-08
ER

PT J
AU Sorrenti, V
   Benedetti, F
   Buriani, A
   Fortinguerra, S
   Caudullo, G
   Davinelli, S
   Zella, D
   Scapagnini, G
AF Sorrenti, Vincenzo
   Benedetti, Francesca
   Buriani, Alessandro
   Fortinguerra, Stefano
   Caudullo, Giada
   Davinelli, Sergio
   Zella, Davide
   Scapagnini, Giovanni
TI Immunomodulatory and Antiaging Mechanisms of Resveratrol, Rapamycin, and
   Metformin: Focus on mTOR and AMPK Signaling Networks
SO PHARMACEUTICALS
LA English
DT Review
DE resveratrol; rapamycin; metformin; AMPK; mTOR; immunosenescence; aging;
   immunomodulators; signaling pathways; immunity
ID T-LYMPHOCYTE SUBPOPULATIONS; ACTIVATED PROTEIN-KINASE;
   CAENORHABDITIS-ELEGANS; INNATE IMMUNITY; C. ELEGANS; LIFE-SPAN;
   CELL-ACTIVATION; GUT MICROBIOTA; OLD DRUG; CANCER
AB Aging results from the progressive dysregulation of several molecular pathways and mTOR and AMPK signaling have been suggested to play a role in the complex changes in key biological networks involved in cellular senescence. Moreover, multiple factors, including poor nutritional balance, drive immunosenescence progression, one of the meaningful aspects of aging. Unsurprisingly, nutraceutical and pharmacological interventions could help maintain an optimal biological response by providing essential bioactive micronutrients required for the development, maintenance, and the expression of the immune response at all stages of life. In this regard, many studies have provided evidence of potential antiaging properties of resveratrol, as well as rapamycin and metformin. Indeed, in vitro and in vivo models have demonstrated for these molecules a number of positive effects associated with healthy aging. The current review focuses on the mechanisms of action of these three important compounds and their suggested use for the clinical treatment of immunosenescence and aging.
C1 [Sorrenti, Vincenzo] Univ Padua, Dept Pharmaceut & Pharmacol Sci, Largo Egidio Meneghetti 2, I-35131 Padua, Italy.
   [Sorrenti, Vincenzo; Caudullo, Giada] Bendessere Study Ctr, Via Prima Str 23-3, I-35129 Padua, Italy.
   [Sorrenti, Vincenzo] Synlab Ltd, Data Med Grp, Maria Paola Belloni Ctr Personalized Med, I-35100 Padua, Italy.
   [Benedetti, Francesca; Buriani, Alessandro; Zella, Davide] Univ Maryland, Inst Human Virol, Dept Biochem & Mol Biol, Sch Med, Baltimore, MD 21201 USA.
   [Fortinguerra, Stefano] IRCCS SDN, Via E Gianturco 113, I-80143 Naples, Italy.
   [Davinelli, Sergio; Scapagnini, Giovanni] Univ Molise, Dept Med & Hlth Sci V Tiberio, I-86100 Campobasso, Italy.
C3 University of Padua; University System of Maryland; University of
   Maryland Baltimore; IRCCS Istituto di Ricerca Diagnostica e Nucleare
   (SDN); University of Molise
RP Sorrenti, V (通讯作者)，Univ Padua, Dept Pharmaceut & Pharmacol Sci, Largo Egidio Meneghetti 2, I-35131 Padua, Italy.; Sorrenti, V (通讯作者)，Bendessere Study Ctr, Via Prima Str 23-3, I-35129 Padua, Italy.; Sorrenti, V (通讯作者)，Synlab Ltd, Data Med Grp, Maria Paola Belloni Ctr Personalized Med, I-35100 Padua, Italy.; Zella, D (通讯作者)，Univ Maryland, Inst Human Virol, Dept Biochem & Mol Biol, Sch Med, Baltimore, MD 21201 USA.; Scapagnini, G (通讯作者)，Univ Molise, Dept Med & Hlth Sci V Tiberio, I-86100 Campobasso, Italy.
EM vincenzosorrenti88@gmail.com; fbenedetti@ihv.umaryland.edu;
   alessandro.buriani@gmail.com; stefano.fortinguerra@gmail.com;
   giada.caudullo@solgar.it; sergio.davinelli@unimol.it;
   dzella@ihv.umaryland.edu; giovanni.scapagnini@unimol.it
RI Sorrenti, Vincenzo/AAI-1683-2020; Fortinguerra, Stefano/AAA-4663-2021;
   DAVINELLI, SERGIO/U-1545-2017
OI Sorrenti, Vincenzo/0000-0002-4716-7401; Fortinguerra,
   Stefano/0000-0002-6111-332X; SCAPAGNINI, Giovanni/0000-0003-1592-5586;
   DAVINELLI, SERGIO/0000-0003-2578-7199; buriani,
   alessandro/0000-0001-9742-8991
CR Aballay A, 2002, CURR OPIN MICROBIOL, V5, P97, DOI 10.1016/S1369-5274(02)00293-X
   Aballay A, 2003, CURR BIOL, V13, P47, DOI 10.1016/S0960-9822(02)01396-9
   Aiello A, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.02247
   Algire C, 2012, CANCER PREV RES, V5, P536, DOI 10.1158/1940-6207.CAPR-11-0536
   Anisimov VN, 2008, CELL CYCLE, V7, P2769, DOI 10.4161/cc.7.17.6625
   Apelo SIA, 2016, J GERONTOL A-BIOL, V71, P841, DOI 10.1093/gerona/glw090
   Arrieta O, 2016, BMC CANCER, V16, DOI 10.1186/s12885-016-2658-6
   Baur JA, 2006, NATURE, V444, P337, DOI 10.1038/nature05354
   Benedetti F, 2020, VIRUSES-BASEL, V12, DOI 10.3390/v12121458
   Berman AY, 2017, NPJ PRECIS ONCOL, V1, DOI 10.1038/s41698-017-0038-6
   Bhullar KS, 2015, BBA-MOL BASIS DIS, V1852, P1209, DOI 10.1016/j.bbadis.2015.01.012
   BIERER BE, 1990, P NATL ACAD SCI USA, V87, P9231, DOI 10.1073/pnas.87.23.9231
   Bjedov I, 2020, GENES-BASEL, V11, DOI 10.3390/genes11091043
   Blagih J, 2015, IMMUNITY, V42, P41, DOI 10.1016/j.immuni.2014.12.030
   Blagosklonny MV, 2006, CELL CYCLE, V5, P2087, DOI 10.4161/cc.5.18.3288
   Blagosklonny MV, 2020, AGING-US, V12, P10004, DOI 10.18632/aging.103493
   Blagosklonny MV, 2019, CELL DEATH DIS, V10, DOI 10.1038/s41419-019-1822-8
   Boocock DJ, 2007, J CHROMATOGR B, V848, P182, DOI 10.1016/j.jchromb.2006.10.017
   Breuss JM, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20071523
   Bridges HR, 2016, BMC BIOL, V14, DOI 10.1186/s12915-016-0287-9
   Bridges HR, 2014, BIOCHEM J, V462, P475, DOI 10.1042/BJ20140620
   Brunkwall L, 2017, DIABETOLOGIA, V60, P943, DOI 10.1007/s00125-017-4278-3
   Burns J, 2002, J AGR FOOD CHEM, V50, P3337, DOI 10.1021/jf0112973
   Cabreiro F, 2013, CELL, V153, P228, DOI 10.1016/j.cell.2013.02.035
   Cai Y, 2014, MBIO, V5, DOI 10.1128/mBio.01235-14
   Cardona F, 2013, J NUTR BIOCHEM, V24, P1415, DOI 10.1016/j.jnutbio.2013.05.001
   Carter LG, 2014, ENDOCR-RELAT CANCER, V21, pR209, DOI 10.1530/ERC-13-0171
   Cha JH, 2018, MOL CELL, V71, P606, DOI 10.1016/j.molcel.2018.07.030
   Chang J Y, 1991, Br J Rheumatol, V30 Suppl 2, P62
   Chen J, 2017, ELIFE, V6, DOI 10.7554/eLife.31268
   Chen KL, 2020, AGING-US, V12, P3993, DOI 10.18632/aging.102787
   Chen K, 2017, MOL CANCER, V16, DOI 10.1186/s12943-017-0701-0
   Chen S, 2022, THERANOSTICS, V12, P2722, DOI 10.7150/thno.71360
   Chen YF, 2020, EUR J MED CHEM, V208, DOI 10.1016/j.ejmech.2020.112820
   Cheng SC, 2014, SCIENCE, V345, P1579, DOI 10.1126/science.1250684
   Chhabra G, 2021, MOLECULES, V26, DOI 10.3390/molecules26051343
   Christodoulou MI, 2017, CURR MED CHEM, V24, P14, DOI 10.2174/0929867323666160907161459
   Chung CL, 2019, GEROSCIENCE, V41, P861, DOI 10.1007/s11357-019-00113-y
   Colonna-Romano G, 2004, EXP GERONTOL, V39, P1439, DOI 10.1016/j.exger.2004.07.005
   Coyle C, 2016, ANN ONCOL, V27, P2184, DOI 10.1093/annonc/mdw410
   Cunha LL, 2020, FRONT IMMUNOL, V11, DOI 10.3389/fimmu.2020.01748
   De Haes W, 2014, P NATL ACAD SCI USA, V111, pE2501, DOI 10.1073/pnas.1321776111
   de la Lastra CA, 2005, MOL NUTR FOOD RES, V49, P405
   Delmas D, 2020, FOOD CHEM TOXICOL, V137, DOI 10.1016/j.fct.2019.111091
   Delmas D, 2011, ANN NY ACAD SCI, V1215, P48, DOI 10.1111/j.1749-6632.2010.05871.x
   DeVeale B, 2004, AGING CELL, V3, P195, DOI 10.1111/j.1474-9728.2004.00106.x
   Di Fusco D, 2018, CLIN SCI, V132, P1155, DOI 10.1042/CS20180167
   Dumas SN, 2020, J GERONTOL A-BIOL, V75, P14, DOI 10.1093/gerona/glz056
   DUMONT FJ, 1990, J IMMUNOL, V144, P251
   Dyall Julie, 2017, Drugs, V77, P1935, DOI 10.1007/s40265-017-0830-1
   Dybkowska Ewa, 2018, Rocz Panstw Zakl Hig, V69, P5
   Eikawa S, 2015, P NATL ACAD SCI USA, V112, P1809, DOI 10.1073/pnas.1417636112
   Fahy GM, 2019, AGING CELL, V18, DOI 10.1111/acel.13028
   Falchetti R, 2001, LIFE SCI, V70, P81, DOI 10.1016/S0024-3205(01)01367-4
   Foretz M, 2014, CELL METAB, V20, P953, DOI 10.1016/j.cmet.2014.09.018
   Formentini L, 2012, MOL CELL, V45, P731, DOI 10.1016/j.molcel.2012.01.008
   Franceschi C, 2017, TRENDS ENDOCRIN MET, V28, P199, DOI 10.1016/j.tem.2016.09.005
   Fulop T, 2004, AGING CELL, V3, P217, DOI 10.1111/j.1474-9728.2004.00110.x
   Fulop T, 2017, CLIN EXP IMMUNOL, V187, P35, DOI 10.1111/cei.12836
   Fulop T, 2018, FRONT IMMUNOL, V8, DOI 10.3389/fimmu.2017.01960
   Galiniak S, 2019, ACTA BIOCHIM POL, V66, P13, DOI 10.18388/abp.2018_2749
   Gambini J, 2015, OXID MED CELL LONGEV, V2015, DOI 10.1155/2015/837042
   Gao XH, 2001, BIOCHEM PHARMACOL, V62, P1299, DOI 10.1016/S0006-2952(01)00775-4
   Garsin DA, 2003, SCIENCE, V300, P1921, DOI 10.1126/science.1080147
   Glossmann HH, 2019, GERONTOLOGY, V65, P581, DOI 10.1159/000502257
   Goldberg EL, 2020, INTERD T GERONT GERI, V43, P1, DOI 10.1159/000504480
   Gomez CR, 2008, EXP GERONTOL, V43, P718, DOI 10.1016/j.exger.2008.05.016
   Gui DY, 2016, CELL METAB, V24, P716, DOI 10.1016/j.cmet.2016.09.006
   Haring A, 2017, SCAND J UROL, V51, P5, DOI 10.1080/21681805.2016.1271353
   Hasler P, 2005, CELL IMMUNOL, V233, P102, DOI 10.1016/j.cellimm.2005.04.012
   He S, 2013, CURR MED CHEM, V20, P1005
   He X, 2012, ANN ONCOL, V23, P1771, DOI 10.1093/annonc/mdr534
   Hirsch HA, 2013, P NATL ACAD SCI USA, V110, P972, DOI 10.1073/pnas.1221055110
   Howell JJ, 2017, CELL METAB, V25, P463, DOI 10.1016/j.cmet.2016.12.009
   Howitz KT, 2003, NATURE, V425, P191, DOI 10.1038/nature01960
   Huang H, 2005, FRONT BIOSCI-LANDMRK, V10, P192, DOI 10.2741/1521
   Ibrahim F, 2010, FEMS IMMUNOL MED MIC, V59, P53, DOI 10.1111/j.1574-695X.2010.00658.x
   Irazoqui JE, 2010, NAT REV IMMUNOL, V10, P47, DOI 10.1038/nri2689
   Ji LL, 2020, SEMIN ARTHRITIS RHEU, V50, P1073, DOI 10.1016/j.semarthrit.2020.07.006
   Jiang ZD, 2017, ANN NY ACAD SCI, V1403, P59, DOI 10.1111/nyas.13466
   Jing Y, 2009, HUM IMMUNOL, V70, P777, DOI 10.1016/j.humimm.2009.07.005
   Johnson SC, 2013, NATURE, V493, P338, DOI 10.1038/nature11861
   Kalender A, 2010, CELL METAB, V11, P390, DOI 10.1016/j.cmet.2010.03.014
   Kang SA, 2019, CELL CHEM BIOL, V26, P1203, DOI 10.1016/j.chembiol.2019.05.009
   Kawli T, 2010, P NATL ACAD SCI USA, V107, P13788, DOI 10.1073/pnas.0914715107
   Kennedy RB, 2016, FRONT IMMUNOL, V7, DOI 10.3389/fimmu.2016.00450
   Kim C, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21186497
   Kim D, 2008, DIS MODEL MECH, V1, P205, DOI 10.1242/dmm.000265
   Kim DH, 2002, SCIENCE, V297, P623, DOI 10.1126/science.1073759
   Kim SH, 2017, J INVEST DERMATOL, V137, P1740, DOI 10.1016/j.jid.2017.03.033
   Ko JH, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18122589
   Komaroff AL, 2017, JAMA-J AM MED ASSOC, V317, P355, DOI 10.1001/jama.2016.20099
   Kurz CL, 2003, NAT REV GENET, V4, P380, DOI 10.1038/nrg1067
   Larbi A, 2018, IMMUNITY AND INFLAMMATION IN HEALTH AND DISEASE: EMERGING ROLES OF NUTRACEUTICALS AND FUNCTIONAL FOODS IN IMMUNE SUPPORT, P319, DOI 10.1016/B978-0-12-805417-8.00026-3
   Larbi A, 2014, CYTOM PART A, V85A, P25, DOI 10.1002/cyto.a.22351
   Lee JK, 2017, MOLECULES, V22, DOI 10.3390/molecules22081287
   Lega IC, 2017, CURR ONCOL, V24, pE85, DOI 10.3747/co.24.3380
   Li HM, 2020, EXP HEMATOL, V89, P87, DOI 10.1016/j.exphem.2020.08.001
   Li XG, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-06207-x
   Li YR, 2018, BIOFACTORS, V44, P69, DOI 10.1002/biof.1400
   Ma T, 2022, NATURE, V603, P159, DOI 10.1038/s41586-022-04431-8
   MacDonald A, 2000, CLIN THER, V22, pB101, DOI 10.1016/S0149-2918(00)89027-X
   Madiraju AK, 2014, NATURE, V510, P542, DOI 10.1038/nature13270
   Maijo M, 2014, MECH AGEING DEV, V136, P116, DOI 10.1016/j.mad.2013.12.003
   Malik F, 2018, DIABETES-METAB RES, V34, DOI 10.1002/dmrr.2975
   Mallik R, 2018, DIABETES RES CLIN PR, V143, P409, DOI 10.1016/j.diabres.2018.05.023
   Mannick JB, 2014, SCI TRANSL MED, V6, DOI 10.1126/scitranslmed.3009892
   Martin DE, 2005, CURR OPIN CELL BIOL, V17, P158, DOI 10.1016/j.ceb.2005.02.008
   Martin-Montalvo A, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms3192
   McCreight LJ, 2016, DIABETOLOGIA, V59, P426, DOI 10.1007/s00125-015-3844-9
   McElhaney JE, 2015, BMJ OPEN DIAB RES CA, V3, DOI 10.1136/bmjdrc-2015-000140
   Moiseeva O, 2013, AGING CELL, V12, P489, DOI 10.1111/acel.12075
   Morgillo F, 2017, ESMO OPEN, V2, DOI 10.1136/esmoopen-2016-000132
   Mukherjee S, 2009, J TRANSPLANT, V2009, DOI 10.1155/2009/701464
   Negrotto L, 2016, JAMA NEUROL, V73, P520, DOI 10.1001/jamaneurol.2015.4807
   Ni J, 2017, SCI TRANSL MED, V9, DOI 10.1126/scitranslmed.aah6888
   Nicholas HR, 2004, CURR BIOL, V14, P1256, DOI 10.1016/j.cub.2004.07.022
   O'Neill LAJ, 2013, NATURE, V493, P346, DOI 10.1038/nature11862
   Ogrunc M, 2011, EUR J CANCER, V47, P1616, DOI 10.1016/j.ejca.2011.04.003
   Oh SJ, 2019, IMMUNE NETW, V19, DOI 10.4110/in.2019.19.e37
   Ohtani N, 2022, INFLAMM REGEN, V42, DOI 10.1186/s41232-022-00197-8
   Olsson J, 2000, MECH AGEING DEV, V121, P187
   Ongradi Joseph, 2010, Immun Ageing, V7, P7, DOI 10.1186/1742-4933-7-7
   Onken B, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0008758
   Pallauf K, 2016, CURR MED CHEM, V23, P4639, DOI 10.2174/0929867323666161024151233
   Pannu N, 2019, BIOMED PHARMACOTHER, V109, P2237, DOI 10.1016/j.biopha.2018.11.075
   Park JW, 2017, WORLD J GASTROENTERO, V23, P5196, DOI 10.3748/wjg.v23.i28.5196
   Pawelec G, 2012, IMMUN AGEING, V9, DOI 10.1186/1742-4933-9-15
   Pearce EL, 2009, NATURE, V460, P103, DOI 10.1038/nature08097
   Peng LY, 2020, THER ADV MUSCULOSKEL, V12, DOI 10.1177/1759720X20953336
   Pereira Felipe V, 2018, Oncotarget, V9, P25808, DOI 10.18632/oncotarget.25380
   Perez-Cabezas B, 2007, EXP GERONTOL, V42, P1033, DOI 10.1016/j.exger.2007.05.010
   Plowden J, 2004, AGING CELL, V3, P161, DOI 10.1111/j.1474-9728.2004.00102.x
   Pollak M, 2017, DIABETOLOGIA, V60, P1662, DOI 10.1007/s00125-017-4352-x
   Pourhanifeh MH, 2019, CURR PHARM DESIGN, V25, P2178, DOI 10.2174/1381612825666190717110932
   Powell JR, 2009, P NATL ACAD SCI USA, V106, P2782, DOI 10.1073/pnas.0813048106
   Pryor R, 2015, BIOCHEM J, V471, P307, DOI 10.1042/BJ20150497
   Ren M, 2009, IMMUNITY, V30, P521, DOI 10.1016/j.immuni.2009.03.007
   Rena G, 2017, DIABETOLOGIA, V60, P1577, DOI 10.1007/s00125-017-4342-z
   Rodriguez J, 2018, CURR OPIN CLIN NUTR, V21, P294, DOI 10.1097/MCO.0000000000000468
   Rubin BK, 2004, CHEST, V125, p70S, DOI 10.1378/chest.125.2_suppl.70S
   Saiko P, 2008, MUTAT RES-REV MUTAT, V658, P68, DOI 10.1016/j.mrrev.2007.08.004
   Saiman L, 2003, JAMA-J AM MED ASSOC, V290, P1749, DOI 10.1001/jama.290.13.1749
   Salehi B, 2018, BIOMEDICINES, V6, DOI 10.3390/biomedicines6030091
   Salminen A, 2020, AGEING RES REV, V57, DOI 10.1016/j.arr.2019.100998
   Salminen A, 2019, J MOL MED, V97, P1049, DOI 10.1007/s00109-019-01795-9
   Salminen A, 2011, J MOL MED, V89, P667, DOI 10.1007/s00109-011-0748-0
   Santos S, 2016, INT J CHRONIC OBSTR, V11, P515, DOI 10.2147/COPD.S98333
   Sargiacomo C, 2020, AGING-US, V12, P6511, DOI 10.18632/aging.103001
   Sayed Rana, 2015, Asian Pac J Cancer Prev, V16, P6621
   Scarpello JHB, 2003, DIABETES METAB, V29, pS36
   Scharping NE, 2017, CANCER IMMUNOL RES, V5, P9, DOI 10.1158/2326-6066.CIR-16-0103
   Schindowski K, 2002, MECH AGEING DEV, V123, P375, DOI 10.1016/S0047-6374(01)00396-7
   Schreiber KH, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-11174-0
   Schuiveling M, 2018, CURR DRUG TARGETS, V19, P945, DOI 10.2174/1389450118666170613081730
   SEHGAL SN, 1975, J ANTIBIOT, V28, P727, DOI 10.7164/antibiotics.28.727
   Shaw AC, 2010, CURR OPIN IMMUNOL, V22, P507, DOI 10.1016/j.coi.2010.05.003
   Shaw RJ, 2005, SCIENCE, V310, P1642, DOI 10.1126/science.1120781
   Solana R, 2014, CURR OPIN IMMUNOL, V29, P56, DOI 10.1016/j.coi.2014.04.002
   Son HJ, 2014, MEDIAT INFLAMM, V2014, DOI 10.1155/2014/973986
   Sorrenti V, 2020, MAR DRUGS, V18, DOI 10.3390/md18070351
   Sorrenti V, 2020, NUTRIENTS, V12, DOI 10.3390/nu12071908
   Sorrenti V, 2020, NUTRIENTS, V12, DOI 10.3390/nu12051265
   Sorrenti V, 2018, FRONT PHARMACOL, V9, DOI 10.3389/fphar.2018.00183
   Sorrenti V, 2016, IMMUNE NETW, V16, P344, DOI 10.4110/in.2016.16.6.344
   Springer M, 2019, NUTRIENTS, V11, DOI 10.3390/nu11010143
   Steinmann G G, 1986, Curr Top Pathol, V75, P43
   Strindhall J, 2007, EXP GERONTOL, V42, P753, DOI 10.1016/j.exger.2007.05.001
   Tarazona R, 2000, MECH AGEING DEV, V121, P77
   Tauber S C, 2008, Curr Mol Pharmacol, V1, P68
   Truong VL, 2018, BIOFACTORS, V44, P36, DOI 10.1002/biof.1399
   Tseng CH, 2016, AGING-US, V8, P1636, DOI 10.18632/aging.101019
   Tseng CW, 2014, CURR OPIN IMMUNOL, V29, P43, DOI 10.1016/j.coi.2014.03.009
   Valenzano DR, 2006, CURR BIOL, V16, P296, DOI 10.1016/j.cub.2005.12.038
   van Beek AA, 2019, TRENDS IMMUNOL, V40, P113, DOI 10.1016/j.it.2018.12.007
   Van Skike CE, 2020, AGING CELL, V19, DOI 10.1111/acel.13057
   Varoni EM, 2016, FRONT NUTR, V3, DOI 10.3389/fnut.2016.00008
   Vellas C, 2020, J NUTR HEALTH AGING, V24, P685, DOI 10.1007/s12603-020-1416-2
   Viswanathan M, 2005, DEV CELL, V9, P605, DOI 10.1016/j.devcel.2005.09.017
   Walle T, 2004, DRUG METAB DISPOS, V32, P1377, DOI 10.1124/dmd.104.000885
   Walle T, 2011, ANN NY ACAD SCI, V1215, P9, DOI 10.1111/j.1749-6632.2010.05842.x
   Walters HE, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19082325
   Wan GX, 2016, ONCOTARGET, V7, P35437, DOI 10.18632/oncotarget.8881
   Wang CH, 2014, CRIT CARE MED, V42, P313, DOI 10.1097/CCM.0b013e3182a2727d
   Weinert BT, 2003, J APPL PHYSIOL, V95, P1706, DOI 10.1152/japplphysiol.00288.2003
   Weng NP, 2006, IMMUNITY, V24, P495, DOI 10.1016/j.immuni.2006.05.001
   Wicinski M, 2018, NUTRIENTS, V10, DOI 10.3390/nu10111813
   Wicinski M, 2017, EXP THER MED, V13, P2071, DOI 10.3892/etm.2017.4180
   WICKER LS, 1990, EUR J IMMUNOL, V20, P2277, DOI 10.1002/eji.1830201017
   Wikby A, 2002, EXP GERONTOL, V37, P445, DOI 10.1016/S0531-5565(01)00212-1
   Wikby A, 1998, MECH AGEING DEV, V102, P187, DOI 10.1016/S0047-6374(97)00151-6
   Wu CH, 2018, CELL PHYSIOL BIOCHEM, V47, P1711, DOI 10.1159/000491003
   Wu LF, 2016, CELL, V167, P1705, DOI 10.1016/j.cell.2016.11.055
   Wullschleger S, 2006, CELL, V124, P471, DOI 10.1016/j.cell.2006.01.016
   Xiao Y, 2020, VIRULENCE, V11, P39, DOI 10.1080/21505594.2019.1706305
   Xiao Y, 2017, INNATE IMMUN-LONDON, V23, P656, DOI 10.1177/1753425917732822
   Yin YM, 2015, SCI TRANSL MED, V7, DOI 10.1126/scitranslmed.aaa0835
   Zhavoronkov A, 2020, SCIENCE, V368, P595, DOI 10.1126/science.aba0833
   Zhavoronkov A, 2020, AGING-US, V12, P6492, DOI 10.18632/aging.102988
   Zhou GC, 2001, J CLIN INVEST, V108, P1167, DOI 10.1172/JCI200113505
   Zhou YD, 2020, CELL DISCOV, V6, DOI 10.1038/s41421-020-0153-3
   Zmora N, 2017, CELL METAB, V25, P506, DOI 10.1016/j.cmet.2017.02.006
NR 202
TC 8
Z9 8
U1 5
U2 15
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1424-8247
J9 PHARMACEUTICALS-BASE
JI Pharmaceuticals
PD AUG
PY 2022
VL 15
IS 8
AR 912
DI 10.3390/ph15080912
PG 20
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 4B3HW
UT WOS:000845674100001
PM 35893737
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Cao, G
   Gong, T
   Du, Y
   Wang, YC
   Ge, TT
   Liu, JY
AF Cao, Gui
   Gong, Ting
   Du, Yue
   Wang, Yicun
   Ge, Tongtong
   Liu, Jingyu
TI Mechanism of metformin regulation in central nervous system: Progression
   and future perspectives
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Neuroprotection; BDNF; Neuroinflammation; AMPK activation; Neurogenesis
ID NEURAL STEM-CELLS; ADULT HIPPOCAMPAL NEUROGENESIS; ACTIVATED
   PROTEIN-KINASE; TRAUMATIC BRAIN-INJURY; HIGH-FAT-DIET; MOUSE MODEL; GUT
   MICROBIOTA; NEURONAL DIFFERENTIATION; SIGNALING PATHWAYS; SPATIAL MEMORY
AB Metformin as a first-line drug for type 2 diabetes mellitus(T2DM) treatment is widely studied. Metformin can reduce liver glucose output and improve insulin resistance. Recent evidence from in vivo and in vitro has confirmed that metformin can transport across the blood-brain barrier(BBB) and activate specific neurons and neuroglia to exert neurological actions, however, the specific effect of metformin regulation on CNS is still obscure. In this review, we summarized current evidence from preclinical evidence focusing on the regulatory role of metformin in CNS and found that metformin can exert potential neuroprotective, neurotrophic, and neurogenesis-stimulated actions; besides, metformin also exerts antiinflammatory effect by inhibiting microglial activates and regulating microglial polarization. These findings indicate there might be extensive pharmaco-logical efficacy and therapeutic insights of metformin in neurological diseases' clinical application.
C1 [Cao, Gui; Du, Yue; Liu, Jingyu] Chengdu Seventh Peoples Hosp, Dept Endocrinol, Chengdu, Peoples R China.
   [Gong, Ting] Chengdu Seventh Peoples Hosp, Dept Otolaryngol, Chengdu, Peoples R China.
   [Wang, Yicun; Ge, Tongtong] Jilin Univ, Hosp 2, Jilin Prov Key Lab Mol & Chem Genet, Changchun, Peoples R China.
C3 Jilin University
RP Liu, JY (通讯作者)，Chengdu Seventh Peoples Hosp, Dept Endocrinol, Chengdu, Peoples R China.; Ge, TT (通讯作者)，Jilin Univ, Hosp 2, Jilin Prov Key Lab Mol & Chem Genet, Changchun, Peoples R China.
EM gett@jlu.edu.cn; liujy92@163.com
FU Natural Science of Science and Technology Department of Jilin Province; 
   [20200201505JC]
FX This work is supported by Natural Science of Science and Technology
   Department of Jilin Province (20200201505JC) .
CR Abdi M, 2021, NEUROTOX RES, V39, P1732, DOI 10.1007/s12640-021-00417-y
   Ahmad W, 2017, MOL NEUROBIOL, V54, P5427, DOI 10.1007/s12035-016-0085-y
   Ahmed S, 2017, J MOL NEUROSCI, V62, P88, DOI 10.1007/s12031-017-0915-z
   Ahn MJ, 2017, BIOTECHNOL APPL BIOC, V64, P836, DOI 10.1002/bab.1584
   Akter K, 2011, BRIT J CLIN PHARMACO, V71, P365, DOI 10.1111/j.1365-2125.2010.03830.x
   Allard JS, 2016, BEHAV BRAIN RES, V301, P1, DOI 10.1016/j.bbr.2015.12.012
   Altschul DM, 2018, DIABETOLOGIA, V61, P1946, DOI 10.1007/s00125-018-4645-8
   Anacker Christoph, 2014, Curr Top Behav Neurosci, V18, P25, DOI 10.1007/7854_2014_275
   Arnoux I, 2018, ELIFE, V7, DOI 10.7554/eLife.38744
   Asgharzadeh F, 2021, INT IMMUNOPHARMACOL, V99, DOI 10.1016/j.intimp.2021.107937
   Ashabi G, 2014, METAB BRAIN DIS, V29, P47, DOI 10.1007/s11011-013-9475-2
   Aubert G, 2011, METABOLISM, V60, P327, DOI 10.1016/j.metabol.2010.02.007
   Barini E, 2016, MOL NEURODEGENER, V11, DOI 10.1186/s13024-016-0082-7
   Bayliss JA, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0159381
   Benjanuwattra J, 2020, BBA-MOL BASIS DIS, V1866, DOI 10.1016/j.bbadis.2020.165893
   Bhusal A, 2022, CELL MOL LIFE SCI, V79, DOI 10.1007/s00018-021-04019-x
   Binlateh T, 2019, EVID-BASED COMPL ALT, V2019, DOI 10.1155/2019/1765182
   Bojja SL, 2021, INFLAMMOPHARMACOLOGY, V29, P137, DOI 10.1007/s10787-020-00782-8
   Bourget C, 2022, J NEUROINFLAMM, V19, DOI 10.1186/s12974-022-02487-x
   Bramham CR, 2005, PROG NEUROBIOL, V76, P99, DOI 10.1016/j.pneurobio.2005.06.003
   Braun SMG, 2014, DEVELOPMENT, V141, P1983, DOI 10.1242/dev.104596
   Buist M, 2021, BIOMOLECULES, V11, DOI 10.3390/biom11081253
   Cameron AR, 2016, CIRC RES, V119, P652, DOI 10.1161/CIRCRESAHA.116.308445
   Cao XJ, 2021, BRAIN RES, V1772, DOI 10.1016/j.brainres.2021.147663
   Chanthammachat P, 2019, EXCLI J, V18, P812, DOI 10.17179/excli2019-1703
   Chau-Van C, 2007, ENDOCRINOLOGY, V148, P507, DOI 10.1210/en.2006-1237
   Chen B, 2016, BIOMED RES INT, V2016, DOI 10.1155/2016/1421430
   Chen J, 2022, MEDIAT INFLAMM, V2022, DOI 10.1155/2022/9821506
   Chen J, 2018, BOSNIAN J BASIC MED, V18, P49, DOI 10.17305/bjbms.2017.2044
   Chen LQ, 2021, ANN TRANSL MED, V9, DOI 10.21037/atm-21-4764
   Chen WB, 2020, BRAIN SCI, V10, DOI 10.3390/brainsci10100706
   Chen YM, 2009, P NATL ACAD SCI USA, V106, P3907, DOI 10.1073/pnas.0807991106
   Chiang MC, 2016, EXP CELL RES, V347, P322, DOI 10.1016/j.yexcr.2016.08.013
   Chung MM, 2017, EXP CELL RES, V352, P75, DOI 10.1016/j.yexcr.2017.01.017
   Costa D, 2014, CANCER CELL INT, V14, DOI 10.1186/1475-2867-14-59
   Demare S, 2021, EXPERT REV NEUROTHER, V21, P45, DOI 10.1080/14737175.2021.1847645
   Deng J, 2019, CANCER SCI, V110, P23, DOI 10.1111/cas.13849
   Diaz-Perdigones CM, 2022, BIOMED PHARMACOTHER, V145, DOI 10.1016/j.biopha.2021.112448
   DiBona VL, 2021, NEUROSCI RES, V172, P99, DOI 10.1016/j.neures.2021.05.007
   Ding Y, 2021, THERANOSTICS, V11, P9376, DOI 10.7150/thno.64706
   DiTacchio KA, 2015, J ALZHEIMERS DIS, V44, P43, DOI 10.3233/JAD-141332
   Dodiya HB, 2021, J EXP MED, V219, DOI 10.1084/jem.20200895
   El-Ghaiesh SH, 2020, FRONT MOL NEUROSCI, V13, DOI 10.3389/fnmol.2020.00084
   Fan J, 2019, BRIT J PHARMACOL, V176, P297, DOI 10.1111/bph.14519
   Fang WT, 2020, J AFFECT DISORDERS, V260, P302, DOI 10.1016/j.jad.2019.09.013
   Farr SA, 2019, J ALZHEIMERS DIS, V68, P1699, DOI 10.3233/JAD-181240
   Fatt M, 2015, STEM CELL REP, V5, P988, DOI 10.1016/j.stemcr.2015.10.014
   Gantois I, 2017, NAT MED, V23, P674, DOI 10.1038/nm.4335
   Garber AJ, 1997, AM J MED, V103, P491, DOI 10.1016/S0002-9343(97)00254-4
   Gary DS, 2002, NEUROMOL MED, V2, P261, DOI 10.1385/NMM:2:3:261
   Ge JY, 2020, DRUG DES DEV THER, V14, P1561, DOI 10.2147/DDDT.S229520
   Ge TT, 2021, PHARMACOL RES, V173, DOI 10.1016/j.phrs.2021.105909
   Ge XH, 2017, PHYSIOL BEHAV, V170, P115, DOI 10.1016/j.physbeh.2016.12.021
   Ghadernezhad N, 2016, PHARM BIOL, V54, P2211, DOI 10.3109/13880209.2016.1150306
   Glutz A, 2015, AUDIOL NEURO-OTOL, V20, P360, DOI 10.1159/000438918
   Gomez-Ambrosi J, 2014, DIABETES CARE, V37, P2813, DOI 10.2337/dc14-0937
   Grissi M, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-86905-9
   Ha J, 2015, MOL ASPECTS MED, V46, P46, DOI 10.1016/j.mam.2015.08.002
   Hassan FI, 2020, CELL J, V22, P29, DOI 10.22074/cellj.2020.7046
   Hetman M, 2006, CURR TOP MED CHEM, V6, P787, DOI 10.2174/156802606777057553
   Hill AS, 2015, NEUROPSYCHOPHARMACOL, V40, P2368, DOI 10.1038/npp.2015.85
   Hill JL, 2016, J NEUROCHEM, V139, P106, DOI 10.1111/jnc.13726
   Hong S, 2021, CNS NEUROSCI THER, V27, P1458, DOI 10.1111/cns.13726
   Hou XG, 2010, BIOCHEM BIOPH RES CO, V396, P199, DOI 10.1016/j.bbrc.2010.04.017
   Hwang IK, 2010, NEUROCHEM RES, V35, P645, DOI 10.1007/s11064-009-0115-5
   Inyang KE, 2019, PHARMACOL RES, V139, P1, DOI 10.1016/j.phrs.2018.10.027
   Jiang XY, 2005, NEUROPSYCHOPHARMACOL, V30, P1353, DOI 10.1038/sj.npp.1300703
   Jin L, 2022, FRONT PHARMACOL, V13, DOI 10.3389/fphar.2022.796616
   Katila N, 2020, BIOCHEM PHARMACOL, V180, DOI 10.1016/j.bcp.2020.114193
   Katila N, 2017, NEUROPHARMACOLOGY, V125, P396, DOI 10.1016/j.neuropharm.2017.08.015
   Kim HJ, 2016, PHYSIOL BEHAV, V154, P184, DOI 10.1016/j.physbeh.2015.11.028
   Kim HJ, 2013, PHYSIOL BEHAV, V110, P213, DOI 10.1016/j.physbeh.2013.01.011
   Kubra KT, 2021, INT IMMUNOPHARMACOL, V101, DOI 10.1016/j.intimp.2021.108367
   Kuhla A, 2019, J ALZHEIMERS DIS, V68, P1415, DOI 10.3233/JAD-181017
   Kusne Y, 2014, AGE, V36, P199, DOI 10.1007/s11357-013-9572-5
   Leech T, 2020, EUR J PHARMACOL, V885, DOI 10.1016/j.ejphar.2020.173418
   Li JJ, 2012, PHARMACOL BIOCHEM BE, V101, P564, DOI 10.1016/j.pbb.2012.03.002
   Li J, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0127967
   Li LX, 2019, BASIC CLIN PHARMACOL, V125, P439, DOI 10.1111/bcpt.13279
   Lilly M, 2009, CAN FAM PHYSICIAN, V55, P363
   Lin CH, 2021, CURR NEUROVASC RES, V18, P351, DOI 10.2174/1567202618666210923150251
   Lin YB, 2022, BEHAV BRAIN RES, V423, DOI 10.1016/j.bbr.2022.113772
   Lin YF, 2018, FRONT AGING NEUROSCI, V10, DOI 10.3389/fnagi.2018.00227
   Liu D., 2022, MOL PSYCHIATR
   Liu WN, 2019, J AFFECT DISORDERS, V246, P486, DOI 10.1016/j.jad.2018.12.112
   Liu YQ, 2014, J NEUROINFLAMM, V11, DOI 10.1186/s12974-014-0177-4
   Liu ZY, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.640347
   Lu M, 2016, INT J NEUROPSYCHOPH, V19, DOI 10.1093/ijnp/pyw047
   Luo QQ, 2012, BMC CANCER, V12, DOI 10.1186/1471-2407-12-517
   Lyu YF, 2022, PHYTOMEDICINE, V101, DOI 10.1016/j.phymed.2022.154099
   Ma JX, 2015, EUR J PHARMACOL, V764, P599, DOI 10.1016/j.ejphar.2015.06.010
   Ma XY, 2021, BRAIN BEHAV IMMUN, V95, P68, DOI 10.1016/j.bbi.2021.02.011
   Magzoub R, 2022, EUR J OBSTET GYN R B, V271, P38, DOI 10.1016/j.ejogrb.2022.01.025
   Mandwie M, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms222413660
   Maniar K, 2017, PHARMACOL RES, V117, P103, DOI 10.1016/j.phrs.2016.12.003
   Markowicz-Piasecka M, 2017, PHARM RES-DORDR, V34, P2614, DOI 10.1007/s11095-017-2199-y
   Martinowich K, 2008, NEUROPSYCHOPHARMACOL, V33, P73, DOI 10.1038/sj.npp.1301571
   McNeilly AD, 2012, DIABETOLOGIA, V55, P3061, DOI 10.1007/s00125-012-2686-y
   Mendonca IP, 2022, INT IMMUNOPHARMACOL, V102, DOI 10.1016/j.intimp.2021.108415
   Miller RA, 2010, J CLIN INVEST, V120, P2267, DOI 10.1172/JCI43661
   Mohamed MA, 2020, EPILEPSY BEHAV, V104, DOI 10.1016/j.yebeh.2019.106893
   Monyak RE, 2017, MOL PSYCHIATR, V22, P1140, DOI 10.1038/mp.2016.51
   Mudgal J, 2019, INFLAMMOPHARMACOLOGY, V27, P941, DOI 10.1007/s10787-019-00638-w
   Munoz-Arenas G, 2020, SYNAPSE, V74, DOI 10.1002/syn.22153
   Nassif RM, 2022, BIOMEDICINES, V10, DOI 10.3390/biomedicines10020319
   Ning PP, 2022, NEUROPHARMACOLOGY, V207, DOI 10.1016/j.neuropharm.2022.108966
   Noch E, 2009, CANCER BIOL THER, V8, P1791, DOI 10.4161/cbt.8.19.9762
   Oliveira WH, 2016, BRAIN RES, V1644, P149, DOI 10.1016/j.brainres.2016.05.013
   Ou ZR, 2018, BRAIN BEHAV IMMUN, V69, P351, DOI 10.1016/j.bbi.2017.12.009
   Ould-Brahim F, 2018, STEM CELLS DEV, V27, P1085, DOI 10.1089/scd.2018.0055
   Ouyang J, 2020, AIDS RES THER, V17, DOI 10.1186/s12981-020-00267-2
   Pan YB, 2016, J NEUROINFLAMM, V13, DOI 10.1186/s12974-016-0754-9
   Park JW, 2022, EXP GERONTOL, V160, DOI 10.1016/j.exger.2022.111706
   Patil SP, 2014, NEUROSCIENCE, V277, P747, DOI 10.1016/j.neuroscience.2014.07.046
   Peng L., 2022, INT IMMUNOPHARMACOL, V109
   Peng LY, 2021, FRONT AGING NEUROSCI, V13, DOI 10.3389/fnagi.2021.686506
   Pescador N, 2021, REDOX BIOL, V48, DOI 10.1016/j.redox.2021.102171
   Pilipenko V, 2020, EUR J PHARMACOL, V881, DOI 10.1016/j.ejphar.2020.173290
   Portela LV, 2015, NEUROCHEM RES, V40, P514, DOI 10.1007/s11064-014-1496-7
   Prasad S, 2017, REDOX BIOL, V12, P58, DOI 10.1016/j.redox.2017.02.007
   Rad SK, 2018, DRUG DES DEV THER, V12, P3999, DOI 10.2147/DDDT.S173970
   Rahimi S, 2020, METAB BRAIN DIS, V35, P1135, DOI 10.1007/s11011-020-00594-3
   Roland AV, 2011, ENDOCRINOLOGY, V152, P618, DOI 10.1210/en.2010-0823
   Ronnett GV, 2009, J NEUROCHEM, V109, P17, DOI 10.1111/j.1471-4159.2009.05916.x
   Rouquet T, 2014, OBESITY, V22, P2552, DOI 10.1002/oby.20902
   Ruan CL, 2021, BRAIN BEHAV, V11, DOI 10.1002/brb3.2335
   Ruddy RM, 2019, SCI ADV, V5, DOI 10.1126/sciadv.aax1912
   Ruegsegger GN, 2019, JCI INSIGHT, V4, DOI 10.1172/jci.insight.130681
   Ryu YK, 2020, NEUROPHARMACOLOGY, V175, DOI 10.1016/j.neuropharm.2020.108173
   Ryu YK, 2018, MOL NEUROBIOL, V55, P5715, DOI 10.1007/s12035-017-0752-7
   Salomaki-Myftari H, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0163805
   Sanchis A, 2019, EXP MOL MED, V51, DOI 10.1038/s12276-019-0264-9
   Sao R, 2018, ARCH MED SCI, V14, P1233, DOI 10.5114/aoms.2017.68821
   Sato A, 2012, STEM CELL TRANSL MED, V1, P811, DOI 10.5966/sctm.2012-0058
   Shiers S, 2018, J NEUROSCI, V38, P7337, DOI 10.1523/JNEUROSCI.0713-18.2018
   Smieszek A, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18040872
   Son SM, 2016, J ALZHEIMERS DIS, V51, P1197, DOI 10.3233/JAD-151200
   Song WY, 2021, NEURAL REGEN RES, V16, DOI 10.4103/1673-5374.310695
   Sritawan N, 2020, BIOMED PHARMACOTHER, V131, DOI 10.1016/j.biopha.2020.110651
   Stroup TS, 2018, WORLD PSYCHIATRY, V17, P341, DOI 10.1002/wps.20567
   Svirskiene N, 2021, BRAIN RES, V1750, DOI 10.1016/j.brainres.2020.147151
   Syal C, 2020, THERANOSTICS, V10, P6337, DOI 10.7150/thno.44962
   Tang BL, 2020, REV NEUROSCIENCE, V31, P297, DOI 10.1515/revneuro-2019-0072
   Tanokashira D, 2018, FEBS OPEN BIO, V8, P1104, DOI 10.1002/2211-5463.12436
   Tao L, 2018, BRAIN RES BULL, V140, P154, DOI 10.1016/j.brainresbull.2018.04.008
   Tayara K, 2018, FRONT CELL NEUROSCI, V12, DOI 10.3389/fncel.2018.00440
   Tse JKY, 2017, ACS CHEM NEUROSCI, V8, P1438, DOI 10.1021/acschemneuro.7b00176
   Vazifehkhah S, 2020, LIFE SCI, V257, DOI 10.1016/j.lfs.2020.118066
   Venu VKP, 2021, MOL PHARMACOL, V100, P428, DOI 10.1124/molpharm.120.000148
   Wang J, 2012, CELL STEM CELL, V11, P23, DOI 10.1016/j.stem.2012.03.016
   Wang L, 2018, FRONT BEHAV NEUROSCI, V12, DOI 10.3389/fnbeh.2018.00290
   Wang L, 2021, EUR NEUROL, V84, P212, DOI 10.1159/000514431
   Wang QQ, 2021, ALZHEIMERS RES THER, V13, DOI 10.1186/s13195-021-00917-1
   Wang YL, 2020, FRONT CELL NEUROSCI, V14, DOI 10.3389/fncel.2020.00170
   Wang YW, 2017, DRUG DES DEV THER, V11, P2421, DOI 10.2147/DDDT.S141675
   Wang YF, 2019, EPIGENOMICS-UK, V11, P655, DOI 10.2217/epi-2018-0187
   Watanabe K, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22094439
   Wen HC, 2021, FOOD FUNCT, V12, P10994, DOI [10.1039/d1fo02122b, 10.1039/D1FO02122B]
   Wu YL, 2022, ACTA PHARMACOL SIN, V43, P747, DOI 10.1038/s41401-021-00692-7
   Xian HX, 2021, IMMUNITY, V54, P1463, DOI 10.1016/j.immuni.2021.05.004
   Xiang XW, 2022, IUBMB LIFE, V74, P259, DOI 10.1002/iub.2588
   Xu L, 2016, ADV EXP MED BIOL, V854, P425, DOI 10.1007/978-3-319-17121-0_56
   Xu XY, 2021, PROTEIN CELL, V12, P769, DOI 10.1007/s13238-021-00858-3
   Xue J, 2019, ENDOCR J, V66, P859, DOI 10.1507/endocrj.EJ18-0567
   Yan QT, 2017, MOL PHARMACOL, V92, P640, DOI 10.1124/mol.117.109512
   Yang AJT, 2019, J ALZHEIMERS DIS, V71, P945, DOI 10.3233/JAD-190123
   Yang JQ, 2022, BIOMED PHARMACOTHER, V149, DOI 10.1016/j.biopha.2022.112837
   Yang Y, 2017, BIOCHEM BIOPH RES CO, V484, P450, DOI 10.1016/j.bbrc.2017.01.157
   Yerevanian A, 2019, CURR OBES REP, V8, P156, DOI 10.1007/s13679-019-00335-3
   Yu BX, 2020, BIOCHEM BIOPH RES CO, V522, P838, DOI 10.1016/j.bbrc.2019.11.181
   Yu X., 2021, FRONT CELL NEUROSCI, V15
   Yu XJ, 2022, TOXICOL APPL PHARM, V437, DOI 10.1016/j.taap.2022.115893
   Yuan R, 2019, NEUROREPORT, V30, P232, DOI 10.1097/WNR.0000000000001190
   Yue HY, 2019, EXP THER MED, V17, P1463, DOI 10.3892/etm.2018.7098
   Zemdegs J, 2019, J NEUROSCI, V39, P5935, DOI 10.1523/JNEUROSCI.2904-18.2019
   Zhang L, 2022, STEM CELLS, V40, P59, DOI 10.1093/stmcls/sxab001
   Zhang T, 2020, NEUROSCI LETT, V739, DOI 10.1016/j.neulet.2020.135440
   Zhao HY, 2022, FRONT IMMUNOL, V13, DOI 10.3389/fimmu.2022.797312
   Zhao M, 2019, BEHAV BRAIN RES, V363, P30, DOI 10.1016/j.bbr.2019.01.048
   Zhao X., 2019, J CELL PHYSIOL
   Zhou CL, 2021, BMC NEUROSCI, V22, DOI 10.1186/s12868-021-00678-5
   Zhou CH, 2020, FRONT NEUROSCI-SWITZ, V14, DOI 10.3389/fnins.2020.00517
   Zhou WJ, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0151890
   Zou WY, 2022, BIOENGINEERED, V13, P4385, DOI 10.1080/21655979.2022.2033411
NR 184
TC 2
Z9 2
U1 6
U2 10
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD DEC
PY 2022
VL 156
AR 113686
DI 10.1016/j.biopha.2022.113686
EA OCT 2022
PG 11
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 5R6DC
UT WOS:000874597900008
PM 36244266
OA gold
DA 2023-06-08
ER

PT J
AU Koo, H
   Morrow, CD
AF Koo, Hyunmin
   Morrow, Casey D.
TI Perturbation of the human gastrointestinal tract microbial ecosystem by
   oral drugs to treat chronic disease results in a spectrum of individual
   specific patterns of extinction and persistence of dominant microbial
   strains
SO PLOS ONE
LA English
DT Article
ID GUT MICROBIOME; INTESTINAL MICROBIOTA; RHEUMATOID-ARTHRITIS; READ
   ALIGNMENT; RECOVERY
AB Background
   Oral drugs can have side effects such as diarrhea that indicate the perturbation of the gut microbial community. To further understand the dynamics of perturbation, we have assessed the strain relatedness of samples from previously published data sets from pre and post bowel evacuation, episodes of diarrhea, and administration of oral drugs to treat diabetes and rheumatoid arthritis.
   Methods
   We analyzed a total of published five data sets using our strain-tracking tool called Window-based Single Nucleotide Variant (SNV) Similarity (WSS) to identify related strains from the same individual.
   Results
   Strain-tracking analysis using the first data set from 8 individuals pre and 21-50 days post iso-osmotic bowel wash revealed almost all microbial strains were related in an individual between pre and post samples. Similarly, in a second study, strain-tracking analysis of 4 individuals pre and post sporadic diarrhea revealed the majority of strains were related over time (up to 44 weeks). In contrast, the analysis of a third data set from 22 individuals pre and post 3-day exposure of oral metformin revealed that no individuals had a related strain. In a fourth study, the data set taken at 2 and 4 months from 38 individuals on placebo or metformin revealed individual specific sharing of pre and post strains. Finally, the data set from 18 individuals with rheumatoid arthritis given disease-modifying antirheumatic drugs methotrexate or glycosides of the traditional Chinese medicinal component Tripterygium wilfordii showed individual specific sharing of pre and post strains up to 16 months.
   Conclusion
   Oral drugs used to treat chronic disease can result in individual specific microbial strain change for the majority of species. Since the gut community provides essential functions for the host, our study supports personalized monitoring to assess the status of the dominant microbial strains after initiation of oral drugs to treat chronic disease.
C1 [Koo, Hyunmin] Univ Alabama Birmingham, Dept Genet, Birmingham, AL 35294 USA.
   [Morrow, Casey D.] Univ Alabama Birmingham, Dept Cell Dev & Integrat Biol, Birmingham, AL 35294 USA.
C3 University of Alabama System; University of Alabama Birmingham;
   University of Alabama System; University of Alabama Birmingham
RP Koo, H (通讯作者)，Univ Alabama Birmingham, Dept Genet, Birmingham, AL 35294 USA.; Morrow, CD (通讯作者)，Univ Alabama Birmingham, Dept Cell Dev & Integrat Biol, Birmingham, AL 35294 USA.
EM khmkhm87@uab.edu; caseym@uab.edu
OI Koo, Hyunmin/0000-0001-6630-2165
FU UAB School of Medicine
FX We thank the UAB Information Technology Research Computing group for
   providing the high-performance computing support necessary for
   bioinformatics analyses. We thank Adrienne Ellis for preparation of the
   manuscript. We also thank UAB School of Medicine for supporting this
   study.
CR Backhed F, 2012, CELL HOST MICROBE, V12, P611, DOI 10.1016/j.chom.2012.10.012
   Baumler AJ, 2016, NATURE, V535, P85, DOI 10.1038/nature18849
   Becattini S, 2016, TRENDS MOL MED, V22, P458, DOI 10.1016/j.molmed.2016.04.003
   BODET CA, 1985, ANTIMICROB AGENTS CH, V28, P437, DOI 10.1128/AAC.28.3.437
   Bolger AM, 2014, BIOINFORMATICS, V30, P2114, DOI 10.1093/bioinformatics/btu170
   Bonnet F, 2017, DIABETES OBES METAB, V19, P473, DOI 10.1111/dom.12854
   Brunkwall L, 2017, DIABETOLOGIA, V60, P943, DOI 10.1007/s00125-017-4278-3
   Buffie CG, 2013, NAT REV IMMUNOL, V13, P790, DOI 10.1038/nri3535
   Cho I, 2012, NAT REV GENET, V13, P260, DOI 10.1038/nrg3182
   David LA, 2015, MBIO, V6, DOI 10.1128/mBio.00381-15
   Dethlefsen L, 2011, P NATL ACAD SCI USA, V108, P4554, DOI 10.1073/pnas.1000087107
   Dethlefsen L, 2008, PLOS BIOL, V6, P2383, DOI 10.1371/journal.pbio.0060280
   Donaldson GP, 2016, NAT REV MICROBIOL, V14, P20, DOI 10.1038/nrmicro3552
   Truong DT, 2017, GENOME RES, V27, P626, DOI 10.1101/gr.216242.116
   Elbere I, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0204317
   Et S.A A. Alj, 2012, EUROPEAN J BUSINESS, V4, P156
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Franzosa EA, 2015, P NATL ACAD SCI USA, V112, pE2930, DOI 10.1073/pnas.1423854112
   Fukuyama J, 2017, PLOS COMPUT BIOL, V13, DOI 10.1371/journal.pcbi.1005706
   Gorkiewicz G, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0055817
   Hsiao A, 2014, NATURE, V515, P423, DOI 10.1038/nature13738
   Imhann F, 2017, GUT MICROBES, V8, P351, DOI 10.1080/19490976.2017.1284732
   Jalanka J, 2015, GUT, V64, P1562, DOI 10.1136/gutjnl-2014-307240
   Jernberg C, 2007, ISME J, V1, P56, DOI 10.1038/ismej.2007.3
   Kishikawa T, 2020, ANN RHEUM DIS, V79, P103, DOI 10.1136/annrheumdis-2019-215743
   Koo H, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0226111
   Koo H, 2019, NPJ BIOFILMS MICROBI, V5, DOI 10.1038/s41522-019-0103-8
   Kumar R., 2018, HUMAN MICROBIOME J, V10, P37, DOI [10.1016/j.humic.2018.10.002, DOI 10.1016/J.HUMIC.2018.10.002]
   Kumar R, 2017, NPJ BIOFILMS MICROBI, V3, DOI 10.1038/s41522-017-0020-7
   Kumar S, 2018, MOL BIOL EVOL, V35, P1547, DOI 10.1093/molbev/msy096
   Langmead B, 2012, NAT METHODS, V9, P357, DOI [10.1038/NMETH.1923, 10.1038/nmeth.1923]
   Li H, 2010, BIOINFORMATICS, V26, P589, DOI 10.1093/bioinformatics/btp698
   Lloyd-Price J, 2019, NATURE, V569, P655, DOI 10.1038/s41586-019-1237-9
   Lloyd-Price J, 2016, GENOME MED, V8, DOI 10.1186/s13073-016-0307-y
   Lv QW, 2015, ANN RHEUM DIS, V74, P1078, DOI 10.1136/annrheumdis-2013-204807
   Maier L, 2018, NATURE, V555, P623, DOI 10.1038/nature25979
   Maynard CL, 2012, NATURE, V489, P231, DOI 10.1038/nature11551
   O'Brien CL, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0062815
   Palleja A, 2018, NAT MICROBIOL, V3, P1255, DOI 10.1038/s41564-018-0257-9
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Raymond F, 2016, ISME J, V10, P707, DOI 10.1038/ismej.2015.148
   Schloissnig S, 2013, NATURE, V493, P45, DOI 10.1038/nature11711
   Segata N, 2018, MSYSTEMS, V3, DOI 10.1128/mSystems.00190-17
   Segata N, 2012, NAT METHODS, V9, P811, DOI [10.1038/NMETH.2066, 10.1038/nmeth.2066]
   Shaw LP, 2019, ISME J, V13, P1845, DOI 10.1038/s41396-019-0392-1
   Stecher G, 2020, MOL BIOL EVOL, V37, P1237, DOI 10.1093/molbev/msz312
   Van der Auwera Geraldine A, 2013, Curr Protoc Bioinformatics, V43, DOI [10.1002/0471250953.bi1201s43, 10.1002/0471250953.bi1110s43]
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Tamura K, 2004, P NATL ACAD SCI USA, V101, P11030, DOI 10.1073/pnas.0404206101
   Team RC, 2016, R LANG ENV STAT COMP
   The Lancet Hiv null, 2020, LANCET HIV, V7, pe75
   Truong DT, 2015, NAT METHODS, V12, P902, DOI 10.1038/nmeth.3589
   Wang QQ, 2019, BMC GENOMICS, V20, DOI 10.1186/s12864-019-5510-y
   Wu GD, 2011, SCIENCE, V334, P105, DOI 10.1126/science.1208344
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Zhang X, 2015, NAT MED, V21, P895, DOI 10.1038/nm.3914
NR 56
TC 5
Z9 5
U1 0
U2 4
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD DEC 1
PY 2020
VL 15
IS 12
AR e0242021
DI 10.1371/journal.pone.0242021
PG 16
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA PB7NK
UT WOS:000596503200023
PM 33259474
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Bravard, A
   Gerard, C
   Defois, C
   Benoit, B
   Makki, K
   Meugnier, E
   Rainteau, D
   Rieusset, J
   Godet, M
   Vidal, H
AF Bravard, Amelie
   Gerard, Celine
   Defois, Clemence
   Benoit, Berengere
   Makki, Kassem
   Meugnier, Emmanuelle
   Rainteau, Dominique
   Rieusset, Jennifer
   Godet, Murielle
   Vidal, Hubert
TI Metformin treatment for 8 days impacts multiple intestinal parameters in
   high-fat high-sucrose fed mice
SO SCIENTIFIC REPORTS
LA English
DT Article
ID ACID; ALTERS; AMPK
AB Although the mechanism of action of the antidiabetic drug metformin is still a matter of discussions, it is well accepted that the gut plays an important role. To gain more insights into the mechanisms occurring in the different regions of the intestine, adult male mice were fed a high-fat-high sucrose (HFS) diet for 8 days and treated with metformin by gavage (300 mg/day/kg body weight) during the HFS diet. Metformin counteracted HFS diet-induced overexpression of a network of genes involved in the transport of glucose and fatty acids in the different regions of the small intestine. It also induced beneficial modification of secondary bile acid profile in the caecum, with a reduction of deoxycholic acid and lithocholic acid levels and increased abundance of ursodeoxycholic acid and tauroursodeoxycholic acid, potentially leading to FRX inhibition. In parallel, metformin treatment was associated with specific changes of the microbiota composition in the lumen of the different regions of the intestine. Metformin induced a marked increase in the abundance of Akkermansia muciniphila in the lumen all along the gut and counteracted the effects of HFS diet on the abundances of some bacterial groups generally associated with metabolic disturbances (f-Lachnospiraceae, f-Petostreptococcaceae, g-Clostidium). Therefore, the present work clearly emphasises the role of all the regions of the intestinal tract in the beneficial action of the antidiabetic drug metformin in a prediabetic mouse model.
C1 [Bravard, Amelie; Gerard, Celine; Defois, Clemence; Benoit, Berengere; Makki, Kassem; Meugnier, Emmanuelle; Rieusset, Jennifer; Godet, Murielle; Vidal, Hubert] Univ Claude Bernard Lyon1, Univ Lyon, INRAE U1397, Lab CarMeN,INSERM U1060, F-69600 Oullins, France.
   [Rieusset, Jennifer] Sorbonne Univ, INSERM U938, Ctr Rech St Antoine, F-75012 Paris, France.
   [Makki, Kassem] Univ Gothenburg, Inst Med, Wallenberg Lab, Dept Mol & Clin Med, Gothenburg, Sweden.
   [Makki, Kassem] Sahlgrens Univ Hosp, Gothenburg, Sweden.
C3 INRAE; Institut National de la Sante et de la Recherche Medicale
   (Inserm); UDICE-French Research Universities; Universite Claude Bernard
   Lyon 1; Institut National de la Sante et de la Recherche Medicale
   (Inserm); UDICE-French Research Universities; Sorbonne Universite;
   University of Gothenburg; Sahlgrenska University Hospital
RP Vidal, H (通讯作者)，Univ Claude Bernard Lyon1, Univ Lyon, INRAE U1397, Lab CarMeN,INSERM U1060, F-69600 Oullins, France.
EM hubert.vidal@univ-lyon1.fr
RI Vidal, Hubert/M-6674-2017; Carmen, Team1/Y-7382-2019; makki,
   kassem/HTN-0263-2023; Carmen, Team2/Y-7383-2019; Rieusset,
   Jennifer/F-1595-2018
OI Vidal, Hubert/0000-0002-9467-0317; Carmen, Team1/0000-0003-4234-1746;
   Carmen, Team2/0000-0001-9867-5724; Godet, Murielle/0000-0001-9879-4731;
   Lab, Carmen/0000-0002-5935-3236; Rieusset, Jennifer/0000-0002-1587-2253;
   meugnier, emmanuelle/0000-0002-2291-7691
FU Fondation Francophone pour la Recherche sur le Diabete; Region
   Auvergne-Rhone-Alpes (Pack Ambition Recherche); INSERM (French
   transversal program on microbiota)
FX This work was funded by grants from the "Fondation Francophone pour la
   Recherche sur le Diabete" (FFRD 2018) (PROBIODIAB 2018), from Region
   Auvergne-Rhone-Alpes ("Pack Ambition Recherche >> Probiodiab 2017) and
   from INSERM (French transversal program on microbiota).
CR Adeshirlarijaney A, 2019, AM J PHYSIOL-ENDOC M, V317, pE1121, DOI 10.1152/ajpendo.00245.2019
   Bahne E, 2018, JCI INSIGHT, V3, DOI 10.1172/jci.insight.93936
   Bauer PV, 2018, CELL METAB, V27, P101, DOI 10.1016/j.cmet.2017.09.019
   Bolyen E, 2019, NAT BIOTECHNOL, V37, P852, DOI 10.1038/s41587-019-0209-9
   Bronden A, 2017, J CLIN ENDOCR METAB, V102, P4153, DOI 10.1210/jc.2017-01091
   Buse JB, 2016, DIABETES CARE, V39, P198, DOI 10.2337/dc15-0488
   Degirolamo C, 2016, NAT REV DRUG DISCOV, V15, P51, DOI 10.1038/nrd.2015.9
   Depommier C, 2021, CELLS-BASEL, V10, DOI 10.3390/cells10010185
   Doerner KC, 1997, APPL ENVIRON MICROB, V63, P1185, DOI 10.1128/AEM.63.3.1185-1188.1997
   Foretz M, 2019, NAT REV ENDOCRINOL, V15, P569, DOI 10.1038/s41574-019-0242-2
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Funabashi M, 2020, NATURE, V582, P566, DOI 10.1038/s41586-020-2396-4
   Gontier E, 2008, EUR J NUCL MED MOL I, V35, P95, DOI 10.1007/s00259-007-0563-6
   Harmel E, 2014, ENDOCRINOLOGY, V155, P873, DOI 10.1210/en.2013-1750
   Horakova O, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-42531-0
   Humbert L, 2012, J CHROMATOGR B, V899, P135, DOI 10.1016/j.jchromb.2012.05.015
   Hundal RS, 2000, DIABETES, V49, P2063, DOI 10.2337/diabetes.49.12.2063
   Ikeda T, 2000, BIOCHEM PHARMACOL, V59, P887, DOI 10.1016/S0006-2952(99)00396-2
   Kameyama K, 2014, MICROBES ENVIRON, V29, P427, DOI 10.1264/jsme2.ME14054
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Lepercq P, 2004, FEMS MICROBIOL LETT, V235, P65, DOI [10.1111/j.1574-6968.2004.tb09568.x, 10.1016/j.femsle.2004.04.011]
   Lien F, 2014, J CLIN INVEST, V124, P1037, DOI 10.1172/JCI68815
   Ma W, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.01336
   Napolitano A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100778
   Naville D, 2019, CHEMOSPHERE, V220, P1187, DOI 10.1016/j.chemosphere.2018.12.177
   Ouyang J, 2020, FRONT IMMUNOL, V11, DOI 10.3389/fimmu.2020.00645
   Piwowarek K, 2018, APPL MICROBIOL BIOT, V102, P515, DOI 10.1007/s00253-017-8616-7
   Sansome DJ, 2020, DIABETES OBES METAB, V22, P141, DOI 10.1111/dom.13869
   Setchell KDR, 2010, J NUTR, V140, p1363S, DOI 10.3945/jn.109.119784
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   SUM CF, 1992, DIABETIC MED, V9, P61, DOI 10.1111/j.1464-5491.1992.tb01716.x
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Vacca M, 2020, MICROORGANISMS, V8, DOI 10.3390/microorganisms8040573
   Vial G, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00294
   Wang Y, 2017, ENDOCR J, V64, P543, DOI 10.1507/endocrj.EJ16-0391
   WILCOCK C, 1994, XENOBIOTICA, V24, P49, DOI 10.3109/00498259409043220
   Wooley JC, 2010, J COMPUT SCI TECH-CH, V25, P71, DOI 10.1007/s11390-010-9306-4
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Yu JH, 2002, J BIOL CHEM, V277, P31441, DOI 10.1074/jbc.M200474200
   Zhang X, 2015, SCI REP-UK, V5, DOI 10.1038/srep14405
NR 40
TC 5
Z9 5
U1 0
U2 5
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD AUG 17
PY 2021
VL 11
IS 1
AR 16684
DI 10.1038/s41598-021-95117-0
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA UC7GU
UT WOS:000686690900049
PM 34404817
OA Green Published, Green Submitted, gold
DA 2023-06-08
ER

PT J
AU Wang, YY
   Ye, XL
   Ding, DF
   Lu, YB
AF Wang, Yayun
   Ye, Xiaolong
   Ding, Dafa
   Lu, Yibing
TI Characteristics of the intestinal flora in patients with peripheral
   neuropathy associated with type 2 diabetes
SO JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
LA English
DT Article
DE Diabetic peripheral neuropathy; type 2 diabetes; gastrointestinal
   microbiota; microbial diversity; insulin resistance; bile acids;
   richness; blood chemistry
ID GUT MICROBIOTA; INSULIN-RESISTANCE; METFORMIN
AB Objective To study the characteristics of the intestinal flora in patients with diabetic peripheral neuropathy (DPN) and analyze the association between the intestinal flora and clinical indicators. Methods We classified 80 subjects into three groups: patients with DPN (n = 45), patients type 2 diabetes without DPN (n = 21), and healthy controls (n = 14). The intestinal flora composition was compared among the three groups, and the correlation between the intestinal flora and clinical indicators was analyzed. Results At the phylum level, the richness of Firmicutes and Actinobacteria was elevated in the DN group, and that of Bacteroidetes was decreased. At the genus level, the richness ofBacteroidesandFaecalibacteriumwas significantly decreased in the DPN group, whereas that ofEscherichia-Shigella,Lachnoclostridium,Blautia,Megasphaera, andRuminococcus torquesgroup was increased. The homeostasis model assessment insulin resistance index was positively correlated withMegasphaerarichness. Glycine ursodeoxycholic acid was positively correlated withRuminococcus gnavusgroup andPhascolarctobacteriumrichness. Tauroursodeoxycholic acid was positively correlated withRuminococcus gnavusgroup andParabacteroidesrichness. Conclusion There was obvious intestinal microbiota disorder in patients with DPN, which may be related to insulin resistance. These changes may have important roles in the development of DPN.
C1 [Wang, Yayun; Ye, Xiaolong; Ding, Dafa; Lu, Yibing] Nanjing Med Univ, Affiliated Hosp 2, Dept Endocrinol, 121 Jiangjiayuan, Nanjing 210011, Peoples R China.
C3 Nanjing Medical University
RP Lu, YB (通讯作者)，Nanjing Med Univ, Affiliated Hosp 2, Dept Endocrinol, 121 Jiangjiayuan, Nanjing 210011, Peoples R China.
EM luyibing2004@126.com
CR Al-Sulaiti H, 2019, J TRANSL MED, V17, DOI 10.1186/s12967-019-2096-8
   Armour CR, 2019, MSYSTEMS, V4, DOI 10.1128/mSystems.00332-18
   Cani PD, 2019, NAT REV ENDOCRINOL, V15, P69, DOI 10.1038/s41574-018-0143-9
   Gu YY, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-01682-2
   Iqbal Z, 2018, CLIN THER, V40, P828, DOI 10.1016/j.clinthera.2018.04.001
   Ma QT, 2019, BIOMED PHARMACOTHER, V117, DOI 10.1016/j.biopha.2019.109138
   Madsbad S, 2014, LANCET DIABETES ENDO, V2, P152, DOI 10.1016/S2213-8587(13)70218-3
   Mardinoglu A, 2016, CELL METAB, V23, P10, DOI 10.1016/j.cmet.2015.12.012
   Mortreux M, 2019, MOL METAB, V29, P182, DOI 10.1016/j.molmet.2019.08.016
   Munoz-Garach A, 2016, ENDOCRINOL NUTR, V63, P560, DOI 10.1016/j.endonu.2016.07.008
   Park MY, 2016, J APPL MICROBIOL, V121, P800, DOI 10.1111/jam.13158
   Prabodha LBL, 2018, INT J ENDOCRINOL, V2018, DOI 10.1155/2018/8641942
   Qin JJ, 2010, NATURE, V464, P59, DOI 10.1038/nature08821
   Rolim LCSP, 2019, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD011265.pub2
   Sabico S, 2019, CLIN NUTR, V38, P1561, DOI 10.1016/j.clnu.2018.08.009
   Sanchis-Chorda J, 2019, EUR J NUTR, V58, P2789, DOI 10.1007/s00394-018-1828-5
   Sattar N, 2017, LANCET DIABETES ENDO, V5, P331, DOI 10.1016/S2213-8587(17)30117-1
   Udayappan SD, 2014, CLIN EXP IMMUNOL, V177, P24, DOI 10.1111/cei.12293
   Wang K, 2019, CELL REP, V26, P222, DOI 10.1016/j.celrep.2018.12.028
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Yagihashi S, 2011, J DIABETES INVEST, V2, P18, DOI 10.1111/j.2040-1124.2010.00070.x
   Yuan X, 2018, J CELL BIOCHEM, V119, P10067, DOI 10.1002/jcb.27343
   Zhao LJ, 2019, ENDOCRINE, V66, P526, DOI 10.1007/s12020-019-02103-8
   Zhou WY, 2019, NATURE, V569, P663, DOI 10.1038/s41586-019-1236-x
   ZHU CL, 2018, MEDICINE, V97, DOI DOI 10.1097/MD.0000000000012399
NR 25
TC 21
Z9 23
U1 1
U2 16
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0300-0605
EI 1473-2300
J9 J INT MED RES
JI J. Int. Med. Res.
PD SEP
PY 2020
VL 48
IS 9
AR 0300060520936806
DI 10.1177/0300060520936806
PG 15
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA NU7YY
UT WOS:000573856600001
PM 32938282
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Petakh, P
   Kamyshna, I
   Nykyforuk, A
   Yao, RA
   Imbery, JF
   Oksenych, V
   Korda, M
   Kamyshnyi, A
AF Petakh, Pavlo
   Kamyshna, Iryna
   Nykyforuk, Andriy
   Yao, Rouan
   Imbery, John F.
   Oksenych, Valentyn
   Korda, Mykhaylo
   Kamyshnyi, Aleksandr
TI Immunoregulatory Intestinal Microbiota and COVID-19 in Patients with
   Type Two Diabetes: A Double-Edged Sword
SO VIRUSES-BASEL
LA English
DT Review
DE type 2 diabetes; metformin; COVID-19; SARS-CoV-2; intestinal microbiota;
   immunoregulation
ID REGULATORY T-CELLS; CHAIN FATTY-ACIDS; BILE-SALT BIOTRANSFORMATIONS; GUT
   MICROBIOTA; AKKERMANSIA-MUCINIPHILA; ADAPTIVE IMMUNITY; TH17 CELLS;
   METFORMIN; INDUCTION; BACTERIA
AB Coronavirus disease 2019, or COVID-19, is a major challenge facing scientists worldwide. Alongside the lungs, the system of organs comprising the GI tract is commonly targeted by COVID-19. The dysbiotic modulations in the intestine influence the disease severity, potentially due to the ability of the intestinal microbiota to modulate T lymphocyte functions, i.e., to suppress or activate T cell subpopulations. The interplay between the lungs and intestinal microbiota is named the gut-lung axis. One of the most usual comorbidities in COVID-19 patients is type 2 diabetes, which induces changes in intestinal microbiota, resulting in a pro-inflammatory immune response, and consequently, a more severe course of COVID-19. However, changes in the microbiota in this comorbid pathology remain unclear. Metformin is used as a medication to treat type 2 diabetes. The use of the type 2 diabetes drug metformin is a promising treatment for this comorbidity because, in addition to its hypoglycemic action, it can increase amount of intestinal bacteria that induce regulatory T cell response. This dual activity of metformin can reduce lung damage and improve the course of the COVID-19 disease.
C1 [Petakh, Pavlo; Nykyforuk, Andriy] Uzhgorod Natl Univ, Dept Biochem & Pharmacol, UA-88000 Uzhgorod, Ukraine.
   [Petakh, Pavlo; Kamyshnyi, Aleksandr] I Horbachevsky Ternopil Natl Med Univ, Dept Microbiol Virol & Immunol, UA-46001 Ternopol, Ukraine.
   [Kamyshna, Iryna] I Horbachevsky Ternopil Natl Med Univ, Dept Med Rehabil, Majdan Voli 1, UA-46001 Ternopol, Ukraine.
   [Yao, Rouan] Norwegian Univ Sci & Technol, Ctr Mol Inflammat Res, Dept Clin & Mol Med, N-7491 Trondheim, Norway.
   [Imbery, John F.; Oksenych, Valentyn] Univ Oslo, Inst Clin Med, N-0318 Oslo, Norway.
   [Korda, Mykhaylo] I Horbachevsky Ternopil Natl Med Univ, Dept Med Biochem, UA-46001 Ternopol, Ukraine.
C3 Ministry of Education & Science of Ukraine; Uzhgorod National
   University; I. Horbachevsky Ternopil State Medical University; I.
   Horbachevsky Ternopil State Medical University; Norwegian University of
   Science & Technology (NTNU); University of Oslo; I. Horbachevsky
   Ternopil State Medical University
RP Kamyshnyi, A (通讯作者)，I Horbachevsky Ternopil Natl Med Univ, Dept Microbiol Virol & Immunol, UA-46001 Ternopol, Ukraine.; Oksenych, V (通讯作者)，Univ Oslo, Inst Clin Med, N-0318 Oslo, Norway.
EM pavlo.petakh@uzhnu.edu.ua; kamyshna_ii@tdmu.edu.ua; djsunray@gmail.com;
   rouan.yao@ntnu.no; j.f.imbery@medisin.uio.no;
   valentyn.oksenych@medisin.uio.no; kordamm@yahoo.com;
   kamyshnyi_om@tdmu.edu.ua
RI Oksenych, Valentyn/J-6216-2019; Nykyforuk, Andriy/AFR-7978-2022; PAVLO,
   PETAKH/ADN-8352-2022; Kamyshna, Iryna/C-6183-2017; Kamyshnyi,
   Aleksandr/B-8583-2015
OI Oksenych, Valentyn/0000-0002-5088-3791; Nykyforuk,
   Andriy/0000-0001-7590-4539; PAVLO, PETAKH/0000-0002-0860-4445; Kamyshna,
   Iryna/0000-0002-4483-1856; Kamyshnyi, Aleksandr/0000-0003-3141-4436;
   Imbery, John/0000-0002-0809-3550
CR Akbar AN, 2007, NAT REV IMMUNOL, V7, P231, DOI 10.1038/nri2037
   Al Nabhani Z, 2019, IMMUNITY, V50, P1276, DOI 10.1016/j.immuni.2019.02.014
   Anand S, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.02147
   Ansaldo E, 2019, SCIENCE, V364, P1179, DOI 10.1126/science.aaw7479
   Aoki R, 2017, SCI REP-UK, V7, DOI 10.1038/srep43522
   Asarat M, 2016, IMMUNOL INVEST, V45, P205, DOI 10.3109/08820139.2015.1122613
   Atarashi K, 2008, NATURE, V455, P808, DOI 10.1038/nature07240
   Atarashi K, 2017, SCIENCE, V358, P359, DOI 10.1126/science.aan4526
   Atarashi K, 2015, CELL, V163, P367, DOI 10.1016/j.cell.2015.08.058
   Atarashi K, 2013, NATURE, V500, P232, DOI 10.1038/nature12331
   Atarashi K, 2011, SCIENCE, V331, P337, DOI 10.1126/science.1198469
   Barengolts E, 2020, ENDOCR PRACT, V26, P1186, DOI 10.4158/EP-2020-0336
   Barengolts E, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0194171
   Baumgart DC, 2007, LANCET, V369, P1627, DOI 10.1016/S0140-6736(07)60750-8
   Blander JM, 2017, NAT IMMUNOL, V18, P851, DOI 10.1038/ni.3780
   Bornstein S, 2017, ENDOCRINOLOGY, V158, P3369, DOI 10.1210/en.2017-00299
   Braun J, 2020, NATURE, V587, P270, DOI 10.1038/s41586-020-2598-9
   Breyner NM, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.00114
   Bruzzese E, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0087796
   Bryrup T, 2019, DIABETOLOGIA, V62, P1024, DOI 10.1007/s00125-019-4848-7
   Budden KF, 2017, NAT REV MICROBIOL, V15, P55, DOI 10.1038/nrmicro.2016.142
   Candela M, 2016, BRIT J NUTR, V116, P80, DOI 10.1017/S0007114516001045
   Cani PD, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.01765
   Carter D, 2003, DIABETES OBES METAB, V5, P120, DOI 10.1046/j.1463-1326.2003.00252.x
   Chan JCN, 2020, LANCET, V396, P2019, DOI 10.1016/S0140-6736(20)32374-6
   Chavez-Carbajal A, 2020, MICROORGANISMS, V8, DOI 10.3390/microorganisms8010094
   Chen B, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.01403
   Chen YF, 2022, GUT, V71, P222, DOI 10.1136/gutjnl-2021-324090
   Chu HT, 2016, SCIENCE, V352, P1116, DOI 10.1126/science.aad9948
   Crome SQ, 2010, CLIN EXP IMMUNOL, V159, P109, DOI 10.1111/j.1365-2249.2009.04037.x
   Crotty S, 2011, ANNU REV IMMUNOL, V29, P621, DOI 10.1146/annurev-immunol-031210-101400
   Dasgupta S, 2014, CELL HOST MICROBE, V15, P413, DOI 10.1016/j.chom.2014.03.006
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Delzenne NM, 2015, DIABETOLOGIA, V58, P2206, DOI 10.1007/s00125-015-3712-7
   Devkota S, 2012, NATURE, V487, P104, DOI 10.1038/nature11225
   Diao B, 2020, FRONT IMMUNOL, V11, DOI 10.3389/fimmu.2020.00827
   [董小洁 Dong Xiaojie], 2018, [中国临床药理学与治疗学, Chinese Journal of Clinical Pharmacology and Therapeutics], V23, P488
   Dumas A, 2018, CELL MICROBIOL, V20, DOI 10.1111/cmi.12966
   Eckburg PB, 2005, SCIENCE, V308, P1635, DOI 10.1126/science.1110591
   Ejtahed HS, 2019, EUR J ENDOCRINOL, V180, P165, DOI [10.1530/EJE-18-0826, 10.1530/eje-18-0826]
   Elbere I, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0204317
   Enaud R, 2020, FRONT CELL INFECT MI, V10, DOI 10.3389/fcimb.2020.00009
   Feng T, 2011, MUCOSAL IMMUNOL, V4, P15, DOI 10.1038/mi.2010.60
   Ferreira-Halder CV, 2017, BEST PRACT RES CL GA, V31, P643, DOI 10.1016/j.bpg.2017.09.011
   Figueroa-Pizano MD, 2021, AIMS PUBLIC HEALTH, V8, P720, DOI 10.3934/publichealth.2021057
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Furusawa Y, 2013, NATURE, V504, P446, DOI 10.1038/nature12721
   Gallo O, 2021, MUCOSAL IMMUNOL, V14, P305, DOI 10.1038/s41385-020-00359-2
   Gao RY, 2018, OBESITY, V26, P351, DOI 10.1002/oby.22088
   Cano PG, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0041079
   Gauguet S, 2015, INFECT IMMUN, V83, P4003, DOI 10.1128/IAI.00037-15
   Geuking MB, 2011, IMMUNITY, V34, P794, DOI 10.1016/j.immuni.2011.03.021
   Gill SR, 2006, SCIENCE, V312, P1355, DOI 10.1126/science.1124234
   Golonka RM, 2020, PHYSIOL GENOMICS, V52, P217, DOI 10.1152/physiolgenomics.00033.2020
   Gomes-Neto JC, 2017, J MICROBIOL METH, V135, P52, DOI 10.1016/j.mimet.2017.02.003
   Goto Y, 2011, J IMMUNOL, V186
   Gozzi-Silva SC, 2021, FRONT NUTR, V8, DOI 10.3389/fnut.2021.674258
   Greer RL, 2016, NAT COMMUN, V7, DOI 10.1038/ncomms13329
   Gu SL, 2020, CLIN INFECT DIS, V71, P2669, DOI 10.1093/cid/ciaa709
   Gurung M, 2020, EBIOMEDICINE, V51, DOI 10.1016/j.ebiom.2019.11.051
   Haghikia A, 2015, IMMUNITY, V43, P817, DOI 10.1016/j.immuni.2015.09.007
   Hand T, 2010, CURR OPIN IMMUNOL, V22, P63, DOI 10.1016/j.coi.2010.01.008
   Hiel S, 2020, CLIN NUTR, V39, P3618, DOI 10.1016/j.clnu.2020.04.005
   Honda K, 2016, NATURE, V535, P75, DOI 10.1038/nature18848
   Huang F, 2018, INT J FOOD SCI NUTR, V69, P729, DOI 10.1080/09637486.2017.1408059
   Huda MN, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.632335
   Humphreys C, 2020, TXB NATURAL MED, P166, DOI [10.1016/b978-0-323-43044-9.00019-4, DOI 10.1016/B978-0-323-43044-9.00019-4]
   Ivanov II, 2009, CELL, V139, P485, DOI 10.1016/j.cell.2009.09.033
   Jagannathan-Bogdan M, 2011, J IMMUNOL, V186, P1162, DOI 10.4049/jimmunol.1002615
   Jin X, 2020, GUT, V69, P1002, DOI 10.1136/gutjnl-2020-320926
   Jones L., 2016, SCI REP-UK, V6, P1
   Jonsson H, 2020, COMMUN BIOL, V3, DOI 10.1038/s42003-020-01214-7
   Kamyshnyi O, 2021, BIOMED PHARMACOTHER, V144, DOI 10.1016/j.biopha.2021.112230
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kasubuchi M, 2015, NUTRIENTS, V7, P2839, DOI 10.3390/nu7042839
   Keely S, 2012, MUCOSAL IMMUNOL, V5, P7, DOI 10.1038/mi.2011.55
   Khan I, 2019, PATHOGENS, V8, DOI 10.3390/pathogens8030126
   Kikuchi K, 2018, BIOCHEM BIOPH RES CO, V501, P1041, DOI 10.1016/j.bbrc.2018.05.105
   Kimball A, 2020, PRELIMINARY ESTIMATE
   Kuczma MP, 2020, SCI ADV, V6, DOI 10.1126/sciadv.aaz3186
   Kuipers F, 2020, CELL METAB, V31, P445, DOI 10.1016/j.cmet.2020.02.006
   Kunisawa J, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0032094
   Lamers MM, 2020, SCIENCE, V369, P50, DOI 10.1126/science.abc1669
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Lavelle A, 2020, NAT REV GASTRO HEPAT, V17, P223, DOI 10.1038/s41575-019-0258-z
   Le KA, 2013, FRONT PHYSIOL, V3, DOI 10.3389/fphys.2012.00496
   Lee CH, 2021, NAT COMMUN, V12, DOI 10.1038/s41467-021-25807-w
   Lee H, 2018, GUT MICROBES, V9, P155, DOI 10.1080/19490976.2017.1405209
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Lee JY, 2020, CELL, V180, P79, DOI 10.1016/j.cell.2019.11.026
   Li GR, 2021, INT J ENDOCRINOL, V2021, DOI 10.1155/2021/7394378
   Li QW, 2018, MEDIAT INFLAMM, V2018, DOI 10.1155/2018/9830939
   Li W, 2021, CELL HOST MICROBE, V29, P1366, DOI 10.1016/j.chom.2021.07.013
   Lloyd-Price J, 2016, GENOME MED, V8, DOI 10.1186/s13073-016-0307-y
   Lopetuso LR, 2013, GUT PATHOG, V5, DOI 10.1186/1757-4749-5-23
   Lv LX, 2021, COMMUN BIOL, V4, DOI 10.1038/s42003-021-02036-x
   Lv LX, 2021, ANAL CHIM ACTA, V1152, DOI 10.1016/j.aca.2021.338267
   Maida A, 2011, DIABETOLOGIA, V54, P339, DOI 10.1007/s00125-010-1937-z
   Mannucci E, 2001, DIABETES CARE, V24, P489, DOI 10.2337/diacare.24.3.489
   Maslowski KM, 2011, NAT IMMUNOL, V12, P5, DOI 10.1038/ni0111-5
   Mazmanian SK, 2008, NATURE, V453, P620, DOI 10.1038/nature07008
   Mazmanian SK, 2005, CELL, V122, P107, DOI 10.1016/j.cell.2005.05.007
   Mazzarelli A, 2021, PLOS ONE, V16, DOI 10.1371/journal.pone.0247041
   Moya-Perez A, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0126976
   Mucida D, 2009, IMMUNITY, V30, P471, DOI 10.1016/j.immuni.2009.03.008
   Newsome RC, 2021, GUT MICROBES, V13, DOI 10.1080/19490976.2021.1926840
   Ohnmacht C, 2015, SCIENCE, V349, P989, DOI 10.1126/science.aac4263
   Pandiyan P, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.00426
   Venegas DP, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.00277
   Peck A, 2010, IMMUNOLOGY, V129, P147, DOI 10.1111/j.1365-2567.2009.03189.x
   Pedersen HK, 2016, NATURE, V535, P376, DOI 10.1038/nature18646
   Perruzza L, 2017, CELL REP, V18, P2566, DOI 10.1016/j.celrep.2017.02.061
   Perry RJ, 2016, NATURE, V534, P213, DOI 10.1038/nature18309
   Prasad Ram, 2021, bioRxiv, DOI 10.1101/2021.04.06.438634
   Putilin Denis Anatolievich, 2020, J Med Life, V13, P50, DOI 10.25122/jml-2020-0029
   Qin C, 2020, CLIN INFECT DIS, V71, P762, DOI 10.1093/cid/ciaa248
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Quevrain E, 2016, GUT, V65, P415, DOI 10.1136/gutjnl-2014-307649
   Rainey F., 2006, PROKARYOTES HDB BIOL, V3, P654
   Ranucci G, 2017, J IMMUNOL RES, V2017, DOI 10.1155/2017/8450496
   Ridlon JM, 2016, GUT MICROBES, V7, P22, DOI 10.1080/19490976.2015.1127483
   Ridlon JM, 2006, J LIPID RES, V47, P241, DOI 10.1194/jlr.R500013-JLR200
   Round JL, 2010, P NATL ACAD SCI USA, V107, P12204, DOI 10.1073/pnas.0909122107
   Sakaguchi S, 2005, NAT IMMUNOL, V6, P345, DOI 10.1038/ni1178
   Sato J, 2014, DIABETES CARE, V37, P2343, DOI 10.2337/dc13-2817
   Sedighi M, 2017, MICROB PATHOGENESIS, V111, P362, DOI 10.1016/j.micpath.2017.08.038
   Sefik E, 2015, SCIENCE, V349, P993, DOI 10.1126/science.aaa9420
   Sharma S, 2020, DIABETES RES CLIN PR, V164, DOI 10.1016/j.diabres.2020.108183
   Shen Y, 2012, CELL HOST MICROBE, V12, P509, DOI 10.1016/j.chom.2012.08.004
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Singh N, 2014, IMMUNITY, V40, P128, DOI 10.1016/j.immuni.2013.12.007
   Smith PM, 2013, SCIENCE, V341, P569, DOI 10.1126/science.1241165
   Sorini C, 2018, FRONT IMMUNOL, V9, DOI 10.3389/fimmu.2018.02667
   Stentz FB, 2003, CURR DRUG TARGETS, V4, P493, DOI 10.2174/1389450033490966
   Sun LC, 2017, FRONT IMMUNOL, V8, DOI 10.3389/fimmu.2017.01632
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Sze MA, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0111228
   Tan TG, 2016, P NATL ACAD SCI USA, V113, pE8141, DOI 10.1073/pnas.1617460113
   Tang LL, 2020, ENGINEERING-PRC, V6, P1178, DOI 10.1016/j.eng.2020.05.013
   Tang WHW, 2017, CIRC RES, V120, P1183, DOI 10.1161/CIRCRESAHA.117.309715
   Tanoue T, 2019, NATURE, V565, P600, DOI 10.1038/s41586-019-0878-z
   Telesford KM, 2015, GUT MICROBES, V6, P234, DOI 10.1080/19490976.2015.1056973
   Teng F, 2016, IMMUNITY, V44, P875, DOI 10.1016/j.immuni.2016.03.013
   Thaiss CA, 2016, NATURE, V535, P65, DOI 10.1038/nature18847
   Le TKC, 2015, BIOMED RES-TOKYO, V36, P63, DOI 10.2220/biomedres.36.63
   Tilg H, 2014, GUT, V63, P1513, DOI 10.1136/gutjnl-2014-306928
   Tirone C, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.02910
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Wang L, 2019, J IMMUNOL RES, V2019, DOI 10.1155/2019/4735040
   Wang M, 2018, CLIN IMMUNOL, V197, P77, DOI 10.1016/j.clim.2018.09.005
   Wu H, 2020, CELL METAB, V32, P379, DOI 10.1016/j.cmet.2020.06.011
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Wu XK, 2010, CURR MICROBIOL, V61, P69, DOI 10.1007/s00284-010-9582-9
   Wu ZY, 2020, JAMA-J AM MED ASSOC, V323, P1239, DOI 10.1001/jama.2020.2648
   Wyss M, 2020, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.03107
   Xu Kaijin, 2020, Zhejiang Da Xue Xue Bao Yi Xue Ban, V49, P147, DOI 10.3785/j.issn.1008-9292.2020.02.02
   Xu M., 2017, C MAF DEPENDENT REGU, DOI [10.1101/129601, DOI 10.1101/129601]
   Yamaguchi T, 2007, IMMUNITY, V27, P145, DOI 10.1016/j.immuni.2007.04.017
   Yang JY, 2017, MUCOSAL IMMUNOL, V10, P104, DOI 10.1038/mi.2016.42
   Yeoh YK, 2021, GUT, V70, P698, DOI 10.1136/gutjnl-2020-323020
   Yu Z., 2020, IMMUNODEPLETION HYPO, DOI [10.1101/2020.03.03.20030650, DOI 10.1101/2020.03.03.20030650]
   Yuan N, 2018, EXP CLIN ENDOCR DIAB, V126, P96, DOI 10.1055/s-0043-113454
   Zang RC, 2020, SCI IMMUNOL, V5, DOI 10.1126/sciimmunol.abc3582
   Zeng H, 2015, TRENDS IMMUNOL, V36, P3, DOI 10.1016/j.it.2014.08.003
   Zeng LY, 2012, DIABETES TECHNOL THE, V14, P35, DOI 10.1089/dia.2011.0123
   Zhang FH, 2019, ENDOCRINE, V66, P485, DOI 10.1007/s12020-019-02041-5
   Zhang Q, 2020, DIABET METAB SYND OB, V13, P5003, DOI 10.2147/DMSO.S286430
   Zhang Q, 2020, GENOME BIOL, V21, DOI 10.1186/s13059-020-02007-1
   Zhang XY, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0071108
   Zheng Y, 2008, NAT MED, V14, P282, DOI 10.1038/nm1720
   Zhou D, 2021, INT J INFECT DIS, V113, P300, DOI 10.1016/j.ijid.2021.09.013
   Zhou LX, 2018, INFLAMM BOWEL DIS, V24, P1926, DOI 10.1093/ibd/izy182
   Zhou T, 2018, J DIABETES RES, V2018, DOI 10.1155/2018/7457269
   Zhou W, 2020, J DIABETES RES, V2020, DOI 10.1155/2020/3918723
   Zhou ZY, 2016, ACTA PHARMACOL SIN, V37, P1063, DOI 10.1038/aps.2016.21
   Zuo T, 2020, GASTROENTEROLOGY, V159, P944, DOI 10.1053/j.gastro.2020.05.048
NR 176
TC 7
Z9 7
U1 1
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1999-4915
J9 VIRUSES-BASEL
JI Viruses-Basel
PD MAR
PY 2022
VL 14
IS 3
AR 477
DI 10.3390/v14030477
PG 21
WC Virology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Virology
GA 0B1PW
UT WOS:000774415100001
PM 35336884
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Kyriachenko, Y
   Falalyeyeva, T
   Korotkyi, O
   Molochek, N
   Kobyliak, N
AF Kyriachenko, Yevheniia
   Falalyeyeva, Tetyana
   Korotkyi, Oleksandr
   Molochek, Nataliia
   Kobyliak, Nazarii
TI Crosstalk between gut microbiota and antidiabetic drug action
SO WORLD JOURNAL OF DIABETES
LA English
DT Review
DE Type 2 diabetes; Gut microbiota; Metformin; alpha-glucosidase
   inhibitors; Glucagon-like peptide-1 agonists; Peroxisome
   proliferator-activated receptors gamma agonists; Dipeptidyl peptidase-4
   inhibitors; Sodium/glucose cotransporter inhibitors
ID GLUCAGON-LIKE PEPTIDE-1; CHAIN FATTY-ACIDS; AKKERMANSIA-MUCINIPHILA;
   INSULIN SENSITIVITY; GLUCOSE-TOLERANCE; LIPID-METABOLISM; DOUBLE-BLIND;
   BODY-WEIGHT; DIET; METFORMIN
AB Type 2 diabetes (T2D) is a disorder characterized by chronic inflated blood glucose levels (hyperglycemia), at first due to insulin resistance and unregulated insulin secretion but with tendency towards global spreading. The gut microbiota is recognized to have an influence on T2D, although surveys have not formed a clear overview to date. Because of the interactions between gut microbiota and host homeostasis, intestinal bacteria are believed to play a large role in various diseases, including metabolic syndrome, obesity and associated disease. In this review, we highlight the animal and human studies which have elucidated the roles of metformin, alpha-glucosidase inhibitors, glucagon-like peptide-1 agonists, peroxisome proliferator-activated receptors gamma agonists, inhibitors of dipeptidyl peptidase-4, sodium/glucose cotransporter inhibitors, and other less studied medications on gut microbiota. This review is dedicated to one of the most widespread diseases, T2D, and the currently used antidiabetic drugs and most promising new findings. In general, the gut microbiota has been shown to have an influence on host metabolism, food consumption, satiety, glucose homoeostasis, and weight gain. Altered intestinal microbiota composition has been noticed in cardiovascular diseases, colon cancer, rheumatoid arthritis, T2D, and obesity. Therefore, the main effect of antidiabetic drugs is on the microbiome composition, basically increasing the short-chain fatty acids-producing bacteria, responsible for losing weight and suppressing inflammation.
C1 [Kyriachenko, Yevheniia; Falalyeyeva, Tetyana; Korotkyi, Oleksandr; Molochek, Nataliia] Taras Shevchenko Natl Univ Kyiv, Inst Biol & Med, Educ & Sci Ctr, UA-01601 Kiev, Ukraine.
   [Kobyliak, Nazarii] Bogomolets Natl Med Univ, Endocrinol Dept, Pushkinska 22a Str, UA-01601 Kiev, Ukraine.
C3 Ministry of Education & Science of Ukraine; Taras Shevchenko National
   University Kiev; Bogomolets National Medical University
RP Kobyliak, N (通讯作者)，Bogomolets Natl Med Univ, Endocrinol Dept, Pushkinska 22a Str, UA-01601 Kiev, Ukraine.
EM nazariikobyliak@gmail.com
RI Falalyeyeva, Tetyana/Z-3076-2019; Korotkyi, Oleksandr/AAZ-6512-2020;
   Kobyliak, Nazarii/R-8703-2016
OI Falalyeyeva, Tetyana/0000-0002-4415-9676; Korotkyi,
   Oleksandr/0000-0003-1147-532X; Kobyliak, Nazarii/0000-0001-9814-689X;
   Kyriachenko, Yevheniia/0000-0002-4771-1702
CR Ahmed RH, 2017, CLIN BIOCHEM, V50, P746, DOI 10.1016/j.clinbiochem.2017.03.008
   Alex S, 2013, MOL CELL BIOL, V33, P1303, DOI 10.1128/MCB.00858-12
   Amato A, 2010, NEUROGASTROENT MOTIL, V22, P664, DOI 10.1111/j.1365-2982.2010.01476.x
   Anghel SI, 2007, CELL RES, V17, P486, DOI 10.1038/cr.2007.48
   Aoki R, 2017, SCI REP-UK, V7, DOI 10.1038/srep43522
   Are A, 2008, P NATL ACAD SCI USA, V105, P1943, DOI 10.1073/pnas.0711734105
   Battson ML, 2018, AM J PHYSIOL-ENDOC M, V314, pE468, DOI 10.1152/ajpendo.00187.2017
   Blandino G, 2016, DIABETES METAB, V42, P303, DOI 10.1016/j.diabet.2016.04.004
   Brown PH, 2000, BREAST CANCER RES TR, V62, P1, DOI 10.1023/A:1006484604454
   Brunkwall L, 2017, DIABETOLOGIA, V60, P943, DOI 10.1007/s00125-017-4278-3
   Byron JS, 2018, MICROBIOME, DOI [10.1101/311456, DOI 10.1101/311456]
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   Cani PD, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.01765
   Cani PD, 2005, OBES RES, V13, P1000, DOI 10.1038/oby.2005.117
   Chiasson JL, 2002, LANCET, V359, P2072, DOI 10.1016/S0140-6736(02)08905-5
   Chiasson JL, 2003, JAMA-J AM MED ASSOC, V290, P486, DOI 10.1001/jama.290.4.486
   Clemmensen C, 2013, ENDOCRINOLOGY, V154, P3978, DOI 10.1210/en.2013-1529
   Devaraj S, 2016, CLIN CHEM, V62, P1554, DOI 10.1373/clinchem.2016.256842
   Diouf I, 2011, EUR J EPIDEMIOL, V26, P789, DOI 10.1007/s10654-011-9599-9
   Do HJ, 2016, ENDOCR J, V63, P691, DOI 10.1507/endocrj.EJ15-0747
   Do HJ, 2014, BIOCHEM BIOPH RES CO, V443, P1110, DOI 10.1016/j.bbrc.2013.12.120
   Drucker DJ, 2006, LANCET, V368, P1696, DOI 10.1016/S0140-6736(06)69705-5
   Du FY, 2018, J PHARMACOL EXP THER, V365, P676, DOI 10.1124/jpet.118.248575
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Everard A, 2011, DIABETES, V60, P2775, DOI 10.2337/db11-0227
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Fteita D, 2017, ANAEROBE, V48, P152, DOI 10.1016/j.anaerobe.2017.08.009
   Gao ZG, 2009, DIABETES, V58, P1509, DOI 10.2337/db08-1637
   Grasset E, 2017, CELL METAB, V25, P1075, DOI 10.1016/j.cmet.2017.04.013
   Grimaldi PA, 2007, CELL MOL LIFE SCI, V64, P2459, DOI 10.1007/s00018-007-7278-5
   Gu YY, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-01682-2
   Hellstrom PM, 2009, ALIMENT PHARM THER, V29, P198, DOI 10.1111/j.1365-2036.2008.03870.x
   Heppner KM, 2015, ENDOCRINOLOGY, V156, P255, DOI 10.1210/en.2014-1675
   Holzer P, 2012, NEUROPEPTIDES, V46, P261, DOI 10.1016/j.npep.2012.08.005
   Hur KY, 2015, J DIABETES INVEST, V6, P600, DOI 10.1111/jdi.12328
   Jourova L, 2016, BIOMED PAP, V160, P317, DOI 10.5507/bp.2016.039
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kim J, 2014, J CLIN INVEST, V124, P3311, DOI 10.1172/JCI69625
   Kim MH, 2013, GASTROENTEROLOGY, V145, P396, DOI 10.1053/j.gastro.2013.04.056
   Kishida Y, 2017, J GASTROENTEROL, V52, P1180, DOI 10.1007/s00535-017-1331-4
   Klemann C, 2016, CLIN EXP IMMUNOL, V185, P1, DOI 10.1111/cei.12781
   Kobyliak N, 2018, DIABETES RES CLIN PR, V141, P190, DOI 10.1016/j.diabres.2018.05.005
   Kobyliak N, 2018, MINERVA MED, V109, P418, DOI 10.23736/S0026-4806.18.05845-7
   Kobyliak N, 2018, DIABETES METAB SYND, V12, P617, DOI 10.1016/j.dsx.2018.04.015
   Kobyliak N, 2018, J GASTROINTEST LIVER, V27, P41, DOI 10.15403/jgld.2014.1121.271.kby
   Kobyliak N, 2018, ANN HEPATOL, V17, P153, DOI 10.5604/01.3001.0010.7547
   Kobyliak N, 2017, ENDOKRYNOL POL, V68, P659, DOI 10.5603/EP.a2017.0055
   Kobyliak N, 2017, PROBIOTICS ANTIMICRO, V9, P123, DOI 10.1007/s12602-016-9230-1
   Kobyliak N, 2016, NUTR J, V15, DOI 10.1186/s12937-016-0166-9
   Kobyliak N, 2016, BMC GASTROENTEROL, V16, DOI 10.1186/s12876-016-0451-2
   Koh A, 2016, CELL, V165, P1332, DOI 10.1016/j.cell.2016.05.041
   Kumar PS, 2003, J DENT RES, V82, P338, DOI 10.1177/154405910308200503
   Kuo GH, 2018, BIOORG MED CHEM LETT, V28, P1182, DOI 10.1016/j.bmcl.2018.02.057
   Lee DM, 2018, CARDIOVASC DIABETOL, V17, DOI 10.1186/s12933-018-0708-x
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Lefterova MI, 2009, TRENDS ENDOCRIN MET, V20, P107, DOI 10.1016/j.tem.2008.11.005
   Liao YL, 2006, CARDIOVASC RES, V70, P107, DOI 10.1016/j.cardiores.2006.01.021
   Lieber CS, 2004, BIOCHEM BIOPH RES CO, V315, P699, DOI 10.1016/j.bbrc.2004.01.116
   Lim YM, 2014, NAT COMMUN, V5, DOI 10.1038/ncomms5934
   Liou AP, 2013, SCI TRANSL MED, V5, DOI 10.1126/scitranslmed.3005687
   Montandon SA, 2017, GENES-BASEL, V8, DOI 10.3390/genes8100250
   Mudaliar S, 2015, DIABETES CARE, V38, P2344, DOI 10.2337/dc15-0642
   Murphy EF, 2010, GUT, V59, P1635, DOI 10.1136/gut.2010.215665
   Mykhalchyshyn G, 2015, J DIABETES METAB DIS, V14, DOI 10.1186/s40200-015-0170-1
   Napolitano A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100778
   Nepelska M, 2017, SCI REP-UK, V7, DOI 10.1038/srep43199
   Neschen S, 2007, DIABETES, V56, P1034, DOI 10.2337/db06-1206
   Newman DJ, 2012, J NAT PROD, V75, P311, DOI 10.1021/np200906s
   Nozu T, 2018, J GASTROEN HEPATOL, V33, P232, DOI 10.1111/jgh.13808
   Olivares M, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.01900
   Sahagun DO, 2012, PPAR RES, V2012, DOI 10.1155/2012/318613
   Panwar H, 2014, EUR J NUTR, V53, P1465, DOI 10.1007/s00394-013-0649-9
   Paul HA, 2016, SCI REP-UK, V6, DOI 10.1038/srep20683
   Pernicova I, 2014, NAT REV ENDOCRINOL, V10, P143, DOI 10.1038/nrendo.2013.256
   Puddu Alessandra, 2014, Mediators Inflamm, V2014, P162021, DOI 10.1155/2014/162021
   Puglisi MJ, 2011, J NUTR BIOCHEM, V22, P101, DOI 10.1016/j.jnutbio.2010.07.003
   Pyke C, 2014, ENDOCRINOLOGY, V155, P1280, DOI 10.1210/en.2013-1934
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Rizos CV, 2009, EXPERT OPIN DRUG SAF, V8, P15, DOI [10.1517/14740330802597821 , 10.1517/14740330802597821]
   Roopchand DE, 2015, DIABETES, V64, P2847, DOI 10.2337/db14-1916
   Ryan PM, 2018, CAN J DIABETES, V42, pS40, DOI [10.1016/j.jcjd.2018.08.120, DOI 10.1016/J.JCJD.2018.08.120]
   Scher JU, 2013, ELIFE, V2, DOI 10.7554/eLife.01202
   Schwiertz A, 2010, OBESITY, V18, P190, DOI 10.1038/oby.2009.167
   Seino Y, 2010, J DIABETES INVEST, V1, P1, DOI 10.1111/j.2040-1124.2010.00005.x
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Stengel A, 2014, PEPTIDES, V61, P75, DOI 10.1016/j.peptides.2014.09.006
   Suzuki Y, 2009, FEBS LETT, V583, P2157, DOI 10.1016/j.febslet.2009.05.052
   Tan KM, 2018, PROTEIN SCI, V27, P1498, DOI 10.1002/pro.3444
   Tilg H, 2014, GUT, V63, P1513, DOI 10.1136/gutjnl-2014-306928
   Turnbaugh PJ, 2009, NATURE, V457, P480, DOI 10.1038/nature07540
   Vettorazzi JF, 2016, METABOLISM, V65, P54, DOI 10.1016/j.metabol.2015.10.021
   Vieira ELM, 2012, J NUTR BIOCHEM, V23, P430, DOI 10.1016/j.jnutbio.2011.01.007
   Vilsboll T, 2012, BMJ-BRIT MED J, V344, DOI 10.1136/bmj.d7771
   Viollet B, 2012, CLIN SCI, V122, P253, DOI 10.1042/CS20110386
   Voss U, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0081413
   Vrieze A, 2010, DIABETOLOGIA, V53, P606, DOI 10.1007/s00125-010-1662-7
   Wang L, 2016, SCI REP-UK, V6, DOI [10.1038/srep38380, 10.1038/srep33251, 10.1038/srep20004]
   Wang Zhang, 2018, Endocrinol Diabetes Metab, V1, pe00009, DOI 10.1002/edm2.9
   Woting A, 2016, NUTRIENTS, V8, DOI 10.3390/nu8040202
   Wu BN, 2011, J NUTR METAB, V2011, DOI 10.1155/2011/391809
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Wu TR, 2019, GUT, V68, P248, DOI 10.1136/gutjnl-2017-315458
   Xu J, 2015, ISME J, V9, P552, DOI 10.1038/ismej.2014.177
   Yoo HH, 2016, J HYPERTENS, V34, P156, DOI 10.1097/HJH.0000000000000773
   Yoshizawa K, 2002, CANCER-AM CANCER SOC, V95, P2243, DOI 10.1002/cncr.10906
   Zambrowicz B, 2013, CLIN THER, V35, P273, DOI 10.1016/j.clinthera.2013.01.010
   Zhang HS, 2009, P NATL ACAD SCI USA, V106, P2365, DOI 10.1073/pnas.0812600106
   Zhang Q, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0184735
   Zhang XY, 2017, DIABETES THER, V8, P293, DOI 10.1007/s13300-017-0226-y
   Zhang XY, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0071108
   Zhang X, 2015, SCI REP-UK, V5, DOI 10.1038/srep14405
   Zhao L, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00233
   Zhong JX, 2015, J DIABETES RES, V2015, DOI 10.1155/2015/606031
NR 113
TC 41
Z9 45
U1 0
U2 23
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
EI 1948-9358
J9 WORLD J DIABETES
JI World J. Diabetes
PD MAR 15
PY 2019
VL 10
IS 3
BP 154
EP 168
DI 10.4239/wjd.v10.i3.154
PG 15
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA HP3SV
UT WOS:000461598700003
PM 30891151
OA Green Submitted, Green Published, gold
DA 2023-06-08
ER

PT J
AU Montandon, SA
   Jornayvaz, FR
AF Montandon, Sophie A.
   Jornayvaz, Francois R.
TI Effects of Antidiabetic Drugs on Gut Microbiota Composition
SO GENES
LA English
DT Review
DE gut microbiota; type 2 diabetes; antidiabetic drugs; metformin;
   incretins
ID CHAIN FATTY-ACIDS; INTESTINAL MICROBIOTA; BILE-ACIDS; METFORMIN; DIET;
   GLUCAGON; METABOLISM; ACARBOSE; ALTERS; IMPACT
AB Gut microbiota forms a catalog of about 1000 bacterial species; which mainly belong to the Firmicutes and Bacteroidetes phyla. Microbial genes are essential for key metabolic processes; such as the biosynthesis of short-chain fatty acids (SCFA); amino acids; bile acids or vitamins. It is becoming clear that gut microbiota is playing a prevalent role in pathologies such as metabolic syndrome; type 2 diabetes (T2D); inflammatory and bowel diseases. Obesity and related diseases; notably type 2 diabetes, induce gut dysbiosis. In this review; we aim to cover the current knowledge about the effects of antidiabetic drugs on gut microbiota diversity and composition as well as the potential beneficial effects mediated by specific taxa. Metformin is the first-line treatment against T2D. In addition to its glucose-lowering and insulin sensitizing effects, metformin promotes SCFA-producing and mucin-degrading bacteria. Other antidiabetic drugs discussed in this review show positive effects on dysbiosis; but without any consensus specifically regarding the Firmicutes to Bacteroidetes ratio. Thus, beneficial effects might be mediated by specific taxa.
C1 [Montandon, Sophie A.; Jornayvaz, Francois R.] Geneva Univ Hosp, Serv Endocrinol Diabet Hypertens & Nutr, Rue Gabrielle Perret Gentil 4, CH-1205 Geneva, Switzerland.
C3 University of Geneva
RP Jornayvaz, FR (通讯作者)，Geneva Univ Hosp, Serv Endocrinol Diabet Hypertens & Nutr, Rue Gabrielle Perret Gentil 4, CH-1205 Geneva, Switzerland.
EM sophie.montandon@unige.ch; francois.jornayvaz@hcuge.ch
RI Jornayvaz, François/AAL-2134-2020
OI Jornayvaz, Francois/0000-0001-9425-3137
FU Gottfried and Julia Bangerter-Rhyner Foundation; Foundation of the Swiss
   Diabetes Association; Novo Nordisk
FX F.R.J. is supported by grants from the Gottfried and Julia
   Bangerter-Rhyner Foundation, the Foundation of the Swiss Diabetes
   Association, and by an unrestricted grant from Novo Nordisk.
CR Araujo JR, 2017, BIOCHIMIE, V141, P97, DOI 10.1016/j.biochi.2017.05.019
   Arora T, 2016, J INTERN MED, V280, P339, DOI 10.1111/joim.12508
   Asrih M, 2015, MOL CELL ENDOCRINOL, V418, P55, DOI 10.1016/j.mce.2015.02.018
   Bai J, 2016, J ETHNOPHARMACOL, V194, P717, DOI 10.1016/j.jep.2016.10.043
   Baothman OA, 2016, LIPIDS HEALTH DIS, V15, DOI 10.1186/s12944-016-0278-4
   Becker N, 2011, GUT MICROBES, V2, P25, DOI 10.4161/gmic.2.1.14651
   Berger JP, 2005, TRENDS PHARMACOL SCI, V26, P244, DOI 10.1016/j.tips.2005.03.003
   BERGMAN EN, 1990, PHYSIOL REV, V70, P567, DOI 10.1152/physrev.1990.70.2.567
   Blaut M, 2015, P NUTR SOC, V74, P227, DOI 10.1017/S0029665114001700
   BONORA E, 1984, CURR MED RES OPIN, V9, P47, DOI 10.1185/03007998409109558
   Boulange CL, 2016, GENOME MED, V8, DOI 10.1186/s13073-016-0303-2
   Brunkhorst C, 1999, J BACTERIOL, V181, P2612, DOI 10.1128/JB.181.8.2612-2619.1999
   Brunkwall L, 2017, DIABETOLOGIA, V60, P943, DOI 10.1007/s00125-017-4278-3
   Cabreiro F, 2013, CELL, V153, P228, DOI 10.1016/j.cell.2013.02.035
   Cani PD, 2009, CURR PHARM DESIGN, V15, P1546, DOI 10.2174/138161209788168164
   Chassaing B, 2014, TOXICOL PATHOL, V42, P49, DOI 10.1177/0192623313508481
   Clarke G, 2014, MOL ENDOCRINOL, V28, P1221, DOI 10.1210/me.2014-1108
   David LA, 2014, NATURE, V505, P559, DOI 10.1038/nature12820
   De Filippo C, 2010, P NATL ACAD SCI USA, V107, P14691, DOI 10.1073/pnas.1005963107
   Deacon CF, 1996, AM J PHYSIOL-ENDOC M, V271, pE458, DOI 10.1152/ajpendo.1996.271.3.E458
   DELACUESTAZULUA.J, 2017, GUT DIABETES CARE, V40, P54, DOI DOI 10.2337/DC16-1324
   Derrien M, 2004, INT J SYST EVOL MICR, V54, P1469, DOI 10.1099/ijs.0.02873-0
   Do HJ, 2016, ENDOCR J, V63, P691, DOI 10.1507/endocrj.EJ15-0747
   Drucker DJ, 2006, LANCET, V368, P1696, DOI 10.1016/S0140-6736(06)69705-5
   Drucker DJ, 2006, CELL METAB, V3, P153, DOI 10.1016/j.cmet.2006.01.004
   Eckburg PB, 2005, SCIENCE, V308, P1635, DOI 10.1126/science.1110591
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Evans CC, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0092193
   Everard A, 2014, REV ENDOCR METAB DIS, V15, P189, DOI 10.1007/s11154-014-9288-6
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Fukui H, 2016, J CLIN NUTR DIETETIC, V2, DOI [10.4172/2472-1921.100027, DOI 10.4172/2472-1921.100027]
   Gabel SA, 2017, BIOCHEMISTRY-US, V56, P4786, DOI 10.1021/acs.biochem.7b00619
   Garber Alan J, 2011, Rev Diabet Stud, V8, P307, DOI 10.1900/RDS.2011.8.307
   Hamer HM, 2008, ALIMENT PHARM THER, V27, P104, DOI 10.1111/j.1365-2036.2007.03562.x
   Huo TG, 2015, BIOMED CHROMATOGR, V29, P115, DOI 10.1002/bmc.3247
   Jain AK, 2012, BIOORGAN MED CHEM, V20, P3378, DOI 10.1016/j.bmc.2012.03.069
   Jornayvaz FR, 2010, ANNU REV NUTR, V30, P273, DOI 10.1146/annurev.nutr.012809.104726
   Kalra S, 2013, J PAK MED ASSOC, V63, P1312
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kishida Y, 2017, J GASTROENTEROL, V52, P1180, DOI 10.1007/s00535-017-1331-4
   Krych L, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0062578
   LADAS SD, 1992, GUT, V33, P1246, DOI 10.1136/gut.33.9.1246
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Ley RE, 2005, P NATL ACAD SCI USA, V102, P11070, DOI 10.1073/pnas.0504978102
   Ley RE, 2006, NATURE, V444, P1022, DOI 10.1038/4441022a
   Long SL, 2017, MOL ASPECTS MED, V56, P54, DOI 10.1016/j.mam.2017.06.002
   Louis P, 2010, ENVIRON MICROBIOL, V12, P304, DOI 10.1111/j.1462-2920.2009.02066.x
   Macfarlane S, 2003, P NUTR SOC, V62, P67, DOI 10.1079/PNS2002207
   MARUHAMA Y, 1980, TOHOKU J EXP MED, V132, P453, DOI 10.1620/tjem.132.453
   Matsumoto M, 2008, BIOSCI BIOTECH BIOCH, V72, P572, DOI 10.1271/bbb.70474
   Mentlein R, 2009, BEST PRACT RES CL EN, V23, P443, DOI 10.1016/j.beem.2009.03.005
   Monda V, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/3831972
   Morrison DJ, 2016, GUT MICROBES, V7, P189, DOI 10.1080/19490976.2015.1134082
   Murphy EF, 2010, GUT, V59, P1635, DOI 10.1136/gut.2010.215665
   Napolitano A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100778
   Pappachan JM, 2017, CURR DIABETES REP, V17, DOI 10.1007/s11892-017-0828-9
   Pernicova I, 2014, NAT REV ENDOCRINOL, V10, P143, DOI 10.1038/nrendo.2013.256
   Qin JJ, 2010, NATURE, V464, P59, DOI 10.1038/nature08821
   Ridlon JM, 2014, CURR OPIN GASTROEN, V30, P332, DOI 10.1097/MOG.0000000000000057
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Staley C, 2017, APPL MICROBIOL BIOT, V101, P47, DOI 10.1007/s00253-016-8006-6
   Su BL, 2015, J DIABETES, V7, P729, DOI 10.1111/1753-0407.12232
   Nguyen TLA, 2015, DIS MODEL MECH, V8, P1, DOI 10.1242/dmm.017400
   Tolhurst G, 2012, DIABETES, V61, P364, DOI 10.2337/db11-1019
   Tremaroli V, 2012, NATURE, V489, P242, DOI 10.1038/nature11552
   Turnbaugh PJ, 2009, SCI TRANSL MED, V1, DOI 10.1126/scitranslmed.3000322
   Turnbaugh PJ, 2009, NATURE, V457, P480, DOI 10.1038/nature07540
   Vilsboll T, 2012, BMJ-BRIT MED J, V344, DOI 10.1136/bmj.d7771
   Viollet B, 2012, CLIN SCI, V122, P253, DOI 10.1042/CS20110386
   Wang L, 2016, SCI REP-UK, V6, DOI [10.1038/srep38380, 10.1038/srep33251, 10.1038/srep20004]
   Weaver GA, 1997, J NUTR, V127, P717, DOI 10.1093/jn/127.5.717
   Wehmeier UF, 2004, APPL MICROBIOL BIOT, V63, P613, DOI 10.1007/s00253-003-1477-2
   Woting A, 2016, NUTRIENTS, V8, DOI 10.3390/nu8040202
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Yan XF, 2016, J DIABETES RES, V2016, DOI 10.1155/2016/2093171
   Yatsunenko T, 2012, NATURE, V486, P222, DOI 10.1038/nature11053
   Zhang CH, 2010, ISME J, V4, P232, DOI 10.1038/ismej.2009.112
   ZHANG X, 2017, CONTROLLED CROSSOVER, V8, P293, DOI DOI 10.1007/S13300-017-0226-Y
   Zhang XY, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0071108
   Zhang X, 2015, SCI REP-UK, V5, DOI 10.1038/srep14405
NR 80
TC 82
Z9 90
U1 3
U2 31
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2073-4425
J9 GENES-BASEL
JI Genes
PD OCT
PY 2017
VL 8
IS 10
AR 250
DI 10.3390/genes8100250
PG 12
WC Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity
GA FM2WI
UT WOS:000414862300015
PM 28973971
OA Green Submitted, Green Published, gold
DA 2023-06-08
ER

PT J
AU Caesar, R
AF Caesar, Robert
TI Pharmacologic and Nonpharmacologic Therapies for the Gut Microbiota in
   Type 2 Diabetes
SO CANADIAN JOURNAL OF DIABETES
LA English
DT Review
DE diabetes; glucose metabolism; gut microbiota; metagenome; metformin;
   short-chain fatty acids
ID INTESTINAL MICROBIOTA; DIETARY FIBER; BILE-ACIDS;
   AKKERMANSIA-MUCINIPHILA; INSULIN SENSITIVITY; METABOLIC SYNDROME;
   METFORMIN ALTERS; GLUCOSE; IMPACT; BARRIER
AB The gut microbiota is an important regulator of host metabolism. Metagenome analyses have demonstrated that the gut microbiota differs between patients with type 2 diabetes and healthy subjects, and several studies have shown that impaired glucose metabolism is associated with decreased levels of butyrate-producing bacteria. Gut microbiota-produced metabolites, such as short-chain fatty acids, amino acid derivatives and secondary bile acids, participate in metabolic and immunologic processes and, hence, pose putative links between the gut microbiota and glucose homeostasis. Strategies to prevent and treat type 2 diabetes through manipulation of the gut microbiota are being developed. These include replacement of the gut microbiota by fecal transplantation, consumption of fibres to promote the function and growth of beneficial bacteria and treatment with probiotic bacterial strains. Furthermore, it has been shown that many drugs, including drugs used for treatment of diabetes, have major impacts on gut microbiota and, thereby, potentially on glucose metabolism. In particular, the commonly used drug metformin has been shown to influence the functional capacity of the gut microbiota, and recent evidence indicates that this may contribute to the antidiabetes effect of metformin. (C) 2019 Canadian Diabetes Association.
C1 [Caesar, Robert] Univ Gothenburg, Dept Mol & Clin Med, Wallenberg Lab, S-41345 Gothenburg, Sweden.
C3 University of Gothenburg
RP Caesar, R (通讯作者)，Univ Gothenburg, Dept Mol & Clin Med, Wallenberg Lab, S-41345 Gothenburg, Sweden.
EM Robert.Caesar@wlab.gu.se
RI Caesar, Robert/AAX-3205-2020
FU Swedish Research Council Formas [2017-02001]
FX I thank A. Wahlstrom, V. Tremaroli and K. Krautkramer for reading and
   commenting on the manuscript. I also thank A. Hallen for her assistance
   with figures and artwork. Work in the authors' laboratory is supported
   by The Swedish Research Council Formas (2017-02001).
CR Agarwal P, 2014, PHARM RES-DORDR, V31, P3404, DOI 10.1007/s11095-014-1430-3
   Allin KH, 2018, DIABETOLOGIA, V61, P810, DOI 10.1007/s00125-018-4550-1
   Bauer PV, 2018, CELL METAB, V27, P101, DOI 10.1016/j.cmet.2017.09.019
   Burcelin R, 2016, MOL METAB, V5, P771, DOI 10.1016/j.molmet.2016.05.016
   Byndloss MX, 2017, SCIENCE, V357, P570, DOI 10.1126/science.aam9949
   Caesar R, 2015, CELL METAB, V22, P658, DOI 10.1016/j.cmet.2015.07.026
   Caesar R, 2012, GUT, V61, P1701, DOI 10.1136/gutjnl-2011-301689
   Chandalia M, 2000, NEW ENGL J MED, V342, P1392, DOI 10.1056/NEJM200005113421903
   Chang PV, 2014, P NATL ACAD SCI USA, V111, P2247, DOI 10.1073/pnas.1322269111
   Chen HQ, 2010, AM J PHYSIOL-GASTR L, V299, pG1287, DOI 10.1152/ajpgi.00196.2010
   Creely SJ, 2007, AM J PHYSIOL-ENDOC M, V292, pE740, DOI 10.1152/ajpendo.00302.2006
   Dao MC, 2016, GUT, V65, P426, DOI 10.1136/gutjnl-2014-308778
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   DeFronzo RA, 2016, DIABETOLOGIA, V59, P1645, DOI 10.1007/s00125-016-3992-6
   Desai MS, 2016, CELL, V167, P1339, DOI 10.1016/j.cell.2016.10.043
   Donaldson GP, 2016, NAT REV MICROBIOL, V14, P20, DOI 10.1038/nrmicro3552
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Flint HJ, 2012, NAT REV GASTRO HEPAT, V9, P577, DOI 10.1038/nrgastro.2012.156
   Flowers SA, 2017, PHARMACOTHERAPY, V37, P261, DOI 10.1002/phar.1890
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Gu YY, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-01682-2
   Henao-Mejia J, 2012, NATURE, V482, P179, DOI 10.1038/nature10809
   Huang F, 2018, INT J FOOD SCI NUTR, V69, P729, DOI 10.1080/09637486.2017.1408059
   Imhann F, 2016, GUT, V65, P740, DOI 10.1136/gutjnl-2015-310376
   Jandhyala SM, 2015, WORLD J GASTROENTERO, V21, P8787, DOI 10.3748/wjg.v21.i29.8787
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Koh A, 2018, CELL, V175, P947, DOI 10.1016/j.cell.2018.09.055
   Koh A, 2016, CELL, V165, P1332, DOI 10.1016/j.cell.2016.05.041
   Kootte RS, 2017, CELL METAB, V26, P611, DOI 10.1016/j.cmet.2017.09.008
   Kovatcheva-Datchary P, 2015, CELL METAB, V22, P971, DOI 10.1016/j.cmet.2015.10.001
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Li JH, 2014, NAT BIOTECHNOL, V32, P834, DOI 10.1038/nbt.2942
   Liu B, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0106184
   Maier L, 2018, NATURE, V555, P623, DOI 10.1038/nature25979
   Makki K, 2018, CELL HOST MICROBE, V23, P705, DOI 10.1016/j.chom.2018.05.012
   Meng XM, 2017, EUR REV MED PHARMACO, V21, P2232
   Montandon SA, 2017, GENES-BASEL, V8, DOI 10.3390/genes8100250
   Napolitano A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100778
   Natividad JMM, 2013, PHARMACOL RES, V69, P42, DOI 10.1016/j.phrs.2012.10.007
   Parnell JA, 2017, OBESITY, V25, P510, DOI 10.1002/oby.21763
   Pedersen HK, 2016, NATURE, V535, P376, DOI 10.1038/nature18646
   Plovier H, 2017, NAT MED, V23, P107, DOI 10.1038/nm.4236
   Portune KJ, 2016, TRENDS FOOD SCI TECH, V57, P213, DOI 10.1016/j.tifs.2016.08.011
   Pyra KA, 2012, J NUTR, V142, P213, DOI 10.3945/jn.111.147132
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Qin JJ, 2010, NATURE, V464, P59, DOI 10.1038/nature08821
   Rajilic-Stojanovic M, 2014, FEMS MICROBIOL REV, V38, P996, DOI 10.1111/1574-6976.12075
   Reunanen J, 2015, APPL ENVIRON MICROB, V81, P3655, DOI 10.1128/AEM.04050-14
   Ridaura VK, 2013, SCIENCE, V341, P1079, DOI 10.1126/science.1241214
   Rogers MAM, 2016, CLIN MICROBIOL INFEC, V22, DOI 10.1016/j.cmi.2015.10.003
   Rowland I, 2018, EUR J NUTR, V57, P1, DOI 10.1007/s00394-017-1445-8
   Sayin SI, 2013, CELL METAB, V17, P225, DOI 10.1016/j.cmet.2013.01.003
   Scarpello JHB, 1998, DIABETIC MED, V15, P651, DOI 10.1002/(SICI)1096-9136(199808)15:8<651::AID-DIA628>3.0.CO;2-A
   Shapiro H, 2018, J EXP MED, V215, P383, DOI 10.1084/jem.20171965
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Soret R, 2010, GASTROENTEROLOGY, V138, P1772, DOI 10.1053/j.gastro.2010.01.053
   Su BL, 2015, J DIABETES, V7, P729, DOI 10.1111/1753-0407.12232
   Sun J, 2016, BRIT J NUTR, V115, P1167, DOI 10.1017/S0007114516000076
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Varyukhina S, 2012, MICROBES INFECT, V14, P273, DOI 10.1016/j.micinf.2011.10.007
   Vijay-Kumar M, 2010, SCIENCE, V328, P228, DOI 10.1126/science.1179721
   Vrieze A, 2012, GASTROENTEROLOGY, V143, P913, DOI 10.1053/j.gastro.2012.06.031
   Wahlstrom A, 2016, CELL METAB, V24, P41, DOI 10.1016/j.cmet.2016.05.005
   Wang HB, 2012, DIGEST DIS SCI, V57, P3126, DOI 10.1007/s10620-012-2259-4
   Wang L, 2016, SCI REP-UK, V6, DOI [10.1038/srep38380, 10.1038/srep33251, 10.1038/srep20004]
   Wrzosek L, 2013, BMC BIOL, V11, DOI 10.1186/1741-7007-11-61
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Wu HJ, 2012, GUT MICROBES, V3, P4, DOI 10.4161/gmic.19320
   Yoon MS, 2016, NUTRIENTS, V8, DOI 10.3390/nu8070405
   Zaneveld JR, 2017, NAT MICROBIOL, V2, DOI 10.1038/nmicrobiol.2017.121
   Zeevi D, 2015, CELL, V163, P1079, DOI 10.1016/j.cell.2015.11.001
   Zhang XY, 2017, DIABETES THER, V8, P293, DOI 10.1007/s13300-017-0226-y
   Zhang XQ, 2015, SCI REP-UK, V5, DOI 10.1038/srep10737
   Zhou ZY, 2016, ACTA PHARMACOL SIN, V37, P1063, DOI 10.1038/aps.2016.21
NR 75
TC 33
Z9 37
U1 6
U2 61
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1499-2671
EI 2352-3840
J9 CAN J DIABETES
JI Can. J. Diabetes
PD APR
PY 2019
VL 43
IS 3
BP 224
EP 231
DI 10.1016/j.jcjd.2019.01.007
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA HQ7SW
UT WOS:000462623200014
PM 30929665
DA 2023-06-08
ER

PT J
AU Yan, X
AF Yan, Xiao
TI Impacts of Metformin on Local Ovarian Cell Tissue of Rats with
   Polycystic Ovary Syndrome and Intestinal Flora Under Aerobic Exercise
SO JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING
LA English
DT Article
DE Polycystic Ovary Syndrome; Aerobic Exercise; Local Cell Tissue;
   Metformin; Intestinal Flora
ID LIFE-STYLE; WOMEN; DISORDERS
AB In order to explore the possible treatment mechanism of metformin on the local ovarian cell tissue of rats with polycystic ovary syndrome (PCOS), 35 female clean sterile rats were selected as the research objects in this study, and randomly divided a PCOS model group (PCOS MG) (25 rats) and a control group (CG) (10 rats). After the modelling was completed, 5 rats were randomly selected to evaluate the modelling effect. When the success rate was higher than 80%, the remaining model rats were divided into two groups randomly, namely the (PCOS MG) (10 rats) and the treatment group (TG) (10 rats). Hematoxylin-eosin (HE) staining was performed on ovarian tissue of the rat, and the ovarian tissue structure was observed under light microscope. Immunohistochemistry was used to detect the distribution and expression levels of tumour necrosis factor-alpha (TNF-alpha), insulin-like growth factor-I (IGF-I), and connective tissue growth factor (CTGF) on the ovaries of rats in each group. It was found by observing the vaginal smear under the microscope that the rats in the (PCOS MG) had lost the regular estrous cycle, suggesting that there was no ovulation. The expression levels of TNF-alpha and CTGF in rats in the (PCOS MG) were greatly higher than those in the CG (P < 0.05); compared with the (PCOS MG), the expression levels of TNF-alpha and CTGF in the TG were decreased observably (P < 0.05). IGF-I was mainly expressed in granulosa cells (GCs) and follicular membrane cells (FMCs) of the ovarian tissue. The expression level of IGF-I in ovarian GCs in rats in the (PCOS MG) was significantly higher than that in the CG (P < 0.05). The expression level of IGF-I in GCs in the TG was lower significantly than that in the (PCOS MG) (P < 0.05). By comparing with rats in the CG, the rats in the (PCOS MG) had obviously decreased Actinobacteria and Betaproteobacteria in the intestinal tract, and the proportion of Firmicutes in the intestine was significantly increased; the amount of butyric acid in the faeces of rats with aerobic exercise was obviously higher than that in the (PCOS MG), because exercise increased the proportion of intestinal butyric acid-producing bacteria. Conclusion: metformin combined with aerobic exercise can treat the PCOS by regulating serum hormone levels and the expression levels of TNF-alpha, IGF-I, and CTGF.
C1 [Yan, Xiao] Shanghai Univ Tradit Chinese Med, Dept Gynaecol & Obstet, Putuo Hosp, Shanghai 200062, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine
RP Yan, X (通讯作者)，Shanghai Univ Tradit Chinese Med, Dept Gynaecol & Obstet, Putuo Hosp, Shanghai 200062, Peoples R China.
CR Arentz S, 2017, PHYTOTHER RES, V31, P1330, DOI 10.1002/ptr.5858
   Banaszewska B, 2016, J CLIN ENDOCR METAB, V101, P4322, DOI 10.1210/jc.2016-1858
   Benham JL, 2018, CLIN OBES, V8, P275, DOI 10.1111/cob.12258
   Blackshaw LCD., 2019, MED SCI BASEL, V7, pE76
   Chen Z. J., NEW ENGL J MED, P375
   Deepika MLN, 2013, J ASSIST REPROD GEN, V30, P1493, DOI 10.1007/s10815-013-0080-4
   Dokras A, 2018, FERTIL STERIL, V109, P888, DOI 10.1016/j.fertnstert.2018.01.038
   Dragamestianos C, 2019, GYNECOL OBSTET INVES, V84, P35, DOI 10.1159/000491086
   Ely BR, 2019, AM J PHYSIOL-ENDOC M, V317, pE172, DOI 10.1152/ajpendo.00549.2018
   Ibanez L, 2019, LANCET DIABETES ENDO, V7, P242, DOI 10.1016/S2213-8587(19)30060-9
   Jedel E, 2011, AM J PHYSIOL-ENDOC M, V300, pE37, DOI 10.1152/ajpendo.00495.2010
   Khatlani K, 2019, METAB SYNDR RELAT D, V17, P473, DOI 10.1089/met.2019.0049
   Kim CH, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-64776-w
   Kite C, 2019, SYST REV-LONDON, V8, DOI 10.1186/s13643-019-0962-3
   Lingaiah S, 2019, FERTIL STERIL, V112, P362, DOI 10.1016/j.fertnstert.2019.04.013
   Noroozzadeh M, 2017, LIFE SCI, V191, P259, DOI 10.1016/j.lfs.2017.10.020
   Oliveira FR, 2019, EUR J ENDOCRINOL, V181, P473, DOI 10.1530/EJE-19-0505
   Pradas I, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-52263-w
   Savastano S, 2010, J ENDOCRINOL INVEST, V33, P446, DOI 10.1007/BF03346622
   Shokrpour M, 2019, GYNECOL ENDOCRINOL, V35, P406, DOI 10.1080/09513590.2018.1540570
   Stepto NK, 2019, SPORTS MED, V49, P1143, DOI 10.1007/s40279-019-01133-6
   Wang QY, 2016, CHINESE MED J-PEKING, V129, P883, DOI 10.4103/0366-6999.179783
   Woodward A, 2020, TRIALS, V21, DOI 10.1186/s13063-019-3962-7
   Woodward A, 2019, SYST REV-LONDON, V8, DOI 10.1186/s13643-019-1030-8
   Zhong ZH, 2018, MOL MED REP, V17, P4889, DOI 10.3892/mmr.2018.8463
NR 25
TC 0
Z9 0
U1 0
U2 12
PU AMER SCIENTIFIC PUBLISHERS
PI VALENCIA
PA 26650 THE OLD RD, STE 208, VALENCIA, CA 91381-0751 USA
SN 2157-9083
EI 2157-9091
J9 J BIOMATER TISS ENG
JI J. Biomater. Tissue Eng.
PD DEC
PY 2021
VL 11
IS 12
BP 2381
EP 2388
DI 10.1166/jbt.2021.2854
PG 8
WC Cell & Tissue Engineering
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA UH1US
UT WOS:000689725600009
DA 2023-06-08
ER

PT J
AU Lovell, H
   Mitchell, A
   Ovadia, C
   Pitrelli, N
   Briley, A
   Singh, C
   Marschall, HU
   Cruickshank, K
   Murphy, H
   Seed, P
   Williamson, C
AF Lovell, Holly
   Mitchell, Alice
   Ovadia, Caroline
   Pitrelli, Noelia
   Briley, Annette
   Singh, Claire
   Marschall, Hanns-Ulrich
   Cruickshank, Kennedy
   Murphy, Helen
   Seed, Paul
   Williamson, Catherine
TI A multi-centered trial investigating gestational treatment with
   ursodeoxycholic acid compared to metformin to reduce effects of diabetes
   mellitus (GUARD): a randomized controlled trial protocol
SO TRIALS
LA English
DT Article
DE Gestational diabetes mellitus; Treatment; Ursodeoxycholic acid;
   Metformin; Randomized clinical trial
ID PULSE-WAVE VELOCITY; GLUCOSE-TOLERANCE; INTRAHEPATIC CHOLESTASIS;
   ADVERSE PREGNANCY; GUT MICROBIOTA; FOLLOW-UP; WOMEN; INSULIN; OUTCOMES;
   RISK
AB Background Each year in the UK, approximately 35,000 women develop gestational diabetes mellitus (GDM). The condition increases the risk of obstetric and neonatal complications for mother and child, including preeclampsia, preterm birth, and large for gestational age babies. Biochemical consequences include maternal hyperglycemia, neonatal hypoglycemia, and dyslipidemia. Metformin is the most commonly used firstline pharmacological treatment. However, there are concerns about its widespread use during pregnancy, due to its limited efficacy and potential safety concerns. Therefore, there is a need for additional therapies that improve both maternal-fetal glucose and lipid metabolism. Ursodeoxycholic acid (UDCA) is not currently used for treatment for GDM. However, it can improve glucose control in type 2 diabetes, and it improves fetal lipid profiles in gestational cholestasis. Consequentially, it is hypothesized that treatment with UDCA for women with GDM may improve both maternal metabolism and neonatal outcomes. The primary outcome of this trial is to assess the efficacy of UDCA compared with metformin to improve glucose levels in women with GDM. Methods The trial is a two-armed, open-label, multi-center, randomized controlled trial. Women are eligible if they have been diagnosed with GDM by an oral glucose tolerance test between 24 + 0 and 30 + 6 weeks' gestation, and if they require pharmacological intervention. In total, 158 pregnant women will be recruited across seven NHS Trusts in England and Wales. Women who consent will be recruited and randomized to either metformin or UDCA, which will be taken daily until the birth of their baby. Maternal and neonatal blood samples will be taken to evaluate the impact of the treatments on maternal glucose control, and maternal and neonatal lipid metabolism. Maternal and fetal outcomes will be evaluated, and acceptability of UDCA compared with metformin will be assessed. Discussion This trial has the potential to identify a potential new treatment for women with GDM. If successful, a future large multi-center trial will be designed to investigate where decisions can be personalized to identify which women will respond more effectively to UDCA than alternatives to improve maternal and baby outcomes.
C1 [Lovell, Holly; Pitrelli, Noelia] Guys & St Thomas NHS Fdn Trust, London, England.
   [Mitchell, Alice; Ovadia, Caroline; Singh, Claire; Cruickshank, Kennedy; Seed, Paul; Williamson, Catherine] Kings Coll London, London, England.
   [Briley, Annette] Flinders Univ South Australia, Caring Futures Inst, Adelaide, SA, Australia.
   [Marschall, Hanns-Ulrich] Univ Gothenburg, Gothenburg, Sweden.
   [Murphy, Helen] Univ East Angela, Cambridge Univ Hosp NHS Fdn Trust, Cambridge, England.
C3 Guy's & St Thomas' NHS Foundation Trust; RLUK- Research Libraries UK;
   University of London; King's College London; Flinders University South
   Australia; University of Gothenburg; RLUK- Research Libraries UK;
   University of Cambridge
RP Williamson, C (通讯作者)，Kings Coll London, London, England.
EM catherine.williamson@kcl.ac.uk
RI Mitchell, Alice/HLQ-0764-2023; Seed, Paul T/C-4435-2008
OI Seed, Paul T/0000-0001-7904-7933; Briley, Annette/0000-0002-4266-920X
FU J.P. Moulton Foundation (REF Tommy's Grant) [81]; NIHR
FX Funding to conduct the trial is provided by J.P. Moulton Foundation (REF
   Tommy's Grant 81) and an NIHR Senior Investigators grant (Professor
   Catherine Williamson).
CR Albareda M, 2003, DIABETES CARE, V26, P1199, DOI 10.2337/diacare.26.4.1199
   Anderson SG, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0103217
   Athukorala C, 2007, AUST NZ J OBSTET GYN, V47, P37, DOI 10.1111/j.1479-828X.2006.00676.x
   Banerjee M, 2012, CLIN SCI, V122, P53, DOI 10.1042/CS20110033
   Barbour LA, 2018, AM J OBSTET GYNECOL, V219, DOI 10.1016/j.ajog.2018.06.013
   Ben-Shlomo Y, 2014, J AM COLL CARDIOL, V63, P636, DOI 10.1016/j.jacc.2013.09.063
   Black MH, 2010, DIABETES CARE, V33, P2524, DOI 10.2337/dc10-1445
   Bradley C, 2002, DIABETES-METAB RES, V18, pS64, DOI 10.1002/dmrr.279
   BRADLEY C, 1994, DIABETIC MED, V11, P510, DOI 10.1111/j.1464-5491.1994.tb00316.x
   Buchholz I, 2018, PHARMACOECONOMICS, V36, P645, DOI 10.1007/s40273-018-0642-5
   Chappell LC, 2019, LANCET, V394, P849, DOI 10.1016/S0140-6736(19)31270-X
   Collado MC, 2008, AM J CLIN NUTR, V88, P894, DOI 10.1093/ajcn/88.4.894
   Cruickshank K, 2002, CIRCULATION, V106, P2085, DOI 10.1161/01.CIR.0000033824.02722.F7
   Crusell MKW, 2018, MICROBIOME, V6, DOI 10.1186/s40168-018-0472-x
   Danne T, 2017, DIABETES CARE, V40, P1631, DOI 10.2337/dc17-1600
   Fasshauer M, 2014, LANCET DIABETES ENDO, V2, P488, DOI 10.1016/S2213-8587(13)70176-1
   FDA,, 2021, FDA AUTH 1 FULL INT
   Flynn AC, 2016, INT J BEHAV NUTR PHY, V13, DOI 10.1186/s12966-016-0450-2
   Foghsgaard S, 2017, DIABETES CARE, V40, P109, DOI 10.2337/dc16-1017
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Gao ZG, 2009, DIABETES, V58, P1509, DOI 10.2337/db08-1637
   Gardosi J, 2018, AM J OBSTET GYNECOL, V218, pS609, DOI 10.1016/j.ajog.2017.12.011
   GELLER NL, 1987, BIOMETRICS, V43, P213, DOI 10.2307/2531962
   Hanem LGE, 2018, J CLIN ENDOCR METAB, V103, P1612, DOI 10.1210/jc.2017-02419
   Harmon KA, 2011, DIABETES CARE, V34, P2198, DOI 10.2337/dc11-0723
   Kawasaki M, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0190676
   Koren O, 2012, CELL, V150, P470, DOI 10.1016/j.cell.2012.07.008
   KREYMANN B, 1987, LANCET, V2, P1300
   Langer O, 2000, NEW ENGL J MED, V343, P1134, DOI 10.1056/NEJM200010193431601
   Leybovitz-Haleluya N, 2018, ACTA DIABETOL, V55, P1037, DOI 10.1007/s00592-018-1176-1
   Lowe WL, 2018, JAMA-J AM MED ASSOC, V320, P1005, DOI 10.1001/jama.2018.11628
   Manna LB, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-67301-1
   Martineau MG, 2015, DIABETES CARE, V38, P243, DOI 10.2337/dc14-2143
   Martis R, 2018, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD012327.pub2
   Mendez-Sanchez Nahum, 2004, Ann Hepatol, V3, P108
   Metzger BE, 2008, NEW ENGL J MED, V358, P1991, DOI 10.1056/NEJMoa0707943
   Murphy HR, 2007, DIABETES CARE, V30, P2785, DOI 10.2337/dc07-0500
   National Institute for Health and Care Excellence, 2020, DIAB PREGN MAN PREC
   O'Sullivan EP, 2011, DIABETOLOGIA, V54, P1670, DOI 10.1007/s00125-011-2150-4
   Ovadia C, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-60821-w
   Panagiotopoulou O, 2020, AM J OBSTET GYNECOL, V223, DOI 10.1016/j.ajog.2020.01.054
   Reynolds RM, 2017, BMC PREGNANCY CHILDB, V17, DOI 10.1186/s12884-017-1505-3
   Romero R, 2017, AM J OBSTET GYNECOL, V217, P282, DOI 10.1016/j.ajog.2017.06.003
   Rowan JA, 2008, NEW ENGL J MED, V358, P2003, DOI 10.1056/NEJMoa0707193
   Rowan JA, 2011, DIABETES CARE, V34, P2279, DOI 10.2337/dc11-0660
   Ryckman KK, 2015, BJOG-INT J OBSTET GY, V122, P643, DOI 10.1111/1471-0528.13261
   Sacco F, 2016, BRIT J CANCER, V115, P1451, DOI 10.1038/bjc.2016.385
   Sanchez-Garcia A, 2018, PHARMACOL RES, V135, P144, DOI 10.1016/j.phrs.2018.08.008
   Schaefer-Graf UM, 2008, DIABETES CARE, V31, P1858, DOI 10.2337/dc08-0039
   Shemer EW, 2013, BJOG-INT J OBSTET GY, V120, P717, DOI 10.1111/1471-0528.12174
   Shima KR, 2018, BMJ OPEN DIAB RES CA, V6, DOI 10.1136/bmjdrc-2017-000469
   Son GH, 2010, ACTA OBSTET GYN SCAN, V89, P700, DOI 10.3109/00016341003605677
   Tobias DK, 2017, JAMA INTERN MED, V177, P1735, DOI 10.1001/jamainternmed.2017.2790
   van Weelden W, 2018, DIABETES THER, V9, P1811, DOI 10.1007/s13300-018-0479-0
   Vanky E, 2010, J CLIN ENDOCR METAB, V95, pE448, DOI 10.1210/jc.2010-0853
   Vlachopoulos C, 2010, EUR HEART J, V31, P1865, DOI 10.1093/eurheartj/ehq024
   Webster LM, 2019, ULTRASOUND OBST GYN, V53, P638, DOI 10.1002/uog.19021
   White IR, 2011, BMJ-BRIT MED J, V342, DOI 10.1136/bmj.d40
   White SL, 2017, DIABETOLOGIA, V60, P1903, DOI 10.1007/s00125-017-4380-6
NR 59
TC 0
Z9 0
U1 2
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1745-6215
J9 TRIALS
JI Trials
PD JUL 19
PY 2022
VL 23
IS 1
AR 571
DI 10.1186/s13063-022-06462-y
PG 21
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 3B2BC
UT WOS:000827750400006
PM 35854327
OA Green Published, Green Submitted, gold
DA 2023-06-08
ER

PT J
AU Parrott, JL
   Restivo, VE
   Kidd, KA
   Zhu, J
   Shires, K
   Clarence, S
   Khan, H
   Sullivan, C
   Pacepavicius, G
   Alaee, M
AF Parrott, Joanne L.
   Restivo, Victoria E.
   Kidd, Karen A.
   Zhu, Juliet
   Shires, Kallie
   Clarence, Stacey
   Khan, Hufsa
   Sullivan, Cheryl
   Pacepavicius, Grazina
   Alaee, Mehran
TI Chronic Embryo-Larval Exposure of Fathead Minnows to the Pharmaceutical
   Drug Metformin: Survival, Growth, and Microbiome Responses
SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
LA English
DT Article
DE Pharmaceuticals; Municipal effluents; Aquatic toxicology; Microbiome;
   Fathead minnow; Growth
ID GUT MICROBIOME; PROTEOBACTERIA; CHEMICALS; TOXICITY; HEALTH
AB Metformin is a glucose-lowering drug commonly found in municipal wastewater effluents (MWWEs). The present study investigated the chronic effects of metformin in early-life stages of the fathead minnow (Pimephales promelas). Endpoints assessed were growth, survival, and deformities. The larval gut microbiome was also examined using 16 S ribosomal RNA gene amplicon sequencing to determine microbial community composition and alpha and beta diversity. Eggs and larvae were exposed to metformin measured concentrations (mean [standard deviation]) of 0.020 (0.017) mu g/L (for controls) and 3.44 (0.23), 33.6 (1.6), and 269 (11) mu g/L in a daily static-renewal setup, with 20 embryos per beaker. The low and middle metformin exposure concentrations represent river and MWWE concentrations of metformin. To detect small changes in growth, we used 18 replicate beakers for controls and 9 replicates for each metformin treatment. Over the 21-d exposure (5 d as embryos and 16 d posthatch [dph]), metformin did not affect survival or growth of larval fish. Hatch success, time to hatch, deformities in hatched fry, and survival were similar across all treatments. Growth (wet wt, length, and condition factor) assessed at 9 and 16 dph was also unaffected by metformin. Assessment of the microbiome showed that the larvae microbiome was dominant in Proteobacteria and Firmicutes, with small increases in Proteobacteria and decreases in Firmicutes with increasing exposure to metformin. No treatment effects were found for microbiome diversity measures. Control fish euthanized with the anesthetic tricaine methane sulfonate had decreased alpha diversity compared to those sampled by spinal severance. This experiment demonstrates that metformin at environmentally relevant concentrations (3.44 and 33.6 mu g/L) and at 10 times MWWE concentrations (269 mu g/L) does not adversely affect larval growth or gut microbiome in this ubiquitous freshwater fish species. Environ Toxicol Chem 2021;00:1-13. (c) 2021 SETAC (c) 2021 SETAC
C1 [Parrott, Joanne L.; Shires, Kallie; Clarence, Stacey; Khan, Hufsa; Sullivan, Cheryl; Pacepavicius, Grazina; Alaee, Mehran] Environm & Climate Change Canada, Water Sci & Technol Directorate, Burlington, ON, Canada.
   [Restivo, Victoria E.; Kidd, Karen A.; Zhu, Juliet] McMaster Univ, Dept Biol, Hamilton, ON, Canada.
   [Kidd, Karen A.] McMaster Univ, Sch Earth Environm & Soc, Hamilton, ON, Canada.
C3 Environment & Climate Change Canada; McMaster University; McMaster
   University
RP Parrott, JL (通讯作者)，Environm & Climate Change Canada, Water Sci & Technol Directorate, Burlington, ON, Canada.
EM joanne.parrott@canada.ca
RI Kidd, Karen/ABG-3237-2020; Sullivan, Cheryl Suzette/HNC-2608-2023
OI Kidd, Karen/0000-0002-5619-1358; 
FU Chemicals Management Plan of Health Canada; National Science and
   Engineering Council of Canada [312237-2012]; Jarislowsky Foundation
FX The Chemicals Management Plan of Health Canada funded the initial study.
   The present study was supported by a National Science and Engineering
   Council of Canada Discovery Grant (312237-2012 to K.A. Kidd) and the
   Jarislowsky Foundation (to K.A. Kidd). We are grateful to the Aquatic
   Life Research Facility manager A. Mehlenbacher for use of the exposure
   laboratory and to M. Gardiner for assistance with the fish exposures.
   Thank you to M. Surette, M. Shah, and L. Rossi (Farncombe Institute,
   McMaster University) for their technical and microbial expertise. We are
   grateful to Health Canada/Environment and Climate Change Canada for
   review of the manuscript.
CR Elizalde-Velazquez GA, 2020, SCI TOTAL ENVIRON, V702, DOI 10.1016/j.scitotenv.2019.134924
   Bradley PM, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0228214
   Bridges KN, 2018, ENVIRON SCI TECHNOL, V52, P8774, DOI 10.1021/acs.est.8b01150
   Bryrup T, 2019, DIABETOLOGIA, V62, P1024, DOI 10.1007/s00125-019-4848-7
   Cheesman SE, 2011, P NATL ACAD SCI USA, V108, P4570, DOI 10.1073/pnas.1000072107
   Dahan D, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.01323
   Davidson MB, 1997, AM J MED, V102, P99, DOI 10.1016/S0002-9343(96)00353-1
   DeBofsky A, 2020, CHEMOSPHERE, V252, DOI 10.1016/j.chemosphere.2020.126461
   Eichmiller JJ, 2016, MICROBIOME, V4, DOI 10.1186/s40168-016-0190-1
   Elbere I, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0204317
   Elliott SM, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0182868
   Elliott SM, 2017, SCI TOTAL ENVIRON, V579, P1726, DOI 10.1016/j.scitotenv.2016.11.114
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   HOLCOMBE GW, 1995, ARCH ENVIRON CON TOX, V28, P287, DOI 10.1007/BF00213104
   Hutchinson TH, 1998, CHEMOSPHERE, V36, P129, DOI 10.1016/S0045-6535(97)10025-X
   Jacob S, 2018, ENVIRON SCI EUR, V30, DOI 10.1186/s12302-018-0179-4
   LaLone CA, 2013, ENVIRON TOXICOL CHEM, V32, P2528, DOI 10.1002/etc.2330
   Lee JW, 2019, J HAZARD MATER, V367, P171, DOI 10.1016/j.jhazmat.2018.12.084
   Li XH, 2017, MICROB ECOL, V74, P239, DOI 10.1007/s00248-016-0924-4
   MCKIM JM, 1977, J FISH RES BOARD CAN, V34, P1148, DOI 10.1139/f77-172
   Meador JP, 2016, ENVIRON POLLUT, V213, P254, DOI 10.1016/j.envpol.2016.01.088
   Milligan-Myhre, 2017, J BACTERIOL, V199, P1
   Napolitano A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100778
   Narrowe AB, 2015, MICROBIOME, V3, DOI 10.1186/s40168-015-0069-6
   Niemuth NJ, 2015, CHEMOSPHERE, V135, P38, DOI 10.1016/j.chemosphere.2015.03.060
   Oliveira TS, 2015, SCI TOTAL ENVIRON, V518, P459, DOI 10.1016/j.scitotenv.2015.02.104
   Mendez-Salazar EO, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.02494
   Domecq JP, 2015, J CLIN ENDOCR METAB, V100, P363, DOI 10.1210/jc.2014-3421
   Parrott JL, 2016, ENVIRON POLLUT, V210, P40, DOI 10.1016/j.envpol.2015.11.037
   Giang PT, 2018, SCI TOTAL ENVIRON, V625, P1494, DOI 10.1016/j.scitotenv.2018.01.020
   R Core Team, 2022, R LANG ENV STAT COMP
   Reis PJM, 2018, J HAZARD MATER, V358, P310, DOI 10.1016/j.jhazmat.2018.07.012
   Restivo VE, 2021, SCI TOTAL ENVIRON, V751, DOI 10.1016/j.scitotenv.2020.141724
   Rogall ET, 2020, ENVIRON SCI EUR, V32, DOI 10.1186/s12302-020-00341-6
   Sakalli S, 2018, SCI TOTAL ENVIRON, V635, P1160, DOI 10.1016/j.scitotenv.2018.04.188
   Shin NR, 2015, TRENDS BIOTECHNOL, V33, P496, DOI 10.1016/j.tibtech.2015.06.011
   Stroup TS, 2018, WORLD PSYCHIATRY, V17, P341, DOI 10.1002/wps.20567
   Tarnecki AM, 2017, J APPL MICROBIOL, V123, P2, DOI 10.1111/jam.13415
   Tiwari N, 2019, EUR J OBSTET GYN R B, V234, P149, DOI 10.1016/j.ejogrb.2018.12.021
   Trautwein C, 2014, ENVIRON INT, V70, P203, DOI 10.1016/j.envint.2014.05.008
   Trautwein C, 2011, CHEMOSPHERE, V85, P765, DOI 10.1016/j.chemosphere.2011.06.057
   Turner LA, 2019, J EXP BIOL, V222, DOI 10.1242/jeb.209882
   Ussery E, 2018, AQUAT TOXICOL, V205, P58, DOI 10.1016/j.aquatox.2018.10.003
   Vila AV, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-019-14177-z
   Wang FF, 2018, OBES REV, V19, P1424, DOI 10.1111/obr.12720
   Weersma RK, 2020, GUT, V69, P1510, DOI 10.1136/gutjnl-2019-320204
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Yan QY, 2016, ENVIRON MICROBIOL, V18, P4739, DOI 10.1111/1462-2920.13365
NR 48
TC 6
Z9 6
U1 2
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0730-7268
EI 1552-8618
J9 ENVIRON TOXICOL CHEM
JI Environ. Toxicol. Chem.
PD MAR
PY 2022
VL 41
IS 3
BP 635
EP 647
DI 10.1002/etc.5054
EA JUN 2021
PG 13
WC Environmental Sciences; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Toxicology
GA ZH4WM
UT WOS:000656812000001
PM 33788292
OA Green Published
DA 2023-06-08
ER

PT J
AU Allin, KH
   Jensen, CB
   Jacobsen, RK
   Jess, T
AF Allin, Kristine H.
   Jensen, Camilla B.
   Jacobsen, Rikke K.
   Jess, Tine
TI Metformin use is not associated with reduced risk of older onset
   inflammatory bowel disease: a Danish nationwide population-based study
SO JOURNAL OF GASTROENTEROLOGY
LA English
DT Article
DE Biguanides; Colitis; Ulcerative; Crohn Disease; Pharmacoepidemiology
ID SUPPRESSES; MICROBIOTA
AB Background Metformin has pleiotropic effects including anti-inflammatory properties and effects on the gut microbiome. It is primarily used in the older population, where the occurrence of inflammatory bowel disease (IBD) is increasing. The aim of this study was to examine whether metformin protects against development of IBD. Methods In the setting of a Danish nationwide population-based cohort, we conducted a nested case-control study using a new-user active comparator design. For each patient with IBD, we selected 10 IBD-free individuals matched on age, sex, and duration of follow-up. Conditional logistic regression was used to estimate odds ratios (ORs) of IBD. Adjustment included educational level, other immune-mediated inflammatory diseases, and use of dipeptidyl peptidase (DPP)-4 inhibitors and statins. Results Among 302,863 IBD-free new users of oral glucose-lowering drugs, we identified 1271 patients who developed IBD and 12,676 matched IBD-free individuals. Mean age at IBD diagnosis was 66 (SD, 11) years. We found no association between ever use of metformin and risk of IBD, Crohn's disease or ulcerative colitis, adjusted OR 0.95 (95% CI 0.78-1.15), 0.87 (95% CI 0.60-1.26), and 1.04 (95% CI 0.83-1.31), respectively. Neither was the cumulative dose of metformin or the treatment duration with metformin associated with risk of IBD. Conclusions In this population-based study, we report that despite anti-inflammatory effects and a notable impact on the gut microbiome, metformin use is not associated with reduced risk of older onset IBD.
C1 [Allin, Kristine H.; Jess, Tine] Aalborg Univ, Ctr Mol Predict Inflammatory Bowel Dis PREDICT, Dept Clin Med, AC Meyers Vaenge 15, DK-2450 Copenhagen, Denmark.
   [Allin, Kristine H.; Jess, Tine] Aalborg Univ Hosp, Dept Gastroenterol & Hepatol, Aalborg, Denmark.
   [Jensen, Camilla B.; Jacobsen, Rikke K.] Capital Reg, Ctr Clin Res & Prevent, Bispebjerg & Frederiksberg Hosp, Copenhagen, Denmark.
C3 Aalborg University; Aalborg University; Aalborg University Hospital;
   University of Copenhagen; Bispebjerg Hospital
RP Allin, KH (通讯作者)，Aalborg Univ, Ctr Mol Predict Inflammatory Bowel Dis PREDICT, Dept Clin Med, AC Meyers Vaenge 15, DK-2450 Copenhagen, Denmark.; Allin, KH (通讯作者)，Aalborg Univ Hosp, Dept Gastroenterol & Hepatol, Aalborg, Denmark.
EM allin@dcm.aau.dk
OI Allin, Kristine Hojgaard/0000-0002-6880-5759
FU Novo Nordisk Foundation [NNF16OC0022586]; Danish National Research
   Foundation [DNRF148]
FX This work was supported by The Novo Nordisk Foundation [grant number
   NNF16OC0022586] and The Danish National Research Foundation [Grant no.
   DNRF148]. These had no role in the study design or in the collection,
   analysis, and interpretation of data.
CR Arai M, 2010, J PHARMACOL EXP THER, V334, P206, DOI 10.1124/jpet.109.164970
   Bailey CJ, 2008, DIABETOLOGIA, V51, P1552, DOI 10.1007/s00125-008-1053-5
   Bryrup T, 2019, DIABETOLOGIA, V62, P1024, DOI 10.1007/s00125-019-4848-7
   Cardel M, 2014, CANCER MED-US, V3, P1458, DOI 10.1002/cam4.306
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   de Souza HSP, 2017, NAT REV GASTRO HEPAT, V14, P739, DOI 10.1038/nrgastro.2017.110
   Farmer RE, 2017, INT J EPIDEMIOL, V46, P728, DOI 10.1093/ije/dyw275
   Fonager K, 1996, SCAND J GASTROENTERO, V31, P154, DOI 10.3109/00365529609031980
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Jensen VM, 2011, SCAND J PUBLIC HEALT, V39, P91, DOI 10.1177/1403494810394715
   Kildemoes HW, 2011, SCAND J PUBLIC HEALT, V39, P38, DOI 10.1177/1403494810394717
   Kim J, 2014, J BIOL CHEM, V289, P23246, DOI 10.1074/jbc.M114.577908
   Lo B, 2020, SCAND J GASTROENTERO, V55, P1171, DOI 10.1080/00365521.2020.1807598
   Lynge E, 2011, SCAND J PUBLIC HEALT, V39, P30, DOI 10.1177/1403494811401482
   Ng SC, 2017, LANCET, V390, P2769, DOI 10.1016/S0140-6736(17)32448-0
   Olen O, 2020, GUT, V69, P453, DOI 10.1136/gutjnl-2018-317572
   Pittayanon R, 2020, GASTROENTEROLOGY, V158, P930, DOI 10.1053/j.gastro.2019.11.294
   Schirmer M, 2019, NAT REV MICROBIOL, V17, P497, DOI 10.1038/s41579-019-0213-6
   Schmidt M, 2014, EUR J EPIDEMIOL, V29, P541, DOI 10.1007/s10654-014-9930-3
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Suissa S, 2008, AM J EPIDEMIOL, V167, P492, DOI 10.1093/aje/kwm324
   Suissa S, 2012, DIABETES CARE, V35, P2665, DOI 10.2337/dc12-0788
   Torres J, 2017, LANCET, V389, P1741, DOI 10.1016/S0140-6736(16)31711-1
   Tseng CH, 2021, J CROHNS COLITIS, V15, P64, DOI 10.1093/ecco-jcc/jjaa136
   Ungaro R, 2017, LANCET, V389, P1756, DOI 10.1016/S0140-6736(16)32126-2
   Vasamsetti SB, 2015, DIABETES, V64, P2028, DOI 10.2337/db14-1225
   Wang LJ, 2020, GUT, V69, P1988, DOI 10.1136/gutjnl-2019-320105
   Wang YB, 2021, PHARMACOL RES, V165, DOI 10.1016/j.phrs.2021.105425
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
NR 29
TC 1
Z9 1
U1 3
U2 3
PU SPRINGER JAPAN KK
PI TOKYO
PA SHIROYAMA TRUST TOWER 5F, 4-3-1 TORANOMON, MINATO-KU, TOKYO, 105-6005,
   JAPAN
SN 0944-1174
EI 1435-5922
J9 J GASTROENTEROL
JI J. Gastroenterol.
PD OCT
PY 2022
VL 57
IS 10
BP 761
EP 769
DI 10.1007/s00535-022-01896-2
EA JUL 2022
PG 9
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 4Z0XQ
UT WOS:000819879300001
PM 35780256
DA 2023-06-08
ER

PT J
AU Manaer, T
   Yu, L
   Nabi, XH
   Dilidaxi, D
   Liu, L
   Sailike, J
AF Manaer, Tabusi
   Yu, Lan
   Nabi, Xin-Hua
   Dilidaxi, Dinareer
   Liu, Lu
   Sailike, Jialehasibieke
TI The beneficial effects of the composite probiotics from camel milk on
   glucose and lipid metabolism, liver and renal function and gut
   microbiota in db/db mice
SO BMC COMPLEMENTARY MEDICINE AND THERAPIES
LA English
DT Article
DE Composite probiotics camel milk; db; db mice; Gut microbiota; TFCW; TG
ID FERMENTED CHEESE WHEY; LACTOBACILLUS-CASEI; RISK-FACTORS; OBESITY;
   UYGUR; PREVALENCE; MICROFLORA; KAZAKH; HAN
AB Background Probiotics may have beneficial effects on patients with type 2 diabetes mellitus (T2DM). We separated 4 lactobacillus and 1 saccharomycetes from traditional fermented cheese whey (TFCW) and prepared composite probiotics from camel milk (CPCM) and investigated their effects on glucose and lipid metabolism, liver and renal function and gut microbiota in db/db mice. Methods CPCM was prepared in the laboratory and 40 db/db mice were randomly divided into 4 groups as metformin, low-dose and high-dose group and model group, and treated for 6 weeks. In addition, 10 C57BL/Ks mice as normal control group were used for comparison. Fasting blood glucose (FBG), body weight (BW), oral glucose tolerance test (OGTT), glycated hemoglobin (HbAlc), C-peptide (CP), triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), 24 h urinary microalbumin (24 h malb), urine ketone, urine sugar, pancreas and liver tissue and intestinal flora were tested. Results Compared to diabetic group, high dose CPCM significantly decreased FBG, OGTT, HbAlc and IRI, plasma TC, TG, LDL-C, 24 h malb, urine ketone and urine sugar, increased CP, HDL-C levels, improved the liver and kidney function, protected the function of islets, also increased intestinal tract lactic acid bacteria and Bifidobacterium, decreased Escherichia in db/db mice. Conclusion CPCM decreased FBG, OGTT and HbAlc, increased CP, modulated lipid metabolism and improved liver and kidney protected injury in db/db mice, which may be related to various probiotics acting through protecting the function of islets and regulating intestinal flora disturbance.
C1 [Manaer, Tabusi; Yu, Lan; Nabi, Xin-Hua; Dilidaxi, Dinareer; Liu, Lu; Sailike, Jialehasibieke] Xinjiang Med Univ, Coll Pharmaceut Sci, Urumqi 830011, Peoples R China.
   [Manaer, Tabusi] Xinjiang Uygur Autonomous Reg Inst Drug Control, Urumqi 830054, Peoples R China.
   [Yu, Lan] Xinjiang Med Univ, Affiliated Hosp 1, Urumqi 830011, Peoples R China.
C3 Xinjiang Medical University; Xinjiang Medical University
RP Nabi, XH (通讯作者)，Xinjiang Med Univ, Coll Pharmaceut Sci, Urumqi 830011, Peoples R China.
EM xinhuanabi@126.com
OI xinhua, nabi/0000-0001-9191-6839
FU Key Laboratory of Active Components of Xinjiang Natural Medicine and
   Drug Release Technology [XJDX1713]; National Natural Science Foundation
   of China [81160344]
FX This research was funded by Key Laboratory of Active Components of
   Xinjiang Natural Medicine and Drug Release Technology (No. XJDX1713) and
   National Natural Science Foundation of China (No. 81160344). The funder
   had no role in the design of the study and collection, analysis, and
   interpretation of data, and in writing of the manuscript.
CR Allen Terri J, 2004, Curr Diab Rep, V4, P435, DOI 10.1007/s11892-004-0053-1
   Amar J, 2011, DIABETOLOGIA, V54, P3055, DOI 10.1007/s00125-011-2329-8
   Tonucci L, 2017, CRIT REV FOOD SCI, V57, P2296, DOI 10.1080/10408398.2014.934438
   Candela M, 2016, BRIT J NUTR, V116, P80, DOI 10.1017/S0007114516001045
   Chen F, 2016, J ETHNOPHARMACOL, V179, P253, DOI 10.1016/j.jep.2015.12.031
   [陈文祥 Chen Wenxiang], 2011, [中国糖尿病杂志, Chinese Journal of Diabetes], V19, P803
   Dinareer Dilidaxi, 2018, Zhongguo Weishengtaxixue Zazhi / Chinese Journal of Microecology, V30, P5
   Ebrahimi ZS, 2017, J DIABETES METAB DIS, V16, DOI 10.1186/s40200-017-0304-8
   Everard A, 2014, MBIO, V5, DOI 10.1128/mBio.01011-14
   Falcinelli S, 2015, SCI REP-UK, V5, DOI 10.1038/srep09336
   Gomes AC, 2014, NUTR J, V13, DOI 10.1186/1475-2891-13-60
   Griffiths EA, 2004, DIGEST DIS SCI, V49, P579, DOI 10.1023/B:DDAS.0000026302.92898.ae
   Hendijani F, 2018, CLIN NUTR, V37, P532, DOI 10.1016/j.clnu.2017.02.015
   Herring R, 2014, DIABETES OBES METAB, V16, P1, DOI 10.1111/dom.12117
   Jia W, 2008, NAT REV DRUG DISCOV, V7, P123, DOI 10.1038/nrd2505
   Lakerveld Jeroen, 2008, BMC Endocr Disord, V8, P6, DOI 10.1186/1472-6823-8-6
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Latipa A., 2014, XINJIANG YIKE DAXUE, V37, P155, DOI [10.3969/j.issn.1009-5551.2014.02.007, DOI 10.3969/J.ISSN.1009-5551.2014.02.007]
   Li NF, 2012, BMC PUBLIC HEALTH, V12, DOI 10.1186/1471-2458-12-499
   Liu AiGuo, 2008, Journal of Northwest A & F University - Natural Science Edition, V36, P203
   Liu SM, 2013, CHIN J FOOD NUTR, V4, P60
   Manaer T, 2015, J ETHNOPHARMACOL, V169, P269, DOI 10.1016/j.jep.2015.04.032
   Mekkes MC, 2014, BENEF MICROBES, V5, P19, DOI 10.3920/BM2012.0069
   Musso G, 2010, DIABETES CARE, V33, P2277, DOI 10.2337/dc10-0556
   Nabi XH, 2016, BMC COMPLEM ALTERN M, V16, DOI 10.1186/s12906-016-1285-8
   [新华·那比 NABI Xinhua], 2007, [中国新药杂志, Chinese Journal New Drugs], V16, P1776
   Nagata S, 2011, BRIT J NUTR, V106, P549, DOI 10.1017/S000711451100064X
   Nova E, 2016, NUTR CLIN PRACT, V31, P387, DOI 10.1177/0884533615620350
   Payne AN, 2011, NUTR DIABETES, V1, DOI 10.1038/nutd.2011.8
   Sailike J., 2019, Zhongguo Weishengtaxixue Zazhi / Chinese Journal of Microecology, V31, P502
   Sartang MM, 2015, J DIABETES RES, V2015, DOI 10.1155/2015/696372
   Singh S, 2017, BENEF MICROBES, V8, P243, DOI 10.3920/BM2016.0090
   Tanaka J, 2005, J MED MICROBIOL, V54, P309, DOI 10.1099/jmm.0.45814-0
   Teng Y, 2018, NUTRIENTS, V10, DOI 10.3390/nu10010075
   Tesch GH, 2011, AM J PHYSIOL-RENAL, V300, pF301, DOI 10.1152/ajprenal.00607.2010
   Le TKC, 2015, BIOMED RES-TOKYO, V36, P63, DOI 10.2220/biomedres.36.63
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Wang J, 2005, FOOD FERMENT SICHUAN, V41, P43
   Wang JM, 2005, J U SCI TECHNOL TIAN, V20, P9
   Wang LF, 2010, J CLIN HYPERTENS, V12, P741, DOI 10.1111/j.1751-7176.2010.00349.x
   [王淼 WANG Miao], 2007, [工业微生物, Industrial Microbiology], V37, P36
   Wang YM, 2020, BIOMED PHARMACOTHER, V125, DOI 10.1016/j.biopha.2020.109914
   Wang ZeJu, 2008, Journal of Huazhong Agricultural University, V27, P664
   Wang ZT, 2004, WORLD J GASTROENTERO, V10, P1619, DOI 10.3748/wjg.v10.i11.1619
   Xu Y, 2013, JAMA-J AM MED ASSOC, V310, P948, DOI 10.1001/jama.2013.168118
   Yadav H, 2007, NUTRITION, V23, P62, DOI 10.1016/j.nut.2006.09.002
   Yan WL, 2015, ETHNIC HEALTH, V20, P365, DOI 10.1080/13557858.2014.921894
   Yan WL, 2005, DIABETES CARE, V28, P2554, DOI 10.2337/diacare.28.10.2554
   Yoo JY, 2016, NUTRIENTS, V8, DOI 10.3390/nu8030173
   Zhang Hong-wu, 2013, Zhonghua Liu Xing Bing Xue Za Zhi, V34, P958
   Zhang X, 2012, PLOS ONE, V7, DOI [10.1371/journal.pone.0042529, 10.1371/journal.pone.0035700]
   Zhou J, 2009, INT J DERMATOL VENER, V35, P222
   薄虹, 2011, [中华肾脏病杂志, Chinese Journal of Nephrology], V27, P464
   肖力, 2010, [中华肾脏病杂志, Chinese Journal of Nephrology], V26, P478
NR 54
TC 8
Z9 9
U1 6
U2 41
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 2662-7671
J9 BMC COMPLEMENT MED
JI BMC Complement. Med. Ther.
PD APR 22
PY 2021
VL 21
IS 1
AR 127
DI 10.1186/s12906-021-03303-4
PG 13
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA RS9EK
UT WOS:000644073900001
PM 33888105
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Zhang, X
   Zhao, YF
   Xu, J
   Xue, ZS
   Zhang, MH
   Pang, XY
   Zhang, XJ
   Zhao, LP
AF Zhang, Xu
   Zhao, Yufeng
   Xu, Jia
   Xue, Zhengsheng
   Zhang, Menghui
   Pang, Xiaoyan
   Zhang, Xiaojun
   Zhao, Liping
TI Modulation of gut microbiota by berberine and metformin during the
   treatment of high-fat diet-induced obesity in rats
SO SCIENTIFIC REPORTS
LA English
DT Article
ID ACTIVATED PROTEIN-KINASE; 16S RIBOSOMAL-RNA; CARDIOVASCULAR-DISEASE;
   METABOLIC SYNDROME; RISK-FACTORS; WEIGHT-LOSS; MICE; PHARMACOKINETICS;
   CHROMATOGRAPHY; INFLAMMATION
AB Accumulating evidence suggests that the gut microbiota is an important factor in mediating the development of obesity-related metabolic disorders, including type 2 diabetes. Metformin and berberine, two clinically effective drugs for treating diabetes, have recently been shown to exert their actions through modulating the gut microbiota. In this study, we demonstrated that metformin and berberine similarly shifted the overall structure of the gut microbiota in rats. Both drugs showed reverting effects on the high-fat diet-induced structural changes of gut microbiota. The diversity of gut microbiota was significantly reduced by both berberine-and metformin-treatments. Nearest shrunken centroids analysis identified 134 operational taxonomic units (OTUs) responding to the treatments, which showed close associations with the changes of obese phenotypes. Sixty out of the 134 OTUs were decreased by both drugs, while those belonging to putative short-chain fatty acids (SCFA)-producing bacteria, including Allobaculum, Bacteriodes, Blautia, Butyricoccus, and Phascolarctobacterium, were markedly increased by both berberine and, to a lesser extent, metformin. Taken together, our findings suggest that berberine and metformin showed similarity in modulating the gut microbiota, including the enrichment of SCFA-producing bacteria and reduction of microbial diversity, which may contribute to their beneficial effects to the host.
C1 [Zhang, Xu; Xu, Jia; Xue, Zhengsheng; Zhang, Menghui; Pang, Xiaoyan; Zhang, Xiaojun; Zhao, Liping] Shanghai Jiao Tong Univ, State Key Lab Microbial Metab, Shanghai 200240, Peoples R China.
   [Zhang, Xu; Xu, Jia; Xue, Zhengsheng; Zhang, Menghui; Pang, Xiaoyan; Zhang, Xiaojun; Zhao, Liping] Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, Shanghai 200240, Peoples R China.
   [Zhao, Yufeng; Zhao, Liping] Shanghai Jiao Tong Univ, Shanghai Ctr Syst Biomed, Shanghai 200240, Peoples R China.
C3 Shanghai Jiao Tong University; Shanghai Jiao Tong University; Shanghai
   Jiao Tong University
RP Zhao, LP (通讯作者)，Shanghai Jiao Tong Univ, State Key Lab Microbial Metab, Shanghai 200240, Peoples R China.
EM lpzhao@sjtu.edu.cn
RI Xu, Jia/GSD-6115-2022; Zhang, Xiaojun/E-9521-2016; zhang,
   menghui/Q-3752-2016
OI Xu, Jia/0000-0002-3341-7668; Zhang, Xiaojun/0000-0002-4559-0177; Zhang,
   Xu/0000-0003-2406-9478
FU National Natural Science Foundation of China (NSFC) [81273720,
   31121064]; key project of NSFC [31330005, 30730005]; National Science
   and Technology Major Project of China [2012ZX10005001-009]
FX This study was supported by the National Natural Science Foundation of
   China (NSFC) (No. 81273720 and No. 31121064), the key project of NSFC
   (No. 31330005 and No. 30730005), and the National Science and Technology
   Major Project of China (2012ZX10005001-009). The funders had no role in
   study design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
CR Backhed F, 2004, P NATL ACAD SCI USA, V101, P15718, DOI 10.1073/pnas.0407076101
   Bajzer M, 2006, NATURE, V444, P1009, DOI 10.1038/4441009a
   Biagi E, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0010667
   Cabreiro F, 2013, CELL, V153, P228, DOI 10.1016/j.cell.2013.02.035
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Caporaso JG, 2010, NAT METHODS, V7, P335, DOI 10.1038/nmeth.f.303
   Choi YH, 2006, J PHARM SCI-US, V95, P2543, DOI 10.1002/jps.20744
   De Filippo C, 2010, P NATL ACAD SCI USA, V107, P14691, DOI 10.1073/pnas.1005963107
   Delzenne NM, 2011, NAT REV ENDOCRINOL, V7, P639, DOI 10.1038/nrendo.2011.126
   Derosa G, 2012, EXPERT OPIN BIOL TH, V12, P1113, DOI 10.1517/14712598.2012.704014
   DeSantis TZ, 2006, NUCLEIC ACIDS RES, V34, pW394, DOI 10.1093/nar/gkl244
   Evans JMM, 2005, BMJ-BRIT MED J, V330, P1304, DOI 10.1136/bmj.38415.708634.F7
   Everard A, 2014, ISME J, V8, P2116, DOI 10.1038/ismej.2014.45
   Faith JJ, 2013, SCIENCE, V341, P44, DOI 10.1126/science.1237439
   Fei N, 2013, ISME J, V7, P880, DOI 10.1038/ismej.2012.153
   Flint HJ, 2012, NAT REV GASTRO HEPAT, V9, P577, DOI 10.1038/nrgastro.2012.156
   He L, 2009, CELL, V137, P635, DOI 10.1016/j.cell.2009.03.016
   Hua WY, 2007, J PHARMACEUT BIOMED, V44, P931, DOI 10.1016/j.jpba.2007.03.022
   Kong WJ, 2004, NAT MED, V10, P1344, DOI 10.1038/nm1135
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Lee YS, 2006, DIABETES, V55, P2256, DOI 10.2337/db06-0006
   Lozupone C, 2005, APPL ENVIRON MICROB, V71, P8228, DOI 10.1128/AEM.71.12.8228-8235.2005
   Marchesini G, 2001, LANCET, V358, P893, DOI 10.1016/S0140-6736(01)06042-1
   Maslowski KM, 2009, NATURE, V461, P1282, DOI 10.1038/nature08530
   Moghetti P, 2000, J CLIN ENDOCR METAB, V85, P139, DOI 10.1210/jc.85.1.139
   Napolitano A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100778
   Ovreas L, 1997, APPL ENVIRON MICROB, V63, P3367
   Pinto AJ, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0043093
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Ratner R, 2005, DIABETES CARE, V28, P888, DOI 10.2337/diacare.28.4.888
   Ravussin Y, 2012, OBESITY, V20, P738, DOI 10.1038/oby.2011.111
   Reeder J, 2010, NAT METHODS, V7, P668, DOI 10.1038/nmeth0910-668b
   Santacruz A, 2009, OBESITY, V17, P1906, DOI 10.1038/oby.2009.112
   Scheen AJ, 1996, CLIN PHARMACOKINET, V30, P359, DOI 10.2165/00003088-199630050-00003
   Schloss PD, 2005, APPL ENVIRON MICROB, V71, P1501, DOI 10.1128/AEM.71.3.1501-1506.2005
   Sedova L, 2004, INT J OBESITY, V28, P719, DOI 10.1038/sj.ijo.0802613
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Tang J, 2009, J ETHNOPHARMACOL, V126, P5, DOI 10.1016/j.jep.2009.08.009
   Tang WHW, 2014, J CLIN INVEST, V124, P4204, DOI 10.1172/JCI72331
   Tibshirani R, 2002, P NATL ACAD SCI USA, V99, P6567, DOI 10.1073/pnas.082099299
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Turner RC, 1998, LANCET, V352, P854, DOI 10.1016/s0140-6736(98)07037-8
   Vijay-Kumar M, 2010, SCIENCE, V328, P228, DOI 10.1126/science.1179721
   Wang JJ, 2015, ISME J, V9, P1, DOI 10.1038/ismej.2014.99
   Wang Q, 2007, APPL ENVIRON MICROB, V73, P5261, DOI 10.1128/AEM.00062-07
   Wang TT, 2012, ISME J, V6, P320, DOI 10.1038/ismej.2011.109
   Xiao SM, 2014, FEMS MICROBIOL ECOL, V87, P357, DOI 10.1111/1574-6941.12228
   Xie WD, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0024520
   Xu J, 2015, ISME J, V9, P552, DOI 10.1038/ismej.2014.177
   Zhang CH, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms3163
   Zhang CH, 2010, ISME J, V4, P232, DOI 10.1038/ismej.2009.112
   Zhang X, 2012, PLOS ONE, V7, DOI [10.1371/journal.pone.0042529, 10.1371/journal.pone.0035700]
   Zhang YF, 2008, J CLIN ENDOCR METAB, V93, P2559, DOI 10.1210/jc.2007-2404
   Zhao GH, 2006, BIOMED CHROMATOGR, V20, P674, DOI 10.1002/bmc.580
   Zhou GC, 2001, J CLIN INVEST, V108, P1167, DOI 10.1172/JCI200113505
NR 55
TC 249
Z9 286
U1 10
U2 207
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD SEP 23
PY 2015
VL 5
AR 14405
DI 10.1038/srep14405
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA CR8JU
UT WOS:000361598400001
PM 26396057
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Salomaki-Myftari, H
   Vahatalo, LH
   Ailanen, L
   Pietila, S
   Laiho, A
   Hanninen, A
   Pursiheimo, JP
   Munukka, E
   Rintala, A
   Savontaus, E
   Pesonen, U
   Koulu, M
AF Salomaki-Myftari, Henriikka
   Vahatalo, Laura H.
   Ailanen, Liisa
   Pietila, Sami
   Laiho, Asta
   Hanninen, Arno
   Pursiheimo, Juha-Pekka
   Munukka, Eveliina
   Rintala, Anniina
   Savontaus, Eriika
   Pesonen, Ullamari
   Koulu, Markku
TI Neuropeptide Y Overexpressing Female and Male Mice Show Divergent
   Metabolic but Not Gut Microbial Responses to Prenatal Metformin Exposure
SO PLOS ONE
LA English
DT Article
ID IMPAIRED GLUCOSE-TOLERANCE; DIABETES-MELLITUS; SIGNAL PEPTIDE;
   FOLLOW-UP; HYPOTHALAMIC REGULATION; NORADRENERGIC NEURONS;
   PREPRONEUROPEPTIDE-Y; BODY-COMPOSITION; INDUCED OBESITY; ADIPOSE-TISSUE
AB Background
   Prenatal metformin exposure has been shown to improve the metabolic outcome in the offspring of high fat diet fed dams. However, if this is evident also in a genetic model of obesity and whether gut microbiota has a role, is not known.
   Methods
   The metabolic effects of prenatal metformin exposure were investigated in a genetic model of obesity, mice overexpressing neuropeptide Y in the sympathetic nervous system and in brain noradrenergic neurons (OE-NPYD beta H). Metformin was given for 18 days to the mated female mice. Body weight, body composition, glucose tolerance and serum parameters of the offspring were investigated on regular diet from weaning and sequentially on western diet (at the age of 5-7 months). Gut microbiota composition was analysed by 16S rRNA sequencing at 10-11 weeks.
   Results
   In the male offspring, metformin exposure inhibited weight gain. Moreover, weight of white fat depots and serum insulin and lipids tended to be lower at 7 months. In contrast, in the female offspring, metformin exposure impaired glucose tolerance at 3 months, and subsequently increased body weight gain, fat mass and serum cholesterol. In the gut microbiota, a decline in Erysipelotrichaceae and Odoribacter was detected in the metformin exposed offspring. Furthermore, the abundance of Sutterella tended to be decreased and Parabacteroides increased. Gut microbiota composition of the metformin exposed male offspring correlated to their metabolic phenotype.
   Conclusion
   Prenatal metformin exposure caused divergent metabolic phenotypes in the female and male offspring. Nevertheless, gut microbiota of metformin exposed offspring was similarly modified in both genders.
C1 [Salomaki-Myftari, Henriikka; Vahatalo, Laura H.; Ailanen, Liisa; Savontaus, Eriika; Pesonen, Ullamari; Koulu, Markku] Univ Turku, Dept Pharmacol Drug Dev & Therapeut, Inst Biomed, Turku, Finland.
   [Salomaki-Myftari, Henriikka; Vahatalo, Laura H.; Ailanen, Liisa] Univ Turku, DRDP, Turku, Finland.
   [Pietila, Sami; Laiho, Asta] Univ Turku, Turku Ctr Biotechnol, Bioinformat Unit, Turku, Finland.
   [Pietila, Sami; Laiho, Asta] Abo Akad Univ, Turku, Finland.
   [Hanninen, Arno; Munukka, Eveliina; Rintala, Anniina] Univ Turku, Dept Med Microbiol & Immunol, Inst Biomed, Turku, Finland.
   [Pursiheimo, Juha-Pekka] Univ Turku, Inst Biomed, Turku Clin Sequencing Lab, Turku, Finland.
C3 University of Turku; University of Turku; University of Turku; Abo
   Akademi University; University of Turku; University of Turku
RP Koulu, M (通讯作者)，Univ Turku, Dept Pharmacol Drug Dev & Therapeut, Inst Biomed, Turku, Finland.
EM markku.koulu@utu.fi
RI Munukka, Eveliina/GQP-6540-2022
OI Pesonen, Ullamari/0000-0002-9962-212X; Savontaus,
   Eriika/0000-0003-3421-0367; Keskitalo, Anniina/0000-0002-3342-4358;
   Hanninen, Arno/0000-0002-0316-4508
FU Academy of Finland [134131]; Drug Research Doctoral Programme (DRDP);
   Orion Research Foundation; Academy of Finland (AKA) [134131] Funding
   Source: Academy of Finland (AKA)
FX This study was supported by the Academy of Finland
   (http://www.aka.fi/en; grant 134131 to MK), Drug Research Doctoral
   Programme (DRDP,
   http://www.utu.fi/en/units/med/studying/postgrad/doctoral/doctoralprogra
   mmes/drdp; grant to HSM) and Orion Research Foundation
   (http://www.orion.fi/en/; grant to HSM). The funders had no role in
   study design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
CR Amer Diabet Assoc, 2014, DIABETES CARE, V37, pS14, DOI 10.2337/dc14-S014
   Balsells M, 2015, BMJ-BRIT MED J, V350, DOI 10.1136/bmj.h102
   Berkowitz SA, 2014, JAMA INTERN MED, V174, P1955, DOI 10.1001/jamainternmed.2014.5294
   Cabreiro F, 2013, CELL, V153, P228, DOI 10.1016/j.cell.2013.02.035
   Candon S, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0125448
   Carlsen SM, 2010, HUM REPROD, V25, P786, DOI 10.1093/humrep/dep444
   Carlsen SM, 2012, PEDIATRICS, V130, pE1222, DOI 10.1542/peds.2012-0346
   Caton PW, 2011, DIABETES OBES METAB, V13, P1097, DOI 10.1111/j.1463-1326.2011.01466.x
   Ding B, 2005, REGUL PEPTIDES, V127, P45, DOI 10.1016/j.regpep.2004.10.011
   Duca FA, 2015, NAT MED, V21, P506, DOI 10.1038/nm.3787
   Everard A, 2014, ISME J, V8, P2116, DOI 10.1038/ismej.2014.45
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Geurts L, 2011, FRONT MICROBIOL, V2, DOI 10.3389/fmicb.2011.00149
   Hildebrandt MA, 2009, GASTROENTEROLOGY, V137, P1716, DOI 10.1053/j.gastro.2009.08.042
   Hirsch D, 2012, CELL MOL NEUROBIOL, V32, P645, DOI 10.1007/s10571-011-9793-z
   Hou XG, 2010, BIOCHEM BIOPH RES CO, V396, P199, DOI 10.1016/j.bbrc.2010.04.017
   Hundal RS, 2000, DIABETES, V49, P2063, DOI 10.2337/diabetes.49.12.2063
   Hwang LL, 2010, OBESITY, V18, P463, DOI 10.1038/oby.2009.273
   Ijas H, 2015, BJOG-INT J OBSTET GY, V122, P994, DOI 10.1111/1471-0528.12964
   Ijas H, 2011, BJOG-INT J OBSTET GY, V118, P880, DOI 10.1111/j.1471-0528.2010.02763.x
   Kallio J, 2001, FASEB J, V15, P1242, DOI 10.1096/fj.00-0436fje
   Kalliomaki M, 2008, AM J CLIN NUTR, V87, P534, DOI 10.1093/ajcn/87.3.534
   Karvonen MK, 1998, NAT MED, V4, P1434, DOI 10.1038/4027
   Karvonen MK, 2001, ATHEROSCLEROSIS, V159, P145, DOI 10.1016/S0021-9150(01)00468-3
   Keski-Nisula L, 2013, ACTA PAEDIATR, V102, P480, DOI 10.1111/apa.12186
   Koulu M, 2004, ANN MED, V36, P232, DOI 10.1080/07853890410031236
   Kozich JJ, 2013, APPL ENVIRON MICROB, V79, P5112, DOI 10.1128/AEM.01043-13
   Kuo LE, 2007, NAT MED, V13, P803, DOI 10.1038/nm1611
   Langille MGI, 2013, NAT BIOTECHNOL, V31, P814, DOI 10.1038/nbt.2676
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Ley RE, 2005, P NATL ACAD SCI USA, V102, P11070, DOI 10.1073/pnas.0504978102
   Ley RE, 2006, NATURE, V444, P1022, DOI 10.1038/4441022a
   Lv WS, 2012, BRAIN RES, V1444, P11, DOI 10.1016/j.brainres.2012.01.028
   Maida A, 2011, DIABETOLOGIA, V54, P339, DOI 10.1007/s00125-010-1937-z
   Makino H, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0078331
   Mannucci E, 2001, DIABETES CARE, V24, P489, DOI 10.2337/diacare.24.3.489
   Markle JGM, 2013, SCIENCE, V339, P1084, DOI 10.1126/science.1233521
   Matthews L, 2009, NUCLEIC ACIDS RES, V37, pD619, DOI 10.1093/nar/gkn863
   Myles IA, 2013, J IMMUNOL, V191, P3200, DOI 10.4049/jimmunol.1301057
   Napolitano A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100778
   Niskanen L, 2000, EXP CLIN ENDOCR DIAB, V108, P235, DOI 10.1055/s-2000-7748
   Nordman S, 2005, EXP CLIN ENDOCR DIAB, V113, P282, DOI 10.1055/s-2005-865650
   Onken B, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0008758
   Pernicova I, 2014, NAT REV ENDOCRINOL, V10, P143, DOI 10.1038/nrendo.2013.256
   Rautava S, 2012, NAT REV GASTRO HEPAT, V9, P565, DOI 10.1038/nrgastro.2012.144
   Ro TB, 2012, SCAND J CLIN LAB INV, V72, P570, DOI 10.3109/00365513.2012.712319
   Rowan JA, 2011, DIABETES CARE, V34, P2279, DOI 10.2337/dc11-0660
   Rowan JA, 2010, DIABETES CARE, V33, P9, DOI 10.2337/dc09-1407
   Ruohonen ST, 2008, DIABETES, V57, P1517, DOI 10.2337/db07-0722
   Ruohonen Suvi T, 2012, Int J Pept, V2012, P452524, DOI 10.1155/2012/452524
   Sainsbury A, 2002, BEST PRACT RES CL EN, V16, P623, DOI 10.1053/beem.2002.0230
   Salomaki H, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0115778
   Salomaki H, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0056594
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Spencer MD, 2011, GASTROENTEROLOGY, V140, P976, DOI 10.1053/j.gastro.2010.11.049
   STANLEY BG, 1986, PEPTIDES, V7, P1189
   Stepensky D, 2002, DRUG METAB DISPOS, V30, P861, DOI 10.1124/dmd.30.8.861
   Syngelaki A, 2016, NEW ENGL J MED, V374, P434, DOI 10.1056/NEJMoa1509819
   Tong JF, 2011, NUTR DIABETES, V1, DOI 10.1038/nutd.2011.3
   Tormo-Badia N, 2014, SCAND J IMMUNOL, V80, P250, DOI 10.1111/sji.12205
   Tremaroli V, 2012, NATURE, V489, P242, DOI 10.1038/nature11552
   Vahatalo LH, 2015, ACTA PHYSIOL, V213, P902, DOI 10.1111/apha.12436
   Wulffele MG, 2004, J INTERN MED, V256, P1, DOI 10.1111/j.1365-2796.2004.01328.x
   Xiao SM, 2014, FEMS MICROBIOL ECOL, V87, P357, DOI 10.1111/1574-6941.12228
   Xie ZL, 2011, DIABETES, V60, P1770, DOI 10.2337/db10-0351
   Yang T, 2002, CELL, V110, P489, DOI 10.1016/S0092-8674(02)00872-3
   ZARJEVSKI N, 1993, ENDOCRINOLOGY, V133, P1753, DOI 10.1210/en.133.4.1753
   Zhang L, 2014, MOL METAB, V3, P581, DOI 10.1016/j.molmet.2014.05.001
   Zhang X, 2015, SCI REP-UK, V5, DOI 10.1038/srep14405
NR 69
TC 26
Z9 26
U1 0
U2 5
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 28
PY 2016
VL 11
IS 9
AR e0163805
DI 10.1371/journal.pone.0163805
PG 19
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA DX2BH
UT WOS:000384171400057
PM 27681875
OA Green Published, gold, Green Submitted
DA 2023-06-08
ER

PT S
AU Pryor, R
   Martinez-Martinez, D
   Quintaneiro, L
   Cabreiro, F
AF Pryor, Rosina
   Martinez-Martinez, Daniel
   Quintaneiro, Leonor
   Cabreiro, Filipe
BE Insel, PA
TI The Role of the Microbiome in Drug Response
SO ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 60
SE Annual Review of Pharmacology and Toxicology
LA English
DT Review; Book Chapter
DE microbiome; drugs; metabolism; antipsychotics; metformin; cancer
ID GLUCAGON-LIKE PEPTIDE-1; CHAIN FATTY-ACIDS; GUT MICROBIOTA;
   COLORECTAL-CANCER; INTESTINAL MICROBIOTA; METFORMIN ALTERS; C. ELEGANS;
   GLUCOSE; IMPACT; METABOLISM
AB The microbiome is known to regulate many aspects of host health and disease and is increasingly being recognized as a key mediator of drug action. However, investigating the complex multidirectional relationships between drugs, the microbiota, and the host is a challenging endeavor, and the biological mechanisms that underpin these interactions are often not well understood. In this review, we outline the current evidence that supports a role for the microbiota as a contributor to both the therapeutic benefits and side effects of drugs, with a particular focus on those used to treat mental disorders, type 2 diabetes, and cancer. We also provide a snapshot of the experimental and computational tools that are currently available for the dissection of drug microbiota host interactions. The advancement of knowledge in this area may ultimately pave the way for the development of novel microbiota-based strategies that can be used to improve treatment outcomes.
C1 [Pryor, Rosina; Martinez-Martinez, Daniel; Quintaneiro, Leonor; Cabreiro, Filipe] MRC London Inst Med Sci, London W12 0NN, England.
   [Pryor, Rosina; Martinez-Martinez, Daniel; Quintaneiro, Leonor; Cabreiro, Filipe] Imperial Coll London, Inst Clin Sci, Hammersmith Hosp Campus, London W12 0NN, England.
   [Quintaneiro, Leonor] UCL, Inst Struct & Mol Biol, London WC1E 6BT, England.
   [Quintaneiro, Leonor] Birkbeck, London WC1E 6BT, England.
C3 Imperial College London; University of London; Birkbeck University
   London; University College London
RP Cabreiro, F (通讯作者)，MRC London Inst Med Sci, London W12 0NN, England.; Cabreiro, F (通讯作者)，Imperial Coll London, Inst Clin Sci, Hammersmith Hosp Campus, London W12 0NN, England.
EM f.cabreiro@lms.mrc.ac.uk
OI Martinez-Martinez, Daniel/0000-0001-8468-1357
FU Wellcome Trust/Royal Society [102532/Z/12/Z, 102531/Z/13/A]; Medical
   Research Council [MC-A654-5QC80]; MRC [MC_UP_1605/6] Funding Source:
   UKRI
FX F.C. acknowledges funding from the Wellcome Trust/Royal Society
   (102532/Z/12/Z and 102531/Z/13/A) and Medical Research Council
   (MC-A654-5QC80).
CR Afiahayati, 2015, DNA RES, V22, P69, DOI 10.1093/dnares/dsu041
   Al-Salami H, 2008, EUR J DRUG METAB PH, V33, P101
   Alolga RN, 2016, SCI REP-UK, V6, DOI 10.1038/srep27671
   Aranda F, 2015, ONCOGENE, V34, P3053, DOI 10.1038/onc.2014.234
   Aziz RK, 2011, BMC BIOINFORMATICS, V12, DOI 10.1186/1471-2105-12-S7-A10
   Bahne E, 2016, DIABETES OBES METAB, V18, P955, DOI 10.1111/dom.12697
   Bahr SM, 2015, TRANSL PSYCHIAT, V5, DOI 10.1038/tp.2015.135
   Bahr SM, 2015, EBIOMEDICINE, V2, P1725, DOI 10.1016/j.ebiom.2015.10.018
   Bai J, 2016, J ETHNOPHARMACOL, V194, P717, DOI 10.1016/j.jep.2016.10.043
   Baldini F, 2019, BIOINFORMATICS, V35, P2332, DOI 10.1093/bioinformatics/bty941
   Baldwin C, 2010, NUTR CANCER, V62, P371, DOI 10.1080/01635580903407197
   Bauer PV, 2018, CELL METAB, V27, P101, DOI 10.1016/j.cmet.2017.09.019
   Baxter NT, 2019, MSPHERE, V4, DOI [10.1128/mSphere.00528-18, 10.1128/msphere.00528-18]
   Ben Guebila M, 2016, NPJ SYST BIOL APPL, V2, DOI 10.1038/npjsba.2016.13
   Bohnert JA, 2011, J ANTIMICROB CHEMOTH, V66, P2057, DOI 10.1093/jac/dkr258
   Bolyen E, 2019, NAT BIOTECHNOL, V37, P852, DOI 10.1038/s41587-019-0209-9
   BONORA E, 1984, CURR MED RES OPIN, V9, P47, DOI 10.1185/03007998409109558
   Burokas A, 2017, BIOL PSYCHIAT, V82, P472, DOI 10.1016/j.biopsych.2016.12.031
   Buse JB, 2016, DIABETES CARE, V39, P198, DOI 10.2337/dc15-0488
   Cabreiro F, 2013, CELL, V153, P228, DOI 10.1016/j.cell.2013.02.035
   Cheng K, 2017, MICROBIOME, V5, DOI 10.1186/s40168-017-0375-2
   Christiansen CB, 2018, AM J PHYSIOL-GASTR L, V315, pG53, DOI 10.1152/ajpgi.00346.2017
   Codagnone MG, 2019, BIOL PSYCHIAT, V85, P150, DOI 10.1016/j.biopsych.2018.06.014
   Cordes H, 2018, NPJ SYST BIOL APPL, V4, DOI 10.1038/s41540-018-0048-1
   Cougnoux A, 2016, GUT, V65, P278, DOI 10.1136/gutjnl-2014-307241
   Cussotto S, 2019, PSYCHOPHARMACOLOGY, V236, P1671, DOI 10.1007/s00213-018-5006-5
   Dahan D, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.01323
   Davey KJ, 2013, TRANSL PSYCHIAT, V3, DOI 10.1038/tp.2013.83
   David LA, 2014, NATURE, V505, P559, DOI 10.1038/nature12820
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   De Vadder F, 2014, CELL, V156, P84, DOI 10.1016/j.cell.2013.12.016
   Desbonnet L, 2010, NEUROSCIENCE, V170, P1179, DOI 10.1016/j.neuroscience.2010.08.005
   Din MO, 2016, NATURE, V536, P81, DOI 10.1038/nature18930
   Dubin K, 2016, NAT COMMUN, V7, DOI 10.1038/ncomms10391
   Elbere I, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0204317
   Ellerby HM, 1999, NAT MED, V5, P1032, DOI 10.1038/12469
   Eren AM, 2015, PEERJ, V3, DOI 10.7717/peerj.1319
   Falony G, 2016, SCIENCE, V352, P560, DOI 10.1126/science.aad3503
   Feng R, 2015, SCI REP-UK, V5, DOI 10.1038/srep12155
   Velazquez YF, 2017, ENVIRON SCI POLLUT R, V24, P6779, DOI 10.1007/s11356-017-8413-y
   Flowers SA, 2019, PHARMACOTHERAPY, V39, P161, DOI 10.1002/phar.2214
   Flowers SA, 2017, PHARMACOTHERAPY, V37, P261, DOI 10.1002/phar.1890
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Fuller AT, 1937, LANCET, V1, P194
   Garcia-Gonzalez AP, 2017, CELL, V169, P431, DOI 10.1016/j.cell.2017.03.046
   Geller LT, 2017, SCIENCE, V357, P1156, DOI 10.1126/science.aah5043
   Gershon MD, 1999, HOSP PRACT, V34, P31, DOI 10.3810/hp.1999.07.153
   Giacomoni F, 2015, BIOINFORMATICS, V31, P1493, DOI 10.1093/bioinformatics/btu813
   Goodrich JK, 2014, CELL, V158, P250, DOI 10.1016/j.cell.2014.06.037
   Gopalakrishnan V, 2018, SCIENCE, V359, P97, DOI 10.1126/science.aan4236
   Gu YY, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-01682-2
   Guthrie L, 2017, NPJ BIOFILMS MICROBI, V3, DOI 10.1038/s41522-017-0034-1
   Haiser HJ, 2014, GUT MICROBES, V5, P233, DOI 10.4161/gmic.27915
   Haiser HJ, 2013, SCIENCE, V341, P295, DOI 10.1126/science.1235872
   Hanahan D, 2011, CELL, V144, P646, DOI 10.1016/j.cell.2011.02.013
   Harcombe WR, 2014, CELL REP, V7, P1104, DOI 10.1016/j.celrep.2014.03.070
   Heirendt L, 2019, NAT PROTOC, V14, P639, DOI 10.1038/s41596-018-0098-2
   Hu Y, 2016, CARCINOGENESIS, V37, P366, DOI 10.1093/carcin/bgw019
   Iida N, 2013, SCIENCE, V342, P967, DOI 10.1126/science.1240527
   Islam KBMS, 2011, GASTROENTEROLOGY, V141, P1773, DOI 10.1053/j.gastro.2011.07.046
   Jacquelot N, 2016, J CLIN INVEST, V126, P921, DOI 10.1172/JCI80071
   Kao ACC, 2018, TRANSL PSYCHIAT, V8, DOI 10.1038/s41398-018-0116-8
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kato S, 2017, CLIN EXP PHARMACOL P, V44, P1017, DOI 10.1111/1440-1681.12792
   Kim D, 2016, GENOME RES, V26, P1721, DOI 10.1101/gr.210641.116
   Kroemer G, 2013, ANNU REV IMMUNOL, V31, P51, DOI 10.1146/annurev-immunol-032712-100008
   Kundu P, 2017, CELL, V171, P1481, DOI 10.1016/j.cell.2017.11.024
   LALANI AKA, 2018, J CLIN ONCOL S6, V36
   Larraufie P, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-017-18259-0
   Leclercq S, 2017, NAT COMMUN, V8, DOI 10.1038/ncomms15062
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Li JP, 2017, 2017 IEEE 2ND INTERNATIONAL CONFERENCE ON OPTO-ELECTRONIC INFORMATION PROCESSING (ICOIP), P1, DOI 10.1109/OPTIP.2017.8030687
   Lin XB, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0039764
   Liu F, 2018, MOL AUTISM, V9, DOI 10.1186/s13229-018-0251-3
   Macedo D, 2017, J AFFECT DISORDERS, V208, P22, DOI 10.1016/j.jad.2016.09.012
   Machado D, 2018, NUCLEIC ACIDS RES, V46, P7542, DOI 10.1093/nar/gky537
   Magnusdottir S, 2017, NAT BIOTECHNOL, V35, P81, DOI 10.1038/nbt.3703
   Maier L, 2018, NATURE, V555, P623, DOI 10.1038/nature25979
   Martinez X, 2016, SCI REP-UK, V6, DOI 10.1038/srep26447
   Matson V, 2018, SCIENCE, V359, P104, DOI 10.1126/science.aao3290
   McIver LJ, 2018, BIOINFORMATICS, V34, P1235, DOI 10.1093/bioinformatics/btx754
   Montassier E, 2015, ALIMENT PHARM THER, V42, P515, DOI 10.1111/apt.13302
   Moreira GV, 2018, J NUTR BIOCHEM, V62, P143, DOI 10.1016/j.jnutbio.2018.07.009
   Moreno L, 2013, EXPERT OPIN DRUG DIS, V8, P363, DOI 10.1517/17460441.2013.768984
   Morgan AP, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0115225
   Nakatsu G, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms9727
   Napolitano A, 2014, PLOS ONE, V9
   Noronha A, 2019, NUCLEIC ACIDS RES, V47, pD614, DOI 10.1093/nar/gky992
   Norvaisas Povilas, 2018, Current Opinion in Systems Biology, V10, P34, DOI 10.1016/j.coisb.2018.05.006
   Nurk S, 2017, GENOME RES, V27, P824, DOI 10.1101/gr.213959.116
   Olivares M, 2018, DIABETOLOGIA, V61, P1838, DOI 10.1007/s00125-018-4647-6
   Ounit R, 2016, BIOINFORMATICS, V32, P3823, DOI 10.1093/bioinformatics/btw542
   Panebianco C, 2018, CANCER CHEMOTH PHARM, V81, P773, DOI 10.1007/s00280-018-3549-0
   Parkin DM, 2006, INT J CANCER, V118, P3030, DOI 10.1002/ijc.21731
   Plovier H, 2017, NAT MED, V23, P107, DOI 10.1038/nm.4236
   Poussin C, 2018, DRUG DISCOV TODAY, V23, P1644, DOI 10.1016/j.drudis.2018.06.005
   Pryor R, 2015, BIOCHEM J, V471, P307, DOI 10.1042/BJ20150497
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Rena G, 2017, DIABETOLOGIA, V60, P1577, DOI 10.1007/s00125-017-4342-z
   Rodier PM, 1996, J COMP NEUROL, V370, P247, DOI 10.1002/(SICI)1096-9861(19960624)370:2<247::AID-CNE8>3.0.CO;2-2
   Rothschild D, 2018, NATURE, V555, P210, DOI 10.1038/nature25973
   Routy B, 2018, SCIENCE, V359, P91, DOI 10.1126/science.aan3706
   Ruttkies C, 2018, GIGASCIENCE, V8
   Sahin M, 2007, J DIABETES COMPLICAT, V21, P118, DOI 10.1016/j.jdiacomp.2005.10.005
   Sarkar A, 2016, TRENDS NEUROSCI, V39, P763, DOI 10.1016/j.tins.2016.09.002
   Schloss PD, 2009, APPL ENVIRON MICROB, V75, P7537, DOI 10.1128/AEM.01541-09
   Schoener CA, 2013, J DRUG DELIV SCI TEC, V23, P111, DOI 10.1016/S1773-2247(13)50018-9
   Scott TA, 2017, CELL, V169, P442, DOI 10.1016/j.cell.2017.03.040
   Seemann T, 2014, BIOINFORMATICS, V30, P2068, DOI 10.1093/bioinformatics/btu153
   Sharma AK, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-10203-6
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Sivan A, 2015, SCIENCE, V350, P1084, DOI 10.1126/science.aac4255
   Spanogiannopoulos P, 2016, NAT REV MICROBIOL, V14, P273, DOI 10.1038/nrmicro.2016.17
   Stepensky D, 2002, DRUG METAB DISPOS, V30, P861, DOI 10.1124/dmd.30.8.861
   Strebhardt K, 2008, NAT REV CANCER, V8, P473, DOI 10.1038/nrc2394
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Sun YZ, 2018, FRONT CELL INFECT MI, V8, DOI 10.3389/fcimb.2018.00424
   Thiele Ines, 2017, Curr Opin Syst Biol, V4, P43, DOI 10.1016/j.coisb.2017.06.001
   Tian Y, 2019, DRUG METAB DISPOS, V47, P86, DOI 10.1124/dmd.118.083691
   Toda T, 2009, DRUG METAB PHARMACOK, V24, P201, DOI 10.2133/dmpk.24.201
   Tolhurst G, 2012, DIABETES, V61, P364, DOI 10.2337/db11-1019
   Tomas J, 2016, P NATL ACAD SCI USA, V113, pE5934, DOI 10.1073/pnas.1612559113
   Trinder M, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.00751
   Tyanova S, 2015, PROTEOMICS, V15, P1453, DOI 10.1002/pmic.201400449
   Upton RN, 2016, PEDIATR ANESTH, V26, P1036, DOI 10.1111/pan.12995
   Veber DF, 2002, J MED CHEM, V45, P2615, DOI 10.1021/jm020017n
   Vetizou M, 2015, SCIENCE, V350, P1079, DOI 10.1126/science.aad1329
   Viaud S, 2013, SCIENCE, V342, P971, DOI 10.1126/science.1240537
   VORHEES CV, 1987, PSYCHOPHARMACOLOGY, V92, P173
   Wahlstrom A, 2016, CELL METAB, V24, P41, DOI 10.1016/j.cmet.2016.05.005
   Wallace BD, 2015, CHEM BIOL, V22, P1238, DOI 10.1016/j.chembiol.2015.08.005
   Wang F, 2017, PNAS, V115, P157
   Wang L, 2016, SCI REP-UK, V6, DOI [10.1038/srep38380, 10.1038/srep33251, 10.1038/srep20004]
   Wang Qing, 2019, Biophys Rev, V11, P55, DOI 10.1007/s12551-018-0491-7
   Wang Y, 2017, METABOLISM, V70, P72, DOI 10.1016/j.metabol.2017.02.003
   Westreich ST, 2018, BMC BIOINFORMATICS, V19, DOI 10.1186/s12859-018-2189-z
   Wood DE, 2014, GENOME BIOL, V15, DOI 10.1186/gb-2014-15-3-r46
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Yan A, 2018, ACS INFECT DIS, V4, P68, DOI 10.1021/acsinfecdis.7b00166
   Yan XF, 2016, J DIABETES RES, V2016, DOI 10.1155/2016/2093171
   Yu TC, 2017, CELL, V170, P548, DOI 10.1016/j.cell.2017.07.008
   Yue SJ, 2019, AM J PHYSIOL-ENDOC M, V316, pE73, DOI 10.1152/ajpendo.00256.2018
   Zhang Q, 2018, EXP BIOL MED, V243, P34, DOI 10.1177/1535370217743765
   Zhang XY, 2017, DIABETES THER, V8, P293, DOI 10.1007/s13300-017-0226-y
NR 144
TC 20
Z9 21
U1 6
U2 47
PU ANNUAL REVIEWS
PI PALO ALTO
PA 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0897 USA
SN 0362-1642
EI 1545-4304
BN 978-0-8243-0460-7
J9 ANNU REV PHARMACOL
JI Annu. Rev. Pharmacol. Toxicol.
PY 2020
VL 60
BP 417
EP 435
DI 10.1146/annurev-pharmtox-010919-023612
PG 19
WC Pharmacology & Pharmacy; Toxicology
WE Book Citation Index– Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Toxicology
GA BO2PU
UT WOS:000507470800022
PM 31386593
DA 2023-06-08
ER

PT J
AU Brandt, A
   Hernandez-Arriaga, A
   Kehm, R
   Sanchez, V
   Jin, CJ
   Nier, A
   Baumann, A
   Camarinha-Silva, A
   Bergheim, I
AF Brandt, Annette
   Hernandez-Arriaga, Angelica
   Kehm, Richard
   Sanchez, Victor
   Jin, Cheng Jun
   Nier, Anika
   Baumann, Anja
   Camarinha-Silva, Amelia
   Bergheim, Ina
TI Metformin attenuates the onset of non-alcoholic fatty liver disease and
   affects intestinal microbiota and barrier in small intestine
SO SCIENTIFIC REPORTS
LA English
DT Article
ID INSULIN-RESISTANCE; HEPATIC STEATOSIS; MICE; STEATOHEPATITIS; PROTECTS;
   SUPPLEMENTATION; COMMUNITIES
AB The antidiabetic drug metformin has been proposed to affect non-alcoholic fatty liver disease (NAFLD) through its effects on intestinal microbiota and barrier function. However, so far most studies focused on long-term effects and more progressed disease stages. The aim of this study was to assess in two experimental settings, if the onset of NAFLD is associated with changes of intestinal microbiota and barrier function and to determine effects of metformin herein. C57BL/6J mice were fed a liquid control diet (C) or fat-, fructose- and cholesterol-rich diet (FFC) for four days or six weeks +/- 300 mg/kg BW/day metformin (Met). Markers of liver health, intestinal barrier function and microbiota composition were assessed. Metformin treatment markedly attenuated FFC-induced NAFLD in both experiments with markers of inflammation and lipidperoxidation in livers of FFC + Met-fed mice being almost at the level of controls. Metformin treatment attenuated the loss of tight junction proteins in small intestine and the increase of bacterial endotoxin levels in portal plasma. Changes of intestinal microbiota found in FFC-fed mice were also significantly blunted in FFC + Met-fed mice. Taken together, protective effects of metformin on the onset of NAFLD are associated with changes of intestinal microbiota composition and lower translocation of bacterial endotoxins.
C1 [Brandt, Annette; Sanchez, Victor; Nier, Anika; Baumann, Anja; Bergheim, Ina] Univ Vienna, Dept Nutr Sci, RF Mol Nutr Sci, A-1090 Vienna, Austria.
   [Hernandez-Arriaga, Angelica; Camarinha-Silva, Amelia] Univ Hohenheim, Inst Anim Sci, D-70599 Stuttgart, Germany.
   [Kehm, Richard; Jin, Cheng Jun] Friedrich Schiller Univ Jena, Inst Nutr, SD Model Syst Mol Nutr, D-07743 Jena, Germany.
   [Kehm, Richard] German Inst Human Nutr Potsdam Rehbruecke DIfE, Dept Mol Toxicol, D-14558 Nuthetal, Germany.
C3 University of Vienna; University Hohenheim; Friedrich Schiller
   University of Jena; Deutsches Institut fur Ernahrungsforschung
   Potsdam-Rehbrucke (DIfE)
RP Bergheim, I (通讯作者)，Univ Vienna, Dept Nutr Sci, RF Mol Nutr Sci, A-1090 Vienna, Austria.
EM ina.bergheim@univie.ac.at
RI Brandt, Annette/HNC-3045-2023
OI Kehm, Richard/0000-0002-2993-4291; Camarinha Silva,
   Amelia/0000-0001-7814-6569; Hernandez-Arriaga,
   Angelica/0000-0002-9980-4695; Nier, Anika/0000-0003-3772-2261
FU Federal Ministry of Education and Research [FKZ: 01KU1214A]; state of
   Baden-Wurttemberg through bw-HPC; University of Vienna
FX The present work was funded by a grant from Federal Ministry of
   Education and Research (FKZ: 01KU1214A to I.B.). A.C.S. acknowledge the
   support by the state of Baden-Wurttemberg through bw-HPC. We would like
   to thank Iweta Metzger for assistance during analyzing microbiota data.
   Open access funding provided by University of Vienna.
CR Bajaj JS, 2012, AM J PHYSIOL-GASTR L, V303, pG675, DOI 10.1152/ajpgi.00152.2012
   Boursier J, 2016, HEPATOLOGY, V63, P764, DOI 10.1002/hep.28356
   Brandt A, 2017, NUTRIENTS, V9, DOI 10.3390/nu9091013
   BRAY JR, 1957, ECOL MONOGR, V27, P326, DOI 10.2307/1942268
   Budick-Harmelin N, 2012, LIPIDS HEALTH DIS, V11, DOI 10.1186/1476-511X-11-66
   Camarinha-Silva A, 2014, ENVIRON MICROBIOL, V16, P2939, DOI 10.1111/1462-2920.12362
   Chen F, 2009, HEPATOLOGY, V50, P1914, DOI 10.1002/hep.23203
   CLARKE KR, 2001, CHANGES MARINE COMMU
   David LA, 2014, NATURE, V505, P559, DOI 10.1038/nature12820
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Engstler AJ, 2017, MOL NUTR FOOD RES, V61, DOI 10.1002/mnfr.201600985
   Fan J, 2002, J IMMUNOL, V168, P5252, DOI 10.4049/jimmunol.168.10.5252
   Feng WH, 2017, J DIABETES, V9, P800, DOI 10.1111/1753-0407.12555
   Foretz M, 2010, J CLIN INVEST, V120, P2355, DOI 10.1172/JCI40671
   Green CJ, 2019, DIABETES OBES METAB, V21, P749, DOI 10.1111/dom.13592
   Jensen BAH, 2016, METABOLISM, V65, P1706, DOI 10.1016/j.metabol.2016.09.002
   Jin CJ, 2015, BRIT J NUTR, V114, P1745, DOI 10.1017/S0007114515003621
   Kaewtapee C, 2017, J ANIM SCI BIOTECHNO, V8, DOI 10.1186/s40104-017-0168-2
   Karise Iara, 2017, Biochim Open, V4, P19, DOI 10.1016/j.biopen.2017.01.002
   Kelly B, 2015, J BIOL CHEM, V290, P20348, DOI 10.1074/jbc.M115.662114
   Kirpich IA, 2015, CLIN BIOCHEM, V48, P923, DOI 10.1016/j.clinbiochem.2015.06.023
   Kita Y, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0043056
   Kleiner DE, 2005, HEPATOLOGY, V41, P1313, DOI 10.1002/hep.20701
   Kozich JJ, 2013, APPL ENVIRON MICROB, V79, P5112, DOI 10.1128/AEM.01043-13
   Lankelma JM, 2017, PLOS NEGLECT TROP D, V11, DOI 10.1371/journal.pntd.0005548
   Lanthier N, 2010, AM J PHYSIOL-GASTR L, V298, pG107, DOI 10.1152/ajpgi.00391.2009
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Li TT, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19103075
   Li Y, 2011, CELL METAB, V13, P376, DOI 10.1016/j.cmet.2011.03.009
   Lin HZ, 2000, NAT MED, V6, P998, DOI 10.1038/79697
   Liu XJ, 2018, LAB INVEST, V98, P1184, DOI 10.1038/s41374-018-0074-z
   Ma W, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.01336
   Manzhalii E, 2017, J DIGEST DIS, V18, P698, DOI 10.1111/1751-2980.12561
   Maximos M, 2015, HEPATOLOGY, V61, P153, DOI 10.1002/hep.27395
   Miele L, 2009, HEPATOLOGY, V49, P1877, DOI 10.1002/hep.22848
   Nair S, 2004, ALIMENT PHARM THERAP, V20, P23, DOI 10.1111/j.1365-2036.2004.02025.x
   Nier A, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0183282
   Onishi JC, 2017, MICROBIOL-SGM, V163, P1189, DOI 10.1099/mic.0.000496
   Rena G, 2017, DIABETOLOGIA, V60, P1577, DOI 10.1007/s00125-017-4342-z
   Said A, 2017, ANN HEPATOL, V16, P538, DOI 10.5604/01.3001.0010.0284
   Schultz A, 2013, INT J MOL SCI, V14, P21873, DOI 10.3390/ijms141121873
   Sellmann C, 2017, EUR J NUTR, V56, P2519, DOI 10.1007/s00394-016-1287-9
   Sellmann C, 2015, J NUTR, V145, P2280, DOI 10.3945/jn.115.215517
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Spruss A, 2012, LAB INVEST, V92, P1020, DOI 10.1038/labinvest.2012.75
   Spruss A, 2011, ANTIOXID REDOX SIGN, V14, P2121, DOI 10.1089/ars.2010.3263
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Turnbaugh PJ, 2009, SCI TRANSL MED, V1, DOI 10.1126/scitranslmed.3000322
   Vandenbroucke RE, 2013, EMBO MOL MED, V5, P1000, DOI 10.1002/emmm.201202100
   Volynets V, 2012, DIGEST DIS SCI, V57, P1932, DOI 10.1007/s10620-012-2112-9
   Volynets V, 2010, J LIPID RES, V51, P3414, DOI 10.1194/jlr.M007179
   Wagnerberger S, 2012, BRIT J NUTR, V107, P1727, DOI 10.1017/S0007114511004983
   Wang Q, 2007, APPL ENVIRON MICROB, V73, P5261, DOI 10.1128/AEM.00062-07
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Xu ZJ, 2010, DIGEST DIS SCI, V55, P931, DOI 10.1007/s10620-009-0815-3
   Xue L, 2017, SCI REP-UK, V7, DOI 10.1038/srep45176
   Younossi ZM, 2016, HEPATOLOGY, V64, P73, DOI 10.1002/hep.28431
   Zhou D, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-01751-y
   Zhou GC, 2001, J CLIN INVEST, V108, P1167, DOI 10.1172/JCI200113505
   Zhou ZY, 2016, ACTA PHARMACOL SIN, V37, P1063, DOI 10.1038/aps.2016.21
NR 60
TC 58
Z9 62
U1 0
U2 13
PU NATURE RESEARCH
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD APR 30
PY 2019
VL 9
AR 6668
DI 10.1038/s41598-019-43228-0
PG 14
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA HW0DM
UT WOS:000466351100027
PM 31040374
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Zhang, EY
   Jin, LH
   Wang, YM
   Tu, J
   Zheng, RR
   Ding, LL
   Fang, ZP
   Fan, MJ
   Al-Abdullah, I
   Natarajan, R
   Ma, K
   Wang, ZT
   Riggs, AD
   Shuck, SC
   Yang, L
   Huang, WD
AF Zhang, Eryun
   Jin, Lihua
   Wang, Yangmeng
   Tu, Jui
   Zheng, Ruirong
   Ding, Lili
   Fang, Zhipeng
   Fan, Mingjie
   Al-Abdullah, Ismail
   Natarajan, Rama
   Ma, Ke
   Wang, Zhengtao
   Riggs, Arthur D.
   Shuck, Sarah C.
   Yang, Li
   Huang, Wendong
TI Intestinal AMPK modulation of microbiota mediates crosstalk with brown
   fat to control thermogenesis
SO NATURE COMMUNICATIONS
LA English
DT Article
ID ACTIVATED PROTEIN-KINASE; GUT MICROBIOME; ADIPOSE-TISSUE;
   INSULIN-RESISTANCE; METFORMIN ALTERS; GLUCOSE; METHYLGLYOXAL;
   HOMEOSTASIS; OBESITY; METAGENOME
AB The energy-dissipating capacity of brown adipose tissue through thermogenesis can be targeted to improve energy balance. Mammalian 5 '-AMP-activated protein kinase, a key nutrient sensor for maintaining cellular energy status, is a known therapeutic target in Type II diabetes. Despite its well-established roles in regulating glucose metabolism in various tissues, the functions of AMPK in the intestine remain largely unexplored. Here we show that AMPK alpha 1 deficiency in the intestine results in weight gain and impaired glucose tolerance under high fat diet feeding, while metformin administration fails to ameliorate these metabolic disorders in intestinal AMPK alpha 1 knockout mice. Further, AMPK alpha 1 in the intestine communicates with brown adipose tissue to promote thermogenesis. Mechanistically, we uncover a link between intestinal AMPK alpha 1 activation and BAT thermogenic regulation through modulating anti-microbial peptide-controlled gut microbiota and the metabolites. Our findings identify AMPK alpha 1-mediated mechanisms of intestine-BAT communication that may partially underlie the therapeutic effects of metformin.
   Mammalian 5 '-AMP-activated protein kinase (AMPK) is a nutrient sensor and a therapeutic target for Type 2 Diabetes. Here the authors report that intestinal AMPK modulates brown adipose tissue thermogenesis through anti-microbial peptide controlled gut microbiota and may partially underlie the anti-diabetic effects of metformin.
C1 [Zhang, Eryun; Zheng, Ruirong; Ding, Lili; Wang, Zhengtao; Yang, Li] Shanghai Univ Tradit Chinese Med, Inst Chinese Mat Med, Shanghai Key Lab Compound Chinese Med, Shanghai, Peoples R China.
   [Zhang, Eryun; Zheng, Ruirong; Ding, Lili; Wang, Zhengtao; Yang, Li] Shanghai Univ Tradit Chinese Med, Inst Chinese Mat Med, Minist Educ MOE Key Lab Standardizat Chinese Med, Shanghai, Peoples R China.
   [Zhang, Eryun; Jin, Lihua; Wang, Yangmeng; Tu, Jui; Ding, Lili; Fang, Zhipeng; Fan, Mingjie; Natarajan, Rama; Ma, Ke; Riggs, Arthur D.; Huang, Wendong] City Hope Natl Med Ctr, Beckman Res Inst, Dept Diabet Complicat & Metab, Arthur Riggs Diabet & Metab Res Inst, Duarte, CA 91010 USA.
   [Tu, Jui; Huang, Wendong] City Hope Natl Med Ctr, Irell & Manella Grad Sch Biol Sci, 1500 E Duarte Rd, Duarte, CA 91010 USA.
   [Al-Abdullah, Ismail] City Hope Natl Med Ctr, Arthur Riggs Diabet & Metab Res Inst, Beckman Res Inst, Dept Translat Res & Cellular Therapeut, Duarte, CA 91010 USA.
   [Shuck, Sarah C.] City Hope Natl Med Ctr, Arthur Riggs Diabet & Metab Res Inst, Beckman Res Inst, Dept Diabet & Canc Metab, Duarte, CA 91010 USA.
C3 Shanghai University of Traditional Chinese Medicine; Shanghai University
   of Traditional Chinese Medicine; City of Hope; Beckman Research
   Institute of City of Hope; City of Hope; City of Hope; Beckman Research
   Institute of City of Hope; City of Hope; Beckman Research Institute of
   City of Hope
RP Yang, L (通讯作者)，Shanghai Univ Tradit Chinese Med, Inst Chinese Mat Med, Shanghai Key Lab Compound Chinese Med, Shanghai, Peoples R China.; Yang, L (通讯作者)，Shanghai Univ Tradit Chinese Med, Inst Chinese Mat Med, Minist Educ MOE Key Lab Standardizat Chinese Med, Shanghai, Peoples R China.; Huang, WD (通讯作者)，City Hope Natl Med Ctr, Beckman Res Inst, Dept Diabet Complicat & Metab, Arthur Riggs Diabet & Metab Res Inst, Duarte, CA 91010 USA.; Huang, WD (通讯作者)，City Hope Natl Med Ctr, Irell & Manella Grad Sch Biol Sci, 1500 E Duarte Rd, Duarte, CA 91010 USA.
EM yl7@shutcm.edu.cn; whuang@coh.org
RI Wang, Zhengtao/AAH-7360-2019; Fan, Mingjie/GZM-9365-2022; Fang,
   Zhipeng/HMW-1650-2023
OI Wang, Zhengtao/0000-0003-2797-4625; Zhang, Eryun/0000-0003-3862-3839;
   Natarajan, Rama/0000-0003-4494-1788; Fang, Zhipeng/0000-0001-5720-1709
FU George & Irina Schaeffer Foundation; John C. Hench Foundation; COH-UCR
   Biomedical Research Initiative; AR-DMRI Pilot Grant; Caltech-COH
   Biomedical Research Initiative; National Institutes of Health
   [R01CA139158, R01DK124627, COH P30CA33572]; National Natural Science
   Foundation of China [81573581, 8192010803]
FX We thank Dr. Fouad Kandeel, Dr. Debbie Thurmond, Dr. Sarah Highlander,
   and Dr. Qiong (Annabel) Wang for their helpful discussions. We
   particularly thank Dr. Kerin Higa for reviewing and editing the
   manuscript. This study was supported in part by the George & Irina
   Schaeffer Foundation, the John C. Hench Foundation, COH-UCR Biomedical
   Research Initiative, AR-DMRI Pilot Grant, Caltech-COH Biomedical
   Research Initiative, the National Institutes of Health (grants
   R01CA139158 and R01DK124627 to W.H. and COH P30CA33572), the National
   Natural Science Foundation of China (grants 81573581 to L.Y. and
   8192010803 to Z.W.).
CR Ageitos JM, 2017, BIOCHEM PHARMACOL, V133, P117, DOI 10.1016/j.bcp.2016.09.018
   Bailey CJ, 2008, DIABETOLOGIA, V51, P1552, DOI 10.1007/s00125-008-1053-5
   Barengolts E, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0194171
   Bauer PV, 2018, CELL METAB, V27, P101, DOI 10.1016/j.cmet.2017.09.019
   Booth IR, 2003, BIOCHEM SOC T, V31, P1406
   Bornstein S, 2017, ENDOCRINOLOGY, V158, P3369, DOI 10.1210/en.2017-00299
   Breining P, 2018, DIABETES OBES METAB, V20, P2264, DOI 10.1111/dom.13362
   Bryrup T, 2019, DIABETOLOGIA, V62, P1024, DOI 10.1007/s00125-019-4848-7
   Buse JB, 2016, DIABETES CARE, V39, P198, DOI 10.2337/dc15-0488
   Canfora EE, 2019, NAT REV ENDOCRINOL, V15, P261, DOI 10.1038/s41574-019-0156-z
   Cash HL, 2006, SCIENCE, V313, P1126, DOI 10.1126/science.1127119
   Chen C, 2018, FOOD FUNCT, V9, P3732, DOI [10.1039/C7FO01346A, 10.1039/c7fo01346a]
   Chevalier C, 2015, CELL, V163, P1360, DOI 10.1016/j.cell.2015.11.004
   Cote CD, 2015, NAT MED, V21, P498, DOI 10.1038/nm.3821
   Cui HX, 2019, FRONT MICROBIOL, V10, DOI 10.3389/fmicb.2019.01423
   Desjardins EM, 2018, CURR DIABETES REP, V18, DOI 10.1007/s11892-018-1049-6
   Ding. L., 2016, SCI REP-UK, V6
   Duca FA, 2015, CELL METAB, V22, P367, DOI 10.1016/j.cmet.2015.07.003
   Duca FA, 2015, NAT MED, V21, P506, DOI 10.1038/nm.3787
   Elbere I, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0204317
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Fullerton MD, 2013, NAT MED, V19, P1649, DOI 10.1038/nm.3372
   Hardie DG, 2006, PHYSIOLOGY, V21, P48, DOI 10.1152/physiol.00044.2005
   Harmel E, 2014, ENDOCRINOLOGY, V155, P873, DOI 10.1210/en.2013-1750
   Hernandez JB, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms8216
   Hiel S, 2020, CLIN NUTR, V39, P3618, DOI 10.1016/j.clnu.2020.04.005
   Hu JM, 2016, ENDOCRINOLOGY, V157, P1881, DOI 10.1210/en.2015-1944
   Jackson VM, 2015, EXPERT OPIN DRUG DIS, V10, P825, DOI 10.1517/17460441.2015.1044966
   Ji SQ, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00704
   Jia XM, 2007, MOL CELL BIOCHEM, V306, P133, DOI 10.1007/s11010-007-9563-x
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kim KH, 2018, FRONT PHARMACOL, V9, DOI 10.3389/fphar.2018.01071
   Kuhl C, 2012, ANAL CHEM, V84, P283, DOI 10.1021/ac202450g
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Lee H, 2018, GUT MICROBES, V9, P155, DOI 10.1080/19490976.2017.1405209
   Li BG, 2019, CELL REP, V26, P2720, DOI 10.1016/j.celrep.2019.02.015
   Li Z, 2018, GUT, V67, P1269, DOI 10.1136/gutjnl-2017-314050
   Lin SC, 2018, CELL METAB, V27, P299, DOI 10.1016/j.cmet.2017.10.009
   Liu RX, 2017, NAT MED, V23, P859, DOI 10.1038/nm.4358
   Loonen LMP, 2014, MUCOSAL IMMUNOL, V7, P939, DOI 10.1038/mi.2013.109
   Luo T, 2016, DIABETES, V65, P2295, DOI 10.2337/db15-1122
   Madiraju AK, 2014, NATURE, V510, P542, DOI 10.1038/nature13270
   Mancabelli L, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-10663-w
   Matafome P, 2017, MED RES REV, V37, P368, DOI 10.1002/med.21410
   McCreight LJ, 2016, DIABETOLOGIA, V59, P426, DOI 10.1007/s00125-015-3844-9
   Mills EL, 2018, NATURE, V560, P102, DOI 10.1038/s41586-018-0353-2
   Moraru A, 2018, CELL METAB, V27, P926, DOI 10.1016/j.cmet.2018.02.003
   Prince JT, 2006, ANAL CHEM, V78, P6140, DOI 10.1021/ac0605344
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Rabbani N, 2014, NAT PROTOC, V9, P1969, DOI 10.1038/nprot.2014.129
   Rena G, 2017, DIABETOLOGIA, V60, P1577, DOI 10.1007/s00125-017-4342-z
   Ryan PM, 2020, CAN J DIABETES, V44, P146, DOI 10.1016/j.jcjd.2019.05.008
   Sakar Y, 2010, J PHYSIOL PHARMACOL, V61, P301
   Shaw RJ, 2005, SCIENCE, V310, P1642, DOI 10.1126/science.1120781
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Smith BK, 2016, AM J PHYSIOL-ENDOC M, V311, pE730, DOI 10.1152/ajpendo.00225.2016
   Steinberg GR, 2019, NAT REV DRUG DISCOV, V18, P527, DOI 10.1038/s41573-019-0019-2
   Stepensky D, 2002, DRUG METAB DISPOS, V30, P861, DOI 10.1124/dmd.30.8.861
   Sun XF, 2017, CELL DEATH DIFFER, V24, P819, DOI 10.1038/cdd.2017.14
   Tautenhahn R., 2008, BMC BIOINFORMATICS, V9
   Tong XL, 2018, MBIO, V9, DOI 10.1128/mBio.02392-17
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   van Dam AD, 2015, TRENDS MOL MED, V21, P571, DOI 10.1016/j.molmed.2015.07.003
   Walker J, 2005, BIOCHEM J, V385, P485, DOI 10.1042/BJ20040694
   Woods A, 2003, CURR BIOL, V13, P2004, DOI 10.1016/j.cub.2003.10.031
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Yang QY, 2016, CELL METAB, V24, P542, DOI 10.1016/j.cmet.2016.08.010
   Yuan T, 2019, DIABETOL METAB SYNDR, V11, DOI 10.1186/s13098-019-0490-2
   Zhang XC, 2015, SCI REP-UK, V5, DOI 10.1038/srep11369
   Zhou GC, 2001, J CLIN INVEST, V108, P1167, DOI 10.1172/JCI200113505
NR 70
TC 8
Z9 8
U1 14
U2 40
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
EI 2041-1723
J9 NAT COMMUN
JI Nat. Commun.
PD MAR 3
PY 2022
VL 13
IS 1
AR 1135
DI 10.1038/s41467-022-28743-5
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA ZM3JM
UT WOS:000764258100006
PM 35241650
OA Green Published, Green Submitted, gold
DA 2023-06-08
ER

PT J
AU Hiel, S
   Gianfrancesco, MA
   Rodriguez, J
   Portheault, D
   Leyrolle, Q
   Bindels, LB
   Cauduro, CGD
   Mulders, MDGH
   Zamariola, G
   Azzi, AS
   Kalala, G
   Pachikian, BD
   Amadieu, C
   Neyrinck, AM
   Loumaye, A
   Cani, PD
   Lanthier, N
   Trefois, P
   Klein, O
   Luminet, O
   Bindelle, J
   Paquot, N
   Cnop, M
   Thissen, JP
   Delzenne, NM
AF Hiel, Sophie
   Gianfrancesco, Marco A.
   Rodriguez, Julie
   Portheault, Daphnee
   Leyrolle, Quentin
   Bindels, Laure B.
   Cauduro, Carolina Gomes da Silveira
   Mulders, Maria D. G. H.
   Zamariola, Giorgia
   Azzi, Anne-Sophie
   Kalala, Gaetan
   Pachikian, Barbara D.
   Amadieu, Camille
   Neyrinck, Audrey M.
   Loumaye, Audrey
   Cani, Patrice D.
   Lanthier, Nicolas
   Trefois, Pierre
   Klein, Olivier
   Luminet, Olivier
   Bindelle, Jerome
   Paquot, Nicolas
   Cnop, Miriam
   Thissen, Jean-Paul
   Delzenne, Nathalie M.
TI Link between gut microbiota and health outcomes in inulin -treated obese
   patients: Lessons from the Food4Gut multicenter randomized
   placebo-controlled trial
SO CLINICAL NUTRITION
LA English
DT Article
DE Microbiota; Prebiotics; Obesity; Metformin; Inulin
ID DOUBLE-BLIND; WEIGHT-LOSS; OLIGOFRUCTOSE; SUPPLEMENTATION;
   QUESTIONNAIRE; OVERWEIGHT; BEHAVIOR; ADULTS; DIET
AB Background: The gut microbiota is altered in obesity and is strongly influenced by nutrients and xenobiotics. We have tested the impact of native inulin as prebiotic present in vegetables and added as a supplement on gut microbiota-related outcomes in obese patients. Metformin treatment was analyzed as a potential modulator of the response.
   Methods: A randomized, single-blinded, multicentric, placebo-controlled trial was conducted in 150 obese patients who received 16 g/d native inulin versus maltodextrin, coupled to dietary advice to consume inulin-rich versus-poor vegetables for 3 months, respectively, in addition to dietary caloric restriction. Anthropometry, diagnostic imaging (abdominal CT-scan, fibroscan), food-behavior questionnaires, serum biology and fecal microbiome (primary outcome; 16S rDNA sequencing) were analyzed before and after the intervention.
   Results: Both placebo and prebiotic interventions lowered energy intake, BMI, systolic blood pressure, and serum gamma-GT. The prebiotic induced greater weight loss and additionally decreased diastolic blood pressure, AST and insulinemia. Metformin treatment compromised most of the gut microbiota changes and metabolic improvements linked to prebiotic intervention. The prebiotic modulated specific bacteria, associated with the improvement of anthropometry (i.e. a decrease in Desulfovibrio and Clostridium sensu stricto). A large increase in Bifidobacterium appears as a signature of inulin intake rather than a driver of prebiotic-linked biological outcomes.
   Conclusions: Inulin-enriched diet is able to promote weight loss in obese patients, the treatment efficiency being related to gut microbiota characteristics. This treatment is more efficacious in patients who did not receive metformin as anti-diabetic drugs prior the intervention, supporting that both drug treatment and microbiota might be takYen into account in personalized nutrition interventions. (C) 2020 The Authors. Published by Elsevier Ltd.
C1 [Hiel, Sophie; Rodriguez, Julie; Leyrolle, Quentin; Bindels, Laure B.; Amadieu, Camille; Neyrinck, Audrey M.; Cani, Patrice D.; Delzenne, Nathalie M.] Catholic Univ Louvain, Louvain Drug Res Inst, Metab & Nutr Res Grp, UCLouvain, Ave E Mounier Box B1-73-11, B-1200 Brussels, Belgium.
   [Gianfrancesco, Marco A.; Paquot, Nicolas] Univ Liege, Lab Diabetol Nutr & Metab Dis, Liege, Belgium.
   [Portheault, Daphnee; Cauduro, Carolina Gomes da Silveira; Cnop, Miriam] Univ Libre Bruxelles, ULB Ctr Diabet Res, Brussels, Belgium.
   [Mulders, Maria D. G. H.; Klein, Olivier] Univ Libre Bruxelles, Ctr Social & Cultural Psychol, Brussels, Belgium.
   [Zamariola, Giorgia; Luminet, Olivier] Catholic Univ Louvain, Res Inst Psychol Sci, UCLouvain, Louvain La Neuve, Belgium.
   [Azzi, Anne-Sophie; Cnop, Miriam] Univ Libre Bruxelles, Erasmus Hosp, Div Endocrinol, Brussels, Belgium.
   [Kalala, Gaetan; Bindelle, Jerome] Univ Liege, Gembloux Agrobio Tech, Gembloux, Belgium.
   [Pachikian, Barbara D.] Catholic Univ Louvain, Ctr Invest Clin Nutr, Louvain La Neuve, Belgium.
   [Loumaye, Audrey; Thissen, Jean-Paul] Catholic Univ Louvain, UCLouvain, Inst Rech Expt & Clin, Pole Endocrinol Diabet & Nutr, Brussels, Belgium.
   [Cani, Patrice D.] Catholic Univ Louvain, UCLouvain, WELBIO Walloon Excellence Life Sci & BIOtechnol, Brussels, Belgium.
   [Lanthier, Nicolas] Catholic Univ Louvain, UCLouvain, Inst Rech Expt & Clin, Lab Hepatogastroenterol, Brussels, Belgium.
   [Trefois, Pierre] Clin Univ St Luc, Dept Med Imaging, Brussels, Belgium.
C3 Universite Catholique Louvain; University of Liege; Universite Libre de
   Bruxelles; Universite Libre de Bruxelles; Universite Catholique Louvain;
   Universite Libre de Bruxelles; University of Liege; Universite
   Catholique Louvain; Universite Catholique Louvain; Universite Catholique
   Louvain; WELBIO; Universite Catholique Louvain; Universite Catholique
   Louvain; Cliniques Universitaires Saint-Luc
RP Delzenne, NM (通讯作者)，Catholic Univ Louvain, Louvain Drug Res Inst, Metab & Nutr Res Grp, UCLouvain, Ave E Mounier Box B1-73-11, B-1200 Brussels, Belgium.
EM nathalie.delzenne@uclouvain.be
RI Lanthier, Nicolas/AAT-2930-2021; Bindels, Laure/T-7846-2019; D., Cani
   Patrice/M-8055-2016; LEYROLLE, Quentin/GZG-7491-2022; Rodriguez,
   Julie/AAM-7813-2020; Gomes da Silveira Cauduro, Carolina/E-6853-2017
OI Lanthier, Nicolas/0000-0002-7651-9314; Bindels,
   Laure/0000-0003-3747-3234; D., Cani Patrice/0000-0003-2040-2448; Azzi,
   Anne-Sophie/0000-0001-8556-9236; Mulders, Maria/0000-0001-7012-5640;
   Rodriguez, Julie/0000-0002-8271-3893; Cnop, Miriam/0000-0002-5112-1692;
   Amadieu, Camille/0000-0003-3359-9315; Gomes da Silveira Cauduro,
   Carolina/0000-0001-7054-9910; Leyrolle, Quentin/0000-0002-0763-1433
FU Walloon competitive cluster [1318148]; Walloon competitive cluster
   (FOOD4GUT project) [1318148]; Wallonia (FiberTAG project from European
   Joint Programming Initiative "A Healthy Diet for a Healthy Life");
   Belgium National Scientific Research Fund (FRS-FNRS, convention
   [PINT-MULTI R.8013.19, PDR T.0068.19]; UCLouvain (Action de Recherche
   Concertee) [ARC18-23/092]; FRS-FNRS; Excellence Of Science
   [WELBIO-CR-2017-C02, EOS 30770923]; Funds Baillet Latour Grant for
   Medical Research
FX This study was funded by the Walloon competitive cluster (FOOD4GUT
   project, convention 1318148). NMD is a recipient of other grant from
   Wallonia (FiberTAG project from European Joint Programming Initiative "A
   Healthy Diet for a Healthy Life"), from Belgium National Scientific
   Research Fund (FRS-FNRS, convention PINT-MULTI R.8013.19 (NEURON, call
   2019) and convention PDR T.0068.19) and from UCLouvain (Action de
   Recherche Concertee ARC18-23/092). OL is a Research Director from the
   FRS-FNRS. PDC is senior research associate from the FRS-FNRS and has
   grants (WELBIO-CR-2017-C02, The Excellence Of Science: EOS 30770923) and
   is a recipient of the Funds Baillet Latour Grant for Medical Research
   2015. The funders had no role in study design, data collection and
   analysis, decision to publish, or preparation of the manuscript.
CR Afshin A, 2017, NEW ENGL J MED, V377, P13, DOI 10.1056/NEJMoa1614362
   Agostoni C, 2010, EFSA J, V8, DOI 10.2903/j.efsa.2010.1462
   Bailly N, 2012, APPETITE, V59, P853, DOI 10.1016/j.appet.2012.08.029
   Cani PD, 2005, OBES RES, V13, P1000, DOI 10.1038/oby.2005.117
   Chambers ES, 2019, GUT, V68, P1430, DOI 10.1136/gutjnl-2019-318424
   Costabile A, 2010, BRIT J NUTR, V104, P1007, DOI 10.1017/S0007114510001571
   Daubioul CA, 2005, EUR J CLIN NUTR, V59, P723, DOI 10.1038/sj.ejcn.1602127
   Daud NM, 2014, OBESITY, V22, P1430, DOI 10.1002/oby.20754
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   de Luis DA, 2013, NUTR HOSP, V28, P78, DOI 10.3305/nh.2013.28.1.6255
   Delzenne NM, 2013, BRIT J NUTR, V109, pS81, DOI 10.1017/S0007114512004047
   Dewulf EM, 2013, GUT, V62, P1112, DOI 10.1136/gutjnl-2012-303304
   Falony G, 2006, APPL ENVIRON MICROB, V72, P7835, DOI 10.1128/AEM.01296-06
   Farhangi MA, 2016, PRIM CARE DIABETES, V10, P265, DOI 10.1016/j.pcd.2015.10.009
   Forouhi NG, 2019, LANCET, V393, P1916, DOI 10.1016/S0140-6736(19)30500-8
   Garcia-Mantrana I, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.00890
   Gibson GR, 2017, NAT REV GASTRO HEPAT, V14, P491, DOI 10.1038/nrgastro.2017.75
   Hiel S, 2019, AM J CLIN NUTR, V109, P1683, DOI 10.1093/ajcn/nqz001
   Holscher HD, 2015, J NUTR, V145, P2025, DOI 10.3945/jn.115.217331
   Kalala G, 2018, INT J FOOD SCI NUTR, V69, P682, DOI 10.1080/09637486.2017.1412404
   Le Bastard Q, 2020, EUR J CLIN MICROBIOL, V39, P403, DOI 10.1007/s10096-019-03721-w
   Mintz LB, 1997, J COUNS PSYCHOL, V44, P63, DOI 10.1037/0022-0167.44.1.63
   Nicolucci AC, 2017, GASTROENTEROLOGY, V153, P711, DOI 10.1053/j.gastro.2017.05.055
   Olivares M, 2018, DIABETOLOGIA, V61, P1838, DOI 10.1007/s00125-018-4647-6
   Parnell JA, 2009, AM J CLIN NUTR, V89, P1751, DOI 10.3945/ajcn.2009.27465
   Pol K, 2018, BRIT J NUTR, V119, P1076, DOI [10.1017/S0007114518000211, 10.1017/s0007114518000211]
   Potgens SA, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-30569-5
   Ramnani P, 2015, J NUTR SCI, V4, DOI 10.1017/jns.2014.68
   Reimer RA, 2017, MOL NUTR FOOD RES, V61, DOI 10.1002/mnfr.201700484
   Rodriguez J, 2018, CURR OPIN CLIN NUTR, V21, P294, DOI 10.1097/MCO.0000000000000468
   Slavin J, 2011, FOOD FUNCT, V2, P72, DOI 10.1039/c0fo00101e
   Sun SS, 2003, AM J CLIN NUTR, V77, P331, DOI 10.1093/ajcn/77.2.331
   TUSCHL RJ, 1990, APPETITE, V14, P105, DOI 10.1016/0195-6663(90)90004-R
   Vandeputte D, 2017, GUT, V66, P1968, DOI 10.1136/gutjnl-2016-313271
   Vilar-Gomez E, 2015, GASTROENTEROLOGY, V149, P367, DOI 10.1053/j.gastro.2015.04.005
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Yan H, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0059581
   Yun Y, 2017, BMC MICROBIOL, V17, DOI 10.1186/s12866-017-1052-0
   Zeng Q, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-49462-w
   Zmora N, 2019, NAT REV GASTRO HEPAT, V16, P35, DOI 10.1038/s41575-018-0061-2
NR 40
TC 51
Z9 52
U1 2
U2 20
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0261-5614
EI 1532-1983
J9 CLIN NUTR
JI Clin. Nutr.
PD DEC
PY 2020
VL 39
IS 12
BP 3618
EP 3628
DI 10.1016/j.clnu.2020.04.005
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA PH6YQ
UT WOS:000600555900007
PM 32340903
OA hybrid, Green Published
DA 2023-06-08
ER

PT J
AU de la Cuesta-Zuluaga, J
   Mueller, NT
   Corrales-Agudelo, V
   Velasquez-Mejia, EP
   Carmona, JA
   Abad, JM
   Escobar, JS
AF de la Cuesta-Zuluaga, Jacobo
   Mueller, Noel T.
   Corrales-Agudelo, Vanessa
   Velasquez-Mejia, Eliana P.
   Carmona, Jenny A.
   Abad, Jose M.
   Escobar, Juan S.
TI Metformin Is Associated With Higher Relative Abundance of
   Mucin-Degrading Akkermansia muciniphila and Several Short-Chain Fatty
   Acid-Producing Microbiota in the Gut
SO DIABETES CARE
LA English
DT Article
ID DIET-INDUCED OBESITY; METABOLISM; METAGENOME; CROSSTALK; BUTYRATE;
   GLUCAGON; DIFFERS; GLUCOSE; ADULTS; DRUG
AB OBJECTIVE
   Recent studies suggest the beneficial effects of metformin on glucose metabolism may be microbially mediated. We examined the association of type 2 diabetes, metformin, and gut microbiota in community-dwelling Colombian adults. On the basis of previous research, we hypothesized that metformin is associated with higher levels of short-chain fatty acid (SCFA)-producing and mucin-degrading microbiota.
   RESEARCH DESIGN AND METHODS
   Participants were selected from a larger cohort of 459 participants. The present analyses focus on the 28 participants diagnosed with diabetes-14 taking metformin- and the 84 participants without diabetes who were matched (3-to-1) to participants with diabetes by sex, age, and BMI. We measured demographic information, anthropometry, and blood biochemical parameters and collected fecal samples from which we performed 16S rRNA gene sequencing to analyze the composition and structure of the gut microbiota.
   RESULTS
   We found an association between diabetes and gut microbiota that was modified by metformin use. Compared with participants without diabetes, participants with diabetes taking metformin had higher relative abundance of Akkermansia muciniphila, a microbiota known for mucin degradation, and several gut microbiota known for production of SCFAs, including Butyrivibrio, Bifidobacterium bifidum, Megasphaera, and an operational taxonomic unit of Prevotella. In contrast, compared with participants without diabetes, participants with diabetes not taking metformin had higher relative abundance of Clostridiaceae 02d06 and a distinct operational taxonomic unit of Prevotella and a lower abundance of Enterococcus casseliflavus.
   CONCLUSIONS
   Our results support the hypothesis that metformin shifts gut microbiota composition through the enrichment of mucin-degrading A. muciniphila as well as several SCFA-producing microbiota. Future studies are needed to determine if these shifts mediate metformin's glycemic and anti-inflammatory properties.
C1 [de la Cuesta-Zuluaga, Jacobo; Corrales-Agudelo, Vanessa; Velasquez-Mejia, Eliana P.; Escobar, Juan S.] Grp Empresarial Nutresa, Vidarium Nutr Hlth & Wellness Res Ctr, Medellin, Colombia.
   [Mueller, Noel T.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA.
   [Carmona, Jenny A.] Dinam IPS Especialista Ayudas Diagnost, Medellin, Colombia.
   [Abad, Jose M.] EPS & Med Prepagada Suramer SA, Medellin, Colombia.
C3 Johns Hopkins University; Johns Hopkins Bloomberg School of Public
   Health
RP Escobar, JS (通讯作者)，Grp Empresarial Nutresa, Vidarium Nutr Hlth & Wellness Res Ctr, Medellin, Colombia.
EM jsescobar@serviciosnutresa.com
RI Escobar, Juan S/F-7234-2013
OI Escobar, Juan S/0000-0001-7304-917X; de la Cuesta-Zuluaga, Juan
   Jacobo/0000-0002-7369-992X; Mueller, Noel/0000-0002-7412-8352
FU Grupo Empresarial Nutresa; EPS SURA; Dinamica I.P.S.
FX This work was funded by Grupo Empresarial Nutresa, EPS SURA, and
   Dinamica I.P.S.
CR Bailey CJ, 2008, DIABETOLOGIA, V51, P1552, DOI 10.1007/s00125-008-1053-5
   BONORA E, 1984, CURR MED RES OPIN, V9, P47, DOI 10.1185/03007998409109558
   Buse JB, 2016, DIABETES CARE, V39, P198, DOI 10.2337/dc15-0488
   Cabreiro F, 2013, CELL, V153, P228, DOI 10.1016/j.cell.2013.02.035
   Chen J, 2012, BIOINFORMATICS, V28, P2106, DOI 10.1093/bioinformatics/bts342
   De Vadder F, 2014, CELL, V156, P84, DOI 10.1016/j.cell.2013.12.016
   Escobar JS, 2014, BMC MICROBIOL, V14, DOI 10.1186/s12866-014-0311-6
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Fukuda S, 2011, NATURE, V469, P543, DOI 10.1038/nature09646
   Gargari G, 2016, APPL ENVIRON MICROB, V82, P5850, DOI 10.1128/AEM.01753-16
   Hamer HM, 2008, ALIMENT PHARM THER, V27, P104, DOI 10.1111/j.1365-2036.2007.03562.x
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kelly CJ, 2015, CELL HOST MICROBE, V17, P662, DOI 10.1016/j.chom.2015.03.005
   Kozich JJ, 2013, APPL ENVIRON MICROB, V79, P5112, DOI 10.1128/AEM.01043-13
   Lamanna C, 2011, DIABETES OBES METAB, V13, P221, DOI 10.1111/j.1463-1326.2010.01349.x
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Machiels Kathleen, 2014, Gut, V63, P1275, DOI 10.1136/gutjnl-2013-304833
   Maida A, 2011, DIABETOLOGIA, V54, P339, DOI 10.1007/s00125-010-1937-z
   Mannucci E, 2001, DIABETES CARE, V24, P489, DOI 10.2337/diacare.24.3.489
   Murray BE, 2000, NEW ENGL J MED, V342, P710, DOI 10.1056/NEJM200003093421007
   Napolitano A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100778
   Oksanen J., 2016, VEGAN COMMUNITY ECOL, DOI [10.1186/s12866-016-0748-x, DOI 10.1186/S12866-016-0748-X]
   Pernicova I, 2014, NAT REV ENDOCRINOL, V10, P143, DOI 10.1038/nrendo.2013.256
   Pryor R, 2015, BIOCHEM J, V471, P307, DOI 10.1042/BJ20150497
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   R Development Core Team, 2012, R LANG ENV STAT COMP
   Rena G, 2013, DIABETOLOGIA, V56, P1898, DOI 10.1007/s00125-013-2991-0
   Schloss PD, 2009, APPL ENVIRON MICROB, V75, P7537, DOI 10.1128/AEM.01541-09
   Segata N, 2011, GENOME BIOL, V12, DOI 10.1186/gb-2011-12-6-r60
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Sokol H, 2009, INFLAMM BOWEL DIS, V15, P1183, DOI 10.1002/ibd.20903
   Storey J. D., 2015, QVALUE Q VALUE ESTIM
   Turroni F, 2010, P NATL ACAD SCI USA, V107, P19514, DOI 10.1073/pnas.1011100107
   Wahlstrom A, 2008, INT J SYST EVOL MICR, V58, P970
   Wahlstrom A, 2016, CELL METAB, V24, P41, DOI 10.1016/j.cmet.2016.05.005
   Wu GD, 2011, SCIENCE, V334, P105, DOI 10.1126/science.1208344
   Zhang XY, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0071108
   Zhang X, 2015, SCI REP-UK, V5, DOI 10.1038/srep14405
NR 40
TC 392
Z9 402
U1 8
U2 128
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0149-5992
EI 1935-5548
J9 DIABETES CARE
JI Diabetes Care
PD JAN
PY 2017
VL 40
IS 1
BP 54
EP 62
DI 10.2337/dc16-1324
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EG2BA
UT WOS:000390846100011
PM 27999002
OA Bronze
HC Y
HP N
DA 2023-06-08
ER

PT J
AU Bi, RH
   Gao, J
   Pan, L
   Lai, XR
AF Bi, Ruohong
   Gao, Jie
   Pan, Lin
   Lai, Xianrong
TI Progress in the Treatment of Diabetes Mellitus Based on Intestinal Flora
   Homeostasis and the Advancement of Holistic Analysis Methods
SO NATURAL PRODUCT COMMUNICATIONS
LA English
DT Review
DE diabetes mellitus; holistic view; intestinal flora; mechanism; host
   metabolism; metabonomics
ID GUT MICROBIOTA; AKKERMANSIA-MUCINIPHILA; METFORMIN ALTERS; OBESITY;
   BACTERIA; IMPACT; MICROFLORA; MECHANISMS; PREVENTION; INCREASES
AB Diabetes mellitus (DM) is a complex metabolic disorder characterized by abnormal glucose metabolism, which is accompanied by alterations in energy metabolism, intestinal bacterial metabolism, amino acid metabolism, lipid metabolism, nucleotide metabolism, and others. However, intestinal flora metabolism plays a fundamental role in host metabolism; they are complementary to each other and help maintain homeostasis, thus ensuring the normal operation of the host metabolic system. This suggests that a holistic analysis method would be of great use in the study of the overall metabolism in patients with DM. With this in mind, this review summarizes the mechanism of intestinal flora metabolism regarding the occurrence of DM and assesses the effects of drug treatments on the intestinal flora of patients with diabetes. Based on these results, we combined intestinal flora metabolism with host metabolism to evaluate the necessity and the advantages of holistic metabonomics analyses in the treatment of DM and its complications.
C1 [Bi, Ruohong; Gao, Jie; Pan, Lin; Lai, Xianrong] Chengdu Univ Tradit Chinese Med, Sch Pharm, Chengdu, Peoples R China.
   [Lai, Xianrong] Chengdu Univ Tradit Chinese Med, Sch Ethn Med, 1166 Liutai Ave, Chengdu 11137, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine; Chengdu University
   of Traditional Chinese Medicine
RP Lai, XR (通讯作者)，Chengdu Univ Tradit Chinese Med, Sch Ethn Med, 1166 Liutai Ave, Chengdu 11137, Peoples R China.
EM vegf@bcdutcm.edu.cn
FU National Natural Science Foundation of China [81774007, 81560806,
   81473427, 81173360]; National Key R&D Program of China [2017YFC1703904];
   Science and Technology Plan of Qinghai Province; Education Department of
   Sichuan Province [16ZA0120]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This paper
   was fully funded by the National Natural Science Foundation of China
   (Nos. 81774007, 81560806, 81473427, 81173360), the National Key R&D
   Program of China (No. 2017YFC1703904), the Science and Technology Plan
   of Qinghai Province (2017--ZJ--922Q), and Education Department of
   Sichuan Province (16ZA0120).
CR Ai XP, 2019, J ETHNOPHARMACOL, V241, DOI 10.1016/j.jep.2019.111992
   Al-Aama JY, 2019, DIABETES METAB SYNDR, V12, P2675, DOI 10.2147/DMSO.S215528
   Amar J, 2011, EMBO MOL MED, V3, P559, DOI 10.1002/emmm.201100159
   Atarashi K, 2011, SCIENCE, V331, P337, DOI 10.1126/science.1198469
   Backhed F, 2004, P NATL ACAD SCI USA, V101, P15718, DOI 10.1073/pnas.0407076101
   Backhed F, 2007, P NATL ACAD SCI USA, V104, P979, DOI 10.1073/pnas.0605374104
   Bauer PV, 2018, CELL METAB, V27, P101, DOI 10.1016/j.cmet.2017.09.019
   Bedford A, 2018, ANIM NUTR, V4, P151, DOI 10.1016/j.aninu.2017.08.010
   Beger RD, 2016, METABOLOMICS, V12, DOI 10.1007/s11306-016-1094-6
   Biragyn A, 2018, LANCET ONCOL, V19, pE295, DOI 10.1016/S1470-2045(18)30095-0
   Cani PD, 2007, DIABETOLOGIA, V50, P2374, DOI 10.1007/s00125-007-0791-0
   Chen JP, 2019, FRONT PHARMACOL, V10, DOI 10.3389/fphar.2019.00256
   Chen JH, 2019, J DIABETES RES, V2019, DOI 10.1155/2019/3705264
   Chen MY, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.02380
   Colombo M, 2020, DIABETOLOGIA, V63, P788, DOI 10.1007/s00125-019-05081-8
   Compare D, 2016, DIGEST DIS, V34, P221, DOI 10.1159/000443356
   Creely SJ, 2007, AM J PHYSIOL-ENDOC M, V292, pE740, DOI 10.1152/ajpendo.00302.2006
   De Vadder F, 2016, CELL METAB, V24, P151, DOI 10.1016/j.cmet.2016.06.013
   Del Coco L, 2019, J CLIN MED, V8, DOI 10.3390/jcm8050720
   Durazzo M, 2019, J CLIN MED, V8, DOI 10.3390/jcm8111843
   Ericson U, 2020, J NUTR, V150, P861, DOI 10.1093/jn/nxz293
   Floegel A, 2013, DIABETES, V62, P639, DOI 10.2337/db12-0495
   Forster C, 2008, HISTOCHEM CELL BIOL, V130, P55, DOI 10.1007/s00418-008-0424-9
   Gholizadeh P, 2019, MICROB PATHOGENESIS, V127, P48, DOI 10.1016/j.micpath.2018.11.031
   Gill PA, 2018, ALIMENT PHARM THER, V48, P15, DOI 10.1111/apt.14689
   Halawa MR, 2019, CURR DIABETES REV, V15, P480, DOI 10.2174/1573399815666190206162143
   Han LH, 2019, NUTRIENTS, V11, DOI 10.3390/nu11030670
   Jacouton E, 2017, FRONT IMMUNOL, V8, DOI 10.3389/fimmu.2017.01553
   Knudsen KEB, 2018, NUTRIENTS, V10, DOI 10.3390/nu10101499
   Koh A, 2016, CELL, V165, P1332, DOI 10.1016/j.cell.2016.05.041
   Larsen N., 2017, PLOS ONE, V5
   Lau WL, 2019, NAT REV NEPHROL, V15, P389, DOI 10.1038/s41581-019-0142-7
   Lazar V, 2019, FRONT NUTR, V6, DOI 10.3389/fnut.2019.00021
   Li XW, 2018, MOLECULES, V23, DOI 10.3390/molecules23123245
   Lin GP, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20010025
   Ma QT, 2019, BIOMED PHARMACOTHER, V117, DOI 10.1016/j.biopha.2019.109138
   McNabney SM, 2017, NUTRIENTS, V9, DOI 10.3390/nu9121348
   Mindikoglu AL., 2020, FUTURE SCI OA, V6, DOI [10.2144/fsoa-2019-0124, DOI 10.21444/FSOA-2019-0124]
   Neacsu O, 2013, OBESITY, V21, P1843, DOI 10.1002/oby.20329
   Neu J, 2005, J PEDIATR GASTR NUTR, V40, P589, DOI 10.1097/01.MPG.0000159636.19346.C1
   Nicholson JK, 2012, SCIENCE, V336, P1262, DOI 10.1126/science.1223813
   Odegaard AO, 2016, CARDIOVASC DIABETOL, V15, DOI 10.1186/s12933-016-0369-6
   Pallares-Mendez R, 2016, ANN MED, V48, P89, DOI 10.3109/07853890.2015.1137630
   Pearson ER, 2016, DIABETIC MED, V33, P712, DOI 10.1111/dme.13075
   Peddinti G, 2017, DIABETOLOGIA, V60, P1740, DOI 10.1007/s00125-017-4325-0
   Pedersen HK, 2016, NATURE, V535, P376, DOI 10.1038/nature18646
   Perry RJ, 2016, NATURE, V534, P213, DOI 10.1038/nature18309
   Petriello MC, 2018, ENVIRON POLLUT, V242, P1022, DOI 10.1016/j.envpol.2018.07.039
   Pingitore A, 2017, DIABETES OBES METAB, V19, P257, DOI 10.1111/dom.12811
   Pushpanathan P, 2019, INDIAN J MED MICROBI, V37, P268, DOI 10.4103/ijmm.IJMM_19_373
   Ridlon JM, 2016, GUT MICROBES, V7, P22, DOI 10.1080/19490976.2015.1127483
   Rios-Covian D, 2016, FRONT MICROBIOL, V7, DOI 10.3389/fmicb.2016.00185
   Roopchand DE, 2015, DIABETES, V64, P2847, DOI 10.2337/db14-1916
   Schaap FG, 2014, NAT REV GASTRO HEPAT, V11, P55, DOI 10.1038/nrgastro.2013.151
   Seitz J, 2019, PSYCHIAT CLIN N AM, V42, P93, DOI 10.1016/j.psc.2018.10.004
   Shaikh A, 2020, EXCLI J, V19, P33, DOI 10.17179/excli2019-1441
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Singer-Englar T, 2019, EXPERT REV GASTROENT, V13, P3, DOI 10.1080/17474124.2019.1543023
   Tavares G, 2018, METABOLOMICS, V14, DOI 10.1007/s11306-018-1337-9
   [田佳星 Tian Jiaxing], 2018, [中国糖尿病杂志, Chinese Journal of Diabetes], V26, P688
   Tong XL, 2018, MBIO, V9, DOI 10.1128/mBio.02392-17
   Tremaroli V, 2012, NATURE, V489, P242, DOI 10.1038/nature11552
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Ussar S, 2016, MOL METAB, V5, P795, DOI 10.1016/j.molmet.2016.07.004
   Ussar S, 2015, CELL METAB, V22, P516, DOI 10.1016/j.cmet.2015.07.007
   Wahlstrom A, 2016, CELL METAB, V24, P41, DOI 10.1016/j.cmet.2016.05.005
   Wang CY, 2016, PHARM BIOL, V54, P3086, DOI 10.1080/13880209.2016.1211153
   Wang NN, 2018, LIFE SCI, V212, P194, DOI 10.1016/j.lfs.2018.09.035
   Wei XY, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-22094-2
   Woldeamlak Birhanu, 2019, Korean J Gastroenterol, V74, P314, DOI 10.4166/kjg.2019.74.6.314
   Woting A, 2016, NUTRIENTS, V8, DOI 10.3390/nu8040202
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Wu R, 2019, FRONT PHYSIOL, V10, DOI 10.3389/fphys.2019.00918
   Xie YQ, 2018, J DIABETES RES, V2018, DOI 10.1155/2018/4230590
   Yan FF, 2019, FOOD FUNCT, V10, P5804, DOI 10.1039/c9fo01062a
   Yan X, 2019, J FOOD SCI, V84, P165, DOI 10.1111/1750-3841.14415
   Yang P, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/9570616
   Yi L, 2018, TRANSL RES, V201, P13, DOI 10.1016/j.trsl.2018.07.009
   Zhang ZY, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00640
   Zhao LJ, 2019, ENDOCRINE, V66, P526, DOI 10.1007/s12020-019-02103-8
   Zhao LP, 2018, SCIENCE, V359, P1151, DOI 10.1126/science.aao5774
   Zhou JC, 2019, CHIN J NAT MEDICINES, V17, P835, DOI 10.1016/S1875-5364(19)30101-3
   Zimmermann M, 2019, NATURE, V570, P462, DOI 10.1038/s41586-019-1291-3
   Zubair KU, 2019, PAK J MED SCI, V35, P1664, DOI 10.12669/pjms.35.6.115
NR 84
TC 1
Z9 1
U1 15
U2 55
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1934-578X
EI 1555-9475
J9 NAT PROD COMMUN
JI Nat. Prod. Commun.
PD APR
PY 2020
VL 15
IS 4
DI 10.1177/1934578X20918418
PG 11
WC Chemistry, Medicinal; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Food Science & Technology
GA LO7WF
UT WOS:000533837400001
OA gold
DA 2023-06-08
ER

PT J
AU Koh, A
   Manneras-Holm, L
   Yunn, NO
   Nilsson, PM
   Ryu, SH
   Molinaro, A
   Perkins, R
   Smith, JG
   Backhed, F
AF Koh, Ara
   Manneras-Holm, Louise
   Yunn, Na-Oh
   Nilsson, Peter M.
   Ryu, Sung Ho
   Molinaro, Antonio
   Perkins, Rosie
   Smith, J. Gustav
   Backhed, Fredrik
TI Microbial Imidazole Propionate Affects Responses to Metformin through
   p38 gamma-Dependent Inhibitory AMPK Phosphorylation
SO CELL METABOLISM
LA English
DT Article
ID ACTIVATED PROTEIN-KINASE; SKELETAL-MUSCLE; INSULIN-RESISTANCE; AKT;
   SULFASALAZINE; INACTIVATION; CHEMOTHERAPY; INCREASES; MECHANISM; MTORC1
AB Metformin is the first-line therapy for type 2 diabetes, but there are large inter-individual variations in responses to this drug. Its mechanism of action is not fully understood, but activation of AMP-activated protein kinase (AMPK) and changes in the gut microbiota appear to be important. The inhibitory role of microbial metabolites on metformin action has not previously been investigated. Here, we show that concentrations of the microbial metabolite imidazole propionate are higher in subjects with type 2 diabetes taking metformin who have high blood glucose. We also show that metformin-induced glucose lowering is not observed in mice pretreated with imidazole propionate. Furthermore, we demonstrate that imidazole propionate inhibits AMPK activity by inducing inhibitory AMPK phosphorylation, which is dependent on imidazole propionate-induced basal Akt activation. Finally, we identify imidazole propionate-activated p38 gamma as a novel kinase for Akt and demonstrate that p38 gamma kinase activity mediates the inhibitory action of imidazole propionate on metformin.
C1 [Koh, Ara] Sungkyunkwan Univ SKKU, Samsung Med Ctr, Sch Med, Samsung Biomed Res Inst,Dept Precis Med, Suwon 16419, South Korea.
   [Koh, Ara; Manneras-Holm, Louise; Molinaro, Antonio; Perkins, Rosie; Smith, J. Gustav; Backhed, Fredrik] Univ Gothenburg, Inst Med, Wallenberg Lab, Dept Mol & Clin Med, Gothenburg, Sweden.
   [Koh, Ara; Manneras-Holm, Louise; Molinaro, Antonio; Perkins, Rosie; Smith, J. Gustav; Backhed, Fredrik] Sahlgrens Univ Hosp, Gothenburg, Sweden.
   [Yunn, Na-Oh; Ryu, Sung Ho] Pohang Univ Sci & Technol, Dept Life Sci, Pohang, South Korea.
   [Nilsson, Peter M.] Lund Univ, Dept Internal Med, Clin Sci, Malmo, Sweden.
   [Smith, J. Gustav] Lund Univ, Dept Cardiol, Clin Sci, Lund, Sweden.
   [Smith, J. Gustav] Skane Univ Hosp, Lund, Sweden.
   [Smith, J. Gustav] Lund Univ, Wallenberg Ctr Mol Med, Lund, Sweden.
   [Smith, J. Gustav] Lund Univ, Diabet Ctr, Lund, Sweden.
   [Backhed, Fredrik] Univ Copenhagen, Fac Hlth Sci, Sect Metab Receptol & Enteroendocrinol, Novo Nordisk Fdn,Ctr Basic Metab Res, Copenhagen, Denmark.
   [Backhed, Fredrik] Sahlgrens Univ Hosp, Dept Clin Physiol, Reg Vastra Gotaland, Gothenburg, Sweden.
C3 Sungkyunkwan University (SKKU); Samsung Medical Center; University of
   Gothenburg; Sahlgrenska University Hospital; Pohang University of
   Science & Technology (POSTECH); Lund University; Lund University; Lund
   University; Skane University Hospital; Lund University; Lund University;
   Novo Nordisk Foundation; University of Copenhagen; Sahlgrenska
   University Hospital
RP Koh, A; Backhed, F (通讯作者)，Univ Gothenburg, Inst Med, Wallenberg Lab, Dept Mol & Clin Med, Gothenburg, Sweden.; Koh, A; Backhed, F (通讯作者)，Sahlgrens Univ Hosp, Gothenburg, Sweden.; Backhed, F (通讯作者)，Univ Copenhagen, Fac Hlth Sci, Sect Metab Receptol & Enteroendocrinol, Novo Nordisk Fdn,Ctr Basic Metab Res, Copenhagen, Denmark.; Backhed, F (通讯作者)，Sahlgrens Univ Hosp, Dept Clin Physiol, Reg Vastra Gotaland, Gothenburg, Sweden.
EM arakoh@skku.edu; fredrik@wlab.gu.se
RI Backhed, Fredrik/ABE-6613-2020
OI Backhed, Fredrik/0000-0002-4871-8818; Koh, Ara/0000-0001-7673-034X;
   Yunn, Na-Oh/0000-0002-0675-4183
FU Swedish Research Council [2013-07800, 2017-02554, 349-2006237,
   2009-1039]; Novo Nordisk Foundation [NNF19OC0057271, NNF15OC0016798];
   Leducq Foundation [17CVD01]; Swedish government [ALFGBG-718101]; county
   councils, the ALF agreement [ALFGBG-718101]; Swedish Heart-Lung
   Foundation [2016-0134, 2016-0315]; ERC (ERC-STG) [679242]; Skane
   University Hospital; Swedish National Health Service; Swedish Foundation
   for Strategic Research [IRC15-0067]; National Research Foundation of
   Korea (NRF) - Korean government (MSIT) [2020R1C1C1003241]; European
   Research Council (ERC) Consolidator Grant [615362]
FX We thank Oskar Persson, Louise Hellden, and Manuela Kramer for technical
   assistance. We also thank Anna Hallen for producing the graphical
   abstract. This study was supported by the Swedish Research Council
   (2013-07800), the Novo Nordisk Foundation (NNF19OC0057271 and
   NNF15OC0016798), the Leducq Foundation (17CVD01), and grants from the
   Swedish state under the agreement between the Swedish government and the
   county councils, the ALF agreement (ALFGBG-718101). J.G.S. is supported
   by grants from the Swedish Heart-Lung Foundation (2016-0134 and
   2016-0315), the Swedish Research Council (2017-025542017-02554), the ERC
   (ERC-STG-2015-679242), Skane University Hospital, governmental funding
   of clinical research within the Swedish National Health Service, a
   donation from the Knut and Alice Wallenberg Foundation to the Wallenberg
   Center for Molecular Medicine in Lund, and funding from the Swedish
   Research Council (Linnaeus grant Dnr 349-2006237, Strategic Research
   Area Exodiab Dnr 2009-1039) and Swedish Foundation for Strategic
   Research (Dnr IRC15-0067) to the Lund University Diabetes Center. This
   work is also supported by the National Research Foundation of Korea
   (NRF) grant funded by the Korean government (MSIT) (No. 2020R1C1C1003241
   to A.K.). F.B. is a recipient of a European Research Council (ERC)
   Consolidator Grant (615362; METABASE) and is a Wallenberg Scholar and
   Torsten Soderberg Professor in Medicine.
CR Aeder SE, 2004, ONCOGENE, V23, P9062, DOI 10.1038/sj.onc.1208093
   Alessi DR, 1996, EMBO J, V15, P6541, DOI 10.1002/j.1460-2075.1996.tb01045.x
   American Diabetes Association (ADA, 2019, CARE, V42, pS61, DOI [10.2337/dc19-S006, DOI 10.2337/DC19-S006]
   BACHRACH WH, 1988, AM J GASTROENTEROL, V83, P487
   Bentzinger CF, 2008, CELL METAB, V8, P411, DOI 10.1016/j.cmet.2008.10.002
   Brown JB, 2010, DIABETES CARE, V33, P501, DOI 10.2337/dc09-1749
   Chandel NS, 2016, CELL METAB, V23, P569, DOI 10.1016/j.cmet.2016.03.010
   Colebrook L, 1936, LANCET, V2, P1323
   Cook MN, 2005, DIABETES CARE, V28, P995, DOI 10.2337/diacare.28.5.995
   Dagon Y, 2012, CELL METAB, V16, P104, DOI 10.1016/j.cmet.2012.05.010
   Donia MS, 2015, SCIENCE, V349, DOI 10.1126/science.1254766
   Dowling RJO, 2016, CELL METAB, V23, P567, DOI 10.1016/j.cmet.2016.03.006
   Escos A, 2016, FRONT CELL DEV BIOL, V4, DOI 10.3389/fcell.2016.00031
   Garcia-Gonzalez AP, 2017, CELL, V169, P431, DOI 10.1016/j.cell.2017.03.046
   Grosdidier A, 2011, NUCLEIC ACIDS RES, V39, pW270, DOI 10.1093/nar/gkr366
   Haiser HJ, 2013, SCIENCE, V341, P295, DOI 10.1126/science.1235872
   Hawley SA, 2014, BIOCHEM J, V459, P275, DOI 10.1042/BJ20131344
   Heathcote HR, 2016, BIOCHEM J, V473, P4681, DOI 10.1042/BCJ20160211
   Horman S, 2006, J BIOL CHEM, V281, P5335, DOI 10.1074/jbc.M506850200
   Inoki K, 2002, NAT CELL BIOL, V4, P648, DOI 10.1038/ncb839
   Khamzina L, 2005, ENDOCRINOLOGY, V146, P1473, DOI 10.1210/en.2004-0921
   Kim B, 2015, J BIOL CHEM, V290, P19146, DOI 10.1074/jbc.M115.636852
   Koh A, 2018, CELL, V175, P947, DOI 10.1016/j.cell.2018.09.055
   Leosdottir M, 2010, AM HEART J, V159, P414, DOI 10.1016/j.ahj.2009.12.028
   Lin XB, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0039764
   Linares JF, 2015, CELL REP, V12, P1339, DOI 10.1016/j.celrep.2015.07.045
   Liu HY, 2009, AM J PHYSIOL-ENDOC M, V297, pE898, DOI 10.1152/ajpendo.00374.2009
   Marshall SM, 2017, DIABETOLOGIA, V60, P1561, DOI 10.1007/s00125-017-4343-y
   Moran N, 2011, NAT BIOTECHNOL, V29, P301, DOI 10.1038/nbt0411-301
   Musi N, 2002, DIABETES, V51, P2074, DOI 10.2337/diabetes.51.7.2074
   Ning JY, 2011, ENDOCRINOLOGY, V152, P3143, DOI 10.1210/en.2011-0155
   Owen MR, 2000, BIOCHEM J, V348, P607, DOI 10.1042/0264-6021:3480607
   Ozes O.B.L., 2008, US patent, Patent No. [WO2005040758A2, 2005040758A2]
   Panebianco C, 2018, CANCER CHEMOTH PHARM, V81, P773, DOI 10.1007/s00280-018-3549-0
   Pryor R, 2019, CELL, V178, P1299, DOI 10.1016/j.cell.2019.08.003
   Risson V, 2009, J CELL BIOL, V187, P859, DOI 10.1083/jcb.200903131
   Saitta KS, 2014, XENOBIOTICA, V44, P28, DOI 10.3109/00498254.2013.811314
   Sajan MP, 2015, J LIPID RES, V56, P70, DOI 10.1194/jlr.M052977
   Sarbassov DD, 2005, SCIENCE, V307, P1098, DOI 10.1126/science.1106148
   Scott TA, 2017, CELL, V169, P442, DOI 10.1016/j.cell.2017.03.040
   Shaw RJ, 2005, SCIENCE, V310, P1642, DOI 10.1126/science.1120781
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Spanogiannopoulos P, 2016, NAT REV MICROBIOL, V14, P273, DOI 10.1038/nrmicro.2016.17
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Suzuki T, 2013, MOL CELL, V50, P407, DOI 10.1016/j.molcel.2013.03.022
   SVARTZ N, 1988, AM J GASTROENTEROL, V83, P497
   Tomas-Loba A, 2019, NATURE, V568, P557, DOI 10.1038/s41586-019-1112-8
   Uchimura Y, 2018, IMMUNITY, V49, P545, DOI 10.1016/j.immuni.2018.08.004
   Valentine RJ, 2014, ARCH BIOCHEM BIOPHYS, V562, P62, DOI 10.1016/j.abb.2014.08.013
   van Vliet MJ, 2009, CLIN INFECT DIS, V49, P262, DOI 10.1086/599346
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Xie XD, 2011, P NATL ACAD SCI USA, V108, P6474, DOI 10.1073/pnas.1016132108
   Yang G, 2015, CELL REP, V12, P937, DOI 10.1016/j.celrep.2015.07.016
   Yin N, 2016, ONCOGENE, V35, P1039, DOI 10.1038/onc.2015.158
   Zhang DH, 2010, J CLIN INVEST, V120, P2805, DOI 10.1172/JCI43008
   Zhang EM, 2019, CELL METAB, V29, P64, DOI 10.1016/j.cmet.2018.09.008
   Zhang WS, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0037103
   Zhang XQ, 2015, SCI REP-UK, V5, DOI 10.1038/srep10737
   Zhou GC, 2001, J CLIN INVEST, V108, P1167, DOI 10.1172/JCI200113505
   Zimmermann M, 2019, NATURE, V570, P462, DOI 10.1038/s41586-019-1291-3
NR 60
TC 52
Z9 54
U1 1
U2 20
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
SN 1550-4131
EI 1932-7420
J9 CELL METAB
JI Cell Metab.
PD OCT 6
PY 2020
VL 32
IS 4
BP 643
EP +
DI 10.1016/j.cmet.2020.07.012
PG 15
WC Cell Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Endocrinology & Metabolism
GA OH1IK
UT WOS:000582325100015
PM 32783890
OA hybrid, Green Published
DA 2023-06-08
ER

PT J
AU Al Kattar, S
   Jurjus, R
   Pinon, A
   Leger, DY
   Jurjus, A
   Boukarim, C
   Diab-Assaf, M
   Liagre, B
AF Al Kattar, Sahar
   Jurjus, Rosalyn
   Pinon, Aline
   Leger, David Yannick
   Jurjus, Abdo
   Boukarim, Chawki
   Diab-Assaf, Mona
   Liagre, Bertrand
TI Metformin and Probiotics in the Crosstalk between Colitis-Associated
   Colorectal Cancer and Diabetes in Mice
SO CANCERS
LA English
DT Article
DE colorectal cancer; microbiota; inflammation; diabetes; oxidative stress;
   probiotics
ID INFLAMMATORY-BOWEL-DISEASE; NF-KAPPA-B; GUT MICROBIOTA; COLON-CANCER;
   TNF-ALPHA; MODEL; MELLITUS; SUPPLEMENTATION; INHIBITION; MECHANISMS
AB The co-occurrence of colorectal cancer (CRC) and diabetes mellitus along with inflammation and dismicrobism has been frequently reported. Several studies shed light on the antioncogenic potential of metformin on colorectal carcinogenesis. This study aimed to demonstrate that metformin in association with probiotics acts in a synergic effect in breaking the crosstalk, thus inhibiting CRC progression, improving diabetes, and reducing inflammation. Ninety-six male Balb/c mice, 6-8 weeks old, were divided into 16 control and experimental groups to assess the effect of the different treatments and combinations at the clinical, histological, and molecular levels. Metformin and probiotics showed beneficial outcomes on CRC and diabetes, alone and most importantly in combination. Their effects were exerted by inhibiting the inflammatory process whereby a downregulation of IL-6 and TNF-alpha as well as oxidative stress were depicted. The characterization of the effects of probiotics and metformin on CRC and diabetes sheds light on the role of inflammation and microbiota in this crosstalk. Deciphering the downstream signaling pathways elicited by these compounds will help in developing new effective targeted treatment modalities.
C1 [Al Kattar, Sahar; Pinon, Aline; Leger, David Yannick; Liagre, Bertrand] Univ Limoges, Fac Pharm, Lab PEIRENE EA 7500, 2 Rue Docteur Raymond Marcland, F-87025 Limoges, France.
   [Al Kattar, Sahar; Diab-Assaf, Mona] Lebanese Univ, Doctoral Sch Sci & Technol, Hadath 99000, Lebanon.
   [Al Kattar, Sahar; Jurjus, Rosalyn; Jurjus, Abdo] Amer Univ Beirut, Dept Anat Cell Biol & Physiol, Beirut 11072020, Lebanon.
   [Boukarim, Chawki] Lebanese Univ, Fac Sci 3, Dept Chem, Mt Michel Ras Maska 826, El Koura, Lebanon.
C3 Universite de Limoges; American University of Beirut
RP Liagre, B (通讯作者)，Univ Limoges, Fac Pharm, Lab PEIRENE EA 7500, 2 Rue Docteur Raymond Marcland, F-87025 Limoges, France.; Jurjus, A (通讯作者)，Amer Univ Beirut, Dept Anat Cell Biol & Physiol, Beirut 11072020, Lebanon.
EM sahar_kattar@hotmail.com; rj58@aub.edu.lb; aline.pinon@unilim.fr;
   david.leger@unilim.fr; aj00@aub.edu.lb; cboukarim@ul.edu.lb;
   mdiabassaf@ul.edu.lb; bertrand.liagre@unilim.fr
RI Liagre, Bertrand/G-2979-2013
OI Pinon, Aline/0000-0002-3123-7495; Liagre, Bertrand/0000-0003-4148-2598
FU Ministere de l'Enseignement Superieur, de la Recherche et de
   l'Innovation through the European Fund of Regional Development FEDER
   2014-2020; Conseil Regional Nouvelle Aquitaine; Ligue contre le Cancer;
   American University of Beirut, Seed grant
FX The expenses of this work were defrayed in part by the Ministere de
   l'Enseignement Superieur, de la Recherche et de l'Innovation through the
   European Fund of Regional Development FEDER 2014-2020, by the Conseil
   Regional Nouvelle Aquitaine, and by the Ligue contre le Cancer; and by
   the American University of Beirut, Seed grant.
CR Akbari V, 2016, NUTR REV, V74, P774, DOI 10.1093/nutrit/nuw039
   Barriere G, 2013, ANTI-CANCER AGENT ME, V13, P333, DOI 10.2174/1871520611313020018
   Blandino G, 2016, DIABETES METAB, V42, P303, DOI 10.1016/j.diabet.2016.04.004
   Boman BM, 2004, AM J PATHOL, V165, P1489, DOI 10.1016/S0002-9440(10)63407-4
   Chassaing Benoit, 2014, Curr Protoc Immunol, V104, DOI 10.1002/0471142735.im1525s104
   Chaudhury A, 2017, FRONT ENDOCRINOL, V8, DOI 10.3389/fendo.2017.00006
   Chen GY, 2018, CLIN COLON RECT SURG, V31, P192, DOI 10.1055/s-0037-1602239
   Cho NH, 2018, DIABETES RES CLIN PR, V138, P271, DOI 10.1016/j.diabres.2018.02.023
   De Almeida CV, 2019, WORLD J GASTROENTERO, V25, P151, DOI 10.3748/wjg.v25.i2.151
   Deeds MC, 2011, LAB ANIM-UK, V45, P131, DOI 10.1258/la.2010.010090
   dos Reis SA, 2017, NUTR RES, V37, P1, DOI 10.1016/j.nutres.2016.11.009
   Drago L, 2019, MICROORGANISMS, V7, DOI 10.3390/microorganisms7030066
   Eichele DD, 2017, WORLD J GASTROENTERO, V23, P6016, DOI 10.3748/wjg.v23.i33.6016
   Gao CX, 2017, AM J PATHOL, V187, P2323, DOI 10.1016/j.ajpath.2017.06.011
   Gayathri D, 2016, EC NUTR, V5, P1191, DOI DOI 10.1016/j.mhp.2017.01.003
   Geagea Alice Gerges, 2019, Oncotarget, V10, P1284, DOI 10.18632/oncotarget.26641
   Ghazavi A, 2009, Pak J Biol Sci, V12, P690, DOI 10.3923/pjbs.2009.690.695
   Gianchecchi E, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20020283
   Giovannucci E, 2010, DIABETES CARE, V33, P1674, DOI 10.2337/dc10-0666
   Gonzalez N, 2017, ONCOTARGET, V8, P18456, DOI 10.18632/oncotarget.14472
   Higurashi T, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00622
   Hussein IAH, 2008, WORLD J GASTROENTERO, V14, P4028, DOI 10.3748/wjg.14.4028
   Ito M, 1999, BIOL PHARM BULL, V22, P988
   Jemal A, 2011, CA-CANCER J CLIN, V61, P134, DOI [10.3322/caac.20107, 10.3322/caac.20115]
   Jeon HJ, 2018, NUTR RES PRACT, V12, P13, DOI 10.4162/nrp.2018.12.2.101
   Jurjus A, 2006, CAN J PHYSIOL PHARM, V84, P1191, DOI 10.1139/Y06-069
   Jurjus A, 2016, BBA CLIN, V5, P16, DOI 10.1016/j.bbacli.2015.11.002
   Khan MT, 2014, CELL METAB, V20, P753, DOI 10.1016/j.cmet.2014.07.006
   Kim SW, 2010, INFLAMM BOWEL DIS, V16, P1514, DOI 10.1002/ibd.21262
   Kosumi Keisuke, 2018, J Lab Precis Med, V3, DOI 10.21037/jlpm.2018.09.05
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Lega IC, 2020, ENDOCR REV, V41, P33, DOI 10.1210/endrev/bnz014
   Liu CX, 2016, CYTOKINE, V86, P100, DOI 10.1016/j.cyto.2016.06.028
   Liu LQ, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19020506
   Luo CX, 2017, MEDIAT INFLAMM, V2017, DOI 10.1155/2017/5126048
   Madempudi RS, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0225168
   Mendes MCS, 2018, WORLD J GASTROENTERO, V24, P1995, DOI 10.3748/wjg.v24.i18.1995
   Miraghajani M, 2017, SAO PAULO MED J, V135, P169, DOI 10.1590/1516-3180.2016.0311271216
   Myant KB, 2013, CELL STEM CELL, V12, P761, DOI 10.1016/j.stem.2013.04.006
   Pandey A, 2017, BIOMED PHARMACOTHER, V94, P1121, DOI 10.1016/j.biopha.2017.08.020
   Parang B, 2016, METHODS MOL BIOL, V1422, P297, DOI 10.1007/978-1-4939-3603-8_26
   Pascale A, 2019, CURR OPIN PHARMACOL, V49, P1, DOI 10.1016/j.coph.2019.03.011
   Peng M, 2017, CANCER TREAT REV, V54, P24, DOI 10.1016/j.ctrv.2017.01.005
   Ray AL, 2018, INT J CANCER, V142, P1702, DOI 10.1002/ijc.31191
   Ryan PM, 2020, CAN J DIABETES, V44, P146, DOI 10.1016/j.jcjd.2019.05.008
   Sakata N, 2012, EXP DIABETES RES, DOI 10.1155/2012/256707
   Saus E, 2019, MOL ASPECTS MED, V69, P93, DOI 10.1016/j.mam.2019.05.001
   Shirakami Yohei, 2018, Oncotarget, V9, P33972, DOI 10.18632/oncotarget.26119
   Soufli Imene, 2016, World J Gastrointest Pharmacol Ther, V7, P353, DOI 10.4292/wjgpt.v7.i3.353
   Stone EL, 2010, METHOD ENZYMOL, V479, P155, DOI 10.1016/S0076-6879(10)79009-1
   Tfaily MA, 2019, ANN GLOB HEALTH, V85, DOI 10.5334/aogh.2437
   Toscano M, 2017, DIGEST LIVER DIS, V49, P1177, DOI 10.1016/j.dld.2017.07.011
   Tunctan B, 1998, PHARMACOL RES, V38, P405, DOI 10.1006/phrs.1998.0381
   Ursell LK, 2014, GASTROENTEROLOGY, V146, P1470, DOI 10.1053/j.gastro.2014.03.001
   Wang X, 2017, J PEDIATR ENDOCR MET, V30, P611, DOI 10.1515/jpem-2016-0230
   Wang Y, 2014, MUCOSAL IMMUNOL, V7, P1106, DOI 10.1038/mi.2013.126
   Wang YW, 2017, DRUG DES DEV THER, V11, P2421, DOI 10.2147/DDDT.S141675
   Wellen KE, 2005, J CLIN INVEST, V115, P1111, DOI 10.1172/JCI200525102
   Wen L, 2017, J NUTR, V147, p1468S, DOI 10.3945/jn.116.240754
   Wu CC, 2019, AM J CANCER RES, V9, P872
   Wu YL, 2014, INT J MED SCI, V11, P1185, DOI 10.7150/ijms.10001
   Yu LCH, 2018, J BIOMED SCI, V25, DOI 10.1186/s12929-018-0483-8
   Zhang XQ, 2015, SCI REP-UK, V5, DOI 10.1038/srep10737
   Zhao R, 2013, PLOS COMPUT BIOL, V9, DOI 10.1371/journal.pcbi.1003082
   Zitvogel L, 2018, SCIENCE, V359, P1366, DOI 10.1126/science.aar6918
NR 65
TC 10
Z9 10
U1 1
U2 18
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6694
J9 CANCERS
JI Cancers
PD JUL
PY 2020
VL 12
IS 7
AR 1857
DI 10.3390/cancers12071857
PG 31
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA MX2PD
UT WOS:000557567200001
PM 32664279
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Reimer, RA
   Grover, GJ
   Koetzner, L
   Gahler, RJ
   Lyon, MR
   Wood, S
AF Reimer, Raylene A.
   Grover, Gary J.
   Koetzner, Lee
   Gahler, Roland J.
   Lyon, Michael R.
   Wood, Simon
TI Combining sitagliptin/metformin with a functional fiber delays diabetes
   progression in Zucker rats
SO JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
DE PolyGlycopleX; DPP4 inhibitor; obesity; diabetes medication; glycemia
ID DIPEPTIDYL PEPTIDASE-4 INHIBITOR; GLUCAGON-LIKE PEPTIDE-1; GLYCEMIC
   CONTROL; GUT MICROBIOTA; PREBIOTIC FIBER; SATIETY HORMONE; BODY-WEIGHT;
   METFORMIN; EFFICACY; OBESITY
AB Our primary objective was to determine whether administering the viscous and fermentable polysaccharide PolyGlycopleX (PGX) with metformin (MET) or sitagliptin/metformin (S/MET) reduces hyperglycemia in Zucker diabetic fatty (ZDF) rats more so than monotherapy of each. Glucose tolerance, adiposity, satiety hormones and mechanisms related to dipeptidyl peptidase 4 activity, gut microbiota and, hepatic and pancreatic histology were examined. Male ZDF rats (9-10 weeks of age) were randomized to: i) cellulose/vehicle (control, C); ii) PGX (5% wt/wt)/vehicle (PGX); iii) cellulose/metformin (200 mg/kg) (MET); iv) cellulose/ S/MET (10 mg/kg + 200 mg/kg) (S/MET); v) PGX (5%) CMET (200 mg/kg) (PGX + MET); vi) cellulose/sitagliptin/MET (5%) + (10 mg/kg + 200 mg/kg) (PGX + S/MET) for 6 weeks. PGX + MET and PGX + S/MET reduced glycemia compared with C and singular treatments (P=0.001). Weekly fasted and fed blood glucose levels were lower in PGX + MET and PGXCS/MET compared with all other groups at weeks 4, 5, and 6 (P=0.001). HbA1c was lower in PGX + S/MET than C, MET, S/MET, and PGX at week 6 (P=0.001). Fat mass was lower and GLP1 was higher in PGX + S/MET compared with all other groups (P=0.001). beta-cell mass was highest and islet degeneration lowest in PGX + S/MET. Hepatic lipidosis was significantly lower in PGX + S/MET compared with PGX or S/MET alone. When combined with PGX, both MET and S/MET markedly reduce glycemia; however, PGX + S/MET appears advantageous over PGX + MET in terms of increased b-cell mass and reduced adiposity. Both combination treatments attenuated diabetes in the obese Zucker rat.
C1 [Reimer, Raylene A.] Univ Calgary, Fac Kinesiol, Calgary, AB T2N 1N4, Canada.
   [Reimer, Raylene A.] Univ Calgary, Fac Med, Dept Biochem & Mol Biol, Calgary, AB T2N 1N4, Canada.
   [Grover, Gary J.; Koetzner, Lee] Dept Pharmacol, Prod Safety Labs, Dayton, NJ USA.
   [Grover, Gary J.] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Physiol & Biophys, Piscataway, NJ 08854 USA.
   [Gahler, Roland J.; Wood, Simon] Factors Grp Nutr Companies Inc R&D, Burnaby, BC, Canada.
   [Lyon, Michael R.] Canadian Ctr Funct Med, Coquitlam, BC, Canada.
   [Lyon, Michael R.; Wood, Simon] Univ British Columbia, Food Nutr & Hlth Program, Vancouver, BC V5Z 1M9, Canada.
C3 University of Calgary; University of Calgary; Rutgers State University
   New Brunswick; Rutgers State University Medical Center; University of
   British Columbia
RP Reimer, RA (通讯作者)，Univ Calgary, Fac Kinesiol, 2500 Univ Dr NW, Calgary, AB T2N 1N4, Canada.
EM reimer@ucalgary.ca
OI Koetzner, Lee/0000-0002-1208-6046; Reimer, Raylene/0000-0001-5088-7947
FU InovoBiologic, Inc., Calgary, Canada
FX This project was funded by InovoBiologic, Inc., Calgary, Canada.
CR Ahren B, 2007, DIABETES CARE, V30, P1344, DOI 10.2337/dc07-0233
   Amer Diabet Associat, 2008, DIABETES CARE, V31, pS61, DOI 10.2337/dc08-S061
   ANDERSON JW, 1994, J NUTR, V124, P78, DOI 10.1093/jn/124.1.78
   Aschner P, 2006, DIABETES CARE, V29, P2632, DOI 10.2337/dc06-0703
   Babio N, 2010, NUTR HOSP, V25, P327, DOI 10.3305/nh.2010.25.3.4459
   Bomhof MR, 2013, OBESITY IN PRESS, DOI [10.1002/oby.20632, DOI 10.1002/0BY.20632)]
   Cani PD, 2009, GUT, V58, P1091, DOI 10.1136/gut.2008.165886
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Cani PD, 2012, GUT MICROBES, V3, P279, DOI 10.4161/gmic.19625
   Charbonnel B, 2006, DIABETES CARE, V29, P2638, DOI 10.2337/dc06-0706
   Chen B, 2011, EXP BIOL MED, V236, P309, DOI 10.1258/ebm.2010.010161
   Chutkan R, 2012, J AM ACAD NURSE PRAC, V24, P476, DOI 10.1111/j.1745-7599.2012.00758.x
   Daousi C, 2006, POSTGRAD MED J, V82, P280, DOI 10.1136/pmj.2005.039032
   Eller LK, 2010, J NUTR, V140, P1234, DOI 10.3945/jn.109.119008
   Farag YMK, 2011, NEPHROL DIAL TRANSPL, V26, P28, DOI 10.1093/ndt/gfq576
   Fass AD, 2013, ADV THER, V30, P337, DOI 10.1007/s12325-013-0023-6
   Franco M, 2013, BMJ-BRIT MED J, V346, DOI 10.1136/bmj.f1515
   Grover GJ, 2011, LIFE SCI, V88, P392, DOI 10.1016/j.lfs.2010.11.014
   Grover GJ, 2011, FRONT PHARMACOL, V2, DOI 10.3389/fphar.2011.00047
   Gutierrez DA, 2009, CURR DIABETES REP, V9, P26, DOI 10.1007/s11892-009-0006-9
   Halban PA, 2010, J CLIN ENDOCR METAB, V95, P1034, DOI 10.1210/jc.2009-1819
   Inzucchi SE, 2002, JAMA-J AM MED ASSOC, V287, P360, DOI 10.1001/jama.287.3.360
   Irvine C, 2009, AUST J PHYSIOTHER, V55, P237, DOI 10.1016/S0004-9514(09)70003-0
   Kaji K, 2013, J GASTROENT IN PRESS
   Kirno Y, 2009, BIOL PHARM BULL, V32, P463, DOI 10.1248/bpb.32.463
   Lappi J, 2013, CRIT REV FOOD SCI, V53, P631, DOI 10.1080/10408398.2010.550388
   Ley RE, 2006, NATURE, V444, P1022, DOI 10.1038/4441022a
   Maiztegui B, 2011, CLIN SCI, V120, P73, DOI 10.1042/CS20100372
   Minekus M, 1999, APPL MICROBIOL BIOT, V53, P108, DOI 10.1007/s002530051622
   Mulherin AJ, 2011, ENDOCRINOLOGY, V152, P4610, DOI 10.1210/en.2011-1485
   Nath DS, 2005, CLIN TRANSPLANT, V19, P792, DOI 10.1111/j.1399-0012.2005.00423.x
   National Heart Lung and Blood Institute National Institute of Diabetes and Digestive and Kidney Diseases, 1998, NIH PUBLICATION, V98-4083, DOI DOI 10.1002/J.1550-8528.1998.TB00690.X
   Nauck MA, 2007, DIABETES OBES METAB, V9, P194, DOI 10.1111/j.1463-1326.2006.00704.x
   Papanas N, 2009, EXPERT OPIN PHARMACO, V10, P2395, DOI 10.1517/14656560903176453
   Parnell JA, 2012, BRIT J NUTR, V107, P601, DOI 10.1017/S0007114511003163
   Parnell JA, 2012, LIVER INT, V32, P701, DOI 10.1111/j.1478-3231.2011.02730.x
   Parnell JA, 2009, AM J CLIN NUTR, V89, P1751, DOI 10.3945/ajcn.2009.27465
   Peterson R.G., 1990, ILAR NEWS, V32, P16, DOI DOI 10.1093/ILAR.32.3.16
   Pyra KA, 2012, J NUTR, V142, P213, DOI 10.3945/jn.111.147132
   Reimer RA, 2013, OBESITY, V21, pE379, DOI 10.1002/oby.20435
   Reimer RA, 2012, J NUTR, V142, P1812, DOI 10.3945/jn.112.163204
   Reimer RA, 2012, J PROTEOME RES, V11, P4065, DOI 10.1021/pr300487s
   Sangle GV, 2012, ENDOCRINOLOGY, V153, P564, DOI 10.1210/en.2011-1732
   Scheen AJ, 2013, DIABETES METAB, V39, P179, DOI 10.1016/j.diabet.2013.02.006
   SHAMOON H, 1993, NEW ENGL J MED, V329, P977, DOI 10.1056/nejm199309303291401
   Shaw JE, 2010, DIABETES RES CLIN PR, V87, P4, DOI 10.1016/j.diabres.2009.10.007
   Solis-Herrera C, 2013, DIABETES CARE, V36, P2756, DOI 10.2337/dc12-2072
   St Onge Erin L, 2012, P T, V37, P699
   Stein SA, 2013, EXPERT OPIN DRUG SAF, V12, P153, DOI 10.1517/14740338.2013.752813
   Turner RC, 1998, LANCET, V352, P837, DOI 10.1016/s0140-6736(98)07019-6
   Vuksan V, 2009, CURR DIABETES REP, V9, P405, DOI 10.1007/s11892-009-0062-1
   Weickert MO, 2008, J NUTR, V138, P439, DOI 10.1093/jn/138.3.439
   Weir GC, 2013, ANN NY ACAD SCI, V1281, P92, DOI 10.1111/nyas.12031
   Wichmann A, 2013, CELL HOST MICROBE, V14, P582, DOI 10.1016/j.chom.2013.09.012
   Zhang HS, 2009, P NATL ACAD SCI USA, V106, P2365, DOI 10.1073/pnas.0812600106
NR 55
TC 22
Z9 22
U1 1
U2 17
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA STARLING HOUSE, 1600 BRISTOL PARKWAY N, BRISTOL, ENGLAND
SN 0022-0795
EI 1479-6805
J9 J ENDOCRINOL
JI J. Endocrinol.
PD MAR
PY 2014
VL 220
IS 3
BP 361
EP 373
DI 10.1530/JOE-13-0484
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AC7FN
UT WOS:000332693200017
PM 24389593
OA Bronze
DA 2023-06-08
ER

PT J
AU Ejtahed, HS
   Tito, RY
   Siadat, SD
   Hasani-Ranjbar, S
   Hoseini-Tavassol, Z
   Rymenans, L
   Verbeke, K
   Soroush, AR
   Raes, J
   Larijani, B
AF Ejtahed, Hanieh-Sadat
   Tito, Raul Y.
   Siadat, Seyed-Davar
   Hasani-Ranjbar, Shirin
   Hoseini-Tavassol, Zahra
   Rymenans, Leen
   Verbeke, Kristin
   Soroush, Ahmad-Reza
   Raes, Jeroen
   Larijani, Bagher
TI Metformin induces weight loss associated with gut microbiota alteration
   in non-diabetic obese women: a randomized double-blind clinical trial
SO EUROPEAN JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
ID RELATIVE VALIDITY; E. COLI; INDIVIDUALS
AB Objective: The increasing prevalence of obesity over the past few decades constitutes a global health challenge. Pharmacological therapy is recommended to accompany life-style modification for obesity management. Here, we perform a clinical trial to investigate the effects of metformin on anthropometric indices and gut microbiota composition in non-diabetic, treatment-naive obese women with a low-calorie diet (LCD).
   Design: Randomized double-blind parallel-group clinical trail
   Methods: Forty-six obese women were randomly assigned to the metformin (500 mg/tab) or placebo groups using computer-generated random numbers. Subjects in both groups took two tablets per day for 2 months. Anthropometric measurements and collection of blood and fecal samples were done at the baseline and at the end of the trial. Gut microbiota composition was assessed using 16S rRNA amplicon sequencing.
   Results: Twenty-four and twenty-two subjects were included in the metformin + LCD and placebo + LCD groups, respectively; at the end of trial, 20 and 16 subjects were analyzed. The metformin + LCD and placebo + LCD caused a 4.5 and 2.6% decrease in BMI from the baseline values, respectively (P < 0.01). Insulin concentration decreased in the metformin + LCD group (P = 0.046). The overall fecal microbiota composition and diversity were unaffected in the metformin + LCD group. However, a significant specific increase in Escherichia/Shigello abundance was observed after metformin + LCD intervention (P = 0.026). Fecal acetate concentration, but not producers, was significantly higher in the placebo + LCD group, adjusted for baseline values and BMI (P = 0.002).
   Conclusions: Despite the weight reduction after metformin intake, the overall fecal microbiota composition remained largely unchanged in obese women, with exception of changes in specific proteobacterial groups.
C1 [Ejtahed, Hanieh-Sadat; Hasani-Ranjbar, Shirin; Soroush, Ahmad-Reza] Univ Tehran Med Sci, Obes & Eating Habits Res Ctr, Endocrinol & Metab Clin Sci Inst, Tehran, Iran.
   [Tito, Raul Y.; Rymenans, Leen; Raes, Jeroen] Katholieke Univ Leuven, Dept Microbiol & Immunol, Rega Inst, Leuven, Belgium.
   [Siadat, Seyed-Davar; Hoseini-Tavassol, Zahra] Pasteur Inst Iran, Microbiol Res Ctr, Dept Mycobacteriol & Pulm Res, Tehran, Iran.
   [Verbeke, Kristin] Katholieke Univ Leuven, Translat Res Gastrointestinal Disorders, Leuven, Belgium.
   [Larijani, Bagher] Univ Tehran Med Sci, Endocrinol & Metab Res Ctr, Endocrinol & Metab Clin Sci Inst, Tehran, Iran.
C3 Tehran University of Medical Sciences; KU Leuven; Le Reseau
   International des Instituts Pasteur (RIIP); Pasteur Institute of Iran;
   KU Leuven; Tehran University of Medical Sciences
RP Soroush, AR (通讯作者)，Univ Tehran Med Sci, Obes & Eating Habits Res Ctr, Endocrinol & Metab Clin Sci Inst, Tehran, Iran.; Raes, J (通讯作者)，Katholieke Univ Leuven, Dept Microbiol & Immunol, Rega Inst, Leuven, Belgium.
EM soroush.journal@gmail.com; jeroen.raes@med.kuleuven.be
RI Tito, Raul/CAG-3546-2022; ejtahed, hanieh/AAH-4921-2021; larijani,
   Bagher/ABE-3315-2020; Hoseini Tavassol, Zahra/HJP-2607-2023; Siadat,
   Seyed Davar/A-2204-2012; raes, jeroen/D-7835-2018
OI larijani, Bagher/0000-0001-5386-7597; Siadat, Seyed
   Davar/0000-0002-6892-5603; raes, jeroen/0000-0002-1337-041X; Verbeke,
   Kristin/0000-0002-5352-7565; Tito Tadeo, Raul
   Yhossef/0000-0001-9660-7621; Hoseini Tavassol, Zahra/0000-0002-2432-2114
FU National Institute for Medical Research Development (NIMAD) [942022]
FX This work was supported by the National Institute for Medical Research
   Development (NIMAD) (grant number: 942022).
CR Andolfi C, 2018, J LAPAROENDOSC ADV S, V28, P919, DOI 10.1089/lap.2018.0380
   Beaumont M, 2016, GENOME BIOL, V17, DOI 10.1186/s13059-016-1052-7
   BENJAMINI Y, 1995, J R STAT SOC B, V57, P289, DOI 10.1111/j.2517-6161.1995.tb02031.x
   Bolnick DI, 2014, NAT COMMUN, V5, DOI 10.1038/ncomms5500
   Breton J, 2016, CELL METAB, V23, P324, DOI 10.1016/j.cmet.2015.10.017
   Callahan BJ, 2016, NAT METHODS, V13, P581, DOI [10.1038/NMETH.3869, 10.1038/nmeth.3869]
   Dao MC, 2016, GUT, V65, P426, DOI 10.1136/gutjnl-2014-308778
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Dominianni C, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0124599
   Ejtahed HS, 2016, HORM METAB RES, V48, P349, DOI 10.1055/s-0042-107792
   Ejtahed HS, 2017, ALTERN THER HEALTH M, V23, P8
   Ejtahed HS, 2018, MICROB PATHOGENESIS, V116, P13, DOI 10.1016/j.micpath.2017.12.074
   Esfahani FH, 2010, J EPIDEMIOL, V20, P150, DOI 10.2188/jea.JE20090083
   Falony G, 2016, SCIENCE, V352, P560, DOI 10.1126/science.aad3503
   Finkelstein EA, 2012, AM J PREV MED, V42, P563, DOI 10.1016/j.amepre.2011.10.026
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Graff SK, 2016, INT J CLIN PRACT, V70, P450, DOI 10.1111/ijcp.12787
   Haro C, 2017, MOL NUTR FOOD RES, V61, DOI 10.1002/mnfr.201700300
   Hensley RD, 2018, NURSE PRACT, V43, P41, DOI 10.1097/01.NPR.0000534941.27466.0b
   Hildebrand F, 2014, MICROBIOME, V2, DOI 10.1186/2049-2618-2-30
   Hjorth MF, 2019, INT J OBESITY, V43, P149, DOI 10.1038/s41366-018-0093-2
   Hoffmann Irene S, 2003, Am J Ther, V10, P447, DOI 10.1097/00045391-200311000-00012
   Holmes I, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0030126
   Jafari-Adli S, 2014, J DIABETES METAB DIS, V13, DOI 10.1186/s40200-014-0121-2
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Ma W, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.01336
   Malin SK, 2014, CURR OPIN ENDOCRINOL, V21, P323, DOI 10.1097/MED.0000000000000095
   Malin SK, 2013, OBESITY, V21, P93, DOI 10.1002/oby.20235
   Maniar K, 2017, MED HYPOTHESES, V104, P117, DOI 10.1016/j.mehy.2017.06.001
   Mardinoglu A, 2016, CELL METAB, V23, P10, DOI 10.1016/j.cmet.2015.12.012
   Million M, 2013, INT J OBESITY, V37, P1460, DOI 10.1038/ijo.2013.20
   Mirmiran P, 2010, PUBLIC HEALTH NUTR, V13, P654, DOI 10.1017/S1368980009991698
   Montandon SA, 2017, GENES-BASEL, V8, DOI 10.3390/genes8100250
   Peters BA, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-28126-1
   Piche ME, 2018, PROG CARDIOVASC DIS, V61, P103, DOI 10.1016/j.pcad.2018.06.004
   Roager HM, 2014, APPL ENVIRON MICROB, V80, P1142, DOI 10.1128/AEM.03549-13
   Rodriguez J, 2018, CURR OPIN CLIN NUTR, V21, P294, DOI 10.1097/MCO.0000000000000468
   Rosario D, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.00775
   Rothschild D, 2018, NATURE, V555, P210, DOI 10.1038/nature25973
   Schutt M, 2015, EXP CLIN ENDOCR DIAB, V123, P622, DOI 10.1055/s-0035-1559608
   Seifarth C, 2013, EXP CLIN ENDOCR DIAB, V121, P27, DOI 10.1055/s-0032-1327734
   Tamanai-Shacoori Z, 2017, FUTURE MICROBIOL, V12, P157, DOI 10.2217/fmb-2016-0130
   Tito RY, 2017, ARTHRITIS RHEUMATOL, V69, P114, DOI 10.1002/art.39802
   Tong XL, 2018, MBIO, V9, DOI 10.1128/mBio.02392-17
   Tseng CH, 2019, J FORMOS MED ASSOC, V118, pS3, DOI 10.1016/j.jfma.2018.07.009
   Wang Q, 2007, APPL ENVIRON MICROB, V73, P5261, DOI 10.1128/AEM.00062-07
   Winter SE, 2013, SCIENCE, V339, P708, DOI 10.1126/science.1232467
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Yatsunenko T, 2012, NATURE, V486, P222, DOI 10.1038/nature11053
   Zhang XQ, 2015, SCI REP-UK, V5, DOI 10.1038/srep10737
   Zhernakova A, 2016, SCIENCE, V352, P565, DOI 10.1126/science.aad3369
NR 51
TC 32
Z9 32
U1 1
U2 22
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA STARLING HOUSE, 1600 BRISTOL PARKWAY N, BRISTOL, ENGLAND
SN 0804-4643
EI 1479-683X
J9 EUR J ENDOCRINOL
JI Eur. J. Endocrinol.
PD MAR
PY 2019
VL 180
IS 3
BP 165
EP 176
DI 10.1530/EJE-18-0826
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA HJ4NR
UT WOS:000457151200007
PM 30540558
OA Green Accepted, Bronze
DA 2023-06-08
ER

PT J
AU Balvers, M
   Deschasaux, M
   van den Born, BJ
   Zwinderman, K
   Nieuwdorp, M
   Levin, E
AF Balvers, Manon
   Deschasaux, Melanie
   van den Born, Bert-Jan
   Zwinderman, Koos
   Nieuwdorp, Max
   Levin, Evgeni
TI Analyzing Type 2 Diabetes Associations with the Gut Microbiome in
   Individuals from Two Ethnic Backgrounds Living in the Same Geographic
   Area
SO NUTRIENTS
LA English
DT Article
DE type 2 diabetes; ethnicity; gut microbiome; metformin; treatment-naive;
   HELIUS study
ID POPULATION; METFORMIN; PROPIONATE; METAGENOME; MAFFT
AB It is currently unknown whether associations between gut microbiota composition and type 2 diabetes (T2D) differ according to the ethnic background of individuals. Thus, we studied these associations in participants from two ethnicities characterized by a high T2D prevalence and living in the same geographical area, using the Healthy Life In Urban Settings (HELIUS) study. We included 111 and 128 T2D participants on metformin (Met-T2D), 78 and 49 treatment-naive T2D (TN-T2D) participants, as well as a 1:1 matched group of healthy controls from, respectively, African Surinamese and South-Asian Surinamese descent. Fecal microbiome profiles were obtained through 16S rRNA gene sequencing. Univariate and machine learning analyses were used to explore the associations between T2D and the composition and function of the gut microbiome in both ethnicities, comparing Met-T2D and TN-T2D participants to their respective healthy control. We found a lower alpha-diversity for South-Asian Surinamese TN-T2D participants but no significant associations between TN-T2D status and the abundance of bacterial taxa or functional pathways. In African Surinamese participants, we did not find any association between TN-T2D status and the gut microbiome. With respect to Met-T2D participants, we identified several bacterial taxa and functional pathways with a significantly altered abundance in both ethnicities. More alterations were observed in South-Asian Surinamese. Some altered taxa and pathways observed in both ethnicities were previously related to metformin use. This included a strong negative association between the abundance of Romboutsia and Met-T2D status. Other bacterial taxa were consistent with previous observations in T2D, including reduced butyrate producers such as Anaerostipes hadrus. Hence, our results highlighted both shared and unique gut microbial biomarkers of Met-T2D in individuals from different ethnicities but living in the same geographical area. Future research using higher-resolution shotgun sequencing is needed to clarify the role of ethnicity in the association between T2D and gut microbiota composition.
C1 [Balvers, Manon; van den Born, Bert-Jan; Nieuwdorp, Max; Levin, Evgeni] Amsterdam Univ Med Ctr, Dept Internal & Vasc Med, NL-1105 AZ Amsterdam, Netherlands.
   [Balvers, Manon; Levin, Evgeni] HorAIzon BV, NL-2625 GZ Delft, Netherlands.
   [Deschasaux, Melanie; Zwinderman, Koos] Amsterdam Univ Med Ctr, Dept Clin Epidemiol & Biostat, NL-1105 AZ Amsterdam, Netherlands.
   [van den Born, Bert-Jan] Amsterdam Univ Med Ctr, Dept Publ & Occupat Hlth, NL-1105 AZ Amsterdam, Netherlands.
RP Levin, E (通讯作者)，Amsterdam Univ Med Ctr, Dept Internal & Vasc Med, NL-1105 AZ Amsterdam, Netherlands.; Levin, E (通讯作者)，HorAIzon BV, NL-2625 GZ Delft, Netherlands.
EM m.balvers@amsterdamumc.nl; m.deschasaux@eren.smbh.univ-paris13.fr;
   b.j.vandenborn@amsterdamumc.nl; a.h.zwinderman@amsterdamumc.nl;
   m.nieuwdorp@amsterdamumc.nl; e.levin@amsterdamumc.nl
RI van den Born, Bert-Jan/E-4263-2017
OI van den Born, Bert-Jan H. (BJH)/0000-0003-0943-4393; Balvers,
   Manon/0000-0003-4094-5087; Deschasaux, Melanie/0000-0002-3359-420X
FU NNF CAMIT [2018]; ZONMW VICI [2020 [09150182010020]]; ZonMw for
   Technology Hotel grant [40-43500-98-5007]; HELIUS; Dutch Heart
   Foundation; Netherlands Organization for Health Research and Development
   (ZonMw); European Union [FP-7]; European Fund for the Integration of
   non-EU immigrants (EIF); Dutch Heart Foundation [2010T084]; ZonMw
   [200500003]; European Union (FP-7) [278901]; European Fund for the
   Integration of non-EU immigrants (EIF) [2013EIF013]
FX M.B. is appointed on a NNF CAMIT grant 2018 (to M.N.). M.N. is supported
   by a personal ZONMW VICI grant 2020 [09150182010020]. This research has
   been also supported by ZonMw for Technology Hotel grant
   [40-43500-98-5007]. The HELIUS study is conducted by the Amsterdam
   University Medical Centers, location AMC and the Public Health Service
   of Amsterdam. Both organizations provided core support for HELIUS. The
   HELIUS study is also funded by the Dutch Heart Foundation, the
   Netherlands Organization for Health Research and Development (ZonMw),
   the European Union (FP-7), and the European Fund for the Integration of
   non-EU immigrants (EIF). The study reported here was additionally
   supported by (an) additional grant(s) from the Dutch Heart Foundation
   [2010T084], ZonMw [200500003], European Union (FP-7) [278901], and
   European Fund for the Integration of non-EU immigrants (EIF)
   [2013EIF013] all assigned to K. Stronks.
CR Afolayan AO, 2020, HELIYON, V6, DOI 10.1016/j.heliyon.2020.e03971
   Allin KH, 2018, DIABETOLOGIA, V61, P810, DOI 10.1007/s00125-018-4550-1
   Alvarez-Silva C, 2021, GENOME MED, V13, DOI 10.1186/s13073-021-00856-4
   BENJAMINI Y, 1995, J R STAT SOC B, V57, P289, DOI 10.1111/j.2517-6161.1995.tb02031.x
   Beukers MH, 2015, EUR J CLIN NUTR, V69, P579, DOI 10.1038/ejcn.2014.180
   Bhute SS, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.00214
   Bryrup T, 2019, DIABETOLOGIA, V62, P1024, DOI 10.1007/s00125-019-4848-7
   Callahan BJ, 2016, NAT METHODS, V13, P581, DOI [10.1038/NMETH.3869, 10.1038/nmeth.3869]
   Das T, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-82538-0
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   DeFronzo RA, 2015, NAT REV DIS PRIMERS, V1, DOI 10.1038/nrdp.2015.19
   Dekker LH, 2011, BMC PUBLIC HEALTH, V11, DOI 10.1186/1471-2458-11-441
   Deschasaux M, 2018, NAT MED, V24, P1526, DOI 10.1038/s41591-018-0160-1
   Douglas GM, 2020, NAT BIOTECHNOL, V38, P685, DOI 10.1038/s41587-020-0548-6
   Doumatey AP, 2020, FRONT CELL INFECT MI, V10, DOI 10.3389/fcimb.2020.00063
   Edgar RC, 2010, BIOINFORMATICS, V26, P2460, DOI 10.1093/bioinformatics/btq461
   Elbere I, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0241338
   Elbere I, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0204317
   Falony G, 2016, SCIENCE, V352, P560, DOI 10.1126/science.aad3503
   Fisher A., 2018, ARXIV180101489
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Gaike AH, 2020, MSYSTEMS, V5, DOI 10.1128/mSystems.00578-19
   Gerard C, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00029
   Geurts P, 2006, MACH LEARN, V63, P3, DOI 10.1007/s10994-006-6226-1
   Ho DE, 2011, J STAT SOFTW, V42
   ID Federation, 2019, IDF DIABETES ATLAS
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Katoh K, 2002, NUCLEIC ACIDS RES, V30, P3059, DOI 10.1093/nar/gkf436
   Katoh K, 2013, MOL BIOL EVOL, V30, P772, DOI 10.1093/molbev/mst010
   Kembel SW, 2010, BIOINFORMATICS, V26, P1463, DOI 10.1093/bioinformatics/btq166
   Keohane DM, 2020, NAT MED, V26, P1089, DOI 10.1038/s41591-020-0963-8
   Koh A, 2018, CELL, V175, P947, DOI 10.1016/j.cell.2018.09.055
   Kozich JJ, 2013, APPL ENVIRON MICROB, V79, P5112, DOI 10.1128/AEM.01043-13
   Krautkramer KA, 2021, NAT REV MICROBIOL, V19, P77, DOI 10.1038/s41579-020-0438-4
   Le Chatelier E, 2013, NATURE, V500, P541, DOI 10.1038/nature12506
   Li RF, 2021, FRONT MICROBIOL, V11, DOI 10.3389/fmicb.2020.555293
   Louis P, 2017, ENVIRON MICROBIOL, V19, P29, DOI 10.1111/1462-2920.13589
   Lozupone C, 2005, APPL ENVIRON MICROB, V71, P8228, DOI 10.1128/AEM.71.12.8228-8235.2005
   Lundberg SM, 2020, NAT MACH INTELL, V2, P56, DOI 10.1038/s42256-019-0138-9
   Lynch SV, 2016, NEW ENGL J MED, V375, P2369, DOI 10.1056/NEJMra1600266
   Magruder M, 2020, GUT MICROBES, V12, DOI 10.1080/19490976.2020.1805281
   McMurdie PJ, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0061217
   Meeks KAC, 2016, INTERN EMERG MED, V11, P327, DOI 10.1007/s11739-015-1302-9
   Meinshausen N, 2010, J R STAT SOC B, V72, P417, DOI 10.1111/j.1467-9868.2010.00740.x
   Mobini R, 2017, DIABETES OBES METAB, V19, P579, DOI 10.1111/dom.12861
   Muilwijk M, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-56596-4
   Oksanen Jari, 2020, CRAN
   Paradis E, 2019, BIOINFORMATICS, V35, P526, DOI 10.1093/bioinformatics/bty633
   Pearce N, 2016, BMJ-BRIT MED J, V352, DOI 10.1136/bmj.i969
   Pedersen HK, 2016, NATURE, V535, P376, DOI 10.1038/nature18646
   Price MN, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009490
   Pushpanathan Premalatha, 2016, Indian J Endocrinol Metab, V20, P523, DOI 10.4103/2230-8210.183474
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Quast C, 2013, NUCLEIC ACIDS RES, V41, pD590, DOI 10.1093/nar/gks1219
   R Core Team, 2022, R LANG ENV STAT COMP
   Revelle W., PSYCH PROCEDURES PER
   Snijder MB, 2017, BMJ OPEN, V7, DOI 10.1136/bmjopen-2017-017873
   Snijder MB, 2017, J DIABETES RES, V2017, DOI 10.1155/2017/9896849
   Stronks K, 2013, BMC PUBLIC HEALTH, V13, DOI 10.1186/1471-2458-13-402
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Therdtatha P, 2021, MICROORGANISMS, V9, DOI 10.3390/microorganisms9050897
   Tillin T, 2013, DIABETES CARE, V36, P383, DOI 10.2337/dc12-0544
   Vangay P, 2018, CELL, V175, P962, DOI 10.1016/j.cell.2018.10.029
   Verhaar BJH, 2020, EUR HEART J, V41, P4259, DOI 10.1093/eurheartj/ehaa704
   Vieira-Silva S, 2020, NATURE, V581, P310, DOI 10.1038/s41586-020-2269-x
   Vila AV, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-019-14177-z
   Vojinovic D, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-13721-1
   Vujkovic-Cvijin I, 2020, NATURE, V587, P448, DOI 10.1038/s41586-020-2881-9
   Wang JJ, 2020, J DIABETES RES, V2020, DOI 10.1155/2020/6047145
   Wang Y, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0172774
   Wu H, 2020, CELL METAB, V32, P379, DOI 10.1016/j.cmet.2020.06.011
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Zeevi D, 2019, NATURE, V568, P43, DOI 10.1038/s41586-019-1065-y
   Zhong HZ, 2019, EBIOMEDICINE, V47, P373, DOI 10.1016/j.ebiom.2019.08.048
NR 74
TC 9
Z9 9
U1 1
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD SEP
PY 2021
VL 13
IS 9
AR 3289
DI 10.3390/nu13093289
PG 23
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA UY6AQ
UT WOS:000701604700001
PM 34579166
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Wu, JY
   Wang, K
   Wang, XM
   Pang, YL
   Jiang, CT
AF Wu, Jiayu
   Wang, Kai
   Wang, Xuemei
   Pang, Yanli
   Jiang, Changtao
TI The role of the gut microbiome and its metabolites in metabolic diseases
SO PROTEIN & CELL
LA English
DT Review
DE gut microbiome; metabolism; metabolite; immune regulation; metabolic
   diseases
ID FATTY LIVER-DISEASE; IMPAIRED GLUCOSE-TOLERANCE; BILE-ACID METABOLISM;
   INTESTINAL MICROBIOTA; ADIPOSE-TISSUE; METFORMIN ALTERS; FASTING
   GLUCOSE; OBESITY; RECEPTOR; MODULATION
AB It is well known that an unhealthy lifestyle is a major risk factor for metabolic diseases, while in recent years, accumulating evidence has demonstrated that the gut microbiome and its metabolites also play a crucial role in the onset and development of many metabolic diseases, including obesity, type 2 diabetes, nonalcoholic fatty liver disease, cardiovascular disease and so on. Numerous microorganisms dwell in the gastrointestinal tract, which is a key interface for energy acquisition and can metabolize dietary nutrients into many bioactive substances, thus acting as a link between the gut microbiome and its host. The gut microbiome is shaped by host genetics, immune responses and dietary factors. The metabolic and immune potential of the gut microbiome determines its significance in host health and diseases. Therefore, targeting the gut microbiome and relevant metabolic pathways would be effective therapeutic treatments for many metabolic diseases in the near future. This review will summarize information about the role of the gut microbiome in organism metabolism and the relationship between gut microbiome-derived metabolites and the pathogenesis of many metabolic diseases. Furthermore, recent advances in improving metabolic diseases by regulating the gut microbiome will be discussed.
C1 [Wu, Jiayu; Wang, Kai; Wang, Xuemei; Pang, Yanli; Jiang, Changtao] Peking Univ Third Hosp, Sch Basic Med Sci, Dept Obstet & Gynecol, Ctr Obes & Metab Dis Res, Beijing 100191, Peoples R China.
   [Wu, Jiayu; Wang, Kai; Wang, Xuemei; Jiang, Changtao] Peking Univ Third Hosp, Inst Med Innovat & Res, Ctr Basic Med Res, Beijing 100191, Peoples R China.
   [Wu, Jiayu; Wang, Kai; Wang, Xuemei; Jiang, Changtao] Peking Univ, Sch Basic Med Sci, Dept Physiol & Pathophysiol, Key Lab Mol Cardiovasc Sci,Minist Educ, Beijing 100191, Peoples R China.
C3 Peking University
RP Jiang, CT (通讯作者)，Peking Univ Third Hosp, Sch Basic Med Sci, Dept Obstet & Gynecol, Ctr Obes & Metab Dis Res, Beijing 100191, Peoples R China.; Jiang, CT (通讯作者)，Peking Univ Third Hosp, Inst Med Innovat & Res, Ctr Basic Med Res, Beijing 100191, Peoples R China.; Jiang, CT (通讯作者)，Peking Univ, Sch Basic Med Sci, Dept Physiol & Pathophysiol, Key Lab Mol Cardiovasc Sci,Minist Educ, Beijing 100191, Peoples R China.
EM jiangchangtao@bjmu.edu.cn
RI Wang, Xuemei/GXF-3702-2022; cell, protein/HSI-1531-2023; Wang,
   Kai/GPT-2392-2022
OI Wang, Kai/0000-0001-9705-6366; Jiang, Changtao/0000-0002-5206-2372
FU National Key Research and Development Program of China [2018YFA0800700,
   2018YFC1003200]; National Natural Science Foundation of the P. R. of
   China [91857115, 31925021, 81921001]
FX This work was supported by the National Key Research and Development
   Program of China (2018YFA0800700 and 2018YFC1003200) and the National
   Natural Science Foundation of the P. R. of China (No. 91857115,
   31925021, and 81921001).
CR Al-Lahham SH, 2010, EUR J CLIN INVEST, V40, P401, DOI 10.1111/j.1365-2362.2010.02278.x
   Albaugh VL, 2019, GASTROENTEROLOGY, V156, P1041, DOI 10.1053/j.gastro.2018.11.017
   Albenberg LG, 2014, GASTROENTEROLOGY, V146, P1564, DOI 10.1053/j.gastro.2014.01.058
   Aron-Wisnewsky J, 2020, GASTROENTEROLOGY, V158, P1881, DOI 10.1053/j.gastro.2020.01.049
   Bain CC, 2020, IMMUNOLOGY, V159, P1, DOI 10.1111/imm.13159
   Bauer PV, 2018, CELL METAB, V27, P101, DOI 10.1016/j.cmet.2017.09.019
   Brandhorst S, 2019, CIRC RES, V124, P952, DOI 10.1161/CIRCRESAHA.118.313352
   Canfora EE, 2019, NAT REV ENDOCRINOL, V15, P261, DOI 10.1038/s41574-019-0156-z
   Chang PV, 2014, P NATL ACAD SCI USA, V111, P2247, DOI 10.1073/pnas.1322269111
   Corpeleijn E, 2009, OBES REV, V10, P178, DOI 10.1111/j.1467-789X.2008.00544.x
   CUMMINGS JH, 1987, GUT, V28, P1221, DOI 10.1136/gut.28.10.1221
   Da Silva HE, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-19753-9
   David LA, 2014, NATURE, V505, P559, DOI 10.1038/nature12820
   de Cabo R, 2019, NEW ENGL J MED, V381, P2541, DOI 10.1056/NEJMra1905136
   de Vegt F, 2001, JAMA-J AM MED ASSOC, V285, P2109, DOI 10.1001/jama.285.16.2109
   Di Francesco A, 2018, SCIENCE, V362, P770, DOI 10.1126/science.aau2095
   Duboc H, 2014, DIGEST LIVER DIS, V46, P302, DOI 10.1016/j.dld.2013.10.021
   Eloe-Fadrosh EA, 2015, MBIO, V6, DOI 10.1128/mBio.00231-15
   Enck K, 2020, CURR PHARM DESIGN, V26, P3134, DOI 10.2174/1381612826666200210111925
   Ferrario C, 2014, J NUTR, V144, P1787, DOI 10.3945/jn.114.197723
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Frost G, 2014, NAT COMMUN, V5, DOI 10.1038/ncomms4611
   Fu T, 2019, CELL, V176, P1098, DOI 10.1016/j.cell.2019.01.036
   Funabashi M, 2020, NATURE, V582, P566, DOI 10.1038/s41586-020-2396-4
   Gibson GR, 2017, NAT REV GASTRO HEPAT, V14, P491, DOI 10.1038/nrgastro.2017.75
   Gilbert JA, 2018, NAT MED, V24, P392, DOI 10.1038/nm.4517
   Grundy SM, 2012, J AM COLL CARDIOL, V59, P635, DOI 10.1016/j.jacc.2011.08.080
   Gu YY, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-01682-2
   Guo CJ, 2019, SCIENCE, V366, P1331, DOI 10.1126/science.aav1282
   Guo Y, 2016, PLASMONICS, V11, P11, DOI [10.1007/s11468-015-0008-1, 10.1371/journal.pone.0156323]
   Hang SY, 2019, NATURE, V576, P143, DOI 10.1038/s41586-019-1785-z
   Hatori M, 2012, CELL METAB, V15, P848, DOI 10.1016/j.cmet.2012.04.019
   Heymsfield SB, 2017, NEW ENGL J MED, V376, P254, DOI 10.1056/NEJMra1514009
   Huang FJ, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-12896-x
   Huang ZR, 2020, J AGR FOOD CHEM, V68, P6530, DOI 10.1021/acs.jafc.9b08211
   Islam KBMS, 2011, GASTROENTEROLOGY, V141, P1773, DOI 10.1053/j.gastro.2011.07.046
   Jandhyala SM, 2015, WORLD J GASTROENTERO, V21, P8787, DOI 10.3748/wjg.v21.i29.8787
   Jiang CT, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms10166
   Kars M, 2010, DIABETES, V59, P1899, DOI 10.2337/db10-0308
   Kelley ST, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0146509
   Kim DH, 2015, DRUG METAB DISPOS, V43, P1581, DOI 10.1124/dmd.115.063867
   Knowler WC, 2002, NEW ENGL J MED, V346, P393, DOI 10.1056/NEJMoa012512
   Kovatcheva-Datchary P, 2015, CELL METAB, V22, P971, DOI 10.1016/j.cmet.2015.10.001
   Kristensen NB, 2016, GENOME MED, V8, DOI 10.1186/s13073-016-0300-5
   Larraufie P, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-017-18259-0
   Larsson H, 2000, DIABETOLOGIA, V43, P1224, DOI 10.1007/s001250051516
   Laursen MF, 2017, BMC MICROBIOL, V17, DOI 10.1186/s12866-017-1090-7
   Le Roy T, 2013, GUT, V62, P1787, DOI 10.1136/gutjnl-2012-303816
   Levy M, 2015, CELL, V163, P1428, DOI 10.1016/j.cell.2015.10.048
   Li GL, 2017, CELL METAB, V26, P672, DOI 10.1016/j.cmet.2017.08.019
   Li Z, 2018, GUT, V67, P1269, DOI 10.1136/gutjnl-2017-314050
   Lim PS, 2020, J APPL MICROBIOL, V129, P1374, DOI 10.1111/jam.14678
   Lindheim L, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0168390
   Liu R, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.00324
   Liu RX, 2017, NAT MED, V23, P859, DOI 10.1038/nm.4358
   Longo VD, 2016, CELL METAB, V23, P1048, DOI 10.1016/j.cmet.2016.06.001
   Louis P, 2014, NAT REV MICROBIOL, V12, P661, DOI 10.1038/nrmicro3344
   Manco M, 2010, ENDOCR REV, V31, P817, DOI 10.1210/er.2009-0030
   Mao KR, 2018, NATURE, V554, P255, DOI 10.1038/nature25437
   Matsubara T, 2013, MOL CELL ENDOCRINOL, V368, P17, DOI 10.1016/j.mce.2012.05.004
   Meslier V, 2020, GUT, V69, P1258, DOI 10.1136/gutjnl-2019-320438
   Miyamoto J, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-11978-0
   Nathan DM, 2007, DIABETES CARE, V30, P753, DOI 10.2337/dc07-9920
   Norman RJ, 2007, LANCET, V370, P685, DOI 10.1016/S0140-6736(07)61345-2
   Perez-Munoz ME, 2017, MICROBIOME, V5, DOI 10.1186/s40168-017-0268-4
   Pi Y, 2020, MSYSTEMS, V5, DOI 10.1128/mSystems.00176-20
   Popkin BM, 2012, NUTR REV, V70, P3, DOI 10.1111/j.1753-4887.2011.00456.x
   Psichas A, 2015, INT J OBESITY, V39, P424, DOI 10.1038/ijo.2014.153
   Qi XY, 2019, NAT MED, V25, P1225, DOI 10.1038/s41591-019-0509-0
   Quinn RA, 2020, NATURE, V579, P123, DOI 10.1038/s41586-020-2047-9
   Ragsdale SW, 2008, BBA-PROTEINS PROTEOM, V1784, P1873, DOI 10.1016/j.bbapap.2008.08.012
   Rao RK, 2004, AM J PHYSIOL-GASTR L, V286, pG881, DOI 10.1152/ajpgi.00006.2004
   Reilly SM, 2017, NAT REV ENDOCRINOL, V13, P633, DOI 10.1038/nrendo.2017.90
   Rosamond W, 2008, CIRCULATION, V117, pE25, DOI 10.1161/CIRCULATIONAHA.107.187998
   Rubio LA, 2020, FOODS, V9, DOI 10.3390/foods9060704
   Sanna S, 2019, NAT GENET, V51, P600, DOI 10.1038/s41588-019-0350-x
   Santaguida P L, 2005, Evid Rep Technol Assess (Summ), P1
   Schroeder B, 2016, NAT MED, V22, P1079, DOI 10.1038/nm.4185
   Schwimmer JB, 2019, GASTROENTEROLOGY, V157, P1109, DOI 10.1053/j.gastro.2019.06.028
   Sender R, 2016, CELL, V164, P337, DOI 10.1016/j.cell.2016.01.013
   Shaw JA, 1999, DIABETES CARE, V22, P399, DOI 10.2337/diacare.22.3.399
   Song XY, 2020, NATURE, V577, P410, DOI 10.1038/s41586-019-1865-0
   Sun J, 2016, BRIT J NUTR, V115, P1167, DOI 10.1017/S0007114516000076
   Sun LL, 2019, ACTA PHARM SIN B, V9, P702, DOI 10.1016/j.apsb.2019.02.004
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Sutton EF, 2018, CELL METAB, V27, P1212, DOI 10.1016/j.cmet.2018.04.010
   Swann JR, 2011, P NATL ACAD SCI USA, V108, P4523, DOI 10.1073/pnas.1006734107
   Thingholm LB, 2019, CELL HOST MICROBE, V26, P252, DOI 10.1016/j.chom.2019.07.004
   Tolhurst G, 2012, DIABETES, V61, P364, DOI 10.2337/db11-1019
   Trabelsi MS, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms8629
   Tuomilehto J, 2001, NEW ENGL J MED, V344, P1343, DOI 10.1056/NEJM200105033441801
   Turnbaugh PJ, 2008, CELL HOST MICROBE, V3, P213, DOI 10.1016/j.chom.2008.02.015
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Usami M, 2008, NUTR RES, V28, P321, DOI 10.1016/j.nutres.2008.02.012
   Vendrame F, 2004, ENDOCRIN METAB CLIN, V33, P75, DOI 10.1016/j.ecl.2003.12.006
   VERNOCCHI P, 2016, FRONT MICROBIOL, V7
   Wang BH, 2016, SCI REP-UK, V6, DOI 10.1038/srep32002
   Wang CX, 2015, ANN NUTR METAB, V67, P257, DOI 10.1159/000441066
   Wang LF, 2020, BBA-MOL BASIS DIS, V1866, DOI 10.1016/j.bbadis.2020.165908
   Whang A, 2019, EBIOMEDICINE, V39, P591, DOI 10.1016/j.ebiom.2018.11.046
   Whitman WB, 1998, P NATL ACAD SCI USA, V95, P6578, DOI 10.1073/pnas.95.12.6578
   Worthmann A, 2017, NAT MED, V23, P839, DOI 10.1038/nm.4357
   Wu GD, 2011, SCIENCE, V334, P105, DOI 10.1126/science.1208344
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Xie C, 2017, DIABETES, V66, P613, DOI 10.2337/db16-0663
   Yao CK, 2016, ALIMENT PHARM THER, V43, P181, DOI 10.1111/apt.13456
   Younossi ZM, 2015, HEPATOLOGY, V62, p739A
   Zeevi D, 2015, CELL, V163, P1079, DOI 10.1016/j.cell.2015.11.001
   Zelante T, 2013, IMMUNITY, V39, P372, DOI 10.1016/j.immuni.2013.08.003
   Zhang LM, 2016, MSYSTEMS, V1, DOI 10.1128/mSystems.00070-16
   Zhang Qing, 2015, Zhongguo Zhong Yao Za Zhi, V40, P1660
   Zhang W, 2019, BIOMED PHARMACOTHER, V118, DOI 10.1016/j.biopha.2019.109131
   Zhang XZ, 2019, CELL METAB, V30, P937, DOI 10.1016/j.cmet.2019.09.016
   ZHANG Z, 2020, BR J NUTR
   Zheng Y, 2018, NAT REV ENDOCRINOL, V14, P88, DOI 10.1038/nrendo.2017.151
   Zhu LX, 2013, HEPATOLOGY, V57, P601, DOI 10.1002/hep.26093
NR 116
TC 85
Z9 90
U1 23
U2 98
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1674-800X
EI 1674-8018
J9 PROTEIN CELL
JI Protein Cell
PD MAY
PY 2021
VL 12
IS 5
SI SI
BP 360
EP 373
DI 10.1007/s13238-020-00814-7
EA DEC 2020
PG 14
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA RZ1WK
UT WOS:000600826500001
PM 33346905
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Jacob, S
   Dotsch, A
   Knoll, S
   Kohler, HR
   Rogall, E
   Stoll, D
   Tisler, S
   Huhn, C
   Schwartz, T
   Zwiener, C
   Triebskorn, R
AF Jacob, Stefanie
   Doetsch, Andreas
   Knoll, Sarah
   Koehler, Heinz-R.
   Rogall, Eike
   Stoll, Dominic
   Tisler, Selina
   Huhn, Carolin
   Schwartz, Thomas
   Zwiener, Christian
   Triebskorn, Rita
TI Does the antidiabetic drug metformin affect embryo development and the
   health of brown trout (Salmo trutta f. fario)?
SO ENVIRONMENTAL SCIENCES EUROPE
LA English
DT Article
DE Pharmaceutical; Salmonid; Glycogen; Body weight; Microbiome
ID PERSONAL CARE PRODUCTS; CLINICAL PHARMACOKINETICS; TRANSFORMATION
   PRODUCTS; LIVER ULTRASTRUCTURE; ENDOCRINE DISRUPTION; RAINBOW-TROUT;
   WASTE-WATER; WEIGHT-LOSS; PART II; PHARMACEUTICALS
AB BackgroundDue to the rising number of type 2 diabetes patients, the antidiabetic drug, metformin is currently among those pharmaceuticals with the highest consumption rates worldwide. Via sewage-treatment plants, metformin enters surface waters where it is frequently detected in low concentrations (mu g/L). Since possible adverse effects of this substance in aquatic organisms have been insufficiently explored to date, the aim of this study was to investigate the impact of metformin on health and development in brown trout (Salmo trutta f. fario) and its microbiome.ResultsBrown trout embryos were exposed to 0, 1, 10, 100 and 1000 mu g/L metformin over a period from 48days post fertilisation (dpf) until 8weeks post-yolksac consumption at 7 degrees C (156dpf) and 11 degrees C (143dpf). Chemical analyses in tissues of exposed fish showed the concentration-dependent presence of metformin in the larvae. Mortality, embryonic development, body length, liver tissue integrity, stress protein levels and swimming behaviour were not influenced. However, compared to the controls, the amount of hepatic glycogen was higher in larvae exposed to metformin, especially in fish exposed to the lowest metformin concentration of 1 mu g/L, which is environmentally relevant. At higher metformin concentrations, the glycogen content in the liver showed a high variability, especially for larvae exposed to 1000 mu g/L metformin. Furthermore, the body weight of fish exposed to 10 and 100 mu g/L metformin at 7 degrees C and to 1 mu g/L metformin at 11 degrees C was decreased compared with the respective controls. The results of the microbiome analyses indicated a shift in the bacteria distribution in fish exposed to 1 and 10 mu g/L metformin at 7 degrees C and to 100 mu g/L metformin at 11 degrees C, leading to an increase of Proteobacteria and a reduction of Firmicutes and Actinobacteria.ConclusionsOverall, weight reduction and the increased glycogen content belong to the described pharmaceutical effects of the drug in humans, but this study showed that they also occur in brown trout larvae. The impact of a shift in the intestinal microbiome caused by metformin on the immune system and vitality of the host organism should be the subject of further research before assessing the environmental relevance of the pharmaceutical.
C1 [Jacob, Stefanie; Koehler, Heinz-R.; Triebskorn, Rita] Univ Tubingen, Anim Physiol Ecol, Morgenstelle 5, D-72076 Tubingen, Germany.
   [Doetsch, Andreas] Max Rubner Inst, Dept Physiol & Biochem Nutr, Haid & Neu Str 9, D-76131 Karlsruhe, Germany.
   [Stoll, Dominic] Max Rubner Inst, Dept Safety & Qual Fruit & Vegetables, Haid & Neu Str 9, D-76131 Karlsruhe, Germany.
   [Knoll, Sarah; Huhn, Carolin] Univ Tubingen, Effect Based Environm Anal, Morgenstelle 18, D-72076 Tubingen, Germany.
   [Doetsch, Andreas; Rogall, Eike; Schwartz, Thomas] Karlsruhe Inst Technol, Interface Microbiol, Hermann von Helmholtz Pl 1, D-76344 Eggenstein Leopoldshafen, Germany.
   [Tisler, Selina; Zwiener, Christian] Univ Tubingen, Environm Analyt Chem, Holderlinstr 12, D-72074 Tubingen, Germany.
   [Triebskorn, Rita] Steinbeis Transfer Ctr Ecotoxicol & Ecophysiol, Blumenstr 13, D-72108 Rottenburg, Germany.
C3 Eberhard Karls University of Tubingen; Eberhard Karls University of
   Tubingen; Helmholtz Association; Karlsruhe Institute of Technology;
   Eberhard Karls University of Tubingen
RP Jacob, S (通讯作者)，Univ Tubingen, Anim Physiol Ecol, Morgenstelle 5, D-72076 Tubingen, Germany.
EM stefanie.jacob@uni-tuebingen.de
RI Köhler, Heinz-R./AAL-1350-2021; Zwiener, Christian/U-2155-2019; Tisler,
   Selina/GLV-5417-2022; Dötsch, Andreas/H-1383-2013
OI Zwiener, Christian/0000-0002-6682-5828; Dötsch,
   Andreas/0000-0001-9086-2584; Tisler, Selina/0000-0002-3366-7499; Jacob,
   Stefanie/0000-0003-3427-0706; Huhn, Carolin/0000-0001-6865-1043
FU Ministry for Science, Research and Arts of Baden-Wurttemberg
   [33-5733-25-11t32/2]
FX This study is funded by the Ministry for Science, Research and Arts of
   Baden-Wurttemberg (Grant No. 33-5733-25-11t32/2).
CR Aguera A, 2013, ENVIRON SCI POLLUT R, V20, P3496, DOI 10.1007/s11356-013-1586-0
   An HY, 2016, J ENDOCRINOL, V228, pR97, DOI 10.1530/JOE-15-0447
   [Anonymous], 1987, BIOL FISH GROWTH
   Bailey CJ, 2008, DIABETOLOGIA, V51, P1552, DOI 10.1007/s00125-008-1053-5
   BAILEY CJ, 1993, GEN PHARMACOL, V24, P1299, DOI 10.1016/0306-3623(93)90411-P
   BARTON BA, 1987, AQUACULTURE, V62, P299, DOI 10.1016/0044-8486(87)90172-4
   BECKMANN R, 1969, DIABETOLOGIA, V5, P318, DOI 10.1007/BF00452906
   BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
   BRAUNBECK T, 1990, ARCH ENVIRON CON TOX, V19, P405, DOI 10.1007/BF01054986
   Camarinha-Silva A, 2014, ENVIRON MICROBIOL, V16, P2939, DOI 10.1111/1462-2920.12362
   Chung H, 2018, PLOS ONE, V13, DOI [10.1371/journal.pone.0191258, 10.1371/Journal.pone.0191258]
   Cleuvers M, 2003, TOXICOL LETT, V142, P185, DOI 10.1016/S0378-4274(03)00068-7
   Crago J, 2016, GEN COMP ENDOCR, V232, P185, DOI 10.1016/j.ygcen.2015.12.030
   Cusi K, 1996, J CLIN ENDOCR METAB, V81, P4059, DOI 10.1210/jc.81.11.4059
   Daughton CG, 1999, ENVIRON HEALTH PERSP, V107, P907, DOI 10.2307/3434573
   de Vos WM, 2012, NUTR REV, V70, pS45, DOI 10.1111/j.1753-4887.2012.00505.x
   der Beek TA, 2016, ENVIRON TOXICOL CHEM, V35, P823, DOI 10.1002/etc.3339
   Dieterich A, 2015, CELL STRESS CHAPERON, V20, P159, DOI 10.1007/s12192-014-0534-3
   El-Mir MY, 2000, J BIOL CHEM, V275, P223, DOI 10.1074/jbc.275.1.223
   EMA, 2011, ASS REPORTJENTADUETO
   Foretz M, 2014, CELL METAB, V20, P953, DOI 10.1016/j.cmet.2014.09.018
   Foretz M, 2010, J CLIN INVEST, V120, P2355, DOI 10.1172/JCI40671
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Ghoshdastidar AJ, 2015, ENVIRON SCI POLLUT R, V22, P689, DOI 10.1007/s11356-014-3400-z
   Giannarelli R, 2003, DIABETES METAB, V29, pS28
   Godoy AA, 2018, ENVIRON POLLUT, V243, P534, DOI 10.1016/j.envpol.2018.09.031
   Graham GG, 2011, CLIN PHARMACOKINET, V50, P81, DOI 10.2165/11534750-000000000-00000
   Hari RE, 2006, GLOBAL CHANGE BIOL, V12, P10, DOI 10.1111/j.1365-2486.2005.001051.x
   Hawley SA, 2010, CELL METAB, V11, P554, DOI 10.1016/j.cmet.2010.04.001
   HUNDAL HS, 1992, ENDOCRINOLOGY, V131, P1165, DOI 10.1210/en.131.3.1165
   Janssens Y, 2018, BMC MICROBIOL, V18, DOI 10.1186/s12866-018-1197-5
   Jones OAH, 2002, WATER RES, V36, P5013, DOI 10.1016/S0043-1354(02)00227-0
   Kasprzyk-Hordern B, 2008, WATER RES, V42, P3498, DOI 10.1016/j.watres.2008.04.026
   Khan S, 2002, OCCURRENCE DISTRIBUT
   Killeen J, 1999, J FISH BIOL, V55, P382, DOI 10.1006/jfbi.1999.1004
   Kozich JJ, 2013, APPL ENVIRON MICROB, V79, P5112, DOI 10.1128/AEM.01043-13
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   LINDQUIST S, 1986, ANNU REV BIOCHEM, V55, P1151, DOI 10.1146/annurev.bi.55.070186.005443
   Lord JM, 2003, BRIT MED J, V327, P951, DOI 10.1136/bmj.327.7421.951
   Malin SK, 2014, CURR OPIN ENDOCRINOL, V21, P323, DOI 10.1097/MED.0000000000000095
   Marchesi JR, 2016, GUT, V65, P330, DOI 10.1136/gutjnl-2015-309990
   Martin-Castillo B, 2010, CELL CYCLE, V9, P1057, DOI 10.4161/cc.9.6.10994
   MATTHAEI S, 1993, ENDOCRINOLOGY, V133, P304, DOI 10.1210/en.133.1.304
   Moermond CTA, 2016, ENVIRON TOXICOL CHEM, V35, P1297, DOI 10.1002/etc.3259
   Moermond CTA, 2016, ENVIRON TOXICOL CHEM, V35, P882, DOI 10.1002/etc.3178
   Murtha JM, 2003, EXP GERONTOL, V38, P683, DOI 10.1016/S0531-5565(03)00067-6
   Natali A, 2006, DIABETOLOGIA, V49, P434, DOI 10.1007/s00125-006-0141-7
   Nestler JE, 2008, NEW ENGL J MED, V358, P47, DOI 10.1056/NEJMct0707092
   Niemuth NJ, 2018, AQUAT TOXICOL, V195, P33, DOI 10.1016/j.aquatox.2017.12.003
   Niemuth NJ, 2015, CHEMOSPHERE, V135, P38, DOI 10.1016/j.chemosphere.2015.03.060
   Niemuth NJ, 2015, ENVIRON TOXICOL CHEM, V34, P291, DOI 10.1002/etc.2793
   Paleari L, 2018, GASTROENTEROLOGY, V154, P1543, DOI 10.1053/j.gastro.2017.12.040
   Peragon J, 2001, INT J BIOCHEM CELL B, V33, P1227, DOI 10.1016/S1357-2725(01)00088-7
   Piro S, 2012, J ENDOCRINOL INVEST, V35, P504, DOI 10.3275/7866
   Pollak M, 2017, DIABETOLOGIA, V60, P1662, DOI 10.1007/s00125-017-4352-x
   Quast C, 2013, NUCLEIC ACIDS RES, V41, pD590, DOI 10.1093/nar/gks1219
   Ringo E, 1999, AQUAC RES, V30, P73, DOI 10.1046/j.1365-2109.1999.00302.x
   Ringo E, 2001, J APPL MICROBIOL, V90, P294, DOI 10.1046/j.1365-2672.2001.01246.x
   Rognes T, 2016, PEERJ, V4, DOI 10.7717/peerj.2584
   Scheen AJ, 1996, CLIN PHARMACOKINET, V30, P359, DOI 10.2165/00003088-199630050-00003
   Scheurer M, 2012, WATER RES, V46, P4790, DOI 10.1016/j.watres.2012.06.019
   Schloss PD, 2009, APPL ENVIRON MICROB, V75, P7537, DOI 10.1128/AEM.01541-09
   Schramm M, 1998, BIOMARKERS, V3, P93, DOI 10.1080/135475098231264
   Schwabe U., 2016, ARZNEIVERORDNUNGS RE
   Schwarzenbach RP, 2006, SCIENCE, V313, P1072, DOI 10.1126/science.1127291
   Seifarth C, 2013, EXP CLIN ENDOCR DIAB, V121, P27, DOI 10.1055/s-0032-1327734
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Tisler S, 2018, SCI TOTAL ENVIRON, V628-629, P1121, DOI 10.1016/j.scitotenv.2018.02.105
   TOCRIS, 2017, SAF DAT SHEET METF H
   Trautwein C, 2011, CHEMOSPHERE, V85, P765, DOI 10.1016/j.chemosphere.2011.06.057
   Triebskorn R, 2004, AQUAT TOXICOL, V68, P151, DOI 10.1016/j.aquatox.2004.03.015
   Triebskorn R, 2008, ENVIRON MONIT ASSESS, V141, P177, DOI 10.1007/s10661-007-9886-9
   Ussery E, 2018, ECOTOXICOLOGICAL EFF
   Wiernsperger NF, 1999, DRUGS, V58, P31, DOI 10.2165/00003495-199958001-00009
   WILCOCK C, 1994, XENOBIOTICA, V24, P49, DOI 10.3109/00498259409043220
   Wu H, 2017, NAT MED, DOI [10.1038/nm.4345`1, DOI 10.1038/NM.4345`1]
   Wu H, 2015, TRENDS ENDOCRIN MET, V26, P758, DOI 10.1016/j.tem.2015.09.011
NR 77
TC 20
Z9 20
U1 2
U2 15
PU SPRINGEROPEN
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 2190-4715
J9 ENVIRON SCI EUR
JI Environ. Sci Eur.
PD DEC 7
PY 2018
VL 30
AR 48
DI 10.1186/s12302-018-0179-4
PG 16
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA HD8CD
UT WOS:000452781000001
PM 30595998
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU He, HY
   Liu, MT
   He, R
   Zhao, W
AF He, Haiyan
   Liu, Mengting
   He, Rong
   Zhao, Wei
TI Lipid-lowering activity of metformin-soluble soybean polysaccharide
   nanoparticles
SO FOOD & FUNCTION
LA English
DT Article
ID GUT MICROBIOTA; METABOLISM
AB Soybean dregs are one of the most important albeit underutilized byproducts in soybean processing. In this study, soluble soybean polysaccharides with lipid-lowering activity were extracted from soybean dregs and used as a wall material for embedding metformin. Metformin-soluble soybean polysaccharide nanoparticles (MET-SSPS-NPs) were prepared by electrostatic interaction. The lipid-lowering activity and possible mechanism of MET-SSPS-NPs were investigated. Western blotting was used to detect the expression levels of cell-related protein proprotein convertase subtilisin/kexin type 9 (PCSK9) and low-density lipoprotein receptor (LDLR) in vitro. The results showed that MET-SSPS-NPs lowered the expression of PCSK9 and improved LDLR levels. A high-fat diet (HFD) animal model was established to study the lipid-lowering effect of MET-SSPS-NPs by real-time quantitative PCR and western blotting. MET-SSPS-NPs significantly upregulated peroxisome proliferator-activated receptor gamma (PPAR gamma) expression and downregulated PCSK9, fatty acid-binding protein (FABP)7 and FABP5 expression more strongly than MET or SSPS alone. In conclusion, MET-SSPS-NPs can inhibit PCSK9 expression and improve the level of adipokines, providing a theoretical basis for the application of MET-SSPS-NPs in lipid lowering.
C1 [He, Haiyan; Zhao, Wei] Jiangnan Univ, Sch Food Sci & Technol, Wuxi 214122, Jiangsu, Peoples R China.
   [He, Haiyan] Jiangsu Vocat Inst Commerce, Hlth Coll, Nanjing 211168, Peoples R China.
   [Liu, Mengting; He, Rong] Nanjing Univ Finance & Econ, Key Lab Grains & Oils Qual Control & Proc, Collaborat Innovat Ctr Modern Grain Circulat & Sa, Coll Food Sci & Engn, Nanjing 210023, Peoples R China.
C3 Jiangnan University; Jiangsu Vocational Institute of Commerce; Nanjing
   University of Finance & Economics
RP Zhao, W (通讯作者)，Jiangnan Univ, Sch Food Sci & Technol, Wuxi 214122, Jiangsu, Peoples R China.
EM zhaow@jiangnan.edu.cn
RI zhao, wei/IQS-1144-2023
OI he, rong/0000-0002-3341-9786; Zhao, Wei/0000-0001-9495-8508
FU JVIC Fund for Distinguished Young Scholars
FX Funding for this work was provided by the JVIC Fund for Distinguished
   Young Scholars.
CR Ahmad Z, 2014, AM J CARDIOL, V113, P1765, DOI 10.1016/j.amjcard.2014.02.033
   Ali A, 2022, ENDOCRINE, V76, P543, DOI 10.1007/s12020-022-03022-x
   Angelakis E, 2012, FUTURE MICROBIOL, V7, P91, DOI [10.2217/FMB.11.142, 10.2217/fmb.11.142]
   Beverly JK, 2020, J DIABETES, V12, P102, DOI 10.1111/1753-0407.12970
   Cao WX, 2020, INT J FOOD SCI NUTR, V71, P453, DOI 10.1080/09637486.2019.1686608
   Chakravarthy MV, 2005, CELL METAB, V1, P309, DOI 10.1016/j.cmet.2005.04.002
   Charan Reddy K.V., 2021, MED MICROECOL, V7, P100033, DOI [10.1016/j.medmic.2021.100033, DOI 10.1016/J.MEDMIC.2021.100033]
   Chen JZ, 2020, PHYS CHEM CHEM PHYS, V22, P2262, DOI 10.1039/c9cp05704h
   Chen SY, 2017, FASEB J, V31, P1085, DOI 10.1096/fj.201601022R
   Chen SC, 2017, MOL CELL ENDOCRINOL, V440, P57, DOI 10.1016/j.mce.2016.11.011
   Fei N, 2013, ISME J, V7, P880, DOI 10.1038/ismej.2012.153
   Ge XD, 2020, FOOD FUNCT, V11, P10033, DOI [10.1039/D0FO01840F, 10.1039/d0fo01840f]
   Gu LL, 2017, ONCOTARGET, V8, P80826, DOI 10.18632/oncotarget.20590
   Kaltenpoth M, 2009, TRENDS MICROBIOL, V17, P529, DOI 10.1016/j.tim.2009.09.006
   Klein-Szanto AJP, 2019, BIOCHEM PHARMACOL, V164, P336, DOI 10.1016/j.bcp.2019.04.003
   Lan Y, 2022, FOOD FUNCT, V13, P2925, DOI [10.1039/d1fo03147c, 10.1039/D1FO03147C]
   Li JJ, 2021, INT J BIOL MACROMOL, V182, P825, DOI 10.1016/j.ijbiomac.2021.04.070
   Li X, 2021, BIOMED PHARMACOTHER, V133, DOI 10.1016/j.biopha.2020.110802
   Lin XL, 2018, BIOMED PHARMACOTHER, V104, P36, DOI 10.1016/j.biopha.2018.05.024
   Liu H, 2023, CRIT REV FOOD SCI, V63, P330, DOI 10.1080/10408398.2021.1946480
   Liu H, 2020, FOOD FRONTIERS, V1, P45, DOI 10.1002/fft2.11
   Liu YY, 2020, FASEB J, V34, P1065, DOI 10.1096/fj.201901943RR
   Ma P, 2020, FOOD SCI NUTR, V8, P3212, DOI 10.1002/fsn3.1581
   Motawi TK, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-11180-6
   Ning YY, 2020, LIFE SCI, V262, DOI 10.1016/j.lfs.2020.118405
   Rymer JA, 2020, J AM HEART ASSOC, V9, DOI 10.1161/JAHA.119.014347
   Schulfer A, 2020, MSPHERE, V5, DOI 10.1128/mSphere.00833-19
   Seidah NG, 2021, J LIPID RES, V62, DOI 10.1016/j.jlr.2021.100130
   Shin NR, 2015, TRENDS BIOTECHNOL, V33, P496, DOI 10.1016/j.tibtech.2015.06.011
   Stephens RW, 2018, OBESITY, V26, P801, DOI 10.1002/oby.22179
   Su H, 2022, J SCI FOOD AGR, V102, P1598, DOI 10.1002/jsfa.11496
   Sui GG, 2018, J AGR FOOD CHEM, V66, P8983, DOI 10.1021/acs.jafc.8b02696
   Toth PP, 2017, J AM HEART ASSOC, V6, DOI 10.1161/JAHA.116.005367
   Uddandrao VVS, 2020, ARCH PHYSIOL BIOCHEM, V126, P453, DOI 10.1080/13813455.2018.1555668
   Wang ZG, 2015, FOOD BIOPROCESS TECH, V8, P1305, DOI 10.1007/s11947-015-1472-5
   Wu J, 2022, FOOD FUNCT, V13, P3023, DOI [10.1039/D1FO02165F, 10.1039/d1fo02165f]
   Xu Jie, 2020, Medicinal Plant, V11, P66, DOI 10.19600/j.cnki.issn2152-3924.2020.04.016
   Zamani-Garmsiri F, 2021, J NUTR BIOCHEM, V87, DOI 10.1016/j.jnutbio.2020.108505
   Zhang C, 2019, FOOD CHEM, V272, P694, DOI 10.1016/j.foodchem.2018.08.097
NR 39
TC 0
Z9 0
U1 12
U2 23
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD OCT 3
PY 2022
VL 13
IS 19
BP 10265
EP 10274
DI 10.1039/d2fo01237e
EA SEP 2022
PG 10
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA 5B1QN
UT WOS:000855404200001
PM 36125039
DA 2023-06-08
ER

PT J
AU Yang, M
   Shi, FH
   Liu, W
   Zhang, MC
   Feng, RL
   Qian, C
   Liu, W
   Ma, J
AF Yang, Mei
   Shi, Fang-Hong
   Liu, Wen
   Zhang, Min-Chun
   Feng, Ri-Lu
   Qian, Cheng
   Liu, Wei
   Ma, Jing
TI Dapagliflozin Modulates the Fecal Microbiota in a Type 2 Diabetic Rat
   Model
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE dapagliflozin; fecal microbiota; type 2 diabetes; metfomiin; high-fat
   diet
ID INTESTINAL MICROBIOTA; SGLT2 INHIBITION; METFORMIN ALTERS; GUT
   MICROBIOTA; CANAGLIFLOZIN
AB Background: The gut microbiota is recognized as a major modulator of metabolic disorders such as type 2 diabetes. Dapagliflozin, sodium glucose cotransporter 2 inhibitors (SGLT2i), enhances renal glucose excretion, and lowers blood glucose levels. The study aimed to determine the effects of dapagliflozin on fecal microbiota in a type 2 diabetic rat model.
   Methods: Four-week-old male Sprague Dawley rats (n = 24) were fed a high-fat diet (HFD) for 8 weeks and then given a single dose of STZ injection (30 mg/kg, i.p). They were randomly divided into three groups (n = 8). Each group received intragastric infusion of normal saline (2 ml, 0.9%) or metformin (215.15 mg/kg/day) or dapagliflozin (1 mg/kg/day) for 4 weeks. Blood glucose levels and plasma insulin levels were detected during intragastric glucose tolerance. Fecal samples were collected to access microbiome by 16S ribosomal RNA gene sequencing.
   Results: Dapagliflozin significantly decreased fasting and postprandial blood glucose levels as metformin in type 2 diabetic rats (P < 0.001). Enterotype was composed of Ruminococcaceae after treatment of dapagliflozin, whereas Ruminococcaceae and Muribaculaceae were the main enterotypes following metformin treatment. Dapagliflozin did not increase the abundance of beneficial bacteria including Lactobacillaceae and Bifidobacteriaceae. However, these were increased in the metformin group. It is surprising to find that Proteobacteria (especially Desulfovibrionaceae) were enriched in the dapagliflozin group.
   Conclusion: Dapagliflozin and metformin exerted complementary effects on the main beneficial bacteria. A combination of these two drugs might be beneficial to improve the structure of fecal microbiota in the treatment of type 2 diabetes.
C1 [Yang, Mei; Liu, Wen; Zhang, Min-Chun; Feng, Ri-Lu; Qian, Cheng; Liu, Wei; Ma, Jing] Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Dept Endocrinol & Metab, Shanghai, Peoples R China.
   [Shi, Fang-Hong] Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Dept Pharm, Shanghai, Peoples R China.
C3 Shanghai Jiao Tong University; Shanghai Jiao Tong University
RP Ma, J (通讯作者)，Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Dept Endocrinol & Metab, Shanghai, Peoples R China.
EM cherry1996@live.cn
RI Shi, Fang-Hong/AAP-9684-2020
FU National Natural Science Foundation of China [NSFC81670728]; Shanghai
   Municipal Education Commission-Gaofeng Clinical Medicine Grant Support
   [20181807]; Shanghai Pujiang Program [2019PJD027]; Shanghai Yangfan
   Program [19YF1428500]; Clinical Pharmacy Innovation Research Institute
   of Shanghai Jiao Tong University School of Medicine [CXYJY2019QN004];
   Research Funds of Shanghai Health and Family Planning Commission
   [20204Y0011]
FX This work was supported by the National Natural Science Foundation of
   China (grant number NSFC81670728), the Shanghai Municipal Education
   Commission-Gaofeng Clinical Medicine Grant Support (grant number
   20181807), the Shanghai Pujiang Program (2019PJD027), the Shanghai
   Yangfan Program (grant number 19YF1428500), the Clinical Pharmacy
   Innovation Research Institute of Shanghai Jiao Tong University School of
   Medicine (2019) (CXYJY2019QN004), and the Research Funds of Shanghai
   Health and Family Planning Commission (20204Y0011).
CR Aron-Wisnewsky J, 2019, CURR DIABETES REP, V19, DOI 10.1007/s11892-019-1180-z
   Arumugam M, 2011, NATURE, V473, P174, DOI 10.1038/nature09944
   Bauer PV, 2018, CELL METAB, V27, P101, DOI 10.1016/j.cmet.2017.09.019
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Demirci M, 2020, J DIABETES COMPLICAT, V34, DOI 10.1016/j.jdiacomp.2019.107449
   Fernandes J, 2014, NUTR DIABETES, V4, DOI 10.1038/nutd.2014.23
   Gonai M, 2017, BENEF MICROBES, V8, P705, DOI 10.3920/BM2016.0230
   Gurung M, 2020, EBIOMEDICINE, V51, DOI 10.1016/j.ebiom.2019.11.051
   Han LH, 2019, NUTRIENTS, V11, DOI 10.3390/nu11030670
   Hernandez MAG, 2019, NUTRIENTS, V11, DOI 10.3390/nu11081943
   Just S, 2018, MICROBIOME, V6, DOI 10.1186/s40168-018-0510-8
   Kayano Y, 2009, BIOL PHARM BULL, V32, P1486, DOI 10.1248/bpb.32.1486
   Kothe E, 2018, J BASIC MICROB, V58, P719, DOI 10.1002/jobm.201870028
   Lagkouvardos I, 2019, MICROBIOME, V7, DOI 10.1186/s40168-019-0637-2
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Lee DM, 2018, CARDIOVASC DIABETOL, V17, DOI 10.1186/s12933-018-0708-x
   Lehmann A, 2016, AM J PHYSIOL-GASTR L, V310, pG887, DOI 10.1152/ajpgi.00068.2016
   Mishima E, 2018, AM J PHYSIOL-RENAL, V315, pF824, DOI 10.1152/ajprenal.00314.2017
   Montandon SA, 2017, GENES-BASEL, V8, DOI 10.3390/genes8100250
   Mori K, 2016, BIOPHARM DRUG DISPOS, V37, P491, DOI 10.1002/bdd.2040
   Omori K, 2019, METABOLISM, V98, P27, DOI 10.1016/j.metabol.2019.06.006
   Papakitsou I, 2019, CLIN PHARMACOL-ADV A, V11, P133, DOI 10.2147/CPAA.S172353
   Qin JJ, 2010, NATURE, V464, P59, DOI 10.1038/nature08821
   Schoenborn L, 2001, J CLIN MICROBIOL, V39, P787, DOI 10.1128/JCM.39.2.787-790.2001
   Singer-Englar T, 2019, EXPERT REV GASTROENT, V13, P3, DOI 10.1080/17474124.2019.1543023
   Smith BJ, 2019, BMC MICROBIOL, V19, DOI 10.1186/s12866-019-1494-7
   Tahrani AA, 2013, LANCET DIABETES ENDO, V1, P140, DOI 10.1016/S2213-8587(13)70050-0
   Tanday N, 2020, BIOCHEM PHARMACOL, V177, DOI 10.1016/j.bcp.2020.114009
   van Bommel EJM, 2020, DIABETES METAB, V46, P164, DOI 10.1016/j.diabet.2019.11.005
   van Bommel EJM, 2017, CLIN J AM SOC NEPHRO, V12, P700, DOI 10.2215/CJN.06080616
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Yan HL, 2017, PHYTOMEDICINE, V26, P45, DOI 10.1016/j.phymed.2017.01.007
   Zhang MC, 2019, BMJ OPEN DIAB RES CA, V7, DOI 10.1136/bmjdrc-2019-000717
   Zhang Q, 2018, PEERJ, V6, DOI 10.7717/peerj.4446
   Zhang Q, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0079697
   Zhao LJ, 2019, ENDOCRINE, V66, P526, DOI 10.1007/s12020-019-02103-8
NR 36
TC 25
Z9 27
U1 5
U2 13
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD NOV 17
PY 2020
VL 11
AR 635
DI 10.3389/fendo.2020.00635
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA OZ2DS
UT WOS:000594743800001
PM 33312157
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Hur, KY
   Lee, MS
AF Hur, Kyu Yeon
   Lee, Myung-Shik
TI Gut Microbiota and Metabolic Disorders
SO DIABETES & METABOLISM JOURNAL
LA English
DT Article
DE Gut; Metformin; Microbiota; Obesity
ID DIET-INDUCED OBESITY; HIGH-FAT-DIET; INTESTINAL PERMEABILITY; INSULIN
   SENSITIVITY; MICE; INFLAMMATION; ENDOTOXEMIA; GLUCOSE; INCREASES;
   IMPROVEMENT
AB Gut microbiota plays critical physiological roles in the energy extraction and in the control of local or systemic immunity. Gut microbiota and its disturbance also appear to be involved in the pathogenesis of diverse diseases including metabolic disorders, gastrointestinal diseases, cancer, etc. In the metabolic point of view, gut microbiota can modulate lipid accumulation, lipopolysaccharide content and the production of short-chain fatty acids that affect food intake, inflammatory tone, or insulin signaling. Several strategies have been developed to change gut microbiota such as prebiotics, probiotics, certain antidiabetic drugs or fecal microbiota transplantation, which have diverse effects on body metabolism and on the development of metabolic disorders.
C1 [Hur, Kyu Yeon] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Div Endocrinol & Metab,Dept Internal Med, Seoul, South Korea.
   [Lee, Myung-Shik] Yonsei Univ, Coll Med, Severance Biomed Res Inst, 50-1 Yonsei Ro, Seoul 120752, South Korea.
   [Lee, Myung-Shik] Yonsei Univ, Coll Med, Dept Internal Med, Seoul 120752, South Korea.
C3 Sungkyunkwan University (SKKU); Samsung Medical Center; Yonsei
   University; Yonsei University Health System; Yonsei University; Yonsei
   University Health System
RP Lee, MS (通讯作者)，Yonsei Univ, Coll Med, Severance Biomed Res Inst, 50-1 Yonsei Ro, Seoul 120752, South Korea.
EM mslee0923@yuhs.ac
RI Lee, Myung Shik/C-9606-2011
OI Lee, Myung-Shik/0000-0003-3292-1720
FU Global Research Laboratory Grant from the National Research Foundation
   of Korea [K21004000003-12A0500-00310]; Ulsan National Institute of
   Science and Technology Research Fund [2014M3A9D8034459]; National
   Research Foundation of Korea [2010-00347] Funding Source: Korea
   Institute of Science & Technology Information (KISTI), National Science
   & Technology Information Service (NTIS)
FX This study was supported by a Global Research Laboratory Grant
   (K21004000003-12A0500-00310) from the National Research Foundation of
   Korea and the Ulsan National Institute of Science and Technology
   Research Fund (2014M3A9D8034459).
CR Alvarez-Castro P, 2013, MINI-REV MED CHEM, V13, P541, DOI 10.2174/1389557511313040007
   Amar J, 2011, EMBO MOL MED, V3, P559, DOI 10.1002/emmm.201100159
   Backhed F, 2004, P NATL ACAD SCI USA, V101, P15718, DOI 10.1073/pnas.0407076101
   Backhed F, 2005, SCIENCE, V307, P1915, DOI 10.1126/science.1104816
   Backhed F, 2007, P NATL ACAD SCI USA, V104, P979, DOI 10.1073/pnas.0605374104
   Moreira APB, 2012, BRIT J NUTR, V108, P801, DOI 10.1017/S0007114512001213
   Brun P, 2007, AM J PHYSIOL-GASTR L, V292, pG518, DOI 10.1152/ajpgi.00024.2006
   Cabreiro F, 2013, CELL, V153, P228, DOI 10.1016/j.cell.2013.02.035
   Cani PD, 2007, DIABETOLOGIA, V50, P2374, DOI 10.1007/s00125-007-0791-0
   Cani PD, 2009, GUT, V58, P1091, DOI 10.1136/gut.2008.165886
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   Cani PD, 2009, AM J CLIN NUTR, V90, P1236, DOI 10.3945/ajcn.2009.28095
   Cani PD, 2006, DIABETES, V55, P1484, DOI 10.2337/db05-1360
   Conterno L, 2011, GENES NUTR, V6, P241, DOI 10.1007/s12263-011-0230-1
   de Kort S, 2011, OBES REV, V12, P449, DOI 10.1111/j.1467-789X.2010.00845.x
   De Vadder F, 2014, CELL, V156, P84, DOI 10.1016/j.cell.2013.12.016
   Delaere F, 2013, MOL METAB, V2, P47, DOI 10.1016/j.molmet.2012.11.003
   Delzenne N, 2010, OBES REV, V11, P234, DOI 10.1111/j.1467-789X.2009.00707.x
   Everard A, 2014, ISME J, V8, P2116, DOI 10.1038/ismej.2014.45
   Everard A, 2011, DIABETES, V60, P2775, DOI 10.2337/db11-0227
   Ewaschuk J, 2007, HEPATOLOGY, V46, P841, DOI 10.1002/hep.21750
   Guarner F, 2007, J NUTR, V137, p2568S, DOI 10.1093/jn/137.11.2568S
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kimura I, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms2852
   Lakhan SE, 2011, J TRANSL MED, V9, DOI 10.1186/1479-5876-9-202
   Ley RE, 2005, P NATL ACAD SCI USA, V102, P11070, DOI 10.1073/pnas.0504978102
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Qin JJ, 2010, NATURE, V464, P59, DOI 10.1038/nature08821
   Roberfroid M, 2010, BRIT J NUTR, V104, pS1, DOI 10.1017/S0007114510003363
   Shan MM, 2013, SCIENCE, V342, P447, DOI 10.1126/science.1237910
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Tazoe H, 2008, J PHYSIOL PHARMACOL, V59, P251
   Turnbaugh PJ, 2008, CELL HOST MICROBE, V3, P213, DOI 10.1016/j.chom.2008.02.015
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   van Nood E, 2013, NEW ENGL J MED, V368, P2145, DOI [10.1056/NEJMoa1205037, 10.1056/NEJMc1303919]
   Vrieze A, 2012, GASTROENTEROLOGY, V143, P913, DOI 10.1053/j.gastro.2012.06.031
NR 37
TC 135
Z9 146
U1 5
U2 58
PU KOREAN DIABETES ASSOC
PI SEOUL
PA 1010 RENAISSANCE TOWER BLDG, 14 MANRIJAE-RO, MAPO-GUO, SEOUL, 121-706,
   SOUTH KOREA
SN 2233-6079
EI 2233-6087
J9 DIABETES METAB J
JI Diabetes Metab. J.
PD JUN
PY 2015
VL 39
IS 3
BP 198
EP 203
DI 10.4093/dmj.2015.39.3.198
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DA7RT
UT WOS:000368002500003
PM 26124989
OA Green Submitted, Green Published, gold
DA 2023-06-08
ER

PT J
AU Han, K
   Bose, S
   Wang, JH
   Lim, SK
   Chin, YW
   Kim, YM
   Choi, HS
   Kim, H
AF Han, Kyungsun
   Bose, Shambhunath
   Wang, Jing-Hua
   Lim, Soo-kyoung
   Chin, Young-Won
   Kim, Young-Mi
   Choi, Han-Seok
   Kim, Hojun
TI In vivo therapeutic effect of combination treatment with metformin and
   Scutellaria baicalensis on maintaining bile acid homeostasis
SO PLOS ONE
LA English
DT Article
ID GUT MICROBIOTA; FLAVONOIDS; ROOT; FXR; RECEPTORS
AB The radix of Scutellaria baicalensis (SB) is a herb widely used in traditional Chinese medicine to treat metabolic diseases. Several main components, including baicalin and wogonoside, possess anti-dyslipidemia, anti-obesity and anti-diabetic effects. We hypothesized that co-administration of SB extract and metformin exerts a better effect on obesity-induced insulin resistance and lipid metabolism than treatment with metformin alone. We compared the effect of metformin (100 mg/10 mL/kg/day) alone with co-administration of metformin (100 mg/5 mL/kg/day) and SB extract (200 mg/5 mL/kg/day) on Otsuka Long Evans Tokushima Fatty rats, a useful model of type II diabetes with obesity, and used Long-Evans Tokushima Otsuka rats as a control. Weight, fasting glucose, oral glucose tolerance test, intraperitoneal insulin tolerance test, and serum total cholesterol were measured after 12 weeks of drug administration. We observed a synergetic effect of metformin and SB on lowering cholesterol level by excretion of bile acid through feces. We found that this accompanied activation of FXR, CYP7A1 and LDLR genes and repression of HMGCR in the liver. Although there were no significant changes in BSH-active gut microbiota due to high variability, functional prediction with 16S sequences showed increased primary and secondary bile acid biosynthesis in the combination treatment group. Further study is needed to find the specific strains of bacteria which contribute to FXR-related cholesterol and bile acid regulations.
C1 [Han, Kyungsun; Wang, Jing-Hua; Lim, Soo-kyoung; Kim, Hojun] Dongguk Univ, Korean Med, Dept Rehabil Med, Goyang, Gyeonggi Do, South Korea.
   [Han, Kyungsun] Korea Inst Oriental Med, Clin Res Div, Daejeon, South Korea.
   [Bose, Shambhunath] Appl Surface Technol Inc, Adv Inst Convergence Technol, 11th Floor,Bldg A, Suwon, South Korea.
   [Chin, Young-Won; Kim, Young-Mi] Dongguk Univ, Coll Pharm, Goyang, Gyeonggi Do, South Korea.
   [Choi, Han-Seok] Dongguk Univ, Dept Endocrinol, Goyang, Gyeonggi Do, South Korea.
C3 Dongguk University; Korea Institute of Oriental Medicine (KIOM); Dongguk
   University; Dongguk University
RP Kim, H (通讯作者)，Dongguk Univ, Korean Med, Dept Rehabil Med, Goyang, Gyeonggi Do, South Korea.
EM kimklar@dongguk.ac.kr
RI Han, Kyungsun/AAG-1044-2020; Choi, Han Seok/AAG-1493-2019; Bose,
   Shambhunath/HKW-2568-2023; Kim, Hojun/AAB-8405-2020; Wang,
   Jing-hua/AAO-2350-2020
OI Han, Kyungsun/0000-0002-9710-7845; Wang, Jing-hua/0000-0002-2034-7429;
   Kim, Hojun/0000-0003-1038-0142; Bose, Shambunath/0000-0003-0737-5713;
   Chin, Young-Won/0000-0001-6964-1779
FU Convergence of Conventional Medicine and Traditional Korean Medicine R&D
   program - Ministry of Health and Welfare through the KHIDI (Korea Health
   Industry Development Institute) [HI14C0558]
FX This work was supported by the grant of Convergence of Conventional
   Medicine and Traditional Korean Medicine R&D program funded by the
   Ministry of Health and Welfare through the KHIDI (Korea Health Industry
   Development Institute, HI14C0558). Author Shambhunath Bose receives a
   salary from Applied Surface Technology, Inc. The specific roles of this
   author are articulated in the 'author contributions' section. The
   funders did not play any role in the study design, data collection and
   analysis, decision to publish, or preparation of the manuscript.
CR BROWN MS, 1983, J CLIN INVEST, V72, P743, DOI 10.1172/JCI111044
   Buhaescu I, 2007, CLIN BIOCHEM, V40, P575, DOI 10.1016/j.clinbiochem.2007.03.016
   Caporaso JG, 2010, NAT METHODS, V7, P335, DOI 10.1038/nmeth.f.303
   Chiang JYL, 2009, J LIPID RES, V50, P1955, DOI 10.1194/jlr.R900010-JLR200
   Degirolamo C, 2014, CELL REP, V7, P12, DOI 10.1016/j.celrep.2014.02.032
   Fiorucci S, 2015, TRENDS MOL MED, V21, P702, DOI 10.1016/j.molmed.2015.09.001
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Heo HJ, 2004, J AGR FOOD CHEM, V52, P4128, DOI 10.1021/jf049953x
   Horvath CR, 2005, J CHROMATOGR A, V1062, P199, DOI 10.1016/j.chroma.2004.11.030
   Huang WH, 2006, BIOSCI BIOTECH BIOCH, V70, P2371, DOI 10.1271/bbb.50698
   Huang WH, 2003, CHEM PHARM BULL, V51, P339
   Islam KBMS, 2011, GASTROENTEROLOGY, V141, P1773, DOI 10.1053/j.gastro.2011.07.046
   Istvan ES, 2001, SCIENCE, V292, P1160, DOI 10.1126/science.1059344
   Jung HS, 2012, J ETHNOPHARMACOL, V141, P345, DOI 10.1016/j.jep.2012.02.044
   Kanehisa M, 2000, NUCLEIC ACIDS RES, V28, P27, DOI 10.1093/nar/28.1.27
   Kim EH, 2009, J ETHNOPHARMACOL, V126, P320, DOI 10.1016/j.jep.2009.08.027
   Kovacs G, 2004, CHROMATOGRAPHIA, V60, pS81, DOI 10.1365/s10337-004-0266-0
   Kroliczewska B, 2011, J ANIM PHYSIOL AN N, V95, P114, DOI 10.1111/j.1439-0396.2010.01033.x
   Langille MGI, 2013, NAT BIOTECHNOL, V31, P814, DOI 10.1038/nbt.2676
   Li GJ, 2012, PROCEDIA ENVIRON SCI, V12, P1180, DOI 10.1016/j.proenv.2012.01.405
   Li HB, 2005, J CHROMATOGR A, V1074, P107, DOI 10.1016/j.chroma.2005.03.088
   Lien F, 2014, J CLIN INVEST, V124, P1037, DOI 10.1172/JCI68815
   Mazuy C, 2015, CELL MOL LIFE SCI, V72, P1631, DOI 10.1007/s00018-014-1805-y
   NAGAI T, 1995, ANTIVIR RES, V26, P11, DOI 10.1016/0166-3542(94)00062-D
   Napolitano A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100778
   Popescu IR, 2010, FEBS LETT, V584, P2845, DOI 10.1016/j.febslet.2010.04.068
   Pu P, MOL CELL ENDOCRINOL
   Ridlon JM, 2013, GUT MICROBES, V4, P382, DOI 10.4161/gmic.25723
   Ridlon JM, 2006, J LIPID RES, V47, P241, DOI 10.1194/jlr.R500013-JLR200
   Sayin SI, 2013, CELL METAB, V17, P225, DOI 10.1016/j.cmet.2013.01.003
   Seo MJ, 2014, FOOD CHEM TOXICOL, V67, P57, DOI 10.1016/j.fct.2014.02.009
   Song KH, 2013, PHYTOTHER RES, V27, P244, DOI 10.1002/ptr.4691
   Tremaroli V, 2012, NATURE, V489, P242, DOI 10.1038/nature11552
   U.S. Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research (CDER), 2005, PHARMACOL TOXICOL
   Waisundara VY, 2008, AM J CHINESE MED, V36, P517, DOI 10.1142/S0192415X08005953
   Wilson ID, 2009, CURR PHARM DESIGN, V15, P1519, DOI 10.2174/138161209788168173
   Woudenberg-Vrenken TE, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0071773
   Wulffele MG, 2004, J INTERN MED, V256, P1, DOI 10.1111/j.1365-2796.2004.01328.x
   Ye F, 2002, J ALTERN COMPLEM MED, V8, P567, DOI 10.1089/107555302320825075
   Zhang X, 2015, EURASIP J AUDIO SPEE, DOI 10.1186/s13636-015-0050-0
   Zheng Q, 2009, BMC GENOMICS, V10, DOI 10.1186/1471-2164-10-87
   윤혜진, 2010, [Journal of the Korean Society of Food Science and Nutrition, 한국식품영양과학회지], V39, P219
NR 42
TC 35
Z9 37
U1 0
U2 26
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 6
PY 2017
VL 12
IS 9
AR e0182467
DI 10.1371/journal.pone.0182467
PG 17
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA FG0EG
UT WOS:000409391200014
PM 28877164
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Ding, QY
   Tian, JX
   Li, M
   Lian, FM
   Zhao, LH
   Wei, XX
   Han, L
   Zheng, YJ
   Gao, ZZ
   Yang, HY
   Fang, XY
   Tong, XL
AF Ding, Qi-You
   Tian, Jia-Xing
   Li, Min
   Lian, Feng-Mei
   Zhao, Lin-Hua
   Wei, Xiu-Xiu
   Han, Lin
   Zheng, Yu-Jiao
   Gao, Ze-Zheng
   Yang, Hao-Yu
   Fang, Xin-Yi
   Tong, Xiao-lin
TI Interactions Between Therapeutics for Metabolic Disease, Cardiovascular
   Risk Factors, and Gut Microbiota
SO FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
LA English
DT Review
DE metabolic therapy; gut microbiota; cardiovascular diseases; metformin;
   microbiota-targeted therapies
ID CORONARY-HEART-DISEASE; CHAIN FATTY-ACIDS; IMPAIRED GLUCOSE-TOLERANCE;
   ALL-CAUSE MORTALITY; AKKERMANSIA-MUCINIPHILA; INTESTINAL MICROBIOTA;
   ACARBOSE TREATMENT; RECEPTOR AGONISTS; DIABETES-MELLITUS; OXIDATIVE
   STRESS
AB With improved standards of living, the incidence of multiple metabolic disorders has increased year by year, especially major risk factors for cardiovascular disease such as hyperglycemia and hyperlipidemia, continues to increase. Emerging epidemiological data and clinical trials have shown the additional protective effects of some metabolic therapy drugs against cardiovascular diseases. A series of studies have found that these drugs may work by modulating the composition of gut microbiota. In this review, we provide a brief overview of the contribution of the gut microbiota to both metabolic disorders and cardiovascular diseases, as well as the response of gut microbiota to metabolic therapy drugs with cardiovascular benefits. In this manner, we link the recent advances in microbiome studies on metabolic treatment drugs with their cardiovascular protective effects, suggesting that intestinal microorganisms may play a potential role in reducing cardiovascular risk factors. We also discuss the potential of microorganism-targeted therapeutics as treatment strategies for preventing and/or treating cardiovascular disease and highlight the need to establish causal links between therapeutics for metabolic diseases, gut microbiota modulation, and cardiovascular protection.
C1 [Ding, Qi-You; Tian, Jia-Xing; Li, Min; Lian, Feng-Mei; Zhao, Lin-Hua; Wei, Xiu-Xiu; Han, Lin; Zheng, Yu-Jiao; Gao, Ze-Zheng; Yang, Hao-Yu; Fang, Xin-Yi; Tong, Xiao-lin] China Acad Chinese Med Sci, Guanganmen Hosp, Dept Endocrinol, Beijing, Peoples R China.
   [Ding, Qi-You; Wei, Xiu-Xiu; Zheng, Yu-Jiao; Gao, Ze-Zheng; Yang, Hao-Yu; Fang, Xin-Yi] Beijing Univ Tradit Chinese Med, Grad Coll, Beijing, Peoples R China.
C3 China Academy of Chinese Medical Sciences; Guang'anmen Hospital, CACMS;
   Beijing University of Chinese Medicine
RP Tian, JX; Tong, XL (通讯作者)，China Acad Chinese Med Sci, Guanganmen Hosp, Dept Endocrinol, Beijing, Peoples R China.
EM tina_yai@126.com; tongxiaolin@vip.163.com
FU Young Elite Scientists Sponsorship Program by CAST [YESS20170034,
   2018QNRC2-C10]; National Natural Science Foundation of China [81904187,
   81274000, 81803923]; Special Scientific Research for Traditional Chinese
   Medicine of China [201507001-11]; Capital Health Development Research
   Project [CD2020-4-4155]; Outstanding Young Scientific and Technological
   Talents Program [ZZ13-YQ-026]
FX This work was partially supported by the Young Elite Scientists
   Sponsorship Program by CAST (YESS20170034 and 2018QNRC2-C10), the
   National Natural Science Foundation of China (Nos. 81904187, 81274000,
   and 81803923), Special Scientific Research for Traditional Chinese
   Medicine of China (201507001-11), Capital Health Development Research
   Project (CD2020-4-4155), and the Outstanding Young Scientific and
   Technological Talents Program (ZZ13-YQ-026).
CR Bailey CJ, 2008, DIABETOLOGIA, V51, P1552, DOI 10.1007/s00125-008-1053-5
   Barr ELM, 2007, CIRCULATION, V116, P151, DOI 10.1161/CIRCULATIONAHA.106.685628
   Bauer PV, 2018, CELL METAB, V27, P101, DOI 10.1016/j.cmet.2017.09.019
   Becker N, 2011, GUT MICROBES, V2, P25, DOI 10.4161/gmic.2.1.14651
   Bennett BJ, 2013, CELL METAB, V17, P49, DOI 10.1016/j.cmet.2012.12.011
   BONORA E, 1984, CURR MED RES OPIN, V9, P47, DOI 10.1185/03007998409109558
   Borch-Johnsen K, 2001, ARCH INTERN MED, V161, P397, DOI 10.1001/archinte.161.3.397
   Boulange CL, 2016, GENOME MED, V8, DOI 10.1186/s13073-016-0303-2
   Boyle JG, 2018, CLIN SCI, V132, P1699, DOI 10.1042/CS20171299
   Bronden A, 2017, J CLIN ENDOCR METAB, V102, P4153, DOI 10.1210/jc.2017-01091
   Brown JM, 2018, NAT REV MICROBIOL, V16, P171, DOI 10.1038/nrmicro.2017.149
   Brown JM, 2017, J BIOL CHEM, V292, P8560, DOI 10.1074/jbc.R116.765388
   Brunkwall L, 2017, DIABETOLOGIA, V60, P943, DOI 10.1007/s00125-017-4278-3
   Buse JB, 2016, DIABETES CARE, V39, P198, DOI 10.2337/dc15-0488
   Canfora EE, 2015, NAT REV ENDOCRINOL, V11, P577, DOI 10.1038/nrendo.2015.128
   Cani PD, 2018, GUT, V67, P1716, DOI 10.1136/gutjnl-2018-316723
   CASPARY WF, 1975, DIABETOLOGIA, V11, P113, DOI 10.1007/BF00429833
   Chambers ES, 2015, GUT, V64, P1744, DOI 10.1136/gutjnl-2014-307913
   Chauveau P, 2013, NEPHROL THER, V9, P202, DOI 10.1016/j.nephro.2013.03.011
   Chelakkot C, 2018, EXP MOL MED, V50, DOI 10.1038/emm.2017.282
   Chen JM, 2014, J DIABETES RES, V2014, DOI 10.1155/2014/812628
   Chiasson JL, 2003, JAMA-J AM MED ASSOC, V290, P486, DOI 10.1001/jama.290.4.486
   Clemente JC, 2012, CELL, V148, P1258, DOI 10.1016/j.cell.2012.01.035
   Costello EK, 2012, SCIENCE, V336, P1255, DOI 10.1126/science.1224203
   Croyal M, 2020, J CLIN ENDOCR METAB, V105, P2371, DOI 10.1210/clinem/dgaa188
   Curtiss LK, 2009, J LIPID RES, V50, pS340, DOI 10.1194/jlr.R800056-JLR200
   Dao MC, 2016, GUT, V65, P426, DOI 10.1136/gutjnl-2014-308778
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   De Vadder F, 2016, CELL METAB, V24, P151, DOI 10.1016/j.cmet.2016.06.013
   DEFRONZO RA, 1991, DIABETES CARE, V14, P173, DOI 10.2337/diacare.14.3.173
   den Besten G, 2015, DIABETES, V64, P2398, DOI 10.2337/db14-1213
   Duca FA, 2015, NAT MED, V21, P506, DOI 10.1038/nm.3787
   Eckburg PB, 2005, SCIENCE, V308, P1635, DOI 10.1126/science.1110591
   Eliasson B, 2011, DIABETES CARE, V34, P2095, DOI 10.2337/dc11-0209
   Emoto T, 2016, J ATHEROSCLER THROMB, V23, P908, DOI 10.5551/jat.32672
   Esposito K, 2002, CIRCULATION, V106, P2067, DOI 10.1161/01.CIR.0000034509.14906.AE
   Estaki M, 2016, MICROBIOME, V4, DOI 10.1186/s40168-016-0189-7
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Foretz M, 2019, NAT REV ENDOCRINOL, V15, P569, DOI 10.1038/s41574-019-0242-2
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Fujisaka S, 2018, CELL REP, V22, P3072, DOI 10.1016/j.celrep.2018.02.060
   Gao ZG, 2009, DIABETES, V58, P1509, DOI 10.2337/db08-1637
   Geng DF, 2011, ATHEROSCLEROSIS, V218, P214, DOI 10.1016/j.atherosclerosis.2011.05.004
   Goncalves P, 2018, INFLAMM BOWEL DIS, V24, P558, DOI 10.1093/ibd/izx029
   Green JB, 2015, NEW ENGL J MED, V373, P232, DOI 10.1056/NEJMoa1501352
   Grice EA, 2012, ANNU REV GENOM HUM G, V13, P151, DOI 10.1146/annurev-genom-090711-163814
   Grundy SM, 2004, CIRCULATION, V110, P227, DOI 10.1161/01.CIR.0000133317.49796.0E
   Gu YY, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-01682-2
   Han YC, 2019, CARDIOVASC DIABETOL, V18, DOI 10.1186/s12933-019-0900-7
   Hanefeld M, 2004, EUR HEART J, V25, P10, DOI 10.1016/S0195-668X(03)00468-8
   Hanefeld M, 2007, CARDIOVASC DIABETOL, V6, DOI 10.1186/1475-2840-6-20
   He XY, 2017, J PROTEOME RES, V16, P1900, DOI 10.1021/acs.jproteome.6b00984
   Hillman ET, 2017, MICROBES ENVIRON, V32, P300, DOI 10.1264/jsme2.ME17017
   Holman RR, 2008, NEW ENGL J MED, V359, P1577, DOI 10.1056/NEJMoa0806470
   Holman RR, 2017, LANCET DIABETES ENDO, V5, P877, DOI 10.1016/S2213-8587(17)30309-1
   Holst JJ, 1998, DIABETES, V47, P1663, DOI 10.2337/diabetes.47.11.1663
   Hong J, 2013, DIABETES CARE, V36, P1304, DOI 10.2337/dc12-0719
   Ishibashi T, 2019, CURR PHARM DESIGN, V25, P946, DOI 10.2174/1381612825666190506123038
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Jadhav S, 2006, J AM COLL CARDIOL, V48, P956, DOI 10.1016/j.jacc.2006.04.088
   Jefferis BJMH, 2011, ATHEROSCLEROSIS, V217, P227, DOI 10.1016/j.atherosclerosis.2011.03.015
   Jiao N, 2018, PHYSIOL GENOMICS, V50, P244, DOI 10.1152/physiolgenomics.00114.2017
   Jie ZY, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-00900-1
   Joyce SA, 2017, DIGEST DIS, V35, P169, DOI 10.1159/000450907
   Kaddurah-Daouk R, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0025482
   Karbownik M, 2006, CELL BIOCHEM FUNCT, V24, P483, DOI 10.1002/cbf.1321
   Karlson B, 2016, EUR HEART J-CARD PHA, V2, P212, DOI 10.1093/ehjcvp/pvw006
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kawano H, 1999, J AM COLL CARDIOL, V34, P146, DOI 10.1016/S0735-1097(99)00168-0
   Khan TJ, 2018, OMICS, V22, P154, DOI 10.1089/omi.2017.0130
   Khan TJ, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-017-19013-2
   Khat DZ, 2018, CURR DIABETES REP, V18, DOI 10.1007/s11892-018-1011-7
   Kikuchi K, 2018, BIOCHEM BIOPH RES CO, V501, P1041, DOI 10.1016/j.bbrc.2018.05.105
   Kim J, 2019, FRONT MICROBIOL, V10, DOI 10.3389/fmicb.2019.01947
   Kimura I, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms2852
   Koeth RA, 2014, CELL METAB, V20, P799, DOI 10.1016/j.cmet.2014.10.006
   Koh A, 2016, CELL, V165, P1332, DOI 10.1016/j.cell.2016.05.041
   Kooy A, 2009, ARCH INTERN MED, V169, P616, DOI 10.1001/archinternmed.2009.20
   Kulkarni S, 2018, INDIAN J MED RES, V148, P705, DOI 10.4103/ijmr.IJMR_1201_17
   Lahnwong S, 2018, CARDIOVASC DIABETOL, V17, DOI 10.1186/s12933-018-0745-5
   Lam Vy, 2016, PLoS One, V11, pe0160840, DOI 10.1371/journal.pone.0160840
   Le Vee M, 2009, DRUG METAB DISPOS, V37, P685, DOI 10.1124/dmd.108.023630
   Lee DM, 2018, CARDIOVASC DIABETOL, V17, DOI 10.1186/s12933-018-0708-x
   Lee H, 2019, IMMUNE NETW, V19, DOI 10.4110/in.2019.19.e28
   Li J, 2016, CIRCULATION, V133, P2434, DOI 10.1161/CIRCULATIONAHA.115.019645
   Liao XY, 2019, EBIOMEDICINE, V44, P665, DOI 10.1016/j.ebiom.2019.03.057
   Lin HP, 2012, PLOS ONE, V7, DOI [10.1371/journal.pone.0031286, 10.1371/journal.pone.0035240]
   [刘海霞 Liu Haixia], 2011, [中华内分泌代谢杂志, Chinese Journal of Endocrinology and Metabolism], V27, P928
   Liu YH, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.00530
   Loh M, 2019, MOL METAB, V27, pS33, DOI 10.1016/j.molmet.2019.06.011
   Madamanchi NR, 2005, J THROMB HAEMOST, V3, P254, DOI 10.1111/j.1538-7836.2004.01085.x
   Madsen MSA, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-52103-x
   Marso SP, 2016, NEW ENGL J MED, V375, P311, DOI 10.1056/NEJMoa1603827
   Matsubara T, 2013, MOL CELL ENDOCRINOL, V368, P17, DOI 10.1016/j.mce.2012.05.004
   Mazzone T, 2008, LANCET, V371, P1800, DOI 10.1016/S0140-6736(08)60768-0
   McAdam-Marx C, 2014, DIABETES RES CLIN PR, V103, P402, DOI 10.1016/j.diabres.2013.12.038
   Medzhitov R, 2007, NATURE, V449, P819, DOI 10.1038/nature06246
   Meier JJ, 2012, NAT REV ENDOCRINOL, V8, P728, DOI 10.1038/nrendo.2012.140
   Mohan M, 2019, EUR HEART J, V40, P3409, DOI 10.1093/eurheartj/ehz203
   Monami M, 2017, INT J CARDIOL, V240, P414, DOI 10.1016/j.ijcard.2017.03.163
   Montandon SA, 2017, GENES-BASEL, V8, DOI 10.3390/genes8100250
   Mooradian AD, 2009, NAT CLIN PRACT ENDOC, V5, P150, DOI 10.1038/ncpendmet1066
   Morgan CL, 2014, DIABETES OBES METAB, V16, P957, DOI 10.1111/dom.12302
   Mulvihill EE, 2014, ENDOCR REV, V35, P992, DOI 10.1210/er.2014-1035
   Napolitano A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100778
   Neal B, 2017, NEW ENGL J MED, V377, P644, DOI 10.1056/NEJMoa1611925
   Nemet I, 2020, CELL, V180, P862, DOI 10.1016/j.cell.2020.02.016
   Neves AL, 2013, J MOL ENDOCRINOL, V51, pR51, DOI 10.1530/JME-13-0079
   Nicholson JK, 2012, SCIENCE, V336, P1262, DOI 10.1126/science.1223813
   Ning F, 2010, DIABETES CARE, V33, P2211, DOI 10.2337/dc09-2328
   Node K, 2009, CARDIOVASC DIABETOL, V8, DOI 10.1186/1475-2840-8-23
   Olivares M, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.01900
   Pahwa R, 2017, J DIABETES RES, V2017, DOI 10.1155/2017/6519785
   Palm NW, 2015, CLIN IMMUNOL, V159, P122, DOI 10.1016/j.clim.2015.05.014
   Pernicova I, 2014, NAT REV ENDOCRINOL, V10, P143, DOI 10.1038/nrendo.2013.256
   Philpott DJ, 2014, NAT REV IMMUNOL, V14, P9, DOI 10.1038/nri3565
   Plovier H, 2017, NAT MED, V23, P107, DOI 10.1038/nm.4236
   Pols TWH, 2011, CELL METAB, V14, P747, DOI 10.1016/j.cmet.2011.11.006
   Preiss D, 2014, LANCET DIABETES ENDO, V2, P116, DOI 10.1016/S2213-8587(13)70152-9
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Qin JJ, 2010, NATURE, V464, P59, DOI 10.1038/nature08821
   Rena G, 2018, CIRCULATION, V137, P422, DOI 10.1161/CIRCULATIONAHA.117.031735
   Ripatti S, 2010, LANCET, V376, P1393, DOI 10.1016/S0140-6736(10)61267-6
   Roager HM, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-018-05470-4
   Samuel BS, 2008, P NATL ACAD SCI USA, V105, P16767, DOI 10.1073/pnas.0808567105
   Scheen AJ, 2018, CIRC RES, V122, P1439, DOI 10.1161/CIRCRESAHA.117.311588
   Schramm C, 2018, NEW ENGL J MED, V379, P888, DOI 10.1056/NEJMcibr1807106
   Scirica BM, 2013, NEW ENGL J MED, V369, P1317, DOI 10.1056/NEJMoa1307684
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Sonnenburg JL, 2016, NATURE, V535, P56, DOI 10.1038/nature18846
   Stancu C, 2001, J CELL MOL MED, V5, P378, DOI 10.1111/j.1582-4934.2001.tb00172.x
   Standl E, 2014, CARDIOVASC DIABETOL, V13, DOI 10.1186/1475-2840-13-81
   Staudinger JL, 2001, P NATL ACAD SCI USA, V98, P3369, DOI 10.1073/pnas.051551698
   Stepensky D, 2002, DRUG METAB DISPOS, V30, P861, DOI 10.1124/dmd.30.8.861
   Stone NJ, 2014, CIRCULATION, V129, pS1, DOI 10.1161/01.cir.0000437738.63853.7a
   Su BL, 2015, J DIABETES, V7, P729, DOI 10.1111/1753-0407.12232
   Sui YP, 2011, J LIPID RES, V52, P1652, DOI 10.1194/jlr.M017376
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Suzuki Y, 2009, FEBS LETT, V583, P2157, DOI 10.1016/j.febslet.2009.05.052
   Tang WHW, 2019, J AM COLL CARDIOL, V73, P2089, DOI 10.1016/j.jacc.2019.03.024
   Tang WHW, 2017, CIRC RES, V120, P1183, DOI 10.1161/CIRCRESAHA.117.309715
   Tang WHW, 2013, NEW ENGL J MED, V368, P1575, DOI 10.1056/NEJMoa1109400
   Topping DL, 2001, PHYSIOL REV, V81, P1031, DOI 10.1152/physrev.2001.81.3.1031
   Touyz RM, 2004, HYPERTENSION, V44, P248, DOI 10.1161/01.HYP.0000138070.47616.9d
   Turner RC, 1998, LANCET, V352, P854, DOI 10.1016/s0140-6736(98)07037-8
   van Stee MF, 2018, CARDIOVASC DIABETOL, V17, DOI 10.1186/s12933-018-0738-4
   Veiga P, 2005, FEMS MICROBIOL LETT, V242, P81, DOI 10.1016/j.femsle.2004.10.042
   Vilsboll T, 2012, BMJ-BRIT MED J, V344, DOI 10.1136/bmj.d7771
   Viollet B, 2012, CLIN SCI, V122, P253, DOI 10.1042/CS20110386
   Wahlstrom A, 2016, CELL METAB, V24, P41, DOI 10.1016/j.cmet.2016.05.005
   Wang LJ, 2018, LIPIDS HEALTH DIS, V17, DOI 10.1186/s12944-018-0801-x
   Wang L, 2016, SCI REP-UK, V6, DOI [10.1038/srep38380, 10.1038/srep33251, 10.1038/srep20004]
   Wang ZN, 2015, CELL, V163, P1585, DOI 10.1016/j.cell.2015.11.055
   Wang ZN, 2011, NATURE, V472, P57, DOI 10.1038/nature09922
   Wang Zhang, 2018, Endocrinol Diabetes Metab, V1, pe00009, DOI 10.1002/edm2.9
   Wen L, 2017, J NUTR, V147, p1468S, DOI 10.3945/jn.116.240754
   Weng JP, 2015, DIABETES-METAB RES, V31, P155, DOI 10.1002/dmrr.2576
   Whalen K, 2015, CLIN THER, V37, P1150, DOI 10.1016/j.clinthera.2015.03.004
   White WB, 2013, NEW ENGL J MED, V369, P1327, DOI 10.1056/NEJMoa1305889
   Whiting DR, 2011, DIABETES RES CLIN PR, V94, P311, DOI 10.1016/j.diabres.2011.10.029
   Winer DA, 2016, CELL METAB, V23, P413, DOI 10.1016/j.cmet.2016.01.003
   Wiviott SD, 2019, NEW ENGL J MED, V380, P347, DOI 10.1056/NEJMoa1812389
   Wlodarska M, 2017, CELL HOST MICROBE, V22, P25, DOI 10.1016/j.chom.2017.06.007
   Wolf G, 2006, NUTR REV, V64, P47, DOI 10.1301/nr.2006.jan.47-50
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Yan XF, 2016, J DIABETES RES, V2016, DOI 10.1155/2016/2093171
   Zhang Q, 2018, EXP BIOL MED, V243, P34, DOI 10.1177/1535370217743765
   Zhang Q, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0184735
   Zhang YQ, 2006, ARTERIOSCL THROM VAS, V26, P2316, DOI 10.1161/01.ATV.0000235697.35431.05
   Zhao L, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00233
   Zhu WF, 2016, CELL, V165, P111, DOI 10.1016/j.cell.2016.02.011
   Zilov AV, 2019, DIABETES-METAB RES, V35, DOI 10.1002/dmrr.3173
   Zinman B, 2016, NEW ENGL J MED, V374, P1094, DOI 10.1056/NEJMc1600827
NR 173
TC 5
Z9 6
U1 1
U2 14
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2235-2988
J9 FRONT CELL INFECT MI
JI Front. Cell. Infect. Microbiol.
PD OCT 23
PY 2020
VL 10
AR 530160
DI 10.3389/fcimb.2020.530160
PG 14
WC Immunology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Microbiology
GA OM3VN
UT WOS:000585954400001
PM 33194785
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Pircalabioru, GG
   Chifiriuc, MC
   Picu, A
   Petcu, LM
   Trandafir, M
   Savu, O
AF Gradisteanu Pircalabioru, Gratiela
   Chifiriuc, Mariana-Carmen
   Picu, Ariana
   Petcu, Laura Madalina
   Trandafir, Maria
   Savu, Octavian
TI Snapshot into the Type-2-Diabetes-Associated Microbiome of a Romanian
   Cohort
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE microbiota; microbiome; diabetes; metabolites; hypertension; metabolic
   disease
ID CHAIN FATTY-ACIDS; GLUCAGON-LIKE PEPTIDE-1; GUT MICROBIOTA; INTESTINAL
   MICROBIOTA; ASSOCIATION; METAGENOME; DISEASE; WEIGHT; IMPACT
AB The prevalence of type 2 diabetes mellitus (T2D) is alarmingly increasing worldwide, urgently calling for a better understanding of the underlying mechanisms in order to step up prevention and improve therapeutic approaches. It is becoming evident that the gut microbiota seem to have an endless capacity to impact T2D. In this study, we profile the gut microbiome patterns in T2D patients from Romania, by using quantitative Real-Time PCR and next generation sequencing. We enrolled a total of 150 individuals (105 T2D patients, 50 of them without metformin treatment and 45 healthy volunteers). The levels of potentially beneficial butyrate-producing bacteria were significantly reduced, while potentially pathogenic microorganisms such as Enterobacteriaceae and Fusobacterium were enriched in T2D patients. We evaluated the correlation between clinical parameters and gut microbiota and identified the genera Bacteroides, Alistipes, Dialister, Bilophila and Sutterella as possible detrimental factors in T2D. Our findings suggest that the gut microbiota may be a potential target in novel approaches to halt the development of T2D-associated complications.
C1 [Gradisteanu Pircalabioru, Gratiela; Chifiriuc, Mariana-Carmen] Univ Bucharest ICUB, Res Inst, Bucharest 050095, Romania.
   [Gradisteanu Pircalabioru, Gratiela; Chifiriuc, Mariana-Carmen] Acad Romanian Scientists, Bucharest 050045, Romania.
   [Chifiriuc, Mariana-Carmen] Romanian Acad, Bucharest 010071, Romania.
   [Chifiriuc, Mariana-Carmen] Univ Bucharest, Fac Biol, Bucharest 050095, Romania.
   [Picu, Ariana; Petcu, Laura Madalina; Savu, Octavian] NC Paulescu Natl Inst Diabet Nutr & Metab Dis, Bucharest 020042, Romania.
   [Trandafir, Maria; Savu, Octavian] Carol Davila Univ Med & Pharm, Dept Doctoral Sch, 5th Dist, Bucharest 050474, Romania.
C3 Academy of Romanian Scientists (AOSR); Romanian Academy of Sciences;
   University of Bucharest; Carol Davila University of Medicine & Pharmacy
RP Pircalabioru, GG (通讯作者)，Univ Bucharest ICUB, Res Inst, Bucharest 050095, Romania.; Pircalabioru, GG (通讯作者)，Acad Romanian Scientists, Bucharest 050045, Romania.
EM gratiela.gradisteanu@icub.unibuc.ro; octavian.savu@umfcd.ro
RI Chifiriuc, Mariana Carmen/AFP-0825-2022; Savu, Octavian/HJY-6206-2023;
   Gradisteanu, Gratiela/GYJ-6972-2022
OI Chifiriuc, Mariana Carmen/0000-0001-6098-1857; Savu,
   Octavian/0000-0002-5674-3810; 
CR Allin KH, 2018, DIABETOLOGIA, V61, P810, DOI 10.1007/s00125-018-4550-1
   Alvarez-Silva C, 2021, GENOME MED, V13, DOI 10.1186/s13073-021-00856-4
   Amato A, 2010, NEUROGASTROENT MOTIL, V22, P664, DOI 10.1111/j.1365-2982.2010.01476.x
   Anhe FF, 2019, NAT MED, V25, P1031, DOI 10.1038/s41591-019-0516-1
   Baldelli V, 2021, MICROORGANISMS, V9, DOI 10.3390/microorganisms9040697
   Balvers M, 2021, NUTRIENTS, V13, DOI 10.3390/nu13093289
   Canfora EE, 2015, NAT REV ENDOCRINOL, V11, P577, DOI 10.1038/nrendo.2015.128
   Caporaso JG, 2010, NAT METHODS, V7, P335, DOI 10.1038/nmeth.f.303
   Chen WH, 2021, DIABET METAB SYND OB, V14, P4283, DOI 10.2147/DMSO.S320169
   Connors J, 2019, NUTRIENTS, V11, DOI 10.3390/nu11010025
   Cunningham AL, 2021, GUT PATHOG, V13, DOI 10.1186/s13099-021-00446-0
   Dao MC, 2016, GUT, V65, P426, DOI 10.1136/gutjnl-2014-308778
   Elwing JE, 2006, AM J GASTROENTEROL, V101, P1866, DOI 10.1111/j.1572-0241.2006.00651.x
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Fernandes J, 2014, NUTR DIABETES, V4, DOI 10.1038/nutd.2014.23
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Furet JP, 2010, DIABETES, V59, P3049, DOI 10.2337/db10-0253
   Ganesan K, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19123720
   Hamer HM, 2008, ALIMENT PHARM THER, V27, P104, DOI 10.1111/j.1365-2036.2007.03562.x
   International Diabetes Federation, 2019, IDF DIABETES ATLAS, V9th, DOI DOI 10.1520/D7905_D7905M-14
   Kaakoush NO, 2020, TRENDS MICROBIOL, V28, P519, DOI 10.1016/j.tim.2020.02.018
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kelly CJ, 2015, CELL HOST MICROBE, V17, P662, DOI 10.1016/j.chom.2015.03.005
   Lambeth Stacey M, 2015, J Diabetes Obes, V2, P1
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Li Q, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-62224-3
   Loftus M, 2021, BMC MICROBIOL, V21, DOI 10.1186/s12866-021-02153-x
   Maioli TU, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.740636
   Mandoe MJ, 2015, AM J CLIN NUTR, V102, P548, DOI 10.3945/ajcn.115.106799
   Mota M, 2016, J DIABETES, V8, P336, DOI 10.1111/1753-0407.12297
   Naito Y, 2018, J CLIN BIOCHEM NUTR, V63, P33, DOI 10.3164/jcbn.18-57
   Natividad JM, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-018-05249-7
   Navab-Moghadam F, 2017, MICROB PATHOGENESIS, V110, P630, DOI 10.1016/j.micpath.2017.07.034
   Noureldein M, 2022, CELL MOL LIFE SCI, V79, DOI 10.1007/s00018-022-04485-x
   Parker BJ, 2020, FRONT IMMUNOL, V11, DOI 10.3389/fimmu.2020.00906
   Pedersen HK, 2016, NATURE, V535, P376, DOI 10.1038/nature18646
   Pircalabioru G, 2016, CELL HOST MICROBE, V19, P651, DOI 10.1016/j.chom.2016.04.007
   Pircalabioru GG, 2022, METABOLITES, V12, DOI 10.3390/metabo12030218
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Russo GT, 2016, DIABETES CARE, V39, P2278, DOI 10.2337/dc16-1246
   Salamon D, 2018, POL ARCH INTERN MED, V128, P336, DOI 10.20452/pamw.4246
   Salminen S, 1998, BRIT J NUTR, V80, pS147, DOI 10.1079/BJN19980108
   Sanna S, 2019, NAT GENET, V51, P600, DOI 10.1038/s41588-019-0350-x
   Sedighi M, 2017, MICROB PATHOGENESIS, V111, P362, DOI 10.1016/j.micpath.2017.08.038
   Shahi SK, 2022, FRONT IMMUNOL, V13, DOI 10.3389/fimmu.2022.966417
   Sun H, 2013, INT J ENDOCRINOL, V2013, DOI 10.1155/2013/592576
   Tazoe H, 2008, J PHYSIOL PHARMACOL, V59, P251
   Tolhurst G, 2012, DIABETES, V61, P364, DOI 10.2337/db11-1019
   United Nations General Assembly, 2012, POL DECL HIGH LEV M
   Wang L, 2022, FRONT IMMUNOL, V13, DOI 10.3389/fimmu.2022.952398
   World Health Organisation, 2016, GLOBAL REPORT DIABET
   Zhao LJ, 2019, ENDOCRINE, V66, P526, DOI 10.1007/s12020-019-02103-8
   Zhou ZW, 2018, FRONT ONCOL, V8, DOI 10.3389/fonc.2018.00371
NR 53
TC 1
Z9 1
U1 5
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD DEC
PY 2022
VL 23
IS 23
AR 15023
DI 10.3390/ijms232315023
PG 13
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 6X0WA
UT WOS:000896142800001
PM 36499348
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Xiao, Y
   Li, KL
   Bian, J
   Liu, H
   Zhai, XT
   El-Omar, E
   Han, L
   Gong, L
   Wang, M
AF Xiao, Yao
   Li, Kailin
   Bian, Ji
   Liu, Hang
   Zhai, Xiaotong
   El-Omar, Emad
   Han, Lin
   Gong, Lan
   Wang, Min
TI Urolithin A Attenuates Diabetes-Associated Cognitive Impairment by
   Ameliorating Intestinal Barrier Dysfunction via N-glycan Biosynthesis
   Pathway
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Article
DE intestinal barrier; microbiome; N-glycan metabolism; systemic
   inflammation; type 2 diabetes; urolithin A
ID GUT MICROBIOTA; DIETARY POLYPHENOLS; IMMUNE-SYSTEM; ELLAGIC ACID;
   METFORMIN; OBESITY; INFLAMMATION; METABOLITES; RISK; NEUROINFLAMMATION
AB Scope This study aims to investigate the effect of Urolithin A (UA) on diabetes-associated cognitive impairment in type 2 diabetes mellitus (T2DM) mouse model induced by high-fat diet (HFD) and streptozotocin (STZ). Methods and Results The UA-treated T2DM mice display an attenuated cognitive impairment as well as reduced levels of metabolic endotoxemia and proinflammatory cytokines in serum. A systemic restraint of gut/brain inflammation in UA-treated T2DM mice is also observed as the downregulation of TLR4 and Myd88 in colon along with the inhibition of GFAP, Iba-1, NLRP3, and inflammation-related genes in brain. Moreover, UA ameliorates gut barrier dysfunction by upregulating tight-junction proteins levels. Furthermore, UA restores the hyperglycemia-mediated downregulation of genes involved in N-glycan biosynthesis both in vivo and in vitro, which plays a crucial role in barrier integrity. Although UA shares similar beneficial effects on diabetes with metformin, unlike metformin, the effect of UA is independent of gut microbiome and short chain fatty acids. Taken together, these data suggest that feeding UA can attenuate diabetes-associated cognitive impairment by ameliorating systemic inflammation and intestinal barrier dysfunction via N-glycan biosynthesis pathway. The study implies UA as a potential novel pharmaceutic target for diabetes therapy via manipulating gut-brain axis and N-glycan metabolism.
C1 [Xiao, Yao; Li, Kailin; Zhai, Xiaotong; Han, Lin; Wang, Min] Northwest A&F Univ, Coll Food Sci & Engn, Yangling 712100, Shaanxi, Peoples R China.
   [Bian, Ji] Univ Sydney, Royal North Shore Hosp, Sydney Med Sch, Kolling Inst, St Leonards, NSW 2065, Australia.
   [Liu, Hang] Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, Shanghai Ctr Syst Biomed, Shanghai 200240, Peoples R China.
   [Zhai, Xiaotong] Acad Natl Food & Strateg Reserves Adm, 11 Baiwanzhuang St, Beijing 100037, Peoples R China.
   [El-Omar, Emad; Gong, Lan] Univ New South Wales, St George & Sutherland Clin Sch, Microbiome Res Ctr, Sydney, NSW, Australia.
C3 Northwest A&F University - China; Royal North Shore Hospital; University
   of Sydney; Kolling Institute of Medical Research; Shanghai Jiao Tong
   University; University of New South Wales Sydney
RP Han, L; Wang, M (通讯作者)，Northwest A&F Univ, Coll Food Sci & Engn, Yangling 712100, Shaanxi, Peoples R China.; Gong, L (通讯作者)，Univ New South Wales, St George & Sutherland Clin Sch, Microbiome Res Ctr, Sydney, NSW, Australia.
EM hanlin730@163.com; l.gong@unsw.edu.au; wangmin20050606@163.com
RI Li, Kai/HCI-8860-2022; Gong, Lan/O-7886-2019
OI Gong, Lan/0000-0003-3136-1565; Li, Kailin/0000-0003-2588-8766
FU China Agriculture Research System [CARS-08-E2-01]; Natural Science
   Foundation of China [32001701]
FX The authors would like to acknowledge the financial support provided by
   China Agriculture Research System (CARS-08-E2-01), and Natural Science
   Foundation of China (32001701).
CR Abdul-Ghani MA, 2009, DIABETES CARE, V32, pS194, DOI 10.2337/dc09-S309
   Ahsan A, 2019, CNS NEUROSCI THER, V25, P976, DOI 10.1111/cns.13136
   Andreux PA, 2019, NAT METAB, V1, P595, DOI 10.1038/s42255-019-0073-4
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Chen MT, 2020, CLIN NUTR, V39, P1264, DOI 10.1016/j.clnu.2019.05.020
   Chen P, 2019, NEUROTHERAPEUTICS, V16, P1269, DOI 10.1007/s13311-019-00753-0
   Chen YX, 2021, ALZHEIMERS RES THER, V13, DOI 10.1186/s13195-020-00761-9
   Cheng G, 2012, INTERN MED J, V42, P484, DOI 10.1111/j.1445-5994.2012.02758.x
   De Felice FG, 2014, DIABETES, V63, P2262, DOI 10.2337/db13-1954
   Deng J, 2018, J CELL MOL MED, V22, P546, DOI 10.1111/jcmm.13342
   Duca FA, 2015, NAT MED, V21, P506, DOI 10.1038/nm.3787
   Everard A, 2014, NAT COMMUN, V5, DOI 10.1038/ncomms6648
   Fang EF, 2019, NAT NEUROSCI, V22, P401, DOI 10.1038/s41593-018-0332-9
   Festa A, 2002, DIABETES, V51, P1131, DOI 10.2337/diabetes.51.4.1131
   Formiga F, 2014, ENDOCRINOL NUTR, V61, P173, DOI 10.1016/j.endonu.2014.03.001
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Fullerton MD, 2013, NAT MED, V19, P1649, DOI 10.1038/nm.3372
   Fung TC, 2017, NAT NEUROSCI, V20, P145, DOI 10.1038/nn.4476
   Garcia-Villalba R, 2013, J AGR FOOD CHEM, V61, P8797, DOI 10.1021/jf402498b
   Gasperotti M, 2015, ACS CHEM NEUROSCI, V6, P1341, DOI 10.1021/acschemneuro.5b00051
   Gong Z, 2019, J NEUROINFLAMM, V16, DOI 10.1186/s12974-019-1450-3
   Grivennikov SI, 2012, NATURE, V491, P254, DOI 10.1038/nature11465
   Hunter RW, 2018, NAT MED, V24, P1395, DOI 10.1038/s41591-018-0159-7
   Kesika P, 2021, LIFE SCI, V264, DOI 10.1016/j.lfs.2020.118627
   Landete JM, 2011, FOOD RES INT, V44, P1150, DOI 10.1016/j.foodres.2011.04.027
   Lee Hee Jae, 2018, Clin Nutr Res, V7, P229, DOI 10.7762/cnr.2018.7.4.229
   Lee HJ, 2021, CELL DEATH DIFFER, V28, P184, DOI 10.1038/s41418-020-0593-1
   Liu XN, 2021, CELL METAB, V33, P923, DOI 10.1016/j.cmet.2021.02.002
   Ma XY, 2021, BRAIN BEHAV IMMUN, V95, P68, DOI 10.1016/j.bbi.2021.02.011
   Madiraju AK, 2018, NAT MED, V24, P1384, DOI 10.1038/s41591-018-0125-4
   Muccioli GG, 2010, MOL SYST BIOL, V6, DOI 10.1038/msb.2010.46
   Nagai N, 2016, INVEST OPHTH VIS SCI, V57, P1408, DOI 10.1167/iovs.15-19026
   Nakamura A, 2020, ISCIENCE, V23, DOI 10.1016/j.isci.2020.101522
   Ohn JH, 2016, LANCET DIABETES ENDO, V4, P27, DOI 10.1016/S2213-8587(15)00336-8
   Palikaras K, 2018, NAT CELL BIOL, V20, P1013, DOI 10.1038/s41556-018-0176-2
   Pickup JC, 1997, DIABETOLOGIA, V40, P1286, DOI 10.1007/s001250050822
   Pradhan AD, 2001, JAMA-J AM MED ASSOC, V286, P327, DOI 10.1001/jama.286.3.327
   Pugazhenthi S, 2017, BBA-MOL BASIS DIS, V1863, P1037, DOI 10.1016/j.bbadis.2016.04.017
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Roden M, 2019, NATURE, V576, P51, DOI 10.1038/s41586-019-1797-8
   Roopchand DE, 2015, DIABETES, V64, P2847, DOI 10.2337/db14-1916
   Rotermund C, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00400
   Ryu D, 2016, NAT MED, V22, P879, DOI 10.1038/nm.4132
   Saleem YIM, 2020, EUR J NUTR, V59, P1607, DOI 10.1007/s00394-019-02016-2
   Sampson TR, 2016, CELL, V167, P1469, DOI 10.1016/j.cell.2016.11.018
   Sarkar SR, 2019, J NEUROIMMUNOL, V328, P98, DOI 10.1016/j.jneuroim.2019.01.004
   Savi M, 2017, CARDIOVASC DIABETOL, V16, DOI 10.1186/s12933-017-0561-3
   Seeram NP, 2007, J AGR FOOD CHEM, V55, P7732, DOI 10.1021/jf071303g
   Shao X, 2020, J AGR FOOD CHEM, V68, P12295, DOI 10.1021/acs.jafc.0c04773
   Shin NR, 2015, TRENDS BIOTECHNOL, V33, P496, DOI 10.1016/j.tibtech.2015.06.011
   Singh R, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-018-07859-7
   Sochocka M, 2019, MOL NEUROBIOL, V56, P1841, DOI 10.1007/s12035-018-1188-4
   Thaiss CA, 2018, SCIENCE, V359, P1376, DOI 10.1126/science.aar3318
   Thevaranjan N, 2017, CELL HOST MICROBE, V21, P455, DOI 10.1016/j.chom.2017.03.002
   TILG H, 2020, NAT REV IMMUNOL, V20, P40, DOI DOI 10.1038/S41577-019-0198-4
   Wei XC, 2012, CELL HOST MICROBE, V11, P140, DOI 10.1016/j.chom.2011.12.006
   Winer DA, 2016, CELL METAB, V23, P413, DOI 10.1016/j.cmet.2016.01.003
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Xia B, 2020, PLOS BIOL, V18, DOI 10.1371/journal.pbio.3000688
   Xu JL, 2018, J AGR FOOD CHEM, V66, P571, DOI 10.1021/acs.jafc.7b03285
   Yang JP, 2020, MOL NUTR FOOD RES, V64, DOI 10.1002/mnfr.202000091
   Zhang Q, 2020, DIABET METAB SYND OB, V13, P5003, DOI 10.2147/DMSO.S286430
   Zhang W, 2019, BIOMED PHARMACOTHER, V118, DOI 10.1016/j.biopha.2019.109131
NR 63
TC 7
Z9 6
U1 16
U2 56
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD MAY
PY 2022
VL 66
IS 9
AR 2100863
DI 10.1002/mnfr.202100863
EA MAR 2022
PG 18
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 0Z1WD
UT WOS:000762228000001
PM 35184377
DA 2023-06-08
ER

PT J
AU Yang, Y
   Liu, SL
   Wang, YH
   Wang, ZB
   Ding, WY
   Sun, XY
   He, KL
   Feng, Q
   Zhang, XD
AF Yang, Ying
   Liu, Shili
   Wang, Yihua
   Wang, Zhibin
   Ding, Wenyu
   Sun, Xiaoyuan
   He, Kunlun
   Feng, Qiang
   Zhang, Xiandang
TI Changes of saliva microbiota in the onset and after the treatment of
   diabetes in patients with periodontitis
SO AGING-US
LA English
DT Article
DE T2DM; salivary microbiota; treatment; differential bacteria; microbial
   markers
ID GUT-MICROBIOTA; INTESTINAL MICROBIOTA; INSULIN SENSITIVITY; ORAL
   MICROBIOME; TYPE-2; METFORMIN; MELLITUS; INDIVIDUALS; OBESITY;
   ASSOCIATION
AB The relationship between type 2 diabetes mellitus (T2DM) and oral microbiota is still insufficiently recognized. In the present study, we compared the salivary microbiome of nondiabetic individuals, treatment-naive diabetic patients, and diabetic patients treated with metformin or a combination of insulin and other drugs. The alpha- and beta-diversity demonstrated significant differences in the salivary microbiome between the nondiabetic people and patients with a history of diabetes, while little divergence was found among individuals with a history of diabetes. After characterizing the effects of periodontitis on the microbial composition of each group, the salivary microbiome of the treatment-naive diabetic patient group was compared with that of nondiabetic people and the metformin/combined treatment groups. The results revealed changes in the contents of certain bacteria after both the onset and the treatment of diabetes; among these differential bacteria, Blautia_wexlerae, Lactobacillus_fermentum, Nocardia_coeliaca and Selenomonas_artemidis varied in all processes. A subsequent correlational analysis of the differential bacteria and clinical characteristics demonstrated that salivary microbes were related to drug treatment and certain pathological changes. Finally, the four common differential bacteria were employed for distinguishing the treatment-naive diabetic patients from the nondiabetic people and the treated patients, with prediction accuracies of 83.3%, 75% and 75%, respectively.
C1 [Yang, Ying; Wang, Zhibin; Ding, Wenyu; Zhang, Xiandang] Shandong First Med Univ & Shandong Acad Med Sci, Endocrine & Metab Dis Hosp Shandong Med Univ 1, Jinan, Shandong, Peoples R China.
   [Liu, Shili; Wang, Yihua; Feng, Qiang] Shandong Univ, Sch & Hosp Stomatol, Dept Human Microbiome, Cheeloo Coll Med, Jinan, Shandong, Peoples R China.
   [Liu, Shili; Wang, Yihua; Feng, Qiang] Shandong Prov Key Lab Oral Tissue Regenerat, Jinan, Shandong, Peoples R China.
   [Liu, Shili; Wang, Yihua; Feng, Qiang] Shandong Engn Lab Dent Mat & Oral Tissue Regenera, Jinan, Shandong, Peoples R China.
   [Liu, Shili] Shandong Univ, Cheeloo Coll Med, Sch Basic Med Sci, Jinan, Shandong, Peoples R China.
   [Sun, Xiaoyuan] Shandong Univ Hosp, Jinan, Shandong, Peoples R China.
   [He, Kunlun] Chinese Peoples Liberat Army Gen Hosp, Beijing Key Lab Precis Med Chron Heart Failure, Beijing, Peoples R China.
   [Feng, Qiang] Shandong Univ, State Key Lab Microbial Technol, Qingdao, Shandong, Peoples R China.
C3 Shandong First Medical University & Shandong Academy of Medical
   Sciences; Shandong University; Shandong University; Shandong University;
   Chinese People's Liberation Army General Hospital; Shandong University
RP Zhang, XD (通讯作者)，Shandong First Med Univ & Shandong Acad Med Sci, Endocrine & Metab Dis Hosp Shandong Med Univ 1, Jinan, Shandong, Peoples R China.; Feng, Q (通讯作者)，Shandong Univ, Sch & Hosp Stomatol, Dept Human Microbiome, Cheeloo Coll Med, Jinan, Shandong, Peoples R China.; Feng, Q (通讯作者)，Shandong Prov Key Lab Oral Tissue Regenerat, Jinan, Shandong, Peoples R China.; Feng, Q (通讯作者)，Shandong Engn Lab Dent Mat & Oral Tissue Regenera, Jinan, Shandong, Peoples R China.; Feng, Q (通讯作者)，Shandong Univ, State Key Lab Microbial Technol, Qingdao, Shandong, Peoples R China.
EM fengqiang@sdu.edu.cn; xiandangzh@163.com
OI He, Kunlun/0000-0002-3335-5700
FU Innovation Project of Shandong Academy of Medical Sciences [2019-11];
   Shandong Province "Double-hundred Talent Plan" on 100 Foreign Experts
   and 100 Foreign Expert Teams Introduction [WST2018004]; Key Research and
   Development Program of Shandong Province [2018YYSP030]; National Natural
   Science Foundation of China [81630072]; Scientific and Technological
   Development Programme of Shandong Academy of Medical Sciences [2018-47];
   Fundamental Research Funds of Shandong University [2018JC102]; Natural
   Science of Shandong Province [ZR201702190185, 2018GSF118231]; Program of
   Qilu young scholars of Shandong University
FX We gratefully acknowledge the financial support from The Innovation
   Project of Shandong Academy of Medical Sciences (2019-11), Shandong
   Province "Double-hundred Talent Plan" on 100 Foreign Experts and 100
   Foreign Expert Teams Introduction (WST2018004), Key Research and
   Development Program of Shandong Province (2018YYSP030), The National
   Natural Science Foundation of China (No. 81630072), The Scientific and
   Technological Development Programme of Shandong Academy of Medical
   Sciences (2018-47), The Fundamental Research Funds of Shandong
   University (2018JC102), The Natural Science of Shandong Province (No.
   ZR201702190185 and No. 2018GSF118231), Program of Qilu young scholars of
   Shandong University. The funders had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript.
CR Abdolsamadi Hamidreza, 2014, J Dent Res Dent Clin Dent Prospects, V8, P160, DOI 10.5681/joddd.2014.029
   Aemaimanan P, 2013, ANAEROBE, V22, P64, DOI 10.1016/j.anaerobe.2013.06.010
   Amyot J, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0036200
   Barnes VM, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0105181
   Blasco-Baque V, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0048220
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   Caruso R, 2018, ACTA DIABETOL, V55, P1, DOI 10.1007/s00592-017-1071-1
   Casarin RCV, 2013, J PERIODONTAL RES, V48, P30, DOI 10.1111/j.1600-0765.2012.01498.x
   Castelino M, 2017, BMC MICROBIOL, V17, DOI 10.1186/s12866-017-0927-4
   Chee B, 2013, INT J EVID-BASED HEA, V11, P317, DOI 10.1111/1744-1609.12038
   Claesson MJ, 2010, NUCLEIC ACIDS RES, V38, DOI 10.1093/nar/gkq873
   Cui Y, 2014, EXP HEAT TRANSFER, V27, P213, DOI 10.1080/08916152.2012.757672
   Darveau RP, 2010, NAT REV MICROBIOL, V8, P481, DOI 10.1038/nrmicro2337
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Engebretson S, 2007, J CLIN PERIODONTOL, V34, P18, DOI 10.1111/j.1600-051X.2006.01017.x
   Engebretson SP, 2013, JAMA-J AM MED ASSOC, V310, P2523, DOI 10.1001/jama.2013.282431
   Fei N, 2013, ISME J, V7, P880, DOI 10.1038/ismej.2012.153
   FICARA AJ, 1975, J PERIODONTAL RES, V10, P171, DOI 10.1111/j.1600-0765.1975.tb00022.x
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Gao ZZ, 2017, J IMMUNOL RES, V2017, DOI 10.1155/2017/1813086
   Goodson JM, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0170437
   Janem WF, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0172647
   Kampoo K, 2014, APPL ENVIRON MICROB, V80, P662, DOI 10.1128/AEM.02821-13
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Knight ET, 2016, PERIODONTOL 2000, V71, P22, DOI 10.1111/prd.12110
   Kozich JJ, 2013, APPL ENVIRON MICROB, V79, P5112, DOI 10.1128/AEM.01043-13
   Lambeth Stacey M, 2015, J Diabetes Obes, V2, P1
   Long J, 2017, J PERIODONTAL RES, V52, P636, DOI 10.1111/jre.12432
   Makiura N, 2008, ORAL MICROBIOL IMMUN, V23, P348, DOI 10.1111/j.1399-302X.2007.00426.x
   Chavarry NGM, 2009, ORAL HLTH PREV DENT, V7, P107
   Mealey BL, 2006, J PERIODONTOL, V77, P1289, DOI 10.1902/jop.2006.050459
   Mulak A, 2015, WORLD J GASTROENTERO, V21, P10609, DOI 10.3748/wjg.v21.i37.10609
   Napolitano A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100778
   Ogurtsova K, 2017, DIABETES RES CLIN PR, V128, P40, DOI 10.1016/j.diabres.2017.03.024
   Aitken JP, 2015, DIS MARKERS, V2015, DOI 10.1155/2015/128653
   Pascale A, 2019, CURR OPIN PHARMACOL, V49, P1, DOI 10.1016/j.coph.2019.03.011
   Pickup JC, 1998, DIABETOLOGIA, V41, P1241, DOI 10.1007/s001250051058
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Sabharwal A, 2019, J PERIODONTOL, V90, P26, DOI 10.1002/JPER.18-0167
   Saeb ATM, 2019, MICROB PATHOGENESIS, V128, P215, DOI 10.1016/j.micpath.2019.01.009
   Satish B N V S, 2014, J Int Oral Health, V6, P114
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Takeshita T, 2009, ISME J, V3, P65, DOI 10.1038/ismej.2008.91
   Tilg H, 2008, MOL MED, V14, P222, DOI 10.2119/2007-00119.Tilg
   Tremblay M, 2011, J CAN DENT ASSOC, V77, P1
   Udayappan S, 2016, NPJ BIOFILMS MICROBI, V2, DOI 10.1038/npjbiofilms.2016.9
   Valentini L, 2015, CLIN NUTR, V34, P593, DOI 10.1016/j.clnu.2014.09.023
   Vrieze A, 2012, GASTROENTEROLOGY, V143, P913, DOI 10.1053/j.gastro.2012.06.031
   Wang Ke, 2018, Sichuan Da Xue Xue Bao Yi Xue Ban, V49, P408
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Xiao E, 2017, CELL HOST MICROBE, V22, P120, DOI 10.1016/j.chom.2017.06.014
   Zhao LP, 2018, SCIENCE, V359, P1151, DOI 10.1126/science.aao5774
   Zhou GC, 2001, J CLIN INVEST, V108, P1167, DOI 10.1172/JCI200113505
   Zhou M, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0061516
NR 54
TC 20
Z9 20
U1 1
U2 24
PU IMPACT JOURNALS LLC
PI ORCHARD PARK
PA 6666 E QUAKER ST, STE 1, ORCHARD PARK, NY 14127 USA
SN 1945-4589
J9 AGING-US
JI Aging-US
PD JUL 15
PY 2020
VL 12
IS 13
BP 13090
EP 13114
DI 10.18632/aging.103399
PG 25
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Geriatrics & Gerontology
GA MM0YN
UT WOS:000549885700006
PM 32634783
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Yan, N
   Wang, LJ
   Li, YW
   Wang, T
   Yang, LB
   Yan, R
   Wang, H
   Jia, SB
AF Yan, Ning
   Wang, Lijuan
   Li, Yiwei
   Wang, Ting
   Yang, Libo
   Yan, Ru
   Wang, Hao
   Jia, Shaobin
TI Metformin intervention ameliorates AS in ApoE(-/-) mice through
   restoring gut dysbiosis and anti-inflammation
SO PLOS ONE
LA English
DT Article
ID CHAIN FATTY-ACID; CORONARY-ARTERY-DISEASE; DIABETES-MELLITUS;
   MICROBIOTA; ATHEROSCLEROSIS; MACROPHAGES; PATHOGENESIS; CHOLESTEROL;
   AKKERMANSIA; MODULATION
AB Atherosclerosis (AS) is closely associated with chronic low-grade inflammation and gut dysbiosis. Metformin (MET) presents pleiotropic benefits in the control of chronic metabolic diseases, but the impacts of MET intervention on gut microbiota and inflammation in AS remain largely unclear. In this study, ApoE(-/-) mice with a high-fat diet (HFD) were adopted to assess the MET treatment. After 12 weeks of MET intervention (100mg center dot kg(-1)center dot d(-1)), relevant indications were investigated. As indicated by the pathological measurements, the atherosclerotic lesion was alleviated with MET intervention. Moreover, parameters in AS including body weights (BWs), low-density lipoprotein (LDL), triglyceride (TG), total cholesterol (TC) and malondialdehyde (MDA) were elevated; whereas high-density lipoprotein (HDL) and total superoxide dismutase (T-SOD) levels were decreased, which could be reversed by MET intervention. Elevated pro-inflammatory interleukin (IL)-1 beta, IL-6, tumor necrosis factor (TNF)-alpha and lipopolysaccaride (LPS) in AS were decreased after MET administration. However, anti-inflammatory IL-10 showed no significant difference between AS group and AS+MET group. Consistently, accumulated macrophages in the aorta of AS were conversely lowered with MET treatment. The results of 16S rRNA sequencing and analysis displayed that the overall community of gut microbiota in AS was notably changed with MET treatment mainly through decreasing Firmicutes, Proteobacteria, Romboutsia, Firmicutes/Bacteroidetes, as well as increasing Akkermansia, Bacteroidetes, Bifidobacterium. Additionally, we found that microbiota-derived short-chain fatty acids (SCFAs) including acetic acid, propionic acid, butyric acid and valeric acid in AS were decreased, which were significantly up-regulated with MET intervention. Consistent with the attenuation of MET on gut dysbiosis, decreased intestinal tight junction protein zonula occludens-1 (ZO)-1 in AS was restored after MET supplementation. Correlation analysis showed close relationships among gut bacteria, microbial metabolites SCFAs and inflammation. Collectively, MET intervention ameliorates AS in ApoE(-/-) mice through restoring gut dysbiosis and anti-inflammation, thus can potentially serve as an inexpensive and effective intervention for the control of the atherosclerotic cardiovascular disease.
C1 [Yan, Ning; Wang, Lijuan; Yang, Libo] Ningxia Med Univ, Clin Med Coll, Yinchuan, Ningxia, Peoples R China.
   [Yan, Ning; Yang, Libo; Yan, Ru; Jia, Shaobin] Ningxia Med Univ, Heart Ctr, Gen Hosp, Yinchuan, Ningxia, Peoples R China.
   [Yan, Ning; Yang, Libo; Yan, Ru; Jia, Shaobin] Ningxia Med Univ, Dept Cardiovasc Dis, Gen Hosp, Yinchuan, Ningxia, Peoples R China.
   [Wang, Lijuan] Second Hosp Yinchuan, Dept Cardiovasc Dis, Yinchuan, Ningxia, Peoples R China.
   [Li, Yiwei; Wang, Ting; Wang, Hao] Ningxia Med Univ, Sch Basic Med Sci, Dept Pathogen Biol & Med Immunol, Yinchuan, Ningxia, Peoples R China.
   [Yan, Ru; Jia, Shaobin] Ningxia Med Univ, Ningxia Key Lab Vasc Injury & Repair Res, Yinchuan, Ningxia, Peoples R China.
C3 Ningxia Medical University; Ningxia Medical University; Ningxia Medical
   University; Ningxia Medical University; Ningxia Medical University
RP Jia, SB (通讯作者)，Ningxia Med Univ, Heart Ctr, Gen Hosp, Yinchuan, Ningxia, Peoples R China.; Jia, SB (通讯作者)，Ningxia Med Univ, Dept Cardiovasc Dis, Gen Hosp, Yinchuan, Ningxia, Peoples R China.; Wang, H (通讯作者)，Ningxia Med Univ, Sch Basic Med Sci, Dept Pathogen Biol & Med Immunol, Yinchuan, Ningxia, Peoples R China.; Jia, SB (通讯作者)，Ningxia Med Univ, Ningxia Key Lab Vasc Injury & Repair Res, Yinchuan, Ningxia, Peoples R China.
EM wanghaograduate@126.com; jsbxn@163.com
FU Key Research and Development Projects of Ningxia, China [2018BEG02006];
   Natural Science Foundation of Ningxia, China [2018AAC03257]; National
   Natural Science Foundation, China [82060057]
FX This work was supported by the Key Research and Development Projects of
   Ningxia, China (Grant number 2018BEG02006); the Natural Science
   Foundation of Ningxia, China (Grant number 2021AAC05010); the National
   Natural Science Foundation, China (Grant number 82060057) and the
   Natural Science Foundation of Ningxia, China (Grant number
   2018AAC03257). The funders had no role in study design, data collection
   and analysis, decision to publish, or preparation of the manuscript.
CR Aroda Vanita R, 2018, Diabetes Spectr, V31, P336, DOI 10.2337/ds18-0020
   Bao T, 2020, FRONT PHARMACOL, V11, DOI 10.3389/fphar.2020.558525
   Barrington WT, 2017, NAT REV CARDIOL, V14, P699, DOI 10.1038/nrcardio.2017.169
   Benahmed AG, 2021, ANAEROBE, V70, DOI 10.1016/j.anaerobe.2020.102248
   Berbee JFP, 2017, ATHEROSCLEROSIS, V264, P100, DOI 10.1016/j.atherosclerosis.2017.06.916
   Brandsma E, 2019, CIRC RES, V124, P94, DOI 10.1161/CIRCRESAHA.118.313234
   Brown JM, 2018, NAT REV MICROBIOL, V16, P171, DOI 10.1038/nrmicro.2017.149
   Buldak L, 2014, PHARMACOL REP, V66, P418, DOI 10.1016/j.pharep.2013.11.008
   Cai ZJ, 2016, CIRC RES, V119, P422, DOI 10.1161/CIRCRESAHA.116.308301
   Cani PD, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.01765
   Chang MC, 2013, J PERIODONTAL RES, V48, P66, DOI 10.1111/j.1600-0765.2012.01504.x
   Chen ML, 2016, MBIO, V7, DOI 10.1128/mBio.02210-15
   Chen RZ, 2019, PHARMACOL RES, V148, DOI 10.1016/j.phrs.2019.104403
   Chen WJ, 2020, CLIN CHIM ACTA, V507, P236, DOI 10.1016/j.cca.2020.04.037
   Chen XF, 2020, CLIN SCI, V134, P657, DOI 10.1042/CS20200128
   Chen Y, 2019, INT REV IMMUNOL, V38, P249, DOI 10.1080/08830185.2019.1645138
   Cochain C, 2017, PFLUG ARCH EUR J PHY, V469, P485, DOI 10.1007/s00424-017-1941-y
   Correa RO, 2017, CELL MICROBIOL, V19, DOI 10.1111/cmi.12720
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   dos Santos JL, 2020, NUTRIENTS, V12, DOI 10.3390/nu12030682
   Duan YH, 2019, FASEB J, V33, P10019, DOI 10.1096/fj.201900665RR
   Emoto T, 2017, HEART VESSELS, V32, P39, DOI 10.1007/s00380-016-0841-y
   Emoto T, 2016, J ATHEROSCLER THROMB, V23, P908, DOI 10.5551/jat.32672
   Eppinga RN, 2017, CIRC-CARDIOVASC GENE, V10, DOI 10.1161/CIRCGENETICS.116.001564
   Forouzandeh F, 2014, J AM HEART ASSOC, V3, DOI 10.1161/JAHA.114.001202
   Geovanini GR, 2018, CLIN SCI, V132, P1243, DOI 10.1042/CS20180306
   Gopoju R, 2018, FREE RADICAL BIO MED, V118, P85, DOI 10.1016/j.freeradbiomed.2018.02.031
   Gui HB, 2016, J DAIRY SCI, V99, P6627, DOI 10.3168/jds.2015-10446
   Hutcheson R, 2012, EXP DIABETES RES, DOI 10.1155/2012/271028
   Jonsson AL, 2018, ARTERIOSCL THROM VAS, V38, P2318, DOI 10.1161/ATVBAHA.118.311233
   Jonsson AL, 2017, NAT REV CARDIOL, V14, P79, DOI 10.1038/nrcardio.2016.183
   Karlsson FH, 2012, NAT COMMUN, V3, DOI 10.1038/ncomms2266
   Kashi Z, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0151543
   Khosravi M, 2019, BIOL CHEM, V400, P711, DOI 10.1515/hsz-2018-0397
   Lacy M, 2019, PHARMACOL THERAPEUT, V193, P50, DOI 10.1016/j.pharmthera.2018.08.012
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Li FJ, 2020, J ETHNOPHARMACOL, V247, DOI 10.1016/j.jep.2019.112232
   Li Q, 2019, FOOD FUNCT, V10, P7174, DOI 10.1039/c9fo01465a
   Lian ZQ, 2020, ARTERIOSCL THROM VAS, V40, P72, DOI [10.1161/ATVBAHA.119.313078, 10.1161/ATVBAHA.119.313078.]
   Liang X, 2020, NUTRITION, V79-80, DOI 10.1016/j.nut.2020.110941
   Lin MY, 2015, FRONT IMMUNOL, V6, DOI 10.3389/fimmu.2015.00554
   Liu FS, 2021, J ETHNOPHARMACOL, V268, DOI 10.1016/j.jep.2020.113562
   Liu QX, 2020, MICROB PATHOGENESIS, V138, DOI 10.1016/j.micpath.2019.103827
   Ma A, 2017, J LIPID RES, V58, P1536, DOI 10.1194/jlr.M073270
   Moore KJ, 2013, NAT REV IMMUNOL, V13, P709, DOI 10.1038/nri3520
   Napolitano A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100778
   Ohira H, 2017, J ATHEROSCLER THROMB, V24, P660, DOI 10.5551/jat.RV17006
   Packard RRS, 2008, CLIN CHEM, V54, P24, DOI 10.1373/clinchem.2007.097360
   Pahwa R, 2017, J DIABETES RES, V2017, DOI 10.1155/2017/6519785
   Parhofer KG, 2016, DTSCH ARZTEBL INT, V113, P261, DOI 10.3238/arztebl.2016.0261
   Pascale A, 2019, CURR OPIN PHARMACOL, V49, P1, DOI 10.1016/j.coph.2019.03.011
   PENTIKAINEN PJ, 1990, ANN MED, V22, P307, DOI 10.3109/07853899009147912
   Pieczynska MD, 2020, MOLECULES, V25, DOI 10.3390/molecules25030594
   Raggi P, 2018, ATHEROSCLEROSIS, V276, P98, DOI 10.1016/j.atherosclerosis.2018.07.014
   Ryan PM, 2017, MICROBIOME, V5, DOI 10.1186/s40168-017-0246-x
   Sadeghi A, 2020, CHILD OBES, V16, P174, DOI 10.1089/chi.2019.0040
   Sanchez-Rodriguez E, 2020, NUTRIENTS, V12, DOI 10.3390/nu12030605
   Schulthess J, 2019, IMMUNITY, V50, P432, DOI 10.1016/j.immuni.2018.12.018
   Seneviratne A, 2021, CARDIOVASC RES, V117, P1295, DOI 10.1093/cvr/cvaa171
   Shah PK, 2019, TRENDS CARDIOVAS MED, V29, P468, DOI 10.1016/j.tcm.2019.01.004
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Sobenin IA, 2014, BIOMED RES INT, V2014, DOI 10.1155/2014/205697
   Sugita K, 2020, J LEUKOCYTE BIOL, V107, P749, DOI 10.1002/JLB.5MR0120-230R
   Sun MM, 2017, J GASTROENTEROL, V52, P1, DOI 10.1007/s00535-016-1242-9
   Tang G, 2019, BIOMED PHARMACOTHER, V119, DOI 10.1016/j.biopha.2019.109410
   Tunon J, 2018, EUR J PREV CARDIOL, V25, P948, DOI 10.1177/2047487318773384
   Wang QL, 2017, DIABETES, V66, P193, DOI 10.2337/db16-0915
   Wang T, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.00284
   Wang Z, 2020, INT IMMUNOPHARMACOL, V78, DOI 10.1016/j.intimp.2019.106062
   Weber C, 2011, NAT MED, V17, P1410, DOI 10.1038/nm.2538
   Wolf D, 2019, CIRC RES, V124, P315, DOI 10.1161/CIRCRESAHA.118.313591
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Wu MY, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18102034
   Wulffele MG, 2004, J INTERN MED, V256, P1, DOI 10.1111/j.1365-2796.2004.01328.x
   Xiao SW, 2019, J ETHNOPHARMACOL, V241, DOI 10.1016/j.jep.2019.112032
   Xu T, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/9030563
   Yang XL, 2019, ALCOHOL CLIN EXP RES, V43, P411, DOI 10.1111/acer.13950
   Yerevanian A, 2019, CURR OBES REP, V8, P156, DOI 10.1007/s13679-019-00335-3
   Yuan XX, 2018, REDOX BIOL, V16, P21, DOI 10.1016/j.redox.2018.02.007
   Zhang X, 2015, SCI REP-UK, V5, DOI 10.1038/srep14405
   Zhao L, 2018, BRIT MED BULL, V126, P101, DOI 10.1093/bmb/ldy006
   Zhou WY, 2020, OXID MED CELL LONGEV, V2020, DOI 10.1155/2020/5394096
   Zhou Y, 2017, MAR DRUGS, V15, DOI 10.3390/md15110358
   Zhu LL, 2020, LIPIDS HEALTH DIS, V19, DOI 10.1186/s12944-019-1167-4
   Zhu L, 2018, ATHEROSCLEROSIS, V268, P117, DOI 10.1016/j.atherosclerosis.2017.11.023
NR 85
TC 9
Z9 10
U1 1
U2 8
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUL 15
PY 2021
VL 16
IS 7
AR e0254321
DI 10.1371/journal.pone.0254321
PG 22
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA TQ2MX
UT WOS:000678120600002
PM 34264978
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Roessler, J
   Leistner, DM
   Landmesser, U
   Haghikia, A
AF Roessler, Johann
   Leistner, David M.
   Landmesser, Ulf
   Haghikia, Arash
TI Modulatory role of gut microbiota in cholesterol and glucose metabolism:
   Potential implications for atherosclerotic cardiovascular disease
   Atherosclerosis
SO ATHEROSCLEROSIS
LA English
DT Review
DE Gut microbiota; Cardiometabolic disease; Obesity; Hypercholesterolemia;
   Short chain fatty acids; Glucagon like peptide-1; Bile acids; Type II
   diabetes Mellitus; Statins; Metformin
ID CHAIN FATTY-ACIDS; GLUCAGON-LIKE PEPTIDE-1; TRIMETHYLAMINE-N-OXIDE;
   EPITHELIAL BARRIER FUNCTION; FARNESOID X RECEPTOR; BILE-ACID; INTESTINAL
   MICROBIOTA; INSULIN-RESISTANCE; LIPID-METABOLISM;
   AKKERMANSIA-MUCINIPHILA
AB Accumulating evidence suggests an important role of gut microbiota in physiological processes of host metabolism as well as cardiometabolic disease. Recent advances in metagenomic and metabolomic research have led to discoveries of novel pathways in which intestinal microbial metabolism of dietary nutrients is linked to metabolic profiles and cardiovascular disease risk. A number of metaorganismal circuits have been identified by microbiota transplantation studies and experimental models using germ-free rodents. Many of these pathways involve gut microbiota-related bioactive metabolites that impact host metabolism, in particular lipid and glucose homeostasis, partly via specific host receptors.In this review, we summarize the current knowledge of how the gut microbiome can impact cardiometabolic phenotypes and provide an overview of recent advances of gut microbiome research.Finally, the potential of modulating intestinal microbiota composition and/or targeting microbiota-related pathways for novel preventive and therapeutic strategies in cardiometabolic and cardiovascular diseases will be discussed.
C1 [Roessler, Johann; Leistner, David M.; Landmesser, Ulf; Haghikia, Arash] Charite Univ Med Berlin, Dept Cardiol, Campus Benjamin Franklin, Berlin, Germany.
   [Leistner, David M.; Landmesser, Ulf; Haghikia, Arash] DZHK German Ctr Cardiovasc Res, Partner Site Berlin, Berlin, Germany.
   [Leistner, David M.; Landmesser, Ulf; Haghikia, Arash] Berlin Inst Hlth BIH, Berlin, Germany.
   [Haghikia, Arash] Charite Univ Med Berlin, Dept Cardiol, Campus Benjamin Franklin Hindenburgdamm 30, D-12203 Berlin, Germany.
C3 Free University of Berlin; Humboldt University of Berlin; Charite
   Universitatsmedizin Berlin; German Centre for Cardiovascular Research;
   Berlin Institute of Health; Free University of Berlin; Humboldt
   University of Berlin; Charite Universitatsmedizin Berlin
RP Haghikia, A (通讯作者)，Charite Univ Med Berlin, Dept Cardiol, Campus Benjamin Franklin Hindenburgdamm 30, D-12203 Berlin, Germany.
EM arash.haghikia@charite.de
FU German Federal Ministry of Education and Research (BMBF) [01ZX1906B];
   German Research Foundation (DFG) [HA 6951/2-1]; Charite -
   Universitatsmedizin Berlin; Berlin Institute of Health
FX This study was supported by the Foundation Leducq network "Gut
   microbiome as a target for the treatment of cardiometabolic diseases",
   Sympath ("Systems-medicine of pneumonia-aggravated atherosclerosis",
   grant number 01ZX1906B) funded by the German Federal Ministry of
   Education and Research (BMBF), and the German Research Foundation (DFG,
   HA 6951/2-1). AH is participant in the BIH-Charite Advanced Clinician
   Scientist Pilotprogram funded by the Charite - Universitatsmedizin
   Berlin and the Berlin Institute of Health.
CR Backhed F, 2004, P NATL ACAD SCI USA, V101, P15718, DOI 10.1073/pnas.0407076101
   Backhed F, 2005, SCIENCE, V307, P1915, DOI 10.1126/science.1104816
   Bailey CJ, 2008, DIABETOLOGIA, V51, P1552, DOI 10.1007/s00125-008-1053-5
   Bennett BJ, 2013, CELL METAB, V17, P49, DOI 10.1016/j.cmet.2012.12.011
   Bermingham EN, 2017, PEERJ, V5, DOI 10.7717/peerj.3019
   Boekholdt SM, 2014, J AM COLL CARDIOL, V64, P485, DOI 10.1016/j.jacc.2014.02.615
   Breton J, 2016, CELL METAB, V23, P324, DOI 10.1016/j.cmet.2015.10.017
   Brown JM, 2018, NAT REV MICROBIOL, V16, P171, DOI 10.1038/nrmicro.2017.149
   Buse JB, 2016, DIABETES CARE, V39, P198, DOI 10.2337/dc15-0488
   Cani PD, 2016, MOL METAB, V5, P743, DOI 10.1016/j.molmet.2016.05.011
   Catry E, 2015, LIFE SCI, V132, P77, DOI 10.1016/j.lfs.2015.04.004
   Chambers ES, 2015, GUT, V64, P1744, DOI 10.1136/gutjnl-2014-307913
   Chang PV, 2014, P NATL ACAD SCI USA, V111, P2247, DOI 10.1073/pnas.1322269111
   Cosentino F, 2020, EUR HEART J, V41, P255, DOI [10.1093/eurheartj/ehz486, DOI 10.1093/EURHEARTJ/EHZ486, 10.1093/eurheartj/eht108]
   Crovesy L, 2020, EUR J CLIN NUTR, V74, P1251, DOI 10.1038/s41430-020-0607-6
   Dao MC, 2016, GUT, V65, P426, DOI 10.1136/gutjnl-2014-308778
   de Groot P, 2021, GUT, V70, P92, DOI [10.1136/gutjnl-2020-322630, 10.1136/gutjnl-2020-323252]
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   den Besten G, 2013, AM J PHYSIOL-GASTR L, V305, pG900, DOI 10.1152/ajpgi.00265.2013
   Depommier C, 2019, NAT MED, V25, P1096, DOI 10.1038/s41591-019-0495-2
   Ding LL, 2016, HEPATOLOGY, V64, P760, DOI 10.1002/hep.28689
   Dingeo G, 2020, FOOD FUNCT, V11, P8444, DOI [10.1039/d0fo01483d, 10.1039/D0FO01483D]
   Drucker DJ, 2016, CELL METAB, V24, P15, DOI 10.1016/j.cmet.2016.06.009
   Ducastel S, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-019-56743-x
   Duncan SH, 2008, INT J OBESITY, V32, P1720, DOI 10.1038/ijo.2008.155
   Duscha A, 2020, CELL, V180, P1067, DOI 10.1016/j.cell.2020.02.035
   Eckburg PB, 2005, SCIENCE, V308, P1635, DOI 10.1126/science.1110591
   Einarson TR, 2018, CARDIOVASC DIABETOL, V17, DOI 10.1186/s12933-018-0728-6
   Emoto T, 2016, J ATHEROSCLER THROMB, V23, P908, DOI 10.5551/jat.32672
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Feng Q, 2016, SCI REP-UK, V6, DOI 10.1038/srep22525
   Ference BA, 2018, J AM COLL CARDIOL, V72, P1141, DOI 10.1016/j.jacc.2018.06.046
   Ference BA, 2017, EUR HEART J, V38, P2459, DOI 10.1093/eurheartj/ehx144
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Fu JY, 2015, CIRC RES, V117, P817, DOI 10.1161/CIRCRESAHA.115.306807
   Garcia-Montero C, 2021, NUTRIENTS, V13, DOI 10.3390/nu13020699
   Gaudier E, 2004, AM J PHYSIOL-GASTR L, V287, pG1168, DOI 10.1152/ajpgi.00219.2004
   Gerard P, 2014, PATHOGENS, V3, P14, DOI 10.3390/pathogens3010014
   Gerstein HC, 2012, NEW ENGL J MED, V367, P319, DOI 10.1056/NEJMoa1203858
   Grant PJ, 2019, EUR HEART J, V40, P3215, DOI 10.1093/eurheartj/ehz687
   Green JB, 2015, NEW ENGL J MED, V373, P232, DOI 10.1056/NEJMoa1501352
   Guida F, 2020, BRAIN BEHAV IMMUN, V85, P128, DOI 10.1016/j.bbi.2019.04.006
   Guo CF, 2013, INT DAIRY J, V32, P144, DOI 10.1016/j.idairyj.2013.04.001
   Haffner SM, 1998, NEW ENGL J MED, V339, P229, DOI 10.1056/NEJM199807233390404
   Haghikia A, 2022, EUR HEART J, V43, P518, DOI 10.1093/eurheartj/ehab644
   Hatakka K, 2008, INT J FOOD MICROBIOL, V128, P406, DOI 10.1016/j.ijfoodmicro.2008.09.010
   Heianza Y, 2017, J AM HEART ASSOC, V6, DOI 10.1161/JAHA.116.004947
   Helmstadter J, 2020, ARTERIOSCL THROM VAS, V40, P145, DOI 10.1161/atv.0000615456.97862.30
   Hill MJ, 1997, EUR J CANCER PREV, V6, pS43, DOI 10.1097/00008469-199703001-00009
   Hogan AE, 2014, DIABETOLOGIA, V57, P781, DOI 10.1007/s00125-013-3145-0
   Home PD, 2009, LANCET, V373, P2125, DOI 10.1016/S0140-6736(09)60953-3
   Huang FJ, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-12896-x
   Huang XC, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-15044-x
   Huang Y, 2013, J DAIRY SCI, V96, P2816, DOI 10.3168/jds.2012-6371
   Huang Y, 2010, BRIT J NUTR, V103, P473, DOI 10.1017/S0007114509991991
   Inagaki T, 2005, CELL METAB, V2, P217, DOI 10.1016/j.cmet.2005.09.001
   Jie ZY, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-00900-1
   Jones BV, 2008, P NATL ACAD SCI USA, V105, P13580, DOI 10.1073/pnas.0804437105
   Jonsson AL, 2018, ARTERIOSCL THROM VAS, V38, P2318, DOI 10.1161/ATVBAHA.118.311233
   Joyce SA, 2014, P NATL ACAD SCI USA, V111, P7421, DOI 10.1073/pnas.1323599111
   Karpe F, 2011, DIABETES, V60, P2441, DOI 10.2337/db11-0425
   Kelly CJ, 2015, CELL HOST MICROBE, V17, P662, DOI 10.1016/j.chom.2015.03.005
   Khan TJ, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-017-19013-2
   Kim J, 2019, FRONT MICROBIOL, V10, DOI 10.3389/fmicb.2019.01947
   Kimura I, 2011, P NATL ACAD SCI USA, V108, P8030, DOI 10.1073/pnas.1016088108
   Kiouptsi K, 2019, MBIO, V10, DOI 10.1128/mBio.02298-19
   Kockx M, 2018, CURR OPIN LIPIDOL, V29, P484, DOI 10.1097/MOL.0000000000000558
   Koeth RA, 2013, NAT MED, V19, P576, DOI 10.1038/nm.3145
   Koh A, 2018, CELL, V175, P947, DOI 10.1016/j.cell.2018.09.055
   Koh A, 2016, CELL, V165, P1332, DOI 10.1016/j.cell.2016.05.041
   Kong B, 2012, HEPATOLOGY, V56, P1034, DOI 10.1002/hep.25740
   Koopen A., 2021, DUODENAL ANAEROBUTYR
   Kootte RS, 2017, CELL METAB, V26, P611, DOI 10.1016/j.cmet.2017.09.008
   Kumar M, 2012, EXP DIABETES RES, DOI 10.1155/2012/902917
   Le Roy T, 2019, BMC BIOL, V17, DOI 10.1186/s12915-019-0715-8
   Lee DK, 2009, LIPIDS HEALTH DIS, V8, DOI 10.1186/1476-511X-8-21
   Lee S, 2016, BIOCHEM BIOPH RES CO, V478, P1242, DOI 10.1016/j.bbrc.2016.08.101
   Ley RE, 2005, P NATL ACAD SCI USA, V102, P11070, DOI 10.1073/pnas.0504978102
   Ley RE, 2008, SCIENCE, V320, P1647, DOI 10.1126/science.1155725
   Ley RE, 2006, NATURE, V444, P1022, DOI 10.1038/4441022a
   Li F, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms3384
   LI L, 1995, LETT APPL MICROBIOL, V20, P137, DOI 10.1111/j.1472-765X.1995.tb00410.x
   Li R., 2021, JLR J LIPID RES, P62
   Li X, 2019, FOOD FUNCT, V10, P775, DOI 10.1039/c8fo02271b
   Liou AP, 2013, SCI TRANSL MED, V5, DOI 10.1126/scitranslmed.3005687
   Liu HJ, 2018, J DIABETES INVEST, V9, P13, DOI 10.1111/jdi.12687
   Liu RX, 2017, NAT MED, V23, P859, DOI 10.1038/nm.4358
   Lye HS, 2010, J DAIRY SCI, V93, P1383, DOI 10.3168/jds.2009-2574
   Macfarlane GT, 2012, J AOAC INT, V95, P50, DOI 10.5740/jaoacint.SGE_Macfarlane
   Mach F, 2020, EUR HEART J, V41, P111, DOI 10.1093/eurheartj/ehz455
   Marques TM, 2016, BENEF MICROBES, V7, P409, DOI 10.3920/BM2015.0154
   Marso SP, 2016, NEW ENGL J MED, V375, P1834, DOI 10.1056/NEJMoa1607141
   Marso SP, 2016, NEW ENGL J MED, V375, P311, DOI 10.1056/NEJMoa1603827
   Masui R, 2013, INFLAMM BOWEL DIS, V19, P2848, DOI 10.1097/01.MIB.0000435444.14860.ea
   MCNEIL NI, 1984, AM J CLIN NUTR, V39, P338, DOI 10.1093/ajcn/39.2.338
   Miremadi F, 2014, J FUNCT FOODS, V9, P295, DOI 10.1016/j.jff.2014.05.002
   Molinaro A, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-19589-w
   Mortensen PB, 1996, SCAND J GASTROENTERO, V31, P132, DOI 10.3109/00365529609094568
   Mounien L, 2019, NUTRIENTS, V11, DOI 10.3390/nu11071562
   Muegge BD, 2011, SCIENCE, V332, P970, DOI 10.1126/science.1198719
   Mueller M, 2015, J HEPATOL, V62, P1398, DOI 10.1016/j.jhep.2014.12.034
   Nagatomo Y, 2015, J CARD FAIL, V21, P973, DOI 10.1016/j.cardfail.2015.09.017
   Neves AL, 2013, J MOL ENDOCRINOL, V51, pR51, DOI 10.1530/JME-13-0079
   Newgard CB, 2009, CELL METAB, V9, P311, DOI 10.1016/j.cmet.2009.02.002
   Out C, 2015, J HEPATOL, V63, P697, DOI 10.1016/j.jhep.2015.04.030
   Park YH, 2008, BIOSCI BIOTECH BIOCH, V72, P595, DOI 10.1271/bbb.70581
   Park YH, 2007, J MICROBIOL BIOTECHN, V17, P655
   Pathak P, 2020, AM J PHYSIOL-HEART C, V318, pH1474, DOI 10.1152/ajpheart.00584.2019
   Patti ME, 2009, OBESITY, V17, P1671, DOI 10.1038/oby.2009.102
   Pedersen HK, 2016, NATURE, V535, P376, DOI 10.1038/nature18646
   Pi-Sunyer X, 2015, NEW ENGL J MED, V373, P11, DOI 10.1056/NEJMoa1411892
   Pingitore A, 2017, DIABETES OBES METAB, V19, P257, DOI 10.1111/dom.12811
   Pluznick JL, 2013, P NATL ACAD SCI USA, V110, P4410, DOI 10.1073/pnas.1215927110
   Porreca E, 2002, J AM COLL CARDIOL, V39, P1752, DOI 10.1016/S0735-1097(02)01857-0
   Psichas A, 2015, INT J OBESITY, V39, P424, DOI 10.1038/ijo.2014.153
   Pyke C, 2013, ENDOCRINOLOGY, V154, P4, DOI 10.1210/en.2012-2124
   Qi JQ, 2018, J CELL MOL MED, V22, P185, DOI 10.1111/jcmm.13307
   Qin JJ, 2010, NATURE, V464, P59, DOI 10.1038/nature08821
   Rakipovski G, 2018, JACC-BASIC TRANSL SC, V3, P844, DOI 10.1016/j.jacbts.2018.09.004
   Reimer RA, 1996, ENDOCRINOLOGY, V137, P3948, DOI 10.1210/en.137.9.3948
   Rena G, 2017, DIABETOLOGIA, V60, P1577, DOI 10.1007/s00125-017-4342-z
   Ridaura VK, 2013, SCIENCE, V341, P1079, DOI 10.1126/science.1241214
   Ridlon JM, 2006, J LIPID RES, V47, P241, DOI 10.1194/jlr.R500013-JLR200
   Roberts LD, 2014, LANCET DIABETES ENDO, V2, P65, DOI 10.1016/S2213-8587(13)70143-8
   Roberts RE, 2011, CLIN ENDOCRINOL, V74, P67, DOI 10.1111/j.1365-2265.2010.03886.x
   Rotter V, 2003, J BIOL CHEM, V278, P45777, DOI 10.1074/jbc.M301977200
   Rubino F, 2004, ANN SURG, V240, P236, DOI 10.1097/01.sla.0000133117.12646.48
   Sandoval DA, 2015, PHYSIOL REV, V95, P513, DOI 10.1152/physrev.00013.2014
   SAVAGE DC, 1977, ANNU REV MICROBIOL, V31, P107, DOI 10.1146/annurev.mi.31.100177.000543
   Sayin SI, 2013, CELL METAB, V17, P225, DOI 10.1016/j.cmet.2013.01.003
   Schele E, 2013, ENDOCRINOLOGY, V154, P3643, DOI 10.1210/en.2012-2151
   Schwiertz A, 2010, OBESITY, V18, P190, DOI 10.1038/oby.2009.167
   Sender R, 2016, PLOS BIOL, V14, DOI 10.1371/journal.pbio.1002533
   Smith PM, 2013, SCIENCE, V341, P569, DOI 10.1126/science.1241165
   Sonnenburg JL, 2016, NATURE, V535, P56, DOI 10.1038/nature18846
   Sridharan GV, 2014, NAT COMMUN, V5, DOI 10.1038/ncomms6492
   Stancu C, 2001, J CELL MOL MED, V5, P378, DOI 10.1111/j.1582-4934.2001.tb00172.x
   Stancu CS, 2014, MOL NUTR FOOD RES, V58, P559, DOI 10.1002/mnfr.201300224
   Stepankova R, 2010, J ATHEROSCLER THROMB, V17, P796, DOI 10.5551/jat.3285
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Sun XW, 2020, J AGR FOOD CHEM, V68, P5118, DOI 10.1021/acs.jafc.0c01467
   Takahashi S, 2016, J LIPID RES, V57, P2130, DOI 10.1194/jlr.M071183
   Tang WHW, 2019, J AM COLL CARDIOL, V73, P2089, DOI 10.1016/j.jacc.2019.03.024
   Thaler JP, 2012, J CLIN INVEST, V122, P153, DOI 10.1172/JCI59660
   Tian LL, 2016, J DIABETES, V8, P753, DOI 10.1111/1753-0407.12439
   Tolhurst G, 2012, DIABETES, V61, P364, DOI 10.2337/db11-1019
   Trabelsi MS, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms8629
   Tremaroli V, 2012, NATURE, V489, P242, DOI 10.1038/nature11552
   Trenteseaux C, 2017, ARTERIOSCL THROM VAS, V37, P2053, DOI 10.1161/ATVBAHA.117.309923
   Tsiantas K, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23084070
   Turnbaugh PJ, 2008, CELL HOST MICROBE, V3, P213, DOI 10.1016/j.chom.2008.02.015
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Turnbaugh PJ, 2009, NATURE, V457, P480, DOI 10.1038/nature07540
   Valdearcos M, 2014, CELL REP, V9, P2124, DOI 10.1016/j.celrep.2014.11.018
   van der Wulp MYM, 2013, MOL CELL ENDOCRINOL, V368, P1, DOI 10.1016/j.mce.2012.06.007
   Velagapudi VR, 2010, J LIPID RES, V51, P1101, DOI 10.1194/jlr.M002774
   Vieira-Silva S, 2020, NATURE, V581, P310, DOI 10.1038/s41586-020-2269-x
   Vinolo MAR, 2011, J NUTR BIOCHEM, V22, P849, DOI 10.1016/j.jnutbio.2010.07.009
   Vrieze A, 2012, GASTROENTEROLOGY, V143, P913, DOI 10.1053/j.gastro.2012.06.031
   Wang HB, 2012, DIGEST DIS SCI, V57, P3126, DOI 10.1007/s10620-012-2259-4
   Wang TJ, 2011, NAT MED, V17, P448, DOI 10.1038/nm.2307
   Whitman WB, 1998, P NATL ACAD SCI USA, V95, P6578, DOI 10.1073/pnas.95.12.6578
   Wikoff WR, 2009, P NATL ACAD SCI USA, V106, P3698, DOI 10.1073/pnas.0812874106
   WILCOCK C, 1994, XENOBIOTICA, V24, P49, DOI 10.3109/00498259409043220
   WOLEVER TMS, 1995, AM J CLIN NUTR, V61, P1241, DOI 10.1093/ajcn/61.6.1241
   Wu GD, 2011, SCIENCE, V334, P105, DOI 10.1126/science.1208344
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Xia H, 2018, CANCER PREV RES, V11, P797, DOI 10.1158/1940-6207.CAPR-18-0188
   Young SG, 2012, NEW ENGL J MED, V366, P1154, DOI 10.1056/NEJMe1202168
   Yusta B, 2015, DIABETES, V64, P2537, DOI 10.2337/db14-1577
   Zanotti I, 2015, APPL MICROBIOL BIOT, V99, P6813, DOI 10.1007/s00253-015-6564-7
   Zhao LP, 2018, SCIENCE, V359, P1151, DOI 10.1126/science.aao5774
   Zheng L, 2017, J IMMUNOL, V199, P2976, DOI 10.4049/jimmunol.1700105
   Zimmermann F, 2020, J CLIN MED, V9, DOI 10.3390/jcm9051596
NR 174
TC 3
Z9 3
U1 14
U2 16
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD OCT
PY 2022
VL 359
BP 1
EP 12
DI 10.1016/j.atherosclerosis.2022.08.018
PG 12
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 6I3JQ
UT WOS:000886025100001
PM 36126379
DA 2023-06-08
ER

PT J
AU Wu, WK
   Ivanova, EA
   Orekhov, AN
AF Wu, Wei-Kai
   Ivanova, Ekaterina A.
   Orekhov, Alexander N.
TI Gut microbiome: A possible common therapeutic target for treatment of
   atherosclerosis and cancer
SO SEMINARS IN CANCER BIOLOGY
LA English
DT Article
DE Atherosclerosis; Cancer; Gut microbiota; Inflammation; Nutraceuticals
ID CHAIN FATTY-ACIDS; E-KNOCKOUT MICE; INTESTINAL MICROBIOTA; METABOLITE
   BUTYRATE; GERM-FREE; COMMENSAL BACTERIA; METFORMIN ALTERS; STATIN
   THERAPY; L-CARNITINE; BILE-ACID
AB Human gut microbiota is a dynamic and variable system that can change over time and in response to different diets and treatments. There is currently no doubt that gut microbiota can provide interesting therapeutic opportunities, since it can metabolize biologically active molecules, drugs, and their precursors, and control their bioavailability. Moreover, it can produce both beneficial and dangerous metabolites that influence host?s health. In this review, we summarize the current knowledge on the involvement of gut microbiota in two chronic human pathologies that represent the greatest challenges of modern medicine: atherosclerosis and cancer. Interesting parallels are observed between the mechanisms and possible treatment approaches of these pathologies. Some of the common effects of therapeutic agents targeting both pathologies, such as anti-inflammatory activity, are partially mediated by the gut microbiota. We will discuss the effects of common drugs (metformin, statins and aspirin) and various nutraceuticals on gut microbiota and outline the pathways of microbial involvement in mediating the pleiotropic beneficial effects of these agents in atherosclerosis and cancer.
C1 [Wu, Wei-Kai] Natl Taiwan Univ Hosp, Bei Hu Branch, Dept Internal Med, Taipei, Taiwan.
   [Ivanova, Ekaterina A.] Inst Atherosclerosis Res, Moscow 121609, Russia.
   [Orekhov, Alexander N.] Inst Gen Pathol & Pathophysiol, Lab Angiopathol, Moscow 125315, Russia.
   [Orekhov, Alexander N.] Inst Human Morphol, Tsyurupa Str 3, Moscow 117418, Russia.
C3 National Taiwan University; National Taiwan University Hospital; Russian
   Academy of Medical Sciences; Institute of General Pathology &
   Pathophysiology, RAMS; Russian Academy of Medical Sciences; Research
   Institute of Human Morphology
RP Ivanova, EA (通讯作者)，Inst Atherosclerosis Res, Moscow 121609, Russia.; Orekhov, AN (通讯作者)，Inst Human Morphol, Tsyurupa Str 3, Moscow 117418, Russia.
EM kate.ivanov@gmail.com; a.h.opexob@gmail.com
RI Wu, Wei-Kai/AAK-9631-2021
OI Wu, Wei-Kai/0000-0002-9476-8998
FU Russian Science Foundation [18-15-00254]
FX This work was supported by Russian Science Foundation (Grant
   #18-15-00254) .
CR Abreu MT, 2010, NAT REV IMMUNOL, V10, P131, DOI 10.1038/nri2707
   Afzal MZ, 2018, J IMMUNOTHER CANCER, V6, DOI 10.1186/s40425-018-0375-1
   Arnett DK, 2019, CIRCULATION, V140, pE563, DOI [10.1161/CIR.0000000000000677, 10.1016/j.jacc.2019.03.010, 10.1161/CIR.0000000000000678, 10.1016/j.jacc.2019.03.009]
   Arpaia N, 2013, NATURE, V504, P451, DOI 10.1038/nature12726
   Atarashi K, 2013, NATURE, V500, P232, DOI 10.1038/nature12331
   Becker N, 2011, GUT MICROBES, V2, P25, DOI 10.4161/gmic.2.1.14651
   Bjarnason I, 2018, GASTROENTEROLOGY, V154, P500, DOI 10.1053/j.gastro.2017.10.049
   Bolognini D, 2016, MOL PHARMACOL, V89, P388, DOI 10.1124/mol.115.102301
   Borgquist S, 2018, J INTERN MED, V284, P346, DOI 10.1111/joim.12806
   Bromage DI, 2015, CARDIOVASC DIABETOL, V14, DOI 10.1186/s12933-015-0273-5
   Bryrup T, 2019, DIABETOLOGIA, V62, P1024, DOI 10.1007/s00125-019-4848-7
   Buse JB, 2016, DIABETES CARE, V39, P198, DOI 10.2337/dc15-0488
   Caesar R, 2015, CELL METAB, V22, P658, DOI 10.1016/j.cmet.2015.07.026
   Cai Y, 2020, BRIT J PHARMACOL, V177, P1363, DOI 10.1111/bph.14871
   Calvo M. J., 2017, VESSEL PLUS, V1, P116, DOI [10.20517/2574-1209.2017.14, DOI 10.20517/2574-1209.2017.14]
   Campbell EL, 2019, NAT REV GASTRO HEPAT, V16, P106, DOI 10.1038/s41575-018-0079-5
   Canfora EE, 2019, NAT REV ENDOCRINOL, V15, P261, DOI 10.1038/s41574-019-0156-z
   Canfora EE, 2015, NAT REV ENDOCRINOL, V11, P577, DOI 10.1038/nrendo.2015.128
   Cani PD, 2018, GUT, V67, P1716, DOI 10.1136/gutjnl-2018-316723
   Cani PD, 2018, NAT REV GASTRO HEPAT, V15, P671, DOI 10.1038/s41575-018-0025-6
   Caparros-Martin JA, 2017, MICROBIOME, V5, DOI 10.1186/s40168-017-0312-4
   Cefalu WT, 2019, DIABETES CARE, V42, pS103, DOI 10.2337/dc19S010
   Chan AT, 2019, GASTROENTEROLOGY, V156, P534, DOI 10.1053/j.gastro.2018.11.063
   Chang PV, 2014, P NATL ACAD SCI USA, V111, P2247, DOI 10.1073/pnas.1322269111
   Chaplin A, 2018, NUTRIENTS, V10, DOI 10.3390/nu10111651
   Chen ML, 2016, MBIO, V7, DOI 10.1128/mBio.02210-15
   Cordain L, 2005, AM J CLIN NUTR, V81, P341, DOI 10.1093/ajcn.81.2.341
   Costantini L, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18122645
   Dalile B, 2019, NAT REV GASTRO HEPAT, V16, P461, DOI 10.1038/s41575-019-0157-3
   DeFronzo RA, 2016, DIABETOLOGIA, V59, P1645, DOI 10.1007/s00125-016-3992-6
   Diakos CI, 2014, LANCET ONCOL, V15, pE493, DOI 10.1016/S1470-2045(14)70263-3
   Dolara P, 2005, MUTAT RES-FUND MOL M, V591, P237, DOI 10.1016/j.mrfmmm.2005.04.022
   Duca FA, 2015, NAT MED, V21, P506, DOI 10.1038/nm.3787
   Eikawa S, 2015, P NATL ACAD SCI USA, V112, P1809, DOI 10.1073/pnas.1417636112
   Elfoul L, 2001, FEMS MICROBIOL LETT, V197, P99, DOI 10.1111/j.1574-6968.2001.tb10589.x
   Eteberria U, 2015, J NUTR BIOCHEM, V26, P651, DOI 10.1016/j.jnutbio.2015.01.002
   Farag MA, 2020, J ADV RES, V23, P47, DOI 10.1016/j.jare.2020.01.001
   Faria A, 2014, J AGR FOOD CHEM, V62, P6898, DOI 10.1021/jf501808a
   Fischbach MA, 2018, CELL, V174, P785, DOI 10.1016/j.cell.2018.07.038
   Foretz M, 2019, NAT REV ENDOCRINOL, V15, P569, DOI 10.1038/s41574-019-0242-2
   Foretz M, 2014, CELL METAB, V20, P953, DOI 10.1016/j.cmet.2014.09.018
   Frost G, 2014, NAT COMMUN, V5, DOI 10.1038/ncomms4611
   Fu ZD, 2014, J LIPID RES, V55, P2576, DOI 10.1194/jlr.M053124
   Galland L, 2010, NUTR CLIN PRACT, V25, P634, DOI 10.1177/0884533610385703
   Geovanini GR, 2018, CLIN SCI, V132, P1243, DOI 10.1042/CS20180306
   Ghosh SS, 2020, J ENDOCR SOC, V4, DOI 10.1210/jendso/bvz039
   Gopalakrishnan V, 2018, SCIENCE, V359, P97, DOI 10.1126/science.aan4236
   Grazioli S, 2018, FRONT IMMUNOL, V9, DOI 10.3389/fimmu.2018.00832
   Greenhill C, 2018, NAT REV ENDOCRINOL, V15, P2, DOI 10.1038/s41574-018-0133-y
   Haiser HJ, 2013, SCIENCE, V341, P295, DOI 10.1126/science.1235872
   Hamer HM, 2008, ALIMENT PHARM THER, V27, P104, DOI 10.1111/j.1365-2036.2007.03562.x
   Han YC, 2019, CARDIOVASC DIABETOL, V18, DOI 10.1186/s12933-019-0900-7
   Hassanabad AF, 2019, TRANSL LUNG CANCER R, V8, P692, DOI 10.21037/tlcr.2019.09.08
   Hecht SS, 2000, DRUG METAB REV, V32, P395, DOI 10.1081/DMR-100102342
   Hinnebusch BF, 2002, J NUTR, V132, P1012, DOI 10.1093/jn/132.5.1012
   Huttenhower C, 2012, NATURE, V486, P207, DOI 10.1038/nature11234
   Iatsenko I, 2018, IMMUNITY, V49, P929, DOI 10.1016/j.immuni.2018.09.017
   Ji J, 2016, SCI REP-UK, V6, DOI 10.1038/srep24838
   Kawabata K, 2019, MOLECULES, V24, DOI 10.3390/molecules24020370
   Kim J, 2019, FRONT MICROBIOL, V10, DOI 10.3389/fmicb.2019.01947
   Koeth RA, 2019, J CLIN INVEST, V129, P373, DOI 10.1172/JCI94601
   Koeth RA, 2014, CELL METAB, V20, P799, DOI 10.1016/j.cmet.2014.10.006
   Koeth RA, 2013, NAT MED, V19, P576, DOI 10.1038/nm.3145
   Koppel N, 2018, ELIFE, V7, DOI [10.7554/eLife.33953, 10.7554/elife.33953]
   Koppel N, 2017, SCIENCE, V356, DOI 10.1126/science.aag2770
   Krul C, 2002, CARCINOGENESIS, V23, P1009, DOI 10.1093/carcin/23.6.1009
   Lam KN, 2019, CELL HOST MICROBE, V26, P22, DOI 10.1016/j.chom.2019.06.011
   Laparra JM, 2010, PHARMACOL RES, V61, P219, DOI 10.1016/j.phrs.2009.11.001
   Le Bastard Q, 2018, ALIMENT PHARM THER, V47, P332, DOI 10.1111/apt.14451
   Lecuyer E, 2014, IMMUNITY, V40, P608, DOI 10.1016/j.immuni.2014.03.009
   Lee MS, 2011, BMC CANCER, V11, DOI 10.1186/1471-2407-11-20
   Lee YK, 2009, EXP MOL MED, V41, P201, DOI 10.3858/emm.2009.41.3.023
   Li F, 2011, BRIT J NUTR, V106, P408, DOI 10.1017/S0007114511000274
   Li WD, 2015, ONCOTARGET, V6, P7365, DOI 10.18632/oncotarget.3629
   Liu SJ, 2018, J SCI FOOD AGR, V98, P5816, DOI 10.1002/jsfa.9131
   Liu TY, 2012, ANAEROBE, V18, P331, DOI 10.1016/j.anaerobe.2012.02.004
   Liu X, 2016, CELL METAB, V24, P1
   Liu XJ, 2017, NUTRIENTS, V9, DOI 10.3390/nu9030262
   Loke WM, 2010, ARTERIOSCL THROM VAS, V30, P749, DOI 10.1161/ATVBAHA.109.199687
   Louis-Jean S, 2019, J AGR FOOD CHEM, V67, P12675, DOI 10.1021/acs.jafc.9b04879
   Lozupone CA, 2012, NATURE, V489, P220, DOI 10.1038/nature11550
   Luo F, 2019, CARDIOVASC DIABETOL, V18, DOI 10.1186/s12933-019-0860-y
   Lynch SV, 2016, NEW ENGL J MED, V375, P2369, DOI 10.1056/NEJMra1600266
   Ma W, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.01336
   Mandrich L, 2020, NUTRIENTS, V12, DOI 10.3390/nu12030868
   Matson V, 2018, SCIENCE, V359, P104, DOI 10.1126/science.aao3290
   Mazzocchi A, 2019, NUTRIENTS, V11, DOI 10.3390/nu11122941
   O'Sullivan D, 2019, NAT REV IMMUNOL, V19, P324, DOI 10.1038/s41577-019-0140-9
   Oesterle A, 2017, CIRC RES, V120, P229, DOI 10.1161/CIRCRESAHA.116.308537
   Orekhov AN, 2020, CURR NEUROPHARMACOL, V18, P1064, DOI 10.2174/1570159X17666191118125018
   Panyod S, 2020, J AGR FOOD CHEM, V68, P3088, DOI 10.1021/acs.jafc.9b07555
   Patrignani P, 2016, J AM COLL CARDIOL, V68, P967, DOI 10.1016/j.jacc.2016.05.083
   Patrono C, 2019, NAT REV CARDIOL, V16, P675, DOI 10.1038/s41569-019-0225-y
   Picard F, 2004, NATURE, V429, P771, DOI 10.1038/nature02583
   Pollak M, 2017, DIABETOLOGIA, V60, P1662, DOI 10.1007/s00125-017-4352-x
   Poznyak AV, 2020, CELLS-BASEL, V9, DOI 10.3390/cells9030584
   Prizment AE, 2019, CANCER RES, V79, DOI 10.1158/1538-7445.SABCS18-5060
   Puissant A, 2010, CANCER RES, V70, P1042, DOI 10.1158/0008-5472.CAN-09-3537
   Qin JJ, 2010, NATURE, V464, P59, DOI 10.1038/nature08821
   Ramirez-Farias C, 2009, BRIT J NUTR, V101, P541, DOI 10.1017/S0007114508019880
   Rath E, 2018, NAT REV GASTRO HEPAT, V15, P497, DOI 10.1038/s41575-018-0021-x
   Rauf A, 2018, CRIT REV FOOD SCI, V58, P1428, DOI 10.1080/10408398.2016.1263597
   Rena G, 2017, DIABETOLOGIA, V60, P1577, DOI 10.1007/s00125-017-4342-z
   Ridker PM, 2008, NEW ENGL J MED, V359, P2195, DOI 10.1056/NEJMoa0807646
   Rinninella E, 2019, MICROORGANISMS, V7, DOI 10.3390/microorganisms7010014
   Rogers MAM, 2016, CLIN MICROBIOL INFEC, V22, DOI 10.1016/j.cmi.2015.10.003
   Round J.L, 2010, P NATL ACAD SCI USA, V11, P79
   Round JL, 2018, SCI IMMUNOL, V3, DOI 10.1126/sciimmunol.aao1603
   Routy B, 2018, SCIENCE, V359, P91, DOI 10.1126/science.aan3706
   Rouzaud G, 2003, BRIT J NUTR, V90, P395, DOI 10.1079/BJN2003900
   Ruiz-Canela M, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17081265
   Russo GL, 2007, BIOCHEM PHARMACOL, V74, P533, DOI 10.1016/j.bcp.2007.02.014
   Santoru ML, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-10034-5
   Scharping NE, 2017, CANCER IMMUNOL RES, V5, P9, DOI 10.1158/2326-6066.CIR-16-0103
   Schwingshackl L, 2015, NUTRIENTS, V7, P7651, DOI 10.3390/nu7095356
   Segain JP, 2000, GUT, V47, P397, DOI 10.1136/gut.47.3.397
   Shi X., 2019, NUTRIENTS, V11
   Sigthorsson G, 1998, GUT, V43, P506, DOI 10.1136/gut.43.4.506
   Singh AK, 2019, NUTRIENTS, V11, DOI 10.3390/nu11092216
   Singh N, 2014, IMMUNITY, V40, P128, DOI 10.1016/j.immuni.2013.12.007
   Skelly AN, 2019, NAT REV IMMUNOL, V19, P305, DOI 10.1038/s41577-019-0144-5
   So D, 2018, AM J CLIN NUTR, V107, P965, DOI 10.1093/ajcn/nqy041
   Sobenin IA, 2019, CHIN J NAT MEDICINES, V17, P721, DOI [10.1016/S1875-5364(19)30088-3, 10.1016/S1875-5364(19)30089-5]
   Song LX, 2001, ARCH BIOCHEM BIOPHYS, V391, P72, DOI 10.1006/abbi.2001.2402
   Stepankova R, 2010, J ATHEROSCLER THROMB, V17, P796, DOI 10.5551/jat.3285
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Tang WHW, 2019, J AM COLL CARDIOL, V73, P2089, DOI 10.1016/j.jacc.2019.03.024
   Tanoue T, 2019, NATURE, V565, P600, DOI 10.1038/s41586-019-0878-z
   Tlaskalova-Hogenova H, 2011, CELL MOL IMMUNOL, V8, P110, DOI 10.1038/cmi.2010.67
   Turnbaugh PJ, 2009, SCI TRANSL MED, V1, DOI 10.1126/scitranslmed.3000322
   Tuteja S, 2019, CIRC-GENOM PRECIS ME, V12, P421, DOI 10.1161/CIRCGEN.119.002314
   van der Vliet H.J., 2020, J CLIN MED, V9
   van Kessel SP, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-08294-y
   Verdura S, 2019, ONCOIMMUNOLOGY, V8, DOI 10.1080/2162402X.2019.1633235
   Verma R, 2018, SCI IMMUNOL, V3, DOI 10.1126/sciimmunol.aat6975
   Vieira-Silva S, 2020, NATURE, V581, P310, DOI 10.1038/s41586-020-2269-x
   Wallace BD, 2010, SCIENCE, V330, P831, DOI 10.1126/science.1191175
   Wells JM, 2017, AM J PHYSIOL-GASTR L, V312, pG171, DOI 10.1152/ajpgi.00048.2015
   Westfall S, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-25382-z
   Wil DN, 2019, CARDIOVASC DIAGN THE, V9, P545, DOI 10.21037/cdt.2019.12.04
   Wolf AJ, 2018, NAT REV IMMUNOL, V18, P243, DOI 10.1038/nri.2017.136
   Wong SH, 2017, GASTROENTEROLOGY, V153, P1621, DOI 10.1053/j.gastro.2017.08.022
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Wu W., MICROBIOME BMC, DOI [10.21203/rs.3.rs-23528/v1, DOI 10.21203/RS.3.RS-23528/V1]
   Wu WK, 2019, GUT, V68, P1439, DOI 10.1136/gutjnl-2018-317155
   Xiao L, 2017, FOOD CHEM TOXICOL, V105, P22, DOI 10.1016/j.fct.2017.03.048
   Yamakoshi Jun, 2001, Microbial Ecology in Health and Disease, V13, P25, DOI 10.1080/089106001750071672
   Yang YH, 2016, J CELL PHYSIOL, V231, P2570, DOI 10.1002/jcp.25349
   Yarmolinsky J, 2020, JAMA-J AM MED ASSOC, V323, P646, DOI 10.1001/jama.2020.0150
   Yokota A, 2012, GUT MICROBES, V3, P455, DOI 10.4161/gmic.21216
   Yu HN, 2014, ARCH MED RES, V45, P195, DOI 10.1016/j.arcmed.2014.03.008
   Yu H, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00617
   Zheng JP, 2018, CARBOHYD POLYM, V190, P77, DOI 10.1016/j.carbpol.2018.02.058
   Zhou Q, 2009, CURR PHARM DESIGN, V15, P467, DOI 10.2174/138161209787315684
   Zi FM, 2018, ONCOL LETT, V15, P683, DOI 10.3892/ol.2017.7412
   Zimmermann M, 2019, NATURE, V570, P462, DOI 10.1038/s41586-019-1291-3
NR 156
TC 15
Z9 15
U1 1
U2 32
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1044-579X
EI 1096-3650
J9 SEMIN CANCER BIOL
JI Semin. Cancer Biol.
PD MAY
PY 2021
VL 70
BP 85
EP 97
DI 10.1016/j.semcancer.2020.06.017
EA MAR 2021
PG 13
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA QR8IK
UT WOS:000625456700009
PM 32610150
DA 2023-06-08
ER

PT J
AU Pascale, A
   Marchesi, N
   Govoni, S
   Coppola, A
   Gazzaruso, C
AF Pascale, Alessia
   Marchesi, Nicoletta
   Govoni, Stefano
   Coppola, Adriana
   Gazzaruso, Carmine
TI The role of gut microbiota in obesity, diabetes mellitus, and effect of
   metformin: new insights into old diseases
SO CURRENT OPINION IN PHARMACOLOGY
LA English
DT Article
ID BILE-ACIDS; INSULIN; ALTERS; BRAIN; FAT
AB There is a recent growing evidence that abnormalities in the microbiota composition can have a major role in the development of obesity and diabetes and that some actions of metformin may be mediated by gut bacteria. Several mechanisms have been found. A reduced microbial diversity is associated to inflammation, insulin-resistance, and adiposity. In particular, a rise in the Firmicutes/Bacteroidetes ratio is related to a low-grade inflammation and to an increased capability of harvesting energy from food. Interestingly, high-fat-diet favors the growth of bacteria capable of extracting more energy from food. Changes in some metabolites, such as short-chain fatty acids (SCFAs), produced by gut microbiota, and decreased amounts of the Akkermansia muciniphila are associated with the presence of type 2 diabetes. Among the mechanisms by which metformin acts on glucose metabolism and on the cardiovascular risk, some of them are due to positive effects on gut microbiota. A shift toward positive SCFAs produced by bacteria, an increase in some bacterial strains, including A. muciniphila, and some actions on bile acids mediated by microbiota have been described. All these recent advances have been reported and discussed.
C1 [Pascale, Alessia; Marchesi, Nicoletta; Govoni, Stefano] Univ Pavia, Pharmacol Sect, Dept Drug Sci, I-27100 Pavia, Italy.
   [Coppola, Adriana; Gazzaruso, Carmine] Clin Inst Beato Matteo, Diabet & Endocrine & Metab Dis Unit, I-27029 Vigevano, Italy.
   [Coppola, Adriana; Gazzaruso, Carmine] Clin Inst Beato Matteo, Ctr Appl Clin Res CeRCA, I-27029 Vigevano, Italy.
C3 University of Pavia
RP Gazzaruso, C (通讯作者)，Clin Inst Beato Matteo, Diabet & Endocrine & Metab Dis Unit, I-27029 Vigevano, Italy.; Gazzaruso, C (通讯作者)，Clin Inst Beato Matteo, Ctr Appl Clin Res CeRCA, I-27029 Vigevano, Italy.
EM c.gazzaruso@gmail.com
RI Coppola, Adriana/AAA-4259-2022; Marchesi, Nicoletta/GQZ-7428-2022;
   Gazzaruso, Carmine/F-9072-2018
OI Marchesi, Nicoletta/0000-0001-6271-1420; Gazzaruso,
   Carmine/0000-0001-9974-0735; COPPOLA, Adriana/0000-0003-0508-0073
CR Backhed F, 2004, P NATL ACAD SCI USA, V101, P15718, DOI 10.1073/pnas.0407076101
   Bailey CJ, 2008, DIABETOLOGIA, V51, P1552, DOI 10.1007/s00125-008-1053-5
   Campbell JM, 2017, AGEING RES REV, V40, P31, DOI 10.1016/j.arr.2017.08.003
   Canfora EE, 2015, NAT REV ENDOCRINOL, V11, P577, DOI 10.1038/nrendo.2015.128
   Cani PD, 2018, GUT, V67, P1716, DOI 10.1136/gutjnl-2018-316723
   Cani PD, 2019, NAT METAB, V1, P34, DOI 10.1038/s42255-018-0017-4
   CASPARY WF, 1975, DIABETOLOGIA, V11, P113, DOI 10.1007/BF00429833
   Chambers Edward S, 2018, Curr Nutr Rep, V7, P198, DOI 10.1007/s13668-018-0248-8
   Cheng D, 2018, EXP CELL RES, V368, P101, DOI 10.1016/j.yexcr.2018.04.018
   Cornejo-Pareja I, 2019, EUR J CLIN NUTR, V72, P26, DOI 10.1038/s41430-018-0306-8
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   De Vadder F, 2014, CELL, V156, P84, DOI 10.1016/j.cell.2013.12.016
   Ding SZ, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009875
   Grice EA, 2012, ANNU REV GENOM HUM G, V13, P151, DOI 10.1146/annurev-genom-090711-163814
   Hanninen A, 2018, GUT, V67, P1445, DOI 10.1136/gutjnl-2017-314508
   Harsch Igor Alexander, 2018, Med Sci (Basel), V6, DOI 10.3390/medsci6020032
   Kim MH, 2014, J ENDOCRINOL, V220, P117, DOI 10.1530/JOE-13-0381
   Lam YY, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0034233
   Lee H, 2018, GUT MICROBES, V9, P155, DOI 10.1080/19490976.2017.1405209
   Ley RE, 2005, P NATL ACAD SCI USA, V102, P11070, DOI 10.1073/pnas.0504978102
   Matsubara T, 2013, MOL CELL ENDOCRINOL, V368, P17, DOI 10.1016/j.mce.2012.05.004
   Minamii T, 2018, J DIABETES INVEST, V9, P701, DOI 10.1111/jdi.12864
   Nguyen A, 2008, CELL SIGNAL, V20, P2180, DOI 10.1016/j.cellsig.2008.06.014
   Ochoa-Reparaz J, 2016, CURR OBES REP, V5, P51, DOI 10.1007/s13679-016-0191-1
   Pascale A, 2018, ENDOCRINE, V61, P357, DOI 10.1007/s12020-018-1605-5
   Plovier H, 2017, NAT MED, V23, P107, DOI 10.1038/nm.4236
   Prattichizzo F, 2018, AGEING RES REV, V48, P87, DOI 10.1016/j.arr.2018.10.003
   Rodriguez J, 2018, CURR OPIN CLIN NUTR, V21, P294, DOI 10.1097/MCO.0000000000000468
   Shen W, 2014, J NUTR BIOCHEM, V25, P270, DOI 10.1016/j.jnutbio.2013.09.009
   Sonne DP, 2015, DIABETES CARE, V38, P1858, DOI DOI 10.2337/dc15-0658
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Wahlstrom A, 2016, CELL METAB, V24, P41, DOI 10.1016/j.cmet.2016.05.005
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Wu TZ, 2017, EXPERT REV GASTROENT, V11, P157, DOI 10.1080/17474124.2017.1273769
NR 34
TC 131
Z9 135
U1 8
U2 119
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1471-4892
EI 1471-4973
J9 CURR OPIN PHARMACOL
JI Curr. Opin. Pharmacol.
PD DEC
PY 2019
VL 49
BP 1
EP 5
DI 10.1016/j.coph.2019.03.011
PG 5
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA JW5IV
UT WOS:000503086500003
PM 31015106
HC Y
HP N
DA 2023-06-08
ER

PT J
AU Varghese, E
   Samuel, SM
   Liskova, A
   Kubatka, P
   Busselberg, D
AF Varghese, Elizabeth
   Samuel, Samson Mathews
   Liskova, Alena
   Kubatka, Peter
   Busselberg, Dietrich
TI Diabetes and coronavirus (SARS-CoV-2): Molecular mechanism of Metformin
   intervention and the scientific basis of drug repurposing
SO PLOS PATHOGENS
LA English
DT Review
ID FACTOR-KAPPA-B; ADVANCED GLYCATION; ENDOTHELIAL DYSFUNCTION;
   INSULIN-RESISTANCE; COVID-19 SEVERITY; SARS CORONAVIRUS;
   MEMBRANE-FUSION; GUT MICROBIOTA; GLUCOSE-LEVELS; MORTALITY
AB Coronavirus Disease 2019 (COVID-19), caused by a new strain of coronavirus called Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), was declared a pandemic by WHO on March 11, 2020. Soon after its emergence in late December 2019, it was noticed that diabetic individuals were at an increased risk of COVID-19-associated complications, ICU admissions, and mortality. Maintaining proper blood glucose levels using insulin and/or other oral antidiabetic drugs (such as Metformin) reduced the detrimental effects of COVID-19. Interestingly, in diabetic COVID-19 patients, while insulin administration was associated with adverse outcomes, Metformin treatment was correlated with a significant reduction in disease severity and mortality rates among affected individuals. Metformin was extensively studied for its antioxidant, anti-inflammatory, immunomodulatory, and antiviral capabilities that would explain its ability to confer cardiopulmonary and vascular protection in COVID-19. Here, we describe the various possible molecular mechanisms that contribute to Metformin therapy's beneficial effects and lay out the scientific basis of repurposing Metformin for use in COVID-19 patients.
C1 [Varghese, Elizabeth; Samuel, Samson Mathews; Busselberg, Dietrich] Qatar Fdn, Weill Cornell Med Qatar, Dept Physiol & Biophys, Doha, Qatar.
   [Liskova, Alena] Comenius Univ, Jessenius Fac Med, Dept Obstet & Gynecol, Martin, TN, Slovakia.
   [Kubatka, Peter] Comenius Univ, Jessenius Fac Med, Dept Med Biol, Martin, TN, Slovakia.
C3 Qatar Foundation (QF); Weill Cornell Medical College Qatar; Comenius
   University Bratislava; Comenius University Bratislava
RP Samuel, SM; Busselberg, D (通讯作者)，Qatar Fdn, Weill Cornell Med Qatar, Dept Physiol & Biophys, Doha, Qatar.
EM sms2016@qatar-med.cornell.edu; dib2015@qatar-med.cornell.edu
OI Kubatka, Peter/0000-0003-4312-5076; Busselberg,
   Dietrich/0000-0001-5196-3366; Mathews Samuel, Samson/0000-0002-5541-6623
FU Qatar National Research Fund (QNRF, Qatar Foundation)
   [NPRP11S-1214-170101]; Biomedical Research Program (BMRP) at Weill
   Cornell Medicine-Qatar - Qatar Foundation
FX This work was supported by a National Priorities Research Program grant
   (NPRP11S1214-170101; June 2019-Current) awarded to DB, from the Qatar
   National Research Fund (QNRF, a member of Qatar Foundation)
   (https://mis.qgrants.org/Public/AwardDetails.aspx?ParamPid= fghmdaekde).
   The salaries for EV and SMS were paid from the above mentioned QNRF
   funded grant. The publication costs of this article was funded by the
   Biomedical Research Program (BMRP) at Weill Cornell Medicine-Qatar,
   funded by Qatar Foundation. The statements made herein are solely the
   responsibility of the authors. The funders had no role in study design,
   data collection and analysis, decision to publish, or preparation of the
   manuscript.
CR Abu Samaan TM, 2019, BIOMOLECULES, V9, DOI 10.3390/biom9120789
   Abu-Raddad LJ, 2021, NEW ENGL J MED, V385, P187, DOI 10.1056/NEJMc2104974
   Adeshara KA, 2020, DIABETES METAB SYND, V14, P1449, DOI 10.1016/j.dsx.2020.07.036
   Alanagreh L, 2020, PATHOGENS, V9, DOI 10.3390/pathogens9050331
   Allard R, 2010, DIABETES CARE, V33, P1491, DOI 10.2337/dc09-2215
   Amraei R, 2020, CELLS-BASEL, V9, DOI 10.3390/cells9071652
   [Anonymous], 2020, PEDIATR DIABETES, V21, P413, DOI 10.1111/pedi.13013
   Apicella M, 2020, LANCET DIABETES ENDO, V8, P782, DOI 10.1016/S2213-8587(20)30238-2
   Bangi Shifa, 2020, SN Compr Clin Med, V2, P1296, DOI 10.1007/s42399-020-00452-4
   Banu N, 2020, LIFE SCI, V256, DOI 10.1016/j.lfs.2020.117905
   Barron E., 2020, TYPE 1 TYPE 2 DIABET
   Boddu SK, 2020, DIABETES METAB SYND, V14, P2211, DOI 10.1016/j.dsx.2020.11.012
   Bode B, 2020, J DIABETES SCI TECHN, V14, P813, DOI 10.1177/1932296820924469
   Bramante CT, 2021, J MED VIROL, V93, P4273, DOI 10.1002/jmv.26873
   Bramante CT, 2021, LANCET HEALTH LONGEV, V2, pE34, DOI 10.1016/S2666-7568(20)30033-7
   Budden KF, 2017, NAT REV MICROBIOL, V15, P55, DOI 10.1038/nrmicro.2016.142
   Cameron AR, 2016, CIRC RES, V119, P652, DOI 10.1161/CIRCRESAHA.116.308445
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   CDC, 2021, EM SARS COV 2 VAR
   Chen XF, 2016, INT J CLIN EXP MED, V9, P2913
   Chen YC, 2020, DIABETES CARE, V43, P1399, DOI 10.2337/dc20-0660
   Chen YQ, 2020, HYPERTENS RES, V43, P754, DOI 10.1038/s41440-020-0457-6
   Cheng X, 2020, CELL METAB, V32, P537, DOI 10.1016/j.cmet.2020.08.013
   ClinicalTrials.gov, AD STUD DEM EFF SAF
   ClinicalTrials.gov, 2020, MET COVID TRIAL METF
   Codo AC, 2020, CELL METAB, V32, P437, DOI 10.1016/j.cmet.2020.07.007
   Crouse AB, 2021, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.600439
   Cure E, 2020, DIABETES RES CLIN PR, V164, DOI 10.1016/j.diabres.2020.108184
   Curran CS, 2020, FRONT PHARMACOL, V11, DOI 10.3389/fphar.2020.01278
   De Francesco EM, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.00526
   Do JY, 2021, DIABETES METAB, V47, DOI 10.1016/j.diabet.2020.10.006
   Ekeruo IA, 2013, CURR CARDIOVASC RISK, V7, P417, DOI 10.1007/s12170-013-0355-4
   Elbadawi A, 2021, ARTERIOSCL THROM VAS, V41, P545, DOI 10.1161/ATVBAHA.120.315304
   Erener S, 2020, MOL METAB, V39, DOI 10.1016/j.molmet.2020.101044
   Esam Z, 2020, DIABETES RES CLIN PR, V167, DOI 10.1016/j.diabres.2020.108282
   Gao YC, 2020, CTS-CLIN TRANSL SCI, V13, P1055, DOI 10.1111/cts.12897
   Gavriilaki E, 2020, CURR HYPERTENS REP, V22, DOI 10.1007/s11906-020-01078-6
   Gianchandani R, 2020, DIABETES, V69, P2048, DOI 10.2337/dbi20-0022
   Giannarelli R., 2003, Diabetes & Metabolism, V29, p6S28
   Gordon David E, 2020, bioRxiv, DOI 10.1101/2020.03.22.002386
   GOSHUA G, 2020, LANCET HAEMATOL, V7, DOI DOI 10.1016/S2352-3026%2820%2930216-7
   Gregory JM, 2021, DIABETES CARE, V44, P526, DOI 10.2337/dc20-2260
   Guan WJ, 2020, EUR RESPIR J, V55, DOI 10.1183/13993003.00597-2020
   Hamming I, 2004, J PATHOL, V203, P631, DOI 10.1002/path.1570
   Han YC, 2019, CARDIOVASC DIABETOL, V18, DOI 10.1186/s12933-019-0900-7
   Hariyanto Timotius Ivan, 2020, Obes Med, V19, P100290, DOI 10.1016/j.obmed.2020.100290
   Hasan, 2020, PHYSIOL GENOMICS
   Hattori Y, 2006, HYPERTENSION, V47, P1183, DOI 10.1161/01.HYP.0000221429.94591.72
   He L, 2020, BIORXIV, DOI 10.1101/2020.05.11.088500
   Hoffmann M, 2020, CELL, V181, P271, DOI 10.1016/j.cell.2020.02.052
   Hojyo S, 2020, INFLAMM REGEN, V40, DOI 10.1186/s41232-020-00146-3
   Holman N, 2020, LANCET DIABETES ENDO, V8, P823, DOI 10.1016/S2213-8587(20)30271-0
   Hudson BI, 2018, ANNU REV MED, V69, P349, DOI 10.1146/annurev-med-041316-085215
   Huertas A, 2020, EUR RESPIR J, V56, DOI 10.1183/13993003.01634-2020
   Islam N, 2020, O BETA GLCACYLATION
   Isoda K, 2006, ARTERIOSCL THROM VAS, V26, P611, DOI 10.1161/01.ATV.0000201938.78044.75
   JHU, 2021, NTR REFEENCE
   Jiang N, 2021, DIABETES RES CLIN PR, V173, DOI 10.1016/j.diabres.2020.108619
   Jin X, 2015, BIOMED RES INT, V2015, DOI 10.1155/2015/732450
   Jin YF, 2020, SIGNAL TRANSDUCT TAR, V5, DOI 10.1038/s41392-020-00454-7
   Junqueira Caroline, 2021, medRxiv, DOI [10.21203/rs.3.rs-153628/v1, 10.1101/2021.03.06.21252796]
   Khan, 2021, LANCET
   Kim J, 2016, J BIOL CHEM, V291, P18591, DOI 10.1074/jbc.C116.744037
   Kruglikov IL, 2020, ELIFE, V9, DOI 10.7554/eLife.61330
   Kulcsar KA, 2019, JCI INSIGHT, V4, DOI 10.1172/jci.insight.131774
   Kyo M, 2019, RESP RES, V20, DOI 10.1186/s12931-019-1203-y
   Lalau JD, 2021, DIABETES METAB, V47, DOI 10.1016/j.diabet.2020.101216
   Lally MA, 2021, J AM MED DIR ASSOC, V22, P193, DOI 10.1016/j.jamda.2020.10.031
   Lim S, 2021, NAT REV ENDOCRINOL, V17, P11, DOI 10.1038/s41574-020-00435-4
   Lisco G, 2020, ENDOCRINE, V70, P441, DOI 10.1007/s12020-020-02444-9
   Liskova A, 2021, BIOMED PHARMACOTHER, V138, DOI 10.1016/j.biopha.2021.111430
   Liu X, 2020, THERANOSTICS, V10, P7821, DOI 10.7150/thno.47987
   Lukito AA, 2020, DIABETES METAB SYND, V14, P2177, DOI 10.1016/j.dsx.2020.11.006
   Malhotra A, 2020, ISCIENCE, V23, DOI 10.1016/j.isci.2020.101425
   Menendez JA, 2020, AGING-US, V12, P8760, DOI 10.18632/aging.103347
   Millet JK, 2018, VIROLOGY, V517, P3, DOI 10.1016/j.virol.2017.12.015
   Muller JA, 2021, NAT METAB, V3, P149, DOI 10.1038/s42255-021-00347-1
   Niu MJ, 2008, ENDOCRINE, V34, P56, DOI 10.1007/s12020-008-9110-x
   Pinto LC, 2020, ARCH ENDOCRIN METAB, V64, P199, DOI 10.20945/2359-3997000000256
   Polack FP, 2020, NEW ENGL J MED, V383, P2603, DOI 10.1056/NEJMoa2034577
   Pollak M, 2017, DIABETOLOGIA, V60, P1662, DOI 10.1007/s00125-017-4352-x
   Sun Q, 2014, WORLD J DIABETES, V5, P89, DOI 10.4239/wjd.v5.i2.89
   Ribeiro AT, 2020, ANN FOREST SCI, V77, DOI 10.1007/s13595-019-0909-9
   Rockx B, 2020, SCIENCE, V368, P1012, DOI 10.1126/science.abb7314
   Roncon L, 2020, J CLIN VIROL, V127, DOI 10.1016/j.jcv.2020.104354
   Saenwongsa W, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-60213-0
   Salem ESB, 2014, AM J PHYSIOL-RENAL, V306, pF629, DOI 10.1152/ajprenal.00516.2013
   Samuel S. Mathews, 2019, CANCERS BASEL, V11
   Samuel SM, 2021, TRENDS MICROBIOL, V29, P894, DOI 10.1016/j.tim.2021.03.004
   Samuel SM, 2019, BIOMOLECULES, V9, DOI 10.3390/biom9120846
   Samuel SM, 2017, BIOCHEM PHARMACOL, V132, P118, DOI 10.1016/j.bcp.2017.03.001
   Sardu C, 2020, DIABETES CARE, V43, P1408, DOI 10.2337/dc20-0723
   Scheen AJ, 2020, DIABETES METAB, V46, P423, DOI 10.1016/j.diabet.2020.07.006
   Schuiveling M, 2018, CURR DRUG TARGETS, V19, P945, DOI 10.2174/1389450118666170613081730
   Sharma S, 2020, DIABETES RES CLIN PR, V164, DOI 10.1016/j.diabres.2020.108183
   Shoemaker R, 2015, AM J PHYSIOL-ENDOC M, V309, pE621, DOI 10.1152/ajpendo.00054.2015
   Singh AK, 2020, DIABETES RES CLIN PR, V165, DOI 10.1016/j.diabres.2020.108268
   Singh AK, 2020, DIABETES RES CLIN PR, V165, DOI 10.1016/j.diabres.2020.108266
   Soberanes S, 2019, CELL METAB, V29, P335, DOI [10.1016/j.cmet.2018.09.019, 10.1016/j.cmet.2018.12.001]
   Santos RAS, 2018, PHYSIOL REV, V98, P505, DOI 10.1152/physrev.00023.2016
   Takeda M, 2013, DIABETES, V62, P223, DOI 10.2337/db12-0177
   Tan KCB, 2002, DIABETES CARE, V25, P1055, DOI 10.2337/diacare.25.6.1055
   Tang N, 2020, J THROMB HAEMOST, V18, P844, DOI 10.1111/jth.14768
   Tang T, 2020, ANTIVIR RES, V178, DOI 10.1016/j.antiviral.2020.104792
   Teuwen LA, 2020, NAT REV IMMUNOL, V20, P389, DOI 10.1038/s41577-020-0343-0
   Thaiss CA, 2018, SCIENCE, V359, P1376, DOI 10.1126/science.aar3318
   Triggle CR, 2017, ACTA PHYSIOL, V219, P138, DOI 10.1111/apha.12644
   Tsai S, 2018, CELL METAB, V28, P922, DOI 10.1016/j.cmet.2018.08.003
   Unsworth R, 2020, DIABETES CARE, V43, pE170, DOI 10.2337/dc20-1551
   Ursini F, 2020, DIABETES RES CLIN PR, V164, DOI 10.1016/j.diabres.2020.108167
   van Zoelen MA, 2011, CRIT CARE, V15, DOI 10.1186/cc9990
   Varga Z, 2020, LANCET, V395, pe100, DOI 10.1016/S0140-6736(20)30937-5
   Varghese S, 2019, BIOMOLECULES, V9, DOI 10.3390/biom9010016
   de Oliveira GLV, 2021, FRONT IMMUNOL, V12, DOI 10.3389/fimmu.2021.635471
   Voysey M, 2021, LANCET, V397, P99, DOI 10.1016/S0140-6736(20)32661-1
   Wang HL, 2008, CELL RES, V18, P290, DOI 10.1038/cr.2008.15
   Wang SF, 2020, DIABETOLOGIA, V63, P2102, DOI 10.1007/s00125-020-05209-1
   Wedrowska E, 2020, ANN AGR ENV MED, V27, P175, DOI 10.26444/aaem/122079
   Wiernsperger N F, 2000, Diabetes Technol Ther, V2, P259, DOI 10.1089/15209150050025230
   World Health Organization, TIM WHOS RESP COVID
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Xin G, 2016, SCI REP-UK, V6, DOI 10.1038/srep36222
   Yan YL, 2020, BMJ OPEN DIAB RES CA, V8, DOI 10.1136/bmjdrc-2020-001343
   Yang JK, 2006, DIABETIC MED, V23, P623, DOI 10.1111/j.1464-5491.2006.01861.x
   Yang LL, 2020, CELL STEM CELL, V27, P125, DOI 10.1016/j.stem.2020.06.015
   Yeoh YK, 2021, GUT, V70, P698, DOI 10.1136/gutjnl-2020-323020
   Zhang J, 2018, AM J RESP CRIT CARE, V198, P509, DOI 10.1164/rccm.201712-2570OC
   Zheng M, 2021, J DIABETES RES, DOI 10.1155/2021/9526701
   Zhou ZE, 2016, J DIABETES RES, V2016, DOI 10.1155/2016/4847812
   Zhu L, 2020, CARDIORENAL MED, V10, P470, DOI 10.1159/000510916
   Zhu ZX, 2020, RESP RES, V21, DOI 10.1186/s12931-020-01479-w
   Zimmet P, 1999, DRUGS, V58, P21, DOI 10.2165/00003495-199958001-00007
NR 132
TC 23
Z9 23
U1 2
U2 7
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1553-7366
EI 1553-7374
J9 PLOS PATHOG
JI PLoS Pathog.
PD JUN
PY 2021
VL 17
IS 6
AR e1009634
DI 10.1371/journal.ppat.1009634
PG 20
WC Microbiology; Parasitology; Virology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology; Parasitology; Virology
GA SW1UY
UT WOS:000664307300001
PM 34157054
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Bauer, PV
   Duca, FA
AF Bauer, Paige V.
   Duca, Frank A.
TI Targeting the gastrointestinal tract to treat type 2 diabetes
SO JOURNAL OF ENDOCRINOLOGY
LA English
DT Review
DE gut; metformin; gut sensing; gut microbiota; bile acids
ID GLUCAGON-LIKE PEPTIDE-1; Y GASTRIC BYPASS; DUODENAL-JEJUNAL BYPASS;
   FARNESOID-X-RECEPTOR; VERTICAL SLEEVE GASTRECTOMY; PROTEIN-COUPLED
   RECEPTOR; GROWTH-FACTOR 19; OLIGOFRUCTOSE PROMOTES SATIETY; LOWERS
   GLUCOSE-PRODUCTION; HUMAN GUT MICROBIOTA
AB The rising global rates of type 2 diabetes and obesity present a significant economic and social burden, underscoring the importance for effective and safe therapeutic options. The success of glucagon-like-peptide-1 receptor agonists in the treatment of type 2 diabetes, along with the potent glucose-lowering effects of bariatric surgery, highlight the gastrointestinal tract as a potential target for diabetes treatment. Furthermore, recent evidence suggests that the gut plays a prominent role in the ability of metformin to lower glucose levels. As such, the current review highlights some of the current and potential pathways in the gut that could be targeted to improve glucose homeostasis, such as changes in nutrient sensing, gut peptides, gut microbiota and bile acids. A better understanding of these pathways will lay the groundwork for novel gut-targeted antidiabetic therapies, some of which have already shown initial promise.
C1 [Bauer, Paige V.; Duca, Frank A.] Toronto Gen Hosp, Res Inst, Toronto, ON, Canada.
   [Bauer, Paige V.; Duca, Frank A.] UHN, Dept Med, Toronto, ON, Canada.
   [Bauer, Paige V.] Univ Toronto, Dept Physiol, Toronto, ON, Canada.
C3 University of Toronto; University Health Network Toronto; Toronto
   General Hospital; University of Toronto; University Health Network
   Toronto; University of Toronto
RP Duca, FA (通讯作者)，Toronto Gen Hosp, Res Inst, Toronto, ON, Canada.; Duca, FA (通讯作者)，UHN, Dept Med, Toronto, ON, Canada.
EM frank.duca@uhnres.utoronto.ca
FU Ontario Graduate Scholarship; Banting and Best Diabetes Centre graduate
   studentship
FX P V B is supported by an Ontario Graduate Scholarship and a Banting and
   Best Diabetes Centre graduate studentship. F A D is a Banting Fellow.
CR Rojas LBA, 2013, DIABETOL METAB SYNDR, V5, DOI 10.1186/1758-5996-5-6
   Anhe FF, 2015, GUT, V64, P872, DOI 10.1136/gutjnl-2014-307142
   Archer BJ, 2004, BRIT J NUTR, V91, P591, DOI 10.1079/BJN20031088
   Bauer PV, 2016, CELL MOL LIFE SCI, V73, P737, DOI 10.1007/s00018-015-2083-z
   Bayham BE, 2012, DIABETES TECHNOL THE, V14, P30, DOI 10.1089/dia.2011.0151
   Bhat VK, 2013, DIABETOLOGIA, V56, P1417, DOI 10.1007/s00125-013-2892-2
   Bhat VK, 2013, BIOCHEM PHARMACOL, V85, P1655, DOI 10.1016/j.bcp.2013.03.009
   Bhutta HY, 2014, AM J PHYSIOL-GASTR L, V307, pG588, DOI 10.1152/ajpgi.00405.2013
   Blevins T, 2011, J CLIN ENDOCR METAB, V96, P1301, DOI 10.1210/jc.2010-2081
   Breen DM, 2012, NAT MED, V18, P950, DOI 10.1038/nm.2745
   Breen DM, 2011, DIABETES, V60, P3148, DOI 10.2337/db11-0852
   Briscoe CP, 2003, J BIOL CHEM, V278, P11303, DOI 10.1074/jbc.M211495200
   Buchwald H., 2004, JAMA (Journal of the American Medical Association), V292, P1724, DOI 10.1001/jama.292.14.1724
   Buchwald H, 2009, AM J MED, V122, P248, DOI 10.1016/j.amjmed.2008.09.041
   Burcelin R, 2001, DIABETES, V50, P1720, DOI 10.2337/diabetes.50.8.1720
   Buse JB, 2004, DIABETES CARE, V27, P2628, DOI 10.2337/diacare.27.11.2628
   Buse JB, 2016, DIABETES CARE, V39, P198, DOI 10.2337/dc15-0488
   Buse JB, 2009, LANCET, V374, P39, DOI 10.1016/S0140-6736(09)60659-0
   Cani PD, 2009, AM J CLIN NUTR, V90, P1236, DOI 10.3945/ajcn.2009.28095
   Cani PD, 2006, DIABETES, V55, P1484, DOI 10.2337/db05-1360
   Cani PD, 2004, BRIT J NUTR, V92, P521, DOI 10.1079/BJN20041225
   Cani PD, 2006, EUR J CLIN NUTR, V60, P567, DOI 10.1038/sj.ejcn.1602350
   Cani PD, 2005, OBES RES, V13, P1000, DOI 10.1038/oby.2005.117
   Chambers AP, 2013, GASTROENTEROLOGY, V144, P50, DOI 10.1053/j.gastro.2012.09.009
   Chambers AP, 2011, GASTROENTEROLOGY, V141, P950, DOI 10.1053/j.gastro.2011.05.050
   Chambers ES, 2015, GUT, V64, P1744, DOI 10.1136/gutjnl-2014-307913
   Chandarana K, 2013, MOL METAB, V2, P142, DOI 10.1016/j.molmet.2013.03.001
   Chandarana K, 2011, DIABETES, V60, P810, DOI 10.2337/db10-0566
   Chen ZY, 2014, J CLIN INVEST, V124, P3391, DOI 10.1172/JCI72517
   Cheung GWC, 2009, CELL METAB, V10, P99, DOI 10.1016/j.cmet.2009.07.005
   Christensen LW, 2015, PHYSIOL REP, V3, DOI 10.14814/phy2.12551
   Clara R, 2016, METABOLISM, V65, P8, DOI 10.1016/j.metabol.2015.10.003
   Clements RH, 2004, AM SURGEON, V70, P1
   Cohen RV, 2007, SURG OBES RELAT DIS, V3, P195, DOI 10.1016/j.soard.2007.01.009
   Cohen Ricardo V, 2012, Surg Obes Relat Dis, V8, pe66, DOI 10.1016/j.soard.2011.07.007
   Cote CD, 2015, NAT MED, V21, P498, DOI 10.1038/nm.3821
   Cote CD, 2014, J BIOL CHEM, V289, P11642, DOI 10.1074/jbc.O114.556068
   Daniele G, 2015, DIABETES, V64, P3406, DOI 10.2337/db14-1718
   Dao MC, 2016, GUT, V65, P426, DOI 10.1136/gutjnl-2014-308778
   Dar MS, 2012, OBES SURG, V22, P1077, DOI 10.1007/s11695-012-0624-1
   Darcel NP, 2005, J NUTR, V135, P1491, DOI 10.1093/jn/135.6.1491
   Day JW, 2012, BIOPOLYMERS, V98, P443, DOI 10.1002/bip.22072
   Day JW, 2009, NAT CHEM BIOL, V5, P749, DOI 10.1038/nchembio.209
   de Lartigue G, 2014, MOL METAB, V3, P595, DOI 10.1016/j.molmet.2014.06.003
   Deacon CF, 2016, DIABETES OBES METAB, V18, P333, DOI 10.1111/dom.12610
   DeFronzo RA, 2005, DIABETES CARE, V28, P1092, DOI 10.2337/diacare.28.5.1092
   Derrien M, 2004, INT J SYST EVOL MICR, V54, P1469, DOI 10.1099/ijs.0.02873-0
   Drucker DJ, 2008, LANCET, V372, P1240, DOI 10.1016/S0140-6736(08)61206-4
   Duca FA, 2014, DIABETES OBES METAB, V16, P68, DOI 10.1111/dom.12340
   Duca FA, 2015, NAT MED, V21, P506, DOI 10.1038/nm.3787
   Edfalk S, 2008, DIABETES, V57, P2280, DOI 10.2337/db08-0307
   Egerod KL, 2012, ENDOCRINOLOGY, V153, P5782, DOI 10.1210/en.2012-1595
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Everard A, 2011, DIABETES, V60, P2775, DOI 10.2337/db11-0227
   Fang S, 2015, NAT MED, V21, P159, DOI 10.1038/nm.3760
   Finan B, 2015, NAT MED, V21, P27, DOI 10.1038/nm.3761
   Finan B, 2013, SCI TRANSL MED, V5, DOI 10.1126/scitranslmed.3007218
   Fiorucci S, 2009, TRENDS PHARMACOL SCI, V30, P570, DOI 10.1016/j.tips.2009.08.001
   Foretz M, 2014, CELL METAB, V20, P953, DOI 10.1016/j.cmet.2014.09.018
   Foretz M, 2010, J CLIN INVEST, V120, P2355, DOI 10.1172/JCI40671
   Fosgerau K, 2013, DIABETES OBES METAB, V15, P62, DOI 10.1111/j.1463-1326.2012.01676.x
   Furet JP, 2010, DIABETES, V59, P3049, DOI 10.2337/db10-0253
   Furman BL, 2012, TOXICON, V59, P464, DOI 10.1016/j.toxicon.2010.12.016
   Gagner M, 2011, SURG ENDOSC, V25, P655, DOI 10.1007/s00464-010-1221-9
   Garber A, 2009, LANCET, V373, P473, DOI 10.1016/S0140-6736(08)61246-5
   Geloneze B, 2012, ANN SURG, V256, P72, DOI 10.1097/SLA.0b013e3182592c62
   Gerhard GS, 2013, DIABETES CARE, V36, P1859, DOI 10.2337/dc12-2255
   Gissey LC, 2016, CURR ATHEROSCLER REP, V18, DOI 10.1007/s11883-016-0590-5
   Gribble FM, 2003, DIABETES, V52, P1147, DOI 10.2337/diabetes.52.5.1147
   Grueneberger JM, 2014, SURGERY, V155, P165, DOI 10.1016/j.surg.2013.05.033
   Grueneberger JM, 2013, VIDEOSURGERY MINIINV, V8, P130, DOI 10.5114/wiitm.2011.32925
   Grunddal KV, 2016, ENDOCRINOLOGY, V157, P176, DOI 10.1210/en.2015-1600
   Gustavson SM, 2008, AM J PHYSIOL-ENDOC M, V294, pE506, DOI 10.1152/ajpendo.00589.2007
   Habegger KM, 2014, GUT, V63, P1238, DOI 10.1136/gutjnl-2013-304583
   Habib AM, 2012, ENDOCRINOLOGY, V153, P3054, DOI 10.1210/en.2011-2170
   Handelsman Y, 2015, ENDOCR PRACT, V21, P1, DOI [10.4158/EP15672.GL, 10.4158/EP15672.GLSUPPL]
   Hansen CHF, 2012, DIABETOLOGIA, V55, P2285, DOI 10.1007/s00125-012-2564-7
   Hansen HS, 2012, TRENDS PHARMACOL SCI, V33, P374, DOI 10.1016/j.tips.2012.03.014
   Hansotia T, 2004, DIABETES, V53, P1326, DOI 10.2337/diabetes.53.5.1326
   Harmel E, 2014, ENDOCRINOLOGY, V155, P873, DOI 10.1210/en.2013-1750
   Hauge M, 2015, MOL METAB, V4, P3, DOI 10.1016/j.molmet.2014.10.002
   Heine RJ, 2005, ANN INTERN MED, V143, P559, DOI 10.7326/0003-4819-143-8-200510180-00006
   Heppner KM, 2015, ENDOCRINOLOGY, V156, P255, DOI 10.1210/en.2014-1675
   Hirasawa A, 2005, NAT MED, V11, P90, DOI 10.1038/nm1168
   Holst JJ, 2005, DIABETOLOGIA, V48, P612, DOI 10.1007/s00125-005-1705-7
   Howarth NC, 2003, J NUTR, V133, P3141, DOI 10.1093/jn/133.10.3141
   Iakoubov R, 2007, ENDOCRINOLOGY, V148, P1089, DOI 10.1210/en.2006-1403
   Imoto H, 2014, SURG TODAY, V44, P340, DOI 10.1007/s00595-013-0638-x
   Irwin N, 2013, DIABETES OBES METAB, V15, P650, DOI 10.1111/dom.12079
   Irwin N, 2009, DIABETOLOGIA, V52, P1724, DOI 10.1007/s00125-009-1422-8
   Irwin N, 2015, DIABETES, V64, P2996, DOI 10.2337/db15-0220
   Jacobsen SH, 2012, OBES SURG, V22, P1084, DOI 10.1007/s11695-012-0621-4
   Jang HJ, 2007, P NATL ACAD SCI USA, V104, P15069, DOI 10.1073/pnas.0706890104
   Ji LN, 2013, J DIABETES INVEST, V4, P53, DOI 10.1111/j.2040-1124.2012.00238.x
   Jiang CT, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms10166
   Jimenez A, 2013, DIABETES CARE, V36, P2062, DOI 10.2337/dc12-1535
   Jinnouchi H, 2015, J DIABETES RES, V2015, DOI 10.1155/2015/706416
   Jorgensen NB, 2015, J CLIN ENDOCR METAB, V100, pE396, DOI 10.1210/jc.2014-1658
   Kanoski SE, 2011, ENDOCRINOLOGY, V152, P3103, DOI 10.1210/en.2011-0174
   Kapitza C, 2013, DIABETES OBES METAB, V15, P642, DOI 10.1111/dom.12076
   Karlsson J, 2007, INT J OBESITY, V31, P1248, DOI 10.1038/sj.ijo.0803573
   Kasama K, 2009, OBES SURG, V19, P1341, DOI 10.1007/s11695-009-9873-z
   Kastin AJ, 2003, INT J OBESITY, V27, P313, DOI 10.1038/sj.ijo.0802206
   Katsuma S, 2005, BIOCHEM BIOPH RES CO, V329, P386, DOI 10.1016/j.bbrc.2005.01.139
   Kendall DM, 2005, DIABETES CARE, V28, P1083, DOI 10.2337/diacare.28.5.1083
   Knauf C, 2005, J CLIN INVEST, V115, P3554, DOI 10.1172/JCI25764
   Kokorovic A, 2011, GASTROENTEROLOGY, V141, P1720, DOI 10.1053/j.gastro.2011.06.042
   KREYMANN B, 1987, LANCET, V2, P1300
   Kuhre RE, 2015, DIABETES, V64, P370, DOI 10.2337/db14-0807
   Labouesse MA, 2012, J NEUROENDOCRINOL, V24, P1505, DOI 10.1111/j.1365-2826.2012.02364.x
   Lamont BJ, 2012, J CLIN INVEST, V122, P388, DOI 10.1172/JCI42497
   Le Barz M, 2015, DIABETES METAB J, V39, P291, DOI 10.4093/dmj.2015.39.4.291
   le Roux CW, 2007, ANN SURG, V246, P780, DOI 10.1097/SLA.0b013e3180caa3e3
   le Roux CW, 2006, ANN SURG, V243, P108, DOI 10.1097/01.sla.0000183349.16877.84
   Lee HC, 2010, OBES SURG, V20, P1530, DOI 10.1007/s11695-010-0248-2
   Lee WJ, 2014, OBES SURG, V24, P109, DOI 10.1007/s11695-013-1067-z
   Li F, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms3384
   Li JV, 2011, GUT, V60, P1214, DOI 10.1136/gut.2010.234708
   Li Y, 2011, AM J PHYSIOL-GASTR L, V300, pG217, DOI 10.1152/ajpgi.00356.2010
   Lien F, 2014, J CLIN INVEST, V124, P1037, DOI 10.1172/JCI68815
   Lin HP, 2012, PLOS ONE, V7, DOI [10.1371/journal.pone.0031286, 10.1371/journal.pone.0035240]
   Liou AP, 2013, SCI TRANSL MED, V5, DOI 10.1126/scitranslmed.3005687
   Liou AP, 2011, AM J PHYSIOL-GASTR L, V300, pG895, DOI 10.1152/ajpgi.00521.2010
   Liou AP, 2011, AM J PHYSIOL-GASTR L, V300, pG538, DOI 10.1152/ajpgi.00342.2010
   Liou AP, 2011, GASTROENTEROLOGY, V140, P903, DOI 10.1053/j.gastro.2010.10.012
   Little TJ, 2006, AM J PHYSIOL-ENDOC M, V291, pE647, DOI 10.1152/ajpendo.00099.2006
   Liu SZ, 2012, ANN SURG, V256, P1049, DOI 10.1097/SLA.0b013e31826c3866
   Lockie SH, 2012, DIABETES, V61, P2753, DOI 10.2337/db11-1556
   Lovshin JA, 2009, NAT REV ENDOCRINOL, V5, P262, DOI 10.1038/nrendo.2009.48
   Ma K, 2006, J CLIN INVEST, V116, P1102, DOI 10.1172/JCI25604
   Ma YJ, 2013, PHARM RES-DORDR, V30, P1447, DOI 10.1007/s11095-013-0986-7
   Madiraju AK, 2014, NATURE, V510, P542, DOI 10.1038/nature13270
   Madsbad S, 2016, DIABETES OBES METAB, V18, P317, DOI 10.1111/dom.12596
   Madsbad S, 2014, LANCET DIABETES ENDO, V2, P152, DOI 10.1016/S2213-8587(13)70218-3
   Marceau P, 2015, OBES SURG, V25, P1584, DOI 10.1007/s11695-015-1599-5
   Marcelin G, 2014, MOL METAB, V3, P19, DOI 10.1016/j.molmet.2013.10.002
   Marina AL, 2012, DIABETES CARE, V35, P1119, DOI 10.2337/dc11-2050
   Marre M, 2009, DIABETIC MED, V26, P268, DOI 10.1111/j.1464-5491.2009.02666.x
   McGavigan AK, 2015, GUT, DOI [DOI 10.1136/GUTJNL-2015-309871, 10.1136/gutjn1-2015-309871]
   Meier JJ, 2015, DIABETES CARE, V38, P1263, DOI 10.2337/dc14-1984
   Miller RA, 2013, NATURE, V494, P256, DOI 10.1038/nature11808
   Mingrone G, 2015, LANCET, V386, P964, DOI 10.1016/S0140-6736(15)00075-6
   Mingrone G, 2012, NEW ENGL J MED, V366, P1577, DOI 10.1056/NEJMoa1200111
   MOJSOV S, 1987, J CLIN INVEST, V79, P616, DOI 10.1172/JCI112855
   Mokadem M, 2014, MOL METAB, V3, P191, DOI 10.1016/j.molmet.2013.11.010
   Morinigo R, 2008, ANN SURG, V247, P270, DOI 10.1097/SLA.0b013e31815f6e77
   Morton GJ, 2013, J CLIN INVEST, V123, P4799, DOI 10.1172/JCI70710
   Mudaliar S, 2013, GASTROENTEROLOGY, V145, P574, DOI 10.1053/j.gastro.2013.05.042
   Mumphrey MB, 2013, NEUROGASTROENT MOTIL, V25, pE70, DOI 10.1111/nmo.12034
   Napolitano A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100778
   Nauck M, 2009, DIABETES CARE, V32, P84, DOI 10.2337/dc08-1355
   Nemoz-Gaillard E, 1998, ENDOCRINOLOGY, V139, P932, DOI 10.1210/en.139.3.932
   Neyrinck AM, 2012, NUTR DIABETES, V2, DOI 10.1038/nutd.2011.24
   Osto M, 2013, PHYSIOL BEHAV, V119, P92, DOI 10.1016/j.physbeh.2013.06.008
   Overton HA, 2006, CELL METAB, V3, P167, DOI 10.1016/j.cmet.2006.02.004
   Owen MR, 2000, BIOCHEM J, V348, P607, DOI 10.1042/0264-6021:3480607
   Pan CQ, 2006, J BIOL CHEM, V281, P12506, DOI 10.1074/jbc.M600127200
   Parker HE, 2009, DIABETOLOGIA, V52, P289, DOI 10.1007/s00125-008-1202-x
   Parnell JA, 2009, AM J CLIN NUTR, V89, P1751, DOI 10.3945/ajcn.2009.27465
   Patel RT, 2014, OBESITY, V22, P159, DOI 10.1002/oby.20441
   Pocai A, 2009, DIABETES, V58, P2258, DOI 10.2337/db09-0278
   Poreba MA, 2012, AM J PHYSIOL-ENDOC M, V303, pE899, DOI 10.1152/ajpendo.00116.2012
   Pournaras DJ, 2012, ENDOCRINOLOGY, V153, P3613, DOI 10.1210/en.2011-2145
   Psichas A, 2015, INT J OBESITY, V39, P424, DOI 10.1038/ijo.2014.153
   Psichas A, 2015, J CLIN INVEST, V125, P908, DOI 10.1172/JCI76309
   Pyke C, 2014, ENDOCRINOLOGY, V155, P1280, DOI 10.1210/en.2013-1934
   Ramzy AR, 2014, INT J OBESITY, V38, P379, DOI 10.1038/ijo.2013.201
   Rasmussen BA, 2014, CELL METAB, V19, P155, DOI 10.1016/j.cmet.2013.11.014
   Rasmussen BA, 2012, GASTROENTEROLOGY, V142, P834, DOI 10.1053/j.gastro.2011.12.053
   Ravussin E, 2009, OBESITY, V17, P1736, DOI 10.1038/oby.2009.184
   RAYBOULD HE, 1988, J NEUROSCI, V8, P3018
   Reimann F, 2008, CELL METAB, V8, P532, DOI 10.1016/j.cmet.2008.11.002
   Rhee NA, 2015, DIABETOLOGIA, V58, P2254, DOI 10.1007/s00125-015-3696-3
   Richards P, 2014, DIABETES, V63, P1224, DOI 10.2337/db13-1440
   Rodieux F, 2008, OBESITY, V16, P298, DOI 10.1038/oby.2007.83
   Roopchand DE, 2015, DIABETES, V64, P2847, DOI 10.2337/db14-1916
   Rubino F, 2004, ANN SURG, V240, P236, DOI 10.1097/01.sla.0000133117.12646.48
   Russell-Jones D, 2009, DIABETOLOGIA, V52, P2046, DOI 10.1007/s00125-009-1472-y
   Ryan KK, 2014, NATURE, V509, P183, DOI 10.1038/nature13135
   Ryan KK, 2013, ENDOCRINOLOGY, V154, P9, DOI 10.1210/en.2012-1891
   Sachdev S, 2016, OBES SURG, V26, P957, DOI 10.1007/s11695-015-1834-0
   Sadry SA, 2013, NAT REV ENDOCRINOL, V9, P425, DOI 10.1038/nrendo.2013.47
   Salehi M, 2011, DIABETES, V60, P2308, DOI 10.2337/db11-0203
   Salinari S, 2014, DIABETES, V63, P1069, DOI 10.2337/db13-0856
   Schlogl H, 2013, DIABETES CARE, V36, P1933, DOI 10.2337/dc12-1925
   Schneeberger M, 2015, SCI REP-UK, V5, DOI 10.1038/srep16643
   Schwartz GJ, 2011, PHYSIOL BEHAV, V104, P621, DOI 10.1016/j.physbeh.2011.05.003
   SCOPINARO N, 1979, BRIT J SURG, V66, P618, DOI 10.1002/bjs.1800660906
   Scully Tony, 2012, Nature, V485, pS2
   Secher A, 2014, J CLIN INVEST, V124, P4473, DOI 10.1172/JCI75276
   Seeley RJ, 2015, CELL METAB, V21, P369, DOI 10.1016/j.cmet.2015.01.001
   Seeley RJ, 2000, J NEUROSCI, V20, P1616
   Shah M, 2014, DIABETES, V63, P483, DOI 10.2337/db13-0954
   Shaw RJ, 2005, SCIENCE, V310, P1642, DOI 10.1126/science.1120781
   SHIMIZU I, 1987, ENDOCRINOLOGY, V121, P1076, DOI 10.1210/endo-121-3-1076
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Sinclair EM, 2005, PHYSIOLOGY, V20, P357, DOI 10.1152/physiol.00030.2005
   Sisley S, 2014, J CLIN INVEST, V124, P2456, DOI 10.1172/JCI72434
   Smith EP, 2014, CELL METAB, V19, P1050, DOI 10.1016/j.cmet.2014.04.005
   Stenman LK, 2016, BENEF MICROBES, V7, P11, DOI 10.3920/BM2015.0069
   Stenman LK, 2015, DIABETOL METAB SYNDR, V7, DOI 10.1186/s13098-015-0075-7
   Stepensky D, 2002, DRUG METAB DISPOS, V30, P861, DOI 10.1124/dmd.30.8.861
   Sundaresan S, 2013, FASEB J, V27, P1191, DOI 10.1096/fj.12-217703
   Svendsen B, 2015, ENDOCRINOLOGY, V156, P847, DOI 10.1210/en.2014-1710
   TangChristensen M, 1996, AM J PHYSIOL-REG I, V271, pR848, DOI 10.1152/ajpregu.1996.271.4.R848
   Theodorakis MJ, 2006, AM J PHYSIOL-ENDOC M, V290, pE550, DOI 10.1152/ajpendo.00326.2004
   Thomas C, 2008, NAT REV DRUG DISCOV, V7, P678, DOI 10.1038/nrd2619
   Thomas C, 2009, CELL METAB, V10, P167, DOI 10.1016/j.cmet.2009.08.001
   Tilg H, 2014, GUT, V63, P1513, DOI 10.1136/gutjnl-2014-306928
   Tolhurst G, 2012, DIABETES, V61, P364, DOI 10.2337/db11-1019
   Trabelsi MS, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms8629
   Tremaroli V, 2015, CELL METAB, V22, P228, DOI 10.1016/j.cmet.2015.07.009
   Trevaskis JL, 2015, DIABETES OBES METAB, V17, P61, DOI 10.1111/dom.12390
   Trujillo JM, 2014, ANN PHARMACOTHER, V48, P1494, DOI 10.1177/1060028014545807
   Vahl TP, 2007, ENDOCRINOLOGY, V148, P4965, DOI 10.1210/en.2006-0153
   Vrieze A, 2012, GASTROENTEROLOGY, V143, P913, DOI 10.1053/j.gastro.2012.06.031
   Waget A, 2011, ENDOCRINOLOGY, V152, P3018, DOI 10.1210/en.2011-0286
   Wang PYT, 2008, NATURE, V452, P1012, DOI 10.1038/nature06852
   Wang TT, 2008, ANN SURG, V247, P968, DOI 10.1097/SLA.0b013e318172504d
   Ward M, 2009, GASTROINTEST ENDOSC, V70, P985, DOI 10.1016/j.gie.2009.09.001
   Wilson-Perez HE, 2013, DIABETES, V62, P2380, DOI 10.2337/db12-1498
   Xiao CT, 2015, DIABETES, V64, P2939, DOI 10.2337/db15-0148
   Yamamoto H, 2003, J NEUROSCI, V23, P2939
   Yang PJ, 2016, OBES SURG, V26, P1576, DOI 10.1007/s11695-015-1968-0
   Zadeh-Tahmasebi M, 2016, J BIOL CHEM, V291, P8816, DOI 10.1074/jbc.M116.718460
   Zhang GY, 2011, CAN J SURG, V54, P243, DOI 10.1503/cjs.044209
   Zhang HS, 2009, P NATL ACAD SCI USA, V106, P2365, DOI 10.1073/pnas.0812600106
   Zhang JH, 2013, AM J PHYSIOL-GASTR L, V304, pG940, DOI 10.1152/ajpgi.00398.2012
NR 228
TC 16
Z9 17
U1 0
U2 31
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA STARLING HOUSE, 1600 BRISTOL PARKWAY N, BRISTOL, ENGLAND
SN 0022-0795
EI 1479-6805
J9 J ENDOCRINOL
JI J. Endocrinol.
PD SEP
PY 2016
VL 230
IS 3
BP R95
EP R113
DI 10.1530/JOE-16-0056
PG 19
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DX2JT
UT WOS:000384195700002
PM 27496374
OA Bronze
DA 2023-06-08
ER

PT J
AU Bahlouli, W
   Breton, J
   Lelouard, M
   L'Huillier, C
   Tirelle, P
   Salameh, E
   Amamou, A
   Atmani, K
   Goichon, A
   Bole-Feysot, C
   Ducrotte, P
   Ribet, D
   Dechelotte, P
   Coeffier, M
AF Bahlouli, Wafa
   Breton, Jonathan
   Lelouard, Mauranne
   L'Huillier, Clement
   Tirelle, Pauline
   Salameh, Emmeline
   Amamou, Asma
   Atmani, Karim
   Goichon, Alexis
   Bole-Feysot, Christine
   Ducrotte, Philippe
   Ribet, David
   Dechelotte, Pierre
   Coeffier, Moise
TI Stress-induced intestinal barrier dysfunction is exacerbated during
   diet-induced obesity
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Article
DE Morbid obesity; Irritable bowel syndrome; Gut barrier; Leptin;
   Metformin; Gut microbiota
ID IRRITABLE-BOWEL-SYNDROME; INCREASED GUT PERMEABILITY; SYNDROME
   INVOLVEMENT; LEPTIN; ENDOTOXEMIA; MICROBIOTA; CURCUMIN; DISEASE; COHORT;
   CELLS
AB Obesity and irritable bowel syndrome (IBS) are two major public health issues. Interestingly previous data report a marked increase of IBS prevalence in morbid obese subjects compared with non-obese subjects but underlying mechanisms remain unknown. Obesity and IBS share common intestinal pathophysiological mechanisms such as gut dysbiosis, intestinal hyperpermeability and low-grade inflammatory response. We thus aimed to evaluate the link between obesity and IBS using different animal models. Male C57Bl/6 mice received high fat diet (HFD) for 12 weeks and were then submitted to water avoidance stress (WAS). In response to WAS, HFD mice exhibited higher intestinal permeability and plasma corticosterone concentration than non-obese mice. We were not able to reproduce a similar response both in ob/ob mice and in leptin-treated non-obese mice. In addition, metformin, a hypoglycemic agent, limited fasting glycaemia both in unstressed and WAS diet-induced obese mice but only partially restored colonic permeability in unstressed HFD mice. Metformin failed to improve intestinal permeability in WAS HFD mice. Finally, cecal microbiota transplantation from HFD mice in antibiotics-treated recipient mice did not reproduce the effects observed in stressed HFD mice. In conclusion, stress induced a more marked intestinal barrier dysfunction in diet-induced obese mice compared with non-obese mice that seems to be independent of leptin, glycaemia and gut microbiota. These data should be further confirmed and the role of the dietary composition should be studied. (C) 2020 Elsevier Inc. All rights reserved.
C1 [Bahlouli, Wafa; Breton, Jonathan; Lelouard, Mauranne; L'Huillier, Clement; Tirelle, Pauline; Salameh, Emmeline; Amamou, Asma; Atmani, Karim; Goichon, Alexis; Bole-Feysot, Christine; Ducrotte, Philippe; Ribet, David; Dechelotte, Pierre; Coeffier, Moise] Normandie Univ, UNIROUEN, INSERM, UMR 1073,Nutr Inflammat & Gut Brain Axis, F-76183 Rouen, France.
   [Bahlouli, Wafa; Breton, Jonathan; Lelouard, Mauranne; L'Huillier, Clement; Tirelle, Pauline; Salameh, Emmeline; Amamou, Asma; Atmani, Karim; Goichon, Alexis; Bole-Feysot, Christine; Ducrotte, Philippe; Ribet, David; Dechelotte, Pierre; Coeffier, Moise] UNIROUEN, Inst Res & Innovat Biomed IRIB, F-76183 Rouen, France.
   [Ducrotte, Philippe] Rouen Univ Hosp, Dept Gastroenterol, F-76183 Rouen, France.
   [Dechelotte, Pierre; Coeffier, Moise] Rouen Univ Hosp, Dept Nutr, F-76183 Rouen, France.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite de Rouen Normandie; Universite de Rouen Normandie; Universite
   de Rouen Normandie; CHU de Rouen; Universite de Rouen Normandie; CHU de
   Rouen
RP Coeffier, M (通讯作者)，Normandie Univ, UNIROUEN, INSERM, UMR 1073,Nutr Inflammat & Gut Brain Axis, F-76183 Rouen, France.; Coeffier, M (通讯作者)，UNIROUEN, Inst Res & Innovat Biomed IRIB, F-76183 Rouen, France.; Coeffier, M (通讯作者)，Rouen Univ Hosp, Dept Nutr, F-76183 Rouen, France.
EM moise.coeffier@univ-rouen.fr
RI Atmani, Karim/AAR-6116-2020; Atmani, Karim/HLH-8541-2023; Breton,
   jonathan/ABA-2327-2021; Ribet, David/AAA-6659-2020
OI Atmani, Karim/0000-0003-3584-0694; Ribet, David/0000-0003-1175-6471;
   BRETON, Jonathan/0000-0001-5359-5210; Coeffier,
   Moise/0000-0002-7469-2682; DECHELOTTE, Pierre/0000-0001-5224-6166
FU Microbiome foundation; Roquette foundation for health; European Union;
   Normandie Regional Council
FX This work was co-supported by the Microbiome foundation, the Roquette
   foundation for health and by European Union and Normandie Regional
   Council (to W.B. and for equipment). Europe gets involved in Normandie
   with European Regional Development Fund (ERDF). These funders did not
   participate in the design, implementation, analysis, and interpretation
   of the data.
CR Aasbrenn M, 2018, SCAND J CLIN LAB INV, V78, P109, DOI 10.1080/00365513.2017.1419372
   Agostini S, 2012, NEUROGASTROENT MOTIL, V24, DOI 10.1111/j.1365-2982.2011.01865.x
   Annahazi A, 2013, AM J GASTROENTEROL, V108, P1322, DOI 10.1038/ajg.2013.152
   [Anonymous], F1000RES
   Bashashati M, 2018, NEUROGASTROENT MOTIL, V30, DOI 10.1111/nmo.13192
   Bertiaux-Vandaele N, 2011, AM J GASTROENTEROL, V106, P2165, DOI 10.1038/ajg.2011.257
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Carter D, 2015, J CLIN GASTROENTEROL, V49, P300, DOI 10.1097/MCG.0000000000000114
   Chen L, 2018, FRONT PHARMACOL, V9, DOI 10.3389/fphar.2018.00761
   Coeffier M, 2010, AM J GASTROENTEROL, V105, P1181, DOI 10.1038/ajg.2009.700
   Costea PI, 2017, NAT BIOTECHNOL, V35, P1069, DOI 10.1038/nbt.3960
   Cotillard A, 2013, NATURE, V500, P585, DOI 10.1038/nature12480
   Damms-Machado A, 2017, AM J CLIN NUTR, V105, P127, DOI 10.3945/ajcn.116.131110
   de La Serre CB, 2010, AM J PHYSIOL-GASTR L, V299, pG440, DOI 10.1152/ajpgi.00098.2010
   Deng J, 2018, J CELL MOL MED, V22, P546, DOI 10.1111/jcmm.13342
   Dunlop SP, 2006, AM J GASTROENTEROL, V101, P1288, DOI 10.1111/j.1572-0241.2006.00672.x
   Fierer N, 2005, APPL ENVIRON MICROB, V71, P4117, DOI 10.1128/AEM.71.7.4117-4120.2005
   Ford AC, 2017, NEW ENGL J MED, V376, P2566, DOI 10.1056/NEJMra1607547
   Francois M, 2016, NUTRITION, V32, P709, DOI 10.1016/j.nut.2015.12.034
   Gallus S, 2015, EUR J NUTR, V54, P679, DOI 10.1007/s00394-014-0746-4
   Ghouzali I, 2017, BBA-GEN SUBJECTS, V1861, P3278, DOI 10.1016/j.bbagen.2016.08.010
   Goichon A, 2019, J PROTEOME RES, V18, P478, DOI 10.1021/acs.jproteome.8b00793
   Gomez-Zorita S, 2019, NUTRIENTS, V11, DOI 10.3390/nu11092156
   Herrmann JR, 2016, AM J PHYSIOL-CELL PH, V310, pC423, DOI 10.1152/ajpcell.00348.2015
   Queipo-Ortuno MI, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0065465
   Jesus P, 2014, CLIN NUTR, V33, P1046, DOI 10.1016/j.clnu.2013.11.006
   Johnson AMF, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0122195
   Kilkenny C, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0007824
   Kim CY, 2014, J NUTR BIOCHEM, V25, P26, DOI 10.1016/j.jnutbio.2013.08.011
   Le Drean G, 2014, TISSUE BARRIERS, V2, DOI 10.4161/21688362.2014.970940
   Le Drean G, 2014, FASEB J, V28, P1059, DOI 10.1096/fj.13-234203
   Le Pluart D, 2015, ALIMENT PHARM THER, V41, P758, DOI 10.1111/apt.13143
   Marques A, 2018, EUR J PUBLIC HEALTH, V28, P295, DOI 10.1093/eurpub/ckx143
   Martinez C, 2013, GUT, V62, P1160, DOI 10.1136/gutjnl-2012-302093
   Martinez C, 2012, AM J GASTROENTEROL, V107, P736, DOI 10.1038/ajg.2011.472
   Maurya R, 2016, AM J TROP MED HYG, V95, P109, DOI 10.4269/ajtmh.15-0804
   Miquel S, 2016, SCI REP-UK, V6, DOI 10.1038/srep19399
   Nagpal R, 2018, J DIABETES RES, V2018, DOI 10.1155/2018/3462092
   Nozu T, 2019, J GASTROEN HEPATOL, V34, P186, DOI 10.1111/jgh.14367
   Piche T, 2009, GUT, V58, P196, DOI 10.1136/gut.2007.140806
   Pickett-Blakely Octavia, 2014, Gastroenterol Hepatol (N Y), V10, P411
   Pugliese G, 2019, HORM-INT J ENDOCRINO, V18, P395, DOI 10.1007/s42000-019-00113-9
   Rena G, 2017, DIABETOLOGIA, V60, P1577, DOI 10.1007/s00125-017-4342-z
   Schneck AS, 2016, OBES SURG, V26, P1525, DOI 10.1007/s11695-015-1907-0
   Spiller RC, 2000, GUT, V47, P804, DOI 10.1136/gut.47.6.804
   Stenman LK, 2013, BRIT J NUTR, V110, P1157, DOI 10.1017/S000711451300024X
   Teixeira TFS, 2012, CLIN NUTR, V31, P735, DOI 10.1016/j.clnu.2012.02.009
   Thaiss CA, 2018, SCIENCE, V359, P1376, DOI 10.1126/science.aar3318
   Turnbaugh PJ, 2008, CELL HOST MICROBE, V3, P213, DOI 10.1016/j.chom.2008.02.015
   Ye C, 2018, INT J OBESITY, V42, P1471, DOI 10.1038/s41366-018-0125-y
   Yu YC, 2015, METAB BRAIN DIS, V30, P47, DOI 10.1007/s11011-014-9554-z
   Zhang PP, 2019, ADV MATER, V31, DOI 10.1002/adma.201806005
   Zhao Y, 2018, HIGH POWER LASER PAR, V30, P2, DOI DOI 10.1111/NM0.13161
   Zhou QQ, 2019, GUT, V68, P996, DOI 10.1136/gutjnl-2017-315136
   Zhou QQ, 2009, PAIN, V146, P41, DOI 10.1016/j.pain.2009.06.017
   Zhou ZY, 2016, ACTA PHARMACOL SIN, V37, P1063, DOI 10.1038/aps.2016.21
   Zhu H, 2017, EUR REV MED PHARMACO, V21, P5239, DOI 10.26355/eurrev_201711_13847
NR 57
TC 8
Z9 8
U1 5
U2 10
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD JUL
PY 2020
VL 81
AR 108382
DI 10.1016/j.jnutbio.2020.108382
PG 11
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA LT2VF
UT WOS:000536929100010
PM 32417626
OA Green Published, Bronze
DA 2023-06-08
ER

PT J
AU Almugadam, BS
   Liu, YH
   Chen, SM
   Wang, CH
   Shao, CY
   Ren, BW
   Tang, L
AF Almugadam, Babiker Saad
   Liu, Yinhui
   Chen, Shen-min
   Wang, Chun-hao
   Shao, Chen-yi
   Ren, Bao-wei
   Tang, Li
TI Alterations of Gut Microbiota in Type 2 Diabetes Individuals and the
   Confounding Effect of Antidiabetic Agents
SO JOURNAL OF DIABETES RESEARCH
LA English
DT Article
ID CHAIN FATTY-ACIDS; EPIDEMIOLOGY; ASSOCIATION; SEQUENCES; BUTYRATE
AB Type 2 diabetes is a leading cause of morbidity and a common risk of several disorders. Identifying the microbial ecology changes is essential for disease prediction, therapy, and prevention. Thus, our study is aimed at investigating the intestinal microbiota among healthy and type 2 diabetes individuals and exploring the effect of antidiabetic agents on gut bacterial flora. 24 type 2 diabetes (metformin, glimepiride, and nontherapeutic subgroups;N=8) and 24 healthy control subjects were enrolled in this study, and intestinal bacterial microbiota was investigated by analyzing V3-V4 regions of 16S rRNA gene sequence. Numerous alterations were observed in the gut microbial community of diabetic individuals. These changes were characterized by a significant lowered abundance ofFaecalibacterium,Fusobacterium,Dialister, andElusimicrobiumin the nontherapeutic subgroup compared to the healthy control group. Likewise, correlation analysis showed a substantial decline in gut microbiota richness and diversity with the duration of illness. Furthermore, antidiabetic agents restored to some extent the richness and diversity of gut microbiota and improved the abundance of many beneficial bacteria with a significant increase ofMethanobrevibacterin the metformin subcategory compared to the nontherapeutic subgroup. In return, they decreased the abundance of some opportunistic pathogens. The findings of this study have added a novel understanding about the pathogenesis of the disease and the mechanisms underlying antidiabetic therapy, which are of potential interest for therapeutic lines and further studies.
C1 [Almugadam, Babiker Saad; Liu, Yinhui; Chen, Shen-min; Wang, Chun-hao; Shao, Chen-yi; Ren, Bao-wei; Tang, Li] Dalian Med Univ, Dept Microecol, Coll Basic Med Sci, Dalian, Liaoning, Peoples R China.
   [Almugadam, Babiker Saad] Univ El Imam El Mahdi, Fac Med Lab Sci, Dept Microbiol, Kosti, White Nile Stat, Sudan.
C3 Dalian Medical University
RP Tang, L (通讯作者)，Dalian Med Univ, Dept Microecol, Coll Basic Med Sci, Dalian, Liaoning, Peoples R China.
EM babiker888@yahoo.com; yhliu_dl@163.com; 18031500055@163.com;
   15124313326@163.com; 1058506994@qq.com; leo_maki@126.com;
   tangli_2015cn@sina.com
RI Almugadam, Babiker Saad/AGO-5640-2022
FU National Natural Science Foundation of China [81970719]
FX We are thankful to the study participants. The authors also acknowledge
   the staff of Namuzaji Center (National Health Insurance Fund) for their
   help throughout data and specimen collection. This work supported by the
   National Natural Science Foundation of China (No. 81970719).
CR Ahmad A, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0226372
   Alwan A, 2011, GLOBAL STATUS REPORT ON NONCOMMUNICABLE DISEASES 2010, P9
   Ami Patel, 2013, Croatian Journal of Food Science and Technology, V5, P85
   Canfora EE, 2015, NAT REV ENDOCRINOL, V11, P577, DOI 10.1038/nrendo.2015.128
   Chambers Edward S, 2018, Curr Nutr Rep, V7, P198, DOI 10.1007/s13668-018-0248-8
   Chatterjee S, 2017, LANCET, V389, P2239, DOI 10.1016/S0140-6736(17)30058-2
   Cheesbrough M., 2005, DISTRICT LAB PRACTIC
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Edgar RC, 2004, NUCLEIC ACIDS RES, V32, P1792, DOI 10.1093/nar/gkh340
   Edgar RC, 2013, NAT METHODS, V10, P996, DOI [10.1038/nmeth.2604, 10.1038/NMETH.2604]
   Edgar RC, 2011, BIOINFORMATICS, V27, P2194, DOI 10.1093/bioinformatics/btr381
   Fisher K, 2009, MICROBIOL-SGM, V155, P1749, DOI 10.1099/mic.0.026385-0
   Haas BJ, 2011, GENOME RES, V21, P494, DOI 10.1101/gr.112730.110
   Jandhyala SM, 2017, SCI REP-UK, V7, DOI 10.1038/srep43640
   Jandhyala SM, 2015, WORLD J GASTROENTERO, V21, P8787, DOI 10.3748/wjg.v21.i29.8787
   Jans C, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.00603
   Kaiser AB, 2018, DIABETES, V67, DOI 10.2337/db18-202-LB
   Kasubuchi M, 2015, NUTRIENTS, V7, P2839, DOI 10.3390/nu7042839
   Liu H, 2018, ADV NUTR, V9, P21, DOI 10.1093/advances/nmx009
   Magnusdottir S, 2015, FRONT GENET, V6, DOI 10.3389/fgene.2015.00148
   Maniar K, 2017, PHARMACOL RES, V117, P103, DOI 10.1016/j.phrs.2016.12.003
   Martin M., 2011, EMBNET J, V17, P10, DOI DOI 10.14806/EJ.17.1.200
   Parkar SG, 2019, MICROORGANISMS, V7, DOI 10.3390/microorganisms7020041
   Pettigrew MM, 2016, ANN EPIDEMIOL, V26, P342, DOI 10.1016/j.annepidem.2016.02.007
   Prattichizzo F, 2018, AGEING RES REV, V48, P87, DOI 10.1016/j.arr.2018.10.003
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Quast C, 2013, NUCLEIC ACIDS RES, V41, pD590, DOI 10.1093/nar/gks1219
   Rinninella E, 2019, MICROORGANISMS, V7, DOI 10.3390/microorganisms7010014
   Riviere A, 2016, FRONT MICROBIOL, V7, DOI 10.3389/fmicb.2016.00979
   Salamon D, 2018, POL ARCH INTERN MED, V128, P336, DOI 10.20452/pamw.4246
   Sedighi M, 2017, MICROB PATHOGENESIS, V111, P362, DOI 10.1016/j.micpath.2017.08.038
   Tao SB, 2019, ACTA DIABETOL, V56, P581, DOI 10.1007/s00592-019-01316-7
   Tong XL, 2018, MBIO, V9, DOI 10.1128/mBio.02392-17
   Wang Q, 2007, APPL ENVIRON MICROB, V73, P5261, DOI 10.1128/AEM.00062-07
   Wang Z, 2018, FRONT CELL INFECT MI, V8, DOI 10.3389/fcimb.2018.00301
   Weiss GA, 2017, CELL MOL LIFE SCI, V74, P2959, DOI 10.1007/s00018-017-2509-x
   Yamaguchi Y, 2016, DIGESTION, V94, P66, DOI 10.1159/000447690
   Yang Q, 2018, NAT REV MOL CELL BIO, V19, P654, DOI 10.1038/s41580-018-0044-8
   Zhang FH, 2019, ENDOCRINE, V66, P485, DOI 10.1007/s12020-019-02041-5
   Zheng Y, 2018, NAT REV ENDOCRINOL, V14, P88, DOI 10.1038/nrendo.2017.151
NR 40
TC 12
Z9 12
U1 1
U2 7
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6745
EI 2314-6753
J9 J DIABETES RES
JI J. Diabetes Res.
PD SEP 28
PY 2020
VL 2020
AR 7253978
DI 10.1155/2020/7253978
PG 14
WC Endocrinology & Metabolism; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Research & Experimental Medicine
GA OI4IE
UT WOS:000583243600001
PM 33062716
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Bellerba, F
   Chatziioannou, AC
   Jasbi, P
   Robinot, N
   Keski-Rahkonen, P
   Trolat, A
   Vozar, B
   Hartman, SJ
   Scalbert, A
   Bonanni, B
   Johansson, H
   Sears, DD
   Gandini, S
AF Bellerba, Federica
   Chatziioannou, Anastasia Chrysovalantou
   Jasbi, Paniz
   Robinot, Nivonirina
   Keski-Rahkonen, Pekka
   Trolat, Amarine
   Vozar, Beatrice
   Hartman, Sheri J.
   Scalbert, Augustin
   Bonanni, Bernardo
   Johansson, Harriet
   Sears, Dorothy D.
   Gandini, Sara
TI Metabolomic profiles of metformin in breast cancer survivors: a pooled
   analysis of plasmas from two randomized placebo-controlled trials
SO JOURNAL OF TRANSLATIONAL MEDICINE
LA English
DT Article
DE Cancer; Recurrence; Metabolic syndrome; Prevention; Lipids; Weight loss
ID GUT MICROBIOME; AMINO-ACIDS; FATTY-ACIDS; IN-VIVO; CYP1A2; RISK;
   INDIVIDUALS; ASSOCIATION; CITRULLINE; MORTALITY
AB Background: Obesity is a major health concern for breast cancer survivors, being associated with high recurrence and reduced efficacy during cancer treatment. Metformin treatment is associated with reduced breast cancer incidence, recurrence and mortality. To better understand the underlying mechanisms through which metformin may reduce recurrence, we aimed to conduct metabolic profiling of overweight/obese breast cancer survivors before and after metformin treatment. Methods: Fasting plasma samples from 373 overweight or obese breast cancer survivors randomly assigned to metformin (n = 194) or placebo (n = 179) administration were collected at baseline, after 6 months (Reach For Health trial), and after 12 months (MetBreCS trial). Archival samples were concurrently analyzed using three complementary methods: untargeted LC-QTOF-MS metabolomics, targeted LC-MS metabolomics (AbsoluteIDQ p180, Biocrates), and gas chromatography phospholipid fatty acid assay. Multivariable linear regression models and family-wise error correction were used to identify metabolites that significantly changed after metformin treatment. Results: Participants (n = 352) with both baseline and study end point samples available were included in the analysis. After adjusting for confounders such as study center, age, body mass index and false discovery rate, we found that metformin treatment was significantly associated with decreased levels of citrulline, arginine, tyrosine, caffeine, paraxanthine, and theophylline, and increased levels of leucine, isoleucine, proline, 3-methyl-2-oxovalerate, 4-methyl-2-oxovalerate, alanine and indoxyl-sulphate. Long-chain unsaturated phosphatidylcholines (PC ae C36:4, PC ae C38:5, PC ae C36:5 and PC ae C38:6) were significantly decreased with the metformin treatment, as were phospholipid-derived long-chain n-6 fatty acids. The metabolomic profiles of metformin treatment suggest change in specific biochemical pathways known to impair cancer cell growth including activation of CYP1A2, alterations in fatty acid desaturase activity, and altered metabolism of specific amino acids, including impaired branched chain amino acid catabolism. Conclusions: Our results in overweight breast cancer survivors identify new metabolic effects of metformin treatment that may mechanistically contribute to reduced risk of recurrence in this population and reduced obesity-related cancer risk reported in observational studies.
C1 [Bellerba, Federica; Gandini, Sara] European Inst Oncol IRCCS, Dept Expt Oncol, IEO, Milan, Italy.
   [Chatziioannou, Anastasia Chrysovalantou; Robinot, Nivonirina; Keski-Rahkonen, Pekka; Trolat, Amarine; Vozar, Beatrice; Scalbert, Augustin] Int Agcy Res Canc, Nutr & Metab Branch, Lyon, France.
   [Jasbi, Paniz; Sears, Dorothy D.] Arizona State Univ, Coll Hlth Solut, Phoenix, AZ USA.
   [Jasbi, Paniz] Arizona State Univ, Sch Mol Sci, Tempe, AZ USA.
   [Hartman, Sheri J.] Univ Calif San Diego, Herbert Wertheim Sch Publ Hlth & Human Longev Sci, La Jolla, CA USA.
   [Hartman, Sheri J.; Sears, Dorothy D.] Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA USA.
   [Bonanni, Bernardo; Johansson, Harriet] European Inst Oncol IRCCS, Div Canc Prevent & Genet, IEO, Via Giuseppe Ripamonti 435, I-20141 Milan, Italy.
   [Sears, Dorothy D.] Univ Calif San Diego, Dept Med, La Jolla, CA USA.
C3 IRCCS European Institute of Oncology (IEO); World Health Organization;
   International Agency for Research on Cancer (IARC); Arizona State
   University; Arizona State University-Downtown Phoenix; Arizona State
   University; Arizona State University-Tempe; University of California
   System; University of California San Diego; University of California
   System; University of California San Diego; IRCCS European Institute of
   Oncology (IEO); University of California System; University of
   California San Diego
RP Johansson, H (通讯作者)，European Inst Oncol IRCCS, Div Canc Prevent & Genet, IEO, Via Giuseppe Ripamonti 435, I-20141 Milan, Italy.
EM harriet.johansson@ieo.it
OI Johansson, Harriet/0000-0002-4131-2030
FU National Institutes of Health [U54 CA155435]; Italian Ministry of Health
   [RRC-2014-2354553]; Institut National du Cancer, France (INCa) through
   the TRANSCAN ERA-Net call on Translational Cancer Research (TRANSCAN-JTC
   2013) [2015-034]; Research Council Norway/Norwegian Cancer Society;
   Italian Ministry of Health
FX Reach for Health study was supported by the National Institutes of
   Health (U54 CA155435) and the MetBreCs trial was supported by the
   Italian Ministry of Health (RRC-2014-2354553) and the Institut National
   du Cancer, France (INCa No2015-034), through the TRANSCAN ERA-Net call
   on Translational Cancer Research (TRANSCAN-JTC 2013). The biomarker
   analyses were conducted within the European Commission (EC) Seventh
   Framework Program (FP7) Translational by grants from the research
   Council Norway/Norwegian Cancer Society (steroid profiling) and Italian
   Ministry of Health (adipokines, cytokines, growth factors, inflammatory
   biomarkers). This work was partially supported by the Italian Ministry
   of Health with Ricerca Corrente and 5 x 1000 funds. Federica Bellerba is
   a Ph.D. student within the European School of Molecular Medicine (SEMM).
CR Agius L, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21093240
   Agus A, 2021, GUT, V70, P1174, DOI 10.1136/gutjnl-2020-323071
   [Anonymous], METF EFF DRUG MET PA
   Arrieta O, 2019, JAMA ONCOL, V5, DOI 10.1001/jamaoncol.2019.2553
   Ayari I, 2013, MOL MED REP, V7, P280, DOI 10.3892/mmr.2012.1164
   Azrad M, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0053104
   Baker JM, 2017, MATURITAS, V103, P45, DOI 10.1016/j.maturitas.2017.06.025
   Batista MA, 2012, JPEN-PARENTER ENTER, V36, P69, DOI 10.1177/0148607111414024
   Bendinelli B, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-92508-1
   Breier M, 2017, J STEROID BIOCHEM, V174, P114, DOI 10.1016/j.jsbmb.2017.08.004
   Carrillo JA, 2000, THER DRUG MONIT, V22, P409, DOI 10.1097/00007691-200008000-00008
   Chajes V, 2017, ANN ONCOL, V28, P2836, DOI 10.1093/annonc/mdx482
   Davis BJ, 2006, DIABETES, V55, P496, DOI 10.2337/diabetes.55.02.06.db05-1064
   Elfaki Imadeldin, 2018, Asian Pac J Cancer Prev, V19, P2057
   Elia I, 2017, NAT COMMUN, V8, DOI 10.1038/ncomms15267
   Floegel A, 2013, DIABETES, V62, P639, DOI 10.2337/db12-0495
   Friedman J, 2008, BIOSTATISTICS, V9, P432, DOI 10.1093/biostatistics/kxm045
   Gandini S, 2014, CANCER PREV RES, V7, P867, DOI 10.1158/1940-6207.CAPR-13-0424
   Geijsen AJMR, 2019, INT J CANCER, V145, P1221, DOI 10.1002/ijc.32146
   Ha JR, 2016, J CELL BIOCHEM, V117, P1971, DOI 10.1002/jcb.25561
   He JL, 2016, J DIABETES, V8, P305, DOI 10.1111/1753-0407.12358
   Imene Ayari, 2015, Asian Pac J Cancer Prev, V16, P3559
   Irving BA, 2015, METABOLISM, V64, P720, DOI 10.1016/j.metabol.2015.01.008
   Jasbi P, 2019, J CHROMATOGR B, V1105, P26, DOI 10.1016/j.jchromb.2018.11.029
   Kim E, 2011, DIABETES, V60, P1493, DOI 10.2337/db10-0393
   Kim W, 2019, CELL METAB, V29, P856, DOI 10.1016/j.cmet.2018.12.023
   Kotsopoulos J, 2007, CANCER EPIDEM BIOMAR, V16, P912, DOI 10.1158/1055-9965.EPI-06-1074
   Kwee LC, 2021, NUTR DIABETES, V11, DOI 10.1038/s41387-021-00151-6
   Li Lei O, 2010, Mol Endocrinol, V24, P657, DOI 10.1210/me.2009-0152
   Li L, 2013, ANAL CHEM, V85, P3401, DOI 10.1021/ac400099b
   Madiraju AK, 2018, NAT MED, V24, P1384, DOI 10.1038/s41591-018-0125-4
   Madiraju AK, 2014, NATURE, V510, P542, DOI 10.1038/nature13270
   Martinez-Reyes I, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-019-13668-3
   Matzke GR, 2000, PHARMACOTHERAPY, V20, P182, DOI 10.1592/phco.20.3.182.34775
   McCarty MF, 2018, NUTR CANCER, V70, P840, DOI 10.1080/01635581.2018.1470657
   Miklankova D, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22147680
   Miller KD, 2019, CA-CANCER J CLIN, V69, P363, DOI 10.3322/caac.21565
   Patterson RE, 2018, JNCI-J NATL CANCER I, V110, DOI 10.1093/jnci/djy040
   Patterson RE, 2016, CONTEMP CLIN TRIALS, V47, P64, DOI 10.1016/j.cct.2015.12.009
   Peng H, 2020, ONCOGENE, V39, P6747, DOI 10.1038/s41388-020-01480-z
   Pernicova I, 2014, NAT REV ENDOCRINOL, V10, P143, DOI 10.1038/nrendo.2013.256
   Picon-Ruiz M, 2017, CA-CANCER J CLIN, V67, P379, DOI 10.3322/caac.21405
   Preethika A, 2022, GENE, V823, DOI 10.1016/j.gene.2022.146330
   Safai N, 2018, DIABETIC MED, V35, P944, DOI 10.1111/dme.13636
   Siegel Rebecca, 2014, CA Cancer J Clin, V64, P9, DOI 10.3322/caac.21208
   Smith TAD, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0151179
   Sonnet DS, 2016, SCI REP-UK, V6, DOI 10.1038/srep28775
   Sumner LW, 2007, METABOLOMICS, V3, P211, DOI 10.1007/s11306-007-0082-2
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Sung H, 2021, CA-CANCER J CLIN, V71, P209, DOI 10.3322/caac.21660
   Takahashi H, 2018, CHIN CLIN ONCOL, V7, DOI 10.21037/cco.2018.05.06
   Tibshirani R, 1996, J ROY STAT SOC B MET, V58, P267, DOI 10.1111/j.2517-6161.1996.tb02080.x
   Urry E, 2016, NUTR METAB, V13, DOI 10.1186/s12986-016-0126-6
   van de Poll MCG, 2004, AM J CLIN NUTR, V79, P185
   Vinaixa M, 2012, METABOLITES, V2, P775, DOI 10.3390/metabo2040775
   Wei YP, 2021, J PROTEOME RES, V20, P3124, DOI 10.1021/acs.jproteome.1c00019
   Westphal C, 2011, PROSTAG OTH LIPID M, V96, P99, DOI 10.1016/j.prostaglandins.2011.09.001
   Wishart DS, 2018, NUCLEIC ACIDS RES, V46, pD608, DOI 10.1093/nar/gkx1089
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Xu T, 2015, DIABETES CARE, V38, P1858, DOI 10.2337/dc15-0658
   Xue PP, 2017, EBIOMEDICINE, V20, P50, DOI 10.1016/j.ebiom.2017.05.001
   Ye ZH, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.00617
   Yerevanian A, 2019, CURR OBES REP, V8, P156, DOI 10.1007/s13679-019-00335-3
   Zhang GD, 2014, PROG LIPID RES, V53, P108, DOI 10.1016/j.plipres.2013.11.003
   Zhang L, 2017, BIOCHEM BIOPH RES CO, V486, P224, DOI 10.1016/j.bbrc.2017.02.101
   Zhao WP, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-88258-9
NR 66
TC 0
Z9 0
U1 4
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1479-5876
J9 J TRANSL MED
JI J. Transl. Med.
PD DEC 29
PY 2022
VL 20
IS 1
AR 629
DI 10.1186/s12967-022-03809-6
PG 16
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 7L4CK
UT WOS:000905915800001
PM 36581893
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Bahler, L
   Holleman, F
   Chan, MW
   Booij, J
   Hoekstra, JB
   Verberne, HJ
AF Bahler, Lonneke
   Holleman, Frits
   Chan, Man-Wai
   Booij, Jan
   Hoekstra, Joost B.
   Verberne, Hein J.
TI F-18-FDG uptake in the colon is modulated by metformin but not
   associated with core body temperature and energy expenditure
SO PLOS ONE
LA English
DT Article
ID GLUCOSE-METABOLISM; DIABETES-MELLITUS; GUT MICROBIOTA; TRANSIT-TIME;
   DOUBLE-BLIND; PET; DISCONTINUATION; ABSORPTION; INTESTINE; OBESITY
AB Purpose
   Physiological colonic F-18-fluorodeoxyglucose (F-18-FDG) uptake is a frequent finding on F-18-FDG positron emission tomography computed tomography (PET-CT). Interestingly, metformin, a glucose lowering drug associated with moderate weight loss, is also associated with an increased colonic F-18-FDG uptake. Consequently, increased colonic glucose use might partly explain the weight losing effect of metformin when this results in an increased energy expenditure and/or core body temperature. Therefore, we aimed to determine whether metformin modifies the metabolic activity of the colon by increasing glucose uptake.
   Methods
   In this open label, non-randomized, prospective mechanistic study, we included eight lean and eight overweight males. We measured colonic F-18-FDG uptake on PET-CT, energy expenditure and core body temperature before and after the use of metformin. The maximal colonic F-18-FDG uptake was measured in 5 separate segments (caecum, colon ascendens, -transversum, -descendens and sigmoid).
   Results
   The maximal colonic F-18-FDG uptake increased significantly in all separate segments after the use of metformin. There was no significant difference in energy expenditure or core body temperature after the use of metformin. There was no correlation between maximal colonic F-18-FDG uptake and energy expenditure or core body temperature.
   Conclusion
   Metformin significantly increases colonic F-18-FDG uptake, but this increased uptake is not associated with an increase in energy expenditure or core body temperature. Although the colon might be an important site of the glucose plasma lowering actions of metformin, this mechanism of action does not explain directly any associated weight loss.
C1 [Bahler, Lonneke; Holleman, Frits; Chan, Man-Wai; Hoekstra, Joost B.] Acad Med Ctr, Internal Med, Amsterdam, Netherlands.
   [Booij, Jan; Verberne, Hein J.] Acad Med Ctr, Nucl Med, Amsterdam, Netherlands.
C3 University of Amsterdam; Academic Medical Center Amsterdam; University
   of Amsterdam; Academic Medical Center Amsterdam
RP Bahler, L (通讯作者)，Acad Med Ctr, Internal Med, Amsterdam, Netherlands.
EM l.bahler@amc.uva.nl
RI Booij, Jan/AAD-7159-2019
CR Bahler L, 2016, DIABETES RES CLIN PR, V114, P55, DOI 10.1016/j.diabres.2016.02.009
   BAILEY CJ, 1994, BRIT J PHARMACOL, V112, P671, DOI 10.1111/j.1476-5381.1994.tb13128.x
   BAILEY CJ, 1992, BRIT J PHARMACOL, V105, P1009, DOI 10.1111/j.1476-5381.1992.tb09093.x
   BOUCHOUCHA M, 1992, DIS COLON RECTUM, V35, P773, DOI 10.1007/BF02050328
   BROOKS SL, 1981, BIOSCIENCE REP, V1, P509, DOI 10.1007/BF01121584
   Bybel B, 2011, CLIN NUCL MED, V36, P452, DOI 10.1097/RLU.0b013e318217399e
   Byrne C, 2007, BRIT J SPORT MED, V41, P126, DOI 10.1136/bjsm.2006.026344
   CASEY C, 1979, BRIT J CLIN PHARMACO, V8, pP382, DOI 10.1111/j.1365-2125.1979.tb04729.x
   Chen CH, 2013, J CLIN PSYCHIAT, V74, pE424, DOI 10.4088/JCP.12m08186
   Christensen MMH, 2011, PHARMACOGENET GENOM, V21, P837, DOI 10.1097/FPC.0b013e32834c0010
   Delzenne NM, 2015, DIABETOLOGIA, V58, P2206, DOI 10.1007/s00125-015-3712-7
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Giannarelli R, 2003, DIABETES METAB, V29, pS28
   Gontier E, 2008, EUR J NUCL MED MOL I, V35, P95, DOI 10.1007/s00259-007-0563-6
   Honka H, 2013, DIABETOLOGIA, V56, P893, DOI 10.1007/s00125-012-2825-5
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kendall D, 2013, J CLIN ENDOCR METAB, V98, P322, DOI 10.1210/jc.2012-2710
   Knowler WC, 2002, NEW ENGL J MED, V346, P393, DOI 10.1056/NEJMoa012512
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   LONG CL, 1967, METABOLISM, V16, P413, DOI 10.1016/0026-0495(67)90132-1
   Mardinoglu A, 2016, CELL METAB, V23, P10, DOI 10.1016/j.cmet.2015.12.012
   Massollo M, 2013, J NUCL MED, V54, P259, DOI 10.2967/jnumed.112.106666
   McCreight LJ, 2016, DIABETOLOGIA, V59, P426, DOI 10.1007/s00125-015-3844-9
   Oh JR, 2010, AM J ROENTGENOL, V195, P1404, DOI 10.2214/AJR.10.4663
   Ozulker T, 2010, EUR J NUCL MED MOL I, V37, P1011, DOI 10.1007/s00259-009-1330-7
   PENICAUD L, 1989, BIOCHEM J, V262, P881, DOI 10.1042/bj2620881
   Proctor WR, 2008, DRUG METAB DISPOS, V36, P1650, DOI 10.1124/dmd.107.020180
   STUMVOLL M, 1995, NEW ENGL J MED, V333, P550, DOI 10.1056/NEJM199508313330903
   Swinburn BA, 2011, LANCET, V378, P804, DOI 10.1016/S0140-6736(11)60813-1
   Toriihara A, 2011, ANN NUCL MED, V25, P173, DOI 10.1007/s12149-010-0439-x
   TUCKER GT, 1981, BRIT J CLIN PHARMACO, V12, P235
   Tulk HMF, 2013, NUTR J, V12, DOI 10.1186/1475-2891-12-87
   WILCOCK C, 1990, BIOCHEM PHARMACOL, V39, P1831, DOI 10.1016/0006-2952(90)90136-9
NR 33
TC 13
Z9 13
U1 0
U2 2
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 2
PY 2017
VL 12
IS 5
AR e0176242
DI 10.1371/journal.pone.0176242
PG 15
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA ET9RV
UT WOS:000400646300014
PM 28464031
OA Green Submitted, Green Published, gold
DA 2023-06-08
ER

PT J
AU Ge, XD
   Chang, CE
   Chen, HL
   Liu, TT
   Chen, LG
   Huang, Y
   Zeng, F
   Liu, B
AF Ge, Xiaodong
   Chang, Chang'e
   Chen, Huiling
   Liu, Tingting
   Chen, Ligen
   Huang, Ying
   Zeng, Feng
   Liu, Bin
TI Luteolin cooperated with metformin hydrochloride alleviates lipid
   metabolism disorders and optimizes intestinal flora compositions of
   high-fat diet mice
SO FOOD & FUNCTION
LA English
DT Article
ID GRIFOLA-FRONDOSA; LIVER; INSULIN; CHOLESTEROL; GLUCOSE; TISSUE;
   POLYSACCHARIDE; ACTIVATION; ANTITUMOR; EXTRACTS
AB Luteolin (LU) is a flavonoid compound and metformin hydrochloride (MH) is a kind of drug. Studies have shown that both LU and MH have the function of hypoglycemic effect. However, there are few reports indicating that LU cooperated with MH (LU center dot MH) can relieve lipid metabolism disorders and optimize intestinal flora compositions of high-fat diet mice. In this research, we investigated the effects of LU, MH and LU center dot MH on lipid metabolism disorders and intestinal flora composition in high-fat diet mice. The study found that compared with high-fat diet (HFD) alone, LU, MH and LU center dot MH could significantly reduce the lipid metabolism disorder. Furthermore, compared with LU or MH alone, the biochemical indicators of LU center dot MH were significantly improved and the results of the histopathological section also showed that LU center dot MH has stronger liver repair ability. It revealed that the potential mechanisms of the LU center dot MH alleviating lipid metabolism disorders were involved in the simultaneous regulation of SREBP-1c/FAS and SREBP-1c/ACC/Cpt-1. In addition, LU center dot MH could regulate the intestinal flora compositions. This includes significantly reducing the ratio of Firmicutes and Bacteroidetes(F/B) and at the family level, increasing the relative abundance of Lachnospiraceae, Helicobacteraceae, Marinifilaceae and Peptococcaceae to relieve lipid metabolism disorders. In conclusion, the work found that LU center dot MH regulates the signal pathway of SREBP-1c/FAS and SREBP-1c/ACC/Cpt-1 simultaneously and decreases the ratio of F/B, as well as increases the relative abundance of certain microbiota to alleviate the lipid metabolism disorders of HFD-fed mice.
C1 [Ge, Xiaodong; Chang, Chang'e; Huang, Ying; Zeng, Feng; Liu, Bin] Fujian Agr & Forestry Univ, Coll Food Sci, Fuzhou 350002, Fujian, Peoples R China.
   [Chen, Huiling; Chen, Ligen] Yancheng Inst Technol, Coll Marine & Bioengn, Yancheng 224051, Jiangsu, Peoples R China.
   [Liu, Tingting] Yancheng Second Peoples Hosp, Clin Pharm Dept, Yancheng 224051, Jiangsu, Peoples R China.
   [Liu, Bin] Fujian Agr & Forestry Univ, Natl Engn Res Ctr JUNCAO Technol, Fuzhou 350002, Fujian, Peoples R China.
C3 Fujian Agriculture & Forestry University; Yancheng Institute of
   Technology; Fujian Agriculture & Forestry University
RP Zeng, F; Liu, B (通讯作者)，Fujian Agr & Forestry Univ, Coll Food Sci, Fuzhou 350002, Fujian, Peoples R China.; Liu, B (通讯作者)，Fujian Agr & Forestry Univ, Natl Engn Res Ctr JUNCAO Technol, Fuzhou 350002, Fujian, Peoples R China.
EM fengzengfzp@163.com; liubin618@hotmail.com
RI Liu, Tingting/F-3317-2019
OI Liu, Tingting/0000-0003-1161-5134
FU Fujian Agriculture and Forestry University International Cooperation
   Project [KXG15001A]; China Postdoctoral Science Foundation
   [2020M671918]; Fujian Agriculture and Forestry University Science and
   Technology Innovation Special Projects [CXZX2018055, CXZX2018056]
FX This work was funded by the Fujian Agriculture and Forestry University
   International Cooperation Project (No. KXG15001A), China Postdoctoral
   Science Foundation (No. 2020M671918) and the Fujian Agriculture and
   Forestry University Science and Technology Innovation Special Projects
   (No. CXZX2018055, CXZX2018056).
CR Abshagen K, 2019, J ADV RES, V16, P99, DOI 10.1016/j.jare.2018.11.003
   Aydin O, 2018, CURR DIABETES REP, V18, DOI 10.1007/s11892-018-1020-6
   Banerjee J, 2016, METABOLISM, V65, P1679, DOI 10.1016/j.metabol.2016.06.011
   Behr C, 2018, TOXICOL APPL PHARM, V355, P198, DOI 10.1016/j.taap.2018.06.028
   Chang CJ, 2017, NAT COMMUN, V8, DOI 10.1038/ncomms16130
   Chen GJ, 2018, MOL NUTR FOOD RES, V62, DOI 10.1002/mnfr.201700485
   Chen XY, 2019, J FOOD MEAS CHARACT, V13, P144, DOI 10.1007/s11694-018-9927-9
   Chen YF, 2011, HEPATOLOGY, V54, P562, DOI 10.1002/hep.24423
   Chipkin SR, 2005, AM J MED, V118, P4, DOI 10.1016/j.amjmed.2005.04.010
   Cotillard A, 2013, NATURE, V500, P585, DOI 10.1038/nature12480
   Czech MP, 2017, NAT MED, V23, P804, DOI 10.1038/nm.4350
   Fatima M., 2018, BIOMED RES-TOKYO, V29, P2285, DOI [10.4066/biomedicalresearch.40-18-526, DOI 10.4066/BIOMEDICALRESEARCH.40-18-526]
   Fu XB, 2014, PHARMACOL BIOCHEM BE, V126, P122, DOI 10.1016/j.pbb.2014.09.005
   Gkolfakis P, 2015, HEPATOB PANCREAT DIS, V14, P572, DOI 10.1016/S1499-3872(15)60026-1
   He K, 2016, FOOD FUNCT, V7, P3505, DOI 10.1039/c6fo00623j
   He YL, 2018, DISCOV MED, V25, P159
   Horton JD, 2002, J CLIN INVEST, V109, P1125, DOI 10.1172/JCI200215593
   Im E, 2018, LIFE SCI, V209, P259, DOI 10.1016/j.lfs.2018.08.025
   Jazayeri-Tehrani SA, 2019, NUTR METAB, V16, DOI 10.1186/s12986-019-0331-1
   Jesch Elliot D, 2017, Prev Nutr Food Sci, V22, P67, DOI 10.3746/pnf.2017.22.2.67
   Jin DX, 2019, J FUNCT FOODS, V52, P479, DOI 10.1016/j.jff.2018.11.031
   Kaakoush NO, 2015, FRONT CELL INFECT MI, V5, DOI [10.3309/fcimb.2015.00004, 10.3389/fcimb.2015.00084]
   Kang YB, 2019, INT J OBESITY, V43, P1631, DOI 10.1038/s41366-018-0187-x
   Kleiner DE, 2005, HEPATOLOGY, V41, P1313, DOI 10.1002/hep.20701
   Lee Y, 2019, BIOCHEM BIOPH RES CO, V517, P617, DOI 10.1016/j.bbrc.2019.07.073
   Li J, 2018, EXP THER MED, V16, P2593, DOI 10.3892/etm.2018.6499
   Li MR, 2019, FOOD FUNCT, V10, P3514, DOI 10.1039/c9fo00153k
   Li TT, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19103075
   Liang YH, 2018, ADV CIV ENG, V2018, DOI 10.1155/2018/9576496
   Lin L, 2020, FOOD FUNCT, V11, P1798, DOI [10.1039/c9fo02451d, 10.1039/C9FO02451D]
   Liu HL, 2016, J LIPID RES, V57, P1831, DOI 10.1194/jlr.M069807
   Mao GH, 2018, INT J BIOL MACROMOL, V107, P2211, DOI 10.1016/j.ijbiomac.2017.10.084
   Muhomah TA, 2019, BIOSCI MICROB FOOD H, V38, P55, DOI 10.12938/bmfh.18-027
   Pan YY, 2018, FOOD FUNCT, V9, P6269, DOI 10.1039/c8fo01116h
   Pan ZG, 2018, BIOCHEM BIOPH RES CO, V498, P416, DOI 10.1016/j.bbrc.2018.02.115
   Qi SW, 2017, HEPATOL RES, V47, P1484, DOI 10.1111/hepr.12876
   Ravishankar D, 2015, EUR J MED CHEM, V97, P259, DOI 10.1016/j.ejmech.2015.04.056
   Sanna S, 2019, NAT GENET, V51, P600, DOI 10.1038/s41588-019-0350-x
   Sharpe LJ, 2015, J NUTR SCI VITAMINOL, V61, pS154, DOI 10.3177/jnsv.61.S154
   Si MW, 2015, GENET MOL RES, V14, P9562, DOI 10.4238/2015.August.14.19
   Strzyz P., 2017, NAT REV MOL CELL BIO, V18, P227
   Takuya K., 2018, DRUG METAB PHARMACOK, V33, pS56
   Toplak H, 2016, WIEN KLIN WOCHENSCHR, V128, pS216, DOI 10.1007/s00508-016-0993-x
   Tung YC, 2018, FOOD FUNCT, V9, P3363, DOI [10.1039/c7fo02066j, 10.1039/C7FO02066J]
   Ushiroda C, 2019, J CLIN BIOCHEM NUTR, V65, P34, DOI 10.3164/jcbn.18-116
   Wang J, 2019, NUTR RES, V65, P63, DOI 10.1016/j.nutres.2019.02.004
   Wang W, 2019, FOOD SCI NUTR, V7, P2636, DOI 10.1002/fsn3.1118
   Wu T, 2018, FOOD FUNCT, V9, P2112, DOI 10.1039/c7fo02061a
   Wu YL, 2018, INT J BIOL MACROMOL, V118, P886, DOI 10.1016/j.ijbiomac.2018.06.140
   Xu H, 2016, J ENDOCRINOL, V229, P133, DOI 10.1530/JOE-15-0409
   Yin Y, 2017, BIOCHEM BIOPH RES CO, V482, P720, DOI 10.1016/j.bbrc.2016.11.101
   [喻青青 Yu Qingqing], 2018, [中草药, Chinese Traditional and Herbal Drugs], V49, P1092
   Zabielski P, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-25397-6
   Zarghani SS, 2018, ADV PHARM BULL, V8, P97, DOI 10.15171/apb.2018.012
   Zhang M, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-06542-z
   Zhang Y, 2019, LIVER INT, V39, P1207, DOI 10.1111/liv.14097
   Zhao LP, 2018, SCIENCE, V359, P1151, DOI 10.1126/science.aao5774
   Zheng F, 2019, LIPIDS HEALTH DIS, V18, DOI 10.1186/s12944-018-0933-z
   Zhou J, 2013, CIRC RES, V113, P40, DOI 10.1161/CIRCRESAHA.113.280883
   Zhu L, 2019, J CELL BIOCHEM, V120, P5777, DOI 10.1002/jcb.27864
NR 60
TC 18
Z9 18
U1 2
U2 51
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD NOV 1
PY 2020
VL 11
IS 11
BP 10033
EP 10046
DI 10.1039/d0fo01840f
PG 14
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA OV8ZL
UT WOS:000592490800055
PM 33135040
DA 2023-06-08
ER

PT J
AU Tilves, C
   Yeh, HC
   Maruthur, N
   Juraschek, SP
   Miller, ER
   Appel, LJ
   Mueller, NT
AF Tilves, Curtis
   Yeh, Hsin-Chieh
   Maruthur, Nisa
   Juraschek, Stephen P.
   Miller, Edgar R.
   Appel, Lawrence J.
   Mueller, Noel T.
TI A behavioral weight-loss intervention, but not metformin, decreases a
   marker of gut barrier permeability: results from the SPIRIT randomized
   trial
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Article
ID LIPOPOLYSACCHARIDE-BINDING PROTEIN; OBESITY; INFLAMMATION; INDIVIDUALS;
   EXPRESSION; MEDIATORS; ENDOTOXIN; DISEASE
AB BACKGROUND/OBJECTIVES: Lipopolysaccharide-binding protein (LBP), a biomarker of gut barrier permeability to lipopolysaccharides, is higher in adults with obesity and type 2 diabetes. Behavioral weight loss and metformin have distinct effects on the gut microbiome, but their impact on gut permeability to lipopolysaccharides is unknown. This study's objective was to determine the effects of a behavioral weight-loss intervention or metformin treatment on plasma LBP.
   SUBJECTS/METHODS: SPIRIT was a randomized trial of adults with overweight or obesity. Participants were randomized to one of three arms: metformin treatment, coach-directed behavioral weight loss on a DASH diet, or self-directed care (control). Of 121 participants, a random subset (n = 88) was selected to have LBP measured at baseline, 6 months, and 12 months post intervention. Intervention effects on LBP over time were assessed using generalized estimating equations (GEE). We also examined whether the intervention effects were modified by change in diet and weight.
   RESULTS: Arms were balanced by sex (83% female), race (51% white), and age (mean 60 years), with no differences in baseline LBP (median 4.23 mu g/mL). At 1 year, mean weight change was -3.00% in the metformin arm, -3.02% in the coach-directed behavioral weight-loss arm, and +0.33% in the self-directed (control) arm. The corresponding change in LBP was +1.03, -0.98, +1.03 mu g/mL. The behavioral weight-loss intervention reduced LBP compared to self-directed care (beta = -0.17, 95% CI: -0.33 to -0.01); no other between-arm comparisons were significant. Behavioral weight-loss participants who reduced dietary fat showed the greatest reductions in 6-month LBP (beta = -2.84, 95% CI: -5.17 to -0.50).
   CONCLUSIONS: Despite similar weight loss in the behavioral weight loss arm and the metformin arm, only the behavioral weight-loss intervention reduced LBP compared to control. Lifestyle weight-loss interventions that promote a DASH diet may be effective at reducing gut barrier permeability to lipopolysaccharides.
C1 [Tilves, Curtis; Mueller, Noel T.] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USA.
   [Tilves, Curtis; Yeh, Hsin-Chieh; Maruthur, Nisa; Miller, Edgar R.; Appel, Lawrence J.; Mueller, Noel T.] Johns Hopkins Univ, Welch Ctr Prevent Epidemiol & Clin Res, Baltimore, MD 21205 USA.
   [Juraschek, Stephen P.] Beth Israel Deaconess Med Ctr, Div Gen Med & Primary Care, Boston, MA USA.
C3 Johns Hopkins University; Johns Hopkins Bloomberg School of Public
   Health; Johns Hopkins University; Harvard University; Beth Israel
   Deaconess Medical Center
RP Mueller, NT (通讯作者)，Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USA.; Mueller, NT (通讯作者)，Johns Hopkins Univ, Welch Ctr Prevent Epidemiol & Clin Res, Baltimore, MD 21205 USA.
EM nmuelle4@jhu.edu
RI Appel, Larry/GLT-2608-2022
OI Mueller, Noel/0000-0002-7412-8352
FU Maryland Cigarette Restitution Fund; National Heart, Lung, and Blood
   Institute of the National Institutes of Health [K01HL141589]; National
   Cancer Institute's Cancer Centers Support Grant [5P30CA006973]; National
   Heart, Lung, and Blood Institute [T32HL007024]
FX The SPIRIT study was funded by the Maryland Cigarette Restitution Fund.
   NTM was supported by the National Heart, Lung, and Blood Institute of
   the National Institutes of Health (K01HL141589). HCY was supported in
   part by the National Cancer Institute's Cancer Centers Support Grant to
   the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
   (5P30CA006973). CT was supported by the National Heart, Lung, and Blood
   Institute grant T32HL007024.
CR Appel LJ, 2011, NEW ENGL J MED, V365, P1959, DOI 10.1056/NEJMoa1108660
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   Choi J, 2013, OBES REV, V14, P232, DOI 10.1111/obr.12003
   Clemente-Postigo M, 2015, SURG OBES RELAT DIS, V11, P933, DOI 10.1016/j.soard.2014.11.030
   Damms-Machado A, 2017, AM J CLIN NUTR, V105, P127, DOI 10.3945/ajcn.116.131110
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Fujimoto WY, 2007, DIABETES, V56, P1680, DOI 10.2337/db07-0009
   Gonzalez-Quintela A, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0054600
   Gonzalez-Sarrias A, 2018, MOL NUTR FOOD RES, V62, DOI 10.1002/mnfr.201800160
   GRUBE BJ, 1994, J BIOL CHEM, V269, P8477
   Han MS, 2020, P NATL ACAD SCI USA, V117, P2751, DOI 10.1073/pnas.1920004117
   Irimata K, 2018, P SAS GLOB FOR 2018
   Lepper PM, 2007, J AM COLL CARDIOL, V50, P25, DOI 10.1016/j.jacc.2007.02.070
   Liu X, 2014, DIABETOLOGIA, V57, P1834, DOI 10.1007/s00125-014-3288-7
   Moreno-Navarrete JM, 2013, DIABETOLOGIA, V56, P2524, DOI 10.1007/s00125-013-3015-9
   Marti A, 2021, NUTRIENTS, V13, DOI 10.3390/nu13020289
   Moreno-Navarrete JM, 2012, INT J OBESITY, V36, P1442, DOI 10.1038/ijo.2011.256
   Mueller NT, 2021, DIABETES CARE, V44, P1462, DOI 10.2337/dc20-2257
   Novitsky TJ, 1998, ANN NY ACAD SCI, V851, P416, DOI 10.1111/j.1749-6632.1998.tb09018.x
   Ott B, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-12109-9
   R Core Team, 2022, R LANG ENV STAT COMP
   Ruiz AG, 2007, OBES SURG, V17, P1374
   Salden BN, 2018, CLIN NUTR, V37, P471, DOI 10.1016/j.clnu.2017.01.024
   Scheller J, 2011, BBA-MOL CELL RES, V1813, P878, DOI 10.1016/j.bbamcr.2011.01.034
   Sonis ST, 2004, NAT REV CANCER, V4, P277, DOI 10.1038/nrc1318
   Van Amersfoort ES, 2003, CLIN MICROBIOL REV, V16, P379, DOI 10.1128/CMR.16.3.379-414.2003
   van Dielen FMH, 2004, J CLIN ENDOCR METAB, V89, P4062, DOI 10.1210/jc.2003-032125
   Wickham H., 2016, GGPLOT2 ELEGANT GRAP, DOI 10.1007/978-0-387-98141-3
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Wurfel MM, 1997, J EXP MED, V186, P2051, DOI 10.1084/jem.186.12.2051
   Yang PJ, 2014, SURG OBES RELAT DIS, V10, P1182, DOI 10.1016/j.soard.2014.02.022
   Yeh HC, 2021, J CLIN ENDOCR METAB, V106, pE4179, DOI 10.1210/clinem/dgab266
   Yerevanian A, 2019, CURR OBES REP, V8, P156, DOI 10.1007/s13679-019-00335-3
NR 33
TC 0
Z9 0
U1 1
U2 3
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0307-0565
EI 1476-5497
J9 INT J OBESITY
JI Int. J. Obes.
PD MAR
PY 2022
VL 46
IS 3
BP 655
EP 660
DI 10.1038/s41366-021-01039-2
EA JAN 2022
PG 6
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA ZI1ML
UT WOS:000739305100002
PM 34987204
OA Green Accepted
DA 2023-06-08
ER

PT J
AU Giron, F
   Quigley, EMM
AF Giron, Fanny
   Quigley, Eamonn M. M.
TI Pharmabiotic Manipulation of the Microbiota in Gastrointestinal
   Disorders: A Clinical Perspective
SO JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
LA English
DT Review
DE Anti-bacterial agents; Gastrointestinal microbiome; Prebiotics;
   Probiotics; Synbiotics
ID IRRITABLE-BOWEL-SYNDROME; INTESTINAL BACTERIAL OVERGROWTH;
   BIFIDOBACTERIUM-INFANTIS 35624; INTERNATIONAL SCIENTIFIC ASSOCIATION;
   GASTROESOPHAGEAL-REFLUX DISEASE; GUT MICROBIOTA; NONALCOHOLIC
   STEATOHEPATITIS; CONSENSUS STATEMENT; METFORMIN ALTERS; DOUBLE-BLIND
AB The advent and widespread availability of high-throughput technology has revolutionized the assessment of the communities of microorganisms that inhabit the gastrointestinal tract-the gut microbiota. As our understanding of the role of the microbiota in health and human disease increases, so also do efforts to prevent and treat disease through the modulation of the microbiota. Several strategies are available to us and range from time honored approaches, such as antibiotics and probiotics, to changes in diet, the administration of prebiotics as food supplements, and fecal microbiota transplantation. Of these, diet is perhaps the most pervasive but often ignored modulator of the microbiota, and a failure to recognize its impact complicates the interpretation of many microbiota studies. The impacts of antibiotics on the microbiota are more complex than originally thought and, though antibiotics can be life-saving, their effects on commensal bacterial populations can be clinically significant. Though there have been many studies of, and even more claims made for, probiotics, the majority of available studies suffer from significant deficits in study design and execution and many claims remain to be substantiated. Though holding much promise, the study of prebiotics in human disease is still in its infancy. Possibilities other than the administration of live organisms have been identified through efforts to mine the microbiota for novel therapeutics and include: dead organisms, bacterial components, small molecules elaborated by bacteria, and even bacterial DNA. Accordingly, the term pharmabiotic has been introduced to encompass the full range of therapeutic possibilities that the microbiota offers.
C1 Houston Methodist Hosp, Gastroenterol & Hepatol, Lynda K & David M Underwood Ctr Digest Disorders, Houston, TX 77030 USA.
   Weill Cornell Med Coll, Houston, TX USA.
C3 The Methodist Hospital System; The Methodist Hospital - Houston; Cornell
   University
RP Quigley, EMM (通讯作者)，Houston Methodist Hosp, Div Gastroenterol & Hepatol, 6550 Fannin St,SM1201, Houston, TX 77030 USA.
EM equigley@houstonmethodist.org
CR Abraham BP, 2017, GASTROENTEROL CLIN N, V46, P769, DOI 10.1016/j.gtc.2017.08.003
   Abu Shanab A, 2011, DIGEST DIS SCI, V56, P1524, DOI 10.1007/s10620-010-1447-3
   Altmann F, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0162983
   Amir I, 2014, ENVIRON MICROBIOL, V16, P2905, DOI 10.1111/1462-2920.12285
   Angulo P, 2015, GASTROENTEROLOGY, V149, P389, DOI 10.1053/j.gastro.2015.04.043
   Aziz Q, 2013, NEUROGASTROENT MOTIL, V25, P4, DOI 10.1111/nmo.12046
   Bauer PV, 2018, CELL METAB, V27, P101, DOI 10.1016/j.cmet.2017.09.019
   Bennet SMP, 2018, GUT, V67, P872, DOI 10.1136/gutjnl-2016-313128
   Blackett KL, 2013, ALIMENT PHARM THER, V37, P1084, DOI 10.1111/apt.12317
   Bouhnik Y, 1996, NUTR CANCER, V26, P21, DOI 10.1080/01635589609514459
   Britton RA, 2012, TRENDS MICROBIOL, V20, P313, DOI 10.1016/j.tim.2012.04.001
   Butaye P, 2003, CLIN MICROBIOL REV, V16, P175, DOI 10.1128/CMR.16.2.175-188.2003
   Charbonneau D, 2013, GUT MICROBES, V4, P201, DOI 10.4161/gmic.24196
   Cho I, 2012, NATURE, V488, P621, DOI 10.1038/nature11400
   Chumpitazi BP, 2015, ALIMENT PHARM THER, V42, P418, DOI 10.1111/apt.13286
   Claesson MJ, 2012, NATURE, V488, P178, DOI 10.1038/nature11319
   Clarke SF, 2014, GUT, V63, P1913, DOI 10.1136/gutjnl-2013-306541
   Collins J. Kevin, 2002, Microbial Ecology in Health and Disease, V14, P81, DOI 10.1080/08910600260081720
   Cook SI, 1998, ALIMENT PHARM THER, V12, P499, DOI 10.1046/j.1365-2036.1998.00337.x
   Corr SC, 2007, P NATL ACAD SCI USA, V104, P7617, DOI 10.1073/pnas.0700440104
   CUMMINGS JH, 1991, J APPL BACTERIOL, V70, P443, DOI 10.1111/j.1365-2672.1991.tb02739.x
   Davis LMG, 2010, INT J FOOD MICROBIOL, V144, P285, DOI 10.1016/j.ijfoodmicro.2010.10.007
   De Filippis Francesca, 2016, Gut, V65, P1812, DOI 10.1136/gutjnl-2015-309957
   De Palma G, 2014, J PHYSIOL-LONDON, V592, P2989, DOI 10.1113/jphysiol.2014.273995
   De Palma G, 2009, BRIT J NUTR, V102, P1154, DOI 10.1017/S0007114509371767
   Derwa Y, 2017, ALIMENT PHARM THER, V46, P389, DOI 10.1111/apt.14203
   Dethlefsen L, 2008, PLOS BIOL, V6, P2383, DOI 10.1371/journal.pbio.0060280
   Dunne C, 2001, AM J CLIN NUTR, V73, p386S, DOI 10.1093/ajcn/73.2.386s
   El-Serag HB, 2007, CLIN GASTROENTEROL H, V5, P17, DOI 10.1016/j.cgh.2006.09.016
   Endersen L, 2015, INT J FOOD MICROBIOL, V215, P79, DOI 10.1016/j.ijfoodmicro.2015.08.007
   Ford AC, 2014, AM J GASTROENTEROL, V109, P1547, DOI 10.1038/ajg.2014.202
   Freedberg DE, 2015, GASTROENTEROLOGY, V149, P883, DOI 10.1053/j.gastro.2015.06.043
   Fukui H, 2015, WORLD J HEPATOL, V7, P425, DOI 10.4254/wjh.v7.i3.425
   Galtier M, 2017, J CROHNS COLITIS, V11, P840, DOI 10.1093/ecco-jcc/jjw224
   Gatta L, 2017, ALIMENT PHARM THER, V45, P604, DOI 10.1111/apt.13928
   Ghoshal UC, 2017, INDIAN J GASTROENTER, V36, P390, DOI 10.1007/s12664-017-0797-6
   Ghoshal UC, 2016, EUR J GASTROEN HEPAT, V28, P281, DOI 10.1097/MEG.0000000000000557
   Ghoshal UC, 2014, WORLD J GASTROENTERO, V20, P2482, DOI 10.3748/wjg.v20.i10.2482
   Gibson GR, 2017, NAT REV GASTRO HEPAT, V14, P491, DOI 10.1038/nrgastro.2017.75
   Groeger D, 2013, GUT MICROBES, V4, P325, DOI 10.4161/gmic.25487
   Halmos EP, 2015, GUT, V64, P93, DOI 10.1136/gutjnl-2014-307264
   Halmos EP, 2014, GASTROENTEROLOGY, V146, P1830, DOI 10.1053/j.gastro.2014.04.034
   Harris JK, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0128346
   Hayashi Y, 2017, GASTROENTEROLOGY, V153, P521, DOI 10.1053/j.gastro.2017.04.020
   Hill C, 2014, NAT REV GASTRO HEPAT, V11, P506, DOI 10.1038/nrgastro.2014.66
   Holscher HD, 2017, GUT MICROBES, V8, P172, DOI 10.1080/19490976.2017.1290756
   Hungin APS, 2018, ALIMENT PHARM THER, V47, P1054, DOI 10.1111/apt.14539
   Jernberg C, 2007, ISME J, V1, P56, DOI 10.1038/ismej.2007.3
   Joyce SA, 2014, GUT MICROBES, V5, P669, DOI 10.4161/19490976.2014.969986
   Kang DJ, 2016, CLIN TRANSL GASTROEN, V7, DOI 10.1038/ctg.2016.44
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kimer N, 2014, ALIMENT PHARM THER, V40, P123, DOI 10.1111/apt.12803
   Klem F, 2017, GASTROENTEROLOGY, V152, P1042, DOI 10.1053/j.gastro.2016.12.039
   Konieczna P, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0062617
   Konieczna P, 2012, GUT MICROBES, V3, P261, DOI 10.4161/gmic.20358
   Konieczna P, 2012, GUT, V61, P354, DOI 10.1136/gutjnl-2011-300936
   Lawley TD, 2009, INFECT IMMUN, V77, P3661, DOI 10.1128/IAI.00558-09
   Lembo A, 2016, GASTROENTEROLOGY, V151, P1113, DOI 10.1053/j.gastro.2016.08.003
   Lievin-Le Moal V, 2016, THER ADV GASTROENTER, V9, P57, DOI 10.1177/1756283X15602831
   Liu HN, 2017, DIGEST LIVER DIS, V49, P331, DOI 10.1016/j.dld.2017.01.142
   London LEE, 2014, J NUTR, V144, P1956, DOI 10.3945/jn.114.191627
   Loomba R, 2017, CELL METAB, V25, P1054, DOI 10.1016/j.cmet.2017.04.001
   Lusiak-Szelachowska M, 2017, GUT PATHOG, V9, DOI 10.1186/s13099-017-0196-7
   Ma XC, 2007, J PHARMACOL EXP THER, V322, P391, DOI 10.1124/jpet.107.121913
   McIntosh K, 2017, GUT, V66, P1241, DOI 10.1136/gutjnl-2015-311339
   Merrigan MM, 2003, J INFECT DIS, V188, P1922, DOI 10.1086/379836
   Moayyedi P, 2014, AM J GASTROENTEROL, V109, P1367, DOI 10.1038/ajg.2014.195
   O'Mahony L, 2006, AM J PHYSIOL-GASTR L, V290, pG839, DOI 10.1152/ajpgi.00112.2005
   O'Mahony L, 2001, ALIMENT PHARM THER, V15, P1219, DOI 10.1046/j.1365-2036.2001.01027.x
   O'Sullivan O, 2013, J ANTIMICROB CHEMOTH, V68, P214, DOI 10.1093/jac/dks348
   Panigrahi P, 2017, NATURE, V548, P407, DOI 10.1038/nature23480
   Pimentel M, 2017, DIGEST DIS SCI, V62, P2455, DOI 10.1007/s10620-017-4598-7
   Pimentel M, 2011, NEW ENGL J MED, V364, P22, DOI 10.1056/NEJMoa1004409
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Quigley EMM, 2013, IRISH J MED SCI, V182, P1, DOI 10.1007/s11845-012-0865-y
   Quigley EM, 2015, SEMIN LIVER DIS, V35, P262, DOI 10.1055/s-0035-1562946
   Quigley EMM, 2017, NAT REV GASTRO HEPAT, V14, P315, DOI 10.1038/nrgastro.2017.29
   Quigley Eamonn M M, 2013, Gastroenterol Hepatol (N Y), V9, P560
   Quigley Eamonn M M, 2011, Gastroenterology, V141, P391, DOI 10.1053/j.gastro.2011.05.014
   Quigley EMM, 1996, DIGEST DIS SCI, V41, P557
   Rachmilewitz D, 2004, GASTROENTEROLOGY, V126, P520, DOI 10.1053/j.gastro.2003.11.019
   Rastall RA, 2015, CURR OPIN BIOTECH, V32, P42, DOI 10.1016/j.copbio.2014.11.002
   Rea MC, 2010, P NATL ACAD SCI USA, V107, P9352, DOI 10.1073/pnas.0913554107
   Ridlon JM, 2006, J LIPID RES, V47, P241, DOI 10.1194/jlr.R500013-JLR200
   Sambol SP, 2002, J INFECT DIS, V186, P1781, DOI 10.1086/345676
   Schiavi E, 2016, APPL ENVIRON MICROB, V82, P7185, DOI 10.1128/AEM.02238-16
   Scully P, 2013, CELL IMMUNOL, V281, P134, DOI 10.1016/j.cellimm.2013.03.008
   Shanahan F, 2014, GASTROENTEROLOGY, V146, P1554, DOI 10.1053/j.gastro.2014.01.050
   Shanahan F, 2010, GASTROENTEROL CLIN N, V39, P721, DOI 10.1016/j.gtc.2010.08.006
   Sharara AI, 2006, AM J GASTROENTEROL, V101, P326, DOI 10.1111/j.1572-0241.2006.00458.x
   Sibartie S, 2009, BMC IMMUNOL, V10, DOI 10.1186/1471-2172-10-54
   Staudacher HM, 2011, J HUM NUTR DIET, V24, P487, DOI 10.1111/j.1365-277X.2011.01162.x
   Staudacher HM, 2017, GASTROENTEROLOGY, V153, P936, DOI 10.1053/j.gastro.2017.06.010
   Sun ZH, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms9322
   Symonds EL, 2012, CLIN TRANSL GASTROEN, V3, DOI 10.1038/ctg.2012.9
   Tap J, 2017, GASTROENTEROLOGY, V152, P111, DOI 10.1053/j.gastro.2016.09.049
   Theocharidou E, 2017, GASTROENT RES PRACT, V2017, DOI 10.1155/2017/8270310
   Vandenbroucke K, 2010, MUCOSAL IMMUNOL, V3, P49, DOI 10.1038/mi.2009.116
   Vinogradov E, 2015, CARBOHYD RES, V413, P93, DOI 10.1016/j.carres.2015.06.001
   Wall R, 2014, ADV EXP MED BIOL, V817, P221, DOI 10.1007/978-1-4939-0897-4_10
   Wigg AJ, 2001, GUT, V48, P206, DOI 10.1136/gut.48.2.206
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Yang LY, 2012, CLIN CANCER RES, V18, P2138, DOI 10.1158/1078-0432.CCR-11-0934
   Yang LY, 2009, GASTROENTEROLOGY, V137, P588, DOI 10.1053/j.gastro.2009.04.046
   Zeber-Lubecka N, 2016, GUT MICROBES, V7, P397, DOI 10.1080/19490976.2016.1215805
   Zeevi D, 2015, CELL, V163, P1079, DOI 10.1016/j.cell.2015.11.001
   Zhao J, 2014, NEUROGASTROENT MOTIL, V26, P794, DOI 10.1111/nmo.12331
NR 107
TC 9
Z9 10
U1 1
U2 11
PU KOREAN SOC NEUROGASTROENTEROLOGY & MOTILITY
PI GANGNAM-GU
PA RM 305, LOTTE GOLD ROSE VILL II, 31 SEOLLEUNG-RO 86-GIL, GANGNAM-GU,
   SEOUL 135-839, SOUTH KOREA
SN 2093-0879
EI 2093-0887
J9 J NEUROGASTROENTEROL
JI J. Neurogastroenterol. Motil.
PD JUL
PY 2018
VL 24
IS 3
BP 355
EP 366
DI 10.5056/jnm18004
PG 12
WC Gastroenterology & Hepatology; Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Neurosciences & Neurology
GA GO1FZ
UT WOS:000439696400005
PM 29684976
OA Green Submitted, Green Published, gold
DA 2023-06-08
ER

PT J
AU Brunkwall, L
   Orho-Melander, M
AF Brunkwall, Louise
   Orho-Melander, Marju
TI The gut microbiome as a target for prevention and treatment of
   hyperglycaemia in type 2 diabetes: from current human evidence to future
   possibilities
SO DIABETOLOGIA
LA English
DT Review
DE 16S sequencing; Faecal microbiome; Genetics; Glycaemic control; Gut
   microbiome; Metagenomics; Metformin; Personalised nutrition; Probiotics;
   Review; Type 2 diabetes
ID GLUCOSE-METABOLISM; WIDE ASSOCIATION; DIET; METAGENOME; INCREASES;
   RICHNESS; BACTERIA; GENOME; IMPACT; OMICS
AB The totality of microbial genomes in the gut exceeds the size of the human genome, having around 500-fold more genes that importantly complement our coding potential. Microbial genes are essential for key metabolic processes, such as the breakdown of indigestible dietary fibres to short-chain fatty acids, biosynthesis of amino acids and vitamins, and production of neurotransmitters and hormones. During the last decade, evidence has accumulated to support a role for gut microbiota (analysed from faecal samples) in glycaemic control and type 2 diabetes. Mechanistic studies in mice support a causal role for gut microbiota in metabolic diseases, although human data favouring causality is insufficient. As it may be challenging to sort the human evidence from the large number of animal studies in the field, there is a need to provide a review of human studies. Thus, the aim of this review is to cover the current and future possibilities and challenges of using the gut microbiota, with its capacity to be modified, in the development of preventive and treatment strategies for hyperglycaemia and type 2 diabetes in humans. We discuss what is known about the composition and functionality of human gut microbiota in type 2 diabetes and summarise recent evidence of current treatment strategies that involve, or are based on, modification of gut microbiota (diet, probiotics, metformin and bariatric surgery). We go on to review some potential future gut-based glucose-lowering approaches involving microbiota, including the development of personalised nutrition and probiotic approaches, identification of therapeutic components of probiotics, targeted delivery of propionate in the proximal colon, targeted delivery of metformin in the lower gut, faecal microbiota transplantation, and the incorporation of genetically modified bacteria that express therapeutic factors into microbiota. Finally, future avenues and challenges for understanding the interplay between human nutrition, genetics and microbial genetics, and the need for integration of human multi-omic data (such as genetics, transcriptomics, epigenetics, proteomics and metabolomics) with microbiome data (such as strain-level variation, transcriptomics, proteomics and metabolomics) to make personalised treatments a successful future reality are discussed.
C1 [Brunkwall, Louise; Orho-Melander, Marju] Lund Univ, Dept Clin Sci Malmo, Ctr Diabet, Jan Waldenstroms Gata 35, S-20502 Malmo, Sweden.
C3 Lund University
RP Orho-Melander, M (通讯作者)，Lund Univ, Dept Clin Sci Malmo, Ctr Diabet, Jan Waldenstroms Gata 35, S-20502 Malmo, Sweden.
EM marju.orho-melander@med.lu.se
FU Swedish Research Council; Swedish Heart and Lung Foundation; Novo Nordic
   Foundation; Swedish Diabetes Foundation; Region Skane (Skane University
   Hospital); European Research Council [649021]; Novo Nordisk Fonden
   [NNF14OC0011049, NNF16OC0021370, NNF17OC0027348, NNF15OC0016320] Funding
   Source: researchfish
FX MO-M is a recipient of grants from the Swedish Research Council, the
   Swedish Heart and Lung Foundation, the Novo Nordic Foundation, the
   Swedish Diabetes Foundation, the Region Skane (Skane University
   Hospital) and the European Research Council (Consolidator grant no.
   649021, Orho-Melander).
CR Arora T, 2016, J INTERN MED, V280, P339, DOI 10.1111/joim.12508
   Bonder MJ, 2016, NAT GENET, V48, P1407, DOI 10.1038/ng.3663
   Braat H, 2006, CLIN GASTROENTEROL H, V4, P754, DOI 10.1016/j.cgh.2006.03.028
   Buse JB, 2016, DIABETES CARE, V39, P198, DOI 10.2337/dc15-0488
   Cani PD, 2007, DIABETOLOGIA, V50, P2374, DOI 10.1007/s00125-007-0791-0
   Chambers ES, 2015, GUT, V64, P1744, DOI 10.1136/gutjnl-2014-307913
   Chen ZY, 2014, J CLIN INVEST, V124, P3391, DOI 10.1172/JCI72517
   Dao MC, 2016, GUT, V65, P426, DOI 10.1136/gutjnl-2014-308778
   Davenport ER, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0140301
   David LA, 2014, NATURE, V505, P559, DOI 10.1038/nature12820
   De Filippo C, 2010, P NATL ACAD SCI USA, V107, P14691, DOI 10.1073/pnas.1005963107
   DeFronzo RA, 2016, DIABETOLOGIA, V59, P1645, DOI 10.1007/s00125-016-3992-6
   Evers SS, 2017, ANNU REV PHYSIOL, V79, P313, DOI 10.1146/annurev-physiol-022516-034423
   Falony G, 2016, SCIENCE, V352, P560, DOI 10.1126/science.aad3503
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Franzosa EA, 2015, NAT REV MICROBIOL, V13, P360, DOI 10.1038/nrmicro3451
   Gall WE, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0010883
   Goodman AL, 2011, P NATL ACAD SCI USA, V108, P6252, DOI 10.1073/pnas.1102938108
   Goodrich JK, 2016, CELL HOST MICROBE, V19, P731, DOI 10.1016/j.chom.2016.04.017
   Goodrich JK, 2014, CELL, V159, P789, DOI 10.1016/j.cell.2014.09.053
   Goodrich JK, 2014, CELL, V158, P250, DOI 10.1016/j.cell.2014.06.037
   Healey G, 2016, BMJ OPEN, V6, DOI 10.1136/bmjopen-2016-012504
   Jovel J, 2016, FRONT MICROBIOL, V7, DOI 10.3389/fmicb.2016.00459
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kaska L, 2016, WORLD J GASTROENTERO, V22, P8698, DOI 10.3748/wjg.v22.i39.8698
   Khoruts A, 2016, NAT REV GASTRO HEPAT, V13, DOI 10.1038/nrgastro.2016.98
   Korpela K, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0090702
   Kovatcheva-Datchary P, 2015, CELL METAB, V22, P971, DOI 10.1016/j.cmet.2015.10.001
   Lampe JW, 2013, P NUTR SOC, V72, P207, DOI 10.1017/S0029665113000025
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Le Chatelier E, 2013, NATURE, V500, P541, DOI 10.1038/nature12506
   Li JH, 2014, NAT BIOTECHNOL, V32, P834, DOI 10.1038/nbt.2942
   Martinez I, 2013, ISME J, V7, P269, DOI 10.1038/ismej.2012.104
   Napolitano A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100778
   Pedersen HK, 2016, NATURE, V535, P376, DOI 10.1038/nature18646
   Pingitore A, 2017, DIABETES OBES METAB, V19, P257, DOI 10.1111/dom.12811
   Plovier H, 2017, NAT MED, V23, P107, DOI 10.1038/nm.4236
   Power RA, 2017, NAT REV GENET, V18, P41, DOI 10.1038/nrg.2016.132
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Salonen A, 2014, ISME J, V8, P2218, DOI 10.1038/ismej.2014.63
   Sekar S, 2011, J DIABETES COMPLICAT, V25, P187, DOI 10.1016/j.jdiacomp.2010.07.003
   Sonnenburg ED, 2014, CELL METAB, V20, P779, DOI 10.1016/j.cmet.2014.07.003
   Tap J, 2015, ENVIRON MICROBIOL, V17, P4954, DOI 10.1111/1462-2920.13006
   Tremaroli V, 2015, CELL METAB, V22, P228, DOI 10.1016/j.cmet.2015.07.009
   Turpin W, 2016, NAT GENET, V48, P1413, DOI 10.1038/ng.3693
   Vrieze A, 2012, GASTROENTEROLOGY, V143, P913, DOI 10.1053/j.gastro.2012.06.031
   Wang TJ, 2011, NAT MED, V17, P448, DOI 10.1038/nm.2307
   Yassour M, 2016, GENOME MED, V8, DOI 10.1186/s13073-016-0271-6
   Zhang L, 2016, ISME J, V11, P676
   Zhang XY, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0071108
   Zhernakova A, 2016, SCIENCE, V352, P565, DOI 10.1126/science.aad3369
NR 51
TC 217
Z9 237
U1 20
U2 259
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0012-186X
EI 1432-0428
J9 DIABETOLOGIA
JI Diabetologia
PD JUN
PY 2017
VL 60
IS 6
BP 943
EP 951
DI 10.1007/s00125-017-4278-3
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EU4JK
UT WOS:000400995400001
PM 28434033
OA hybrid, Green Published
HC Y
HP N
DA 2023-06-08
ER

PT J
AU Mrozinska, S
   Radkowski, P
   Gosiewski, T
   Szopa, M
   Bulanda, M
   Ludwig-Galezowska, AH
   Morawska, I
   Sroka-Oleksiak, A
   Matejko, B
   Kapusta, P
   Salamon, D
   Malecki, MT
   Wolkow, P
   Klupa, T
AF Mrozinska, Sandra
   Radkowski, Piotr
   Gosiewski, Tomasz
   Szopa, Magdalena
   Bulanda, Malgorzata
   Ludwig-Galezowska, Agnieszka H.
   Morawska, Iwona
   Sroka-Oleksiak, Agnieszka
   Matejko, Bartlomiej
   Kapusta, Przemyslaw
   Salamon, Dominika
   Malecki, Maciej T.
   Wolkow, Pawel
   Klupa, Tomasz
TI Qualitative Parameters of the Colonic Flora in Patients with HNF1A-MODY
   Are Different from Those Observed in Type 2 Diabetes Mellitus
SO JOURNAL OF DIABETES RESEARCH
LA English
DT Article
ID GUT MICROBIOTA; AKKERMANSIA-MUCINIPHILA; PEPTIDE-1 SECRETION; YOUNG
   MODY; METAGENOME; DIVERSITY; METFORMIN; BUTYRATE; GLUCOSE; HEALTH
AB Background. Type 2 diabetes mellitus (T2DM) is determined by genetic and environmental factors. There have been many studies on the relationship between the composition of the gastrointestinal bacterial flora, T2DM, and obesity. There are no data, however, on the gut microbiome structure in monogenic forms of the disease including Maturity Onset Diabetes of the Young (MODY). Methods. The aim of the investigation was to compare the qualitative parameters of the colonic flora in patients with HNF1A-MODY and T2DM and healthy individuals. 16S sequencing of bacterial DNA isolated from the collected fecal samples using the MiSeq platform was performed. Results. There were significant between-group differences in the bacterial profile. At the phylum level, the amount of Proteobacteria was higher (p = 0.0006) and the amount of Bacteroidetes was lower (p = 0.0005) in T2DM group in comparison to the control group. In HNF1A-MODY group, the frequency of Bacteroidetes was lower than in the control group (p = 0.0143). At the order level, Turicibacterales was more abundant in HNF1A-MODY group than in T2DM group. Conclusions. It appears that there are differences in the gut microbiome composition between patients with HNF1A-MODY and type 2 diabetes. Further investigation on this matter should be conducted.
C1 [Mrozinska, Sandra; Szopa, Magdalena; Ludwig-Galezowska, Agnieszka H.; Morawska, Iwona; Matejko, Bartlomiej; Malecki, Maciej T.; Klupa, Tomasz] Jagiellonian Univ, Coll Med, Dept Metab Dis, 15 Kopernika St, PL-31501 Krakow, Poland.
   [Mrozinska, Sandra; Szopa, Magdalena; Morawska, Iwona; Malecki, Maciej T.; Klupa, Tomasz] Univ Hosp, 36 Kopernika St, PL-31501 Krakow, Poland.
   [Radkowski, Piotr; Ludwig-Galezowska, Agnieszka H.; Kapusta, Przemyslaw; Wolkow, Pawel] Jagiellonian Univ, Coll Med, Ctr Med Genom OMICRON, 7c Kopernika St, PL-31034 Krakow, Poland.
   [Gosiewski, Tomasz; Bulanda, Malgorzata; Sroka-Oleksiak, Agnieszka; Salamon, Dominika] Jagiellonian Univ, Coll Med, Dept Microbiol, 18 Czysta St, PL-31121 Krakow, Poland.
C3 Jagiellonian University; Collegium Medicum Jagiellonian University;
   Jagiellonian University; Collegium Medicum Jagiellonian University;
   Jagiellonian University; Collegium Medicum Jagiellonian University;
   Jagiellonian University; Collegium Medicum Jagiellonian University
RP Klupa, T (通讯作者)，Jagiellonian Univ, Coll Med, Dept Metab Dis, 15 Kopernika St, PL-31501 Krakow, Poland.; Klupa, T (通讯作者)，Univ Hosp, 36 Kopernika St, PL-31501 Krakow, Poland.
EM tomasz.klupa@uj.edu.pl
RI Szopa, Magdalena/AAI-7193-2020; Wolkow, Pawel/AAI-4222-2021; Matejko,
   Bartlomiej/AFK-4579-2022; Salamon, Dominika/ADX-9625-2022; Gosiewski,
   Tomasz/ABI-5869-2020; Sroka-Oleksiak, Agnieszka/GRS-2686-2022; Matejko,
   Bartlomiej/K-2280-2014; Gosiewski, Tomasz/GSN-5166-2022; Matejko,
   Bartlomiej/AAG-3279-2022; Matejko, Bartlomiej/GQO-9967-2022; Klupa,
   Tomasz/V-9559-2019; Gosiewski, Tomasz/U-3349-2018; Sroka-Oleksiak,
   Agnieszka/GRE-8475-2022
OI Wolkow, Pawel/0000-0002-9322-5545; Gosiewski,
   Tomasz/0000-0003-4725-5943; Gosiewski, Tomasz/0000-0003-4725-5943;
   Matejko, Bartlomiej/0000-0001-6938-352X; Matejko,
   Bartlomiej/0000-0001-6938-352X; Gosiewski, Tomasz/0000-0003-4725-5943;
   Sroka-Oleksiak, Agnieszka/0000-0003-4998-279X; Ludwig-Slomczynska,
   Agnieszka H./0000-0002-0548-4767; Kapusta,
   Przemyslaw/0000-0003-4467-1175
FU European Union from the European Regional Development Fund; National
   Science Centre in Poland [DEC-2011/03/D/NZ5/00551]; EFSD New Horizons
   Programme award
FX The authors would like to thank all the patients and their families for
   taking part in the study. The study was performed as part of the project
   entitled the Influence of the Dipeptidyl Peptidase-4 Inhibitors on the
   Quantitative and Qualitative Analyses of the Intestinal Bacterial Flora
   in Patients with Type 2 Diabetes and in Patients with HNF1A Diabetes
   which is cofinanced by the European Union from the European Regional
   Development Fund. The control group was collected and examined in the
   framework of the project supported by the National Science Centre in
   Poland no. DEC-2011/03/D/NZ5/00551. The study was also supported by an
   EFSD New Horizons Programme award.
CR Amer Diabet Assoc, 2013, DIABETES CARE, V36, P1033, DOI 10.2337/dc12-2625
   Bartram AK, 2011, APPL ENVIRON MICROB, V77, P3846, DOI 10.1128/AEM.02772-10
   Belzer C, 2012, ISME J, V6, P1449, DOI 10.1038/ismej.2012.6
   Brethauer SA, 2013, ANN SURG, V258, P628, DOI 10.1097/SLA.0b013e3182a5034b
   Chimerel C, 2014, CELL REP, V9, P1202, DOI 10.1016/j.celrep.2014.10.032
   Choi BCK, 2001, DIABETOLOGIA, V44, P1221, DOI 10.1007/s001250100648
   Claesson MJ, 2012, NATURE, V488, P178, DOI 10.1038/nature11319
   Dao MC, 2016, GUT, V65, P426, DOI 10.1136/gutjnl-2014-308778
   Derrien M, 2008, APPL ENVIRON MICROB, V74, P1646, DOI 10.1128/AEM.01226-07
   Devkota S, 2016, SCIENCE, V351, P452, DOI 10.1126/science.aaf1353
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Fletcher Barbara, 2002, J Cardiovasc Nurs, V16, P17
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Freeland KR, 2010, BRIT J NUTR, V103, P82, DOI 10.1017/S0007114509991462
   Freeman H, 2006, HUM MOL GENET, V15, pR202, DOI 10.1093/hmg/ddl191
   Gao ZG, 2009, DIABETES, V58, P1509, DOI 10.2337/db08-1637
   GIBSON GR, 1995, J NUTR, V125, P1401, DOI 10.1093/jn/125.6.1401
   International Diabetes Federation, 2014, IDF DIABETES ATLAS
   Isomaa B, 1998, DIABETOLOGIA, V41, P467, DOI 10.1007/s001250050931
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Khan S, 2015, EPIGENOMICS-UK, V7, P669, DOI [10.2217/EPI.15.20, 10.2217/epi.15.20]
   Klaassen CD, 2015, DRUG METAB DISPOS, V43, P1505, DOI 10.1124/dmd.115.065698
   Lambeth Stacey M, 2015, J Diabetes Obes, V2, P1
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Le Chatelier E, 2013, NATURE, V500, P541, DOI 10.1038/nature12506
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Ley RE, 2006, NATURE, V444, P1022, DOI 10.1038/4441022a
   Lozupone CA, 2012, NATURE, V489, P220, DOI 10.1038/nature11550
   Lyssenko V, 2013, DIABETES CARE, V36, pS120, DOI 10.2337/dcS13-2009
   Manolio TA, 2009, NATURE, V461, P747, DOI 10.1038/nature08494
   Mariat D, 2009, BMC MICROBIOL, V9, DOI 10.1186/1471-2180-9-123
   Patti ME, 2009, OBESITY, V17, P1671, DOI 10.1038/oby.2009.102
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Ryan KK, 2014, NATURE, V509, P183, DOI 10.1038/nature13135
   Shields BM, 2010, DIABETOLOGIA, V53, P2504, DOI 10.1007/s00125-010-1799-4
   Subramanian Savitha, 2014, Diabetes Spectr, V27, P87, DOI 10.2337/diaspect.27.2.87
   Tolhurst G, 2012, DIABETES, V61, P364, DOI 10.2337/db11-1019
   Turnbaugh PJ, 2009, NATURE, V457, P480, DOI 10.1038/nature07540
   Wheeler BJ, 2013, J DIABETES METAB DIS, V12, DOI 10.1186/2251-6581-12-46
   Xu JY, 2005, EUR J HUM GENET, V13, P422, DOI 10.1038/sj.ejhg.5201347
NR 40
TC 10
Z9 10
U1 0
U2 8
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6745
EI 2314-6753
J9 J DIABETES RES
JI J. Diabetes Res.
PY 2016
VL 2016
AR 3876764
DI 10.1155/2016/3876764
PG 9
WC Endocrinology & Metabolism; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Research & Experimental Medicine
GA EA0NO
UT WOS:000386284300001
OA Green Published, Green Submitted, gold
DA 2023-06-08
ER

PT J
AU Olivier, S
   Pochard, C
   Diounou, H
   Castillo, V
   Divoux, J
   Alcantara, J
   Leclerc, J
   Guilmeau, S
   Huet, C
   Charifi, W
   Varin, TV
   Daniel, N
   Foretz, M
   Neunlist, M
   Salomon, BL
   Ghosh, P
   Marette, A
   Rolli-Derkinderen, M
   Viollet, B
AF Olivier, Severine
   Pochard, Camille
   Diounou, Hanna
   Castillo, Vanessa
   Divoux, Jordane
   Alcantara, Joshua
   Leclerc, Jocelyne
   Guilmeau, Sandra
   Huet, Camille
   Charifi, Wafa
   Varin, Thibault V.
   Daniel, Noemie
   Foretz, Marc
   Neunlist, Michel
   Salomon, Benoit L.
   Ghosh, Pradipta
   Marette, Andre
   Rolli-Derkinderen, Malvyne
   Viollet, Benoit
TI Deletion of intestinal epithelial AMP-activated protein kinase alters
   distal colon permeability but not glucose homeostasis
SO MOLECULAR METABOLISM
LA English
DT Article
DE AMPK; Intestinal epithelial barrier (IEB); Permeability; Microbiota;
   Obesity; Metformin
ID DIET-INDUCED OBESITY; HIGH-FAT DIET; BARRIER FUNCTION; GUT MICROBIOTA;
   INFLAMMATION; HEALTH; MICE; PHYSIOLOGY; EXPRESSION; COLITIS
AB Objective: The intestinal epithelial barrier (IEB) restricts the passage of microbes and potentially harmful substances from the lumen through the paracellular space, and rupture of its integrity is associated with a variety of gastrointestinal disorders and extra-digestive diseases. Increased IEB permeability has been linked to disruption of metabolic homeostasis leading to obesity and type 2 diabetes. Interestingly, recent studies have uncovered compelling evidence that the AMP-activated protein kinase (AMPK) signaling pathway plays an important role in maintaining epithelial cell barrier function. However, our understanding of the function of intestinal AMPK in regulating IEB and glucose homeostasis remains sparse.
   Methods: We generated mice lacking the two a1 and a2 AMPK catalytic subunits specifically in intestinal epithelial cells (IEC AMPK KO) and determined the physiological consequences of intestinal-specific deletion of AMPK in response to high-fat diet (HFD)-induced obesity. We combined histological, functional, and integrative analyses to ascertain the effects of gut AMPK loss on intestinal permeability in vivo and ex vivo and on the development of obesity and metabolic dysfunction. We also determined the impact of intestinal AMPK deletion in an inducible mouse model (i-IEC AMPK KO) by measuring IEB function, glucose homeostasis, and the composition of gut microbiota via fecal 16S rRNA sequencing.
   Results: While there were no differences in in vivo intestinal permeability in WT and IEC AMPK KO mice, ex vivo transcellular and paracellular permeability measured in Ussing chambers was significantly increased in the distal colon of IEC AMPK KO mice. This was associated with a reduction in pSer425 GIV phosphorylation, a marker of leaky gut barrier. However, the expression of tight junction proteins in intestinal epithelial cells and pro-inflammatory cytokines in the lamina propria were not different between genotypes. Although the HFD-fed AMPK KO mice displayed suppression of the stress polarity signaling pathway and a concomitant increase in colon permeability, loss of intestinal AMPK did not exacerbate body weight gain or adiposity. Deletion of AMPK was also not sufficient to alter glucose homeostasis or the acute glucose-lowering action of metformin in control diet (CD)- or HFD-fed mice. CD-fed i-IEC AMPK KO mice also presented higher permeability in the distal colon under homeostatic conditions but, surprisingly, this was not detected upon HFD feeding. Alteration in epithelial barrier function in the i-IEC AMPK KO mice was associated with a shift in the gut microbiota composition with higher levels of Clostridiales and Desulfovibrionales.
   Conclusions: Altogether, our results revealed a significant role of intestinal AMPK in maintaining IEB integrity in the distal colon but not in regulating glucose homeostasis. Our data also highlight the complex interaction between gut microbiota and host AMPK.
   m 2021 The Author(s). Published by Elsevier GmbH. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
C1 [Olivier, Severine; Diounou, Hanna; Leclerc, Jocelyne; Guilmeau, Sandra; Huet, Camille; Charifi, Wafa; Foretz, Marc; Viollet, Benoit] Univ Paris, Inst Cochin, CNRS, INSERM, F-75014 Paris, France.
   [Pochard, Camille; Neunlist, Michel; Rolli-Derkinderen, Malvyne] Univ Nantes, IMAD, TENS, INSERM,Enter Nervous Syst Gut & Brain Dis, Nantes, France.
   [Castillo, Vanessa; Alcantara, Joshua; Ghosh, Pradipta] Univ Calif San Diego, Dept Cellular & Mol Med, La Jolla, CA 92093 USA.
   [Divoux, Jordane; Salomon, Benoit L.] Sorbonne Univ, Ctr Immunol & Malad Infect CIMI, CNRS, INSERM, Paris, France.
   [Varin, Thibault V.; Daniel, Noemie; Marette, Andre] Laval Univ Quebec, Quebec Heart & Lung Res Inst IUCPQ, Quebec City, PQ, Canada.
   [Varin, Thibault V.; Daniel, Noemie; Marette, Andre] Laval Univ Quebec, Inst Nutr & Funct Foods INAF, Quebec City, PQ, Canada.
   [Ghosh, Pradipta] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA.
C3 Centre National de la Recherche Scientifique (CNRS); Institut National
   de la Sante et de la Recherche Medicale (Inserm); UDICE-French Research
   Universities; Universite Paris Cite; Institut National de la Sante et de
   la Recherche Medicale (Inserm); Nantes Universite; University of
   California System; University of California San Diego; Centre National
   de la Recherche Scientifique (CNRS); Institut National de la Sante et de
   la Recherche Medicale (Inserm); UDICE-French Research Universities;
   Sorbonne Universite; Laval University; Laval University; University of
   California System; University of California San Diego
RP Viollet, B (通讯作者)，Inst Cochin, 24 Rue Faubourg St Jacques, F-75014 Paris, France.; Rolli-Derkinderen, M (通讯作者)，Fac Med, TENS, 1 Rue Gaston Veil, F-44035 Nantes 1, France.
EM malvyne.derkinderen@univ-nantes.fr; benoit.viollet@inserm.fr
RI Viollet, Benoit/O-6927-2017; Viollet, Benoit/N-2397-2019; Salomon,
   Benoit/M-2421-2017; FORETZ, Marc/O-7334-2017
OI Viollet, Benoit/0000-0002-0121-0224; Viollet,
   Benoit/0000-0002-0121-0224; Castillo, Vanessa/0000-0002-4182-8846;
   Salomon, Benoit/0000-0001-9673-5578; Daniel, Noemie/0000-0003-4319-0054;
   FORETZ, Marc/0000-0001-7017-9032; Alcantara, Joshua/0000-0002-7970-8970;
   Diounou, Hanna/0000-0002-0052-5435
FU Inserm, CNRS, Universite de Paris Descartes; Region Ile-de-France;
   Agence Nationale de la Recherche [ANR-17-CE15-0030,
   ANR-19-CE14-0023-01]; Societe Francophone du Diabete; Region
   Ile-de-France (CORDDIM); National Institutes of Health [CA238042,
   AI141630, CA100768]; Canadian Institutes for Heart Research (CIHR)
   [FDN-143247]; Pfizer/CIHR research Chair in the pathogenesis of insulin
   resistance and cardiovascular diseases
FX These studies were supported by grants from Inserm, CNRS, Universite de
   Paris Descartes, Region Ile-de-France, Agence Nationale de la Recherche
   (ANR-17-CE15-0030 and ANR-19-CE14-0023-01), and Societe Francophone du
   Diabete (allocation de recherche SFD-Industrie 2016 Pierre Fabre
   Medicament). S.O. holds a doctoral fellowship from Region Ile-de-France
   (CORDDIM). P.G., J.A., and V.C. were supported by the National
   Institutes of Health (CA238042, AI141630, and CA100768 to P.G). Work was
   also partly funded by the Canadian Institutes for Heart Research (CIHR)
   to A.M. (FDN-143247). A.M. was the recipient of a Pfizer/CIHR research
   Chair in the pathogenesis of insulin resistance and cardiovascular
   diseases.
CR Amouyal C, 2020, EBIOMEDICINE, V58, DOI 10.1016/j.ebiom.2020.102895
   Anhe FF, 2019, GUT, V68, P453, DOI 10.1136/gutjnl-2017-315565
   Araujo JR, 2020, CELL HOST MICROBE, V27, P358, DOI 10.1016/j.chom.2020.01.028
   Araujo JR, 2017, BIOCHIMIE, V141, P97, DOI 10.1016/j.biochi.2017.05.019
   Aznar N, 2016, ELIFE, V5, DOI 10.7554/eLife.20795
   Backhed F, 2007, P NATL ACAD SCI USA, V104, P979, DOI 10.1073/pnas.0605374104
   Bibi S, 2018, J NUTR BIOCHEM, V51, P40, DOI 10.1016/j.jnutbio.2017.08.017
   Boudaba N, 2018, EBIOMEDICINE, V28, P194, DOI 10.1016/j.ebiom.2018.01.008
   Callahan BJ, 2016, NAT METHODS, V13, P581, DOI [10.1038/NMETH.3869, 10.1038/nmeth.3869]
   Cani PD, 2009, GUT, V58, P1091, DOI 10.1136/gut.2008.165886
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   Cani PD, 2019, NAT REV ENDOCRINOL, V15, P69, DOI 10.1038/s41574-018-0143-9
   Cao ST, 2020, FREE RADICAL BIO MED, V147, P8, DOI 10.1016/j.freeradbiomed.2019.12.004
   Carvalho BM, 2012, DIABETOLOGIA, V55, P2823, DOI 10.1007/s00125-012-2648-4
   Chang J, 2017, GASTROENTEROLOGY, V153, P723, DOI 10.1053/j.gastro.2017.05.056
   Chang KW, 2015, FOOD FUNCT, V6, P3334, DOI [10.1039/C5FO00513B, 10.1039/c5fo00513b]
   Chassaing B, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0044328
   Damms-Machado A, 2017, AM J CLIN NUTR, V105, P127, DOI 10.3945/ajcn.116.131110
   De Quelen F, 2011, J PHYSIOL-LONDON, V589, P4341, DOI 10.1113/jphysiol.2011.214056
   Depommier C, 2019, NAT MED, V25, P1096, DOI 10.1038/s41591-019-0495-2
   Donohoe DR, 2011, CELL METAB, V13, P517, DOI 10.1016/j.cmet.2011.02.018
   Dosoky NS, 2020, APPL MICROBIOL BIOT, V104, P7657, DOI 10.1007/s00253-020-10771-0
   Duca FA, 2015, NAT MED, V21, P506, DOI 10.1038/nm.3787
   Ducommun S, 2015, CELL SIGNAL, V27, P978, DOI 10.1016/j.cellsig.2015.02.008
   Dusaulcy R., 2016, ENDOCRINOLOGY, V157
   El Marjou F, 2004, GENESIS, V39, P186, DOI 10.1002/gene.20042
   Elamin E.E., 2013, J NUTR, V143
   Elamin E, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0035008
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Evers SS, 2017, ANNU REV PHYSIOL, V79, P313, DOI 10.1146/annurev-physiol-022516-034423
   Foretz M, 2019, NAT REV ENDOCRINOL, V15, P569, DOI 10.1038/s41574-019-0242-2
   Gai L, 2019, MED SCI MONITOR, V25, P10045, DOI 10.12659/MSM.918935
   Genser L, 2018, J PATHOL, V246, P217, DOI 10.1002/path.5134
   Ghosh P, 2020, LIFE SCI ALLIANCE, V3, DOI 10.26508/lsa.201900481
   Ghosh P, 2017, AGING-US, V9, P303, DOI 10.18632/aging.101179
   Guilmeau S, 2008, GASTROENTEROLOGY, V135, P849, DOI 10.1053/j.gastro.2008.05.050
   Hakansson A, 2015, CLIN EXP MED, V15, P107, DOI 10.1007/s10238-013-0270-5
   Hardie DG, 2014, ANNU REV NUTR, V34, P31, DOI 10.1146/annurev-nutr-071812-161148
   Hardie David Grahame, 2017, F1000Res, V6, P1724, DOI 10.12688/f1000research.11960.1
   Harmel E, 2014, ENDOCRINOLOGY, V155, P873, DOI 10.1210/en.2013-1750
   Hiel S., 2020, CLIN NUTR
   Hiippala K, 2018, NUTRIENTS, V10, DOI 10.3390/nu10080988
   Johnson AMF, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0122195
   Krumbeck JA, 2018, MICROBIOME, V6, DOI 10.1186/s40168-018-0494-4
   Lassenius MI, 2011, DIABETES CARE, V34, P1809, DOI 10.2337/dc10-2197
   Leech B, 2019, INT J CLIN PRACT, V73, DOI 10.1111/ijcp.13385
   Li Q, 2020, J FOOD BIOCHEM, V44, DOI 10.1111/jfbc.13123
   Li Q, 2019, FOOD FUNCT, V10, P7174, DOI 10.1039/c9fo01465a
   Lieberthal W, 2013, BMC NEPHROL, V14, DOI 10.1186/1471-2369-14-251
   Lynch SV, 2016, NEW ENGL J MED, V375, P2369, DOI 10.1056/NEJMra1600266
   Mariadason JM, 2005, GASTROENTEROLOGY, V128, P1081, DOI 10.1053/j.gastro.2005.01.054
   Mellman I., 2011, J BIOL CHEM, V286
   Moor AE, 2018, CELL, V175, P1156, DOI 10.1016/j.cell.2018.08.063
   Odenwald MA, 2013, CLIN GASTROENTEROL H, V11, P1075, DOI 10.1016/j.cgh.2013.07.001
   Ohlsson B, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18030582
   Olivier S, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20205171
   Park HY, 2015, BIOSCI BIOTECH BIOCH, V79, P130, DOI 10.1080/09168451.2014.951027
   Peng LY, 2009, J NUTR, V139, P1619, DOI 10.3945/jn.109.104638
   Postler TS, 2017, CELL METAB, V26, P110, DOI 10.1016/j.cmet.2017.05.008
   Quast C, 2013, NUCLEIC ACIDS RES, V41, pD590, DOI 10.1093/nar/gks1219
   Rowan F, 2010, DIS COLON RECTUM, V53, P1530, DOI 10.1007/DCR.0b013e3181f1e620
   Ryu S.H., 2020, CELL METAB
   Sayers SR, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0149549
   Scharl M, 2009, J BIOL CHEM, V284, P27952, DOI 10.1074/jbc.M109.046292
   Segata N, 2011, GENOME BIOL, V12, DOI 10.1186/gb-2011-12-6-r60
   Sonnenburg JL, 2016, NATURE, V535, P56, DOI 10.1038/nature18846
   Sun X., 2018, MOL NUTR FOOD RES, V62
   Sun XF, 2017, CELL DEATH DIFFER, V24, P819, DOI 10.1038/cdd.2017.14
   Tilg H, 2020, NAT REV IMMUNOL, V20, P40, DOI 10.1038/s41577-019-0198-4
   Turner JR, 2009, NAT REV IMMUNOL, V9, P799, DOI 10.1038/nri2653
   Viollet B, 2003, J CLIN INVEST, V111, P91, DOI 10.1172/JCI200316567
   Vivinus-Nebot M, 2014, GUT, V63, P744, DOI 10.1136/gutjnl-2012-304066
   Waise TMZ, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-08582-7
   Wang B, 2016, J NUTR, V146, P501, DOI 10.3945/jn.115.224857
   Wang Q, 2007, APPL ENVIRON MICROB, V73, P5261, DOI 10.1128/AEM.00062-07
   Wei W., 2017, BIOMED PHARMACOTHER, V94
   Wongkrasant P, 2020, BIOMED PHARMACOTHER, V129, DOI 10.1016/j.biopha.2020.110415
   Wu WC, 2020, FASEB J, V34, P4852, DOI 10.1096/fj.201901994R
   Wu WC, 2018, MOL PHARMACEUT, V15, P3272, DOI 10.1021/acs.molpharmaceut.8b00332
   WYATT J, 1993, LANCET, V341, P1437, DOI 10.1016/0140-6736(93)90882-H
   Xiang RL, 2014, J MOL CELL BIOL, V6, P486, DOI 10.1093/jmcb/mju048
   Yano T, 2013, J CELL BIOL, V203, P605, DOI 10.1083/jcb.201304194
   Zhang L, 2006, P NATL ACAD SCI USA, V103, P17272, DOI 10.1073/pnas.0608531103
   Zheng B, 2007, P NATL ACAD SCI USA, V104, P819, DOI 10.1073/pnas.0610157104
   Zhou K, 2018, PHYTOMEDICINE, V46, P46, DOI 10.1016/j.phymed.2018.04.033
   Zhu MJ, 2018, TISSUE BARRIERS, V6, DOI 10.1080/21688370.2018.1487249
NR 87
TC 14
Z9 16
U1 2
U2 9
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2212-8778
J9 MOL METAB
JI Mol. Metab.
PD MAY
PY 2021
VL 47
AR 101183
DI 10.1016/j.molmet.2021.101183
EA FEB 2021
PG 17
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA RP0BT
UT WOS:000641403000002
PM 33548500
OA Green Published, Green Submitted, gold
DA 2023-06-08
ER

PT J
AU Vila, AV
   Collij, V
   Sanna, S
   Sinha, T
   Imhann, F
   Bourgonje, AR
   Mujagic, Z
   Jonkers, DMAE
   Masclee, AAM
   Fu, JY
   Kurilshikov, A
   Wijmenga, C
   Zhernakova, A
   Weersma, RK
AF Vila, Arnau Vich
   Collij, Valerie
   Sanna, Serena
   Sinha, Trishla
   Imhann, Floris
   Bourgonje, Arno R.
   Mujagic, Zlatan
   Jonkers, Daisy M. A. E.
   Masclee, Ad A. M.
   Fu, Jingyuan
   Kurilshikov, Alexander
   Wijmenga, Cisca
   Zhernakova, Alexandra
   Weersma, Rinse K.
TI Impact of commonly used drugs on the composition and metabolic function
   of the gut microbiota
SO NATURE COMMUNICATIONS
LA English
DT Article
ID PROTON PUMP INHIBITORS; IRRITABLE-BOWEL-SYNDROME; IDENTIFICATION;
   RESISTANCE; ARTHRITIS
AB The human gut microbiota has now been associated with drug responses and efficacy, while chemical compounds present in these drugs can also impact the gut bacteria. However, drug-microbe interactions are still understudied in the clinical context, where polypharmacy and comorbidities co-occur. Here, we report relations between commonly used drugs and the gut microbiome. We performed metagenomics sequencing of faecal samples from a population cohort and two gastrointestinal disease cohorts. Differences between users and non-users were analysed per cohort, followed by a meta-analysis. While 19 of 41 drugs are found to be associated with microbial features, when controlling for the use of multiple medications, proton-pump inhibitors, metformin, antibiotics and laxatives show the strongest associations with the microbiome. We here provide evidence for extensive changes in taxonomy, metabolic potential and resistome in relation to commonly used drugs. This paves the way for future studies and has implications for current microbiome studies by demonstrating the need to correct for multiple drug use. Here, via a metagenomics analysis of population-based and disease cohorts, Vich Vila et al. study the impact of 41 commonly used medications on the taxonomic structures, metabolic potential and resistome of the gut microbiome, underscoring the importance of correcting for multiple drug use in microbiome studies.
C1 [Vila, Arnau Vich; Collij, Valerie; Imhann, Floris; Bourgonje, Arno R.; Weersma, Rinse K.] Univ Groningen, Dept Gastroenterol & Hepatol, Groningen, Netherlands.
   [Vila, Arnau Vich; Collij, Valerie; Sanna, Serena; Sinha, Trishla; Imhann, Floris; Bourgonje, Arno R.; Fu, Jingyuan; Kurilshikov, Alexander; Wijmenga, Cisca; Zhernakova, Alexandra; Weersma, Rinse K.] Univ Med Ctr Groningen, Groningen, Netherlands.
   [Vila, Arnau Vich; Collij, Valerie; Sanna, Serena; Sinha, Trishla; Imhann, Floris; Fu, Jingyuan; Kurilshikov, Alexander; Wijmenga, Cisca; Zhernakova, Alexandra] Univ Groningen, Dept Genet, Groningen, Netherlands.
   [Mujagic, Zlatan; Jonkers, Daisy M. A. E.; Masclee, Ad A. M.] Maastricht Univ, Div Gastroenterol Hepatol, Med Ctr, Maastricht, Netherlands.
C3 University of Groningen; University of Groningen; University of
   Groningen; Maastricht University
RP Weersma, RK (通讯作者)，Univ Groningen, Dept Gastroenterol & Hepatol, Groningen, Netherlands.; Weersma, RK (通讯作者)，Univ Med Ctr Groningen, Groningen, Netherlands.
EM r.k.weersma@umcg.nl
RI Fu, Jingyuan/E-8980-2012; Kurilshikov, Alexander/GWC-1519-2022; sanna,
   serena/H-3009-2019; Fu, Jingyuan/ABE-6868-2020; Wijmenga,
   Cisca/AAE-7719-2019; Fu, JY/GRR-6179-2022; Sinha, Trishla/GRS-4636-2022;
   Weersma, Rinse/ABE-3807-2021; Zhernakova, Alexandra/ABA-9372-2020
OI Kurilshikov, Alexander/0000-0003-2541-5627; sanna,
   serena/0000-0002-3768-1749; Fu, Jingyuan/0000-0001-5578-1236; Wijmenga,
   Cisca/0000-0002-5635-1614; Sinha, Trishla/0000-0002-0992-7983;
   Bourgonje, Arno/0000-0001-5754-3821
FU Netherlands Organization for Scientific Research (NWO) [016.136.308,
   016.178.056, 864.13.013]; Dutch Digestive Foundation [D16-14];
   University of Groningen; Netherlands' Top Institute Food and Nutrition -
   ERC [GH001, ERC-671274]; Spinoza award (NWO) [SPI 92-266]; ERC
   [ERC-715772]; CardioVasculair Onderzoek Nederland grant [CVON 2012-03]
FX We would like to thank all participants from the three cohorts used in
   this study for providing their phenotypes and stool samples: LifeLines
   DEEP, the UMCG IBD cohort and the Maastricht University Medical Center
   IBS cohort. Furthermore, we thank B.H. Jansen for logistic and
   laboratory support and the IBD nurses at the UMCG IBD clinic, M.A.Y.
   Klaassen and L. Bolte, for patient inclusion and collection of the
   samples. We also thank K. McIntyre, who is employed by the Department of
   Genetics, UMCG, for English and scientific editing services. R.K.W.,
   A.Z. and J.F. are supported by VIDI grants (016.136.308, 016.178.056 and
   864.13.013) from the Netherlands Organization for Scientific Research
   (NWO). R.K.W. is further supported by a Diagnostics Grant from the Dutch
   Digestive Foundation (D16-14). A.Z. holds a Rosalind Franklin fellowship
   from the University of Groningen. Sequencing of the control cohort was
   funded by a grant from the Netherlands' Top Institute Food and Nutrition
   GH001 to C.W., who is further supported by an ERC advanced grant
   (ERC-671274) and a Spinoza award (NWO SPI 92-266). A.Z. is supported by
   an ERC starting grant (ERC-715772). J.F. and A.Z. are supported by a
   CardioVasculair Onderzoek Nederland grant (CVON 2012-03). Z.M. holds a
   Niels Stensen fellowship (from Amsterdam, the Netherlands).
CR Baumgart DC, 2012, LANCET, V380, P1590, DOI 10.1016/S0140-6736(12)60026-9
   Chen J, 2016, GENOME MED, V8, DOI 10.1186/s13073-016-0299-7
   Chey WD, 2015, JAMA-J AM MED ASSOC, V313, P949, DOI 10.1001/jama.2015.0954
   Clayton TA, 2009, P NATL ACAD SCI USA, V106, P14728, DOI 10.1073/pnas.0904489106
   Collij V, 2016, INFLAMM BOWEL DIS, V22, P2562, DOI 10.1097/MIB.0000000000000912
   de Meij TGJ, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0164731
   Doestzada M, 2018, PROTEIN CELL, V9, P432, DOI 10.1007/s13238-018-0547-2
   Falony G, 2016, SCIENCE, V352, P560, DOI 10.1126/science.aad3503
   Figueiras A, 2010, AAPS PHARMSCITECH, V11, P233, DOI 10.1208/s12249-009-9375-2
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Franzosa EA, 2019, NAT MICROBIOL, V4, P293, DOI 10.1038/s41564-018-0306-4
   Imhann F, 2019, BMC GASTROENTEROL, V19, DOI 10.1186/s12876-018-0917-5
   Imhann F, 2017, GUT MICROBES, V8, P351, DOI 10.1080/19490976.2017.1284732
   Imhann F, 2016, GUT, V65, P740, DOI 10.1136/gutjnl-2015-310376
   Jackson MA, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-018-05184-7
   Jackson MA, 2016, GUT, V65, P749, DOI 10.1136/gutjnl-2015-310861
   Kaminski J, 2015, PLOS COMPUT BIOL, V11, DOI 10.1371/journal.pcbi.1004557
   Kim JY, 2009, J BACTERIOL, V191, P3273, DOI 10.1128/JB.00151-09
   Luppens SBI, 2008, ORAL MICROBIOL IMMUN, V23, P183, DOI 10.1111/j.1399-302X.2007.00409.x
   Maier L, 2018, NATURE, V555, P623, DOI 10.1038/nature25979
   Malizia T., 1998, Journal of Antimicrobial Chemotherapy, V41, P29, DOI 10.1093/jac/41.suppl_2.29
   Mathur R, 2013, J CLIN ENDOCR METAB, V98, pE698, DOI 10.1210/jc.2012-3144
   Mathur R, 2013, OBESITY, V21, P748, DOI 10.1002/oby.20277
   Muller RT, 2015, BIOL CHEM, V396, P1083, DOI 10.1515/hsz-2015-0150
   Mujagic Z, 2016, SCI REP-UK, V6, DOI 10.1038/srep26420
   Mundell Lewis, 2017, BMJ Open Qual, V6, pe000209, DOI 10.1136/bmjoq-2017-000209
   Ordas I, 2012, LANCET, V380, P1606, DOI 10.1016/S0140-6736(12)60150-0
   Peterfreund GL, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0046966
   Rodvold KA, 1999, CLIN PHARMACOKINET, V37, P385, DOI 10.2165/00003088-199937050-00003
   Schaubeck M, 2016, GUT, V65, P225, DOI 10.1136/gutjnl-2015-309333
   Takagi T, 2018, J CLIN BIOCHEM NUTR, V62, P100, DOI 10.3164/jcbn.17-78
   Taneja V, 2014, FEBS LETT, V588, P4244, DOI 10.1016/j.febslet.2014.05.034
   Tap J, 2017, GASTROENTEROLOGY, V152, P111, DOI 10.1053/j.gastro.2016.09.049
   Tigchelaar EF, 2015, BMJ OPEN, V5, DOI 10.1136/bmjopen-2014-006772
   Tropini C, 2018, CELL, V173, P1742, DOI 10.1016/j.cell.2018.05.008
   Truong DT, 2015, NAT METHODS, V12, P902, DOI 10.1038/nmeth.3589
   Vandeputte D, 2016, GUT, V65, P57, DOI 10.1136/gutjnl-2015-309618
   Vijayvargiya P, 2018, CLIN GASTROENTEROL H, V16, P522, DOI 10.1016/j.cgh.2017.06.039
   Vila AV, 2018, SCI TRANSL MED, V10, DOI 10.1126/scitranslmed.aap8914
   Willer CJ, 2010, BIOINFORMATICS, V26, P2190, DOI 10.1093/bioinformatics/btq340
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Zhang X, 2015, NAT MED, V21, P895, DOI 10.1038/nm.3914
   Zhernakova A, 2016, SCIENCE, V352, P565, DOI 10.1126/science.aad3369
NR 43
TC 285
Z9 289
U1 20
U2 114
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2041-1723
J9 NAT COMMUN
JI Nat. Commun.
PD JAN 17
PY 2020
VL 11
IS 1
AR 362
DI 10.1038/s41467-019-14177-z
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA KN1YY
UT WOS:000514638400002
PM 31953381
OA Green Published, gold
HC Y
HP N
DA 2023-06-08
ER

PT J
AU Aggarwal, H
   Pathak, P
   Kumar, Y
   Jagavelu, K
   Dikshit, M
AF Aggarwal, Hobby
   Pathak, Priya
   Kumar, Yashwant
   Jagavelu, Kumaravelu
   Dikshit, Madhu
TI Modulation of Insulin Resistance, Dyslipidemia and Serum Metabolome in
   iNOS Knockout Mice following Treatment with Nitrite, Metformin,
   Pioglitazone, and a Combination of Ampicillin and Neomycin
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE iNOS(-); -; insulin resistance; dyslipidemia; metabolomic analysis
ID L-ARGININE SUPPLEMENTATION; DIET-INDUCED OBESITY; OXIDE SYNTHASE
   INHIBITOR; GUT MICROBIOTA; OXIDATIVE STRESS; NITRATE SUPPLEMENTATION;
   ENDOTHELIAL DYSFUNCTION; INORGANIC NITRATE; SKELETAL-MUSCLE; OPHTHALMIC
   ACID
AB Oxidative and nitrosative stress plays a pivotal role in the incidence of metabolic disorders. Studies from this lab and others in iNOS(-/-) mice have demonstrated occurrence of insulin resistance (IR), hyperglycemia and dyslipidemia highlighting the importance of optimal redox balance. The present study evaluates role of nitrite, L-arginine, antidiabetics (metformin, pioglitazone) and antibiotics (ampicillin-neomycin combination, metronidazole) on metabolic perturbations observed in iNOS(-/-) mice. The animals were monitored for glucose tolerance (IPGTT), IR (insulin, HOMA-IR, QUICKI), circulating lipids and serum metabolomics (LC-MS). Hyperglycemia, hyperinsulinemia and IR were rescued by nitrite, antidiabetics, and antibiotics treatments in iNOS(-/-) mice. Glucose intolerance was improved with nitrite, metformin and pioglitazone treatment, while ampicillin-neomycin combination normalised the glucose utilization in iNOS(-/-) mice. Increased serum phosphatidylethanolamine lipids in iNOS(-/-) mice were reversed by metformin, pioglitazone and ampicillin-neomycin; dyslipidemia was however marginally improved by nitrite treatment. The metabolic improvements were associated with changes in selected serum metabolites-purines, ceramide, 10-hydroxydecanoate, glucosaminate, diosmetin, sebacic acid, 3-nitrotyrosine and cysteamine. Bacterial metabolites-hippurate, indole-3-ethanol; IR marker-aminoadipate and oxidative stress marker-ophthalmate were reduced by pioglitazone and ampicillin-neomycin, but not by nitrite and metformin treatment. Results obtained in the present study suggest a crucial role of gut microbiota in the metabolic perturbations observed in iNOS(-/-) mice.
C1 [Aggarwal, Hobby; Pathak, Priya; Jagavelu, Kumaravelu; Dikshit, Madhu] CSIR Cent Drug Res Inst, Pharmacol Div, Lucknow 226031, India.
   [Kumar, Yashwant; Dikshit, Madhu] Translat Hlth Sci & Technol Inst, Noncommunicable Dis Div, Faridabad 121001, India.
C3 Council of Scientific & Industrial Research (CSIR) - India; CSIR -
   Central Drug Research Institute (CDRI); Department of Biotechnology
   (DBT) India; Translational Health Science & Technology Institute (THSTI)
RP Dikshit, M (通讯作者)，CSIR Cent Drug Res Inst, Pharmacol Div, Lucknow 226031, India.; Dikshit, M (通讯作者)，Translat Hlth Sci & Technol Inst, Noncommunicable Dis Div, Faridabad 121001, India.
EM hobby.agg@gmail.com; priyapathak87@gmail.com; y.kumar@thsti.res.in;
   kumaraveluj@cdri.res.in; drmadhudikshit@gmail.com
RI Pathak, Priya/GPC-7456-2022
OI Jagavelu, Kumaravelu/0000-0002-9235-0600; Pathak,
   Priya/0000-0002-4150-0058
FU JC Bose National fellowship [SB/SE/JCB-017/2015]; THSTI core grant;
   Indian Council of Medical Research; Council of Scientific and Industrial
   Research, India
FX The present study was supported by JC Bose National fellowship
   [SB/SE/JCB-017/2015] and THSTI core grant to Madhu Dikshit. Research
   fellowships to H.A. from Indian Council of Medical Research and P.P.
   from Council of Scientific and Industrial Research, India are
   acknowledged.
CR Adeshirlarijaney A, 2020, GUT MICROBES, V11, P253, DOI 10.1080/19490976.2020.1717719
   Aggarwal H., VANCOMYCIN INDUCED M
   Aggarwal H, 2019, OXIDATIVE STRESS IN HEART DISEASES, P461, DOI 10.1007/978-981-13-8273-4_21
   Aggarwal H, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9080736
   Al-Sulaiti H, 2019, J TRANSL MED, V17, DOI 10.1186/s12967-019-2096-8
   Backhed F, 2004, P NATL ACAD SCI USA, V101, P15718, DOI 10.1073/pnas.0407076101
   Backhed F, 2007, P NATL ACAD SCI USA, V104, P979, DOI 10.1073/pnas.0605374104
   Bai J, 2016, J ETHNOPHARMACOL, V194, P717, DOI 10.1016/j.jep.2016.10.043
   Baur JA, 2014, CELL METAB, V20, P197, DOI 10.1016/j.cmet.2014.07.013
   Radilla-Vazquez RB, 2016, OBESITY FACTS, V9, P1, DOI 10.1159/000442479
   Berger JP, 2005, TRENDS PHARMACOL SCI, V26, P244, DOI 10.1016/j.tips.2005.03.003
   Brial F, 2021, GUT, V70, P2105, DOI 10.1136/gutjnl-2020-323314
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Carlstrom M, 2010, P NATL ACAD SCI USA, V107, P17716, DOI 10.1073/pnas.1008872107
   Carvalho BM, 2012, DIABETOLOGIA, V55, P2823, DOI 10.1007/s00125-012-2648-4
   Chou CJ, 2008, NESTLE NUTR WORKS SE, V62, P127, DOI 10.1159/000146256
   Chung S, 2020, FOOD SCI NUTR, V8, P5976, DOI 10.1002/fsn3.1883
   Coburn LA, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0033546
   Cordero-Herrera I, 2020, NITRIC OXIDE-BIOL CH, V97, P48, DOI 10.1016/j.niox.2020.01.013
   Cox LM, 2013, CELL METAB, V17, P883, DOI 10.1016/j.cmet.2013.05.004
   Cuzzocrea S, 2000, AM J RESP CRIT CARE, V162, P1859, DOI 10.1164/ajrccm.162.5.9912125
   Drel VR, 2010, ENDOCRINOLOGY, V151, P2547, DOI 10.1210/en.2009-1342
   Duan YS, 2021, ENVIRON INT, V155, DOI 10.1016/j.envint.2021.106609
   Dudzinska W., 2014, J BIOMED SCI ENG, V07, P38
   Errami M, 2008, J PHARMACOL EXP THER, V324, P1196, DOI 10.1124/jpet.107.133975
   Fujisaka S, 2016, J CLIN INVEST, V126, P4430, DOI 10.1172/JCI86674
   Gandhi M., 2019, PEDIAT INFECT DIS, V1, P67, DOI [10.5005/jp-journals-10081-1214, DOI 10.5005/JP-JOURNALS-10081-1214]
   Ghasemi A, 2017, NITRIC OXIDE-BIOL CH, V70, P9, DOI 10.1016/j.niox.2017.08.003
   Gheibi S, 2018, NITRIC OXIDE-BIOL CH, V75, P27, DOI 10.1016/j.niox.2018.02.002
   Goto T, 1999, J NUTR BIOCHEM, V10, P274, DOI 10.1016/S0955-2863(99)00008-X
   Hameed A, 2020, J CLIN MED, V9, DOI 10.3390/jcm9072257
   Hardie DG, 2012, NAT REV MOL CELL BIO, V13, P251, DOI 10.1038/nrm3311
   Hezel MP, 2015, REDOX BIOL, V5, P234, DOI 10.1016/j.redox.2015.05.004
   Hoerr V, 2012, J PROTEOME RES, V11, P3231, DOI 10.1021/pr201274r
   House LM, 2015, CARDIOVASC DIABETOL, V14, DOI 10.1186/s12933-015-0223-2
   Hwang I, 2015, FASEB J, V29, P2397, DOI 10.1096/fj.14-265983
   Incalza MA, 2018, VASC PHARMACOL, V100, P1, DOI 10.1016/j.vph.2017.05.005
   Jain M, 2012, CHEM BIOL DRUG DES, V79, P459, DOI 10.1111/j.1747-0285.2011.01286.x
   Jiang H, 2014, FREE RADICAL BIO MED, V67, P51, DOI 10.1016/j.freeradbiomed.2013.10.809
   Jobgen WJ, 2009, J NUTR, V139, P230, DOI 10.3945/jn.108.096362
   Johannesen J, 2000, DIABETES CARE, V23, P560, DOI 10.2337/diacare.23.4.560
   Kakimoto PA, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0211733
   Kamo T, 2020, CIRCULATION, V142
   Kanuri BN, 2017, SCI REP-UK, V7, DOI 10.1038/srep41009
   Khan MP, 2015, DIABETES, V64, P2609, DOI 10.2337/db14-1611
   Khedara A, 1996, J NUTR, V126, P2563, DOI 10.1093/jn/126.10.2563
   Kim F, 2008, ARTERIOSCL THROM VAS, V28, P1982, DOI 10.1161/ATVBAHA.108.169722
   Kina-Tanada M, 2017, DIABETOLOGIA, V60, P1138, DOI 10.1007/s00125-017-4259-6
   Konrad D, 2014, PHYSIOLOGY, V29, P304, DOI 10.1152/physiol.00014.2014
   Kroncke KD, 1998, CLIN EXP IMMUNOL, V113, P147
   Kumar A, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-68796-4
   Kundu S, 2009, J CELL BIOCHEM, V106, P119, DOI 10.1002/jcb.21982
   Kuno T, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-19545-1
   Lee HJ, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-49578-z
   Li ZY, 2006, CELL METAB, V3, P321, DOI 10.1016/j.cmet.2006.03.007
   Liu LY, 2021, J PHARMACEUT BIOMED, V200, DOI 10.1016/j.jpba.2021.114058
   Lundberg JO, 2018, CELL METAB, V28, P9, DOI 10.1016/j.cmet.2018.06.007
   Ma DWL, 2016, NUTR DIABETES, V6, DOI 10.1038/nutd.2016.27
   Matthys KE, 1997, MEDIAT INFLAMM, V6, P3, DOI 10.1080/09629359791875
   Membrez M, 2008, FASEB J, V22, P2416, DOI 10.1096/fj.07-102723
   Million M, 2018, HUM MICROBIOME J, V10, P27, DOI [10.1016/j.humic.2018.07.002, DOI 10.1016/J.HUMIC.2018.07.002]
   Milsom AB, 2012, ANTIOXID REDOX SIGN, V17, P422, DOI 10.1089/ars.2011.4156
   Monti LD, 2012, DIABETES OBES METAB, V14, P893, DOI 10.1111/j.1463-1326.2012.01615.x
   Nakata S, 2008, CIRCULATION, V117, P2211, DOI 10.1161/CIRCULATIONAHA.107.742692
   Ohtake K, 2015, NITRIC OXIDE-BIOL CH, V44, P31, DOI 10.1016/j.niox.2014.11.009
   Ormazabal V, 2018, CARDIOVASC DIABETOL, V17, DOI 10.1186/s12933-018-0762-4
   Pathak P, 2019, EUR J PHARMACOL, V855, P90, DOI 10.1016/j.ejphar.2019.05.005
   Pautz A, 2010, NITRIC OXIDE-BIOL CH, V23, P75, DOI 10.1016/j.niox.2010.04.007
   Pillarisetti S, 2016, TRENDS PHARMACOL SCI, V37, P207, DOI 10.1016/j.tips.2015.11.009
   Popov D, 2002, CELL TISSUE RES, V308, P109, DOI 10.1007/s00441-001-0509-4
   Rawat V, 2012, N AM J MED SCI, V4, P563, DOI 10.4103/1947-2714.103315
   Roager HM, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-018-05470-4
   Rodrigues RR, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.02306
   Roisin-Bouffay C, 2008, DIABETOLOGIA, V51, P1192, DOI 10.1007/s00125-008-1017-9
   Servillo L, 2018, BBA-GEN SUBJECTS, V1862, P991, DOI 10.1016/j.bbagen.2018.01.015
   Shankar RR, 2000, DIABETES, V49, P684, DOI 10.2337/diabetes.49.5.684
   Singh V, 2018, CELL, V175, P679, DOI 10.1016/j.cell.2018.09.004
   Soga T, 2006, J BIOL CHEM, V281, P16768, DOI 10.1074/jbc.M601876200
   Suarez-Zamorano N, 2015, NAT MED, V21, P1497, DOI 10.1038/nm.3994
   Tenopoulou M, 2018, JCI INSIGHT, V3, DOI 10.1172/jci.insight.122156
   Timpani CA, 2017, NEUROTHERAPEUTICS, V14, P429, DOI 10.1007/s13311-016-0494-7
   Tsutsui M, 2015, J PHARMACOL SCI, V127, P42, DOI 10.1016/j.jphs.2014.10.002
   Varadaiah YGC, 2022, ARCH PHYSIOL BIOCHEM, V128, P87, DOI 10.1080/13813455.2019.1663219
   Villanueva C, 2010, FREE RADICAL BIO MED, V49, P307, DOI 10.1016/j.freeradbiomed.2010.04.004
   Viollet B, 2009, ACTA PHYSIOL, V196, P81, DOI 10.1111/j.1748-1716.2009.01970.x
   Wang S, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-31353-1
   Wang TJ, 2013, J CLIN INVEST, V123, P4309, DOI 10.1172/JCI64801
   Warpeha KM, 1999, FASEB J, V13, P1825, DOI 10.1096/fasebj.13.13.1825
   Wong J M, 1995, Adv Pharmacol, V34, P155
   Yao HY, 2020, GENES NUTR, V15, DOI 10.1186/s12263-020-00671-3
   Yokoyama H, 2003, DIABETES CARE, V26, P2426, DOI 10.2337/diacare.26.8.2426
   Zarrinpar A, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-018-05336-9
   Zhang L., 2015, J ENDOCRINOL DIAB, V2, P1, DOI [DOI 10.1186/S40537-015-0021-4, 10.15226/2374-6890/2/3/00127]
   Zhang X, 2015, SCI REP-UK, V5, DOI 10.1038/srep14405
   Zou J, 2018, CELL HOST MICROBE, V23, P41, DOI 10.1016/j.chom.2017.11.003
NR 95
TC 8
Z9 8
U1 2
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JAN
PY 2022
VL 23
IS 1
AR 195
DI 10.3390/ijms23010195
PG 19
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA YF5GK
UT WOS:000741834600001
PM 35008623
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Al-Jameel, SS
AF Al-Jameel, Suhailah S.
TI Association of diabetes and microbiota: An update
SO SAUDI JOURNAL OF BIOLOGICAL SCIENCES
LA English
DT Review
DE Diabetes; Insulin Resistance; Microbiota; Metagenomics; Inflammation
ID HUMAN GUT MICROBIOME; HIGH-FAT DIET; INTESTINAL MICROBIOTA;
   GLUCOSE-INTOLERANCE; BARIATRIC SURGERY; GASTRIC BYPASS; BLOOD-GLUCOSE;
   PROBIOTICS; INFLAMMATION; METFORMIN
AB Diabetes is an emerging health condition globally and is suggested to have a direct connection with the gut microbiota that determine our metabolic outcomes. Sensitivity to insulin and glucose metabolism is normal in healthy people as compared to those people who cannot maintain their glucose metabolism. One of the reasons of the differences is that healthy people have different microbiome that leads to achieve more short chain fatty acids and make up more branched amino acids, while the gut microbiota of the other group of people are more likely to produce compounds that affects glucose metabolism. Herein, this review will pre-sent the research related to the impact of gut microbes on diabetes carried out in the past decade. The review focus on the relation between gut microbiota and Type-1 Diabetes (T1D), Type-2 Diabetes (T2D), and how gut microbiota could be an alternative therapy for treatment of diabetes. (c) 2021 The Author(s). Published by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
C1 [Al-Jameel, Suhailah S.] Imam Abdulrahman Bin Faisal Univ, Coll Sci, Dept Chem, POB 1982, Dammam 31441, Saudi Arabia.
C3 Imam Abdulrahman Bin Faisal University
RP Al-Jameel, SS (通讯作者)，Imam Abdulrahman Bin Faisal Univ, Coll Sci, Dept Chem, POB 1982, Dammam 31441, Saudi Arabia.
EM ssaljameel@iau.edu.sa
FU Imam Abdulrahman bin Faisal University
FX The author thanks Imam Abdulrahman bin Faisal University for their
   support.
CR Adeshirlarijaney A, 2020, GUT MICROBES, V11, P253, DOI 10.1080/19490976.2020.1717719
   Alkharsah KR, 2019, J KING SAUD UNIV SCI, V31, P999, DOI 10.1016/j.jksus.2018.07.018
   Aoki R, 2017, SCI REP-UK, V7, DOI 10.1038/srep43522
   Aron-Wisnewsky J, 2020, NAT REV GASTRO HEPAT, V17, P279, DOI 10.1038/s41575-020-0269-9
   Balakumar M, 2018, EUR J NUTR, V57, P279, DOI 10.1007/s00394-016-1317-7
   Barengolts E, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0194171
   Beli E, 2018, DIABETES, V67, P1867, DOI 10.2337/db18-0158
   Brown CT, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0025792
   Candela M, 2016, BRIT J NUTR, V116, P80, DOI 10.1017/S0007114516001045
   Chelakkot C, 2018, EXP MOL MED, V50, DOI 10.1038/emm.2017.282
   Chen P, 2014, NUTRITION, V30, P1061, DOI 10.1016/j.nut.2014.03.022
   Dagdeviren S, 2017, FASEB J, V31, P701, DOI 10.1096/fj.201600832R
   Dallanora S, 2018, ARCH GYNECOL OBSTET, V298, P477, DOI 10.1007/s00404-018-4809-2
   Das S, 2019, MICROBIAL DIVERSITY IN THE GENOMIC ERA, pXXI
   David LA, 2014, NATURE, V505, P559, DOI 10.1038/nature12820
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Erdogan Askin, 2015, Curr Gastroenterol Rep, V17, P16, DOI 10.1007/s11894-015-0436-2
   Fan Y, 2021, NAT REV MICROBIOL, V19, P55, DOI 10.1038/s41579-020-0433-9
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Ganesan K, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19123720
   Gao RY, 2018, OBESITY, V26, P351, DOI 10.1002/oby.22088
   Gou W, 2021, DIABETES CARE
   Graessler J, 2013, PHARMACOGENOMICS J, V13, P514, DOI 10.1038/tpj.2012.43
   Gui J, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0064585
   Hajjo H, 2020, CURR OPIN NEUROBIOL, V62, P53, DOI 10.1016/j.conb.2019.10.009
   Hamer HM, 2012, AM J PHYSIOL-GASTR L, V302, pG1, DOI 10.1152/ajpgi.00048.2011
   He Y, 2018, NAT MED, V24, P1532, DOI 10.1038/s41591-018-0164-x
   Hill C, 2014, NAT REV GASTRO HEPAT, V11, P506, DOI 10.1038/nrgastro.2014.66
   Hoffmann C, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0066019
   Honda K, 2012, J CLIN BIOCHEM NUTR, V51, P96, DOI 10.3164/jcbn.11-07
   Johnson JS, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-13036-1
   Kamada N, 2013, NAT REV IMMUNOL, V13, P321, DOI 10.1038/nri3430
   Kanbay M, 2018, INT UROL NEPHROL, V50, P1453, DOI 10.1007/s11255-018-1873-2
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kasinska MA, 2015, POL ARCH MED WEWN, V125, P803, DOI 10.20452/pamw.3156
   Kesika P, 2019, BIOMED RES INT, V2019, DOI 10.1155/2019/1531567
   Kikuchi K, 2018, BIOCHEM BIOPH RES CO, V501, P1041, DOI 10.1016/j.bbrc.2018.05.105
   Kim SH, 2014, J APPL MICROBIOL, V117, P834, DOI 10.1111/jam.12573
   Kootte RS, 2012, DIABETES OBES METAB, V14, P112, DOI 10.1111/j.1463-1326.2011.01483.x
   Lagier JC, 2012, FRONT CELL INFECT MI, V2, DOI 10.3389/fcimb.2012.00136
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Le Chatelier E, 2013, NATURE, V500, P541, DOI 10.1038/nature12506
   Lim SM, 2016, NUTR RES, V36, P337, DOI 10.1016/j.nutres.2015.12.001
   Lippert K, 2017, BENEF MICROBES, V8, P545, DOI 10.3920/BM2016.0184
   Lynch SV, 2016, NEW ENGL J MED, V375, P2369, DOI 10.1056/NEJMra1600266
   Mafra D, 2015, CLIN KIDNEY J, V8, P332, DOI 10.1093/ckj/sfv026
   Malik F, 2018, DIABETES-METAB RES, V34, DOI 10.1002/dmrr.2975
   Martinic A, 2018, J PROTEOME RES, V17, P2790, DOI 10.1021/acs.jproteome.8b00282
   Mazloom Z, 2013, IRAN J MED SCI, V38, P38
   Mika A, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0125889
   Morgan XC, 2014, GASTROENTEROLOGY, V146, P1437, DOI 10.1053/j.gastro.2014.01.049
   Murphy R, 2017, OBES SURG, V27, P917, DOI 10.1007/s11695-016-2399-2
   Murri M, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-46
   Needell JC, 2016, CURR DIABETES REP, V16, DOI 10.1007/s11892-016-0781-z
   Nielsen DS, 2014, FEBS LETT, V588, P4234, DOI 10.1016/j.febslet.2014.04.010
   Nikbakht E, 2018, EUR J NUTR, V57, P95, DOI 10.1007/s00394-016-1300-3
   Palau-Rodriguez M, 2015, FRONT MICROBIOL, V6, DOI [10.3339/fmicb.2075.07751, 10.3389/fmicb.2015.01151]
   Park DY, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0059470
   Pascale A, 2018, ENDOCRINE, V61, P357, DOI 10.1007/s12020-018-1605-5
   Pedersen C, 2016, BRIT J NUTR, V116, P1869, DOI 10.1017/S0007114516004086
   Pussinen PJ, 2011, DIABETES CARE, V34, P392, DOI 10.2337/dc10-1676
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Rajendhran J, 2011, MICROBIOL RES, V166, P99, DOI 10.1016/j.micres.2010.02.003
   Ringel-Kulka T, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0064315
   Ryan KK, 2014, NATURE, V509, P183, DOI 10.1038/nature13135
   Sabit H, 2021, HELIYON, V7, DOI 10.1016/j.heliyon.2021.e06105
   Sasaki M, 2013, BMC GASTROENTEROL, V13, DOI 10.1186/1471-230X-13-81
   Schnorr SL, 2014, NAT COMMUN, V5, DOI 10.1038/ncomms4654
   Sedighi M, 2017, MICROB PATHOGENESIS, V111, P362, DOI 10.1016/j.micpath.2017.08.038
   Singhvi N, 2020, INDIAN J MICROBIOL, V60, P26, DOI 10.1007/s12088-019-00825-x
   Stenman LK, 2014, BENEF MICROBES, V5, P437, DOI 10.3920/BM2014.0014
   Su BL, 2015, J DIABETES, V7, P729, DOI 10.1111/1753-0407.12232
   Suarez-Zamorano N, 2015, NAT MED, V21, P1497, DOI 10.1038/nm.3994
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Tang WHW, 2017, CIRC RES, V120, P1183, DOI 10.1161/CIRCRESAHA.117.309715
   Tremaroli V, 2015, CELL METAB, V22, P228, DOI 10.1016/j.cmet.2015.07.009
   Vaarala O, 2013, CURR DIABETES REP, V13, P601, DOI 10.1007/s11892-013-0409-5
   Velasquez-Manoff M, 2015, NATURE, V518, pS3, DOI 10.1038/518S3a
   Volpi E.V, 2018, BIOTECHNIQUES, V45, P4
   Wang H, 2020, FRONT CELL INFECT MI, V9, DOI 10.3389/fcimb.2019.00455
   Woo PCY, 2007, DIAGN MICR INFEC DIS, V58, P251, DOI 10.1016/j.diagmicrobio.2006.12.005
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Wu J, 2012, CELL, V150, P366, DOI 10.1016/j.cell.2012.05.016
   Wu XK, 2010, CURR MICROBIOL, V61, P69, DOI 10.1007/s00284-010-9582-9
   Xie J, 2020, BIOMED PHARMACOTHER, V127, DOI 10.1016/j.biopha.2020.110147
   Xu J, 2015, ISME J, V9, P552, DOI 10.1038/ismej.2014.177
   Yamaguchi Y, 2016, DIGESTION, V94, P66, DOI 10.1159/000447690
   Yang PJ, 2016, OBES SURG, V26, P1576, DOI 10.1007/s11695-015-1968-0
   Yang Y, 2014, NATURE, V510, P152, DOI 10.1038/nature13279
   Yurkovetskiy L, 2013, IMMUNITY, V39, P400, DOI 10.1016/j.immuni.2013.08.013
   Zhang XY, 2017, DIABETES THER, V8, P293, DOI 10.1007/s13300-017-0226-y
   Zhang XY, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0071108
   Zhu CX, 2018, MOL MED REP, V17, P7567, DOI 10.3892/mmr.2018.8833
NR 93
TC 10
Z9 10
U1 10
U2 28
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1319-562X
EI 2213-7106
J9 SAUDI J BIOL SCI
JI Saudi J. Biol. Sci.
PD AUG
PY 2021
VL 28
IS 8
BP 4446
EP 4454
DI 10.1016/j.sjbs.2021.04.041
EA JUL 2021
PG 9
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA TQ6FB
UT WOS:000678372600012
PM 34354429
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Chen, XP
   Devaraj, S
AF Chen, Xinpu
   Devaraj, Sridevi
TI Gut Microbiome in Obesity, Metabolic Syndrome, and Diabetes
SO CURRENT DIABETES REPORTS
LA English
DT Review
DE Microbiome; Obesity; Metabolic syndrome; Diabetes; Inflammation;
   Endotoxin
ID INTESTINAL MICROBIOTA; INSULIN-RESISTANCE; IMMUNE-SYSTEM; INFLAMMATION;
   MICE; METAGENOME; METFORMIN
AB Purpose of ReviewObesity and diabetes are worldwide epidemics. There is also a growing body of evidence relating the gut microbiome composition to insulin resistance. The purpose of this review is to delineate the studies linking gut microbiota to obesity, metabolic syndrome, and diabetes.Recent findingsAnimal studies as well as proof of concept studies using fecal transplantation demonstrate the pivotal role of the gut microbiota in regulating insulin resistance states and inflammation.SummaryWhile we still need to standardize methodologies to study the microbiome, there is an abundance of evidence pointing to the link between gut microbiome, inflammation, and insulin resistance, and future studies should be aimed at identifying unifying mechanisms.
C1 [Chen, Xinpu; Devaraj, Sridevi] Baylor Coll Med, Dept Pathol & Immunol, 6621 Fannin St, Houston, TX 77030 USA.
   [Chen, Xinpu; Devaraj, Sridevi] Texas Childrens Hosp, 6621 Fannin St, Houston, TX 77030 USA.
C3 Baylor College of Medicine; Baylor College of Medicine
RP Devaraj, S (通讯作者)，Baylor Coll Med, Dept Pathol & Immunol, 6621 Fannin St, Houston, TX 77030 USA.; Devaraj, S (通讯作者)，Texas Childrens Hosp, 6621 Fannin St, Houston, TX 77030 USA.
EM xchen@bcm.edu; sxdevara@texaschildrens.org
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Amar J, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0054461
   American College of Cardiology/American Heart Association Task Force on Practice Guidelines Obesity Expert Panel, 2013, OBESITY SILVER SP S2, V2014, pS5
   [Anonymous], 2018, GUT
   Backhed F, 2004, P NATL ACAD SCI USA, V101, P15718, DOI 10.1073/pnas.0407076101
   Backhed F, 2005, SCIENCE, V307, P1915, DOI 10.1126/science.1104816
   Biagi E, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0010667
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   Caricilli AM, 2011, PLOS BIOL, V9, DOI 10.1371/journal.pbio.1001212
   Carvalho BM, 2012, DIABETOLOGIA, V55, P2823, DOI 10.1007/s00125-012-2648-4
   Claus SP, 2017, CELL METAB, V26, P6, DOI 10.1016/j.cmet.2017.06.009
   Creely SJ, 2007, AM J PHYSIOL-ENDOC M, V292, pE740, DOI 10.1152/ajpendo.00302.2006
   Dasu MR, 2010, DIABETES CARE, V33, P861, DOI 10.2337/dc09-1799
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Dethlefsen L, 2006, TRENDS ECOL EVOL, V21, P517, DOI 10.1016/j.tree.2006.06.013
   Dethlefsen L, 2011, P NATL ACAD SCI USA, V108, P4554, DOI 10.1073/pnas.1000087107
   Devaraj S, 2016, CLIN CHEM, V62, P1554, DOI 10.1373/clinchem.2016.256842
   Devaraj S, 2011, ARTERIOSCL THROM VAS, V31, P1796, DOI 10.1161/ATVBAHA.111.228924
   Donaldson GP, 2016, NAT REV MICROBIOL, V14, P20, DOI 10.1038/nrmicro3552
   Duboc H, 2019, INT J OBESITY, V43, P428, DOI 10.1038/s41366-018-0015-3
   Ejtahed HS, 2018, MICROB PATHOGENESIS, V116, P13, DOI 10.1016/j.micpath.2017.12.074
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Frazier Thomas H, 2011, JPEN J Parenter Enteral Nutr, V35, p14S, DOI 10.1177/0148607111413772
   Greenhill C, 2015, NAT REV ENDOCRINOL, V11, P627, DOI [10.1038/nrendo.2015.152, 10.1038/nrendo.2015.110, 10.1038/nrendo.2015.94, 10.1038/nrendo.2015.170, 10.1038/nrendo.2014.235]
   Gu SH, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0074957
   Gupta S, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-07230-8
   Henao-Mejia J, 2012, NATURE, V482, P179, DOI 10.1038/nature10809
   Hur KY, 2015, DIABETES METAB J, V39, P198, DOI 10.4093/dmj.2015.39.3.198
   Jialal I, 2014, J CLIN ENDOCR METAB, V99, P39, DOI 10.1210/jc.2013-3092
   Jialal I, 2012, DIABETES CARE, V35, P900, DOI 10.2337/dc11-2375
   Kadooka Y, 2010, EUR J CLIN NUTR, V64, P636, DOI 10.1038/ejcn.2010.19
   Kalliomaki M, 2008, AM J CLIN NUTR, V87, P534, DOI 10.1093/ajcn/87.3.534
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Keane KN, 2017, EUR J CLIN NUTR, V71, P904, DOI 10.1038/ejcn.2017.45
   Lam DW, 2012, CURR OPIN ENDOCRINOL, V19, P93, DOI 10.1097/MED.0b013e328350583a
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Lee YK, 2010, SCIENCE, V330, P1768, DOI 10.1126/science.1195568
   Ley RE, 2005, P NATL ACAD SCI USA, V102, P11070, DOI 10.1073/pnas.0504978102
   Ley RE, 2000, NAT REV, V6, P776
   Ley RE, 2010, CURR OPIN GASTROEN, V26, P5, DOI 10.1097/MOG.0b013e328333d751
   Lontchi-Yimagou E, 2013, CURR DIABETES REP, V13, P435, DOI 10.1007/s11892-013-0375-y
   Pahwa R, 2017, J DIABETES RES, V2017, DOI 10.1155/2017/6519785
   Pedersen C, 2016, BRIT J NUTR, V116, P1869, DOI 10.1017/S0007114516004086
   Pirola Luciano, 2017, World J Biol Chem, V8, P120, DOI 10.4331/wjbc.v8.i2.120
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Rajilic-Stojanovic M, 2014, FEMS MICROBIOL REV, V38, P996, DOI 10.1111/1574-6976.12075
   Ravussin Y, 2012, OBESITY, V20, P738, DOI 10.1038/oby.2011.111
   Rempel JD, 2013, INT J CIRCUMPOL HEAL, V72, P293, DOI 10.3402/ijch.v72i0.21190
   Ridaura VK, 2013, SCIENCE, V341, P1079, DOI 10.1126/science.1241214
   Scheithauer TPM, 2016, MOL METAB, V5, P759, DOI 10.1016/j.molmet.2016.06.002
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Swidsinski A, 2005, WORLD J GASTROENTERO, V11, P1131, DOI 10.3748/wjg.v11.i8.1131
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Turnbaugh PJ, 2009, NATURE, V457, P480, DOI 10.1038/nature07540
   Verma S, 2017, DIABETES METAB SYND, V11, P73, DOI 10.1016/j.dsx.2016.06.017
   Vrieze A, 2012, GASTROENTEROLOGY, V143, P913, DOI 10.1053/j.gastro.2012.06.031
   Whitman WB, 1998, P NATL ACAD SCI USA, V95, P6578, DOI 10.1073/pnas.95.12.6578
   Zand H, 2017, DIABETES METAB SYND, V11, pS307, DOI 10.1016/j.dsx.2017.03.006
   Zhao L, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00233
   Zietek T, 2016, FRONT IMMUNOL, V7, DOI 10.3389/fimmu.2016.00154
   Zupancic ML, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0043052
NR 62
TC 69
Z9 73
U1 7
U2 114
PU CURRENT MEDICINE GROUP
PI PHILADELPHIA
PA 400 MARKET STREET, STE 700, PHILADELPHIA, PA 19106 USA
SN 1534-4827
EI 1539-0829
J9 CURR DIABETES REP
JI Curr. Diabetes Rep.
PD DEC
PY 2018
VL 18
IS 12
AR 129
DI 10.1007/s11892-018-1104-3
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA GX5PV
UT WOS:000447802900004
PM 30338410
DA 2023-06-08
ER

PT J
AU Tian, JX
   Bai, BB
   Gao, ZZ
   Yang, YY
   Wu, HR
   Wang, XM
   Wang, J
   Li, M
   Tong, XL
AF Tian, Jiaxing
   Bai, Bingbing
   Gao, Zezheng
   Yang, Yingying
   Wu, Haoran
   Wang, Xinmiao
   Wang, Jun
   Li, Min
   Tong, Xiaolin
TI Alleviation Effects of GQD, a Traditional Chinese Medicine Formula, on
   Diabetes Rats Linked to Modulation of the Gut Microbiome
SO FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
LA English
DT Article
DE gut microbiota; type 2 diabetes mellitus; Chinese herbal medicine;
   intestinal barrier function; inflammation
ID HIGH-FAT DIET; INTESTINAL BARRIER FUNCTION; GEGEN QINLIAN DECOCTION;
   LACTOBACILLUS-ACIDOPHILUS; INSULIN-RESISTANCE; ADIPOSE-TISSUE;
   INFLAMMATION; OBESITY; INDIVIDUALS; ACIDS
AB Gegen Qinlian Decoction (GQD) is a Chinese herbal medicine that has been reported to significantly decrease blood glucose levels, which is suggested to be related to interactions with the gut microbiota. However, the protective effect of GQD on intestinal barrier function with regard to its influence on the gut microbiota has not been explored to date. In this study, we investigated the role of the gut microbiota in mediating the hypoglycemic mechanism of GQD in type 2 diabetes mellitus (T2DM) rats induced by a single intraperitoneal injection of streptozotocin after 4 weeks of high-fat diet feeding. The T2DM rats were randomly allocated to receive GQD, metformin (Met), or saline for 12 consecutive weeks, and changes in metabolic parameters, intestinal barrier function, and inflammation were investigated. Gut microbiota was analyzed using 16S rRNA gene sequencing from fecal samples, and statistical analyses were performed to correlate microbiota composition with phenotypes of the T2DM rats. GQD administration decreased the levels of blood glucose and inflammatory cytokines, and increased the levels of tight junction proteins. Besides, GQD had a protective effect on islet function, restoring intestinal permeability, and inhibiting inflammation, as evidenced by increases in the levels of serum C-peptide, occludin, and claudin-1 in the colon, and also improved the expression of serum inflammatory factors. In addition, GQD regulated the structure of the gut microbiota by increasing the proportions of short-chain fatty acids-producing and anti-inflammatory bacteria, and decreasing the proportions of conditioned pathogenic bacteria associated with the diabetic phenotype. Overall, these findings suggest that GQD could ameliorate hyperglycemia and protect islet function by regulating the structure of the gut microbiota, thereby restoring intestinal permeability and inhibiting inflammation in T2DM rats. Our study thus suggests that the hypoglycemic mechanism of GQD is mediated by its modulation of the gut microbiota.
C1 [Tian, Jiaxing; Gao, Zezheng; Yang, Yingying; Wu, Haoran; Wang, Xinmiao; Li, Min; Tong, Xiaolin] China Acad Chinese Med Sci, Guanganmen Hosp, Dept Endocrinol, Beijing, Peoples R China.
   [Bai, Bingbing; Wang, Jun] Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing, Peoples R China.
C3 China Academy of Chinese Medical Sciences; Guang'anmen Hospital, CACMS;
   Chinese Academy of Sciences; Institute of Microbiology, CAS
RP Li, M; Tong, XL (通讯作者)，China Acad Chinese Med Sci, Guanganmen Hosp, Dept Endocrinol, Beijing, Peoples R China.; Wang, J (通讯作者)，Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing, Peoples R China.
EM junwang@im.ac.cn; limin-72114@163.com; tongxiaolin@vip.163.com
RI Yang, Ying/ABD-2481-2022
FU National Natural Science Foundation of China [81430097, 81904187];
   Capital Health Development Research Project [CD2020-4-4155]; Outstanding
   Young Scientific and Technological Talents Program [ZZ13-YQ-026]; CACMS
   Scientific and Technological Innovation Fund [CI2021A01601]; Open
   Project of National Facility for Translational Medicine (Shanghai)
   [TMSK-2021-407]
FX This work was partially supported by the National Natural Science
   Foundation of China (No. 81430097, 81904187), Capital Health Development
   Research Project (CD2020-4-4155), and the Outstanding Young Scientific
   and Technological Talents Program (ZZ13-YQ-026). CACMS Scientific and
   Technological Innovation Fund, CI2021A01601; Open Project of National
   Facility for Translational Medicine (Shanghai), TMSK-2021-407.
CR Alam A, 2018, TISSUE BARRIERS, V6, DOI 10.1080/21688370.2018.1539595
   Andreasen AS, 2010, BRIT J NUTR, V104, P1831, DOI 10.1017/S0007114510002874
   Borgo F, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.00213
   Borrelli L, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-16560-6
   Boulange CL, 2016, GENOME MED, V8, DOI 10.1186/s13073-016-0303-2
   Cani PD, 2009, GUT, V58, P1091, DOI 10.1136/gut.2008.165886
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Cani PD, 2009, CURR PHARM DESIGN, V15, P1546, DOI 10.2174/138161209788168164
   Cao ZB, 2021, J ETHNOPHARMACOL, V264, DOI 10.1016/j.jep.2020.113289
   Chen L, 2020, J PHARMACOL SCI, V143, P89, DOI 10.1016/j.jphs.2020.02.009
   Chen MY, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.02380
   中华医学会糖尿病学分会, 2021, [中华糖尿病杂志, Chinese Journal of Diabetes Mellitus], V13, P315
   Creely SJ, 2007, AM J PHYSIOL-ENDOC M, V292, pE740, DOI 10.1152/ajpendo.00302.2006
   de Kort S, 2011, OBES REV, V12, P449, DOI 10.1111/j.1467-789X.2010.00845.x
   den Besten G, 2013, J LIPID RES, V54, P2325, DOI 10.1194/jlr.R036012
   [杜晨晖 Du Chenhui], 2018, [中草药, Chinese Traditional and Herbal Drugs], V49, P2302
   Ejtahed HS, 2011, J DAIRY SCI, V94, P3288, DOI 10.3168/jds.2010-4128
   Falony G, 2016, SCIENCE, V352, P560, DOI 10.1126/science.aad3503
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   FURUSE M, 1994, J CELL BIOL, V127, P1617, DOI 10.1083/jcb.127.6.1617
   Genser L, 2018, J PATHOL, V246, P217, DOI 10.1002/path.5134
   Gheibi S, 2017, BIOMED PHARMACOTHER, V95, P605, DOI 10.1016/j.biopha.2017.08.098
   Gu YY, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-01682-2
   Guo Y, 2017, DIABETES-METAB RES, V33, DOI 10.1002/dmrr.2857
   Hamilton MK, 2015, AM J PHYSIOL-GASTR L, V308, pG840, DOI 10.1152/ajpgi.00029.2015
   Hotamisligil GS, 2006, NATURE, V444, P860, DOI 10.1038/nature05485
   Hotamisligil GS, 2008, NAT REV IMMUNOL, V8, P923, DOI 10.1038/nri2449
   Kasai C, 2015, BMC GASTROENTEROL, V15, DOI 10.1186/s12876-015-0330-2
   Lenzen S, 2008, DIABETOLOGIA, V51, P216, DOI 10.1007/s00125-007-0886-7
   Lin H, 2016, SCI REP-UK, V6, DOI 10.1038/srep21618
   Magoc T, 2011, BIOINFORMATICS, V27, P2957, DOI 10.1093/bioinformatics/btr507
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Morrison DJ, 2016, GUT MICROBES, V7, P189, DOI 10.1080/19490976.2015.1134082
   Oliveira RB, 2019, LIFE SCI, V216, P10, DOI 10.1016/j.lfs.2018.11.012
   Pathak P, 2018, HEPATOLOGY, V68, P1574, DOI 10.1002/hep.29857
   Patrone V, 2018, BMC GENOMICS, V19, DOI 10.1186/s12864-018-5202-z
   Pekkala S, 2015, OBESITY, V23, P581, DOI 10.1002/oby.20993
   Pfeiffer N, 2012, ARCH MICROBIOL, V194, P901, DOI 10.1007/s00203-012-0822-1
   Pindjakova J, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.01157
   Puddu A, 2014, MEDIAT INFLAMM, V2014, DOI 10.1155/2014/162021
   Salomaki-Myftari H, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0163805
   Segata N, 2011, GENOME BIOL, V12, DOI 10.1186/gb-2011-12-6-r60
   [单思 Shan Si], 2017, [中华中医药杂志, China Journal of Traditional Chinese Medicine and Pharmacy], V32, P5342
   Singh RK, 2017, J TRANSL MED, V15, DOI 10.1186/s12967-017-1175-y
   Sonnenburg JL, 2016, NATURE, V535, P56, DOI 10.1038/nature18846
   Tong XL, 2018, MBIO, V9, DOI 10.1128/mBio.02392-17
   Wang J, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.01953
   Wang J, 2017, AM J PHYSIOL-CELL PH, V312, pC438, DOI 10.1152/ajpcell.00235.2016
   Wang Q, 2007, APPL ENVIRON MICROB, V73, P5261, DOI 10.1128/AEM.00062-07
   Wang YQ, 2017, GENOM PROTEOM BIOINF, V15, P14, DOI 10.1016/j.gpb.2017.01.001
   Wei W, 2010, EXPT METHODOLOGY PHA
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Xu J, 2015, ISME J, V9, P552, DOI 10.1038/ismej.2014.177
   Xue YB, 2021, NUCLEIC ACIDS RES, V49, pD18, DOI 10.1093/nar/gkaa1022
   Yadav H, 2007, NUTRITION, V23, P62, DOI 10.1016/j.nut.2006.09.002
   Yamauchi T, 2001, NAT MED, V7, P941, DOI 10.1038/90984
   [袁有才 Yuan Youcai], 2018, [时珍国医国药, Lishizhen Medicine and Materia Medica Research], V29, P269
   Zha LH, 2015, AM J CHINESE MED, V43, P1515, DOI 10.1142/S0192415X1550086X
   [章常华 Zhang Changhua], 2017, [中草药, Chinese Traditional and Herbal Drugs], V48, P1611
   Zhang X, 2015, SCI REP-UK, V5, DOI 10.1038/srep14405
   [周琦 Zhou Qi], 2018, [中医杂志, Journal of Traditional Chinese Medicine], V59, P973
   Zou K, 2017, ACTA PHARMACOL SIN, V38, P157, DOI 10.1038/aps.2016.125
NR 62
TC 7
Z9 8
U1 10
U2 35
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2235-2988
J9 FRONT CELL INFECT MI
JI Front. Cell. Infect. Microbiol.
PD OCT 8
PY 2021
VL 11
AR 740236
DI 10.3389/fcimb.2021.740236
PG 11
WC Immunology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Microbiology
GA WM2SD
UT WOS:000710939600001
PM 34692563
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Huang, JN
   Chen, PG
   Xiang, YT
   Liang, QQ
   Wu, TB
   Liu, JW
   Zeng, YY
   Zeng, HT
   Liang, XY
   Zhou, CC
AF Huang, Jiana
   Chen, Peigen
   Xiang, Yuting
   Liang, Qiqi
   Wu, Taibao
   Liu, Jiawen
   Zeng, Yanyan
   Zeng, Haitao
   Liang, Xiaoyan
   Zhou, Chuanchuan
TI Gut microbiota dysbiosis-derived macrophage pyroptosis causes polycystic
   ovary syndrome via steroidogenesis disturbance and apoptosis of
   granulosa cells
SO INTERNATIONAL IMMUNOPHARMACOLOGY
LA English
DT Article
DE Disulfiram; Granulosa cells; Gut microbiota; Macrophage pyroptosis;
   Metformin; Polycystic ovary syndrome
ID AKKERMANSIA-MUCINIPHILA; GASDERMIN-D; METFORMIN; WOMEN; INFLAMMASOME;
   EXPRESSION; MORPHOLOGY; THECA
AB Gut microbiota dysbiosis is critical in the etiology of polycystic ovary syndrome (PCOS). However, the mecha-nisms of gut microbiota in PCOS pathogenesis have not been fully elucidated. We aimed to explore the role of gut microbiota-derived macrophage pyroptosis in PCOS. This study conducted dehydroepiandrosterone (DHEA) induced PCOS mice model, 16S rDNA sequencing, western blot, genetic knocking out, transcriptome and translatome profiling, et al. to evaluate the underlying mechanisms. 16S rDNA sequencing showed reduced gut Akkermansia and elevated gram-negative bacteria (Desulfovibrio and Burkholderia) abundances in DHEA induced PCOS mice, which was accompanied by increased serum lipopolysaccharide (LPS). LPS could induce macrophage pyroptosis in mice ovaries, also activated in PCOS. Gasdermin D (GSDMD) is the final executor of macrophage pyroptosis. We demonstrated that Gsdmd knockout in mice could dramatically ameliorate PCOS. Mechanistically, transcriptome and translatome profiling revealed that macrophage pyroptosis disrupted estrogen production and promoted apoptosis of granulosa cells. Interferon (IFN)-gamma, which was elevated in PCOS mice serum and ovaries, enhanced macrophage pyroptosis and exacerbated its effect on estrogen receptor in granulosa cells. Inspiringly, we identified that disulfiram and metformin could augment gut Akkermansia abundance, reduce serum IFN-gamma level, inhibit macrophage pyroptosis in ovaries, therefore ameliorating PCOS. Collectively, this study emphasizes that macrophage pyroptosis, which was induced by gut microbiota dysbiosis and enhanced by IFN-gamma, plays a key role in PCOS pathogenesis through estrogen synthesis dysfunction and apoptosis of granulosa cells. Disulfiram and metformin, which enhanced gut Akkermansia abundance and suppressed macrophage pyroptosis, may be considered as potential therapeutic strategies for PCOS.
C1 [Huang, Jiana; Chen, Peigen; Xiang, Yuting; Liang, Qiqi; Wu, Taibao; Liu, Jiawen; Zeng, Yanyan; Zeng, Haitao; Liang, Xiaoyan; Zhou, Chuanchuan] Sun Yat Sen Univ, Affiliated Hosp 6, Reprod Med Ctr, Guangzhou, Guangdong, Peoples R China.
C3 Sun Yat Sen University
RP Zeng, HT; Liang, XY; Zhou, CC (通讯作者)，Sun Yat Sen Univ, Affiliated Hosp 6, Reprod Med Ctr, Guangzhou, Guangdong, Peoples R China.
EM zenghtao@mail.sysu.edu.cn; liangxy2@mail.sysu.edu.cn;
   zhouchch7@mail.sysu.edu.cn
RI Chen, Peigen/ABE-6596-2021; liang, xiaoyan/GYJ-5006-2022
OI Chen, Peigen/0000-0002-0843-7739; Xiang, Yuting/0000-0003-2371-4973
FU National Key Research and Devel-opment Program of China
   [2021YFC2700403]; Na-tional Natural Science Foundation of China
   [82071713, 81801410]; Medical Scientific Research Foundation of
   Guang-dong Province [A2021026]
FX Funding This work was supported by the National Key Research and
   Devel-opment Program of China [grant number 2021YFC2700403] ; the
   Na-tional Natural Science Foundation of China [grant numbers 82071713,
   81801410] ; and the Medical Scientific Research Foundation of Guang-dong
   Province [grant number A2021026] .
CR Abizadeh M, 2020, REPROD SCI, V27, P1742, DOI 10.1007/s43032-020-00168-9
   Amoani Benjamin, 2021, J Immunoassay Immunochem, V42, P252, DOI 10.1080/15321819.2020.1862861
   Balen AH, 2016, HUM REPROD UPDATE, V22, P687, DOI 10.1093/humupd/dmw025
   BenChetrit A, 1996, FERTIL STERIL, V65, P711, DOI 10.1016/S0015-0282(16)58201-6
   Bernier M, 2020, CELL METAB, V32, P203, DOI 10.1016/j.cmet.2020.04.019
   Bolger AM, 2014, BIOINFORMATICS, V30, P2114, DOI 10.1093/bioinformatics/btu170
   Bolyen E, 2019, NAT BIOTECHNOL, V37, P852, DOI 10.1038/s41587-019-0209-9
   Callahan BJ, 2016, NAT METHODS, V13, P581, DOI [10.1038/NMETH.3869, 10.1038/nmeth.3869]
   Caspi R, 2020, NUCLEIC ACIDS RES, V48, pD445, DOI 10.1093/nar/gkz862
   Chakravarthi VP, 2021, MOL CELL ENDOCRINOL, V527, DOI 10.1016/j.mce.2021.111208
   Chen X, 2016, CELL RES, V26, P1007, DOI 10.1038/cr.2016.100
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Douglas GM, 2020, NAT BIOTECHNOL, V38, P685, DOI 10.1038/s41587-020-0548-6
   Duan W, 2019, AM J TRANSL RES, V11, P2393
   Everard A., P NATL ACAD SCI
   Franik G, 2019, EUR J OBSTET GYN R B, V242, P166, DOI 10.1016/j.ejogrb.2019.05.045
   Franks S, 2008, HUM REPROD UPDATE, V14, P367, DOI 10.1093/humupd/dmn015
   Giampaolino P, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22042048
   Guo Y, 2020, J CLIN INVEST, V130, P6301, DOI 10.1172/JCI138234
   Hage C, 2019, HEPATOLOGY, V70, P1280, DOI 10.1002/hep.30666
   Han QX, 2021, MICROBIOME, V9, DOI 10.1186/s40168-021-01046-5
   He WT, 2015, CELL RES, V25, P1285, DOI 10.1038/cr.2015.139
   Hu H, 2020, CANCER MED-US, V9, P6791, DOI 10.1002/cam4.3346
   Hu J.J., NAT IMMUNOL 21
   Inzunza J, 2007, P NATL ACAD SCI USA, V104, P600, DOI 10.1073/pnas.0608951103
   Jakimiuk AJ, 2002, J CLIN ENDOCR METAB, V87, P5532, DOI 10.1210/jc.2002-020323
   Jia YF, 2020, REDOX BIOL, V32, DOI 10.1016/j.redox.2020.101534
   Johnson DC, 2018, NAT MED, V24, P1151, DOI 10.1038/s41591-018-0082-y
   Kim D, 2015, NAT METHODS, V12, P357, DOI [10.1038/NMETH.3317, 10.1038/nmeth.3317]
   Lee EB, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms221910348
   Li LY, 2021, FRONT PHYSIOL, V12, DOI 10.3389/fphys.2021.730196
   Liao Y, 2019, NUCLEIC ACIDS RES, V47, DOI 10.1093/nar/gkz114
   Liu R, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.00324
   Liu YS, 2021, FRONT IMMUNOL, V12, DOI 10.3389/fimmu.2021.685724
   Love MI, 2014, GENOME BIOL, V15, DOI 10.1186/s13059-014-0550-8
   Macchione IG, 2019, EUR REV MED PHARMACO, V23, P8075, DOI 10.26355/eurrev_201909_19024
   Man SM, 2017, IMMUNOL REV, V277, P61, DOI 10.1111/imr.12534
   Morris A, 2020, NAT REV ENDOCRINOL, V16, P196, DOI 10.1038/s41574-020-0332-1
   Paixao L, 2017, REPROD BIOL ENDOCRIN, V15, DOI 10.1186/s12958-017-0231-z
   Parks DH, 2014, BIOINFORMATICS, V30, P3123, DOI 10.1093/bioinformatics/btu494
   Patel U, 2017, DRUG DISCOV TODAY, V22, P186, DOI 10.1016/j.drudis.2016.08.006
   Plovier H, 2017, NAT MED, V23, P107, DOI 10.1038/nm.4236
   Qi X., NAT
   Qin L, 2016, EUR J OBSTET GYN R B, V197, P136, DOI 10.1016/j.ejogrb.2015.12.003
   Qu ZL, 2020, SCI ADV, V6, DOI 10.1126/sciadv.aba4733
   Quast Christian, 2013, Nucleic Acids Res, V41, pD590, DOI 10.1093/nar/gks1219
   Rathinam VAK, 2019, NAT IMMUNOL, V20, P527, DOI 10.1038/s41590-019-0368-3
   Rehman A, 2021, TRENDS ENDOCRIN MET, V32, P238, DOI 10.1016/j.tem.2020.12.001
   Reunanen J, 2015, APPL ENVIRON MICROB, V81, P3655, DOI 10.1128/AEM.04050-14
   Robinson N, 2019, REDOX BIOL, V26, DOI 10.1016/j.redox.2019.101239
   Segata N, 2011, GENOME BIOL, V12, DOI 10.1186/gb-2011-12-6-r60
   Shapouri-Moghaddam A, 2018, J CELL PHYSIOL, V233, P6425, DOI 10.1002/jcp.26429
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Stirling C, 2010, BMC HEALTH SERV RES, V10, DOI 10.1186/1472-6963-10-122
   Tremellen K, 2012, MED HYPOTHESES, V79, P104, DOI 10.1016/j.mehy.2012.04.016
   Tsuji G, 2020, CELL DEATH DISCOV, V6, DOI 10.1038/s41420-020-0245-8
   Uribe-Herranz M, 2020, J CLIN INVEST, V130, P466, DOI 10.1172/JCI124332
   Wang DJ, 2020, SCI TOTAL ENVIRON, V745, DOI 10.1016/j.scitotenv.2020.141049
   Wong DH, 2010, MOL HUM REPROD, V16, P251, DOI 10.1093/molehr/gaq002
   Wu WR, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.01804
   Yang F, 2019, INT J BIOL SCI, V15, P1010, DOI 10.7150/ijbs.29680
   Zhai R, 2019, FRONT CELL INFECT MI, V9, DOI 10.3389/fcimb.2019.00239
   Zhang J, 2021, J INFLAMM RES, V14, P2955, DOI 10.2147/JIR.S310116
   Zhang J, 2020, AGING-US, V12, P24270, DOI 10.18632/aging.202143
   Zhang Y, 2021, INFLAMM RES, V70, P543, DOI 10.1007/s00011-021-01457-y
   Zheng YH, 2021, EVID-BASED COMPL ALT, V2021, DOI 10.1155/2021/6674965
   Zhou JW, 2019, INT J BIOL SCI, V15, P726, DOI 10.7150/ijbs.30369
   Zhou XY, 2020, ARCH ORAL BIOL, V116, DOI 10.1016/j.archoralbio.2020.104763
   Zou J, 2021, FRONT IMMUNOL, V12, DOI 10.3389/fimmu.2021.751533
NR 69
TC 4
Z9 4
U1 15
U2 30
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1567-5769
EI 1878-1705
J9 INT IMMUNOPHARMACOL
JI Int. Immunopharmacol.
PD JUN
PY 2022
VL 107
AR 108717
DI 10.1016/j.intimp.2022.108717
EA MAR 2022
PG 13
WC Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Pharmacology & Pharmacy
GA 1C1ML
UT WOS:000792891900002
PM 35334358
DA 2023-06-08
ER

PT J
AU Akash, MSH
   Fiayyaz, F
   Rehman, K
   Sabir, S
   Rasool, MH
AF Akash, Muhammad Sajid Hamid
   Fiayyaz, Fareeha
   Rehman, Kanwal
   Sabir, Shakila
   Rasool, Muhammad Hidayat
TI Gut Microbiota and Metabolic Disorders: Advances in Therapeutic
   Interventions
SO CRITICAL REVIEWS IN IMMUNOLOGY
LA English
DT Article
DE angiopoietin-like 4; fasting induced adipose factor; G protein coupled
   receptors; short chain fatty acids; fecal microbiota transplantation
ID DIET-INDUCED OBESITY; INSULIN-RESISTANCE; BARIATRIC SURGERY;
   WEIGHT-LOSS; MOLECULAR-MECHANISMS; INDUCED INFLAMMATION;
   LIPOPROTEIN-LIPASE; OXIDATIVE STRESS; ADIPOSE-TISSUE; HUMAN HEALTH
AB Human gut microbiota consist of numerous microorganisms, but the most abundant species are Bacteroides and Firmicutes. Each human possesses a specific gut microbiota, which can be altered by diet, antibiotics, lifestyle, and genetic background. Gut microbiota perform vital functions, but in this article, we aimed to elaborate the effects of modified composition of microbiota on host metabolism. Ligands for G protein coupled receptors (GPCRs) are short-chain fatty acids (SCFAs) located on endocrine glands, epithelial cells, and adipocytes. SCFAs are produced in the distal gut by bacterial fermentation of nondigestible polysaccharides; they induce the various beneficial effects including decrease serum glucose level, insulin resistance, as well as inflammation; and they increase glucagon-like peptide-1 (GLP1) secretion. Fasting-induced adipose factor (FIAF) is suppressed by gut microbiota and results in the increased storage of fatty acids in the adipose tissues and liver. An increased lipopolysaccharide level due to altered gut microflora cause the initiation of inflammation associated with type 2 diabetes mellitus (T2DM). Intestinal dysbiosis and metabolic endotoxemia are considered key mechanisms that seem to be associated with the development of T2DM and obesity. Therapeutic interventions that can be used for the treatment of diabetes include metformin, dietary modulation, probiotics, prebiotics, fecal microbiota transplantation and bariatric surgery.
C1 [Akash, Muhammad Sajid Hamid; Fiayyaz, Fareeha; Sabir, Shakila] Govt Coll Univ Faisalabad, Dept Pharmaceut Chem, Faisalabad 38000, Punjab, Pakistan.
   [Fiayyaz, Fareeha; Rasool, Muhammad Hidayat] Govt Coll Univ Faisalabad, Dept Microbiol, Faisalabad, Punjab, Pakistan.
   [Rehman, Kanwal] Univ Agr Faisalabad, Dept Pharm, Faisalabad 38000, Pakistan.
   [Sabir, Shakila] Govt Coll Univ Faisalabad, Dept Pharmacol, Faisalabad, Punjab, Pakistan.
C3 Government College University Faisalabad; Government College University
   Faisalabad; University of Agriculture Faisalabad; Government College
   University Faisalabad
RP Akash, MSH (通讯作者)，Govt Coll Univ Faisalabad, Dept Pharmaceut Chem, Faisalabad 38000, Punjab, Pakistan.; Rehman, K (通讯作者)，Univ Agr Faisalabad, Dept Pharm, Faisalabad 38000, Pakistan.
EM sajidakash@gcuf.du.pk; kanwalakash@gmail.com
RI Rehman, Kanwal/P-7727-2014; Akash, Muhammad Sajid Hamid/C-3477-2018;
   Sabir, Shakila/D-6027-2019
OI Rehman, Kanwal/0000-0001-7873-6681; Akash, Muhammad Sajid
   Hamid/0000-0002-9446-5233; Sabir, Shakila/0000-0002-7233-3731
FU Higher Education Commission (HEC) of Pakistan
   [5661/Punjab/NRPU/RD/HEC/2016, 6429/Punjab/NR-PU/RD/HEC/2016,
   8365/Punjab/NRPU/RD/HEC/2017]
FX This work has been financially supported by the following research
   grants from the Higher Education Commission (HEC) of Pakistan:
   5661/Punjab/NRPU/R&D/HEC/2016, 6429/Punjab/NR-PU/R&D/HEC/2016, and
   8365/Punjab/NRPU/R&D/HEC/2017.
CR Akash MSH, 2013, J CELL BIOCHEM, V114, P525, DOI 10.1002/jcb.24402
   Alhouayek M, 2012, TRENDS MOL MED, V18, P615, DOI 10.1016/j.molmed.2012.07.009
   Alhouayek M, 2011, FASEB J, V25, P2711, DOI 10.1096/fj.10-176602
   Amar J, 2011, DIABETOLOGIA, V54, P3055, DOI 10.1007/s00125-011-2329-8
   Amar J, 2011, EMBO MOL MED, V3, P559, DOI 10.1002/emmm.201100159
   Armougom F, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0007125
   Aronsson L, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0013087
   Asemi Z, 2013, ANN NUTR METAB, V63, P1, DOI 10.1159/000349922
   Backhed F, 2004, P NATL ACAD SCI USA, V101, P15718, DOI 10.1073/pnas.0407076101
   Backhed F, 2005, SCIENCE, V307, P1915, DOI 10.1126/science.1104816
   Backhed F, 2007, P NATL ACAD SCI USA, V104, P979, DOI 10.1073/pnas.0605374104
   Baothman OA, 2016, LIPIDS HEALTH DIS, V15, DOI 10.1186/s12944-016-0278-4
   Barengolts E, 2016, ENDOCR PRACT, V22, P1224, DOI 10.4158/EP151157.RA
   Bergo M, 1996, BIOCHEM J, V313, P893, DOI 10.1042/bj3130893
   Bermudez-Brito M, 2012, ANN NUTR METAB, V61, P160, DOI 10.1159/000342079
   Cani PD, 2007, DIABETOLOGIA, V50, P2374, DOI 10.1007/s00125-007-0791-0
   Cani PD, 2009, GUT, V58, P1091, DOI 10.1136/gut.2008.165886
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   Cani PD, 2009, CURR OPIN PHARMACOL, V9, P737, DOI 10.1016/j.coph.2009.06.016
   Cani PD, 2009, AM J CLIN NUTR, V90, P1236, DOI 10.3945/ajcn.2009.28095
   Chung S, 2006, ENDOCRINOLOGY, V147, P5340, DOI 10.1210/en.2006-0536
   Clarke SF, 2012, GUT MICROBES, V3, P186, DOI 10.4161/gmic.20168
   Clemente JC, 2012, CELL, V148, P1258, DOI 10.1016/j.cell.2012.01.035
   Conlon MA, 2015, NUTRIENTS, V7, P17, DOI 10.3390/nu7010017
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   de La Serre CB, 2010, AM J PHYSIOL-GASTR L, V299, pG440, DOI 10.1152/ajpgi.00098.2010
   Del Chierico F, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.01210
   Delzenne NM, 2015, DIABETOLOGIA, V58, P2206, DOI 10.1007/s00125-015-3712-7
   Deopurkar R, 2010, DIABETES CARE, V33, P991, DOI 10.2337/dc09-1630
   Dewulf EM, 2011, J NUTR BIOCHEM, V22, P712, DOI 10.1016/j.jnutbio.2010.05.009
   Diamant M, 2011, OBES REV, V12, P272, DOI 10.1111/j.1467-789X.2010.00797.x
   Dominguez-Bello MG, 2010, P NATL ACAD SCI USA, V107, P11971, DOI 10.1073/pnas.1002601107
   Dumon Kristoffel, 2014, Evid Based Med, V19, P138, DOI 10.1136/eb-2013-101669
   Eckburg PB, 2005, SCIENCE, V308, P1635, DOI 10.1126/science.1110591
   Ejtahed HS, 2012, NUTRITION, V28, P539, DOI 10.1016/j.nut.2011.08.013
   Enck P, 2016, EXPERT EXCHANGE 2015
   Everard A, 2014, NAT COMMUN, V5, DOI 10.1038/ncomms6648
   Fallucca F, 2015, WORLD J DIABETES, V6, P403, DOI 10.4239/wjd.v6.i3.403
   Fernandez-Real JM, 2003, DIABETES CARE, V26, P1362, DOI 10.2337/diacare.26.5.1362
   Fernandez-Real JM, 2003, ENDOCR REV, V24, P278, DOI 10.1210/er.2002-0010
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Freeland KR, 2010, BRIT J NUTR, V103, P460, DOI 10.1017/S0007114509991863
   Fujimura KE, 2010, EXPERT REV ANTI-INFE, V8, P435, DOI [10.1586/eri.10.14, 10.1586/ERI.10.14]
   Furet JP, 2010, DIABETES, V59, P3049, DOI 10.2337/db10-0253
   Gao J, 2018, FRONT CELL INFECT MI, V8, DOI 10.3389/fcimb.2018.00013
   Ghoshal S, 2009, J LIPID RES, V50, P90, DOI 10.1194/jlr.M800156-JLR200
   Graessler J, 2013, PHARMACOGENOMICS J, V13, P514, DOI 10.1038/tpj.2012.43
   Gupta S, 2016, THER ADV GASTROENTER, V9, P229, DOI 10.1177/1756283X15607414
   Hartstra AV, 2015, DIABETES CARE, V38, P159, DOI 10.2337/dc14-0769
   Kalliomaki M, 2008, AM J CLIN NUTR, V87, P534, DOI 10.1093/ajcn/87.3.534
   Kondo S, 2010, BIOSCI BIOTECH BIOCH, V74, P1656, DOI 10.1271/bbb.100267
   Kootte RS, 2017, CELL METAB, V26, P611, DOI 10.1016/j.cmet.2017.09.008
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Laugerette F, 2011, J NUTR BIOCHEM, V22, P53, DOI 10.1016/j.jnutbio.2009.11.011
   Lee HY, 2006, BBA-MOL CELL BIOL L, V1761, P736, DOI 10.1016/j.bbalip.2006.05.007
   Lewis K, 2010, INFLAMM BOWEL DIS, V16, P1138, DOI 10.1002/ibd.21177
   Ley RE, 2005, P NATL ACAD SCI USA, V102, P11070, DOI 10.1073/pnas.0504978102
   Ley RE, 2006, NATURE, V444, P1022, DOI 10.1038/4441022a
   Louis P, 2009, FEMS MICROBIOL LETT, V294, P1, DOI 10.1111/j.1574-6968.2009.01514.x
   Ma W, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.01336
   Ma X, 2008, J HEPATOL, V49, P821, DOI 10.1016/j.jhep.2008.05.025
   Mandard S, 2006, J BIOL CHEM, V281, P934, DOI 10.1074/jbc.M506519200
   Mehta NN, 2010, DIABETES, V59, P172, DOI 10.2337/db09-0367
   Moya-Perez A, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0126976
   Muccioli GG, 2010, MOL SYST BIOL, V6, DOI 10.1038/msb.2010.46
   Musso G, 2011, ANNU REV MED, V62, P361, DOI 10.1146/annurev-med-012510-175505
   Nagao-Kitamoto H, 2016, INTEST RES, V14, P127, DOI 10.5217/ir.2016.14.2.127
   Pang B, 2015, INT J ENDOCRINOL, V2015, DOI 10.1155/2015/905749
   Parnell JA, 2009, AM J CLIN NUTR, V89, P1751, DOI 10.3945/ajcn.2009.27465
   Peat CM, 2015, EUR EAT DISORD REV, V23, P496, DOI 10.1002/erv.2400
   Philippe D, 2011, WORLD J GASTROENTERO, V17, P459, DOI 10.3748/wjg.v17.i4.459
   Prakash S, 2011, BIOL-TARGETS THER, V5, P71, DOI 10.2147/BTT.S19099
   Preiss-Landl K, 2002, CURR OPIN LIPIDOL, V13, P471, DOI 10.1097/00041433-200210000-00002
   Priebe MG, 2010, AM J CLIN NUTR, V91, P90, DOI 10.3945/ajcn.2009.28521
   Rabot S, 2010, FASEB J, V24, P4948, DOI 10.1096/fj.10-164921
   Rehman K, 2017, J CELL BIOCHEM, V118, P3577, DOI 10.1002/jcb.26097
   Rehman K, 2016, J BIOMED SCI, V23, DOI 10.1186/s12929-016-0303-y
   Riva A, 2017, ENVIRON MICROBIOL, V19, P95, DOI 10.1111/1462-2920.13463
   Roager HM, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-018-05470-4
   Samuel BS, 2008, P NATL ACAD SCI USA, V105, P16767, DOI 10.1073/pnas.0808567105
   Santacruz A, 2010, BRIT J NUTR, V104, P83, DOI 10.1017/S0007114510000176
   Schwiertz A, 2010, OBESITY, V18, P190, DOI 10.1038/oby.2009.167
   Soare A, 2014, NUTR METAB, V11, DOI 10.1186/1743-7075-11-39
   Thuny F, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009074
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Turnbaugh PJ, 2009, NATURE, V457, P480, DOI 10.1038/nature07540
   Usami M, 2008, NUTR RES, V28, P321, DOI 10.1016/j.nutres.2008.02.012
   van Can JGP, 2009, BRIT J NUTR, V102, P1408, DOI 10.1017/S0007114509990687
   Vijay-Kumar M, 2010, SCIENCE, V328, P228, DOI 10.1126/science.1179721
   Viollet B, 2012, CLIN SCI, V122, P253, DOI 10.1042/CS20110386
   Vrieze A, 2010, DIABETOLOGIA, V53, P606, DOI 10.1007/s00125-010-1662-7
   Wall R, 2009, AM J CLIN NUTR, V89, P1393, DOI 10.3945/ajcn.2008.27023
   Wolfe BM, 2016, CIRC RES, V118, P1844, DOI 10.1161/CIRCRESAHA.116.307591
   Wu XK, 2010, CURR MICROBIOL, V61, P69, DOI 10.1007/s00284-010-9582-9
   Yadav H, 2008, J DAIRY RES, V75, P189, DOI 10.1017/S0022029908003129
   Zoetendal EG, 2006, MOL MICROBIOL, V59, P1639, DOI 10.1111/j.1365-2958.2006.05056.x
NR 97
TC 16
Z9 17
U1 1
U2 13
PU BEGELL HOUSE INC
PI DANBURY
PA 50 NORTH ST, DANBURY, CT 06810 USA
SN 1040-8401
EI 2162-6472
J9 CRIT REV IMMUNOL
JI Crit. Rev. Immunol.
PY 2019
VL 39
IS 4
BP 223
EP 237
DI 10.1615/CritRevImmunol.2019030614
PG 15
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA KF8AZ
UT WOS:000509461000001
PM 32421966
DA 2023-06-08
ER

PT J
AU Kangwan, N
   Pratchayasakul, W
   Kongkaew, A
   Pintha, K
   Chattipakorn, N
   Chattipakorn, SC
AF Kangwan, Napapan
   Pratchayasakul, Wasana
   Kongkaew, Aphisek
   Pintha, Komsak
   Chattipakorn, Nipon
   Chattipakorn, Siriporn C.
TI Perilla Seed Oil Alleviates Gut Dysbiosis, Intestinal Inflammation and
   Metabolic Disturbance in Obese-Insulin-Resistant Rats
SO NUTRIENTS
LA English
DT Article
DE gut microbiota; omega-3 fatty acids; inflammation; insulin resistance;
   systemic inflammation
ID HIGH-FAT DIET; METFORMIN; MICROBIOTA; ENDOTOXEMIA; DISEASE
AB Background: High-fat diet (HFD) consumption induced gut dysbiosis, inflammation, obese-insulin resistance. Perilla seed oil (PSO) is a rich source of omega-3 polyunsaturated fatty acids with health promotional effects. However, the effects of PSO on gut microbiota/inflammation and metabolic disturbance in HFD-induced obesity have not been investigated. Therefore, we aimed to compare the effects of different doses of PSO and metformin on gut microbiota/inflammation, and metabolic parameters in HFD-fed rats. Methods: Thirty-six male Wistar rats were fed either a normal diet or an HFD for 24 weeks. At week 13, HFD-fed rats received either 50, 100, and 500 mg/kg/day of PSO or 300 mg/kg/day metformin for 12 weeks. After 24 weeks, the metabolic parameters, gut microbiota, gut barrier, inflammation, and oxidative stress were determined. Results: HFD-fed rats showed gut dysbiosis, gut barrier disruption with inflammation, increased oxidative stress, metabolic endotoxemia, and insulin resistance. Treatment with PSO and metformin not only effectively attenuated gut dysbiosis, but also improved gut barrier integrity and decreased gut inflammation. PSO also decreased oxidative stress, metabolic endotoxemia, and insulin resistance in HFD-fed rats. Metformin had greater benefits than PSO. Conclusion: PSO and metformin had the beneficial effect on attenuating gut inflammation and metabolic disturbance in obese-insulin resistance.
C1 [Kangwan, Napapan] Univ Phayao, Sch Med Sci, Div Physiol, Phayao 56000, Thailand.
   [Pratchayasakul, Wasana; Chattipakorn, Nipon; Chattipakorn, Siriporn C.] Chiang Mai Univ, Fac Med, Cardiac Electrophysiol Res & Training Ctr, Neurophysiol Unit, Chiang Mai 50200, Thailand.
   [Pratchayasakul, Wasana; Chattipakorn, Nipon; Chattipakorn, Siriporn C.] Chiang Mai Univ, Fac Med, Dept Physiol, Cardiac Electrophysiol Unit, Chiang Mai 50200, Thailand.
   [Pratchayasakul, Wasana; Chattipakorn, Nipon; Chattipakorn, Siriporn C.] Chiang Mai Univ, Ctr Excellence Cardiac Electrophysiol Res, Chiang Mai 50200, Thailand.
   [Kongkaew, Aphisek] Chiang Mai Univ, Fac Med, Res Adm Sect, Chiang Mai 50200, Thailand.
   [Pintha, Komsak] Univ Phayao, Sch Med Sci, Dept Biochem, Phayao 56000, Thailand.
   [Chattipakorn, Siriporn C.] Chiang Mai Univ, Fac Dent, Dept Oral Biol & Diagnost Sci, Chiang Mai 50200, Thailand.
C3 University of Phayao; Chiang Mai University; Chiang Mai University;
   Chiang Mai University; Chiang Mai University; University of Phayao;
   Chiang Mai University
RP Chattipakorn, SC (通讯作者)，Chiang Mai Univ, Fac Med, Cardiac Electrophysiol Res & Training Ctr, Neurophysiol Unit, Chiang Mai 50200, Thailand.; Chattipakorn, SC (通讯作者)，Chiang Mai Univ, Fac Med, Dept Physiol, Cardiac Electrophysiol Unit, Chiang Mai 50200, Thailand.; Chattipakorn, SC (通讯作者)，Chiang Mai Univ, Ctr Excellence Cardiac Electrophysiol Res, Chiang Mai 50200, Thailand.; Chattipakorn, SC (通讯作者)，Chiang Mai Univ, Fac Dent, Dept Oral Biol & Diagnost Sci, Chiang Mai 50200, Thailand.
EM napapan.kangwan@gmail.com; wpratchayasakul@gmail.com;
   moromo046@gmail.com; komsakjo@gmail.com; nchattip@gmail.com;
   siriporn.c@cmu.ac.th
OI Kangwan, Napapan/0000-0002-9184-7850; Chattipakorn,
   Siriporn/0000-0003-1677-7052; Chattipakorn, Nipon/0000-0003-3026-718X
FU Thailand Research Fund [MRG6280240]; Office of the Higher Education
   Commission [MRG6280240]; Thailand Science Research and Innovation Fund
   [FF64-UoE034]; University of Phayao [FF64-UoE034]; National Research
   Council of Thailand; National Research Council of Thailand (NRCT); NSTDA
   Research Chair Grant from the National Science and Technology
   Development Agency Thailand; Chiang Mai University Excellence Center
   Award
FX This research was supported by the Thailand Research Fund and Office of
   the Higher Education Commission, grant number MRG6280240 (N.K.); the
   Thailand Science Research and Innovation Fund and the University of
   Phayao, grant number FF64-UoE034 (N.K.); a Senior Research Scholar grant
   from the National Research Council of Thailand (to S.C.C.); the National
   Research Council of Thailand (NRCT, toW.P.); an NSTDA Research Chair
   Grant from the National Science and Technology Development Agency
   Thailand (N.C.); and a Chiang Mai University Excellence Center Award (to
   N.C.).
CR Adeshirlarijaney A, 2019, AM J PHYSIOL-ENDOC M, V317, pE1121, DOI 10.1152/ajpendo.00245.2019
   Asif M, 2011, ORIENTAL PHARM EXP M, V11, P51, DOI 10.1007/s13596-011-0002-x
   Bae SJ, 2020, MOLECULES, V25, DOI 10.3390/molecules25112662
   Belkaid Y, 2014, CELL, V157, P121, DOI 10.1016/j.cell.2014.03.011
   Bluher M, 2019, NAT REV ENDOCRINOL, V15, P288, DOI 10.1038/s41574-019-0176-8
   Boulange CL, 2016, GENOME MED, V8, DOI 10.1186/s13073-016-0303-2
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Chen FM, 2020, OXID MED CELL LONGEV, V2020, DOI 10.1155/2020/6028606
   Chunchai T, 2018, J NEUROINFLAMM, V15, DOI 10.1186/s12974-018-1055-2
   Cui CX, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0186216
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   de la Monte SM, 2009, BMB REP, V42, P475, DOI 10.5483/BMBRep.2009.42.8.475
   DeFronzo R, 2016, METABOLISM, V65, P20, DOI 10.1016/j.metabol.2015.10.014
   DeGruttola AK, 2016, INFLAMM BOWEL DIS, V22, P1137, DOI 10.1097/MIB.0000000000000750
   Ding SL, 2011, CURR OPIN CLIN NUTR, V14, P328, DOI 10.1097/MCO.0b013e3283478727
   Ding SL, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0012191
   Fei N, 2013, ISME J, V7, P880, DOI 10.1038/ismej.2012.153
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Hashimoto M, 2020, FOODS, V9, DOI 10.3390/foods9040530
   Hildebrandt MA, 2009, GASTROENTEROLOGY, V137, P1716, DOI 10.1053/j.gastro.2009.08.042
   Kamalashiran C, 2018, J AGING RES, V2018, DOI 10.1155/2018/5302105
   Kangwan N, 2021, RES PHARM SCI, V16, P464, DOI 10.4103/1735-5362.323913
   Kim KA, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0047713
   Kim SR, 2019, J MED FOOD, V22, P14, DOI 10.1089/jmf.2018.4226
   Krajmalnik-Brown R, 2012, NUTR CLIN PRACT, V27, P201, DOI 10.1177/0884533611436116
   Lee H, 2018, GUT MICROBES, V9, P155, DOI 10.1080/19490976.2017.1405209
   Lee HC, 2019, FOOD FUNCT, V10, P786, DOI 10.1039/c8fo02423e
   Liu HQ, 2013, NUTR RES, V33, P849, DOI 10.1016/j.nutres.2013.07.004
   Mohammad S, 2021, FRONT IMMUNOL, V11, DOI 10.3389/fimmu.2020.594150
   Murphy EA, 2015, CURR OPIN CLIN NUTR, V18, P515, DOI 10.1097/MCO.0000000000000209
   Muscogiuri Giovanna, 2019, Int J Obes Suppl, V9, P10, DOI 10.1038/s41367-019-0011-7
   Pendyala S, 2012, GASTROENTEROLOGY, V142, P1100, DOI 10.1053/j.gastro.2012.01.034
   Pintana H, 2012, LIFE SCI, V91, P409, DOI 10.1016/j.lfs.2012.08.017
   Rohr MW, 2020, ADV NUTR, V11, P77, DOI 10.1093/advances/nmz061
   Saiyasit N, 2020, NUTRITION, V69, DOI 10.1016/j.nut.2019.110576
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Shin W, 2018, P NATL ACAD SCI USA, V115, pE10539, DOI 10.1073/pnas.1810819115
   Thambisetty M, 2013, JAMA NEUROL, V70, P1167, DOI 10.1001/jamaneurol.2013.284
   Thiennimitr P, 2018, NUTRITION, V54, P40, DOI 10.1016/j.nut.2018.03.005
   Thomas SS, 2020, NUTR RES PRACT, V14, P425, DOI 10.4162/nrp.2020.14.5.425
   Thomas SS, 2020, J MED FOOD, V23, P818, DOI 10.1089/jmf.2019.4675
   Tian Y, 2016, BIOMED RES INT, V2016, DOI 10.1155/2016/9462571
   Todorov H, 2020, NUTRIENTS, V12, DOI 10.3390/nu12030732
   Tunapong W, 2018, EUR J NUTR, V57, P2091, DOI 10.1007/s00394-017-1482-3
   Wang F, 2021, NUTR DIABETES, V11, DOI 10.1038/s41387-021-00159-y
   Wang F, 2018, MOL NUTR FOOD RES, V62, DOI 10.1002/mnfr.201800299
   Wang JK, 2020, FOOD CHEM TOXICOL, V135, DOI 10.1016/j.fct.2019.110965
   Wang YW, 2017, DRUG DES DEV THER, V11, P2421, DOI 10.2147/DDDT.S141675
   Weersma RK, 2020, GUT, V69, P1510, DOI 10.1136/gutjnl-2019-320204
   Wei MG, 2013, J TRADIT CHIN MED, V33, P170, DOI 10.1016/S0254-6272(13)60120-X
   Winter SE, 2010, NATURE, V467, P426, DOI 10.1038/nature09415
   Zhang Q, 2020, DIABET METAB SYND OB, V13, P5003, DOI 10.2147/DMSO.S286430
   Zhang X, 2015, SCI REP-UK, V5, DOI 10.1038/srep14405
   Zhou ZY, 2016, ACTA PHARMACOL SIN, V37, P1063, DOI 10.1038/aps.2016.21
NR 54
TC 7
Z9 7
U1 3
U2 17
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD SEP
PY 2021
VL 13
IS 9
AR 3141
DI 10.3390/nu13093141
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA UX8PJ
UT WOS:000701100000001
PM 34579018
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Jacobi, O
   Landman, Y
   Reinhorn, D
   Icht, O
   Sternschuss, M
   Rotem, O
   Finkel, I
   Allen, AM
   Dudnik, E
   Goldstein, DA
   Zer, A
AF Jacobi, Oded
   Landman, Yosef
   Reinhorn, Daniel
   Icht, Oded
   Sternschuss, Michal
   Rotem, Ofer
   Finkel, Inbar
   Allen, Aaron M.
   Dudnik, Elizabeth
   Goldstein, Daniel A.
   Zer, Alona
TI The Relationship of Diabetes Mellitus to Efficacy of Immune Checkpoint
   Inhibitors in Patients with Advanced Non-Small Cell Lung Cancer
SO ONCOLOGY
LA English
DT Article
DE Non-small cell lung cancer; Metformin; Diabetes; Immune checkpoint
   inhibitors; Immunotherapy
ID GUT MICROBIOME; METFORMIN; SURVIVAL; CHEMOTHERAPY; METAANALYSIS;
   PREVENTION; RESPONSES; DRUG
AB Introduction: Immune checkpoint inhibitors (ICI) are the new standard therapy in patients with metastatic NSCLC (mNSCLC). Metformin, previously associated with improved chemotherapy efficacy in diabetic and nondiabetic cancer patients, was recently associated with increased ICI efficacy. In this study, we aimed to explore the correlations between diabetes mellitus (DM), metformin use, and benefit from ICI in mNSCLC patients. Methods: All mNSCLC patients treated with ICI in our center between February 2015 and April 2018 were identified. Demographic and clinical data were extracted retrospectively. Cox proportional hazards regression, t tests, and chi(2) tests were employed to evaluate associations of progression-free survival (PFS), overall survival (OS), overall response rate (ORR), and disease control rate (DCR), with DM status, metformin use, and HbA1c levels, as appropriate. Results: Of 249 mNSCLC patients treated with ICI, 57 (22.8%) had DM. Thirty-seven (64.9% of all diabetic patients) patients were treated with metformin. A significant negative correlation of DM with PFS and OS was demonstrated (HR 1.5 [1.01-2.06], p = 0.011, and HR 1.5 [1.08-2.08], p = 0.017, respectively). Metformin exposure had no significant correlation with PFS or OS in diabetic mNSCLC patients (HR 1.08 [0.61-1.93], p = 0.79, and HR 1.29 [0.69-2.39], p = 0.42, respectively). There were no differences between groups with respect to ORR and DCR. Conclusion: Our data show a potential negative relationship between DM and ICI efficacy in mNSCLC patients. In contrast to reports with chemotherapy, we found no positive relationship between metformin use and ICI therapy in diabetic patients with mNSCLC. Further studies are needed to evaluate the effect of metformin in nondiabetic mNSCLC patients.
C1 [Jacobi, Oded; Landman, Yosef; Reinhorn, Daniel; Icht, Oded; Sternschuss, Michal; Rotem, Ofer; Finkel, Inbar; Allen, Aaron M.; Dudnik, Elizabeth; Goldstein, Daniel A.; Zer, Alona] Rabin Med Ctr, Davidoff Canc Ctr, Petah Tiqwa, Israel.
C3 Rabin Medical Center
RP Jacobi, O (通讯作者)，Rabin Med Ctr, Davidoff Canc Ctr, Petah Tiqwa, Israel.
EM jacobi.oded@gmail.com
OI Jacobi, Oded/0000-0002-0825-2160
CR Arrieta O, 2019, JAMA ONCOL, V5, DOI 10.1001/jamaoncol.2019.2553
   Cao X, 2017, J CANCER, V8, P2532, DOI 10.7150/jca.19750
   Daugan M, 2016, PHARMACOL RES, V113, P675, DOI 10.1016/j.phrs.2016.10.006
   Delamaire M, 1997, DIABETIC MED, V14, P29, DOI 10.1002/(SICI)1096-9136(199701)14:1<29::AID-DIA300>3.0.CO;2-V
   Eikawa S, 2015, P NATL ACAD SCI USA, V112, P1809, DOI 10.1073/pnas.1417636112
   Gandini S, 2014, CANCER PREV RES, V7, P867, DOI 10.1158/1940-6207.CAPR-13-0424
   Garon EB, 2019, J CLIN ONCOL, V37, DOI 10.1200/JCO.19.00934
   Geerlings SE, 1999, FEMS IMMUNOL MED MIC, V26, P259, DOI 10.1016/S0928-8244(99)00142-X
   Granier C, 2017, ESMO OPEN, V2, DOI 10.1136/esmoopen-2017-000213
   Havel JJ, 2019, NAT REV CANCER, V19, P133, DOI 10.1038/s41568-019-0116-x
   Huang CY, 2017, BIOMEDICINE-TAIWAN, V7, P12, DOI 10.1051/bmdcn/2017070423
   Jiralerspong S, 2009, J CLIN ONCOL, V27, P3297, DOI 10.1200/JCO.2009.19.6410
   Kim SH, 2017, J INVEST DERMATOL, V137, P1740, DOI 10.1016/j.jid.2017.03.033
   Ko EM, 2014, GYNECOL ONCOL, V132, P438, DOI 10.1016/j.ygyno.2013.11.021
   Kroemer G., 2019, NAT REV CLIN ONCOL
   Kumar S, 2013, CANCER-AM CANCER SOC, V119, P555, DOI 10.1002/cncr.27706
   Maniar K, 2017, PHARMACOL RES, V117, P103, DOI 10.1016/j.phrs.2016.12.003
   Marrone KA, 2018, ONCOLOGIST, V23, P859, DOI 10.1634/theoncologist.2017-0465
   Matson V, 2018, SCIENCE, V359, P104, DOI 10.1126/science.aao3290
   Mazade MA, 2001, MOL GENET METAB, V73, P259, DOI 10.1006/mgme.2001.3185
   Price CL, 2010, J CELL MOL MED, V14, P1806, DOI 10.1111/j.1582-4934.2009.00803.x
   Quinn BJ, 2013, TRENDS ENDOCRIN MET, V24, P469, DOI 10.1016/j.tem.2013.05.004
   Romero R, 2017, AM J OBSTET GYNECOL, V217, P282, DOI 10.1016/j.ajog.2017.06.003
   Scharping NE, 2017, CANCER IMMUNOL RES, V5, P9, DOI 10.1158/2326-6066.CIR-16-0103
   Shachar SS, 2018, J CLIN ONCOL, V36
   Sivan A, 2015, SCIENCE, V350, P1084, DOI 10.1126/science.aac4255
   STUMVOLL M, 1995, NEW ENGL J MED, V333, P550, DOI 10.1056/NEJM199508313330903
   Wang JC, 2018, J CELL MOL MED, V22, P3825, DOI 10.1111/jcmm.13655
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Zykova SN, 2000, DIABETES, V49, P1451, DOI 10.2337/diabetes.49.9.1451
NR 30
TC 8
Z9 8
U1 0
U2 9
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0030-2414
EI 1423-0232
J9 ONCOLOGY-BASEL
JI Oncology
PD AUG
PY 2021
VL 99
IS 9
BP 555
EP 561
DI 10.1159/000516671
EA JUL 2021
PG 7
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA UK7MG
UT WOS:000672820400001
PM 34247166
DA 2023-06-08
ER

PT J
AU Allin, KH
   Tremaroli, V
   Caesar, R
   Jensen, BAH
   Damgaard, MTF
   Bahl, MI
   Licht, TR
   Hansen, TH
   Nielsen, T
   Dantoft, TM
   Linneberg, A
   Jorgensen, T
   Vestergaard, H
   Kristiansen, K
   Franks, PW
   Hansen, T
   Backhed, F
   Pedersen, O
AF Allin, Kristine H.
   Tremaroli, Valentina
   Caesar, Robert
   Jensen, Benjamin A. H.
   Damgaard, Mads T. F.
   Bahl, Martin I.
   Licht, Tine R.
   Hansen, Tue H.
   Nielsen, Trine
   Dantoft, Thomas M.
   Linneberg, Allan
   Jorgensen, Torben
   Vestergaard, Henrik
   Kristiansen, Karsten
   Franks, Paul W.
   Hansen, Torben
   Backhed, Fredrik
   Pedersen, Oluf
CA IMI-DIRECT Consortium
TI Aberrant intestinal microbiota in individuals with prediabetes
SO DIABETOLOGIA
LA English
DT Article
DE Akkermansia muciniphila; Clostridium; Faecal transfer; Gut microbiota;
   Hyperglycaemia; Intestinal microbiota; Low-grade inflammation;
   Prediabetes
ID HUMAN GUT MICROBIOME; AKKERMANSIA-MUCINIPHILA; METFORMIN; METAGENOME;
   BACTERIA; HEALTH; MUCIN
AB Aims/hypothesis Individuals with type 2 diabetes have aberrant intestinal microbiota. However, recent studies suggest that metformin alters the composition and functional potential of gut microbiota, thereby interfering with the diabetes-related microbial signatures. We tested whether specific gut microbiota profiles are associated with prediabetes (defined as fasting plasma glucose of 6.1-7.0 mmol/l or HbA(1c) of 42-48 mmol/mol [6.0-6.5%]) and a range of clinical biomarkers of poor metabolic health.
   Methods In the present case-control study, we analysed the gut microbiota of 134 Danish adults with prediabetes, overweight, insulin resistance, dyslipidaemia and low-grade inflammation and 134 age-and sex-matched individuals with normal glucose regulation.
   Results We found that five bacterial genera and 36 operational taxonomic units (OTUs) were differentially abundant between individuals with prediabetes and those with normal glucose regulation. At the genus level, the abundance of Clostridium was decreased (mean log(2) fold change -0.64 (SEM 0.23), p(adj) = 0.0497), whereas the abundances of Dorea, [ Ruminococcus], Sutterella and Streptococcus were increased (mean log(2) fold change 0.51 (SEM 0.12), p(adj) = 5 x 10(-4); 0.51 (SEM 0.11), p(adj) = 1 x 10-4; 0.60 (SEM 0.21), p(adj) = 0.0497; and 0.92 (SEM0.21), padj = 4 x 10(-4), respectively). The two OTUs that differed the most were a member of the order Clostridiales (OTU 146564) and Akkermansia muciniphila, which both displayed lower abundance among individuals with prediabetes (mean log(2) fold change -1.74 (SEM0.41), p(adj) = 2 x 10(-3) and -1.65 (SEM0.34), p(adj) = 4 x 10(-4), respectively). Faecal transfer from donors with prediabetes or screen-detected, drug-naive type 2 diabetes to germfree Swiss Webster or conventional C57BL/6 J mice did not induce impaired glucose regulation in recipient mice.
   Conclusions/interpretation Collectively, our data show that individuals with prediabetes have aberrant intestinal microbiota characterised by a decreased abundance of the genus Clostridium and the mucin-degrading bacterium A. muciniphila. Our findings are comparable to observations in overt chronic diseases characterised by low-grade inflammation.
C1 [Allin, Kristine H.; Hansen, Tue H.; Nielsen, Trine; Vestergaard, Henrik; Hansen, Torben; Pedersen, Oluf] Univ Copenhagen, Fac Hlth & Med Sci, Sect Metab Genet, Novo Nordisk Fdn Ctr Basic Metab Res, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark.
   [Allin, Kristine H.] Bispebjerg & Frederiksberg Hosp, Dept Clin Epidemiol, Copenhagen, Denmark.
   [Tremaroli, Valentina; Caesar, Robert; Backhed, Fredrik] Univ Gothenburg, Dept Mol & Clin Med, Wallenberg Lab, SE-41345 Gothenburg, Sweden.
   [Tremaroli, Valentina; Caesar, Robert; Backhed, Fredrik] Univ Gothenburg, Sahlgrenska Ctr Cardiovasc & Metab Res, Gothenburg, Sweden.
   [Jensen, Benjamin A. H.; Damgaard, Mads T. F.; Kristiansen, Karsten] Univ Copenhagen, Dept Biol, Lab Genom & Mol Biomed, Fac Sci, Copenhagen, Denmark.
   [Bahl, Martin I.; Licht, Tine R.] Tech Univ Denmark, Natl Food Inst, Lyngby, Denmark.
   [Dantoft, Thomas M.; Linneberg, Allan; Jorgensen, Torben] Capital Reg Denmark, Res Ctr Prevent & Hlth, Copenhagen, Denmark.
   [Linneberg, Allan] Rigshosp, Dept Clin Expt Res, Glostrup, Denmark.
   [Jorgensen, Torben] Univ Copenhagen, Fac Hlth & Med Sci, Dept Publ Hlth, Copenhagen, Denmark.
   [Jorgensen, Torben] Aalborg Univ, Fac Med, Aalborg, Denmark.
   [Vestergaard, Henrik] Steno Diabet Ctr Copenhagen, Gentofte, Denmark.
   [Franks, Paul W.] Lund Univ, Dept Clin Sci, Genet & Mol Epidemiol Unit, Malmo, Sweden.
   [Franks, Paul W.] Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden.
   [Franks, Paul W.] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA.
   [Hansen, Torben] Univ Southern Denmark, Fac Hlth Sci, Odense, Denmark.
   [Backhed, Fredrik] Univ Copenhagen, Fac Hlth & Med Sci, Sect Metab Receptol & Enteroendocrinol, Novo Nordisk Fdn Ctr Basic Metab Res, Copenhagen, Denmark.
   [Pedersen, Oluf] Univ Aarhus, Fac Hlth Sci, Aarhus, Denmark.
C3 Novo Nordisk Foundation; University of Copenhagen; University of
   Copenhagen; Bispebjerg Hospital; University of Gothenburg; University of
   Gothenburg; University of Copenhagen; Technical University of Denmark;
   Rigshospitalet; University of Copenhagen; Aalborg University; Steno
   Diabetes Center; Lund University; Umea University; Harvard University;
   Harvard T.H. Chan School of Public Health; University of Southern
   Denmark; Novo Nordisk Foundation; University of Copenhagen; Aarhus
   University
RP Allin, KH; Pedersen, O (通讯作者)，Univ Copenhagen, Fac Hlth & Med Sci, Sect Metab Genet, Novo Nordisk Fdn Ctr Basic Metab Res, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark.; Allin, KH (通讯作者)，Bispebjerg & Frederiksberg Hosp, Dept Clin Epidemiol, Copenhagen, Denmark.; Tremaroli, V (通讯作者)，Univ Gothenburg, Dept Mol & Clin Med, Wallenberg Lab, SE-41345 Gothenburg, Sweden.; Tremaroli, V (通讯作者)，Univ Gothenburg, Sahlgrenska Ctr Cardiovasc & Metab Res, Gothenburg, Sweden.; Pedersen, O (通讯作者)，Univ Aarhus, Fac Hlth Sci, Aarhus, Denmark.
EM kristine.allin@regionh.dk; Valentina.Tremaroli@wlab.gu.se;
   oluf@sund.ku.dk
RI Dantoft, Thomas Meinertz/N-2702-2017; Franks, Paul/AAA-3300-2020;
   Kristiansen, Karsten/J-5148-2014; Nielsen, trine/HJZ-4867-2023; Caesar,
   Robert/AAX-3205-2020; Jensen, Benjamin A. H./M-4661-2014; Hansen, Tue
   Haldor/S-7724-2016; Backhed, Fredrik/ABE-6613-2020; Allin, Kristine
   Højgaard/ABG-3463-2021; Jørgensen, Torben/Z-1335-2018; Pedersen,
   Oluf/Z-1731-2019; Tremaroli, Valentina/AAE-8001-2019; Pedersen,
   Oluf/AAG-8015-2020
OI Dantoft, Thomas Meinertz/0000-0001-7437-7052; Kristiansen,
   Karsten/0000-0002-6024-0917; Nielsen, trine/0000-0002-2066-7895; Jensen,
   Benjamin A. H./0000-0001-6991-0828; Hansen, Tue
   Haldor/0000-0001-5948-8993; Backhed, Fredrik/0000-0002-4871-8818;
   Pedersen, Oluf/0000-0002-3321-3972; Tremaroli,
   Valentina/0000-0002-9150-4233; Licht, Tine Rask/0000-0002-6399-9574;
   Hansen, Torben/0000-0001-8748-3831; Franks, Paul/0000-0002-0520-7604;
   Damgaard, Mads Vargas/0000-0001-8488-2298; Bahl, Martin
   Iain/0000-0003-1579-8038; Linneberg, Allan/0000-0002-0994-0184;
   Jorgensen, Torben/0000-0001-9453-2830; Vestergaard,
   Henrik/0000-0003-3090-269X; Allin, Kristine Hojgaard/0000-0002-6880-5759
FU TrygFonden [7-11-0213]; Novo Nordisk Foundation [NNF15OC0015896]; Danish
   Council for Independent Research \ Medical Sciences; Innovative
   Medicines Initiative Joint Undertaking under European Union's Seventh
   Framework Programme (FP7) [115317]; Lundbeck Foundation
   [R155-2013-14070]; Danish Diabetes Association; EFPIA companies;
   Lundbeck Foundation [R155-2013-14070] Funding Source: researchfish
FX KHA is supported by grants from The Danish Council for Independent
   Research vertical bar Medical Sciences and the Danish Diabetes
   Association. The work leading to this publication has received support
   from the Innovative Medicines Initiative Joint Undertaking under grant
   agreement no. 115317 (DIRECT), resources of which are composed of
   financial contribution from the European Union's Seventh Framework
   Programme (FP7/2007-2013) and EFPIA companies' in kind contribution. The
   DanFunD was supported by TrygFonden (7-11-0213), the Lundbeck Foundation
   (R155-2013-14070) and the Novo Nordisk Foundation (NNF15OC0015896). The
   Novo Nordisk Foundation Center for Basic Metabolic Research is an
   independent research centre at the University of Copenhagen that is
   partially funded by an unrestricted donation from the Novo Nordisk
   Foundation. The funding sources had no role in the study design, data
   collection, data analysis, data interpretation or writing of the
   manuscript.
CR Amer Diabet Assoc, 2014, DIABETES CARE, V37, pS81, DOI [10.2337/dc13-S067, 10.2337/dc14-S081, 10.2337/dc13-S011, 10.2337/dc10-S062, 10.2337/dc10-S011, 10.2337/dc11-S062, 10.2337/dc12-s064, 10.2337/dc11-S011]
   Anderson MJ, 2001, AUSTRAL ECOL, V26, P32, DOI 10.1046/j.1442-9993.2001.01070.x
   Backhed F, 2015, CELL HOST MICROBE, V17, P690, DOI [10.1016/j.chom.2015.04.004, 10.1016/j.chom.2015.05.012]
   Best D. J., 1975, Applied Statistics, V24, P377, DOI 10.2307/2347111
   Candela M, 2012, BMC MICROBIOL, V12, DOI 10.1186/1471-2180-12-95
   Caporaso JG, 2010, NAT METHODS, V7, P335, DOI 10.1038/nmeth.f.303
   Caporaso JG, 2010, BIOINFORMATICS, V26, P266, DOI 10.1093/bioinformatics/btp636
   Chen HM, 2013, AM J CLIN NUTR, V97, P1044, DOI 10.3945/ajcn.112.046607
   Chung HC, 2012, CELL, V149, P1578, DOI 10.1016/j.cell.2012.04.037
   Damgaard MTF, 2018, J NUTR BIOCHEM, V54, P66, DOI 10.1016/j.jnutbio.2017.09.026
   Dantoft TM, 2017, CLIN EPIDEMIOL, V9, P127, DOI 10.2147/CLEP.S129335
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   John WG, 2012, DIABETIC MED, V29, P1350, DOI 10.1111/j.1464-5491.2012.03762.x
   Jonsson AL, 2017, NAT REV CARDIOL, V14, P79, DOI 10.1038/nrcardio.2016.183
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Koivula Robert W, 2014, Diabetologia, V57, P1132, DOI 10.1007/s00125-014-3216-x
   Kozich JJ, 2013, APPL ENVIRON MICROB, V79, P5112, DOI 10.1128/AEM.01043-13
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Le Chatelier E, 2013, NATURE, V500, P541, DOI 10.1038/nature12506
   Liu RX, 2017, NAT MED, V23, P859, DOI 10.1038/nm.4358
   Love MI, 2014, GENOME BIOL, V15, DOI 10.1186/s13059-014-0550-8
   Lynch SV, 2016, NEW ENGL J MED, V375, P2369, DOI 10.1056/NEJMra1600266
   McCarthy MI, 2010, NEW ENGL J MED, V363, P2339, DOI 10.1056/NEJMra0906948
   McMurdie PJ, 2014, PLOS COMPUT BIOL, V10, DOI 10.1371/journal.pcbi.1003531
   Org E, 2017, GENOME BIOL, V18, DOI 10.1186/s13059-017-1194-2
   Plovier H, 2017, NAT MED, V23, P107, DOI 10.1038/nm.4236
   Png CW, 2010, AM J GASTROENTEROL, V105, P2420, DOI 10.1038/ajg.2010.281
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Sato J, 2014, DIABETES CARE, V37, P2343, DOI 10.2337/dc13-2817
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Tabak AG, 2012, LANCET, V379, P2279, DOI 10.1016/S0140-6736(12)60283-9
   Tremaroli V, 2015, CELL METAB, V22, P228, DOI 10.1016/j.cmet.2015.07.009
   Wahlstrom A, 2017, J LIPID RES, V58, P412, DOI 10.1194/jlr.M072819
   World Health Organization, 2006, DEF DIAGN DIAB MELL
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Zhang JJ, 2014, BIOINFORMATICS, V30, P614, DOI 10.1093/bioinformatics/btt593
   Zhang L, 2017, ISME J, V11, P676, DOI 10.1038/ismej.2016.151
   Zhang XY, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0071108
NR 40
TC 215
Z9 233
U1 10
U2 86
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0012-186X
EI 1432-0428
J9 DIABETOLOGIA
JI Diabetologia
PD APR
PY 2018
VL 61
IS 4
BP 810
EP 820
DI 10.1007/s00125-018-4550-1
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA FY7NL
UT WOS:000427049100009
PM 29379988
OA Green Published, hybrid
HC Y
HP N
DA 2023-06-08
ER

PT J
AU Merkevicius, K
   Kundelis, R
   Maleckas, A
   Velickiene, D
AF Merkevicius, Kajus
   Kundelis, Ricardas
   Maleckas, Almantas
   Velickiene, Dzilda
TI Microbiome Changes after Type 2 Diabetes Treatment: A Systematic Review
SO MEDICINA-LITHUANIA
LA English
DT Review
DE type 2 diabetes; gut microbiome; bariatric surgery; probiotics;
   prebiotics; synbiotics
ID HUMAN GUT MICROBIOME; BARIATRIC SURGERY; AKKERMANSIA-MUCINIPHILA;
   GASTRIC BYPASS; DOUBLE-BLIND; WEIGHT-LOSS; BILE-ACIDS; PROBIOTICS;
   METFORMIN; BACTERIA
AB Background and objectives: Although the role of the gut microbiome in type 2 diabetes (T2D) pathophysiology is evident, current systematic reviews and meta-analyses analyzing T2D treatment mainly focus on metabolic outcomes. The objective of this study is to evaluate the microbiome and metabolic changes after different types of treatment in T2D patients. Materials and Methods: A systematic search of PubMed, Wiley online library, Science Direct, and Cochrane library electronic databases was performed. Randomized controlled clinical trials published in the last five years that included T2D subjects and evaluated the composition of the gut microbiome alongside metabolic outcomes before and after conventional or alternative glucose lowering therapy were selected. Microbiome changes were evaluated alongside metabolic outcomes in terms of bacteria taxonomic hierarchy, intestinal flora biodiversity, and applied intervention. Results: A total of 16 eligible studies involving 1301 participants were reviewed. Four trials investigated oral glucose-lowering treatment, three studies implemented bariatric surgery, and the rest analyzed probiotic, prebiotic, or synbiotic effects. The most common alterations were increased abundance of Firmicutes and Proteobacteria parallel to improved glycemic control. Bariatric surgery, especially Roux-en-Y gastric bypass, led to the highest variety of changed bacteria phyla. Lower diversity post-treatment was the most significant biodiversity result, which was present with improved glycemic control. Conclusions: Anti-diabetic treatment induced the growth of depleted bacteria. A gut microbiome similar to healthy individuals was achieved during some trials. Further research must explore the most effective strategies to promote beneficial bacteria, lower diversity, and eventually reach a non-T2D microbiome.</p>
C1 [Merkevicius, Kajus; Kundelis, Ricardas] Vilnius Univ, Fac Med, LT-03101 Vilnius, Lithuania.
   [Maleckas, Almantas] Lithuanian Univ Hlth Sci, Med Acad, Dept Surg, LT-50009 Kaunas, Lithuania.
   [Maleckas, Almantas] Univ Gothenburg, Sahlgrenska Acad, Inst Clin Sci, Dept Surg, S-40530 Gothenburg, Sweden.
   [Velickiene, Dzilda] Lithuanian Univ Hlth Sci, Inst Endocrinol, LT-50009 Kaunas, Lithuania.
C3 Vilnius University; Lithuanian University of Health Sciences; University
   of Gothenburg; Lithuanian University of Health Sciences
RP Merkevicius, K (通讯作者)，Vilnius Univ, Fac Med, LT-03101 Vilnius, Lithuania.
EM kajus.merkevicius@gmail.com; ricardas.kundelis@gmail.com;
   almantas.maleckas@lsmu.it; Dzilda.Velickiene@lsmuni.it
RI Merkevicius, Kajus/ACW-8165-2022
OI Merkevicius, Kajus/0000-0002-0480-3922; Kundelis,
   Ricardas/0000-0001-9588-0474
CR Akbari V, 2016, NUTR REV, V74, P774, DOI 10.1093/nutrit/nuw039
   Aliasgharzadeh A, 2015, ADV PHARM BULL, V5, P507, DOI 10.15171/apb.2015.069
   Ammar EM, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-017-18704-0
   Andresen V, 2020, LANCET GASTROENTEROL, V5, P658, DOI 10.1016/S2468-1253(20)30056-X
   [Anonymous], STUDY QUALITY ASSESS
   Aoki R, 2017, SCI REP-UK, V7, DOI 10.1038/srep43522
   Aron RAC, 2021, MICROORGANISMS, V9, DOI 10.3390/microorganisms9030618
   Arumugam M, 2011, NATURE, V473, P174, DOI 10.1038/nature09944
   Asemi Z, 2017, INT J PREVENTIVE MED, V8, DOI 10.4103/ijpvm.IJPVM_257_16
   Balfego M, 2016, LIPIDS HEALTH DIS, V15, DOI 10.1186/s12944-016-0245-0
   Beserra BTS, 2015, CLIN NUTR, V34, P845, DOI 10.1016/j.clnu.2014.10.004
   Bock PM, 2021, DIABETOLOGIA, V64, P26, DOI 10.1007/s00125-020-05295-1
   Brooks L, 2017, MOL METAB, V6, P48, DOI 10.1016/j.molmet.2016.10.011
   Brunkwall L, 2017, DIABETOLOGIA, V60, P943, DOI 10.1007/s00125-017-4278-3
   Chondronikola M, 2016, J INTERN MED, V280, P476, DOI 10.1111/joim.12527
   Cortez RV, 2018, SURG OBES RELAT DIS, V14, P1748, DOI 10.1016/j.soard.2018.07.021
   Dao MC, 2016, GUT, V65, P426, DOI 10.1136/gutjnl-2014-308778
   Davies NK, 2019, SURG OBES RELAT DIS, V15, P656, DOI 10.1016/j.soard.2019.01.033
   Dehghan P, 2014, NUTRITION, V30, P418, DOI 10.1016/j.nut.2013.09.005
   Derrien M, 2017, MICROB PATHOGENESIS, V106, P171, DOI 10.1016/j.micpath.2016.02.005
   Dong JP, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0168785
   Elbere I, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0241338
   Firouzi S, 2017, EUR J NUTR, V56, P1535, DOI 10.1007/s00394-016-1199-8
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Gotelli N.J., 2013, ENCY BIODIVERSITY 2, VVolume 5, P195, DOI 10.1016/B978-0-12-384719-5.00424-X
   Graessler J, 2013, PHARMACOGENOMICS J, V13, P514, DOI 10.1038/tpj.2012.43
   Gu YY, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-01682-2
   Guo Y, 2018, EUR J ENDOCRINOL, V178, P43, DOI [10.1530/EJE-17-0403, 10.1530/eje-17-0403]
   Gurung M, 2020, EBIOMEDICINE, V51, DOI 10.1016/j.ebiom.2019.11.051
   Houghton D, 2018, DIABETOLOGIA, V61, P1700, DOI 10.1007/s00125-018-4632-0
   Hsieh MC, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-35014-1
   Iskandar CF, 2019, TRENDS FOOD SCI TECH, V88, P121, DOI 10.1016/j.tifs.2019.03.020
   Johnson EL, 2017, J MOL MED, V95, P1, DOI 10.1007/s00109-016-1492-2
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Khalili Leila, 2019, Iranian Biomedical Journal, V23, P68, DOI [10.29252/.23.1.68, 10.29252/ibj.23.1.68]
   Koliaki C, 2017, BMC ENDOCR DISORD, V17, DOI 10.1186/s12902-017-0202-6
   Kong LC, 2013, AM J CLIN NUTR, V98, P16, DOI 10.3945/ajcn.113.058743
   Koren O, 2013, PLOS COMPUT BIOL, V9, DOI 10.1371/journal.pcbi.1002863
   Lambeth Stacey M, 2015, J Diabetes Obes, V2, P1
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Le Chatelier E, 2013, NATURE, V500, P541, DOI 10.1038/nature12506
   Le KA, 2013, FRONT PHYSIOL, V3, DOI 10.3389/fphys.2012.00496
   Lee CJ, 2019, OBES SURG, V29, P3239, DOI 10.1007/s11695-019-03976-4
   Liu HJ, 2018, J DIABETES INVEST, V9, P13, DOI 10.1111/jdi.12687
   Louis P, 2017, ENVIRON MICROBIOL, V19, P29, DOI 10.1111/1462-2920.13589
   Ma QT, 2019, BIOMED PHARMACOTHER, V117, DOI 10.1016/j.biopha.2019.109138
   Madsen MSA, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-52103-x
   Magouliotis DE, 2017, OBES SURG, V27, P1345, DOI 10.1007/s11695-017-2595-8
   Markowiak P, 2017, NUTRIENTS, V9, DOI 10.3390/nu9091021
   MARUHAMA Y, 1980, TOHOKU J EXP MED, V132, P453, DOI 10.1620/tjem.132.453
   Medina-Vera I, 2019, DIABETES METAB, V45, P122, DOI 10.1016/j.diabet.2018.09.004
   Mobini R, 2017, DIABETES OBES METAB, V19, P579, DOI 10.1111/dom.12861
   Moher D, 2010, INT J SURG, V8, P336, DOI [10.1136/bmj.b2535, 10.1016/j.ijsu.2010.02.007, 10.1016/j.ijsu.2010.07.299, 10.1186/s13643-015-0087-2]
   Montandon SA, 2017, GENES-BASEL, V8, DOI 10.3390/genes8100250
   Morel FB, 2015, J NUTR, V145, P2052, DOI 10.3945/jn.114.204909
   Murphy R, 2017, OBES SURG, V27, P917, DOI 10.1007/s11695-016-2399-2
   Nadal I, 2009, INT J OBESITY, V33, P758, DOI 10.1038/ijo.2008.260
   Ojo O, 2020, NUTRIENTS, V12, DOI 10.3390/nu12113239
   Pedersen C, 2016, BRIT J NUTR, V116, P1869, DOI 10.1017/S0007114516004086
   Preidis GA, 2020, GASTROENTEROLOGY, V159, P708, DOI 10.1053/j.gastro.2020.05.060
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Rao MY, 2019, J DIABETES RES, V2019, DOI 10.1155/2019/5101423
   Remely M, 2013, J DIABETES METAB, V4, DOI 10.4172/2155-6156.1000253
   Rinninella E, 2019, MICROORGANISMS, V7, DOI 10.3390/microorganisms7010014
   Roshanravan N, 2017, J CARDIOVASC THORAC, V9, P183, DOI 10.15171/jcvtr.2017.32
   Saeedi P, 2019, DIABETES RES CLIN PR, V157, DOI 10.1016/j.diabres.2019.107843
   Sato J, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-12535-9
   Sato J, 2014, DIABETES CARE, V37, P2343, DOI 10.2337/dc13-2817
   Schneeberger M, 2015, SCI REP-UK, V5, DOI 10.1038/srep16643
   Seiler CL, 2020, AM J GASTROENTEROL, V115, P1584, DOI 10.14309/ajg.0000000000000749
   Shin NR, 2020, AM J PHYSIOL-ENDOC M, V318, pE52, DOI 10.1152/ajpendo.00221.2019
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Sterne JAC, 2019, BMJ-BRIT MED J, V366, DOI 10.1136/bmj.l4898
   Su BL, 2015, J DIABETES, V7, P729, DOI 10.1111/1753-0407.12232
   Suez J, 2019, NAT MED, V25, P716, DOI 10.1038/s41591-019-0439-x
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Sun Y, 2013, ADV APPL MICROBIOL, V85, P93, DOI 10.1016/B978-0-12-407672-3.00003-4
   Tao YW, 2020, J TRANSL MED, V18, DOI 10.1186/s12967-020-02213-2
   Le TKC, 2015, BIOMED RES-TOKYO, V36, P63, DOI 10.2220/biomedres.36.63
   Tong XL, 2018, MBIO, V9, DOI 10.1128/mBio.02392-17
   Van den Abbeele P, 2010, APPL ENVIRON MICROB, V76, P5237, DOI 10.1128/AEM.00759-10
   Vesa CM, 2020, DIAGNOSTICS, V10, DOI 10.3390/diagnostics10050314
   Vulevic J, 2013, J NUTR, V143, P324, DOI 10.3945/jn.112.166132
   Wagner BD, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.01037
   Whang A, 2019, EBIOMEDICINE, V39, P591, DOI 10.1016/j.ebiom.2018.11.046
   Wiese M, 2019, BIOMED RES INT, V2019, DOI 10.1155/2019/4625279
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Yang JP, 2015, FRONT PHYSIOL, V6, DOI 10.3389/fphys.2015.00216
   Zeevi D, 2015, CELL, V163, P1079, DOI 10.1016/j.cell.2015.11.001
   Zhang XY, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0071108
   Zhang YF, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-18414-8
   Zhao L, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00233
   Zheng YJ, 2021, PHYTOMEDICINE, V88, DOI 10.1016/j.phymed.2020.153455
   Zmora N, 2018, CELL, V174, P1388, DOI 10.1016/j.cell.2018.08.041
NR 94
TC 4
Z9 4
U1 3
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1010-660X
EI 1648-9144
J9 MEDICINA-LITHUANIA
JI Med. Lith.
PD OCT
PY 2021
VL 57
IS 10
AR 1084
DI 10.3390/medicina57101084
PG 24
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA WT6QE
UT WOS:000715986600001
PM 34684121
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Li, ZT
   Zhu, L
   Hu, GA
   Sun, ZL
   Zhan, XB
   Gao, MJ
AF Li, Zhi-tao
   Zhu, Li
   Hu, Guo-ao
   Sun, Zheng-long
   Zhan, Xiao-bei
   Gao, Min-jie
TI Akkermansia muciniphila fermentation culture based on a novel bionic
   large intestine dynamic digestion model
SO FOOD BIOSCIENCE
LA English
DT Article
DE Akkermansia muciniphila; Short-chain fatty acids; Bioreactor;
   Fermentation
ID GUT MICROBIOTA; DIETARY POLYPHENOLS; MUCIN; INFLAMMATION; ASSOCIATION;
   METFORMIN; GLUCOSE; SPP.
AB Akkermansia muciniphila, a member of the human intestinal microflora, is a potential next-generation probiotic. Therefore, the optimization of in vitro culture conditions for A. muciniphila is a promising research direction. In this study, an in vitro fermentation culture of A. muciniphila was implemented using a novel bionic large intestine dynamic digestion model. Compared with static culture, the new bionic large intestine dynamic digestion model achieved 55.37% more biomass, accompanied by the significant growth of metabolites, such as acetic acid, propionic acid, and butyric acid. Moreover, the effects of fructo-oligosaccharide (FOS), blackberry concentrate powder, and metformin on the growth of A. muciniphila were compared. FOS, blackberry concentrate powder, and metformin did not significantly affect biomass growth, but FOS increased butyric acid generation by A. muciniphila by 32%. The outer membrane protein concentrations of A. muciniphila in FOS, polyphenols, and metformin are 30%-37% higher than that in the no added media. Electron microscopy indicated that the strains of the dynamic culture were superior to those of the static culture in terms of diameter and length. This study provides important progress in the industrial application of A. muciniphila as a probiotic.
C1 [Li, Zhi-tao; Hu, Guo-ao; Zhan, Xiao-bei; Gao, Min-jie] Jiangnan Univ, Sch Biotechnol, Key Lab Carbohydrate Chem & Biotechnol, Minist Educ, Wuxi 214122, Jiangsu, Peoples R China.
   [Zhu, Li] Wuxi Galaxy Biotech Co Ltd, Wuxi 214125, Jiangsu, Peoples R China.
   [Sun, Zheng-long] Chinese Acad Sci, Suzhou Inst Biomed Engn & Technol, Suzhou 215163, Peoples R China.
C3 Jiangnan University; Chinese Academy of Sciences; Suzhou Institute of
   Biomedical Engineering & Technology, CAS
RP Zhan, XB; Gao, MJ (通讯作者)，Jiangnan Univ, Sch Biotechnol, Key Lab Carbohydrate Chem & Biotechnol, Minist Educ, Wuxi 214122, Jiangsu, Peoples R China.
EM xbzhan@yahoo.com; gaominjie@msn.com
FU National Key Research and Development Program of China [2017YFD0400302];
   National First-Class Discipline Program of Light Industry Technology and
   Engineering [LITE2018-17]; Priority Academic Program Development of
   Jiangsu Higher Education Institutions, the 111 Project [111-2-06]
FX This work was supported in part by the National Key Research and
   Development Program of China (2017YFD0400302), the National FirstClass
   Discipline Program of Light Industry Technology and Engineering
   (LITE2018-17), and the Priority Academic Program Development of Jiangsu
   Higher Education Institutions, the 111 Project (No. 111-2-06) is
   gratefully acknowledged.
CR Anhe FF, 2016, GUT MICROBES, V7, P146, DOI 10.1080/19490976.2016.1142036
   Anhe FF, 2015, GUT, V64, P872, DOI 10.1136/gutjnl-2014-307142
   Barcena C, 2019, NAT MED, V25, P1234, DOI 10.1038/s41591-019-0504-5
   Belzer C, 2017, MBIO, V8, DOI [10.1128/mBio.00770-17, 10.1128/mbio.00770-17]
   Blacher E, 2019, NATURE, V572, P474, DOI 10.1038/s41586-019-1443-5
   Candela M, 2012, BMC MICROBIOL, V12, DOI 10.1186/1471-2180-12-95
   Chassaing B, 2015, NATURE, V519, P92, DOI 10.1038/nature14232
   Chia LW, 2018, ANTON LEEUW INT J G, V111, P859, DOI 10.1007/s10482-018-1040-x
   Collado MC, 2007, APPL ENVIRON MICROB, V73, P7767, DOI 10.1128/AEM.01477-07
   Dao MC, 2016, GUT, V65, P426, DOI 10.1136/gutjnl-2014-308778
   Depommier C, 2019, NAT MED, V25, P1096, DOI 10.1038/s41591-019-0495-2
   Derrien M, 2004, INT J SYST EVOL MICR, V54, P1469, DOI 10.1099/ijs.0.02873-0
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Everard A, 2011, DIABETES, V60, P2775, DOI 10.2337/db11-0227
   Guo X, 2016, J APPL MICROBIOL, V120, P452, DOI 10.1111/jam.13022
   Hagi T, 2020, APPL MICROBIOL BIOT, V104, P10641, DOI 10.1007/s00253-020-10976-3
   Ijssennagger N, 2015, P NATL ACAD SCI USA, V112, P10038, DOI 10.1073/pnas.1507645112
   Koecher KJ, 2014, J AGR FOOD CHEM, V62, P1332, DOI 10.1021/jf404688n
   Le Poul E, 2003, J BIOL CHEM, V278, P25481, DOI 10.1074/jbc.M301403200
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Li J, 2017, MICROBIOME, V5, DOI 10.1186/s40168-016-0222-x
   Li ZT, 2020, BIOCHEM ENG J, V154, DOI 10.1016/j.bej.2019.107431
   Li ZT, 2021, BMC MICROBIOL, V21, DOI 10.1186/s12866-021-02111-7
   Liebisch G, 2019, BIOMOLECULES, V9, DOI 10.3390/biom9040121
   Mitchell RJ, 2009, BIORESOURCE TECHNOL, V100, P5352, DOI 10.1016/j.biortech.2009.05.046
   Olson CA, 2018, CELL, V174, P497, DOI 10.1016/j.cell.2018.06.051
   Plovier H, 2017, NAT MED, V23, P107, DOI 10.1038/nm.4236
   Png CW, 2010, AM J GASTROENTEROL, V105, P2420, DOI 10.1038/ajg.2010.281
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Ramasamy US, 2014, J AGR FOOD CHEM, V62, P6794, DOI 10.1021/jf501254z
   Reid DT, 2016, EUR J NUTR, V55, P2399, DOI 10.1007/s00394-015-1047-2
   Roopchand DE, 2015, DIABETES, V64, P2847, DOI 10.2337/db14-1916
   Routy B, 2018, SCIENCE, V359, P91, DOI 10.1126/science.aan3706
   Sanna S, 2019, NAT GENET, V51, P600, DOI 10.1038/s41588-019-0350-x
   Van den Abbeele P, 2018, J FUNCT FOODS, V47, P163, DOI 10.1016/j.jff.2018.05.053
   van der Ark KCH, 2018, MICROB BIOTECHNOL, V11, P476, DOI 10.1111/1751-7915.13033
   Wang L, 2011, APPL ENVIRON MICROB, V77, P6718, DOI 10.1128/AEM.05212-11
   Zhai R, 2019, FRONT CELL INFECT MI, V9, DOI 10.3389/fcimb.2019.00239
   Zhan X., 2019, Visual bionic digestive system for human gastrointestinal tract model, Patent No. [US20190228681A1, 20190228681]
   Zhan X., 2020, Bionic digestive tract as well as preparation method and application thereof, Patent No. [US20200279509A1, 20200279509]
   Zhao SQ, 2017, J MOL ENDOCRINOL, V58, P1, DOI 10.1530/JME-16-0054
   Zhou KQ, 2017, J FUNCT FOODS, V33, P194, DOI 10.1016/j.jff.2017.03.045
   Zhou ZY, 2016, ACTA PHARMACOL SIN, V37, P1063, DOI 10.1038/aps.2016.21
NR 43
TC 1
Z9 1
U1 6
U2 40
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2212-4292
EI 2212-4306
J9 FOOD BIOSCI
JI Food Biosci.
PD OCT
PY 2021
VL 43
AR 101260
DI 10.1016/j.fbio.2021.101260
EA AUG 2021
PG 7
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA UZ0HV
UT WOS:000701894900011
DA 2023-06-08
ER

PT J
AU van Bommel, EJM
   Herrema, H
   Davids, M
   Kramer, MHH
   Nieuwdorp, M
   van Raalte, DH
AF van Bommel, E. J. M.
   Herrema, H.
   Davids, M.
   Kramer, M. H. H.
   Nieuwdorp, M.
   van Raalte, D. H.
TI Effects of 12-week treatment with dapagliflozin and gliclazide on faecal
   microbiome: Results of a double-blind randomized trial in patients with
   type 2 diabetes
SO DIABETES & METABOLISM
LA English
DT Article
DE Dapagliflozin; Gliclazide; Metabolic effects; Microbiome; Type 2
   diabetes
ID INTESTINAL MICROBIOTA; INSULIN SENSITIVITY; INDIVIDUALS
AB Aims/hypothesis. - Patients with type 2 diabetes (T2D) are usually treated with (combinations of) glucose-lowering medication. The effects of these drugs can be influenced by intestinal microbiota and vice versa, as these drugs can also influence microbiome composition. However, as there is currently little clinical insight into this bug-drug interaction, our study aimed to evaluate the effects of 12-week treatment with the SGLT2 inhibitor dapagliflozin and sulphonylurea gliclazide on gut microbiome composition in T2D patients treated with metformin.
   Methods. - A total of 44 patients were randomized to either dapagliflozin or gliclazide treatment for 12 weeks. At baseline and after 12 weeks, faecal samples and 24-h urine were collected. During study visits, anthropometric data were measured and blood samples drawn after an overnight fast. Microbiome composition was determined by 16S rRNA gene sequencing. Plasma glucose, insulin, HbA(1c) and urinary glucose excretion were measured using conventional methods.
   Results. - While dapagliflozin and gliclazide similarly improved glycaemic control, dapagliflozin reduced and gliclazide increased fasting insulin. Dapagliflozin also greatly increased urinary glucose excretion whereas gliclazide did not, while body mass index, fat mass percentage and waist circumference were reduced by dapagliflozin, but increased by gliclazide. However, neither treatment significantly affected either gut microbiome alpha diversity or composition and, after treatment, no associations were found between microbiome composition and other clinical parameters.
   Conclusion. - Even though gliclazide and dapagliflozin have different metabolic actions in patients with T2D, neither treatment altered the faecal microbiome, thereby suggesting that the observed metabolic changes are not mediated by their effects on the microbiota. (C) 2019 Published by Elsevier Masson SAS.
C1 [van Bommel, E. J. M.; Kramer, M. H. H.; van Raalte, D. H.] Univ Amsterdam, Diabet Ctr, Dept Internal Med, Med Ctr,VUmc, Amsterdam, Netherlands.
   [Herrema, H.; Davids, M.; Nieuwdorp, M.; van Raalte, D. H.] Univ Amsterdam, Dept Internal & Vasc Med, Med Ctr, AMC, Amsterdam, Netherlands.
C3 University of Amsterdam; Vrije Universiteit Amsterdam; University of
   Amsterdam; Academic Medical Center Amsterdam
RP van Bommel, EJM (通讯作者)，Univ Amsterdam, Med Ctr, Locat VUmc, De Boelelaan 1117, NL-1081 HV Amsterdam, Netherlands.
EM e.vanbommel@amsterdamumc.nl
RI Kramer, Mark/GWQ-3502-2022
OI Davids, Mark/0000-0003-3081-9124; Herrema, Hilde/0000-0002-0112-6348;
   van Raalte, Daniel/0000-0003-2894-6124
FU AstraZeneca
FX This trial was funded by AstraZeneca as an investigator-initiated study.
   The funder had no role in the study design, data analyses or
   interpretation, or drafting of the manuscript, nor in the decision to
   submit the manuscript for publication.
CR Depommier C, 2019, NAT MED, V25, P1096, DOI 10.1038/s41591-019-0495-2
   Ferrannini G, 2015, DIABETES CARE, V38, P1730, DOI 10.2337/dc15-0355
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Gu YY, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-01682-2
   Khan MT, 2014, CELL METAB, V20, P753, DOI 10.1016/j.cmet.2014.07.006
   Koh A, 2018, CELL, V175, P947, DOI 10.1016/j.cell.2018.09.055
   Kootte RS, 2017, CELL METAB, V26, P611, DOI 10.1016/j.cmet.2017.09.008
   Lee DM, 2018, CARDIOVASC DIABETOL, V17, DOI 10.1186/s12933-018-0708-x
   Li Z, 2018, GUT, V67, P1269, DOI 10.1136/gutjnl-2017-314050
   Love MI, 2014, GENOME BIOL, V15, DOI 10.1186/s13059-014-0550-8
   McMurdie PJ, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0061217
   Rohart F, 2017, PLOS COMPUT BIOL, V13, DOI 10.1371/journal.pcbi.1005752
   Shen Y, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-01619-1
   van bommel EJM MM, 2019, KIDNEY INT
   van Bommel EJM, 2017, CLIN J AM SOC NEPHRO, V12, P700, DOI 10.2215/CJN.06080616
   Vrieze A, 2012, GASTROENTEROLOGY, V143, P913, DOI 10.1053/j.gastro.2012.06.031
   Whang A, 2019, EBIOMEDICINE, V39, P591, DOI 10.1016/j.ebiom.2018.11.046
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
NR 18
TC 31
Z9 31
U1 1
U2 9
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 1262-3636
EI 1878-1780
J9 DIABETES METAB
JI Diabetes Metab.
PD APR
PY 2020
VL 46
IS 2
BP 164
EP 168
DI 10.1016/j.diabet.2019.11.005
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA LG7IQ
UT WOS:000528270300012
PM 31816432
DA 2023-06-08
ER

PT J
AU Yan, J
   Li, JJ
   Xue, QY
   Xie, SQ
   Jiang, JJ
   Li, P
   Du, B
AF Yan, Jing
   Li, Junjian
   Xue, Qiuyan
   Xie, Shiqing
   Jiang, Jinjin
   Li, Pan
   Du, Bing
TI Bacillus sp. DU-106 ameliorates type 2 diabetes by modulating gut
   microbiota in high-fat-fed and streptozotocin-induced mice
SO JOURNAL OF APPLIED MICROBIOLOGY
LA English
DT Article
DE Bacillus sp; DU-106; gut microbiota; hyperglycaemic; metformin;
   probiotics; type 2 diabetes
ID LACTOBACILLUS-CASEI CCFM419; MULTI-STRAIN PROBIOTICS; LACTIC-ACID
   BACTERIA; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   FAECALIBACTERIUM-PRAUSNITZII; GLYCEMIC CONTROL; HYPERGLYCEMIA;
   POLYSACCHARIDES; MODEL
AB Aims Type 2 diabetes (T2D) is a chronic disease that manifests as endocrine and metabolic disorders that seriously threatening public health. This study aimed to investigate the effects of Bacillus sp. DU-106 on anti-diabetic effects and gut microbiota in C57BL/6J mice fed a high-fat diet and streptozotocin-induced T2D. Methods and Results Bacillus sp. DU-106 was administered to model mice for eight consecutive weeks. Oral administration of Bacillus sp. DU-106 decreased food and water intake and alleviated body weight loss. Moreover, Bacillus sp. DU-106 imparted several health benefits to mice, including balanced blood glucose, alleviation of insulin resistance in T2D mice and an improvement in lipid metabolism. Furthermore, Bacillus sp. DU-106 protected against liver and pancreatic impairment. Additionally, Bacillus sp. DU-106 treatment reshaped intestinal flora by enhancing gut microbial diversity and enriching the abundance of certain functional bacteria. Conclusion Collectively, these findings suggest that Bacillus sp. DU-106 can ameliorate T2D by regulating the gut microbiota. Significance and Impact of Study Therefore, a novel probiotic, Bacillus sp. DU-106 may be a promising therapeutic agent for improving and alleviating T2D in mice.
C1 [Yan, Jing; Li, Junjian; Xue, Qiuyan; Xie, Shiqing; Li, Pan; Du, Bing] South China Agr Univ, Coll Food Sci, Wushan Rd 483, Guangzhou 510642, Guangdong, Peoples R China.
   [Jiang, Jinjin] Guangzhou City Polytech, Guangzhou, Guangdong, Peoples R China.
C3 South China Agricultural University
RP Du, B (通讯作者)，South China Agr Univ, Coll Food Sci, Wushan Rd 483, Guangzhou 510642, Guangdong, Peoples R China.
EM dubing@scau.edu.cn
FU China Agriculture Research System of MOF and MARA [CARS-21]; Key-Area
   Research and Development Program of Guangdong Province [2020B020226008];
   Natural Science Foundation of Guangdong Province [2020A1515011268];
   Guangzhou Science and technology planning project [202102080487]
FX The authors thank the China Agriculture Research System of MOF and MARA
   (grant number: CARS-21), Key-Area Research and Development Program of
   Guangdong Province (grant number: 2020B020226008), Natural Science
   Foundation of Guangdong Province (grant number: 2020A1515011268) and
   Guangzhou Science and technology planning project (grant number:
   202102080487) for financial support.
CR Abdellatif AM, 2019, J DIABETES, V11, P632, DOI 10.1111/1753-0407.12915
   Cao Y, 2018, J AGR FOOD CHEM, V66, P2988, DOI 10.1021/acs.jafc.8b00404
   Chen C, 2018, FOOD FUNCT, V9, P3732, DOI [10.1039/C7FO01346A, 10.1039/c7fo01346a]
   Chen P, 2014, J FUNCT FOODS, V10, P318, DOI 10.1016/j.jff.2014.06.014
   De Vadder F, 2014, CELL, V156, P84, DOI 10.1016/j.cell.2013.12.016
   den Hartigh LJ, 2018, J NUTR, V148, P562, DOI 10.1093/jn/nxy011
   Dong J, 2020, INT J BIOL MACROMOL, V159, P725, DOI 10.1016/j.ijbiomac.2020.05.042
   Ejtahed HS, 2012, NUTRITION, V28, P539, DOI 10.1016/j.nut.2011.08.013
   Elshaghabee FMF, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.01490
   Ferreira-Halder CV, 2017, BEST PRACT RES CL GA, V31, P643, DOI 10.1016/j.bpg.2017.09.011
   Firouzi S, 2017, EUR J NUTR, V56, P1535, DOI 10.1007/s00394-016-1199-8
   Fu X., 2018, CRIT REV FOOD SCI, V59, P130
   Gurung M, 2020, EBIOMEDICINE, V51, DOI 10.1016/j.ebiom.2019.11.051
   Huang DR, 2022, PROBIOTICS ANTIMICRO, V14, P372, DOI 10.1007/s12602-022-09906-8
   Huang JZ, 2021, APPL MICROBIOL BIOT, V105, P287, DOI 10.1007/s00253-020-10977-2
   Jackson MA, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-018-05184-7
   Jonas JC, 1999, J BIOL CHEM, V274, P14112, DOI 10.1074/jbc.274.20.14112
   Kesika P, 2019, BIOMED RES INT, V2019, DOI 10.1155/2019/1531567
   LAAKSO M, 1993, AM J EPIDEMIOL, V137, P959, DOI 10.1093/oxfordjournals.aje.a116768
   Lai YJ, 2020, J FUNCT FOODS, V75, DOI 10.1016/j.jff.2020.104247
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Le Chatelier E, 2013, NATURE, V500, P541, DOI 10.1038/nature12506
   Lee YS, 2021, FOOD FUNCT, V12, P6363, DOI [10.1039/d1fo00698c, 10.1039/D1FO00698C]
   Li C, 2014, J AGR FOOD CHEM, V62, P11884, DOI 10.1021/jf503681r
   Li P, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.02216
   Li X, 2017, BENEF MICROBES, V8, P421, DOI 10.3920/BM2016.0167
   Li X, 2016, J APPL MICROBIOL, V121, P1727, DOI 10.1111/jam.13276
   Li XF, 2016, FOOD FUNCT, V7, P4851, DOI 10.1039/c6fo01147k
   Liu RX, 2017, NAT MED, V23, P859, DOI 10.1038/nm.4358
   Liu YJ, 2015, J TRACE ELEM MED BIO, V32, P155, DOI 10.1016/j.jtemb.2015.07.007
   Liu YL, 2021, FOOD FUNCT, V12, P1829, DOI [10.1039/d0fo02533j, 10.1039/D0FO02533J]
   Long SL, 2017, MOL ASPECTS MED, V56, P54, DOI 10.1016/j.mam.2017.06.002
   Ma QT, 2019, BIOMED PHARMACOTHER, V117, DOI 10.1016/j.biopha.2019.109138
   Martinez-Guryn K, 2018, CELL HOST MICROBE, V23, P458, DOI 10.1016/j.chom.2018.03.011
   McBean AM, 2004, DIABETES CARE, V27, P2317, DOI 10.2337/diacare.27.10.2317
   Miquel S, 2013, CURR OPIN MICROBIOL, V16, P255, DOI 10.1016/j.mib.2013.06.003
   Nie QX, 2019, FOOD HYDROCOLLOID, V86, P34, DOI 10.1016/j.foodhyd.2017.12.026
   O'Connor S, 2017, MATURITAS, V104, P11, DOI 10.1016/j.maturitas.2017.07.005
   Ohtsu A, 2019, ORAL DIS, V25, P868, DOI 10.1111/odi.13044
   Oren R., 2016, ARCH TOXICOL, V91, P1
   Panwar H, 2013, DIABETES-METAB RES, V29, P103, DOI 10.1002/dmrr.2376
   Phung OJ, 2012, ANN PHARMACOTHER, V46, P469, DOI 10.1345/aph.1Q554
   Qu Ling, 2018, J Agric Food Chem, V66, P12696, DOI 10.1021/acs.jafc.8b04874
   Razmpoosh E, 2019, DIABETES METAB SYND, V13, P175, DOI 10.1016/j.dsx.2018.08.008
   Remely M, 2016, ENDOCR METAB IMMUNE, V16, P99, DOI 10.2174/1871530316666160831093813
   Sabatino A, 2017, CURR DIABETES REP, V17, DOI 10.1007/s11892-017-0841-z
   Sanders M E, 2003, Compr Rev Food Sci Food Saf, V2, P101, DOI 10.1111/j.1541-4337.2003.tb00017.x
   Sircana A, 2018, CURR DIABETES REP, V18, DOI 10.1007/s11892-018-1057-6
   Wang C, 2019, EXP THER MED, V17, P3555, DOI 10.3892/etm.2019.7383
   Wang G, 2020, FOOD FUNCT, V11, P5898, DOI [10.1039/c9fo02761k, 10.1039/C9FO02761K]
   Wang G, 2017, FOOD FUNCT, V8, P3155, DOI 10.1039/c7fo00593h
   Wang T, 2022, EUR J NUTR, V61, P85, DOI 10.1007/s00394-021-02627-8
   Wang XW, 2022, FOOD RES INT, V155, DOI 10.1016/j.foodres.2022.110998
   Wang YM, 2020, BIOMED PHARMACOTHER, V125, DOI 10.1016/j.biopha.2020.109914
   Whiting DR, 2011, DIABETES RES CLIN PR, V94, P311, DOI 10.1016/j.diabres.2011.10.029
   Wu JJ, 2016, CARBOHYD POLYM, V144, P474, DOI 10.1016/j.carbpol.2016.02.040
   Wu QF, 2021, FOOD FUNCT, V12, P3572, DOI [10.1039/D0FO03329D, 10.1039/d0fo03329d]
   Yu J, 2009, FOOD CHEM, V117, P42, DOI 10.1016/j.foodchem.2009.03.073
   Yuan T, 2019, REDOX BIOL, V20, P247, DOI 10.1016/j.redox.2018.09.025
   Zeng Z, 2021, FOOD FUNCT, V12, P6809, DOI [10.1039/D1FO00515D, 10.1039/d1fo00515d]
   Zhang CC, 2019, FOOD FUNCT, V10, P3252, DOI [10.1039/C9FO00119K, 10.1039/c9fo00119k]
   Zhang SW, 2011, AFR J MICROBIOL RES, V5, P5194, DOI 10.5897/AJMR11.997
   Zhang X, 2015, SCI REP-UK, V5, DOI 10.1038/srep14405
   Zhang YF, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-18414-8
   Zhao D, 2020, FOOD FUNCT, V11, P6528, DOI [10.1039/d0fo00180e, 10.1039/D0FO00180E]
NR 65
TC 2
Z9 2
U1 6
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1364-5072
EI 1365-2672
J9 J APPL MICROBIOL
JI J. Appl. Microbiol.
PD NOV
PY 2022
VL 133
IS 5
BP 3126
EP 3138
DI 10.1111/jam.15773
EA AUG 2022
PG 13
WC Biotechnology & Applied Microbiology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Microbiology
GA 5K7HB
UT WOS:000842076800001
PM 35951725
OA Bronze
DA 2023-06-08
ER

PT J
AU Xiang, L
   Wu, QB
   Osada, H
   Yoshida, M
   Pan, WS
   Qi, JH
AF Xiang, Lan
   Wu, Qiaobei
   Osada, Hiroyuki
   Yoshida, Minoru
   Pan, Wensheng
   Qi, Jianhua
TI Peanut skin extract ameliorates the symptoms of type 2 diabetes mellitus
   in mice by alleviating inflammation and maintaining gut microbiota
   homeostasis
SO AGING-US
LA English
DT Article
DE peanut skin extract (PSE); gut microbiota; type 2 diabetes;
   anti-inflammation; mice
ID INSULIN-RESISTANCE; POLYPHENOLS; PROTEINS; OBESITY
AB In this study, mice with type 2 diabetes mellitus (T2DM) induced by high-fat diet were used to investigate the antidiabetic effect and mechanism of action of peanut skin extract (PSE). Results revealed that the fasting blood glucose, body weight, and food intake of mice with T2DM significantly decreased after they were given PSE. The effects of 80 mg/kg PSE were similar to those of 140 mg/kg metformin (MET). The glucose tolerance and insulin sensitivity of the mice also improved. The composition of intestinal microflora in the mice significantly changed after PSE administration. In particular, no Actinobacteria was detected in the PSE-treated group, and the ratio of Firmicutes to Bacteroidetes was remarkably reduced. PSE also increased the abundance of gut microbiota involved in fatty acid biosynthesis, lipid biosynthesis, and sucrose metabolism. The abundance of gut microbiota related to aminoacyl-tRNA biosynthesis also decreased. Lipopolysaccharide, interleukin (IL)-6, IL-1 beta and tumor necrosis factor-alpha in the blood, liver and adipose tissue were reduced by PSE. Similarly, the mRNA expression levels of IkappaB kinase and nuclear factor kappaB in the hypothalamus were reduced by PSE. These results suggested that PSE and MET elicited significant antidiabetic effects by maintaining gut microbiota and inhibiting inflammation.
C1 [Xiang, Lan; Wu, Qiaobei; Qi, Jianhua] Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou, Peoples R China.
   [Osada, Hiroyuki] RIKEN, Ctr Sustainable Resource Sci, Chem Biol Res Grp, Wako, Saitama, Japan.
   [Yoshida, Minoru] RIKEN, Ctr Sustainable Resource Sci, Chem Genom Res Grp, Wako, Saitama, Japan.
   [Yoshida, Minoru] Univ Tokyo, Dept Biotechnol, Bunkyo Ku, Tokyo, Japan.
   [Yoshida, Minoru] Univ Tokyo, Collaborat Res Inst Innovat Microbiol, Bunkyo Ku, Tokyo, Japan.
   [Pan, Wensheng] Zhejiang Prov Peoples Hosp, Peoples Hosp, Hangzhou Med Coll, Dept Gastroenterol, Hangzhou, Zhejiang, Peoples R China.
C3 Zhejiang University; RIKEN; RIKEN; University of Tokyo; University of
   Tokyo; Hangzhou Medical College; Zhejiang Provincial People's Hospital
RP Xiang, L; Qi, JH (通讯作者)，Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou, Peoples R China.
EM lxiang@zju.edu.cn; qijianhua@zju.edu.cn
RI Yoshida, Minoru/C-8049-2014; Osada, Hiroyuki/AAY-6254-2020
OI Yoshida, Minoru/0000-0002-4376-5674; 
FU National Key R&D Program of China [2019YFE0100700, 2017YFE0117200];
   National Natural Science Foundation of China [21661140001, 21877098,
   21572204]
FX This work was financially supported by the National Key R&D Program of
   China (Grant No. 2019YFE0100700, Grant No. 2017YFE0117200), the National
   Natural Science Foundation of China (Grant No. 21661140001, 21877098,
   and 21572204)
CR Bansode RR, 2012, FOOD CHEM, V135, P1659, DOI 10.1016/j.foodchem.2012.06.034
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   Caricilli AM, 2013, NUTRIENTS, V5, P829, DOI 10.3390/nu5030829
   Carmody RN, 2015, CELL HOST MICROBE, V17, P72, DOI 10.1016/j.chom.2014.11.010
   Chang CJ, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms8489
   Fathy SA, 2019, BIOMARKERS, V24, P43, DOI 10.1080/1354750X.2018.1501761
   Francisco MLD, 2009, FOOD CHEM, V117, P356, DOI 10.1016/j.foodchem.2009.03.110
   Goszcz K, 2017, BRIT J PHARMACOL, V174, P1209, DOI 10.1111/bph.13708
   Han LH, 2019, NUTRIENTS, V11, DOI 10.3390/nu11030670
   Kastl AJ, 2020, CELL MOL GASTROENTER, V9, P33, DOI 10.1016/j.jcmgh.2019.07.006
   Khan N, 2014, NUTRIENTS, V6, P844, DOI 10.3390/nu6020844
   Li B, 2020, MOL NUTR FOOD RES, V64, DOI 10.1002/mnfr.201901315
   Li K, 2019, FOOD FUNCT, V10, P1915, DOI 10.1039/c8fo02265h
   Li XW, 2018, MOLECULES, V23, DOI 10.3390/molecules23123245
   Liu CX, 2016, CYTOKINE, V86, P100, DOI 10.1016/j.cyto.2016.06.028
   Odegaard JI, 2013, SCIENCE, V339, P172, DOI 10.1126/science.1230721
   Pandey KB, 2009, OXID MED CELL LONGEV, V2, P270, DOI 10.4161/oxim.2.5.9498
   Resmini E, 2009, ACTA DIABETOL, V46, P85, DOI 10.1007/s00592-009-0112-9
   Sampson TR, 2016, CELL, V167, P1469, DOI 10.1016/j.cell.2016.11.018
   Sanders TH, 2000, J AGR FOOD CHEM, V48, P1243, DOI 10.1021/jf990737b
   Seedevi P, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-57486-w
   Senn JJ, 2002, DIABETES, V51, P3391, DOI 10.2337/diabetes.51.12.3391
   Shi H, 2006, J CLIN INVEST, V116, P3015, DOI 10.1172/JCI28898
   Sigal M, 2017, NATURE, V548, P451, DOI 10.1038/nature23642
   Tilg H, 2008, TRENDS ENDOCRIN MET, V19, P371, DOI 10.1016/j.tem.2008.08.005
   Torisu T, 2007, GENES CELLS, V12, P143, DOI 10.1111/j.1365-2443.2007.01044.x
   Ueki K, 2004, MOL CELL BIOL, V24, P5434, DOI 10.1128/MCB.24.12.5434-5446.2004
   Ueki K, 2004, P NATL ACAD SCI USA, V101, P10422, DOI 10.1073/pnas.0402511101
   Wang PC, 2016, CARBOHYD POLYM, V148, P86, DOI 10.1016/j.carbpol.2016.02.060
   Xiang L, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/2935315
   Xiang L, 2016, NUTRIENTS, V8, DOI 10.3390/nu8050256
   Yang CS, 2009, NAT REV CANCER, V9, P429, DOI 10.1038/nrc2641
   Yang YC, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0067755
   Zeng YH, 2020, J AGR FOOD CHEM, V68, P4374, DOI 10.1021/acs.jafc.0c00118
   Zhang G, 2013, NATURE, V497, P211, DOI 10.1038/nature12143
NR 36
TC 16
Z9 16
U1 5
U2 71
PU IMPACT JOURNALS LLC
PI ORCHARD PARK
PA 6666 E QUAKER ST, STE 1, ORCHARD PARK, NY 14127 USA
SN 1945-4589
J9 AGING-US
JI Aging-US
PD JUL 31
PY 2020
VL 12
IS 14
BP 13991
EP 14018
PG 28
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Geriatrics & Gerontology
GA MY8LU
UT WOS:000558669300012
PM 32699185
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Martinez-Lopez, YE
   Esquivel-Hernandez, DA
   Sanchez-Castaneda, JP
   Neri-Rosario, D
   Guardado-Mendoza, R
   Resendis-Antonio, O
AF Estrella Martinez-Lopez, Yoscelina
   Esquivel-Hernandez, Diego A.
   Paul Sanchez-Castaneda, Jean
   Neri-Rosario, Daniel
   Guardado-Mendoza, Rodolfo
   Resendis-Antonio, Osbaldo
TI Type 2 diabetes, gut microbiome, and systems biology: A novel
   perspective for a new era
SO GUT MICROBES
LA English
DT Review
DE Gut microbiome; type 2 diabetes; diet; physical activity; anti-diabetic
   drugs; high-throughput data; personalized medicine; systems biology;
   dysbiosis
ID PERSONALIZED NUTRITION; INTESTINAL MICROBIOTA; METABOLIC DISEASES;
   BARIATRIC SURGERY; OBESITY; METFORMIN; INDIVIDUALS; MODULATION; FIBER;
   METAGENOME
AB The association between the physio-pathological variables of type 2 diabetes (T2D) and gut microbiota composition suggests a new avenue to track the disease and improve the outcomes of pharmacological and non-pharmacological treatments. This enterprise requires new strategies to elucidate the metabolic disturbances occurring in the gut microbiome as the disease progresses. To this end, physiological knowledge and systems biology pave the way for characterizing microbiota and identifying strategies in a move toward healthy compositions. Here, we dissect the recent associations between gut microbiota and T2D. In addition, we discuss recent advances in how drugs, diet, and exercise modulate the microbiome to favor healthy stages. Finally, we present computational approaches for disentangling the metabolic activity underlying host-microbiota codependence. Altogether, we envision that the combination of physiology and computational modeling of microbiota metabolism will drive us to optimize the diagnosis and treatment of T2D patients in a personalized way.
C1 [Estrella Martinez-Lopez, Yoscelina; Esquivel-Hernandez, Diego A.; Paul Sanchez-Castaneda, Jean; Neri-Rosario, Daniel; Resendis-Antonio, Osbaldo] Inst Nacl Med Genom INMEGEN, Human Syst Biol Lab, Mexico City, DF, Mexico.
   [Estrella Martinez-Lopez, Yoscelina] Univ Nacl Autonoma Mexico, Programa Doctorado Ciencias Med Odontol & Salud, Ciudad De Mexico, Mexico.
   [Estrella Martinez-Lopez, Yoscelina; Guardado-Mendoza, Rodolfo] Univ Guanajuato, Metab Res Lab, Dept Med & Nutr, Guanajuato, Mexico.
   [Paul Sanchez-Castaneda, Jean; Neri-Rosario, Daniel] Univ Nacl Autonoma Mexico, Programa Maestria Ciencias Bioquim, Ciudad De Mexico, Mexico.
   [Guardado-Mendoza, Rodolfo] Hosp Reg Alta Especialidad Bajio Leon, Res Dept, Guanajuato, Mexico.
   [Resendis-Antonio, Osbaldo] Univ Nacl Autonoma Mexico, Coordinac Invest Cient Red Apoyo Invest, Ciudad De Mexico, Mexico.
C3 Instituto Nacional de Medicina Genomica; Universidad Nacional Autonoma
   de Mexico; Universidad de Guanajuato; Universidad Nacional Autonoma de
   Mexico; Universidad Nacional Autonoma de Mexico
RP Guardado-Mendoza, R (通讯作者)，Univ Guanajuato, Metab Res Lab, Dept Med & Nutr, Guanajuato, Mexico.; Resendis-Antonio, O (通讯作者)，Univ Nacl Autonoma Mexico, Ctr Ciencias Complejidad, Perifer Sur 4809, Ciudad De Mexico 14610, Cdmx, Mexico.
EM guardamen@gmail.com; oresendis@inmegen.gob.mx
RI Esquivel-Hernández, Diego A./AAD-9456-2020
OI Esquivel-Hernández, Diego A./0000-0002-3636-4514; RESENDIS,
   OSBALDO/0000-0001-5220-541X; Neri Rosario, Daniel/0000-0002-3899-5133;
   Martinez Lopez, Yoscelina Estrella/0000-0002-9481-3381
FU CONACYT [425859/2020]; PAPIIT-UNAM [IA202720]; National Institute of
   Genomic Medicine (INMEGEN, Mexico)
FX The authors thank the financial support from CONACYT (Grant Ciencia de
   Frontera 2019, FORDECYT-PRONACES/425859/2020), PAPIIT-UNAM (IA202720),
   and an internal grant from the National Institute of Genomic Medicine
   (INMEGEN, Mexico).
CR Akerman NH, 2013, FRONT MICROBIOL, V4, DOI 10.3389/fmicb.2013.00185
   Akpinar O., 2018, J CELL NEUROSCI OXID, V10, P783, DOI [10.37212/jcnos.610103, DOI 10.37212/JCNOS.610103]
   Alcocer-Gomez E., 2018, INFLAMMASOMES CLIN T, DOI [10.1007/978-3-319-89390-7, DOI 10.1007/978-3-319-89390-7]
   Allaband C, 2019, CLIN GASTROENTEROL H, V17, P218, DOI 10.1016/j.cgh.2018.09.017
   Aria M, 2017, J INFORMETR, V11, P959, DOI 10.1016/j.joi.2017.08.007
   Bastida E, 2001, J Community Health Nurs, V18, P75, DOI 10.1207/153276501300118494
   Bauer E, 2017, PLOS COMPUT BIOL, V13, DOI 10.1371/journal.pcbi.1005544
   Belkaid Y, 2014, CELL, V157, P121, DOI 10.1016/j.cell.2014.03.011
   Bengtsson-Palme J, 2020, COMPUT STRUCT BIOTEC, V18, P3987, DOI 10.1016/j.csbj.2020.11.043
   Bharti R, 2021, BRIEF BIOINFORM, V22, P178, DOI 10.1093/bib/bbz155
   Bolyen E, 2019, NAT BIOTECHNOL, V37, P852, DOI 10.1038/s41587-019-0209-9
   Boni-Schnetzler M, 2008, J CLIN ENDOCR METAB, V93, P4065, DOI 10.1210/jc.2008-0396
   Bucci V, 2014, J MOL BIOL, V426, P3907, DOI 10.1016/j.jmb.2014.03.017
   Chakaroun RM, 2020, NUTRIENTS, V12, DOI 10.3390/nu12041082
   Charpentier J, 2021, ACTA DIABETOL, V58, P881, DOI 10.1007/s00592-020-01657-8
   Chaudhury A, 2017, FRONT ENDOCRINOL, V8, DOI 10.3389/fendo.2017.00006
   Chawla D, 2019, INTEGR FOOD NUTR MET, V6, P1, DOI [10.15761/IFNM.1000267, DOI 10.15761/IFNM.1000267]
   Clauss M, 2021, FRONT NUTR, V8, DOI 10.3389/fnut.2021.637010
   Das T, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-82538-0
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   De Vadder F, 2014, CELL, V156, P84, DOI 10.1016/j.cell.2013.12.016
   de Vos WM, 2013, NATURE, V498, P48, DOI 10.1038/nature12251
   Debedat J, 2022, GUT MICROBES, V14, DOI 10.1080/19490976.2022.2050635
   den Besten G, 2015, DIABETES, V64, P2398, DOI 10.2337/db14-1213
   Deng Y, 2012, BMC BIOINFORMATICS, V13, DOI 10.1186/1471-2105-13-113
   Dethlefsen L, 2011, P NATL ACAD SCI USA, V108, P4554, DOI 10.1073/pnas.1000087107
   Diaz-Rizzolo DA, 2020, CLIN NUTR, V39, P524, DOI 10.1016/j.clnu.2019.02.035
   Diener C, 2021, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.602326
   Diener C, 2020, MSYSTEMS, V5, DOI 10.1128/mSystems.00606-19
   Dillard LR, 2021, MOL OMICS, V17, P365, DOI 10.1039/d0mo00154f
   Duncan SH, 2002, INT J SYST EVOL MICR, V52, P1615, DOI 10.1099/00207713-52-5-1615
   Durganaudu H., 2020, PROG MICROBES MOL BI, V3, DOI [10.36877/pmmb.a0000082, DOI 10.36877/PMMB.A0000082]
   Dwiyanto J, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-82311-3
   Ebrahim A, 2013, BMC SYST BIOL, V7, DOI 10.1186/1752-0509-7-74
   Faust Karoline, 2016, F1000Res, V5, P1519
   Ferrucci L, 2018, NAT REV CARDIOL, V15, P505, DOI 10.1038/s41569-018-0064-2
   Forslund K, 2017, NATURE, V545, P116, DOI 10.1038/nature22318
   Francino MP, 2016, FRONT MICROBIOL, V6, DOI 10.3389/fmicb.2015.01543
   Fujisaka S, 2016, J CLIN INVEST, V126, P4430, DOI 10.1172/JCI86674
   Gaike AH, 2020, MSYSTEMS, V5, DOI 10.1128/mSystems.00578-19
   Galicia-Garcia U, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21176275
   Garcia-Mazcorro JF, 2018, J MICROBIOL BIOTECHN, V28, P1247, DOI 10.4014/jmb.1803.03020
   Ghosh A., 2021, ADV BIOINF, P333, DOI [10.1007/978-981-33-6191-1_17, DOI 10.1007/978-981-33-6191-1_17]
   Girdhar K, 2022, DIABETES, V71, P945, DOI 10.2337/db21-0382
   Gojda J, 2021, BIOMOLECULES, V11, DOI 10.3390/biom11101414
   Graessler J, 2013, PHARMACOGENOMICS J, V13, P514, DOI 10.1038/tpj.2012.43
   Greenacre M, 2021, ANNU REV STAT APPL, V8, P271, DOI 10.1146/annurev-statistics-042720-124436
   Guasch-Ferre M, 2016, DIABETES CARE, V39, P833, DOI 10.2337/dc15-2251
   Han JL, 2014, WORLD J GASTROENTERO, V20, P17737, DOI 10.3748/wjg.v20.i47.17737
   Hanssen NMJ, 2021, CELL METAB, V33, P1098, DOI 10.1016/j.cmet.2021.05.005
   Hasan N, 2019, PEERJ, V7, DOI 10.7717/peerj.7502
   Hills RD, 2019, NUTRIENTS, V11, DOI 10.3390/nu11071613
   Hino S, 2020, J NUTR, V150, P2656, DOI 10.1093/jn/nxaa097
   Holscher HD, 2020, J ACAD NUTR DIET, V120, P495, DOI 10.1016/j.jand.2019.12.016
   Huda MN, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.632335
   Iatcu CO, 2022, NUTRIENTS, V14, DOI 10.3390/nu14010166
   Ilhan ZE, 2020, NPJ BIOFILMS MICROME, V6, DOI 10.1038/s41522-020-0122-5
   Imai Y, 2013, DIABETES OBES METAB, V15, P117, DOI 10.1111/dom.12161
   Ismael S, 2021, NUTRIENTS, V13, DOI 10.3390/nu13041228
   Leon-Pedroza JI, 2015, CIR CIR, V83, P543, DOI 10.1016/j.circir.2015.05.041
   Jang HR, 2021, WORLD J DIABETES, V12, DOI 10.4239/wjd.v12.i6.730
   Jialal I, 2012, DIABETES CARE, V35, P900, DOI 10.2337/dc11-2375
   Jin ZL, 2021, WORLD J DIABETES, V12, P1187, DOI 10.4239/wjd.v12.i8.1187
   Karagiannis T, 2014, THER ADV DRUG SAF, V5, P138, DOI 10.1177/2042098614523031
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kassaian N, 2020, NUTRITION, V79-80, DOI 10.1016/j.nut.2020.110854
   Kawasaki T, 2014, FRONT IMMUNOL, V5, DOI 10.3389/fimmu.2014.00461
   Khandelwal RA, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0064567
   Knight R, 2018, NAT REV MICROBIOL, V16, P410, DOI 10.1038/s41579-018-0029-9
   Kumar M, 2019, NAT MICROBIOL, V4, P1253, DOI 10.1038/s41564-019-0491-9
   Kuntal BK, 2019, FRONT MICROBIOL, V10, DOI 10.3389/fmicb.2019.00288
   Lambert JE, 2015, APPL PHYSIOL NUTR ME, V40, P749, DOI 10.1139/apnm-2014-0452
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Lau E, 2021, DIABETOL METAB SYNDR, V13, DOI 10.1186/s13098-021-00672-1
   Lee H, 2018, GUT MICROBES, V9, P155, DOI 10.1080/19490976.2017.1405209
   Lee SG, 2019, CLIN CHEM LAB MED, V57, P1218, DOI 10.1515/cclm-2018-0741
   Leeming ER, 2019, NUTRIENTS, V11, DOI 10.3390/nu11122862
   Ley RE, 2010, CURR OPIN GASTROEN, V26, P5, DOI 10.1097/MOG.0b013e328333d751
   Lieven C, 2020, NAT BIOTECHNOL, V38, P272, DOI 10.1038/s41587-020-0446-y
   Lipworth W, 2019, ASIAN BIOETHICS REV, V11, P289, DOI 10.1007/s41649-019-00095-1
   Liu HJ, 2018, J DIABETES INVEST, V9, P13, DOI 10.1111/jdi.12687
   Liu XF, 2015, J AGR FOOD CHEM, V63, P7885, DOI 10.1021/acs.jafc.5b02404
   Liu Y, 2020, CELL METAB, V31, P77, DOI 10.1016/j.cmet.2019.11.001
   Lusiak-Szelachowska M, 2020, MICROORGANISMS, V8, DOI 10.3390/microorganisms8122012
   Ma YF, 2018, MICROBIOME, V6, DOI 10.1186/s40168-018-0410-y
   Madsen MSA, 2021, BIOMED PHARMACOTHER, V133, DOI 10.1016/j.biopha.2020.110966
   Makki K, 2018, CELL HOST MICROBE, V23, P705, DOI 10.1016/j.chom.2018.05.012
   Malaguarnera R., 2020, EXPLOR MED, V1, DOI [10.37349/emed.2020.00025, DOI 10.37349/EMED.2020.00025]
   Marizzoni M, 2020, FRONT MICROBIOL, V11, DOI 10.3389/fmicb.2020.01262
   Martin-Gallausiaux C, 2021, P NUTR SOC, V80, P37, DOI 10.1017/S0029665120006916
   Miossec Matthieu J, 2017, Curr Protoc Microbiol, V47, DOI 10.1002/cpmc.41
   Montandon SA, 2017, GENES-BASEL, V8, DOI 10.3390/genes8100250
   Moore JB, 2020, P NUTR SOC, V79, P300, DOI [10.1017/S0029665120006977[Opens, 10.1017/S0029665120006977]
   Motiani KK, 2020, MED SCI SPORT EXER, V52, P94, DOI 10.1249/MSS.0000000000002112
   Munoz-Garach A, 2016, ENDOCRINOL NUTR, V63, P560, DOI 10.1016/j.endonu.2016.07.008
   Napolitano M, 2020, FRONT MICROBIOL, V11, DOI 10.3389/fmicb.2020.590370
   Ng SC, 2022, GUT, V71, P716, DOI 10.1136/gutjnl-2020-323617
   Noriega DB, 2022, NUTRIENTS, V14, DOI 10.3390/nu14020371
   Palau-Rodriguez M, 2015, FRONT MICROBIOL, V6, DOI [10.3339/fmicb.2075.07751, 10.3389/fmicb.2015.01151]
   Pasini E, 2019, MINERVA MED, V110, P3, DOI 10.23736/S0026-4806.18.05589-1
   Pedersen C, 2016, BRIT J NUTR, V116, P1869, DOI 10.1017/S0007114516004086
   Peng GS, 2016, PHYSICA A, V443, P212, DOI 10.1016/j.physa.2015.09.023
   Pols TWH, 2011, DIGEST DIS, V29, P37, DOI 10.1159/000324126
   Popp D, 2020, FRONT BIOENG BIOTECH, V8, DOI 10.3389/fbioe.2020.00574
   Prodan A, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0227434
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Quevrain E, 2016, GUT, V65, P415, DOI 10.1136/gutjnl-2014-307649
   Reeves AE, 2012, INFECT IMMUN, V80, P3786, DOI 10.1128/IAI.00647-12
   Reijnders D, 2016, CELL METAB, V24, P63, DOI [10.1016/j.cmet.2016.06.016, 10.1016/j.cmet.2016.07.008]
   Ren MX, 2020, NUTRIENTS, V12, DOI 10.3390/nu12103036
   Rinninella E, 2019, MICROORGANISMS, V7, DOI 10.3390/microorganisms7010014
   Rios-Covian D, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.00376
   Rogier R, 2017, MICROBIOME, V5, DOI 10.1186/s40168-017-0278-2
   Rosario D, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.00775
   Ross MC, 2015, MICROBIOME, V3, DOI 10.1186/s40168-015-0072-y
   Sami W, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17030858
   Sanchez-Alcoholado L, 2019, SURG OBES RELAT DIS, V15, P1888, DOI 10.1016/j.soard.2019.08.551
   Sanchez-Alcoholado L, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.01936
   Schauer PR, 2017, CLEV CLIN J MED, V84, pS47, DOI 10.3949/ccjm.84.s1.06
   Schirmer M, 2016, CELL, V167, P1125, DOI 10.1016/j.cell.2016.10.020
   Schwager E, 2017, PLOS COMPUT BIOL, V13, DOI 10.1371/journal.pcbi.1005852
   Sethi JK, 2021, NAT METAB, V3, P1302, DOI 10.1038/s42255-021-00470-z
   Sharma S, 2019, J NUTR BIOCHEM, V63, P101, DOI 10.1016/j.jnutbio.2018.10.003
   Shaw GTW, 2016, BMC BIOINFORMATICS, V17, DOI 10.1186/s12859-016-1359-0
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Shoaie S, 2015, CELL METAB, V22, P320, DOI 10.1016/j.cmet.2015.07.001
   Shortt C, 2018, EUR J NUTR, V57, P25, DOI 10.1007/s00394-017-1546-4
   Sircana A, 2018, CURR DIABETES REP, V18, DOI 10.1007/s11892-018-1057-6
   Spranger J, 2003, DIABETES, V52, P812, DOI 10.2337/diabetes.52.3.812
   Swann JR, 2011, P NATL ACAD SCI USA, V108, P4523, DOI 10.1073/pnas.1006734107
   Thaiss CA, 2018, SCIENCE, V359, P1376, DOI 10.1126/science.aar3318
   Thiele I, 2020, MOL SYST BIOL, V16, DOI 10.15252/msb.20198982
   Thursby E, 2017, BIOCHEM J, V474, P1823, DOI 10.1042/BCJ20160510
   Tong XL, 2018, MBIO, V9, DOI 10.1128/mBio.02392-17
   Topcuoglu BD, 2020, MBIO, V11, DOI 10.1128/mBio.00434-20
   Tran KL, 2017, AM HEALTH DRUG BENEF, V10, P178
   Tungland B, 2018, HUMAN MICROBIOTA IN HEALTH AND DISEASE: PATHOGENESIS TO THERAPY, P37, DOI 10.1016/B978-0-12-814649-1.00002-8
   Utzschneider KM, 2016, J CLIN ENDOCR METAB, V101, P2622, DOI 10.1210/jc.2015-4251
   van Bommel EJM, 2020, DIABETES METAB, V46, P164, DOI 10.1016/j.diabet.2019.11.005
   van de Guchte M, 2018, MICROBIOME, V6, DOI 10.1186/s40168-018-0466-8
   Vernocchi P, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21103688
   Vijayan V, 2021, SENSORS-BASEL, V21, DOI 10.3390/s21165589
   Vrieze A, 2013, BEST PRACT RES CL GA, V27, P127, DOI 10.1016/j.bpg.2013.03.003
   Vrieze A, 2012, GASTROENTEROLOGY, V143, P913, DOI 10.1053/j.gastro.2012.06.031
   Wang H, 2020, FRONT CELL INFECT MI, V9, DOI 10.3389/fcimb.2019.00455
   Wang L, 2016, SCI REP-UK, V6, DOI [10.1038/srep38380, 10.1038/srep33251, 10.1038/srep20004]
   Wang XY, 2022, DIABETES OBES METAB, V24, P1132, DOI 10.1111/dom.14683
   Whang A, 2019, EBIOMEDICINE, V39, P591, DOI 10.1016/j.ebiom.2018.11.046
   Wilcox MH, 2020, OPEN FORUM INFECT DI, V7, DOI 10.1093/ofid/ofaa114
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Yan J, 2021, GUT MICROBES, V13, DOI 10.1080/19490976.2021.1984104
   Yan XF, 2016, J DIABETES RES, V2016, DOI 10.1155/2016/2093171
   Yang KL, 2021, GASTROENTEROLOGY, V161, P1257, DOI 10.1053/j.gastro.2021.06.056
   Yang Q, 2018, NAT REV MOL CELL BIO, V19, P654, DOI 10.1038/s41580-018-0044-8
   Zeevi D, 2015, CELL, V163, P1079, DOI 10.1016/j.cell.2015.11.001
   Zellmer C, 2021, CLIN INFECT DIS, V72, pE876, DOI 10.1093/cid/ciaa1486
   Zhang J, 2021, ADV SCI, V8, DOI 10.1002/advs.202100536
   Zhang LJ, 2020, AGING-US, V12, P17480, DOI 10.18632/aging.103756
   Zhang Q, 2020, DIABET METAB SYND OB, V13, P5003, DOI 10.2147/DMSO.S286430
   Zhang Q, 2018, EXP BIOL MED, V243, P34, DOI 10.1177/1535370217743765
   Zhang Q, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0184735
   Zhang X, 2019, MICROBIOME, V7, DOI 10.1186/s40168-019-0767-6
   Zhang X, 2015, SCI REP-UK, V5, DOI 10.1038/srep14405
   Zhao LJ, 2019, ENDOCRINE, V66, P526, DOI 10.1007/s12020-019-02103-8
   Zhao LP, 2018, SCIENCE, V359, P1151, DOI 10.1126/science.aao5774
   Zhao XJ, 2010, METABOLOMICS, V6, P362, DOI 10.1007/s11306-010-0203-1
   Zheng DP, 2020, CELL RES, V30, P492, DOI 10.1038/s41422-020-0332-7
   Zhou WY, 2019, NATURE, V569, P663, DOI 10.1038/s41586-019-1236-x
   Zmora N, 2019, NAT REV GASTRO HEPAT, V16, P35, DOI 10.1038/s41575-018-0061-2
   Zomorrodi AR, 2012, PLOS COMPUT BIOL, V8, DOI 10.1371/journal.pcbi.1002363
   Zomorrodi AR, 2014, ACS SYNTH BIOL, V3, P247, DOI 10.1021/sb4001307
NR 171
TC 6
Z9 6
U1 14
U2 42
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1949-0976
EI 1949-0984
J9 GUT MICROBES
JI Gut Microbes
PD DEC 31
PY 2022
VL 14
IS 1
AR 2111952
DI 10.1080/19490976.2022.2111952
PG 35
WC Gastroenterology & Hepatology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Microbiology
GA 3Z5GK
UT WOS:000844445100001
PM 36004400
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Hu, RX
   Yuan, YT
   Liu, CL
   Zhou, J
   Ji, LX
   Jiang, GH
AF Hu, Ruixin
   Yuan, Yanting
   Liu, Chaolong
   Zhou, Ji
   Ji, Lixia
   Jiang, Guohui
TI New insights into the links between anti-diabetes drugs and gut
   microbiota
SO ENDOCRINE CONNECTIONS
LA English
DT Review
DE gut microbiota; leaky gut; functional pancreatic beta-cells; short-chain
   fatty acids (SCFAs); anti-diabetes drugs; type 2 diabetes mellitus
   (T2DM)
ID METFORMIN; RESVERATROL; METAGENOME; SECRETION; ACARBOSE; BARRIER
AB In patients with type 2 diabetes mellitus (T2DM), the intestinal flora is out of balance and accompanied by leaky gut. The flora is characterized by an increase in mucus-degrading bacteria and a decrease in fiber-degrading bacteria. Short-chain fatty acids (SCFAs), as the major fiber-degrading bacteria fermentation, not only amelio rate the leaky gut, but also activate GPR43 to increase the mass of functional pancreatic beta-cells and exert anti-inflammation effect. At present, the gut microbiota is considered as the potential target for anti-diabetes drugs, and how to reverse the imbalance of gut microbiota has become a therapeutic strategy for T2DM. This review briefly summarizes the drugs or compounds that have direct or potential therapeutic effects on T2DM by modulating the gut microbiota, including biguanides, isoquinoline alkaloids, stilbene and C7N-aminocyclic alcohols.
C1 [Hu, Ruixin; Yuan, Yanting; Liu, Chaolong; Zhou, Ji; Ji, Lixia; Jiang, Guohui] Qing Dao Univ, Sch Pharm, Qingdao, Peoples R China.
C3 Qingdao University
RP Ji, LX; Jiang, GH (通讯作者)，Qing Dao Univ, Sch Pharm, Qingdao, Peoples R China.
EM lixiaji@163.com; 13370830026@163.com
RI Jiang, Guo/ISR-9858-2023
FU Introduced Talent Project of Qingdao University
   [80402010104/063-06301104]
FX This work was supported by grants from the Introduced Talent Project of
   Qingdao University (80402010104/063-06301104).
CR Bryrup T, 2019, DIABETOLOGIA, V62, P1024, DOI 10.1007/s00125-019-4848-7
   Camilleri M, 2019, GUT, V68, P1516, DOI 10.1136/gutjnl-2019-318427
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Chelakkot C, 2018, EXP MOL MED, V50, DOI 10.1038/emm.2017.282
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Desai MS, 2016, CELL, V167, P1339, DOI 10.1016/j.cell.2016.10.043
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Gu YY, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-01682-2
   Habtemariam S, 2020, PHARMACOL RES, V155, DOI 10.1016/j.phrs.2020.104722
   Hasain Z, 2020, FRONT CELL INFECT MI, V10, DOI 10.3389/fcimb.2020.00188
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kim TT, 2018, AM J PHYSIOL-ENDOC M, V315, pE511, DOI 10.1152/ajpendo.00471.2017
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Leiva-Gea I, 2018, DIABETES CARE, V41, P2385, DOI 10.2337/dc18-0253
   Massier L, 2020, GUT, V69, P1796, DOI 10.1136/gutjnl-2019-320118
   Miao XY, 2013, PEPTIDES, V39, P71, DOI 10.1016/j.peptides.2012.10.006
   Priyadarshini M, 2018, ENDOCRINOLOGY, V159, P2495, DOI 10.1210/en.2018-00296
   Priyadarshini M, 2016, TRENDS ENDOCRIN MET, V27, P653, DOI 10.1016/j.tem.2016.03.011
   Priyadarshini M, 2015, MOL ENDOCRINOL, V29, P1055, DOI 10.1210/me.2015-1007
   Psichas A, 2015, INT J OBESITY, V39, P424, DOI 10.1038/ijo.2014.153
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Shan CY, 2013, J ENDOCRINOL, V218, P255, DOI 10.1530/JOE-13-0184
   Shin NR, 2015, TRENDS BIOTECHNOL, V33, P496, DOI 10.1016/j.tibtech.2015.06.011
   Smith BJ, 2019, BMC MICROBIOL, V19, DOI 10.1186/s12866-019-1494-7
   Su BL, 2015, J DIABETES, V7, P729, DOI 10.1111/1753-0407.12232
   Sun HL, 2016, OBESITY FACTS, V9, P365, DOI 10.1159/000449507
   Sung MM, 2017, DIABETES, V66, P418, DOI 10.2337/db16-0680
   Tong XL, 2018, MBIO, V9, DOI 10.1128/mBio.02392-17
   Villa SR, 2016, SCI REP-UK, V6, DOI 10.1038/srep28159
   Wang P, 2020, INT J OBESITY, V44, P213, DOI 10.1038/s41366-019-0332-1
   Wang Y, 2017, METABOLISM, V70, P72, DOI 10.1016/j.metabol.2017.02.003
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Xu GD, 2018, BIOL PHARM BULL, V41, P1024, DOI 10.1248/bpb.b17-00978
   Yue SJ, 2019, AM J PHYSIOL-ENDOC M, V316, pE73, DOI 10.1152/ajpendo.00256.2018
   Zhang W, 2019, BIOMED PHARMACOTHER, V118, DOI 10.1016/j.biopha.2019.109131
   Zhang XY, 2017, DIABETES THER, V8, P293, DOI 10.1007/s13300-017-0226-y
NR 37
TC 2
Z9 3
U1 3
U2 19
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA STARLING HOUSE, 1600 BRISTOL PARKWAY N, BRISTOL, ENGLAND
SN 2049-3614
J9 ENDOCR CONNECT
JI Endocr. Connect.
PD JAN
PY 2021
VL 10
IS 1
BP R36
EP R42
DI 10.1530/EC-20-0431
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA QV2CT
UT WOS:000627785100004
PM 33338029
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Wu, XS
   Qian, SM
   Zhang, J
   Feng, JQ
   Luo, K
   Sun, LC
   Zhao, L
   Ran, YL
   Sun, L
   Wang, J
   Xu, FY
AF Wu, Xuesong
   Qian, Senmi
   Zhang, Jun
   Feng, Jieqiong
   Luo, Ke
   Sun, Lichao
   Zhao, Liang
   Ran, Yuliang
   Sun, Liang
   Wang, Jing
   Xu, Fangying
TI Lipopolysaccharide promotes metastasis via acceleration of glycolysis by
   the nuclear factor-kappa B/snail/hexokinase3 signaling axis in
   colorectal cancer
SO CANCER & METABOLISM
LA English
DT Article
DE Lipopolysaccharide; Inflammasome; Caspase-1; NF-&#954; B; Snail;
   Hexokinase 3; Colorectal cancer; Metastasis; Glycolysis; Metformin
ID NF-KAPPA-B; INFLAMMASOME ACTIVATION; GLUCOSE-METABOLISM; GUT MICROBIOTA;
   METFORMIN; NLRP3; SNAIL; ASSOCIATION; HEXOKINASE; RECEPTOR
AB Background Cancer cell is generally characterized by enhanced glycolysis. Inflammasome activation is interaction with glycolysis. The concentration of lipopolysaccharide (LPS), a classic inflammasome activator, is significantly higher in colorectal cancer tissue than in normal intestinal mucosa. However, the mechanism of LPS on glycolysis and metastasis has not been fully elucidated. This study aimed to investigate the roles of LPS on inflammasome activation, glycolysis, and metastasis, and unravel metformin's potential in treatment of CRC. Methods We detected inflammasome activation and cell motility following LPS exposure in CRC cell lines. Glycolysis analysis was performed, and the key glycolytic rate-limiting enzymes were detected. Dual-luciferase reporter gene assay, co-immunoprecipitation, chromatin immunoprecipitation (ChIP) analysis, and ChIP-reChIP assay were performed to identify the specific mechanisms of LPS on glycolysis. Mouse metastasis models were used to determine the effects of LPS and metformin on metastasis. Correlation analysis of the expression of various molecules was performed in 635 CRC samples from The Cancer Genome Atlas and 83 CRC samples from our lab. Results LPS activates caspase-1 through NF-kappa B and upregulates the expression of Snail and HK3 depending on caspase-1 activation. LPS potentiates migration and invasion depending on accelerated glycolysis, which could be reversed by knockdown of glycolytic rate-limiting enzyme HK3. Nuclear Snail is upregulated by NF-kappa B under LPS treatment and then forms a complex with NF-kappa B, then directly binds to the HK3 promoter region to upregulate the expression of HK3. Metformin suppresses the NF-kappa B/Snail/HK3 signaling axis that is activated by LPS and then inhibits LPS-induced metastasis. In vivo, LPS-treated cells form more metastasis in the lungs of mice, and metformin completely reverses this effect of LPS. Conclusion LPS activates inflammasomes in cancer cells through NF-kappa B and promotes metastasis through glycolysis enhanced by the NF-kappa B/Snail/HK3 signaling pathway in CRC. Metformin could prevent this effect of LPS.
C1 [Wu, Xuesong; Qian, Senmi; Zhang, Jun; Sun, Liang; Xu, Fangying] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Pathol & Pathophysiol, Hangzhou, Peoples R China.
   [Wu, Xuesong; Qian, Senmi; Zhang, Jun; Sun, Liang; Xu, Fangying] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Gen Surg, Hangzhou, Peoples R China.
   [Wu, Xuesong; Luo, Ke; Sun, Liang; Wang, Jing; Xu, Fangying] Zhejiang Univ, Sch Med, Key Lab Dis Prote Zhejiang Prov, Hangzhou, Peoples R China.
   [Wu, Xuesong] Zhejiang Univ, Med Sch, Affiliated Hosp 1, Dept Pathol, Hangzhou, Peoples R China.
   [Feng, Jieqiong] Zhejiang Prov Hosp Chinese Med, Dept Pathol, Hangzhou, Peoples R China.
   [Luo, Ke; Wang, Jing] Zhejiang Univ, Sch Med, Dept Pathol & Pathophysiol, Hangzhou, Peoples R China.
   [Sun, Lichao; Ran, Yuliang] Chinese Acad Med Sci & Peking Union Med Coll, State Key Lab Mol Oncol, Natl Canc Ctr, Canc Hosp, Beijing, Peoples R China.
   [Zhao, Liang] Shanghai Baoshan Luodian Hosp, Dept Pharm, Shanghai, Peoples R China.
C3 Zhejiang University; Zhejiang University; Zhejiang University; Zhejiang
   University; Zhejiang Chinese Medical University; Zhejiang University;
   Chinese Academy of Medical Sciences - Peking Union Medical College;
   Cancer Institute & Hospital - CAMS; Peking Union Medical College
RP Xu, FY (通讯作者)，Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Pathol & Pathophysiol, Hangzhou, Peoples R China.; Xu, FY (通讯作者)，Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Gen Surg, Hangzhou, Peoples R China.; Xu, FY (通讯作者)，Zhejiang Univ, Sch Med, Key Lab Dis Prote Zhejiang Prov, Hangzhou, Peoples R China.
EM xfy@zju.edu.cn
RI Wang, Juntao/O-4423-2015
OI Wang, Juntao/0000-0002-1822-2176
FU National Natural Science Foundation of China [81772570]; Natural Science
   Foundation of Zhejiang Province, China [LY17H160031]; Open Projects of
   State Key Laboratory of Molecular Oncology [SKLMO-KF2021-17]; Program of
   Introducing Talents of Discipline to Universities [B13026]
FX This work was supported by the grants of the National Natural Science
   Foundation of China under Grant 81772570, Natural Science Foundation of
   Zhejiang Province, China (LY17H160031), the Open Projects of State Key
   Laboratory of Molecular Oncology (SKLMO-KF2021-17), and Program of
   Introducing Talents of Discipline to Universities under Grant B13026.
CR Bailey CJ, 2008, DIABETOLOGIA, V51, P1552, DOI 10.1007/s00125-008-1053-5
   Bauer PV, 2018, CELL METAB, V27, P101, DOI 10.1016/j.cmet.2017.09.019
   Bhatt AP, 2017, CA-CANCER J CLIN, V67, P327, DOI 10.3322/caac.21398
   Bray Freddie, 2018, CA Cancer J Clin, V68, P394, DOI 10.3322/caac.21492
   Bridges KM, 2019, CURR COLORECT CANC R, V15, P70, DOI 10.1007/s11888-019-00431-5
   Cheng YF, 2020, CLIN RES HEPATOL GAS, V44, P73, DOI 10.1016/j.clinre.2019.06.009
   Dong CF, 2013, CANCER CELL, V23, P316, DOI 10.1016/j.ccr.2013.01.022
   Finucane OM, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-40619-1
   Gao Y, 2017, ONCOGENESIS, V6, DOI 10.1038/oncsis.2017.83
   Garza DR, 2020, CANCER METAB, V8, DOI 10.1186/s40170-020-0208-9
   Gatenby RA, 2004, NAT REV CANCER, V4, P891, DOI 10.1038/nrc1478
   Higurashi T, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00622
   Hornef MW, 2003, J EXP MED, V198, P1225, DOI 10.1084/jem.20022194
   Huang WS, 2018, J CELL BIOCHEM, V119, P6943, DOI 10.1002/jcb.26898
   Kang M, 2013, BMC CANCER, V13, DOI 10.1186/1471-2407-13-91
   Kim NH, 2017, NAT COMMUN, V8, DOI 10.1038/ncomms14374
   Kolb R, 2016, NAT COMMUN, V7, DOI 10.1038/ncomms13007
   Lee DJ, 2015, J INVEST DERMATOL, V135, P2012, DOI 10.1038/jid.2015.119
   Lee HM, 2013, DIABETES, V62, P194, DOI 10.2337/db12-0420
   Marini C, 2013, CELL CYCLE, V12, P3490, DOI 10.4161/cc.26461
   Martin-Montalvo A, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms3192
   Maslowski KM, 2009, NATURE, V461, P1282, DOI 10.1038/nature08530
   Prasad S, 2010, MOL CELL BIOCHEM, V336, P25, DOI 10.1007/s11010-009-0267-2
   Pryor R, 2019, CELL, V178, P1299, DOI 10.1016/j.cell.2019.08.003
   Pudova EA, 2018, BMC GENOMICS, V19, DOI 10.1186/s12864-018-4477-4
   Qiao Y, 2012, FEBS LETT, V586, P1022, DOI 10.1016/j.febslet.2012.02.045
   Routy B, 2018, SCIENCE, V359, P91, DOI 10.1126/science.aan3706
   Stanisavljevic J, 2011, J CELL SCI, V124, P4159, DOI 10.1242/jcs.078824
   Wolf AJ, 2016, CELL, V166, P624, DOI 10.1016/j.cell.2016.05.076
   Wu D, 2018, NATURE, V559, P637, DOI 10.1038/s41586-018-0350-5
   Wu WC, 2018, MOL PHARMACEUT, V15, P3272, DOI 10.1021/acs.molpharmaceut.8b00332
   Wu Y, 2009, CANCER CELL, V15, P416, DOI 10.1016/j.ccr.2009.03.016
   Wyatt E, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0013823
   Xie M, 2016, NAT COMMUN, V7, DOI 10.1038/ncomms13280
   Zhu B, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0176068
   Zhu GW, 2016, ONCOTARGET, V7, P73711, DOI 10.18632/oncotarget.12449
NR 36
TC 12
Z9 12
U1 1
U2 14
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 2049-3002
J9 CANCER METAB
JI Cancer Metab.
PD MAY 12
PY 2021
VL 9
IS 1
AR 23
DI 10.1186/s40170-021-00260-x
PG 16
WC Oncology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Cell Biology
GA SB0WQ
UT WOS:000649724000001
PM 33980323
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Xie, DD
   Zhao, XT
   Chen, MW
AF Xie, Dandan
   Zhao, Xiaotong
   Chen, Mingwei
TI Prevention and treatment strategies for type 2 diabetes based on
   regulating intestinal flora
SO BIOSCIENCE TRENDS
LA English
DT Review
DE type 2 diabetes mellitus; intestinal microbiota; insulin resistance;
   research progress
ID GUT MICROBIOTA; BARIATRIC SURGERY; INSULIN SENSITIVITY; METFORMIN
   TREATMENT; GLUCOSE; BIFIDOBACTERIA; METABOLISM; INCREASES; IMPACT
AB Diabetes along with related comorbidities associated with high disability rates severely threatens human health. The etiology of diabetes is complex. Genetics, environmental factors, eating habits, drug usage, aging, and lack of movement play important roles in the development of diabetes. Intestinal flora is reportedly closely related to the occurrence and development of type 2 diabetes. Herein, we review changes in abundance and proportion of intestinal flora in patients with type 2 diabetes and regulation of intestinal flora through diet, drugs, and surgery to prevent and treat type 2 diabetes. A more appropriate clinical diagnosis and treatment plan could be made considering changes in intestinal flora in the future.
C1 [Xie, Dandan; Zhao, Xiaotong; Chen, Mingwei] Anhui Med Univ, Dept Endocrinol, Affiliated Hosp 1, 218 Jixi Rd, Hefei 230032, Anhui, Peoples R China.
C3 Anhui Medical University
RP Chen, MW (通讯作者)，Anhui Med Univ, Dept Endocrinol, Affiliated Hosp 1, 218 Jixi Rd, Hefei 230032, Anhui, Peoples R China.
EM chmwl@163.com
CR Borody TJ, 2012, NAT REV GASTRO HEPAT, V9, P88, DOI 10.1038/nrgastro.2011.244
   Cani PD, 2007, DIABETOLOGIA, V50, P2374, DOI 10.1007/s00125-007-0791-0
   Cummings DE, 2018, DIABETOLOGIA, V61, P257, DOI 10.1007/s00125-017-4513-y
   Egshatyan L, 2016, ENDOCR CONNECT, V5, P1, DOI 10.1530/EC-15-0094
   Everard A, 2014, MBIO, V5, DOI 10.1128/mBio.01011-14
   Everard A, 2011, DIABETES, V60, P2775, DOI 10.2337/db11-0227
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Gao ZZ, 2017, J IMMUNOL RES, V2017, DOI 10.1155/2017/1813086
   Gu YY, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-01682-2
   Gurung M, 2020, EBIOMEDICINE, V51, DOI 10.1016/j.ebiom.2019.11.051
   Hartstra AV, 2015, DIABETES CARE, V38, P159, DOI 10.2337/dc14-0769
   Henao-Mejia J, 2012, NATURE, V482, P179, DOI 10.1038/nature10809
   Jiang ZL, 2020, BMC MED, V18, DOI 10.1186/s12916-020-01842-0
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kaska L, 2016, WORLD J GASTROENTERO, V22, P8698, DOI 10.3748/wjg.v22.i39.8698
   Khursheed R, 2020, INT J BIOL MACROMOL, V164, P1194, DOI 10.1016/j.ijbiomac.2020.07.145
   Kootte RS, 2017, CELL METAB, V26, P611, DOI 10.1016/j.cmet.2017.09.008
   Laitinen K, 2009, BRIT J NUTR, V101, P1679, DOI 10.1017/S0007114508111461
   Lambeth Stacey M, 2015, J Diabetes Obes, V2, P1
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Lean MEJ, 2019, NAT REV ENDOCRINOL, V15, P251, DOI 10.1038/s41574-019-0186-6
   Liu Y, 2020, CELL METAB, V31, P77, DOI 10.1016/j.cmet.2019.11.001
   Magouliotis DE, 2017, OBES SURG, V27, P1345, DOI 10.1007/s11695-017-2595-8
   Matacchione G, 2020, AGEING RES REV, V61, DOI 10.1016/j.arr.2020.101074
   McCreight LJ, 2016, DIABETOLOGIA, V59, P426, DOI 10.1007/s00125-015-3844-9
   McFarland LV, 2015, CLIN INFECT DIS, V60, pS85, DOI 10.1093/cid/civ054
   McLean MH, 2015, GUT, V64, P332, DOI [10.1136/gutjnl-2014-308514, 10.1136/gutjnl-2013-306499]
   Morita Y, 2020, DIABETES CARE, V43, P1796, DOI 10.2337/dc20-0093
   Moroti C, 2012, LIPIDS HEALTH DIS, V11, DOI 10.1186/1476-511X-11-29
   Murphy R, 2017, OBES SURG, V27, P917, DOI 10.1007/s11695-016-2399-2
   Palacios T, 2017, TRIALS, V18, DOI 10.1186/s13063-016-1762-x
   Pasini E, 2019, MINERVA MED, V110, P3, DOI 10.23736/S0026-4806.18.05589-1
   Pedersen HK, 2016, NATURE, V535, P376, DOI 10.1038/nature18646
   Perraudeau F, 2020, BMJ OPEN DIAB RES CA, V8, DOI 10.1136/bmjdrc-2020-001319
   Qin JJ, 2010, NATURE, V464, P59, DOI 10.1038/nature08821
   Reitmeier S, 2020, CELL HOST MICROBE, V28, P258, DOI 10.1016/j.chom.2020.06.004
   Rittiphairoj T, 2021, ADV NUTR, V12, P722, DOI 10.1093/advances/nmaa133
   Saeedi P, 2019, DIABETES RES CLIN PR, V157, DOI 10.1016/j.diabres.2019.107843
   Sanders ME, 2019, NAT REV GASTRO HEPAT, V16, P605, DOI 10.1038/s41575-019-0173-3
   Sedighi M, 2017, MICROB PATHOGENESIS, V111, P362, DOI 10.1016/j.micpath.2017.08.038
   Sroka-Oleksiak A, 2020, J CLIN MED, V9, DOI 10.3390/jcm9020369
   Su BL, 2015, J DIABETES, V7, P729, DOI 10.1111/1753-0407.12232
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Taddeo EP, 2020, DIABETES, V69, P131, DOI 10.2337/db19-0379
   Tong XL, 2018, MBIO, V9, DOI 10.1128/mBio.02392-17
   Vrieze A, 2012, GASTROENTEROLOGY, V143, P913, DOI 10.1053/j.gastro.2012.06.031
   Wu XK, 2010, CURR MICROBIOL, V61, P69, DOI 10.1007/s00284-010-9582-9
   Xu J, 2015, ISME J, V9, P552, DOI 10.1038/ismej.2014.177
   Zhang XY, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0071108
NR 49
TC 4
Z9 4
U1 21
U2 61
PU IRCA-BSSA
PI TOKYO
PA PEARL CITY KOISHIKAWA 603, 2-4-5 KASUGA, BUNKYO-KU, TOKYO, 112-0003,
   JAPAN
SN 1881-7815
EI 1881-7823
J9 BIOSCI TRENDS
JI BioSci. Trends
PD OCT
PY 2021
VL 15
IS 5
BP 313
EP 320
DI 10.5582/bst.2021.01275
PG 8
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA WX4FW
UT WOS:000718554600007
PM 34565781
OA gold
DA 2023-06-08
ER

PT J
AU Adeshirlarijaney, A
   Gewirtz, AT
AF Adeshirlarijaney, Aneseh
   Gewirtz, Andrew T.
TI Considering gut microbiota in treatment of type 2 diabetes mellitus
SO GUT MICROBES
LA English
DT Review
DE Diabetes; inflammation; microbiota metformin; dietary fiber
ID DIET-INDUCED OBESITY; HIGH-FAT DIET; INSULIN-RESISTANCE;
   FAECALIBACTERIUM-PRAUSNITZII; INTESTINAL MICROBIOTA; METABOLIC SYNDROME;
   LIPID-METABOLISM; GLUCOSE; METFORMIN; ASSOCIATION
AB Advances in the understanding of the pathogenesis of type 2 diabetes mellitus (T2D) have revealed a role for gut microbiota dysbiosis in driving this disease. This suggests the possibility that approaches to restore a healthy host-microbiota relationship might be a means of ameliorating T2D. Indeed, recent studies indicate that many currently used treatments for T2D are reported to impact gut microbiota composition. Such changes in gut microbiota may mediate and/or reflect the efficacy of these interventions. This article outlines the rationale for considering the microbiota as a central determent of development of T2D and, moreover, reviews evidence that impacting microbiota might be germane to amelioration of T2D, both in terms of understanding mechanisms that mediate efficacy of exiting T2D therapies and in developing novel treatments for this disorder.
C1 [Adeshirlarijaney, Aneseh; Gewirtz, Andrew T.] Georgia State Univ, Inst Biomed Sci, Atlanta, GA 30303 USA.
C3 University System of Georgia; Georgia State University
RP Gewirtz, AT (通讯作者)，Georgia State Univ, Inst Biomed Sci, Atlanta, GA 30303 USA.
EM agewirtz@gsu.edu
FU National Institute of Diabetes and Digestive and Kidney Diseases
   [DK099071]
FX This work was supported by the National Institute of Diabetes and
   Digestive and Kidney Diseases [grant number DK099071].
CR Adeshirlarijaney A, 2019, AM J PHYSIOL-ENDOC M, V317, pE1121, DOI 10.1152/ajpendo.00245.2019
   Alang N, 2015, OPEN FORUM INFECT DI, V2, DOI 10.1093/ofid/ofv004
   Andreasen AS, 2010, BRIT J NUTR, V104, P1831, DOI 10.1017/S0007114510002874
   Anhe FF, 2017, MOL METAB, V6, P1563, DOI 10.1016/j.molmet.2017.10.003
   Anhe FF, 2015, GUT, V64, P872, DOI 10.1136/gutjnl-2014-307142
   Backhed F, 2005, SCIENCE, V307, P1915, DOI 10.1126/science.1104816
   Backhed F, 2007, P NATL ACAD SCI USA, V104, P979, DOI 10.1073/pnas.0605374104
   BONORA E, 1984, CURR MED RES OPIN, V9, P47, DOI 10.1185/03007998409109558
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   Cani PD, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.01765
   Cani PD, 2013, BRIEF FUNCT GENOMICS, V12, P381, DOI 10.1093/bfgp/elt014
   Carvalho FA, 2012, CELL HOST MICROBE, V12, P139, DOI 10.1016/j.chom.2012.07.004
   Chassaing B, 2017, CELL MOL GASTROENTER, V4, P205, DOI 10.1016/j.jcmgh.2017.04.001
   Chen P, 2014, NUTRITION, V30, P1061, DOI 10.1016/j.nut.2014.03.022
   Dao MC, 2016, GUT, V65, P426, DOI 10.1136/gutjnl-2014-308778
   de Groot P, 2020, GUT, V69, P502, DOI 10.1136/gutjnl-2019-318320
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Ejtahed HS, 2016, HORM METAB RES, V48, P349, DOI 10.1055/s-0042-107792
   Ejtahed HS, 2019, EUR J ENDOCRINOL, V180, P165, DOI [10.1530/EJE-18-0826, 10.1530/eje-18-0826]
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Fuentes S, 2014, ISME J, V8, P1621, DOI 10.1038/ismej.2014.13
   Gao K, 2018, PHARMACOL RES, V130, P93, DOI 10.1016/j.phrs.2018.01.011
   Gerard C, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00029
   Hampe CS, 2017, ENDOCRINE, V58, P207, DOI 10.1007/s12020-017-1433-z
   Han JL, 2011, MED SCI MONITOR, V17, pRA164, DOI 10.12659/MSM.881842
   Han MM, 2019, ANN TRANSL MED, V7, DOI 10.21037/atm.2019.01.61
   Hariri M, 2015, GENES NUTR, V10, DOI 10.1007/s12263-015-0503-1
   Hawley SA, 2002, DIABETES, V51, P2420, DOI 10.2337/diabetes.51.8.2420
   Hill C, 2014, NAT REV GASTRO HEPAT, V11, P506, DOI 10.1038/nrgastro.2014.66
   Honda K, 2012, J CLIN BIOCHEM NUTR, V51, P96, DOI 10.3164/jcbn.11-07
   Huang GN, 2017, TOXICOL APPL PHARM, V332, P138, DOI 10.1016/j.taap.2017.04.009
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kootte RS, 2017, CELL METAB, V26, P611, DOI 10.1016/j.cmet.2017.09.008
   Kubota N, 2006, J BIOL CHEM, V281, P8748, DOI 10.1074/jbc.M505649200
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Li X, 2016, J APPL MICROBIOL, V121, P1727, DOI 10.1111/jam.13276
   Li XW, 2018, MOLECULES, V23, DOI 10.3390/molecules23123245
   Lin R, 2018, NUTR RES, V57, P67, DOI 10.1016/j.nutres.2018.05.004
   Liou AP, 2013, SCI TRANSL MED, V5, DOI 10.1126/scitranslmed.3005687
   Makki K, 2018, CELL HOST MICROBE, V23, P705, DOI 10.1016/j.chom.2018.05.012
   Moreira GV, 2018, J NUTR BIOCHEM, V62, P143, DOI 10.1016/j.jnutbio.2018.07.009
   Musi N, 2002, DIABETES, V51, P2074, DOI 10.2337/diabetes.51.7.2074
   Oshaghi EA, 2017, CRIT REV CL LAB SCI, V54, P267, DOI 10.1080/10408363.2017.1343274
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Razmpoosh E, 2016, DIABETES-METAB RES, V32, P143, DOI 10.1002/dmrr.2665
   Remely M, 2016, ENDOCR METAB IMMUNE, V16, P99, DOI 10.2174/1871530316666160831093813
   Rosario D, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.00775
   Shen Y, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-01619-1
   Shtriker MG, 2018, NUTRITION, V46, P134, DOI 10.1016/j.nut.2017.07.012
   Sokol H, 2009, INFLAMM BOWEL DIS, V15, P1183, DOI 10.1002/ibd.20903
   Song HZ, 2016, J GASTROEN HEPATOL, V31, P1462, DOI 10.1111/jgh.13278
   Song JX, 2017, FRONT PHYSIOL, V8, DOI 10.3389/fphys.2017.00602
   Stenman LK, 2014, BENEF MICROBES, V5, P437, DOI 10.3920/BM2014.0014
   Su BL, 2015, J DIABETES, V7, P729, DOI 10.1111/1753-0407.12232
   Tabuchi M, 2003, BIOSCI BIOTECH BIOCH, V67, P1421, DOI 10.1271/bbb.67.1421
   Trujillo ME, 2004, J CLIN ENDOCR METAB, V89, P5577, DOI 10.1210/jc.2004-0603
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Vallianou NG, 2019, HORM-INT J ENDOCRINO, V18, P141, DOI 10.1007/s42000-019-00093-w
   Van Hul M, 2018, AM J PHYSIOL-ENDOC M, V314, pE334, DOI 10.1152/ajpendo.00107.2017
   Vijay-Kumar M, 2010, SCIENCE, V328, P228, DOI 10.1126/science.1179721
   Vrieze A, 2012, GASTROENTEROLOGY, V143, P913, DOI 10.1053/j.gastro.2012.06.031
   Wang JH, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00620
   Wang L, 2016, SCI REP-UK, V6, DOI [10.1038/srep38380, 10.1038/srep33251, 10.1038/srep20004]
   Wellen KE, 2003, J CLIN INVEST, V112, P1785, DOI 10.1172/JCI20514
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Xie YQ, 2018, J DIABETES RES, V2018, DOI 10.1155/2018/4230590
   Yan X, 2019, J FOOD SCI, V84, P165, DOI 10.1111/1750-3841.14415
   Yan XF, 2016, J DIABETES RES, V2016, DOI 10.1155/2016/2093171
   Yang Q, 2018, AM J EPIDEMIOL, V187, P1916, DOI 10.1093/aje/kwy096
   Yassour M, 2016, GENOME MED, V8, DOI 10.1186/s13073-016-0271-6
   Yin YN, 2010, WORLD J GASTROENTERO, V16, P3394, DOI 10.3748/wjg.v16.i27.3394
   Yun SI, 2009, J APPL MICROBIOL, V107, P1681, DOI 10.1111/j.1365-2672.2009.04350.x
   Zhai BQ, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-21421-x
   Zhang BX, 2019, EVID-BASED COMPL ALT, V2019, DOI 10.1155/2019/2634898
   Zhang Q, 2018, EXP BIOL MED, V243, P34, DOI 10.1177/1535370217743765
   Zhang Q, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0184735
   Zhang X, 2012, PLOS ONE, V7, DOI [10.1371/journal.pone.0040320, 10.1371/journal.pone.0042529]
   Zhang XY, 2017, DIABETES THER, V8, P293, DOI 10.1007/s13300-017-0226-y
   Zhang XY, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0071108
   Zhang XQ, 2015, SCI REP-UK, V5, DOI 10.1038/srep10737
   Zou J, 2018, CELL HOST MICROBE, V23, P41, DOI 10.1016/j.chom.2017.11.003
NR 82
TC 64
Z9 65
U1 6
U2 51
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1949-0976
EI 1949-0984
J9 GUT MICROBES
JI Gut Microbes
PD MAY 3
PY 2020
VL 11
IS 3
BP 253
EP 264
DI 10.1080/19490976.2020.1717719
EA FEB 2020
PG 12
WC Gastroenterology & Hepatology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Microbiology
GA NL4BB
UT WOS:000512166500001
PM 32005089
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Jeong, DY
   Daily, JW
   Lee, GH
   Ryu, MS
   Yang, HJ
   Jeong, SY
   Qiu, JY
   Zhang, T
   Park, S
AF Jeong, Do Yeon
   Daily, James W.
   Lee, Gae Ho
   Ryu, Myeong Seon
   Yang, Hee-Jong
   Jeong, Seong-Yeop
   Qiu, Jing Yi
   Zhang, Ting
   Park, Sunmin
TI Short-Term Fermented Soybeans with Bacillus amyloliquefaciens
   Potentiated Insulin Secretion Capacity and Improved Gut Microbiome
   Diversity and Intestinal Integrity To Alleviate Asian Type 2 Diabetic
   Symptoms
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Article
DE type 2 diabetes; chungkookjang; Bacillus subtilis; Bacillus
   amyloliquefaciens; gut microbiome; insulin secretion
AB We determined that consuming chungkookjang fermented by Bacillus subtilis (BS) or Bacillus amyloliquefaciens (BA) alleviated hyperglycemia in partially pancreatectomized (Px) rats, an Asian type 2 diabetic (T2D) animal model. Px rats had deteriorated glucose metabolism with decreased glucose-stimulated insulin secretion and insulin sensitivity. Insulin secretion capacity was improved in the ascending order of the Px-control, positive control (3 mg of metformin/kg of body weight), BS (4.5% BS diet), BA (4.5% BA diet), and normal-control (sham-operated rats). BA and BS increased beta-cell mass and decreased malondialdehyde contents and tumor necrosis factor alpha expression in the islets. BA increased hepatic peroxisome proliferator-activated receptor (PPAR)-alpha and PPAR-beta similar to the positive control. Bacillales, Lactobacillales, and Verrucomicrobiales (Akkermensia muciniphila) increased and Enterobacteriales decreased in the BA and BS compared to the Px-control. BA prevented the decrease in the villi area and the number of goblet cells in intestinal tissues. In conclusion, BA improved glucose regulation by potentiating insulin secretion and reducing insulin resistance while maintaining gut mucin contents by improving gut microbiota in lean T2D rats.
C1 [Jeong, Do Yeon; Ryu, Myeong Seon; Yang, Hee-Jong; Jeong, Seong-Yeop; Qiu, Jing Yi] Sunchang Res Ctr Fermentat Microbes, Dept Res & Dev, Sunchang 56048, South Korea.
   [Daily, James W.] Daily Mfg Inc, Dept Res & Dev, Rockwell, NC 28138 USA.
   [Lee, Gae Ho] Korea Res Inst Analyt Technol KRIAT, Daejeon 34024, South Korea.
   [Qiu, Jing Yi; Zhang, Ting; Park, Sunmin] Hoseo Univ, Obes Diabet Res Ctr, Dept Food & Nutr, Asan 31499, South Korea.
C3 Hoseo University
RP Park, S (通讯作者)，Hoseo Univ, Obes Diabet Res Ctr, Dept Food & Nutr, Asan 31499, South Korea.
EM smpark@hoseo.edu
RI Park, Sun/GSD-9620-2022
OI Park, Sunmin/0000-0002-6092-8340
FU Traditional Culture Convergence Research Program through the National
   Research Foundation of Korea (NRF) - Ministry of Science and Information
   and Communications Technology (ICT) [NRF-2016M3C1B5907152]
FX This study was funded by a grant from the Traditional Culture
   Convergence Research Program through the National Research Foundation of
   Korea (NRF) funded by the Ministry of Science and Information and
   Communications Technology (ICT) (NRF-2016M3C1B5907152).
CR Ahn H, 2018, CELL MOL IMMUNOL, V15, P111, DOI 10.1038/cmi.2016.13
   Brunkwall L, 2017, DIABETOLOGIA, V60, P943, DOI 10.1007/s00125-017-4278-3
   Carmody RN, 2019, NAT MICROBIOL, V4, P2052, DOI 10.1038/s41564-019-0569-4
   Daily J, 2019, J PHYSIOL SCI, V69, P599, DOI 10.1007/s12576-019-00668-7
   Daily JW, 2019, J MED FOOD, V22, P127, DOI 10.1089/jmf.2018.4265
   Das D, 2018, BIOFACTORS, V44, P407, DOI 10.1002/biof.1439
   Dong HL, 2020, EUR J NUTR, V59, P719, DOI 10.1007/s00394-019-01939-0
   Heng Y, 2019, ARCH MICROBIOL, V201, P1009, DOI 10.1007/s00203-019-01665-5
   Iino C, 2019, NUTRIENTS, V11, DOI 10.3390/nu11020433
   Jeong SY, 2017, NUTRIENTS, V9, DOI 10.3390/nu9111200
   Kwon DY, 2007, EUR J NUTR, V46, P44, DOI 10.1007/s00394-006-0630-y
   Kwon JE, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0192490
   Lee DH, 2017, MOL NUTR FOOD RES, V61, DOI 10.1002/mnfr.201700322
   Lee MJ, 2019, FOOD CHEM, V289, P139, DOI 10.1016/j.foodchem.2019.02.133
   Lee SW, 2014, BIOCHEM BIOPH RES CO, V443, P413, DOI 10.1016/j.bbrc.2013.11.097
   Lim KH, 2012, FOOD CHEM TOXICOL, V50, P3941, DOI 10.1016/j.fct.2012.08.036
   Liu Y, 2020, CELL METAB, V31, P77, DOI 10.1016/j.cmet.2019.11.001
   Livak KJ, 2001, METHODS, V25, P402, DOI 10.1006/meth.2001.1262
   Nagpal R, 2018, J DIABETES RES, V2018, DOI 10.1155/2018/3462092
   Nguyen CT, 2017, EUR J CLIN NUTR, V71, P1186, DOI 10.1038/ejcn.2017.76
   Park S, 2006, J BIOL CHEM, V281, P1159, DOI 10.1074/jbc.M508307200
   Park S., 2018, KOREAN FUNCTIONAL FO, P145, DOI [10.1201/9781315156453-6, DOI 10.1201/9781315156453-6]
   Park SM, 2007, J APPL PHYSIOL, V103, P1764, DOI 10.1152/japplphysiol.00434.2007
   Park S, 2018, AM J PHYSIOL-ENDOC M, V315, pE99, DOI 10.1152/ajpendo.00005.2018
   Perez-Burillo S, 2018, J AGR FOOD CHEM, V66, P11500, DOI 10.1021/acs.jafc.8b04077
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Tomas-Barberan FA, 2016, CURR OPIN CLIN NUTR, V19, P471, DOI 10.1097/MCO.0000000000000314
   Torrens JI, 2004, DIABETES CARE, V27, P354, DOI 10.2337/diacare.27.2.354
   Walsh KR, 2007, AM J CLIN NUTR, V85, P1050, DOI 10.1093/ajcn/85.4.1050
   Yabe D, 2015, CURR DIABETES REP, V15, DOI 10.1007/s11892-015-0602-9
   Yang HJ, 2016, NUTRIENTS, V8, DOI 10.3390/nu8030161
   Yang HJ, 2015, EUR J NUTR, V54, P77, DOI 10.1007/s00394-014-0687-y
   Yoon KH, 2003, J CLIN ENDOCR METAB, V88, P2300, DOI 10.1210/jc.2002-020735
NR 33
TC 15
Z9 16
U1 4
U2 28
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
EI 1520-5118
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD NOV 18
PY 2020
VL 68
IS 46
BP 13168
EP 13178
DI 10.1021/acs.jafc.9b07962
PG 11
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA OW5JM
UT WOS:000592922700043
PM 32079403
DA 2023-06-08
ER

PT J
AU Xourgia, E
   Papazafiropoulou, A
   Papanas, N
   Melidonis, A
AF Xourgia, Eleni
   Papazafiropoulou, Athanasia
   Papanas, Nikolaos
   Melidonis, Andreas
TI Anti-diabetic treatment leads to changes in gut microbiome
SO FRONTIERS IN BIOSCIENCE-LANDMARK
LA English
DT Article
DE Anti-Diabetic Drugs; Dysbiosis; Gut Microbiota; Type 2 Diabetes
   Mellitus; Review
ID HIGH-FAT DIET; INTESTINAL MICROBIOTA; SGLT2 INHIBITORS; METFORMIN;
   OBESITY; MECHANISM; IMPROVEMENT; METABOLISM; METAGENOME; RECEPTOR
AB Numerous micro-organisms naturally reside in the human body assuming a symbiotic, or, at times, even a dysbiotic relationship with the host. These microbial populations are referred to as the human microbiota. Host microbial populations are an important mediator of gastro-intestinal mucosal permeability, bile acid metabolism, short-chain fatty acids synthesis, fermentation of dietary polysaccharides and FXR/TGR5 signaling. Variations in the composition and function of gut microbiota have been observed in type 2 diabetes mellitus, insulin resistance and obesity, as well as in inflammatory bowel diseases. The microbial imbalance induced by such pathological processes is described as dysbiosis. In this review, we describe the pathophysiological links between type 2 diabetes mellitus and gut microbiota, explore the effect of anti-diabetic drugs on gut microbiota and suggest possible therapeutic targets.
C1 [Xourgia, Eleni; Papazafiropoulou, Athanasia; Melidonis, Andreas] Tzaneio Gen Hosp Piraeus, Dept Internal Med 1, Diabet Ctr, Piraeus, Greece.
   [Papanas, Nikolaos] Democritus Univ Thrace, Univ Hosp Alexandroupolis, Dept Internal Med 2, Diabet Ctr, Xanthi, Greece.
C3 Democritus University of Thrace
RP Papazafiropoulou, A (通讯作者)，Tzaneio Gen Hosp Piraeus, Dept Internal Med 1, 1 Zanni & Afentouli St, Athens 18536, Greece.; Papazafiropoulou, A (通讯作者)，Tzaneio Gen Hosp Piraeus, Diabet Ctr, 1 Zanni & Afentouli St, Athens 18536, Greece.
EM pathan@ath.forthnet.gr
RI Xourgia, Eleni/AAO-7277-2020; Xourgia, Eleni/AAD-6822-2020
OI Xourgia, Eleni/0000-0001-5766-3209; 
CR BISCHOFF H, 1995, CLIN INVEST MED, V18, P303
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   Cani PD, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.01765
   Carding Simon, 2015, Microbial Ecology in Health and Disease, V26, P26191, DOI 10.3402/mehd.v26.26191
   Dalby MJ, 2017, CELL REP, V21, P1521, DOI 10.1016/j.celrep.2017.10.056
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Ding SL, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0012191
   Do HJ, 2016, ENDOCR J, V63, P691, DOI 10.1507/endocrj.EJ15-0747
   Du FY, 2018, J PHARMACOL EXP THER, V365, P676, DOI 10.1124/jpet.118.248575
   Enright Elaine F., 2016, Yale Journal of Biology and Medicine, V89, P375
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Graessler J, 2013, PHARMACOGENOMICS J, V13, P514, DOI 10.1038/tpj.2012.43
   Grasset E, 2017, CELL METAB, V25, P1075, DOI 10.1016/j.cmet.2017.04.013
   Gu YY, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-01682-2
   Jabbour SA, 2014, POSTGRAD MED, V126, P111, DOI 10.3810/pgm.2014.01.2731
   Jandhyala SM, 2015, WORLD J GASTROENTERO, V21, P8787, DOI 10.3748/wjg.v21.i29.8787
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kishida Y, 2017, J GASTROENTEROL, V52, P1180, DOI 10.1007/s00535-017-1331-4
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Lau E, 2015, HORM-INT J ENDOCRINO, V14, P358, DOI 10.14310/horm.2002.1571
   Lee DM, 2018, CARDIOVASC DIABETOL, V17, DOI 10.1186/s12933-018-0708-x
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Lepage P, 2017, REV MAL RESPIR, V34, P1085, DOI 10.1016/j.rmr.2016.11.003
   Lim MY, 2017, GUT, V66, P1031, DOI 10.1136/gutjnl-2015-311326
   Macfarlane S, 2003, P NUTR SOC, V62, P67, DOI 10.1079/PNS2002207
   MARUHAMA Y, 1980, TOHOKU J EXP MED, V132, P453, DOI 10.1620/tjem.132.453
   McCreight LJ, 2016, DIABETOLOGIA, V59, P426, DOI 10.1007/s00125-015-3844-9
   Meier JJ, 2012, NAT REV ENDOCRINOL, V8, P728, DOI 10.1038/nrendo.2012.140
   Rodriguez JM, 2015, MICROB ECOL HEALTH D, V26, DOI 10.3402/mehd.v26.26050
   Mishima E, 2018, AM J PHYSIOL-RENAL, V315, pF824, DOI 10.1152/ajprenal.00314.2017
   Napolitano A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100778
   Olivares M, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.01900
   Olivares M, 2018, DIABETOLOGIA, V61, P1838, DOI 10.1007/s00125-018-4647-6
   Pafili K, 2016, EXPERT OPIN INV DRUG, V25, P1133, DOI 10.1080/13543784.2016.1216970
   Palsson-McDermott EM, 2004, IMMUNOLOGY, V113, P153, DOI 10.1111/j.1365-2567.2004.01976.x
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Rena G, 2017, DIABETOLOGIA, V60, P1577, DOI 10.1007/s00125-017-4342-z
   Reveles KR, 2017, GUT
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Song RS, 2016, DIABETES CARE, V39, P187, DOI 10.2337/dci15-0013
   Su BL, 2015, J DIABETES, V7, P729, DOI 10.1111/1753-0407.12232
   Ticinesi A, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-10734-y
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Vella A, 2012, J CLIN ENDOCR METAB, V97, P2626, DOI 10.1210/jc.2012-2396
   Wang L, 2016, SCI REP-UK, V6, DOI [10.1038/srep38380, 10.1038/srep33251, 10.1038/srep20004]
   Wang Zhang, 2018, Endocrinol Diabetes Metab, V1, pe00009, DOI 10.1002/edm2.9
   Wehmeier UF, 2004, APPL MICROBIOL BIOT, V63, P613, DOI 10.1007/s00253-003-1477-2
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Yan XF, 2016, J DIABETES RES, V2016, DOI 10.1155/2016/2093171
   Zhang M, 2016, WORLD J GASTROENTERO, V22, P8905, DOI 10.3748/wjg.v22.i40.8905
   Zhang Q, 2018, EXP BIOL MED, V243, P34, DOI 10.1177/1535370217743765
   Zhang Q, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0184735
   Zhang XY, 2017, DIABETES THER, V8, P293, DOI 10.1007/s13300-017-0226-y
   Zhang XY, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0071108
   Zhang YJ, 2015, INT J MOL SCI, V16, P7493, DOI 10.3390/ijms16047493
   Zheng Y, 2018, NAT REV ENDOCRINOL, V14, P88, DOI 10.1038/nrendo.2017.151
NR 57
TC 14
Z9 17
U1 1
U2 23
PU IMR PRESS
PI ROBINSON
PA 112 ROBINSON RD, ROBINSON, SINGAPORE
SN 2768-6701
EI 2768-6698
J9 FRONT BIOSCI-LANDMRK
JI Front. Biosci.
PD JAN 1
PY 2019
VL 24
BP 688
EP 699
AR PMID 30844705
DI 10.2741/4743
PG 12
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA JB8IZ
UT WOS:000488812800005
PM 30844705
DA 2023-06-08
ER

PT J
AU Bronden, A
   Knop, FK
AF Bronden, Andreas
   Knop, Filip K.
TI Gluco-Metabolic Effects of Pharmacotherapy-Induced Modulation of Bile
   Acid Physiology
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Review
DE FXR; TGR5; ASBT; bile acid sequestrant; metformin
ID GLUCAGON-LIKE PEPTIDE-1; FARNESOID-X-RECEPTOR; TYPE-2 DIABETES-MELLITUS;
   TRANSPORTER INHIBITOR GSK2330672; NUCLEAR RECEPTOR; OBETICHOLIC ACID;
   ENTEROHEPATIC CIRCULATION; REDUCES ATHEROSCLEROSIS; INTRAVENOUS
   METFORMIN; INSULIN-SECRETION
AB Context: The discovery and characterization of the bile acid specific receptors farnesoid X receptor (FXR) and Takeda G protein-coupled receptor 5 (TGR5) have facilitated a wealth of research focusing on the link between bile acid physiology and glucose metabolism. Modulation of FXR and TGR5 activation have been demonstrated to affect the secretion of glucagon-like peptide 1, insulin, and glucagon as well as energy expenditure and gut microbiota composition, with potential beneficial effects on glucose metabolism.
   Evidence Acquisition: A search strategy based on literature searches in on PubMed with various combinations of the key words FXR, TGR5, agonist, apical sodium-dependent bile acid transporter (ASBT), bile acid sequestrant, metformin, and glucose metabolism has been applied to obtain material for the present review. Furthermore, manual searches including scanning of reference lists in relevant papers and conference proceedings have been performed.
   Evidence Synthesis: This review provides an outline of the link between bile acid and glucose metabolism, with a special focus on the gluco-metabolic impact of treatment modalities with modulating effects on bile acid physiology; including FXR agonists, TGR5 agonists, ASBT inhibitors, bile acid sequestrants, and metformin.
   Conclusions: Any potential beneficial gluco-metabolic effects of FXR agonists remain to be established, whereas the clinical relevance of TGR5-based treatment modalities seems limited because of substantial safety concerns of TGR5 agonists observed in animal models. The glucose-lowering effects of ASBT inhibitors, bile acid sequestrants, and metformin are at least partly mediated by modulation of bile acid circulation, which might allow an optimization of these bile acid-modulating treatment modalities.
C1 [Bronden, Andreas; Knop, Filip K.] Univ Copenhagen, Gentofte Hosp, Ctr Clin Metab Res, DK-2900 Hellerup, Denmark.
   [Knop, Filip K.] Univ Copenhagen, Fac Hlth & Med Sci, Dept Clin Med, DK-2200 Copenhagen N, Denmark.
   [Knop, Filip K.] Univ Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Ctr Basic Metab Res, DK-2200 Copenhagen N, Denmark.
   [Knop, Filip K.] Steno Diabet Copenhagen, DK-2820 Gentofte, Denmark.
C3 University of Copenhagen; Herlev & Gentofte Hospital; University of
   Copenhagen; University of Copenhagen
RP Knop, FK (通讯作者)，Gentofte Univ Hosp, Ctr Clin Metab Res, Gentofte Hosp Vej 7,3rd Floor, DK-2900 Hellerup, Denmark.
EM filip.krag.knop.01@regionh.dk
RI Knop, Filip K/GQI-2604-2022
OI Knop, Filip K/0000-0002-2495-5034; Bronden, Andreas/0000-0003-1262-3769
CR Abbing RLR, 2017, HEPATOLOGY, V66, p938A
   Adrian TE, 2012, DIABETOLOGIA, V55, P2343, DOI 10.1007/s00125-012-2593-2
   ADRIAN TE, 1993, GUT, V34, P1219, DOI 10.1136/gut.34.9.1219
   Agarwal S, 2016, ACS MED CHEM LETT, V7, P51, DOI 10.1021/acsmedchemlett.5b00323
   Amelsberg A, 1999, AM J PHYSIOL-GASTR L, V276, pG737, DOI 10.1152/ajpgi.1999.276.3.G737
   Amelsberg A, 1996, GASTROENTEROLOGY, V110, P1098, DOI 10.1053/gast.1996.v110.pm8612999
   Begley M, 2005, FEMS MICROBIOL REV, V29, P625, DOI 10.1016/j.femsre.2004.09.003
   Bentata Y, 2016, RENAL FAILURE, V38, P481, DOI 10.3109/0886022X.2016.1138837
   Beysen C, 2012, DIABETOLOGIA, V55, P432, DOI 10.1007/s00125-011-2382-3
   BONORA E, 1984, CURR MED RES OPIN, V9, P47, DOI 10.1185/03007998409109558
   Braunlin W, 2002, KIDNEY INT, V62, P611, DOI 10.1046/j.1523-1755.2002.00459.x
   Briere DA, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0136873
   Brighton CA, 2015, ENDOCRINOLOGY, V156, P3961, DOI 10.1210/en.2015-1321
   Broeders EPM, 2015, CELL METAB, V22, P418, DOI 10.1016/j.cmet.2015.07.002
   Bronden A, 2018, DIABETES OBES METAB, V20, P1623, DOI 10.1111/dom.13272
   Bronden A, 2018, DIABETES OBES METAB, V20, P362, DOI 10.1111/dom.13080
   Bronden A, 2017, J CLIN ENDOCR METAB, V102, P4153, DOI 10.1210/jc.2017-01091
   Brufau G, 2010, HEPATOLOGY, V52, P1455, DOI 10.1002/hep.23831
   Buse JB, 2016, DIABETES CARE, V39, P198, DOI 10.2337/dc15-0488
   Cai JS, 2014, J MEMBRANE BIOL, V247, P1067, DOI 10.1007/s00232-014-9715-3
   Cao H, 2016, SCI REP-UK, V6, DOI 10.1038/srep28676
   Carter D, 2003, DIABETES OBES METAB, V5, P120, DOI 10.1046/j.1463-1326.2003.00252.x
   Carter D, 2002, DIABETES OBES METAB, V4, P424, DOI 10.1046/j.1463-1326.2002.00223.x
   CASPARY WF, 1977, DIABETOLOGIA, V13, P187, DOI 10.1007/BF01219698
   Chatterjee S, 2017, LANCET, V389, P2239, DOI 10.1016/S0140-6736(17)30058-2
   Chen LH, 2012, AM J PHYSIOL-ENDOC M, V302, pE68, DOI 10.1152/ajpendo.00323.2011
   Cipriani S, 2010, J LIPID RES, V51, P771, DOI 10.1194/jlr.M001602
   Copple BL, 2016, PHARMACOL RES, V104, P9, DOI 10.1016/j.phrs.2015.12.007
   Cubbon R, 2008, INT J CLIN PRACT, V62, P287, DOI 10.1111/j.1742-1241.2007.01646.x
   Dawson PA, 2009, J LIPID RES, V50, P2340, DOI 10.1194/jlr.R900012-JLR200
   Denson LA, 2001, GASTROENTEROLOGY, V121, P140, DOI 10.1053/gast.2001.25503
   Duan HL, 2015, J MED CHEM, V58, P3315, DOI 10.1021/jm500829b
   FORMAN BM, 1995, CELL, V81, P687, DOI 10.1016/0092-8674(95)90530-8
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Gaede P, 2008, NEW ENGL J MED, V358, P580, DOI 10.1056/NEJMoa0706245
   Gormsen LC, 2016, J NUCL MED, V57, P1920, DOI 10.2967/jnumed.116.177774
   Haczeyni F, 2017, OBESITY, V25, P155, DOI 10.1002/oby.21701
   Hameed B, 2018, ALIMENT PHARM THER, V47, P645, DOI 10.1111/apt.14492
   Han CY, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19072069
   Hanniman EA, 2005, J LIPID RES, V46, P2595, DOI 10.1194/jlr.M500390-JLR200
   Hansen M, 2016, DIABETES OBES METAB, V18, P571, DOI 10.1111/dom.12648
   Hansen M, 2017, J DIABETES COMPLICAT, V31, P918, DOI 10.1016/j.jdiacomp.2017.01.011
   Hirst JA, 2012, DIABETES CARE, V35, P446, DOI 10.2337/dc11-1465
   Hodge RJ, 2016, DIABETES OBES METAB, V18, P439, DOI 10.1111/dom.12636
   Hodge RJ, 2013, CLIN PHARM DRUG DEV, V2, P213, DOI 10.1002/cpdd.34
   Hofmann AF, 2008, CELL MOL LIFE SCI, V65, P2461, DOI 10.1007/s00018-008-7568-6
   Hofmann AF, 2009, FRONT BIOSCI-LANDMRK, V14, P2584, DOI 10.2741/3399
   Holt JA, 2003, GENE DEV, V17, P1581, DOI 10.1101/gad.1083503
   Huff MW, 2002, ARTERIOSCL THROM VAS, V22, P1884, DOI 10.1161/01.ATV.0000035390.87288.26
   Hundal RS, 2003, DRUGS, V63, P1879, DOI 10.2165/00003495-200363180-00001
   Inagaki T, 2005, CELL METAB, V2, P217, DOI 10.1016/j.cmet.2005.09.001
   Inagaki T, 2006, P NATL ACAD SCI USA, V103, P3920, DOI 10.1073/pnas.0509592103
   Insull W, 2006, SOUTH MED J, V99, P257, DOI 10.1097/01.smj.0000208120.73327.db
   International Diabetes Federation, IDF DIABETES ATLAS
   Inzucchi SE, 2015, DIABETOLOGIA, V58, P429, DOI 10.1007/s00125-014-3460-0
   Islam KBMS, 2011, GASTROENTEROLOGY, V141, P1773, DOI 10.1053/j.gastro.2011.07.046
   Jurica J, 2016, PHYSIOL RES, V65, pS427, DOI 10.33549/physiolres.933512
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kawamata Y, 2003, J BIOL CHEM, V278, P9435, DOI 10.1074/jbc.M209706200
   Kissner T, 2015, DIABETES, V64, pA306
   Kliewer SA, 2015, DIGEST DIS, V33, P327, DOI 10.1159/000371670
   Kumar DP, 2016, J BIOL CHEM, V291, P6626, DOI 10.1074/jbc.M115.699504
   Kumar DP, 2012, BIOCHEM BIOPH RES CO, V427, P600, DOI 10.1016/j.bbrc.2012.09.104
   Kwong E, 2015, ACTA PHARM SIN B, V5, P151, DOI 10.1016/j.apsb.2014.12.009
   Lan T, 2013, ATHEROSCLEROSIS, V229, P374, DOI 10.1016/j.atherosclerosis.2013.05.017
   Lee H, 2006, J LIPID RES, V47, P201, DOI 10.1194/jlr.M500417-JLR200
   Lefebvre P, 2009, PHYSIOL REV, V89, P147, DOI 10.1152/physrev.00010.2008
   Li TT, 2011, MOL ENDOCRINOL, V25, P1066, DOI 10.1210/me.2010-0460
   Lundasen T, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0037787
   Ma K, 2006, J CLIN INVEST, V116, P1102, DOI 10.1172/JCI25604
   Ma YJ, 2013, PHARM RES-DORDR, V30, P1447, DOI 10.1007/s11095-013-0986-7
   Makishima M, 2002, SCIENCE, V296, P1313, DOI 10.1126/science.1070477
   Makishima M, 1999, SCIENCE, V284, P1362, DOI 10.1126/science.284.5418.1362
   Manne V, 2019, CURR OPIN GASTROEN, V35, P191, DOI 10.1097/MOG.0000000000000525
   Mannucci E, 2004, DIABETES NUTR METAB, V17, P336
   Mannucci E, 2001, DIABETES CARE, V24, P489, DOI 10.2337/diacare.24.3.489
   Marina AL, 2012, DIABETES CARE, V35, P1119, DOI 10.2337/dc11-2050
   Markham A, 2016, DRUGS, V76, P1221, DOI 10.1007/s40265-016-0616-x
   Martinot E, 2017, MOL ASPECTS MED, V56, P2, DOI 10.1016/j.mam.2017.01.006
   McCreight LJ, 2016, DIABETOLOGIA, V59, P426, DOI 10.1007/s00125-015-3844-9
   Molinaro A, 2018, TRENDS ENDOCRIN MET, V29, P31, DOI 10.1016/j.tem.2017.11.002
   Montandon SA, 2017, GENES-BASEL, V8, DOI 10.3390/genes8100250
   Mudaliar S, 2013, GASTROENTEROLOGY, V145, P574, DOI 10.1053/j.gastro.2013.05.042
   MYANT NB, 1977, J LIPID RES, V18, P135
   Nagahashi M, 2015, HEPATOLOGY, V61, P1216, DOI 10.1002/hep.27592
   Napolitano A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100778
   Neimark E, 2004, HEPATOLOGY, V40, P149, DOI 10.1002/hep.20295
   Neuschwander-Tetri BA, 2015, LANCET, V385, P956, DOI 10.1016/S0140-6736(14)61933-4
   Nevens F, 2016, NEW ENGL J MED, V375, P631, DOI 10.1056/NEJMoa1509840
   Nunez DJ, 2016, DIABETES OBES METAB, V18, P654, DOI 10.1111/dom.12656
   Ooi CP, 2014, DIABETIC MED, V31, P2, DOI 10.1111/dme.12295
   Parks DJ, 1999, SCIENCE, V284, P1365, DOI 10.1126/science.284.5418.1365
   Pathak P, 2018, HEPATOLOGY, V68, P1574, DOI 10.1002/hep.29857
   Pathak P, 2017, J BIOL CHEM, V292, P11055, DOI 10.1074/jbc.M117.784322
   Pols TWH, 2011, CELL METAB, V14, P747, DOI 10.1016/j.cmet.2011.11.006
   Poole DP, 2010, NEUROGASTROENT MOTIL, V22, DOI 10.1111/j.1365-2982.2010.01487.x
   Potthoff MJ, 2013, AM J PHYSIOL-GASTR L, V304, pG371, DOI 10.1152/ajpgi.00400.2012
   Prawitt J, 2014, TRENDS ENDOCRIN MET, V25, P235, DOI 10.1016/j.tem.2014.03.007
   Prawitt J, 2011, DIABETES, V60, P1861, DOI 10.2337/db11-0030
   Ren SL, 2014, AM J PHYSIOL-ENDOC M, V306, pE123, DOI 10.1152/ajpendo.00552.2013
   Ridlon JM, 2014, CURR OPIN GASTROEN, V30, P332, DOI 10.1097/MOG.0000000000000057
   RIFKIND BM, 1984, JAMA-J AM MED ASSOC, V251, P351
   Rohde U, 2016, J CLIN ENDOCR METAB, V101, P2076, DOI 10.1210/jc.2016-1133
   Sayegh AI, 2013, PROG MOL BIOL TRANSL, V114, P277, DOI 10.1016/B978-0-12-386933-3.00008-X
   Scarpello JHB, 1998, DIABETIC MED, V15, P651, DOI 10.1002/(SICI)1096-9136(199808)15:8<651::AID-DIA628>3.0.CO;2-A
   SCHJOLDAGER BTG, 1994, ANN NY ACAD SCI, V713, P207, DOI 10.1111/j.1749-6632.1994.tb44067.x
   Scorletti E, 2016, DIGEST DIS, V34, P11, DOI 10.1159/000447276
   Shneider BL, 2001, J PEDIATR GASTR NUTR, V32, P407, DOI 10.1097/00005176-200104000-00002
   Smushkin G, 2013, DIABETES, V62, P1094, DOI 10.2337/db12-0923
   Staels B, 2007, DRUGS, V67, P1383, DOI 10.2165/00003495-200767100-00001
   STARITZ M, 1988, ENDOSCOPY, V20, P171, DOI 10.1055/s-2007-1018170
   Staudinger JL, 2001, P NATL ACAD SCI USA, V98, P3369, DOI 10.1073/pnas.051551698
   SUM CF, 1992, DIABETIC MED, V9, P61, DOI 10.1111/j.1464-5491.1992.tb01716.x
   Suzuki Tatsuya, 2007, Journal of Nippon Medical School, V74, P338, DOI 10.1272/jnms.74.338
   Thomas C, 2009, CELL METAB, V10, P167, DOI 10.1016/j.cmet.2009.08.001
   Thondam SK, 2012, DIABETIC MED, V29, pE205, DOI 10.1111/j.1464-5491.2012.03675.x
   Trabelsi MS, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms8629
   Trauner M, 2010, DIGEST DIS, V28, P220, DOI 10.1159/000282091
   Ullmer C, 2013, BRIT J PHARMACOL, V169, P671, DOI 10.1111/bph.12158
   van Dijk TH, 2009, J BIOL CHEM, V284, P10315, DOI 10.1074/jbc.M807317200
   Wahlstrom A, 2017, DIGEST DIS, V35, P246, DOI 10.1159/000450982
   Wahlstrom A, 2016, CELL METAB, V24, P41, DOI 10.1016/j.cmet.2016.05.005
   Wang HB, 1999, MOL CELL, V3, P543, DOI 10.1016/S1097-2765(00)80348-2
   Wang YD, 2011, HEPATOLOGY, V54, P1421, DOI 10.1002/hep.24525
   Watanabe M, 2006, NATURE, V439, P484, DOI 10.1038/nature04330
   West KL, 2003, ATHEROSCLEROSIS, V171, P201, DOI 10.1016/j.atherosclerosis.2003.08.019
   West KL, 2002, J PHARMACOL EXP THER, V303, P293, DOI 10.1124/jpet.102.038711
   WHEELER HO, 1971, AM J MED, V51, P588, DOI 10.1016/0002-9343(71)90283-X
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Wu T, 2013, DIABETES OBES METAB, V15, P474, DOI 10.1111/dom.12043
   Wu TZ, 2013, J CLIN ENDOCR METAB, V98, pE718, DOI 10.1210/jc.2012-3961
   Wu YL, 2013, J MED CHEM, V56, P5094, DOI 10.1021/jm400459m
   Xie C, 2017, DIABETES, V66, P613, DOI 10.2337/db16-0663
   Xu X, 2018, METABOLISM, V85, P126, DOI 10.1016/j.metabol.2018.03.016
   Yamagata K, 2004, J BIOL CHEM, V279, P23158, DOI 10.1074/jbc.M314322200
   Zhang YQ, 2008, FEBS LETT, V582, P10, DOI 10.1016/j.febslet.2007.11.015
   Zhang YQ, 2006, ARTERIOSCL THROM VAS, V26, P2316, DOI 10.1161/01.ATV.0000235697.35431.05
   Zhang YQ, 2006, P NATL ACAD SCI USA, V103, P1006, DOI 10.1073/pnas.0506982103
   Zhou HP, 2014, STEROIDS, V86, P62, DOI 10.1016/j.steroids.2014.04.016
NR 139
TC 6
Z9 6
U1 2
U2 7
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD JAN
PY 2020
VL 105
IS 1
BP 362
EP 373
DI 10.1210/clinem/dgz025
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA KS2XC
UT WOS:000518172400034
PM 31630179
OA Bronze
DA 2023-06-08
ER

PT J
AU Ahmed, LA
   Salem, MB
   el-Din, SHS
   El-Lakkany, NM
   Ahmed, HO
   Nasr, SM
   Hammam, OA
   Botros, SS
   Saleh, S
AF Ahmed, Lamiaa A.
   Salem, Maha B.
   el-Din, Sayed H. Seif
   El-Lakkany, Naglaa M.
   Ahmed, Hend O.
   Nasr, Sami M.
   Hammam, Olfat A.
   Botros, Sanaa S.
   Saleh, Samira
TI Gut microbiota modulation as a promising therapy with metformin in rats
   with non-alcoholic steatohepatitis: Role of LPS/TLR4 and autophagy
   pathways
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE Autophagy; Lactobacillus reuteri; Metronidazole; Non-alcoholic
   steatohepatitis; Short chain fatty acids
ID FATTY LIVER-DISEASE; ACTIVATED PROTEIN-KINASE; LACTOBACILLUS-REUTERI;
   INSULIN-RESISTANCE; PCR; METRONIDAZOLE; CHOLESTEROL; MODEL; OBESE
AB Gut microbiota is a crucial factor in pathogenesis of non-alcoholic steatohepatitis (NASH). Therefore, targeting the gut-liver axis might be a novel therapeutic approach to treat NASH. This study aimed to investigate the therapeutic effects of a probiotic (Lactobacillus reuteri) and metronidazole (MTZ) (an antibiotic against Bacteroidetes) either alone or in combination with metformin (MTF) in experimentally-induced NASH. NASH was induced by feeding rats high fat diet (HFD) for 12 weeks. MTF (150 mg/kg/day) or L. reuteri (2x109 colony forming unit/day) were given orally for 8 weeks; meanwhile, MTZ (15 mg/kg/day, p.o.) was administered for 1 week. Treatment with L. reuteri and MTZ in combination with MTF showed additional benefit compared to MTF alone concerning lipid profile, liver function, oxidative stress, inflammatory and autophagic markers. Furthermore, combined regimen succeeded to modulate acetate: propionate: butyrate ratios as well as Firmicutes and Bacteroidetes fecal contents with improvement of insulin resistance (IR). Yet, the administration of MTF alone failed to normalize Bacteriodetes and acetate contents which could be the reason for its moderate effect. In conclusion, gut microbiota modulation may be an attractive therapeutic avenue against NASH. More attention should be paid to deciphering the crosstalk mechanisms linking gut microbiota to non-alcoholic fatty liver disease (NAFLD) to identify new therapeutic targets for this disease.
C1 [Ahmed, Lamiaa A.; Saleh, Samira] Cairo Univ, Fac Pharm, Pharmacol & Toxicol, Cairo, Egypt.
   [Salem, Maha B.; el-Din, Sayed H. Seif; El-Lakkany, Naglaa M.; Botros, Sanaa S.] Theodor Bilharz Res Inst, Pharmacol, Giza, Egypt.
   [Ahmed, Hend O.; Nasr, Sami M.] Theodor Bilharz Res Inst, Biochem, Giza, Egypt.
   [Hammam, Olfat A.] Theodor Bilharz Res Inst, Pathol, Giza, Egypt.
C3 Egyptian Knowledge Bank (EKB); Cairo University; Egyptian Knowledge Bank
   (EKB); Theodor Bilharz Research Institute (TBRI); Egyptian Knowledge
   Bank (EKB); Theodor Bilharz Research Institute (TBRI); Egyptian
   Knowledge Bank (EKB); Theodor Bilharz Research Institute (TBRI)
RP Ahmed, LA (通讯作者)，Fac Pharm, Kasr El Aini St, Cairo 11562, Egypt.
EM lamiaa.ahmed@pharma.cu.edu.eg; drmahabadr86@gmail.com;
   s.seifeldin@tbri.gov.eg; n.ellakkany@tbri.gov.eg; hend.oaa@gmail.com;
   samitbri@gmail.com; totoali1@hotmail.com; sanaabotros113@gmail.com;
   samira.saleh@pharma.cu.edu.eg
RI El-Lakkany, Naglaa/N-8249-2019; Ahmed, Hend Okasha/AAI-3806-2020; Nasr,
   Sami/HZK-6433-2023
OI El-Lakkany, Naglaa/0000-0002-5783-9945; Ahmed, Hend
   Okasha/0000-0003-1125-245X; Nasr, Sami/0000-0001-8683-3131; Botros,
   Sanaa/0000-0002-4131-0983
FU Theodor Bilharz Research Institute [117/A]
FX This work was supported by the internal research project 117/A (PI:
   Sayed Seif el-Din) for basic and applied research, a grant from Theodor
   Bilharz Research Institute.
CR Allin KH, 2015, EUR J ENDOCRINOL, V172, pR167, DOI 10.1530/EJE-14-0874
   Bashiardes S, 2016, MOL METAB, V5, P782, DOI 10.1016/j.molmet.2016.06.003
   Baxter NT, 2019, MBIO, V10, DOI [10.1128/mBio.02566-18, 10.1128/mbio.02566-18]
   Cani PD, 2013, CURR OPIN PHARMACOL, V13, P935, DOI 10.1016/j.coph.2013.09.008
   CAO SS, 1989, CANCER CHEMOTH PHARM, V24, P181, DOI 10.1007/BF00300240
   Ceccarelli S, 2015, ONCOTARGET, V6, P41434, DOI 10.18632/oncotarget.5163
   Chalasani N, 2018, HEPATOLOGY, V67, P328, DOI 10.1002/hep.29367
   Chambers ES, 2015, GUT, V64, P1744, DOI 10.1136/gutjnl-2014-307913
   Cui YJ, 2017, ONCOTARGET, V8, P77489, DOI 10.18632/oncotarget.20536
   Cusi K, 2009, CLIN LIVER DIS, V13, P545, DOI 10.1016/j.cld.2009.07.009
   Czaja MJ, 2016, DIGEST DIS SCI, V61, P1304, DOI 10.1007/s10620-015-4025-x
   El-Lakkany NM, 2016, RES PHARM SCI, V11, P374, DOI 10.4103/1735-5362.192487
   ELLMAN GL, 1959, ARCH BIOCHEM BIOPHYS, V82, P70, DOI 10.1016/0003-9861(59)90090-6
   Endo H, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0063388
   Fang WJ, 2019, J NUTR, V149, P747, DOI 10.1093/jn/nxy324
   Finlayson A, 2015, WORLD J GASTRO ENDOS, V7, P1103, DOI [10.4253/wjge.v7.i13.1103, 10.4291/wjgp.v6.i4.110]
   FREUND HR, 1985, J SURG RES, V38, P356, DOI 10.1016/0022-4804(85)90049-6
   Gagliardi A, 2018, INT J ENV RES PUB HE, V15, DOI 10.3390/ijerph15081679
   Guo X, 2008, LETT APPL MICROBIOL, V47, P367, DOI 10.1111/j.1472-765X.2008.02408.x
   Gutierrez-Rodelo C, 2017, GAC MED MEX, V153, P214
   Haak BW, 2019, J ANTIMICROB CHEMOTH, V74, P782, DOI 10.1093/jac/dky471
   Hajiaghamohammadi AA, 2012, HEPAT MON, V12, DOI 10.5812/hepatmon.6099
   Hathout AS, 2011, TOXICON, V58, P179, DOI 10.1016/j.toxicon.2011.05.015
   Hills RD, 2019, NUTRIENTS, V11, DOI 10.3390/nu11071613
   Hsieh FC, 2013, NUTR METAB, V10, DOI 10.1186/1743-7075-10-35
   Huang WC, 2015, NUTRIENTS, V7, P3767, DOI 10.3390/nu7053767
   Jakobsson HE, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009836
   Jenkins DJA, 2005, METABOLISM, V54, P103, DOI 10.1016/j.metabol.2004.07.019
   Khambu Bilon, 2018, Liver Res, V2, P112, DOI 10.1016/j.livres.2018.09.004
   Kirpich IA, 2008, ALCOHOL, V42, P675, DOI 10.1016/j.alcohol.2008.08.006
   Kleiner DE, 2005, HEPATOLOGY, V41, P1313, DOI 10.1002/hep.20701
   Krakoff J, 2010, OBESITY, V18, P1762, DOI 10.1038/oby.2010.21
   Kucukazman M, 2013, EUR J GASTROEN HEPAT, V25, P147, DOI 10.1097/MEG.0b013e32835a58b1
   Lau JKC, 2017, J PATHOL, V241, P36, DOI 10.1002/path.4829
   Layton A, 2006, APPL ENVIRON MICROB, V72, P4214, DOI 10.1128/AEM.01036-05
   Lee JH, 1999, INT J FOOD MICROBIOL, V50, P155, DOI 10.1016/S0168-1605(99)00086-0
   Ley RE, 2006, NATURE, V444, P1022, DOI 10.1038/4441022a
   Lin HZ, 2000, NAT MED, V6, P998, DOI 10.1038/79697
   Lin R, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00620
   Liu BB, 2020, BIOMED PHARMACOTHER, V125, DOI 10.1016/j.biopha.2020.109895
   Liu B, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0106184
   Liu K, 2013, CELL DEATH DIFFER, V20, P3, DOI 10.1038/cdd.2012.63
   Livak KJ, 2001, METHODS, V25, P402, DOI 10.1006/meth.2001.1262
   Loomba R, 2009, ALIMENT PHARM THER, V29, P172, DOI 10.1111/j.1365-2036.2008.03869.x
   LOWRY OH, 1951, J BIOL CHEM, V193, P265
   Marcher AB, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-39112-6
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   McCreight LJ, 2016, DIABETOLOGIA, V59, P426, DOI 10.1007/s00125-015-3844-9
   Meneghini LF, 2011, J CLIN ENDOCR METAB, V96, P3337, DOI 10.1210/jc.2011-1074
   Meng Y, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-44994-7
   Mobini R, 2017, DIABETES OBES METAB, V19, P579, DOI 10.1111/dom.12861
   Montandon SA, 2017, GENES-BASEL, V8, DOI 10.3390/genes8100250
   Morrison DJ, 2016, GUT MICROBES, V7, P189, DOI 10.1080/19490976.2015.1134082
   Musso G, 2012, DIABETOLOGIA, V55, P885, DOI 10.1007/s00125-011-2446-4
   Neuman M, 2012, INT J HEPATOL, V2012, DOI 10.1155/2012/429805
   OHKAWA H, 1979, ANAL BIOCHEM, V95, P351, DOI 10.1016/0003-2697(79)90738-3
   Ooi LG, 2010, J DAIRY SCI, V93, P5048, DOI 10.3168/jds.2010-3311
   Park BH, 2017, YONSEI MED J, V58, P756, DOI 10.3349/ymj.2017.58.4.756
   Pernicova I, 2014, NAT REV ENDOCRINOL, V10, P143, DOI 10.1038/nrendo.2013.256
   Sanches SCL, 2015, BIOMED RES INT, V2015, DOI 10.1155/2015/574832
   Sharma RS, 2018, CELL MOL GASTROENTER, V5, P367, DOI 10.1016/j.jcmgh.2017.11.016
   Shoaie S, 2013, SCI REP-UK, V3, DOI 10.1038/srep02532
   SMITH JA, 1980, CAN MED ASSOC J, V123, P202
   Song YM, 2015, AUTOPHAGY, V11, P46, DOI 10.4161/15548627.2014.984271
   Spruss A, 2009, HEPATOLOGY, V50, P1094, DOI 10.1002/hep.23122
   Venkatesan P., 2019, J DIABET COMPLICAT, V30, P287
   Wang BH, 2016, SCI REP-UK, V6, DOI 10.1038/srep32002
   Wang HJ, 2019, CELLS-BASEL, V8, DOI 10.3390/cells8121597
   Watson EJ, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-53183-5
   Woo SL, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0091111
   Yang YW, 2015, APPL ENVIRON MICROB, V81, P6749, DOI 10.1128/AEM.01906-15
   Zhou GC, 2001, J CLIN INVEST, V108, P1167, DOI 10.1172/JCI200113505
NR 72
TC 16
Z9 16
U1 3
U2 16
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0014-2999
EI 1879-0712
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD NOV 15
PY 2020
VL 887
AR 173461
DI 10.1016/j.ejphar.2020.173461
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA OH6SG
UT WOS:000582725000010
PM 32758573
DA 2023-06-08
ER

PT J
AU Sharma, B
   Kumar, A
   Sharma, U
   Pal, D
   Prashar, S
AF Sharma, Bunty
   Kumar, Aman
   Sharma, Ujjawal
   Pal, Deeksha
   Prashar, Sourabh
TI The Potential Role of Gut Microbiota in the Pathogenesis of Type 2
   Diabetes Mellitus via Epigenetics and Inflammasome
SO ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
LA English
DT Review
DE Microbiota; diabetes mellitus; epigenetics; inflammasome; dysbiosis; gut
ID CHAIN FATTY-ACIDS; DNA METHYLATION; INTESTINAL MICROBIOTA;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; METFORMIN ALTERS;
   GENE-EXPRESSION; GENOME-WIDE; PROTEIN; OBESITY
AB The gut microbiota that comprises over 100 trillion microorganisms with a weight of about 1-2 kg is regarded as one of the most crucial players in the regulation of the metabolic health of host organisms. In recent years, the incidence of type 2 diabetes mellitus (T2DM), characterized by high levels of sugar in the blood, has been exponentially increasing due to obesity and other lifestyle risk factors. It was shown that dysbiosis, change in the overall composition, and diversity of gut microflora can result in T2DM. Conversely, the microbial composition can also influence the epigenetics of the host organism (DNA methylation as well as histone modifications), which might have a potential effect on the metabolic health of the individual. Another mechanism of gut microbiota in the development of T2DM is through the involvement of nucleotide-binding oligomerization domain, Leucine-rich Repeat, and Pyrin domain containing 3 (NLRP3) inflammasome, a part of the innate immune system. NLRP3 inflammasome produces inflammatory cytokines, promoting the secretion of microbial antigens in the intestinal epithelium. Therefore, it is important to understand the possible connecting link between gut microbiota and T2DM that might help in the modulation of gut microflora to better understand the disease. In this review, the role of gut microbiota in the pathogenesis of T2DM will be discussed.
C1 [Sharma, Bunty] Chitkara Univ, Chitkara Sch Hlth Sci, Punjab, India.
   [Kumar, Aman; Sharma, Ujjawal; Prashar, Sourabh] Postgrad Inst Med Educ & Res, Community Med & Sch Publ Hlth, Chandigarh, India.
   [Pal, Deeksha] Postgrad Inst Med Educ & Res, Dept Translat & Regenerat Med, Chandigarh, India.
   [Sharma, Bunty; Sharma, Ujjawal] Maharishi Markandeshwar Deemed be Univ, Dept Biotechnol, Ambala, Haryana, India.
   [Sharma, Bunty; Kumar, Aman] Postgrad Inst Med Educ & Res, Sch Publ Hlth, Dept Community Med, Chandigarh, India.
C3 Chitkara University, Punjab; Post Graduate Institute of Medical
   Education & Research (PGIMER), Chandigarh; Post Graduate Institute of
   Medical Education & Research (PGIMER), Chandigarh; Post Graduate
   Institute of Medical Education & Research (PGIMER), Chandigarh
RP Sharma, B; Kumar, A (通讯作者)，Postgrad Inst Med Educ & Res, Sch Publ Hlth, Dept Community Med, Chandigarh, India.
RI Sharma, Ujjawal/E-7097-2013; Pal, DEEKSHA/HZI-5808-2023
OI Sharma, Ujjawal/0000-0002-2087-080X; Pal, DEEKSHA/0000-0002-3083-6170;
   Prashar, Saurabh/0000-0002-2813-2326
CR Amer Diabet Assoc, 2021, DIABETES CARE, V44, pS15, DOI 10.2337/dc21-S002
   Anderson JW, 2009, NUTR REV, V67, P188, DOI 10.1111/j.1753-4887.2009.00189.x
   Andreeva-Gateva PA, 2020, POSTGRAD MED, V132, P109, DOI 10.1080/00325481.2019.1681215
   Arora T, 2016, J INTERN MED, V280, P339, DOI 10.1111/joim.12508
   Bassols J, 2009, J CELL BIOCHEM, V107, P1107, DOI 10.1002/jcb.22208
   Bhat MI, 2017, NUTR REV, V75, P374, DOI 10.1093/nutrit/nux001
   Bianco-Miotto T, 2017, J DEV ORIG HLTH DIS, V8, P513, DOI 10.1017/S2040174417000733
   Bock PM, 2021, DIABETOLOGIA, V64, P26, DOI 10.1007/s00125-020-05295-1
   Brunkwall L, 2017, DIABETOLOGIA, V60, P943, DOI 10.1007/s00125-017-4278-3
   Burcelin R, 2016, MOL METAB, V5, P771, DOI 10.1016/j.molmet.2016.05.016
   Cao J, 2012, FRONT ONCOL, V2, DOI 10.3389/fonc.2012.00026
   Cao XW, 2020, CELL REP, V30, P4152, DOI 10.1016/j.celrep.2020.03.001
   Canizales YGC, 2018, IRAN J IMMUNOL, V15, P142, DOI IJIv15i2A7
   Cortese R, 2016, EPIGENETICS-US, V11, P205, DOI 10.1080/15592294.2016.1155011
   COUSENS LS, 1979, J BIOL CHEM, V254, P1716
   Ding SJ, 2019, BIOMOLECULES, V9, DOI 10.3390/biom9120850
   Ding T, 2014, NATURE, V509, P357, DOI 10.1038/nature13178
   Dirice E, 2017, J BIOL CHEM, V292, P17598, DOI 10.1074/jbc.M117.804328
   Dunachie S, 2019, T ROY SOC TROP MED H, V113, P56, DOI 10.1093/trstmh/try124
   Esser N, 2014, DIABETES RES CLIN PR, V105, P141, DOI 10.1016/j.diabres.2014.04.006
   Farrelly LA, 2019, NATURE, V567, P535, DOI 10.1038/s41586-019-1024-7
   Ferrucci L, 2018, NAT REV CARDIOL, V15, P505, DOI 10.1038/s41569-018-0064-2
   Fritzius T, 2007, FEBS J, V274, P1552, DOI 10.1111/j.1742-4658.2007.05702.x
   Funato H, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0018950
   Grice EA, 2011, NAT REV MICROBIOL, V9, P244, DOI 10.1038/nrmicro2537
   Gu HM, 2014, BBA-MOL CELL BIOL L, V1841, P847, DOI 10.1016/j.bbalip.2014.02.002
   Gu TW, 2014, J DIABETES METAB, V5, DOI 10.4172/2155-6156.1000419
   Guilherme A, 2008, NAT REV MOL CELL BIO, V9, P367, DOI 10.1038/nrm2391
   Gurung M, 2020, EBIOMEDICINE, V51, DOI 10.1016/j.ebiom.2019.11.051
   Han JH, 2018, DIABETES OBES METAB, V20, P2179, DOI 10.1111/dom.13350
   Hara S, 2001, BIOCHEM BIOPH RES CO, V287, P808, DOI 10.1006/bbrc.2001.5659
   Heredia VV, 2006, J BIOL CHEM, V281, P40201, DOI 10.1074/jbc.M607987200
   Hinnen Deborah, 2017, Diabetes Spectr, V30, P202, DOI 10.2337/ds16-0026
   Hoeppli RE, 2015, FRONT IMMUNOL, V6, DOI 10.3389/fimmu.2015.00061
   International Diabetes Federation, US
   Ismail L, 2021, COMPUT STRUCT BIOTEC, V19, P1759, DOI 10.1016/j.csbj.2021.03.003
   Jin HO, 2011, ONCOGENE, V30, P3792, DOI 10.1038/onc.2011.102
   Jung UJ, 2014, INT J MOL SCI, V15, P6184, DOI 10.3390/ijms15046184
   Kao KT, 2016, AUST FAM PHYSICIAN, V45, P401
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kasubuchi M, 2015, NUTRIENTS, V7, P2839, DOI 10.3390/nu7042839
   Kelley N, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20133328
   Khan S, 2014, CHEM-BIOL INTERACT, V213, P1, DOI 10.1016/j.cbi.2014.02.001
   Kim YA, 2018, NUTR RES REV, V31, P35, DOI 10.1017/S095442241700018X
   Kirkman MS, 2012, DIABETES CARE, V35, P2650, DOI 10.2337/dc12-1801
   Kumar A, 2019, INDIAN J CLIN BIOCHE, V34, P123, DOI 10.1007/s12291-019-00828-x
   Kumar H, 2014, MBIO, V5, DOI 10.1128/mBio.02113-14
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Liyanage NPM, 2007, EXP EYE RES, V85, P270, DOI 10.1016/j.exer.2007.05.001
   Mariat D, 2009, BMC MICROBIOL, V9, DOI 10.1186/1471-2180-9-123
   Maynard MA, 2005, FASEB J, V19, P1396, DOI 10.1096/fj.05-3788com
   Miao F, 2007, J BIOL CHEM, V282, P13854, DOI 10.1074/jbc.M609446200
   Mikula M, 2014, INT J MOL MED, V34, P1647, DOI 10.3892/ijmm.2014.1958
   Morgan XC, 2012, PLOS COMPUT BIOL, V8, DOI 10.1371/journal.pcbi.1002808
   Muka T, 2016, NUTR METAB CARDIOVAS, V26, P553, DOI 10.1016/j.numecd.2016.04.002
   Narang MA, 2004, HUM MOL GENET, V13, P15, DOI 10.1093/hmg/ddh006
   Netea MG, 2009, BLOOD, V113, P2324, DOI 10.1182/blood-2008-03-146720
   Nilsson E, 2014, DIABETES, V63, P2962, DOI 10.2337/db13-1459
   Pascal M, 2018, FRONT IMMUNOL, V9, DOI 10.3389/fimmu.2018.01584
   Pestinger V, 2011, J NUTR BIOCHEM, V22, P328, DOI 10.1016/j.jnutbio.2010.02.011
   Picca A, 2018, MEDIAT INFLAMM, V2018, DOI 10.1155/2018/7026198
   Prattichizzo F, 2018, AGEING RES REV, V41, P1, DOI 10.1016/j.arr.2017.10.003
   Prip-Buus C, 2001, MOL GENET METAB, V73, P46, DOI 10.1006/mgme.2001.3176
   Reginato MJ, 1999, TRENDS ENDOCRIN MET, V10, P9, DOI 10.1016/S1043-2760(98)00110-6
   Roberts SJ, 2004, BIOCHEM J, V382, P59, DOI 10.1042/BJ20040511
   Rong Y, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0073272
   Sabari BR, 2017, NAT REV MOL CELL BIO, V18, P90, DOI 10.1038/nrm.2016.140
   Sasaki M, 2013, BMC GASTROENTEROL, V13, DOI 10.1186/1471-230X-13-81
   Sathishkumar C, 2016, CLIN EPIGENETICS, V8, DOI 10.1186/s13148-016-0293-3
   Scheen AJ, 2018, CIRC RES, V122, P1439, DOI 10.1161/CIRCRESAHA.117.311588
   Sharma BR, 2019, EUR J IMMUNOL, V49, P1998, DOI 10.1002/eji.201848070
   Sharma D, 2016, J CELL BIOL, V213, P617, DOI 10.1083/jcb.201602089
   Sharma M, 2020, FRONT GENET, V10, DOI 10.3389/fgene.2019.01329
   Sharma P, 2016, INT J PREVENTIVE MED, V7, DOI 10.4103/2008-7802.188870
   Sheikh V, 2018, SCAND J IMMUNOL, V88, DOI 10.1111/sji.12711
   Shen Y, 2015, TRENDS PLANT SCI, V20, P614, DOI 10.1016/j.tplants.2015.07.005
   Sinclair K D, 2007, Soc Reprod Fertil Suppl, V64, P425
   Smith PM, 2013, SCIENCE, V341, P569, DOI 10.1126/science.1241165
   Sokol H, 2008, P NATL ACAD SCI USA, V105, P16731, DOI 10.1073/pnas.0804812105
   Soliman ML, 2012, J NEUROINFLAMM, V9, DOI 10.1186/1742-2094-9-51
   Stols-Goncalves D, 2019, CURR DIABETES REP, V19, DOI 10.1007/s11892-019-1151-4
   Sulfonamides,, 2012, LIVERTOX CLIN RES IN
   TAKEDA J, 1993, J BIOL CHEM, V268, P15200
   Tanaka T, 2009, BIOCHEM J, V424, P143, DOI 10.1042/BJ20090120
   Thorburn AN, 2014, IMMUNITY, V40, P833, DOI 10.1016/j.immuni.2014.05.014
   Ting X, 2019, NUCLEIC ACIDS RES, V47, P9721, DOI 10.1093/nar/gkz726
   Urakami T, 2019, DIABETES METAB SYNDR, V12, P1047, DOI 10.2147/DMSO.S179793
   Vahamiko S, 2019, EUR J NUTR, V58, P367, DOI 10.1007/s00394-017-1601-1
   Vangipurapu J, 2020, DIABETES CARE, V43, P1319, DOI 10.2337/dc19-2533
   Varemo L, 2017, GENOME MED, V9, DOI 10.1186/s13073-017-0432-2
   Vrieze A, 2012, GASTROENTEROLOGY, V143, P913, DOI 10.1053/j.gastro.2012.06.031
   Wang YG, 2009, J CELL SCI, V122, P4249, DOI 10.1242/jcs.050542
   Weisman A, 2018, CAN J CARDIOL, V34, P552, DOI 10.1016/j.cjca.2018.03.002
   Wen L, 2017, J NUTR, V147, p1468S, DOI 10.3945/jn.116.240754
   Wheatley KE, 2011, J OBES, V2011, DOI 10.1155/2011/265417
   Willeit P, 2017, DIABETES, V66, P347, DOI 10.2337/db16-0731
   Witalison EE, 2015, CURR DRUG TARGETS, V16, P700, DOI 10.2174/1389450116666150202160954
   Wu D, 2018, METABOLISM, V81, P1, DOI 10.1016/j.metabol.2017.10.015
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Yamaguchi Y, 2016, DIGESTION, V94, P66, DOI 10.1159/000447690
   Yang BT, 2011, DIABETOLOGIA, V54, P360, DOI 10.1007/s00125-010-1967-6
   Yilmaz P, 2014, NUCLEIC ACIDS RES, V42, pD643, DOI 10.1093/nar/gkt1209
   YOKOYAMA C, 1993, CELL, V75, P187, DOI 10.1016/S0092-8674(05)80095-9
   Youm YH, 2013, CELL METAB, V18, P519, DOI 10.1016/j.cmet.2013.09.010
   Yu DH, 2015, GENOME BIOL, V16, DOI 10.1186/s13059-015-0763-5
   Zaccardi F, 2020, LANCET, V396, P1705, DOI 10.1016/S0140-6736(20)32523-X
   Zhang PP, 2020, ACTA PHARMACOL SIN, V41, P678, DOI 10.1038/s41401-019-0330-9
   Zhang XY, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0071108
   Zhao WC, 2014, NEUROSCI LETT, V560, P81, DOI 10.1016/j.neulet.2013.12.019
   Zhao ZB, 2019, GENOME BIOL, V20, DOI 10.1186/s13059-019-1870-5
   Zhong T, 2017, ONCOGENE, V36, P2345, DOI 10.1038/onc.2016.391
NR 111
TC 0
Z9 0
U1 1
U2 9
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1871-5303
EI 2212-3873
J9 ENDOCR METAB IMMUNE
JI Endocr. Metab. Immune Disord.-Drug Targets
PY 2022
VL 22
IS 14
BP 1331
EP 1343
DI 10.2174/1871530322666220331152809
PG 13
WC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
GA 6Z8NZ
UT WOS:000898027900001
PM 35362379
DA 2023-06-08
ER

PT J
AU Que, YY
   Cao, M
   He, JQ
   Zhang, Q
   Chen, QY
   Yan, CS
   Lin, AQ
   Yang, LX
   Wu, ZZ
   Zhu, D
   Chen, FW
   Chen, ZR
   Xiao, CX
   Hou, KJ
   Zhang, BZ
AF Que, Yanyan
   Cao, Man
   He, Jianquan
   Zhang, Qiang
   Chen, Qiongyun
   Yan, Changsheng
   Lin, Aiqiang
   Yang, Luxi
   Wu, Zezhen
   Zhu, Dan
   Chen, Fengwu
   Chen, Zhangran
   Xiao, Chuanxing
   Hou, Kaijian
   Zhang, Bangzhou
TI Gut Bacterial Characteristics of Patients With Type 2 Diabetes Mellitus
   and the Application Potential
SO FRONTIERS IN IMMUNOLOGY
LA English
DT Article
DE microbiota; meta-analysis; T2DM; probiotics; 16S rRNA sequencing
ID INTESTINAL MICROBIOTA; ASSOCIATION; METAGENOME; DYSBIOSIS; METFORMIN;
   MARKERS; ADULTS
AB Type 2 diabetes mellitus (T2DM) is a complex disorder comprehensively influenced by genetic and environmental risk, and research increasingly has indicated the role of microbial dysbiosis in T2DM pathogenesis. However, studies comparing the microbiome characteristics between T2DM and healthy controls have reported inconsistent results. To further identify and describe the characteristics of the intestinal flora of T2DM patients, we performed a systematic review and meta-analysis of stool microbial profiles to discern and describe microbial dysbiosis in T2DM and to explore heterogeneity among 7 studies (600 T2DM cases, 543 controls, 1143 samples in total). Using a random effects model and a fixed effects model, we observed significant differences in beta diversity, but not alpha diversity, between individuals with T2DM and controls. We identified various operational taxonomic unit (OTUs) and bacterial genera with significant odds ratios for T2DM. The T2DM signatures derived from a single study by stepwise feature selection could be applied in other studies. By training on multiple studies, we improved the detection accuracy and disease specificity for T2DM. We also discuss the relationship between T2DM-enriched or T2DM-depleted genera and probiotics and provide new ideas for diabetes prevention and improvement.
C1 [Que, Yanyan] Xiamen Univ, Dept Endocrinol, Zhongshan Hosp, Xiamen, Peoples R China.
   [Cao, Man] Nanchang Univ, Sch Sci, Dept Math, Nanchang, Jiangxi, Peoples R China.
   [Cao, Man] Nanchang Univ, Sch Sci, Numer Simulat & High Performance Comp Lab, Nanchang, Jiangxi, Peoples R China.
   [He, Jianquan] Xiamen Univ, Dept Rehabil, Zhongshan Hosp, Xiamen, Peoples R China.
   [He, Jianquan; Xiao, Chuanxing] Fujian Univ Tradit Chinese Med, Sch Pharm, Fuzhou, Peoples R China.
   [Zhang, Qiang; Chen, Qiongyun; Yan, Changsheng; Chen, Zhangran; Zhang, Bangzhou] Xiamen Univ, Dept Gastroenterol, Zhongshan Hosp, Xiamen, Peoples R China.
   [Zhang, Qiang; Chen, Qiongyun; Yan, Changsheng; Yang, Luxi; Chen, Zhangran; Xiao, Chuanxing; Zhang, Bangzhou] Xiamen Univ, Sch Med, Xiamen, Peoples R China.
   [Lin, Aiqiang] Xiamen Treatgut Biotechnol Co Ltd, Dept Res & Dev, Xiamen, Peoples R China.
   [Wu, Zezhen; Zhu, Dan; Chen, Fengwu; Hou, Kaijian] Shantou Univ, Longhu Hosp, Dept Endocrine & Metab Dis, Affiliated Hosp 1,Med Coll, Shantou, Peoples R China.
   [Wu, Zezhen] Shantou Univ, Grad Sch, Med Coll, Shantou, Peoples R China.
C3 Xiamen University; Nanchang University; Nanchang University; Xiamen
   University; Fujian University of Traditional Chinese Medicine; Xiamen
   University; Xiamen University; Shantou University; Shantou University
RP Xiao, CX (通讯作者)，Fujian Univ Tradit Chinese Med, Sch Pharm, Fuzhou, Peoples R China.; Chen, ZR; Zhang, BZ (通讯作者)，Xiamen Univ, Dept Gastroenterol, Zhongshan Hosp, Xiamen, Peoples R China.; Chen, ZR; Xiao, CX; Zhang, BZ (通讯作者)，Xiamen Univ, Sch Med, Xiamen, Peoples R China.; Hou, KJ (通讯作者)，Shantou Univ, Longhu Hosp, Dept Endocrine & Metab Dis, Affiliated Hosp 1,Med Coll, Shantou, Peoples R China.
EM zhangran22105@xmu.edu.cn; xiaoxx@xmu.edu.cn; kaijianhou@126.com;
   geebzbz@xmu.edu.cn
RI Hou, Kaijian/AAY-4716-2021; Hou, Kaijian/GVU-1115-2022; Zhang,
   Bangzhou/CAG-9625-2022; Hou, Kaijian/AFP-0275-2022
OI Hou, Kaijian/0000-0003-1733-0068; Zhang, Qiang/0000-0002-4285-7964
CR Ahmad A, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0226372
   Allin KH, 2018, DIABETOLOGIA, V61, P810, DOI 10.1007/s00125-018-4550-1
   Auguie B., 2016, GRIDEXTRA MISCELLANE
   Ayelign B, 2019, J IMMUNOL RES, V2019, DOI 10.1155/2019/6196532
   Bruno G, 2005, DIABETES CARE, V28, P2613, DOI 10.2337/diacare.28.11.2613
   Candela M, 2016, BRIT J NUTR, V116, P80, DOI 10.1017/S0007114516001045
   Casqueiro Juliana, 2012, Indian J Endocrinol Metab, V16 Suppl 1, pS27, DOI 10.4103/2230-8210.94253
   Chavez-Carbajal A, 2020, MICROORGANISMS, V8, DOI 10.3390/microorganisms8010094
   Chavez-Carbajal A, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20020438
   Chen PC, 2019, NUTRITION, V63-64, P51, DOI 10.1016/j.nut.2018.11.019
   Crusell MKW, 2018, MICROBIOME, V6, DOI 10.1186/s40168-018-0472-x
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Deng XM, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.01607
   Doumatey AP, 2020, FRONT CELL INFECT MI, V10, DOI 10.3389/fcimb.2020.00063
   Duvallet C, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0222881
   Edgar RC, 2013, NAT METHODS, V10, P996, DOI [10.1038/nmeth.2604, 10.1038/NMETH.2604]
   Edgar RC, 2010, BIOINFORMATICS, V26, P2460, DOI 10.1093/bioinformatics/btq461
   Egshatyan L, 2016, ENDOCR CONNECT, V5, P1, DOI 10.1530/EC-15-0094
   Ejtahed HS, 2012, NUTRITION, V28, P539, DOI 10.1016/j.nut.2011.08.013
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Hashimoto Y, 2020, J DIABETES INVEST, V11, P1623, DOI 10.1111/jdi.13293
   Holman N, 2015, DIABETIC MED, V32, P1119, DOI 10.1111/dme.12791
   HUANG YA, 2021, BRIEF BIOINFORM, V22, DOI DOI 10.1093/BIB/BBAA133
   Inoue R, 2017, J CLIN BIOCHEM NUTR, V61, P217, DOI 10.3164/jcbn.17-44
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Lambeth Stacey M, 2015, J Diabetes Obes, V2, P1
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Leiva-Gea I, 2018, DIABETES CARE, V41, P2385, DOI 10.2337/dc18-0253
   Leylabadlo HE, 2020, INFECT GENET EVOL, V81, DOI 10.1016/j.meegid.2020.104268
   Li MY, 2014, BRIEF BIOINFORM, V15, P229, DOI 10.1093/bib/bbt027
   Li Q, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-62224-3
   Ma QT, 2019, BIOMED PHARMACOTHER, V117, DOI 10.1016/j.biopha.2019.109138
   Ma QT, 2018, MOLECULES, V23, DOI 10.3390/molecules23071834
   Mocanu V, 2021, NAT MED, V27, P1272, DOI 10.1038/s41591-021-01399-2
   Moher D, 2009, BMJ-BRIT MED J, V339, DOI [10.1136/bmj.i4086, 10.1136/bmj.g7647, 10.1136/bmj.b2535, 10.1186/2046-4053-4-1]
   Ni YC, 2018, DRUG DISCOV THER, V12, P161, DOI 10.5582/ddt.2018.01036
   Oksanen J., 2022, PACKAGE VEGAN COMMUN, DOI DOI 10.4135/9781412971874.N145
   Pietrucci D, 2020, BRAIN SCI, V10, DOI 10.3390/brainsci10040242
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   R Core Team, 2019, R LANG ENV STAT COMP
   Roden M, 2019, NATURE, V576, P51, DOI 10.1038/s41586-019-1797-8
   Ryan KK, 2014, NATURE, V509, P183, DOI 10.1038/nature13135
   Sabico S, 2019, CLIN NUTR, V38, P1561, DOI 10.1016/j.clnu.2018.08.009
   Saeedi P, 2019, DIABETES RES CLIN PR, V157, DOI 10.1016/j.diabres.2019.107843
   Salamon D, 2018, POL ARCH INTERN MED, V128, P336, DOI 10.20452/pamw.4246
   Sanna S, 2019, NAT GENET, V51, P600, DOI 10.1038/s41588-019-0350-x
   Sato J, 2014, DIABETES CARE, V37, P2343, DOI 10.2337/dc13-2817
   Sedighi M, 2017, MICROB PATHOGENESIS, V111, P362, DOI 10.1016/j.micpath.2017.08.038
   Shannon P, 2003, GENOME RES, V13, P2498, DOI 10.1101/gr.1239303
   Simon MC, 2015, DIABETES CARE, V38, P1827, DOI 10.2337/dc14-2690
   Sohail MU, 2017, J DIABETES RES, V2017, DOI 10.1155/2017/9631435
   Thingholm LB, 2019, CELL HOST MICROBE, V26, P252, DOI 10.1016/j.chom.2019.07.004
   Viechtbauer W, 2010, J STAT SOFTW, V36, P1, DOI 10.18637/jss.v036.i03
   Wade WG, 2006, PROKARYOTES: A HANDBOOK ON THE BIOLOGY OF BACTERIA, VOL 4, THIRD EDITION, P823, DOI 10.1007/0-387-30744-3_28
   Wang JJ, 2020, J DIABETES RES, V2020, DOI 10.1155/2020/6047145
   Wang XK, 2017, ANTON LEEUW INT J G, V110, P445, DOI 10.1007/s10482-016-0805-3
   Wang Y, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0172774
   Wickham H., 2016, PACKAGE GGPLOT2 CREA, DOI DOI 10.1016/J.SEPPUR.2018.11.065
   Wu XK, 2010, CURR MICROBIOL, V61, P69, DOI 10.1007/s00284-010-9582-9
   Yamaguchi Y, 2016, DIGESTION, V94, P66, DOI 10.1159/000447690
   Yang FW, 2019, MOLECULES, V24, DOI 10.3390/molecules24102003
   Zeuthen LH, 2006, CLIN VACCINE IMMUNOL, V13, P365, DOI 10.1128/CVI.13.3.365-375.2006
   Zhang XY, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0071108
   Zhang YW, 2019, BMC GENOMICS, V20, DOI 10.1186/s12864-019-6251-7
   Zhao LJ, 2019, ENDOCRINE, V66, P526, DOI 10.1007/s12020-019-02103-8
NR 65
TC 27
Z9 28
U1 4
U2 53
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-3224
J9 FRONT IMMUNOL
JI Front. Immunol.
PD AUG 12
PY 2021
VL 12
DI 10.3389/fimmu.2021.722206
PG 11
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA UN2EZ
UT WOS:000693834400001
PM 34484230
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Luck, H
   Khan, S
   Kim, JH
   Copeland, JK
   Revelo, XS
   Tsai, S
   Chakraborty, M
   Cheng, K
   Chan, YT
   Nohr, MK
   Clemente-Casares, X
   Perry, MC
   Ghazarian, M
   Lei, H
   Lin, YH
   Coburn, B
   Okrainec, A
   Jackson, T
   Poutanen, S
   Gaisano, H
   Allard, JP
   Guttman, DS
   Conner, ME
   Winer, S
   Winer, DA
AF Luck, Helen
   Khan, Saad
   Kim, Justin H.
   Copeland, Julia K.
   Revelo, Xavier S.
   Tsai, Sue
   Chakraborty, Mainak
   Cheng, Kathleen
   Chan, Yi Tao
   Nohr, Mark K.
   Clemente-Casares, Xavier
   Perry, Marie-Christine
   Ghazarian, Magar
   Lei, Helena
   Lin, Yi-Hsuan
   Coburn, Bryan
   Okrainec, Allan
   Jackson, Timothy
   Poutanen, Susan
   Gaisano, Herbert
   Allard, Johane P.
   Guttman, David S.
   Conner, Margaret E.
   Winer, Shawn
   Winer, Daniel A.
TI Gut-associated IgA(+) immune cells regulate obesity-related insulin
   resistance
SO NATURE COMMUNICATIONS
LA English
DT Article
ID T-CELLS; DENDRITIC CELLS; RETINOIC ACID; B-CELLS; MICROBIOTA;
   INFLAMMATION; LYMPHOCYTES; INTERLEUKIN-5; MACROPHAGES; GENERATION
AB The intestinal immune system is emerging as an important contributor to obesity-related insulin resistance, but the role of intestinal B cells in this context is unclear. Here, we show that high fat diet (HFD) feeding alters intestinal IgA(+) immune cells and that IgA is a critical immune regulator of glucose homeostasis. Obese mice have fewer IgA(+) immune cells and less secretory IgA and IgA-promoting immune mediators. HFD-fed IgA-deficient mice have dysfunctional glucose metabolism, a phenotype that can be recapitulated by adoptive transfer of intestinal-associated pan-B cells. Mechanistically, IgA is a crucial link that controls intestinal and adipose tissue inflammation, intestinal permeability, microbial encroachment and the composition of the intestinal microbiome during HFD. Current glucose-lowering therapies, including metformin, affect intestinal-related IgA(+) B cell populations in mice, while bariatric surgery regimen alters the level of fecal secretory IgA in humans. These findings identify intestinal IgA(+) immune cells as mucosal mediators of whole-body glucose regulation in diet-induced metabolic disease.
C1 [Luck, Helen; Khan, Saad; Kim, Justin H.; Tsai, Sue; Chakraborty, Mainak; Cheng, Kathleen; Chan, Yi Tao; Nohr, Mark K.; Clemente-Casares, Xavier; Ghazarian, Magar; Lei, Helena; Lin, Yi-Hsuan; Winer, Daniel A.] Univ Hlth Network, TGRI, Div Cellular & Mol Biol, Diabet Res Grp, Toronto, ON M5G 2C4, Canada.
   [Luck, Helen; Khan, Saad; Cheng, Kathleen; Chan, Yi Tao; Perry, Marie-Christine; Coburn, Bryan; Winer, Daniel A.] Univ Toronto, Dept Immunol, Toronto, ON M5S 1A8, Canada.
   [Copeland, Julia K.; Guttman, David S.] Univ Toronto, Ctr Anal Genome Evolut & Funct, Toronto, ON M5S 3B2, Canada.
   [Revelo, Xavier S.] Univ Minnesota, Dept Integrat Biol & Physiol, Minneapolis, MN 55455 USA.
   [Revelo, Xavier S.] Univ Minnesota, Ctr Immunol, Minneapolis, MN 55455 USA.
   [Tsai, Sue; Clemente-Casares, Xavier] Univ Alberta, Dept Med Microbiol & Immunol, Edmonton, AB T6G 2R3, Canada.
   [Lin, Yi-Hsuan] Chang Gung Univ, Coll Med, Ctr Tradit Chinese Med, Chang Gung Mem Hosp,Sch Tradit Chinese Med, Taoyuan 333, Taiwan.
   [Lin, Yi-Hsuan] Chang Gung Univ, Coll Med, Grad Inst Clin Med Sci, Taoyuan 333, Taiwan.
   [Coburn, Bryan] Univ Hlth Network, Dept Med, Div Infect Dis, Toronto, ON M5G 2N2, Canada.
   [Coburn, Bryan; Poutanen, Susan; Winer, Shawn; Winer, Daniel A.] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON M5S 1A8, Canada.
   [Okrainec, Allan; Jackson, Timothy] Univ Hlth Network, Toronto Western Hosp, Toronto, ON M5T 2S8, Canada.
   [Okrainec, Allan; Jackson, Timothy] Univ Toronto, Dept Surg, Toronto, ON M5T 1P5, Canada.
   [Poutanen, Susan; Gaisano, Herbert; Allard, Johane P.] Univ Toronto, Dept Med, Toronto, ON M5S 1A8, Canada.
   [Poutanen, Susan] Univ Hlth Network, Dept Microbiol, Sinai Hlth Syst, Toronto, ON M5G 2M9, Canada.
   [Allard, Johane P.] Univ Hlth Network, Toronto Gen Hosp, Toronto, ON M5G 2C4, Canada.
   [Conner, Margaret E.] Baylor Coll Med, Dept Virol & Microbiol, Houston, TX 77030 USA.
   [Winer, Shawn] St Michaels Hosp, Dept Lab Med, Toronto, ON M5B 1W8, Canada.
   [Winer, Daniel A.] Univ Hlth Network, Dept Pathol, 200 Elizabeth St, Toronto, ON M5G 2C4, Canada.
   [Winer, Daniel A.] Buck Inst Res Aging, 8001 Redwood Blvd, Novato, CA 94945 USA.
   [Luck, Helen; Khan, Saad; Winer, Daniel A.] 10-352 Toronto Med Discovery Tower,101 Coll St, Toronto, ON M5G 1L7, Canada.
C3 University of Toronto; University Health Network Toronto; University of
   Toronto; University of Toronto; University of Minnesota System;
   University of Minnesota Twin Cities; University of Minnesota System;
   University of Minnesota Twin Cities; University of Alberta; Chang Gung
   Memorial Hospital; Chang Gung University; Chang Gung University;
   University of Toronto; University Health Network Toronto; University of
   Toronto; University of Toronto; University Health Network Toronto;
   University of Toronto; University of Toronto; University of Toronto;
   Sinai Health System Toronto; Lunenfeld Tanenbaum Research Institute;
   University Health Network Toronto; University of Toronto; University
   Health Network Toronto; Toronto General Hospital; Baylor College of
   Medicine; University of Toronto; Saint Michaels Hospital Toronto;
   University of Toronto; University Health Network Toronto; Buck Institute
   for Research on Aging
RP Winer, DA (通讯作者)，Univ Hlth Network, TGRI, Div Cellular & Mol Biol, Diabet Res Grp, Toronto, ON M5G 2C4, Canada.; Winer, DA (通讯作者)，Univ Toronto, Dept Immunol, Toronto, ON M5S 1A8, Canada.; Winer, DA (通讯作者)，Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON M5S 1A8, Canada.; Winer, DA (通讯作者)，Univ Hlth Network, Dept Pathol, 200 Elizabeth St, Toronto, ON M5G 2C4, Canada.; Winer, DA (通讯作者)，Buck Inst Res Aging, 8001 Redwood Blvd, Novato, CA 94945 USA.; Winer, DA (通讯作者)，10-352 Toronto Med Discovery Tower,101 Coll St, Toronto, ON M5G 1L7, Canada.
EM dan.winer@uhn.ca
RI Okrainec, Allan/AAD-2260-2021; Revelo, Xavier/AAQ-9094-2020; Guttman,
   David S/A-7839-2011
OI Revelo, Xavier/0000-0002-2754-509X; Guttman, David
   S/0000-0001-8479-3869; Clemente-Casares, Xavier/0000-0002-8627-4971;
   Jackson, Timothy/0000-0001-8388-016X; Tsai, Sue/0000-0002-6261-5233;
   Nohr, Mark Klitgaard/0000-0002-5536-654X; Chakraborty,
   Mainak/0009-0002-2096-1389; Okrainec, Allan/0000-0003-1117-958X
FU Canadian Institutes of Health Research (CIHR) [119414, 142708, 148385];
   Diabetes Canada [OG-3-15-5014]; Canadian Liver Foundation (CLF); CIHR
   [303157]; Canada Research Chair; Ontario Ministry of Innovation Early
   Researcher Award; Queen Elizabeth II Graduate Scholarship in Science and
   Technology (QEII-GSST)/Aventis Pasteur; Banting and Best Diabetes Centre
   (BBDC) Graduate Scholarship; CIHR Canada Graduate Scholarship-Doctoral
   (CGS-D) Award; UTRS [152465]
FX We would like to kindly thank CAGEF at the University of Toronto for the
   gut microbiota sequencing, STTARR facility for the immunohistochemistry
   work, and Maryam Alghamdi, Carrie Li, Fariba Abedi, Monica L. Ponta,
   Aimee Paterson, and Melissa Kissoon for their work related to the
   bariatric human data, including study setup, patient screening,
   recruitment, visits, data and sample collections, and processing. This
   work is supported in part by Canadian Institutes of Health Research
   (CIHR) grants 119414, 142708, and 148385 (D.A.W.), Diabetes Canada grant
   OG-3-15-5014 (D.A.W.), and the Canadian Liver Foundation (CLF) (2017
   operating grant). The bariatric surgery research is supported by CIHR
   303157 and UTRS 152465. D.A.W. is a recipient of a Canada Research
   Chair, and the Ontario Ministry of Innovation Early Researcher Award.
   S.K. is a recipient of the Queen Elizabeth II Graduate Scholarship in
   Science and Technology (QEII-GSST)/Aventis Pasteur, and the Banting and
   Best Diabetes Centre (BBDC) Graduate Scholarship. H.L. is a recipient of
   the CIHR Canada Graduate Scholarship-Doctoral (CGS-D) Award.
CR Bhattacharya N, 2016, IMMUNITY, V45, P641, DOI 10.1016/j.immuni.2016.08.008
   Blutt SE, 2012, MUCOSAL IMMUNOL, V5, P712, DOI 10.1038/mi.2012.51
   Bokulich NA, 2013, NAT METHODS, V10, P57, DOI [10.1038/nmeth.2276, 10.1038/NMETH.2276]
   Caesar R, 2015, CELL METAB, V22, P658, DOI 10.1016/j.cmet.2015.07.026
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Caporaso JG, 2012, ISME J, V6, P1621, DOI 10.1038/ismej.2012.8
   Caporaso JG, 2010, NAT METHODS, V7, P335, DOI 10.1038/nmeth.f.303
   Castigli E, 2004, P NATL ACAD SCI USA, V101, P3903, DOI 10.1073/pnas.0307348101
   Cerovic V, 2015, MUCOSAL IMMUNOL, V8, P38, DOI 10.1038/mi.2014.40
   Cerutti A, 2008, NAT REV IMMUNOL, V8, P421, DOI 10.1038/nri2322
   Cerutti A, 2008, IMMUNITY, V28, P740, DOI 10.1016/j.immuni.2008.05.001
   Chassaing B, 2017, CELL MOL GASTROENTER, V4, P205, DOI 10.1016/j.jcmgh.2017.04.001
   CICALESE L, 1995, DIGEST DIS SCI, V40, P805, DOI 10.1007/BF02064983
   COFFMAN RL, 1989, J EXP MED, V170, P1039, DOI 10.1084/jem.170.3.1039
   Denning TL, 2007, NAT IMMUNOL, V8, P1086, DOI 10.1038/ni1511
   Ding SL, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0012191
   Dong CX, 2014, ENDOCRINOLOGY, V155, P370, DOI 10.1210/en.2013-1871
   Edgar RC, 2013, NAT METHODS, V10, P996, DOI [10.1038/nmeth.2604, 10.1038/NMETH.2604]
   Fadlallah J, 2018, SCI TRANSL MED, V10, DOI 10.1126/scitranslmed.aan1217
   Fagarasan S, 2010, ANNU REV IMMUNOL, V28, P243, DOI 10.1146/annurev-immunol-030409-101314
   Flores-Langarica A, 2018, MUCOSAL IMMUNOL, V11, P681, DOI 10.1038/mi.2017.105
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Fritz JH, 2012, NATURE, V481, P199, DOI 10.1038/nature10698
   Garidou L, 2015, CELL METAB, V22, P100, DOI 10.1016/j.cmet.2015.06.001
   Ghazarian M, 2017, SCI IMMUNOL, V2, DOI 10.1126/sciimmunol.aai7616
   Gutzeit C, 2014, IMMUNOL REV, V260, P76, DOI 10.1111/imr.12189
   Hong CP, 2017, GASTROENTEROLOGY, V152, P1998, DOI 10.1053/j.gastro.2017.02.016
   Horikawa K, 2006, IMMUNOLOGY, V118, P497, DOI 10.1111/j.1365-2567.2006.02382.x
   Hotamisligil GS, 2017, NATURE, V542, P177, DOI 10.1038/nature21363
   Johansen FE, 1999, J EXP MED, V190, P915, DOI 10.1084/jem.190.7.915
   Kato-Nagaoka N, 2015, IMMUNOLOGY, V146, P59, DOI 10.1111/imm.12480
   Kau AL, 2015, SCI TRANSL MED, V7, DOI 10.1126/scitranslmed.aaa4877
   Kawamoto S, 2014, IMMUNITY, V41, P152, DOI 10.1016/j.immuni.2014.05.016
   Kawano Y, 2016, CELL METAB, V24, P295, DOI 10.1016/j.cmet.2016.07.009
   Kim YI, 2018, J IMMUNOL, V201, P1287, DOI 10.4049/jimmunol.1701459
   Kubinak JL, 2015, CELL HOST MICROBE, V17, P153, DOI 10.1016/j.chom.2014.12.009
   Lin YH, 2019, INT J OBESITY, V43, P2407, DOI 10.1038/s41366-019-0340-1
   Luck H, 2015, CELL METAB, V21, P527, DOI 10.1016/j.cmet.2015.03.001
   Luda KM, 2016, IMMUNITY, V44, P860, DOI 10.1016/j.immuni.2016.02.008
   Macpherson AJ, 2004, SCIENCE, V303, P1662, DOI 10.1126/science.1091334
   Magouliotis DE, 2017, OBES SURG, V27, P1345, DOI 10.1007/s11695-017-2595-8
   Malik A, 2016, J CLIN INVEST, V126, P4469, DOI 10.1172/JCI88625
   Michael J Morgan, 2011, Cell Research, V21, P103
   Monteiro-Sepulveda M, 2015, CELL METAB, V22, P113, DOI 10.1016/j.cmet.2015.05.020
   Mora JR, 2006, SCIENCE, V314, P1157, DOI 10.1126/science.1132742
   Mortha A, 2014, SCIENCE, V343, P1477, DOI 10.1126/science.1249288
   Nadkarni MA, 2002, MICROBIOL-SGM, V148, P257, DOI 10.1099/00221287-148-1-257
   Nishimura S, 2009, NAT MED, V15, P914, DOI 10.1038/nm.1964
   Okai S, 2016, NAT MICROBIOL, V1, DOI [10.1038/nmicrobiol.2016.103, 10.1038/NMICROBIOL.2016.103]
   Pabst O, 2012, NAT REV IMMUNOL, V12, P821, DOI 10.1038/nri3322
   Palm NW, 2014, CELL, V158, P1000, DOI 10.1016/j.cell.2014.08.006
   Penny HL, 2016, CANCER IMMUNOL RES, V4, P917, DOI 10.1158/2326-6066.CIR-15-0038
   Price MN, 2009, MOL BIOL EVOL, V26, P1641, DOI 10.1093/molbev/msp077
   Rognes T, 2016, PEERJ, V4, DOI 10.7717/peerj.2584
   Segata N, 2011, GENOME BIOL, V12, DOI 10.1186/gb-2011-12-6-r60
   Seo GY, 2013, J LEUKOCYTE BIOL, V94, P325, DOI 10.1189/jlb.0313128
   Shen L, 2015, DIABETES, V64, P593, DOI 10.2337/db14-0554
   Shin NR, 2015, TRENDS BIOTECHNOL, V33, P496, DOI 10.1016/j.tibtech.2015.06.011
   SONODA E, 1989, J EXP MED, V170, P1415, DOI 10.1084/jem.170.4.1415
   Staley C, 2017, MICROBIOME, V5, DOI 10.1186/s40168-017-0306-2
   Stavnezer J, 2009, J IMMUNOL, V182, P5, DOI 10.4049/jimmunol.182.1.5
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Sun SC, 2011, CELL RES, V21, P71, DOI 10.1038/cr.2010.177
   Tokuyama H, 1999, CELL IMMUNOL, V192, P41, DOI 10.1006/cimm.1998.1438
   Tsai S, 2018, CELL METAB, V28, P922, DOI 10.1016/j.cmet.2018.08.003
   Tunis MC, 2015, CLIN EXP ALLERGY, V45, P1690, DOI 10.1111/cea.12605
   Vazquez-Baeza Y, 2013, GIGASCIENCE, V2, DOI 10.1186/2047-217X-2-16
   Wang Q, 2007, APPL ENVIRON MICROB, V73, P5261, DOI 10.1128/AEM.00062-07
   Wang XT, 2014, NATURE, V514, P237, DOI 10.1038/nature13564
   Winer DA, 2017, J CLIN INVEST, V127, P33, DOI 10.1172/JCI88879
   Winer DA, 2016, CELL METAB, V23, P413, DOI 10.1016/j.cmet.2016.01.003
   Winer DA, 2011, NAT MED, V17, P610, DOI 10.1038/nm.2353
   Winer S, 2009, NAT MED, V15, P921, DOI 10.1038/nm.2001
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
NR 74
TC 91
Z9 94
U1 11
U2 42
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
EI 2041-1723
J9 NAT COMMUN
JI Nat. Commun.
PD AUG 13
PY 2019
VL 10
AR 3650
DI 10.1038/s41467-019-11370-y
PG 17
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA IQ1OG
UT WOS:000480519600003
PM 31409776
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Wang, FJ
   Zhao, T
   Wang, WW
   Dai, QQ
   Ma, XH
AF Wang, Fujie
   Zhao, Ting
   Wang, Weiwei
   Dai, Qianqian
   Ma, Xianghua
TI Will intestinal flora therapy become a new target in type-2 diabetes
   mellitus? A review based on 13 clinical trials
SO NUTRICION HOSPITALARIA
LA English
DT Review
DE Intestinal flora; T2DM; Therapy
ID GUT MICROBIOTA; PROBIOTICS; INDIVIDUALS; METABOLITES; PREVALENCE;
   METFORMIN; BACTERIA; EXERCISE; ALTERS; ADULTS
AB Background: diabetes mellitus (DM) is a chronic disease and its pathogenesis is still inconclusive. Current evidence suggests an association between intestinal flora and type-2 diabetes mellitus (T2DM). In this paper, we summarized the current research, determining whether intestinal flora may become a new method to treat T2DM, and providing a theoretical basis and literature references for the prevention of T2DM based on the regulation of intestinal flora.
   Method: we carried out a review based on 13 published clinical trials to determine the correlation between T2DM and intestinal flora, and between changes in clinical outcomes and in intestinal flora in the development of T2DM; to assess the pathological mechanisms; and to discuss the treatment of diabetes based on intestinal flora.
   Results: we found that intestinal flora is involved in the occurrence and development of T2DM. Several pathological mechanisms may be involved in the process, including improving the gut barrier, alleviating inflammation, increasing glucagon-like peptide (GLP) 1 and GLP 2, increasing the production of short-chain fatty acids (SCFAs), and so on. Several measures based on intestinal flora, including exercise, food, specific diets, drugs and probiotics, would be used to treat and even prevent T2DM.
   Conclusions: high-quality studies are required to better understand the clinical effects of intestinal flora in T2DM.
C1 [Wang, Fujie; Zhao, Ting; Wang, Weiwei; Ma, Xianghua] Nanjing Med Univ, Affiliated Hosp 1, Nutr Dept, 300 Guangzhou Rd, Nanjing 210029, Peoples R China.
   [Dai, Qianqian] Xuzhou Canc Hosp, Nutr Dept, Xuzhou, Jiangsu, Peoples R China.
C3 Nanjing Medical University
RP Ma, XH (通讯作者)，Nanjing Med Univ, Affiliated Hosp 1, Nutr Dept, 300 Guangzhou Rd, Nanjing 210029, Peoples R China.
CR Adams CA, 2010, NUTR RES REV, V23, P37, DOI 10.1017/S0954422410000090
   Amar J, 2011, EMBO MOL MED, V3, P559, DOI 10.1002/emmm.201100159
   Balducci S, 2010, NUTR METAB CARDIOVAS, V20, P608, DOI 10.1016/j.numecd.2009.04.015
   Belkaid Y, 2014, CELL, V157, P121, DOI 10.1016/j.cell.2014.03.011
   Bruno G, 2005, DIABETES CARE, V28, P2613, DOI 10.2337/diacare.28.11.2613
   Cho NH, 2018, DIABETES RES CLIN PR, V138, P271, DOI 10.1016/j.diabres.2018.02.023
   David LA, 2014, NATURE, V505, P559, DOI 10.1038/nature12820
   Didari T, 2014, EXPERT OPIN DRUG SAF, V13, P227, DOI 10.1517/14740338.2014.872627
   Ding L, 2015, ACTA PHARM SIN B, V5, P135, DOI 10.1016/j.apsb.2015.01.004
   DRASAR BS, 1973, P NUTR SOC, V32, P49, DOI 10.1079/PNS19730014
   Earley ZM, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0129996
   Firouzi S, 2017, EUR J NUTR, V56, P1535, DOI 10.1007/s00394-016-1199-8
   Flint HJ, 2007, ENVIRON MICROBIOL, V9, P1101, DOI 10.1111/j.1462-2920.2007.01281.x
   Foligne B, 2016, FOOD MICROBIOL, V53, P60, DOI 10.1016/j.fm.2015.04.002
   Franceschi C, 2018, NAT REV ENDOCRINOL, V14, P576, DOI 10.1038/s41574-018-0059-4
   Gill SR, 2006, SCIENCE, V312, P1355, DOI 10.1126/science.1124234
   Gomes AC, 2014, NUTR J, V13, DOI 10.1186/1475-2891-13-60
   Goossens DAM, 2006, ALIMENT PHARM THER, V23, P255, DOI 10.1111/j.1365-2036.2006.02749.x
   Greenway F, 2014, BENEF MICROBES, V5, P29, DOI 10.3920/BM2012.0063
   He T, 2008, J APPL MICROBIOL, V104, P595, DOI 10.1111/j.1365-2672.2007.03579.x
   Heianza Y, 2019, GUT, V68, P263, DOI 10.1136/gutjnl-2018-316155
   Holman N, 2015, DIABETIC MED, V32, P1119, DOI 10.1111/dme.12791
   Hsieh MC, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-35014-1
   Inoguchi S, 2012, INT J FOOD SCI NUTR, V63, P402, DOI 10.3109/09637486.2011.630992
   Jeon J, 2019, NUTRIENTS, V11, DOI 10.3390/nu11010031
   Karlsson F, 2013, DIABETES, V62, P3341, DOI 10.2337/db13-0844
   Karusheva Y, 2019, AM J CLIN NUTR, V110, P1098, DOI 10.1093/ajcn/nqz191
   Kasubuchi M, 2015, NUTRIENTS, V7, P2839, DOI 10.3390/nu7042839
   Koenig JE, 2011, P NATL ACAD SCI USA, V108, P4578, DOI 10.1073/pnas.1000081107
   Lee Sang Kil, 2012, Korean J Gastroenterol, V60, P86
   Ley RE, 2006, NATURE, V444, P1022, DOI 10.1038/4441022a
   Liu Y, 2020, CELL METAB, V31, P77, DOI 10.1016/j.cmet.2019.11.001
   Lopez-Legarrea P, 2014, ASIA PAC J CLIN NUTR, V23, P360, DOI 10.6133/apjcn.2014.23.3.16
   Matsumoto K, 2010, J BIOSCI BIOENG, V110, P547, DOI 10.1016/j.jbiosc.2010.05.016
   Matsumoto M, 2008, BIOSCI BIOTECH BIOCH, V72, P572, DOI 10.1271/bbb.70474
   Noverr MC, 2004, TRENDS MICROBIOL, V12, P562, DOI 10.1016/j.tim.2004.10.008
   Palacios T, 2020, NUTRIENTS, V12, DOI 10.3390/nu12072041
   Palacios T, 2017, TRIALS, V18, DOI 10.1186/s13063-016-1762-x
   Pasini E, 2019, MINERVA MED, V110, P3, DOI 10.23736/S0026-4806.18.05589-1
   Puddu A, 2014, MEDIAT INFLAMM, V2014, DOI 10.1155/2014/162021
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   REDDY BS, 1975, J NUTR, V105, P878, DOI 10.1093/jn/105.7.878
   Ren MX, 2020, NUTRIENTS, V12, DOI 10.3390/nu12103036
   Renga B, 2010, BBA-MOL BASIS DIS, V1802, P363, DOI 10.1016/j.bbadis.2010.01.002
   Shen J, 2014, INFLAMM BOWEL DIS, V20, P21, DOI 10.1097/01.MIB.0000437495.30052.be
   Shyangdan DS, 2011, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD006423.pub2
   Song S, 2019, NUTRIENTS, V11, DOI 10.3390/nu11010008
   Tilg H, 2014, GUT, V63, P1513, DOI 10.1136/gutjnl-2014-306928
   Tong XL, 2018, MBIO, V9, DOI 10.1128/mBio.02392-17
   Voigt RM, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0097500
   Walker AW, 2011, ISME J, V5, P220, DOI 10.1038/ISMEJ.2010.118
   Wang LM, 2017, JAMA-J AM MED ASSOC, V317, P2515, DOI 10.1001/jama.2017.7596
   Wu GD, 2011, SCIENCE, V334, P105, DOI 10.1126/science.1208344
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Zhang YF, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-18414-8
   Zhao LP, 2018, SCIENCE, V359, P1151, DOI 10.1126/science.aao5774
   Zhong Yan, 2006, Wei Sheng Yan Jiu, V35, P587
   Zmora N, 2018, CELL, V174, P1388, DOI 10.1016/j.cell.2018.08.041
NR 58
TC 2
Z9 2
U1 15
U2 41
PU ARAN EDICIONES, S L
PI MADRID
PA C/ CASTELLO, 128, 1O, MADRID, 28006, SPAIN
SN 0212-1611
EI 1699-5198
J9 NUTR HOSP
JI Nutr. Hosp.
PD MAR-APR
PY 2022
VL 39
IS 2
BP 425
EP 433
DI 10.20960/nh.03866
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 3F3BO
UT WOS:000830544300023
PM 34844413
OA gold
DA 2023-06-08
ER

PT J
AU Smits, MM
   Fluitman, KS
   Herrema, H
   Davids, M
   Kramer, MHH
   Groen, AK
   Belzer, C
   de Vos, WM
   Cahen, DL
   Nieuwdorp, M
   van Raalte, DH
AF Smits, Mark M.
   Fluitman, Kristina S.
   Herrema, Hilde
   Davids, Mark
   Kramer, Mark H. H.
   Groen, Albert K.
   Belzer, Clara
   de Vos, Willem M.
   Cahen, Djuna L.
   Nieuwdorp, Max
   van Raalte, Daniel H.
TI Liraglutide and sitagliptin have no effect on intestinal microbiota
   composition: A 12-week randomized placebo-controlled trial in adults
   with type 2 diabetes
SO DIABETES & METABOLISM
LA English
DT Article
DE Dipeptidyl peptidase 4; DPP-4; Intestinal microbiota; GLP-1;
   Glucagon-like peptide 1
ID GUT MICROBIOTA; INSULIN SENSITIVITY; INDIVIDUALS
AB Aim: Preclinical data suggest that treatment with either glucagon-like peptide (GLP)-1 receptor agonists or dipeptidyl peptidase (DPP)-4 inhibitors could change the intestinal microbiome and thereby contribute to their beneficial (cardio)metabolic effects. Therefore, our study aimed to investigate the effects of these agents on microbiota composition in adults with type 2 diabetes (T2D).
   Methods: A total of 51 adults with T2D (mean +/- SD: age 62.8 +/- 6.9 years, BMI 31.8 +/- 4.1 kg/m(2), HbA(1c) 7.3 +/- 0.6%) treated with metformin and/or sulphonylureas were included in the 12-week randomized, double-blind trial. Patients were given the GLP-1 receptor agonist liraglutide (1.8 mg sc) or the DPP-4 inhibitor sitagliptin (100 mg), or matching placebos, once daily for 12 weeks. Faecal samples were collected at baseline and at 12 weeks after the start of the intervention. Microbiota analyses were performed by 16S rRNA gene-sequencing analysis. Bile acids were measured in faeces and plasma.
   Results: Liraglutide decreased HbA(1c) by 1.3% (95% CI: -1.7 to -0.9) and tended to reduce body weight (-1.7 kg, 95% CI: -3.6 to 0.3), but increased faecal secondary bile acid deoxycholic acid. Sitagliptin lowered HbA(1c) by 0.8% (95% CI: -1.4 to -0.4) while body weight remained stable (-0.8 kg, 95% CI: -2.7 to 1.0), but increased faecal levels of cholic acid, chenodeoxycholic acid and ursodeoxycholic acid. However, neither liraglutide nor sitagliptin affected either alpha or beta diversity of the intestinal microbiota, nor were changes in microbial composition related to clinical parameters.
   Conclusion: These data suggest that the beneficial effects of liraglutide and sitagliptin on glucose metabolism, body weight and bile acids, when used as add-on therapies to metformin or sulphonylureas, are not linked to changes in the intestinal microbiota (NCT01744236). (C) 2021 The Authors. Published by Elsevier Masson SAS.
C1 [Smits, Mark M.; Fluitman, Kristina S.; Kramer, Mark H. H.; Nieuwdorp, Max; van Raalte, Daniel H.] Amsterdam Univ Med Ctr, Diabet Ctr, Dept Internal Med, Locat VUmc, De Boelelaan 1117,Room ZH 4A65, NL-1081 HV Amsterdam, Netherlands.
   [Herrema, Hilde; Davids, Mark; Groen, Albert K.; Nieuwdorp, Max] Amsterdam Univ Med Ctr, Dept Vasc Med, Locat AMC, Amsterdam, Netherlands.
   [Belzer, Clara; de Vos, Willem M.] Wageningen Univ, Lab Microbiol, Wageningen, Netherlands.
   [de Vos, Willem M.] Univ Helsinki, Haartman Inst, Dept Bacteriol & Immunol, Dept Vet Biosci & RPU Immunobiol, Helsinki, Finland.
   [Cahen, Djuna L.] Erasmus MC, Dept Gastroenterol & Hepatol, Rotterdam, Netherlands.
C3 Wageningen University & Research; University of Helsinki; Erasmus
   University Rotterdam; Erasmus MC
RP Smits, MM (通讯作者)，Amsterdam Univ Med Ctr, Diabet Ctr, Dept Internal Med, Locat VUmc, De Boelelaan 1117,Room ZH 4A65, NL-1081 HV Amsterdam, Netherlands.
EM mm.smits1@amsterdamumc.nl
RI Kramer, Mark/GWQ-3502-2022; Smits, Mark/E-6573-2014; Belzer,
   Clara/P-6500-2018
OI Smits, Mark/0000-0001-8236-8842; Belzer, Clara/0000-0001-6922-836X; van
   Raalte, Daniel/0000-0003-2894-6124; Herrema, Hilde/0000-0002-0112-6348;
   Fluitman, Kristina/0000-0002-8579-369X; Davids, Mark/0000-0003-3081-9124
FU European Commission [282521]
FX The research leading to the present results was funded by the Seventh
   Framework Programme (FP7/2007-2013) of the European Commission under
   grant n 282521 (the SAFEGUARD project). Also, Novo Nordisk kindly
   provided the prefilled liraglutide and matching placebo pens. All of the
   researchers are independent of the funders, who had no role in the study
   design; in the collection, analysis and interpretation of the data; in
   the writing of the report; or in the decision to submit this article for
   publication.
CR Bates D, 2015, J STAT SOFTW, V67, P1, DOI 10.18637/jss.v067.i01
   Costea PI, 2017, NAT BIOTECHNOL, V35, P1069, DOI 10.1038/nbt.3960
   Edgar R. C., 2016, BIORXIV, DOI [10.1101/081257, DOI 10.1101/081257]
   Edgar RC, 2010, BIOINFORMATICS, V26, P2460, DOI 10.1093/bioinformatics/btq461
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Hartstra AV, 2015, DIABETES CARE, V38, P159, DOI 10.2337/dc14-0769
   Jung YA, 2014, DIABETES RES CLIN PR, V105, P47, DOI 10.1016/j.diabres.2014.04.028
   Kembel SW, 2010, BIOINFORMATICS, V26, P1463, DOI 10.1093/bioinformatics/btq166
   Klein T, 2014, MED MOL MORPHOL, V47, P137, DOI 10.1007/s00795-013-0053-9
   Kootte RS, 2017, CELL METAB, V26, P611, DOI 10.1016/j.cmet.2017.09.008
   Kozich JJ, 2013, APPL ENVIRON MICROB, V79, P5112, DOI 10.1128/AEM.01043-13
   McMurdie PJ, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0061217
   Moreira GV, 2018, J NUTR BIOCHEM, V62, P143, DOI 10.1016/j.jnutbio.2018.07.009
   Muskiet MHA, 2016, DIABETES OBES METAB, V18, P178, DOI 10.1111/dom.12601
   Oksanen J., 2019, **DATA OBJECT**, V2, P5
   Olivares M, 2018, DIABETOLOGIA, V61, P1838, DOI 10.1007/s00125-018-4647-6
   Quast C, 2013, NUCLEIC ACIDS RES, V41, pD590, DOI 10.1093/nar/gks1219
   Rohart F, 2017, PLOS COMPUT BIOL, V13, DOI 10.1371/journal.pcbi.1005752
   Sjoberg KA, 2015, J PHYSIOL-LONDON, V593, P2185, DOI 10.1113/JP270129
   Smits MM, 2016, DIABETES OBES METAB, V18, P1217, DOI 10.1111/dom.12748
   Smits MM, 2016, GUT, V65, P702, DOI 10.1136/gutjnl-2015-310572
   Smits MM, 2015, BMJ OPEN, V5, DOI 10.1136/bmjopen-2015-009579
   Sun F, 2015, J DIABETES RES, V2015, DOI 10.1155/2015/157201
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   ten Kulve JS, 2016, DIABETES CARE, V39, P214, DOI 10.2337/dc15-0772
   Tremaroli V, 2012, NATURE, V489, P242, DOI 10.1038/nature11552
   van Bloemendaal L, 2014, DIABETES, V63, P4186, DOI 10.2337/db14-0849
   Vrieze A, 2012, GASTROENTEROLOGY, V143, P913, DOI 10.1053/j.gastro.2012.06.031
   Wang L, 2016, SCI REP-UK, V6, DOI [10.1038/srep38380, 10.1038/srep33251, 10.1038/srep20004]
   Wang Q, 2007, APPL ENVIRON MICROB, V73, P5261, DOI 10.1128/AEM.00062-07
   Wang Zhang, 2018, Endocrinol Diabetes Metab, V1, pe00009, DOI 10.1002/edm2.9
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Yan XF, 2016, J DIABETES RES, V2016, DOI 10.1155/2016/2093171
   Zhao L, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00233
NR 34
TC 16
Z9 16
U1 0
U2 9
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 1262-3636
EI 1878-1780
J9 DIABETES METAB
JI Diabetes Metab.
PD SEP
PY 2021
VL 47
IS 5
AR 101223
DI 10.1016/j.diabet.2021.101223
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA WQ5SY
UT WOS:000713877100005
PM 33429063
OA Green Published, hybrid
DA 2023-06-08
ER

PT J
AU Pedersen, C
   Gallagher, E
   Horton, F
   Ellis, RJ
   Ijaz, UZ
   Wu, HH
   Jaiyeola, E
   Diribe, O
   Duparc, T
   Cani, PD
   Gibson, GR
   Hinton, P
   Wright, J
   La Ragione, R
   Robertson, MD
AF Pedersen, Camilla
   Gallagher, Edith
   Horton, Felicity
   Ellis, Richard J.
   Ijaz, Umer Z.
   Wu, Huihai
   Jaiyeola, Etana
   Diribe, Onyinye
   Duparc, Thibaut
   Cani, Patrice D.
   Gibson, Glenn R.
   Hinton, Paul
   Wright, John
   La Ragione, Roberto
   Robertson, M. Denise
TI Host-microbiome interactions in human type 2 diabetes following
   prebiotic fibre (galacto-oligosaccharide) intake
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Prebiotic supplements; Diabetes; Gut microbiota; Intestinal
   permeability; Endotoxaemia
ID GUT MICROBIOTA; RESISTANT STARCH; INSULIN-RESISTANCE; BLOOD-GLUCOSE;
   OBESITY; WOMEN; ENDOTOXEMIA; CONSUMPTION; FRUCTOOLIGOSACCHARIDES;
   SUPPLEMENTATION
AB Aberrant microbiota composition and function have been linked to several pathologies, including type 2 diabetes. In animal models, prebiotics induce favourable changes in the intestinal microbiota, intestinal permeability (IP) and endotoxaemia, which are linked to concurrent improvement in glucose tolerance. This is the first study to investigate the link between IP, glucose tolerance and intestinal bacteria in human type 2 diabetes. In all, twenty-nine men with well-controlled type 2 diabetes were randomised to a prebiotic (galacto-oligosaccharide mixture) or placebo (maltodextrin) supplement (5.5 g/d for 12 weeks). Intestinal microbial community structure, IP, endotoxaemia, inflammatory markers and glucose tolerance were assessed at baseline and post intervention. IP was estimated by the urinary recovery of oral Cr-51-EDTA and glucose tolerance by insulin-modified intravenous glucose tolerance test. Intestinal microbial community analysis was performed by high-throughput next-generation sequencing of 16S rRNA amplicons and quantitative PCR. Prebiotic fibre supplementation had no significant effects on clinical outcomes or bacterial abundances compared with placebo; however, changes in the bacterial family Veillonellaceae correlated inversely with changes in glucose response and IL-6 levels (r-0.90, P=0.042 for both) following prebiotic intake. The absence of significant changes to the microbial community structure at a prebiotic dosage/length of supplementation shown to be effective in healthy individuals is an important finding. We propose that concurrent metformin treatment and the high heterogeneity of human type 2 diabetes may have played a significant role. The current study does not provide evidence for the role of prebiotics in the treatment of type 2 diabetes.
C1 [Pedersen, Camilla; Wu, Huihai; Jaiyeola, Etana; Diribe, Onyinye; Wright, John; La Ragione, Roberto; Robertson, M. Denise] Univ Surrey, Fac Hlth & Med Sci, Guildford GU2 7XH, Surrey, England.
   [Gallagher, Edith; Horton, Felicity; Hinton, Paul] Royal Surrey Cty Hosp, Med Phys Nucl Med, Guildford GU2 7XX, Surrey, England.
   [Ellis, Richard J.] Anim & Plant Hlth Agcy, Addlestone KT15 3NB, Surrey, England.
   [Ijaz, Umer Z.] Univ Glasgow, Sch Engn, Glasgow G12 8LT, Lanark, Scotland.
   [Duparc, Thibaut; Cani, Patrice D.] Catholic Univ Louvain, Louvain Drug Res Inst, B-1200 Brussels, Belgium.
   [Gibson, Glenn R.] Univ Reading, Dept Food & Nutr Sci, Reading RG6 6AP, Berks, England.
   [Wright, John] Royal Surrey Cty Hosp, CEDAR Ctr, Guildford GU2 7XX, Surrey, England.
C3 University of Surrey; Royal Surrey County Hospital; Animal & Plant
   Health Agency UK; University of Glasgow; Universite Catholique Louvain;
   University of Reading; Royal Surrey County Hospital
RP Robertson, MD (通讯作者)，Univ Surrey, Fac Hlth & Med Sci, Guildford GU2 7XH, Surrey, England.
EM m.robertson@surrey.ac.uk
RI Ijaz, Umer Zeeshan Z/F-3583-2014; La Ragione, Roberto M/Q-9916-2017;
   Gibson, Glenn R/A-9595-2009; Ellis, Richard/A-9176-2008; D., Cani
   Patrice/M-8055-2016
OI Ijaz, Umer Zeeshan Z/0000-0001-5780-8551; La Ragione, Roberto
   M/0000-0001-5861-613X; Ellis, Richard/0000-0002-2690-9090; D., Cani
   Patrice/0000-0003-2040-2448; Christensen, Camilla/0000-0002-3253-124X;
   Thibaut, DUPARC/0000-0002-6058-4656
FU EFSD clinical research grant; National Institute for Health Research
   Clinical Research Network: Kent, Surrey and Sussex; Natural Environment
   Research Council [NE/L011956/1] Funding Source: researchfish; NERC
   [NE/L011956/1] Funding Source: UKRI
FX This study was funded by an EFSD clinical research grant. The research
   was supported by the National Institute for Health Research Clinical
   Research Network: Kent, Surrey and Sussex.
CR Aliasgharzadeh A, 2015, BRIT J NUTR, V113, P321, DOI 10.1017/S0007114514003675
   Alles MS, 1999, AM J CLIN NUTR, V69, P980
   Alles MS, 1999, AM J CLIN NUTR, V69, P64
   Bodinham CL, 2014, ENDOCR CONNECT, V3, P75, DOI 10.1530/EC-14-0036
   Bodinham CL, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0040834
   Byrne CS, 2015, INT J OBESITY, V39, P1331, DOI 10.1038/ijo.2015.84
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   Caporaso JG, 2010, NAT METHODS, V7, P335, DOI 10.1038/nmeth.f.303
   Catry E, 2015, LIFE SCI, V132, P77, DOI 10.1016/j.lfs.2015.04.004
   Creely SJ, 2007, AM J PHYSIOL-ENDOC M, V292, pE740, DOI 10.1152/ajpendo.00302.2006
   Davis LMG, 2010, INT J FOOD MICROBIOL, V144, P285, DOI 10.1016/j.ijfoodmicro.2010.10.007
   Davis LMG, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0025200
   Dehghan P, 2016, COMPLEMENT THER MED, V24, P96, DOI 10.1016/j.ctim.2015.12.010
   Ellis RJ, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0054783
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   Gargari BP, 2015, COMPLEMENT THER MED, V23, P810, DOI 10.1016/j.ctim.2015.09.005
   Gargari BP, 2013, DIABETES METAB J, V37, P140, DOI 10.4093/dmj.2013.37.2.140
   Ghoshal S, 2009, J LIPID RES, V50, P90, DOI 10.1194/jlr.M800156-JLR200
   Horton F, 2014, DIABETIC MED, V31, P559, DOI 10.1111/dme.12360
   Johnston KL, 2010, DIABETIC MED, V27, P391, DOI 10.1111/j.1464-5491.2010.02923.x
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kettle H, 2015, ENVIRON MICROBIOL, V17, P1615, DOI 10.1111/1462-2920.12599
   Lambeth Stacey M, 2015, J Diabetes Obes, V2, P1
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Luo J, 2000, J NUTR, V130, P1572, DOI 10.1093/jn/130.6.1572
   Mithieux G, 2006, BIOCHEM PHARMACOL, V72, P1756, DOI 10.1016/j.bcp.2006.10.029
   Moreno-Navarrete JM, 2012, INT J OBESITY, V36, P1442, DOI 10.1038/ijo.2011.256
   Napolitano A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100778
   Pussinen PJ, 2011, DIABETES CARE, V34, P392, DOI 10.2337/dc10-1676
   Quince C, 2011, BMC BIOINFORMATICS, V12, DOI 10.1186/1471-2105-12-38
   Quince C, 2009, NAT METHODS, V6, P639, DOI [10.1038/NMETH.1361, 10.1038/nmeth.1361]
   Raso GM, 2014, J NUTR BIOCHEM, V25, P81, DOI 10.1016/j.jnutbio.2013.09.006
   Remely M, 2014, BENEF MICROBES, V5, P33, DOI 10.3920/BM2013.006
   Sato J, 2014, DIABETES CARE, V37, P2343, DOI 10.2337/dc13-2817
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Teshima Christopher W, 2008, Curr Gastroenterol Rep, V10, P443, DOI 10.1007/s11894-008-0083-y
   Vulevic J, 2015, BRIT J NUTR, V114, P586, DOI 10.1017/S0007114515001889
   Walker AW, 2013, PHARMACOL RES, V69, P75, DOI 10.1016/j.phrs.2012.09.008
   Walton GE, 2012, BRIT J NUTR, V107, P1466, DOI 10.1017/S0007114511004697
   Wang Q, 2007, APPL ENVIRON MICROB, V73, P5261, DOI 10.1128/AEM.00062-07
   Wang ZT, 2006, J TRAUMA, V61, P650, DOI 10.1097/01.ta.0000196574.70614.27
   Wu XK, 2010, CURR MICROBIOL, V61, P69, DOI 10.1007/s00284-010-9582-9
   YAMASHITA K, 1984, NUTR RES, V4, P961, DOI 10.1016/S0271-5317(84)80075-5
NR 47
TC 75
Z9 77
U1 2
U2 51
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD DEC
PY 2016
VL 116
IS 11
BP 1869
EP 1877
DI 10.1017/S0007114516004086
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA EI7ZX
UT WOS:000392724800003
PM 27974055
OA Green Accepted, Bronze, Green Published
DA 2023-06-08
ER

PT J
AU Gu, CY
   Yang, Y
   Xiang, H
   Li, S
   Liang, LN
   Sui, H
   Zhan, LB
   Lu, XG
AF Gu, Chunyan
   Yang, Ye
   Xiang, Hong
   Li, Shu
   Liang, Lina
   Sui, Hua
   Zhan, Libin
   Lu, Xiaoguang
TI Deciphering bacterial community changes in zucker diabetic fatty rats
   based on 16S rRNA gene sequences analysis
SO ONCOTARGET
LA English
DT Article
DE type 2 diabetes; zucker diabetic fatty rat; gastrointestinal microbe;
   16S rRNA; microbial communities; Pathology Section
ID HUMAN GUT MICROBIOTA; DIET-INDUCED OBESITY; LEPTIN RECEPTOR;
   BIFIDOBACTERIUM-ANIMALIS; WEIGHT-GAIN; DISEASE; HEALTH; MICE;
   RESISTANCE; METFORMIN
AB The aim of the present pilot study was deciphering bacterial community changes in Zucker diabetic fatty rats (ZDF rats), a model of type 2 diabetes. Recent studies unmasked that the status of gastrointestinal tract microbiota has a marked impact on nutrition-related syndromes such as obesity and type-2 diabetes (T2D). In this study, samples taken from the gastrointestinal tracts (GI tracts) of ZDF and their lean littermates (ZL rats) were subjected to 16S rRNA gene sequence-based analysis to examine the characteristic bacterial communities, including those located in the stomach, duodenum, jejunum, ileum, cecum and feces. Results revealed that the Firmicutes/Bacteroidetes ratio was increased and greater numbers of Lactobacillus were detected along GI tracts in ZDF rats compared to ZL rats. In conclusion, this work is the first study to systematically characterize bacterial communities along ZDF rat GI tract and provides substantial evidence supporting a prospective strategy to alter the GI microbial communities improving obesity and T2D.
C1 [Gu, Chunyan; Yang, Ye; Zhan, Libin] Nanjing Univ Chinese Med, Basic Med Coll, Nanjing, Jiangsu, Peoples R China.
   [Xiang, Hong; Li, Shu; Zhan, Libin] Dalian Med Univ, Affiliated Hosp 2, Dalian, Liaoning, Peoples R China.
   [Lu, Xiaoguang] Dalian Univ, Zhongshan Hosp, Dept Emergency Med, Dalian, Liaoning, Peoples R China.
   [Liang, Lina; Sui, Hua] Dalian Med Univ, Inst Integrat Med, Dalian, Liaoning, Peoples R China.
C3 Nanjing University of Chinese Medicine; Dalian Medical University;
   Dalian University; Dalian Medical University
RP Zhan, LB (通讯作者)，Nanjing Univ Chinese Med, Basic Med Coll, Nanjing, Jiangsu, Peoples R China.; Zhan, LB (通讯作者)，Dalian Med Univ, Affiliated Hosp 2, Dalian, Liaoning, Peoples R China.; Lu, XG (通讯作者)，Dalian Univ, Zhongshan Hosp, Dept Emergency Med, Dalian, Liaoning, Peoples R China.
EM zlbnj@njucm.edu.cn; dllxg100@126.com
RI yang, yang/GWB-9426-2022; Lang, Ming/HIK-0758-2022; YANG, YE/F-4987-2015
OI YANG, YE/0000-0003-0228-5102
FU National Nature Science Foundation of China [81230084]; Specialized
   Research Fund for the Doctoral Program of Higher Education of China
   [20132105130001]
FX This study was supported by grants from the National Nature Science
   Foundation of China (No. 81230084), by the Specialized Research Fund for
   the Doctoral Program of Higher Education of China (20132105130001).
CR Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   Backhed F, 2004, P NATL ACAD SCI USA, V101, P15718, DOI 10.1073/pnas.0407076101
   Backhed F, 2007, P NATL ACAD SCI USA, V104, P979, DOI 10.1073/pnas.0605374104
   Bakker GJ, 2015, J CLIN GASTROENTEROL, V49, pS13, DOI 10.1097/MCG.0000000000000363
   Candela M, 2016, BRIT J NUTR, P1
   Cani PD, 2007, DIABETOLOGIA, V50, P2374, DOI 10.1007/s00125-007-0791-0
   Caporaso JG, 2010, NAT METHODS, V7, P335, DOI 10.1038/nmeth.f.303
   Caricilli Andrea M, 2016, PLoS Biol, V14, pe1002479, DOI 10.1371/journal.pbio.1002479
   Cho I, 2012, NAT REV GENET, V13, P260, DOI 10.1038/nrg3182
   CONNAUGHTON RM, 2016, THE PROCEEDINGS OF T, V75, P115
   da Silva BA, 1998, ENDOCRINOLOGY, V139, P3681, DOI 10.1210/en.139.9.3681
   de Lemos ET, 2007, MED SCI MONITOR, V13, pBR172
   De Vadder F, 2014, CELL, V156, P84, DOI 10.1016/j.cell.2013.12.016
   Dehkordi Elham Hashemi, 2016, Adv Biomed Res, V5, P88, DOI 10.4103/2277-9175.182219
   DeSantis TZ, 2003, BIOINFORMATICS, V19, P1461, DOI 10.1093/bioinformatics/btg200
   Eckburg PB, 2005, SCIENCE, V308, P1635, DOI 10.1126/science.1110591
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Fugmann M, 2015, SCI REP-UK, V5, DOI 10.1038/srep13212
   Haange SB, 2016, EXPERT REV PROTEOMIC, V13, P535, DOI 10.1080/14789450.2016.1190652
   Ham M, 2016, DIABETES
   Hopkins MJ, 2002, DIGEST LIVER DIS, V34, pS12, DOI 10.1016/S1590-8658(02)80157-8
   Klein MS, 2016, J DIABETES RES, V2016, DOI 10.1155/2016/3898502
   Le Kim-Anne, 2012, Front Physiol, V3, P496, DOI 10.3389/fphys.2012.00496
   Leong A, 2016, DIABETES CARE, V39, P539, DOI 10.2337/dc15-2080
   Ley RE, 2005, P NATL ACAD SCI USA, V102, P11070, DOI 10.1073/pnas.0504978102
   Ley RE, 2006, NATURE, V444, P1022, DOI 10.1038/4441022a
   Mallappa Rashmi H, 2012, Indian J Endocrinol Metab, V16, P20, DOI 10.4103/2230-8210.91178
   Mancuso FP, 2016, FRONT MICROBIOL, V7, DOI 10.3389/fmicb.2016.00476
   Martinerie C, 2016, DIABETES
   Maurice CF, 2013, CELL, V152, P39, DOI 10.1016/j.cell.2012.10.052
   Mendis S, 2015, STROKE, V46, pE121, DOI 10.1161/STROKEAHA.115.008097
   Million M, 2012, INT J OBESITY, V36, P817, DOI 10.1038/ijo.2011.153
   Million M, 2012, MICROB PATHOGENESIS, V53, P100, DOI 10.1016/j.micpath.2012.05.007
   Muegge BD, 2011, SCIENCE, V332, P970, DOI 10.1126/science.1198719
   Musso G, 2010, DIABETES CARE, V33, P2277, DOI 10.2337/dc10-0556
   Ogawa A, 2014, LIPIDS HEALTH DIS, V13, DOI 10.1186/1476-511X-13-36
   Phillips MS, 1996, NAT GENET, V13, P18, DOI 10.1038/ng0596-18
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Qin JJ, 2010, NATURE, V464, P59, DOI 10.1038/nature08821
   Riserus U, 2009, PROG LIPID RES, V48, P44, DOI 10.1016/j.plipres.2008.10.002
   Samuel VT, 2016, J CLIN INVEST, V126, P12, DOI 10.1172/JCI77812
   Savu O, 2016, INT UROL NEPHROL, V48, P265, DOI 10.1007/s11255-015-1175-x
   Schloss PD, 2011, APPL ENVIRON MICROB, V77, P3219, DOI 10.1128/AEM.02810-10
   Schloss PD, 2009, APPL ENVIRON MICROB, V75, P7537, DOI 10.1128/AEM.01541-09
   Stenman LK, 2014, BENEF MICROBES, V5, P437, DOI 10.3920/BM2014.0014
   Sun Q, 2015, INT BIODETER BIODEGR, V104, P224, DOI 10.1016/j.ibiod.2015.06.003
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Turnbaugh PJ, 2009, SCI TRANSL MED, V1, DOI 10.1126/scitranslmed.3000322
   Turnbaugh PJ, 2009, NATURE, V457, P480, DOI 10.1038/nature07540
   Wei ZG, 2015, MOL BIOSYST, V11, P1907, DOI 10.1039/c5mb00089k
   Westcott SL, 2015, PEERJ, V3, DOI 10.7717/peerj.1487
   Xu Y, 2013, JAMA-J AM MED ASSOC, V310, P948, DOI 10.1001/jama.2013.168118
   Yamashita T, 1997, DIABETES, V46, P1077, DOI 10.2337/diabetes.46.6.1077
   Yokoi N, 2013, J DIABETES RES, V2013, DOI 10.1155/2013/103731
   Zeuthen LH, 2006, CLIN VACCINE IMMUNOL, V13, P365, DOI 10.1128/CVI.13.3.365-375.2006
   Zhang HS, 2009, P NATL ACAD SCI USA, V106, P2365, DOI 10.1073/pnas.0812600106
   Zhang X, 2015, SCI REP-UK, V5, DOI 10.1038/srep14405
   Zlobine I, 2016, BIOCH BIOPHYSICA ACT
NR 58
TC 16
Z9 17
U1 2
U2 14
PU IMPACT JOURNALS LLC
PI ORCHARD PARK
PA 6666 E QUAKER ST, STE 1, ORCHARD PARK, NY 14127 USA
EI 1949-2553
J9 ONCOTARGET
JI Oncotarget
PD AUG 2
PY 2016
VL 7
IS 31
BP 48941
EP 48952
DI 10.18632/oncotarget.10597
PG 12
WC Oncology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Cell Biology
GA DY8ZS
UT WOS:000385422000011
PM 27418144
OA Green Published, gold, Green Submitted
DA 2023-06-08
ER

PT J
AU Zimmermann, M
   Patil, KR
   Typas, A
   Maier, L
AF Zimmermann, Michael
   Patil, Kiran Raosaheb
   Typas, Athanasios
   Maier, Lisa
TI Towards a mechanistic understanding of reciprocal drug-microbiome
   interactions
SO MOLECULAR SYSTEMS BIOLOGY
LA English
DT Review
DE antibiotics; antimicrobials; human gut microbiome; metagenomics;
   microbial community
ID HUMAN GUT MICROBIOME; INTESTINAL MICROBIOTA; GERM-FREE;
   DROSOPHILA-MELANOGASTER; BACTERIAL METABOLISM; METFORMIN ALTERS; C.
   ELEGANS; IN-VITRO; 1ST YEAR; HOST
AB Broad-spectrum antibiotics target multiple gram-positive and gram-negative bacteria, and can collaterally damage the gut microbiota. Yet, our knowledge of the extent of damage, the antibiotic activity spectra, and the resistance mechanisms of gut microbes is sparse. This limits our ability to mitigate microbiome-facilitated spread of antibiotic resistance. In addition to antibiotics, non-antibiotic drugs affect the human microbiome, as shown by metagenomics as well as in vitro studies. Microbiome-drug interactions are bidirectional, as microbes can also modulate drugs. Chemical modifications of antibiotics mostly function as antimicrobial resistance mechanisms, while metabolism of non-antibiotics can also change the drugs' pharmacodynamic, pharmacokinetic, and toxic properties. Recent studies have started to unravel the extensive capacity of gut microbes to metabolize drugs, the mechanisms, and the relevance of such events for drug treatment. These findings raise the question whether and to which degree these reciprocal drug-microbiome interactions will differ across individuals, and how to take them into account in drug discovery and precision medicine. This review describes recent developments in the field and discusses future study areas that will benefit from systems biology approaches to better understand the mechanistic role of the human gut microbiota in drug actions.
C1 [Zimmermann, Michael; Patil, Kiran Raosaheb; Typas, Athanasios] European Mol Biol Lab, Struct & Computat Biol Unit, Heidelberg, Germany.
   [Patil, Kiran Raosaheb] Univ Cambridge, MRC, Toxicol Unit, Cambridge, England.
   [Typas, Athanasios] European Mol Biol Lab, Genome Biol Unit, Heidelberg, Germany.
   [Maier, Lisa] Univ Tubingen, Interfac Inst Microbiol & Infect Med, Tubingen, Germany.
   [Maier, Lisa] Univ Tubingen, Cluster Excellence Controlling Microbes Fight Inf, Tubingen, Germany.
C3 European Molecular Biology Laboratory (EMBL); University of Cambridge;
   European Molecular Biology Laboratory (EMBL); Eberhard Karls University
   of Tubingen; Eberhard Karls University of Tubingen
RP Zimmermann, M (通讯作者)，European Mol Biol Lab, Struct & Computat Biol Unit, Heidelberg, Germany.; Maier, L (通讯作者)，Univ Tubingen, Interfac Inst Microbiol & Infect Med, Tubingen, Germany.; Maier, L (通讯作者)，Univ Tubingen, Cluster Excellence Controlling Microbes Fight Inf, Tubingen, Germany.
EM michael.zimmermann@embl.de; l.maier@uni-tuebingen.de
RI Maier, Lisa/ABH-1893-2021; Patil, Kiran Raosaheb/B-9709-2009
OI Maier, Lisa/0000-0002-6473-4762; Zimmermann,
   Michael/0000-0002-5797-3589; Typas, Athanasios/0000-0002-0797-9018;
   Patil, Kiran Raosaheb/0000-0002-6166-8640
FU German Research Foundation (Emmy-Noether Program, CMFI Cluster of
   Excellence) [EXE 2124]; ERC CoG uCARE; UK Medical Research Council
   [MC_UU_00025/11]; Daimler-und-Benz-Stiftung; MRC [MC_UU_00025/11]
   Funding Source: UKRI
FX The authors acknowledge funding from the German Research Foundation
   (Emmy-Noether Program, CMFI Cluster of Excellence (EXE 2124)) to L.M.,
   from ERC CoG uCARE to A.T., from UK Medical Research Council (project
   no. MC_UU_00025/11) to K.R.P., and from the Daimler-und-Benz-Stiftung to
   M. Z.
CR Almeida A, 2019, NATURE, V568, P499, DOI 10.1038/s41586-019-0965-1
   Aranda-Diaz A, 2020, ELIFE, V9, DOI 10.7554/eLife.51493
   Backhed F, 2015, CELL HOST MICROBE, V17, P690, DOI [10.1016/j.chom.2015.04.004, 10.1016/j.chom.2015.05.012]
   Bauer PV, 2018, CELL METAB, V27, P101, DOI 10.1016/j.cmet.2017.09.019
   Baym M, 2016, SCIENCE, V351, DOI 10.1126/science.aad3292
   Bhatt AP, 2020, P NATL ACAD SCI USA, V117, P7374, DOI 10.1073/pnas.1918095117
   Bolan S, 2016, EMBO REP, V17, P929, DOI 10.15252/embr.201642572
   Cabral DJ, 2019, CELL METAB, V30, P800, DOI 10.1016/j.cmet.2019.08.020
   Cabreiro F, 2013, CELL, V153, P228, DOI 10.1016/j.cell.2013.02.035
   Cacace Elisabetta, 2017, Curr Opin Syst Biol, V4, P35, DOI 10.1016/j.coisb.2017.05.020
   Cammarota G, 2019, GUT, V68, P2111, DOI 10.1136/gutjnl-2019-319548
   Chen HW, 2019, CELL, V177, P1217, DOI 10.1016/j.cell.2019.03.036
   Chen PB, 2020, NAT BIOTECHNOL, V38, P1288, DOI 10.1038/s41587-020-0549-5
   Cho I, 2012, NATURE, V488, P621, DOI 10.1038/nature11400
   Clayton TA, 2009, P NATL ACAD SCI USA, V106, P14728, DOI 10.1073/pnas.0904489106
   Cohen LJ, 2017, NATURE, V549, P48, DOI 10.1038/nature23874
   Colosimo DA, 2019, CELL HOST MICROBE, V26, P273, DOI 10.1016/j.chom.2019.07.002
   Cox LM, 2014, CELL, V158, P705, DOI 10.1016/j.cell.2014.05.052
   Coyne MJ, 2014, MBIO, V5, DOI 10.1128/mBio.01305-14
   DeFilipp Z, 2019, NEW ENGL J MED, V381, P2043, DOI 10.1056/NEJMoa1910437
   Dempsey Joseph L, 2019, Curr Pharmacol Rep, V5, P481, DOI 10.1007/s40495-019-00200-w
   Djoumbou-Feunang Y, 2019, J CHEMINFORMATICS, V11, DOI 10.1186/s13321-018-0324-5
   Douglas Angela E, 2018, Drug Discov Today Dis Models, V28, P43, DOI 10.1016/j.ddmod.2019.08.004
   Douglas AE, 2019, NAT REV MICROBIOL, V17, P764, DOI 10.1038/s41579-019-0242-1
   ELMER GW, 1984, XENOBIOTICA, V14, P829, DOI 10.3109/00498258409151481
   Eribol P, 2016, BIOMICROFLUIDICS, V10, DOI 10.1063/1.4940886
   Estrela AB, 2019, MBIO, V10, DOI 10.1128/mBio.02587-19
   Falony G, 2016, SCIENCE, V352, P560, DOI 10.1126/science.aad3503
   Fernandez-Hernandez I, 2016, EMBO REP, V17, P471, DOI 10.15252/embr.201642080
   Fong WN, 2020, ONCOGENE, V39, P4925, DOI 10.1038/s41388-020-1341-1
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Forster SC, 2019, NAT BIOTECHNOL, V37, P186, DOI 10.1038/s41587-018-0009-7
   Franzosa EA, 2015, P NATL ACAD SCI USA, V112, pE2930, DOI 10.1073/pnas.1423854112
   Frohlich EE, 2016, BRAIN BEHAV IMMUN, V56, P140, DOI 10.1016/j.bbi.2016.02.020
   Fu ZDDN, 2017, DRUG METAB DISPOS, V45, P1225, DOI 10.1124/dmd.117.077313
   Fuller AT, 1937, LANCET, V1, P194
   Garcia-Gonzalez AP., 2018, DRUG DISCOV TODAY DI, V28, P21, DOI [10.1016/j.ddmod.2019.08.001, DOI 10.1016/J.DDMOD.2019.08.001]
   Garcia-Gonzalez AP, 2017, CELL, V169, P431, DOI 10.1016/j.cell.2017.03.046
   Garland M, 2020, CELL REP MED, V1, DOI 10.1016/j.xcrm.2020.100005
   Gil-Cruz C, 2019, SCIENCE, V366, P881, DOI 10.1126/science.aav3487
   Giles EM, 2019, NAT REV MICROBIOL, V17, P719, DOI 10.1038/s41579-019-0271-9
   Goodman AL, 2011, P NATL ACAD SCI USA, V108, P6252, DOI 10.1073/pnas.1102938108
   Gurbatri CR, 2020, SCI TRANSL MED, V12, DOI 10.1126/scitranslmed.aax0876
   Guthrie L, 2019, ELIFE, V8, DOI 10.7554/eLife.42866
   Guzman-Rodriguez M, 2018, METHODS, V149, P31, DOI 10.1016/j.ymeth.2018.08.003
   Hagan T, 2019, CELL, V178, P1313, DOI 10.1016/j.cell.2019.08.010
   Haiser HJ, 2013, SCIENCE, V341, P295, DOI 10.1126/science.1235872
   Hwang I, 2015, FASEB J, V29, P2397, DOI 10.1096/fj.14-265983
   Imhann F, 2016, GUT, V65, P740, DOI 10.1136/gutjnl-2015-310376
   Ishizaki J, 2012, BIOL PHARM BULL, V35, P1009, DOI 10.1248/bpb.b110639
   Jackson MA, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-018-05184-7
   Jalili-Firoozinezhad S, 2019, NAT BIOMED ENG, V3, P520, DOI 10.1038/s41551-019-0397-0
   Jariwala PB, 2020, ACS CHEM BIOL, V15, P217, DOI 10.1021/acschembio.9b00788
   Javdan B, 2020, CELL, V181, P1661, DOI 10.1016/j.cell.2020.05.001
   Kintses B, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-13618-z
   Kirchmair J, 2015, NAT REV DRUG DISCOV, V14, P387, DOI 10.1038/nrd4581
   Klunemann M, 2014, TRENDS BIOTECHNOL, V32, P157, DOI 10.1016/j.tibtech.2014.01.005
   Koh A, 2020, MOL CELL, V78, P584, DOI 10.1016/j.molcel.2020.03.005
   Koppel N, 2018, ELIFE, V7, DOI [10.7554/eLife.33953, 10.7554/elife.33953]
   Kops CD, 2019, FRONT CHEM, V7, DOI 10.3389/fchem.2019.00402
   Kuhn M, 2016, NUCLEIC ACIDS RES, V44, pD1075, DOI 10.1093/nar/gkv1075
   Kummen M, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-62261-y
   Kuno T, 2019, DRUG METAB PHARMACOK, V34, P159, DOI 10.1016/j.dmpk.2019.01.001
   Kuno T, 2016, MOL PHARMACEUT, V13, P2691, DOI 10.1021/acs.molpharmaceut.6b00259
   Le Bastard Q, 2018, ALIMENT PHARM THER, V47, P332, DOI 10.1111/apt.14451
   Li LY, 2020, MICROBIOME, V8, DOI 10.1186/s40168-020-00806-z
   Li LY, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-12087-8
   LINDENBAUM J, 1981, NEW ENGL J MED, V305, P789, DOI 10.1056/NEJM198110013051403
   Liu SR, 2016, CELL HOST MICROBE, V19, P32, DOI 10.1016/j.chom.2015.12.005
   Lukovac S, 2014, MBIO, V5, DOI 10.1128/mBio.01438-14
   Lynn MA, 2018, CELL HOST MICROBE, V23, P653, DOI 10.1016/j.chom.2018.04.009
   Mager LF, 2020, SCIENCE, V369, P1481, DOI 10.1126/science.abc3421
   Maier L., 2020, GUT, DOI [10.1101/2020.01.09.893560, DOI 10.1101/2020.01.09.893560V1]
   Maier L, 2018, NATURE, V555, P623, DOI 10.1038/nature25979
   Maier L, 2017, CURR OPIN MICROBIOL, V39, P128, DOI 10.1016/j.mib.2017.11.001
   Malfatti MA, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-60982-8
   Mallory EK, 2018, BIOCOMPUT-PAC SYM, P56
   Mateus A, 2020, MOL SYST BIOL, V16, DOI 10.15252/msb.20199232
   Maurice CF, 2013, CELL, V152, P39, DOI 10.1016/j.cell.2012.10.052
   Mehta RS, 2018, NAT MICROBIOL, V3, P347, DOI 10.1038/s41564-017-0096-0
   Mills RH, 2020, GENOME RES, V30, P276, DOI 10.1101/gr.256875.119
   Naito T, 2017, MBIO, V8, DOI 10.1128/mBio.01680-17
   Nakayama H, 1997, PHARMACOGENETICS, V7, P35, DOI 10.1097/00008571-199702000-00005
   Napolitano A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100778
   Nayfach S, 2019, NATURE, V568, P505, DOI 10.1038/s41586-019-1058-x
   Ng KM, 2019, CELL HOST MICROBE, V26, P650, DOI 10.1016/j.chom.2019.10.011
   Nigro G, 2014, CELL HOST MICROBE, V15, P792, DOI 10.1016/j.chom.2014.05.003
   Nobel YR, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms8486
   Norvaisas Povilas, 2018, Current Opinion in Systems Biology, V10, P34, DOI 10.1016/j.coisb.2018.05.006
   O'Reilly LP, 2014, ADV DRUG DELIVER REV, V69, P247, DOI 10.1016/j.addr.2013.12.001
   O'Toole PW, 2017, NAT MICROBIOL, V2, DOI 10.1038/nmicrobiol.2017.57
   Pal C, 2015, TRENDS MICROBIOL, V23, P401, DOI 10.1016/j.tim.2015.02.009
   Palleja A, 2018, NAT MICROBIOL, V3, P1255, DOI 10.1038/s41564-018-0257-9
   Pandey UB, 2011, PHARMACOL REV, V63, P411, DOI 10.1124/pr.110.003293
   Park J, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0156334
   Pasolli E, 2019, CELL, V176, P649, DOI 10.1016/j.cell.2019.01.001
   Pearce SC, 2018, BMC BIOL, V16, DOI 10.1186/s12915-018-0481-z
   PEPPERCORN MA, 1972, J PHARMACOL EXP THER, V181, P555
   Pleguezuelos-Manzano C, 2020, NATURE, V580, P269, DOI 10.1038/s41586-020-2080-8
   Pollet RM, 2017, STRUCTURE, V25, P967, DOI 10.1016/j.str.2017.05.003
   Poyet M, 2019, NAT MED, V25, P1442, DOI 10.1038/s41591-019-0559-3
   Proctor LM, 2019, NATURE, V569, P641, DOI 10.1038/s41586-019-1238-8
   Pryor R, 2019, CELL, V178, P1299, DOI 10.1016/j.cell.2019.08.003
   Pryor R, 2020, ANNU REV PHARMACOL, V60, P417, DOI 10.1146/annurev-pharmtox-010919-023612
   Rashid MU, 2015, CLIN INFECT DIS, V60, pS77, DOI 10.1093/cid/civ137
   Rask-Andersen M, 2011, NAT REV DRUG DISCOV, V10, P579, DOI 10.1038/nrd3478
   Ratzke C, 2018, PLOS BIOL, V16, DOI 10.1371/journal.pbio.2004248
   Rekdal VM, 2019, SCIENCE, V364, P1055, DOI 10.1126/science.aau6323
   Roemhild R, 2020, PLOS BIOL, V18, DOI 10.1371/journal.pbio.3000612
   Rothschild D, 2018, NATURE, V555, P210, DOI 10.1038/nature25973
   Ruiz VE, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-00531-6
   Sato T, 2009, NATURE, V459, P262, DOI 10.1038/nature07935
   Sausset R, 2020, MUCOSAL IMMUNOL, V13, P205, DOI 10.1038/s41385-019-0250-5
   Schopper S, 2017, NAT PROTOC, V12, P2391, DOI 10.1038/nprot.2017.100
   Scott TA, 2017, CELL, V169, P442, DOI 10.1016/j.cell.2017.03.040
   Selwyn FP, 2016, DRUG METAB DISPOS, V44, P262, DOI 10.1124/dmd.115.067504
   Shetty SA, 2019, CURR OPIN BIOTECH, V58, P146, DOI 10.1016/j.copbio.2019.03.009
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Sivan A, 2015, SCIENCE, V350, P1084, DOI 10.1126/science.aac4255
   Sommer F, 2017, NAT REV MICROBIOL, V15, P630, DOI 10.1038/nrmicro.2017.58
   Sousa T, 2014, J PHARM SCI-US, V103, P3171, DOI 10.1002/jps.24103
   Spanogiannopoulos P., 2019, DRUG RESISTANT GUT B, DOI [10.1101/820084, DOI 10.1101/820084]
   Suez J, 2019, NAT MED, V25, P716, DOI 10.1038/s41591-019-0439-x
   Suez J, 2018, CELL, V174, P1406, DOI 10.1016/j.cell.2018.08.047
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Tanoue T, 2019, NATURE, V565, P600, DOI 10.1038/s41586-019-0878-z
   Taur Y, 2018, SCI TRANSL MED, V10, DOI 10.1126/scitranslmed.aap9489
   Taylor MR, 2019, SCI ADV, V5, DOI 10.1126/sciadv.aax2358
   Nguyen TLA, 2015, DIS MODEL MECH, V8, P1, DOI 10.1242/dmm.017400
   Ticinesi A, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-10734-y
   Tramontano M, 2018, NAT MICROBIOL, V3, P514, DOI 10.1038/s41564-018-0123-9
   Trinder M, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.00751
   Uchimura Y, 2018, IMMUNITY, V49, P545, DOI 10.1016/j.immuni.2018.08.004
   Underhill GH, 2018, DRUG METAB DISPOS, V46, P1626, DOI 10.1124/dmd.118.083295
   van de Steeg E, 2018, DRUG METAB DISPOS, V46, P1596, DOI 10.1124/dmd.118.081026
   Vega NM, 2014, CURR OPIN MICROBIOL, V21, P28, DOI 10.1016/j.mib.2014.09.003
   Venturelli OS, 2018, MOL SYST BIOL, V14, DOI 10.15252/msb.20178157
   Vetizou M, 2015, SCIENCE, V350, P1079, DOI 10.1126/science.aad1329
   Viaud S, 2013, SCIENCE, V342, P971, DOI 10.1126/science.1240537
   Vieira-Silva S, 2020, NATURE, V581, P310, DOI 10.1038/s41586-020-2269-x
   Vila AV, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-019-14177-z
   Wallace BD, 2010, SCIENCE, V330, P831, DOI 10.1126/science.1191175
   Walter J, 2020, CELL, V180, P221, DOI 10.1016/j.cell.2019.12.025
   Wampach L, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.00738
   Wegh CAM, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20194673
   Williamson B, 2017, J PHARMACOL TOX MET, V84, P31, DOI 10.1016/j.vascn.2016.10.006
   Willing BP, 2011, NAT REV MICROBIOL, V9, P233, DOI 10.1038/nrmicro2536
   Wilson ID, 2017, TRANSL RES, V179, P204, DOI 10.1016/j.trsl.2016.08.002
   Wlodarska M, 2017, CELL HOST MICROBE, V22, P25, DOI 10.1016/j.chom.2017.06.007
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Yin XL, 2014, NAT METHODS, V11, P106, DOI 10.1038/nmeth.2737
   Zampieri M, 2018, SCI TRANSL MED, V10, DOI 10.1126/scitranslmed.aal3973
   Zheng DW, 2019, NAT BIOMED ENG, V3, P717, DOI 10.1038/s41551-019-0423-2
   Zimmermann J, 2020, ISME J, V14, P26, DOI 10.1038/s41396-019-0504-y
   Zimmermann M, 2019, NATURE, V570, P462, DOI 10.1038/s41586-019-1291-3
   Zimmermann M, 2019, SCIENCE, V363, P600, DOI 10.1126/science.aat9931
   Zimmermann-Kogadeeva M, 2020, GUT MICROBES, V11, P587, DOI 10.1080/19490976.2019.1667724
   Zitvogel L, 2018, SCIENCE, V359, P1366, DOI 10.1126/science.aar6918
   Zmora N, 2018, CELL, V174, P1388, DOI 10.1016/j.cell.2018.08.041
   Zou YQ, 2019, NAT BIOTECHNOL, V37, P179, DOI 10.1038/s41587-018-0008-8
NR 160
TC 28
Z9 31
U1 6
U2 33
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1744-4292
J9 MOL SYST BIOL
JI Mol. Syst. Biol.
PD MAR
PY 2021
VL 17
IS 3
AR e10116
DI 10.15252/msb.202010116
PG 15
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA RH6TL
UT WOS:000636348400008
PM 33734582
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Zhang, L
   Luo, J
   Li, XQ
   Guo, SJ
   Shi, DY
AF Zhang, Liang
   Luo, Jiao
   Li, Xiangqian
   Guo, Shuju
   Shi, Dayong
TI 16S rRNA Sequencing and Metagenomics Study of Gut Microbiota:
   Implications of BDB on Type 2 Diabetes Mellitus
SO MARINE DRUGS
LA English
DT Article
DE BDB; marine red alga; type 2 diabetes mellitus; gut microbiota; 16S rRNA
   sequencing; metagenomics
ID CHAIN FATTY-ACIDS; AKKERMANSIA-MUCINIPHILA; RHODOMELA-CONFERVOIDES;
   BROMOPHENOLS; METFORMIN; ALTERS; TARGET; FUTURE
AB Gut microbiota has a critical role in metabolic diseases, including type 2 diabetes mellitus (T2DM). 3-bromo-4,5-bis(2,3-dibromo-4,5-dihydroxybenzyl)-1,2-benzenediol (BDB) is a natural bromophenol isolated from marine red alga Rhodomela confervoides. Our latest research showed that BDB could alleviate T2DM in diabetic BKS db mice. To find out whether BDB modulates the composition of the gut microbiota during T2DM treatment, 24 BKS db diabetic mice were randomly grouped to receive BDB (n = 6), metformin (n = 6), or the vehicle (n = 6) for 7 weeks in a blinded manner. Non-diabetic BKS mice (n = 6) were used as normal control. Diabetic mice treated with BDB or metformin demonstrated significant reductions in fasting blood glucose (FBG) levels compared with the vehicle-treated mice in the 7th week. Pyrosequencing of the V3-V4 regions of the 16S rRNA gene revealed the changes of gut microbiota in response to BDB treatment. The result demonstrated short-chain acid (SCFA) producing bacteria Lachnospiraceae and Bacteroides were found to be significantly more abundant in the BDB and metformin treated group than the vehicle-treatment diabetic group. Remarkably, at the genus levels, Akkermansia elevated significantly in the BDB-treatment group. Metagenomic results indicated that BDB may alleviate the metabolic disorder of diabetic mice by promoting propanoate metabolism and inhibiting starch and sucrose metabolism, amino sugar and nucleotide sugar metabolism. In conclusion, our study suggests that the anti-diabetic effect of BDB is closely related to the modulating structure of gut microbiota and the improvement of functional metabolism genes of intestinal microorganisms.
C1 [Zhang, Liang; Guo, Shuju] Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, 7 Nanhai Rd, Qingdao 266071, Peoples R China.
   [Zhang, Liang; Guo, Shuju] Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod Qingdao, Qingdao 266000, Peoples R China.
   [Zhang, Liang; Guo, Shuju] Univ Chinese Acad Sci, Sch Earth & Planetary, Beijing 100049, Peoples R China.
   [Luo, Jiao] Qingdao Univ, Sch Publ Hlth, Qingdao 266071, Peoples R China.
   [Li, Xiangqian; Shi, Dayong] Shandong Univ, State Key Lab Microbial Technol, 72 Binhai Rd, Qingdao 266237, Peoples R China.
C3 Chinese Academy of Sciences; Institute of Oceanology, CAS; Laoshan
   Laboratory; Chinese Academy of Sciences; University of Chinese Academy
   of Sciences, CAS; Qingdao University; Shandong University
RP Guo, SJ (通讯作者)，Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, 7 Nanhai Rd, Qingdao 266071, Peoples R China.; Guo, SJ (通讯作者)，Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod Qingdao, Qingdao 266000, Peoples R China.; Guo, SJ (通讯作者)，Univ Chinese Acad Sci, Sch Earth & Planetary, Beijing 100049, Peoples R China.; Shi, DY (通讯作者)，Shandong Univ, State Key Lab Microbial Technol, 72 Binhai Rd, Qingdao 266237, Peoples R China.
EM z11172627930@163.com; luojiao2012@163.com; lixiangqian@sdu.edu.cn;
   guoshuju@qdio.ac.cn; shidayong@sdu.edu.cn
RI Guo, shuju/IAR-3466-2023
FU National Natural Science Foundation of China [817033540, 81803344];
   Shandong Provincial Natural Science Foundation for Distinguished Young
   Scholars [JQ201722]; Taishan scholar Youth Project of Shandong province;
   Qingdao Marine Biomedical Science and Technology Innovation Center
   Project [2017-CXZX01-1-1, 2017-CXZX01-3-9]; NSFC-Shan-dong Joint Fund
   [U1706213]; National Program for Support of Top-notch Young
   Professionals; Key research and development plan (soft science) project
   of Shandong province [2019RKE27018]
FX This work was supported by the National Natural Science Foundation of
   China (817033540, 81803344), Shandong Provincial Natural Science
   Foundation for Distinguished Young Scholars (JQ201722), Taishan scholar
   Youth Project of Shandong province, Qingdao Marine Biomedical Science
   and Technology Innovation Center Project (2017-CXZX01-1-1,
   2017-CXZX01-3-9), NSFC-Shan-dong Joint Fund (U1706213), National Program
   for Support of Top-notch Young Professionals, Key research and
   development plan (soft science) project of Shandong province
   (2019RKE27018).
CR Brunkwall L, 2017, DIABETOLOGIA, V60, P943, DOI 10.1007/s00125-017-4278-3
   Chatterjee S, 2017, LANCET, V389, P2239, DOI 10.1016/S0140-6736(17)30058-2
   De Vadder F, 2016, CELL METAB, V24, P151, DOI 10.1016/j.cmet.2016.06.013
   Derrien M, 2004, INT J SYST EVOL MICR, V54, P1469, DOI 10.1099/ijs.0.02873-0
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Farzaei MH, 2015, INT J PHARMACOL, V11, P874, DOI 10.3923/ijp.2015.874.887
   Frkic RL, 2017, J MED CHEM, V60, P4584, DOI 10.1021/acs.jmedchem.6b01727
   Han JL, 2014, WORLD J GASTROENTERO, V20, P17737, DOI 10.3748/wjg.v20.i47.17737
   Jia LL, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-07335-0
   Kang S, 2010, INFLAMM BOWEL DIS, V16, P2034, DOI 10.1002/ibd.21319
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kim CH, 2018, CELL MOL IMMUNOL, V15, P88, DOI 10.1038/cmi.2017.57
   Kimura I, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms2852
   Koh A, 2016, CELL, V165, P1332, DOI 10.1016/j.cell.2016.05.041
   Kurokawa K, 2007, DNA RES, V14, P169, DOI 10.1093/dnares/dsm018
   Larsen PE, 2015, GIGASCIENCE, V4, DOI 10.1186/s13742-015-0084-3
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Lei L, 2015, METABOLISM, V64, P1250, DOI 10.1016/j.metabol.2015.06.014
   Ley RE, 2005, P NATL ACAD SCI USA, V102, P11070, DOI 10.1073/pnas.0504978102
   Ley RE, 2006, NATURE, V444, P1022, DOI 10.1038/4441022a
   Li K, 2012, FOOD CHEM, V135, P868, DOI 10.1016/j.foodchem.2012.05.117
   Li M, 2016, J TRANSL MED, V14, DOI 10.1186/s12967-016-0987-5
   Luo J, 2020, BRIT J PHARMACOL, V177, P4464, DOI 10.1111/bph.15195
   Ma RCW, 2014, LANCET DIABETES ENDO, V2, P980, DOI 10.1016/S2213-8587(14)70145-7
   Park DY, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0059470
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Qin N, 2014, NATURE, V513, P59, DOI 10.1038/nature13568
   Shi DY, 2008, CHINESE SCI BULL, V53, P2476, DOI 10.1007/s11434-008-0353-y
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Tilg H, 2014, GUT, V63, P1513, DOI 10.1136/gutjnl-2014-306928
   Tseng CK, 2004, HYDROBIOLOGIA, V512, P11, DOI 10.1023/B:HYDR.0000020363.37807.ec
   Wang L, 2016, SCI REP-UK, V6, DOI [10.1038/srep38380, 10.1038/srep33251, 10.1038/srep20004]
   Wong JMW, 2006, J CLIN GASTROENTEROL, V40, P235, DOI 10.1097/00004836-200603000-00015
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Xu Y, 2013, JAMA-J AM MED ASSOC, V310, P948, DOI 10.1001/jama.2013.168118
   Yan XF, 2016, J DIABETES RES, V2016, DOI 10.1155/2016/2093171
   Zhang Q, 2018, PEERJ, V6, DOI 10.7717/peerj.4446
   Zhang X, 2012, PLOS ONE, V7, DOI [10.1371/journal.pone.0040320, 10.1371/journal.pone.0042529]
   Zhang X, 2015, SCI REP-UK, V5, DOI 10.1038/srep14405
   Zhao JL, 2004, J NAT PROD, V67, P1032, DOI 10.1021/np030546+
   Zoetendal EG, 2008, GUT, V57, P1605, DOI 10.1136/gut.2007.133603
NR 41
TC 4
Z9 4
U1 0
U2 25
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-3397
J9 MAR DRUGS
JI Mar. Drugs
PD SEP
PY 2020
VL 18
IS 9
AR 469
DI 10.3390/md18090469
PG 17
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA OF5LP
UT WOS:000581249300001
PM 32957565
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Sobhonslidsuk, A
   Chanprasertyothin, S
   Pongrujikorn, T
   Kaewduang, P
   Promson, K
   Petraksa, S
   Ongphiphadhanakul, B
AF Sobhonslidsuk, Abhasnee
   Chanprasertyothin, Suwannee
   Pongrujikorn, Tanjitti
   Kaewduang, Piyaporn
   Promson, Kwannapa
   Petraksa, Supanna
   Ongphiphadhanakul, Boonsong
TI The Association of Gut Microbiota with Nonalcoholic Steatohepatitis in
   Thais
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Article
ID FATTY LIVER-DISEASE; OBESE; EPIDEMIOLOGY; PATHOGENESIS; METFORMIN
AB Objectives. Nonalcoholic steatohepatitis (NASH) can progress to advanced fibrosis; the link between intestinal bacterial overgrowth and NASH has been proposed. Gut microbiota may promote inflammation and provoke disease progression. We evaluated gut microbiota pattern in NASH and its influencing factors. Methods. A case-controlled study with sixteen NASH and eight control subjects was done. We performed DNA extraction from stool samples and bacterial 16S rRNA sequencing using MiSeq (TM). The sequences were clustered into operational taxonomic units using Quantitative Insights Into Microbial Ecology software. We calculated relative abundances, determined alpha diversity, obtained beta diversity by principal coordinate analysis, and conducted the partial least-squares regression model. Results. The relative abundance of Bacteroidetes tended to be higher in NASH group. The Bacteroidetes/Firmicutes (B/F) ratio was significantly elevated in NASH patients. The pattern of gut microbiota in NASH was clearly separated from that of control subjects. Factors influencing the separation of NASH from control subjects were age, diabetes, body mass index, Bacteroidetes phylum, metformin, Actinobacteria, Verrucomicrobia, Thermotogae, and Caldithrix and Bacteroidetes/Firmicutes ratio. Conclusions. Bacteroidetes phylum (Bacteroides and Prevotella genus) is abundant in NASH subjects, who exhibited an elevated B/F ratio. NASH patients showed a specific pattern of gut microbiota independent of diabetes or metformin use.
C1 [Sobhonslidsuk, Abhasnee; Kaewduang, Piyaporn; Promson, Kwannapa; Petraksa, Supanna] Mahidol Univ, Ramathibodi Hosp, Fac Med, Div Gastroenterol & Hepatol,Dept Med, Bangkok, Thailand.
   [Chanprasertyothin, Suwannee; Pongrujikorn, Tanjitti] Mahidol Univ, Ramathibodi Hosp, Fac Med, Off Res Acad & Innovat, Bangkok, Thailand.
   [Ongphiphadhanakul, Boonsong] Mahidol Univ, Ramathibodi Hosp, Fac Med, Div Endocrinol,Dept Med, Bangkok, Thailand.
C3 Mahidol University; Mahidol University; Mahidol University
RP Sobhonslidsuk, A (通讯作者)，Mahidol Univ, Ramathibodi Hosp, Fac Med, Div Gastroenterol & Hepatol,Dept Med, Bangkok, Thailand.
EM abhasnee.sob@mahidol.ac.th
RI chanprasertyothin, suwannee/R-3025-2019
OI Sobhonslidsuk, Abhasnee/0000-0002-3730-5532
FU Faculty of Medicine, Ramathibodi Hospital, Mahidol University
FX This study was funded by the Faculty of Medicine, Ramathibodi Hospital,
   Mahidol University.
CR Andoh A, 2016, J CLIN BIOCHEM NUTR, V59, P65, DOI 10.3164/jcbn.15-152
   Boursier J, 2016, HEPATOLOGY, V63, P764, DOI 10.1002/hep.28356
   Buzzetti E, 2016, METABOLISM, V65, P1038, DOI 10.1016/j.metabol.2015.12.012
   Damms-Machado A, 2015, BIOMED RES INT, V2015, DOI 10.1155/2015/806248
   Deda O, 2015, J PHARMACEUT BIOMED, V113, P137, DOI 10.1016/j.jpba.2015.02.006
   Duft RG, 2017, J PROTEOME RES, V16, P2151, DOI 10.1021/acs.jproteome.6b00967
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Gemming L, 2014, EUR J CLIN NUTR, V68, P259, DOI 10.1038/ejcn.2013.242
   KEYS A, 1972, J CHRON DIS, V25, P329, DOI 10.1016/0021-9681(72)90027-6
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Mariat D, 2009, BMC MICROBIOL, V9, DOI 10.1186/1471-2180-9-123
   McDonald D, 2012, ISME J, V6, P610, DOI 10.1038/ismej.2011.139
   Mehmood T, 2012, CHEMOMETR INTELL LAB, V118, P62, DOI 10.1016/j.chemolab.2012.07.010
   Mirsepasi Hengameh, 2014, BMC Res Notes, V7, P50, DOI 10.1186/1756-0500-7-50
   Moeller AH, 2013, GUT MICROBES, V4, P403, DOI 10.4161/gmic.26039
   Mouzaki M, 2013, HEPATOLOGY, V58, P120, DOI 10.1002/hep.26319
   Qin JJ, 2010, NATURE, V464, P59, DOI 10.1038/nature08821
   Raman M, 2013, CLIN GASTROENTEROL H, V11, P868, DOI 10.1016/j.cgh.2013.02.015
   Rowell Rachel J, 2015, Clin Med (Lond), V15 Suppl 6, ps77, DOI 10.7861/clinmedicine.15-6-s77
   Sasso M, 2012, CLIN RES HEPATOL GAS, V36, P13, DOI 10.1016/j.clinre.2011.08.001
   Sayiner M, 2016, CLIN LIVER DIS, V20, P205, DOI 10.1016/j.cld.2015.10.001
   Sobhonslidsuk Abhasnee, 2015, Asian Pac J Cancer Prev, V16, P1789
   Stadlbauer V, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0141399
   Tedjo DI, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0126685
   Tong M., 2014, CURRENT PROTOCOLS IM, V107
   van Best N, 2015, HEPATOL INT, V9, P406, DOI 10.1007/s12072-015-9640-2
   Wigg AJ, 2001, GUT, V48, P206, DOI 10.1136/gut.48.2.206
   Wong VWS, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0062885
   Wong VWS, 2010, HEPATOLOGY, V51, P454, DOI 10.1002/hep.23312
   Yeh MM, 2014, GASTROENTEROLOGY, V147, P754, DOI 10.1053/j.gastro.2014.07.056
   Younossi Z, 2016, GASTROENTEROLOGY, V150, P1778, DOI 10.1053/j.gastro.2016.03.005
   Younossi ZM, 2015, HEPATOLOGY, V62, p739A
   Yu JS, 2016, GASTROENT RES PRACT, V2016, DOI 10.1155/2016/2862173
   Zhang XQ, 2015, SCI REP-UK, V5, DOI 10.1038/srep10737
   Zhu LX, 2013, HEPATOLOGY, V57, P601, DOI 10.1002/hep.26093
NR 35
TC 43
Z9 45
U1 1
U2 5
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT
JI Biomed Res. Int.
PY 2018
VL 2018
AR 9340316
DI 10.1155/2018/9340316
PG 8
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA FS7XU
UT WOS:000422623800001
PM 29682571
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Li, LY
   Huang, GX
   Chen, TB
   Lin, H
   Xu, RY
   Cheng, JY
   Hu, Y
   Dai, WB
   Dong, GT
AF Li, Leyu
   Huang, Guoxin
   Chen, Tingbo
   Lin, Hui
   Xu, Ruiyan
   Cheng, Jinyan
   Hu, Ying
   Dai, Weibo
   Dong, Gengting
TI Fufang Fanshiliu Decoction Revealed the Antidiabetic Effect through
   Modulating Inflammatory Response and Gut Microbiota Composition
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID AKKERMANSIA-MUCINIPHILA; METFORMIN
AB Background. Diabetes mellitus brings serious threats and financial burdens to human beings worldwide. Fufang Fanshiliu decoction (FFSLD), a traditional Chinese medicine formula showing great antidiabetic effects, has been used in clinics for many years. Objective. This study aims to explore the underlying therapeutic mechanisms of FFSLD in Type II diabetes mellitus (T2DM). Methods. Sprague-Dawley rats induced by high-fat diet feeding combined with streptozotocin injection were used to establish the T2DM model. All rats were randomly divided into 6 groups: control, model, metformin, high dosage, middle dosage, and low dosage of FFSLD. After 4 weeks of treatment, serum, intestinal mucosa, and fecal samples were collected for further analysis. ELISA was used to detect the diabetic-related serum indicators and proinflammation cytokines. Gene or protein expressions of mitogen-activated protein kinase (MAPK), interleukin 1 beta (IL-1 beta), transforming growth factor-beta (TGF-beta), and tumor necrosis factor-alpha (TNF-alpha) in intestinal mucosa were analyzed by quantitative real-time polymerase chain reaction (RT-PCR) or western blot. 16s rRNA gene sequencing was used to detect the changes of gut microbiome in these groups. Intestinal gut microbiota (GM) composition was further analyzed according to the sequencing libraries. Results. FFSLD effectively recovered the diabetic-related biochemical indexes by reducing fasting blood glucose (FBG), total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), insulin, and increasing high-density lipoprotein cholesterol (HDL-C). Furthermore, FFSLD significantly ameliorated the abnormal levels of proinflammation cytokines including IL-1 beta, IL-6, TNF-alpha, and TGF-beta. In addition, the GM compositions of rats in control, model, and FFSLD treated groups were different. FFSLD significantly increased the relative abundance of Lactobacillus, Akkermansia, and Proteus, and reduced the relative abundance of Alistipes, Desulfovibrio, and Helicobacter. Moreover, these changed bacteria were closely related to the diabetic-related serum indicators and proinflammatory cytokines. Conclusion. These results suggest that FFSLD alleviates diabetic symptoms in T2DM rats through regulating GM composition and inhibiting inflammatory response, which clarify the therapeutic mechanism of FFSLD on T2DM and provide a theoretical basis for its further clinical application.
C1 [Li, Leyu; Lin, Hui; Xu, Ruiyan; Cheng, Jinyan; Hu, Ying; Dai, Weibo; Dong, Gengting] Zhongshan Hosp Tradit Chinese Med, Pharmacol Lab, Zhongshan, Guangdong, Peoples R China.
   [Huang, Guoxin] Shantou Cent Hosp, Clin Res Ctr, Shantou, Guangdong, Peoples R China.
   [Chen, Tingbo] Zhongshan Torch Polytech, Coll Hlth Ind, Zhongshan, Guangdong, Peoples R China.
RP Dai, WB; Dong, GT (通讯作者)，Zhongshan Hosp Tradit Chinese Med, Pharmacol Lab, Zhongshan, Guangdong, Peoples R China.
EM lileyu@139.com; hgvxin@163.com; ctb1257@163.com; 1176849823@qq.com;
   54237982@qq.com; 582398837@qq.com; 64460266@qq.com; daiweibo007@163.com;
   donggengting@163.com
FU project of Guangdong Basic and Applied Basic Research Foundation
   [2022A1515011307]; project of Administration of Traditional Chinese
   Medicine of Guangdong Province of China [20182170]; project of Science
   and Technology Bureau of Zhongshan, Guangdong, China [2018B1010,
   2019B1044]; Guangdong doctoral workstation
FX This work was supported by the project of Guangdong Basic and Applied
   Basic Research Foundation (no. 2022A1515011307), project of
   Administration of Traditional Chinese Medicine of Guangdong Province of
   China (no. 20182170), project of Science and Technology Bureau of
   Zhongshan, Guangdong, China (no. 2018B1010 and 2019B1044). It was also
   supported by the funds of Guangdong doctoral workstation.
CR Adeshirlarijaney A, 2020, GUT MICROBES, V11, P253, DOI 10.1080/19490976.2020.1717719
   Cani PD, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.01765
   Chavez-Carbajal A, 2020, MICROORGANISMS, V8, DOI 10.3390/microorganisms8010094
   Chen Q, 1995, PRACTICAL CLIN HERB, Vsecond
   Cheng L.L., 2016, J GUANGZHOU U TRADIT, V33, P4
   Cheng LH, 2022, FOOD FUNCT, V13, P5240, DOI [10.1039/d2fo00165a, 10.1039/D2FO00165A]
   Dai WB, 2022, J ETHNOPHARMACOL, V294, DOI 10.1016/j.jep.2022.115338
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Di S, 2021, J ETHNOPHARMACOL, V276, DOI 10.1016/j.jep.2021.114180
   Donath MY, 2011, NAT REV IMMUNOL, V11, P98, DOI 10.1038/nri2925
   Dong BB, 2018, BMC ANESTHESIOL, V18, DOI 10.1186/s12871-017-0466-4
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Fan Y, 2021, NAT REV MICROBIOL, V19, P55, DOI 10.1038/s41579-020-0433-9
   Faselis C, 2020, CURR VASC PHARMACOL, V18, P117, DOI 10.2174/1570161117666190502103733
   Flory J, 2019, JAMA-J AM MED ASSOC, V321, P1926, DOI 10.1001/jama.2019.3805
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Gilbert JA, 2018, NAT MED, V24, P392, DOI 10.1038/nm.4517
   Gurung M, 2020, EBIOMEDICINE, V51, DOI 10.1016/j.ebiom.2019.11.051
   Hu J, 2020, J AGR FOOD CHEM, V68, P10441, DOI 10.1021/acs.jafc.0c01893
   Huang GX, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-12644-5
   Hur KY, 2015, J DIABETES INVEST, V6, P600, DOI 10.1111/jdi.12328
   Jafari-Maskouni S, 2020, NUTR METAB, V17, DOI 10.1186/s12986-020-00494-4
   Kirpichnikov D, 2002, ANN INTERN MED, V137, P25, DOI 10.7326/0003-4819-137-1-200207020-00009
   Liu SW, 2021, FOOD RES INT, V142, DOI 10.1016/j.foodres.2021.110239
   Liu YW, 2010, BIOCHEM BIOPH RES CO, V399, P49, DOI 10.1016/j.bbrc.2010.07.037
   Liu Z., 2022, FOOD FUNCTION
   Lyu KB, 2021, BIOSCIENCE REP, V41, DOI 10.1042/BSR20210977
   Ma QT, 2019, BIOMED PHARMACOTHER, V117, DOI 10.1016/j.biopha.2019.109138
   Pezhman L, 2021, FRONT CELL DEV BIOL, V9, DOI 10.3389/fcell.2021.624184
   Saeedi P, 2020, DIABETES RES CLIN PR, V162, DOI 10.1016/j.diabres.2020.108086
   Wong YH, 2022, PANMINERVA MED, V64, P274, DOI 10.23736/S0031-0808.21.04285-3
   Wu CC, 2011, EXP DIABETES RES, DOI 10.1155/2011/514738
   Xia WR, 2020, EVID-BASED COMPL ALT, V2020, DOI 10.1155/2020/8097021
   Xia WR, 2020, PHARMACOL RES, V159, DOI 10.1016/j.phrs.2020.104809
   Yu SJ, 2019, BIOMED RES INT, V2019, DOI 10.1155/2019/5280514
   Zheng Y, 2018, NAT REV ENDOCRINOL, V14, P88, DOI 10.1038/nrendo.2017.151
   Zhou Z, 2022, FRONT CELL INFECT MI, V12, DOI 10.3389/fcimb.2022.834485
NR 37
TC 3
Z9 3
U1 3
U2 4
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PD OCT 10
PY 2022
VL 2022
AR 3255401
DI 10.1155/2022/3255401
PG 10
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 5U4HG
UT WOS:000876509400006
PM 36262166
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Whang, A
   Nagpal, R
   Yadav, H
AF Whang, Andrew
   Nagpal, Ravinder
   Yadav, Hariom
TI Bi-directional drug-microbiome interactions of anti-diabetics
SO EBIOMEDICINE
LA English
DT Review
DE Diabetes; Drugs; Metformin; Microbiome; Type-2 diabetes; Probiotics;
   Prebiotics
ID ALPHA-GLUCOSIDASE INHIBITOR; GUT MICROBIOTA; LACTOBACILLUS-ACIDOPHILUS;
   ANTIDIABETIC DRUGS; METFORMIN ALTERS; INNATE IMMUNITY; FECAL FAT;
   OBESITY; DIET; RISK
AB Type 2 diabetes (T2D) has become a global epidemic. Although several drugs are available to manage T2D, problems associated with person-to-person variability in drug efficacy and potential side-effects remain unresolved. Owing to the emerging role of the gut microbiome in obesity and T2D, the interaction between gut microbes and anti-diabetic drugs and its influence on drugs' functions remains of immediate research interest. On one hand, drugs can manipulate gut microbiome composition and metabolic capacity. Conversely, the metabolic activities of the microbiome and its metabolites can also influence drug metabolism and effects. Hence, understanding this bi-directional drug-microbiome interaction and how it influences the clinical outcomes of antidiabetic drugs can pave the way to develop next-generation strategies to ameliorate diabetes. This review presents evidences demonstrating the putative interactions between anti-diabetic drugs and the gut microbiome, and discusses the potential of microbiome modulators to manipulate drug-microbiome interactions and the drug metabolism. (c) 2018 The Authors. Published by Elsevier B.V.
C1 [Whang, Andrew; Nagpal, Ravinder; Yadav, Hariom] Wake Forest Sch Med, Dept Internal Med Mol Med, Dept Microbiol & Immunol, Winston Salem, NC USA.
C3 Wake Forest University
RP Yadav, H (通讯作者)，Wake Forest Sch Med, Dept Microbiol & Immunol, Dept Internal Med Mol Med, Ctr Diabet Obes & Metab, Winston Salem, NC 27101 USA.
EM hyadav@wakehealth.edu
RI Nagpal, Ravinder/H-5358-2019; Yadav, Hariom/I-2455-2018
OI Nagpal, Ravinder/0000-0002-4250-1749; Yadav, Hariom/0000-0003-4504-1597
FU Center for Diabetes, Obesity and Metabolism at Wake Forest School of
   Medicine; Center of Cardiovascular Sciences at Wake Forest School of
   Medicine; Claude D. Pepper Older Americans Center (NIH) at Wake Forest
   School of Medicine [P30AG12232]; Clinical and Translational Science
   Center (NIH) at Wake Forest School of Medicine [UL1TR001420]; Department
   of Defense funding [PR170446]
FX The authors gratefully acknowledge funding support for this work from
   the Center for Diabetes, Obesity and Metabolism; the Center of
   Cardiovascular Sciences, the Claude D. Pepper Older Americans Center
   (funded by NIH P30AG12232); and the Clinical and Translational Science
   Center (funded by NIH UL1TR001420), all at Wake Forest School of
   Medicine. We also acknowledge support from Department of Defense funding
   (Grant number: PR170446).
CR Al-Hilal TA, 2013, ADV DRUG DELIVER REV, V65, P845, DOI 10.1016/j.addr.2012.11.002
   Al-Suwailem A. K., 2006, J APPL SCI RES, V2, P205
   Anderson PD, 2007, J CLIN ENDOCR METAB, V92, P2272, DOI 10.1210/jc.2006-2545
   Aquilante CL, 2010, EXPERT REV CARDIOVAS, V8, P359, DOI 10.1586/ERC.09.154
   Baggio LL, 2007, GASTROENTEROLOGY, V132, P2131, DOI 10.1053/j.gastro.2007.03.054
   Bai J, 2016, J ETHNOPHARMACOL, V194, P717, DOI 10.1016/j.jep.2016.10.043
   Bank HSD, ORL
   Bauer PV, 2018, CELL METAB, V27, P101, DOI 10.1016/j.cmet.2017.09.019
   Berger JP, 2005, TRENDS PHARMACOL SCI, V26, P244, DOI 10.1016/j.tips.2005.03.003
   Bhute SS, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.00214
   Braissant O, 1996, ENDOCRINOLOGY, V137, P354, DOI 10.1210/en.137.1.354
   Brunkhorst C, 1999, J BACTERIOL, V181, P2612, DOI 10.1128/JB.181.8.2612-2619.1999
   Buteau J, 2003, DIABETES, V52, P124, DOI 10.2337/diabetes.52.1.124
   Byndloss MX, 2017, SCIENCE, V357, P570, DOI 10.1126/science.aam9949
   Cabreiro F, 2013, CELL, V153, P228, DOI 10.1016/j.cell.2013.02.035
   Campbell JE, 2013, CELL METAB, V17, P819, DOI 10.1016/j.cmet.2013.04.008
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   Carding Simon, 2015, Microbial Ecology in Health and Disease, V26, P26191, DOI 10.3402/mehd.v26.26191
   Chan CW, 2018, CARDIOVASC DIABETOL, V17, DOI 10.1186/s12933-018-0663-6
   Chen JJ, 2012, BRIT J NUTR, V107, P1429, DOI 10.1017/S0007114511004491
   Cho SS, 2013, AM J CLIN NUTR, V98, P594, DOI 10.3945/ajcn.113.067629
   De Vadder F, 2014, CELL, V156, P84, DOI 10.1016/j.cell.2013.12.016
   Deacon CF, 2013, EXPERT OPIN PHARMACO, V14, P2047, DOI 10.1517/14656566.2013.824966
   den Besten G, 2015, DIABETES, V64, P2398, DOI 10.2337/db14-1213
   Derrien M, 2011, FRONT MICROBIOL, V2, DOI 10.3389/fmicb.2011.00166
   Devaraj S, 2013, CLIN CHEM, V59, P617, DOI 10.1373/clinchem.2012.187617
   Dewulf EM, 2013, GUT, V62, P1112, DOI 10.1136/gutjnl-2012-303304
   Duca FA, 2015, NAT MED, V21, P506, DOI 10.1038/nm.3787
   Farilla L, 2002, ENDOCRINOLOGY, V143, P4397, DOI 10.1210/en.2002-220405
   Flatt PR, 2008, FRONT BIOSCI-LANDMRK, V13, P3648, DOI 10.2741/2956
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Frost G, 2014, NAT COMMUN, V5, DOI 10.1038/ncomms4611
   GOKE B, 1995, DIGESTION, V56, P493, DOI 10.1159/000201282
   Gu YY, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-01682-2
   Hampp C, 2014, DIABETES CARE, V37, P1367, DOI 10.2337/dc13-2289
   Heisel T, 2017, MSPHERE, V2, DOI [10.1128/mSphere.00351-17, 10.1128/msphere.00351-17]
   Hemker M, 2011, IDENTIFICATION CLONI, P4484
   Hoyles L., 2009, IN VITRO EXAMINATION
   Huo TG, 2015, BIOMED CHROMATOGR, V29, P115, DOI 10.1002/bmc.3247
   Joh EH, 2010, J CHROMATOGR B, V878, P1875, DOI 10.1016/j.jchromb.2010.05.003
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kim DH, 2015, DRUG METAB DISPOS, V43, P1581, DOI 10.1124/dmd.115.063867
   Kishida Y, 2017, J GASTROENTEROL, V52, P1180, DOI 10.1007/s00535-017-1331-4
   Kondo T, 2009, BIOSCI BIOTECH BIOCH, V73, P1837, DOI 10.1271/bbb.90231
   Laferrere B, 2011, SCI TRANSL MED, V3, DOI 10.1126/scitranslmed.3002043
   Lee DM, 2018, CARDIOVASC DIABETOL, V17, DOI 10.1186/s12933-018-0708-x
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Ley RE, 2005, P NATL ACAD SCI USA, V102, P11070, DOI 10.1073/pnas.0504978102
   Li QR, 2014, J CLIN GASTROENTEROL, V48, P513, DOI 10.1097/MCG.0000000000000035
   Lin B, 2014, CARDIOVASC DIABETOL, V13, DOI 10.1186/s12933-014-0148-1
   Ma YF, 2018, MICROBIOME, V6, DOI 10.1186/s40168-018-0410-y
   Madiraju AK, 2014, NATURE, V510, P542, DOI 10.1038/nature13270
   MARUHAMA Y, 1980, TOHOKU J EXP MED, V132, P453, DOI 10.1620/tjem.132.453
   McCreight LJ, 2016, DIABETOLOGIA, V59, P426, DOI 10.1007/s00125-015-3844-9
   Miller RA, 2013, NATURE, V494, P256, DOI 10.1038/nature11808
   Million M, 2012, INT J OBESITY, V36, P817, DOI 10.1038/ijo.2011.153
   Morales P, 2016, CLIN TRANSL GASTROEN, V7, DOI 10.1038/ctg.2016.20
   Nathan DM, 2009, DIABETES CARE, V32, P193, DOI 10.2337/dc08-9025
   Newgard CB, 2009, CELL METAB, V9, P311, DOI 10.1016/j.cmet.2009.02.002
   Olivares M, 2018, DIABETOLOGIA, V61, P1838, DOI 10.1007/s00125-018-4647-6
   Ostman E, 2005, EUR J CLIN NUTR, V59, P983, DOI 10.1038/sj.ejcn.1602197
   Panwar H, 2015, LACTOBACILLI POSSESS
   Pedersen HK, 2016, NATURE, V535, P376, DOI 10.1038/nature18646
   Perry RJ, 2016, NATURE, V534, P213, DOI 10.1038/nature18309
   Plovier H, 2017, NAT MED, V23, P107, DOI 10.1038/nm.4236
   Rahmoune H, 2005, DIABETES, V54, P3427, DOI 10.2337/diabetes.54.12.3427
   Reimer RA, 2014, J ENDOCRINOL, V220, P361, DOI 10.1530/JOE-13-0484
   Rizzo M, 2005, CURRENT KNOWLEDGE FU, V16, P281
   Rosario D, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.00775
   Scheen AJ, 2013, NAT REV CARDIOL, V10, P73, DOI 10.1038/nrcardio.2012.183
   Sedeek M, 2013, CLIN SCI, V124, P191, DOI 10.1042/CS20120330
   Shen Y, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-01619-1
   Shi H, 2006, J CLIN INVEST, V116, P3015, DOI 10.1172/JCI28898
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Standl E, 2001, DIABETES RES CLIN PR, V51, P205, DOI 10.1016/S0168-8227(00)00231-X
   Su BL, 2015, J DIABETES, V7, P729, DOI 10.1111/1753-0407.12232
   Tomas J, 2016, P NATL ACAD SCI USA, V113, pE5934, DOI 10.1073/pnas.1612559113
   Tong XL, 2018, MBIO, V9, DOI 10.1128/mBio.02392-17
   Torgerson JS, 2004, DIABETES CARE, V27, P155, DOI 10.2337/diacare.27.1.155
   Tralau T, 2015, EXPERT OPIN DRUG MET, V11, P411, DOI 10.1517/17425255.2015.990437
   Ussar S, 2015, CELL METAB, V22, P516, DOI 10.1016/j.cmet.2015.07.007
   Wang L, 2016, SCI REP-UK, V6, DOI [10.1038/srep38380, 10.1038/srep33251, 10.1038/srep20004]
   Wang TJ, 2011, NAT MED, V17, P448, DOI 10.1038/nm.2307
   Wehmeier UF, 2004, APPL MICROBIOL BIOT, V63, P613, DOI 10.1007/s00253-003-1477-2
   Woting A, 2016, NUTRIENTS, V8, DOI 10.3390/nu8040202
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Xu F, 2009, DIABETES, V58, pA3, DOI 10.2337/db08-1637
   Yadav H, 2007, NUTRITION, V23, P62, DOI 10.1016/j.nut.2006.09.002
   Yadav H, 2006, BIOSCI BIOTECH BIOCH, V70, P1255, DOI 10.1271/bbb.70.1255
   Yadav H, 2016, WORLD J DIABETES, V7, P316, DOI 10.4239/wjd.v7.i15.316
   Yadav H, 2013, J BIOL CHEM, V288, P25088, DOI 10.1074/jbc.M113.452516
   Yadav H, 2008, J DAIRY RES, V75, P189, DOI 10.1017/S0022029908003129
   Yan XF, 2016, J DIABETES RES, V2016, DOI 10.1155/2016/2093171
   Yoo DH, 2014, DRUG METAB DISPOS, V42, P1508, DOI 10.1124/dmd.114.058354
   Zhang QQ, 2016, MEDICINA-LITHUANIA, V52, P28, DOI 10.1016/j.medici.2015.11.008
   Zhang XY, 2017, DIABETES THER, V8, P293, DOI 10.1007/s13300-017-0226-y
   Zhang XQ, 2015, SCI REP-UK, V5, DOI 10.1038/srep10737
   Zhang Y., 2013, FOOD SCI HUM WELL, V2, P167, DOI [10.1016/j.fshw.2013.09.002, DOI 10.1016/J.FSHW.2013.09.002]
   ZHI J, 1994, CLIN PHARMACOL THER, V56, P82, DOI 10.1038/clpt.1994.104
NR 99
TC 53
Z9 54
U1 4
U2 29
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2352-3964
J9 EBIOMEDICINE
JI EBioMedicine
PD JAN
PY 2019
VL 39
BP 591
EP 602
DI 10.1016/j.ebiom.2018.11.046
PG 12
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA HI8AK
UT WOS:000456677400064
PM 30553752
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Liu, GM
   Bei, J
   Liang, L
   Yu, GY
   Li, L
   Li, QH
AF Liu, Guimei
   Bei, Jia
   Liang, Li
   Yu, Guoyong
   Li, Lu
   Li, Quanhong
TI Stachyose Improves Inflammation through Modulating Gut Microbiota of
   High-Fat Diet/Streptozotocin-Induced Type 2 Diabetes in Rats
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Article
DE gut microbiota; inflammatory cytokines; metformin; stachyose; type 2
   diabetes
ID ALPHA-GALACTO-OLIGOSACCHARIDES; GROWTH; PURIFICATION; BACTEROIDES;
   METAGENOME; GLUCOSE; OBESITY
AB ScopeThe present study is undertaken to assess the effects of stachyose (STS) on type 2 diabetes in rats and changes in the gut microbiota compared to metformin (MET).
   Methods and resultsThe type 2 diabetic model is successfully established via a high-fat diet /streptozotocin in Wistar rats, and STS or MET is administered for 4 weeks. Blood is collected to analyze biochemical parameters, pancreas for mRNA expression of related gene, and contents of colon for gut microbiota. STS or MET decreases serum LPS, mRNA expression of IL-6, and tumor necrosis factor- (TNF-). In addition, STS and MET show a similar shifting of the structure of the gut microbiota and a selective enrichment of key species. At the genus level, STS shows selective enrichment of Phascolarctobacterium, Bilophila, Oscillospira, Turicibacter, and SMB5, but MET demonstrates a selective effect on Sutterella, Prevotella, 02d06, and rc4. The correlation analysis indicates that STS and MET decrease IL-6 and TNF- and increase Akt/PI3K expression, which are relative to key species of gut microbiota.
   ConclusionSTS decreases pancreatic mRNA expression of IL-6 and TNF- via key species of gut microbiota. The mechanism of this effect is similar to that of MET.
C1 [Liu, Guimei; Liang, Li; Yu, Guoyong; Li, Quanhong] China Agr Univ, Coll Food Sci & Nutr Engn, Beijing Adv Innovat Ctr Food Nutr & Human Hlth, Beijing, Peoples R China.
   [Liu, Guimei; Bei, Jia; Liang, Li; Yu, Guoyong; Li, Lu; Li, Quanhong] Natl Engn Res Ctr Fruit & Vegetable Proc, Beijing, Peoples R China.
   [Liu, Guimei; Bei, Jia; Liang, Li; Yu, Guoyong; Li, Lu; Li, Quanhong] Beijing Key Lab Food Nonthermal Proc, Beijing, Peoples R China.
C3 China Agricultural University
RP Li, QH (通讯作者)，China Agr Univ, Coll Food Sci & Nutr Engn, Beijing Adv Innovat Ctr Food Nutr & Human Hlth, Beijing, Peoples R China.; Li, QH (通讯作者)，Natl Engn Res Ctr Fruit & Vegetable Proc, Beijing, Peoples R China.; Li, QH (通讯作者)，Beijing Key Lab Food Nonthermal Proc, Beijing, Peoples R China.
EM quanhong_li@hotmail.com
FU Ministry of Agriculture of People's Republic of China [201303112];
   Beijing Advanced Innovation Center for Food Nutrition and Human Health
FX This project was supported by the fund for agro-scientific research in
   the public interest (Project No. 201303112) from Ministry of Agriculture
   of People's Republic of China. We would like to thank Beijing Advanced
   Innovation Center for Food Nutrition and Human Health for supporting the
   opening fund.
CR Ahmadi S., 2016, BR J NUTR, V116, P1
   Bindels LB, 2015, NAT REV GASTRO HEPAT, V12, P303, DOI 10.1038/nrgastro.2015.47
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Choudhary Nikhil, 2008, Iran J Kidney Dis, V2, P72
   Das UN, 2017, FRONT ENDOCRINOL, V8, DOI 10.3389/fendo.2017.00182
   De Naeyer H, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0086235
   Dierking EC, 2009, J PLANT PHYSIOL, V166, P1329, DOI 10.1016/j.jplph.2009.01.008
   Dong Y, 2016, MOLECULES, V21, DOI 10.3390/molecules21111446
   Edgar RC, 2010, BIOINFORMATICS, V26, P2460, DOI 10.1093/bioinformatics/btq461
   Gangola MP, 2014, FOOD CHEM, V154, P127, DOI 10.1016/j.foodchem.2013.12.085
   Gibson G. R., 2010, Food Science and Technology Bulletin: Functional Foods, V7, P1
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Koyasu S, 2003, NAT IMMUNOL, V4, P313, DOI 10.1038/ni0403-313
   Lai Patrick Kwok-Kin, 2012, J Tradit Complement Med, V2, P227
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Lee HB, 2003, J AM SOC NEPHROL, V14, pS241, DOI 10.1097/01.ASN.0000077410.66390.0F
   Li T, 2017, FOOD FUNCT, V8, P262, DOI 10.1039/c6fo01290f
   Li T, 2013, J AGR FOOD CHEM, V61, P11825, DOI 10.1021/jf404160e
   Li WF, 2016, MOL NUTR FOOD RES, V60, P502, DOI 10.1002/mnfr.201500547
   Liu GM, 2017, J DAIRY SCI, V100, P4038, DOI 10.3168/jds.2016-11973
   Livak KJ, 2001, METHODS, V25, P402, DOI 10.1006/meth.2001.1262
   Ma YH, 2014, J DIABETES RES, V2014, DOI 10.1155/2014/493039
   Marti A., 2017, PEDIAT DIABETES
   McDonald D, 2012, ISME J, V6, P610, DOI 10.1038/ismej.2011.139
   Miller DN, 1999, APPL ENVIRON MICROB, V65, P4715
   Na F., 2013, ISME J, V7, P880
   Napolitano A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100778
   Nasri H, 2014, J RES MED SCI, V19, P658
   Niu Q, 2015, SCI REP-UK, V5, DOI 10.1038/srep09938
   Pukacka S, 2009, J PLANT PHYSIOL, V166, P1381, DOI 10.1016/j.jplph.2009.02.013
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Qiu JianGuo, 2011, Zhongcaoyao = Chinese Traditional and Herbal Drugs, V42, P2434
   Rada V, 2008, ANAEROBE, V14, P205, DOI 10.1016/j.anaerobe.2008.05.003
   Ramette A, 2007, FEMS MICROBIOL ECOL, V62, P142, DOI 10.1111/j.1574-6941.2007.00375.x
   Rosario Rey F, 2006, Curr Diab Rep, V6, P455, DOI 10.1007/s11892-006-0079-7
   Sakamoto M, 2012, INT J SYST EVOL MICR, V62, P2637, DOI 10.1099/ijs.0.038638-0
   Scheller J, 2011, BBA-MOL CELL RES, V1813, P878, DOI 10.1016/j.bbamcr.2011.01.034
   Senthilkumar GP, 2018, DIABETES METAB SYND, V12, P23, DOI 10.1016/j.dsx.2017.08.005
   Shin NR, 2015, TRENDS BIOTECHNOL, V33, P496, DOI 10.1016/j.tibtech.2015.06.011
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Singh DP, 2017, PHARMACOL RES, V123, P103, DOI 10.1016/j.phrs.2017.06.015
   Sung HC, 2015, J ETHNOPHARMACOL, V170, P136, DOI 10.1016/j.jep.2015.04.058
   Wexler HM, 2007, CLIN MICROBIOL REV, V20, P593, DOI 10.1128/CMR.00008-07
   Xu J, 2003, SCIENCE, V299, P2074, DOI 10.1126/science.1080029
   Yin JF, 2006, TALANTA, V70, P208, DOI 10.1016/j.talanta.2006.03.027
   Zha LY, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0107655
   Zhang RX, 2004, PHARMAZIE, V59, P552
   Zhang SW, 2017, EXP THER MED, V14, P383, DOI 10.3892/etm.2017.4475
   Zhao L, 2017, FOOD FUNCT, V8, P4644, DOI [10.1039/c7fo01383c, 10.1039/C7FO01383C]
   Zhao LJ, 2017, THER CLIN RISK MANAG, V13, P739, DOI 10.2147/TCRM.S134039
   Zhong YD, 2015, MOL NUTR FOOD RES, V59, P2066, DOI 10.1002/mnfr.201500187
NR 51
TC 65
Z9 68
U1 7
U2 135
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD MAR
PY 2018
VL 62
IS 6
AR 1700954
DI 10.1002/mnfr.201700954
PG 8
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA GA6PA
UT WOS:000428454100003
PM 29341443
DA 2023-06-08
ER

PT J
AU Hashimoto, Y
   Nakajima, H
   Hata, S
   Miyoshi, T
   Hosomi, Y
   Majima, S
   Nakanishi, N
   Senmaru, T
   Osaka, T
   Okada, H
   Ushigome, E
   Hamaguchi, M
   Asano, M
   Yamazaki, M
   Fukui, M
AF Hashimoto, Yoshitaka
   Nakajima, Hanako
   Hata, Shinnosuke
   Miyoshi, Tomoki
   Hosomi, Yukako
   Majima, Saori
   Nakanishi, Naoko
   Senmaru, Takafumi
   Osaka, Takafumi
   Okada, Hiroshi
   Ushigome, Emi
   Hamaguchi, Masahide
   Asano, Mai
   Yamazaki, Masahiro
   Fukui, Michiaki
TI Effect of probiotics, Bifidobacterium bifidum G9-1, on gastrointestinal
   symptoms in patients with type 2 diabetes mellitus: study protocol for
   open-label, single-arm, exploratory research trial (Big STAR study)
SO JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
LA English
DT Article
DE type 2 diabetes; biguanides; probiotics; gut microbiota;
   gastrointestinal complications; constipation; diarrhea
ID GUT MICROBIOTA; METAGENOME; TRANSIT
AB Metformin is associated with risks of gastrointestinal complications in patients with type 2 diabetes. In contrast, probiotic Bifidobacterium bifidum G9-1 (BBG9-1) could improve the symptoms of diarrhea caused by metformin in animal models. Thus, the primary outcome of this study will be the effect of the probiotic BBG9-1 on gastrointestinal symptoms, including diarrhea, in patients with type 2 diabetes who use metformin. This open label, single-arm, and exploratory study will examine 40 patients with type 2 diabetes who use metformin and have symptoms of constipation or diarrhea. After the baseline examination (objective 1), patients will be administered probiotic BBG9-1 for 10 2 weeks. Then, examinations will be performed (objective 2). The primary outcome will be changes in the symptoms of constipation or diarrhea from objective 1 to objective 2. Secondary outcomes will include changes in gut microbiota, and correlations between changes in fecal properties and biomarkers, including HbA1c level and body mass index. This is the first study to investigate the effect of probiotic BBG9-1 on the change in the symptom of constipation or diarrhea in patients with type 2 diabetes who use metformin.
C1 [Hashimoto, Yoshitaka; Nakajima, Hanako; Hata, Shinnosuke; Miyoshi, Tomoki; Hosomi, Yukako; Majima, Saori; Nakanishi, Naoko; Senmaru, Takafumi; Osaka, Takafumi; Okada, Hiroshi; Ushigome, Emi; Hamaguchi, Masahide; Asano, Mai; Yamazaki, Masahiro; Fukui, Michiaki] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Endocrinol & Metab, Kamigyo Ku, Kyoto 6028566, Japan.
C3 Kyoto Prefectural University of Medicine
RP Fukui, M (通讯作者)，Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Endocrinol & Metab, Kamigyo Ku, Kyoto 6028566, Japan.
EM michiaki@koto.kpu-m.ac.jp
RI Hashimoto, Yoshitaka/AAH-8503-2020
OI Hashimoto, Yoshitaka/0000-0002-8794-0550
FU Biofermin Pharmaceutical Co., Ltd.
FX This study, including the article processing charge, will be funded by
   Biofermin Pharmaceutical Co., Ltd. No drugs will be donated or funded by
   the sponsor. No funding bodies had any role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript.
CR Agrawal A, 2009, ALIMENT PHARM THER, V29, P104, DOI 10.1111/j.1365-2036.2008.03853.x
   Blandino G, 2016, DIABETES METAB, V42, P303, DOI 10.1016/j.diabet.2016.04.004
   Brunkwall L, 2017, DIABETOLOGIA, V60, P943, DOI 10.1007/s00125-017-4278-3
   Bytzer P, 2001, ARCH INTERN MED, V161, P1989, DOI 10.1001/archinte.161.16.1989
   Chatterjee S, 2017, LANCET, V389, P2239, DOI 10.1016/S0140-6736(17)30058-2
   Culpepper T, 2016, BENEF MICROBES, V7, P327, DOI 10.3920/BM2015.0156
   Francavilla R, 2019, J CLIN GASTROENTEROL, V53, pE117, DOI 10.1097/MCG.0000000000001023
   Hills RD, 2019, NUTRIENTS, V11, DOI 10.3390/nu11071613
   Ibarra A, 2018, GUT MICROBES, V9, P236, DOI 10.1080/19490976.2017.1412908
   Kalman DS, 2009, BMC GASTROENTEROL, V9, DOI 10.1186/1471-230X-9-85
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Maisey A, 2016, DIABETES THER, V7, P379, DOI 10.1007/s13300-016-0182-y
   Makizaki Y, 2020, BIOSCI MICROB FOOD H, V39, P145, DOI 10.12938/bmfh.2019-022
   Piper Marc S, 2017, Curr Treat Options Gastroenterol, V15, P460, DOI 10.1007/s11938-017-0151-1
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Sanchez-Rangel E, 2017, DIABETOLOGIA, V60, P1586, DOI 10.1007/s00125-017-4336-x
   Singh RK, 2017, J TRANSL MED, V15, DOI 10.1186/s12967-017-1175-y
   Sumitomo Dainippon Pharma Co. Ltd., METGULCO INT
   Zawada AE, 2018, ADV CLIN EXP MED, V27, P567, DOI 10.17219/acem/67961
NR 19
TC 3
Z9 3
U1 2
U2 9
PU JOURNAL CLINICAL BIOCHEMISTRY & NUTRITION
PI KYOTO
PA KYOTO PREFECTURAL UNIV MED, GRAD SCH MEDICAL SCIENCE, DEPT MOLECULAR
   GASTROENTEROLOGY & HEPATOLOGY, KYOTO, 602-8566, JAPAN
SN 0912-0009
EI 1880-5086
J9 J CLIN BIOCHEM NUTR
JI J. Clin. Biochem. Nutr.
PD NOV
PY 2020
VL 67
IS 3
BP 223
EP 227
DI 10.3164/jcbn.20-100
PG 5
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA UE4RT
UT WOS:000687878200001
PM 33293761
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Diener, C
   Reyes-Escogido, MD
   Jimenez-Ceja, LM
   Matus, M
   Gomez-Navarro, CM
   Chu, ND
   Zhong, V
   Tejero, ME
   Alm, E
   Resendis-Antonio, O
   Guardado-Mendoza, R
AF Diener, Christian
   Reyes-Escogido, Maria de Lourdes
   Jimenez-Ceja, Lilia M.
   Matus, Mariana
   Gomez-Navarro, Claudia M.
   Chu, Nathaniel D.
   Zhong, Vivian
   Tejero, M. Elizabeth
   Alm, Eric
   Resendis-Antonio, Osbaldo
   Guardado-Mendoza, Rodolfo
TI Progressive Shifts in the Gut Microbiome Reflect Prediabetes and
   Diabetes Development in a Treatment-Naive Mexican Cohort
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE type 2 diabetes; microbiome; Mexico; metformin; deep phenotyping
ID WIDE ASSOCIATION; INSULIN SENSITIVITY; GLUCOSE-TOLERANCE;
   COLORECTAL-CANCER; PANCREATIC-ISLET; TYPE-2; GENETICS; QUESTIONNAIRE;
   REPLICATION; METAGENOME
AB Type 2 diabetes (T2D) is a global epidemic that affects more than 8% of the world's population and is a leading cause of death in Mexico. Diet and lifestyle are known to contribute to the onset of T2D. However, the role of the gut microbiome in T2D progression remains uncertain. Associations between microbiome composition and diabetes are confounded by medication use, diet, and obesity.
   Here we present data on a treatment-naive cohort of 405 Mexican individuals across varying stages of T2D severity. Associations between gut bacteria and more than 200 clinical variables revealed a defined set of bacterial genera that were consistent biomarkers of T2D prevalence and risk. Specifically, gradual increases in blood glucose levels, beta cell dysfunction, and the accumulation of measured T2D risk factors were correlated with the relative abundances of four bacterial genera. In a cohort of 25 individuals, T2D treatment-predominantly metformin-reliably returned the microbiome to the normoglycemic community state. Deep clinical characterization allowed us to broadly control for confounding variables, indicating that these microbiome patterns were independent of common T2D comorbidities, like obesity or cardiovascular disease. Our work provides the first solid evidence for a direct link between the gut microbiome and T2D in a critically high-risk population. In particular, we show that increased T2D risk is reflected in gradual changes in the gut microbiome. Whether or not these T2D-associated changes in the gut contribute to the etiology of T2D or its comorbidities remains to be seen.
C1 [Diener, Christian; Tejero, M. Elizabeth; Resendis-Antonio, Osbaldo] Inst Nacl Med Genom INMEGEN, Computat Genom, Mexico City, DF, Mexico.
   [Diener, Christian] Inst Syst Biol, Gibbons Lab, Seattle, WA USA.
   [Reyes-Escogido, Maria de Lourdes; Jimenez-Ceja, Lilia M.; Gomez-Navarro, Claudia M.; Guardado-Mendoza, Rodolfo] Univ Guanajuato, Dept Med & Nutr, Metab Res Lab, Leon, Mexico.
   [Matus, Mariana; Chu, Nathaniel D.; Zhong, Vivian; Alm, Eric] MIT, Ctr Microbiome Informat & Therapeut, 77 Massachusetts Ave, Cambridge, MA 02139 USA.
   [Resendis-Antonio, Osbaldo] Univ Nacl Autonoma Mexico, Human Syst Biol Lab, Coordinac Invest Cient Red Apoyo Invest, Mexico City, DF, Mexico.
   [Guardado-Mendoza, Rodolfo] Hosp Reg Alta Especialidad Bajio, Res Dept, Leon, Mexico.
C3 Instituto Nacional de Medicina Genomica; Institute for Systems Biology
   (ISB); Universidad de Guanajuato; Massachusetts Institute of Technology
   (MIT); Universidad Nacional Autonoma de Mexico
RP Resendis-Antonio, O (通讯作者)，Inst Nacl Med Genom INMEGEN, Computat Genom, Mexico City, DF, Mexico.; Guardado-Mendoza, R (通讯作者)，Univ Guanajuato, Dept Med & Nutr, Metab Res Lab, Leon, Mexico.; Resendis-Antonio, O (通讯作者)，Univ Nacl Autonoma Mexico, Human Syst Biol Lab, Coordinac Invest Cient Red Apoyo Invest, Mexico City, DF, Mexico.; Guardado-Mendoza, R (通讯作者)，Hosp Reg Alta Especialidad Bajio, Res Dept, Leon, Mexico.
EM oresendis@inmegen.gob.mx; rguardado@ugto.mx
RI RESENDIS, OSBALDO/ADE-5280-2022; Diener, Christian/X-9574-2019; REYES
   ESCOGIDO, MARIA DE LOURDES/D-4633-2016
OI RESENDIS, OSBALDO/0000-0001-5220-541X; Diener,
   Christian/0000-0002-7476-0868; REYES ESCOGIDO, MARIA DE
   LOURDES/0000-0003-4181-9621; Tejero, Maria Elizabeth/0000-0001-5611-2309
FU CONACYT (Grant Ciencia de Frontera 2019)
   [FORDECYT-PRONACES/425859/2020]; National Institute of Genomic Medicine
   (INMEGEN, Mexico); University of Guanajuato [010/2014, 018/2015,
   1098/2016]; MIT International Science and Technology Initiatives
   (MISTI-2015-2016); CONACYT
FX The authors thank the financial support from CONACYT (Grant Ciencia de
   Frontera 2019, FORDECYT-PRONACES/425859/2020), an internal grant of the
   National Institute of Genomic Medicine (INMEGEN, Mexico), a grant from
   the University of Guanajuato (RG-M, Grants 010/2014, 018/2015, and
   1098/2016), and the MIT International Science and Technology Initiatives
   (MISTI-2015-2016). CG-N received a Ph.D. scholarship from the CONACYT.
CR Ahren B, 2004, EUR J ENDOCRINOL, V150, P97, DOI 10.1530/eje.0.1500097
   Ainsworth BE, 2000, MED SCI SPORT EXER, V32, pS498, DOI 10.1097/00005768-200009001-00009
   Alegre-Diaz J, 2016, NEW ENGL J MED, V375, P1961, DOI 10.1056/NEJMoa1605368
   Amshoff Y, 2018, INT J CANCER, V143, P263, DOI 10.1002/ijc.31311
   Barquera S, 2003, ARCH MED RES, V34, P407, DOI 10.1016/S0188-4409(03)00075-4
   Barquera S, 2013, GLOBALIZATION HEALTH, V9, DOI 10.1186/1744-8603-9-3
   Calgaro M, 2020, GENOME BIOL, V21, DOI 10.1186/s13059-020-02104-1
   Callahan BJ, 2016, NAT METHODS, V13, P581, DOI [10.1038/NMETH.3869, 10.1038/nmeth.3869]
   Caporaso JG, 2012, ISME J, V6, P1621, DOI 10.1038/ismej.2012.8
   Coburn LA, 2019, ONCOGENE, V38, P1067, DOI 10.1038/s41388-018-0492-9
   David LA, 2014, NATURE, V505, P559, DOI 10.1038/nature12820
   de Vos WM, 2013, NATURE, V498, P48, DOI 10.1038/nature12251
   DeFronzo RA, 2015, NAT REV DIS PRIMERS, V1, DOI 10.1038/nrdp.2015.19
   Duvallet C, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-01973-8
   Folli F, 2018, DIABETES OBES METAB, V20, P137, DOI 10.1111/dom.13380
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Fuchsberger C, 2016, NATURE, V536, P41, DOI 10.1038/nature18642
   Gastaldelli A, 2017, DIABETES, V66, P815, DOI 10.2337/db16-1167
   Gevers D, 2014, CELL HOST MICROBE, V15, P382, DOI 10.1016/j.chom.2014.02.005
   Gloor GB, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.02224
   Graessler J, 2013, PHARMACOGENOMICS J, V13, P514, DOI 10.1038/tpj.2012.43
   Guardado-Mendoza R, 2009, P NATL ACAD SCI USA, V106, P13992, DOI 10.1073/pnas.0906471106
   Hall AB, 2017, NAT REV GENET, V18, DOI 10.1038/nrg.2017.63
   Hartstra AV, 2015, DIABETES CARE, V38, P159, DOI 10.2337/dc14-0769
   Hernandez-Avila M, 1998, SALUD PUBLICA MEXICO, V40, P133, DOI 10.1590/S0036-36341998000200005
   Ignatiadis N, 2016, NAT METHODS, V13, P577, DOI [10.1038/NMETH.3885, 10.1038/nmeth.3885]
   Jie ZY, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-00900-1
   Johnson AJ, 2019, CELL HOST MICROBE, V25, P789, DOI 10.1016/j.chom.2019.05.005
   Jurjus A, 2016, BBA CLIN, V5, P16, DOI 10.1016/j.bbacli.2015.11.002
   Kahn SE, 2006, NATURE, V444, P840, DOI 10.1038/nature05482
   Kant R, 2015, GENOME ANNOUNCEMENTS, V3, DOI 10.1128/genomeA.00224-15
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Khor B, 2011, NATURE, V474, P307, DOI 10.1038/nature10209
   Knowler WC, 2002, NEW ENGL J MED, V346, P393, DOI 10.1056/NEJMoa012512
   Levy M, 2015, CELL, V163, P1428, DOI 10.1016/j.cell.2015.10.048
   Ley SH, 2014, LANCET, V383, P1999, DOI 10.1016/S0140-6736(14)60613-9
   Litvak Y, 2018, SCIENCE, V362, P1017, DOI 10.1126/science.aat9076
   Love MI, 2014, GENOME BIOL, V15, DOI 10.1186/s13059-014-0550-8
   Martinez-Gonzalez MA, 2005, PUBLIC HEALTH NUTR, V8, P920, DOI 10.1079/PHN2005745
   Matsuda M, 1999, DIABETES CARE, V22, P1462, DOI 10.2337/diacare.22.9.1462
   McMurdie PJ, 2015, BIOINFORMATICS, V31, P282, DOI 10.1093/bioinformatics/btu616
   Moreno-Estrada A, 2014, SCIENCE, V344, P1280, DOI 10.1126/science.1251688
   Morgan XC, 2012, GENOME BIOL, V13, DOI 10.1186/gb-2012-13-9-r79
   Price ND, 2017, NAT BIOTECHNOL, V35, P747, DOI 10.1038/nbt.3870
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Quast Christian, 2013, Nucleic Acids Res, V41, pD590, DOI 10.1093/nar/gks1219
   Reitmeier S, 2020, CELL HOST MICROBE, V28, P258, DOI 10.1016/j.chom.2020.06.004
   Rothschild D, 2018, NATURE, V555, P210, DOI 10.1038/nature25973
   Ryan PM, 2017, MICROBIOME, V5, DOI 10.1186/s40168-017-0246-x
   SIGMA Type 2 Diabetes Consortium, 2014, Nature, V506, P97, DOI 10.1038/nature12828
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Thaiss CA, 2018, SCIENCE, V359, P1376, DOI 10.1126/science.aar3318
   Tilg H, 2018, CANCER CELL, V33, P954, DOI 10.1016/j.ccell.2018.03.004
   Villarreal-Molina MT, 2008, DIABETES, V57, P509, DOI 10.2337/db07-0484
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Yatsunenko T, 2012, NATURE, V486, P222, DOI 10.1038/nature11053
   Zeggini E, 2008, NAT GENET, V40, P638, DOI 10.1038/ng.120
   Zeggini E, 2007, SCIENCE, V316, P1336, DOI 10.1126/science.1142364
   Zheng Y, 2018, NAT REV ENDOCRINOL, V14, P88, DOI 10.1038/nrendo.2017.151
NR 59
TC 12
Z9 12
U1 2
U2 5
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD JAN 8
PY 2021
VL 11
AR 602326
DI 10.3389/fendo.2020.602326
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA PU9FW
UT WOS:000609604100001
PM 33488518
OA Green Published, gold, Green Submitted
DA 2023-06-08
ER

PT J
AU Barengolts, E
   Green, SJ
   Eisenberg, Y
   Akbar, A
   Reddivari, B
   Layden, BT
   Dugas, L
   Chlipala, G
AF Barengolts, Elena
   Green, Stefan J.
   Eisenberg, Yuval
   Akbar, Arfana
   Reddivari, Bharathi
   Layden, Brian T.
   Dugas, Lara
   Chlipala, George
TI Gut microbiota varies by opioid use, circulating leptin and oxytocin in
   African American men with diabetes and high burden of chronic disease
SO PLOS ONE
LA English
DT Article
ID CATION TRANSPORTER 1; INTESTINAL MICROBIOTA; BETA-GLUCURONIDASES;
   METFORMIN; LACTOBACILLUS; ASSOCIATION; OBESITY; STRESS; EXPRESSION;
   PROBIOTICS
AB Objective
   The gut microbiota is known to be related to type 2 diabetes (T2D), psychiatric conditions, and opioid use. In this study, we tested the hypothesis that variability in gut microbiota in T2D is associated with psycho-metabolic health.
   Methods
   A cross-sectional study was conducted among African American men (AAM) (n = 99) that were outpatients at a Chicago VA Medical Center. The main outcome measures included fecal microbiota ecology (by 16S rRNA gene sequencing), psychiatric disorders including opioid use, and circulating leptin and oxytocin as representative hormone biomarkers for obesity and psychological pro-social behavior.
   Results
   The study subjects had prevalent overweight/obesity (78%), T2D (50%) and co-morbid psychiatric (65%) and opioid use (45%) disorders. In the analysis of microbiota, the data showed interactions of opioids, T2D and metformin with Bifidobacterium and Prevotella genera. The differential analysis of Bifidobacterium stratified by opioids, T2D and metformin, showed significant interactions among these factors indicating that the effect of one factor was changed by the other (FDR-adjusted p [q] < 0.01). In addition, the pair-wise comparison showed that participants with T2D not taking metformin had a significant 6.74 log2 fold increase in Bifidobacterium in opioid users as compared to non-users (q = 2.2 x 10(-8)). Since metformin was not included in this pair-wise comparison, the significant 'q' suggested association of opioid use with Bifidobacterium abundance. The differences in Bifidobacterium abundance could possibly be explained by opioids acting as organic cation transporter 1 (OCT1) inhibitors. Analysis stratified by lower and higher leptin and oxytocin (divided by the 50th percentile) in the subgroup without T2D showed lower Dialister in High-Leptin vs. Low-Leptin (p = 0.03). Contrary, the opposite was shown for oxytocin, higher Dialister in High-Oxytocin vs. Low-Oxytocin (p = 0.04).
   Conclusions
   The study demonstrated for the first time that Bifidobacterium and Prevotella abundance was affected by interactions of T2D, metformin and opioid use. Also, in subjects without T2D Dialister abundance varied according to circulating leptin and oxytocin.
C1 [Barengolts, Elena; Eisenberg, Yuval; Akbar, Arfana; Reddivari, Bharathi; Layden, Brian T.] Univ Illinois, Med Ctr, Dept Med, Chicago, IL 60607 USA.
   [Barengolts, Elena; Layden, Brian T.] Jesse Brown VA Med Ctr, Dept Med, Chicago, IL 60612 USA.
   [Green, Stefan J.] Univ Illinois, DNA Serv Facil, Res Resources Ctr, Chicago, IL USA.
   [Akbar, Arfana; Reddivari, Bharathi] Jesse Brown VA Med Ctr, Div Res & Dev, Chicago, IL USA.
   [Dugas, Lara] Loyola Univ, Dept Publ Hlth Sci, Maywood, IL 60153 USA.
   [Chlipala, George] Univ Illinois, Core Res Informat, Res Resources Ctr, Chicago, IL USA.
C3 University of Illinois System; University of Illinois Chicago;
   University of Illinois Chicago Hospital; US Department of Veterans
   Affairs; Veterans Health Administration (VHA); Jesse Brown VA Medical
   Center; University of Illinois System; University of Illinois Chicago;
   University of Illinois Chicago Hospital; US Department of Veterans
   Affairs; Veterans Health Administration (VHA); Jesse Brown VA Medical
   Center; Loyola University Chicago; University of Illinois System;
   University of Illinois Chicago; University of Illinois Chicago Hospital
RP Barengolts, E (通讯作者)，Univ Illinois, Med Ctr, Dept Med, Chicago, IL 60607 USA.; Barengolts, E (通讯作者)，Jesse Brown VA Med Ctr, Dept Med, Chicago, IL 60612 USA.
EM eibareng@uic.edu
OI Chlipala, George/0000-0003-0203-3191; Dugas, Lara
   Ruth/0000-0002-0692-8585
FU NIDDK NIH HHS [R01 DK104927] Funding Source: Medline; NIH HHS
   [R01DK104927-01A1] Funding Source: Medline; BLRD VA [IK2 BX001587]
   Funding Source: Medline
CR Aguilera M, 2013, MICROB ECOL, V66, P232, DOI 10.1007/s00248-013-0241-0
   Altirriba J, 2015, FRONT ENDOCRINOL, V6, DOI 10.3389/fendo.2015.00119
   [Anonymous], 2015, DIABETES CARE, V38, pS8, DOI 10.2337/dc15-S005
   Bandelow B, 2017, WORLD J BIOL PSYCHIA, V18, P162, DOI 10.1080/15622975.2016.1190867
   Banerjee S, 2016, MUCOSAL IMMUNOL, V9, P1418, DOI 10.1038/mi.2016.9
   Barengolts E, 2016, ENDOCR PRACT, V22, P1224, DOI 10.4158/EP151157.RA
   Barengolts E, 2016, ENDOCR PRACT, V22, P885, DOI 10.4158/EP151192.RA
   Barengolts E, 2015, ENDOCR PRACT, V21, P604, DOI 10.4158/EP14548.OR
   BENJAMINI Y, 1995, J R STAT SOC B, V57, P289, DOI 10.1111/j.2517-6161.1995.tb02031.x
   Christensen MMH, 2011, PHARMACOGENET GENOM, V21, P837, DOI 10.1097/FPC.0b013e32834c0010
   Christian LM, 2015, BRAIN BEHAV IMMUN, V45, P118, DOI 10.1016/j.bbi.2014.10.018
   Ciubotaru I, 2015, TRANSL RES, V166, P401, DOI 10.1016/j.trsl.2015.06.015
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Degenhardt L, 2011, ADDICTION, V106, P32, DOI 10.1111/j.1360-0443.2010.03140.x
   Dujic T, 2016, DIABETIC MED, V33, P511, DOI 10.1111/dme.13040
   Dujic T, 2015, DIABETES, V64, P1786, DOI 10.2337/db14-1388
   Ejtahed HS, 2012, NUTRITION, V28, P539, DOI 10.1016/j.nut.2011.08.013
   Erdman SE, 2016, AGING-US, V8, P3157, DOI 10.18632/aging.101154
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Green SJ, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0128122
   Gu YY, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-01682-2
   Kiraly DD, 2016, SCI REP-UK, V6, DOI 10.1038/srep35455
   Kleiman SC, 2015, PSYCHOSOM MED, V77, P969, DOI 10.1097/PSY.0000000000000247
   Labad J, 2012, PSYCHOSOM MED, V74, P39, DOI 10.1097/PSY.0b013e31823ba8af
   Leclercq S, 2016, CAN J PSYCHIAT, V61, P204, DOI 10.1177/0706743716635535
   Liang X, 2015, ELIFE, V4, DOI 10.7554/eLife.08973
   Martinotti G, 2013, CURR PHARM DESIGN, V19, P6367
   McCarthy DJ, 2012, NUCLEIC ACIDS RES, V40, P4288, DOI 10.1093/nar/gks042
   Messaoudi M, 2011, BRIT J NUTR, V105, P755, DOI 10.1017/S0007114510004319
   Moroti C, 2012, LIPIDS HEALTH DIS, V11, DOI 10.1186/1476-511X-11-29
   Murri M, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-46
   Nakayama J, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.00197
   Pinto -Sanchez MI., 2017, GASTROENTEROLOGY
   Pollet RM, 2017, STRUCTURE, V25, P967, DOI 10.1016/j.str.2017.05.003
   Poretsky R, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0093827
   Poutahidis T, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0078898
   REDDY BS, 1974, SCIENCE, V183, P416, DOI 10.1126/science.183.4123.416
   Seltzer LJ, 2014, CHILD DEV, V85, P501, DOI 10.1111/cdev.12136
   Semenkovich CF, 2015, DIABETES, V64, P3967, DOI 10.2337/db15-0597
   Sinha R, 2013, BIOL PSYCHIAT, V73, P827, DOI 10.1016/j.biopsych.2013.01.032
   Stage TB, 2016, BASIC CLIN PHARMACOL, V118, P487, DOI 10.1111/bcpt.12579
   Tajabadi-Ebrahimi M, 2017, EXP CLIN ENDOCR DIAB, V125, P21, DOI 10.1055/s-0042-105441
   Tonucci LB, 2017, CLIN NUTR, V36, P85, DOI 10.1016/j.clnu.2015.11.011
   Valerio F, 2010, J CLIN GASTROENTEROL, V44, pS49, DOI 10.1097/MCG.0b013e3181d2dca4
   Wallace BD, 2015, CHEM BIOL, V22, P1238, DOI 10.1016/j.chembiol.2015.08.005
   Wan Y, 2015, DIABET METAB SYND OB, V8, P79, DOI 10.2147/DMSO.S50642
   Wang FY, 2017, TOXICOL PATHOL, V45, P150, DOI 10.1177/0192623316679898
   Wang G, 2017, FOOD FUNCT, V8, P3155, DOI 10.1039/c7fo00593h
   Wu XK, 2010, CURR MICROBIOL, V61, P69, DOI 10.1007/s00284-010-9582-9
   Yamaguchi Y, 2016, DIGESTION, V94, P66, DOI 10.1159/000447690
   Yunes RA, 2016, ANAEROBE, V42, P197, DOI 10.1016/j.anaerobe.2016.10.011
   Zhang JJ, 2014, BIOINFORMATICS, V30, P614, DOI 10.1093/bioinformatics/btt593
NR 52
TC 56
Z9 59
U1 3
U2 13
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAR 29
PY 2018
VL 13
IS 3
AR e0194171
DI 10.1371/journal.pone.0194171
PG 22
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA GA8ZI
UT WOS:000428630000018
PM 29596446
OA gold, Green Published, Green Submitted
DA 2023-06-08
ER

PT J
AU Garcia-Beltran, C
   Malpique, R
   Carbonetto, B
   Gonzalez-Torres, P
   Henares, D
   Brotons, P
   Munoz-Almagro, C
   Lopez-Bermejo, A
   de Zegher, F
   Ibanez, L
AF Garcia-Beltran, Cristina
   Malpique, Rita
   Carbonetto, Belen
   Gonzalez-Torres, Pedro
   Henares, Desiree
   Brotons, Pedro
   Munoz-Almagro, Carmen
   Lopez-Bermejo, Abel
   de Zegher, Francis
   Ibanez, Lourdes
TI Gut microbiota in adolescent girls with polycystic ovary syndrome:
   Effects of randomized treatments
SO PEDIATRIC OBESITY
LA English
DT Article
DE gut microbiota; hepatic fat; metformin; PCOS; pioglitazone;
   spironolactone
ID ASSOCIATION; METABOLISM; DIAGNOSIS
AB Background Girls with obesity and polycystic ovary syndrome (PCOS) and women with PCOS have altered gut microbiota. Objective To study the gut microbiota composition of girls with PCOS without obesity (age, 15.8 years; body mass index [BMI] 25 kg/m(2)) and the effects of randomized treatments with an oral contraceptive (OC, N = 15) or with spironolactone-pioglitazone-metformin (SPIOMET, N = 15) for 1 year. Thirty-one age-matched girls served as controls. Methods 16S ribosomal subunit gene amplicon sequencing was performed in stool samples from all subjects; samples from 23 out of 30 girls with PCOS (OC, N = 12; SPIOMET, N = 11) were available for analysis post-treatment. Clinical and endocrine-metabolic variables were measured before and after intervention. Results Girls with PCOS had decreased diversity alpha, altered microbiota pattern and taxonomic profile with more abundance ofFamily XI(P= .002), and less abundance of familyPrevotellaceae(P= .0006) the genusPrevotella(P= .0001) andSenegalimassilia(P < .0001), as compared to controls.Family XIabundance related positively to hepato-visceral fat (R = 0.453;P= .0003). SPIOMET treatment, but not OC, normalized the abundance ofFamily XI.Prevotellaceae,PrevotellaandSenegalimassiliaabundance remained unchanged after either treatment. Conclusion SPIOMET's spectrum of normalizing effects in girls with PCOS is herewith broadened as to includeFamily XIabundance in gut microbiota.
C1 [Garcia-Beltran, Cristina; Malpique, Rita; Ibanez, Lourdes] Univ Barcelona, Endocrinol Dept, Hosp St Joan Deu, Pediat Res Inst, Passeig St Joan Deu,2, Barcelona 08950, Spain.
   [Garcia-Beltran, Cristina; Malpique, Rita; Ibanez, Lourdes] ISCIII, Ctr Invest Biomed Red Diabet & Enfermedades Metab, Madrid, Spain.
   [Carbonetto, Belen; Gonzalez-Torres, Pedro] Micro Syst SL, Barcelona Biomed Res Pk PRBB, Barcelona, Spain.
   [Henares, Desiree; Brotons, Pedro; Munoz-Almagro, Carmen] Hosp St Joan Deu, Pediat Res Inst, Mol Microbiol Dept, Barcelona, Spain.
   [Henares, Desiree; Brotons, Pedro; Munoz-Almagro, Carmen] ISCIII, Ctr Invest Biomed Red Epidemiol & Salud Publ CIBE, Madrid, Spain.
   [Brotons, Pedro; Munoz-Almagro, Carmen] Univ Int Catalunya, Sch Med, Barcelona, Spain.
   [Lopez-Bermejo, Abel] Girona Inst Biomed Res IDIBGI, Pediat Endocrinol Res Grp, Girona, Spain.
   [Lopez-Bermejo, Abel] Dr Josep Trueta Hosp, Girona, Spain.
   [de Zegher, Francis] Univ Leuven, Dept Dev & Regenerat, Leuven, Belgium.
C3 University of Barcelona; CIBER - Centro de Investigacion Biomedica en
   Red; CIBERDEM; Instituto de Salud Carlos III; Pompeu Fabra University;
   University of Barcelona; CIBER - Centro de Investigacion Biomedica en
   Red; CIBERESP; Instituto de Salud Carlos III; Universitat Internacional
   de Catalunya (UIC); Universitat de Girona; Girona University Hospital
   Dr. Josep Trueta; Institut d'Investigacio Biomedica de Girona (IDIBGI);
   Universitat de Girona; Girona University Hospital Dr. Josep Trueta; KU
   Leuven
RP Ibanez, L (通讯作者)，Univ Barcelona, Endocrinol Dept, Hosp St Joan Deu, Pediat Res Inst, Passeig St Joan Deu,2, Barcelona 08950, Spain.
EM libanez@hsjdbcn.org
RI Ibanez, Lourdes/F-8316-2014; Muñoz-Almagro, Carmen/HNR-8695-2023;
   Malpique, Rita MMSM/M-2404-2015; Henares Bonilla, Desiree/K-2543-2017
OI Ibanez, Lourdes/0000-0003-4595-7191; Malpique, Rita
   MMSM/0000-0002-5282-6790; Garcia Beltran, Cristina/0000-0001-6720-7936;
   Lopez-Bermejo, Abel/0000-0002-5828-8911; Henares Bonilla,
   Desiree/0000-0003-2631-2718; Carbonetto, Maria Belen/0000-0002-2784-5324
FU Ministerio de Ciencia e Innovacion, Instituto de Salud Carlos III; Fondo
   Europeo de Desarrollo Regional (FEDER) [PI15/01078]
FX Cristina Garcia-Beltran, Rita Malpique and Lourdes Ibanez are Clinical
   Investigators of CIBERDEM (Centro de Investigacion Biomedica en Red de
   Diabetes y Enfermedades Metabolicas Asociadas, ISC III, Madrid, Spain).
   Abel Lopez-Bermejo is a Clinical Investigator of the I3 Fund for
   Scientific Research (Ministry of Science and Innovation, Spain). This
   study was supported by the Ministerio de Ciencia e Innovacion, Instituto
   de Salud Carlos III, and by the Fondo Europeo de Desarrollo Regional
   (FEDER) (PI15/01078).
CR Adamberg K, 2018, ANAEROBE, V52, P100, DOI 10.1016/j.anaerobe.2018.06.009
   Anderson MJ, 2013, ECOL MONOGR, V83, P557, DOI 10.1890/12-2010.1
   Arumugam M, 2011, NATURE, V473, P174, DOI 10.1038/nature09944
   Azziz R, 2016, NAT REV ENDOCRINOL, V12, P74, DOI 10.1038/nrendo.2015.230
   Bellanger M, 2013, WIRELESS TELECOMMUNICATION SYSTEMS, P95
   Blachnio-Zabielska AU, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19123995
   Bolyen E, 2019, NAT BIOTECHNOL, V37, P852, DOI 10.1038/s41587-019-0209-9
   Bryrup T, 2019, DIABETOLOGIA, V62, P1024, DOI 10.1007/s00125-019-4848-7
   Callahan BJ, 2016, NAT METHODS, V13, P581, DOI [10.1038/NMETH.3869, 10.1038/nmeth.3869]
   Chen YH, 2016, SCI REP-UK, V6, DOI 10.1038/srep24253
   Cohen LJ, 2017, NATURE, V549, P48, DOI 10.1038/nature23874
   D'Aversa Francesca, 2013, Intern Emerg Med, V8 Suppl 1, pS11, DOI 10.1007/s11739-013-0916-z
   de Zegher F, 2018, TRENDS ENDOCRIN MET, V29, P816, DOI 10.1016/j.tem.2018.09.005
   Ejtahed HS, 2019, EUR J ENDOCRINOL, V180, P165, DOI [10.1530/EJE-18-0826, 10.1530/eje-18-0826]
   Everard A, 2013, BEST PRACT RES CL GA, V27, P73, DOI 10.1016/j.bpg.2013.03.007
   Gao K, 2018, PHARMACOL RES, V130, P93, DOI 10.1016/j.phrs.2018.01.011
   Guo Y, 2016, PLASMONICS, V11, P11, DOI [10.1007/s11468-015-0008-1, 10.1371/journal.pone.0156323]
   Hart R, 2015, J CLIN ENDOCR METAB, V100, P911, DOI 10.1210/jc.2014-3886
   Holland WL, 2017, MOL METAB, V6, P267, DOI 10.1016/j.molmet.2017.01.002
   Ibanez L, 2020, J ENDOCR SOC, V4, DOI 10.1210/jendso/bvaa032
   Ibanez L, 2017, HORM RES PAEDIAT, V88, P371, DOI 10.1159/000479371
   Jiang YH, 2020, GYNECOL ENDOCRINOL, V36, P508, DOI 10.1080/09513590.2019.1698026
   Jobira B, 2020, J CLIN ENDOCR METAB, V105, pE2134, DOI 10.1210/clinem/dgz263
   Joham AE, 2014, J CLIN ENDOCR METAB, V99, pE447, DOI 10.1210/jc.2013-2007
   Johnson EL, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-16274-w
   Katoh Kazutaka, 2013, Mol Biol Evol, V30, P772, DOI 10.1093/molbev/mst010
   Kayser BD, 2019, METABOLOMICS, V15, DOI 10.1007/s11306-019-1596-0
   Kho ZY, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.01835
   Kovatcheva-Datchary P, 2015, CELL METAB, V22, P971, DOI 10.1016/j.cmet.2015.10.001
   Ley RE, 2016, NAT REV GASTRO HEPAT, V13, P69, DOI 10.1038/nrgastro.2016.4
   Li J, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-38944-6
   Liu R, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.00324
   Lozupone C, 2011, ISME J, V5, P169, DOI 10.1038/ismej.2010.133
   MANDAL S, 2015, MICROB ECOL HEALTH D, V26, DOI DOI 10.3402/MEHD.V26.27663
   Michail S, 2015, FEMS MICROBIOL ECOL, V91, DOI 10.1093/femsec/fiu002
   Moran LJ, 2017, J MOL ENDOCRINOL, V59, P93, DOI 10.1530/JME-17-0023
   Obata Y, 2018, JCI INSIGHT, V3, DOI 10.1172/jci.insight.99680
   Pedersen HK, 2016, NATURE, V535, P376, DOI 10.1038/nature18646
   Price MN, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009490
   Qi XY, 2019, NAT MED, V25, P1225, DOI 10.1038/s41591-019-0509-0
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Sasaki H, 2019, REPROD BIOMED ONLINE, V38, P570, DOI 10.1016/j.rbmo.2018.12.026
   Sonnenburg JL, 2016, NATURE, V535, P56, DOI 10.1038/nature18846
   Stratford S, 2004, J BIOL CHEM, V279, P36608, DOI 10.1074/jbc.M406499200
   Thackray VG, 2019, TRENDS ENDOCRIN MET, V30, P54, DOI 10.1016/j.tem.2018.11.001
   Torres PJ, 2018, J CLIN ENDOCR METAB, V103, P1502, DOI 10.1210/jc.2017-02153
   Wang Q, 2007, APPL ENVIRON MICROB, V73, P5261, DOI 10.1128/AEM.00062-07
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Zeng B, 2019, RES MICROBIOL, V170, P43, DOI 10.1016/j.resmic.2018.09.002
   Zhu LX, 2013, HEPATOLOGY, V57, P601, DOI 10.1002/hep.26093
NR 50
TC 10
Z9 10
U1 1
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2047-6310
EI 2047-6302
J9 PEDIATR OBES
JI Pediatr. Obes.
PD APR
PY 2021
VL 16
IS 4
AR e12734
DI 10.1111/ijpo.12734
EA SEP 2020
PG 11
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA QS9HO
UT WOS:000573357500001
PM 32989872
DA 2023-06-08
ER

PT J
AU Meng, XL
   Ma, JN
   Kang, AN
   Kang, SY
   Jung, HW
   Park, YK
AF Meng, Xianglong
   Ma, Junnan
   Kang, An Na
   Kang, Seok Yong
   Jung, Hyo Won
   Park, Yong-Ki
TI A Novel Approach Based on Metabolomics Coupled With Intestinal Flora
   Analysis and Network Pharmacology to Explain the Mechanisms of Action of
   Bekhogainsam Decoction in the Improvement of Symptoms of
   Streptozotocin-Induced Diabetic Nephropathy in Mice
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE Bekhogainsam decoction; diabetic nephropathy; metabolomics; gut
   microbiota; network pharmacology
ID ANEMARRHENA-ASPHODELOIDES; GLYCYRRHIZIN; RHIZOME; PATHWAYS; MEDICINE;
   PKC
AB Bekhogainsam decoction (BHID), a representative prescription for the treatment of diabetes mellitus (DM) and diabetic complications in both traditional Korean and Chinese medicine, was examined for its ability to ameliorate diabetic nephropathy (DN), and its mechanism of action was evaluated by metabolomics, gut microbiota, and network pharmacology. In this study, male specific pathogen-free C57BL/6 mice were intraperitoneally injected with streptozotocin (STZ, 100 mg/kg) once per day for 3 days consecutively, and were then orally administered BHID at 100 and 500 mg/kg, and metformin at 250 mg/kg once per day for 4 weeks. Our results showed that the administration of BHID to mice with STZ-induced DN prevented physiological and serological changes, structural damage, and kidney dysfunction. Based on a metabolomics test with serum, the profoundly altered metabolites in the BHID treatment group were identified. Thirty-six BHID-related proteins and four signaling pathways, including valine, leucine, and isoleucine biosynthesis, nicotinate and nicotinamide metabolism, tryptophan metabolism, and alanine, aspartate, and glutamate metabolism pathways, were explored. Principal coordinates analysis (PCoA) of the gut microbiota revealed that BHID treatment significantly affected the flora composition. In addition, the network pharmacology analysis revealed that BHID acted through phosphatidylinositol-3-kinase/protein kinase B (PI3K/Akt) and MAPK-related protein targets. Our findings on the anti-DN effects of BHID and its mechanism of action, from the perspective of systems biology, have provided scientific evidence to support the clinical treatment of patients with diabetes, and implied that BHID has the potential to prevent the progression of DN.
C1 [Meng, Xianglong; Ma, Junnan; Kang, An Na; Kang, Seok Yong; Jung, Hyo Won; Park, Yong-Ki] Dongguk Univ, Dept Herbol, Coll Korean Med, Gyeongju, South Korea.
   [Meng, Xianglong] Shanxi Univ Chinese Med, Coll Chinese Mat Med & Food Engn, Expt Teaching Ctr, Jinzhong, Peoples R China.
   [Kang, Seok Yong; Jung, Hyo Won; Park, Yong-Ki] Dongguk Univ, Korean Med R&D Ctr, Gyeongju, South Korea.
C3 Dongguk University; Shanxi University of Chinese Medicine; Dongguk
   University
RP Jung, HW; Park, YK (通讯作者)，Dongguk Univ, Dept Herbol, Coll Korean Med, Gyeongju, South Korea.; Jung, HW; Park, YK (通讯作者)，Dongguk Univ, Korean Med R&D Ctr, Gyeongju, South Korea.
EM tenzing2@hanmail.net; yongki@dongguk.ac.kr
RI Meng, Xiang-Long/GXV-5867-2022
FU Basic Science Research Program through the National Research Foundation
   of Korea (NRF) - Ministry of Education [2016R1D1A2B01012117,
   2016R1D1A1B04935601]
FX This research was supported by the Basic Science Research Program
   through the National Research Foundation of Korea (NRF) funded by the
   Ministry of Education (Grant No. 2016R1D1A2B01012117 &
   2016R1D1A1B04935601).
CR Alicic RZ, 2017, CLIN J AM SOC NEPHRO, V12, P2032, DOI 10.2215/CJN.11491116
   Barko PC, 2018, J VET INTERN MED, V32, P9, DOI 10.1111/jvim.14875
   Barnes S, 2016, J MASS SPECTROM, V51, P461, DOI 10.1002/jms.3782
   Beger RD, 2016, METABOLOMICS, V12, DOI 10.1007/s11306-016-1094-6
   Burge K, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20081912
   Chang AS, 2016, AM J PHYSIOL-RENAL, V310, pF689, DOI 10.1152/ajprenal.00502.2015
   Chang MS, 2006, J ETHNOPHARMACOL, V103, P491, DOI 10.1016/j.jep.2005.08.039
   Colberg SR, 2010, DIABETES CARE, V33, P2692, DOI [10.2337/dc10-1548, 10.2337/dc10-9990]
   Cui X, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19113634
   Ding X., 2007, CHIN TRADIT HERBAL D, V05, P702, DOI [10.3321/j.issn:0253-2670.2007.05.023, DOI 10.3321/J.ISSN:0253-2670.2007.05.023]
   Dong LL, 2019, CHIN MED-UK, V14, DOI 10.1186/s13020-019-0241-1
   Engskog MKR, 2017, AMINO ACIDS, V49, P905, DOI 10.1007/s00726-017-2391-8
   Gao X, 2018, EVID-BASED COMPL ALT, V2018, DOI 10.1155/2018/2503849
   Glastras SJ, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0162131
   Hanning I, 2015, MICROBIOME, V3, DOI 10.1186/s40168-015-0113-6
   Horie M, 2017, EXP ANIM TOKYO, V66, P405, DOI 10.1538/expanim.17-0021
   Hostalek U, 2015, DRUGS, V75, P1071, DOI 10.1007/s40265-015-0416-8
   Jang SE, 2013, BIOMOL THER, V21, P398, DOI 10.4062/biomolther.2013.048
   Kaiser JC, 2018, PLOS GENET, V14, DOI 10.1371/journal.pgen.1007159
   Kikuchi K, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-09735-4
   [李光超 Li Guangchao], 2014, [中国中医基础医学杂志, Chinese Journal of Basic Medicine in Traditional Chinese Medicine], V20, P459
   Li Xiang, 2006, Zhong Xi Yi Jie He Xue Bao, V4, P624
   Li X, 2013, PHYTOTHER RES, V27, P1243, DOI 10.1002/ptr.4866
   Lin HT, 2019, J CLIN MED, V8, DOI 10.3390/jcm8060874
   Lu HJ, 2014, BMC COMPLEM ALTERN M, V14, DOI 10.1186/1472-6882-14-156
   Lu WQ, 2011, CLIN EXP PHARMACOL P, V38, P380, DOI 10.1111/j.1440-1681.2011.05530.x
   Makino T, 2014, J NAT MED-TOKYO, V68, P505, DOI 10.1007/s11418-014-0827-y
   Mancuso C, 2017, FOOD CHEM TOXICOL, V107, P362, DOI 10.1016/j.fct.2017.07.019
   MELLONI E, 1987, P NATL ACAD SCI USA, V84, P5282, DOI 10.1073/pnas.84.15.5282
   Mohanan P, 2018, J GINSENG RES, V42, P123, DOI 10.1016/j.jgr.2017.01.008
   Nijiati Ablat, 2015, Chinese Journal of Information on Traditional Chinese Medicine, V22, P83
   NISHIZUKA Y, 1986, SCIENCE, V233, P305, DOI 10.1126/science.3014651
   Niu HL, 2014, BMC NEPHROL, V15, DOI 10.1186/1471-2369-15-135
   Nose M, 2017, J NAT MED-TOKYO, V71, P711, DOI 10.1007/s11418-017-1101-x
   Piccoli Giorgina B, 2015, Rev Diabet Stud, V12, P87, DOI 10.1900/RDS.2015.12.87
   Rani R, 2017, EUR J PHARM SCI, V106, P220, DOI 10.1016/j.ejps.2017.05.068
   Sajan MP, 2012, DIABETOLOGIA, V55, P1446, DOI 10.1007/s00125-012-2477-5
   Saleem MA, 2015, NEPHROL DIAL TRANSPL, V30, P1266, DOI 10.1093/ndt/gfu363
   Sarkozy M, 2014, BMC ENDOCR DISORD, V14, DOI 10.1186/1472-6823-14-72
   Sen S, 2011, J PHARM PHARMACOL, V63, P287, DOI 10.1111/j.2042-7158.2010.01217.x
   Sil R, 2013, INDIAN J EXP BIOL, V51, P129
   Song ZeBi, 2015, Drugs and Clinic, V30, P145
   Tong XL, 2012, AM J CHINESE MED, V40, P877, DOI 10.1142/S0192415X12500656
   van Stee MF, 2018, CARDIOVASC DIABETOL, V17, DOI 10.1186/s12933-018-0738-4
   Wang R, 2018, DRUG DES DEV THER, V12, P1321, DOI 10.2147/DDDT.S166051
   Wang WW, 2015, CAN J PHYSIOL PHARM, V93, P657, DOI 10.1139/cjpp-2014-0416
   Wang ZJ, 2017, J CELL MOL MED, V21, P2359, DOI 10.1111/jcmm.13157
   Xiao CP, 2016, J GINSENG RES, V40, P28, DOI 10.1016/j.jgr.2015.04.004
   Xiao YH, 2018, MOL MED REP, V17, P6441, DOI 10.3892/mmr.2018.8724
   Xu L, 2016, IUBMB LIFE, V68, P847, DOI 10.1002/iub.1563
   Yang J, 2015, INT J CLIN EXP PATHO, V8, P14925
   Yuan HD, 2017, MOLECULES, V22, DOI 10.3390/molecules22071135
   Zhang BX, 2019, EVID-BASED COMPL ALT, V2019, DOI 10.1155/2019/2634898
   Zhang RZ, 2019, FRONT PHARMACOL, V10, DOI 10.3389/fphar.2019.00123
NR 54
TC 21
Z9 21
U1 7
U2 49
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD MAY 21
PY 2020
VL 11
AR 633
DI 10.3389/fphar.2020.00633
PG 19
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA LW8MZ
UT WOS:000539398900001
PM 32508632
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Liu, WH
   Luo, ZY
   Zhou, JC
   Sun, B
AF Liu, Wenhui
   Luo, Zhiying
   Zhou, Jiecan
   Sun, Bao
TI Gut Microbiota and Antidiabetic Drugs: Perspectives of Personalized
   Treatment in Type 2 Diabetes Mellitus
SO FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
LA English
DT Review
DE gut microbiota; antidiabetic drugs; type 2 diabetes mellitus; efficacy
   and safety; personalized therapeutic targets
ID DOUBLE-BLIND; STRUCTURAL MODULATION; INTESTINAL MICROBIOTA; METFORMIN
   ALTERS; BODY-WEIGHT; GLUCAGON; ACID; IMPROVEMENT; METABOLISM; INSULIN
AB Alterations in the composition and function of the gut microbiota have been reported in patients with type 2 diabetes mellitus (T2DM). Emerging studies show that prescribed antidiabetic drugs distort the gut microbiota signature associated with T2DM. Even more importantly, accumulated evidence provides support for the notion that gut microbiota, in turn, mediates the efficacy and safety of antidiabetic drugs. In this review, we highlight the current state-of-the-art knowledge on the crosstalk and interactions between gut microbiota and antidiabetic drugs, including metformin, alpha-glucosidase inhibitors, glucagon-like peptide-1 receptor agonists, dipeptidyl peptidase-4 inhibitors, sodium-glucose cotransporter 2 inhibitors, traditional Chinese medicines and other antidiabetic drugs, as well as address corresponding microbial-based therapeutics, aiming to provide novel preventative strategies and personalized therapeutic targets in T2DM.
C1 [Liu, Wenhui; Luo, Zhiying; Sun, Bao] Cent South Univ, Xiangya Hosp 2, Dept Pharm, Changsha, Peoples R China.
   [Liu, Wenhui; Luo, Zhiying; Sun, Bao] Cent South Univ, Inst Clin Pharm, Changsha, Peoples R China.
   [Zhou, Jiecan] Univ South China, Affiliated Hosp 1, Inst Clin Med, Hengyang, Peoples R China.
C3 Central South University; Central South University; University of South
   China
RP Sun, B (通讯作者)，Cent South Univ, Xiangya Hosp 2, Dept Pharm, Changsha, Peoples R China.; Sun, B (通讯作者)，Cent South Univ, Inst Clin Pharm, Changsha, Peoples R China.
EM scy_csu2016@csu.edu.cn
FU National Natural Science Foundation of China [82104307, 82003872];
   Natural Science Foundation of Hunan Province [2021JJ40865, 2021JJ40847,
   2020JJ5513]
FX Funding This work was supported by grants from National Natural Science
   Foundation of China (No. 82104307, 82003872), Natural Science Foundation
   of Hunan Province (No. 2021JJ40865, 2021JJ40847, 2020JJ5513).
CR Aoki R, 2017, SCI REP-UK, V7, DOI 10.1038/srep43522
   Aron-Wisnewsky J, 2019, CURR DIABETES REP, V19, DOI 10.1007/s11892-019-1180-z
   Baggio LL, 2014, J CLIN INVEST, V124, P4223, DOI 10.1172/JCI78371
   Bailey CJ, 2008, DIABETOLOGIA, V51, P1552, DOI 10.1007/s00125-008-1053-5
   Bauer PV, 2018, CELL METAB, V27, P101, DOI 10.1016/j.cmet.2017.09.019
   Birkeland E, 2020, EUR J NUTR, V59, P3325, DOI 10.1007/s00394-020-02282-5
   Bock PM, 2021, DIABETOLOGIA, V64, P26, DOI 10.1007/s00125-020-05295-1
   BONORA E, 1984, CURR MED RES OPIN, V9, P47, DOI 10.1185/03007998409109558
   Bouter KE, 2017, GASTROENTEROLOGY, V152, P1671, DOI 10.1053/j.gastro.2016.12.048
   Bryrup T, 2019, DIABETOLOGIA, V62, P1024, DOI 10.1007/s00125-019-4848-7
   Cao TTB, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.573891
   Cao Y, 2019, J DIABETES RES, V2019, DOI 10.1155/2019/1872134
   Charpentier J, 2021, ACTA DIABETOL, V58, P881, DOI 10.1007/s00592-020-01657-8
   Chen H, 2021, EVID-BASED COMPL ALT, V2021, DOI 10.1155/2021/5585952
   Chen MY, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.02380
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Do HJ, 2016, ENDOCR J, V63, P691, DOI 10.1507/endocrj.EJ15-0747
   Doestzada M, 2018, PROTEIN CELL, V9, P432, DOI 10.1007/s13238-018-0547-2
   Drucker DJ, 2006, LANCET, V368, P1696, DOI 10.1016/S0140-6736(06)69705-5
   Du FY, 2018, J PHARMACOL EXP THER, V365, P676, DOI 10.1124/jpet.118.248575
   Ejtahed HS, 2016, HORM METAB RES, V48, P349, DOI 10.1055/s-0042-107792
   Ejtahed HS, 2019, EUR J ENDOCRINOL, V180, P165, DOI [10.1530/EJE-18-0826, 10.1530/eje-18-0826]
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Ghorbani Y, 2021, EUR J NUTR, V60, P2361, DOI 10.1007/s00394-021-02520-4
   GIBSON GR, 1995, J NUTR, V125, P1401, DOI 10.1093/jn/125.6.1401
   Grasset E, 2017, CELL METAB, V25, P1075, DOI 10.1016/j.cmet.2017.04.013
   Groen AK, 2017, EMBO MOL MED, V9, P1, DOI 10.15252/emmm.201607035
   Gu YY, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-01682-2
   Handelsman Y, 2015, ENDOCR PRACT, V21, P1, DOI [10.4158/EP15672.GL, 10.4158/EP15672.GLSUPPL]
   He CX, 2015, NUTR RES, V35, P361, DOI 10.1016/j.nutres.2015.03.002
   Heinken A, 2021, ANNU REV MICROBIOL, V75, P199, DOI 10.1146/annurev-micro-060221-012134
   Hill C, 2014, NAT REV GASTRO HEPAT, V11, P506, DOI 10.1038/nrgastro.2014.66
   Hsieh PS, 2021, PLOS ONE, V16, DOI 10.1371/journal.pone.0251646
   Hu Y, 2016, COMPLEMENT THER MED, V24, P13, DOI 10.1016/j.ctim.2015.11.005
   Huda MN, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.632335
   Huo TG, 2015, BIOMED CHROMATOGR, V29, P115, DOI 10.1002/bmc.3247
   Javdan B, 2020, CELL, V181, P1661, DOI 10.1016/j.cell.2020.05.001
   Kahn Steven E., 2000, American Journal of Medicine, V108, p2S, DOI 10.1016/S0002-9343(00)00336-3
   Kesika P, 2019, BIOMED RES INT, V2019, DOI 10.1155/2019/1531567
   Khoruts A, 2016, NAT REV GASTRO HEPAT, V13, DOI 10.1038/nrgastro.2016.98
   Kim YA, 2018, NUTR RES REV, V31, P35, DOI 10.1017/S095442241700018X
   Kimura I, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms2852
   Knop FK, 2012, DIABETES OBES METAB, V14, P500, DOI 10.1111/j.1463-1326.2011.01549.x
   Kootte RS, 2017, CELL METAB, V26, P611, DOI 10.1016/j.cmet.2017.09.008
   Koppel N, 2017, SCIENCE, V356, DOI 10.1126/science.aag2770
   Koropatkin NM, 2017, CELL METAB, V26, P456, DOI 10.1016/j.cmet.2017.08.022
   Korpela K, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0090702
   Kovatcheva-Datchary P, 2015, CELL METAB, V22, P971, DOI 10.1016/j.cmet.2015.10.001
   Kuriyama C, 2008, BIOORGAN MED CHEM, V16, P7330, DOI 10.1016/j.bmc.2008.06.026
   Lagier JC, 2016, NAT MICROBIOL, V1, DOI [10.1038/NMICROBIOL.2016.203, 10.1038/nmicrobiol.2016.203]
   Lampe JW, 2013, P NUTR SOC, V72, P207, DOI 10.1017/S0029665113000025
   Lee DM, 2018, CARDIOVASC DIABETOL, V17, DOI 10.1186/s12933-018-0708-x
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Lee YS, 2021, FOOD FUNCT, V12, P6363, DOI [10.1039/d1fo00698c, 10.1039/D1FO00698C]
   Li K, 2019, FOOD FUNCT, V10, P1915, DOI 10.1039/c8fo02265h
   Lian FM, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0130550
   Liao XY, 2019, EBIOMEDICINE, V44, P665, DOI 10.1016/j.ebiom.2019.03.057
   Madsen MSA, 2021, BIOMED PHARMACOTHER, V133, DOI 10.1016/j.biopha.2020.110966
   Mahboobi S, 2018, ADV PHARM BULL, V8, P565, DOI 10.15171/apb.2018.065
   Montandon SA, 2017, GENES-BASEL, V8, DOI 10.3390/genes8100250
   Morshedi M, 2020, J TRANSL MED, V18, DOI 10.1186/s12967-019-02169-y
   Mueller NT, 2021, DIABETES CARE, V44, P1462, DOI 10.2337/dc20-2257
   Mulder TP, 2005, AM J CLIN NUTR, V81, p256S, DOI 10.1093/ajcn/81.1.256S
   Nakajima H, 2020, LIFE-BASEL, V10, DOI 10.3390/life10090195
   Natori Y, 2011, BIOORG MED CHEM LETT, V21, P738, DOI 10.1016/j.bmcl.2010.11.112
   Nie QX, 2019, CRIT REV FOOD SCI, V59, P848, DOI 10.1080/10408398.2018.1536646
   Olivares M, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.01900
   Olivares M, 2018, DIABETOLOGIA, V61, P1838, DOI 10.1007/s00125-018-4647-6
   Palacios T, 2020, NUTRIENTS, V12, DOI 10.3390/nu12072041
   Salonen A, 2014, ISME J, V8, P2218, DOI 10.1038/ismej.2014.63
   Shang JJ, 2021, PEERJ, V9, DOI 10.7717/peerj.11128
   Sharma P, 2016, INT J PREVENTIVE MED, V7, DOI 10.4103/2008-7802.188870
   Shilo S, 2022, DIABETES CARE, V45, P502, DOI 10.2337/dc21-1048
   Smith BJ, 2019, BMC MICROBIOL, V19, DOI 10.1186/s12866-019-1494-7
   Spanogiannopoulos P, 2016, NAT REV MICROBIOL, V14, P273, DOI 10.1038/nrmicro.2016.17
   Su BL, 2015, J DIABETES, V7, P729, DOI 10.1111/1753-0407.12232
   Su HM, 2020, OXID MED CELL LONGEV, V2020, DOI 10.1155/2020/6538930
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Tahrani AA, 2013, LANCET DIABETES ENDO, V1, P140, DOI 10.1016/S2213-8587(13)70050-0
   Tan KM, 2018, PROTEIN SCI, V27, P1498, DOI 10.1002/pro.3444
   Toejing P, 2021, FOODS, V10, DOI 10.3390/foods10071455
   Tolhurst G, 2012, DIABETES, V61, P364, DOI 10.2337/db11-1019
   van Bommel EJM, 2020, DIABETES METAB, V46, P164, DOI 10.1016/j.diabet.2019.11.005
   Vazquez-Baeza Y, 2018, ANNU REV PHARMACOL, V58, P253, DOI 10.1146/annurev-pharmtox-042017-031849
   Vettorazzi JF, 2016, METABOLISM, V65, P54, DOI 10.1016/j.metabol.2015.10.021
   Wang L, 2016, SCI REP-UK, V6, DOI [10.1038/srep38380, 10.1038/srep33251, 10.1038/srep20004]
   Wang Y, 2017, THERANOSTICS, V7, P2443, DOI 10.7150/thno.18290
   Wang YM, 2020, PHARMACOL RES, V161, DOI 10.1016/j.phrs.2020.105150
   Wei XY, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-22094-2
   Williams RE, 2002, XENOBIOTICA, V32, P783, DOI 10.1080/00498250210143047
   Woting A, 2016, NUTRIENTS, V8, DOI 10.3390/nu8040202
   Wu GD, 2011, SCIENCE, V334, P105, DOI 10.1126/science.1208344
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Xu J, 2015, ISME J, V9, P552, DOI 10.1038/ismej.2014.177
   Xu T, 2021, J ETHNOPHARMACOL, V273, DOI 10.1016/j.jep.2021.113995
   Xu XZ, 2020, GENOM PROTEOM BIOINF, V18, P721, DOI [10.1016/j.gpb.2019.09.0071672-0229, 10.1016/j.gpb.2019.09.007]
   Yan XF, 2016, J DIABETES RES, V2016, DOI 10.1155/2016/2093171
   Yang M, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.00635
   Yao Y, 2020, BIOMED PHARMACOTHER, V131, DOI 10.1016/j.biopha.2020.110669
   Yu LL, 2021, J MED FOOD, V24, P319, DOI 10.1089/jmf.2020.4759
   Yuan X, 2018, J CELL BIOCHEM, V119, P10067, DOI 10.1002/jcb.27343
   Zhang BX, 2019, EVID-BASED COMPL ALT, V2019, DOI 10.1155/2019/2634898
   Zhang FH, 2019, ENDOCRINE, V66, P485, DOI 10.1007/s12020-019-02041-5
   Zhang PP, 2020, ACTA PHARMACOL SIN, V41, P678, DOI 10.1038/s41401-019-0330-9
   Zhang Q, 2018, EXP BIOL MED, V243, P34, DOI 10.1177/1535370217743765
   Zhang Q, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0184735
   Zhang XY, 2017, DIABETES THER, V8, P293, DOI 10.1007/s13300-017-0226-y
   Zhang YF, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-18414-8
   Zhao L, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00233
   Zheng YJ, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000022233
   Zheng YJ, 2020, FRONT CELL INFECT MI, V10, DOI 10.3389/fcimb.2020.00360
   Zimmermann M, 2019, NATURE, V570, P462, DOI 10.1038/s41586-019-1291-3
NR 112
TC 6
Z9 6
U1 0
U2 5
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2235-2988
J9 FRONT CELL INFECT MI
JI Front. Cell. Infect. Microbiol.
PD MAY 31
PY 2022
VL 12
AR 853771
DI 10.3389/fcimb.2022.853771
PG 12
WC Immunology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Microbiology
GA 2C5EC
UT WOS:000810890700001
PM 35711668
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Tian, RP
   Hong, JH
   Zhao, JJ
   Zhou, DY
   Liu, YC
   Jiao, ZS
   Song, J
   Zhang, Y
   Meng, LZ
   Yu, M
AF Tian, Ruiping
   Hong, Jiahui
   Zhao, Jingjie
   Zhou, Dengyuan
   Liu, Yangchen
   Jiao, Zhenshan
   Song, Jian
   Zhang, Yu
   Meng, Lingzhang
   Yu, Ming
TI Overall Structural Alteration of Gut Microbiota and Relationships with
   Risk Factors in Patients with Metabolic Syndrome Treated with Inulin
   Alone and with Other Agents: An Open-Label Pilot Study
SO MEDIATORS OF INFLAMMATION
LA English
DT Article
AB Objective. The relative contribution of some products with prebiotic effects, such as inulin, together with medications specific to the human gut microbiome has not been comprehensively studied. The present study determined the potential for manipulating populations in the gut microbiome using inulin alone and combined with other agents in individuals with metabolic syndrome (MetS). The study also assessed whether there is relationship variability in multiple clinical parameters in response to intervention with the changes in the gut milieu. Participants/Methods. This single-centre, single-blinded, randomised community-based pilot trial randomly assigned 60 patients (mean age, 46.3 y and male, 43%) with MetS to receive either inulin, inulin+traditional Chinese medicine (TCM), or inulin+metformin for 6 months. Lipid profiles, blood glucose, and uric acid (UA) levels were analysed in venous blood samples collected after overnight fast of 8 h at baseline and at the end of the follow-up period. Microbiota from stool samples were taxonomically analysed using 16S RNA amplicon sequencing, and an integrative analysis was conducted on microbiome and responsiveness data at 6 months. Results. The results of 16S rRNA sequencing showed that inulin resulted in a higher proportion of Bacteroides at the endpoint compared with inulin+TCM and inulin+metformin (p=0.024). More Romboutsia (p=0.043), Streptococcus (p < 0.001), and Holdemanella (p=0.011) were found in inulin+TCM and inulin+metformin samples. We further identified gut microbiota relationships with lipids, UA, and glucose that impact the development of MetS. Conclusion. Among the groups, inulin alone or combined with metformin or TCM altered specific gut microbiota taxa but not the general diversity. Accordingly, we analysed metabolites associated with microbiota that might provide more information about intrinsic differences. Consequently, a reliable method could be developed for treating metabolic syndrome in the future.
C1 [Tian, Ruiping; Hong, Jiahui; Yu, Ming] Tianjin Med Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Tianjin, Peoples R China.
   [Zhao, Jingjie] Youjiang Med Univ Nationalities, Affiliated Hosp, Life Sci & Clin Res Ctr, Baise, Guangxi, Peoples R China.
   [Zhou, Dengyuan; Liu, Yangchen] Community Hlth Serv Ctr Zhongbei Town, Dept Gen Family Med, Xiqing Dist, Tianjin, Peoples R China.
   [Jiao, Zhenshan; Zhang, Yu] Tianjin Acad Tradit Chinese Med Affiliated Hosp, Dept Dermatol, Tianjin, Peoples R China.
   [Song, Jian; Meng, Lingzhang] Youjiang Med Univ Nationalities, Ctr Syst Inflammat Res CSIR, Sch Preclin Med, Baise, Guangxi, Peoples R China.
C3 Tianjin Medical University; Youjiang Medical University for
   Nationalities; Youjiang Medical University for Nationalities
RP Yu, M (通讯作者)，Tianjin Med Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Tianjin, Peoples R China.; Zhang, Y (通讯作者)，Tianjin Acad Tradit Chinese Med Affiliated Hosp, Dept Dermatol, Tianjin, Peoples R China.; Meng, LZ (通讯作者)，Youjiang Med Univ Nationalities, Ctr Syst Inflammat Res CSIR, Sch Preclin Med, Baise, Guangxi, Peoples R China.
EM tianzhiyi8814@qq.com; 184222487@qq.com; jingjie.zhao@ymun.edu.cn;
   18502661352@163.com; 13752245386@163.com; 17336909976@189.cn;
   songj@uni-muenster.de; niuniuzy7375@aliyun.com;
   lingzhang.meng@ymun.edu.cn; minnieyu@tmu.edu.cn
RI Song, Jian/Q-5216-2018
OI Song, Jian/0000-0002-2459-7046; Meng, Lingzhang/0000-0003-4536-8709; ,
   Jian/0000-0003-2159-9190; Zhang, Yu/0000-0001-9317-2466; Zhao,
   Jingjie/0000-0002-1582-2053; Hong, Jiahui/0000-0003-0255-8756
FU Tianjin Municipal Science and Technology Planning Project
   [17ZXMFSY00030]
FX AcknowledgmentsThis study was supported by the Tianjin Municipal Science
   and Technology Planning Project (#17ZXMFSY00030).
CR Balducci S, 2014, DIABETES-METAB RES, V30, P13, DOI 10.1002/dmrr.2514
   Bishehsari F, 2020, NAT REV ENDOCRINOL, V16, P731, DOI 10.1038/s41574-020-00427-4
   Bryrup T, 2019, DIABETOLOGIA, V62, P1024, DOI 10.1007/s00125-019-4848-7
   Byndloss MX, 2017, SCIENCE, V357, P570, DOI 10.1126/science.aam9949
   Castro-Barquero S, 2020, NUTRIENTS, V12, DOI 10.3390/nu12102983
   Chen F, 2018, INT J BIOL MACROMOL, V112, P211, DOI 10.1016/j.ijbiomac.2018.01.169
   Dehghani S, 2019, IRAN J BASIC MED SCI, V22, P460, DOI 10.22038/IJBMS.2019.31964.7678
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Fu X, 2020, DIGESTION, V101, P659, DOI 10.1159/000493424
   Gevers D, 2014, CELL HOST MICROBE, V15, P382, DOI 10.1016/j.chom.2014.02.005
   Haro C, 2016, J NUTR BIOCHEM, V27, P27, DOI 10.1016/j.jnutbio.2015.08.011
   Hiel S, 2020, CLIN NUTR, V39, P3618, DOI 10.1016/j.clnu.2020.04.005
   Hooda S, 2012, J NUTR, V142, P1259, DOI 10.3945/jn.112.158766
   Jiang J, 2014, INT J BIOL MACROMOL, V67, P323, DOI 10.1016/j.ijbiomac.2014.03.030
   Jie ZY, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-00900-1
   Jones RB, 2019, GUT MICROBES, V10, P712, DOI 10.1080/19490976.2019.1592420
   Kakiyama G, 2013, J HEPATOL, V58, P949, DOI 10.1016/j.jhep.2013.01.003
   Label O, 2018, MBIO, V9, P1
   Mardinoglu A, 2018, CELL METAB, V27, P559, DOI 10.1016/j.cmet.2018.01.005
   Mazidi M, 2016, DIABETES METAB SYND, V10, pS150, DOI 10.1016/j.dsx.2016.01.024
   Min Y, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-10440-5
   Morrison DJ, 2016, GUT MICROBES, V7, P189, DOI 10.1080/19490976.2015.1134082
   O'Connor S, 2017, MATURITAS, V104, P11, DOI 10.1016/j.maturitas.2017.07.005
   Pedersen C, 2016, BRIT J NUTR, V116, P1869, DOI 10.1017/S0007114516004086
   Rodriguez J, 2020, GUT, V69, P1975, DOI 10.1136/gutjnl-2019-319726
   Ryan D, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-17348-5
   Shuai ML, 2021, EBIOMEDICINE, V66, DOI 10.1016/j.ebiom.2021.103284
   Tran TTT, 2019, MICROBIOME, V7, DOI 10.1186/s40168-019-0654-1
   Uauy R, 2009, BRIT J NUTR, V101, pS1, DOI 10.1017/S0007114509990511
   Wutthi-in M, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-67078-3
   Zeng Q, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-49462-w
   Zhang HY, 2021, BIOMED PHARMACOTHER, V133, DOI 10.1016/j.biopha.2020.110857
   Zhang X, 2015, SCI REP-UK, V5, DOI 10.1038/srep14405
   Zhang YF, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-18414-8
   Zhao X, 2021, PHARMACOL RES, V163, DOI 10.1016/j.phrs.2020.105362
   Zheng B, 2020, CARBOHYD POLYM, V246, DOI 10.1016/j.carbpol.2020.116637
NR 36
TC 0
Z9 0
U1 1
U2 3
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 0962-9351
EI 1466-1861
J9 MEDIAT INFLAMM
JI Mediat. Inflamm.
PD MAY 19
PY 2022
VL 2022
AR 2078520
DI 10.1155/2022/2078520
PG 9
WC Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Immunology
GA 1U0PY
UT WOS:000805124300001
PM 35633654
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Ropot, AV
   Karamzin, AM
   Sergeyev, OV
AF Ropot, Anastasiia V.
   Karamzin, Andrei M.
   Sergeyev, Oleg V.
TI Cultivation of the Next-Generation Probiotic Akkermansia muciniphila,
   Methods of Its Safe Delivery to the Intestine, and Factors Contributing
   to Its Growth In Vivo
SO CURRENT MICROBIOLOGY
LA English
DT Review
ID GUT MICROBIOTA; POLYPHENOLS; MUCIN; MECHANISMS; METFORMIN; SURVIVAL;
   OBESITY; COLON; MICE; 4-EPIMERASE
AB Probiotics are widely used for treatment of various human diseases, and their spectrum is not limited by intestinal diseases only. That is why there is a growing interest in the development of new probiotics that can modify intestinal microbiome in accordance with the needs for treatment. In 2004, Akkermansia muciniphila was discovered, and later it was shown to prevent the development of metabolic syndrome and diabetes mellitus in mice. Nevertheless, before using it for treatment, conditions necessary for its growth need to be identified. In particular, certain carbohydrates, including amino sugars, such as N-acetylglucosamine and N-acetylgalactosamine, were discovered to be necessary for successful cultivation of A. muciniphila in vitro. This is not surprising, since the natural habitat of A. muciniphila is intestinal mucin, which contains different amino sugars. Besides, ways of A. muciniphila protection from harmful factors on the way to the intestine have been developed. In addition, prebiotics such as oligosaccharides, polyphenols, as well as metformin used for diabetes mellitus treatment can promote its growth in the intestine. Finally, there is the first evidence of A. muciniphila administration to humans, which confirms the safety of its use and describes positive metabolic effects. Overall, these data suggest the possibility of an early introduction of this next-generation probiotic into clinical practice.
C1 [Ropot, Anastasiia V.; Karamzin, Andrei M.; Sergeyev, Oleg V.] IM Sechenov First Moscow State Med Univ Sechenov, Trubetskaya St 8, Moscow, Russia.
C3 Sechenov First Moscow State Medical University
RP Ropot, AV (通讯作者)，IM Sechenov First Moscow State Med Univ Sechenov, Trubetskaya St 8, Moscow, Russia.
EM ropot_a_v@student.sechenov.ru
RI Karamzin, Andrei/AAD-6506-2020
OI Karamzin, Andrei/0000-0002-1911-5954; Ropot,
   Anastasiia/0000-0002-6939-7558; Sergeyev, Oleg/0000-0003-3407-2224
CR Allin KH, 2015, EUR J ENDOCRINOL, V172, pR167, DOI 10.1530/EJE-14-0874
   Bailey CJ, 2008, DIABETOLOGIA, V51, P1552, DOI 10.1007/s00125-008-1053-5
   Barreteau H, 2008, FEMS MICROBIOL REV, V32, P168, DOI 10.1111/j.1574-6976.2008.00104.x
   Bernatchez S, 2005, J BIOL CHEM, V280, P4792, DOI 10.1074/jbc.M407767200
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   Chen M, 2012, FOOD MICROBIOL, V30, P68, DOI 10.1016/j.fm.2011.10.017
   Choy YY, 2013, J AGR FOOD CHEM, V61, P121, DOI 10.1021/jf301939e
   Daglia M, 2012, CURR OPIN BIOTECH, V23, P174, DOI 10.1016/j.copbio.2011.08.007
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Depommier C, 2019, NAT MED, V25, P1096, DOI 10.1038/s41591-019-0495-2
   Derrien M, 2004, INT J SYST EVOL MICR, V54, P1469, DOI 10.1099/ijs.0.02873-0
   Derrien M, 2008, APPL ENVIRON MICROB, V74, P1646, DOI 10.1128/AEM.01226-07
   Derrien M, 2017, MICROB PATHOGENESIS, V106, P171, DOI 10.1016/j.micpath.2016.02.005
   Durand P, 2008, ARCH BIOCHEM BIOPHYS, V474, P302, DOI 10.1016/j.abb.2008.01.026
   El Gharras H, 2009, INT J FOOD SCI TECH, V44, P2512, DOI 10.1111/j.1365-2621.2009.02077.x
   El Hage R, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.01889
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Everard A, 2011, DIABETES, V60, P2775, DOI 10.2337/db11-0227
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Gao B, 2017, ENVIRON HEALTH PERSP, V125, P198, DOI 10.1289/EHP202
   Geurts L, 2014, BENEF MICROBES, V5, P3, DOI 10.3920/BM2012.0065
   Gibson GR, 2017, NAT REV GASTRO HEPAT, V14, P491, DOI 10.1038/nrgastro.2017.75
   Hartstra AV, 2015, DIABETES CARE, V38, P159, DOI 10.2337/dc14-0769
   Johansson MEV, 2011, P NATL ACAD SCI USA, V108, P4659, DOI 10.1073/pnas.1006451107
   KADNER RJ, 1992, J GEN MICROBIOL, V138, P2007, DOI 10.1099/00221287-138-10-2007
   Lalicic-Petronijevic J, 2015, J FUNCT FOODS, V15, P541, DOI 10.1016/j.jff.2015.03.046
   Liang ZC, 2012, J AGR FOOD CHEM, V60, P1291, DOI 10.1021/jf2046637
   Lu K, 2014, ENVIRON HEALTH PERSP, V122, P284, DOI 10.1289/ehp.1307429
   Marchesi JR, 2016, GUT, V65, P330, DOI 10.1136/gutjnl-2015-309990
   Marcial-Coba MS, 2019, FEMS MICROBIOL LETT, V366, DOI 10.1093/femsle/fny290
   Marcial-Coba MS, 2018, FOOD FUNCT, V9, P5868, DOI [10.1039/C8FO01331D, 10.1039/c8fo01331d]
   Masumoto S, 2016, SCI REP-UK, V6, DOI 10.1038/srep31208
   McDole JR, 2012, NATURE, V483, P345, DOI 10.1038/nature10863
   Morgan CA, 2006, J MICROBIOL METH, V66, P183, DOI 10.1016/j.mimet.2006.02.017
   Ottman N, 2017, BEST PRACT RES CL GA, V31, P637, DOI 10.1016/j.bpg.2017.10.001
   Ottman N, 2017, APPL ENVIRON MICROB, V83, DOI 10.1128/AEM.01014-17
   Pernicova I, 2014, NAT REV ENDOCRINOL, V10, P143, DOI 10.1038/nrendo.2013.256
   Plovier H, 2017, NAT MED, V23, P107, DOI 10.1038/nm.4236
   Possemiers S, 2010, INT J FOOD MICROBIOL, V141, P97, DOI 10.1016/j.ijfoodmicro.2010.03.008
   Roopchand DE, 2015, DIABETES, V64, P2847, DOI 10.2337/db14-1916
   Roopchand DE, 2013, J AGR FOOD CHEM, V61, P11428, DOI 10.1021/jf403238e
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Sinclair EM, 2005, PHYSIOLOGY, V20, P357, DOI 10.1152/physiol.00030.2005
   Tanaka T, 2005, J BACTERIOL, V187, P7038, DOI 10.1128/JB.187.20.7038-7044.2005
   Thoden JB, 2001, J BIOL CHEM, V276, P15131, DOI 10.1074/jbc.M100220200
   Thomsson KA, 2012, GLYCOBIOLOGY, V22, P1128, DOI 10.1093/glycob/cws083
   Tripathi MK, 2014, J FUNCT FOODS, V9, P225, DOI 10.1016/j.jff.2014.04.030
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   van der Ark KCH, 2018, MICROB BIOTECHNOL, V11, P476, DOI 10.1111/1751-7915.13033
   van der Ark KCH, 2017, FOOD RES INT, V102, P372, DOI 10.1016/j.foodres.2017.09.004
   van Passel MWJ, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0016876
   Wang HS, 2018, FOOD FUNCT, V9, P3916, DOI 10.1039/c8fo00209f
   WU HC, 1971, J BACTERIOL, V105, P455, DOI 10.1128/JB.105.2.455-466.1971
   Xu YP, 2011, J AGR FOOD CHEM, V59, P10586, DOI 10.1021/jf202438d
   Yoshida K, 2002, J LIPID RES, V43, P1770, DOI 10.1194/jlr.C200010-JLR200
   YUI T, 1992, CARBOHYD RES, V229, P41, DOI 10.1016/S0008-6215(00)90479-8
NR 56
TC 9
Z9 11
U1 4
U2 52
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0343-8651
EI 1432-0991
J9 CURR MICROBIOL
JI Curr. Microbiol.
PD AUG
PY 2020
VL 77
IS 8
BP 1363
EP 1372
DI 10.1007/s00284-020-01992-7
EA APR 2020
PG 10
WC Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology
GA MF1PB
UT WOS:000528088300001
PM 32318863
DA 2023-06-08
ER

PT S
AU Rowan, S
   Taylor, A
AF Rowan, Sheldon
   Taylor, Allen
BE Ash, JD
   Anderson, RE
   LaVail, MM
   Rickman, CB
   Hollyfield, JG
   Grimm, C
TI The Role of Microbiota in Retinal Disease
SO RETINAL DEGENERATIVE DISEASES: MECHANISMS AND EXPERIMENTAL THERAPY
SE Advances in Experimental Medicine and Biology
LA English
DT Article; Proceedings Paper
CT 17th International Symposium on Retinal Degeneration (RD)
CY SEP 19-24, 2016
CL Kyoto, JAPAN
SP Fdn Fighting Blindness, BrightFocus Fdn, Pro Retina, Fritz Tobler Fdn, Harrington Discovery Inst
DE Gut microbiome; Oral microbiome; Microbiota; Gut dysbiosis; Age-related
   macular degeneration; Diabetic retinopathy; Glaucoma; Uveitis; Glycemic
   index; Gut-retina axis
ID HELICOBACTER-PYLORI INFECTION; GUT MICROBIOTA; OPEN-ANGLE; METFORMIN;
   PATHOGENESIS; ASSOCIATION; METAGENOME; GLAUCOMA; HEALTH; IMPACT
AB The ten years since the first publications on the human microbiome project have brought enormous attention and insight into the role of the human microbiome in health and disease. Connections between populations of microbiota and ocular disease are now being established, and increased accessibility to microbiome research and insights into other diseases is expected to yield enormous information in the coming years. With the characterization of the ocular microbiome, important insights have already been made regarding corneal and conjunctival tissues. Roles for non-ocular microbiomes in complex retinal diseases are now being evaluated. For example, the gut microbiome has been implicated in the pathogenesis of uveitis. This short review will summarize the few studies linking gut or oral microbiota to diabetic retinopathy (DR), glaucoma, and age-related macular degeneration (AMD). We will also conjecture where the most significant findings still remain to be elucidated. Finally, we will propose the gut-retina axis, related but distinct from the gut-brain axis.
C1 [Rowan, Sheldon; Taylor, Allen] Tufts Univ, USDA, JM Human Nutr Res Ctr Aging HNRCA, Boston, MA 02111 USA.
   [Rowan, Sheldon; Taylor, Allen] Tufts Univ, Sch Med, Dept Ophthalmol, Boston, MA 02111 USA.
   [Taylor, Allen] Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02111 USA.
C3 Tufts University; United States Department of Agriculture (USDA); Tufts
   University; Tufts University
RP Rowan, S (通讯作者)，Tufts Univ, USDA, JM Human Nutr Res Ctr Aging HNRCA, Boston, MA 02111 USA.; Rowan, S (通讯作者)，Tufts Univ, Sch Med, Dept Ophthalmol, Boston, MA 02111 USA.
EM sheldon.rowan@tufts.edu; Allen.taylor@tufts.edu
RI Rowan, Sheldon/AAA-3271-2019
OI Rowan, Sheldon/0000-0002-1123-6743
CR Allin KH, 2015, EUR J ENDOCRINOL, V172, pR167, DOI 10.1530/EJE-14-0874
   Arora T, 2016, J INTERN MED, V280, P339, DOI 10.1111/joim.12508
   Astafurov K, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0104416
   Clemente JC, 2012, CELL, V148, P1258, DOI 10.1016/j.cell.2012.01.035
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Ghaisas S, 2016, PHARMACOL THERAPEUT, V158, P52, DOI 10.1016/j.pharmthera.2015.11.012
   Horai R, 2015, IMMUNITY, V43, P343, DOI 10.1016/j.immuni.2015.07.014
   Kaarniranta K, 2011, J ALZHEIMERS DIS, V24, P615, DOI 10.3233/JAD-2011-101908
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kim JM, 2011, INVEST OPHTH VIS SCI, V52, P665, DOI 10.1167/iovs.10-6096
   Kountouras J, 2003, GRAEF ARCH CLIN EXP, V241, P884, DOI 10.1007/s00417-003-0779-5
   Kugadas Abirami, 2016, Ocul Surf, V14, P342, DOI 10.1016/j.jtos.2016.04.004
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Lu Louise J., 2016, Yale Journal of Biology and Medicine, V89, P325
   Mayer EA, 2015, J CLIN INVEST, V125, P926, DOI 10.1172/JCI76304
   McCreight LJ, 2016, DIABETOLOGIA, V59, P426, DOI 10.1007/s00125-015-3844-9
   Munie M, 2014, INVEST OPHTH VIS SCI, V55
   Nakamura YK, 2016, INVEST OPHTH VIS SCI, V57, P3747, DOI 10.1167/iovs.16-19733
   Neu Josef, 2013, Curr Pediatr Rep, V1, P215
   O'Mahony SM, 2015, BEHAV BRAIN RES, V277, P32, DOI 10.1016/j.bbr.2014.07.027
   Oresic M, 2009, EXP EYE RES, V89, P604, DOI 10.1016/j.exer.2009.06.018
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Rosenbaum JT, 2016, JPN J OPHTHALMOL, V60, P1, DOI 10.1007/s10384-015-0416-y
   Sacca SC, 2014, MEDICINE, V93, DOI 10.1097/MD.0000000000000216
   Uchiki T, 2012, AGING CELL, V11, P1, DOI 10.1111/j.1474-9726.2011.00752.x
   Weikel KA, 2012, MOL ASPECTS MED, V33, P318, DOI 10.1016/j.mam.2012.03.005
   Weikel KA, 2012, INVEST OPHTH VIS SCI, V53, P622, DOI 10.1167/iovs.11-8545
   Yang C, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0133021
   Yi QY, 2016, AM J TRANSL RES, V8, P3947
   Zeng J, 2015, INVEST OPHTH VIS SCI, V56, P5238, DOI 10.1167/iovs.15-17059
   Zullo A, 2012, DIGEST LIVER DIS, V44, P627, DOI 10.1016/j.dld.2012.03.011
NR 31
TC 41
Z9 42
U1 5
U2 28
PU SPRINGER INTERNATIONAL PUBLISHING AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 0065-2598
EI 2214-8019
BN 978-3-319-75402-4; 978-3-319-75401-7
J9 ADV EXP MED BIOL
JI Adv.Exp.Med.Biol.
PY 2018
VL 1074
BP 429
EP 435
DI 10.1007/978-3-319-75402-4_53
PG 7
WC Cell Biology; Medicine, Research & Experimental; Ophthalmology
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Research & Experimental Medicine; Ophthalmology
GA BK8XP
UT WOS:000443968600054
PM 29721973
DA 2023-06-08
ER

PT J
AU El-Din, SHS
   Salem, MB
   El-Lakkany, NM
   Hammam, OA
   Nasr, SM
   Okasha, H
   Ahmed, LA
   Saleh, S
   Botros, SS
AF El-Din, Sayed H. Seif
   Salem, M. B.
   El-Lakkany, N. M.
   Hammam, O. A.
   Nasr, S. M.
   Okasha, H.
   Ahmed, L. A.
   Saleh, S.
   Botros, S. S.
TI Early intervention with probiotics and metformin alleviates liver injury
   in NAFLD rats via targeting gut microbiota dysbiosis and
   p-AKT/mTOR/LC-3II pathways
SO HUMAN & EXPERIMENTAL TOXICOLOGY
LA English
DT Article
DE Autophagy; dysbiosis; inflammation; Lactobacillus reuteri; NAFLD
ID INSULIN-RESISTANCE; DISEASE; OBESE; PCR; AUTOPHAGY; EPIDEMIOLOGY;
   MODULATION; BACTERIA; IMPROVES; GLUCOSE
AB Non-alcoholic fatty liver disease (NAFLD) constitutes a major health problem worldwide and intimately links with obesity and diabetes. This study aimed to explore the therapeutic impact of early treatment with metformin (MTF) alone or in combination with Lactobacillus reuteri DSM 17938 (L. reuteri) + metronidazole (MTZ) in male Sprague Dawley rats with high-fat diet (HFD)-induced NAFLD. Hepatic steatosis was induced by feeding rats HFD for 6 weeks. MTF (150 mg/kg/day) or L. reuteri (2 x 10(9) colony forming unit/day) were given orally for 4 weeks; meanwhile, MTZ (15 mg/kg/day, p.o.) was administered for 1 week. Administration of L. reuteri + MTZ in combination with MTF produced a superior effect concerning insulin resistance (IR), lipid profile, liver function, oxidative stress, inflammatory and autophagic markers than using each treatment alone. Besides, this combination resulted in disappearance of steatosis, inflammation and vacuolation within hepatic architecture. Moreover, it normalized short chain fatty acids (SCFAs) as well as Firmicutes and Bacteroidetes faecal contents. In conclusion, early treatment with L. reuteri + MTZ in combination with MTF could prevent NAFLD progression and liver injury through targeting gut dysbiosis, inflammation and autophagic pathways.
C1 [El-Din, Sayed H. Seif; Salem, M. B.; El-Lakkany, N. M.; Botros, S. S.] Theodor Bilharz Res Inst, Pharmacol Dept, Giza, Egypt.
   [Hammam, O. A.] Theodor Bilharz Res Inst, Pathol Dept, 1 El Nile St,Imbaba POB 30, Giza 12411, Egypt.
   [Nasr, S. M.; Okasha, H.] Theodor Bilharz Res Inst, Biochem Dept, Giza, Egypt.
   [Ahmed, L. A.; Saleh, S.] Cairo Univ, Fac Pharm, Pharmacol & Toxicol Dept, Cairo, Egypt.
C3 Egyptian Knowledge Bank (EKB); Theodor Bilharz Research Institute
   (TBRI); Egyptian Knowledge Bank (EKB); Theodor Bilharz Research
   Institute (TBRI); Egyptian Knowledge Bank (EKB); Theodor Bilharz
   Research Institute (TBRI); Egyptian Knowledge Bank (EKB); Cairo
   University
RP El-Din, SHS (通讯作者)，Theodor Bilharz Res Inst, Pathol Dept, 1 El Nile St,Imbaba POB 30, Giza 12411, Egypt.
EM s.seifeldin@tbri.gov.eg
RI Ahmed, Hend Okasha/AAI-3806-2020; Nasr, Sami/HZK-6433-2023; Seif el-Din,
   Sayed/I-6797-2015
OI Ahmed, Hend Okasha/0000-0003-1125-245X; Nasr, Sami/0000-0001-8683-3131;
   Seif el-Din, Sayed/0000-0002-0357-3467; Hammam,
   Olfat/0000-0002-4965-5804; Botros, Sanaa/0000-0002-4131-0983
FU Theodor Bilharz Research Institute [117/A]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This work
   is supported by the internal research project 117/A (PI: SH Seif el-Din)
   for basic and applied research, a grant from Theodor Bilharz Research
   Institute.
CR Ahmed LA, 2020, EUR J PHARMACOL, V887, DOI 10.1016/j.ejphar.2020.173461
   Alisi A, 2014, ALIMENT PHARM THER, V39, P1276, DOI 10.1111/apt.12758
   Allin KH, 2015, EUR J ENDOCRINOL, V172, pR167, DOI 10.1530/EJE-14-0874
   Aron-Wisnewsky J, 2020, NAT REV GASTRO HEPAT, V17, P279, DOI 10.1038/s41575-020-0269-9
   Boursier J, 2016, HEPATOLOGY, V63, P764, DOI 10.1002/hep.28356
   Brunkwall L, 2017, DIABETOLOGIA, V60, P943, DOI 10.1007/s00125-017-4278-3
   Buzzetti E, 2016, METABOLISM, V65, P1038, DOI 10.1016/j.metabol.2015.12.012
   Ceponis PJM, 2000, J BIOL CHEM, V275, P29132, DOI 10.1074/jbc.M003516200
   Chakaroun RM, 2020, NUTRIENTS, V12, DOI 10.3390/nu12041082
   Chalasani NP, 2017, HEPATOLOGY, V66, p303A
   Czaja MJ, 2016, DIGEST DIS SCI, V61, P1304, DOI 10.1007/s10620-015-4025-x
   Dahiya DK, 2017, J FOOD SCI TECH MYS, V54, P792, DOI 10.1007/s13197-017-2523-x
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Del Campo JA, 2018, WORLD J HEPATOL, V10, P1, DOI 10.4254/wjh.v10.i1.1
   Diehl AM, 2000, IMMUNOL REV, V174, P160, DOI 10.1034/j.1600-0528.2002.017411.x
   El-Lakkany NM, 2016, RES PHARM SCI, V11, P374, DOI 10.4103/1735-5362.192487
   ELLMAN GL, 1959, ARCH BIOCHEM BIOPHYS, V82, P70, DOI 10.1016/0003-9861(59)90090-6
   Finlayson A, 2015, WORLD J GASTRO ENDOS, V7, P1103, DOI [10.4253/wjge.v7.i13.1103, 10.4291/wjgp.v6.i4.110]
   Foretz M, 2010, J CLIN INVEST, V120, P2355, DOI 10.1172/JCI40671
   FREUND HR, 1985, J SURG RES, V38, P356, DOI 10.1016/0022-4804(85)90049-6
   Ganz M, 2013, HEPATOL INT, V7, pS771, DOI 10.1007/s12072-013-9468-6
   Goffredo M, 2016, J CLIN ENDOCR METAB, V101, P4367, DOI 10.1210/jc.2016-1797
   Gorbach SL, 2000, AM J GASTROENTEROL, V95, pS2, DOI 10.1016/S0002-9270(99)00806-0
   Guo X, 2008, LETT APPL MICROBIOL, V47, P367, DOI 10.1111/j.1472-765X.2008.02408.x
   Haak BW, 2019, J ANTIMICROB CHEMOTH, V74, P782, DOI 10.1093/jac/dky471
   Hsieh FC, 2013, NUTR METAB, V10, DOI 10.1186/1743-7075-10-35
   Jasirwan COM, 2019, BIOSCI MICROB FOOD H, V38, P81, DOI 10.12938/bmfh.18-032
   Kleiner DE, 2005, HEPATOLOGY, V41, P1313, DOI 10.1002/hep.20701
   Lau E, 2015, BIOMED RES INT, V2015, DOI 10.1155/2015/979515
   Layton A, 2006, APPL ENVIRON MICROB, V72, P4214, DOI 10.1128/AEM.01036-05
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Lee JH, 1999, INT J FOOD MICROBIOL, V50, P155, DOI 10.1016/S0168-1605(99)00086-0
   Lin HZ, 2000, NAT MED, V6, P998, DOI 10.1038/79697
   Livak KJ, 2001, METHODS, V25, P402, DOI 10.1006/meth.2001.1262
   LOWRY OH, 1951, J BIOL CHEM, V193, P265
   Masarone M, 2014, REV RECENT CLIN TRIA, V9, P126, DOI 10.2174/1574887109666141216111143
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Membrez M, 2008, FASEB J, V22, P2416, DOI 10.1096/fj.07-102723
   OHKAWA H, 1979, ANAL BIOCHEM, V95, P351, DOI 10.1016/0003-2697(79)90738-3
   Poutahidis T, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0068596
   Raman M, 2013, CLIN GASTROENTEROL H, V11, P868, DOI 10.1016/j.cgh.2013.02.015
   Rau M, 2018, UNITED EUR GASTROENT, V6, P1496, DOI 10.1177/2050640618804444
   Robinson C, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0103025
   Saltzman ET, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.00061
   Singh R, 2009, NATURE, V458, P1131, DOI 10.1038/nature07976
   Sobhonslidsuk A, 2018, BIOMED RES INT, V2018, DOI 10.1155/2018/9340316
   Sohail MU, 2017, J DIABETES RES, V2017, DOI 10.1155/2017/9631435
   Xiao J, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/642920
   Yadav H, 2013, J BIOL CHEM, V288, P25088, DOI 10.1074/jbc.M113.452516
   Yang YW, 2015, APPL ENVIRON MICROB, V81, P6749, DOI 10.1128/AEM.01906-15
   Younossi Z, 2018, NAT REV GASTRO HEPAT, V15, P11, DOI 10.1038/nrgastro.2017.109
   Younossi ZM, 2015, HEPATOLOGY, V62, p739A
NR 52
TC 8
Z9 8
U1 2
U2 20
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0960-3271
EI 1477-0903
J9 HUM EXP TOXICOL
JI Hum. Exp. Toxicol.
PD SEP
PY 2021
VL 40
IS 9
BP 1496
EP 1509
AR 0960327121999445
DI 10.1177/0960327121999445
EA MAR 2021
PG 14
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA UL2MY
UT WOS:000636023200001
PM 33678036
DA 2023-06-08
ER

PT J
AU Wei, SD
   Bahl, MI
   Baunwall, SMD
   Hvas, CL
   Licht, TR
AF Wei, Shaodong
   Bahl, Martin Iain
   Baunwall, Simon Mark Dahl
   Hvas, Christian Lodberg
   Licht, Tine Rask
TI Determining Gut Microbial Dysbiosis: a Review of Applied Indexes for
   Assessment of Intestinal Microbiota Imbalances
SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY
LA English
DT Review
DE dysbiosis; dysbiosis index; gut; imbalance; intestine; microbiome;
   microbiota
ID IRRITABLE-BOWEL-SYNDROME; METFORMIN; PROFILE
AB Assessing "dysbiosis" in intestinal microbial communities is increasingly considered a routine analysis in microbiota studies, and it has added relevant information to the prediction and characterization of diseases and other adverse conditions. However, dysbiosis is not a well-defined condition. A variety of different dysbiosis indexes have been suggested and applied, but their underlying methodologies, as well as the cohorts and conditions for which they have been developed, differ considerably. To date, no comprehensive overview and comparison of all the different methodologies and applications of such indexes is available. Here, we list all types of dysbiosis indexes identified in the literature, introduce their methodology, group them into categories, and discuss their potential descriptive and clinical applications as well as their limitations. Thus, our focus is not on the implications of dysbiosis for disease but on the methodological approaches available to determine and quantify this condition.
C1 [Wei, Shaodong; Bahl, Martin Iain; Licht, Tine Rask] Tech Univ Denmark, Natl Food Inst, Lyngby, Denmark.
   [Baunwall, Simon Mark Dahl; Hvas, Christian Lodberg] Aarhus Univ Hosp, Dept Hepatol & Gastroenterol, Aarhus, Denmark.
C3 Technical University of Denmark; Aarhus University
RP Licht, TR (通讯作者)，Tech Univ Denmark, Natl Food Inst, Lyngby, Denmark.
EM trli@food.dtu.dk
OI Mark Dahl Baunwall, Simon/0000-0002-5135-7435; Licht, Tine
   Rask/0000-0002-6399-9574; Bahl, Martin Iain/0000-0003-1579-8038
FU Innovation Fund Denmark [8056-00006B]
FX This study was carried out under the Centre for Fecal Microbiota
   Transplantation at Aarhus University Hospital (CEFTA), funded by the
   Innovation Fund Denmark (grant no. 8056-00006B).
CR Aasbrenn M, 2018, SCAND J CLIN LAB INV, V78, P109, DOI 10.1080/00365513.2017.1419372
   AlShawaqfeh MK, 2017, FEMS MICROBIOL ECOL, V93, DOI 10.1093/femsec/fix136
   Bajaj JS, 2014, J HEPATOL, V60, P940, DOI 10.1016/j.jhep.2013.12.019
   Bennet SMP, 2018, GUT, V67, P872, DOI 10.1136/gutjnl-2016-313128
   Blake AB, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0224454
   Brahe LK, 2015, BRIT J NUTR, V114, P406, DOI 10.1017/S0007114515001786
   Casen C, 2015, ALIMENT PHARM THER, V42, P71, DOI 10.1111/apt.13236
   Castaner O, 2018, INT J ENDOCRINOL, V2018, DOI 10.1155/2018/4095789
   Chaitman J, 2020, FRONT VET SCI, V7, DOI 10.3389/fvets.2020.00192
   Chen L, 2018, PEERJ, V6, DOI 10.7717/peerj.4600
   David LA, 2014, NATURE, V505, P559, DOI 10.1038/nature12820
   Desilets AR, 2008, ANN PHARMACOTHER, V42, P817, DOI 10.1345/aph.1K656
   El-Salhy M, 2020, GUT, V69, P859, DOI 10.1136/gutjnl-2019-319630
   El-Salhy M, 2019, NUTRIENTS, V11, DOI 10.3390/nu11061415
   Falony G, 2016, SCIENCE, V352, P560, DOI 10.1126/science.aad3503
   Farup PG, 2020, NUTRIENTS, V12, DOI 10.3390/nu12030802
   Farup PG, 2019, J OBES, V2019, DOI 10.1155/2019/4608315
   Farup Per G, 2018, BMC Obes, V5, P30, DOI 10.1186/s40608-018-0207-3
   Ferrannini E, 2014, NEW ENGL J MED, V371, P1547, DOI 10.1056/NEJMcibr1409796
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Franzosa EA, 2018, NAT METHODS, V15, P962, DOI 10.1038/s41592-018-0176-y
   Fujishiro MA, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0228145
   Gevers D, 2014, CELL HOST MICROBE, V15, P382, DOI 10.1016/j.chom.2014.02.005
   Guo Z, 2016, SCI REP-UK, V6, DOI 10.1038/srep20602
   Huang S, 2014, ISME J, V8, P1768, DOI 10.1038/ismej.2014.32
   Hustoft TN, 2017, NEUROGASTROENT MOTIL, V29, DOI 10.1111/nmo.12969
   Jeffery IB, 2012, GUT, V61, P997, DOI 10.1136/gutjnl-2011-301501
   Jorgensen SF, 2016, MUCOSAL IMMUNOL, V9, P1455, DOI 10.1038/mi.2016.18
   Khor B, 2011, NATURE, V474, P307, DOI 10.1038/nature10209
   Kim YJ, 2016, BMC MICROBIOL, V16, DOI 10.1186/s12866-016-0673-z
   Le Chatelier E, 2013, NATURE, V500, P541, DOI 10.1038/nature12506
   Levy M, 2017, NAT REV IMMUNOL, V17, P219, DOI 10.1038/nri.2017.7
   Ley RE, 2006, NATURE, V444, P1022, DOI 10.1038/4441022a
   Litvak Y, 2017, CURR OPIN MICROBIOL, V39, P1, DOI 10.1016/j.mib.2017.07.003
   Liu Y, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.00470
   Lloyd-Price J, 2019, NATURE, V569, P655, DOI 10.1038/s41586-019-1237-9
   Magnusson MK, 2016, J CROHNS COLITIS, V10, P943, DOI 10.1093/ecco-jcc/jjw051
   Mandl T, 2017, ARTHRITIS RES THER, V19, DOI 10.1186/s13075-017-1446-2
   Manichanh C, 2012, NAT REV GASTRO HEPAT, V9, P599, DOI 10.1038/nrgastro.2012.152
   Mayerhofer CCK, 2020, ESC HEART FAIL, V7, P456, DOI 10.1002/ehf2.12596
   Mazzawi T, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0194904
   Montassier E, 2018, MICROBIOME, V6, DOI 10.1186/s40168-018-0514-4
   Nakatsu G, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms9727
   Olesen SW, 2016, NAT MICROBIOL, V1, DOI [10.1038/NMICROBIOL.2016.228, 10.1038/nmicrobiol.2016.228]
   Qi YJ, 2012, ENSEMBLE MACHINE LEARNING: METHODS AND APPLICATIONS, P307, DOI 10.1007/978-1-4419-9326-7_11
   Rossi G, 2020, VET SCI, V7, DOI 10.3390/vetsci7010021
   Saffouri GB, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-09964-7
   Santiago M, 2019, AIMS MICROBIOL, V5, P1, DOI 10.3934/microbiol.2019.1.1
   Sarangi AN, 2019, J CLIN EXP HEPATOL, V9, P62, DOI 10.1016/j.jceh.2018.04.016
   Schmidt M, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0201279
   Shen Y, 2018, SCHIZOPHR RES, V197, P470, DOI 10.1016/j.schres.2018.01.002
   Soares RC, 2016, FRONT CELL INFECT MI, V6, DOI 10.3389/fcimb.2016.00157
   Sokol H, 2017, GUT, V66, P1039, DOI [10.1136/gutjnl-2015-310746, 10.1136/gutjnl-20]
   Suez J, 2014, NATURE, V514, P181, DOI 10.1038/nature13793
   Sze MA, 2016, MBIO, V7, DOI 10.1128/mBio.01018-16
   Thorsen J, 2016, MICROBIOME, V4, DOI 10.1186/s40168-016-0208-8
   Truong DT, 2015, NAT METHODS, V12, P902, DOI 10.1038/nmeth.3589
   Tysnes KR, 2020, ANIMALS-BASEL, V10, DOI 10.3390/ani10020204
   Valeur J, 2018, DIGEST DIS SCI, V63, P429, DOI 10.1007/s10620-017-4893-3
   Vila AV, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-019-14177-z
   Wang J, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.02222
   Whittemore JC, 2019, GUT MICROBES, V10, P521, DOI 10.1080/19490976.2018.1560754
   Xia GH, 2019, FRONT NEUROL, V10, DOI 10.3389/fneur.2019.00397
NR 63
TC 22
Z9 22
U1 7
U2 17
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0099-2240
EI 1098-5336
J9 APPL ENVIRON MICROB
JI Appl. Environ. Microbiol.
PD JUN
PY 2021
VL 87
IS 11
AR e00395-21
DI 10.1128/AEM.00395-21
PG 13
WC Biotechnology & Applied Microbiology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Microbiology
GA SK0KO
UT WOS:000655912400015
PM 33741632
OA hybrid, Green Published
DA 2023-06-08
ER

PT J
AU Hussain, N
   Naeem, M
   Pinato, DJ
AF Hussain, Nadiya
   Naeem, Muntaha
   Pinato, David J.
TI Concomitant medications and immune checkpoint inhibitor therapy for
   cancer: causation or association?
SO HUMAN VACCINES & IMMUNOTHERAPEUTICS
LA English
DT Article
DE antibiotics; corticosteroids; proton pump inhibitors; opioids;
   metformin; cancer immunotherapy; immune checkpoint inhibitors
ID PROTON PUMP INHIBITORS; GUT MICROBIOTA; EFFICACY; RISK
AB The majority of cancer patients assume concomitant medications for the treatment of cancer-related symptoms or co-morbidities. As immune checkpoint inhibitors expand in the treatment of a widening range of malignancies, drug-drug interactions have become an area of increasing interest due to the potential for some concomitant medications to exert immune-modulatory effects and influence outcomes from immunotherapy. Here, we review the evidence supporting this association across selected drug classes including antibiotics, proton pump inhibitors, metformin, and opioids.
C1 [Hussain, Nadiya; Naeem, Muntaha; Pinato, David J.] Imperial Coll London, Hammersmith Hosp, Dept Surg & Canc, London, England.
C3 Imperial College London
RP Pinato, DJ (通讯作者)，Imperial Ctr Translat & Expt Med ICTEM, Dept Surg & Canc, 72 Du Cane Rd, London W12 0NN, England.
EM david.pinato@imperial.ac.uk
RI Pinato, David James/ABB-3719-2020
OI Pinato, David James/0000-0002-3529-0103; Naeem,
   Muntaha/0000-0001-5279-8331
FU Wellcome Trust Strategic Fund [PS3416]
FX DJP is supported by grant funding from the Wellcome Trust Strategic Fund
   [PS3416].
CR Abid MB, 2019, J IMMUNOTHER CANCER, V7, DOI 10.1186/s40425-019-0561-9
   Abu-Sbeih H, 2020, J CLIN ONCOL, V38, P576, DOI 10.1200/JCO.19.01674
   Acharya C, 2017, ALIMENT PHARM THER, V45, P319, DOI [10.1111/apt.13858, 10.1111/apt.14585]
   Afzal MZ, 2019, LUNG CANCER MANAG, V8, DOI 10.2217/lmt-2018-0016
   Afzal MZ, 2018, J IMMUNOTHER CANCER, V6, DOI 10.1186/s40425-018-0375-1
   Ahmed J, 2018, ONCOIMMUNOLOGY, V7, DOI 10.1080/2162402X.2018.1507670
   Arbour KC, 2018, J CLIN ONCOL, V36, P2872, DOI 10.1200/JCO.2018.79.0006
   Banerjee S, 2016, MUCOSAL IMMUNOL, V9, P1418, DOI 10.1038/mi.2016.9
   Beijnen JH, 2004, LANCET ONCOL, V5, P489, DOI 10.1016/S1470-2045(04)01528-1
   Biswas S, 2012, BMC MED, V10, DOI 10.1186/1741-7015-10-57
   Bruno G, 2019, WORLD J GASTROENTERO, V25, P2706, DOI 10.3748/wjg.v25.i22.2706
   Calic Z, 2018, J HEADACHE PAIN, V19
   Chalabi M, 2020, ANN ONCOL, V31, P525, DOI [10.1016/j.annonc.2020.01.006, 10.1016/j.annoc.2020.01.006]
   Chen DS, 2013, IMMUNITY, V39, P1, DOI 10.1016/j.immuni.2013.07.012
   Coutinho AE, 2011, MOL CELL ENDOCRINOL, V335, P2, DOI 10.1016/j.mce.2010.04.005
   Das S, 2019, J IMMUNOTHER CANCER, V7, DOI 10.1186/s40425-019-0805-8
   Derosa L, 2018, ANN ONCOL, V29, P1437, DOI 10.1093/annonc/mdy103
   Elkrief A, 2019, ONCOIMMUNOLOGY, V8, DOI 10.1080/2162402X.2019.1568812
   Fessas P, 2020, IMMUNOLOGY, V159, P167, DOI 10.1111/imm.13141
   Francino MP, 2016, FRONT MICROBIOL, V6, DOI 10.3389/fmicb.2015.01543
   Fuca G, 2019, ESMO OPEN, V4, DOI 10.1136/esmoopen-2018-000457
   Giles AJ, 2018, J IMMUNOTHER CANCER, V6, DOI 10.1186/s40425-018-0371-5
   Gong J, 2019, CLIN TRANSL MED, V8, DOI 10.1186/s40169-019-0225-x
   Gopalakrishnan V, 2018, SCIENCE, V359, P97, DOI 10.1126/science.aan4236
   Hodi FS, 2010, NEW ENGL J MED, V363, P711, DOI 10.1056/NEJMoa1003466
   Homicsko K, 2018, ANN ONCOL, V29, DOI [10.1093/annonc/mdy511.001, DOI 10.1093/ANNONC/MDY511.001]
   Iglesias-Santamaria A, 2020, CLIN TRANSL ONCOL, V22, P1481, DOI 10.1007/s12094-019-02282-w
   Jackson MA, 2016, GUT, V65, P749, DOI 10.1136/gutjnl-2015-310861
   Johnson DB, 2017, CANCER-AM CANCER SOC, V123, P1904, DOI 10.1002/cncr.30642
   Kamath Amrita V, 2016, Drug Discov Today Technol, V21-22, P75, DOI 10.1016/j.ddtec.2016.09.004
   Ketwaroo Gyanprakash A, 2013, Curr Gastroenterol Rep, V15, P344, DOI 10.1007/s11894-013-0344-2
   Kim H, 2019, BMC CANCER, V19, DOI 10.1186/s12885-019-6267-z
   Kluger HM, 2020, J IMMUNOTHER CANCER, V8, DOI 10.1136/jitc-2019-000398
   Kruger S, 2019, J EXP CLIN CANC RES, V38, DOI 10.1186/s13046-019-1266-0
   Kubo T, 2018, CLIN LUNG CANCER, V19, pE861, DOI 10.1016/j.cllc.2018.07.010
   Lagier JC, 2012, FRONT CELL INFECT MI, V2, DOI 10.3389/fcimb.2012.00136
   Leslie M, 2018, CANCER DISCOV, V8, P668, DOI 10.1158/2159-8290.CD-NB2018-048
   Lugini L, 2016, J ENZYM INHIB MED CH, V31, P538, DOI 10.3109/14756366.2015.1046062
   Luo Y, 2016, FRONT IMMUNOL, V7, DOI 10.3389/fimmu.2016.00604
   Medina P, 2020, J PHARM PRACT, V33, P338, DOI 10.1177/0897190019885230
   Mora AL, 2012, AM J MED SCI, V343, P277, DOI 10.1097/MAJ.0b013e31822f42eb
   Mukherjee S, 2019, J ONCOL PHARM PRACT, V25, P762, DOI 10.1177/1078155218771152
   Myers G, 2018, CURR ONCOL, V25, P342, DOI 10.3747/co.25.4235
   Ne S, 2016, CANCER IMMUNOL RES, V5, DOI [10.1158/2326-6066.CIR-16-0103, DOI 10.1158/2326-6066.CIR-16-0103]
   Oliveras-Ferraros C, 2012, CELL CYCLE, V11, P865, DOI 10.4161/cc.11.5.19252
   Patel SP, 2015, MOL CANCER THER, V14, P847, DOI 10.1158/1535-7163.MCT-14-0983
   Pinato DJ, 2019, J IMMUNOTHER CANCER, V7, DOI 10.1186/s40425-019-0775-x
   Pinato DJ, 2019, JAMA ONCOL, V5, P1774, DOI 10.1001/jamaoncol.2019.2785
   Nguyen QP, 2019, ANN ONCOL, V30, P115, DOI 10.1093/annonc/mdz338.107
   Ren MH, 2020, BEHAV PHARMACOL, V31, P113, DOI 10.1097/FBP.0000000000000538
   Ricciuti B, 2019, J CLIN ONCOL, V37, P1927, DOI 10.1200/JCO.19.00189
   Routy B, 2018, NAT REV CLIN ONCOL, V15, P382, DOI 10.1038/s41571-018-0006-2
   Schett A, 2020, CANCER CHEMOTH PHARM, V85, P121, DOI 10.1007/s00280-019-03993-1
   Schmidt C, 2017, NATURE, V552, P567, DOI 10.1038/d41586-017-08702-7
   Scott SC, 2018, J THORAC ONCOL, V13, P1771, DOI 10.1016/j.jtho.2018.06.004
   Seethapathy H, 2019, CLIN J AM SOC NEPHRO, V14, P1692, DOI 10.2215/CJN.00990119
   Svaton M, 2020, ANTICANCER RES, V40, P2209, DOI 10.21873/anticanres.14182
   Tinsley N, 2020, ONCOLOGIST, V25, P55, DOI 10.1634/theoncologist.2019-0160
   Trabolsi A, 2019, J CLIN ONCOL, V37, DOI 10.1200/JCO.2019.37.15_suppl.e14092
   Verdura S, 2019, ONCOIMMUNOLOGY, V8, DOI 10.1080/2162402X.2019.1633235
   Wheaton WW, 2014, ELIFE, V3, DOI 10.7554/eLife.02242
   Zhao S, 2019, LUNG CANCER, V130, P10, DOI 10.1016/j.lungcan.2019.01.017
   Zhou HH, 2011, ANNU REV PHARMACOL, V51, P359, DOI 10.1146/annurev-pharmtox-010510-100510
NR 63
TC 33
Z9 35
U1 0
U2 7
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 2164-5515
EI 2164-554X
J9 HUM VACC IMMUNOTHER
JI Human Vaccines Immunother.
PD JAN 2
PY 2021
VL 17
IS 1
BP 55
EP 61
DI 10.1080/21645515.2020.1769398
EA JUN 2020
PG 7
WC Biotechnology & Applied Microbiology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Immunology
GA QB5WC
UT WOS:000547331900001
PM 32574106
OA Green Published, Bronze
DA 2023-06-08
ER

PT J
AU Wang, DM
   Pham, VT
   Steinert, RE
   Zhernakova, A
   Fu, JY
AF Wang, Daoming
   Pham, Van T.
   Steinert, Robert E.
   Zhernakova, Alexandra
   Fu, Jingyuan
TI Microbial vitamin production mediates dietary effects on diabetic risk
SO GUT MICROBES
LA English
DT Article
DE Human gut microbiome; vitamin metabolism; cardiometabolic health;
   diabetes; exposures; fruit intake
ID GUT MICROBIOTA; METFORMIN; ASSOCIATION; RIBOFLAVIN; DEFICIENCY;
   INHIBITOR; IMPACT
AB Adequate levels of essential vitamins are important for the prevention of diabetes. While the main efforts to address this are currently focused on the intake of vitamin supplements, improving and maintaining intrinsic vitamin production capacity, which is determined by gut microbes, has received insufficient attention. In this study, we systematically investigated the relationship between gut microbial vitamin production and factors related to diabetes and cardiometabolic health in a deeply phenotyped cohort, Lifelines-DEEP (N = 1,135). We found that blood glucose-related factors, lipids, circulating inflammation, and fecal short-chain fatty acids are associated with gut microbial vitamin production. Use of laxatives and metformin are associated with increased levels of vitamin B1/B6 biosynthesis pathways. We further reveal a mediatory role for microbial vitamin B1/B2 production on the influence of fruit intake on diabetes risk. This study provides preliminary evidence for microbiome-targeted vitamin metabolism interventions to promote health.
C1 [Wang, Daoming; Zhernakova, Alexandra; Fu, Jingyuan] Univ Groningen, Univ Med Ctr Groningen, Dept Genet, NL-9713 AV Groningen, Netherlands.
   [Wang, Daoming; Fu, Jingyuan] Univ Groningen, Univ Med Ctr Groningen, Dept Pediat, NL-9713 AV Groningen, Netherlands.
   [Pham, Van T.; Steinert, Robert E.] DSM Nutr Prod Ltd, Global R&D Ctr Human Nutr & Care HNC, Basel, Switzerland.
   [Steinert, Robert E.] Univ Hosp Zurich, Dept Surg, Div Visceral & Transplantat Surg, Zurich, Switzerland.
   [Fu, Jingyuan] Univ Groningen, Univ Med Ctr Groningen, Dept Genet, NL-9713 AV Groningen, Netherlands.
   [Fu, Jingyuan] Univ Groningen, Univ Med Ctr Groningen, Dept Pediat, NL-9713 AV Groningen, Netherlands.
C3 University of Groningen; University of Groningen; DSM NV; University of
   Zurich; University Zurich Hospital; University of Groningen; University
   of Groningen
RP Fu, JY (通讯作者)，Univ Groningen, Univ Med Ctr Groningen, Dept Genet, NL-9713 AV Groningen, Netherlands.; Fu, JY (通讯作者)，Univ Groningen, Univ Med Ctr Groningen, Dept Pediat, NL-9713 AV Groningen, Netherlands.
EM j.fu@umcg.nl
RI Wang, Daoming/CAI-2445-2022; Steinert, Robert E/A-7770-2011
OI Wang, Daoming/0000-0003-4623-8527; Fu, Jingyuan/0000-0001-5578-1236
FU Dutch Heart Foundation IN-CONTROL; ERC Consolidator grant [CVON2018-27];
   NWO-VICI grant [101001678]; Netherlands Organ-on-Chip Initiative
   [VI.C.202.022, 715772]; NWO Gravitation project - Ministry of Education,
   Culture and Science of the government of The Netherlands; ERC Starting
   Grant [016.178.056]; NWO Gravitation grant Exposome-NL [024.003.001]; 
   [024.004.017]
FX J.F. is supported by the Dutch Heart Foundation IN-CONTROL
   (CVON2018-27), the ERC Consolidator grant (grant agreement No.
   101001678), NWO-VICI grant VI.C.202.022, and the Netherlands
   Organ-on-Chip Initiative, an NWO Gravitation project (024.003.001)
   funded by the Ministry of Education, Culture and Science of the
   government of The Netherlands. A.Z. is supported by the Dutch Heart
   Foundation IN-CONTROL (CVON2018-27), the ERC Starting Grant 715772,
   NWO-VIDI grant 016.178.056, and the NWO Gravitation grant Exposome-NL
   (024.004.017).
CR Barra NG, 2021, J ENDOCRINOL, V250, pR1, DOI 10.1530/JOE-21-0081
   Belda E, 2022, GUT, V71, P2463, DOI 10.1136/gutjnl-2021-325753
   Bolger AM, 2014, BIOINFORMATICS, V30, P2114, DOI 10.1093/bioinformatics/btu170
   Bolte LA, 2021, GUT, V70, P1287, DOI 10.1136/gutjnl-2020-322670
   Chen LM, 2022, NAT MED, V28, P2333, DOI 10.1038/s41591-022-02014-8
   Chen XT, 2021, DIABETES CARE, V44, P217, DOI 10.2337/dc20-1607
   da Silva RP, 2014, BIOFACTORS, V40, P277, DOI 10.1002/biof.1154
   Das P, 2019, BMC GENOMICS, V20, DOI 10.1186/s12864-019-5591-7
   Dash NR, 2021, DIABETES METAB J, V45, P77, DOI 10.4093/dmj.2019.0202
   Ebenuwa I, 2022, AM J CLIN NUTR, V116, P274, DOI 10.1093/ajcn/nqac063
   Ersoy B, 2009, FOOD CHEM, V115, P419, DOI 10.1016/j.foodchem.2008.12.018
   Franzosa EA, 2018, NAT METHODS, V15, P962, DOI 10.1038/s41592-018-0176-y
   Cano PG, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0041079
   Graupner M, 2002, J BACTERIOL, V184, P1952, DOI 10.1128/JB.184.7.1952-1957.2002
   Gurung M, 2020, EBIOMEDICINE, V51, DOI 10.1016/j.ebiom.2019.11.051
   Hughes CF, 2013, ANN CLIN BIOCHEM, V50, P315, DOI 10.1177/0004563212473279
   Infante M, 2021, WORLD J DIABETES, V12, P916, DOI 10.4239/wjd.v12.i7.916
   Jenkins DJA, 2018, J AM COLL CARDIOL, V71, P2570, DOI 10.1016/j.jacc.2018.04.020
   Jiang ZL, 2020, BMC MED, V18, DOI 10.1186/s12916-020-01842-0
   Katsirma Z, 2021, FOOD FUNCT, V12, P8850, DOI [10.1039/d1fo01125a, 10.1039/D1FO01125A]
   Klaassen MAY, 2019, J CROHNS COLITIS, V13, P1439, DOI 10.1093/ecco-jcc/jjz077
   Kulkarni AS, 2020, CELL METAB, V32, P15, DOI 10.1016/j.cmet.2020.04.001
   Kurilshikov A, 2019, CIRC RES, V124, P1808, DOI 10.1161/CIRCRESAHA.118.314642
   Langmead B, 2012, NAT METHODS, V9, P357, DOI [10.1038/NMETH.1923, 10.1038/nmeth.1923]
   LeBlanc JG, 2017, MICROB CELL FACT, V16, DOI 10.1186/s12934-017-0691-z
   Liang XM, 2015, MOL PHARMACEUT, V12, P4301, DOI 10.1021/acs.molpharmaceut.5b00501
   Liu KL, 2019, FOOD CHEM, V280, P59, DOI 10.1016/j.foodchem.2018.12.053
   Magnusdottir S, 2015, FRONT GENET, V6, DOI 10.3389/fgene.2015.00148
   Makki K, 2018, CELL HOST MICROBE, V23, P705, DOI 10.1016/j.chom.2018.05.012
   Mallick H, 2021, PLOS COMPUT BIOL, V17, DOI 10.1371/journal.pcbi.1009442
   Margalit I, 2018, ANN NUTR METAB, V72, P265, DOI 10.1159/000488326
   Mazur-Bialy AI, 2016, MOLECULES, V21, DOI 10.3390/molecules21121724
   Mikkelsen K., 2019, NUTR IMMUN, P115, DOI DOI 10.1007/978-3-030-16073-9_7
   NILSSON TK, 1990, J INTERN MED, V227, P267, DOI 10.1111/j.1365-2796.1990.tb00156.x
   Nogal A, 2021, GUT MICROBES, V13, DOI 10.1080/19490976.2021.1897212
   Pham V, 2021, NUTR RES, V95, P35, DOI 10.1016/j.nutres.2021.09.001
   Pittas AG, 2007, J CLIN ENDOCR METAB, V92, P2017, DOI 10.1210/jc.2007-0298
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Risch M, 2015, BMC GERIATR, V15, DOI 10.1186/s12877-015-0060-x
   Saeedi P, 2019, DIABETES RES CLIN PR, V157, DOI 10.1016/j.diabres.2019.107843
   Segata N, 2012, NAT METHODS, V9, P811, DOI [10.1038/NMETH.2066, 10.1038/nmeth.2066]
   Suwannasom N, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21030950
   Thakur K, 2017, CRIT REV FOOD SCI, V57, P3650, DOI 10.1080/10408398.2016.1145104
   Ting RZW, 2006, ARCH INTERN MED, V166, P1975, DOI 10.1001/archinte.166.18.1975
   Vila AV, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-019-14177-z
   von Martels JZH, 2020, J CROHNS COLITIS, V14, P595, DOI 10.1093/ecco-jcc/jjz208
   Wang DM, 2019, FEBS OPEN BIO, V9, P1552, DOI 10.1002/2211-5463.12694
   Xu YY, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.02780
   Yang WJ, 2019, J DIABETES, V11, P729, DOI 10.1111/1753-0407.12900
   Yao HY, 2020, GENES NUTR, V15, DOI 10.1186/s12263-020-00671-3
   Yarmolinsky J, 2016, SCI REP-UK, V6, DOI 10.1038/srep17714
   Zhang XY, 2021, NATURE AGING, V1, P87, DOI 10.1038/s43587-020-00014-2
   Zhernakova A, 2016, SCIENCE, V352, P565, DOI 10.1126/science.aad3369
   Zhernakova DV, 2018, NAT GENET, V50, P1524, DOI 10.1038/s41588-018-0224-7
NR 54
TC 0
Z9 0
U1 9
U2 9
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1949-0976
EI 1949-0984
J9 GUT MICROBES
JI Gut Microbes
PD DEC 31
PY 2022
VL 14
IS 1
AR 2154550
DI 10.1080/19490976.2022.2154550
PG 12
WC Gastroenterology & Hepatology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Microbiology
GA 6U1GX
UT WOS:000894118800001
PM 36474346
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Jin, DX
   He, JF
   Luo, XG
   Zhang, TC
AF Jin, Du-Xin
   He, Jun-Fang
   Luo, Xue-Gang
   Zhang, Tong-Cun
TI Hypoglycemic effect of Hypericum attenuatum Choisy extracts on type 2
   diabetes by regulating glucolipid metabolism and modulating gut
   microbiota
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE H. attenuatum Choisy; Gut microflora; Type 2 diabetes mellitus; Short
   chain fatty acids; Inflammation
ID LACTOBACILLUS-GG; RUGOSA THUNB; OBESITY; INFLAMMATION; METFORMIN;
   MELLITUS; DIET; RATS; INDIVIDUALS; PATHWAY
AB Hypericum attenuatum Choisy, as an edible medicinal plant, possesses multiple therapeutic effects. Type 2 diabetes is a metabolic disorder that has become a major threat to public health. The objective of this study was to investigate the hypoglycemic effect of Hypericum attenuatum Choisy extracts (HaC) on T2DM mice and modulatory effect of HaC on composition of intestinal microflora. T2DM mice were treated with HaC for 5 weeks. HaC could modulate fasting blood glucose, improve hepatic insulin sensitivity and promote hepatic glycogen storage by activating IRS1/PI3K/AKT pathway. Moreover, HaC regulated dysfunctional lipid metabolism and reduced inflammation in T2DM mice. Additionally, HaC treatment could modulate the compositions of gut microbiota in small intestine and colon with the altered abundances of Firmicutes, Bacteroidetes and Proteobacteria. Meanwhile, HaC treatment could augment short chain fatty acids contents. These results demonstrate that H. attenuatum Choisy may be a potential therapy for the treatment of T2DM.
C1 [Jin, Du-Xin; He, Jun-Fang] Tianjin Univ Sci & Technol, Coll Biotechnol, Minist Educ, Key Lab Ind Fermentat Microbiol, Tianjin 300457, Peoples R China.
   [Jin, Du-Xin; He, Jun-Fang] Tianjin Univ Sci & Technol, Coll Biotechnol, Tianjin Key Lab Ind Microbiol, Tianjin 300457, Peoples R China.
   [Jin, Du-Xin; He, Jun-Fang; Luo, Xue-Gang; Zhang, Tong-Cun] State Key Lab Food Nutr & Safety, Tianjin 300457, Peoples R China.
C3 Tianjin University Science & Technology; Tianjin University Science &
   Technology
RP Luo, XG; Zhang, TC (通讯作者)，State Key Lab Food Nutr & Safety, Tianjin 300457, Peoples R China.
EM luoxuegang@hotmail.com; tony@tust.edu.cn
RI Zhang, tong/IAP-2587-2023; Zhang, Tong/HGC-1090-2022
FU National Key Research and Development Program of China [2017YF0400304];
   Natural Science Foundation of Tianjin [18JCZDJC33800]; Young Teachers'
   Innovation Fund of Tianjin University of Science and Technology
   [2016LG06]
FX This work was supported by the National Key Research and Development
   Program of China (2017YF0400304), the Natural Science Foundation of
   Tianjin (No. 18JCZDJC33800) and the Young Teachers' Innovation Fund of
   Tianjin University of Science and Technology (No. 2016LG06).
CR Almeer RS, 2018, FOOD CHEM TOXICOL, V115, P49, DOI 10.1016/j.fct.2018.03.002
   Arvola T, 1999, PEDIATRICS, V104, part. no., DOI 10.1542/peds.104.5.e64
   Barthel A, 2003, AM J PHYSIOL-ENDOC M, V285, pE685, DOI 10.1152/ajpendo.00253.2003
   Bindels LB, 2013, TRENDS PHARMACOL SCI, V34, P226, DOI 10.1016/j.tips.2013.02.002
   Burcelin R, 2011, ACTA DIABETOL, V48, P257, DOI 10.1007/s00592-011-0333-6
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   Chassaing B, 2015, NATURE, V519, P92, DOI 10.1038/nature14232
   Donath MY, 2011, NAT REV IMMUNOL, V11, P98, DOI 10.1038/nri2925
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Fan YB, 2018, BIOMED PHARMACOTHER, V106, P733, DOI 10.1016/j.biopha.2018.06.089
   Garber A, 2009, LANCET, V373, P473, DOI 10.1016/S0140-6736(08)61246-5
   Garcia-Mantrana I, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.00890
   Gilbert ER, 2011, EXP DIABETES RES, DOI 10.1155/2011/416254
   Gregor MF, 2011, ANNU REV IMMUNOL, V29, P415, DOI 10.1146/annurev-immunol-031210-101322
   Guarner F, 2003, LANCET, V361, P512, DOI 10.1016/S0140-6736(03)12489-0
   Han F, 2018, J AGR FOOD CHEM, V66, P6326, DOI 10.1021/acs.jafc.8b01891
   Ho CK, 2016, MOL GENET METAB, V119, P288, DOI 10.1016/j.ymgme.2016.09.007
   Husain GM, 2009, DRUG DISCOV THER, V3, P215
   Hussain A, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0165483
   Jia W, 2008, NAT REV DRUG DISCOV, V7, P123, DOI 10.1038/nrd2505
   Kovatcheva-Datchary P, 2015, CELL METAB, V22, P971, DOI 10.1016/j.cmet.2015.10.001
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Lee JS, 2007, DIABETES RES CLIN PR, V77, pS49, DOI 10.1016/j.diabres.2007.01.033
   Lee Yoon Jeong, 2013, [Applied Microscopy, 한국현미경학회지], V43, P54
   Liu L, 2018, BIOMED PHARMACOTHER, V100, P29, DOI 10.1016/j.biopha.2018.01.143
   Liu L, 2017, J ETHNOPHARMACOL, V200, P174, DOI 10.1016/j.jep.2017.02.022
   Liu TY, 2015, CLIN SCI, V129, P839, DOI 10.1042/CS20150009
   Lochhead PA, 2001, DIABETES, V50, P937, DOI 10.2337/diabetes.50.5.937
   Ma YX, 2014, J TRADIT CHIN MED, V34, P357, DOI 10.1016/S0254-6272(14)60102-3
   Matsuzaki T, 1997, ENDOCR J, V44, P357, DOI 10.1507/endocrj.44.357
   Moller DE, 2001, NATURE, V414, P821, DOI 10.1038/414821a
   Moon JH, 2001, FREE RADICAL BIO MED, V30, P1274, DOI 10.1016/S0891-5849(01)00522-6
   Morshedloo MR, 2015, IND CROP PROD, V76, P565, DOI 10.1016/j.indcrop.2015.07.033
   Nauck M, 2009, DIABETES CARE, V32, P84, DOI 10.2337/dc08-1355
   Ning C, 2017, MOL NUTR FOOD RES, V61, DOI 10.1002/mnfr.201600673
   Nordlie RC, 1999, ANNU REV NUTR, V19, P379, DOI 10.1146/annurev.nutr.19.1.379
   Okin D, 2016, CELL, V165, P343, DOI 10.1016/j.cell.2016.02.023
   Patterson E, 2016, POSTGRAD MED J, V92, P286, DOI 10.1136/postgradmedj-2015-133285
   Perez-Ramirez IF, 2017, J FUNCT FOODS, V35, P24, DOI 10.1016/j.jff.2017.05.028
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Rengasamy KRR, 2019, PHARMACOL THERAPEUT, V194, P107, DOI 10.1016/j.pharmthera.2018.09.009
   Rosenblit PD, 2016, CARDIOVASC DIABETOL, V15, DOI 10.1186/s12933-016-0412-7
   Sheng LL, 2017, J PATHOL, V243, P431, DOI 10.1002/path.4983
   Song JJ, 2017, BRIT J NUTR, V118, P481, DOI [10.1017/S0007114517002380, 10.1017/s0007114517002380]
   Stage TB, 2016, BASIC CLIN PHARMACOL, V118, P219, DOI 10.1111/bcpt.12486
   Tabuchi M, 2003, BIOSCI BIOTECH BIOCH, V67, P1421, DOI 10.1271/bbb.67.1421
   Turnbaugh PJ, 2008, CELL HOST MICROBE, V3, P213, DOI 10.1016/j.chom.2008.02.015
   Vijay-Kumar M, 2010, SCIENCE, V328, P228, DOI 10.1126/science.1179721
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Wu JJ, 2017, CARBOHYD POLYM, V178, P209, DOI 10.1016/j.carbpol.2017.09.050
   Yan HL, 2017, PHYTOMEDICINE, V26, P45, DOI 10.1016/j.phymed.2017.01.007
   Zhang CH, 2010, ISME J, V4, P232, DOI 10.1038/ismej.2009.112
   Zhang WY, 2017, J FUNCT FOODS, V39, P139, DOI 10.1016/j.jff.2017.10.020
   Zhao LP, 2018, SCIENCE, V359, P1151, DOI 10.1126/science.aao5774
   Zheng JP, 2018, CARBOHYD POLYM, V190, P77, DOI 10.1016/j.carbpol.2018.02.058
   Zinman B, 2009, DIABETES CARE, V32, P1224, DOI 10.2337/dc08-2124
NR 56
TC 28
Z9 30
U1 5
U2 75
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD JAN
PY 2019
VL 52
BP 479
EP 491
DI 10.1016/j.jff.2018.11.031
PG 13
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA HH4KR
UT WOS:000455691800052
DA 2023-06-08
ER

PT J
AU Therdtatha, P
   Song, YY
   Tanaka, M
   Mariyatun, M
   Almunifah, M
   Manurung, NEP
   Indriarsih, S
   Lu, Y
   Nagata, K
   Fukami, K
   Ikeda, T
   Lee, YK
   Rahayu, ES
   Nakayama, J
AF Therdtatha, Phatthanaphong
   Song, Yayi
   Tanaka, Masaru
   Mariyatun, Mariyatun
   Almunifah, Maisaroh
   Manurung, Nancy Eka Putri
   Indriarsih, Siska
   Lu, Yi
   Nagata, Koji
   Fukami, Katsuya
   Ikeda, Tetsuo
   Lee, Yuan-Kun
   Rahayu, Endang Sutriswati
   Nakayama, Jiro
TI Gut Microbiome of Indonesian Adults Associated with Obesity and Type 2
   Diabetes: A Cross-Sectional Study in an Asian City, Yogyakarta
SO MICROORGANISMS
LA English
DT Article
DE gut microbiome; bile acids; dietary habits; obesity; type 2 diabetes
ID CHAIN FATTY-ACIDS; CHILDREN; RECEPTOR; SUCCINATE; IMPACT; RISK;
   CLASSIFICATION; BACTEROIDES; HOMEOSTASIS; METFORMIN
AB Indonesia is a developing country facing the national problem of the growing obesity and diabetes in its population due to recent drastic dietary and lifestyle changes. To understand the link between the gut microbiome, diet, and health of Indonesian people, fecal microbiomes and metabolomes of 75 Indonesian adults in Yogyakarta City, including obese people (n = 21), type 2 diabetes (T2D) patients (n = 25), and the controls (n = 29) were characterized together with their dietary and medical records. Variations of microbiomes showed a triangular distribution in the principal component analysis, driven by three dominant bacterial genera, namely Bacteroides, Prevotella, and Romboutsia. The Romboutsia-driven microbiome, characterized by low bacterial diversity and high primary bile acids, was associated with fat-driven obesity. The Bacteroides-driven microbiome, which counteracted Prevotella but was associated with Ruminococcaceae concomitantly increased with high-carbohydrate diets, showed positive correlation with T2D indices but negative correlation with body mass index. Notably, Bacteroides fragilis was increased in T2D patients with a decrease in fecal conjugated bile acids, particularly tauroursodeoxycholic acid (TUDCA), a farnesoid X receptor (FXR) antagonist with anti-diabetic activity, while these features disappeared in patients administered metformin. These results indicate that the gut microbiome status of Indonesian adults is differently associated with obesity and T2D under their varied dietary habits.
C1 [Therdtatha, Phatthanaphong; Song, Yayi; Tanaka, Masaru; Nakayama, Jiro] Kyushu Univ, Fac Agr, Dept Biosci & Biotechnol, Nishi Ku, 744 Motooka, Fukuoka 8190395, Japan.
   [Mariyatun, Mariyatun; Almunifah, Maisaroh; Manurung, Nancy Eka Putri; Indriarsih, Siska; Rahayu, Endang Sutriswati] Univ Gadjah Mada, Fac Agr Technol, Yogyakarta 55281, Indonesia.
   [Lu, Yi; Nagata, Koji] Univ Tokyo, Grad Sch Agr & Life Sci, Dept Appl Biol Chem, Bunkyo Ku, 1-1-1 Yayoi, Tokyo 1138657, Japan.
   [Fukami, Katsuya] Kyushu Univ, Mat Management Ctr, Nishi Ku, 744 Motooka, Fukuoka 8190395, Japan.
   [Ikeda, Tetsuo] Kyushu Univ, Grad Sch Med Sci, Dept Surg & Sci, Higashi Ku, 3-1-1 Maidashi, Fukuoka 8128582, Japan.
   [Ikeda, Tetsuo] Fukuoka Dent Coll, Endoscopy & Endoscop Surg, Sawara Ku, 2-15-1 Tamura, Fukuoka 8140193, Japan.
   [Lee, Yuan-Kun] Natl Univ Singapore, Dept Microbiol & Immunol, 5 Sci Dr 2, Singapore 117545, Singapore.
C3 Kyushu University; Gadjah Mada University; University of Tokyo; Kyushu
   University; Kyushu University; Fukuoka Dental College (FDC); National
   University of Singapore
RP Nakayama, J (通讯作者)，Kyushu Univ, Fac Agr, Dept Biosci & Biotechnol, Nishi Ku, 744 Motooka, Fukuoka 8190395, Japan.
EM vo_21851@hotmail.com; lana745143663@gmail.com; msr456852@gmail.com;
   maria_slimshady@yahoo.com; almunifah@gmail.com; nancyekaputri@gmail.com;
   siskaindriarsih@gmail.com; ly22999@hotmail.com;
   aknagata@mail.ecc.u-tokyo.ac.jp; kfukami@mmc.kyushu-u.ac.jp;
   t-ikeda@surg2.med.kyushu-u.ac.jp; micleeyk@nus.edu.sg;
   endangsrahayu@ugm.ac.id; nakayama@agr.kyushu-u.ac.jp
OI Eka Putri Manurung, Nancy/0000-0002-5182-7433; Nagata,
   Koji/0000-0002-4704-0603; Song, Yayi/0000-0001-7875-4265
FU JSPS KAKENHI [JP 17H04620, 20KK0130]; Mishima Kaiun Memorial Foundation;
   Kieikai Research Foundation; Japanese Government (MEXT); Grants-in-Aid
   for Scientific Research [20KK0130] Funding Source: KAKEN
FX This study was supported by JSPS KAKENHI Grant Numbers JP 17H04620 and
   20KK0130 (to J.N.), by Mishima Kaiun Memorial Foundation (to J.N.), and
   by Kieikai Research Foundation (to J.N.), and by the Japanese Government
   (MEXT) scholarship students (to P.T.).
CR [Anonymous], 2019, IDF DIABETES ATLAS
   Astrup A, 2000, Obes Rev, V1, P57, DOI 10.1046/j.1467-789x.2000.00013.x
   Begley M, 2005, FEMS MICROBIOL REV, V29, P625, DOI 10.1016/j.femsre.2004.09.003
   Boulange CL, 2016, GENOME MED, V8, DOI 10.1186/s13073-016-0303-2
   Burcelin R, 2016, MOL METAB, V5, P771, DOI 10.1016/j.molmet.2016.05.016
   Byrne CS, 2015, INT J OBESITY, V39, P1331, DOI 10.1038/ijo.2015.84
   Chan JCN, 2009, JAMA-J AM MED ASSOC, V301, P2129, DOI 10.1001/jama.2009.726
   Chen TT, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-02995-4
   De Filippo C, 2010, P NATL ACAD SCI USA, V107, P14691, DOI 10.1073/pnas.1005963107
   De Vadder F, 2016, CELL METAB, V24, P151, DOI 10.1016/j.cmet.2016.06.013
   Durban A., 2013, METAGENOMICS, V2, P1, DOI [10.4303/mg/235722, DOI 10.4303/MG/235722]
   Edgar R. C., 2016, SINTAX SIMPLE NONBAY, DOI [10.1101/074161, DOI 10.1101/074161V1, DOI 10.1101/074161]
   Edgar RC, 2013, NAT METHODS, V10, P996, DOI [10.1038/nmeth.2604, 10.1038/NMETH.2604]
   Fabbrini E, 2015, J CLIN INVEST, V125, P787, DOI 10.1172/JCI78425
   Faith DP, 2006, EVOL BIOINFORM, V2, P121
   Fernandez-Veledo S, 2019, REV ENDOCR METAB DIS, V20, P439, DOI 10.1007/s11154-019-09513-z
   Ferrell JM, 2019, DIABETES METAB J, V43, P257, DOI 10.4093/dmj.2019.0043
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Goncalves P, 2018, INFLAMM BOWEL DIS, V24, P558, DOI 10.1093/ibd/izx029
   Graessler J, 2013, PHARMACOGENOMICS J, V13, P514, DOI 10.1038/tpj.2012.43
   Herlemann DPR, 2011, ISME J, V5, P1571, DOI 10.1038/ismej.2011.41
   Hussain A., 2018, J DIABETOL, V9, P70, DOI [10.4103/jod.jod_22_18, DOI 10.4103/JOD.JOD_22_18]
   Kahn SE, 2006, NATURE, V444, P840, DOI 10.1038/nature05482
   Kawamata Y, 2003, J BIOL CHEM, V278, P9435, DOI 10.1074/jbc.M209706200
   Kisuse J, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.01345
   Kuczynski Justin, 2011, Curr Protoc Bioinformatics, VChapter 10, DOI [10.1002/9780471729259.mc01e05s27, 10.1002/0471250953.bi1007s36]
   Le Chatelier E, 2013, NATURE, V500, P541, DOI 10.1038/nature12506
   Lee JWR, 2011, DIABETES CARE, V34, P353, DOI 10.2337/dc10-0746
   Lin Y, 2016, ONCOTARGET, V7, P29454, DOI 10.18632/oncotarget.8762
   Makishima M, 1999, SCIENCE, V284, P1362, DOI 10.1126/science.284.5418.1362
   Matsuki T, 2004, APPL ENVIRON MICROB, V70, P7220, DOI 10.1128/AEM.70.12.7220-7228.2004
   Meigs JB, 2006, J CLIN ENDOCR METAB, V91, P2906, DOI 10.1210/jc.2006-0594
   Nakayama J, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.00197
   Nakayama J, 2015, SCI REP-UK, V5, DOI 10.1038/srep08397
   Napolitano A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100778
   Oddo VM, 2019, BMJ OPEN, V9, DOI 10.1136/bmjopen-2019-031198
   Pan A, 2012, CIRCULATION, V126, P163, DOI 10.1161/CIRCULATIONAHA.112.115923
   Pathak P, 2018, HEPATOLOGY, V68, P1574, DOI 10.1002/hep.29857
   Psichas A, 2015, INT J OBESITY, V39, P424, DOI 10.1038/ijo.2014.153
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Ramachandran A, 2012, DIABETES-METAB RES, V28, P47, DOI 10.1002/dmrr.2353
   Rhee EJ, 2015, ENDOCRINOL METAB, V30, P263, DOI 10.3803/EnM.2015.30.3.263
   Rios-Covian D, 2016, FRONT MICROBIOL, V7, DOI 10.3389/fmicb.2016.00185
   Ruengsomwong S, 2016, J MICROBIOL BIOTECHN, V26, P1723, DOI 10.4014/jmb.1603.03057
   Sansome DJ, 2020, DIABETES OBES METAB, V22, P141, DOI 10.1111/dom.13869
   Scarpello JHB, 1998, DIABETIC MED, V15, P651, DOI 10.1002/(SICI)1096-9136(199808)15:8<651::AID-DIA628>3.0.CO;2-A
   Segata N, 2011, GENOME BIOL, V12, DOI 10.1186/gb-2011-12-6-r60
   Seino Y, 2010, DIABETOL INT, V1, P2, DOI 10.1007/s13340-010-0006-7
   Sekiyama M, 2012, ASIA PAC J CLIN NUTR, V21, P558
   Serena C, 2018, ISME J, V12, P1642, DOI 10.1038/s41396-018-0068-2
   Shannon C. E., 1948, BELL SYST TECH J, V27, P379, DOI [10.1002/j.1538-7305.1948.tb01338.x, DOI 10.1002/J.1538-7305.1948.TB00917.X, DOI 10.1002/J.1538-7305.1948.TB01338.X]
   Shima KR, 2018, BMJ OPEN DIAB RES CA, V6, DOI 10.1136/bmjdrc-2017-000469
   Song ZW, 2019, MICROBIOME, V7, DOI 10.1186/s40168-019-0628-3
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Susetyowati, 2019, KNE LIFE SCI, P86, DOI 10.18502/kls.v4i11.3855
   Tanaka M, 2020, GUT MICROBES, V11, P205, DOI 10.1080/19490976.2019.1650997
   Tsuchida T, 2012, METABOLISM, V61, P944, DOI 10.1016/j.metabol.2011.10.023
   Vettorazzi JF, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-13974-0
   Wang JJ, 2020, J DIABETES RES, V2020, DOI 10.1155/2020/6047145
   Wang K, 2019, CELL REP, V26, P222, DOI 10.1016/j.celrep.2018.12.028
   WHO, 2016, WORLD HLTH ORG DIAB
   WHO Consultation, 2000, WHO TECH REP SER, V894, P1
   Wu GD, 2011, SCIENCE, V334, P105, DOI 10.1126/science.1208344
   Zeng Q, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-49462-w
   Zhao H, 2019, FEBS LETT, V593, P2655, DOI 10.1002/1873-3468.13527
   Zhao L, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00233
NR 66
TC 9
Z9 9
U1 4
U2 14
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-2607
J9 MICROORGANISMS
JI Microorganisms
PD MAY
PY 2021
VL 9
IS 5
AR 897
DI 10.3390/microorganisms9050897
PG 19
WC Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology
GA ST4RG
UT WOS:000662432100001
PM 33922321
OA gold, Green Published, Green Submitted
DA 2023-06-08
ER

PT J
AU Le Bastard, Q
   Al-Ghalith, GA
   Gregoire, M
   Chapelet, G
   Javaudin, F
   Dailly, E
   Batard, E
   Knights, D
   Montassier, E
AF Le Bastard, Q.
   Al-Ghalith, G. A.
   Gregoire, M.
   Chapelet, G.
   Javaudin, F.
   Dailly, E.
   Batard, E.
   Knights, D.
   Montassier, E.
TI Systematic review: human gut dysbiosis induced by non-antibiotic
   prescription medications
SO ALIMENTARY PHARMACOLOGY & THERAPEUTICS
LA English
DT Review
AB Background: Global prescription drug use has been increasing continuously for decades. The gut microbiome, a key contributor to health status, can be altered by prescription drug use, as antibiotics have been repeatedly described to have both short-term and long-standing effects on the intestinal microbiome.
   Aim: To summarise current findings on non-antibiotic prescription-induced gut microbiome changes, focusing on the most frequently prescribed therapeutic drug categories.
   Methods: We conducted a systematic review by first searching in online databases for indexed articles and abstracts in accordance with PRISMA guidelines. Studies assessing the intestinal microbiome alterations associated with proton pump inhibitors (PPIs), metformin, nonsteroidal anti-inflammatory drugs (NSAIDs), opioids, statins and antipsychotics were included. We only included studies using culture-independent molecular techniques.
   Results: Proton pump inhibitors and antipsychotic medications are associated with a decrease in diversity in the gut microbiome, whereas opioids were associated with an increase in diversity. Metformin and NSAIDs were not associated with significant changes in diversity. diversity was found to be significantly altered with all drugs, except for NSAIDs. PPI use was linked to a decrease in Clotridiales and increase in Actinomycetales, Micrococcaceae and Streptococcaceae, which are changes previously implicated in dysbiosis and increased susceptibility to Clostridium difficile infection. Consistent results showed that PPIs, metformin, NSAIDs, opioids and antipsychotics were either associated with increases in members of class Gammaproteobacteria (including Enterobacter, Escherichia, Klebsiella and Citrobacter), or members of family Enterococcaceae, which are often pathogens isolated from bloodstream infections in critically ill patients. We also found that antipsychotic treatment, usually associated with an increase in body mass index, was marked by a decreased ratio of Bacteroidetes:Firmicutes in the gut microbiome, resembling trends seen in obese patients.
   Conclusions: Non-antibiotic prescription drugs have a notable impact on the overall architecture of the intestinal microbiome. Further explorations should seek to define biomarkers of dysbiosis induced by specific drugs, and potentially tailor live biotherapeutics to counter this drug-induced dysbiosis. Many other frequently prescribed drugs should also be investigated to better understand the link between these drugs, the microbiome and health status.
C1 [Le Bastard, Q.; Gregoire, M.; Chapelet, G.; Javaudin, F.; Dailly, E.; Batard, E.; Montassier, E.] Univ Nantes, Inst Rech Sante 2, MiHAR Lab, Nantes, France.
   [Al-Ghalith, G. A.; Knights, D.] Univ Minnesota, Biotechnol Inst, St Paul, MN 55108 USA.
   [Al-Ghalith, G. A.; Knights, D.] Univ Minnesota, Dept Comp Sci & Engn, Minneapolis, MN USA.
C3 Nantes Universite; University of Minnesota System; University of
   Minnesota Twin Cities; University of Minnesota System; University of
   Minnesota Twin Cities
RP Montassier, E (通讯作者)，Univ Nantes, Inst Rech Sante 2, MiHAR Lab, Nantes, France.
EM emmanuel.montassier@chu-nantes.fr
RI LE BASTARD, Quentin/AAF-1498-2021; Javaudin, François/AAN-9610-2020;
   Montassier, Emmanuel/AAH-4602-2020; Grégoire, Matthieu/E-4014-2018
OI LE BASTARD, Quentin/0000-0001-6930-0720; Grégoire,
   Matthieu/0000-0003-1232-5761; Dailly, Eric/0000-0002-5400-335X; Batard,
   Eric/0000-0002-1927-228X
NR 0
TC 124
Z9 126
U1 2
U2 53
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0269-2813
EI 1365-2036
J9 ALIMENT PHARM THER
JI Aliment. Pharmacol. Ther.
PD FEB
PY 2018
VL 47
IS 3
BP 332
EP 345
DI 10.1111/apt.14451
PG 14
WC Gastroenterology & Hepatology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Pharmacology & Pharmacy
GA FS2CP
UT WOS:000419586100002
PM 29205415
OA Bronze
DA 2023-06-08
ER

PT J
AU Zhao, LJ
   Lou, HX
   Peng, Y
   Chen, SH
   Zhang, YL
   Li, XB
AF Zhao, Lijuan
   Lou, Hongxiang
   Peng, Ying
   Chen, Shihong
   Zhang, Yulong
   Li, Xiaobo
TI Comprehensive relationships between gut microbiome and faecal metabolome
   in individuals with type 2 diabetes and its complications
SO ENDOCRINE
LA English
DT Article
DE Gut microbiota; Faecal metabolites; Short chain fatty acid; Correlation;
   Type 2 diabetes
ID SERUM METABOLOME; WEIGHT; OBESITY; IMPACT; ACIDS; INFLAMMATION;
   ASSOCIATION; METAGENOME; SIGNATURES; MELLITUS
AB Purpose As the treatment regimens such as metformin could confound the correlation between type 2 diabetes (T2D) and gut microbiome, we should revisit the relationship between gut microbiota and T2D patients who are not currently treated with metformin. Methods The study recruited 65 T2D patients: 49 with and 16 without diabetic complications, and 35 healthy controls. We sequenced the 16S rRNA V3-V4 region of gut microbiota and detected metabolites based on liquid chromatography mass spectrometry (LC/MS) and gas chromatography mass spectrometry (GC/MS) in faecal samples. Results The composition of both the gut microbiota and faecal metabolites changed significantly with T2D patients. The abundance of Proteobacteria and the ratio of Firmicutes/Bacteroidetes were higher in T2D patients than healthy subjects, and the short chain fatty acids (SCFAs), bile acids and lipids of T2D patients were significantly disordered. Moreover, the abundances of certain SCFA-producing bacteria (Lachnospiraceae and Ruminococcaceae etc.) were significantly increased in T2D patients, while the faecal SCFAs concentrations were significantly decreased. It's suggested that the role of SCFA-producing bacteria was not simply to produce SCFAs. Then we identified 44 microbial modules to explore the correlations between the gut microbiota and metabolic traits. Specially, most modules including certain SCFA-producing bacteria were comprehensively correlated to body mass index, the levels of blood glucose, blood pressure, blood cholesterol and faecal bile acids and lipids. Conclusions Our study identified the relationships between the gut microbiota and faecal metabolites, and provided a resource for future studies to understand host-gut microbiota interactions in T2D.
C1 [Zhao, Lijuan; Peng, Ying; Zhang, Yulong; Li, Xiaobo] Shanghai Jiao Tong Univ, Sch Pharm, 800 Dongchuan Rd, Shanghai 200240, Peoples R China.
   [Lou, Hongxiang] Shandong Univ, Sch Pharmaceut Sci, Minist Educ, Key Lab Chem Biol, 44 Wenhuaxi Rd, Jinan 250012, Shandong, Peoples R China.
   [Chen, Shihong] Shandong Univ, Hosp 2, Dept Endocrinol, 247 Beiyuan Rd, Jinan 250033, Shandong, Peoples R China.
C3 Shanghai Jiao Tong University; Shandong University; Shandong University
RP Li, XB (通讯作者)，Shanghai Jiao Tong Univ, Sch Pharm, 800 Dongchuan Rd, Shanghai 200240, Peoples R China.
EM xbli@sjtu.edu.cn
OI Li, Xiaobo/0000-0002-7500-9275
FU National Natural Science Foundation of China [81673588]
FX This study was funded by the National Natural Science Foundation of
   China (No. 81673588).
CR Allin KH, 2018, DIABETOLOGIA, V61, P810, DOI 10.1007/s00125-018-4550-1
   Amer Diabet Assoc, 2014, DIABETES CARE, V37, pS14, DOI 10.2337/dc14-S014
   Basevi V, 2011, DIABETES CARE, V34, P1887, DOI 10.2337/dc11-s011
   Brial F, 2018, CELL MOL LIFE SCI, V75, P3977, DOI 10.1007/s00018-018-2901-1
   Canfora EE, 2015, NAT REV ENDOCRINOL, V11, P577, DOI 10.1038/nrendo.2015.128
   Cao HC, 2011, ANAL CHIM ACTA, V691, P68, DOI 10.1016/j.aca.2011.02.038
   Caporaso JG, 2010, NAT METHODS, V7, P335, DOI 10.1038/nmeth.f.303
   Chavez-Talavera O, 2017, GASTROENTEROLOGY, V152, P1679, DOI 10.1053/j.gastro.2017.01.055
   de Vos WM, 2013, NATURE, V498, P48, DOI 10.1038/nature12251
   Dodd D, 2017, NATURE, V551, P648, DOI 10.1038/nature24661
   Edgar RC, 2010, BIOINFORMATICS, V26, P2460, DOI 10.1093/bioinformatics/btq461
   Escobar JS, 2014, BMC MICROBIOL, V14, DOI 10.1186/s12866-014-0311-6
   Feng WW, 2019, PHARMACOL RES, V142, P176, DOI 10.1016/j.phrs.2019.02.024
   Fernandes J, 2014, NUTR DIABETES, V4, DOI 10.1038/nutd.2014.23
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Furet JP, 2010, DIABETES, V59, P3049, DOI 10.2337/db10-0253
   Hartstra AV, 2016, TRENDS FOOD SCI TECH, V57, P233, DOI 10.1016/j.tifs.2016.08.009
   Hartstra AV, 2015, DIABETES CARE, V38, P159, DOI 10.2337/dc14-0769
   Jie ZY, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-00900-1
   Joyce SA, 2014, P NATL ACAD SCI USA, V111, P7421, DOI 10.1073/pnas.1323599111
   Kakiyama G, 2013, J HEPATOL, V58, P949, DOI 10.1016/j.jhep.2013.01.003
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Koh A, 2018, CELL, V175, P947, DOI 10.1016/j.cell.2018.09.055
   Langfelder P, 2008, BIOINFORMATICS, V24, P719, DOI 10.1093/bioinformatics/btm563
   Langfelder P, 2008, BMC BIOINFORMATICS, V9, DOI 10.1186/1471-2105-9-559
   Langille MGI, 2013, NAT BIOTECHNOL, V31, P814, DOI 10.1038/nbt.2676
   Li J, 2017, MICROBIOME, V5, DOI 10.1186/s40168-016-0222-x
   Li Y, 2018, FRONT PHARMACOL, V9, DOI 10.3389/fphar.2018.00967
   Liu FP, 2017, FRONT PHYSIOL, V8, DOI 10.3389/fphys.2017.00126
   Liu HH, 2019, MICROBIOME, V7, DOI 10.1186/s40168-019-0683-9
   Liu RX, 2017, NAT MED, V23, P859, DOI 10.1038/nm.4358
   Lozupone C, 2005, APPL ENVIRON MICROB, V71, P8228, DOI 10.1128/AEM.71.12.8228-8235.2005
   Lynch SV, 2016, NEW ENGL J MED, V375, P2369, DOI 10.1056/NEJMra1600266
   Makki K, 2018, CELL HOST MICROBE, V23, P705, DOI 10.1016/j.chom.2018.05.012
   Martin FPJ, 2008, MOL SYST BIOL, V4, DOI 10.1038/msb4100190
   McDonald D, 2012, ISME J, V6, P610, DOI 10.1038/ismej.2011.139
   Moreno-Indias I, 2016, AM J TRANSL RES, V8, P5672
   Org E, 2017, GENOME BIOL, V18, DOI 10.1186/s13059-017-1194-2
   Parks DH, 2014, BIOINFORMATICS, V30, P3123, DOI 10.1093/bioinformatics/btu494
   Pedersen HK, 2016, NATURE, V535, P376, DOI 10.1038/nature18646
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Ridaura VK, 2013, SCIENCE, V341, P1079, DOI 10.1126/science.1241214
   Sanchez-Alcoholado L, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.01936
   Smith CA, 2005, THER DRUG MONIT, V27, P747, DOI 10.1097/01.ftd.0000179845.53213.39
   Sud M, 2007, NUCLEIC ACIDS RES, V35, pD527, DOI 10.1093/nar/gkl838
   Sze MA, 2016, MBIO, V7, DOI 10.1128/mBio.01018-16
   Tang WHW, 2017, CLIN CHEM, V63, P297, DOI 10.1373/clinchem.2016.263640
   Thomas C, 2009, CELL METAB, V10, P167, DOI 10.1016/j.cmet.2009.08.001
   Trabelsi MS, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms8629
   Vogt JA, 2003, J NUTR, V133, P3145, DOI 10.1093/jn/133.10.3145
   Wahlstrom A, 2016, CELL METAB, V24, P41, DOI 10.1016/j.cmet.2016.05.005
   Wang RJ, 2016, RSC ADV, V6, P60657, DOI 10.1039/c6ra06361f
   Wang ZN, 2011, NATURE, V472, P57, DOI 10.1038/nature09922
   Wishart DS, 2018, NUCLEIC ACIDS RES, V46, pD608, DOI 10.1093/nar/gkx1089
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Wu T, 2015, J PROTEOME RES, V14, P447, DOI 10.1021/pr500825y
   Zhang XZ, 2017, MED SCI MONITOR, V23, P613, DOI 10.12659/MSM.896298
   Zheng XJ, 2017, BMC BIOL, V15, DOI 10.1186/s12915-017-0462-7
NR 58
TC 90
Z9 91
U1 5
U2 81
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1355-008X
EI 1559-0100
J9 ENDOCRINE
JI Endocrine
PD DEC
PY 2019
VL 66
IS 3
BP 526
EP 537
DI 10.1007/s12020-019-02103-8
EA OCT 2019
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA JY1UP
UT WOS:000489534200001
PM 31591683
DA 2023-06-08
ER

PT J
AU Zhou, JC
   Zhang, XW
AF Zhou Ji-Chao
   Zhang Xiao-Wei
TI Akkermansia muciniphila: a promising target for the therapy of metabolic
   syndrome and related diseases
SO CHINESE JOURNAL OF NATURAL MEDICINES
LA English
DT Article
DE Gut microbiota; Metabolic syndrome; Diabetes; Atural medicine
ID DIET-INDUCED OBESITY; GUT MICROBIOTA; INSULIN-RESISTANCE; ASSOCIATION;
   PROTECTS; BACTERIA; INFLAMMATION; POLYPHENOLS; MODULATION; METFORMIN
AB The probiotic Akkermansia muciniphila (A. muciniphila) is an intestinal bacterium that was first identified in human feces in 2004. Its specialization in mucin degradation makes it a key microorganism that maintains intestinal mucosal barrier function. As an unique representative strain of the phylum Verrucomicrobia that can be cultured in vitro, A. muciniphila is much easier to detect by metagenomic analysis of intestinal flora. In the past few years, A. muciniphila has been getting increasing attention for the positive correlation between its intestinal colonization and host homeostatic metabolism. In this review, we summarize the relationship between A. muciniphila and host health and diseases, especially focusing on metabolic diseases and related mechanisms, as well as the natural food and drug-derived substrates affecting its colonization in the host, expecting to provide evidence and clues for the development of drugs targeting A. muciniphila.
C1 [Zhou Ji-Chao; Zhang Xiao-Wei] Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Mol Immunol & Pharmacol Grp, Beijing 100000, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College
RP Zhang, XW (通讯作者)，Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Mol Immunol & Pharmacol Grp, Beijing 100000, Peoples R China.
EM zhxw@imm.ac.cn
FU National Key R&D Program of China [2017YFA0205400]; National Natural
   Science Foundation of China [81773800]; National Drug Innovation Major
   Project of China [2018ZX09711001-003-009]; Chinese Academy of Medical
   Sciences (CAMS) Innovation Fund for Medical Sciences [2016-I2M-1-010]
FX This work was supported by the National Key R&D Program of China (No.
   2017YFA0205400), the National Natural Science Foundation of China (No.
   81773800), National Drug Innovation Major Project of China (No.
   2018ZX09711001-003-009), Chinese Academy of Medical Sciences (CAMS)
   Innovation Fund for Medical Sciences (No. 2016-I2M-1-010).
CR Andersson KE, 2013, EUR J NUTR, V52, P1755, DOI 10.1007/s00394-012-0479-1
   Anhe FF, 2015, GUT, V64, P872, DOI 10.1136/gutjnl-2014-307142
   Axling U, 2012, NUTR METAB, V9, DOI 10.1186/1743-7075-9-105
   Backhed F, 2005, SCIENCE, V307, P1915, DOI 10.1126/science.1104816
   Cekanaviciute E, 2017, P NATL ACAD SCI USA, V114, P10713, DOI 10.1073/pnas.1711235114
   Chang CJ, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms8489
   Chaplin A, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0125091
   Chelakkot C, 2018, EXP MOL MED, V50, DOI 10.1038/emm.2017.282
   Dao MC, 2016, GUT, V65, P426, DOI 10.1136/gutjnl-2014-308778
   Derrien M, 2004, INT J SYST EVOL MICR, V54, P1469, DOI 10.1099/ijs.0.02873-0
   Dubourg G, 2013, INT J ANTIMICROB AG, V41, P149, DOI 10.1016/j.ijantimicag.2012.10.012
   Everard A, 2014, ISME J, V8, P2116, DOI 10.1038/ismej.2014.45
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Everard A, 2011, DIABETES, V60, P2775, DOI 10.2337/db11-0227
   Ferrer M, 2014, GUT MICROBES, V5, P64, DOI 10.4161/gmic.27128
   Gomez-Gallego C, 2016, BENEF MICROBES, V7, P571, DOI 10.3920/BM2016.0009
   Gomez-Gallego C, 2012, J NUTR BIOCHEM, V23, P1508, DOI 10.1016/j.jnutbio.2011.10.003
   Grander C, 2018, GUT, V67, P892, DOI 10.1136/gutjnl-2016-313432
   Halmos EP, 2015, GUT, V64, P93, DOI 10.1136/gutjnl-2014-307264
   Hanninen A, 2018, GUT, V67, P1445, DOI 10.1136/gutjnl-2017-314508
   Hansen CHF, 2012, DIABETOLOGIA, V55, P2285, DOI 10.1007/s00125-012-2564-7
   Hooper LV, 2001, SCIENCE, V291, P881, DOI 10.1126/science.291.5505.881
   Kang CS, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0076520
   Karlsson CLJ, 2012, OBESITY, V20, P2257, DOI 10.1038/oby.2012.110
   Lane JA, 2012, J MICROBIOL METH, V90, P53, DOI 10.1016/j.mimet.2012.03.017
   Le Chatelier E, 2013, NATURE, V500, P541, DOI 10.1038/nature12506
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Li J, 2016, CIRCULATION, V133, P2434, DOI 10.1161/CIRCULATIONAHA.115.019645
   Lukovac S, 2014, MBIO, V5, DOI 10.1128/mBio.01438-14
   Marcial-Coba MS, 2018, FOOD FUNCT, V9, P5868, DOI [10.1039/C8FO01331D, 10.1039/c8fo01331d]
   Nobel YR, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms8486
   Ottman N, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0173004
   Piening BD, 2018, CELL SYST, V6, P157, DOI 10.1016/j.cels.2017.12.013
   Plovier H, 2017, NAT MED, V23, P107, DOI 10.1038/nm.4236
   Png CW, 2010, AM J GASTROENTEROL, V105, P2420, DOI 10.1038/ajg.2010.281
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Rajilic-Stojanovic M, 2014, FEMS MICROBIOL REV, V38, P996, DOI 10.1111/1574-6976.12075
   Reid DT, 2016, EUR J NUTR, V55, P2399, DOI 10.1007/s00394-015-1047-2
   Remely M, 2015, BENEF MICROBES, V6, P431, DOI 10.3920/BM2014.0104
   Reunanen J, 2015, APPL ENVIRON MICROB, V81, P3655, DOI 10.1128/AEM.04050-14
   Roopchand DE, 2015, DIABETES, V64, P2847, DOI 10.2337/db14-1916
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Shoaf K, 2006, INFECT IMMUN, V74, P6920, DOI 10.1128/IAI.01030-06
   Somerville V, 2017, SPORTS MED, V47, P1589, DOI 10.1007/s40279-017-0675-5
   Song HZ, 2016, J GASTROEN HEPATOL, V31, P1462, DOI 10.1111/jgh.13278
   Sonnenburg ED, 2019, NAT REV MICROBIOL, V17, P383, DOI 10.1038/s41579-019-0191-8
   Suez Jotham, 2014, Nature, V514, P181, DOI 10.1038/nature13793
   Swidsinski A, 2011, GUT, V60, P34, DOI 10.1136/gut.2009.191320
   Teixeira TFS, 2013, CLIN NUTR, V32, P1017, DOI 10.1016/j.clnu.2013.02.008
   van Dorsten FA, 2012, J AGR FOOD CHEM, V60, P11331, DOI 10.1021/jf303165w
   Wang JJ, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0092745
   Wang JH, 2015, SCI REP-UK, V5, DOI 10.1038/srep08391
   Wang XM, 2017, CHIN J NAT MEDICINES, V15, P241, DOI 10.1016/S1875-5364(17)30041-9
   WOSTMANN BS, 1983, LAB ANIM SCI, V33, P46
   Yang J, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0146946
   Zhong LJ, 2017, CHIN J NAT MEDICINES, V15, P210, DOI 10.1016/S1875-5364(17)30037-7
   Zhong YD, 2015, MOL NUTR FOOD RES, V59, P2066, DOI 10.1002/mnfr.201500187
   Zhou GC, 2001, J CLIN INVEST, V108, P1167, DOI 10.1172/JCI200113505
NR 58
TC 27
Z9 29
U1 1
U2 18
PU CHINESE JOURNAL NATURAL MEDICINES
PI NANJING
PA 24, TONGJIA XIANG, NANJING, 210009, PEOPLES R CHINA
SN 2095-6975
EI 1875-5364
J9 CHIN J NAT MEDICINES
JI Chin. J. Nat. Med.
PD NOV
PY 2019
VL 17
IS 11
BP 835
EP 841
PG 7
WC Integrative & Complementary Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine; Pharmacology & Pharmacy
GA JU7BD
UT WOS:000501827000004
PM 31831130
DA 2023-06-08
ER

PT J
AU Baker, JM
   Al-Nakkash, L
   Herbst-Kralovetz, MM
AF Baker, James M.
   Al-Nakkash, Layla
   Herbst-Kralovetz, Melissa M.
TI Estrogen gut microbiome axis: Physiological and clinical implications
SO MATURITAS
LA English
DT Review
DE Estrobolome; Phytoestrogen; Dysbiosis; Cancer; Fertility; Metabolic
   syndrome
ID BARIATRIC SURGERY; GLUCOSE-METABOLISM; ENDOMETRIAL HYPERPLASIA; SOY
   ISOFLAVONES; CANCER-RISK; WOMEN; RECEPTORS; OBESITY; SEX; METFORMIN
AB Low levels of gonadal circulating estrogen observed in post-menopausal women can adversely impact a diverse range of physiological factors, with clinical implications for brain cognition, gut health, the female reproductive tract and other aspects of women's health. One of the principal regulators of circulating estrogens is the gut microbiome. This review aims to shed light on the role of the gut microbiota in estrogen-modulated disease. The gut microbiota regulates estrogens through secretion of P-glucuronidase, an enzyme that deconjugates estrogens into their active forms. When this process is impaired through dysbiosis of gut microbiota, characterized by lower microbial diversity, the decrease in deconjugation results in a reduction of circulating estrogens. The alteration in circulating estrogens may contribute to the development of conditions discussed herein: obesity, metabolic syndrome, cancer, endometrial hyperplasia, endometriosis, polycystic ovary syndrome, fertility, cardiovascular disease (CVD) and cognitive function. The bi-directional relationship between the metabolic profile (including estrogen levels) and gut microbiota in estrogen-driven disease will also be discussed. Promising therapeutic interventions manipulating the gut microbiome and the metabolic profile of estrogen driven disease, such as bariatric surgery and metformin, will be detailed. Modulation of the microbiome composition subsequently impacts the metabolic profile, and vice versa, and has been shown to alleviate many of the estrogen-modulated disease states. Last, we highlight promising research interventions in the field, such as dietary therapeutics, and discuss areas that provide exciting unexplored topics of study.
C1 [Baker, James M.; Herbst-Kralovetz, Melissa M.] Univ Arizona, Coll Med Phoenix, Dept Basic Med Sci, Phoenix, AZ 85004 USA.
   [Baker, James M.] Univ Bath, Dept Biol & Biochem, Bath, Avon, England.
   [Al-Nakkash, Layla] Midwestern Univ, Arizona Coll Osteopath Med, Dept Physiol, Glendale, AZ USA.
   [Herbst-Kralovetz, Melissa M.] Univ Arizona, Coll Med Phoenix, Dept Obstet & Gynecol, Phoenix, AZ USA.
C3 University of Arizona; University of Bath; Midwestern University;
   University of Arizona
RP Herbst-Kralovetz, MM (通讯作者)，Univ Arizona, Coll Med Phoenix, Bldg ABC 1,Off 330,Lab 331E,425 North 5th St, Phoenix, AZ 85004 USA.
EM mherbst1@email.arizona.edu
RI Al-Nakkash, Layla/GLR-3517-2022
OI Baker, James M/0000-0002-0301-2002; Herbst-Kralovetz,
   Melissa/0000-0002-8540-5917
FU University of Arizona
FX This work was supported by the University of Arizona.
CR ANDERSON DC, 1974, CLIN ENDOCRINOL, V3, P69, DOI 10.1111/j.1365-2265.1974.tb03298.x
   Bailey MT, 2002, HUM REPROD, V17, P1704, DOI 10.1093/humrep/17.7.1704
   Brusselaers N., INT J CANC, V140
   Buchwald H, 2004, JAMA-J AM MED ASSOC, V292, P1724, DOI 10.1001/jama.292.14.1724
   Butterworth J., 2016, J OBEST, P2016
   Chan J. L., 2016, AM J OBSTET GYNECOL, P2017
   Charalampakis V, 2016, EUR J OBSTET GYN R B, V207, P220, DOI 10.1016/j.ejogrb.2016.10.001
   Christou NV, 2008, SURG OBES RELAT DIS, V4, P691, DOI 10.1016/j.soard.2008.08.025
   Damman CJ, 2012, AM J GASTROENTEROL, V107, P1452, DOI 10.1038/ajg.2012.93
   Day JC, 1996, CURRENT POPULATION R
   DEITCH EA, 1990, ARCH SURG-CHICAGO, V125, P403
   Dewi FN, 2012, J NUTR, V142, P1829, DOI 10.3945/jn.112.161711
   Epplein M, 2008, AM J EPIDEMIOL, V168, P563, DOI 10.1093/aje/kwn168
   Eyster KM, 2016, METHODS MOL BIOL, V1366, P1, DOI 10.1007/978-1-4939-3127-9_1
   Fang K, 2016, MOL NUTR FOOD RES, V60, P1602, DOI 10.1002/mnfr.201501024
   FELSON DT, 1993, NEW ENGL J MED, V329, P1141, DOI 10.1056/NEJM199310143291601
   Flores R, 2012, J TRANSL MED, V10, DOI 10.1186/1479-5876-10-253
   Forman D, 1996, SCAND J GASTROENTERO, V31, P23, DOI 10.3109/00365529609094746
   Frankenfeld CL, 2014, EUR J CLIN NUTR, V68, P526, DOI 10.1038/ejcn.2014.23
   Fu L., 2016, J CARDIOVASC PHARM, P2017
   Fuhrman BJ, 2014, J CLIN ENDOCR METAB, V99, P4632, DOI 10.1210/jc.2014-2222
   Fujishita A, 1997, FERTIL STERIL, V67, P856, DOI 10.1016/S0015-0282(97)81397-0
   Goenka L, 2017, BIOMED PHARMACOTHER, V90, P575, DOI 10.1016/j.biopha.2017.03.092
   GRADY D, 1995, OBSTET GYNECOL, V85, P304, DOI 10.1016/0029-7844(94)00383-O
   Greiner TU, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0110359
   Guo Y, 2016, PLASMONICS, V11, P11, DOI [10.1007/s11468-015-0008-1, 10.1371/journal.pone.0156323]
   Homma H, 2005, AM J PHYSIOL-GASTR L, V288, pG466, DOI 10.1152/ajpgi.00036.2004
   Hostalek U, 2015, DRUGS, V75, P1071, DOI 10.1007/s40265-015-0416-8
   Huang G, 2017, TOXICOL APPL PHARM
   Jones HE, 1933, GENET PSYCHOL MONOGR, V13, P223
   Kaska L, 2016, WORLD J GASTROENTERO, V22, P8698, DOI 10.3748/wjg.v22.i39.8698
   Kau AL, 2011, NATURE, V474, P327, DOI 10.1038/nature10213
   Khan KN, 2016, EUR J OBSTET GYN R B, V199, P69, DOI 10.1016/j.ejogrb.2016.01.040
   Kitawaki J, 2002, J STEROID BIOCHEM, V83, P149, DOI 10.1016/S0960-0760(02)00260-1
   Laaksonen DE, 2004, DIABETES CARE, V27, P1036, DOI 10.2337/diacare.27.5.1036
   Laschke MW, 2016, AM J OBSTET GYNECOL, V215, DOI 10.1016/j.ajog.2016.02.036
   Li J, 2017, MICROBIOME, V5, DOI 10.1186/s40168-016-0222-x
   Lindheim L, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0168390
   Lobo RA, 2000, ANN INTERN MED, V132, P989, DOI 10.7326/0003-4819-132-12-200006200-00010
   Markle JGM, 2013, SCIENCE, V339, P1084, DOI 10.1126/science.1233521
   Mauvais-Jarvis F, 2013, ENDOCR REV, V34, P309, DOI 10.1210/er.2012-1055
   McDonald SD, 2010, BMJ-BRIT MED J, V341, DOI 10.1136/bmj.c3428
   Muhleisen AL, 2016, MATURITAS, V91, P42, DOI 10.1016/j.maturitas.2016.05.015
   Panneerselvam S, 2016, J NUTR BIOCHEM, V38, P57, DOI 10.1016/j.jnutbio.2016.08.007
   Plottel CS, 2011, CELL HOST MICROBE, V10, P324, DOI 10.1016/j.chom.2011.10.003
   Ridlon JM, 2013, J LIPID RES, V54, P2437, DOI 10.1194/jlr.M038869
   Rietjens IMCM, 2016, BR J PHARM
   Riviere A, 2016, FRONT MICROBIOL, V7, DOI 10.3389/fmicb.2016.00979
   Schwabe RF, 2013, NAT REV CANCER, V13, P800, DOI 10.1038/nrc3610
   Seaman HE, 2008, BJOG-INT J OBSTET GY, V115, P1392, DOI 10.1111/j.1471-0528.2008.01879.x
   SIITERI PK, 1987, AM J CLIN NUTR, V45, P277, DOI 10.1093/ajcn/45.1.277
   Sommer F, 2013, NAT REV MICROBIOL, V11, P227, DOI 10.1038/nrmicro2974
   Thomas HV, 1997, CANCER CAUSE CONTROL, V8, P922, DOI 10.1023/A:1018476631561
   Tietjen GE, 2006, HEADACHE, V46, P422, DOI 10.1111/j.1526-4610.2006.00290.x
   TORANALLERAND CD, 1992, P NATL ACAD SCI USA, V89, P4668, DOI 10.1073/pnas.89.10.4668
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Upala S, 2015, SURG OBES RELAT DIS, V11, P949, DOI 10.1016/j.soard.2014.09.024
   Usui T, 2013, CLIN ENDOCRINOL, V78, P365, DOI 10.1111/j.1365-2265.2012.04400.x
   Vrieze A, 2012, GASTROENTEROLOGY, V143, P913, DOI 10.1053/j.gastro.2012.06.031
   Wang JJ, 2015, ISME J, V9, P1, DOI 10.1038/ismej.2014.99
   Xiao L., 2017, MICROBIOME, P5
   Zhang J, 2017, PAK J MED SCI, V33, P8, DOI 10.12669/pjms.331.11764
   Zhang Q, 2009, AM J OBSTET GYNECOL, V200, DOI 10.1016/j.ajog.2008.08.064
   Zhang YB, 2013, NUTRITION, V29, P8, DOI 10.1016/j.nut.2012.03.019
NR 64
TC 322
Z9 335
U1 11
U2 111
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-5122
EI 1873-4111
J9 MATURITAS
JI Maturitas
PD SEP
PY 2017
VL 103
BP 45
EP 53
DI 10.1016/j.maturitas.2017.06.025
PG 9
WC Geriatrics & Gerontology; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Obstetrics & Gynecology
GA FD6UR
UT WOS:000407663900008
PM 28778332
OA Bronze
HC Y
HP N
DA 2023-06-08
ER

PT J
AU Montenegro, RM
   Ponte, CMM
   Castelo, MHCG
   Silveira, ACD
   Fernandes, VO
   D'Alva, CB
   Oliveira, LFV
   Hristov, AD
   Bandeira, SP
   Paiva, GED
   Levi, JE
AF Montenegro, Renan Magalhaes, Jr.
   Melo Ponte, Clarisse Mourao
   Costa Gurgel Castelo, Maria Helane
   de Oliveira Silveira, Alessandro Conrado
   Fernandes, Virginia Oliveira
   D'Alva, Catarina Brasil
   Valter Oliveira, Luiz Felipe
   Hristov, Angelica Domingues
   Bandeira, Silviane Praciano
   da Cruz Paiva, Grayce Ellen
   Levi, Jose Eduardo
TI Reduced gut microbiota diversity in patients with congenital generalized
   lipodystrophy
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
DE Gut microbiota; Diabetes; Lipodystrophy
ID LEPTIN RECEPTOR; OBESITY; DIET; DYSBIOSIS; METFORMIN; CLASSIFICATION;
   ADIPONECTIN; MOTILITY; ALTERS; IMPACT
AB Background Previous studies suggest intestinal dysbiosis is associated with metabolic diseases. However, the causal relationship between them is not fully elucidated. Gut microbiota evaluation of patients with congenital generalized lipodystrophy (CGL), a disease characterized by the absence of subcutaneous adipose tissue, insulin resistance, and diabetes since the first years of life, could provide insights into these relationships. Methods A cross-sectional study was conducted with patients with CGL (n = 17) and healthy individuals (n = 17). The gut microbiome study was performed by sequencing the 16S rRNA gene through High-Throughput Sequencing (BiomeHub Biotechnologies, Brazil). Results The median age was 20.0 years old, and 64.7% were female. There was no difference between groups in pubertal stage, BMI, ethnicity, origin (rural or urban), delivery, breastfeeding, caloric intake, macronutrient, or fiber consumption. Lipodystrophic patients presented a lower alpha diversity (Richness index: 54.0 versus 67.5; p = 0.008). No differences were observed in the diversity parameters when analyzing the presence of diabetes, its complications, or the CGL subtype. Conclusion In this study, we demonstrate for the first time a reduced gut microbiota diversity in individuals with CGL. Dysbiosis was present despite dietary treatment and was also observed in young patients. Our findings allow us to speculate that the loss of intestinal microbiota diversity may be due to metabolic abnormalities present since the first years of life in CGL. Longitudinal studies are needed to confirm these findings, clarifying the possible causal link between dysbiosis and insulin resistance in humans.
C1 [Montenegro, Renan Magalhaes, Jr.; Melo Ponte, Clarisse Mourao; Costa Gurgel Castelo, Maria Helane; Fernandes, Virginia Oliveira; D'Alva, Catarina Brasil; da Cruz Paiva, Grayce Ellen] Fed Univ Ceara Ebserh, Univ Hosp, Fortaleza, CE, Brazil.
   [Melo Ponte, Clarisse Mourao; Costa Gurgel Castelo, Maria Helane; de Oliveira Silveira, Alessandro Conrado; Hristov, Angelica Domingues; Bandeira, Silviane Praciano; Levi, Jose Eduardo] DASA, Sao Paulo, SP, Brazil.
   [de Oliveira Silveira, Alessandro Conrado] Univ Reg Blumenau, Blumenau, SC, Brazil.
   [Valter Oliveira, Luiz Felipe] BiomeHub, Florianopolis, SC, Brazil.
   [Melo Ponte, Clarisse Mourao; Costa Gurgel Castelo, Maria Helane] Christus Univ Ctr, Fortaleza, CE, Brazil.
C3 Universidade Regional de Blumenau (FURB)
RP Ponte, CMM (通讯作者)，Fed Univ Ceara Ebserh, Univ Hosp, Fortaleza, CE, Brazil.; Ponte, CMM (通讯作者)，DASA, Sao Paulo, SP, Brazil.; Ponte, CMM (通讯作者)，Christus Univ Ctr, Fortaleza, CE, Brazil.
EM clarisse.ponte@unicrhistus.edu.br
FU INCT (National Institute of Science and Technology) for Diabetes and
   Obesity - CNPq [465693/2014-8]; FAPESP [2014/50907-5]; BiomeHub; DASA,
   Brazil
FX This work was supported by INCT (National Institute of Science and
   Technology) for Diabetes and Obesity - CNPq Grant number 465693/2014-8
   and FAPESP Grant number 2014/50907-5. This work was partially supported
   by BiomeHub and DASA, Brazil.
CR Akinci B, 2016, J CLIN ENDOCR METAB, V101, P2759, DOI 10.1210/jc.2016-1005
   Akinci B, 2019, J CLIN ENDOCR METAB, V104, P5117, DOI 10.1210/jc.2018-02730
   ALTSCHUL SF, 1990, J MOL BIOL, V215, P403, DOI 10.1006/jmbi.1990.9999
   Amir A, 2017, MSYSTEMS, V2, DOI 10.1128/mSystems.00191-16
   Bado A, 1998, NATURE, V394, P790, DOI 10.1038/29547
   Bauer PV, 2016, CELL MOL LIFE SCI, V73, P737, DOI 10.1007/s00018-015-2083-z
   Bonaz B, 2018, FRONT NEUROSCI-SWITZ, V12, DOI 10.3389/fnins.2018.00049
   Cani PD, 2016, MOL METAB, V5, P743, DOI 10.1016/j.molmet.2016.05.011
   Caporaso JG, 2012, ISME J, V6, P1621, DOI 10.1038/ismej.2012.8
   Cefalu WT, 2019, DIABETES CARE, V42, pS13, DOI 10.2337/dc19-S002
   Cho I, 2012, NAT REV GENET, V13, P260, DOI 10.1038/nrg3182
   Christoff AP, 2019, bioRxiv, DOI [10.1101/646349, DOI 10.1101/646349]
   Cox AJ, 2015, LANCET DIABETES ENDO, V3, P207, DOI 10.1016/S2213-8587(14)70134-2
   Cruz GNF, 2021, FRONT MICROBIOL, V12, DOI 10.3389/fmicb.2021.638231
   Dao MC, 2016, GUT, V65, P426, DOI 10.1136/gutjnl-2014-308778
   De Bandt JP, 2011, CURR OPIN CLIN NUTR, V14, P334, DOI 10.1097/MCO.0b013e328347924a
   De Silva A, 2012, GUT LIVER, V6, P10, DOI 10.5009/gnl.2012.6.1.10
   Diez JJ, 2003, EUR J ENDOCRINOL, V148, P293, DOI 10.1530/eje.0.1480293
   Dockray GJ, 2013, CURR OPIN PHARMACOL, V13, P954, DOI 10.1016/j.coph.2013.09.007
   Ducroc R, 2005, DIABETES, V54, P348, DOI 10.2337/diabetes.54.2.348
   Duggal P, 2011, J CLIN INVEST, V121, P1191, DOI 10.1172/JCI45294
   Duncan SH, 2008, INT J OBESITY, V32, P1720, DOI 10.1038/ijo.2008.155
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Garg A, 2000, AM J MED, V108, P143, DOI 10.1016/S0002-9343(99)00414-3
   Geurts L, 2011, FRONT MICROBIOL, V2, DOI 10.3389/fmicb.2011.00149
   Grases-Pinto B, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.02369
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Hsieh MC, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-35014-1
   Iebba V, 2016, NEW MICROBIOL, V39, P1
   Ito D, 1993, GENEREVIEWS
   Jost Lou, 2011, P66
   Kiely JM, 2005, J SURG RES, V124, P98, DOI 10.1016/j.jss.2004.10.005
   Kim BR, 2017, J MICROBIOL BIOTECHN, V27, P2089, DOI 10.4014/jmb.1709.09027
   Kim KA, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0047713
   Klingbeil E, 2018, AM J PHYSIOL-REG I, V315, pR1254, DOI 10.1152/ajpregu.00037.2018
   Le Chatelier E, 2013, NATURE, V500, P541, DOI 10.1038/nature12506
   Ley RE, 2005, P NATL ACAD SCI USA, V102, P11070, DOI 10.1073/pnas.0504978102
   Ley RE, 2006, NATURE, V444, P1022, DOI 10.1038/4441022a
   Luoto R, 2010, INT J OBESITY, V34, P1531, DOI 10.1038/ijo.2010.50
   Magne F, 2020, NUTRIENTS, V12, DOI 10.3390/nu12051474
   Martinez V, 1999, NEUROREPORT, V10, P3217, DOI 10.1097/00001756-199910190-00017
   Ponte CMM, 2018, BMC CARDIOVASC DISOR, V18, DOI 10.1186/s12872-017-0738-4
   Moshfegh AJ, 2008, AM J CLIN NUTR, V88, P324
   National High Blood Pressure Education Program, 2004, 7 NAT HEART LUNG BLO
   Osadchiy V, 2019, CLIN GASTROENTEROL H, V17, P322, DOI 10.1016/j.cgh.2018.10.002
   Park HJ, 2015, J VET INTERN MED, V29, P43, DOI 10.1111/jvim.12455
   Patil DP, 2012, J BIOSCIENCES, V37, P647, DOI 10.1007/s12038-012-9244-0
   Patni N, 2015, NAT REV ENDOCRINOL, V11, P522, DOI 10.1038/nrendo.2015.123
   Pedret A, 2019, INT J OBESITY, V43, P1863, DOI 10.1038/s41366-018-0220-0
   Petersen C, 2014, CELL MICROBIOL, V16, P1024, DOI 10.1111/cmi.12308
   Porter EM, 2002, CELL MOL LIFE SCI, V59, P156, DOI 10.1007/s00018-002-8412-z
   Rajala MW, 2014, ENDOCRINOLOGY, V155, P748, DOI 10.1210/en.2013-1085
   Rodriguez J, 2018, CURR OPIN CLIN NUTR, V21, P294, DOI 10.1097/MCO.0000000000000468
   Rognes T, 2016, PEERJ, V4, DOI 10.7717/peerj.2584
   Rozman V, 2020, INT J FOOD MICROBIOL, V314, DOI 10.1016/j.ijfoodmicro.2019.108388
   Salminen MK, 2002, CLIN INFECT DIS, V35, P1155, DOI 10.1086/342912
   Salzman NH, 2010, NAT IMMUNOL, V11, P76, DOI 10.1038/ni.1825
   Schwiertz A, 2010, OBESITY, V18, P190, DOI 10.1038/oby.2009.167
   Sen T, 2017, PHYSIOL BEHAV, V173, P305, DOI 10.1016/j.physbeh.2017.02.027
   Sobhani I, 2000, GUT, V47, P178, DOI 10.1136/gut.47.2.178
   Sze MA, 2016, MBIO, V7, DOI 10.1128/mBio.01018-16
   Tanner J, 1962, GROWTH ADOLESCENCE
   Thaiss CA, 2018, SCIENCE, V359, P1376, DOI 10.1126/science.aar3318
   Turnbaugh PJ, 2007, NATURE, V449, P804, DOI 10.1038/nature06244
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Turnbaugh PJ, 2009, NATURE, V457, P480, DOI 10.1038/nature07540
   Wang Y, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0007401
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Yang G, 2021, METABOLISM, V117, DOI 10.1016/j.metabol.2021.154712
   Yarandi SS, 2014, NEUROGASTROENT MOTIL, V26, P611, DOI 10.1111/nmo.12330
   Yarandi SS, 2011, NUTRITION, V27, P269, DOI 10.1016/j.nut.2010.07.004
   Yarza P, 2014, NAT REV MICROBIOL, V12, P635, DOI 10.1038/nrmicro3330
   Zhang JJ, 2009, BRIT J PHARMACOL, V158, P475, DOI 10.1111/j.1476-5381.2009.00246.x
   Zhang Q, 2020, DIABET METAB SYND OB, V13, P5003, DOI 10.2147/DMSO.S286430
   ZHANG YY, 1994, NATURE, V372, P425, DOI 10.1038/372425a0
   Zou YC, 2020, FOOD FUNCT, V11, P2406, DOI 10.1039/c9fo01524h
NR 76
TC 1
Z9 1
U1 6
U2 7
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD SEP 24
PY 2022
VL 14
IS 1
AR 136
DI 10.1186/s13098-022-00908-8
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 4T0OS
UT WOS:000857828900001
PM 36153588
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Zhao, JD
   Li, Y
   Sun, M
   Yu, CJ
   Li, JY
   Wang, SH
   Yang, D
   Guo, CL
   Du, X
   Zhang, WJ
   Cheng, RD
   Diao, XC
   Fang, ZH
AF Zhao, Jin-Dong
   Li, Yan
   Sun, Min
   Yu, Chan-Juan
   Li, Jia-Yun
   Wang, Si-Hai
   Yang, Di
   Guo, Cheng-Lin
   Du, Xue
   Zhang, Wen-Jin
   Cheng, Ruo-Dong
   Diao, Xiao-Chuan
   Fang, Zhao-Hui
TI Effect of berberine on hyperglycaemia and gut microbiota composition in
   type 2 diabetic Goto-Kakizaki rats
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Article
DE Type 2 diabetes mellitus; Amelioration of hyperglycaemia; Modulation of
   gut microbiota; Berberine; Metformin; Goto-Kakizaki rats
ID BETA-CELL; GK RAT; METFORMIN; SAFETY; PATHOGENESIS; AKKERMANSIA;
   METAGENOME; MELLITUS
AB BACKGROUND
   A recent investigation showed that the prevalence of type 2 diabetes mellitus (T2DM) is 12.8% among individuals of Han ethnicity. Gut microbiota has been reported to play a central role in T2DM. Goto-Kakizaki (GK) rats show differences in gut microbiota compared to non-diabetic rats. Previous studies have indicated that berberine could be successfully used to manage T2DM. We sought to understand its hypoglycaemic effect and role in the regulation of the gut microbiota.
   AIM
   To determine whether berberine can regulate glucose metabolism in GK rats via the gut microbiota.
   METHODS
   GK rats were acclimatized for 1 wk. The GK rats were randomly divided into three groups and administered saline (Mo), metformin (Me), or berberine (Be). The observation time was 8 wk, and weight, fasting blood glucose (FBG), insulin, and glucagon-like peptide-1 (GLP-1) were measured. Pancreatic tissue was observed for pathological changes. Additionally, we sequenced the 16S rRNA V3-V4 region of the gut microbiota and analysed the structure.
   RESULTS
   Compared with the Mo group, the Me and Be groups displayed significant differences in FBG (P < 0.01) and GLP-1 (P < 0.05). A significant decrease in weight and homeostatic model assessment-insulin resistance was noted in the Be group compared with those in the Me group (P < 0.01). The pancreatic islets of the Me- and Be-treated rats showed improvement in number, shape, and necrosis compared with those of Mo-treated rats. A total of 580 operational taxonomic units were obtained in the three groups. Compared to the Mo group, the Me and Be groups showed a shift in the structure of the gut microbiota. Correlation analysis indicated that FBG was strongly positively correlated with Clostridia_UCG-014 (P < 0.01) and negatively correlated with Allobaculum (P < 0.01). Body weight showed a positive correlation with Desulfovibrionaceae (P < 0.01) and a negative correlation with Akkermansia (P < 0.01). Importantly, our results demonstrated that Me and Be could significantly decrease Bacteroidetes (P < 0.01) and the Bacteroidetes/Firmicutes ratio (P < 0.01). Furthermore, Muribaculaceae (P < 0.01; P < 0.05) was significantly decreased in the Me and Be groups, and Allobaculum (P < 0.01) was significantly increased.
   CONCLUSION
   Berberine has a substantial effect in improving metabolic parameters and modulating the gut microbiota composition in T2DM rats.
C1 [Zhao, Jin-Dong; Yu, Chan-Juan; Li, Jia-Yun; Wang, Si-Hai; Yang, Di; Guo, Cheng-Lin; Du, Xue; Zhang, Wen-Jin; Cheng, Ruo-Dong; Diao, Xiao-Chuan; Fang, Zhao-Hui] Anhui Univ Chinese Med, Affiliated Hosp 1, Dept Endocrinol, 117 Meishan Rd, Hefei 230031, Anhui, Peoples R China.
   [Li, Yan] Anhui Univ Chinese Med, Affiliated Hosp 1, Dept Infect Dis, Hefei 230031, Anhui, Peoples R China.
   [Sun, Min] Anhui Univ, Sch Life Sci, Hefei 230039, Anhui, Peoples R China.
C3 Anhui University of Chinese Medicine; Anhui University of Chinese
   Medicine; Anhui University
RP Fang, ZH (通讯作者)，Anhui Univ Chinese Med, Affiliated Hosp 1, Dept Endocrinol, 117 Meishan Rd, Hefei 230031, Anhui, Peoples R China.
EM fangzhaohui1111@163.com
RI SUN, MIN/GQZ-7245-2022
FU National Natural Science Foundation of China [81603574, 81774286];
   National Key Research and Development Program [2018YFC1704202,
   2020YFE0201800]; University Scientific Research Projects of Anhui
   [KJ2020A0401, KJ2019A0442]; Province Science Foundation of Anhui
   [1708085QH213]
FX Supported by National Natural Science Foundation of China, No. 81603574
   and No. 81774286; National Key Research and Development Program, No.
   2018YFC1704202 and No. 2020YFE0201800; University Scientific Research
   Projects of Anhui, No. KJ2020A0401 and No. KJ2019A0442; and Province
   Science Foundation of Anhui, No. 1708085QH213.
CR Amato KR, 2013, ISME J, V7, P1344, DOI 10.1038/ismej.2013.16
   Burcelin R, 2011, ACTA DIABETOL, V48, P257, DOI 10.1007/s00592-011-0333-6
   Cui HX, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/8930374
   Dai PF, 2015, EXP THER MED, V10, P869, DOI 10.3892/etm.2015.2585
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Dong J, 2020, INT J BIOL MACROMOL, V159, P725, DOI 10.1016/j.ijbiomac.2020.05.042
   Ehses JA, 2009, P NATL ACAD SCI USA, V106, P13998, DOI 10.1073/pnas.0810087106
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Ferrannini E, 2009, DIABETES OBES METAB, V11, P157, DOI 10.1111/j.1463-1326.2008.00994.x
   Gao K, 2018, PHARMACOL RES, V130, P93, DOI 10.1016/j.phrs.2018.01.011
   Goto Y, 1988, Adv Exp Med Biol, V246, P29
   Graham GG, 2011, CLIN PHARMACOKINET, V50, P81, DOI 10.2165/11534750-000000000-00000
   Jung CH, 2005, J ETHNOPHARMACOL, V98, P245, DOI 10.1016/j.jep.2004.12.030
   Kahn SE, 2003, DIABETOLOGIA, V46, P3, DOI 10.1007/s00125-002-1009-0
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Lan JR, 2015, J ETHNOPHARMACOL, V161, P69, DOI 10.1016/j.jep.2014.09.049
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Li JW, 2017, J FUNCT FOODS, V38, P399, DOI 10.1016/j.jff.2017.09.031
   Li LY, 2020, GUT MICROBES, V11, P1348, DOI 10.1080/19490976.2020.1755413
   Li TG, 2013, DRUG METAB REV, V45, P145, DOI 10.3109/03602532.2012.740048
   Li YZ, 2020, BMJ-BRIT MED J, V369, DOI 10.1136/bmj.m997
   Liu DQ, 2017, LWT-FOOD SCI TECHNOL, V86, P40, DOI 10.1016/j.lwt.2017.07.040
   Liu GM, 2018, MOL NUTR FOOD RES, V62, DOI 10.1002/mnfr.201700954
   Lu F, 1996, ENDOCRINOLOGY, V137, P3710, DOI 10.1210/en.137.9.3710
   Martinez N, 2011, DIABETES-METAB RES, V27, P35, DOI 10.1002/dmrr.1151
   Miller RA, 2010, J CLIN INVEST, V120, P2267, DOI 10.1172/JCI43661
   Movassat J, 2007, DIABETES OBES METAB, V9, P187, DOI 10.1111/j.1463-1326.2007.00786.x
   Portha B, 2009, MOL CELL ENDOCRINOL, V297, P73, DOI 10.1016/j.mce.2008.06.013
   Portha B, 2001, DIABETES, V50, pS89, DOI 10.2337/diabetes.50.2007.S89
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Roediger WEW, 1997, DIGEST DIS SCI, V42, P1571, DOI 10.1023/A:1018851723920
   Shin NR, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.02271
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Sogin EM, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0111274
   Tanaka T, 2008, N-S ARCH PHARMACOL, V377, P515, DOI 10.1007/s00210-007-0250-y
   Tian Y, 2019, DRUG METAB DISPOS, V47, P86, DOI 10.1124/dmd.118.083691
   Tong XL, 2013, DIABETES OBES METAB, V15, P448, DOI 10.1111/dom.12051
   Turner N, 2008, DIABETES, V57, P1414, DOI 10.2337/db07-1552
   Wang LL, 2017, J CHROMATOGR B, V1057, P70, DOI 10.1016/j.jchromb.2017.05.004
   Wang YS, 2019, MEDICINE, V98, DOI 10.1097/MD.0000000000016947
   Wang ZK, 2014, WORLD J GASTROENTERO, V20, P14805, DOI 10.3748/wjg.v20.i40.14805
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Xie WD, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0024520
   Zhang CC, 2019, FOOD FUNCT, V10, P3252, DOI [10.1039/C9FO00119K, 10.1039/c9fo00119k]
   Zhang W, 2019, BIOMED PHARMACOTHER, V118, DOI 10.1016/j.biopha.2019.109131
   Zhang X, 2012, PLOS ONE, V7, DOI [10.1371/journal.pone.0040320, 10.1371/journal.pone.0042529]
   Zhang X, 2015, SCI REP-UK, V5, DOI 10.1038/srep14405
   Zhao JD, 2020, EVID-BASED COMPL ALT, V2020, DOI 10.1155/2020/5795264
   Zhao JD, 2019, EVID-BASED COMPL ALT, V2019, DOI 10.1155/2019/6976394
   Zhao L, 2017, FOOD FUNCT, V8, P4644, DOI [10.1039/c7fo01383c, 10.1039/C7FO01383C]
   Zhu L, 2018, ATHEROSCLEROSIS, V268, P117, DOI 10.1016/j.atherosclerosis.2017.11.023
NR 52
TC 25
Z9 26
U1 7
U2 39
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD FEB 28
PY 2021
VL 27
IS 8
BP 708
EP 724
DI 10.3748/wjg.v27.i8.708
PG 17
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA QV3PN
UT WOS:000627887300004
PM 33716449
OA hybrid, Green Published
DA 2023-06-08
ER

PT J
AU Zou, B
   Yang, WL
   Tang, Y
   Hou, YF
   Tang, TT
   Qu, SL
AF Zou, Bu
   Yang, Wenling
   Tang, Ying
   Hou, Yangfeng
   Tang, Tingting
   Qu, Shunlin
TI Intestinal microbiota-farnesoid X receptor axis in metabolic diseases
SO CLINICA CHIMICA ACTA
LA English
DT Review
DE Intestinal microbiota; Farnesoid X receptor; Metabolic disease; Bile
   salt hydrolase; Metformin
ID BILE-ACID METABOLISM; GUT MICROBIOTA; FXR; MICE; STEATOHEPATITIS;
   DEFICIENCY; CROSSTALK; IMPACT
AB Studies have demonstrated that intestinal microbiota is associated with various metabolic diseases including obesity, nonalcoholic fatty liver, and insulin resistance. Farnesoid X receptor (FXR), also known as the bile acid receptor, belongs to the nuclear receptor superfamily, which is involved in the regulation of bile acid, glucose, and lipid metabolism. Researchers have found that intestinal microbiota can regulate FXR activity by affecting bile acid composition, and then regulate the balance of in vivo metabolism. The intestinal microbiota-FXR axis may be an ideal drug target for metabolic diseases. This review summarizes the latest research on the intestinal microbiota /FXR axis, hoping to provide a theoretical basis for further research and clinical application.
C1 [Zou, Bu; Yang, Wenling; Tang, Ying; Hou, Yangfeng; Tang, Tingting; Qu, Shunlin] Univ South China, Inst Cardiovasc Dis, Hunan Int Sci & Technol Cooperat Base Arterioscle, Key Lab Arteriosclerol Hunan Prov,Pathophysiol De, Hengyang City 421001, Hunan, Peoples R China.
   [Zou, Bu; Tang, Ying; Hou, Yangfeng] Univ South China, Hengyang Med Coll, Clin Dept, Hengyang City 421001, Hunan, Peoples R China.
   [Yang, Wenling] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Cardiol, Wuhan 430022, Peoples R China.
C3 University of South China; University of South China; Huazhong
   University of Science & Technology
RP Qu, SL (通讯作者)，Univ South China, Inst Cardiovasc Dis, Hunan Int Sci & Technol Cooperat Base Arterioscle, Key Lab Arteriosclerol Hunan Prov,Pathophysiol De, Hengyang City 421001, Hunan, Peoples R China.
EM qushunlin78@126.com
OI Hou, Yangfeng/0000-0002-5341-7999; Zou, Bu/0000-0003-4609-5917
FU National Natural Science Foundation of China [81670424]; Key Scientific
   Research Fund of Hunan Provincial Education Department [15A166];
   Scientific Research Fund of Hunan Provincial Health and Family Planning
   Commission [B2016087]; Hunan College Students Innovation and
   Entrepreneurship Training Program [S20191055035, X2019131]; project of
   State Administration of Work Safety [hunan-0013-2016AQ]
FX This work was supported by grants from the National Natural Science
   Foundation of China (81670424), the Key Scientific Research Fund of
   Hunan Provincial Education Department (15A166), the Scientific Research
   Fund of Hunan Provincial Health and Family Planning Commission
   (B2016087), the project of State Administration of Work Safety
   (hunan-0013-2016AQ) and the Hunan College Students Innovation and
   Entrepreneurship Training Program (S20191055035; X2019131).
CR Bertolini A, 2019, AM J PHYSIOL-GASTR L, V316, pG404, DOI 10.1152/ajpgi.00188.2018
   Blachnio-Zabielska AU, 2012, OBESITY, V20, P2341, DOI 10.1038/oby.2012.126
   Cheng QQ, 2015, MOL ENDOCRINOL, V29, P571, DOI 10.1210/me.2014-1337
   Degirolamo C, 2015, HEPATOLOGY, V61, P161, DOI 10.1002/hep.27274
   Dumas ME, 2006, P NATL ACAD SCI USA, V103, P12511, DOI 10.1073/pnas.0601056103
   Fang S, 2015, NAT MED, V21, P159, DOI 10.1038/nm.3760
   Hou YF, 2019, CLIN CHIM ACTA, V495, P29, DOI 10.1016/j.cca.2019.03.1626
   Jiang CT, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms10166
   Jiang CT, 2015, J CLIN INVEST, V125, P386, DOI 10.1172/JCI76738
   Kahrstrom CT, 2016, NATURE, V535, P47, DOI 10.1038/535047a
   Li F, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms3384
   Li MSY, 2019, INT J ENDOCRINOL, V2019, DOI 10.1155/2019/3248527
   Maran RRM, 2009, J PHARMACOL EXP THER, V328, P469, DOI 10.1124/jpet.108.145409
   Napolitano A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100778
   Neuschwander-Tetri BA, 2015, LANCET, V385, P956, DOI 10.1016/S0140-6736(14)61933-4
   Nobili V, 2018, ARCH MED SCI, V14, P81, DOI 10.5114/aoms.2016.62150
   Oellgaard J, 2017, CURR PHARM DESIGN, V23, P3699, DOI 10.2174/1381612823666170622095324
   Park MY, 2016, J APPL MICROBIOL, V121, P800, DOI 10.1111/jam.13158
   Parseus A, 2017, GUT, V66, P429, DOI 10.1136/gutjnl-2015-310283
   Pathak P, 2018, HEPATOLOGY, V68, P1574, DOI 10.1002/hep.29857
   Prawitt J, 2011, DIABETES, V60, P1861, DOI 10.2337/db11-0030
   Promrat K, 2011, HEPATOL RES, V41, P754, DOI 10.1111/j.1872-034X.2011.00815.x
   Raichur S, 2014, CELL METAB, V20, P687, DOI 10.1016/j.cmet.2014.09.015
   Rodrigues RR, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.02306
   Sayin SI, 2013, CELL METAB, V17, P225, DOI 10.1016/j.cmet.2013.01.003
   Schmitt J, 2015, LIVER INT, V35, P1133, DOI 10.1111/liv.12456
   Shin DJ, 2009, J BIOL CHEM, V284, P11110, DOI 10.1074/jbc.M808747200
   Su HY, 2012, AM J PHYSIOL-GASTR L, V303, pG1245, DOI 10.1152/ajpgi.00439.2011
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Sun RB, 2017, MOL PHARMACOL, V91, P110, DOI 10.1124/mol.116.106617
   Tanaka H, 1999, J DAIRY SCI, V82, P2530, DOI 10.3168/jds.S0022-0302(99)75506-2
   Tian Y, 2019, DRUG METAB DISPOS, V47, P86, DOI 10.1124/dmd.118.083691
   Turpin SM, 2014, CELL METAB, V20, P678, DOI 10.1016/j.cmet.2014.08.002
   Wahlstrom A, 2017, DIGEST DIS, V35, P246, DOI 10.1159/000450982
   Wahlstrom A, 2016, CELL METAB, V24, P41, DOI 10.1016/j.cmet.2016.05.005
   Wang WD, 2020, NUTR METAB, V17, DOI 10.1186/s12986-020-00442-2
   Wei ML, 2020, EBIOMEDICINE, V55, DOI 10.1016/j.ebiom.2020.102766
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Xie C, 2017, DIABETES, V66, P613, DOI 10.2337/db16-0663
   Yamato M, 2016, REDOX BIOL, V8, P316, DOI 10.1016/j.redox.2016.02.007
   Yang F, 2007, CANCER RES, V67, P863, DOI 10.1158/0008-5472.CAN-06-1078
NR 41
TC 5
Z9 5
U1 3
U2 32
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0009-8981
EI 1873-3492
J9 CLIN CHIM ACTA
JI Clin. Chim. Acta
PD OCT
PY 2020
VL 509
BP 167
EP 171
DI 10.1016/j.cca.2020.06.006
PG 5
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA NK4YF
UT WOS:000566737800026
PM 32505776
DA 2023-06-08
ER

PT J
AU Gouaref, I
   Detaille, D
   Wiernsperger, N
   Khan, NA
   Leverve, X
   Koceir, EA
AF Gouaref, Ines
   Detaille, Dominique
   Wiernsperger, Nicolas
   Khan, Naim Akhtar
   Leverve, Xavier
   Koceir, Elhadj-Ahmed
TI The desert gerbil Psammomys obesus as a model for metformin-sensitive
   nutritional type 2 diabetes to protect hepatocellular metabolic damage:
   Impact of mitochondrial redox state
SO PLOS ONE
LA English
DT Article
ID BETA-CELL FUNCTION; FATTY-ACID; GLUCOSE-6-PHOSPHATE HYDROLYSIS;
   GLUCOSE-PRODUCTION; GUT MICROBIOTA; BODY-WEIGHT; FOOD-INTAKE; RATS;
   GLUCONEOGENESIS; INSULIN
AB Introduction
   While metformin (MET) is the most widely prescribed antidiabetic drug worldwide, its beneficial effects in Psammomys obesus (P. obesus), a rodent model that mimics most of the metabolic features of human diabetes, have not been explored thoroughly. Here, we sought to investigate whether MET might improve insulin sensitivity, glucose homeostasis, lipid profile as well as cellular redox and energy balance in P. obesus maintained on a high energy diet (HED).
   Materials and methods
   P. obesus gerbils were randomly assigned to receive either a natural diet (ND) consisting of halophytic plants (control group) or a HED (diabetic group) for a period of 24 weeks. MET (50 mg/kg per os) was administered in both animal groups after 12 weeks of feeding, i.e., the time required for the manifestation of insulin resistance in P. obesus fed a HED. Parallel in vitro experiments were conducted on isolated hepatocytes that were shortly incubated (30 min) with MET and energetic substrates (lactate + pyruvate or alanine, in the presence of octanoate).
   Results
   In vivo, MET lowered glycemia, glycosylated haemoglobin, circulating insulin and fatty acid levels in diabetic P. obesus. It also largely reversed HED-induced hepatic lipid alterations. In vitro, MET increased glycolysis but decreased both gluconeogenesis and ketogenesis in the presence of glucogenic precursors and medium-chain fatty acid. Importantly, these changes were associated with an increase in cytosolic and mitochondrial redox states along with a decline in respiration capacity.
   Conclusions
   MET prevents the progression of insulin resistance in diabetes-prone P. obesus, possibly through a tight control of gluconeogenesis and fatty acid beta-oxidation depending upon mitochondrial function. While the latter is increasingly becoming a therapeutic issue in diabetes, the gut microbiota is another promising target that would need to be considered as well.
C1 [Gouaref, Ines; Koceir, Elhadj-Ahmed] Univ Sci & Technol Houari Boumediene, Bioenerget & Intermediary Metab Team, Lab Biol & Organism Physiol, Inst Biol Sci, BP 32, Algiers, Algeria.
   [Detaille, Dominique] Univ Bordeaux, Rhythmol & Heart Modeling Inst, Bordeaux, France.
   [Wiernsperger, Nicolas] INSERM, U1060, CarMeN Lab, Villeurbanne, France.
   [Khan, Naim Akhtar] UBFC, Physiol Nutr & Toxicol, INSERM, U1236, Dijon, France.
   [Leverve, Xavier] Univ Grenoble Alpes, LBFA, INSERM, U1055, Grenoble, France.
C3 University Science & Technology Houari Boumediene; UDICE-French Research
   Universities; Universite de Bordeaux; Institut National de la Sante et
   de la Recherche Medicale (Inserm); UDICE-French Research Universities;
   Universite Claude Bernard Lyon 1; Institut Agro; AgroSup Dijon; Institut
   National de la Sante et de la Recherche Medicale (Inserm); Universite de
   Bourgogne; Institut National de la Sante et de la Recherche Medicale
   (Inserm); UDICE-French Research Universities; Communaute Universite
   Grenoble Alpes; Universite Grenoble Alpes (UGA)
RP Koceir, EA (通讯作者)，Univ Sci & Technol Houari Boumediene, Bioenerget & Intermediary Metab Team, Lab Biol & Organism Physiol, Inst Biol Sci, BP 32, Algiers, Algeria.
EM e.koceir@gmail.com
OI KOCEIR, Elhadj-Ahmed/0000-0003-1345-2535; Khan, Naim
   Akhtar/0000-0002-8930-9332
FU German Federal Ministry of Education and Research (BMBF) [01EZ0816,
   01EZ0818, 13EZ0817]; Deutsche Herzstiftung e.V. [S/05/12]
FX This work was financially supported by a grant from the German Federal
   Ministry of Education and Research (BMBF; grant-ID 01EZ0816, 01EZ0818
   and 13EZ0817), and in part by the Deutsche Herzstiftung e.V. (S/05/12,
   Y-X, Ye). The funders had no role in study design, data collection and
   analysis, decision to publish, or preparation of the manuscript.
CR ARGAUD D, 1993, EUR J BIOCHEM, V213, P1341, DOI 10.1111/j.1432-1033.1993.tb17886.x
   Arora T, 2016, J INTERN MED, V280, P339, DOI 10.1111/joim.12508
   Atek-Mebarki F, 2015, BIOCHIMIE, V109, P60, DOI 10.1016/j.biochi.2014.12.004
   Bailey CJ, 2008, DIABETOLOGIA, V51, P1552, DOI 10.1007/s00125-008-1053-5
   Bergmeyer H.I., 1974, METHODS ENZYMATIC AN
   BERRY MN, 1969, J CELL BIOL, V43, P506, DOI 10.1083/jcb.43.3.506
   Boucaud-Maitre D, 2016, DIABETIC MED, V33, P1536, DOI 10.1111/dme.13098
   Bouderba S, 2014, J DIABETES, V6, P184, DOI 10.1111/1753-0407.12083
   Bouderba S, 2012, EXP DIABETES RES, DOI 10.1155/2012/430176
   BRANDES R, 1986, COMP BIOCHEM PHYS B, V83, P837, DOI 10.1016/0305-0491(86)90156-2
   Buse JB, 2016, DIABETES CARE, V39, P198, DOI 10.2337/dc15-0488
   CANO N, 1995, KIDNEY INT, V47, P1522, DOI 10.1038/ki.1995.215
   Cao J, 2014, J BIOL CHEM, V289, P20435, DOI 10.1074/jbc.M114.567271
   CHAN TM, 1976, ANAL BIOCHEM, V71, P96, DOI 10.1016/0003-2697(76)90014-2
   Collier GR, 1997, OBES RES, V5, P455, DOI 10.1002/j.1550-8528.1997.tb00670.x
   DALY M, 1975, J MAMMAL, V56, P509, DOI 10.2307/1379378
   DELPRATO S, 1995, DIABETES METAB REV, V11, pS33
   Duca FA, 2015, NAT MED, V21, P506, DOI 10.1038/nm.3787
   El-Mir MY, 2000, J BIOL CHEM, V275, P223, DOI 10.1074/jbc.275.1.223
   FELIG P, 1975, ANNU REV BIOCHEM, V44, P933, DOI 10.1146/annurev.bi.44.070175.004441
   Ferrannini E, 2014, METABOLISM, V63, P1217, DOI 10.1016/j.metabol.2014.05.012
   Finlayson A, 2015, WORLD J GASTRO ENDOS, V7, P1103, DOI [10.4253/wjge.v7.i13.1103, 10.4291/wjgp.v6.i4.110]
   Foretz M, 2014, CELL METAB, V20, P953, DOI 10.1016/j.cmet.2014.09.018
   FRENKEL G, 1972, LIFE SCI, V11, P209, DOI 10.1016/0024-3205(72)90006-9
   Fulgencio JP, 2001, BIOCHEM PHARMACOL, V62, P439, DOI 10.1016/S0006-2952(01)00679-7
   Fullerton MD, 2013, NAT MED, V19, P1649, DOI 10.1038/nm.3372
   Geerling JJ, 2014, DIABETES, V63, P880, DOI 10.2337/db13-0194
   Glueck CJ, 2001, METABOLISM, V50, P856, DOI 10.1053/meta.2001.24192
   Graham GG, 2011, CLIN PHARMACOKINET, V50, P81, DOI 10.2165/11534750-000000000-00000
   GROEN AK, 1982, EUR J BIOCHEM, V122, P87, DOI 10.1111/j.1432-1033.1982.tb05851.x
   Hamilton MK, 2015, AM J PHYSIOL-GASTR L, V308, pG840, DOI 10.1152/ajpgi.00029.2015
   Hansen AMK, 2011, DIABETOLOGIA, V54, P1379, DOI 10.1007/s00125-011-2080-1
   Harmel E, 2014, ENDOCRINOLOGY, V155, P873, DOI 10.1210/en.2013-1750
   He L, 2015, CELL METAB, V21, P159, DOI 10.1016/j.cmet.2015.01.003
   Ichai C, 2001, J BIOL CHEM, V276, P28126, DOI 10.1074/jbc.M010186200
   Inzucchi SE, 2012, DIABETOLOGIA, V55, P1577, DOI 10.1007/s00125-012-2534-0
   Kaiser Nurit, 2012, Methods Mol Biol, V933, P89, DOI 10.1007/978-1-62703-068-7_7
   Khalkhal A, 2010, CR BIOL, V335, P271
   KHAN NA, 1994, J ENDOCRINOL, V142, P245, DOI 10.1677/joe.0.1420245
   King H, 1998, DIABETES CARE, V21, P1414, DOI 10.2337/diacare.21.9.1414
   Koceir EA, 2003, DIABETES METAB, V29, P363, DOI 10.1016/S1262-3636(07)70047-2
   Kuznetsova TA, 2013, MICROB ECOL, V66, P940, DOI 10.1007/s00248-013-0263-7
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Ley RE, 2005, P NATL ACAD SCI USA, V102, P11070, DOI 10.1073/pnas.0504978102
   Lv WS, 2012, BRAIN RES, V1444, P11, DOI 10.1016/j.brainres.2012.01.028
   Madiraju AK, 2014, NATURE, V510, P542, DOI 10.1038/nature13270
   Mannucci E, 2001, DIABETES CARE, V24, P489, DOI 10.2337/diacare.24.3.489
   MARQUIE G, 1984, DIABETES, V33, P438, DOI 10.2337/diabetes.33.5.438
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Miller RA, 2010, J CLIN INVEST, V120, P2267, DOI 10.1172/JCI43661
   Nocito L, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0122818
   Owen MR, 2000, BIOCHEM J, V348, P607, DOI 10.1042/0264-6021:3480607
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Quadri I, 2016, MICROBIOL RES, V186, P119, DOI 10.1016/j.micres.2016.04.003
   Radziuk J, 1997, DIABETES, V46, P1406, DOI 10.2337/diabetes.46.9.1406
   Rapin JR, 2008, METFORMIN MECH INSIG, P131
   Sahraoui A, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0148117
   Salpeter SR, 2008, AM J MED, V121, P149, DOI 10.1016/j.amjmed.2007.09.016
   SCHAFER H, 1990, COMP BIOCHEM PHYS A, V95, P209, DOI 10.1016/0300-9629(90)90200-C
   Shafrir E, 2001, Int J Exp Diabetes Res, V2, P299, DOI 10.1155/EDR.2001.299
   Shafrir Eleazar, 1998, Journal of Basic and Clinical Physiology and Pharmacology, V9, P347
   SHIBKO S, 1967, ANAL BIOCHEM, V19, P514, DOI 10.1016/0003-2697(67)90242-4
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   SISTARE FD, 1985, J BIOL CHEM, V260, P2748
   Song YM, 2015, AUTOPHAGY, V11, P46, DOI 10.4161/15548627.2014.984271
   Spolding B, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0092656
   WILCOCK C, 1994, XENOBIOTICA, V24, P49, DOI 10.3109/00498259409043220
   Yasuda N, 2004, J PHARMACOL EXP THER, V310, P614, DOI 10.1124/jpet.103.064964
   Zhou GC, 2001, J CLIN INVEST, V108, P1167, DOI 10.1172/JCI200113505
NR 69
TC 13
Z9 13
U1 0
U2 6
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD FEB 21
PY 2017
VL 12
IS 2
AR e0172053
DI 10.1371/journal.pone.0172053
PG 17
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA EL5QV
UT WOS:000394676800029
PM 28222147
OA Green Published, Green Submitted, gold
DA 2023-06-08
ER

PT J
AU Wang, J
   Jia, HJ
AF Wang, Jun
   Jia, Huijue
TI Metagenome-wide association studies: fine-mining the microbiome
SO NATURE REVIEWS MICROBIOLOGY
LA English
DT Review
ID HUMAN GUT MICROBIOME; FUSOBACTERIUM-NUCLEATUM; INTESTINAL EPITHELIUM;
   FECAL MICROBIOTA; DISEASE; HEALTH; RESISTANCE; LANDSCAPE; METFORMIN;
   HUMANS
AB Metagenome-wide association studies (MWAS) have enabled the high-resolution investigation of associations between the human microbiome and several complex diseases, including type 2 diabetes, obesity, liver cirrhosis, colorectal cancer and rheumatoid arthritis. The associations that can be identified by MWAS are not limited to the identification of taxa that are more or less abundant, as is the case with taxonomic approaches, but additionally include the identification of microbial functions that are enriched or depleted. In this Review, we summarize recent findings from MWAS and discuss how these findings might inform the prevention, diagnosis and treatment of human disease in the future. Furthermore, we highlight the need to better characterize the biology of many of the bacteria that are found in the human microbiota as an essential step in understanding how bacterial strains that have been identified by MWAS are associated with disease.
C1 [Wang, Jun] ICarbonX, Shahe Ind Zone, 4018 Qiaoxiang Rd, Shenzhen 518083, Peoples R China.
   [Wang, Jun; Jia, Huijue] BGI Shenzhen, Shenzhen Key Lab Human Commensal Microorganisms &, Shenzhen 518083, Peoples R China.
C3 Beijing Genomics Institute (BGI)
RP Wang, J (通讯作者)，ICarbonX, Shahe Ind Zone, 4018 Qiaoxiang Rd, Shenzhen 518083, Peoples R China.; Wang, J (通讯作者)，BGI Shenzhen, Shenzhen Key Lab Human Commensal Microorganisms &, Shenzhen 518083, Peoples R China.
EM wangjun@icarbonx.com; jiahuijue@genomics.cn
RI Jia, Huijue/M-3991-2015; Xiao, Liang/L-5614-2016
OI Jia, Huijue/0000-0002-3592-126X; Xiao, Liang/0000-0003-0836-4397
FU Natural Science Foundation of China [30890032, 30725008, 30811130531];
   Shenzhen Municipal Government of China [JSGG20140702161403250,
   DRC-SZ[2015]162, CXB201108250098A]; Danish Strategic Research Council
   [2106-07-0021]; Danish Natural Science Research Council; Solexa project
   [272-07-0196]
FX This study was supported by the Natural Science Foundation of China
   (grants 30890032, 30725008 and 30811130531), the Shenzhen Municipal
   Government of China (grants JSGG20140702161403250, DRC-SZ[2015]162 and
   CXB201108250098A), the Danish Strategic Research Council (grant
   2106-07-0021) and the Ole ROmer grant from the Danish Natural Science
   Research Council and Solexa project (272-07-0196). The authors thank
   their colleagues at BGI, Shenzhen, China, especially J. Li, Z. Lan, S.
   Liang, H. Xie, D. Zhang, X. Luo, M. Arumugam and K. Kristiansen, for
   their help in the preparation of this Review. The authors also thank Y.
   Xie at Michigan State University, East Lansing, USA, for helpful
   discussions regarding this manuscript.
CR Aagaard K, 2014, SCI TRANSL MED, V6, DOI 10.1126/scitranslmed.3008599
   Albertsen M, 2013, NAT BIOTECHNOL, V31, P533, DOI 10.1038/nbt.2579
   Arumugam M, 2011, NATURE, V473, P174, DOI 10.1038/nature09944
   Atarashi K, 2013, NATURE, V500, P232, DOI 10.1038/nature12331
   Backhed F, 2007, P NATL ACAD SCI USA, V104, P979, DOI 10.1073/pnas.0605374104
   Backhed F, 2015, CELL HOST MICROBE, V17, P690, DOI [10.1016/j.chom.2015.04.004, 10.1016/j.chom.2015.05.012]
   Benson AK, 2015, GENOME BIOL, V16, DOI 10.1186/s13059-015-0775-1
   Benson AK, 2010, P NATL ACAD SCI USA, V107, P18933, DOI 10.1073/pnas.1007028107
   Braniste V, 2014, SCI TRANSL MED, V6, DOI 10.1126/scitranslmed.3009759
   Brenner H, 2014, LANCET, V383, P1490, DOI 10.1016/S0140-6736(13)61649-9
   Brubaker PL, 2003, CAN J PHYSIOL PHARM, V81, P1005, DOI 10.1139/Y03-107
   Cabreiro F, 2013, EMBO MOL MED, V5, P1300, DOI 10.1002/emmm.201100972
   Castellarin M, 2012, GENOME RES, V22, P299, DOI 10.1101/gr.126516.111
   Cho I, 2012, NAT REV GENET, V13, P260, DOI 10.1038/nrg3182
   Clemente JC, 2012, CELL, V148, P1258, DOI 10.1016/j.cell.2012.01.035
   Cotillard A, 2013, NATURE, V500, P585, DOI 10.1038/nature12480
   Cuskin F, 2015, NATURE, V517, P165, DOI 10.1038/nature13995
   Deane KD, 2014, NAT REV RHEUMATOL, V10, P212, DOI 10.1038/nrrheum.2014.6
   Demoruelle MK, 2014, CURR OPIN RHEUMATOL, V26, P64, DOI 10.1097/BOR.0000000000000017
   Ding T, 2014, NATURE, V509, P357, DOI 10.1038/nature13178
   Dobkin J F, 1982, Trans Assoc Am Physicians, V95, P22
   Dupont CL, 2012, ISME J, V6, P1186, DOI 10.1038/ismej.2011.189
   Erny D, 2015, NAT NEUROSCI, V18, P965, DOI 10.1038/nn.4030
   Feng Q, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms7528
   Ferlay J, 2015, INT J CANCER, V136, pE359, DOI 10.1002/ijc.29210
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Franzosa EA, 2015, NAT REV MICROBIOL, V13, P360, DOI 10.1038/nrmicro3451
   Freitas TAK, 2015, NUCLEIC ACIDS RES, V43, DOI 10.1093/nar/gkv180
   Fu JY, 2015, CIRC RES, V117, P817, DOI 10.1161/CIRCRESAHA.115.306807
   Gill S, 2015, CELL METAB, V22, P789, DOI 10.1016/j.cmet.2015.09.005
   Goodrich JK, 2014, CELL, V159, P789, DOI 10.1016/j.cell.2014.09.053
   Goto Y, 2014, SCIENCE, V345, P1310, DOI 10.1126/science.1254009
   Greenblum S, 2015, CELL, V160, P583, DOI 10.1016/j.cell.2014.12.038
   Gur C, 2015, IMMUNITY, V42, P344, DOI 10.1016/j.immuni.2015.01.010
   Haiser HJ, 2013, SCIENCE, V341, P295, DOI 10.1126/science.1235872
   Hildebrand F, 2012, BMC GENOMICS, V13, DOI 10.1186/1471-2164-13-514
   Hsiao EY, 2013, CELL, V155, P1451, DOI 10.1016/j.cell.2013.11.024
   Hu YF, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms3151
   Human Microbiome Project Consortium, 2012, Nature, V486, P207, DOI 10.1038/nature11234
   Iida N, 2013, SCIENCE, V342, P967, DOI 10.1126/science.1240527
   Jemal A, 2011, CA-CANCER J CLIN, V61, P134, DOI [10.3322/caac.20107, 10.3322/caac.20115]
   Joice R, 2014, CELL METAB, V20, P731, DOI 10.1016/j.cmet.2014.10.003
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Karlsson FH, 2012, NAT COMMUN, V3, DOI 10.1038/ncomms2266
   Kashyap PC, 2013, P NATL ACAD SCI USA, V110, P17059, DOI 10.1073/pnas.1306070110
   Kim KS, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms2789
   Koropatkin NM, 2012, NAT REV MICROBIOL, V10, P323, DOI 10.1038/nrmicro2746
   Kostic AD, 2013, CELL HOST MICROBE, V14, P207, DOI 10.1016/j.chom.2013.07.007
   Kostic AD, 2012, GENOME RES, V22, P292, DOI 10.1101/gr.126573.111
   Kovatcheva-Datchary P, 2015, CELL METAB, V22, P971, DOI 10.1016/j.cmet.2015.10.001
   Kuleshov V, 2016, NAT BIOTECHNOL, V34, P64, DOI 10.1038/nbt.3416
   Kultima JR, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0047656
   Lacombe A, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0067497
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Le Chatelier E, 2013, NATURE, V500, P541, DOI 10.1038/nature12506
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Lee SM, 2013, NATURE, V501, P426, DOI 10.1038/nature12447
   Ley RE, 2006, NATURE, V444, P1022, DOI 10.1038/4441022a
   Li J., 2014, ELECTRON J DIFFER EQ, V2014, P1, DOI DOI 10.1371/J0URNAL.P0NE.0089893
   Ling LL, 2015, NATURE, V517, P455, DOI 10.1038/nature14098
   Louis P, 2014, NAT REV MICROBIOL, V12, P661, DOI 10.1038/nrmicro3344
   Lukens JR, 2014, NATURE, V516, P246, DOI 10.1038/nature13788
   Lukovac S, 2014, MBIO, V5, DOI 10.1128/mBio.01438-14
   Marchesi JR, 2016, GUT, V65, P330, DOI 10.1136/gutjnl-2015-309990
   Marchesi JR, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0020447
   McLean Jeffrey S, 2013, Proc Natl Acad Sci U S A, V110, pE2390, DOI 10.1073/pnas.1219809110
   Mende DR, 2013, NAT METHODS, V10, P881, DOI [10.1038/NMETH.2575, 10.1038/nmeth.2575]
   Methe BA, 2012, NATURE, V486, P215, DOI 10.1038/nature11209
   Minot S, 2011, GENOME RES, V21, P1616, DOI 10.1101/gr.122705.111
   Modi SR, 2013, NATURE, V499, P219, DOI 10.1038/nature12212
   Motta JP, 2015, INFLAMM BOWEL DIS, V21, P1006, DOI 10.1097/MIB.0000000000000345
   Mukherji A, 2013, CELL, V153, P812, DOI 10.1016/j.cell.2013.04.020
   Nakatsu G, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms9727
   Nielsen HB, 2014, NAT BIOTECHNOL, V32, P822, DOI 10.1038/nbt.2939
   Norman JM, 2015, CELL, V160, P447, DOI 10.1016/j.cell.2015.01.002
   Oh J, 2014, NATURE, V514, P59, DOI 10.1038/nature13786
   Olle B, 2013, NAT BIOTECHNOL, V31, P309, DOI 10.1038/nbt.2548
   Olszak T, 2012, SCIENCE, V336, P489, DOI 10.1126/science.1219328
   Pickard JM, 2014, NATURE, V514, P638, DOI 10.1038/nature13823
   Pyra KA, 2012, J NUTR, V142, P213, DOI 10.3945/jn.111.147132
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Qin JJ, 2010, NATURE, V464, P59, DOI 10.1038/nature08821
   Qin N, 2014, NATURE, V513, P59, DOI 10.1038/nature13568
   Rausch P, 2011, P NATL ACAD SCI USA, V108, P19030, DOI 10.1073/pnas.1106408108
   Reyes A, 2010, NATURE, V466, P334, DOI 10.1038/nature09199
   Ridaura VK, 2013, SCIENCE, V341, P1079, DOI 10.1126/science.1241214
   Rinke C, 2013, NATURE, V499, P431, DOI 10.1038/nature12352
   Scher JU, 2013, ELIFE, V2, DOI 10.7554/eLife.01202
   Scher JU, 2012, ARTHRITIS RHEUM-US, V64, P3083, DOI 10.1002/art.34539
   Schloissnig S, 2013, NATURE, V493, P45, DOI 10.1038/nature11711
   Schwabe RF, 2013, NAT REV CANCER, V13, P800, DOI 10.1038/nrc3610
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Shoaie S, 2015, CELL METAB, V22, P320, DOI 10.1016/j.cmet.2015.07.001
   Sivan A, 2015, SCIENCE, V350, P1084, DOI 10.1126/science.aac4255
   Smillie CS, 2011, NATURE, V480, P241, DOI 10.1038/nature10571
   Sommer F, 2013, NAT REV MICROBIOL, V11, P227, DOI 10.1038/nrmicro2974
   Sonnenburg JL, 2005, SCIENCE, V307, P1955, DOI 10.1126/science.1109051
   Spanogiannopoulos P, 2016, NAT REV MICROBIOL, V14, P273, DOI 10.1038/nrmicro.2016.17
   Sridharan GV, 2014, NAT COMMUN, V5, DOI 10.1038/ncomms6492
   Stowell SR, 2014, NAT CHEM BIOL, V10, P470, DOI [10.1038/NCHEMBIO.1525, 10.1038/nchembio.1525]
   Sun J, 2015, IMMUNITY, V43, P304, DOI 10.1016/j.immuni.2015.07.013
   Sunagawa S, 2013, NAT METHODS, V10, P1196, DOI [10.1038/nmeth.2693, 10.1038/NMETH.2693]
   Tjalsma H, 2012, NAT REV MICROBIOL, V10, P575, DOI 10.1038/nrmicro2819
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Turnbaugh PJ, 2009, NATURE, V457, P480, DOI 10.1038/nature07540
   van Opstal EJ, 2015, SCIENCE, V349, P1172, DOI 10.1126/science.aab3958
   Vetizou M, 2015, SCIENCE, V350, P1079, DOI 10.1126/science.aad1329
   Viaud S, 2013, SCIENCE, V342, P971, DOI 10.1126/science.1240537
   Wang X, 2015, NATURE, V522, P173, DOI 10.1038/nature14484
   Wang ZN, 2015, CELL, V163, P1585, DOI 10.1016/j.cell.2015.11.055
   Weir TL, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0070803
   Weissmann G, 2006, BULL HOSP JT DIS, V64, P12
   Xiao L, 2015, NAT BIOTECHNOL, V33, P1103, DOI 10.1038/nbt.3353
   Xu J, 2015, ISME J, V9, P552, DOI 10.1038/ismej.2014.177
   Xu Y, 2013, JAMA-J AM MED ASSOC, V310, P948, DOI 10.1001/jama.2013.168118
   Yu J, 2017, GUT, V66, P70, DOI 10.1136/gutjnl-2015-309800
   Zeevi D, 2015, CELL, V163, P1079, DOI 10.1016/j.cell.2015.11.001
   Zeller G, 2014, MOL SYST BIOL, V10, DOI 10.15252/msb.20145645
   Zhang X, 2015, NAT MED, V21, P895, DOI 10.1038/nm.3914
   Zhou J, 2006, OBESITY, V14, P683, DOI 10.1038/oby.2006.77
NR 120
TC 236
Z9 253
U1 19
U2 290
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 1740-1526
EI 1740-1534
J9 NAT REV MICROBIOL
JI Nat. Rev. Microbiol.
PD AUG
PY 2016
VL 14
IS 8
BP 508
EP 522
DI 10.1038/nrmicro.2016.83
PG 15
WC Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology
GA DS1RV
UT WOS:000380376300009
PM 27396567
HC Y
HP N
DA 2023-06-08
ER

PT J
AU Stenman, LK
   Waget, A
   Garret, C
   Briand, F
   Burcelin, R
   Sulpice, T
   Lahtinen, S
AF Stenman, Lotta K.
   Waget, Aurelie
   Garret, Celine
   Briand, Francois
   Burcelin, Remy
   Sulpice, Thierry
   Lahtinen, Sampo
TI Probiotic B420 and prebiotic polydextrose improve efficacy of
   antidiabetic drugs in mice
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
DE Bifidobacteria; Diabetes; Gastroenterology; Obesity; Mice; Metformin;
   Probiotics; Prebiotics; Sitagliptin
ID HIGH-FAT-DIET; TYPE-2 DIABETES-MELLITUS; METABOLIC ENDOTOXEMIA; INDUCED
   OBESITY; GUT MICROBIOTA; INSULIN SENSITIVITY; GLUCOSE-INTOLERANCE; MOUSE
   MODEL; INFLAMMATION; MECHANISMS
AB Background: Gut microbiota is now known to control glucose metabolism. Previous studies have shown that probiotics and prebiotics may improve glucose metabolism, but their effects have not been studied in combination with drug therapy. The aim of this study was to investigate whether probiotics and prebiotics combined with drug therapy affect diabetic outcomes.
   Methods: Two different study designs were used to test gut microbiota modulating treatments with metformin (MET) or sitagliptin (SITA) in male C57Bl/6J mice. In Design 1, diabetes was induced with four-week feeding with a ketogenic, 72 kcal% fat diet with virtually no carbohydrates. Mice were then randomly divided into four groups (n = 10 in each group): (1) vehicle, (2) Bifidobacterium animalis ssp. lactis 420 (B420) (10(9) CFU/day), (3) MET (2 mg/mL in drinking water), or (4) MET + B420 (same doses as in the MET and B420 groups). After another 4 weeks, glucose metabolism was assessed with a glucose tolerance test. Fasting glucose, fasting insulin and HOMA-IR were also assessed. In Design 2, mice were fed the same 72 kcal% fat diet to induce diabetes, but they were simultaneously treated within their respective groups (n = 8 in each group): (1) non-diabetic healthy control, (2) vehicle, (3) SITA [ 3 mg/(kg*day)] (4) SITA with prebiotic polydextrose (PDX) (0.25 g/day), (5) SITA with B420 (109 CFU/day), and (6) SITA + PDX + B420. Glucose metabolism was assessed at 4 weeks, and weight development was monitored for 6 weeks.
   Results: In Design 1, with low-dose metformin, mice treated with B420 had a significantly lower glycemic response (area under the curve) (factorial experiment, P = 0.002) and plasma glucose concentration (P = 0.02) compared to mice not treated with B420. In Design 2, SITA + PDX reduced glycaemia in the oral glucose tolerance test significantly more than SITA only (area under the curve reduced 28 %, P < 0.0001). In addition, B420, PDX or B420+PDX, together with SITA, further decreased fasting glucose concentrations compared to SITA only (-19.5, -40 and -49 %, respectively, P < 0.01 for each comparison). The effect of PDX may be due to its ability to increase portal vein GLP-1 concentrations together with SITA (P = 0.0001 compared to vehicle) whereas SITA alone had no statistically significant effect compared to vehicle (P = 0.14).
   Conclusions: This study proposes that combining probiotics and/or prebiotics with antidiabetic drugs improves glycemic control and insulin sensitivity in mice. Mechanisms could be related to incretin secretion.
C1 [Stenman, Lotta K.; Lahtinen, Sampo] DuPont Nutr & Hlth, Act Nutr, Kantvik 02460, Finland.
   [Waget, Aurelie; Garret, Celine; Burcelin, Remy] Hop Rangueil, INSERM1048, Inst Malad Metab & Cardiovasc Rangueil, F-31432 Toulouse, France.
   [Briand, Francois; Sulpice, Thierry] Physiogenex SAS, Prologue Biotech, Labege, France.
C3 CHU de Toulouse; Universite de Toulouse; Universite Toulouse III - Paul
   Sabatier
RP Stenman, LK (通讯作者)，DuPont Nutr & Hlth, Act Nutr, Sokeritehtaantie 20, Kantvik 02460, Finland.
EM lotta.stenman@dupont.com
RI BRIAND, FRANCOIS/AAS-3030-2020; burcelin, remy/M-6013-2014
FU DuPont NH; Merck Sharp and Dohme Laboratories
FX DuPont N&H partly funded this study and provided the probiotic and
   prebiotic ingredients. This work was also partially supported by grants
   from the Merck Sharp and Dohme Laboratories to RB.
CR Amar J, 2011, EMBO MOL MED, V3, P559, DOI 10.1002/emmm.201100159
   Andreasen AS, 2010, BRIT J NUTR, V104, P1831, DOI 10.1017/S0007114510002874
   Burcelin M, 2002, AM J PHYSIOL-ENDOC M, V282, pE834, DOI 10.1152/ajpendo.00332.2001
   Burcelin R, 2014, GUT, V63, P706, DOI 10.1136/gutjnl-2013-305370
   Burcelin R, 2013, DIABETES OBES METAB, V15, P61, DOI 10.1111/dom.12157
   Burcelin R, 2012, SEMIN IMMUNOL, V24, P67, DOI 10.1016/j.smim.2011.11.011
   Cabreiro F, 2013, CELL, V153, P228, DOI 10.1016/j.cell.2013.02.035
   Cani PD, 2007, DIABETOLOGIA, V50, P2374, DOI 10.1007/s00125-007-0791-0
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Cotillard A, 2013, NATURE, V500, P585, DOI 10.1038/nature12480
   D'Aversa F, 2013, INTERN EMERG MED, V8, pS11, DOI 10.1007/s11739-013-0916-z
   Dehghan P, 2014, INT J FOOD SCI NUTR, V65, P117, DOI 10.3109/09637486.2013.836738
   DUNCAN L J, 1962, Br J Clin Pract, V16, P129
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Garidou L, 2015, CELL METAB, V22, P100, DOI 10.1016/j.cmet.2015.06.001
   Habbout A, 2013, J NUTR, V143, P553, DOI 10.3945/jn.112.172825
   Hartstra AV, 2015, DIABETES CARE, V38, P159, DOI 10.2337/dc14-0769
   Ibarra A, 2015, APPETITE, V87, P30, DOI 10.1016/j.appet.2014.12.099
   Kondo S, 2010, BIOSCI BIOTECH BIOCH, V74, P1656, DOI 10.1271/bbb.100267
   Lam YY, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0034233
   Le Chatelier E, 2013, NATURE, V500, P541, DOI 10.1038/nature12506
   Ley RE, 2006, NATURE, V444, P1022, DOI 10.1038/4441022a
   Lovshin JA, 2009, NAT REV ENDOCRINOL, V5, P262, DOI 10.1038/nrendo.2009.48
   Luche E, 2013, MOL METAB, V2, P281, DOI 10.1016/j.molmet.2013.06.005
   Neves AL, 2013, J MOL ENDOCRINOL, V51, pR51, DOI 10.1530/JME-13-0079
   Nielsen R, 2012, EXP CLIN ENDOCR DIAB, V120, P266, DOI 10.1055/s-0032-1304605
   Park DY, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0059470
   Pentinat T, 2010, ENDOCRINOLOGY, V151, P5617, DOI 10.1210/en.2010-0684
   Pernicova I, 2014, NAT REV ENDOCRINOL, V10, P143, DOI 10.1038/nrendo.2013.256
   Putaala H, 2008, RES MICROBIOL, V159, P692, DOI 10.1016/j.resmic.2008.08.002
   Russo F, 2010, CURR PHARM DESIGN, V16, P825, DOI 10.2174/138161210790883570
   Schwab U, 2006, EUR J CLIN NUTR, V60, P1073, DOI 10.1038/sj.ejcn.1602421
   Serino M, 2012, GUT, V61, P543, DOI 10.1136/gutjnl-2011-301012
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Stenman LK, 2014, BENEF MICROBES, V5, P437, DOI 10.3920/BM2014.0014
   Teixeira TFS, 2012, CLIN NUTR, V31, P735, DOI 10.1016/j.clnu.2012.02.009
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Vrieze A, 2012, GASTROENTEROLOGY, V143, P913, DOI 10.1053/j.gastro.2012.06.031
   Waget A, 2011, ENDOCRINOLOGY, V152, P3018, DOI 10.1210/en.2011-0286
   Walters WA, 2014, FEBS LETT, V588, P4223, DOI 10.1016/j.febslet.2014.09.039
   Zhong J, 2000, AM J CLIN NUTR, V72, P1503
NR 41
TC 37
Z9 39
U1 3
U2 34
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD SEP 12
PY 2015
VL 7
AR 75
DI 10.1186/s13098-015-0075-7
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CR0RO
UT WOS:000361031100001
PM 26366205
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Baxter, NT
   Lesniak, NA
   Sinani, H
   Schloss, PD
   Koropatkin, NM
AF Baxter, Nielsen T.
   Lesniak, Nicholas A.
   Sinani, Hamide
   Schloss, Patrick D.
   Koropatkin, Nicole M.
TI The Glucoamylase Inhibitor Acarbose Has a Diet-Dependent and Reversible
   Effect on the Murine Gut Microbiome
SO MSPHERE
LA English
DT Article
DE acarbose; gut microbiota; starch
ID CHAIN FATTY-ACIDS; RUMINOCOCCUS-BROMII; GLUCOSE-TOLERANCE; RESISTANT
   STARCH; SEQUENCE DATA; LARGE-BOWEL; BUTYRATE; FIBER; BIFIDOBACTERIA;
   DEGRADATION
AB Acarbose is a safe and effective medication for type 2 diabetes that inhibits host glucoamylases to prevent starch digestion in the small intestines and thus decrease postprandial blood glucose levels. This results in an increase in dietary starch in the distal intestine, where it becomes food for the gut bacterial community. Here, we examined the effect of acarbose therapy on the gut community structure in mice fed either a high-starch (HS) or high-fiber diet rich in plant polysaccharides (PP). The fecal microbiota of animals consuming a low dose of acarbose (25 ppm) was not significantly different from that of control animals that did not receive acarbose. However, a high dose of acarbose (400 ppm) with the HS diet resulted in a substantial change to the microbiota structure. Most notably, the HS diet with a high dose of acarbose lead to an expansion of the Bacteroidaceae and Bifidobacteriaceae and a decrease in the Verrucomicrobiaceae (such as Akkermansia muciniphila) and the Bacteroidales S24-7. Once acarbose treatment ceased, the community composition quickly reverted to mirror that of the control group, suggesting that acarbose does not irreversibly alter the gut community. The high dose of acarbose in the PP diet resulted in a distinct community structure with increased representation of Bifidobacteriaceae and Lachnospiraceae. Short-chain fatty acids (SCFAs) measured from stool samples were increased, especially butyrate, as a result of acarbose treatment in both diets. These data demonstrate the potential of acarbose to change the gut community structure and increase beneficial SCFA output in a diet-dependent manner.
   IMPORTANCE The gut microbial community has a profound influence on host physiology in both health and disease. In diabetic individuals, the gut microbiota can affect the course of disease, and some medications for diabetes, including metformin, seem to elicit some of their benefits via an interaction with the microbiota. Here, we report that acarbose, a glucoamylase inhibitor for type 2 diabetes, changes the murine gut bacterial community structure in a reversible and diet-dependent manner. In both high-starch and high-fiber diet backgrounds, acarbose treatment results in increased short-chain fatty acids, particularly butyrate, as measured in stool samples. As we learn more about how human disease is affected by the intestinal bacterial community, the interplay between medications such as acarbose and the diet will become increasingly important to evaluate.
C1 [Baxter, Nielsen T.; Lesniak, Nicholas A.; Sinani, Hamide; Schloss, Patrick D.; Koropatkin, Nicole M.] Univ Michigan, Sch Med, Dept Microbiol & Immunol, Ann Arbor, MI 48109 USA.
   [Baxter, Nielsen T.] Elanco Anim Hlth, Greenfield, IN USA.
C3 University of Michigan System; University of Michigan
RP Koropatkin, NM (通讯作者)，Univ Michigan, Sch Med, Dept Microbiol & Immunol, Ann Arbor, MI 48109 USA.
EM nkoropat@umich.edu
OI Schloss, Patrick/0000-0002-6935-4275
FU University of Michigan Gastrointestinal Peptides Research Center [DK
   034933]; Host Microbiome Initiative at the University of Michigan
   Medical School
FX This work was supported by funds from a pilot/feasibility grant from the
   University of Michigan Gastrointestinal Peptides Research Center (DK
   034933) awarded to N.M.K., as well as the Host Microbiome Initiative at
   the University of Michigan Medical School.
CR Abell GCJ, 2008, FEMS MICROBIOL ECOL, V66, P505, DOI 10.1111/j.1574-6941.2008.00527.x
   Barcenilla A, 2000, APPL ENVIRON MICROB, V66, P1654, DOI 10.1128/AEM.66.4.1654-1661.2000
   Birt DF, 2013, ADV NUTR, V4, P587, DOI 10.3945/an.113.004325
   Carmody RN, 2015, CELL HOST MICROBE, V17, P72, DOI 10.1016/j.chom.2014.11.010
   Casirola DM, 2006, METABOLISM, V55, P832, DOI 10.1016/j.metabol.2006.02.011
   Centanni M, 2018, APPL ENVIRON MICROB, V84, DOI 10.1128/AEM.00547-18
   Chiasson JL, 2003, JAMA-J AM MED ASSOC, V290, P486, DOI 10.1001/jama.290.4.486
   Cockburn DW, 2016, J MOL BIOL, V428, P3230, DOI 10.1016/j.jmb.2016.06.021
   David LA, 2014, NATURE, V505, P559, DOI 10.1038/nature12820
   Derrien M, 2004, INT J SYST EVOL MICR, V54, P1469, DOI 10.1099/ijs.0.02873-0
   Desai MS, 2016, CELL, V167, P1339, DOI 10.1016/j.cell.2016.10.043
   Dunne JL, 2014, CLIN EXP IMMUNOL, V177, P30, DOI 10.1111/cei.12321
   El Kaoutari A, 2013, NAT REV MICROBIOL, V11, P497, DOI 10.1038/nrmicro3050
   Mejia-Leon ME, 2014, SCI REP-UK, V4, DOI 10.1038/srep03814
   Flint HJ, 2012, GUT MICROBES, V3, P289, DOI 10.4161/gmic.19897
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Fukuda S, 2011, NATURE, V469, P543, DOI 10.1038/nature09646
   Garratt M, 2017, AGING CELL, V16, P1256, DOI 10.1111/acel.12656
   Gibbs VK, 2018, J GERONTOL A-BIOL, V73, P157, DOI 10.1093/gerona/glx127
   Hamer HM, 2008, ALIMENT PHARM THER, V27, P104, DOI 10.1111/j.1365-2036.2007.03562.x
   Hanefeld M, 2004, EUR HEART J, V25, P10, DOI 10.1016/S0195-668X(03)00468-8
   Hanefeld M, 2007, CARDIOVASC DIABETOL, V6, DOI 10.1186/1475-2840-6-20
   Harrison DE, 2014, AGING CELL, V13, P273, DOI 10.1111/acel.12170
   HILLEBRAND I, 1979, RES EXP MED, V175, P81, DOI 10.1007/BF01851236
   Holt PR, 1996, METABOLISM, V45, P1179, DOI 10.1016/S0026-0495(96)90020-7
   Ibrahim M, 2018, DIABETES-METAB RES, V34, DOI 10.1002/dmrr.3021
   Kimura I, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms2852
   Koh A, 2016, CELL, V165, P1332, DOI 10.1016/j.cell.2016.05.041
   Koropatkin NM, 2012, NAT REV MICROBIOL, V10, P323, DOI 10.1038/nrmicro2746
   Kozich JJ, 2013, APPL ENVIRON MICROB, V79, P5112, DOI 10.1128/AEM.01043-13
   Lagkouvardos I, 2016, NAT MICROBIOL, V1, DOI [10.1038/nmicrobiol.2016.131, 10.1038/NMICROBIOL.2016.131]
   Lin HV, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0035240
   Louis P, 2017, ENVIRON MICROBIOL, V19, P29, DOI 10.1111/1462-2920.13589
   Martinez I, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0015046
   Mathewson ND, 2016, NAT IMMUNOL, V17, P505, DOI 10.1038/ni.3400
   MCINTYRE A, 1993, GUT, V34, P386, DOI 10.1136/gut.34.3.386
   McIver L.A., 2018, ACARBOSE
   McOrist AL, 2011, J NUTR, V141, P883, DOI 10.3945/jn.110.128504
   Morrison DJ, 2016, GUT MICROBES, V7, P189, DOI 10.1080/19490976.2015.1134082
   Okada K, 2009, HEPATOL RES, V39, P490, DOI 10.1111/j.1872-034X.2008.00478.x
   Ormerod KL, 2016, MICROBIOME, V4, DOI 10.1186/s40168-016-0181-2
   Pereira FC, 2017, ENVIRON MICROBIOL, V19, P1366, DOI 10.1111/1462-2920.13659
   Petlevski Roberta, 2006, Acta Pharmaceutica (Zagreb), V56, P87
   Pruesse E, 2007, NUCLEIC ACIDS RES, V35, P7188, DOI 10.1093/nar/gkm864
   Pryde SE, 2002, FEMS MICROBIOL LETT, V217, P133, DOI 10.1111/j.1574-6968.2002.tb11467.x
   Reagan-Shaw S, 2008, FASEB J, V22, P659, DOI 10.1096/fj.07-9574LSF
   Santilli AD, 2018, ACS CHEM BIOL, V13, P1165, DOI 10.1021/acschembio.8b00309
   Schloss PD, 2009, APPL ENVIRON MICROB, V75, P7537, DOI 10.1128/AEM.01541-09
   Seedorf H, 2014, CELL, V159, P253, DOI 10.1016/j.cell.2014.09.008
   Segain JP, 2000, GUT, V47, P397, DOI 10.1136/gut.47.3.397
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Sonnenburg ED, 2016, NATURE, V529, P212, DOI 10.1038/nature16504
   Su BL, 2015, J DIABETES, V7, P729, DOI 10.1111/1753-0407.12232
   Takagi T, 2018, J CLIN BIOCHEM NUTR, V62, P100, DOI 10.3164/jcbn.17-78
   Tremaroli V, 2012, NATURE, V489, P242, DOI 10.1038/nature11552
   Tsuda A, 2015, CLIN TRANSL GASTROEN, V6, DOI 10.1038/ctg.2015.20
   Venkataraman A, 2016, MICROBIOME, V4, DOI 10.1186/s40168-016-0178-x
   Walker AW, 2011, ISME J, V5, P220, DOI 10.1038/ISMEJ.2010.118
   Wang X, 1999, APPL ENVIRON MICROB, V65, P4848
   Weaver GA, 1997, J NUTR, V127, P717, DOI 10.1093/jn/127.5.717
   Westcott SL, 2017, MSPHERE, V2, DOI 10.1128/mSphereDirect.00073-17
   Wolever TMS, 2000, BRIT J NUTR, V84, P57
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Yan WW, 2015, BRAIN RES, V1603, P22, DOI 10.1016/j.brainres.2015.01.042
   Yu MH, 2018, VASC PHARMACOL, V103, P8, DOI 10.1016/j.vph.2018.02.001
   Ze XL, 2012, ISME J, V6, P1535, DOI 10.1038/ismej.2012.4
   Zhang XY, 2017, DIABETES THER, V8, P293, DOI 10.1007/s13300-017-0226-y
NR 67
TC 38
Z9 39
U1 6
U2 13
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 2379-5042
J9 MSPHERE
JI mSphere
PD JAN-FEB
PY 2019
VL 4
IS 1
AR e00528-18
DI 10.1128/mSphere.00528-18
PG 12
WC Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology
GA HN8KU
UT WOS:000460444700019
PM 30728281
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Hasain, Z
   Mokhtar, NM
   Kamaruddin, NA
   Ismail, NAM
   Razalli, NH
   Gnanou, JV
   Ali, RAR
AF Hasain, Zubaidah
   Mokhtar, Norfilza Mohd
   Kamaruddin, Nor Azmi
   Ismail, Nor Azlin Mohamed
   Razalli, Nurul Huda
   Gnanou, Justin Vijay
   Ali, Raja Affendi Raja
TI Gut Microbiota and Gestational Diabetes Mellitus: A Review of Host-Gut
   Microbiota Interactions and Their Therapeutic Potential
SO FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
LA English
DT Review
DE gut microbiota; gestational diabetes; probiotics; host microbial
   interactions; short-chain fatty acids
ID CHAIN FATTY-ACIDS; DIET-INDUCED OBESITY; INSULIN SENSITIVITY;
   INFLAMMATORY CYTOKINES; INTESTINAL MICROBIOTA; DOUBLE-BLIND;
   BODY-WEIGHT; FOLLOW-UP; PROBIOTICS; PREGNANCY
AB Gestational diabetes mellitus (GDM) is defined as impaired glucose tolerance recognized during pregnancy. GDM is associated with metabolic disorder phenotypes, such as obesity, low-grade inflammation, and insulin resistance. Following delivery, nearly half of the women with a history of GDM have persistent postpartum glucose intolerance and an increased risk of developing type 2 diabetes mellitus (T2DM), as much as 7-fold. The alarming upward trend may worsen the socioeconomic burden worldwide. Accumulating evidence strongly associates gut microbiota dysbiosis in women with GDM, similar to the T2DM profile. Several metagenomics studies have shown gut microbiota, such as Ruminococcaceae,Parabacteroides distasonis, andPrevotella, were enriched in women with GDM. These microbiota populations are associated with metabolic pathways for carbohydrate metabolism and insulin signaling, suggesting a potential "gut microbiota signature" in women with GDM. Furthermore, elevated expression of serum zonulin, a marker of gut epithelial permeability, during early pregnancy in women with GDM indicates a possible link between gut microbiota and GDM. Nevertheless, few studies have revealed discrepant results, and the interplay between gut microbiota dysbiosis and host metabolism in women with GDM is yet to be elucidated. Lifestyle modification and pharmacological treatment with metformin showed evidence of modulation of gut microbiota and proved to be beneficial to maintain glucose homeostasis in T2DM. Nonetheless, post-GDM women have poor compliance toward lifestyle modification after delivery, and metformin treatment remains controversial as a T2DM preventive strategy. We hypothesized modulation of the composition of gut microbiota with probiotics supplementation may reverse postpartum glucose intolerance in post-GDM women. In this review, we addressed gut microbiota dysbiosis and the possible mechanistic links between the host and gut microbiota in women with GDM. Furthermore, this review highlights the potential therapeutic use of probiotics in post-GDM women as a T2DM preventive strategy.
C1 [Hasain, Zubaidah; Mokhtar, Norfilza Mohd] Univ Kebangsaan Malaysia, Fac Med, Dept Physiol, Cheras, Malaysia.
   [Hasain, Zubaidah] Natl Def Univ Malaysia, Fac Med, Kuala Lumpur, Malaysia.
   [Mokhtar, Norfilza Mohd; Razalli, Nurul Huda; Ali, Raja Affendi Raja] Univ Kebangsaan Malaysia, Fac Med, GUT Res Grp, Kuala Lumpur, Malaysia.
   [Kamaruddin, Nor Azmi] Univ Kebangsaan Malaysia, Fac Med, Dept Med, Endocrine Unit, Cheras, Malaysia.
   [Ismail, Nor Azlin Mohamed] Univ Kebangsaan Malaysia, Fac Med, Dept Obstet & Gynecol, Kuala Lumpur, Malaysia.
   [Razalli, Nurul Huda] Univ Kebangsaan Malaysia, Fac Hlth Sci, Dietet Program, Kuala Lumpur, Malaysia.
   [Gnanou, Justin Vijay] Int Med Univ, Sch Med, Bukit Jalil, Malaysia.
   [Ali, Raja Affendi Raja] Univ Kebangsaan Malaysia, Fac Med, Dept Med, Gastroenterol Unit, Cheras, Malaysia.
C3 Universiti Kebangsaan Malaysia; Universiti Pertahanan Nasional Malaysia;
   Universiti Kebangsaan Malaysia; Universiti Kebangsaan Malaysia;
   Universiti Kebangsaan Malaysia; Universiti Kebangsaan Malaysia;
   International Medical University Malaysia; Universiti Kebangsaan
   Malaysia
RP Mokhtar, NM (通讯作者)，Univ Kebangsaan Malaysia, Fac Med, Dept Physiol, Cheras, Malaysia.; Mokhtar, NM; Ali, RAR (通讯作者)，Univ Kebangsaan Malaysia, Fac Med, GUT Res Grp, Kuala Lumpur, Malaysia.; Ali, RAR (通讯作者)，Univ Kebangsaan Malaysia, Fac Med, Dept Med, Gastroenterol Unit, Cheras, Malaysia.
EM norfilza@ppukm.ukm.edu.my; draffendi@ppukm.ukm.edu.my
RI Mokhtar, Norfilza Mohd/AAK-8196-2020; Hasain, Zubaidah/HHD-1313-2022
OI Mokhtar, Norfilza Mohd/0000-0002-4863-100X; 
FU Universiti Kebangsaan Malaysia Research University Fund [AP-2017-008/2];
   B-Crobes Marketing (M) Sdn Bhd.
FX This study was supported by the Universiti KebangsaanMalaysia Research
   University Fund (AP-2017-008/2) in collaboration with B-Crobes Marketing
   (M) Sdn Bhd. The open access publication fees is paid by the Faculty of
   Medicine, Universiti Kebangsaan Malaysia.
CR Aberdein N, 2014, ADIPOCYTE, V3, P121, DOI 10.4161/adip.27936
   Akira S, 2004, NAT REV IMMUNOL, V4, P499, DOI 10.1038/nri1391
   Ali RAR, 2018, GASTROENTEROLOGY, V154, pS414
   Allalou A, 2016, DIABETES, V65, P2529, DOI 10.2337/db15-1720
   Amar J, 2011, EMBO MOL MED, V3, P559, DOI 10.1002/emmm.201100159
   Ananthakrishnan AN, 2018, NAT REV GASTRO HEPAT, V15, P39, DOI 10.1038/nrgastro.2017.136
   Avershina E, 2014, FEMS MICROBIOL ECOL, V87, P280, DOI 10.1111/1574-6941.12223
   Backhed F, 2005, SCIENCE, V307, P1915, DOI 10.1126/science.1104816
   Bagarolli RA, 2017, J NUTR BIOCHEM, V50, P16, DOI 10.1016/j.jnutbio.2017.08.006
   Bawah AT, 2019, INT J DIABETES DEV C, V39, P451, DOI 10.1007/s13410-019-00715-4
   Beauvieux Marie-Christine, 2008, BMC Physiology, V8, P19, DOI 10.1186/1472-6793-8-19
   Bellamy L, 2009, LANCET, V373, P1773, DOI 10.1016/S0140-6736(09)60731-5
   Beucher G, 2010, DIABETES METAB, V36, P522, DOI 10.1016/j.diabet.2010.11.006
   Blaut M, 2015, P NUTR SOC, V74, P227, DOI 10.1017/S0029665114001700
   Bloemen JG, 2009, CLIN NUTR, V28, P657, DOI 10.1016/j.clnu.2009.05.011
   Buchanan TA, 2012, NAT REV ENDOCRINOL, V8, P639, DOI 10.1038/nrendo.2012.96
   Canfora EE, 2015, NAT REV ENDOCRINOL, V11, P577, DOI 10.1038/nrendo.2015.128
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   Cani PD, 2012, GUT MICROBES, V3, P279, DOI 10.4161/gmic.19625
   Caricilli AM, 2013, NUTRIENTS, V5, P829, DOI 10.3390/nu5030829
   Catalano PM, 2012, DIABETES CARE, V35, P780, DOI 10.2337/dc11-1790
   Cheung NW, 2006, J DIABETES COMPLICAT, V20, P21, DOI 10.1016/j.jdiacomp.2005.05.001
   CLAUSEN MR, 1995, GUT, V37, P684, DOI 10.1136/gut.37.5.684
   Collado MC, 2007, LETT APPL MICROBIOL, V45, P454, DOI 10.1111/j.1472-765X.2007.02212.x
   Cortez RV, 2019, ENDOCRINE, V64, P254, DOI 10.1007/s12020-018-1813-z
   Crusell MKW, 2018, MICROBIOME, V6, DOI 10.1186/s40168-018-0472-x
   DEMIGNE C, 1995, BRIT J NUTR, V74, P209, DOI 10.1079/BJN19950124
   Demir E, 2019, BIOMOLECULES, V9, DOI 10.3390/biom9010024
   den Besten G, 2015, DIABETES, V64, P2398, DOI 10.2337/db14-1213
   den Besten G, 2013, AM J PHYSIOL-GASTR L, V305, pG900, DOI 10.1152/ajpgi.00265.2013
   Didari T, 2014, EXPERT OPIN DRUG SAF, V13, P227, DOI 10.1517/14740338.2014.872627
   DiGiulio DB, 2015, P NATL ACAD SCI USA, V112, P11060, DOI 10.1073/pnas.1502875112
   Dolatkhah N, 2015, J HEALTH POPUL NUTR, V33, DOI 10.1186/s41043-015-0034-9
   Eades CE, 2015, BMC PREGNANCY CHILDB, V15, DOI 10.1186/s12884-015-0457-8
   Eamin EE, 2013, J NUTR, V143, P1872, DOI 10.3945/jn.113.179549
   Ehrlich SF, 2011, OBSTET GYNECOL, V117, P1323, DOI 10.1097/AOG.0b013e31821aa358
   Everard A, 2013, BEST PRACT RES CL GA, V27, P73, DOI 10.1016/j.bpg.2013.03.007
   Fernandes J, 2014, NUTR DIABETES, V4, DOI 10.1038/nutd.2014.23
   Ferrocino I, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-30735-9
   Festa C, 2018, DIABETES, V67, DOI 10.2337/db18-2345-PUB
   Flint HJ, 2008, NAT REV MICROBIOL, V6, P121, DOI 10.1038/nrmicro1817
   Flint HJ, 2012, GUT MICROBES, V3, P289, DOI 10.4161/gmic.19897
   Franzosa EA, 2014, P NATL ACAD SCI USA, V111, pE2329, DOI 10.1073/pnas.1319284111
   Fugmann M, 2015, SCI REP-UK, V5, DOI 10.1038/srep13212
   Furusawa Y, 2013, NATURE, V504, P446, DOI 10.1038/nature12721
   Fushimi T, 2001, J NUTR, V131, P1973, DOI 10.1093/jn/131.7.1973
   Gao ZG, 2009, DIABETES, V58, P1509, DOI 10.2337/db08-1637
   Ge HF, 2008, ENDOCRINOLOGY, V149, P4519, DOI 10.1210/en.2008-0059
   Girgis Christian M, 2012, ISRN Endocrinol, V2012, P341638, DOI 10.5402/2012/341638
   Gomes AC, 2014, NUTR J, V13, DOI 10.1186/1475-2891-13-60
   Gomez-Arango LF, 2016, DIABETES, V65, P2214, DOI 10.2337/db16-0278
   Grenham S, 2011, FRONT PHYSIOL, V2, DOI 10.3389/fphys.2011.00094
   Grootaert C, 2011, ENVIRON MICROBIOL, V13, P1778, DOI 10.1111/j.1462-2920.2011.02482.x
   Hamilton MK, 2015, AM J PHYSIOL-GASTR L, V308, pG840, DOI 10.1152/ajpgi.00029.2015
   Han JL, 2014, WORLD J GASTROENTERO, V20, P17737, DOI 10.3748/wjg.v20.i47.17737
   Hasain Z, 2019, GUT, V68, pA96, DOI 10.1136/gutjnl-2019-IDDFabstracts.180
   Hasan S, 2018, ACTA OBSTET GYN SCAN, V97, P38, DOI 10.1111/aogs.13252
   Hill C, 2014, NAT REV GASTRO HEPAT, V11, P506, DOI 10.1038/nrgastro.2014.66
   Hong YH, 2005, ENDOCRINOLOGY, V146, P5092, DOI 10.1210/en.2005-0545
   Hornef M, 2015, ILAR J, V56, P159, DOI 10.1093/ilar/ilv007
   Hosseinzadeh P, 2013, INT J PREVENTIVE MED, V4, P1131
   Huttenhower C, 2012, NATURE, V486, P207, DOI 10.1038/nature11234
   Ibrahim NS, 2018, J SPORT MED PHYS FIT, V58, P1102, DOI 10.23736/S0022-4707.17.07742-8
   Ismail Nor Azlin Mohamed, 2011, Acta Medica (Hradec Kralove), V54, P21
   Jafarnejad S, 2016, J NUTR METAB, V2016, DOI 10.1155/2016/5190846
   Saez-Lara MJ, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17060928
   Saez-Lara MJ, 2015, BIOMED RES INT-UK, V2015, DOI 10.1155/2015/505878
   Jovel J, 2016, FRONT MICROBIOL, V7, DOI 10.3389/fmicb.2016.00459
   Kaiser B, 2013, J NURS MANAGE, V21, P58, DOI 10.1111/jonm.12006
   Kamana KC, 2015, ANN NUTR METAB, V66, P14, DOI 10.1159/000371628
   Karamali M, 2016, DIABETES METAB, V42, P234, DOI 10.1016/j.diabet.2016.04.009
   Kim C, 2014, DIABETIC MED, V31, P292, DOI 10.1111/dme.12382
   Kim C, 2002, DIABETES CARE, V25, P1862, DOI 10.2337/diacare.25.10.1862
   Kim C, 2014, MATERN CHILD HLTH J, V18, P698, DOI 10.1007/s10995-013-1295-9
   Kim F, 2007, CIRC RES, V100, P1589, DOI 10.1161/CIRCRESAHA.106.142851
   Koren O, 2012, CELL, V150, P470, DOI 10.1016/j.cell.2012.07.008
   Kuang YS, 2017, GIGASCIENCE, V6, DOI 10.1093/gigascience/gix058
   Kulski J., 2016, NEXT GENERATION SEQU, DOI DOI 10.5772/61964
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Le Barz M, 2019, FASEB J, V33, P4921, DOI 10.1096/fj.201801672R
   Le Chatelier E, 2013, NATURE, V500, P541, DOI 10.1038/nature12506
   Lee YY, 2017, J PAEDIATR CHILD H, V53, P1152, DOI 10.1111/jpc.13640
   Li CF, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000004088
   Lindsay KL, 2015, AM J OBSTET GYNECOL, V212, DOI 10.1016/j.ajog.2015.02.008
   Liu H, 2019, FRONT PHYSIOL, V10, DOI 10.3389/fphys.2019.01015
   Lloyd-Price J, 2016, GENOME MED, V8, DOI 10.1186/s13073-016-0307-y
   Ma X, 2008, J HEPATOL, V49, P821, DOI 10.1016/j.jhep.2008.05.025
   Macfarlane S, 2003, P NUTR SOC, V62, P67, DOI 10.1079/PNS2002207
   Miquel S, 2014, GUT MICROBES, V5, P146, DOI 10.4161/gmic.27651
   Mokkala K, 2017, NUTR DIABETES, V7, DOI 10.1038/nutd.2017.9
   Mokkala K, 2017, ACTA DIABETOL, V54, P1147, DOI 10.1007/s00592-017-1056-0
   Mor G, 2010, AM J REPROD IMMUNOL, V63, P425, DOI 10.1111/j.1600-0897.2010.00836.x
   Muccioli GG, 2010, MOL SYST BIOL, V6, DOI 10.1038/msb.2010.46
   Nishimura Satoshi, 2010, Journal of Biorheology, V24, P11, DOI 10.1007/s12573-010-0020-1
   Nishimura S, 2009, NAT MED, V15, P914, DOI 10.1038/nm.1964
   O'Sullivan O, 2015, GUT MICROBES, V6, P131, DOI 10.1080/19490976.2015.1011875
   Ohira H, 2013, J ATHEROSCLER THROMB, V20, P425, DOI 10.5551/jat.15065
   Plows JF, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19113342
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Qin JJ, 2010, NATURE, V464, P59, DOI 10.1038/nature08821
   Ranjan R, 2016, BIOCHEM BIOPH RES CO, V469, P967, DOI 10.1016/j.bbrc.2015.12.083
   Rodes L, 2013, J MICROBIOL BIOTECHN, V23, P518, DOI 10.4014/jmb.1205.05018
   Roelofsen H, 2010, BENEF MICROBES, V1, P433, DOI 10.3920/BM2010.0028
   Sacks DA, 2012, DIABETES CARE, V35, P526, DOI 10.2337/dc11-1641
   Salguero MV, 2019, EXP THER MED, V18, P3461, DOI 10.3892/etm.2019.7943
   Santacruz A, 2010, BRIT J NUTR, V104, P83, DOI 10.1017/S0007114510000176
   Schwiertz A, 2010, OBESITY, V18, P190, DOI 10.1038/oby.2009.167
   Sotoudegan F, 2019, FOOD CHEM TOXICOL, V129, P22, DOI 10.1016/j.fct.2019.04.032
   Stein SA, 2013, EXPERT OPIN DRUG SAF, V12, P153, DOI 10.1517/14740338.2013.752813
   Taddei CR, 2018, AM J REPROD IMMUNOL, V80, DOI 10.1111/aji.12993
   Taylor BL, 2017, NUTRIENTS, V9, DOI 10.3390/nu9050461
   Tazoe H, 2008, J PHYSIOL PHARMACOL, V59, P251
   Tilg H, 2014, GUT, V63, P1513, DOI 10.1136/gutjnl-2014-306928
   Topping DL, 2001, PHYSIOL REV, V81, P1031, DOI 10.1152/physrev.2001.81.3.1031
   Tremaroli V, 2012, NATURE, V489, P242, DOI 10.1038/nature11552
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Vijay-Kumar M, 2010, SCIENCE, V328, P228, DOI 10.1126/science.1179721
   Vrieze A, 2012, GASTROENTEROLOGY, V143, P913, DOI 10.1053/j.gastro.2012.06.031
   Wang JF, 2018, GUT, V67, P1614, DOI 10.1136/gutjnl-2018-315988
   WOLEVER TMS, 1991, AM J CLIN NUTR, V53, P681, DOI 10.1093/ajcn/53.3.681
   Wright DP, 2000, FEMS MICROBIOL LETT, V190, P73, DOI 10.1016/S0378-1097(00)00324-4
   Wu GD, 2011, SCIENCE, V334, P105, DOI 10.1126/science.1208344
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Yadav H, 2013, J BIOL CHEM, V288, P25088, DOI 10.1074/jbc.M113.452516
   Ye GY, 2019, J DIABETES RES, V2019, DOI 10.1155/2019/6081248
   Zaharuddin L, 2019, BMC GASTROENTEROL, V19, DOI 10.1186/s12876-019-1047-4
   Zhou J, 2015, MOL NUTR FOOD RES, V59, P1000, DOI 10.1002/mnfr.201400904
NR 128
TC 66
Z9 71
U1 8
U2 30
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2235-2988
J9 FRONT CELL INFECT MI
JI Front. Cell. Infect. Microbiol.
PD MAY 15
PY 2020
VL 10
AR 188
DI 10.3389/fcimb.2020.00188
PG 19
WC Immunology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Microbiology
GA MV9YH
UT WOS:000556703900001
PM 32500037
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Wang, JY
   Chen, PW
   Cao, QY
   Wang, W
   Chang, X
AF Wang, Junyan
   Chen, Peiwen
   Cao, Qiuyu
   Wang, Wei
   Chang, Xing
TI Traditional Chinese Medicine Ginseng Dingzhi Decoction Ameliorates
   Myocardial Fibrosis and High Glucose-Induced Cardiomyocyte Injury by
   Regulating Intestinal Flora and Mitochondrial Dysfunction
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID HEART-FAILURE; REPERFUSION INJURY; PRESSURE-OVERLOAD; BAX INHIBITOR-1;
   QUALITY-CONTROL; INFLAMMASOME; MITOPHAGY; HOMEOSTASIS; DYNAMICS
AB Myocardial fibrosis refers to the pathological changes of heart structure and morphology caused by various reasons of myocardial damage. It has become an important challenge in the later clinical treatment of acute myocardial infarction/ischemic cardiomyopathy or diabetes complicated with heart failure. Ginseng Dingzhi Decoction (GN), a Chinese herbal medicine, can reduce heart failure and protect cardiomyocytes. We infer that this may be related to the interaction with intestinal microbiota and mitochondrial homeostasis. The regulatory mechanism of GN on gut microbiota and mitochondria has not yet been elucidated. The intestinal microbiota was analyzed by the 16S rRNA gene; the fecal samples were sequenced and statistically analyzed to determine the changes of microbiota in the phenotype of heart failure rats. In addition, GN can regulate the microbial population that increases the proportion of short-chain fatty acids and anti-inflammatory bacteria and reduces the proportion of conditional pathogens to diabetic phenotype. The results suggest that GN may improve myocardial injury by regulating intestinal flora. Our data also show that stress-type heart failure caused by TAC (transverse aortic constriction) is accompanied by severe cardiac hypertrophy, reduced cardiac function, redox imbalance, and mitochondrial dysfunction. However, the use of GN intervention can significantly reduce heart failure and myocardial hypertrophy, improve heart function and improve myocardial damage, and maintain the mitochondrial homeostasis and redox of myocardial cells under high glucose stimulation. Interestingly, through in vitro experiments after TMBIM6 siRNA treatment, the improvement effect of GN on cell damage and the regulation of mitochondrial homeostasis were eliminated. TMBIM6 can indirectly regulate mitophagy and mitochondrial homeostasis to attenuate myocardial damage and confirms the regulatory effect of GN on mitophagy and mitochondrial homeostasis. We further intervened cardiomyocytes in high glucose through metformin (MET) and GN combination therapy. Research data show that MET and GN combination therapy can improve the level of mitophagy and protect cardiomyocytes. Our findings provide novel mechanistic insights for the treatment of diabetes combined with myocardial injury (myocardial fibrosis) and provide a pharmacological basis for the study of the combination of Chinese medicine and conventional diabetes treatment drugs.
C1 [Wang, Junyan; Cao, Qiuyu; Wang, Wei] Guangzhou Univ Chinese Med, Sch Pharmaceut Sci, Guangzhou 510006, Peoples R China.
   [Chen, Peiwen] Guangzhou Univ Chinese Med, Clin Med Sch 1, Guangzhou 510405, Peoples R China.
   [Chang, Xing] Chinese Acad Tradit Chinese Med, Guanganmen Hosp, Beijing 100053, Peoples R China.
C3 Guangzhou University of Chinese Medicine; Guangzhou University of
   Chinese Medicine; China Academy of Chinese Medical Sciences; Guang'anmen
   Hospital, CACMS
RP Wang, W (通讯作者)，Guangzhou Univ Chinese Med, Sch Pharmaceut Sci, Guangzhou 510006, Peoples R China.; Chang, X (通讯作者)，Chinese Acad Tradit Chinese Med, Guanganmen Hosp, Beijing 100053, Peoples R China.
EM wangwei26960@126.com; xingchang_tcm@outlook.com
RI Chang, Xing/AAQ-3281-2021
OI Chang, Xing/0000-0002-3788-9881; wang, jun yan/0000-0002-2048-2225
FU China Postdoctoral Science Foundation [2021M700966]
FX This study was supported by the China Postdoctoral Science Foundation
   (2021M700966).
CR Abbate A, 2020, CIRC RES, V126, P1260, DOI 10.1161/CIRCRESAHA.120.315937
   Aldosari S, 2018, ANTIOXIDANTS-BASEL, V7, DOI 10.3390/antiox7010014
   [Anonymous], 2001, ADV GERONTOL, V6, P6
   Ashrafi G, 2013, CELL DEATH DIFFER, V20, P31, DOI 10.1038/cdd.2012.81
   Bacmeister L, 2019, BASIC RES CARDIOL, V114, DOI 10.1007/s00395-019-0722-5
   Borlaug BA, 2020, NAT REV CARDIOL, V17, P559, DOI 10.1038/s41569-020-0363-2
   Bravo-San Pedro JM, 2017, CIRC RES, V120, P1812, DOI 10.1161/CIRCRESAHA.117.311082
   Cadenas S, 2018, BBA-BIOENERGETICS, V1859, P940, DOI 10.1016/j.bbabio.2018.05.019
   Cameron AR, 2016, CIRC RES, V119, P652, DOI 10.1161/CIRCRESAHA.116.308445
   Chan DC, 2020, ANNU REV PATHOL-MECH, V15, P235, DOI 10.1146/annurev-pathmechdis-012419-032711
   Chang X, 2021, OXID MED CELL LONGEV, V2021, DOI 10.1155/2021/3154501
   Chang X, 2021, OXID MED CELL LONGEV, V2021, DOI 10.1155/2021/5529913
   Chen CY, 2020, EUR J CLIN INVEST, V50, DOI 10.1111/eci.13204
   Chen M, 2016, AUTOPHAGY, V12, P689, DOI 10.1080/15548627.2016.1151580
   Chouchani ET, 2014, NATURE, V515, P431, DOI 10.1038/nature13909
   Crespo-Leiro MG, 2018, EUR J HEART FAIL, V20, P1505, DOI 10.1002/ejhf.1236
   Dia M, 2020, BASIC RES CARDIOL, V115, DOI 10.1007/s00395-020-00835-7
   Dillmann WH, 2019, CIRC RES, V124, P1160, DOI 10.1161/CIRCRESAHA.118.314665
   Gonzalez A, 2018, J AM COLL CARDIOL, V71, P1696, DOI 10.1016/j.jacc.2018.02.021
   Ibanez B, 2019, JACC-CARDIOVASC IMAG, V12, P2457, DOI 10.1016/j.jcmg.2019.04.004
   Karamitsos TD, 2020, JACC-CARDIOVASC IMAG, V13, P1221, DOI [10.1016/j.cmg.2019.06.030, 10.1016/j.jcmg.2019.06.030]
   Kawaguchi M, 2011, CIRCULATION, V123, P594, DOI 10.1161/CIRCULATIONAHA.110.982777
   Kim HK, 2021, AUTOPHAGY, V17, P761, DOI 10.1080/15548627.2020.1732161
   Kong P, 2014, CELL MOL LIFE SCI, V71, P549, DOI 10.1007/s00018-013-1349-6
   Kraker K, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-70708-5
   Kumar AA, 2019, CIRCULATION, V139, P1435, DOI 10.1161/CIRCULATIONAHA.118.036259
   Lebeaupin C, 2020, FEBS J, V287, P1722, DOI 10.1111/febs.15179
   Lehrke M, 2017, AM J MED, V130, pS40, DOI 10.1016/j.amjmed.2017.04.010
   Li C, 2020, REDOX BIOL, V36, DOI 10.1016/j.redox.2020.101659
   Mangan MSJ, 2018, NAT REV DRUG DISCOV, V17, P588, DOI [10.1038/nrd.2018.97, 10.1038/nrd.2018.149]
   Merry TL, 2020, AM J PHYSIOL-ENDOC M, V319, pE659, DOI 10.1152/ajpendo.00249.2020
   Moehlman AT, 2020, ANNU REV CELL DEV BI, V36, P265, DOI 10.1146/annurev-cellbio-021820-101354
   Paulus WJ, 2013, J AM COLL CARDIOL, V62, P263, DOI 10.1016/j.jacc.2013.02.092
   Peoples JN, 2019, EXP MOL MED, V51, DOI 10.1038/s12276-019-0355-7
   Pickles S, 2018, CURR BIOL, V28, pR170, DOI 10.1016/j.cub.2018.01.004
   Pihan P, 2017, CELL DEATH DIFFER, V24, P1478, DOI 10.1038/cdd.2017.82
   Robinson KS, 2011, ONCOGENE, V30, P2391, DOI 10.1038/onc.2010.636
   Rojas-Rivera D, 2015, ONCOGENE, V34, P269, DOI 10.1038/onc.2014.6
   Rovira-Llopis S, 2017, REDOX BIOL, V11, P637, DOI 10.1016/j.redox.2017.01.013
   Santos-Gallego CG, 2019, J AM COLL CARDIOL, V73, P1931, DOI 10.1016/j.jacc.2019.01.056
   Shadel GS, 2015, CELL, V163, P560, DOI 10.1016/j.cell.2015.10.001
   Shao BZ, 2015, FRONT PHARMACOL, V6, DOI 10.3389/fphar.2015.00262
   Song JY, 2021, NAT REV MOL CELL BIO, V22, P54, DOI 10.1038/s41580-020-00300-2
   Suetomi T, 2018, CIRCULATION, V138, P2530, DOI 10.1161/CIRCULATIONAHA.118.034621
   Tallquist MD, 2017, NAT REV CARDIOL, V14, P484, DOI 10.1038/nrcardio.2017.57
   Tong XL, 2018, MBIO, V9, DOI 10.1128/mBio.02392-17
   Verjans R, 2018, HYPERTENSION, V71, P280, DOI 10.1161/HYPERTENSIONAHA.117.10094
   Wang J, 2020, THERANOSTICS, V10, P384, DOI 10.7150/thno.40098
   Wang JY, 2020, CELL DEATH DIS, V11, DOI 10.1038/s41419-020-02777-3
   Wilcox JE, 2020, J AM COLL CARDIOL, V76, P719, DOI 10.1016/j.jacc.2020.05.075
   Willems PHGM, 2015, CELL METAB, V22, P207, DOI 10.1016/j.cmet.2015.06.006
   Wu NN, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/9825061
   Yoo SM, 2018, MOL CELLS, V41, P18, DOI 10.14348/molcells.2018.2277
   Zhang J, 2020, AGING-US, V12, P24270, DOI 10.18632/aging.202143
   Zhang JX, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/4350965
   Zhou H, 2018, CELL DEATH DIFFER, V25, P1080, DOI 10.1038/s41418-018-0086-7
NR 56
TC 11
Z9 12
U1 12
U2 29
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PD MAR 31
PY 2022
VL 2022
AR 9205908
DI 10.1155/2022/9205908
PG 33
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 2T8VQ
UT WOS:000822746200007
PM 35401934
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Liu, TY
   Song, XL
   Khan, S
   Li, Y
   Guo, ZX
   Li, CQ
   Wang, SA
   Dong, WX
   Liu, WT
   Wang, BM
   Cao, HL
AF Liu, Tianyu
   Song, Xueli
   Khan, Samiullah
   Li, Yun
   Guo, Zixuan
   Li, Chuqiao
   Wang, Sinan
   Dong, Wenxiao
   Liu, Wentian
   Wang, Bangmao
   Cao, Hailong
TI The gut microbiota at the intersection of bile acids and intestinal
   carcinogenesis: An old story, yet mesmerizing
SO INTERNATIONAL JOURNAL OF CANCER
LA English
DT Article
DE bile acid; gut microbiota; farnesoid X receptor; G protein-coupled bile
   acid receptor 1; colorectal cancer
ID PREGNANE-X-RECEPTOR; VITAMIN-D-RECEPTOR; CONSTITUTIVE ANDROSTANE
   RECEPTOR; HUMAN COLON-CANCER; INFLAMMATORY-BOWEL-DISEASE; ORPHAN NUCLEAR
   RECEPTORS; DNA-DAMAGE; HEPATOCELLULAR-CARCINOMA; URSODEOXYCHOLIC ACID;
   SALT TRANSPORTERS
AB The prevalence of colorectal cancer (CRC) has markedly increased worldwide in the last decade. Alterations of bile acid metabolism and gut microbiota have been reported to play vital roles in intestinal carcinogenesis. About trillions of bacteria have inhabited in the human gut and maintained the balance of host metabolism. Bile acids are one of numerous metabolites that are synthesized in the liver and further metabolized by the gut microbiota, and are essential in maintaining the normal gut microbiota and lipid digestion. Multiple receptors such as FXR, GPBAR1, PXR, CAR and VDR act as sensors of bile acids have been reported. In this review, we mainly discussed interplay between bile acid metabolism and gut microbiota in intestinal carcinogenesis. We then summarized the critical role of bile acids receptors involving in CRC, and also addressed the rationale of multiple interventions for CRC management by regulating bile acids-microbiota axis such as probiotics, metformin, ursodeoxycholic acid and fecal microbiota transplantation. Thus, by targeting the bile acids-microbiota axis may provide novel therapeutic modalities in CRC prevention and treatment.
C1 [Liu, Tianyu; Song, Xueli; Khan, Samiullah; Guo, Zixuan; Li, Chuqiao; Wang, Sinan; Dong, Wenxiao; Liu, Wentian; Wang, Bangmao; Cao, Hailong] Tianjin Med Univ, Gen Hosp, Dept Gastroenterol & Hepatol, Tianjin 300052, Peoples R China.
   [Li, Yun] Tianjin Med Univ, Dept Pharm, Gen Hosp, Tianjin, Peoples R China.
C3 Tianjin Medical University; Tianjin Medical University
RP Cao, HL (通讯作者)，Tianjin Med Univ, Gen Hosp, Dept Gastroenterol & Hepatol, Tianjin 300052, Peoples R China.
EM caohailong@tmu.edu.cn
RI Guo, Zixuan/GRO-5778-2022
FU National Natural Science Foundation of China [81570478, 81741075];
   Natural Science Foundation of Tianjin City [17JCYBJC24900]; Science and
   Technology Program of Tianjin, China [17ZXMFSY00210]; Tianqing Liver
   Disease Research Fund [TQGB20190103]
FX Grant sponsor: National Natural Science Foundation of China; Grant
   numbers: 81570478, 81741075; Grant sponsor: Natural Science Foundation
   of Tianjin City; Grant number: 17JCYBJC24900; Grant sponsor: Science and
   Technology Program of Tianjin, China; Grant number: 17ZXMFSY00210; Grant
   sponsor: Tianqing Liver Disease Research Fund; Grant number:
   TQGB20190103
CR Ahn J, 2013, JNCI-J NATL CANCER I, V105, P1907, DOI 10.1093/jnci/djt300
   Appleyard CB, 2011, AM J PHYSIOL-GASTR L, V301, pG1004, DOI 10.1152/ajpgi.00167.2011
   Arnold M, 2017, GUT, V66, P683, DOI 10.1136/gutjnl-2015-310912
   AXELSON M, 1990, J STEROID BIOCHEM, V36, P631, DOI 10.1016/0022-4731(90)90182-R
   Axelson M, 2000, HEPATOLOGY, V31, P1305, DOI 10.1053/jhep.2000.7877
   Bailey AM, 2014, AM J PHYSIOL-GASTR L, V306, pG48, DOI 10.1152/ajpgi.00234.2013
   BAYERDORFFER E, 1995, GUT, V36, P268, DOI 10.1136/gut.36.2.268
   Begley M, 2005, FEMS MICROBIOL REV, V29, P625, DOI 10.1016/j.femsre.2004.09.003
   Bernstein C, 2011, ARCH TOXICOL, V85, P863, DOI 10.1007/s00204-011-0648-7
   Bernstein H, 2005, MUTAT RES-REV MUTAT, V589, P47, DOI 10.1016/j.mrrev.2004.08.001
   BERR F, 1989, J CLIN INVEST, V83, P1541, DOI 10.1172/JCI114050
   Biagioli M, 2019, NUTRIENTS, V11, DOI 10.3390/nu11020325
   Biagioli M, 2017, FRONT PHARMACOL, V8, DOI 10.3389/fphar.2017.00505
   Biagioli M, 2017, J IMMUNOL, V199, P718, DOI 10.4049/jimmunol.1700183
   Booth LA, 1997, FREE RADICAL RES, V26, P135, DOI 10.3109/10715769709097792
   Brumell JH, 1999, CURR BIOL, V9, pR277, DOI 10.1016/S0960-9822(99)80178-X
   Caballeria L, 2008, BMC GASTROENTEROL, V8, DOI 10.1186/1471-230X-8-44
   Calmus Y, 2014, CLIN RES HEPATOL GAS, V38, P550, DOI 10.1016/j.clinre.2014.07.007
   Campbell JH, 2012, ISME J, V6, P2033, DOI 10.1038/ismej.2012.54
   Cani PD, 2018, NAT REV GASTRO HEPAT, V15, P671, DOI 10.1038/s41575-018-0025-6
   Cao HL, 2017, INT J CANCER, V140, P2545, DOI 10.1002/ijc.30643
   Chawla A, 2001, SCIENCE, V294, P1866, DOI 10.1126/science.294.5548.1866
   Chen XS, 2011, EXP DIABETES RES, DOI 10.1155/2011/853501
   Cheng J, 2014, J LIPID RES, V55, P455, DOI 10.1194/jlr.M044420
   Chiang JYL, 2004, J HEPATOL, V40, P539, DOI 10.1016/j.jhep.2003.11.006
   Chung HC, 2012, CELL, V149, P1578, DOI 10.1016/j.cell.2012.04.037
   Cipriani S, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0025637
   Clarke SF, 2014, GUT, V63, P1913, DOI 10.1136/gutjnl-2013-306541
   Clevers H, 2012, CELL, V149, P1192, DOI 10.1016/j.cell.2012.05.012
   Cohen DH, 2012, ENDOCR-RELAT CANCER, V19, pF27, DOI 10.1530/ERC-11-0374
   Cook J, 2013, CURR OPIN PHARMACOL, V13, P595, DOI 10.1016/j.coph.2013.05.017
   Cooke MS, 2003, FASEB J, V17, P1195, DOI 10.1096/fj.02-0752rev
   Cunningham D, 2010, LANCET, V375, P1030, DOI 10.1016/S0140-6736(10)60353-4
   De Gottardi A, 2004, DIGEST DIS SCI, V49, P982
   Degirolamo C, 2014, CELL REP, V7, P12, DOI 10.1016/j.celrep.2014.02.032
   Dong WX, 2018, J CELL MOL MED, V22, P4263, DOI 10.1111/jcmm.13709
   Dring MM, 2006, GASTROENTEROLOGY, V130, P341, DOI 10.1053/j.gastro.2005.12.008
   Duboc H, 2013, GUT, V62, P531, DOI 10.1136/gutjnl-2012-302578
   Feng Q, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms7528
   Ferrer-Mayorga G, 2019, J STEROID BIOCHEM, V185, P1, DOI 10.1016/j.jsbmb.2018.07.002
   Fiorucci S, 2018, FRONT IMMUNOL, V9, DOI 10.3389/fimmu.2018.01853
   Fiorucci S, 2015, TRENDS MOL MED, V21, P702, DOI 10.1016/j.molmed.2015.09.001
   Fiorucci S, 2009, TRENDS PHARMACOL SCI, V30, P570, DOI 10.1016/j.tips.2009.08.001
   Flemer B, 2017, GUT, V66, P633, DOI 10.1136/gutjnl-2015-309595
   FLOCH MH, 1972, AM J CLIN NUTR, V25, P1418
   Fu T, 2019, CELL, V176, P1098, DOI 10.1016/j.cell.2019.01.036
   Gadaleta RM, 2011, GUT, V60, P463, DOI 10.1136/gut.2010.212159
   Gadaleta RM, 2010, BBA-MOL CELL BIOL L, V1801, P683, DOI 10.1016/j.bbalip.2010.04.006
   Gerard Philippe, 2013, Pathogens, V3, P14, DOI 10.3390/pathogens3010014
   Glinghammar B, 2001, GASTROENTEROLOGY, V120, P401, DOI 10.1053/gast.2001.21188
   Golan MA, 2015, DIGEST DIS SCI, V60, P1941, DOI 10.1007/s10620-015-3634-8
   Grivennikov SI, 2010, CELL, V140, P883, DOI 10.1016/j.cell.2010.01.025
   Gu YY, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-01682-2
   Hara E, 2015, DIGEST DIS, V33, P346, DOI 10.1159/000371679
   Haselow K, 2013, J LEUKOCYTE BIOL, V94, P1253, DOI 10.1189/jlb.0812396
   Holmes E, 2011, TRENDS MICROBIOL, V19, P349, DOI 10.1016/j.tim.2011.05.006
   Hu X, 2014, J INTERN MED, V275, P27, DOI 10.1111/joim.12140
   Hudson GM, 2017, BRIT J PHARMACOL, V174, P1857, DOI 10.1111/bph.13787
   Hylemon PB, 2009, J LIPID RES, V50, P1509, DOI 10.1194/jlr.R900007-JLR200
   Inagaki T, 2006, P NATL ACAD SCI USA, V103, P3920, DOI 10.1073/pnas.0509592103
   Irrazabal T, 2014, MOL CELL, V54, P309, DOI 10.1016/j.molcel.2014.03.039
   Islam KBMS, 2011, GASTROENTEROLOGY, V141, P1773, DOI 10.1053/j.gastro.2011.07.046
   Jackson AL, 1998, P NATL ACAD SCI USA, V95, P12468, DOI 10.1073/pnas.95.21.12468
   Jemal A, 2011, CA-CANCER J CLIN, V61, P134, DOI [10.3322/caac.20107, 10.3322/caac.20115]
   Jia W, 2018, NAT REV GASTRO HEPAT, V15, P111, DOI 10.1038/nrgastro.2017.119
   Jin DP, 2015, CLIN THER, V37, P996, DOI 10.1016/j.clinthera.2015.04.004
   Jones BV, 2008, P NATL ACAD SCI USA, V105, P13580, DOI 10.1073/pnas.0804437105
   Joubert PE, 2009, CELL HOST MICROBE, V6, P354, DOI 10.1016/j.chom.2009.09.006
   Joyce SA, 2016, ANNU REV FOOD SCI T, V7, P313, DOI 10.1146/annurev-food-041715-033159
   Kawamata Y, 2003, J BIOL CHEM, V278, P9435, DOI 10.1074/jbc.M209706200
   Keitel V, 2008, BIOCHEM BIOPH RES CO, V372, P78, DOI 10.1016/j.bbrc.2008.04.171
   Keitel V, 2007, HEPATOLOGY, V45, P695, DOI 10.1002/hep.21458
   Keku TO, 2015, AM J PHYSIOL-GASTR L, V308, pG351, DOI 10.1152/ajpgi.00360.2012
   Kliewer SA, 1998, CELL, V92, P73, DOI 10.1016/S0092-8674(00)80900-9
   Kliewer SA, 1999, SCIENCE, V284, P757, DOI 10.1126/science.284.5415.757
   Knackstedt RW, 2013, CANCER PREV RES, V6, P585, DOI 10.1158/1940-6207.CAPR-12-0488
   Kohno H, 2007, CLIN CANCER RES, V13, P2519, DOI 10.1158/1078-0432.CCR-06-2727
   Koretz RL, 2018, AM J GASTROENTEROL, V113, P1561, DOI 10.1038/s41395-018-0249-7
   Krishnamurthy GT, 2002, J NUCL MED, V43, P1603
   Kullak-Ublick GA, 2004, GASTROENTEROLOGY, V126, P322, DOI 10.1053/j.gastro.2003.06.005
   Kurdi P, 2006, J BACTERIOL, V188, P1979, DOI 10.1128/JB.188.5.1979-1986.2006
   Langmann T, 2004, GASTROENTEROLOGY, V127, P26, DOI 10.1053/j.gastro.2004.04.019
   Lax AJ, 2005, NAT REV MICROBIOL, V3, P343, DOI 10.1038/nrmicro1130
   Lax S, 2012, INT J CANCER, V130, P2232, DOI 10.1002/ijc.26293
   Lee JM, 2014, NATURE, V516, P112, DOI 10.1038/nature13961
   Lehmann JM, 1998, J CLIN INVEST, V102, P1016, DOI 10.1172/JCI3703
   Levine B, 2011, NATURE, V469, P323, DOI 10.1038/nature09782
   Li F, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms3384
   Li TG, 2014, PHARMACOL REV, V66, P948, DOI 10.1124/pr.113.008201
   Love MW, 1998, CURR OPIN LIPIDOL, V9, P225, DOI 10.1097/00041433-199806000-00007
   Lundin A, 2008, CELL MICROBIOL, V10, P1093, DOI 10.1111/j.1462-5822.2007.01108.x
   Ma XC, 2007, J PHARMACOL EXP THER, V322, P391, DOI 10.1124/jpet.107.121913
   Maglich JM, 2002, MOL PHARMACOL, V62, P638, DOI 10.1124/mol.62.3.638
   Mahmoud NN, 1999, CARCINOGENESIS, V20, P299, DOI 10.1093/carcin/20.2.299
   Makishima M, 2002, SCIENCE, V296, P1313, DOI 10.1126/science.1070477
   Makishima M, 1999, SCIENCE, V284, P1362, DOI 10.1126/science.284.5418.1362
   MANGELSDORF DJ, 1995, CELL, V83, P835, DOI 10.1016/0092-8674(95)90199-X
   Maran RRM, 2009, J PHARMACOL EXP THER, V328, P469, DOI 10.1124/jpet.108.145409
   Martinez A, 2007, INFLAMM BOWEL DIS, V13, P1484, DOI 10.1002/ibd.20252
   Maruyama T, 2002, BIOCHEM BIOPH RES CO, V298, P714, DOI 10.1016/S0006-291X(02)02550-0
   Maruyama T, 2006, J ENDOCRINOL, V191, P197, DOI 10.1677/joe.1.06546
   Mazmanian SK, 2005, CELL, V122, P107, DOI 10.1016/j.cell.2005.05.007
   Mencarelli A, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0022978
   Miura S, 2012, BMC CANCER, V12, DOI 10.1186/1471-2407-12-56
   Modica S, 2008, CANCER RES, V68, P9589, DOI 10.1158/0008-5472.CAN-08-1791
   Moore LB, 2000, J BIOL CHEM, V275, P15122, DOI 10.1074/jbc.M001215200
   Motta JP, 2012, SCI TRANSL MED, V4, DOI 10.1126/scitranslmed.3004212
   Nagathihalli NS, 2014, CANCER RES, V74, P2062, DOI 10.1158/0008-5472.CAN-13-2329
   Nakatsu G, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms9727
   Nicholes K, 2002, AM J PATHOL, V160, P2295, DOI 10.1016/S0002-9440(10)61177-7
   O'Toole PW, 2017, NAT MICROBIOL, V2, DOI 10.1038/nmicrobiol.2017.57
   Ooi JH, 2013, J NUTR, V143, P1679, DOI 10.3945/jn.113.180794
   Otsuki M, 2000, J GASTROEN HEPATOL, V15, pD71, DOI 10.1046/j.1440-1746.2000.02178.x
   Ouyang N, 2010, BRIT J CANCER, V102, P1753, DOI 10.1038/sj.bjc.6605677
   Paramsothy S, 2019, GASTROENTEROLOGY, V156, P1440, DOI 10.1053/j.gastro.2018.12.001
   Parks DJ, 1999, SCIENCE, V284, P1365, DOI 10.1126/science.284.5418.1365
   Pearson T, 2019, CANCER MED-US, V8, P617, DOI 10.1002/cam4.1965
   Pereira MA, 2004, CANCER LETT, V212, P145, DOI 10.1016/j.canlet.2004.03.024
   Perides G, 2010, GASTROENTEROLOGY, V138, P715, DOI 10.1053/j.gastro.2009.10.052
   Piglionica M, 2018, CURR OPIN PHARMACOL, V43, P93, DOI 10.1016/j.coph.2018.08.005
   Pols TWH, 2011, CELL METAB, V14, P747, DOI 10.1016/j.cmet.2011.11.006
   PoolZobel BL, 1997, MUTAT RES-FUND MOL M, V375, P105, DOI 10.1016/S0027-5107(97)00006-7
   Qin N, 2014, NATURE, V513, P59, DOI 10.1038/nature13568
   Qiu ZJ, 2016, SCI REP-UK, V6, DOI 10.1038/srep31936
   Ridlon JM, 2016, GUT MICROBES, V7, P201, DOI 10.1080/19490976.2016.1150414
   Ridlon JM, 2013, GUT MICROBES, V4, P382, DOI 10.4161/gmic.25723
   Ridlon JM, 2006, J LIPID RES, V47, P241, DOI 10.1194/jlr.R500013-JLR200
   Rosshart SP, 2017, CELL, V171, P1015, DOI 10.1016/j.cell.2017.09.016
   Rossi O, 2016, SCI REP-UK, V6, DOI 10.1038/srep18507
   Rossocha M, 2005, BIOCHEMISTRY-US, V44, P5739, DOI 10.1021/bi0473206
   Round JL, 2010, P NATL ACAD SCI USA, V107, P12204, DOI 10.1073/pnas.0909122107
   Rubinstein MR, 2013, CELL HOST MICROBE, V14, P195, DOI 10.1016/j.chom.2013.07.012
   Saini SPS, 2004, MOL PHARMACOL, V65, P292, DOI 10.1124/mol.65.2.292
   Sayin SI, 2013, CELL METAB, V17, P225, DOI 10.1016/j.cmet.2013.01.003
   Sears CL, 2014, CELL HOST MICROBE, V15, P317, DOI 10.1016/j.chom.2014.02.007
   Selmin OI, 2016, J NUTR, V146, P236, DOI 10.3945/jn.115.216580
   Sender R, 2016, CELL, V164, P337, DOI 10.1016/j.cell.2016.01.013
   Serfaty L, 2003, HEPATOLOGY, V38, P203, DOI 10.1053/jhep.2003.50311
   Shah YM, 2007, AM J PHYSIOL-GASTR L, V292, pG1114, DOI 10.1152/ajpgi.00528.2006
   Sheikh SZ, 2010, CURR OPIN GASTROEN, V26, P578, DOI 10.1097/MOG.0b013e32833d4b71
   Shinnoh M, 2013, INT J ONCOL, V42, P903, DOI 10.3892/ijo.2013.1790
   Sica A, 2008, CANCER LETT, V267, P204, DOI 10.1016/j.canlet.2008.03.028
   Smith DLH, 2010, CARCINOGENESIS, V31, P1100, DOI 10.1093/carcin/bgq050
   Song C, 2000, STEROIDS, V65, P423, DOI 10.1016/S0039-128X(00)00127-6
   Staudinger JL, 2001, P NATL ACAD SCI USA, V98, P3369, DOI 10.1073/pnas.051551698
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Sun M, 2015, MUCOSAL IMMUNOL, V8, P969, DOI 10.1038/mi.2015.49
   Talero E, 2015, INFLAMM BOWEL DIS, V21, P1027, DOI 10.1097/MIB.0000000000000346
   Tang WHW, 2014, J CLIN INVEST, V124, P4204, DOI 10.1172/JCI72331
   Thomas C, 2008, NAT REV DRUG DISCOV, V7, P678, DOI 10.1038/nrd2619
   Torres J, 2013, INFLAMM BOWEL DIS, V19, P275, DOI 10.1097/MIB.0b013e318286ff2e
   Trauner M, 2003, PHYSIOL REV, V83, P633, DOI 10.1152/physrev.00027.2002
   Trinchieri V, 2017, FRONT IMMUNOL, V8, DOI 10.3389/fimmu.2017.01474
   Tsilimigras MCB, 2017, NAT MICROBIOL, V2, DOI 10.1038/nmicrobiol.2017.8
   Tsoi H, 2017, GASTROENTEROLOGY, V152, P1419, DOI 10.1053/j.gastro.2017.01.009
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Vavassori P, 2009, J IMMUNOL, V183, P6251, DOI 10.4049/jimmunol.0803978
   Venkatesh M, 2014, IMMUNITY, V41, P296, DOI 10.1016/j.immuni.2014.06.014
   Wada K, 2009, ONCOL REP, V22, P1021, DOI 10.3892/or_00000530
   Wahlstrom A, 2016, CELL METAB, V24, P41, DOI 10.1016/j.cmet.2016.05.005
   Wang HB, 1999, MOL CELL, V3, P543, DOI 10.1016/S1097-2765(00)80348-2
   Wang HW, 2011, J CLIN INVEST, V121, P3220, DOI 10.1172/JCI41514
   Wang K, 2019, CELL REP, V26, P222, DOI 10.1016/j.celrep.2018.12.028
   Wang L, 2002, DEV CELL, V2, P721, DOI 10.1016/S1534-5807(02)00187-9
   Wang SA, 2019, MOL CARCINOGEN, V58, P1155, DOI 10.1002/mc.22999
   Wang TT, 2012, ISME J, V6, P320, DOI 10.1038/ismej.2011.109
   Wei P., 2002, Pharmacogenomics Journal, V2, P117, DOI 10.1038/sj.tpj.6500087
   Wei P, 2000, NATURE, V407, P920, DOI 10.1038/35038112
   WEISBURGER JH, 1975, P SOC EXP BIOL MED, V148, P1119
   Wong SH, 2017, GASTROENTEROLOGY, V153, P1621, DOI 10.1053/j.gastro.2017.08.022
   Woo TDH, 2011, J MED MICROBIOL, V60, P1617, DOI 10.1099/jmm.0.033423-0
   Wright EK, 2015, INFLAMM BOWEL DIS, V21, P1219, DOI 10.1097/MIB.0000000000000382
   Wu SG, 2009, NAT MED, V15, P1016, DOI 10.1038/nm.2015
   Wu SP, 2015, AM J PHYSIOL-GASTR L, V309, pG341, DOI 10.1152/ajpgi.00105.2015
   Xie W, 2000, GENE DEV, V14, P3014, DOI 10.1101/gad.846800
   Yoneno K, 2013, IMMUNOLOGY, V139, P19, DOI 10.1111/imm.12045
   Yu TC, 2017, CELL, V170, P548, DOI 10.1016/j.cell.2017.07.008
   Yuhara H, 2011, AM J GASTROENTEROL, V106, P1911, DOI 10.1038/ajg.2011.301
   Zeller G, 2014, MOL SYST BIOL, V10, DOI 10.15252/msb.20145645
   Zhang Y, 2018, MOL NUTR FOOD RES, V62, DOI 10.1002/mnfr.201700554
   Zheng W, 2012, INT J CANCER, V130, P10, DOI 10.1002/ijc.25992
   Zhou J, 2008, MOL ENDOCRINOL, V22, P868, DOI 10.1210/me.2007-0197
NR 182
TC 57
Z9 61
U1 2
U2 66
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0020-7136
EI 1097-0215
J9 INT J CANCER
JI Int. J. Cancer
PD APR 1
PY 2020
VL 146
IS 7
BP 1780
EP 1790
DI 10.1002/ijc.32563
EA JUL 2019
PG 11
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA KG5VV
UT WOS:000479418200001
PM 31291465
OA Bronze
DA 2023-06-08
ER

PT J
AU Yin, W
   Zhang, SQ
   Pang, WL
   Chen, XJ
   Wen, J
   Hou, J
   Wang, C
   Song, LY
   Qiu, ZM
   Liang, PT
   Yuan, JL
   Yang, ZS
   Bian, Y
AF Yin, Wen
   Zhang, Si-Qi
   Pang, Wen-Lin
   Chen, Xiao-Jiao
   Wen, Jing
   Hou, Jiong
   Wang, Cui
   Song, Li-Yun
   Qiu, Zhen-Ming
   Liang, Peng-Tao
   Yuan, Jia-Li
   Yang, Zhong-Shan
   Bian, Yao
TI Tang-Ping-San Decoction Remodel Intestinal Flora and Barrier to
   Ameliorate Type 2 Diabetes Mellitus in Rodent Model
SO DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
LA English
DT Article
DE type 2 diabetes mellitus; tang-ping-san decoction; gut microbiota;
   glycolipid metabolism; insulin resistance
ID GUT MICROBIOTA; INSULIN-RESISTANCE; AKKERMANSIA-MUCINIPHILA; OBESITY;
   INFLAMMATION; PREVENTION; STEATOSIS; METFORMIN; CURCUMIN; DISEASE
AB Purpose: Type 2 diabetes mellitus (T2DM) is a complex genetic disease associated with genetic and environmental factors. Previous studies have shown that changes in the gut microbiota may affect the development of host metabolic diseases and promote the progression of T2DM. Tang-ping-san (TPS) decoction can effectively treat T2DM. However, its specific mechanisms must be evaluated.
   Patients and Methods: In the present study, we established an animal model of T2DM using a high-fat diet (HFD) with intraperitoneal injection streptozotocin injection.
   Results: The therapeutic effect of TPS decoction on T2DM in mice was initially evaluated. TPS decoction was found to improve hyperglycemia, hyperlipidemia, insulin resistance, and pathological liver, pancreatic, and colon changes. Moreover, it reduced the proin-flammatory cytokine levels. Based on 16SrRNA sequencing, TPS decoction reduced the Fitmicutes/Bacteroidetes ratio at the phylum level. At the genus level, it increased the relative abundances of Akkermansia, Muribaculaceae, and the Eubacterium coprostanoligenes group and decreased the relative abundance of Fusobacterium, Escherichia coli, Dubosiella, and Helicobacter.
   Conclusion: TPS decoction improves T2DM and liver function and reduces the risk of hyperglycemia, hyperlipidemia, insulin resistance, pathological organ changes, and inflammatory reactions. The mechanism of TPS decoction in T2DM can be correlated with the reversal of gut microbiota dysfunction and repair of the intestinal mucosal barrier.
C1 [Yin, Wen; Zhang, Si-Qi; Pang, Wen-Lin; Chen, Xiao-Jiao; Wen, Jing; Hou, Jiong; Wang, Cui; Song, Li-Yun; Qiu, Zhen-Ming; Liang, Peng-Tao; Yuan, Jia-Li; Yang, Zhong-Shan; Bian, Yao] Yunnan Univ Chinese Med, Yunnan Prov Key Lab Mol Biol Sinomed, Kunming, Yunnan, Peoples R China.
   [Yang, Zhong-Shan; Bian, Yao] Yunnan Univ Chinese Med, Kunming, Yunnan, Peoples R China.
C3 Yunnan University of Chinese Medicine; Yunnan University of Chinese
   Medicine
RP Yang, ZS; Bian, Y (通讯作者)，Yunnan Univ Chinese Med, Yunnan Prov Key Lab Mol Biol Sinomed, Kunming, Yunnan, Peoples R China.; Yang, ZS; Bian, Y (通讯作者)，Yunnan Univ Chinese Med, Kunming, Yunnan, Peoples R China.
EM yangzhongshan@ynutcm.edu.cn; 1345538930@qq.com
OI Yang, ZhongShan/0000-0002-5270-0119
FU National Natural Science Foundation of China [81860646]; Yunnan
   Provincial Science and Technology Department [202201AS070084,
   202101AZ070001-012, 2019FI016, 202005AC160058, 202105AF150031, YB220309,
   30170104891]
FX Acknowledgments This research was supported by National Natural Science
   Foundation of China (81860646) and a grant from Yunnan Provincial
   Science and Technology Department (202201AS070084, 202101AZ070001-012,
   2019FI016, 202005AC160058, 202105AF150031, YB220309, 30170104891) .
CR Amir A, 2017, MSYSTEMS, V2, DOI 10.1128/mSystems.00191-16
   Baek SM, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-73994-1
   Brahe LK, 2015, NUTR DIABETES, V5, DOI 10.1038/nutd.2015.9
   Callahan BJ, 2019, NUCLEIC ACIDS RES, V47, DOI 10.1093/nar/gkz569
   Callahan BJ, 2016, NAT METHODS, V13, P581, DOI [10.1038/NMETH.3869, 10.1038/nmeth.3869]
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   Chavez-Carbajal A, 2020, MICROORGANISMS, V8, DOI 10.3390/microorganisms8010094
   Chen MY, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.02380
   Chen PC, 2019, NUTRITION, V63-64, P51, DOI 10.1016/j.nut.2018.11.019
   Chen XL, 2018, EUR REV MED PHARMACO, V22, P5640, DOI 10.26355/eurrev_201809_15830
   Cheung SG, 2019, FRONT PSYCHIATRY, V10, DOI 10.3389/fpsyt.2019.00034
   Chuengsamarn S, 2012, DIABETES CARE, V35, P2121, DOI 10.2337/dc12-0116
   Depommier C, 2019, NAT MED, V25, P1096, DOI 10.1038/s41591-019-0495-2
   Derrien M, 2004, INT J SYST EVOL MICR, V54, P1469, DOI 10.1099/ijs.0.02873-0
   Dibe HA, 2020, PHYSIOL REP, V8, DOI 10.14814/phy2.14370
   Everard A, 2013, BEST PRACT RES CL GA, V27, P73, DOI 10.1016/j.bpg.2013.03.007
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Fan YB, 2018, BIOMED PHARMACOTHER, V106, P733, DOI 10.1016/j.biopha.2018.06.089
   Fassatoui M, 2019, BIOSCIENCE REP, V39, DOI 10.1042/BSR20182348
   Fedorak RN, 2012, CAN J GASTROENTEROL, V26, P252, DOI 10.1155/2012/861478
   Gong P, 2021, J ETHNOPHARMACOL, V281, DOI 10.1016/j.jep.2021.114558
   Guo CL, 2021, INT J BIOL MACROMOL, V181, P357, DOI 10.1016/j.ijbiomac.2021.03.137
   Hagan T, 2019, CELL, V178, P1313, DOI 10.1016/j.cell.2019.08.010
   Halawa MR, 2019, CURR DIABETES REV, V15, P480, DOI 10.2174/1573399815666190206162143
   Higuchi I, 2020, DRUG METAB PHARMACOK, V35, P131, DOI 10.1016/j.dmpk.2019.10.001
   Huang S, 2014, J DIABETES RES, V2014, DOI 10.1155/2014/717219
   Huda MN, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.632335
   Jasirwan COM, 2021, BIOSCI MICROB FOOD H, V40, P50, DOI 10.12938/bmfh.2020-046
   Joyce SA, 2017, DIGEST DIS, V35, P169, DOI 10.1159/000450907
   Kong WJ, 2009, METABOLISM, V58, P109, DOI 10.1016/j.metabol.2008.08.013
   Lee JH, 2022, J MICROBIOL, V60, P215, DOI 10.1007/s12275-022-1649-3
   Liu JL, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21030910
   Mendes JJ, 2012, COMPARATIVE MED, V62, P37
   Nascimento JC, 2021, DIGEST DIS SCI, V66, P3359, DOI 10.1007/s10620-020-06664-x
   Neish AS, 2009, GASTROENTEROLOGY, V136, P65, DOI 10.1053/j.gastro.2008.10.080
   Ortega MA, 2020, NUTRIENTS, V12, DOI 10.3390/nu12092749
   Pahlavani M, 2017, J INVEST MED, V65, P1021, DOI 10.1136/jim-2017-000535
   Pang B, 2017, DIABETES RES CLIN PR, V131, P242, DOI 10.1016/j.diabres.2017.07.020
   Pasini E, 2019, MINERVA MED, V110, P3, DOI 10.23736/S0026-4806.18.05589-1
   Qiao SS, 2020, CELL REP, V32, DOI 10.1016/j.celrep.2020.108005
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Qin JJ, 2010, NATURE, V464, P59, DOI 10.1038/nature08821
   Rivera-Mancia S, 2015, EUR J PHARMACOL, V756, P30, DOI 10.1016/j.ejphar.2015.02.045
   Rotter V, 2003, J BIOL CHEM, V278, P45777, DOI 10.1074/jbc.M301977200
   Saeedi P, 2020, DIABETES RES CLIN PR, V162, DOI 10.1016/j.diabres.2020.108086
   Sedighi M, 2017, MICROB PATHOGENESIS, V111, P362, DOI 10.1016/j.micpath.2017.08.038
   Senn JJ, 2002, DIABETES, V51, P3391, DOI 10.2337/diabetes.51.12.3391
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Stojanov S, 2020, MICROORGANISMS, V8, DOI 10.3390/microorganisms8111715
   Tanase DM, 2020, NUTRIENTS, V12, DOI 10.3390/nu12123719
   Tilg H, 2014, GUT, V63, P1513, DOI 10.1136/gutjnl-2014-306928
   Vallianou NG, 2018, DIABETES RES CLIN PR, V146, P111, DOI 10.1016/j.diabres.2018.10.008
   Wang C, 2022, J ADV RES, V36, P27, DOI 10.1016/j.jare.2021.06.012
   Wang JH, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00620
   Wei W, 2021, CLIN NUTR, V40, P4234, DOI 10.1016/j.clnu.2021.01.031
   Wolf P, 2014, WIEN MED WOCHENSCHR, V164, P320, DOI 10.1007/s10354-014-0292-y
   Wu W, 2019, FASEB J, V33, P12616, DOI 10.1096/fj.201901061R
   Wu XK, 2010, CURR MICROBIOL, V61, P69, DOI 10.1007/s00284-010-9582-9
   Xia F, 2021, WORLD J DIABETES, V12, P1146, DOI 10.4239/wjd.v12.i8.1146
   Yan HL, 2017, PHYTOMEDICINE, V26, P45, DOI 10.1016/j.phymed.2017.01.007
   Yang CM, 2010, J CELL PHYSIOL, V224, P516, DOI 10.1002/jcp.22153
   Zhai Z, 2021, FRONT MICROBIOL, V12, DOI 10.3389/fmicb.2021.727681
   Zhang PP, 2020, ACTA PHARMACOL SIN, V41, P678, DOI 10.1038/s41401-019-0330-9
   Zhang Q, 2020, DIABET METAB SYND OB, V13, P5003, DOI 10.2147/DMSO.S286430
   Zhang RX, 2004, J ETHNOPHARMACOL, V90, P39, DOI 10.1016/j.jep.2003.09.018
   Zhang SS, 2022, FOOD FUNCT, V13, P3931, DOI [10.1039/D1FO04170C, 10.1039/d1fo04170c]
   Zhang W, 2019, BIOMED PHARMACOTHER, V118, DOI 10.1016/j.biopha.2019.109131
   Zheng P, 2016, MOL PSYCHIATR, V21, P786, DOI 10.1038/mp.2016.44
   Zhu YB, 2019, ARTIF CELL NANOMED B, V47, P4172, DOI 10.1080/21691401.2019.1687492
NR 71
TC 4
Z9 3
U1 7
U2 12
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7007
J9 DIABET METAB SYND OB
JI Diabetes Metab. Syndr. Obes.
PY 2022
VL 15
BP 2563
EP 2581
DI 10.2147/DMSO.S375572
PG 19
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 3Y7YF
UT WOS:000843937400001
PM 36035516
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Gabel, SA
   Duff, MR
   Pedersen, LC
   DeRose, EF
   Krahn, JM
   Howell, EE
   London, RE
AF Gabel, Scott A.
   Duff, Michael R.
   Pedersen, Lars C.
   DeRose, Eugene F.
   Krahn, Juno M.
   Howell, Elizabeth E.
   London, Robert E.
TI A Structural Basis for Biguanide Activity
SO BIOCHEMISTRY
LA English
DT Article
ID ONE-CARBON METABOLISM; DIHYDROFOLATE-REDUCTASE; HOMOCYSTEINE LEVELS;
   LIGAND-BINDING; METFORMIN; FOLATE; DRUG; INHIBITORS; MECHANISM; GLUCOSE
AB Metformin is the most commonly prescribed treatment for type II diabetes and related disorders; however, molecular insights into its mode(s) of action have been limited by an absence of structural data. Structural considerations along with a growing body of literature demonstrating its effects on one-carbon metabolism suggest the possibility of folate mimicry and anti-folate activity. Motivated by the growing recognition that anti-diabetic biguanides may act directly upon the gut microbiome, we have determined structures of the complexes formed between the anti-diabetic biguanides (phenformin, buformin, and metformin) and Escherichia coli dihydrofolate reductase (ecDHFR) based on nuclear magnetic resonance, crystallographic, and molecular modeling studies. Interligand Overhauser effects indicate that metformin can form ternary complexes with p-aminobenzoyl-L-glutamate (pABG) as well as other ligands that occupy the region of the folate-binding site that interacts with pABG; however, DHFR inhibition is not cooperative. The biguanides competitively inhibit the activity of ecDHFR, with the phenformin inhibition constant being 100-fold lower than that of metformin. This inhibition may be significant at concentrations present in the gut of treated individuals, and inhibition of DHFR in intestinal mucosal cells may also occur if accumulation levels are sufficient. Perturbation of folate homeostasis can alter the pyridine nucleotide redox ratios that are important regulators of cellular metabolism.
C1 [Gabel, Scott A.; Pedersen, Lars C.; DeRose, Eugene F.; Krahn, Juno M.; London, Robert E.] NIEHS, Genome Integr & Struct Biol Lab, NIH, 111 TW Alexander Dr, Res Triangle Pk, NC 27709 USA.
   [Duff, Michael R.; Howell, Elizabeth E.] Univ Tennessee, Dept Biochem & Cellular & Mol Biol, Knoxville, TN 37996 USA.
C3 National Institutes of Health (NIH) - USA; NIH National Institute of
   Environmental Health Sciences (NIEHS); University of Tennessee System;
   University of Tennessee Knoxville
RP London, RE (通讯作者)，NIEHS, Genome Integr & Struct Biol Lab, NIH, MR-01, Res Triangle Pk, NC 27709 USA.
EM london@niehs.nih.gov
RI London, Robert E/F-7990-2019; Pedersen, Lars C/C-6173-2019
OI London, Robert E/0000-0001-9108-8463; Pedersen, Lars
   C/0000-0002-4488-4077; Howell, Elizabeth/0000-0001-6157-433X
FU Intramural NIH HHS [Z01 ES050111-19, ZIA ES102645-08] Funding Source:
   Medline; NIEHS NIH HHS [ZIA ES050111, ZIA ES102645] Funding Source:
   Medline; NIGMS NIH HHS [R15 GM110669] Funding Source: Medline
CR Aarsand AK, 1998, J INTERN MED, V244, P169
   Adams PD, 2010, ACTA CRYSTALLOGR D, V66, P213, DOI 10.1107/S0907444909052925
   ALLEGRA CJ, 1985, J BIOL CHEM, V260, P9720
   Bag S, 2010, J ENZYM INHIB MED CH, V25, P331, DOI 10.3109/14756360903179443
   Bailey CJ, 2008, DIABETOLOGIA, V51, P1552, DOI 10.1007/s00125-008-1053-5
   Bailey CJ, 1996, NEW ENGL J MED, V334, P574, DOI 10.1056/NEJM199602293340906
   Bailey SW, 2009, P NATL ACAD SCI USA, V106, P15424, DOI 10.1073/pnas.0902072106
   Barsukov IL, 1996, J MOL BIOL, V262, P543, DOI 10.1006/jmbi.1996.0534
   Bauer PV, 2016, J ENDOCRINOL, V230, pR95, DOI 10.1530/JOE-16-0056
   Beckers A, 2006, MOL CANCER THER, V5, P2211, DOI 10.1158/1535-7163.MCT-06-0001
   Beierlein JM, 2009, BIOCHEMISTRY-US, V48, P4100, DOI 10.1021/bi802319w
   BIRDSALL B, 1978, BIOCHEMISTRY-US, V17, P2102, DOI 10.1021/bi00604a013
   Bot CT, 2010, BIOPHYS CHEM, V146, P133, DOI 10.1016/j.bpc.2009.11.005
   BOWDEN K, 1989, BIOCHEM J, V258, P335, DOI 10.1042/bj2580335
   Bridges HR, 2014, BIOCHEM J, V462, P475, DOI 10.1042/BJ20140620
   Cabreiro F, 2013, CELL, V153, P228, DOI 10.1016/j.cell.2013.02.035
   Canto C, 2009, NATURE, V458, P1056, DOI 10.1038/nature07813
   Carlsen SM, 1997, SCAND J CLIN LAB INV, V57, P521, DOI 10.3109/00365519709084603
   CAYLEY PJ, 1981, BIOCHEMISTRY-US, V20, P874, DOI 10.1021/bi00507a034
   Chien HC, 2016, DRUG METAB DISPOS, V44, P356, DOI 10.1124/dmd.115.066647
   Chopra S, 2008, J BIOL CHEM, V283, P4690, DOI 10.1074/jbc.M709443200
   Cicero AFG, 2012, ARCH MED SCI, V8, P907, DOI 10.5114/aoms.2012.31622
   Corominas-Faja B, 2012, AGING-US, V4, P480, DOI 10.18632/aging.100472
   Dasgupta T, 2009, ACS CHEM BIOL, V4, P29, DOI 10.1021/cb8002804
   DAVIDOFF F, 1971, J BIOL CHEM, V246, P4017
   DELAGLIO F, 1995, J BIOMOL NMR, V6, P277, DOI 10.1007/BF00197809
   DENNO KM, 1994, TERATOLOGY, V49, P260, DOI 10.1002/tera.1420490405
   Dowling RJO, 2007, CANCER RES, V67, P10804, DOI 10.1158/0008-5472.CAN-07-2310
   Dowling RJO, 2011, BMC MED, V9, DOI 10.1186/1741-7015-9-33
   Emsley P, 2010, ACTA CRYSTALLOGR D, V66, P486, DOI 10.1107/S0907444910007493
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Frisch M. J., 2009, GAUSSIAN 09 E1
   GARDNER MLG, 1977, Q J EXP PHYSIOL CMS, V62, P247, DOI 10.1113/expphysiol.1977.sp002396
   LeBlanc JG, 2013, CURR OPIN BIOTECH, V24, P160, DOI 10.1016/j.copbio.2012.08.005
   Han TX, 2015, J PHARMACOL EXP THER, V352, P519, DOI 10.1124/jpet.114.220350
   Haupt VJ, 2013, PLOS ONE, V8, DOI [10.1371/journal.pone.0065894, 10.1371/journal.pone.0059937]
   Houtman JCD, 2007, PROTEIN SCI, V16, P30, DOI 10.1110/ps.062558507
   Janzer A, 2014, P NATL ACAD SCI USA, V111, P10574, DOI 10.1073/pnas.1409844111
   JOHNSON BA, 1994, J BIOMOL NMR, V4, P603, DOI 10.1007/BF00404272
   Kang KY, 2013, INT IMMUNOPHARMACOL, V16, P85, DOI 10.1016/j.intimp.2013.03.020
   Kapilashrami K, 2013, J BIOL CHEM, V288, P6045, DOI 10.1074/jbc.M112.414516
   Kopp M, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.00445
   KRUGER FA, 1970, DIABETES, V19, P50, DOI 10.2337/diab.19.1.50
   Kupce E, 1996, J MAGN RESON SER A, V118, P299, DOI 10.1006/jmra.1996.0042
   Kwon YK, 2008, NAT CHEM BIOL, V4, P602, DOI 10.1038/nchembio.108
   Lamb KM, 2014, ANTIMICROB AGENTS CH, V58, P7484, DOI 10.1128/AAC.03555-14
   Li DW, 1999, J BIOMOL NMR, V15, P71, DOI 10.1023/A:1008360208627
   Li WN, 2014, EXP THER MED, V7, P389, DOI 10.3892/etm.2013.1416
   London RE, 1999, J MAGN RESON, V141, P301, DOI 10.1006/jmre.1999.1897
   Lord JM, 2003, BRIT MED J, V327, P951, DOI 10.1136/bmj.327.7421.951
   Madiraju AK, 2014, NATURE, V510, P542, DOI 10.1038/nature13270
   Matherly LH, 2007, CANCER METAST REV, V26, P111, DOI 10.1007/s10555-007-9046-2
   Mayer S, 2004, J COMB CHEM, V6, P776, DOI 10.1021/cc049953+
   Mccoy AJ, 2007, J APPL CRYSTALLOGR, V40, P658, DOI 10.1107/S0021889807021206
   McCreight LJ, 2016, DIABETOLOGIA, V59, P426, DOI 10.1007/s00125-015-3844-9
   Menendez JA, 2012, AGING-US, V4, P894
   Orchard TJ, 2005, ANN INTERN MED, V142, P611, DOI 10.7326/0003-4819-142-8-200504190-00009
   Otwinowski Z, 1997, METHOD ENZYMOL, V276, P307, DOI 10.1016/S0076-6879(97)76066-X
   Ouyang JY, 2011, J BIOL CHEM, V286, P1, DOI 10.1074/jbc.M110.121806
   Owen MR, 2000, BIOCHEM J, V348, P607, DOI 10.1042/0264-6021:3480607
   Patanwala I, 2014, AM J CLIN NUTR, V100, P593, DOI 10.3945/ajcn.113.080507
   PENNER MH, 1985, J BIOL CHEM, V260, P5366
   Pernicova I, 2014, NAT REV ENDOCRINOL, V10, P143, DOI 10.1038/nrendo.2013.256
   Pero RW, 2010, CURR CLIN PHARMACOL, V5, P67, DOI 10.2174/157488410790410588
   Pirkmajer S, 2015, DIABETES, V64, P360, DOI 10.2337/db14-0508
   Proctor WR, 2008, DRUG METAB DISPOS, V36, P1650, DOI 10.1124/dmd.107.020180
   Rosilio C, 2014, CANCER LETT, V346, P188, DOI 10.1016/j.canlet.2014.01.006
   Salani B, 2013, SCI REP-UK, V3, DOI 10.1038/srep02070
   Samart N, 2014, LANGMUIR, V30, P8697, DOI 10.1021/la501600s
   Sawabe K, 2004, J PHARMACOL SCI, V96, P124, DOI 10.1254/jphs.FP0040280
   Sawaya MR, 1997, BIOCHEMISTRY-US, V36, P586, DOI 10.1021/bi962337c
   SCHIRCH V, 1989, ARCH BIOCHEM BIOPHYS, V269, P371, DOI 10.1016/0003-9861(89)90120-3
   Segel I.H, 1975, ENZYME KINETICS
   Shaw RJ, 2005, SCIENCE, V310, P1642, DOI 10.1126/science.1120781
   Smiley RD, 2004, ANAL BIOCHEM, V334, P204, DOI 10.1016/j.ab.2004.06.040
   Stepensky D, 2002, DRUG METAB DISPOS, V30, P861, DOI 10.1124/dmd.30.8.861
   Summerfield RL, 2006, J MED CHEM, V49, P6977, DOI 10.1021/jm060570v
   Tedeschi PM, 2015, CANCER METAB, V3, DOI 10.1186/s40170-015-0132-6
   Tilg H, 2014, GUT, V63, P1513, DOI 10.1136/gutjnl-2014-306928
   Vanichtanankul J, 2012, ANTIMICROB AGENTS CH, V56, P3928, DOI 10.1128/AAC.00301-12
   Vreven T, 2006, J CHEM THEORY COMPUT, V2, P815, DOI 10.1021/ct050289g
   Wulffele MG, 2003, J INTERN MED, V254, P455, DOI 10.1046/j.1365-2796.2003.01213.x
   Yin YM, 2015, SCI TRANSL MED, V7, DOI 10.1126/scitranslmed.aaa0835
   YONETANI T, 1964, ARCH BIOCHEM BIOPHYS, V106, P243, DOI 10.1016/0003-9861(64)90184-5
   Zhang YL, 1998, ANAL BIOCHEM, V261, P139, DOI 10.1006/abio.1998.2738
   Zhao HY, 2015, METHODS, V76, P137, DOI 10.1016/j.ymeth.2014.11.012
   Zhou GC, 2001, J CLIN INVEST, V108, P1167, DOI 10.1172/JCI200113505
   Zwahlen C, 1998, J AM CHEM SOC, V120, P7617, DOI 10.1021/ja981205z
NR 88
TC 16
Z9 18
U1 0
U2 19
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0006-2960
J9 BIOCHEMISTRY-US
JI Biochemistry
PD SEP 12
PY 2017
VL 56
IS 36
BP 4786
EP 4798
DI 10.1021/acs.biochem.7b00619
PG 13
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA FH0YW
UT WOS:000410867600010
PM 28766937
OA Green Accepted
DA 2023-06-08
ER

PT J
AU Shen, D
   Lu, YJ
   Tian, SH
   Ma, ST
   Sun, J
   Hu, QB
   Pang, XY
   Li, XF
AF Shen, Dan
   Lu, Yingjian
   Tian, Shuhua
   Ma, Shaotong
   Sun, Jing
   Hu, Qiaobin
   Pang, Xinyi
   Li, Xiangfei
TI Effects of L-arabinose by hypoglycemic and modulating gut microbiome in
   a high-fat diet- and streptozotocin-induced mouse model of type 2
   diabetes mellitus
SO JOURNAL OF FOOD BIOCHEMISTRY
LA English
DT Article
DE blood glucose; insulin sensitivity; L-arabinose; oxidative stress; serum
   lipid
ID GLUCOSE-METABOLISM; INTESTINAL SUCRASE; OXIDATIVE STRESS; METFORMIN;
   INSULIN; MICE; GLUCONEOGENESIS; INCREASES; SUCROSE; TARGETS
AB L-arabinose is a good and healthy food additive. This study was conducted to investigate the effect of L-arabinose in a mouse model of type 2 diabetes mellitus (T2DM) induced by exposure to a high-fat diet (HFD) and streptozotocin (STZ). The model mice received L-arabinose at 20 and 60 mg (kg body weight [bw])(-1)d(-1), metformin at 300 mg (kg bw)(-1)d(-1) (positive control) or sterile water (control) via oral gavage. Compared with the model group, mice treated with L-arabinose exhibited attenuated symptoms of diabetes mellitus, including a slower rate of body weight loss, increased homeostasis model assessment of beta-cell function index levels, decreased blood glucose, alleviation of steatosis, and repair of pancreatic islet cells. L-arabinose also exerted an anti-inflammatory effect and partially mitigated dyslipidemia. A 16S-rRNA sequence analysis of the gut microbiota revealed that at the phylum level, treatment with L-arabinose significantly reduced the ratio of Firmicutes to Bacteroidetes due to a decreased relative abundance of Firmicutes; at the genus level, it reversed the increase in the relative abundance of Allobaculum and the decrease abundance of Oscillospira caused by exposure to an HFD and STZ. And the model mice received L-arabinose at 20 mg (kg bw)(-1)d(-1) had a better effect on improving T2DM than the high-dose group supplemented L-arabinose at 60 mg (kg bw)(-1)d(-1). These results strongly suggest L-arabinose as an excellent candidate supplement to prevent or treat T2DM. Practical applications L-arabinose, xylitol and sucralose are well-known substitutes for sucrose. L-arabinose has been reported to have beneficial effects on hyperglycemia, glycemic index, and fat accumulation. In this study, we found that low-dose (20 mg (kg bw)(-1)d(-1)) supplementation of L-arabinose significantly improved glucose intolerance and gut microbiota incoordination in T2DM caused by HFD and STZ.
C1 [Shen, Dan; Lu, Yingjian; Tian, Shuhua; Ma, Shaotong; Sun, Jing; Hu, Qiaobin; Pang, Xinyi; Li, Xiangfei] Nanjing Univ Finance & Econ, Coll Food Sci & Engn, Nanjing 210023, Peoples R China.
C3 Nanjing University of Finance & Economics
RP Li, XF (通讯作者)，Nanjing Univ Finance & Econ, Coll Food Sci & Engn, Nanjing 210023, Peoples R China.
EM xiangfeili@nufe.edu.cn
OI Li, Xiangfei/0000-0001-7258-295X; Shen, Dan/0000-0001-8655-0166
FU China Postdoctoral Science Foundation [2020M671517]; Natural Science
   Foundation of Jiangsu Province [SBK2018042932]; Priority Academic
   Program Development of Jiangsu Higher Education Institutions; National
   Natural Science Foundation of China [31801545]; Open project of China
   Canada food nutrition and health Joint Laboratory [ZJ-2020-07]
FX China Postdoctoral Science Foundation funded project, Grant/Award
   Number: 2020M671517; Natural Science Foundation of Jiangsu Province,
   Grant/Award Number: SBK2018042932; Priority Academic Program Development
   of Jiangsu Higher Education Institutions; National Natural Science
   Foundation of China, Grant/Award Number: 31801545; Open project of China
   Canada food nutrition and health Joint Laboratory, Grant/Award Number:
   ZJ-2020-07
CR Abdel-Mobdy AE, 2021, FOOD SCI BIOTECHNOL, V30, P107, DOI 10.1007/s10068-020-00842-3
   Amer Diabet Assoc, 2014, DIABETES CARE, V37, pS81, DOI [10.2337/dc13-S067, 10.2337/dc14-S081, 10.2337/dc13-S011, 10.2337/dc10-S062, 10.2337/dc10-S011, 10.2337/dc11-S062, 10.2337/dc12-s064, 10.2337/dc11-S011]
   American Diabetes Association, 2011, Diabetes Care, V34 Suppl 1, pS4, DOI 10.2337/dc11-S004
   Betteridge DJ, 2000, METABOLISM, V49, P3, DOI 10.1016/S0026-0495(00)80077-3
   Bonadonna RC, 2017, DIABETES-METAB RES, V33, DOI 10.1002/dmrr.2897
   Bozcaarmutlu A, 2022, DRUG CHEM TOXICOL, V45, P990, DOI 10.1080/01480545.2020.1802475
   Buse JB, 2011, NAT REV ENDOCRINOL, V7, P67, DOI 10.1038/nrendo.2010.230
   Chatterjee S, 2017, LANCET, V389, P2239, DOI 10.1016/S0140-6736(17)30058-2
   Chen D, 2019, J FUNCT FOODS, V61, DOI 10.1016/j.jff.2019.103470
   Chen P, 2014, J FUNCT FOODS, V10, P318, DOI 10.1016/j.jff.2014.06.014
   Dhuique-Mayer C, 2020, FOOD FUNCT, V11, P9263, DOI 10.1039/d0fo02430a
   Ding Y, 2019, FOOD FUNCT, V10, P7576, DOI 10.1039/c9fo01575b
   DiSogra Robert M., 2019, Seminars in Hearing, V40, P315, DOI 10.1055/s-0039-1697645
   Forsman JJ, 2011, CHEM REV, V111, P3334, DOI 10.1021/cr1002563
   Franks PW, 2016, SCIENCE, V354, P69, DOI 10.1126/science.aaf5094
   Giaccari A, 2021, DIABETES CARE, V44, P647, DOI 10.2337/dc20-1964
   Gu CY, 2016, ONCOTARGET, V7, P48941, DOI 10.18632/oncotarget.10597
   Hao L, 2015, FOOD NUTR RES, V59, DOI 10.3402/fnr.v59.28886
   Herman WH, 2017, DIABETES MELLITUS DE, P1, DOI DOI 10.1007/978-3-319-41559-8_1
   Hu B., 2018, WORLD J ENG TECHNOL, V06, P24, DOI [10.4236/wjet.2018.63B004, DOI 10.4236/WJET.2018.63B004]
   Jin D, 2020, FOOD FUNCT, V11, P10617, DOI [10.1039/d0fo01275k, 10.1039/D0FO01275K]
   Kanikarla-Marie P, 2015, CELL PHYSIOL BIOCHEM, V37, P2160, DOI 10.1159/000438573
   Kanoski SE, 2011, PHYSIOL BEHAV, V103, P59, DOI 10.1016/j.physbeh.2010.12.003
   Khat-udomkiri N, 2020, FOOD SCI NUTR, V8, P428, DOI 10.1002/fsn3.1327
   Krog-Mikkelsen I, 2011, AM J CLIN NUTR, V94, P472, DOI 10.3945/ajcn.111.014225
   Li XF, 2020, J DAIRY SCI, V103, P7719, DOI 10.3168/jds.2019-17757
   Liu TY, 2015, CLIN SCI, V129, P839, DOI 10.1042/CS20150009
   Liu Xingrong, 2013, Wei Sheng Yan Jiu, V42, P295
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Muskiet MHA, 2020, DIABETES CARE, V43, P2889, DOI 10.2337/dc20-0902
   Obaroakpo JU, 2020, FOOD FUNCT, V11, P8354, DOI 10.1039/d0fo01575j
   Osaki S, 2001, J NUTR, V131, P796, DOI 10.1093/jn/131.3.796
   Pan YX, 2017, CARBOHYD POLYM, V164, P370, DOI 10.1016/j.carbpol.2017.01.092
   Rahier J, 2008, DIABETES OBES METAB, V10, P32, DOI 10.1111/j.1463-1326.2008.00969.x
   Razieh Yazdanparast, 2005, Iranian Biomedical Journal, V9, P81
   Rehfeld JF, 2019, SCAND J GASTROENTERO, V54, P1448, DOI 10.1080/00365521.2019.1690673
   Rosenson RS, 2005, DIABETES RES CLIN PR, V68, pS36, DOI 10.1016/j.diabres.2005.03.013
   Seri K, 1996, METABOLISM, V45, P1368, DOI 10.1016/S0026-0495(96)90117-1
   Shaw JE, 2010, DIABETES RES CLIN PR, V87, P4, DOI 10.1016/j.diabres.2009.10.007
   Shibanuma K, 2011, EUR J NUTR, V50, P447, DOI 10.1007/s00394-010-0154-3
   Song YB, 2012, FOOD CHEM, V134, P189, DOI 10.1016/j.foodchem.2012.02.091
   Ueno H, 2015, DIABETES THER, V6, P187, DOI 10.1007/s13300-015-0113-3
   Wang G, 2017, FOOD FUNCT, V8, P3155, DOI 10.1039/c7fo00593h
   Wang Xin, 2012, Wei Sheng Yan Jiu, V41, P260
   Wang Y, 2021, FOOD FUNCT, V12, P1745, DOI [10.1039/D0FO02163F, 10.1039/d0fo02163f]
   Winkler G, 2003, EUR J ENDOCRINOL, V149, P129, DOI 10.1530/eje.0.1490129
   Wu CY, 2020, FOOD FUNCT, V11, P9740, DOI [10.1039/d0fo02434a, 10.1039/D0FO02434A]
   Zhang MX, 2017, FOOD FUNCT, V8, P3696, DOI [10.1039/c7fo00712d, 10.1039/C7FO00712D]
   Zhao L, 2019, NUTRIENTS, V11, DOI 10.3390/nu11123054
   Zou YC, 2020, FOOD FUNCT, V11, P2406, DOI 10.1039/c9fo01524h
NR 50
TC 4
Z9 4
U1 11
U2 39
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0145-8884
EI 1745-4514
J9 J FOOD BIOCHEM
JI J. Food Biochem.
PD DEC
PY 2021
VL 45
IS 12
AR e13991
DI 10.1111/jfbc.13991
EA NOV 2021
PG 14
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA XL5YY
UT WOS:000718204300001
PM 34778991
OA gold
DA 2023-06-08
ER

PT J
AU Wei, NA
   Lu, JM
   Lin, ZB
   Wang, XY
   Cai, MM
   Jiang, SY
   Chen, XY
   Zhu, SL
   Zhang, D
   Cui, L
AF Wei, Nana
   Lu, Jinmiao
   Lin, Zhibing
   Wang, Xiaoyu
   Cai, Mengmeng
   Jiang, Shengyao
   Chen, Xiaoyu
   Zhu, Shilan
   Zhang, Dong
   Cui, Li
TI Systemic Evaluation of the Effect of Diabetes Mellitus on Breast Cancer
   in a Mouse Model
SO FRONTIERS IN ONCOLOGY
LA English
DT Article
DE diabetes mellitus; breast cancer; gut microbiome; tumor
   microenvironment; amino acid metabolism
ID INTESTINAL MICROBIOTA; NECK-CANCER; RISK; GUT; TRANSPLANTATION;
   METFORMIN; CELLS; EPIDEMIOLOGY; METABOLISM; CHEMOKINES
AB Breast cancer complicated with diabetes mellitus (DM) is a common disease. To evaluate the effect of preexisting DM on breast cancer progression without drug interference, we used a streptozotocin (STZ)-induced type 2 diabetes mellitus BALB/c mouse model. We found that 4T1 breast cancer complicated with DM decreased the mouse survival time compared with 4T1-bearing mice. The diversity of gut microbiome was affected by DM. The infiltration of mucosal-associated invariant T cell (MAIT), CD8+ T cell, and CD4+ T cell in the tumor was significantly decreased in the DM-4T1 group compared with the 4T1 group. The transcriptome data of tumor tissues indicated that the expressions of inflammatory C-C chemokine- and metabolism-related genes were greatly changed. The abnormal expression of these genes may be related with the decreased T-cell infiltration in DM-4T1. In conclusion, the gut microbiome and tumor microenvironment of diabetic breast cancer patients have unique features. The effect of diabetes on breast cancer should be considered in the treatment for diabetic breast cancer patients.
C1 [Lin, Zhibing; Wang, Xiaoyu; Jiang, Shengyao; Zhang, Dong; Cui, Li] Shanghai Jiao Tong Univ, Sch Agr & Biol, Shanghai Key Lab Vet Biotechnol, Shanghai, Peoples R China.
   [Wei, Nana] EastChina Normal Univ, Key Lab Adolescent Hlth Assessment & Exercise Inte, Minist Educ, Shanghai, Peoples R China.
   [Lu, Jinmiao; Cai, Mengmeng; Chen, Xiaoyu; Zhu, Shilan] Chinese Acad Agr Sci, Shanghai Vet Res Inst, Lab Qual & Safety Risk Assessment Anim Products Bi, Key Lab Anim Parasitol,Minist Agr,Minist Educ, Shanghai, Peoples R China.
C3 Shanghai Jiao Tong University; Chinese Academy of Agricultural Sciences;
   Shanghai Veterinary Research Institute, CAAS; Ministry of Agriculture &
   Rural Affairs
RP Cui, L (通讯作者)，Shanghai Jiao Tong Univ, Sch Agr & Biol, Shanghai Key Lab Vet Biotechnol, Shanghai, Peoples R China.
EM lcui@sjtu.edu.cn
CR Ashton TM, 2018, CLIN CANCER RES, V24, P2482, DOI 10.1158/1078-0432.CCR-17-3070
   Bae Jong Myon, 2020, J Menopausal Med, V26, P29, DOI 10.6118/jmm.19014
   Baglia ML, 2019, CANCER RES TREAT, V51, P538, DOI 10.4143/crt.2017.591
   Bakhshinejad B, 2017, VIRUS RES, V240, P47, DOI 10.1016/j.virusres.2017.07.013
   Bonovas S, 2004, DIABETOLOGIA, V47, P1071, DOI 10.1007/s00125-004-1415-6
   Bradley CA, 2015, NAT REV ENDOCRINOL, V13, DOI 10.1038/nrendo.2017.37
   Carstensen B, 2014, CURR DIABETES REP, V14, DOI 10.1007/s11892-014-0535-8
   Cho H, 2016, J PATHOL TRANSL MED, V50, P45, DOI 10.4132/jptm.2015.10.16
   Corbett AJ, 2014, NATURE, V509, P361, DOI 10.1038/nature13160
   Coughlin SS, 2004, AM J EPIDEMIOL, V159, P1160, DOI 10.1093/aje/kwh161
   Coyle C, 2016, ANN ONCOL, V27, P2184, DOI 10.1093/annonc/mdw410
   Dai ZW, 2018, MICROBIOME, V6, DOI 10.1186/s40168-018-0451-2
   Deeds MC, 2011, LAB ANIM-UK, V45, P131, DOI 10.1258/la.2010.010090
   Gagniere J, 2016, WORLD J GASTROENTERO, V22, P501, DOI 10.3748/wjg.v22.i2.501
   Gopalakrishnan V, 2018, CANCER CELL, V33, P570, DOI 10.1016/j.ccell.2018.03.015
   Griffith JW, 2014, ANNU REV IMMUNOL, V32, P659, DOI 10.1146/annurev-immunol-032713-120145
   Guerrero-Preston RE, 2017, CANCER RES, V77, DOI 10.1158/1538-7445.AM2017-1018
   Hamm A, 2008, BMC CANCER, V8, DOI 10.1186/1471-2407-8-25
   Herder C, 2006, DIABETOLOGIA, V49, P921, DOI 10.1007/s00125-006-0190-y
   Jin L, 2017, ONCOTARGET, V8, P5135, DOI 10.18632/oncotarget.14095
   Kasper JS, 2006, CANCER EPIDEM BIOMAR, V15, P2056, DOI 10.1158/1055-9965.EPI-06-0410
   Korostin D, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0230301
   Kozich JJ, 2013, APPL ENVIRON MICROB, V79, P5112, DOI 10.1128/AEM.01043-13
   Larsson SC, 2006, DIABETOLOGIA, V49, P2819, DOI 10.1007/s00125-006-0468-0
   Lawrence WR, 2020, CANCER EPIDEMIOL, V66, DOI 10.1016/j.canep.2020.101710
   Lee EK, 2021, DIABETES RES CLIN PR, V174, DOI 10.1016/j.diabres.2021.108751
   Legoux F, 2019, SCIENCE, V366, P494, DOI 10.1126/science.aaw2719
   Li XH, 2018, PATHOL ONCOL RES, V24, P663, DOI 10.1007/s12253-017-0285-4
   Lim SJ, 2021, ADV EXP MED BIOL, V1302, P91, DOI 10.1007/978-3-030-62658-7_7
   Lipscombe LL, 2008, BREAST CANCER RES TR, V109, P389, DOI 10.1007/s10549-007-9654-0
   Nakamura N, 2019, BMC CANCER, V19, DOI 10.1186/s12885-019-5825-8
   Needell JC, 2016, CURR DIABETES REP, V16, DOI 10.1007/s11892-016-0781-z
   Ohkuma T, 2018, DIABETOLOGIA, V61, P2140, DOI 10.1007/s00125-018-4664-5
   Omana-Molina M, 2017, EXP PARASITOL, V183, P150, DOI 10.1016/j.exppara.2017.09.001
   Paun A, 2016, J AUTOIMMUN, V71, P10, DOI 10.1016/j.jaut.2016.02.004
   Pernicova I, 2014, NAT REV ENDOCRINOL, V10, P143, DOI 10.1038/nrendo.2013.256
   Qi JY, 2019, J DIABETES, V11, P878, DOI 10.1111/1753-0407.12926
   Riquelme E, 2019, CELL, V178, P795, DOI 10.1016/j.cell.2019.07.008
   Risch HA, 2019, JNCI-J NATL CANCER I, V111, P1, DOI 10.1093/jnci/djy093
   Sell H, 2009, P NUTR SOC, V68, P378, DOI 10.1017/S0029665109990218
   Shonka NA, 2006, MED ONCOL, V23, P515, DOI 10.1385/MO:23:4:515
   Sira Mostafa M, 2014, Hepat Res Treat, V2014, P307942, DOI 10.1155/2014/307942
   Stott-Miller M, 2012, CANCER EPIDEM BIOMAR, V21, P294, DOI 10.1158/1055-9965.EPI-11-0590
   Sun YY, 2021, CLIN CHIM ACTA, V523, P365, DOI 10.1016/j.cca.2021.10.022
   Tilg H, 2018, CANCER CELL, V33, P954, DOI 10.1016/j.ccell.2018.03.004
   Udayappan SD, 2014, CLIN EXP IMMUNOL, V177, P24, DOI 10.1111/cei.12293
   Vandeputte D, 2017, NATURE, V551, P507, DOI 10.1038/nature24460
   Wang CY, 2020, J DIABETES INVEST, V11, P490, DOI 10.1111/jdi.13112
   Wang YB, 2020, EUR J CANCER PREV, V29, P42, DOI 10.1097/CEJ.0000000000000514
   Whitaker-Menezes D, 2011, CELL CYCLE, V10, P4047, DOI 10.4161/cc.10.23.18151
   Xu MQ, 2015, WORLD J GASTROENTERO, V21, P102, DOI 10.3748/wjg.v21.i1.102
   Yan JM, 2020, CANCER DISCOV, V10, P124, DOI 10.1158/2159-8290.CD-19-0569
   Zacksenhaus E, 2017, TRENDS CANCER, V3, P768, DOI 10.1016/j.trecan.2017.09.002
   Zhou Y, 2018, ONCOL LETT, V16, P4303, DOI 10.3892/ol.2018.9197
   Zitvogel L, 2016, CELL, V165, P276, DOI 10.1016/j.cell.2016.03.001
NR 55
TC 1
Z9 1
U1 2
U2 7
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2234-943X
J9 FRONT ONCOL
JI Front. Oncol.
PD APR 29
PY 2022
VL 12
AR 829798
DI 10.3389/fonc.2022.829798
PG 10
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 1G7KA
UT WOS:000796021700001
PM 35578660
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Wang, WX
   Sang, SM
AF Wang, Weixin
   Sang, Shengmin
TI Biotransformation of Barley Phenolamide by Mice and the Human Gut
   Microbiota and Quantitative Analysis of the Major Metabolites in Mice
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Article
DE barley; gut microbiota; metabolites; metformin; p-coumaroylagmatine
ID INSULIN SENSITIVITY; ARGININE
AB Scope This study investigates the metabolism of p-coumaroylagmatine (pCAA), one of the phenolamides in barley, in mice, and by human gut microbiota, and measures the concentrations of its main metabolites in mice. Methods and results Nine major metabolites are identified from fecal and urinary samples collected from pCAA treated mice via analysis of their LC chromatograms and tandem mass spectra compared to the commercial and synthesized standards. These nine metabolites are generated through four different biotransformation pathways: double bond reduction, amide bond hydrolyzation, cleavage of guanidine, and oxidation of guanidine. Furthermore, interindividual differences in the formation of dihydro-pCAA (M3), high and low metabolizers, are observed in human in vitro intestinal microbial conversion. Moreover, significant amount of pCAA is detected in mice (29.33 +/- 1.58 mu mol g(-1) in feces and 2020.44 +/- 130.07 mu M in urine), and the concentrations of agmatine (M1) are increased to 177.6 times and 3.2 times in mouse feces and urine, respectively. Conclusion This study demonstrates that pCAA is metabolized in mice and by human gut microbiota to generate potential bioactive metabolites through four major metabolic pathways. pCAA and its metabolites have the potential to be used as the exposure biomarkers to reflect the intake of whole grain barley.
C1 [Wang, Weixin; Sang, Shengmin] North Carolina Agr & Tech State Univ, Ctr Excellence Postharvest Technol, Lab Funct Foods & Human Hlth, North Carolina Res Campus,500 Laureate Way, Kannapolis, NC 28081 USA.
C3 University of North Carolina; North Carolina A&T State University
RP Sang, SM (通讯作者)，North Carolina Agr & Tech State Univ, Ctr Excellence Postharvest Technol, Lab Funct Foods & Human Hlth, North Carolina Res Campus,500 Laureate Way, Kannapolis, NC 28081 USA.
EM ssang@ncat.edu
RI Sang, Shengmin/AFK-9982-2022
OI Sang, Shengmin/0000-0002-5005-3616
FU United States Department of Agriculture (USDA) National Institute of
   Food and Agriculture (NIFA) [2018-67001-28265]
FX This work was supported by funding from The United States Department of
   Agriculture (USDA) National Institute of Food and Agriculture (NIFA)
   grant 2018-67001-28265 to S.S.
CR Barykina OV, 2010, ORG LETT, V12, P2664, DOI 10.1021/ol100896n
   Chen HD, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0051001
   Choi SW, 2007, J AGR FOOD CHEM, V55, P3920, DOI 10.1021/jf0635154
   Deusch S, 2019, MICROORGANISMS, V7, DOI 10.3390/microorganisms7050117
   Dong XK, 2015, MOL PLANT, V8, P111, DOI 10.1016/j.molp.2014.11.003
   Franke T, 2018, MOL MICROBIOL, V109, P528, DOI 10.1111/mmi.14058
   Gorzolka K, 2014, PLANTA, V239, P1321, DOI 10.1007/s00425-014-2061-y
   Idehen E., 2020, J FOOD BIOACT, V12, P76
   Idehen E, 2017, J FOOD DRUG ANAL, V25, P148, DOI 10.1016/j.jfda.2016.08.002
   Kang S, 2017, NEUROPHARMACOLOGY, V113, P467, DOI 10.1016/j.neuropharm.2016.10.029
   Khalaf D, 2019, NUTRIENTS, V11, DOI 10.3390/nu11071679
   Koistinen VM, 2020, NPJ SCI FOOD, V4, DOI 10.1038/s41538-020-00081-0
   Kotagale N, 2021, EUR J PHARMACOL, V907, DOI 10.1016/j.ejphar.2021.174255
   Kovatcheva-Datchary P, 2015, CELL METAB, V22, P971, DOI 10.1016/j.cmet.2015.10.001
   Liu ZH, 2021, MOL NUTR FOOD RES, V65, DOI 10.1002/mnfr.202100454
   Morris SM, 2016, J NUTR, V146, P2579, DOI 10.3945/jn.115.226621
   Nair Anroop B, 2016, J Basic Clin Pharm, V7, P27, DOI 10.4103/0976-0105.177703
   Nilsson AC, 2015, BRIT J NUTR, V114, P899, DOI 10.1017/S0007114515002524
   Omer M.M.A., 2019, JFCN, V5, P1, DOI [10.17756/jfcn.2019-065, DOI 10.17756/JFCN.2019-065]
   Pryor R, 2019, CELL, V178, P1299, DOI 10.1016/j.cell.2019.08.003
   Shepherd RM, 1996, BRIT J PHARMACOL, V119, P911, DOI 10.1111/j.1476-5381.1996.tb15759.x
   STOESSL A., 1965, PHYTOCHEMISTRY, V4, P973, DOI 10.1016/S0031-9422(00)86277-9
   Stuehr DJ, 2004, J NUTR, V134, p2748S, DOI 10.1093/jn/134.10.2748S
   Su CH, 2009, NEUROSCI LETT, V457, P125, DOI 10.1016/j.neulet.2009.03.093
   Tosh SM, 2020, NUTR REV, V78, P13, DOI 10.1093/nutrit/nuz085
   Ube N, 2019, PHYTOCHEMISTRY, V167, DOI 10.1016/j.phytochem.2019.112098
   Wang P, 2015, J NUTR, V145, P239, DOI 10.3945/jn.114.206508
   Wen WW, 2014, NAT COMMUN, V5, DOI 10.1038/ncomms4438
   Yamane M, 2021, PHYTOCHEMISTRY, V189, DOI 10.1016/j.phytochem.2021.112825
   Zhang SW, 2021, MOL NUTR FOOD RES, V65, DOI 10.1002/mnfr.202000887
NR 30
TC 1
Z9 1
U1 3
U2 18
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD JUL
PY 2022
VL 66
IS 13
AR 2200134
DI 10.1002/mnfr.202200134
EA MAY 2022
PG 11
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 2Q1CE
UT WOS:000796752400001
PM 35532207
DA 2023-06-08
ER

PT J
AU Cabreiro, F
   Gems, D
AF Cabreiro, Filipe
   Gems, David
TI Worms need microbes too: microbiota, health and aging in Caenorhabditis
   elegans
SO EMBO MOLECULAR MEDICINE
LA English
DT Article
DE aging; C; elegans; metformin; microbiota; type-2 diabetes
ID LIFE-SPAN EXTENSION; TYPE-2 DIABETES-MELLITUS; C.-ELEGANS; GUT
   MICROBIOTA; DIETARY RESTRICTION; CALORIC RESTRICTION; GERM-FREE;
   BACTERIAL PROLIFERATION; STRESS RESISTANCE; VIRULENCE FACTORS
AB Many animal species live in close association with commensal and symbiotic microbes (microbiota). Recent studies have revealed that the status of gastrointestinal tract microbiota can influence nutrition-related syndromes such as obesity and type-2 diabetes, and perhaps aging. These morbidities have a profound impact in terms of individual suffering, and are an increasing economic burden to modern societies. Several theories have been proposed for the influence of microbiota on host metabolism, but these largely remain to be proven. In this article we discuss how microbiota may be manipulated (via pharmacology, diet, or gene manipulation) in order to alter metabolism, immunity, health and aging in the host. The nematode Caenorhabditis elegans in combination with one microbial species is an excellent, defined model system to investigate the mechanisms of host-microbiota interactions, particularly given the combined power of worm and microbial genetics. We also discuss the multifaceted nature of the worm-microbe relationship, which likely encompasses predation, commensalism, pathogenicity and necromeny.
C1 [Cabreiro, Filipe] UCL, Inst Hlth Ageing, London, England.
   UCL, Res Dept Genet Evolut & Environm, London, England.
C3 University of London; University College London; University of London;
   University College London
RP Cabreiro, F (通讯作者)，UCL, Inst Hlth Ageing, London, England.
EM f.cabreiro@ucl.ac.uk
OI Gems, David/0000-0002-6653-4676; Cabreiro, Filipe/0000-0002-3696-4843
FU EU [FP7-259679 IDEAL]; Wellcome Trust
FX We thank Helena Cocheme for useful help with preparation of the figures
   and Alexandre Benedetto, Heather Elding and Matt Piper for comments on
   the manuscript. F. C. and D. G. acknowledge funding from the EU
   (FP7-259679 IDEAL), and the Wellcome Trust (Strategic Award).
CR Anisimov VN, 2008, CELL CYCLE, V7, P2769, DOI 10.4161/cc.7.17.6625
   Baeriswyl S, 2010, BIOGERONTOLOGY, V11, P53, DOI 10.1007/s10522-009-9228-0
   Bailey CJ, 2008, DIABETOLOGIA, V51, P1552, DOI 10.1007/s00125-008-1053-5
   Bishop NA, 2007, NATURE, V447, P545, DOI 10.1038/nature05904
   BRENNER S, 1974, GENETICS, V77, P71
   Brooks KK, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0007545
   Browning DF, 2013, MOL MICROBIOL, V87, P939, DOI 10.1111/mmi.12144
   Bumbarger DJ, 2013, CELL, V152, P109, DOI 10.1016/j.cell.2012.12.013
   Bytzer P, 2001, ALIMENT PHARM THER, V15, P137, DOI 10.1046/j.1365-2036.2001.00896.x
   Cabreiro F, 2013, CELL, V153, P228, DOI 10.1016/j.cell.2013.02.035
   Cani PD, 2009, CURR PHARM DESIGN, V15, P1546, DOI 10.2174/138161209788168164
   Cho I, 2012, NAT REV GENET, V13, P260, DOI 10.1038/nrg3182
   Claesson MJ, 2012, NATURE, V488, P178, DOI 10.1038/nature11319
   Clemente JC, 2012, CELL, V148, P1258, DOI 10.1016/j.cell.2012.01.035
   Collison M, 2012, BRIEF BIOINFORM, V13, P751, DOI 10.1093/bib/bbs002
   Dowling RJO, 2011, BMC MED, V9, DOI 10.1186/1741-7015-9-33
   Ewbank JJ, 2011, DIS MODEL MECH, V4, P300, DOI 10.1242/dmm.006684
   Felix MA, 2012, BMC BIOL, V10, DOI 10.1186/1741-7007-10-59
   Fraune S, 2010, BIOESSAYS, V32, P571, DOI 10.1002/bies.200900192
   Garigan D, 2002, GENETICS, V161, P1101
   Garsin DA, 2001, P NATL ACAD SCI USA, V98, P10892, DOI 10.1073/pnas.191378698
   Garsin DA, 2003, SCIENCE, V300, P1921, DOI 10.1126/science.1080147
   Gems D, 2000, GENETICS, V154, P1597
   Gomez F, 2012, BMC MICROBIOL, V12, DOI 10.1186/1471-2180-12-300
   Greer EL, 2007, CURR BIOL, V17, P1646, DOI 10.1016/j.cub.2007.08.047
   Greer EL, 2009, AGING CELL, V8, P113, DOI 10.1111/j.1474-9726.2009.00459.x
   Greiner T, 2011, TRENDS ENDOCRIN MET, V22, P117, DOI 10.1016/j.tem.2011.01.002
   Gusarov I, 2013, CELL, V152, P818, DOI 10.1016/j.cell.2012.12.043
   Haiser HJ, 2012, SCIENCE, V336, P1253, DOI 10.1126/science.1224396
   HOSONO R, 1989, EXP GERONTOL, V24, P251, DOI 10.1016/0531-5565(89)90016-8
   Houthoofd K, 2002, EXP GERONTOL, V37, P1371, DOI 10.1016/S0531-5565(02)00173-0
   Ikeda T, 2007, APPL ENVIRON MICROB, V73, P6404, DOI 10.1128/AEM.00704-07
   Jones KT, 2009, DIS MODEL MECH, V2, P224, DOI 10.1242/dmm.001933
   Kaddurah-Daouk R, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0025482
   Kaeberlein TL, 2006, AGING CELL, V5, P487, DOI 10.1111/j.1474-9726.2006.00238.x
   Kau AL, 2011, NATURE, V474, P327, DOI 10.1038/nature10213
   Kenyon CJ, 2010, NATURE, V464, P504, DOI 10.1038/nature08980
   Khalif IL, 2005, DIGEST LIVER DIS, V37, P838, DOI 10.1016/j.dld.2005.06.008
   Kim Y, 2012, INFECT IMMUN, V80, P2500, DOI 10.1128/IAI.06350-11
   KLASS MR, 1977, MECH AGEING DEV, V6, P413, DOI 10.1016/0047-6374(77)90043-4
   Komura T, 2013, BIOGERONTOLOGY, V14, P73, DOI 10.1007/s10522-012-9411-6
   Kootte RS, 2012, DIABETES OBES METAB, V14, P112, DOI 10.1111/j.1463-1326.2011.01483.x
   Kurz CL, 2003, EMBO J, V22, P1451, DOI 10.1093/emboj/cdg159
   Laaberki MH, 2008, J BACTERIOL, V190, P6197, DOI 10.1128/JB.00623-08
   Lakowski B, 1998, P NATL ACAD SCI USA, V95, P13091, DOI 10.1073/pnas.95.22.13091
   Lee H, 2012, NAT NEUROSCI, V15, P107, DOI 10.1038/nn.2975
   Lee J, 2011, INT J FOOD MICROBIOL, V148, P80, DOI 10.1016/j.ijfoodmicro.2011.05.003
   Lenaerts I, 2008, J GERONTOL A-BIOL, V63, P242, DOI 10.1093/gerona/63.3.242
   Leroy M, 2012, BMC EVOL BIOL, V12, DOI 10.1186/1471-2148-12-187
   Lin J, 2011, DIS MODEL MECH, V4, P447, DOI 10.1242/dmm.007252
   Liu HJ, 2012, NAT COMMUN, V3, DOI 10.1038/ncomms2071
   MacNeil LT, 2013, CELL, V153, P240, DOI 10.1016/j.cell.2013.02.049
   Maier W, 2010, PLOS BIOL, V8, DOI 10.1371/journal.pbio.1000376
   Mair W, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0004535
   Masoro EJ, 2005, MECH AGEING DEV, V126, P913, DOI 10.1016/j.mad.2005.03.012
   Maurice CF, 2013, CELL, V152, P39, DOI 10.1016/j.cell.2012.10.052
   McGee MD, 2011, AGING CELL, V10, P699, DOI 10.1111/j.1474-9726.2011.00713.x
   Metchnikoff E., 1910, ANN I PASTEUR PARIS, V24, P753
   Moal VLL, 2006, CLIN MICROBIOL REV, V19, P315, DOI 10.1128/CMR.19.2.315-337.2006
   Muegge BD, 2011, SCIENCE, V332, P970, DOI 10.1126/science.1198719
   Nicholson JK, 2012, SCIENCE, V336, P1262, DOI 10.1126/science.1223813
   O'Hara AM, 2006, EMBO REP, V7, P688, DOI 10.1038/sj.embor.7400731
   Onken B, 2010, PLOS ONE, V24, P753
   Ottaviani E, 2011, BIOGERONTOLOGY, V12, P599, DOI 10.1007/s10522-011-9352-5
   Pierotti MA, 2013, ONCOGENE, V32, P1475, DOI 10.1038/onc.2012.181
   Portal-Celhay C, 2013, FASEB J, V27, P760, DOI 10.1096/fj.12-218420
   Portal-Celhay C, 2012, BMC MICROBIOL, V12, DOI 10.1186/1471-2180-12-49
   Portal-Celhay C, 2012, INFECT IMMUN, V80, P1288, DOI 10.1128/IAI.05522-11
   Proctor WR, 2008, DRUG METAB DISPOS, V36, P1650, DOI 10.1124/dmd.107.020180
   Pukkila-Worley R, 2012, CURR OPIN IMMUNOL, V24, P3, DOI 10.1016/j.coi.2011.10.004
   Pyra KA, 2012, J NUTR, V142, P213, DOI 10.3945/jn.111.147132
   Rae R, 2012, INT J PARASITOL, V42, P747, DOI 10.1016/j.ijpara.2012.05.005
   Rauch M, 2012, CURR OPIN BIOTECH, V23, P192, DOI 10.1016/j.copbio.2011.11.004
   Rawls JF, 2004, P NATL ACAD SCI USA, V101, P4596, DOI 10.1073/pnas.0400706101
   Reinke SN, 2010, MOL GENET METAB, V100, P274, DOI 10.1016/j.ymgme.2010.03.013
   Rera M, 2013, AGEING RES REV, V12, P436, DOI 10.1016/j.arr.2012.05.003
   Rosenberg E, 2011, BIRTH DEFECTS RES C, V93, P56, DOI 10.1002/bdrc.20196
   Sahin M, 2007, J DIABETES COMPLICAT, V21, P118, DOI 10.1016/j.jdiacomp.2005.10.005
   Saiki R, 2008, AGING CELL, V7, P291, DOI 10.1111/j.1474-9726.2008.00378.x
   SAVAGE DC, 1977, ANNU REV MICROBIOL, V31, P107, DOI 10.1146/annurev.mi.31.100177.000543
   Schluter J, 2012, PLOS BIOL, V10, DOI 10.1371/journal.pbio.1001424
   Schulenburg H, 2004, IMMUNOL REV, V198, P36, DOI 10.1111/j.0105-2896.2004.0125.x
   Scott KP, 2011, BIOCHEM SOC T, V39, P1073, DOI 10.1042/BST0391073
   Shimizu K, 1998, EXP ANIM TOKYO, V47, P151, DOI 10.1538/expanim.47.151
   Shin SC, 2011, SCIENCE, V334, P670, DOI 10.1126/science.1212782
   Sifri CD, 2005, TRENDS MICROBIOL, V13, P119, DOI 10.1016/j.tim.2005.01.003
   Smith ED, 2008, BMC DEV BIOL, V8, DOI 10.1186/1471-213X-8-49
   SNYDER DL, 1990, J GERONTOL, V45, pB52, DOI 10.1093/geronj/45.2.B52
   TAZUME S, 1991, EXP ANIM TOKYO, V40, P517, DOI 10.1538/expanim1978.40.4_517
   Troemel ER, 2008, PLOS BIOL, V6, P2736, DOI 10.1371/journal.pbio.0060309
   Ubeda C, 2012, TRENDS IMMUNOL, V33, P459, DOI 10.1016/j.it.2012.05.003
   Virk B, 2012, BMC BIOL, V10, DOI 10.1186/1741-7007-10-67
   von Mutius E, 2000, CLIN EXP ALLERGY, V30, P1230
   Walker AK, 2011, CELL, V147, P840, DOI 10.1016/j.cell.2011.09.045
   Walker G, 2005, MECH AGEING DEV, V126, P929, DOI 10.1016/j.mad.2005.03.014
   Wang CY, 2011, J FOOD PROTECT, V74, P86, DOI 10.4315/0362-028X.JFP-10-155
   Wang YL, 2007, J PROTEOME RES, V6, P1846, DOI 10.1021/pr060685n
   Wikoff WR, 2009, P NATL ACAD SCI USA, V106, P3698, DOI 10.1073/pnas.0812874106
   Youngman MJ, 2011, PLOS GENET, V7, DOI 10.1371/journal.pgen.1002082
NR 99
TC 127
Z9 131
U1 2
U2 103
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1757-4676
EI 1757-4684
J9 EMBO MOL MED
JI EMBO Mol. Med.
PD SEP
PY 2013
VL 5
IS 9
BP 1300
EP 1310
DI 10.1002/emmm.201100972
PG 11
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 209TN
UT WOS:000323783000003
PM 23913848
OA Green Published
DA 2023-06-08
ER

PT J
AU Zhang, XY
   Fang, ZW
   Zhang, CF
   Xia, HH
   Jie, ZY
   Han, XY
   Chen, YL
   Ji, LN
AF Zhang, Xiuying
   Fang, Zhiwei
   Zhang, Chunfang
   Xia, Huihua
   Jie, Zhuye
   Han, Xueyao
   Chen, Yingli
   Ji, Linong
TI Effects of Acarbose on the Gut Microbiota of Prediabetic Patients: A
   Randomized, Double-blind, Controlled Crossover Trial
SO DIABETES THERAPY
LA English
DT Article
DE Acarbose; Cardiovascular disease; Gut microflora; Prediabetes; Type 2
   diabetes
ID IMPAIRED GLUCOSE-TOLERANCE; LIFE-STYLE INTERVENTION; DIET-INDUCED
   OBESITY; DIALISTER-PNEUMOSINTES; SP-NOV.; LACTOBACILLUS-CASEI;
   METFORMIN; INFLAMMATION; PREVENTION; SIGNATURES
AB Introduction: The alpha-glucosidase inhibitor acarbose is an efficacious medicine for the treatment and prevention of type 2 diabetes mellitus (T2DM). However, the response of gut microbiota to acarbose is important, as the microbiota may have a critical role in the development of metabolic diseases, and acarbose is metabolized exclusively within the gastrointestinal tract. We explored the changes in the proportion and diversity of gut microbiota before and after treatment with acarbose in patients with prediabetes.
   Methods: We designed a randomized, double-blind, controlled crossover trial in which 52 Chinese patients with prediabetes by an oral glucose tolerance test (OGTT) with a BMI of 18-35 kg/m(2) were randomly allocated to treatment with acarbose or placebo. Gut microbiota characterizations were determined with16SrDNA-basedhigh-throughput sequencing.
   Results: Of the 52 participants who entered the study, 40 (76.9%) completed the protocol. On the basis of the operational taxonomic unit (OTU) profiles, a total of 107 OTUs were significantly altered after acarbose treatment, with 76 (71%) assigned to the order of Clostridiales. Ruminococcaceae (15 OTUs) and Lachnospiraceae (22 OTUs) decreased in response to acarbose, and 48 OTUs increased by 12.8-fold, including Lactobacillaceae (8 of 9 belonging to Lactobacillus), Ruminococcaceae (6 of 11 belonging to Faecalibacterium), and Veillonellaceae (8 of 15 belonging to Dialister). At genera level, five flourished after treatment with acarbose, including Lactobacillus and Dialister, while Butyricicoccus, Phascolarctobacterium, and Ruminococcus were inhibited.
   Conclusion: This study suggests that the benefits of acarbose for T2DM may correlate with the selective modulation of the gut microbiota.
C1 [Zhang, Xiuying; Han, Xueyao; Chen, Yingli; Ji, Linong] Peking Univ, Peoples Hosp, Diabet Ctr, Dept Endocrinol & Metab, Beijing 100044, Peoples R China.
   [Fang, Zhiwei] Jianghan Univ, Inst Syst Biol, Wuhan 430056, Peoples R China.
   [Zhang, Chunfang] Peking Univ, Peoples Hosp, Dept Clin Epidemiol, Beijing 100044, Peoples R China.
   [Xia, Huihua; Jie, Zhuye] BGI Shenzhen, Shenzhen 518083, Peoples R China.
C3 Peking University; Jianghan University; Peking University; Beijing
   Genomics Institute (BGI)
RP Ji, LN (通讯作者)，Peking Univ, Peoples Hosp, Diabet Ctr, Dept Endocrinol & Metab, Beijing 100044, Peoples R China.
EM jiln@bjmu.edu.cn
RI Linong, Ji/AAB-6543-2020
FU National High Technology Research and Development Program (863 Program)
   [2012AA02A509]; National Key Basic Research Program of China (973
   Program) [2011CB504000]; Beijing Science and Technology Committee
   [D131100005313008]
FX This work was supported through a grant from the National High
   Technology Research and Development Program (863 Program, 2012AA02A509).
   National Key Basic Research Program of China (973 Program,
   2011CB504000), and Beijing Science and Technology Committee Funding
   (D131100005313008). We thank all the participants for agreeing to join
   this study. We are grateful to the staff at PKU Diabetes Centre for
   their assistance with subject recruitment, conducting the clinical
   protocol, and laboratory testing. We are indebted to the technicians of
   BGI-Shenzhen for their practical work in this study.
CR Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   Caporaso JG, 2010, NAT METHODS, V7, P335, DOI 10.1038/nmeth.f.303
   Chiasson JL, 2002, LANCET, V359, P2072, DOI 10.1016/S0140-6736(02)08905-5
   Chiasson JL, 2003, JAMA-J AM MED ASSOC, V290, P486, DOI 10.1001/jama.290.4.486
   Chun J, 2010, BMC MICROBIOL, V10, DOI 10.1186/1471-2180-10-101
   Contreras A, 2000, ORAL MICROBIOL IMMUN, V15, P269, DOI 10.1034/j.1399-302x.2000.150410.x
   De Vadder F, 2014, CELL, V156, P84, DOI 10.1016/j.cell.2013.12.016
   Delaere F, 2013, MOL METAB, V2, P47, DOI 10.1016/j.molmet.2012.11.003
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Furet JP, 2010, DIABETES, V59, P3049, DOI 10.2337/db10-0253
   Gao ZG, 2009, DIABETES, V58, P1509, DOI 10.2337/db08-1637
   Hanefeld M, 2004, EUR HEART J, V25, P10, DOI 10.1016/S0195-668X(03)00468-8
   HIELE M, 1992, DIGEST DIS SCI, V37, P1057, DOI 10.1007/BF01300287
   Holt PR, 1996, METABOLISM, V45, P1179, DOI 10.1016/S0026-0495(96)90020-7
   Hooper LV, 2012, SCIENCE, V336, P1268, DOI 10.1126/science.1223490
   Joossens M, 2011, GUT, V60, P631, DOI 10.1136/gut.2010.223263
   Jumas-Bilak E, 2005, INT J SYST EVOL MICR, V55, P2471, DOI 10.1099/ijs.0.63715-0
   Kang JH, 2010, J MICROBIOL, V48, P712, DOI 10.1007/s12275-010-0363-8
   Knowler WC, 2002, NEW ENGL J MED, V346, P393, DOI 10.1056/NEJMoa012512
   Koren O, 2011, P NATL ACAD SCI USA, V108, P4592, DOI 10.1073/pnas.1011383107
   Lanjekar VB, 2014, INT J SYST EVOL MICR, V64, P2250, DOI 10.1099/ijs.0.059816-0
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Lepargneur JP, 2006, ANAEROBE, V12, P274, DOI 10.1016/j.anerobe.2006.07.004
   Li GW, 2014, LANCET DIABETES ENDO, V2, P474, DOI 10.1016/S2213-8587(14)70057-9
   Li WZ, 2006, BIOINFORMATICS, V22, P1658, DOI 10.1093/bioinformatics/btl158
   Morotomi M, 2008, INT J SYST EVOL MICR, V58, P2716, DOI 10.1099/ijs.0.2008/000810-0
   Naito E, 2011, J APPL MICROBIOL, V110, P650, DOI 10.1111/j.1365-2672.2010.04922.x
   Ott SJ, 2006, CIRCULATION, V113, P929, DOI 10.1161/CIRCULATIONAHA.105.579979
   Panwar H, 2014, EUR J NUTR, V53, P1465, DOI 10.1007/s00394-013-0649-9
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Quince C, 2011, BMC BIOINFORMATICS, V12, DOI 10.1186/1471-2105-12-38
   Rousee JM, 2002, J CLIN MICROBIOL, V40, P3871, DOI 10.1128/JCM.40.10.3871-3873.2002
   Shetty SA, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0079353
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Su BL, 2015, J DIABETES, V7, P729, DOI 10.1111/1753-0407.12232
   Tremaroli V, 2012, NATURE, V489, P242, DOI 10.1038/nature11552
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Wang Q, 2007, APPL ENVIRON MICROB, V73, P5261, DOI 10.1128/AEM.00062-07
   Weaver GA, 1997, J NUTR, V127, P717, DOI 10.1093/jn/127.5.717
   Wolever TMS, 2000, BRIT J NUTR, V84, P57
   WOLEVER TMS, 1995, DIABETIC MED, V12, P164, DOI 10.1111/j.1464-5491.1995.tb00448.x
   Yadav H, 2007, NUTRITION, V23, P62, DOI 10.1016/j.nut.2006.09.002
   Yang WY, 2014, LANCET DIABETES ENDO, V2, P46, DOI 10.1016/S2213-8587(13)70021-4
   Zhang XY, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0071108
NR 46
TC 100
Z9 112
U1 4
U2 20
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1869-6953
EI 1869-6961
J9 DIABETES THER
JI Diabetes Ther.
PD APR
PY 2017
VL 8
IS 2
BP 293
EP 307
DI 10.1007/s13300-017-0226-y
PG 15
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EW0CJ
UT WOS:000402155500008
PM 28130771
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Park, S
   Zhang, T
   Qiu, JY
   Wu, X
   Lee, JY
   Lee, BY
AF Park, Sunmin
   Zhang, Ting
   Qiu, Jing Yi
   Wu, Xuangao
   Lee, Jeong-Yong
   Lee, Boo-Yong
TI Acid Hydrolyzed Silk Peptide Consumption Improves Anti-Diabetic Symptoms
   by Potentiating Insulin Secretion and Preventing Gut Microbiome
   Dysbiosis in Non-Obese Type 2 Diabetic Animals
SO NUTRIENTS
LA English
DT Article
DE silk peptide; gut microbiome; Triglyceride; intestinal cells; glucose
   tolerance
ID BETA-CELL FUNCTION; GLUCOSE-METABOLISM; MASS; ESTROGEN; EXERCISE
AB Silk fibroin hydrolysates have been reported to reduce hyperglycemia, but the mechanism has not been determined in Asian type 2 diabetes (T2DM). We hypothesized that the consumption of acid hydrolyzed silk peptides (SPs) alleviates hyperglycemia by improving insulin sensitivity and subsequently normalizing glucose-stimulated insulin secretion in T2DM. We investigated this hypothesis in a partial pancreatectomized (Px) rat model. Px rats was assigned randomly to the following six groups and fed assigned diet for 8 weeks: the Px-control (0.5 g/kg/day dextrin), the SP-L (0.05 g/kg/day), the SP-M (0.1 g/kg/day), the SP-H (0.5 g/kg/day), the positive-control (40 mg/kg/day metformin), or the normal-control (sham-operated rats; 0.5 g/kg/day dextrin). SPs contained high levels of glycine, alanine, and serine. We found SPs dose-dependently increased food efficiency and body weight gain in Px rats. Animals in the Px-control group rats exhibited lower glucose metabolism, as evidenced by impaired glucose-stimulated insulin secretion coupled with impaired insulin sensitivity, and reduced bone mineral density (BMD) and lean body mass (LBM), compared to the normal-control. SPs and metformin similarly partially protected against Px-induced BMD loss in the lumbar spine and femur. Px-induced decreases in LBM were dose-dependently prevented by SPs, and muscle forces in the SP-M and SP-H groups were maintained at the normal-control level. Glucose tolerance was dose-dependently improved by SPs as determined by oral glucose tolerance and oral maltose tolerance tests, and glucose tolerances were similar in the SP-H and positive-control groups. Insulin tolerance, an index of insulin sensitivity, was dose-dependently enhanced by SPs, and the SP-H group exhibited better insulin tolerance than the positive-control group as determined by intraperitoneal insulin sensitivity testing. Insulin secretory capacity assessed using a hyperglycemic clamp improved in the following order: Px-control <SA-L <SA-M <positive-control <SA-H <normal-control. SP-M prevented gut microbiota dysbiosis. In conclusion, SPs administered at 0.1-0.5 g/kg/day improved glucose regulation by potentiating both insulin secretion and insulin sensitivity in non-obese T2DM rats.
C1 [Park, Sunmin; Zhang, Ting; Qiu, Jing Yi; Wu, Xuangao] Hoseo Univ, Dept Food & Nutr, Obes Diabet Ctr, Asan 31499, South Korea.
   [Lee, Jeong-Yong] Worldway Co Ltd, Jeonul Myeon 30003, Sejong Si, South Korea.
   [Lee, Boo-Yong] CHA Univ, Dept Food Sci & Biotechnol, Coll Biomed Sci, Seongnam 31499, South Korea.
C3 Hoseo University; Pochon Cha University
RP Park, S (通讯作者)，Hoseo Univ, Dept Food & Nutr, Obes Diabet Ctr, Asan 31499, South Korea.; Lee, BY (通讯作者)，CHA Univ, Dept Food Sci & Biotechnol, Coll Biomed Sci, Seongnam 31499, South Korea.
EM smpark@hoseo.edu; zhangting92925@gmail.com; yoyo099@163.com;
   niyani0@naver.com; bylee@cha.ac.kr; dalgoozi@hanmail.net
RI Park, Sun/GSD-9620-2022
OI Park, Sunmin/0000-0002-6092-8340
FU Ministry of Trade, Industry Energy (MOTIE); Korea Institute for
   Advancement of Technology (KIAT) through the Encouragement Program for
   The Industries of Economic Cooperation Region
FX This research was supported by the Ministry of Trade, Industry & Energy
   (MOTIE), and Korea Institute for Advancement of Technology (KIAT)
   through the Encouragement Program for The Industries of Economic
   Cooperation Region.
CR Alves A, 2019, NUTRIENTS, V11, DOI 10.3390/nu11061356
   Choi SB, 2005, ENDOCRINOLOGY, V146, P4786, DOI 10.1210/en.2004-1653
   Do SG, 2012, J VET SCI, V13, P339, DOI 10.4142/jvs.2012.13.4.339
   Dobbins RL, 2002, DIABETES, V51, P1825, DOI 10.2337/diabetes.51.6.1825
   Elbere I, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0204317
   Guo QW, 2019, INT J BIOL MACROMOL, V121, P981, DOI 10.1016/j.ijbiomac.2018.10.100
   HIKINO H, 1985, PLANTA MED, V51, P159, DOI 10.1055/s-2007-969435
   Hosokawa YA, 1996, J CLIN INVEST, V97, P180, DOI 10.1172/JCI118387
   Hyun CK, 2004, J NUTR, V134, P3257, DOI 10.1093/jn/134.12.3257
   Islam Md Shahidul, 2012, Methods Mol Biol, V933, P161, DOI 10.1007/978-1-62703-068-7_10
   Jung H, 2017, BIOCHEM BIOPH RES CO, V493, P115, DOI 10.1016/j.bbrc.2017.09.066
   Karusheva Y, 2019, AM J CLIN NUTR, V110, P1098, DOI 10.1093/ajcn/nqz191
   Ksenofontov AL, 2017, BIOCHEMISTRY-MOSCOW+, V82, P1183, DOI 10.1134/S000629791710011X
   Li L, 2001, ENDOCRINOLOGY, V142, P5379, DOI 10.1210/en.142.12.5379
   Ma RCW, 2013, ANN NY ACAD SCI, V1281, P64, DOI 10.1111/nyas.12098
   Madsen MSA, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-52103-x
   Mesgari-Abbasi M, 2022, ARCH PHYSIOL BIOCHEM, V128, P59, DOI 10.1080/13813455.2019.1662453
   Park Ji-Eun, 2019, Dev Reprod, V23, P223, DOI 10.12717/DR.2019.23.3.223
   Park SM, 2007, J APPL PHYSIOL, V103, P1764, DOI 10.1152/japplphysiol.00434.2007
   Park S, 2018, EXP BIOL MED, V243, P882, DOI 10.1177/1535370218789068
   Park S, 2011, EUR J NUTR, V50, P107, DOI 10.1007/s00394-010-0120-0
   REEVES PG, 1993, J NUTR, V123, P1939, DOI 10.1093/jn/123.11.1939
   Ryuk JA, 2019, J CLIN BIOCHEM NUTR, V65, P223, DOI 10.3164/jcbn.19-15
   Takeshita H, 2017, SCI REP-UK, V7, DOI 10.1038/srep42323
   Wang H, 2019, ACTA DIABETOL
   Wang HY, 2012, FOOD FUNCT, V3, P150, DOI 10.1039/c1fo10148j
   Weisman A, 2018, CAN J CARDIOL, V34, P552, DOI 10.1016/j.cjca.2018.03.002
   Xourgia E, 2019, FRONT BIOSCI-LANDMRK, V24, P688, DOI 10.2741/4743
   Yang HJ, 2018, NUTRIENTS, V10, DOI 10.3390/nu10070948
   Yang HJ, 2016, NUTRITION, V32, P129, DOI 10.1016/j.nut.2015.07.012
NR 30
TC 9
Z9 9
U1 1
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD FEB
PY 2020
VL 12
IS 2
AR 311
DI 10.3390/nu12020311
PG 16
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA KY3GF
UT WOS:000522458700038
PM 31991596
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Zhang, Q
   Xiao, XH
   Zheng, J
   Li, M
   Yu, M
   Ping, F
   Wang, T
   Wang, XJ
AF Zhang, Qian
   Xiao, Xinhua
   Zheng, Jia
   Li, Ming
   Yu, Miao
   Ping, Fan
   Wang, Tong
   Wang, Xiaojing
TI Featured article: Structure moderation of gut microbiota in
   liraglutide-treated diabetic male rats
SO EXPERIMENTAL BIOLOGY AND MEDICINE
LA English
DT Article
DE Diabetes; gut microbiota; glucagon-like peptide 1; short chain fatty
   acid; probiotic bacteria
ID HIGH-FAT-DIET; INDUCED OBESITY; INTESTINAL BARRIER; MICE; METABOLISM;
   MODULATION; DIVERSITY; SEQUENCES; METFORMIN; BUTYRATE
AB The change of gut microbiome is associated with a serious of metabolic disorders, such as diabetes. As a glucagon-like peptide 1 analogue, liraglutide is a potent antidiabetic drug in clinical practice. However, the effect of liraglutide on the community of gut microbiota is still unknown. We aimed to determine the influence of liraglutide on fecal microbiota in diabetic male rats. Five-week-old male Sprague-Dawley rats were fed with a control diet or a high-fat diet for four weeks. By injecting streptozotocin, the diabetic rat model was performed. Diabetic male rats were injected subcutaneously with a low dose of liraglutide (liraglutide 0.2 mg/kg/day), a high dose of liraglutide (liraglutide 0.4 mg/kg/day), or normal saline for 12 weeks. Our data showed that liraglutide effectively prevented the development of diabetes in male rats. Pyrosequencing of the V3-V4 region of 16S rRNA genes manifested a remarkable transfer of gut microbiota construction in liraglutide-treated male rats compared with that of the diabetic male rats. Further analysis identified 879 liraglutide-treated specific operational taxonomic units. Some short-chain fatty acid (SCFA)-producing bacteria, including Bacteroides, Lachnospiraceae, and probiotic bacteria, Bifidobacterium, were selectively enhanced in liraglutide-treated diabetic male rats. Lactobacillus was negatively correlated with fasting blood glucose. To sum up, our findings propose that the prevention of diabetes by liraglutide in the diabetic male rats may be associated with the structural change of the gut microbiota, inflammation alleviation, and abundantly elevated SCFA-producing bacteria in the intestine.
C1 [Zhang, Qian; Xiao, Xinhua; Zheng, Jia; Li, Ming; Yu, Miao; Ping, Fan; Wang, Tong; Wang, Xiaojing] Chinese Acad Med Sci, Key Lab Endocrinol, Translat Med Ctr,Peking Union Med Coll, Minist Hlth,Peking Union Med Coll Hosp,Dept Endoc, Beijing 100730, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College; Peking Union Medical College Hospital
RP Xiao, XH (通讯作者)，Chinese Acad Med Sci, Key Lab Endocrinol, Translat Med Ctr,Peking Union Med Coll, Minist Hlth,Peking Union Med Coll Hosp,Dept Endoc, Beijing 100730, Peoples R China.
EM xiaoxh2014@vip.163.com
RI Li, Ming/I-1323-2018
OI Li, Ming/0000-0002-8427-605X
FU National Key Research and Development Program of China [2016YFA0101002];
   National Natural Science Foundation of China [81170736, 81570715];
   National Natural Science Foundation for Young Scholars of China
   [81300649]; China Scholarship Council Foundation [201308110443]; PUMC
   Youth Fund [33320140022]; China Diabetes Young Scientific Talent
   Research Funding; Diabetes Research Fund from Clinical Research of
   Chinese Medical Association; Fundamental Research Funds for the Central
   Universities; Scientific Activities Foundation for Selected Returned
   Overseas Professional of Human Resources; Social Security Ministry;
   Chinese Diabetes Society [12030500350]
FX This work was supported by National Key Research and Development Program
   of China (2016YFA0101002), National Natural Science Foundation of China
   (81170736, 81570715), National Natural Science Foundation for Young
   Scholars of China (81300649), China Scholarship Council Foundation
   (201308110443), PUMC Youth Fund (33320140022), China Diabetes Young
   Scientific Talent Research Funding, Diabetes Research Fund from Clinical
   Research of Chinese Medical Association and Chinese Diabetes Society
   (12030500350), Fundamental Research Funds for the Central Universities,
   and the Scientific Activities Foundation for Selected Returned Overseas
   Professional of Human Resources and Social Security Ministry.
CR Asadi S, 2015, IRAN J BASIC MED SCI, V18, P537
   Boulange CL, 2016, GENOME MED, V8, DOI 10.1186/s13073-016-0303-2
   Burton Jeffrey H, 2015, J Diabetes Sci Technol, V9, P808, DOI 10.1177/1932296815577425
   Canfora EE, 2015, NAT REV ENDOCRINOL, V11, P577, DOI 10.1038/nrendo.2015.128
   Caporaso JG, 2010, NAT METHODS, V7, P335, DOI 10.1038/nmeth.f.303
   Denou E, 2016, AM J PHYSIOL-ENDOC M, V310, pE982, DOI 10.1152/ajpendo.00537.2015
   DeSantis TZ, 2006, APPL ENVIRON MICROB, V72, P5069, DOI 10.1128/AEM.03006-05
   Edgar RC, 2013, NAT METHODS, V10, P996, DOI [10.1038/nmeth.2604, 10.1038/NMETH.2604]
   Egshatyan L, 2016, ENDOCR CONNECT, V5, P1, DOI 10.1530/EC-15-0094
   Estaki M, 2016, MICROBIOME, V4, DOI 10.1186/s40168-016-0189-7
   Garcia-Mazcorro JF, 2016, PEERJ, V4, DOI 10.7717/peerj.1702
   Gibson GR, 2008, J CLIN GASTROENTEROL, V42, pS75, DOI 10.1097/MCG.0b013e31815ed097
   Gomes AC, 2014, NUTR J, V13, DOI 10.1186/1475-2891-13-60
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Lau E, 2016, NUTR METAB, V13, DOI 10.1186/s12986-016-0089-7
   Ley RE, 2005, P NATL ACAD SCI USA, V102, P11070, DOI 10.1073/pnas.0504978102
   Lozupone C, 2005, APPL ENVIRON MICROB, V71, P8228, DOI 10.1128/AEM.71.12.8228-8235.2005
   Magoc T, 2011, BIOINFORMATICS, V27, P2957, DOI 10.1093/bioinformatics/btr507
   Maniar K, 2017, PHARMACOL RES, V117, P103, DOI 10.1016/j.phrs.2016.12.003
   Ou JY, 2016, PLANT FOOD HUM NUTR, V71, P123, DOI 10.1007/s11130-016-0547-4
   Peng LY, 2007, PEDIATR RES, V61, P37, DOI 10.1203/01.pdr.0000250014.92242.f3
   Plaza-Diaz J, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0098401
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Rabot S, 2010, FASEB J, V24, P4948, DOI 10.1096/fj.10-164921
   Ross SA, 2010, CAN FAM PHYSICIAN, V56, P639
   Segata N, 2011, GENOME BIOL, V12, DOI 10.1186/gb-2011-12-6-r60
   Suzuki T, 2008, BRIT J NUTR, V100, P297, DOI 10.1017/S0007114508888733
   Turnbaugh PJ, 2008, CELL HOST MICROBE, V3, P213, DOI 10.1016/j.chom.2008.02.015
   Turnbaugh PJ, 2009, SCI TRANSL MED, V1, DOI 10.1126/scitranslmed.3000322
   Wang JJ, 2015, ISME J, V9, P1, DOI 10.1038/ismej.2014.99
   Wang Q, 2007, APPL ENVIRON MICROB, V73, P5261, DOI 10.1128/AEM.00062-07
   Wright DP, 2000, FEMS MICROBIOL LETT, V190, P73, DOI 10.1016/S0378-1097(00)00324-4
   Wu XK, 2010, CURR MICROBIOL, V61, P69, DOI 10.1007/s00284-010-9582-9
   Yan XF, 2016, J DIABETES RES, V2016, DOI 10.1155/2016/2093171
   Yoo JY, 2016, NUTRIENTS, V8, DOI 10.3390/nu8030173
   Zhang Q, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17101767
   Zhang XY, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0071108
   Zhang X, 2015, SCI REP-UK, V5, DOI 10.1038/srep14405
   Zhou CH, 2017, PAIN, V158, P130, DOI 10.1097/j.pain.0000000000000739
   Zhu Y, 2016, INT J FOOD SCI NUTR, V67, P686, DOI 10.1080/09637486.2016.1197185
NR 40
TC 42
Z9 47
U1 1
U2 19
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1535-3702
EI 1535-3699
J9 EXP BIOL MED
JI Exp. Biol. Med.
PD JAN
PY 2018
VL 243
IS 1
BP 34
EP 44
DI 10.1177/1535370217743765
PG 11
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA FS8IW
UT WOS:000422655400005
PM 29171288
OA Green Published
DA 2023-06-08
ER

PT J
AU Zhang, Q
   Xiao, XH
   Li, M
   Yu, M
   Ping, F
   Zheng, J
   Wang, T
   Wang, XJ
AF Zhang, Qian
   Xiao, Xinhua
   Li, Ming
   Yu, Miao
   Ping, Fan
   Zheng, Jia
   Wang, Tong
   Wang, Xiaojing
TI Vildagliptin increases butyrate-producing bacteria in the gut of
   diabetic rats
SO PLOS ONE
LA English
DT Article
ID HIGH-FAT-DIET; INDUCED OBESITY; MICROBIOTA INTERACTIONS; INTESTINAL
   MICROBIOTA; INSULIN-RESISTANCE; INFLAMMATION; METFORMIN; RNA;
   IMPROVEMENT; MODULATION
AB Emerging evidence supports a key role for the gut microbiota in metabolic diseases, including type 2 diabetes (T2D) and obesity. The dipeptidyl peptidase-4 inhibitor vildagliptin is highly efficacious in treating T2D. However, whether vildagliptin can alter the gut microbiome is still unclear. This study aimed to identify whether vildagliptin modifies the gut microbiota structure during T2D treatment. Diabetic Sprague-Dawley (SD) rats were induced by a high-fat diet and streptozotocin injection (HFD/STZ). Diabetic rats were orally administered a low dose of vildagliptin (LV, 0.01 g/kg/d vildagliptin), high dose of vildagliptin (HV, 0.02 g/kg/d vildagliptin), or normal saline for 12 weeks. Fasting blood glucose, blood glucose after glucose loading, and serum insulin levels were significantly reduced in the LV and HV groups compared with those in the T2D group. The serum GLP-1 level increased more in the vildagliptin-treated group than in the T2D group. Pyrosequencing of the V3-V4 regions of 16S rRNA genes revealed that vildagliptin significantly altered the gut microbiota. The operational taxonomic units (OTUs) and community richness (Chao1) index were significantly reduced in the vildagliptin and diabetic groups compared with those in the control group. At the phylum level, a higher relative abundance of Bacteroidetes, lower abundance of Firmicutes, and reduced ratio of Fimicutes/Bacteroidetes were observed in the vildagliptin-treated group. Moreover, vildagliptin treatment increased butyrate-producing bacteria, including Baceroides and Erysipelotrichaeae, in the diabetic rats. Moreover, Lachnospira abundance was significantly negatively correlated with fasting blood glucose levels. In conclusion, vildagliptin treatment could benefit the communities of the gut microbiota.
C1 [Zhang, Qian; Xiao, Xinhua; Li, Ming; Yu, Miao; Ping, Fan; Zheng, Jia; Wang, Tong; Wang, Xiaojing] Chinese Acad Med Sci, Peking Union Med Coll, Peking Union Med Coll Hosp,Key Lab Endocrinol, Dept Endocrinol,Translat Med Ctr,Minist Hlth, Beijing, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College; Peking Union Medical College Hospital
RP Xiao, XH (通讯作者)，Chinese Acad Med Sci, Peking Union Med Coll, Peking Union Med Coll Hosp,Key Lab Endocrinol, Dept Endocrinol,Translat Med Ctr,Minist Hlth, Beijing, Peoples R China.
EM xiaoxh2014@vip.163.com
RI Li, Ming/I-1323-2018
OI Li, Ming/0000-0002-8427-605X
FU National Key Research and Development Program of China [2016YFA0101002];
   National Natural Science Foundation of China [81170736, 81570715];
   National Natural Science Foundation for Young Scholars of China
   [81300649]; China Scholarship Council Foundation [201308110443]; PUMC
   Youth Fund [33320140022]; China Diabetes Young Scientific Talent
   Research Funding, Diabetes Research Fund from Clinical Research of
   Chinese Medical Association and Chinese Diabetes Society [12030500350];
   Fundamental Research Funds for the Central Universities; Scientific
   Activities Foundation for Selected Returned Overseas Professional of
   Human Resources and Social Security Ministry
FX This work was supported by National Key Research and Development Program
   of China (2016YFA0101002), National Natural Science Foundation of China
   (81170736, 81570715), National Natural Science Foundation for Young
   Scholars of China (81300649), China Scholarship Council Foundation
   (201308110443), PUMC Youth Fund (33320140022), China Diabetes Young
   Scientific Talent Research Funding, Diabetes Research Fund from Clinical
   Research of Chinese Medical Association and Chinese Diabetes Society
   (12030500350), Fundamental Research Funds for the Central Universities,
   and the Scientific Activities Foundation for Selected Returned Overseas
   Professional of Human Resources and Social Security Ministry. The
   funders had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.; l
CR Alles MS, 1996, BRIT J NUTR, V76, P211, DOI 10.1079/BJN19960026
   Baothman OA, 2016, LIPIDS HEALTH DIS, V15, DOI 10.1186/s12944-016-0278-4
   BEERENS H, 1977, AM J CLIN NUTR, V30, P1770, DOI 10.1093/ajcn/30.11.1770
   Bosi E, 2007, DIABETES CARE, V30, P890, DOI 10.2337/dc06-1732
   Candela M, 2016, BRIT J NUTR, V116, P80, DOI 10.1017/S0007114516001045
   Cani PD, 2009, GUT, V58, P1091, DOI 10.1136/gut.2008.165886
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Cani PD, 2012, GUT MICROBES, V3, P279, DOI 10.4161/gmic.19625
   Cani PD, 2009, CURR PHARM DESIGN, V15, P1546, DOI 10.2174/138161209788168164
   Caporaso JG, 2010, NAT METHODS, V7, P335, DOI 10.1038/nmeth.f.303
   Chang CJ, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms8489
   Cotillard A, 2013, NATURE, V500, P585, DOI 10.1038/nature12480
   David LA, 2014, NATURE, V505, P559, DOI 10.1038/nature12820
   DeSantis TZ, 2006, APPL ENVIRON MICROB, V72, P5069, DOI 10.1128/AEM.03006-05
   Devkota S, 2012, NATURE, V487, P104, DOI 10.1038/nature11225
   Edgar RC, 2013, NAT METHODS, V10, P996, DOI [10.1038/nmeth.2604, 10.1038/NMETH.2604]
   Estaki M, 2016, MICROBIOME, V4, DOI 10.1186/s40168-016-0189-7
   Esteve E, 2011, CURR OPIN CLIN NUTR, V14, P483, DOI 10.1097/MCO.0b013e328348c06d
   Furet JP, 2010, DIABETES, V59, P3049, DOI 10.2337/db10-0253
   Hildebrandt MA, 2009, GASTROENTEROLOGY, V137, P1716, DOI 10.1053/j.gastro.2009.08.042
   Holodniy M, 2011, PLOS ONE, V6, DOI [10.1371/journal.pone.0014764, 10.1371/journal.pone.0025792]
   Holtcamp W, 2012, ENVIRON HEALTH PERSP, V120, pA123, DOI 10.1289/ehp.120-a123a
   Jung MJ, 2016, SCI REP-UK, V6, DOI 10.1038/srep30887
   Kimura I, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms2852
   Kubeck R, 2016, MOL METAB, V5, P1162, DOI 10.1016/j.molmet.2016.10.001
   Lam YY, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0034233
   Le Chatelier E, 2013, NATURE, V500, P541, DOI 10.1038/nature12506
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Ley RE, 2005, P NATL ACAD SCI USA, V102, P11070, DOI 10.1073/pnas.0504978102
   Loubinoux J, 2000, J CLIN MICROBIOL, V38, P931, DOI 10.1128/JCM.38.2.931-934.2000
   Lozupone C, 2005, APPL ENVIRON MICROB, V71, P8228, DOI 10.1128/AEM.71.12.8228-8235.2005
   Maniar K, 2017, PHARMACOL RES, V117, P103, DOI 10.1016/j.phrs.2016.12.003
   Mouzaki M, 2013, HEPATOLOGY, V58, P120, DOI 10.1002/hep.26319
   Murphy EF, 2010, GUT, V59, P1635, DOI 10.1136/gut.2010.215665
   Rabot S, 2010, FASEB J, V24, P4948, DOI 10.1096/fj.10-164921
   Ross SA, 2010, CAN FAM PHYSICIAN, V56, P639
   Samah S, 2016, DIABETES RES CLIN PR, V118, P172, DOI 10.1016/j.diabres.2016.06.014
   Samuel BS, 2008, P NATL ACAD SCI USA, V105, P16767, DOI 10.1073/pnas.0808567105
   Segata N, 2011, GENOME BIOL, V12, DOI 10.1186/gb-2011-12-6-r60
   Tai NW, 2015, REV ENDOCR METAB DIS, V16, P55, DOI 10.1007/s11154-015-9309-0
   Tappenden KA, 1998, AM J CLIN NUTR, V68, P118, DOI 10.1093/ajcn/68.1.118
   Tappenden KA, 1998, DIGEST DIS SCI, V43, P1526, DOI 10.1023/A:1018819032620
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Wang Q, 2007, APPL ENVIRON MICROB, V73, P5261, DOI 10.1128/AEM.00062-07
   Weglarz L, 2003, CELL MOL BIOL LETT, V8, P991
   Wong JMW, 2006, J CLIN GASTROENTEROL, V40, P235, DOI 10.1097/00004836-200603000-00015
   Wu XK, 2010, CURR MICROBIOL, V61, P69, DOI 10.1007/s00284-010-9582-9
   Xie GX, 2016, ONCOTARGET, V7, P19355, DOI 10.18632/oncotarget.8466
   Xiong T, 2020, SENSOR ACTUAT B-CHEM, V304, DOI [10.1126/scitranslmed.3009124, 10.1016/j.snb.2019.127310]
   Zhang CH, 2010, ISME J, V4, P232, DOI 10.1038/ismej.2009.112
   Zhang Q, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17101767
   Zhang X, 2012, PLOS ONE, V7, DOI [10.1371/journal.pone.0040320, 10.1371/journal.pone.0042529]
   Zhang XY, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0071108
   Zhang X, 2015, SCI REP-UK, V5, DOI 10.1038/srep14405
   Zhu Y, 2016, INT J FOOD SCI NUTR, V67, P686, DOI 10.1080/09637486.2016.1197185
NR 55
TC 60
Z9 72
U1 1
U2 31
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD OCT 16
PY 2017
VL 12
IS 10
AR e0184735
DI 10.1371/journal.pone.0184735
PG 16
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA FJ8YP
UT WOS:000413054800003
PM 29036231
OA Green Submitted, Green Published, gold
DA 2023-06-08
ER

PT J
AU Niu, D
   An, SJ
   Chen, X
   Bi, HL
   Zhang, QS
   Wang, T
   Han, BK
   Zhang, HF
   Kang, JF
AF Niu, Dou
   An, Shujing
   Chen, Xue
   Bi, Huailong
   Zhang, Qiusheng
   Wang, Ting
   Han, Binkai
   Zhang, Huafeng
   Kang, Jiefang
TI Corni Fructus as a Natural Resource Can Treat Type 2 Diabetes by
   Regulating Gut Microbiota
SO AMERICAN JOURNAL OF CHINESE MEDICINE
LA English
DT Article
DE Corni Fructus; Gut Microbiota; Hypoglycemic Activity; SCFAs; Type 2
   Diabetes
ID PROTEIN-COUPLED RECEPTORS; FATTY-ACIDS; INFLAMMATION; ASSOCIATION;
   MELLITUS
AB Accumulating evidence suggests that gut microbiota plays a crucial role in the development of metabolic diseases, especially type 2 diabetes mellitus (T2DM). The nutrient-rich resource Cornus Fructus (CF) showed curative effects on diabetes mellitus. However, the mechanism underlying its hyperglycemic activity remains obscure. Herein, the antidiabetic potential of four extracts from CF, including saponin (CTS), iridoid glycoside (CIG), tannin (CT), and alcohol extract (CCA) was evaluated in vivo. The results showed that all four extracts could increase the body weight, decrease the blood glucose levels, and elevate the glucose tolerance. Moreover, insulin sensitivity and lipid profile were significantly improved in fed mice. In the a-diversity index of samples, compared to the DM group, the diversity and richness of gut microbiota in mice to a certain extent were reduced in both CF extracts and Metformin (PC). Among them, there was statistical significance in PC (ACE, p = 0:01) and CCA (ACE, p = 0:01; chao1: p = 0:04). Beta diversity showed the same trend as the UPGMA clustering trees, which revealed that CF extracts could improve intestinal homeostasis in T2DM mice. Also, CF extracts could elevate the production of short-chain fatty acids, as well as regulate the composition of gut microbiota. The key bacteria related to T2DM including Firmicutes, Bacteroides, Lactobacillus, and Clostridium were modulated by metformin and CF. Altogether, CF is a potential nutrient-rich candidate that can be used in functional foods for the treatment of T2DM, and the change of gut microbiota might be a novel mechanism underlying its hyperglycemic activity.
C1 [Niu, Dou; An, Shujing; Chen, Xue; Bi, Huailong; Zhang, Qiusheng; Wang, Ting; Han, Binkai; Kang, Jiefang] Shaanxi Normal Univ, Minist Educ Med Resources & Nat Pharmaceut Chem, Natl Engn Lab Resource Dev Endangered Crude Drugs, Key Lab,Coll Life Sci, Xian 710062, Shaanxi, Peoples R China.
   [Zhang, Huafeng] Shaanxi Normal Univ, Int Joint Res Ctr Shaanxi Prov Food & Hlth Sci, Coll Food Engn & Nutr Sci, Xian 710062, Shaanxi, Peoples R China.
C3 Shaanxi Normal University; Shaanxi Normal University
RP Kang, JF (通讯作者)，Shaanxi Normal Univ, Minist Educ Med Resources & Nat Pharmaceut Chem, Natl Engn Lab Resource Dev Endangered Crude Drugs, Key Lab,Coll Life Sci, Xian 710062, Shaanxi, Peoples R China.; Zhang, HF (通讯作者)，Shaanxi Normal Univ, Int Joint Res Ctr Shaanxi Prov Food & Hlth Sci, Coll Food Engn & Nutr Sci, Xian 710062, Shaanxi, Peoples R China.
EM isaacsau@sohu.com; kangjiefang@snnu.edu.cn
OI Kang, Jiefang/0000-0002-8082-7256
FU National Key Technologies Research and Development Program for
   Modernization of Traditional Chinese Medicine [2017YFC1701302];
   Fundamental Research Funds for the Central Universities [GK201706012];
   major Project of Shaanxi Province, China [2020ZDLSF05-10]
FX This work received supported from the National Key Technologies Research
   and Development Program for Modernization of Traditional Chinese
   Medicine (Grant No. 2017YFC1701302), the Fundamental Research Funds for
   the Central Universities (Grant No. GK201706012) and the major Project
   of Shaanxi Province, China (Grant No. 2020ZDLSF05-10). The authors also
   acknowledge the efforts executed by Dr. Laxman Pujari for language and
   grammar editing.
CR Allin KH, 2015, EUR J ENDOCRINOL, V172, pR167, DOI 10.1530/EJE-14-0874
   Bindels LB, 2013, TRENDS PHARMACOL SCI, V34, P226, DOI 10.1016/j.tips.2013.02.002
   Chen C, 2018, FOOD FUNCT, V9, P3732, DOI [10.1039/C7FO01346A, 10.1039/c7fo01346a]
   Delzenne NM, 2015, DIABETOLOGIA, V58, P2206, DOI 10.1007/s00125-015-3712-7
   Ding Xia, 2008, Zhongguo Zhong Yao Za Zhi, V33, P392
   Dong Y, 2018, CHIN MED-UK, V13, DOI 10.1186/s13020-018-0191-z
   Eckburg PB, 2005, SCIENCE, V308, P1635, DOI 10.1126/science.1110591
   Everard A, 2014, REV ENDOCR METAB DIS, V15, P189, DOI 10.1007/s11154-014-9288-6
   Frost G, 2014, NAT COMMUN, V5, DOI 10.1038/ncomms4611
   Gilbert ER, 2011, EXP DIABETES RES, DOI 10.1155/2011/416254
   Gross B, 2017, NAT REV ENDOCRINOL, V13, P36, DOI 10.1038/nrendo.2016.135
   Gursoy N., 2000, J DIABETES CLIN RES, V50, P51
   Han JL, 2014, WORLD J GASTROENTERO, V20, P17737, DOI 10.3748/wjg.v20.i47.17737
   He J, 2015, SCI REP, V5
   Hill JH, 2016, ELIFE, V5, DOI 10.7554/eLife.20145
   Huang J, 2018, J ETHNOPHARMACOL, V213, P280, DOI 10.1016/j.jep.2017.11.010
   Li J.J., 2003, J FOOD SCI
   Lin HV, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0035240
   Liu Xu-dong, 2015, Zhongguo Zhong Yao Za Zhi, V40, P4908
   Long J, 2017, J PERIODONTAL RES, V52, P636, DOI 10.1111/jre.12432
   Lontchi-Yimagou E, 2013, CURR DIABETES REP, V13, P435, DOI 10.1007/s11892-013-0375-y
   Ma ZJ, 2013, J DIABETES RES, V2013, DOI 10.1155/2013/452537
   Ma ZA, 2012, EXP DIABETES RES, DOI 10.1155/2012/703538
   Muoio DM, 2008, NAT REV MOL CELL BIO, V9, P193, DOI 10.1038/nrm2327
   Navab-Moghadam F, 2017, MICROB PATHOGENESIS, V110, P630, DOI 10.1016/j.micpath.2017.07.034
   Nicholson JK, 2012, SCIENCE, V336, P1262, DOI 10.1126/science.1223813
   Oh DY, 2011, CURR OPIN CLIN NUTR, V14, P322, DOI 10.1097/MCO.0b013e3283479230
   Reichardt N. S.H., 2017, ISME J, V8, P1352
   Reimann F, 2012, CELL METAB, V15, P421, DOI 10.1016/j.cmet.2011.12.019
   Roberts CK, 2009, LIFE SCI, V84, P705, DOI 10.1016/j.lfs.2009.02.026
   Rocha A, 2013, J NEPHROL, V26, P55, DOI 10.5301/jn.5000166
   Shang HX, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0154373
   Song Xiao-Yan, 2004, Zhongguo Zhong Xi Yi Jie He Za Zhi, V24, P1087
   Tolhurst G, 2012, DIABETES, V61, P364, DOI 10.2337/db11-1019
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Xiao SM, 2014, FEMS MICROBIOL ECOL, V87, P357, DOI 10.1111/1574-6941.12228
   Xu Fangfang, 2017, Zhongguo Yi Xue Ke Xue Yuan Xue Bao, V39, P324, DOI 10.3881/j.issn.1000-503X.2017.03.005
   Yokozawa T, 2010, DRUG DISCOV THER, V4, P223
   권승혁, 2009, [Journal of the Korean Society of Food Science and Nutrition, 한국식품영양과학회지], V38, P287
   Zhang HF, 2012, NATURE, V482, P35, DOI 10.1038/482035e
   Zhang MX, 2017, FOOD FUNCT, V8, P3696, DOI [10.1039/c7fo00712d, 10.1039/C7FO00712D]
NR 41
TC 15
Z9 16
U1 1
U2 21
PU WORLD SCIENTIFIC PUBL CO PTE LTD
PI SINGAPORE
PA 5 TOH TUCK LINK, SINGAPORE 596224, SINGAPORE
SN 0192-415X
EI 1793-6853
J9 AM J CHINESE MED
JI Am. J. Chin. Med.
PY 2020
VL 48
IS 6
BP 1385
EP 1407
DI 10.1142/S0192415X20500688
PG 23
WC Integrative & Complementary Medicine; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine; General & Internal Medicine
GA NZ8EI
UT WOS:000577334500007
PM 32907359
DA 2023-06-08
ER

PT J
AU Chen, FW
   He, LA
   Li, JL
   Yang, SH
   Zhang, BZ
   Zhu, D
   Wu, ZZ
   Zhang, S
   Hou, DC
   Ouyang, C
   Yi, JF
   Xiao, CX
   Hou, KJ
AF Chen, Fengwu
   He, Lina
   Li, Jilin
   Yang, Shuhui
   Zhang, Bangzhou
   Zhu, Dan
   Wu, Zezhen
   Zhang, Shuo
   Hou, Ducheng
   Ouyang, Cong
   Yi, Jianfeng
   Xiao, Chuanxing
   Hou, Kaijian
TI Polyethylene Glycol Loxenatide Injection (GLP-1) Protects Vascular
   Endothelial Cell Function in Middle-Aged and Elderly Patients With Type
   2 Diabetes by Regulating Gut Microbiota
SO FRONTIERS IN MOLECULAR BIOSCIENCES
LA English
DT Article
DE GLP-1; type 2 diabetes mellitus; gut microbiota; vascular endothelial
   cells; middle-aged
ID GLUCAGON-LIKE PEPTIDE-1; ANALOG LIRAGLUTIDE; METAGENOME; METFORMIN
AB Objective: To evaluate the protective effect of Polyethylene Glycol Loxenatide Injection (Glucagon-like peptide-1, GLP-1) on endothelial cells from middle-aged and elderly patients with newly diagnosed or poorly controlled type 2 diabetes mellitus (T2DM). GLP-1 weekly formulation was analyzed for cardiovascular disease protection and correlated with intestinal flora.Design: Stool samples were collected from middle-aged and elderly patients with new-onset or poorly controlled type 2 diabetes in Longhu People's Hospital and Shantou Central Hospital from June 2019 to November 2019. Samples were collected at week 0, 4, and 8 of treatment with GLP-1 weekly formulations. Samples were analyzed for metagenomic sequencing. Analysis was performed to compare the characteristics of the gut microbiota at week 0, 4, and 8 of GLP-1 treatment and to correlate different microbiota with characteristic clinical parameters.Results: Statistical differences were found in blood glucose lowering, cardiovascular endothelial, and inflammation-related indices between week 0 and W4 and in blood glucose lowering and cardiovascular endothelial indices from week 0 to 8 in the newly diagnosed or poorly controlled type 2 diabetic patients treated with GLP-1. Changes in gut microbiota at week 0, 4, and 8 after using GLP-1 were not statistically different, but had an overall trend of rising and then falling, and with different bacteria, that were correlated with different clinical indicators.Conclusion: GLP-1 improves endothelial cell function indicators in middle-aged and elderly diabetic patients, which may be related to its alteration of the population numbers of gut microbiota such as Acinetobacter, Eubacterium ramulus ATCC 29099, and Bacteroides_faecis. This study provides a guidance for the treatment of type 2 diabetic patients.
C1 [Chen, Fengwu; Wu, Zezhen; Zhang, Shuo; Hou, Kaijian] Shantou Univ, Affiliated Hosp 1, Med Coll, Shantou, Peoples R China.
   [Chen, Fengwu; Zhu, Dan; Wu, Zezhen; Zhang, Shuo; Hou, Ducheng; Hou, Kaijian] Longhu Peoples Hosp, Dept Endocrine & Metab Dis, Shantou, Peoples R China.
   [He, Lina; Yi, Jianfeng] Yichun Univ, Key Lab Res Act Ingredients Nat Med Jiangxi Prov, Yichun, Peoples R China.
   [Li, Jilin] Shantou Univ, Affiliated Hosp 2, Dept Cardiol, Med Coll, Shantou, Peoples R China.
   [Yang, Shuhui] Shantou Cent Hosp, Dept Endocrine & Metab Dis, Shantou, Peoples R China.
   [Zhang, Bangzhou; Xiao, Chuanxing] Fujian Univ Tradit Chinese Med, Sch Pharm, Fuzhou, Peoples R China.
   [Zhang, Bangzhou; Xiao, Chuanxing; Hou, Kaijian] Cent South Univ, Sch Basic Med Sci, Changsha, Peoples R China.
   [Ouyang, Cong] Xiamen Treatgut Biotechnol Co Ltd, Ctr Res & Dev, Xiamen, Peoples R China.
   [Xiao, Chuanxing] Fujian Univ Tradit Chinese Med, Affiliated Hosp 2, Dept Gastroenterol, Fuzhou, Peoples R China.
C3 Shantou University; Yichun University; Shantou University; Fujian
   University of Traditional Chinese Medicine; Central South University;
   Fujian University of Traditional Chinese Medicine
RP Hou, KJ (通讯作者)，Shantou Univ, Affiliated Hosp 1, Med Coll, Shantou, Peoples R China.; Hou, KJ (通讯作者)，Longhu Peoples Hosp, Dept Endocrine & Metab Dis, Shantou, Peoples R China.; Xiao, CX (通讯作者)，Fujian Univ Tradit Chinese Med, Sch Pharm, Fuzhou, Peoples R China.; Xiao, CX; Hou, KJ (通讯作者)，Cent South Univ, Sch Basic Med Sci, Changsha, Peoples R China.; Xiao, CX (通讯作者)，Fujian Univ Tradit Chinese Med, Affiliated Hosp 2, Dept Gastroenterol, Fuzhou, Peoples R China.
EM xiaoxx@163.com; kaijianhou@126.com
RI Li, Jilin/GOP-3462-2022; Hou, Kaijian/GVU-1115-2022
OI Hou, Kaijian/0000-0003-1733-0068
FU Shantou science and technology project [200812225264260]
FX Funding This study was supported by Shantou science and technology
   project (No: 200812225264260).
CR Aitken JD, 2013, NAT REV GASTRO HEPAT, V10, P72, DOI 10.1038/nrgastro.2012.252
   Allin KH, 2018, DIABETOLOGIA, V61, P810, DOI 10.1007/s00125-018-4550-1
   Allin KH, 2015, EUR J ENDOCRINOL, V172, pR167, DOI 10.1530/EJE-14-0874
   Andrikou E, 2019, HELL J CARDIOL, V60, P347, DOI 10.1016/j.hjc.2018.11.008
   Bielka W, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23010480
   Burton Jeffrey H, 2015, J Diabetes Sci Technol, V9, P808, DOI 10.1177/1932296815577425
   Cao X.-H., 2015, WORLD CHIN J DIGESTO, V23, P2507, DOI [10.11569/wcjd.v23.i15.2507, DOI 10.11569/WCJD.V23.I15.2507]
   de Moraes G, 2016, CLIN EXP OPHTHALMOL, V44, P838, DOI 10.1111/ceo.12795
   Gurung M, 2020, EBIOMEDICINE, V51, DOI 10.1016/j.ebiom.2019.11.051
   Helmstadter J, 2020, ARTERIOSCL THROM VAS, V40, P145, DOI 10.1161/atv.0000615456.97862.30
   Hwang I, 2015, FASEB J, V29, P2397, DOI 10.1096/fj.14-265983
   Ipp E, 2017, NEW ENGL J MED, V376, P890, DOI 10.1056/NEJMc1615712
   Jayalakshmi K, 2009, J GASTROINTEST LIVER, V18, P27
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kasai C, 2015, BMC GASTROENTEROL, V15, DOI 10.1186/s12876-015-0330-2
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Li JH, 2014, NAT BIOTECHNOL, V32, P834, DOI 10.1038/nbt.2942
   Lozupone CA, 2012, NATURE, V489, P220, DOI 10.1038/nature11550
   Ma QT, 2019, BIOMED PHARMACOTHER, V117, DOI 10.1016/j.biopha.2019.109138
   Madsen MSA, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-52103-x
   Mair P, 2015, P NATL ACAD SCI USA, V112, P14788, DOI 10.1073/pnas.1506047112
   Nadkarni P, 2014, PROG MOL BIOL TRANSL, V121, P23, DOI 10.1016/B978-0-12-800101-1.00002-8
   Neri AKM, 2021, BIOMARK MED, V15, P561, DOI 10.2217/bmm-2020-0611
   Nyborg NCB, 2012, DIABETES, V61, P1243, DOI 10.2337/db11-0936
   Paradis E., 2004, BIOINFORMATICS, V20, P289, DOI [DOI 10.1093/bioinformatics/btg412, DOI 10.1093/BIOINFORMATICS/BTG412]
   Pratley RE, 2012, DIABETES CARE, V35, P1986, DOI 10.2337/dc11-2113
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Que YY, 2021, FRONT IMMUNOL, V12, DOI 10.3389/fimmu.2021.722206
   Rutten GEHM, 2016, DIABETOL METAB SYNDR, V8, DOI 10.1186/s13098-016-0153-5
   Salamon D, 2018, POL ARCH INTERN MED, V128, P336, DOI 10.20452/pamw.4246
   Sedighi M, 2017, MICROB PATHOGENESIS, V111, P362, DOI 10.1016/j.micpath.2017.08.038
   Segata N, 2012, NAT METHODS, V9, P811, DOI [10.1038/NMETH.2066, 10.1038/nmeth.2066]
   Smits MM, 2021, DIABETES METAB, V47, DOI 10.1016/j.diabet.2021.101223
   Su BL, 2015, J DIABETES, V7, P729, DOI 10.1111/1753-0407.12232
   Sun Yu., 2014, THESIS ZHENGZHOU U C
   Tay HM, 2021, LAB CHIP, V21, P2511, DOI 10.1039/d1lc00333j
   Vanhoutte PM, 2017, ACTA PHYSIOL, V219, P22, DOI 10.1111/apha.12646
   Vanhoutte PM, 2016, CIRC RES, V119, P375, DOI 10.1161/CIRCRESAHA.116.306531
   Vanhoutte PM, 2009, ARTERIOSCL THROM VAS, V29, P1156, DOI 10.1161/ATVBAHA.109.190215
   Vikram A, 2016, NAT COMMUN, V7, DOI 10.1038/ncomms12565
   Wang DJ, 2013, DIABETES, V62, P1697, DOI 10.2337/db12-1025
   Wang L, 2016, SCI REP-UK, V6, DOI [10.1038/srep38380, 10.1038/srep33251, 10.1038/srep20004]
   Wang XL, 2021, MOL MED REP, V23, DOI 10.3892/mmr.2021.12113
   Wickham H, 2009, USE R, P1, DOI 10.1007/978-0-387-98141-3_1
   Wu XK, 2010, CURR MICROBIOL, V61, P69, DOI 10.1007/s00284-010-9582-9
   Xu J., 2013, J MED INNOVATION CHI, V10, P37
   Xu N., 2014, J CHINSES J DIABETES, V22, P731
   Yang LX, 2020, SCI TOTAL ENVIRON, V741, DOI 10.1016/j.scitotenv.2020.140423
   Zhang Q, 2018, EXP BIOL MED, V243, P34, DOI 10.1177/1535370217743765
   Zhang ZH, 2016, ANN TRANSL MED, V4, DOI 10.3978/j.issn.2305-5839.2016.01.33
   Zhou L., 2019, J CHINA PHARM J, V28, P96
NR 52
TC 6
Z9 6
U1 1
U2 12
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-889X
J9 FRONT MOL BIOSCI
JI Front. Mol. Biosci.
PD JUN 15
PY 2022
VL 9
AR 879294
DI 10.3389/fmolb.2022.879294
PG 15
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 2M9DO
UT WOS:000817991700001
PM 35782875
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Khan, S
   Luck, H
   Winer, S
   Winer, DA
AF Khan, Saad
   Luck, Helen
   Winer, Shawn
   Winer, Daniel A.
TI Emerging concepts in intestinal immune control of obesity-related
   metabolic disease
SO NATURE COMMUNICATIONS
LA English
DT Review
ID INNATE LYMPHOID-CELLS; WHITE ADIPOSE-TISSUE; CHAIN FATTY-ACIDS;
   INSULIN-RESISTANCE; GUT MICROBIOTA; T-CELLS; GLUCOSE-HOMEOSTASIS;
   SECRETING CELLS; HOST; RECEPTOR
AB At the centre of intestinal health and the fight against obesity and metabolic syndrome is the intestinal microbiota and its interaction with our immune systems. Here the authors Review the current understanding of how these systems interact and how we can capitalize on recent advances to provide better therapeutic options.
   The intestinal immune system is an important modulator of glucose homeostasis and obesity-associated insulin resistance. Dietary factors, the intestinal microbiota and their metabolites shape intestinal immunity during obesity. The intestinal immune system in turn affects processes such as intestinal permeability, immune cell trafficking, and intestinal hormone availability, impacting systemic insulin resistance. Understanding these pathways might identify mechanisms underlying treatments for insulin resistance, such as metformin and bariatric surgery, or aid in developing new therapies and vaccination approaches. Here, we highlight evolving concepts centered on intestinal immunity, diet, and the microbiota to provide a working model of obesity-related metabolic disease.
C1 [Khan, Saad; Winer, Daniel A.] Univ Toronto, Dept Immunol, Toronto, ON, Canada.
   [Khan, Saad; Luck, Helen; Winer, Daniel A.] Univ Hlth Network, Toronto Gen Hosp Res Inst TGHRI, Diabet Res Grp, Div Cellular & Mol Biol, Toronto, ON, Canada.
   [Winer, Shawn; Winer, Daniel A.] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada.
   [Winer, Shawn] St Michaels Hosp, Dept Lab Med, Toronto, ON, Canada.
   [Winer, Daniel A.] Univ Hlth Network, Dept Pathol, Toronto, ON, Canada.
   [Winer, Daniel A.] Buck Inst Res Aging, Novato, CA 94945 USA.
C3 University of Toronto; University of Toronto; University Health Network
   Toronto; University of Toronto; University of Toronto; Saint Michaels
   Hospital Toronto; University of Toronto; University Health Network
   Toronto; Buck Institute for Research on Aging
RP Winer, DA (通讯作者)，Univ Toronto, Dept Immunol, Toronto, ON, Canada.; Winer, DA (通讯作者)，Univ Hlth Network, Toronto Gen Hosp Res Inst TGHRI, Diabet Res Grp, Div Cellular & Mol Biol, Toronto, ON, Canada.; Winer, DA (通讯作者)，Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada.; Winer, DA (通讯作者)，Univ Hlth Network, Dept Pathol, Toronto, ON, Canada.; Winer, DA (通讯作者)，Buck Inst Res Aging, Novato, CA 94945 USA.
EM dwiner@buckinstitute.org
FU Ontario Graduate Scholarship (OGS); Banting & Best Center
   (BBDC)-University Health Network Graduate Award; Canadian Institutes of
   Health Research (CIHR) New Investigator Foundation Grant [FDN-148385];
   Canadian Liver Foundation; Ontario Ministry of Innovation Early
   Researcher Award
FX S.K. is a recipient of the Ontario Graduate Scholarship (OGS), and the
   Banting & Best Center (BBDC)-University Health Network Graduate Award.
   D.A.W. is funded by a Canadian Institutes of Health Research (CIHR) New
   Investigator Foundation Grant FDN-148385 (D.A.W.) and a Canadian Liver
   Foundation operating grant (2017). D.A.W. holds an Ontario Ministry of
   Innovation Early Researcher Award.
CR Allaire JM, 2018, TRENDS IMMUNOL, V39, P677, DOI 10.1016/j.it.2018.04.002
   Anhe FF, 2020, NAT METAB, V2, P233, DOI 10.1038/s42255-020-0178-9
   Atarashi K, 2015, CELL, V163, P367, DOI 10.1016/j.cell.2015.08.058
   Bando JK, 2020, J EXP MED, V217, DOI 10.1084/jem.20191520
   Baumann-Dudenhoeffer AM, 2018, NAT MED, V24, P1822, DOI 10.1038/s41591-018-0216-2
   Bokulich NA, 2016, SCI TRANSL MED, V8, DOI 10.1126/scitranslmed.aad7121
   Brestoff JR, 2015, NATURE, V519, P242, DOI 10.1038/nature14115
   Bunker JJ, 2018, IMMUNITY, V49, P211, DOI 10.1016/j.immuni.2018.08.011
   Caesar R, 2015, CELL METAB, V22, P658, DOI 10.1016/j.cmet.2015.07.026
   Cancello R, 2005, DIABETES, V54, P2277, DOI 10.2337/diabetes.54.8.2277
   Canfora EE, 2019, NAT REV ENDOCRINOL, V15, P261, DOI 10.1038/s41574-019-0156-z
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   Cao W, 2017, IMMUNITY, V47, P1182, DOI 10.1016/j.immuni.2017.11.012
   Catanzaro JR, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-49923-2
   Chen HW, 2019, CELL, V177, P1217, DOI 10.1016/j.cell.2019.03.036
   Chen ZY, 2014, J CLIN INVEST, V124, P3391, DOI 10.1172/JCI72517
   Chevalier C, 2015, CELL, V163, P1360, DOI 10.1016/j.cell.2015.11.004
   Constantinides MG, 2019, SCIENCE, V366, P445, DOI 10.1126/science.aax6624
   de Guinoa JS, 2018, EMBO J, V37, DOI 10.15252/embj.201797537
   De Vadder F, 2016, CELL METAB, V24, P151, DOI 10.1016/j.cmet.2016.06.013
   Deczkowska A, 2020, CELL, V181, P1207, DOI 10.1016/j.cell.2020.05.003
   den Besten G, 2015, DIABETES, V64, P2398, DOI 10.2337/db14-1213
   Depommier C, 2019, NAT MED, V25, P1096, DOI 10.1038/s41591-019-0495-2
   Deschasaux M, 2018, NAT MED, V24, P1526, DOI 10.1038/s41591-018-0160-1
   DO MH, 2018, NUTRIENTS, V10
   Duan FF, 2015, DIABETES, V64, P1794, DOI 10.2337/db14-0635
   Everard A, 2014, NAT COMMUN, V5, DOI 10.1038/ncomms6648
   Fabbiano S, 2018, CELL METAB, V28, P907, DOI 10.1016/j.cmet.2018.08.005
   Fadlallah J, 2018, SCI TRANSL MED, V10, DOI 10.1126/scitranslmed.aan1217
   Fang S, 2015, NAT MED, V21, P159, DOI 10.1038/nm.3760
   Fei N, 2013, ISME J, V7, P880, DOI 10.1038/ismej.2012.153
   Feng T, 2011, MUCOSAL IMMUNOL, V4, P15, DOI 10.1038/mi.2010.60
   Fritz JH, 2012, NATURE, V481, P199, DOI 10.1038/nature10698
   Furusawa Y, 2013, NATURE, V504, P446, DOI 10.1038/nature12721
   Gagnon J, 2015, ENDOCRINOLOGY, V156, P3950, DOI 10.1210/en.2015-1361
   Garidou L, 2015, CELL METAB, V22, P100, DOI 10.1016/j.cmet.2015.06.001
   Ghazarian M, 2017, SCI IMMUNOL, V2, DOI 10.1126/sciimmunol.aai7616
   Gleeson M, 2011, NAT REV IMMUNOL, V11, P607, DOI 10.1038/nri3041
   Goettel JA, 2016, CELL REP, V17, P1318, DOI 10.1016/j.celrep.2016.09.082
   Gonzalez-Muniesa P, 2017, NAT REV DIS PRIMERS, V3, DOI 10.1038/nrdp.2017.34
   Greer RL, 2016, NAT COMMUN, V7, DOI 10.1038/ncomms13329
   Hang SY, 2019, NATURE, V576, P143, DOI 10.1038/s41586-019-1785-z
   Hanna MK, 2000, JPEN-PARENTER ENTER, V24, P261, DOI 10.1177/0148607100024005261
   Hasnain SZ, 2013, GASTROENTEROLOGY, V144, P357, DOI 10.1053/j.gastro.2012.10.043
   He S, 2019, NATURE, V566, P115, DOI 10.1038/s41586-018-0849-9
   He Y, 2018, NAT MED, V24, P1532, DOI 10.1038/s41591-018-0164-x
   Hong CP, 2017, GASTROENTEROLOGY, V152, P1998, DOI 10.1053/j.gastro.2017.02.016
   Imajo K, 2012, CELL METAB, V16, P44, DOI 10.1016/j.cmet.2012.05.012
   Iyer SS, 2018, CELL, V173, P1123, DOI 10.1016/j.cell.2018.04.037
   Jarret A, 2020, CELL, V180, P50, DOI 10.1016/j.cell.2019.12.016
   Jeuken A, 2003, J AGR FOOD CHEM, V51, P5478, DOI 10.1021/jf030252u
   Jia W, 2018, NAT REV GASTRO HEPAT, V15, P111, DOI 10.1038/nrgastro.2017.119
   Jiang CT, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms10166
   Jing YY, 2018, MOL CELL ENDOCRINOL, V461, P256, DOI 10.1016/j.mce.2017.09.025
   Jordan S, 2019, CELL, V178, P1102, DOI 10.1016/j.cell.2019.07.050
   Kawano Y, 2016, CELL METAB, V24, P295, DOI 10.1016/j.cmet.2016.07.009
   Kern T, 2020, INT J OBESITY, V44, P125, DOI 10.1038/s41366-019-0440-y
   Khan S, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.00267
   Khan S, 2020, SCI TRANSL MED, V12, DOI 10.1126/scitranslmed.aay6218
   Kim M, 2016, CELL HOST MICROBE, V20, P202, DOI 10.1016/j.chom.2016.07.001
   Kiner E, 2021, NAT IMMUNOL, V22, P216, DOI 10.1038/s41590-020-00836-7
   Kinnebrew MA, 2012, IMMUNOL REV, V245, P113, DOI 10.1111/j.1600-065X.2011.01081.x
   Koeth RA, 2013, NAT MED, V19, P576, DOI 10.1038/nm.3145
   Koh A, 2018, CELL, V175, P947, DOI 10.1016/j.cell.2018.09.055
   Kopp W, 2019, DIABET METAB SYND OB, V12, P2221, DOI 10.2147/DMSO.S216791
   Koscso B, 2020, SCI IMMUNOL, V5, DOI 10.1126/sciimmunol.aax0062
   Krisko TI, 2020, CELL METAB, V31, P592, DOI 10.1016/j.cmet.2020.01.012
   Le Chatelier E, 2013, NATURE, V500, P541, DOI 10.1038/nature12506
   Leon-Ponte M, 2007, BLOOD, V109, P3139, DOI 10.1182/blood-2006-10-052787
   Li BG, 2019, CELL REP, V26, P2720, DOI 10.1016/j.celrep.2019.02.015
   Li YM, 2018, FRONT IMMUNOL, V9, DOI 10.3389/fimmu.2018.01994
   Lin YH, 2019, INT J OBESITY, V43, P2407, DOI 10.1038/s41366-019-0340-1
   Loomba R, 2017, CELL METAB, V25, P1054, DOI 10.1016/j.cmet.2017.04.001
   Luck H, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-11370-y
   Luck H, 2015, CELL METAB, V21, P527, DOI 10.1016/j.cmet.2015.03.001
   Martinez-Lopez M, 2019, IMMUNITY, V50, P446, DOI 10.1016/j.immuni.2018.12.020
   Massier L, 2020, GUT, V69, P1796, DOI 10.1136/gutjnl-2019-320118
   Mazmanian SK, 2005, CELL, V122, P107, DOI 10.1016/j.cell.2005.05.007
   Mazzini E, 2014, IMMUNITY, V40, P248, DOI 10.1016/j.immuni.2013.12.012
   Miyamoto J, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-11978-0
   Miyamoto S, 2012, DIABETES, V61, P897, DOI 10.2337/db11-0402
   Monteiro-Sepulveda M, 2015, CELL METAB, V22, P113, DOI 10.1016/j.cmet.2015.05.020
   Morita N, 2019, NATURE, V566, P110, DOI 10.1038/s41586-019-0884-1
   Moro-Sibilot L, 2016, GASTROENTEROLOGY, V151, P311, DOI 10.1053/j.gastro.2016.04.014
   Mortha A, 2014, SCIENCE, V343, P1477, DOI 10.1126/science.1249288
   Morton AM, 2014, P NATL ACAD SCI USA, V111, P6696, DOI 10.1073/pnas.1405634111
   Natividad JM, 2018, CELL METAB, V28, P737, DOI 10.1016/j.cmet.2018.07.001
   Natividad JM, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-018-05249-7
   Neumann C, 2019, NAT IMMUNOL, V20, P471, DOI 10.1038/s41590-019-0316-2
   Olin A, 2018, CELL, V174, P1277, DOI 10.1016/j.cell.2018.06.045
   Omenetti S, 2019, IMMUNITY, V51, P77, DOI 10.1016/j.immuni.2019.05.004
   Panigrahi P, 2017, NATURE, V548, P407, DOI 10.1038/nature23480
   Petersen C, 2019, SCIENCE, V365, P340, DOI 10.1126/science.aat9351
   Plovier H, 2017, NAT MED, V23, P107, DOI 10.1038/nm.4236
   Pomie C, 2016, MOL METAB, V5, P392, DOI 10.1016/j.molmet.2016.03.004
   Qiu J, 2013, IMMUNITY, V39, P386, DOI 10.1016/j.immuni.2013.08.002
   Qiu YF, 2014, CELL, V157, P1292, DOI 10.1016/j.cell.2014.03.066
   Ridaura VK, 2013, SCIENCE, V341, P1079, DOI 10.1126/science.1241214
   Robertson SJ, 2019, CELL REP, V27, P1910, DOI 10.1016/j.celrep.2019.04.023
   Rojas OL, 2019, CELL, V176, P610, DOI 10.1016/j.cell.2018.11.035
   Rondanelli M, 2017, GUT MICROBES, V8, P521, DOI 10.1080/19490976.2017.1345414
   Ross AC, 2011, VITAM HORM, V86, P103, DOI 10.1016/B978-0-12-386960-9.00005-8
   Rubic T, 2008, NAT IMMUNOL, V9, P1261, DOI 10.1038/ni.1657
   Samuel BS, 2008, P NATL ACAD SCI USA, V105, P16767, DOI 10.1073/pnas.0808567105
   Sasaki T, 2019, CELL REP, V28, P202, DOI 10.1016/j.celrep.2019.06.016
   Schiering C, 2017, NATURE, V542, P242, DOI 10.1038/nature21080
   Schroeder BO, 2018, CELL HOST MICROBE, V23, P27, DOI 10.1016/j.chom.2017.11.004
   Schugar RC, 2017, CELL REP, V19, P2451, DOI 10.1016/j.celrep.2017.05.077
   Schuster S, 2018, NAT REV GASTRO HEPAT, V15, P349, DOI 10.1038/s41575-018-0009-6
   Schwiertz A, 2010, OBESITY, V18, P190, DOI 10.1038/oby.2009.167
   Scott NA, 2018, SCI TRANSL MED, V10, DOI 10.1126/scitranslmed.aao4755
   Sefik E, 2015, SCIENCE, V349, P993, DOI 10.1126/science.aaa9420
   Shalapour S, 2017, NATURE, V551, P340, DOI 10.1038/nature24302
   Shao Y, 2019, NATURE, V574, P117, DOI 10.1038/s41586-019-1560-1
   Shaw TN, 2018, J EXP MED, V215, P1507, DOI 10.1084/jem.20180019
   Shen L, 2015, DIABETES, V64, P593, DOI 10.2337/db14-0554
   Shin NR, 2015, TRENDS BIOTECHNOL, V33, P496, DOI 10.1016/j.tibtech.2015.06.011
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Smith PM, 2013, SCIENCE, V341, P569, DOI 10.1126/science.1241165
   Song XY, 2020, NATURE, V577, P410, DOI 10.1038/s41586-019-1865-0
   Sookoian S, 2020, GUT, V69, P1483, DOI 10.1136/gutjnl-2019-318811
   Stagg AJ, 2018, FRONT IMMUNOL, V9, DOI 10.3389/fimmu.2018.02883
   Steidler L, 2000, SCIENCE, V289, P1352, DOI 10.1126/science.289.5483.1352
   Stein RR, 2018, ELIFE, V7, DOI 10.7554/eLife.30916
   Suarez-Zamorano N, 2015, NAT MED, V21, P1497, DOI 10.1038/nm.3994
   Suez J, 2018, CELL, V174, P1406, DOI 10.1016/j.cell.2018.08.047
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Thaiss CA, 2018, SCIENCE, V359, P1376, DOI 10.1126/science.aar3318
   Tilg H, 2020, NAT REV IMMUNOL, V20, P40, DOI 10.1038/s41577-019-0198-4
   Toubal A, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-17307-0
   Tran HQ, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-13538-y
   Tremaroli V, 2015, CELL METAB, V22, P228, DOI 10.1016/j.cmet.2015.07.009
   Tsai S, 2019, CELL METAB, V29, P787, DOI 10.1016/j.cmet.2019.03.002
   Tsai S, 2018, CELL METAB, V28, P922, DOI 10.1016/j.cmet.2018.08.003
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Vaidyanathan B, 2017, J EXP MED, V214, P197, DOI 10.1084/jem.20160789
   Vangay P, 2018, CELL, V175, P962, DOI 10.1016/j.cell.2018.10.029
   Varelias A, 2018, J CLIN INVEST, V128, P1919, DOI 10.1172/JCI91646
   Vavassori P, 2009, J IMMUNOL, V183, P6251, DOI 10.4049/jimmunol.0803978
   Wahlstrom A, 2016, CELL METAB, V24, P41, DOI 10.1016/j.cmet.2016.05.005
   Wang K, 2019, CELL REP, V26, P222, DOI 10.1016/j.celrep.2018.12.028
   Wang XT, 2014, NATURE, V514, P237, DOI 10.1038/nature13564
   Winer DA, 2017, J CLIN INVEST, V127, P33, DOI 10.1172/JCI88879
   Winer DA, 2016, CELL METAB, V23, P413, DOI 10.1016/j.cmet.2016.01.003
   Winer DA, 2011, NAT MED, V17, P610, DOI 10.1038/nm.2353
   Winter SE, 2013, SCIENCE, V339, P708, DOI 10.1126/science.1232467
   Wu W, 2017, MUCOSAL IMMUNOL, V10, P946, DOI 10.1038/mi.2016.114
   Xu M, 2018, NATURE, V554, P373, DOI 10.1038/nature25500
   Xu YH, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0117081
   Yudanin NA, 2019, IMMUNITY, V50, P505, DOI 10.1016/j.immuni.2019.01.012
   Yusta B, 2015, DIABETES, V64, P2537, DOI 10.2337/db14-1577
   Zeevi D, 2015, CELL, V163, P1079, DOI 10.1016/j.cell.2015.11.001
   Zhang JG, 2014, INT IMMUNOPHARMACOL, V20, P307, DOI 10.1016/j.intimp.2014.03.013
   Zhao LP, 2018, SCIENCE, V359, P1151, DOI 10.1126/science.aao5774
   Zmora N, 2018, CELL, V174, P1388, DOI 10.1016/j.cell.2018.08.041
NR 155
TC 35
Z9 38
U1 8
U2 45
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
EI 2041-1723
J9 NAT COMMUN
JI Nat. Commun.
PD MAY 10
PY 2021
VL 12
IS 1
AR 2598
DI 10.1038/s41467-021-22727-7
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA UD6HG
UT WOS:000687305500003
PM 33972511
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Salazar, J
   Angarita, L
   Morillo, V
   Navarro, C
   Martinez, MS
   Chacin, M
   Torres, W
   Rajotia, A
   Rojas, M
   Cano, C
   Anez, R
   Rojas, J
   Bermudez, V
AF Salazar, Juan
   Angarita, Lisse
   Morillo, Valery
   Navarro, Carla
   Martinez, Maria Sofia
   Chacin, Maricarmen
   Torres, Wheeler
   Rajotia, Arush
   Rojas, Milagros
   Cano, Climaco
   Anez, Roberto
   Rojas, Joselyn
   Bermudez, Valmore
TI Microbiota and Diabetes Mellitus: Role of Lipid Mediators
SO NUTRIENTS
LA English
DT Review
DE diabetes; inflammation; microbiota; dysbiosis; lipopolysaccharides;
   short-chain fatty acids
ID CHAIN FATTY-ACIDS; TIGHT JUNCTION PERMEABILITY; DIET-INDUCED OBESITY;
   GUT MICROBIOTA; INSULIN-RESISTANCE; BETA-CELL; METABOLIC SYNDROME;
   T-CELLS; IN-VIVO; INFLAMMATION
AB Diabetes Mellitus (DM) is an inflammatory clinical entity with different mechanisms involved in its physiopathology. Among these, the dysfunction of the gut microbiota stands out. Currently, it is understood that lipid products derived from the gut microbiota are capable of interacting with cells from the immune system and have an immunomodulatory effect. In the presence of dysbiosis, the concentration of lipopolysaccharides (LPS) increases, favoring damage to the intestinal barrier. Furthermore, a pro-inflammatory environment prevails, and a state of insulin resistance and hyperglycemia is present. Conversely, during eubiosis, the production of short-chain fatty acids (SCFA) is fundamental for the maintenance of the integrity of the intestinal barrier as well as for immunogenic tolerance and appetite/satiety perception, leading to a protective effect. Additionally, it has been demonstrated that alterations or dysregulation of the gut microbiota can be reversed by modifying the eating habits of the patients or with the administration of prebiotics, probiotics, and symbiotics. Similarly, different studies have demonstrated that drugs like Metformin are capable of modifying the composition of the gut microbiota, promoting changes in the biosynthesis of LPS, and the metabolism of SCFA.
C1 [Salazar, Juan; Morillo, Valery; Navarro, Carla; Martinez, Maria Sofia; Torres, Wheeler; Rojas, Milagros; Cano, Climaco] Univ Zulia, Sch Med, Endocrine & Metab Dis Res Ctr, Maracaibo 4004, Venezuela.
   [Angarita, Lisse] Univ Andres Bello, Fac Med, Escuela Nutr & Dietet, Sede Concepcion 4260000, Chile.
   [Chacin, Maricarmen; Bermudez, Valmore] Univ Simon Bolivar, Fac Ciencias Salud, Barranquilla 080001, Colombia.
   [Rajotia, Arush] Sharma Post Grad Inst Med Sci, Rohtak 122001, Haryana, India.
   [Anez, Roberto] Hosp Gen Univ Gregorio Maranon, Dept Endocrinol & Nutr, Madrid 28009, Spain.
   [Rojas, Joselyn] Harvard Med Sch, Brigham & Womens Hosp, Div Pulm & Crit Care Med, Boston, MA 02115 USA.
C3 Universidad Andres Bello; Pt. B.D. Sharma Post Graduate Institute of
   Medical Sciences (PGIMS), Rohtak; General University Gregorio Maranon
   Hospital; Harvard University; Brigham & Women's Hospital; Harvard
   Medical School
RP Salazar, J (通讯作者)，Univ Zulia, Sch Med, Endocrine & Metab Dis Res Ctr, Maracaibo 4004, Venezuela.
EM juanjsv18@hotmail.com; lisse.angarita@unab.cl;
   valerycmb@fmed.luz.edu.ve; Cpnm18@fmed.luz.edu.ve;
   mariasofia876@gmail.com; m.chacin@unisimonbolivar.edu.co;
   wtorres@fmed.luz.edu.ve; arush.rajotia6@gmail.com;
   milagrosrojascaldera@gmail.com; climacoc@hotmail.com;
   Roberto_anez89@hotmail.com; jrojasquintero@bwh.harvard.edu;
   v.bermudez@unisimonbolivar.edu.co
RI Bermudez, Valmore/E-3517-2018; Bermudez, Valmore/K-4721-2019; Bermudez,
   Valmore/HLH-6291-2023
OI Bermudez, Valmore/0000-0003-1880-8887; Bermudez,
   Valmore/0000-0003-1880-8887; Bermudez, Valmore/0000-0003-1880-8887;
   Rojas-Quintero, Joselyn Joanna/0000-0003-4994-075X; Chacin,
   Maricarmen/0000-0002-5208-9401; Martinez Cruz, Maria
   Sofia/0000-0002-3419-0960; Navarro, Carla/0000-0002-1321-9568; Rajotia,
   Arush/0000-0002-9299-2910; Angarita, Lisse/0000-0001-7860-5112; Rojas,
   Milagros/0000-0003-2764-8846
FU Consejo de Desarrollo Cientifico, Humanistico y Tecnologico (CONDES)
   [CC-0437-10-21-09-10]; University of Zulia; Fundacite-Zulia
   [FZ-0058-2007]
FX This work was supported by Research Grant No. CC-0437-10-21-09-10 from
   Consejo de Desarrollo Cientifico, Humanistico y Tecnologico (CONDES),
   University of Zulia, and Research Grant no. FZ-0058-2007 from
   Fundacite-Zulia.
CR Abdel-Moneim A, 2018, BIOMED PHARMACOTHER, V101, P287, DOI 10.1016/j.biopha.2018.02.103
   Ahmad R, 2017, IMMUN INFLAMM DIS, V5, P318, DOI 10.1002/iid3.170
   Alfa Michelle J, 2017, Front Med (Lausanne), V4, P260, DOI 10.3389/fmed.2017.00260
   Alkanani AK, 2015, DIABETES, V64, P3510, DOI 10.2337/db14-1847
   Amyot J, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0036200
   Asemi Z, 2014, CLIN NUTR, V33, P198, DOI 10.1016/j.clnu.2013.05.015
   Astakhova L, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0154102
   Balakumar M, 2018, EUR J NUTR, V57, P279, DOI 10.1007/s00394-016-1317-7
   Baratieri T., 2014, CIENC INNOV SALUD, V2, DOI [10.17081/innosa.2.1.69, DOI 10.17081/INNOSA.2.1.69]
   Baxter NT, 2019, MSPHERE, V4, DOI [10.1128/mSphere.00528-18, 10.1128/msphere.00528-18]
   Bermudez V, 2016, J DIABETES METAB, V7, DOI 10.4172/2155-6156.1000683
   Biagi E, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0010667
   Bjerg AT, 2014, APPETITE, V82, P111, DOI 10.1016/j.appet.2014.07.016
   Bolivar Gonzalez S., 2015, CIENC INNOV SALUD, V3, DOI [10.17081/innosa.3.1.239, DOI 10.17081/INNOSA.3.1.239]
   BONORA E, 1984, CURR MED RES OPIN, V9, P47, DOI 10.1185/03007998409109558
   Brown K, 2016, ISME J, V10, P321, DOI 10.1038/ismej.2015.114
   Bryrup T, 2019, DIABETOLOGIA, V62, P1024, DOI 10.1007/s00125-019-4848-7
   Burcelin R, 2016, MOL METAB, V5, P771, DOI 10.1016/j.molmet.2016.05.016
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Cao J, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-00163-w
   Carding Simon, 2015, Microbial Ecology in Health and Disease, V26, P26191, DOI 10.3402/mehd.v26.26191
   Duran ALC, 2018, REV LATINOAM HIPERTE, V13, P400
   Cavallari JF, 2016, GUT MICROBES, V7, P82, DOI 10.1080/19490976.2015.1127481
   Chan C, 2016, SCI REP-UK, V6, DOI 10.1038/srep37627
   Chen JJ, 2011, EXP BIOL MED, V236, P823, DOI 10.1258/ebm.2011.010399
   Chun E, 2019, IMMUNITY, V51, P871, DOI 10.1016/j.immuni.2019.09.014
   Clarke SF, 2014, GUT, V63, P1913, DOI 10.1136/gutjnl-2013-306541
   Cox MA, 2009, WORLD J GASTROENTERO, V15, P5549, DOI 10.3748/wjg.15.5549
   Davila L.A, 2018, DIABETES FOOD PLAN
   De La Cruz V.J.A., 2017, CIENC INNOV SALUD BA, V4, P1, DOI [10.17081/innosa.4.2.2870, DOI 10.17081/INNOSA.4.2.2870]
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   De Vadder F, 2014, CELL, V156, P84, DOI 10.1016/j.cell.2013.12.016
   DeFronzo RA, 2009, DIABETES, V58, P773, DOI 10.2337/db09-9028
   Duranti S, 2019, ENVIRON MICROBIOL, V21, P3683, DOI 10.1111/1462-2920.14705
   Ebrahimi ZS, 2017, J DIABETES METAB DIS, V16, DOI 10.1186/s40200-017-0304-8
   Endesfelder D, 2016, MICROBIOME, V4, DOI 10.1186/s40168-016-0163-4
   Endesfelder D, 2014, DIABETES, V63, P2006, DOI 10.2337/db13-1676
   Esser N, 2014, DIABETES RES CLIN PR, V105, P141, DOI 10.1016/j.diabres.2014.04.006
   Everard A, 2014, MBIO, V5, DOI 10.1128/mBio.01011-14
   Faneite Antique D.P., 2020, GAC MED CARACAS, V123, P94
   Fang S, 2015, NAT MED, V21, P159, DOI 10.1038/nm.3760
   Ferreira A., 2018, BIOCH HLTH BENEFITS, DOI DOI 10.1016/j.coph.2013.08.006
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Garcia P.O., 2020, GAC MED CARACAS, V120, P107
   Garidou L, 2015, CELL METAB, V22, P100, DOI 10.1016/j.cmet.2015.06.001
   Gomes JMG, 2017, METABOLISM, V68, P133, DOI 10.1016/j.metabol.2016.12.009
   Ghosh SS, 2020, J ENDOCR SOC, V4, DOI 10.1210/jendso/bvz039
   Gonzalez C.M.C., 2020, ARCH VENEZ FARMACOL, V39, P126
   Grasset E, 2017, CELL METAB, V25, P1075, DOI 10.1016/j.cmet.2017.04.013
   Gu YY, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-01682-2
   Guo SH, 2015, J IMMUNOL, V195, P4999, DOI 10.4049/jimmunol.1402598
   Guo SH, 2013, AM J PATHOL, V182, P375, DOI 10.1016/j.ajpath.2012.10.014
   Gurung M, 2020, EBIOMEDICINE, V51, DOI 10.1016/j.ebiom.2019.11.051
   Heianza Y, 2019, GUT, V68, P263, DOI 10.1136/gutjnl-2018-316155
   Herder C, 2016, EUR J ENDOCRINOL, V175, P367, DOI 10.1530/EJE-16-0528
   Hernandez MAG, 2019, NUTRIENTS, V11, DOI 10.3390/nu11081943
   Hill CJ, 2017, MICROBIOME, V5, DOI 10.1186/s40168-016-0213-y
   Huang XJ, 2019, J DIABETES INVEST, V10, P1438, DOI 10.1111/jdi.13056
   IDF, 2015, IDF DIABETES ATLAS, DOI DOI 10.1214/AOMS/1177699147
   Jandhyala SM, 2017, SCI REP-UK, V7, DOI 10.1038/srep43640
   Jeffery IB, 2016, ISME J, V10, P170, DOI 10.1038/ismej.2015.88
   Karczewski J, 2010, AM J PHYSIOL-GASTR L, V298, pG851, DOI 10.1152/ajpgi.00327.2009
   Kassaian N, 2017, TRIALS, V18, DOI 10.1186/s13063-017-1885-8
   Kelder T, 2014, NUTR DIABETES, V4, DOI 10.1038/nutd.2014.18
   Kellow NJ, 2014, BMC ENDOCR DISORD, V14, DOI 10.1186/1472-6823-14-55
   Khondkaryan L, 2018, INT J INFLAMM, V2018, DOI 10.1155/2018/2157434
   Kim CH, 2018, CELL MOL IMMUNOL, V15, P88, DOI 10.1038/cmi.2017.57
   Kim Chang H, 2014, Immune Netw, V14, P277, DOI 10.4110/in.2014.14.6.277
   Kimura I, 2020, PHYSIOL REV, V100, P171, DOI 10.1152/physrev.00041.2018
   Lam YY, 2015, OBESITY, V23, P1429, DOI 10.1002/oby.21122
   Larasati RA, 2019, BIOMEDICINES, V7, DOI 10.3390/biomedicines7040074
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Lee SU, 2013, BIOL PHARM BULL, V36, P1754
   Li M, 2018, EUR J PHARMACOL, V831, P52, DOI 10.1016/j.ejphar.2018.05.003
   Magne F, 2020, NUTRIENTS, V12, DOI 10.3390/nu12051474
   Marti JM, 2017, MSYSTEMS, V2, DOI 10.1128/mSystems.00144-16
   Mariat D, 2009, BMC MICROBIOL, V9, DOI 10.1186/1471-2180-9-123
   Marino E, 2017, NAT IMMUNOL, V18, P552, DOI 10.1038/ni.3713
   Matheus VA, 2017, EXP BIOL MED, V242, P1214, DOI 10.1177/1535370217708188
   Roman-Pintos LM, 2016, J DIABETES RES, V2016, DOI 10.1155/2016/3425617
   Ministery of Health Bolivarian Republic of Venezuela, 2011, AN MORB
   Miranda P.J.P., 2019, ARCH VENEZ FARMACOL, V38, P234
   Mobini R, 2017, DIABETES OBES METAB, V19, P579, DOI 10.1111/dom.12861
   Morales J, 2018, REV LATINOAM HIPERTE, V13, P49
   Morales P, 2016, CLIN TRANSL GASTROEN, V7, DOI 10.1038/ctg.2016.20
   Moreira GV, 2018, J NUTR BIOCHEM, V62, P143, DOI 10.1016/j.jnutbio.2018.07.009
   Murri M, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-46
   Myhrstad MCW, 2020, NUTRIENTS, V12, DOI 10.3390/nu12030859
   Naito E, 2011, J APPL MICROBIOL, V110, P650, DOI 10.1111/j.1365-2672.2010.04922.x
   Napolitano A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100778
   Odegaard AO, 2016, CARDIOVASC DIABETOL, V15, DOI 10.1186/s12933-016-0369-6
   Palacios T, 2017, TRIALS, V18, DOI 10.1186/s13063-016-1762-x
   Pathak P, 2018, HEPATOLOGY, V68, P1574, DOI 10.1002/hep.29857
   Pedersen C, 2016, BRIT J NUTR, V116, P1869, DOI 10.1017/S0007114516004086
   Peng J, 2014, J AUTOIMMUN, V53, P85, DOI 10.1016/j.jaut.2014.03.005
   Perry RJ, 2016, NATURE, V534, P213, DOI 10.1038/nature18309
   Pomie C, 2016, MOL METAB, V5, P392, DOI 10.1016/j.molmet.2016.03.004
   Pouvreau C, 2018, J INFLAMM RES, V11, P61, DOI 10.2147/JIR.S148911
   Puddu Alessandra, 2014, Mediators Inflamm, V2014, P162021, DOI 10.1155/2014/162021
   Rahat-Rozenbloom S, 2017, EUR J CLIN NUTR, V71, P953, DOI 10.1038/ejcn.2016.249
   Ratajczak W, 2019, ACTA BIOCHIM POL, V66, P1, DOI 10.18388/abp.2018_2648
   Remely M, 2016, ENDOCR METAB IMMUNE, V16, P99, DOI 10.2174/1871530316666160831093813
   Remely M, 2014, GENE, V537, P85, DOI 10.1016/j.gene.2013.11.081
   Ridlon JM, 2016, GUT MICROBES, V7, P22, DOI 10.1080/19490976.2015.1127483
   Nieves RRR, 2019, REV LATINOAM HIPERTE, V14, P638
   Rohr MW, 2020, ADV NUTR, V11, P77, DOI 10.1093/advances/nmz061
   Rojas J, 2018, J DIABETES RES, V2018, DOI 10.1155/2018/9601801
   Romero G., 2016, GEN, V70, P64
   Roohi A, 2014, BIOMED RES INT, V2014, DOI 10.1155/2014/718946
   Ruiz L, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.02345
   Schwartz SS, 2016, DIABETES CARE, V39, P179, DOI 10.2337/dc15-1585
   Sharma P, 2016, INT J PREVENTIVE MED, V7, DOI 10.4103/2008-7802.188870
   Shen TCD, 2017, NESTLE NUTR WORKS SE, V88, P117, DOI 10.1159/000455220
   Sigurdardottir S, 2019, CELL IMMUNOL, V341, DOI 10.1016/j.cellimm.2019.04.009
   Sikalidis AK, 2020, BIOMEDICINES, V8, DOI 10.3390/biomedicines8010008
   Smith BJ, 2019, BMC MICROBIOL, V19, DOI 10.1186/s12866-019-1494-7
   Song MJ, 2006, BIOCHEM BIOPH RES CO, V346, P739, DOI 10.1016/j.bbrc.2006.05.170
   Su BL, 2015, J DIABETES, V7, P729, DOI 10.1111/1753-0407.12232
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Topchiy E, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0155030
   Torres Y., 2017, ARCH VENEZ FARMACOL, V36, P144
   Turnbaugh PJ, 2007, NATURE, V449, P804, DOI 10.1038/nature06244
   Valladares R, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0010507
   Vallianou NG, 2019, HORM-INT J ENDOCRINO, V18, P141, DOI 10.1007/s42000-019-00093-w
   VargasRobles D.D., 2020, GAC MED CARACAS, V126, P291
   Vatanen T, 2016, CELL, V165, P842, DOI 10.1016/j.cell.2016.04.007
   Vieira AT, 2016, CLIN TRANSL IMMUNOL, V5, DOI 10.1038/cti.2016.38
   von Scholten BJ, 2016, J DIABETES COMPLICAT, V30, P248, DOI 10.1016/j.jdiacomp.2015.11.005
   Wang L, 2016, SCI REP-UK, V6, DOI [10.1038/srep38380, 10.1038/srep33251, 10.1038/srep20004]
   Wang Zhang, 2018, Endocrinol Diabetes Metab, V1, pe00009, DOI 10.1002/edm2.9
   World Health Organization, 2016, GLOB REP DIAB
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Wu W, 2017, MUCOSAL IMMUNOL, V10, P946, DOI 10.1038/mi.2016.114
   Xu GD, 2018, BIOL PHARM BULL, V41, P1024, DOI 10.1248/bpb.b17-00978
   Xu J, 2015, ISME J, V9, P552, DOI 10.1038/ismej.2014.177
   Yadav H, 2013, J BIOL CHEM, V288, P25088, DOI 10.1074/jbc.M113.452516
   Yan YK, 2019, CARDIOVASC DIABETOL, V18, DOI 10.1186/s12933-019-0913-2
   Yanagibashi T, 2013, IMMUNOBIOLOGY, V218, P645, DOI 10.1016/j.imbio.2012.07.033
   Yang ML, 2017, CELL DEATH DIS, V8, DOI 10.1038/cddis.2017.28
   Yao KC, 2017, MED SCI MONITOR, V23, DOI 10.12659/MSM.902600
   Yap Y.A., 2020, DIETARY SCFAS IMMUNO, DOI [10.1007/5584_2020_515, DOI 10.1007/5584_2020_515]
   Zhang Q, 2018, EXP BIOL MED, V243, P34, DOI 10.1177/1535370217743765
   Zhang XY, 2017, DIABETES THER, V8, P293, DOI 10.1007/s13300-017-0226-y
   Zhao L, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00233
   Zhao LP, 2018, SCIENCE, V359, P1151, DOI 10.1126/science.aao5774
   Zheng JP, 2018, CARBOHYD POLYM, V190, P77, DOI 10.1016/j.carbpol.2018.02.058
   Zozulinska D, 2006, DIABETES RES CLIN PR, V74, pS12, DOI 10.1016/j.diabres.2006.06.007
NR 148
TC 29
Z9 34
U1 3
U2 20
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD OCT
PY 2020
VL 12
IS 10
AR 3039
DI 10.3390/nu12103039
PG 21
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA OL4XC
UT WOS:000585343900001
PM 33023000
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Ouyang, J
   Lin, J
   Isnard, S
   Fombuena, B
   Peng, XR
   Marette, A
   Routy, B
   Messaoudene, M
   Chen, YK
   Routy, JP
AF Ouyang, Jing
   Lin, John
   Isnard, Stephane
   Fombuena, Brandon
   Peng, Xiaorong
   Marette, Andre
   Routy, Bertrand
   Messaoudene, Meriem
   Chen, Yaokai
   Routy, Jean-Pierre
TI The Bacterium Akkermansia muciniphila: A Sentinel for Gut Permeability
   and Its Relevance to HIV-Related Inflammation
SO FRONTIERS IN IMMUNOLOGY
LA English
DT Article
DE Akkermansia muciniphila; epithelial gut damage; inflammation; microbial
   translocation; HIV
ID ANTIRETROVIRAL THERAPY; INTESTINAL MICROBIOTA; DIETARY POLYPHENOLS;
   IMMUNE ACTIVATION; MUCIN; BUTYRATE; CELLS; DYSBIOSIS; METFORMIN;
   RESPONSES
AB Gut dysbiosis, namely dysregulation of the intestinal microbiota, and increased gut permeability lead to enhanced inflammation and are commonly seen in chronic conditions such as obesity and aging. In people living with HIV (PLWH), several lines of evidence suggest that a depletion of gut CD4 T-cells is associated with gut dysbiosis, microbial translocation and systemic inflammation. Antiretroviral therapy (ART) rapidly controls viral replication, which leads to CD4 T-cell recovery and control of the disease. However, gut dysbiosis, epithelial damage and microbial translocation persist despite ART, increasing risk of developing inflammatory non-AIDS comorbidities such as cardiovascular disease, diabetes mellitus, liver steatosis and cancer. In addition to ART, an emerging research priority is to discover strategies to improve the gut microbial composition and intestinal barrier function. Probiotic interventions have been extensively used with controversial benefits in humans. Encouragingly, within the last decade, the intestinal symbiotic bacterium Akkermansia muciniphila has emerged as the "sentinel of the gut." A lower abundance of A. muciniphila has been shown in diabetic and obese people as well as in PLWH. Interventions with high levels of polyphenols such as tea or diets rich in fruit, the antibiotic vancomycin and the antidiabetic drug metformin have been shown to increase A. muciniphila abundance, contributing to improved metabolic function in diabetic and obese individuals. We hypothesize that gut microbiota rich in A. muciniphila can reduce microbial translocation and inflammation, preventing occurrences of non-AIDS comorbidities in PLWH. To this aim, we will discuss the protective effect of A. muciniphila and its potential applications, paving the way toward novel therapeutic strategies to improve gut health in PLWH.
C1 [Ouyang, Jing; Lin, John; Isnard, Stephane; Fombuena, Brandon; Peng, Xiaorong; Routy, Jean-Pierre] McGill Univ, Res Inst, Infect Dis & Immun Global Hlth Program, Hlth Ctr, Montreal, PQ, Canada.
   [Ouyang, Jing; Lin, John; Isnard, Stephane; Fombuena, Brandon; Peng, Xiaorong; Routy, Jean-Pierre] McGill Univ, Hlth Ctr, Chron Viral Illness Serv, Montreal, PQ, Canada.
   [Ouyang, Jing; Chen, Yaokai] Chongqing Publ Hlth Med Ctr, Chongqing, Peoples R China.
   [Fombuena, Brandon] McGill Univ, Dept Microbiol & Immunol, Montreal, PQ, Canada.
   [Peng, Xiaorong] Zhejiang Univ, Collaborat Innovat Ctr Diag & Treatment Infect Di, State Key Lab Diag & Treatment Infect Dis, Natl Clin Res Ctr Infect Dis,Coll Med,Affiliated, Hangzhou, Peoples R China.
   [Marette, Andre] Laval Univ, Dept Med, Fac Med, Cardiol Axis Quebec Heart & Lung Inst, Laval, PQ, Canada.
   [Marette, Andre] Laval Univ, Inst Nutr & Funct Foods, Laval, PQ, Canada.
   [Routy, Bertrand; Messaoudene, Meriem] Ctr Hosp Univ Montreal CRCHUM, Ctr Rech, Montreal, PQ, Canada.
   [Routy, Bertrand] Ctr Hosp Univ Montreal CHUM, Dept Med, Hematol Oncol Div, Montreal, PQ, Canada.
   [Routy, Jean-Pierre] McGill Univ, Div Hematol, Hlth Ctr, Montreal, PQ, Canada.
C3 McGill University; McGill University; McGill University; Collaborative
   Innovation Center for Diagnosis & Treatment of Infectious Diseases;
   Zhejiang University; Laval University; Quebec Heart & Lung Institute;
   Laval University; Universite de Montreal; Universite de Montreal; McGill
   University
RP Routy, JP (通讯作者)，McGill Univ, Res Inst, Infect Dis & Immun Global Hlth Program, Hlth Ctr, Montreal, PQ, Canada.; Routy, JP (通讯作者)，McGill Univ, Hlth Ctr, Chron Viral Illness Serv, Montreal, PQ, Canada.; Chen, YK (通讯作者)，Chongqing Publ Hlth Med Ctr, Chongqing, Peoples R China.; Routy, JP (通讯作者)，McGill Univ, Div Hematol, Hlth Ctr, Montreal, PQ, Canada.
EM yaokaichen@hotmail.com; jean-pierre.routy@mcgill.ca
RI Marette, Andre/E-9342-2013
OI Marette, Andre/0000-0003-3950-5973; Lin, John/0000-0002-2596-969X
FU Canadian Institutes of Health Research (CIHR) [MOP 103230, PTJ 166049];
   Vaccines & Immunotherapy Core of the CIHR Canadian HIV Trials Network
   (CTN) [CTN 257, CTN PT027]; CIHR [HB2-164064]; Chinese National Science
   and Technology Major Project during the 13th FiveYear Plan
   [2018ZX10302104]; CIHR Foundation
FX This work was funded by the Canadian Institutes of Health Research
   (CIHR; grants MOP 103230 and PTJ 166049), the Vaccines & Immunotherapy
   Core of the CIHR Canadian HIV Trials Network (CTN, grant CTN 257 and CTN
   PT027), the CIHR-funded Canadian HIV Cure Enterprise (CanCURE) Team
   Grant HB2-164064, and the Chinese National Science and Technology Major
   Project during the 13th FiveYear Plan (No. 2018ZX10302104). AM holds a
   CIHR/Pfizer Research Chair in the pathogenesis of insulin resistance and
   cardiovascular complications was supported by a CIHR Foundation grant.
CR Adriaanse MPM, 2013, ALIMENT PHARM THER, V37, P482, DOI 10.1111/apt.12194
   Al-Saffar AK, 2017, GASTROENT RES PRACT, V2017, DOI 10.1155/2017/1745918
   Anhe FF, 2019, NAT MED, V25, P1031, DOI 10.1038/s41591-019-0516-1
   Anhe FF, 2019, GUT, V68, P453, DOI 10.1136/gutjnl-2017-315565
   Anhe FF, 2016, GUT MICROBES, V7, P146, DOI 10.1080/19490976.2016.1142036
   Anhe FF, 2015, GUT, V64, P872, DOI 10.1136/gutjnl-2014-307142
   Ansaldo E, 2019, SCIENCE, V364, P1179, DOI 10.1126/science.aaw7479
   Atarashi K, 2011, SCIENCE, V331, P337, DOI 10.1126/science.1198469
   Belzer C, 2017, MBIO, V8, DOI [10.1128/mBio.00770-17, 10.1128/mbio.00770-17]
   Bevins CL, 2011, NAT REV MICROBIOL, V9, P356, DOI 10.1038/nrmicro2546
   Brahe LK, 2015, NUTR DIABETES, V5, DOI 10.1038/nutd.2015.9
   Brenchley JM, 2008, MUCOSAL IMMUNOL, V1, P23, DOI 10.1038/mi.2007.1
   Brenchley JM, 2006, NAT MED, V12, P1365, DOI 10.1038/nm1511
   Brown TT, 2005, ARCH INTERN MED, V165, P1179, DOI 10.1001/archinte.165.10.1179
   Cani PD, 2014, M S-MED SCI, V30, P125, DOI 10.1051/medsci/20143002003
   Ceccarelli G, 2019, EXPERT OPIN BIOL TH, V19, P949, DOI 10.1080/14712598.2019.1638907
   Chelakkot C, 2018, EXP MOL MED, V50, DOI 10.1038/emm.2017.282
   Chen LP, 2014, MEDICINE, V93, DOI 10.1097/MD.0000000000000051
   Cheng J, 2016, ISME J, V10, P1002, DOI 10.1038/ismej.2015.177
   Cheru LT, 2018, OPEN FORUM INFECT DI, V5, DOI 10.1093/ofid/ofy288
   Choi Jeonghyun, 2018, J Lifestyle Med, V8, P1, DOI 10.15280/jlm.2018.8.1.1
   Collado MC, 2007, APPL ENVIRON MICROB, V73, P7767, DOI 10.1128/AEM.01477-07
   Cornejo-Pareja I, 2019, EUR J CLIN NUTR, V72, P26, DOI 10.1038/s41430-018-0306-8
   de Vos WM, 2017, MICROBIOL-SGM, V163, P646, DOI 10.1099/mic.0.000444
   Depommier C, 2019, NAT MED, V25, P1096, DOI 10.1038/s41591-019-0495-2
   Derrien M, 2004, INT J SYST EVOL MICR, V54, P1469, DOI 10.1099/ijs.0.02873-0
   Derrien M, 2008, APPL ENVIRON MICROB, V74, P1646, DOI 10.1128/AEM.01226-07
   Derrien M, 2017, MICROB PATHOGENESIS, V106, P171, DOI 10.1016/j.micpath.2016.02.005
   Derrien M, 2011, FRONT MICROBIOL, V2, DOI 10.3389/fmicb.2011.00166
   Dillon SM, 2017, AIDS, V31, P510, DOI 10.1097/QAD.0000000000001366
   Douek Daniel, 2007, Top HIV Med, V15, P114
   Dubourg G, 2013, INT J ANTIMICROB AG, V41, P149, DOI 10.1016/j.ijantimicag.2012.10.012
   Duffau P, 2018, AIDS, V32, P1651, DOI 10.1097/QAD.0000000000001875
   Estrada V, 2018, EBIOMEDICINE, V38, P17, DOI 10.1016/j.ebiom.2018.11.019
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Everard A, 2011, DIABETES, V60, P2775, DOI 10.2337/db11-0227
   Frank DN, 2011, INFLAMM BOWEL DIS, V17, P179, DOI 10.1002/ibd.21339
   Gogokhia L, 2020, JAIDS-J ACQ IMM DEF, V83, P81, DOI 10.1097/QAI.0000000000002229
   Gonzalez-Hernandez LA, 2019, BMC INFECT DIS, V19, DOI 10.1186/s12879-019-3867-9
   Gopalakrishnan V, 2018, SCIENCE, V359, P97, DOI 10.1126/science.aan4236
   Gurley BJ, 2019, NUTRIENTS, V11, DOI 10.3390/nu11040776
   Hague A, 1996, P NUTR SOC, V55, P937, DOI 10.1079/PNS19960090
   Hanninen A, 2018, GUT, V67, P1445, DOI 10.1136/gutjnl-2017-314508
   Hansen CHF, 2012, DIABETOLOGIA, V55, P2285, DOI 10.1007/s00125-012-2564-7
   Hoenigl M, 2020, CLIN INFECT DIS, V70, P242, DOI 10.1093/cid/ciz215
   Hsu DC, 2016, DRUGS, V76, P533, DOI 10.1007/s40265-016-0546-7
   Huang HL, 2019, J DIGEST DIS, V20, P401, DOI 10.1111/1751-2980.12756
   Huck O, 2020, J CLIN PERIODONTOL, V47, P202, DOI 10.1111/jcpe.13214
   Isnard S, 2020, J INFECT DIS, V221, P110, DOI 10.1093/infdis/jiz423
   Jenabian MA, 2015, J INFECT DIS, V212, P355, DOI 10.1093/infdis/jiv037
   Kang CS, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0076520
   Katiraei S, 2020, MOL NUTR FOOD RES, V64, DOI 10.1002/mnfr.201900732
   Kosciow K, 2020, INT J BIOL MACROMOL, V149, P331, DOI 10.1016/j.ijbiomac.2020.01.246
   Krahn T, 2020, CLIN INFECT DIS, V71, P243, DOI 10.1093/cid/ciz929
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Lawenius L, 2020, AM J PHYSIOL-ENDOC M, V318, pE480, DOI 10.1152/ajpendo.00425.2019
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Li J, 2016, CIRCULATION, V133, P2434, DOI 10.1161/CIRCULATIONAHA.115.019645
   Liu RX, 2017, NAT MED, V23, P859, DOI 10.1038/nm.4358
   Lopez-Siles M, 2012, APPL ENVIRON MICROB, V78, P420, DOI 10.1128/AEM.06858-11
   Madiraju AK, 2018, NAT MED, V24, P1384, DOI 10.1038/s41591-018-0125-4
   Matson V, 2018, SCIENCE, V359, P104, DOI 10.1126/science.aao3290
   McGuckin MA, 2011, NAT REV MICROBIOL, V9, P265, DOI 10.1038/nrmicro2538
   Mehandru S, 2005, J ALLERGY CLIN IMMUN, V116, P419, DOI 10.1016/j.jaci.2005.05.040
   Mehraj V, 2020, CLIN INFECT DIS, V70, P232, DOI 10.1093/cid/ciz212
   Morris A, 2012, JAIDS-J ACQ IMM DEF, V61, P462, DOI 10.1097/QAI.0b013e318271799b
   Mu JZ, 2019, CURR MED RES OPIN, V35, P241, DOI 10.1080/03007995.2018.1470085
   Mutlu EA, 2014, PLOS PATHOG, V10, DOI 10.1371/journal.ppat.1003829
   Naito Y, 2018, J CLIN BIOCHEM NUTR, V63, P33, DOI 10.3164/jcbn.18-57
   Ottman N, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0173004
   Ouwerkerk JP, 2017, BENEF MICROBES, V8, P163, DOI [10.3920/BM2016.0096, 10.3920/bm2016.0096]
   Ouyang J, 2020, AIDS RES THER, V17, DOI 10.1186/s12981-020-00267-2
   Ozkul C, 2019, TURK J GASTROENTEROL, V30, P1030, DOI 10.5152/tjg.2019.19185
   Plovier H, 2017, NAT MED, V23, P107, DOI 10.1038/nm.4236
   Png CW, 2010, AM J GASTROENTEROL, V105, P2420, DOI 10.1038/ajg.2010.281
   Pollak M, 2017, DIABETOLOGIA, V60, P1662, DOI 10.1007/s00125-017-4352-x
   Pryor R, 2019, CELL, V178, P1299, DOI 10.1016/j.cell.2019.08.003
   Rajilic-Stojanovic M, 2013, INFLAMM BOWEL DIS, V19, P481, DOI 10.1097/MIB.0b013e31827fec6d
   Ramendra R, 2020, CLIN INFECT DIS, V71, P1438, DOI 10.1093/cid/ciz1001
   Ramendra R, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.00465
   Rena G, 2017, DIABETOLOGIA, V60, P1577, DOI 10.1007/s00125-017-4342-z
   Reunanen J, 2015, APPL ENVIRON MICROB, V81, P3655, DOI 10.1128/AEM.04050-14
   Rocafort M, 2019, MICROBIOME, V7, DOI 10.1186/s40168-019-0687-5
   Roopchand DE, 2015, DIABETES, V64, P2847, DOI 10.2337/db14-1916
   Routy B, 2018, SCIENCE, V359, P91, DOI 10.1126/science.aan3706
   Routy JP, 2019, BMJ OPEN, V9, DOI 10.1136/bmjopen-2018-028444
   Scharl M, 2009, GASTROENTEROLOGY, V137, P2030, DOI 10.1053/j.gastro.2009.07.078
   Schneeberger M, 2015, SCI REP-UK, V5, DOI 10.1038/srep16643
   Schretter CE, 2020, GUT MICROBES, V11, P245, DOI 10.1080/19490976.2019.1643674
   Segain JP, 2000, GUT, V47, P397, DOI 10.1136/gut.47.3.397
   Serino M, 2018, J MOL BIOL, V430, P581, DOI 10.1016/j.jmb.2018.01.010
   Sessa L, 2019, AIDS, V33, P1001, DOI 10.1097/QAD.0000000000002131
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Thomas S, 2019, J CELL BIOCHEM, V120, P4225, DOI 10.1002/jcb.27716
   Tibbs TN, 2019, MICROB CELL, V6, P324, DOI 10.15698/mic2019.08.685
   Tincati C, 2016, AIDS RES THER, V13, DOI 10.1186/s12981-016-0103-1
   Uribe-Herranz M, 2020, J CLIN INVEST, V130, P466, DOI 10.1172/JCI124332
   Ushiroda C, 2019, J CLIN BIOCHEM NUTR, V65, P34, DOI 10.3164/jcbn.18-116
   Van den Abbeele P, 2013, ISME J, V7, P949, DOI 10.1038/ismej.2012.158
   van der Lugt B, 2019, IMMUN AGEING, V16, DOI 10.1186/s12979-019-0145-z
   van Passel MWJ, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0016876
   Vinolo MAR, 2011, NUTRIENTS, V3, P858, DOI 10.3390/nu3100858
   Vujkovic-Cvijin I, 2019, CURR HIV-AIDS REP, V16, P204, DOI 10.1007/s11904-019-00441-w
   Vujkovic-Cvijin I, 2013, SCI TRANSL MED, V5, DOI 10.1126/scitranslmed.3006438
   Wang HB, 2012, DIGEST DIS SCI, V57, P3126, DOI 10.1007/s10620-012-2259-4
   Wortelboer K, 2019, EBIOMEDICINE, V44, P716, DOI 10.1016/j.ebiom.2019.05.066
   Wu WR, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.01804
   Yassour M, 2016, GENOME MED, V8, DOI 10.1186/s13073-016-0271-6
   Yelin I, 2019, NAT MED, V25, P1728, DOI 10.1038/s41591-019-0626-9
   Zhang PP, 2020, ACTA PHARMACOL SIN, V41, P678, DOI 10.1038/s41401-019-0330-9
   Zheng Y, 2019, J IMMUNOTHER CANCER, V7, DOI 10.1186/s40425-019-0650-9
   Zhou ZY, 2016, ACTA PHARMACOL SIN, V37, P1063, DOI 10.1038/aps.2016.21
   Zicari S, 2019, VIRUSES-BASEL, V11, DOI 10.3390/v11030200
NR 113
TC 54
Z9 56
U1 1
U2 19
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-3224
J9 FRONT IMMUNOL
JI Front. Immunol.
PD APR 9
PY 2020
VL 11
AR 645
DI 10.3389/fimmu.2020.00645
PG 9
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA LJ1II
UT WOS:000529925600001
PM 32328074
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Chen, A
   Park, TY
   Li, KJ
   DeLisi, LE
AF Chen, Anderson
   Park, Tae Yang
   Li, Kevin J.
   DeLisi, Lynn E.
TI Antipsychotics and the microbiota
SO CURRENT OPINION IN PSYCHIATRY
LA English
DT Review
DE antipsychotics; metabolic syndrome; microbiota; schizophrenia
ID GUT MICROBIOME; SCHIZOPHRENIA; HEALTH; DIET; AXIS
AB Purpose of review The gut microbiota has been speculated to underpin metabolic changes associated with chronic antipsychotic use. The change in the gut microbiota can also cause abnormal absorbtion from the gut into the blood stream (leaky gut syndrome) that can lead to inflammatory reactions, and thus, secondary damage to the brain and central nervous system. Our article aims to highlight relevant research on antipsychotic's effect on the microbiota and to point out future directions. Recent findings Antipsychtoic use can result in specific microbiota changes, and it is important to differentiate this from the innate microbiota of the patient. It is important to treat these microbiota changes, as they are correlated with obesity, which is a negative contributor to the cardiovascular health of those suffering with schizophrenia. Ways to prevent antipsychotic-induced side-effects include antibiotic treatment, histamine 3 receptor blockade and metformin use. Given the dearth of current literature, more research is needed, however, to determine, which comes first in people with schizophrenia--an abnormal gut microbiota that elevates one's risk for schizophrenia or psychopharmacologic treatment of schizophrenia leading to secondary microbiota abnormalities or the negative symptoms of schizophrenia leading to obesity and its associated microbiota changes.
C1 [Chen, Anderson; Li, Kevin J.; DeLisi, Lynn E.] Dept Vet Affairs VA Boston Healthcare Syst, Brockton Div, Brockton, MA USA.
   [Chen, Anderson; Li, Kevin J.] Harvard South Shore Psychiat Residency Program, Brockton, MA USA.
   [Chen, Anderson; Li, Kevin J.; DeLisi, Lynn E.] Harvard Med Sch, Boston, MA 02115 USA.
   [Park, Tae Yang] Rutgers Robert Wood Johnson Med Sch, Internal Med Residency Program, New Brunswick, NJ USA.
   [Park, Tae Yang] Cambridge Hosp, Robert Wood Johnson Med Sch, Cambridge, MA 02139 USA.
   [DeLisi, Lynn E.] Cambridge Hosp, Cambridge Hlth Alliance, Cambridge, MA 02139 USA.
C3 Harvard University; Harvard Medical School; Rutgers State University New
   Brunswick; Rutgers State University Medical Center; Harvard University;
   Cambridge Health Alliance; Cambridge Hospital; Rutgers State University
   New Brunswick; Rutgers State University Medical Center; Harvard
   University; Cambridge Health Alliance; Cambridge Hospital
RP Chen, A (通讯作者)，Bld 5,940 Belmont St,116-A7, Brockton, MA 02301 USA.
EM andersonchen2018@gmail.com
CR Athalye-Jape G, 2019, MICROB BIOTECHNOL, V12, P249, DOI 10.1111/1751-7915.13357
   Auquier P, 2007, PHARMACOEPIDEM DR S, V16, P1308, DOI 10.1002/pds.1496
   Bajaj JS, 2012, AM J PHYSIOL-GASTR L, V302, pG168, DOI 10.1152/ajpgi.00190.2011
   Bartosch S, 2004, APPL ENVIRON MICROB, V70, P3575, DOI 10.1128/AEM.70.6.3575-3581.2004
   Bauer PV, 2016, CELL MOL LIFE SCI, V73, P737, DOI 10.1007/s00018-015-2083-z
   Biagi E, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0010667
   Bretler T, 2019, BMC MED, V17, DOI 10.1186/s12916-019-1346-1
   Callaghan RC, 2009, SCHIZOPHR RES, V115, P325, DOI 10.1016/j.schres.2009.07.018
   Claesson MJ, 2012, NATURE, V488, P178, DOI 10.1038/nature11319
   Claesson MJ, 2011, P NATL ACAD SCI USA, V108, P4586, DOI 10.1073/pnas.1000097107
   Cox LM, 2019, BRAIN RES, V1724, DOI 10.1016/j.brainres.2019.146385
   Craig WJ, 2010, NUTR CLIN PRACT, V25, P613, DOI 10.1177/0884533610385707
   Davey KJ, 2013, TRANSL PSYCHIAT, V3, DOI 10.1038/tp.2013.83
   De Filippis Francesca, 2016, Gut, V65, P1812, DOI 10.1136/gutjnl-2015-309957
   Dickerson FB, 2014, PRIM CARE COMPANION, V16
   Kao ACC, 2018, TRANSL PSYCHIAT, V8, DOI 10.1038/s41398-018-0116-8
   Kim S, 2018, GERONTOLOGY, V64, P513, DOI 10.1159/000490615
   Klein SL, 2016, NAT REV IMMUNOL, V16, P626, DOI 10.1038/nri.2016.90
   Konturek PC, 2015, J PHYSIOL PHARMACOL, V66, P483
   Leustean AM, 2018, J DIABETES RES, V2018, DOI 10.1155/2018/5205126
   Lieberman JA, 2005, NEW ENGL J MED, V353, P1209, DOI 10.1056/NEJMoa051688
   Newcomer JW, 2007, JAMA-J AM MED ASSOC, V298, P1794, DOI 10.1001/jama.298.15.1794
   NGUYEN T, 2019, SCHIZOPHR RES
   Okubo R, 2019, J AFFECT DISORDERS, V245, P377, DOI 10.1016/j.jad.2018.11.011
   Ottman N, 2012, FRONT CELL INFECT MI, V2, DOI 10.3389/fcimb.2012.00104
   Ouwehand AC, 2008, FEMS IMMUNOL MED MIC, V53, P18, DOI 10.1111/j.1574-695X.2008.00392.x
   Sainz J, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0215477
   Schwartz S, 2012, GENOME BIOL, V13, DOI 10.1186/gb-2012-13-4-r32
   Silverman MN, 2012, ANN NY ACAD SCI, V1261, P55, DOI 10.1111/j.1749-6632.2012.06633.x
   Tanca A, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-33100-y
   Tomasik J, 2015, BIOMARK INSIGHTS, V10, P47, DOI 10.4137/BMI.S22007
   Vrieze A, 2012, GASTROENTEROLOGY, V143, P913, DOI 10.1053/j.gastro.2012.06.031
   Zheng P, 2016, MOL PSYCHIATR, V21, P786, DOI 10.1038/mp.2016.44
   Zimmer J, 2012, EUR J CLIN NUTR, V66, P53, DOI 10.1038/ejcn.2011.141
NR 34
TC 12
Z9 12
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0951-7367
EI 1473-6578
J9 CURR OPIN PSYCHIATR
JI Curr. Opin. Psychiatr.
PD MAY
PY 2020
VL 33
IS 3
BP 225
EP 230
DI 10.1097/YCO.0000000000000594
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA LE6JQ
UT WOS:000526830300007
PM 32068569
DA 2023-06-08
ER

PT J
AU Cui, HX
   Zhang, LS
   Luo, Y
   Yuan, K
   Huang, ZY
   Guo, Y
AF Cui, Hong-Xin
   Zhang, Ling-Shuai
   Luo, Yang
   Yuan, Ke
   Huang, Zhi-Yong
   Guo, Ying
TI A Purified Anthraquinone-Glycoside Preparation From Rhubarb Ameliorates
   Type 2 Diabetes Mellitus by Modulating the Gut Microbiota and Reducing
   Inflammation
SO FRONTIERS IN MICROBIOLOGY
LA English
DT Article
DE anthraquinone-glucoside; diabetes; gut microbiota; intestinal integrity;
   inflammation
ID INTESTINAL MICROBIOTA; INSULIN-RESISTANCE; MOLECULAR-MECHANISMS; OBESE
   MICE; METABOLISM; SECRETION; EXTRACT; HEALTH
AB Rheum palmatum L. is widely used in traditional Chinese medicine for the treatment of constipation. Here, the therapeutic effects and underlying mechanisms of purified anthraquinone-glycoside preparation from rhubarb (RAGP) on the type 2 diabetes mellitus (T2DM) rats were investigated. After 6 weeks of metformin and RAGP treatment, the weight returned to normal. Fasting blood glucose (FBG), glycated serum protein (GSP), insulin concentration and HOMA-IR index had significantly decreased, and glucagon-like peptide-1 (GLP-1) concentrations had increased. Histological abnormalities in the pancreas and ileum had improved. These effects were associated with enhanced intestinal integrity, thereby reducing the absorption of lipopolysaccharide (LPS) and inflammation. To investigate whether RAGP ameliorated insulin resistance via effects on the gut microbiota, we performed 16s rDNA sequencing of ileal gut contents. This showed an amelioration of gut dysbiosis, with greater abundance of probiotic Lactobacillus and short-chain fatty acid-producing bacteria, and lower abundance of the Lachnospiraceae NK4A136 group and LPS-producing Desulfovibrio. The mechanism of the hypoglycemic effect of RAGP involves regulation of the gut microbiota, activation of the GLP-1/cAMP pathway to ameliorate insulin resistance. Thus, this study provides a theoretical basis for the use of RAGP to treat T2DM, and it may be a novel approach to restore the gut microbiota.
C1 [Cui, Hong-Xin; Zhang, Ling-Shuai] Henan Univ Chinese Med, Coll Pharm, Zhengzhou, Henan, Peoples R China.
   [Cui, Hong-Xin] Collaborat Innovat Ctr Resp Dis Diag & Treatment, Zhengzhou, Henan, Peoples R China.
   [Cui, Hong-Xin] Chinese Med Dev Henan Prov, Zhengzhou, Henan, Peoples R China.
   [Luo, Yang; Yuan, Ke] Zhejiang Agr & Forestry Univ, Jiyang Coll, Zhuji, Peoples R China.
   [Huang, Zhi-Yong; Guo, Ying] Zhejiang Chinese Med Univ, Hangzhou, Zhejiang, Peoples R China.
C3 Henan University of Traditional Chinese Medicine; Zhejiang A&F
   University; Zhejiang Chinese Medical University
RP Yuan, K (通讯作者)，Zhejiang Agr & Forestry Univ, Jiyang Coll, Zhuji, Peoples R China.
EM yuan_ke001@126.com
FU Zhejiang Provincial Science Foundation of China [LY16H280007]
FX This project was supported by the Zhejiang Provincial Science Foundation
   of China (Grant No. LY16H280007).
CR Arvindekar A, 2015, FOOD FUNCT, V6, P2693, DOI [10.1039/c5fo00519a, 10.1039/C5FO00519A]
   Arvindekar AU, 2015, J FOOD SCI TECH MYS, V52, P6574, DOI 10.1007/s13197-015-1814-3
   Azofeifa G, 2016, J FUNCT FOODS, V26, P330, DOI 10.1016/j.jff.2016.08.007
   Brun P, 2007, AM J PHYSIOL-GASTR L, V292, pG518, DOI 10.1152/ajpgi.00024.2006
   Cani PD, 2009, GUT, V58, P1091, DOI 10.1136/gut.2008.165886
   Cao L., 2009, NW PHARM J, V24, P237
   Chassaing B, 2014, TOXICOL PATHOL, V42, P49, DOI 10.1177/0192623313508481
   Chen S. J., 2011, CHIN PRAC MED, V6, P28
   Collado MC, 2007, APPL ENVIRON MICROB, V73, P7767, DOI 10.1128/AEM.01477-07
   Everard A, 2013, BEST PRACT RES CL GA, V27, P73, DOI 10.1016/j.bpg.2013.03.007
   Fava S, 2014, CURR DIABETES REV, V10, P302, DOI 10.2174/1573399810666141030125830
   Fernandes JD, 2016, DIABETES RES CLIN PR, V117, P48, DOI 10.1016/j.diabres.2016.04.016
   Ferrucci L, 2018, NAT REV CARDIOL, V15, P505, DOI 10.1038/s41569-018-0064-2
   Frank A. D., 2014, DIABETES, V63, P1624
   Giugliano D, 1996, DIABETES CARE, V19, P257, DOI 10.2337/diacare.19.3.257
   Gutierrez-Rodelo C, 2017, GAC MED MEX, V153, P214
   Han JL, 2014, WORLD J GASTROENTERO, V20, P17737, DOI 10.3748/wjg.v20.i47.17737
   HATTORI M, 1982, CHEM PHARM BULL, V30, P1338
   He K, 2016, BBA-MOL BASIS DIS, V1862, P1696, DOI 10.1016/j.bbadis.2016.06.006
   Holst JJ, 2011, DIABETES OBES METAB, V13, P89, DOI 10.1111/j.1463-1326.2011.01452.x
   Jiang Y. Y., 2014, MED RECAPITULATE, V20, P3757
   Karlsson F, 2013, DIABETES, V62, P3341, DOI 10.2337/db13-0844
   Kuhre RE, 2015, DIABETES, V64, P370, DOI 10.2337/db14-0807
   Li JW, 2017, J FUNCT FOODS, V38, P399, DOI 10.1016/j.jff.2017.09.031
   Li WL, 2004, J ETHNOPHARMACOL, V92, P1, DOI 10.1016/j.jep.2003.12.031
   [罗培 Luo Pei], 2013, [中药药理与临床, Pharmacology and Clinics of Chinese Materia Medica], V29, P88
   Ma W., 2005, J GUANGDONG MED COLL, V23, P504, DOI [10.1080/01902140902718197, DOI 10.1080/01902140902718197]
   Macfarlane GT, 1997, SCAND J GASTROENTERO, V32, P3, DOI 10.1080/00365521.1997.11720708
   Mahowald MA, 2009, P NATL ACAD SCI USA, V106, P5859, DOI 10.1073/pnas.0901529106
   Mikkelsen KH, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0142352
   Nobaek S, 2000, AM J GASTROENTEROL, V95, P1231
   Park J, 2015, MUCOSAL IMMUNOL, V8, P80, DOI 10.1038/mi.2014.44
   Patterson E, 2016, POSTGRAD MED J, V92, P286, DOI 10.1136/postgradmedj-2015-133285
   Purves GI, 2009, J PHYSIOL-LONDON, V587, P3639, DOI 10.1113/jphysiol.2009.173534
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Qin N, 2014, NATURE, V513, P59, DOI 10.1038/nature13568
   Sato J, 2017, ANN NUTR METAB, V71, P17, DOI 10.1159/000479919
   Sommer F, 2017, NAT REV MICROBIOL, V15, P630, DOI 10.1038/nrmicro.2017.58
   Song R, 2011, BIOMED CHROMATOGR, V25, P417, DOI 10.1002/bmc.1467
   Tangvarasittichai S, 2015, WORLD J DIABETES, V6, P456, DOI 10.4239/wjd.v6.i3.456
   Udayappan SD, 2014, CLIN EXP IMMUNOL, V177, P24, DOI 10.1111/cei.12293
   Van den Abbeele P, 2011, ENVIRON MICROBIOL, V13, P2667, DOI 10.1111/j.1462-2920.2011.02533.x
   Wang M. J., 2017, DIABETES NEW WORLD, V2, P197, DOI [10.16658/j.cnki.1672-4062.2017.04.197, DOI 10.16658/J.CNKI.1672-4062.2017.04.197]
   Wang RuiFeng, 2016, Zhongguo Weishengtaxixue Zazhi / Chinese Journal of Microecology, V28, P21
   Wang Y. L., 2018, PRAC J MED PHARM, V35, P77, DOI [10.1038/nrneph.2017.16, DOI 10.1038/NRNEPH.2017.16]
   Wei XY, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-22094-2
   Wu XK, 2010, CURR MICROBIOL, V61, P69, DOI 10.1007/s00284-010-9582-9
   Xiao SM, 2014, FEMS MICROBIOL ECOL, V87, P357, DOI 10.1111/1574-6941.12228
   Xie G. Z., 2018, SHIJIE HUAREN XIAOHU, V26, P221
   Yan XF, 2016, J DIABETES RES, V2016, DOI 10.1155/2016/2093171
   Yang Y. S., 2015, CHIN J ENDOSCOPY, V8, P798
   [虞夏晖 Yu Xiahui], 2018, [中华中医药杂志, China Journal of Traditional Chinese Medicine and Pharmacy], V33, P5186
   Zargar BA, 2011, FOOD CHEM, V128, P585, DOI 10.1016/j.foodchem.2011.03.083
   Zeng YQ, 2016, ONCOTARGET, V7, P17468, DOI 10.18632/oncotarget.8160
   Zhang D., 2017, WORLD LATEST MED INF, V17, P252
   Zhang Q, 2018, PEERJ, V6, DOI 10.7717/peerj.4446
   Zhang WY, 2017, J FUNCT FOODS, V39, P139, DOI 10.1016/j.jff.2017.10.020
   Zhao C, 2018, MOL NUTR FOOD RES, V62, DOI 10.1002/mnfr.201700730
   Zhao LP, 2018, SCIENCE, V359, P1151, DOI 10.1126/science.aao5774
   Zheng JP, 2018, CARBOHYD POLYM, V190, P77, DOI 10.1016/j.carbpol.2018.02.058
   郭松, 2015, [生理科学进展, Progress in Physiological Sciences], V46, P115
NR 61
TC 43
Z9 47
U1 4
U2 41
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-302X
J9 FRONT MICROBIOL
JI Front. Microbiol.
PD JUN 25
PY 2019
VL 10
AR 1423
DI 10.3389/fmicb.2019.01423
PG 11
WC Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology
GA IF4RT
UT WOS:000473069800003
PM 31293553
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Khat-udomkiri, N
   Toejing, P
   Sirilun, S
   Chaiyasut, C
   Lailerd, N
AF Khat-udomkiri, Nuntawat
   Toejing, Parichart
   Sirilun, Sasithorn
   Chaiyasut, Chaiyavat
   Lailerd, Narissara
TI Antihyperglycemic effect of rice husk derived xylooligosaccharides in
   high-fat diet and low-dose streptozotocin-induced type 2 diabetic rat
   model
SO FOOD SCIENCE & NUTRITION
LA English
DT Article
DE antihyperglycemia; diabetes mellitus; gut microbiota; prebiotic; rice
   husk; xylooligosaccharides
ID ACTIVATED PROTEIN-KINASE; INTESTINAL MICROBIOTA; GUT MICROBIOTA; GLUT4
   TRANSLOCATION; GLUCOSE-TRANSPORT; BLOOD-GLUCOSE; IN-VITRO; MECHANISM;
   ACIDS; BIFIDOBACTERIUM
AB Rice husk (RH) is an agricultural waste obtained from rice milling process. Our previous study demonstrated the optimized process of extracting xylooligosaccharides (XOS), a prebiotic that can support the growth and activity of beneficial gut microbiota, from RH. Accumulated evidences indicate that the composition of gut microbiota is involved in the progression of insulin resistance and diabetes. This study aims to evaluate the antihyperglycemic effect and putative mechanisms of RH-XOS using a diabetic rat model induced by high-fat diet and streptozotocin injection. Diabetic rats were randomly assigned to receive vehicle (DMC), XOS (DM-XOS), metformin (DMM), and a combination of XOS and metformin (DMM-XOS). An additional group of rats were fed with normal diet plus vehicle (NDC) and normal diet plus XOS (ND-XOS). Supplementation with RH-XOS for 12 weeks successfully decreased the fasting plasma glucose, insulin, leptin, and LPS levels in DM-XOS compared with DMC. Likewise, the insulin-stimulated glucose uptake assessed by in vitro study was significantly enhanced in DM-XOS, DMM, and DMM-XOS. The diminished protein expressions of GLUT4 and pAkt(Ser473) as well as pAMPK(Thr172) were significantly modulated in DM-XOS, DMM, and DMM-XOS groups. Interestingly, RH-XOS supplementation reversed the changed gut permeability, elevated the number of beneficial bacteria, both Lactobacillus and Bifidobacterium spp., and increased SCFAs production. Taken together, the results confirm the efficacy of RH-XOS in achieving good glycemic control in diabetes by maintenance of gut microbiota and attenuation of endotoxemia. The findings reveal the benefits of RH-XOS and open an opportunity to improve its value by its development as a nutraceutical for diabetes.
C1 [Khat-udomkiri, Nuntawat; Sirilun, Sasithorn; Chaiyasut, Chaiyavat; Lailerd, Narissara] Chiang Mai Univ, Innovat Ctr Holist Hlth Nutraceut & Cosmeceut, Fac Pharm, Chiang Mai 50200, Thailand.
   [Toejing, Parichart; Lailerd, Narissara] Chiang Mai Univ, Dept Physiol, Fac Med, Chiang Mai 50200, Thailand.
C3 Chiang Mai University; Chiang Mai University
RP Lailerd, N (通讯作者)，Chiang Mai Univ, Innovat Ctr Holist Hlth Nutraceut & Cosmeceut, Fac Pharm, Chiang Mai 50200, Thailand.; Lailerd, N (通讯作者)，Chiang Mai Univ, Dept Physiol, Fac Med, Chiang Mai 50200, Thailand.
EM narissara.lailerd@cmu.ac.th
RI chaiyasut, chaiyavat/AAU-8085-2021; Sivamaruthi, Bhagavathi
   Sundaram/S-5580-2016
OI chaiyasut, chaiyavat/0000-0002-1633-2419; Sivamaruthi, Bhagavathi
   Sundaram/0000-0002-5499-8350; SIRILUN, SASITHORN/0000-0002-1508-2358;
   Lailerd, Narissara/0000-0002-5439-5365; Khat-udomkiri,
   Nuntawat/0000-0003-2635-3229
FU National Research Council of Thailand (NRCT) [270390]; Thailand Science
   Research and Innovation (TSRI) [PHD/0122/2556]
FX National Research Council of Thailand (NRCT), Grant/Award Number:
   270390; Royal Golden Jubilee Ph.D. Scholarship under Thailand Science
   Research and Innovation (TSRI), Grant/Award Number: PHD/0122/2556
CR Aachary AA, 2011, COMPR REV FOOD SCI F, V10, P2, DOI 10.1111/j.1541-4337.2010.00135.x
   Amer Diabet Assoc, 2014, DIABETES CARE, V37, pS81, DOI [10.2337/dc13-S067, 10.2337/dc14-S081, 10.2337/dc13-S011, 10.2337/dc10-S062, 10.2337/dc10-S011, 10.2337/dc11-S062, 10.2337/dc12-s064, 10.2337/dc11-S011]
   Apichai S., 2012, Chiang Mai University Journal of Natural Sciences, V11, P371
   Arbex MA, 2012, J BRAS PNEUMOL, V38, P643, DOI 10.1590/S1806-37132012000500015
   Bartosch S, 2004, APPL ENVIRON MICROB, V70, P3575, DOI 10.1128/AEM.70.6.3575-3581.2004
   Brown K, 2012, NUTRIENTS, V4, P1095, DOI [10.3390/nu4081095, 10.3390/nu4111552]
   Canfora EE, 2015, NAT REV ENDOCRINOL, V11, P577, DOI 10.1038/nrendo.2015.128
   Cani PD, 2009, GUT, V58, P1091, DOI 10.1136/gut.2008.165886
   Cao SC, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0051709
   Carding Simon, 2015, Microbial Ecology in Health and Disease, V26, P26191, DOI 10.3402/mehd.v26.26191
   Castro A.M., 2017, REV MEDICA HOSP GEN, V80, P101, DOI [10.1016/j.hgmx.2016.06.011, DOI 10.1016/J.HGMX.2016.06.011]
   Christensen Ellen Gerd, 2014, BMC Res Notes, V7, P660, DOI 10.1186/1756-0500-7-660
   Claesson MJ, 2012, NATURE, V488, P178, DOI 10.1038/nature11319
   Condette CJ, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0102217
   Cryan JF, 2011, NEUROGASTROENT MOTIL, V23, P187, DOI 10.1111/j.1365-2982.2010.01664.x
   den Besten G, 2013, J LIPID RES, V54, P2325, DOI 10.1194/jlr.R036012
   Eckburg PB, 2005, SCIENCE, V308, P1635, DOI 10.1126/science.1110591
   Finegold SM, 2014, FOOD FUNCT, V5, P436, DOI 10.1039/c3fo60348b
   FRAYN KN, 1980, J LIPID RES, V21, P139
   Gobinath D, 2010, BRIT J NUTR, V104, P40, DOI 10.1017/S0007114510000243
   Han JL, 2014, WORLD J GASTROENTERO, V20, P17737, DOI 10.3748/wjg.v20.i47.17737
   Hawrelak Jason A, 2004, Altern Med Rev, V9, P180
   Hsu CK, 2004, J NUTR, V134, P1523, DOI 10.1093/jn/134.6.1523
   Huang SH, 2007, CELL METAB, V5, P237, DOI 10.1016/j.cmet.2007.03.006
   Ignacio A, 2016, CLIN MICROBIOL INFEC, V22, DOI 10.1016/j.cmi.2015.10.031
   IMAIZUMI K, 1991, AGR BIOL CHEM TOKYO, V55, P199, DOI 10.1080/00021369.1991.10870553
   Jayashree B, 2014, MOL CELL BIOCHEM, V388, P203, DOI 10.1007/s11010-013-1911-4
   JUNOD A, 1967, P SOC EXP BIOL MED, V126, P201
   Kallel F, 2015, APPL BIOCHEM BIOTECH, V175, P950, DOI 10.1007/s12010-014-1308-1
   Keapai W, 2016, KOREAN J PHYSIOL PHA, V20, P581, DOI 10.4196/kjpp.2016.20.6.581
   Keenan MJ, 2013, OBESITY, V21, P981, DOI 10.1002/oby.20109
   Khat-Udomkiri N, 2018, AMB EXPRESS, V8, DOI 10.1186/s13568-018-0645-9
   Kim SH, 2014, J APPL MICROBIOL, V117, P834, DOI 10.1111/jam.12573
   Kumar G. P., 2012, INT RES J PHARM, V3, P71, DOI DOI 10.1016/J.AMJMED.2012.11.010
   Lailerd N, 2004, METABOLISM, V53, P101, DOI 10.1016/j.metabol.2003.07.014
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Lee JO, 2012, J BIOL CHEM, V287, P44121, DOI 10.1074/jbc.M112.361386
   Li XP, 2017, J AGR FOOD CHEM, V65, P3801, DOI 10.1021/acs.jafc.7b00233
   Li ZP, 2015, INT J FOOD SCI NUTR, V66, P919, DOI 10.3109/09637486.2015.1064869
   Liang HY, 2013, PLOS ONE, V8, DOI [10.1371/journal.pone.0063983, 10.1371/journal.pone.0074121]
   Lin SH, 2016, GASTROENT RES PRACT, V2016, DOI 10.1155/2016/5789232
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   MATTHEWS JNS, 1990, BRIT MED J, V300, P230, DOI 10.1136/bmj.300.6719.230
   Nohr MK, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0146840
   Pattananandecha T, 2016, PHARM BIOL, V54, P1596, DOI 10.3109/13880209.2015.1110597
   Qiang XL, 1998, METABOLISM, V47, P977, DOI 10.1016/S0026-0495(98)90354-7
   Rinttila T, 2004, J APPL MICROBIOL, V97, P1166, DOI 10.1111/j.1365-2672.2004.02409.x
   Rooj AK, 2010, BMC MICROBIOL, V10, DOI 10.1186/1471-2180-10-16
   Sabu MC, 2002, J ETHNOPHARMACOL, V80, P203, DOI 10.1016/S0378-8741(02)00026-0
   Sheu WHH, 2008, J NUTR SCI VITAMINOL, V54, P396, DOI 10.3177/jnsv.54.396
   Srinivasan K, 2005, PHARMACOL RES, V52, P313, DOI 10.1016/j.phrs.2005.05.004
   Sunil C, 2012, FOOD CHEM TOXICOL, V50, P4356, DOI 10.1016/j.fct.2012.08.046
   Szkudelski T, 2001, PHYSIOL RES, V50, P537
   Takikawa M, 2010, J NUTR, V140, P527, DOI 10.3945/jn.109.118216
   Taniguchi CM, 2006, NAT REV MOL CELL BIO, V7, P85, DOI 10.1038/nrm1837
   Thiennimitr P, 2018, NUTRITION, V54, P40, DOI 10.1016/j.nut.2018.03.005
   Thursby E, 2017, BIOCHEM J, V474, P1823, DOI 10.1042/BCJ20160510
   Tipayarom Danutawat, 2007, ScienceAsia, V33, P339, DOI 10.2306/scienceasia1513-1874.2007.33.339
   Yun H, 2009, J MED FOOD, V12, P1023, DOI 10.1089/jmf.2009.0128
NR 59
TC 19
Z9 19
U1 5
U2 18
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2048-7177
J9 FOOD SCI NUTR
JI Food Sci. Nutr.
PD JAN
PY 2020
VL 8
IS 1
BP 428
EP 444
DI 10.1002/fsn3.1327
EA DEC 2019
PG 17
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA KF8WW
UT WOS:000501365400001
PM 31993169
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Chen, H
   Yao, Y
   Wang, WB
   Wang, DS
AF Chen, Han
   Yao, Ye
   Wang, Wenbo
   Wang, Dongsheng
TI Ge-Gen-Jiao-Tai-Wan Affects Type 2 Diabetic Rats by Regulating Gut
   Microbiota and Primary Bile Acids
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID LACTOBACILLUS; RECEPTOR; POPULATION; MODULATION; MECHANISMS; SIGNATURES;
   METFORMIN; MEDICINE; OBESITY; GLP-1
AB The Ge-Gen-Jiao-Tai-Wan (GGJTW) formula has been used to treat type 2 diabetes mellitus (T2DM) in China for a long time. Our previous study has proved that GGJTW could alleviate the type 2 diabetic symptoms, but the underlying mechanisms are still unclear. This study aimed to investigate the changes in gut microbiota and primary bile acids (PBAs) to determine the potential mechanisms of GGJTW in treating T2DM.The fecal transplant method and pseudogerm-free rats were used in our study.The16S rRNA gene sequencing method was used to analyze the changes in the intestinal flora, and PBAs in the colon contents were detected. Finally, the expression of farnesoid X receptor (FXR), G protein-coupled membrane receptor 5 (TGR5), and glucagon-like peptide-1 (GLP-1) was assessed. Following GGJTW treatment, we observed a decrease in blood glucose levels and improvements in glucose tolerance and serum lipid levels. Furthermore, we found that GGJTW could regulate the composition of the gut microbiota and upregulate the diabetic beneficial phylum Firmicutes and bile-acid-related genus Lactobacillus. PBAs in the colon contents were increased in the GGJTW-treated group, accompanied by upregulated expression of the bile acid receptors FXR and TGR5 and increased concentrations of GLP-1. These results indicated that GGJTW could alleviate symptoms of type 2 diabetic rats by regulating the gut microbiota, promoting the production of PBAs, and upregulating the PBA-FXR/TGR5-GLP-1 pathway.
C1 [Chen, Han; Yao, Ye; Wang, Wenbo; Wang, Dongsheng] Cent South Univ, Inst Integrated Tradit Chinese & Western Med, Xiangya Hosp, Changsha 410008, Peoples R China.
   [Chen, Han; Yao, Ye; Wang, Wenbo; Wang, Dongsheng] Cent South Univ, Hunan Key Lab Tradit Chinese Med Gan State Adm, Changsha 410008, Peoples R China.
C3 Central South University; Central South University
RP Wang, DS (通讯作者)，Cent South Univ, Inst Integrated Tradit Chinese & Western Med, Xiangya Hosp, Changsha 410008, Peoples R China.; Wang, DS (通讯作者)，Cent South Univ, Hunan Key Lab Tradit Chinese Med Gan State Adm, Changsha 410008, Peoples R China.
EM xychenhan@aliyun.com; xyyaoye@csu.edu.cn; wangwenbo@csu.edu.cn;
   wdsh666@126.com
FU Foundation of Hunan Key Laboratory of Traditional Chinese Medicine for
   Gan of State Administration and Hunan Province Science and Technology
   Project [2016SK2008]
FX This research was supported by the Foundation of Hunan Key Laboratory of
   Traditional Chinese Medicine for Gan of State Administration and Hunan
   Province Science and Technology Project (No. 2016SK2008).
CR Gonzalez-Regueiro JA, 2017, ANN HEPATOL, V16, pS15, DOI [10.5604/01.3001.0010.5672, 10.5604/01.3001.0010.5494]
   Beli E, 2018, DIABETES, V67, P1867, DOI 10.2337/db18-0158
   Chen C, 2018, FOOD FUNCT, V9, P3732, DOI [10.1039/C7FO01346A, 10.1039/c7fo01346a]
   Demirci M, 2020, J DIABETES COMPLICAT, V34, DOI 10.1016/j.jdiacomp.2019.107449
   Di Cerbo A, 2016, J CLIN PATHOL, V69, P187, DOI 10.1136/jclinpath-2015-202976
   Ding L, 2015, ACTA PHARM SIN B, V5, P135, DOI 10.1016/j.apsb.2015.01.004
   Fang J, 2017, EVID-BASED COMPL ALT, V2017, DOI 10.1155/2017/2945803
   Fang PH, 2020, J ETHNOPHARMACOL, V250, DOI 10.1016/j.jep.2019.112483
   Fassatoui M, 2019, BIOSCIENCE REP, V39, DOI 10.1042/BSR20182348
   Fiorucci S, 2015, TRENDS MOL MED, V21, P702, DOI 10.1016/j.molmed.2015.09.001
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Friedman JM, 2004, NAT MED, V10, P563, DOI 10.1038/nm0604-563
   Gao RY, 2018, OBESITY, V26, P351, DOI 10.1002/oby.22088
   Gu YY, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-01682-2
   Heeney DD, 2018, CURR OPIN BIOTECH, V49, P140, DOI 10.1016/j.copbio.2017.08.004
   Holter MM, 2020, NUTRIENTS, V12, DOI 10.3390/nu12092598
   Huang M, 2015, CARBOHYD POLYM, V117, P91, DOI 10.1016/j.carbpol.2014.09.008
   Johnson EL, 2017, J MOL MED, V95, P1, DOI 10.1007/s00109-016-1492-2
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kim Hyeonhui, 2018, Lab Anim Res, V34, P140, DOI 10.5625/lar.2018.34.4.140
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Li RM, 2016, J ETHNOPHARMACOL, V185, P60, DOI 10.1016/j.jep.2016.03.029
   Li WC, 2020, J ETHNOPHARMACOL, V247, DOI 10.1016/j.jep.2019.112275
   Ma K, 2006, J CLIN INVEST, V116, P1102, DOI 10.1172/JCI25604
   Martin RM, 2018, FRONT CELL INFECT MI, V8, DOI 10.3389/fcimb.2018.00004
   Meier JJ, 2012, NAT REV ENDOCRINOL, V8, P728, DOI 10.1038/nrendo.2012.140
   Murota K, 2018, BIOSCI BIOTECH BIOCH, V82, P600, DOI 10.1080/09168451.2018.1444467
   Pascale A, 2019, CURR OPIN PHARMACOL, V49, P1, DOI 10.1016/j.coph.2019.03.011
   Pourramezan Z, 2018, FOLIA MICROBIOL, V63, P31, DOI 10.1007/s12223-017-0531-x
   Rossi M, 2016, ENV MICROBIOL REP, V8, P399, DOI 10.1111/1758-2229.12405
   Slattery C, 2019, NUTRIENTS, V11, DOI 10.3390/nu11061252
   Thomas C, 2009, CELL METAB, V10, P167, DOI 10.1016/j.cmet.2009.08.001
   Tian LL, 2016, J DIABETES, V8, P753, DOI 10.1111/1753-0407.12439
   Wahlstrom A, 2016, CELL METAB, V24, P41, DOI 10.1016/j.cmet.2016.05.005
   Wang H, 2018, EXPERT OPIN THER PAT, V28, P765, DOI 10.1080/13543776.2018.1527906
   Wang K, 2019, CELL REP, V26, P222, DOI 10.1016/j.celrep.2018.12.028
   Wang WB, 2018, J ETHNOPHARMACOL, V219, P299, DOI 10.1016/j.jep.2018.03.026
   Wei XY, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-22094-2
   Wexler HM, 2007, CLIN MICROBIOL REV, V20, P593, DOI 10.1128/CMR.00008-07
   Wu TR, 2019, GUT, V68, P248, DOI 10.1136/gutjnl-2017-315458
   Xu J, 2015, ISME J, V9, P552, DOI 10.1038/ismej.2014.177
   Yang JM, 2019, WORLD J GASTROENTERO, V25, P5105, DOI 10.3748/wjg.v25.i34.5105
   Yao Y, 2020, BIOMED PHARMACOTHER, V131, DOI 10.1016/j.biopha.2020.110669
   Yao Y, 2020, PHYTOMEDICINE, V77, DOI 10.1016/j.phymed.2020.153268
   Yi M, 2019, DRUG METAB PHARMACOK, V34, P340, DOI 10.1016/j.dmpk.2019.07.004
   Yin Jun, 2008, Endocrine Metabolic & Immune Disorders-Drug Targets, V8, P99, DOI 10.2174/187153008784534330
   Yue SJ, 2019, AM J PHYSIOL-ENDOC M, V316, pE73, DOI 10.1152/ajpendo.00256.2018
   Zhang T, 2019, MICROB BIOTECHNOL, V12, P1109, DOI 10.1111/1751-7915.13410
   Zhang ZY, 2017, EVID-BASED COMPL ALT, V2017, DOI 10.1155/2017/3275096
   Zhao JD, 2019, EVID-BASED COMPL ALT, V2019, DOI 10.1155/2019/6976394
   Zhao LP, 2018, SCIENCE, V359, P1151, DOI 10.1126/science.aao5774
   Zhao YH, 2019, J ETHNOPHARMACOL, V241, DOI 10.1016/j.jep.2019.111908
   Zhernakova A, 2016, SCIENCE, V352, P565, DOI 10.1126/science.aad3369
NR 53
TC 7
Z9 7
U1 4
U2 15
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PD APR 16
PY 2021
VL 2021
DI 10.1155/2021/5585952
PG 13
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA SV9FE
UT WOS:000664122300001
PM 33953783
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Liu, YY
   Wang, CR
   Li, JS
   Li, TT
   Zhang, Y
   Liang, YX
   Mei, YX
AF Liu, Yangyang
   Wang, Chaorui
   Li, Jinshan
   Li, Tiantian
   Zhang, Yong
   Liang, Yunxiang
   Mei, Yuxia
TI Phellinus linteus polysaccharide extract improves insulin resistance by
   regulating gut microbiota composition
SO FASEB JOURNAL
LA English
DT Article
DE gut microbiota; insulin signaling; inflammation; Phellinus linteus
   polysaccharide; short-chain fatty acids
ID CHAIN FATTY-ACIDS; DIETARY FIBER; AGARICUS-BISPORUS; OBESITY;
   STREPTOZOTOCIN; METABOLISM; FERMENTATION; DYSFUNCTION; INDIVIDUALS;
   METAGENOME
AB The hypoglycemic effect of Phellinus linteus polysaccharide extract (PLPE) has been documented in several previous studies, but the functional interactions among PLPE, gut microbiota, and the hypoglycemic effect remain unclear. We examined the regulatory effect of PLPE on gut microbiota, and the molecular mechanism underlying improvement of insulin resistance, using a type 2 diabetic rat model. Here, 24 male Sprague-Dawley rats were randomly divided into four groups that were subjected to intervention of saline (normal and model control group), metformin (120 mg/kg.bw), and PLPE (600 mg/kg.bw) by oral administration. After 8 weeks of treatment, PLPE increased levels of short-chain fatty acids (SCFAs) by enhancing abundance of SCFA-producing bacteria. SCFAs maintained intestinal barrier function and reduced lipopolysaccharides content in blood, thereby helping to reduce systemic inflammation and reverse insulin resistance. Our findings suggest that PLPE (in which polysaccharides are the major component) has potential application as a prebiotic for regulating gut microbiota composition in diabetic patients.
C1 [Liu, Yangyang; Wang, Chaorui; Li, Jinshan; Li, Tiantian; Zhang, Yong; Liang, Yunxiang; Mei, Yuxia] Huazhong Agr Univ, Coll Life Sci & Technol, State Key Lab Agr Microbiol, Wuhan 430070, Hubei, Peoples R China.
   [Mei, Yuxia] Univ Calif Davis, Dept Chem, Davis, CA 95616 USA.
C3 Huazhong Agricultural University; University of California System;
   University of California Davis
RP Mei, YX (通讯作者)，Huazhong Agr Univ, Coll Life Sci & Technol, State Key Lab Agr Microbiol, Wuhan 430070, Hubei, Peoples R China.
EM mei@mail.hzau.edu.cn
RI Li, Jinshan/AAQ-9461-2020
OI Li, Jinshan/0000-0003-3109-5092
FU State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural
   University; Fundamental Research Funds for the Central Universities of
   China [2662019PY066, 2662016PY132]; China Scholarship Council
   [201706765055]
FX This study was supported by funds from the State Key Laboratory of
   Agricultural Microbiology, Huazhong Agricultural University, Fundamental
   Research Funds for the Central Universities of China (grant No.
   2662019PY066, No. 2662016PY132), and a special grant from China
   Scholarship Council (No. 201706765055). The authors are grateful to Dr.
   S. Anderson for English editing of the manuscript.
CR Canfora EE, 2015, NAT REV ENDOCRINOL, V11, P577, DOI 10.1038/nrendo.2015.128
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   Chen H, 2016, FITOTERAPIA, V113, P6, DOI 10.1016/j.fitote.2016.06.009
   Cho NH, 2018, DIABETES RES CLIN PR, V138, P271, DOI 10.1016/j.diabres.2018.02.023
   de Assis AM, 2009, EXP BIOL MED, V234, P1296, DOI 10.3181/0904-RM-126
   De Vadder F, 2014, CELL, V156, P84, DOI 10.1016/j.cell.2013.12.016
   Desai MS, 2016, CELL, V167, P1339, DOI 10.1016/j.cell.2016.10.043
   Ding QA, 2017, FOOD HYDROCOLLOID, V63, P646, DOI 10.1016/j.foodhyd.2016.10.018
   Duan YH, 2019, FASEB J, V33, P10019, DOI 10.1096/fj.201900665RR
   Duncan SH, 2016, ENVIRON MICROBIOL, V18, P2214, DOI 10.1111/1462-2920.13158
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Feng H, 2018, CARBOHYD POLYM, V200, P144, DOI 10.1016/j.carbpol.2018.07.086
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Hanley AJG, 2002, DIABETES CARE, V25, P1177, DOI 10.2337/diacare.25.7.1177
   Hehemann JH, 2019, ISME J, V13, P1883, DOI 10.1038/s41396-019-0406-z
   Hernandez JB, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms8216
   Hu T, 2018, CARBOHYD POLYM, V200, P487, DOI 10.1016/j.carbpol.2018.08.021
   Hwang HJ, 2008, KOREAN J CHEM ENG, V25, P308, DOI 10.1007/s11814-008-0054-x
   Jakobsdottir G, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0080476
   Jayachandran M, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18091934
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kieler IN, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-41195-0
   Koh A, 2016, CELL, V165, P1332, DOI 10.1016/j.cell.2016.05.041
   Kovatcheva-Datchary P, 2015, CELL METAB, V22, P971, DOI 10.1016/j.cmet.2015.10.001
   Liu YY, 2019, NUTRIENTS, V11, DOI 10.3390/nu11020296
   Makki K, 2018, CELL HOST MICROBE, V23, P705, DOI 10.1016/j.chom.2018.05.012
   Martel J, 2017, NAT REV ENDOCRINOL, V13, P149, DOI 10.1038/nrendo.2016.142
   Martens EC, 2018, NAT REV MICROBIOL, V16, P457, DOI 10.1038/s41579-018-0036-x
   Mei YX, 2015, CARBOHYD POLYM, V124, P90, DOI 10.1016/j.carbpol.2015.02.009
   Musso G, 2011, ANNU REV MED, V62, P361, DOI 10.1146/annurev-med-012510-175505
   Ng SF, 2010, NATURE, V467, P963, DOI 10.1038/nature09491
   Palacio J C, 1990, Nutr Clin Pract, V5, P99, DOI 10.1177/011542659000500399
   Puddu Alessandra, 2014, Mediators Inflamm, V2014, P162021, DOI 10.1155/2014/162021
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Ravachol J, 2016, SCI REP-UK, V6, DOI 10.1038/srep22770
   Scott TA, 2017, CELL, V169, P442, DOI 10.1016/j.cell.2017.03.040
   Singh A, 2019, FASEB J, V33, P6748, DOI 10.1096/fj.201801627RRR
   Solano-Aguilar GI, 2018, NUTRIENTS, V10, DOI 10.3390/nu10111721
   Sonnenburg ED, 2014, CELL METAB, V20, P779, DOI 10.1016/j.cmet.2014.07.003
   Tian Y, 2018, J FUNCT FOODS, V45, P223, DOI 10.1016/j.jff.2018.04.008
   Uyanoglu M, 2014, INT J FOOD SCI NUTR, V65, P482, DOI 10.3109/09637486.2013.869796
   Vanegas SM, 2017, AM J CLIN NUTR, V105, P635, DOI 10.3945/ajcn.116.146928
   Vrieze A, 2012, GASTROENTEROLOGY, V143, P913, DOI 10.1053/j.gastro.2012.06.031
   Wan Y, 2019, GUT, V68, P1417, DOI 10.1136/gutjnl-2018-317609
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Wu TR, 2019, GUT, V68, P248, DOI 10.1136/gutjnl-2017-315458
   Yang Q, 2018, NAT REV MOL CELL BIO, V19, P654, DOI 10.1038/s41580-018-0044-8
   Yang WY, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0205784
   You YM, 2015, FOOD FUNCT, V6, P3144, DOI 10.1039/c5fo00432b
   Zhang BW, 2018, J FUNCT FOODS, V46, P256, DOI 10.1016/j.jff.2018.04.070
   Zhao C, 2014, J FOOD SCI, V79, pH1002, DOI 10.1111/1750-3841.12464
   Zhao GH, 2006, BIOMED CHROMATOGR, V20, P674, DOI 10.1002/bmc.580
   Zhao LP, 2018, SCIENCE, V359, P1151, DOI 10.1126/science.aao5774
   Zhou D, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-01751-y
NR 55
TC 47
Z9 53
U1 19
U2 89
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD JAN
PY 2020
VL 34
IS 1
BP 1065
EP 1078
DI 10.1096/fj.201901943RR
PG 14
WC Biochemistry & Molecular Biology; Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA KC6TY
UT WOS:000507308900072
PM 31914668
DA 2023-06-08
ER

PT J
AU Proffitt, C
   Bidkhori, G
   Moyes, D
   Shoaie, S
AF Proffitt, Ceri
   Bidkhori, Gholamreza
   Moyes, David
   Shoaie, Saeed
TI Disease, Drugs and Dysbiosis: Understanding Microbial Signatures in
   Metabolic Disease and Medical Interventions
SO MICROORGANISMS
LA English
DT Review
DE metabolic diseases; metagenomics; systems biology; dysbiosis; gut
   microbiota
ID ARYL-HYDROCARBON RECEPTOR; HUMAN GUT MICROBIOTA; BARIATRIC SURGERY;
   GASTRIC BYPASS; WEIGHT-LOSS; BILE-ACIDS; AMINO-ACIDS; METFORMIN;
   OBESITY; RISK
AB Since the discovery of the potential role for the gut microbiota in health and disease, many studies have gone on to report its impact in various pathologies. These studies have fuelled interest in the microbiome as a potential new target for treating disease Here, we reviewed the key metabolic diseases, obesity, type 2 diabetes and atherosclerosis and the role of the microbiome in their pathogenesis. In particular, we will discuss disease associated microbial dysbiosis; the shift in the microbiome caused by medical interventions and the altered metabolite levels between diseases and interventions. The microbial dysbiosis seen was compared between diseases including Crohn's disease and ulcerative colitis, non-alcoholic fatty liver disease, liver cirrhosis and neurodegenerative diseases, Alzheimer's and Parkinson's. This review highlights the commonalities and differences in dysbiosis of the gut between diseases, along with metabolite levels in metabolic disease vs. the levels reported after an intervention. We identify the need for further analysis using systems biology approaches and discuss the potential need for treatments to consider their impact on the microbiome.
C1 [Proffitt, Ceri; Bidkhori, Gholamreza; Moyes, David; Shoaie, Saeed] Kings Coll London, Fac Dent Oral & Craniofacial Sci, Ctr Host Microbiome Interact, London SE1 9RT, England.
   [Shoaie, Saeed] KTH Royal Inst Technol, Dept Prot Sci, Sci Life Lab, S-11417 Stockholm, Sweden.
C3 RLUK- Research Libraries UK; University of London; King's College
   London; Royal Institute of Technology
RP Proffitt, C; Shoaie, S (通讯作者)，Kings Coll London, Fac Dent Oral & Craniofacial Sci, Ctr Host Microbiome Interact, London SE1 9RT, England.; Shoaie, S (通讯作者)，KTH Royal Inst Technol, Dept Prot Sci, Sci Life Lab, S-11417 Stockholm, Sweden.
EM ceriproffitt@kcl.ac.uk; gholamreza.bidkhori@kcl.ac.uk;
   david.moyes@kcl.ac.uk; saeed.shoaie@kcl.ac.uk
RI Stefanadis, Christodoulos/ABH-2232-2020
OI Stefanadis, Christodoulos/0000-0001-5974-6454; Moyes,
   David/0000-0002-1657-918X; Proffitt, Ceri/0000-0003-3820-735X; Shoaie,
   Saeed/0000-0001-5834-4533
FU Engineering and Physical Sciences Research Council (EPSRC)
   [EP/S001301/1]; BBSRC award [BB/M009513/1]; King's College London;
   Science for Life Laboratory; BBSRC [BB/S016899/1] Funding Source: UKRI;
   EPSRC [EP/S001301/1] Funding Source: UKRI
FX This study was supported by Engineering and Physical Sciences Research
   Council (EPSRC), (EP/S001301/1) award to SS, and a BBSRC award
   (BB/M009513/1) to DLM, as well as by funding from King's College London
   and Science for Life Laboratory.
CR Al Assal K, 2020, NUTRIENTS, V12, DOI 10.3390/nu12020278
   Alfa MJ, 2018, CLIN NUTR, V37, P797, DOI 10.1016/j.clnu.2017.03.025
   Alfaras I, 2017, NPJ AGING MECH DIS, V3, DOI 10.1038/s41514-017-0018-7
   Aron-Wisnewsky J, 2019, GUT, V68, P70, DOI 10.1136/gutjnl-2018-316103
   Arumugam M, 2011, NATURE, V473, P174, DOI 10.1038/nature09944
   Ashrafian H, 2013, METAB BRAIN DIS, V28, P341, DOI 10.1007/s11011-013-9412-4
   Balakumar P, 2016, PHARMACOL RES, V113, P600, DOI 10.1016/j.phrs.2016.09.040
   Baldini F, 2019, BIOINFORMATICS, V35, P2332, DOI 10.1093/bioinformatics/bty941
   Bhole V, 2010, AM J MED, V123, P957, DOI 10.1016/j.amjmed.2010.03.027
   Brunk E, 2018, NAT BIOTECHNOL, V36, P272, DOI 10.1038/nbt.4072
   Bryrup T, 2019, DIABETOLOGIA, V62, P1024, DOI 10.1007/s00125-019-4848-7
   Byrd AL, 2018, NAT REV MICROBIOL, V16, P143, DOI 10.1038/nrmicro.2017.157
   Cason CA, 2018, J VASC SURG, V68, P1552, DOI 10.1016/j.jvs.2017.09.029
   Chakraborty A, 2011, DIABETES RES CLIN PR, V93, P56, DOI 10.1016/j.diabres.2010.11.030
   Charach G, 2012, INT J VASC MED, V2012, DOI 10.1155/2012/949672
   Chen YH, 2016, SCI REP-UK, V6, DOI 10.1038/srep24253
   Cho I, 2012, NATURE, V488, P621, DOI 10.1038/nature11400
   Clooney AG, 2016, ALIMENT PHARM THER, V43, P974, DOI 10.1111/apt.13568
   Collins FS, 2004, NATURE, V431, P931, DOI 10.1038/nature03001
   Cotillard A, 2013, NATURE, V500, P585, DOI 10.1038/nature12480
   Dimidi E, 2019, NUTRIENTS, V11, DOI 10.3390/nu11081806
   Dominguez-Bello MG, 2010, P NATL ACAD SCI USA, V107, P11971, DOI 10.1073/pnas.1002601107
   Dong TS, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-59535-w
   Duranti S, 2016, FEMS MICROBIOL ECOL, V92, DOI 10.1093/femsec/fiw191
   Einarson TR, 2018, CARDIOVASC DIABETOL, V17, DOI 10.1186/s12933-018-0728-6
   Ejtahed HS, 2019, EUR J ENDOCRINOL, V180, P165, DOI [10.1530/EJE-18-0826, 10.1530/eje-18-0826]
   Falony G, 2016, SCIENCE, V352, P560, DOI 10.1126/science.aad3503
   Fernandez-Berges D, 2014, REV ESP CARDIOL, V67, P624, DOI [10.1016/j.rec.2013.10.019, 10.1016/j.recesp.2013.10.021]
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Furet JP, 2010, DIABETES, V59, P3049, DOI 10.2337/db10-0253
   Gaulke CA, 2018, NAT MED, V24, P1495, DOI 10.1038/s41591-018-0210-8
   Geirnaert A, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-11734-8
   Gentile CL, 2018, SCIENCE, V362, P776, DOI 10.1126/science.aau5812
   Ghaffari P, 2015, SCI REP-UK, V5, DOI 10.1038/srep08183
   Glass Lisa M, 2019, Fed Pract, V36, P64
   Graessler J, 2013, PHARMACOGENOMICS J, V13, P514, DOI 10.1038/tpj.2012.43
   Green S, 2018, SYNTHESE, V195, P1751, DOI 10.1007/s11229-016-1307-6
   Gregorio F, 1996, DIABETES METAB, V22, P43
   Haran JP, 2019, MBIO, V10, DOI 10.1128/mBio.00632-19
   Heinken A, 2013, GUT MICROBES, V4, P28, DOI 10.4161/gmic.22370
   Hill CB, 2015, FRONT BIOENG BIOTECH, V3, DOI 10.3389/fbioe.2015.00167
   Hill-Burns EM, 2017, MOVEMENT DISORD, V32, P739, DOI 10.1002/mds.26942
   Hofmann AF, 1999, NEWS PHYSIOL SCI, V14, P24, DOI 10.1152/physiologyonline.1999.14.1.24
   Imhann F, 2016, GUT, V65, P740, DOI 10.1136/gutjnl-2015-310376
   Inoue R, 2017, J CLIN BIOCHEM NUTR, V61, P217, DOI 10.3164/jcbn.17-44
   Insull W, 2009, AM J MED, V122, pS3, DOI 10.1016/j.amjmed.2008.10.013
   Javdan B, 2020, CELL, V181, P1661, DOI 10.1016/j.cell.2020.05.001
   Jennis M, 2018, NEUROGASTROENT MOTIL, V30, DOI 10.1111/nmo.13178
   Jie ZY, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-00900-1
   Jones CMA, 2020, INFLAMM BOWEL DIS, V26, P1026, DOI 10.1093/ibd/izaa001
   Kadow S, 2011, J IMMUNOL, V187, P3104, DOI 10.4049/jimmunol.1100912
   Kampoli AM, 2009, TRENDS MOL MED, V15, P323, DOI 10.1016/j.molmed.2009.06.001
   Karlsson F, 2013, DIABETES, V62, P3341, DOI 10.2337/db13-0844
   Karlsson FH, 2012, NAT COMMUN, V3, DOI 10.1038/ncomms2266
   Karlsson FH, 2011, TRENDS BIOTECHNOL, V29, P251, DOI 10.1016/j.tibtech.2011.01.009
   Khosravi A, 2013, CURR OPIN MICROBIOL, V16, P221, DOI 10.1016/j.mib.2013.03.009
   Kim KN, 2019, NUTRIENTS, V11, DOI 10.3390/nu11102512
   Klepser TB, 1997, AM J HEALTH-SYST PH, V54, P893, DOI 10.1093/ajhp/54.8.893
   Knoll RL, 2017, AM J PHYSIOL-GASTR L, V312, pG327, DOI 10.1152/ajpgi.00293.2016
   Lee CJ, 2019, OBES SURG, V29, P3239, DOI 10.1007/s11695-019-03976-4
   Lee J, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-13991-z
   Lee SE, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0194490
   Lefebvre P, 2009, PHYSIOL REV, V89, P147, DOI 10.1152/physrev.00010.2008
   Lewis JD, 2015, CELL HOST MICROBE, V18, P489, DOI 10.1016/j.chom.2015.09.008
   Li LY, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-12087-8
   Liu J, 2020, NAT MED, V26, P110, DOI 10.1038/s41591-019-0722-x
   Liu RX, 2017, NAT MED, V23, P859, DOI 10.1038/nm.4358
   Liu ZH, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.01687
   Long AN, 2011, J CLIN HYPERTENS, V13, P244, DOI 10.1111/j.1751-7176.2011.00434.x
   Louis S, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0149564
   Madiraju AK, 2014, NATURE, V510, P542, DOI 10.1038/nature13270
   Magnusdottir S, 2017, NAT BIOTECHNOL, V35, P81, DOI 10.1038/nbt.3703
   Mangge H, 2016, J NUTR BIOCHEM, V32, P123, DOI 10.1016/j.jnutbio.2016.02.007
   Mardinoglu A, 2018, NAT REV GASTRO HEPAT, V15, P365, DOI 10.1038/s41575-018-0007-8
   Maron DJ, 2000, CIRCULATION, V101, P207, DOI 10.1161/01.CIR.101.2.207
   Martinez G, 2017, GLOBAL MEDIA GIANTS, P191
   McCreight LJ, 2016, DIABETOLOGIA, V59, P426, DOI 10.1007/s00125-015-3844-9
   Miettinen TA, 2000, ATHEROSCLEROSIS, V153, P241, DOI 10.1016/S0021-9150(00)00404-4
   Monteleone I, 2011, GASTROENTEROLOGY, V141, P237, DOI 10.1053/j.gastro.2011.04.007
   Murphy R, 2017, OBES SURG, V27, P917, DOI 10.1007/s11695-016-2399-2
   Musi N, 2002, DIABETES, V51, P2074, DOI 10.2337/diabetes.51.7.2074
   Noble Douglas, 2011, BMJ, V343, pd7163, DOI 10.1136/bmj.d7163
   Nussbaum RL, 2003, NEW ENGL J MED, V348, P1356, DOI 10.1056/NEJM2003ra020003
   O'Brien EJ, 2015, CELL, V161, P971, DOI 10.1016/j.cell.2015.05.019
   Oberbach A, 2014, METABOLISM, V63, P242, DOI 10.1016/j.metabol.2013.11.012
   Okekunle AP, 2017, DIABETES RES CLIN PR, V132, P45, DOI 10.1016/j.diabres.2017.07.023
   Paisse S, 2016, TRANSFUSION, V56, P1138, DOI 10.1111/trf.13477
   Palleja A, 2016, GENOME MED, V8, DOI 10.1186/s13073-016-0312-1
   Pasini E, 2019, MINERVA MED, V110, P3, DOI 10.23736/S0026-4806.18.05589-1
   Pasolli E, 2016, PLOS COMPUT BIOL, V12, DOI 10.1371/journal.pcbi.1004977
   Peterfreund GL, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0046966
   Petrov VA, 2017, B EXP BIOL MED+, V162, P734, DOI 10.1007/s10517-017-3700-7
   Pevsner-Fischer M, 2017, CURR OPIN NEPHROL HY, V26, P1, DOI 10.1097/MNH.0000000000000293
   Pihlajamaki J, 2010, METABOLISM, V59, P866, DOI 10.1016/j.metabol.2009.10.004
   POULIOT MC, 1992, DIABETES, V41, P826, DOI 10.2337/diabetes.41.7.826
   Preiss D, 2016, DIABETIC MED, V33, P1569, DOI 10.1111/dme.13097
   Rodriguez-Castano GP, 2017, FRONT GENET, V7, DOI 10.3389/fgene.2016.00224
   Roglic G., 2016, INT J NONCOMMUN DIS, V1, P3, DOI [10.4103/2468-8827.184853, DOI 10.4103/2468-8827.184853]
   Schellenberg ES, 2013, ANN INTERN MED, V159, P543, DOI 10.7326/0003-4819-159-8-201310150-00007
   Scher JU, 2020, NAT REV RHEUMATOL, V16, P282, DOI 10.1038/s41584-020-0395-3
   Schmieder RE, 2017, J CLIN HYPERTENS, V19, P126, DOI 10.1111/jch.12936
   Shah SH, 2010, CIRC-CARDIOVASC GENE, V3, P207, DOI 10.1161/CIRCGENETICS.109.852814
   Shao L, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.03166
   Shoaie S, 2015, CELL METAB, V22, P320, DOI 10.1016/j.cmet.2015.07.001
   Shoaie S, 2013, SCI REP-UK, V3, DOI 10.1038/srep02532
   Shoelson SE, 2006, J CLIN INVEST, V116, P1793, DOI 10.1172/JCI29069
   Shreiner AB, 2015, CURR OPIN GASTROEN, V31, P69, DOI 10.1097/MOG.0000000000000139
   Simonen M, 2012, OBES SURG, V22, P1473, DOI 10.1007/s11695-012-0673-5
   Singh RK, 2017, J TRANSL MED, V15, DOI 10.1186/s12967-017-1175-y
   Smith PM, 2013, SCIENCE, V341, P569, DOI 10.1126/science.1241165
   Soletsky B, 2012, HYPERTENSION, V60, P1148, DOI 10.1161/HYPERTENSIONAHA.112.196980
   Stanislawski MA, 2019, NPJ BIOFILMS MICROBI, V5, DOI 10.1038/s41522-019-0091-8
   Subramanian I, 2020, BIOINFORM BIOL INSIG, V14, DOI 10.1177/1177932219899051
   Sugerman HJ, 2003, ANN SURG, V237, P751, DOI 10.1097/00000658-200306000-00002
   Talley NJ, 2002, LANCET, V360, P555, DOI 10.1016/S0140-6736(02)09712-X
   Tremaroli V, 2015, CELL METAB, V22, P228, DOI 10.1016/j.cmet.2015.07.009
   Trevathan-Tackett SM, 2019, NAT ECOL EVOL, V3, P1509, DOI 10.1038/s41559-019-0999-7
   Ulker I, 2019, BIOSCI MICROB FOOD H, V38, P3, DOI 10.12938/bmfh.18-018
   Varemo L, 2013, FRONT PHYSIOL, V4, DOI 10.3389/fphys.2013.00092
   Vieira-Silva S, 2020, NATURE, V581, P310, DOI 10.1038/s41586-020-2269-x
   Vila AV, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-019-14177-z
   Vila AV, 2018, SCI TRANSL MED, V10, DOI 10.1126/scitranslmed.aap8914
   Vogt NM, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-13601-y
   Wade WG, 2013, PHARMACOL RES, V69, P137, DOI 10.1016/j.phrs.2012.11.006
   Wang BH, 2016, SCI REP-UK, V6, DOI 10.1038/srep32002
   Wijayatunga NN, 2018, DIABETES-METAB RES, V34, DOI 10.1002/dmrr.3045
   Wu GD, 2011, SCIENCE, V334, P105, DOI 10.1126/science.1208344
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Young SG, 2012, NEW ENGL J MED, V366, P1154, DOI 10.1056/NEJMe1202168
   Zhao LJ, 2019, ENDOCRINE, V66, P526, DOI 10.1007/s12020-019-02103-8
   Zhao LP, 2018, SCIENCE, V359, P1151, DOI 10.1126/science.aao5774
   Zhong HZ, 2019, EBIOMEDICINE, V47, P373, DOI 10.1016/j.ebiom.2019.08.048
   Zomorrodi AR, 2012, PLOS COMPUT BIOL, V8, DOI 10.1371/journal.pcbi.1002363
NR 133
TC 7
Z9 8
U1 0
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-2607
J9 MICROORGANISMS
JI Microorganisms
PD SEP
PY 2020
VL 8
IS 9
AR 1381
DI 10.3390/microorganisms8091381
PG 17
WC Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology
GA OD7BI
UT WOS:000580004200001
PM 32916966
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Cornejo-Pareja, I
   Munoz-Garach, A
   Clemente-Postigo, M
   Tinahones, FJ
AF Cornejo-Pareja, Isabel
   Munoz-Garach, Araceli
   Clemente-Postigo, Mercedes
   Tinahones, Francisco J.
TI Importance of gut microbiota in obesity
SO EUROPEAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article; Proceedings Paper
CT 11th International Mediterranean Diet Conference on Mediterranean Diet
   as a Lifestyle and Dynamic Food Pattern
CY APR, 2016
CL Barcelona, SPAIN
ID DIET-INDUCED OBESITY; WEIGHT-LOSS; INTESTINAL MICROBIOTA;
   AKKERMANSIA-MUCINIPHILA; METABOLIC SYNDROME; ADIPOSE-TISSUE; BODY
   HABITATS; DELIVERY MODE; FAT; OVERWEIGHT
AB Recently, a number of studies have related the development of highly prevalent disorders such as type 2 diabetes and obesity to gut microbiota. Obesity itself have been associated with modifications in gut microbiota composition, and a tendency towards an overgrowth of microorganisms that obtain more efficient energy from diet. It's capacity to decompose the polysaccharides that can not be digested by the host, increase monosaccharide and short chain fatty acid (SCFA) production. However, the increase in fat mass is not only due to a more efficient harvest of energy, but also the microbiota participates in changes in endotoxemia, bowel permeability, insulin resistance, hormonal environment, expression of genes regulating lipogenesis, interaction with bile acids, as well as changes in the proportion of brown adipose tissue, and effects associated with the use of drugs such as metformin. Currently, use of prebiotics and probiotics and other innovative techniques like antibiotic therapy or gut microbiota transplant, has been proposed as suitable tools to control the development of metabolic diseases such as obesity or insulin resistance through the diet.
C1 [Cornejo-Pareja, Isabel; Munoz-Garach, Araceli; Clemente-Postigo, Mercedes; Tinahones, Francisco J.] Univ Malaga, Complejo Hosp Malaga Virgen Victoria, Inst Invest Biomed Malaga IBIMA, Unidad Gest Clin Endocrinol & Nutr, Malaga, Spain.
   [Cornejo-Pareja, Isabel; Munoz-Garach, Araceli; Clemente-Postigo, Mercedes; Tinahones, Francisco J.] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBEROBN 06 03, Malaga, Spain.
C3 Instituto de Investigacion Biomedica de Malaga y Plataforma en
   Nanomedicina (IBIMA); Universidad de Malaga; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEROBN; Instituto de Salud Carlos III
RP Tinahones, FJ (通讯作者)，Univ Malaga, Complejo Hosp Malaga Virgen Victoria, Inst Invest Biomed Malaga IBIMA, Unidad Gest Clin Endocrinol & Nutr, Malaga, Spain.; Tinahones, FJ (通讯作者)，Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBEROBN 06 03, Malaga, Spain.
EM fjtinahones@hotmail.com
RI Clemente-Postigo, Mercedes/AAA-1102-2020; Muñoz-Garach,
   Araceli/A-9791-2016; Tinahones, Francisco José/AAB-2882-2020
OI Muñoz-Garach, Araceli/0000-0002-1867-1158; Clemente-Postigo,
   Mercedes/0000-0002-4146-6662; Tinahones, Francisco J/0000-0001-6871-4403
FU Institute of Health Carlos III [PI15/01114]; Ministry of Innovation,
   Science and Enterprise of the Junta de Andalucia [CTS-8181]; Spanish
   Ministry of Economy and Competitiveness [Rio Hortega CM 17/00169, JR
   17/00023]; FEDER funds; Mediterranean Diet Foundation; Diputacio de
   Barcelona
FX This work was supported in part by grants from the Institute of Health
   Carlos III (PI15/01114) and Ministry of Innovation, Science and
   Enterprise of the Junta de Andalucia (CTS-8181). ICP is the recipient of
   a postdoctoral grant (Rio Hortega CM 17/00169) and AMG is recipient of a
   Juan Rodes grant (JR 17/00023) from the Spanish Ministry of Economy and
   Competitiveness. This study has been co-funded by FEDER funds. This
   article is published as part of a supplement sponsored by the
   Mediterranean Diet Foundation and the Diputacio de Barcelona.
CR Adlerberth I, 2009, ACTA PAEDIATR, V98, P229, DOI 10.1111/j.1651-2227.2008.01060.x
   Ajslev TA, 2011, INT J OBESITY, V35, P522, DOI 10.1038/ijo.2011.27
   Allin KH, 2015, EUR J ENDOCRINOL, V172, pR167, DOI 10.1530/EJE-14-0874
   Andersson AF, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0002836
   Backhed F, 2004, P NATL ACAD SCI USA, V101, P15718, DOI 10.1073/pnas.0407076101
   Backhed F, 2007, P NATL ACAD SCI USA, V104, P979, DOI 10.1073/pnas.0605374104
   Beck-Nielsen H, 2003, BEST PRACT RES CL EN, V17, P445, DOI 10.1016/S1521-690X(03)00041-1
   Benson AK, 2010, P NATL ACAD SCI USA, V107, P18933, DOI 10.1073/pnas.1007028107
   Bik EM, 2009, NUTR REV, V67, pS164, DOI 10.1111/j.1753-4887.2009.00237.x
   Burcelin R, 2012, SEMIN IMMUNOL, V24, P67, DOI 10.1016/j.smim.2011.11.011
   Burke C, 2011, P NATL ACAD SCI USA, V108, P14288, DOI 10.1073/pnas.1101591108
   Cani PD, 2007, DIABETOLOGIA, V50, P2374, DOI 10.1007/s00125-007-0791-0
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Cani PD, 2009, CURR PHARM DESIGN, V15, P1546, DOI 10.2174/138161209788168164
   Chow J, 2010, ADV IMMUNOL, V107, P243, DOI [10.1016/S0065-2776(10)07001-X, 10.1016/B978-0-12-381300-8.00008-3]
   Claesson MJ, 2011, P NATL ACAD SCI USA, V108, P4586, DOI 10.1073/pnas.1000097107
   Costello EK, 2009, SCIENCE, V326, P1694, DOI 10.1126/science.1177486
   Dao MC, 2016, GUT, V65, P426, DOI 10.1136/gutjnl-2014-308778
   De Filippo C, 2010, P NATL ACAD SCI USA, V107, P14691, DOI 10.1073/pnas.1005963107
   Delzenne NM, 2011, MICROB CELL FACT, V10, DOI 10.1186/1475-2859-10-S1-S10
   Dethlefsen L, 2008, PLOS BIOL, V6, P2383, DOI 10.1371/journal.pbio.0060280
   Dewulf EM, 2011, J NUTR BIOCHEM, V22, P712, DOI 10.1016/j.jnutbio.2010.05.009
   Di Cesare M, 2016, LANCET, V387, P1377, DOI 10.1016/S0140-6736(16)30054-X
   Dominguez-Bello MG, 2010, P NATL ACAD SCI USA, V107, P11971, DOI 10.1073/pnas.1002601107
   Duncan SH, 2008, INT J OBESITY, V32, P1720, DOI 10.1038/ijo.2008.155
   Eckburg PB, 2005, SCIENCE, V308, P1635, DOI 10.1126/science.1110591
   El Kaoutari A, 2013, NAT REV MICROBIOL, V11, P497, DOI 10.1038/nrmicro3050
   Everard A, 2014, REV ENDOCR METAB DIS, V15, P189, DOI 10.1007/s11154-014-9288-6
   Everard A, 2013, BEST PRACT RES CL GA, V27, P73, DOI 10.1016/j.bpg.2013.03.007
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Finlayson A, 2015, WORLD J GASTRO ENDOS, V7, P1103, DOI [10.4253/wjge.v7.i13.1103, 10.4291/wjgp.v6.i4.110]
   Freeland KR, 2010, BRIT J NUTR, V103, P82, DOI 10.1017/S0007114509991462
   Furet JP, 2010, DIABETES, V59, P3049, DOI 10.2337/db10-0253
   Garly ML, 2006, BMJ-BRIT MED J, V333, P1245, DOI 10.1136/bmj.38989.684178.AE
   Guarner F, 2007, NUTR HOSP, V22, P14
   Hansen CHF, 2012, DIABETOLOGIA, V55, P2285, DOI 10.1007/s00125-012-2564-7
   Harakeh SM, 2016, FRONT CELL INFECT MI, V6, DOI 10.3389/fcimb.2016.00095
   Hold GL, 2014, WORLD J GASTROENTERO, V20, P1192, DOI 10.3748/wjg.v20.i5.1192
   Hooper LV, 2001, SCIENCE, V291, P881, DOI 10.1126/science.291.5505.881
   Jacquemont S, 2011, NATURE, V478, P97, DOI 10.1038/nature10406
   Jimenez E, 2008, RES MICROBIOL, V159, P187, DOI 10.1016/j.resmic.2007.12.007
   Jumpertz R, 2011, AM J CLIN NUTR, V94, P58, DOI 10.3945/ajcn.110.010132
   Kalliomaki M, 2008, AM J CLIN NUTR, V87, P534, DOI 10.1093/ajcn/87.3.534
   Kallus SJ, 2012, J CLIN GASTROENTEROL, V46, P16, DOI 10.1097/MCG.0b013e31823711fd
   Klindworth Anna, 2013, Nucleic Acids Res, V41, pe1, DOI 10.1093/nar/gks808
   Kong LC, 2013, AM J CLIN NUTR, V98, P16, DOI 10.3945/ajcn.113.058743
   Kuwahara A, 2014, FRONT ENDOCRINOL, V5, DOI 10.3389/fendo.2014.00144
   Le Huerou-Luron I, 2010, NUTR RES REV, V23, P23, DOI 10.1017/S0954422410000065
   Ley RE, 2005, P NATL ACAD SCI USA, V102, P11070, DOI 10.1073/pnas.0504978102
   Ley RE, 2006, NATURE, V444, P1022, DOI 10.1038/4441022a
   Ley RE, 2010, CURR OPIN GASTROEN, V26, P5, DOI 10.1097/MOG.0b013e328333d751
   Liou AP, 2013, SCI TRANSL MED, V5, DOI 10.1126/scitranslmed.3005687
   Lozupone CA, 2012, NATURE, V489, P220, DOI 10.1038/nature11550
   Luoto R, 2010, INT J OBESITY, V34, P1531, DOI 10.1038/ijo.2010.50
   Martin R, 2003, J PEDIATR-US, V143, P754, DOI 10.1016/j.jpeds.2003.09.028
   Matamoros S, 2013, TRENDS MICROBIOL, V21, P167, DOI 10.1016/j.tim.2012.12.001
   Membrez M, 2008, FASEB J, V22, P2416, DOI 10.1096/fj.07-102723
   Million M, 2013, CLIN MICROBIOL INFEC, V19, P305, DOI 10.1111/1469-0691.12172
   Million M, 2012, INT J OBESITY, V36, P817, DOI 10.1038/ijo.2011.153
   Monira S, 2011, FRONT MICROBIOL, V2, DOI 10.3389/fmicb.2011.00228
   Moran CP, 2014, BEST PRACT RES CL GA, V28, P585, DOI 10.1016/j.bpg.2014.07.005
   Muccioli GG, 2010, MOL SYST BIOL, V6, DOI 10.1038/msb.2010.46
   Murphy R, 2014, INT J OBESITY, V38, P1115, DOI 10.1038/ijo.2013.218
   Musso G, 2010, DIABETES CARE, V33, P2277, DOI 10.2337/dc10-0556
   Nadal I, 2009, INT J OBESITY, V33, P758, DOI 10.1038/ijo.2008.260
   Neyrinck AM, 2010, CURR OPIN CLIN NUTR, V13, P722, DOI 10.1097/MCO.0b013e32833ec3fb
   Palau-Rodriguez M, 2015, FRONT MICROBIOL, V6, DOI [10.3339/fmicb.2075.07751, 10.3389/fmicb.2015.01151]
   Palmer C, 2007, PLOS BIOL, V5, P1556, DOI 10.1371/journal.pbio.0050177
   Parnell JA, 2009, AM J CLIN NUTR, V89, P1751, DOI 10.3945/ajcn.2009.27465
   Peterson J, 2009, GENOME RES, V19, P2317, DOI 10.1101/gr.096651.109
   Qin JJ, 2010, NATURE, V464, P59, DOI 10.1038/nature08821
   Robinson CJ, 2010, MICROBIOL MOL BIOL R, V74, P453, DOI 10.1128/MMBR.00014-10
   Santacruz A, 2009, OBESITY, V17, P1906, DOI 10.1038/oby.2009.112
   Schwiertz A, 2010, OBESITY, V18, P190, DOI 10.1038/oby.2009.167
   Shen W, 2014, J NUTR BIOCHEM, V25, P270, DOI 10.1016/j.jnutbio.2013.09.009
   Simansky KJ, 1996, BEHAV BRAIN RES, V73, P37, DOI 10.1016/0166-4328(96)00066-6
   Sullivan A, 2001, Lancet Infect Dis, V1, P101, DOI 10.1016/S1473-3099(01)00066-4
   Tilg H, 2010, J CLIN GASTROENTEROL, V44, pS16, DOI 10.1097/MCG.0b013e3181dd8b64
   Trasande L, 2013, INT J OBESITY, V37, P16, DOI 10.1038/ijo.2012.132
   Trehan I, 2013, NEW ENGL J MED, V368, P425, DOI 10.1056/NEJMoa1202851
   Turnbaugh PJ, 2008, CELL HOST MICROBE, V3, P213, DOI 10.1016/j.chom.2008.02.015
   Turnbaugh PJ, 2007, NATURE, V449, P804, DOI 10.1038/nature06244
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Turnbaugh PJ, 2010, P NATL ACAD SCI USA, V107, P7503, DOI 10.1073/pnas.1002355107
   Turnbaugh PJ, 2009, NATURE, V457, P480, DOI 10.1038/nature07540
   Ubeda C, 2012, TRENDS IMMUNOL, V33, P459, DOI 10.1016/j.it.2012.05.003
   Vaishampayan PA, 2010, GENOME BIOL EVOL, V2, P53, DOI 10.1093/gbe/evp057
   Voreades N, 2014, FRONT MICROBIOL, V5, DOI 10.3389/fmicb.2014.00494
   Walsh CJ, 2014, FEBS LETT, V588, P4120, DOI 10.1016/j.febslet.2014.03.035
   Wu GD, 2011, SCIENCE, V334, P105, DOI 10.1126/science.1208344
   Xiao SM, 2014, FEMS MICROBIOL ECOL, V87, P303, DOI 10.1111/1574-6941.12250
   Xiong T, 2020, SENSOR ACTUAT B-CHEM, V304, DOI [10.1126/scitranslmed.3009124, 10.1016/j.snb.2019.127310]
   Xiong YM, 2004, P NATL ACAD SCI USA, V101, P1045, DOI 10.1073/pnas.2637002100
   Yadav H, 2013, J BIOL CHEM, V288, P25088, DOI 10.1074/jbc.M113.452516
   Zhang HS, 2009, P NATL ACAD SCI USA, V106, P2365, DOI 10.1073/pnas.0812600106
   Zhou J, 2008, AM J PHYSIOL-ENDOC M, V295, pE1160, DOI 10.1152/ajpendo.90637.2008
   Zhu H, 2009, BEHAV BRAIN RES, V196, P200, DOI 10.1016/j.bbr.2008.08.039
NR 97
TC 67
Z9 70
U1 4
U2 39
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0954-3007
EI 1476-5640
J9 EUR J CLIN NUTR
JI Eur. J. Clin. Nutr.
PY 2019
VL 72
SU S
BP 26
EP 37
DI 10.1038/s41430-018-0306-8
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Nutrition & Dietetics
GA JC2ML
UT WOS:000489111000004
PM 30487562
DA 2023-06-08
ER

PT J
AU Pan, T
   Zheng, SJ
   Zheng, WW
   Shi, C
   Ning, K
   Zhang, QH
   Xie, YB
   Xiang, HY
   Xie, QH
AF Pan, Tong
   Zheng, Shujun
   Zheng, Weiwei
   Shi, Chao
   Ning, Ke
   Zhang, Qinghui
   Xie, Yanbo
   Xiang, Hongyu
   Xie, Qiuhong
TI Christensenella regulated by Huang-Qi-Ling-Hua-San is a key factor by
   which to improve type 2 diabetes
SO FRONTIERS IN MICROBIOLOGY
LA English
DT Article
DE traditional Chinese medicine; gut microbiota; type 2 diabetes; FMT;
   Christensenella; metabolomics
ID FECAL MICROBIOTA TRANSPLANTATION; CHAIN AMINO-ACIDS; GUT MICROBIOTA;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; OBESITY; MECHANISMS; METFORMIN;
   GLUCOSE
AB There is a lot of evidence that oral hypoglycemic drugs work by affecting gut microbes, but the key strains responsible for this effect are not well known. Huang-Qi-Ling-Hua-San (HQLHS), composed of Astragalus Membranaceus, Ganoderma lucidum, Inonotus obliquus, and Momordica charantia L., is a specially designed Chinese medicine formula to treat type 2 diabetes (T2D). In this study, a mouse model of T2D induced by high-fat diet and streptozotocin was used to explore the mechanism of HQLHS in improving hyperglycemia and hyperlipidemia through multiple rounds of animal experiments, such as HQLHS feeding, fecal microbiota transplantation (FMT), and live bacteria feeding, so as to explore the potential target intestinal flora in its hypoglycemic effect. Results show that such specific taxa as Bifidobacterium, Turicibacter, Alistipes, Romboutsia, and Christensenella were identified to be preferably enriched by HQLHS and then assumed to be the target microbes. Herein, FMT was used to test if the upregulated beneficial bacteria by HQLHS play a therapeutic role. The strain Christensenella minuta DSM 22607 and the strain Christensenella timonensis DSM 102800 were selected to test the beneficial effect of Christensenella taxa on T2D. Diabetic animals supplemented with these strains showed the improvement in blood glucose and lipid metabolism, the promotion of GLP-1 secretion, the increase in antioxidant capacity, the inhibition of hepatic gluconeogenesis, the suppression of intestinal glucose absorption, the enhancement of intestinal barrier, reduced LPS-induced inflammation, and the reduction of branched amino acids (BCAAs) content in the liver. Overall, these data demonstrate that Christensenella plays a beneficial role in T2D and is a target for the action of HQLHS therapy.
C1 [Pan, Tong; Zheng, Shujun; Zheng, Weiwei; Shi, Chao; Ning, Ke; Zhang, Qinghui; Xiang, Hongyu; Xie, Qiuhong] Jilin Univ, Sch Life Sci, Natl Engn Lab AIDS Vaccine, Changchun, Peoples R China.
   [Pan, Tong; Zheng, Shujun; Zheng, Weiwei; Shi, Chao; Ning, Ke; Zhang, Qinghui; Xiang, Hongyu; Xie, Qiuhong] Jilin Univ, Sch Life Sci, Changchun, Peoples R China.
   [Xie, Yanbo] Jilin Acad Agr Sci, Jilin Prov Key Lab Agr Biotechnol, Changchun, Peoples R China.
   [Xiang, Hongyu; Xie, Qiuhong] Jilin Univ, Sch Life Sci, Key Lab Mol Enzymol & Engn Minist Educ, Changchun, Peoples R China.
   [Xiang, Hongyu; Xie, Qiuhong] Jilin Univ, Inst Changbai Mt Resource & Hlth, Fusong, Peoples R China.
C3 Jilin University; Jilin University; Jilin Academy of Agricultural
   Sciences; Jilin University; Jilin University
RP Xiang, HY; Xie, QH (通讯作者)，Jilin Univ, Sch Life Sci, Natl Engn Lab AIDS Vaccine, Changchun, Peoples R China.; Xiang, HY; Xie, QH (通讯作者)，Jilin Univ, Sch Life Sci, Changchun, Peoples R China.; Xie, YB (通讯作者)，Jilin Acad Agr Sci, Jilin Prov Key Lab Agr Biotechnol, Changchun, Peoples R China.; Xiang, HY; Xie, QH (通讯作者)，Jilin Univ, Sch Life Sci, Key Lab Mol Enzymol & Engn Minist Educ, Changchun, Peoples R China.; Xiang, HY; Xie, QH (通讯作者)，Jilin Univ, Inst Changbai Mt Resource & Hlth, Fusong, Peoples R China.
EM hyxiang@jlu.edu.cn; qhxie@jlu.edu.cn; xieyanbo6736@outlook.com
FU Department of Science and Technology of Jilin Province; 
   [20200708072YY];  [20210401122YY]
FX This work was supported by the Department of Science and Technology of
   Jilin Province under (grant nos. 20200708072YY and 20210401122YY).
CR Al-Aubaidy HA, 2011, EUR J ENDOCRINOL, V164, P899, DOI 10.1530/EJE-11-0053
   Archer AC, 2021, PROBIOTICS ANTIMICRO, V13, P1068, DOI 10.1007/s12602-021-09744-0
   Bhatti JS, 2022, FREE RADICAL BIO MED, V184, P114, DOI 10.1016/j.freeradbiomed.2022.03.019
   Brock RW, 2007, MICROCIRCULATION, V14, P339, DOI 10.1080/10739680701282986
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Chen BT, 2021, J FUNCT FOODS, V85, DOI 10.1016/j.jff.2021.104629
   Chen MY, 2020, INT J BIOL MACROMOL, V155, P890, DOI 10.1016/j.ijbiomac.2019.11.047
   Connelly MA, 2017, METAB SYNDR RELAT D, V15, P183, DOI 10.1089/met.2016.0145
   Crommen S, 2018, GENES-BASEL, V9, DOI 10.3390/genes9010010
   Dejean G, 2021, MICROORGANISMS, V9, DOI 10.3390/microorganisms9061252
   Depommier C, 2020, GUT MICROBES, V11, P1231, DOI 10.1080/19490976.2020.1737307
   Feng WW, 2019, PHARMACOL RES, V142, P176, DOI 10.1016/j.phrs.2019.02.024
   Fraga CG, 2019, FOOD FUNCT, V10, P514, DOI [10.1039/C8FO01997E, 10.1039/c8fo01997e]
   Fung TC, 2019, NAT MICROBIOL, V4, P2064, DOI 10.1038/s41564-019-0540-4
   Gao H, 2019, FOOD RES INT, V121, P367, DOI 10.1016/j.foodres.2019.03.055
   Gavrilova O, 2003, J BIOL CHEM, V278, P34268, DOI 10.1074/jbc.M300043200
   Gong X, 2020, PHARMACOL RES, V157, DOI 10.1016/j.phrs.2020.104824
   Goodrich JK, 2014, CELL, V159, P789, DOI 10.1016/j.cell.2014.09.053
   Gupta S, 2016, THER ADV GASTROENTER, V9, P229, DOI 10.1177/1756283X15607414
   Gurung M, 2020, EBIOMEDICINE, V51, DOI 10.1016/j.ebiom.2019.11.051
   Hampe CS, 2017, ENDOCRINE, V58, P207, DOI 10.1007/s12020-017-1433-z
   Hanninen A, 2018, GUT, V67, P1445, DOI 10.1136/gutjnl-2017-314508
   Hanssen NMJ, 2021, CELL METAB, V33, P1098, DOI 10.1016/j.cmet.2021.05.005
   Kahn SE, 2006, NATURE, V444, P840, DOI 10.1038/nature05482
   Lee JS, 2022, BIOTECHNOL J, V17, DOI 10.1002/biot.202100397
   Leylabadlo HE, 2020, INFECT GENET EVOL, V81, DOI 10.1016/j.meegid.2020.104268
   Li X, 2020, PEERJ, V8, DOI 10.7717/peerj.9591
   Li YB, 2020, FRONT IMMUNOL, V11, DOI 10.3389/fimmu.2020.551449
   Liu GM, 2018, INT J BIOL MACROMOL, V115, P711, DOI 10.1016/j.ijbiomac.2018.04.127
   Liu XM, 2022, NAT GENET, V54, P52, DOI 10.1038/s41588-021-00968-y
   Liu YM, 2019, CARBOHYD POLYM, V205, P500, DOI 10.1016/j.carbpol.2018.10.041
   Mazier W, 2021, CELLS-BASEL, V10, DOI 10.3390/cells10040823
   Mirmiranpour H, 2013, J DIABETES COMPLICAT, V27, P501, DOI 10.1016/j.jdiacomp.2013.05.006
   Mora-Ortiz M, 2019, METABOLOMICS, V15, DOI 10.1007/s11306-019-1548-8
   Nie QX, 2019, CRIT REV FOOD SCI, V59, P848, DOI 10.1080/10408398.2018.1536646
   Proctor L, 2019, NATURE, V569, P623, DOI 10.1038/d41586-019-01654-0
   Qi QB, 2022, GUT, V71, P1095, DOI 10.1136/gutjnl-2021-324053
   Qin WY, 2021, COMPR REV FOOD SCI F, V20, P5173, DOI 10.1111/1541-4337.12808
   Saeedi P, 2019, DIABETES RES CLIN PR, V157, DOI 10.1016/j.diabres.2019.107843
   Sanna S, 2019, NAT GENET, V51, P600, DOI 10.1038/s41588-019-0350-x
   Schmitt CC, 2017, MOL METAB, V6, P61, DOI 10.1016/j.molmet.2016.10.008
   Song JX, 2022, BIOENGINEERED, V13, P8334, DOI 10.1080/21655979.2022.2051858
   Stumvoll M, 2005, LANCET, V365, P1333, DOI 10.1016/S0140-6736(05)61032-X
   Tahrani AA, 2016, NAT REV ENDOCRINOL, V12, P566, DOI 10.1038/nrendo.2016.86
   Tao YW, 2020, J TRANSL MED, V18, DOI 10.1186/s12967-020-02213-2
   Tasci SK, 2018, J VET RES, V62, P237, DOI 10.2478/jvetres-2018-0033
   Wang JK, 2020, BIOMED PHARMACOTHER, V121, DOI 10.1016/j.biopha.2019.109565
   Wang YB, 2020, APPL MICROBIOL BIOT, V104, P335, DOI 10.1007/s00253-019-10259-6
   Waters JL, 2019, BMC BIOL, V17, DOI 10.1186/s12915-019-0699-4
   Wei ZH, 2020, OXID MED CELL LONGEV, V2020, DOI 10.1155/2020/2375676
   Wu L, 2022, FOOD SCI TECH-BRAZIL, V42, DOI 10.1590/fst.00121
   Wu X, 2020, PHARMACOL RES, V158, DOI 10.1016/j.phrs.2020.104937
   Xiang JY, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.822429
   Xu J, 2017, MED RES REV, V37, P1140, DOI 10.1002/med.21431
   Yang YY, 2018, MICROB PATHOGENESIS, V125, P411, DOI 10.1016/j.micpath.2018.10.005
   Yde CC, 2021, PLOS ONE, V16, DOI 10.1371/journal.pone.0260765
   Yu DY, 2021, CELL METAB, V33, P905, DOI 10.1016/j.cmet.2021.03.025
   Yu J, 2020, ACS OMEGA, V5, P16690, DOI 10.1021/acsomega.0c01566
   Zeng Z, 2021, FOOD FUNCT, V12, P6809, DOI [10.1039/D1FO00515D, 10.1039/d1fo00515d]
   Zhang BX, 2019, EVID-BASED COMPL ALT, V2019, DOI 10.1155/2019/2634898
   Zhang Q, 2020, DIABET METAB SYND OB, V13, P5003, DOI 10.2147/DMSO.S286430
   Zheng JP, 2020, J ETHNOPHARMACOL, V248, DOI 10.1016/j.jep.2019.112330
NR 62
TC 1
Z9 1
U1 16
U2 26
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1664-302X
J9 FRONT MICROBIOL
JI Front. Microbiol.
PD OCT 12
PY 2022
VL 13
AR 1022403
DI 10.3389/fmicb.2022.1022403
PG 16
WC Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology
GA 5U9ZH
UT WOS:000876897900001
PM 36312936
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Sheng, Y
   Zheng, SJ
   Ma, TS
   Zhang, CH
   Ou, XQ
   He, XY
   Xu, WT
   Huang, KL
AF Sheng, Yao
   Zheng, Shujuan
   Ma, Tianshi
   Zhang, Chuanhai
   Ou, Xiaoqun
   He, Xiaoyun
   Xu, Wentao
   Huang, Kunlun
TI Mulberry leaf alleviates streptozotocin-induced diabetic rats by
   attenuating NEFA signaling and modulating intestinal microflora
SO SCIENTIFIC REPORTS
LA English
DT Article
ID FREE FATTY-ACID; MORUS-ALBA L.; INSULIN-RESISTANCE; GUT MICROBIOTA;
   GLUCOSE; OBESE; METFORMIN; MECHANISM; GLIBENCLAMIDE; INFLAMMATION
AB Improvement of hyperglycemia through dietotherapy/herbal remedy is an effective approach to treating diabetes. In this study, mulberry leaf, famous for silkworm's special food and therapeutic value without any side effects, alleviated diabetes by attenuating NEFA signaling and modulating intestinal microflora. Mulberry leaf treatment significantly reduce fasting blood-glucose and HbA1c, ameliorate the blood lipid profile and improve insulin resistance in streptozotocin-induced diabetic rats. Mechanistically, we found that mulberry leaf inhibited NEFA signaling by reducing downstream signaling in the NEFA pathway, further verified by reduced PKC and improved cellular energy homeostasis based on restored expression of PGC-1 alpha, AK2, OXPHOS and adiponectin. Mulberry leaf treatment also restored the phyla Bacteroidetes and Proteobacteria and class Clostridia, which were associated with insulin resistance and diabetes. Our findings reveal that mulberry leaf is an edible with therapeutic potential for diabetes and may provide a novel dietotherapy/herbal remedy to the treatment of diabetes.
C1 [Sheng, Yao; Zheng, Shujuan; Ma, Tianshi; Zhang, Chuanhai; Ou, Xiaoqun; He, Xiaoyun; Xu, Wentao; Huang, Kunlun] China Agr Univ, Coll Food Sci & Nutr Engn, Beijing Adv Innovat Ctr Food Nutr & Human Hlth, Beijing 100083, Peoples R China.
   [He, Xiaoyun; Xu, Wentao; Huang, Kunlun] Minist Agr, Key Lab Safety Assessment Genetically Modified Or, Beijing 100083, Peoples R China.
C3 China Agricultural University; Ministry of Agriculture & Rural Affairs
RP Huang, KL (通讯作者)，China Agr Univ, Coll Food Sci & Nutr Engn, Beijing Adv Innovat Ctr Food Nutr & Human Hlth, Beijing 100083, Peoples R China.; Huang, KL (通讯作者)，Minist Agr, Key Lab Safety Assessment Genetically Modified Or, Beijing 100083, Peoples R China.
EM foodsafety66@cau.edu.cn
RI Zhang, Chuanhai/O-3137-2018; Zhang, Chuanhai/N-6655-2019
OI Zhang, Chuanhai/0000-0001-7644-2436; Zhang,
   Chuanhai/0000-0001-7644-2436; Kunlun, Huang/0000-0002-2350-5859;
   Shujuan, Zheng/0000-0001-6545-0748
FU Genetically Modified Organisms Breeding Major Projects of P.R. China
   [2016ZX08011-005]
FX This work was supported by grants from the Genetically Modified
   Organisms Breeding Major Projects of P.R. China (2016ZX08011-005).
CR Arimatsu K, 2014, SCI REP-UK, V4, DOI 10.1038/srep04828
   Asano N, 2001, J AGR FOOD CHEM, V49, P4208, DOI 10.1021/jf010567e
   Barelli G., 1999, U. S. Patent, Patent No. [5,922,769, 5922769]
   BECKNIELSEN H, 1979, ACTA ENDOCRINOL-COP, V90, P451, DOI 10.1530/acta.0.0900451
   Boden G, 1997, DIABETES, V46, P3, DOI 10.2337/diabetes.46.1.3
   Cani PD, 2008, DIABETOLOGIA, V51, pS34
   Cani PD, 2009, GUT, V58, P1091, DOI 10.1136/gut.2008.165886
   Carlson R. W., 2001, JAMA-J AM MED ASSOC, V253, P84
   Carvalho-Martini Mirian, 2006, Research Communications in Molecular Pathology and Pharmacology, V119, P115
   Collier CA, 2006, AM J PHYSIOL-ENDOC M, V291, pE182, DOI 10.1152/ajpendo.00272.2005
   De Smet PAGM, 2002, NEW ENGL J MED, V347, P2046, DOI 10.1056/NEJMra020398
   Dobbins RL, 1998, J CLIN INVEST, V101, P2370, DOI 10.1172/JCI1813
   Dugo P, 2009, J SEP SCI, V32, P3627, DOI 10.1002/jssc.200900348
   Edgar RC, 2013, NAT METHODS, V10, P996, DOI [10.1038/nmeth.2604, 10.1038/NMETH.2604]
   Gil-Campos M, 2011, NUTR METAB CARDIOVAS, V21, P62, DOI 10.1016/j.numecd.2009.07.003
   Gonzalez-Ortiz M, 2009, J DIABETES COMPLICAT, V23, P376, DOI 10.1016/j.jdiacomp.2008.09.002
   Greetham HL, 2004, ANAEROBE, V10, P301, DOI 10.1016/j.anaerobe.2004.06.004
   Guo MZ, 2014, TOXICOL SCI, V141, P314, DOI 10.1093/toxsci/kfu128
   GUO Z, 2016, SCI REP UK, V6
   IDF, 2016, INT DIAB FED, P9
   Jouad H, 2001, J ETHNOPHARMACOL, V77, P175, DOI 10.1016/S0378-8741(01)00289-6
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Katsube T, 2006, FOOD CHEM, V97, P25, DOI 10.1016/j.foodchem.2005.03.019
   Katsube T, 2009, FOOD CHEM, V113, P964, DOI 10.1016/j.foodchem.2008.08.041
   Khosravi Y, 2015, SCI REP-UK, V5, DOI 10.1038/srep08731
   Kimura T, 2004, J AGR FOOD CHEM, V52, P1415, DOI 10.1021/jf0306901
   Kimura T, 2007, J AGR FOOD CHEM, V55, P5869, DOI 10.1021/jf062680g
   Kirpichnikov D, 2002, ANN INTERN MED, V137, P25, DOI 10.7326/0003-4819-137-1-200207020-00009
   Kitabchi AE, 2009, DIABETES CARE, V32, P1335, DOI 10.2337/dc09-9032
   Kohler C, 1999, FEBS LETT, V447, P10, DOI 10.1016/S0014-5793(99)00251-3
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Leung N, 2004, DIABETOLOGIA, V47, P204, DOI 10.1007/s00125-003-1301-7
   Ley RE, 2005, P NATL ACAD SCI USA, V102, P11070, DOI 10.1073/pnas.0504978102
   Ley RE, 2006, NATURE, V444, P1022, DOI 10.1038/4441022a
   Li YG, 2011, J ETHNOPHARMACOL, V134, P961, DOI 10.1016/j.jep.2011.02.009
   Marini C, 2016, SCI REP-UK, V6, DOI 10.1038/srep19569
   Matsumoto M, 2012, SCI REP-UK, V2, DOI 10.1038/srep00233
   McKimmie RL, 2008, AM J GASTROENTEROL, V103, P3029, DOI 10.1111/j.1572-0241.2008.02188.x
   Mori T, 2014, SCI REP-UK, V4, DOI 10.1038/srep04895
   Namaboot J, 2009, NUTR RES, V29, P602, DOI 10.1016/j.nutres.2009.06.002
   Naowaboot J, 2009, PLANT FOOD HUM NUTR, V64, P116, DOI 10.1007/s11130-009-0112-5
   Ota R, 2007, DIABETES, V56, pA677
   Patti ME, 2003, P NATL ACAD SCI USA, V100, P8466, DOI 10.1073/pnas.1032913100
   Paulson JN, 2013, NAT METHODS, V10, P1200, DOI [10.1038/NMETH.2658, 10.1038/nmeth.2658]
   Poroyko VA, 2016, SCI REP-UK, V6, DOI 10.1038/srep35405
   Prentki M, 2002, DIABETES, V51, pS405, DOI 10.2337/diabetes.51.2007.S405
   REAVEN GM, 1988, DIABETES, V37, P1020, DOI 10.2337/diabetes.37.8.1020
   Reddy NL, 2015, CLIN ENDOCRINOL, V82, P831, DOI 10.1111/cen.12652
   Reed MJ, 2000, METABOLISM, V49, P1390, DOI 10.1053/meta.2000.17721
   REEVES PG, 1993, J NUTR, V123, P1939, DOI 10.1093/jn/123.11.1939
   Rena G, 2013, DIABETOLOGIA, V56, P1898, DOI 10.1007/s00125-013-2991-0
   Roden M, 1996, J CLIN INVEST, V97, P2859, DOI 10.1172/JCI118742
   Roden M, 2000, DIABETES, V49, P701, DOI 10.2337/diabetes.49.5.701
   Rosen ED, 2006, NATURE, V444, P847, DOI 10.1038/nature05483
   Santomauro ATMG, 1999, DIABETES, V48, P1836, DOI 10.2337/diabetes.48.9.1836
   Segata N, 2011, GENOME BIOL, V12, DOI 10.1186/gb-2011-12-6-r60
   Sepp E, 2014, MICROB ECOL HEALTH D, V25, DOI 10.3402/mehd.v25.22857
   Serrano-Martin X, 2006, ANTIMICROB AGENTS CH, V50, P4214, DOI 10.1128/AAC.00617-06
   Shi YX, 2016, SCI REP-UK, V6, DOI 10.1038/srep24744
   Shulman GI, 2000, J CLIN INVEST, V106, P171, DOI 10.1172/JCI10583
   Simha V, 2006, CURR OPIN LIPIDOL, V17, P162, DOI 10.1097/01.mol.0000217898.52197.18
   Tosi F, 2003, METABOLISM, V52, P862, DOI 10.1016/S0026-0495(03)00101-X
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Turnbaugh PJ, 2009, NATURE, V457, P480, DOI 10.1038/nature07540
   Ukkola O, 2002, J MOL MED, V80, P696, DOI 10.1007/s00109-002-0378-7
   Venkatesh KP, 2008, J MED PLANTS RES, V2, P271
   Wang C, 2016, SCI REP-UK, V6, DOI 10.1038/srep20032
   Wang GY, 2010, PHYS BIOL, V7, DOI 10.1088/1478-3975/7/4/046015
   Wang Q, 2007, APPL ENVIRON MICROB, V73, P5261, DOI 10.1128/AEM.00062-07
   Wu CH, 2010, J AGR FOOD CHEM, V58, P7075, DOI 10.1021/jf101415v
   Wu XK, 2010, CURR MICROBIOL, V61, P69, DOI 10.1007/s00284-010-9582-9
   Zhang X, 2012, PLOS ONE, V7, DOI [10.1371/journal.pone.0040320, 10.1371/journal.pone.0042529]
   Zhou GC, 2001, J CLIN INVEST, V108, P1167, DOI 10.1172/JCI200113505
NR 73
TC 29
Z9 31
U1 1
U2 37
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD SEP 21
PY 2017
VL 7
AR 12041
DI 10.1038/s41598-017-12245-2
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA FH8BJ
UT WOS:000411416500001
PM 28935866
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Jafari, M
   Arabit, JGJ
   Courville, R
   Kiani, D
   Chaston, JM
   Nguyen, CD
   Jena, N
   Liu, ZY
   Tata, P
   Van Etten, RA
AF Jafari, Mahtab
   Arabit, Jasmin Grace Juanson
   Courville, Robert
   Kiani, Dara
   Chaston, John M.
   Nguyen, Cindy Duy
   Jena, Nilamani
   Liu, Zhong-Ying
   Tata, Prasanthi
   Van Etten, Richard A.
TI The impact of Rhodiola rosea on biomarkers of diabetes, inflammation,
   and microbiota in a leptin receptor-knockout mouse model
SO SCIENTIFIC REPORTS
LA English
DT Article
ID GUT MICROBIOTA; GLUCOSE-TOLERANCE; ADIPOSE-TISSUE; EXTRACT SHR-5; OBESE
   MICE; LIFE-SPAN; SULFONYLUREA; IMPROVEMENT; NORFLOXACIN; METABOLISM
AB Type 2 diabetes is the most prevalent endocrine disease in the world, and recently the gut microbiota have become a potential target for its management. Recent studies have illustrated that this disease may predispose individuals to certain microbiome compositions, and treatments like metformin have been shown to change gut microbiota and their associated metabolic pathways. However, given the limitations and side effects associated with pharmaceuticals currently being used for therapy of diabetes, there is a significant need for alternative treatments. In this study, we investigated the effects of a root extract from Rhodiola rosea in a Leptin receptor knockout (db/db) mouse model of type 2 diabetes. Our previous work showed that Rhodiola rosea had anti-inflammatory and gut microbiome-modulating properties, while extending lifespan in several animal models. In this study, treatment with Rhodiola rosea improved fasting blood glucose levels, altered the response to exogenous insulin, and decreased circulating lipopolysaccharide and hepatic C-reactive protein transcript levels. We hypothesize that these changes may in part reflect the modulation of the microbiota, resulting in improved gut barrier integrity and decreasing the translocation of inflammatory biomolecules into the bloodstream. These findings indicate that Rhodiola rosea is an attractive candidate for further research in the management of type 2 diabetes.
C1 [Jafari, Mahtab; Arabit, Jasmin Grace Juanson; Courville, Robert; Nguyen, Cindy Duy] Univ Calif Irvine, Dept Pharmaceut Sci, Irvine, CA 92697 USA.
   [Kiani, Dara] Univ Illinois, Coll Med, Dept Microbiol & Immunol, Chicago, IL 60612 USA.
   [Chaston, John M.] Brigham Young Univ, Dept Plant & Wildlife Sci, Provo, UT 84602 USA.
   [Jena, Nilamani; Liu, Zhong-Ying; Tata, Prasanthi; Van Etten, Richard A.] Univ Calif Irvine, Dept Med, Irvine, CA 92717 USA.
C3 University of California System; University of California Irvine;
   University of Illinois System; University of Illinois Chicago;
   University of Illinois Chicago Hospital; Brigham Young University;
   University of California System; University of California Irvine
RP Jafari, M (通讯作者)，Univ Calif Irvine, Dept Pharmaceut Sci, Irvine, CA 92697 USA.
EM mjafari@uci.edu
FU UCI Microbiome Center; UCI School of Medicine-Pharmaceutical Scienes
   Collaborative Research Funds
FX We would like to acknowledge the UCI Microbiome Center for granting a
   Pilot Award, providing consulting on study design and supporting the
   generation of the microbiome amplicon sequence data. We would like to
   thank Ms. Claudia Weihe, Dr. Jennifer Martiny and Dr. Katrine Whiteson
   from the UCI Microbiome Center. We thank the UCI School of
   Medicine-Pharmaceutical Scienes Collaborative Research Funds and Mr. and
   Mrs. John P. and Lois C. Wareham for providing funding for this work.
CR Abe M, 2011, CURR DRUG METAB, V12, P57, DOI 10.2174/138920011794520053
   Amer Diabet Assoc, 2014, DIABETES CARE, V37, pS81, DOI [10.2337/dc13-S067, 10.2337/dc14-S081, 10.2337/dc13-S011, 10.2337/dc10-S062, 10.2337/dc10-S011, 10.2337/dc11-S062, 10.2337/dc12-s064, 10.2337/dc11-S011]
   Beguinot Francesco, 2012, Methods Mol Biol, V933, P219, DOI 10.1007/978-1-62703-068-7_14
   Berg AH, 2005, CIRC RES, V96, P939, DOI 10.1161/01.RES.0000163635.62927.34
   Bogacka I, 2004, DIABETES CARE, V27, P1660, DOI 10.2337/diacare.27.7.1660
   Bokulich NA, 2018, MICROBIOME, V6, DOI 10.1186/s40168-018-0470-z
   Bolyen E, 2019, NAT BIOTECHNOL, V37, P852, DOI 10.1038/s41587-019-0209-9
   Boon-Niermeijer EK, 2000, PHYTOMEDICINE, V7, P389, DOI 10.1016/S0944-7113(00)80060-4
   BRAY GA, 1979, PHYSIOL REV, V59, P719, DOI 10.1152/physrev.1979.59.3.719
   Brun P, 2007, AM J PHYSIOL-GASTR L, V292, pG518, DOI 10.1152/ajpgi.00024.2006
   Burke SJ, 2017, J DIABETES RES, V2017, DOI 10.1155/2017/8503754
   Callahan BJ, 2016, NAT METHODS, V13, P581, DOI [10.1038/NMETH.3869, 10.1038/nmeth.3869]
   Cani PD, 2009, GUT, V58, P1091, DOI 10.1136/gut.2008.165886
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   Chen C, 2016, BIOGERONTOLOGY, V17, P373, DOI 10.1007/s10522-015-9622-8
   Chen WS, 2009, MOL CELL BIOL, V29, P3151, DOI 10.1128/MCB.01792-08
   Chiasson JL, 2003, JAMA-J AM MED ASSOC, V290, P486, DOI 10.1001/jama.290.4.486
   Chou CJ, 2008, NESTLE NUTR WORKS SE, V62, P127, DOI 10.1159/000146256
   Chuengsamarn S, 2012, DIABETES CARE, V35, P2121, DOI 10.2337/dc12-0116
   Darbinyan V, 2007, NORD J PSYCHIAT, V61, P343, DOI 10.1080/08039480701643290
   Deciga-Campos M, 2016, DRUG DEVELOP RES, V77, P29, DOI 10.1002/ddr.21289
   Fantuzzi G, 2005, J ALLERGY CLIN IMMUN, V115, P911, DOI 10.1016/j.jaci.2005.02.023
   Geurts L, 2011, FRONT MICROBIOL, V2, DOI 10.3389/fmicb.2011.00149
   Gregor MF, 2011, ANNU REV IMMUNOL, V29, P415, DOI 10.1146/annurev-immunol-031210-101322
   Hall M, 2018, METHODS MOL BIOL, V1849, P113, DOI 10.1007/978-1-4939-8728-3_8
   Marin-Penalver JJ, 2016, WORLD J DIABETES, V7, P354, DOI 10.4239/wjd.v7.i17.354
   Jumpertz R, 2011, AM J CLIN NUTR, V94, P58, DOI 10.3945/ajcn.110.010132
   Kalliomaki M, 2008, AM J CLIN NUTR, V87, P534, DOI 10.1093/ajcn/87.3.534
   Katoh K, 2002, NUCLEIC ACIDS RES, V30, P3059, DOI 10.1093/nar/gkf436
   Kirkham S, 2009, DIABETES OBES METAB, V11, P1100, DOI 10.1111/j.1463-1326.2009.01094.x
   Kirschman LJ, 2019, APPL ENVIRON MICROB, V85, DOI 10.1128/AEM.02147-18
   Kobayashi K, 2000, METABOLISM, V49, P22, DOI 10.1016/S0026-0495(00)90588-2
   Labachyan KE, 2018, GUT PATHOG, V10, DOI 10.1186/s13099-018-0239-8
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Lee Y, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/514049
   Lin XL, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-71908-9
   Liu W, 2017, MOL NUTR FOOD RES, V61, DOI 10.1002/mnfr.201601082
   Lozupone C, 2005, APPL ENVIRON MICROB, V71, P8228, DOI 10.1128/AEM.71.12.8228-8235.2005
   Lozupone CA, 2007, APPL ENVIRON MICROB, V73, P1576, DOI 10.1128/AEM.01996-06
   Maedler K, 2005, J CLIN ENDOCR METAB, V90, P501, DOI 10.1210/jc.2004-0699
   Mambiya M, 2019, FRONT PUBLIC HEALTH, V7, DOI 10.3389/fpubh.2019.00349
   Mandal Siddhartha, 2015, Microbial Ecology in Health and Disease, V26, P27663, DOI 10.3402/mehd.v26.27663
   McDonald D, 2012, ISME J, V6, P610, DOI 10.1038/ismej.2011.139
   Membrez M, 2008, FASEB J, V22, P2416, DOI 10.1096/fj.07-102723
   Murea Mariana, 2012, Rev Diabet Stud, V9, P6, DOI 10.1900/RDS.2012.9.6
   Musso G, 2011, ANNU REV MED, V62, P361, DOI 10.1146/annurev-med-012510-175505
   Niu CS, 2014, BMC COMPLEM ALTERN M, V14, DOI 10.1186/1472-6882-14-20
   Oksanen J., 2020, VEGAN COMMUNITY ECOL
   Olsson EMG, 2009, PLANTA MED, V75, P105, DOI 10.1055/s-0028-1088346
   Peraldi P, 1996, J BIOL CHEM, V271, P13018, DOI 10.1074/jbc.271.22.13018
   Pooja, 2009, PHYTOTHER RES, V23, P1099, DOI 10.1002/ptr.2749
   Price MN, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009490
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Rosenwasser RF, 2013, DIABETES METAB SYNDR, V6, P453, DOI 10.2147/DMSO.S34416
   Schriner SE, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0063886
   Shevtsov VA, 2003, PHYTOMEDICINE, V10, P95, DOI 10.1078/094471103321659780
   Shoelson SE, 2006, J CLIN INVEST, V116, P1793, DOI 10.1172/JCI29069
   Smyth S, 2006, NAT MED, V12, P75, DOI 10.1038/nm0106-75
   Sorenson TJ, 1948, BIOL SKR DAN VID SEL, V5, P1, DOI [DOI 10.1080/00431672.1948.9933503, DOI 10.1234/12345678]
   Sweet MJ, 1996, J LEUKOCYTE BIOL, V60, P8, DOI 10.1002/jlb.60.1.8
   Takahashi A, 2007, DIABETES RES CLIN PR, V77, P343, DOI 10.1016/j.diabres.2006.12.021
   Tartaglia LA, 1995, CELL, V83, P1263, DOI 10.1016/0092-8674(95)90151-5
   Whelan FJ, 2018, METHODS MOL BIOL, V1849, P49, DOI 10.1007/978-1-4939-8728-3_4
   Wiegant FAC, 2009, BIOGERONTOLOGY, V10, P27, DOI 10.1007/s10522-008-9151-9
   Wu XK, 2010, CURR MICROBIOL, V61, P69, DOI 10.1007/s00284-010-9582-9
   Xu HY, 2003, J CLIN INVEST, V112, P1821, DOI 10.1172/JCI200319451
   Yang WY, 2018, DIABETES CARE, V41, P917, DOI 10.2337/dci18-0007
   Yu F, 2019, AGING-US, V11, P10454, DOI 10.18632/aging.102469
   Yuan Y, 2019, FOOD CHEM TOXICOL, V125, P333, DOI 10.1016/j.fct.2019.01.007
NR 71
TC 0
Z9 0
U1 3
U2 5
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JUN 22
PY 2022
VL 12
IS 1
AR 10581
DI 10.1038/s41598-022-14241-7
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 2I2TN
UT WOS:000814836700006
PM 35732671
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Nittayaboon, K
   Leetanaporn, K
   Sangkhathat, S
   Roytrakul, S
   Navakanitworakul, R
AF Nittayaboon, Kesara
   Leetanaporn, Kittinun
   Sangkhathat, Surasak
   Roytrakul, Sittiruk
   Navakanitworakul, Raphatphorn
TI Characterization of Butyrate-Resistant Colorectal Cancer Cell Lines and
   the Cytotoxicity of Anticancer Drugs against These Cells
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Article
ID HUMAN COLON-CANCER; GUT MICROBIOTA; ACQUISITION; MECHANISMS; METFORMIN;
   OUTCOMES; STRESS; ARREST; PCR
AB Colorectal cancer (CRC) is the third most common cancer worldwide. The gut microbiota plays a critical role in homeostasis and carcinogenesis. Butyrate, a short-chain fatty acid produced by the gut microbiota, plays a role in intestinal homeostasis and acts as an anticancer agent by inhibiting growth and inducing apoptosis. However, microbiota studies have revealed an abnormally high abundance of butyrate-producing bacteria in patients with CRC and indicated that it leads to chemoresistance. We characterized butyrate resistance in HCT-116 and PMF-K014 CRC cells after treatment with a maximum butyrate concentration of 3.2 mM. The 50% inhibitory concentration of butyrate was increased in butyrate-resistant (BR) cells compared with that in parental (PT) cells. The mechanism of butyrate resistance was initially investigated by determining the expression of butyrate influx- and drug efflux-related genes. We found the increased expression of influx- and efflux-related genes in BR cells compared with that in PT cells. Proteomic data showed both identical and different proteins in PT and BR cells. Further analysis revealed the crossresistance of HCT-116 cells to metformin and oxaliplatin and that of PMF-K014 cells to 5-fluorouracil. Our findings suggest that the acquisition of butyrate resistance induces the development of chemoresistance in CRC cells, which may play an important role in CRC development, treatment, and metastasis.
C1 [Nittayaboon, Kesara; Leetanaporn, Kittinun; Sangkhathat, Surasak; Navakanitworakul, Raphatphorn] Prince Songkla Univ, Fac Med, Dept Biomed Sci & Biomed Engn, Hat Yai 90110, Songkhla, Thailand.
   [Roytrakul, Sittiruk] Natl Ctr Genet Engn & Biotechnol BIOTEC, Funct Ingredients & Food Innovat Res Grp, Natl Sci & Technol Dev Agcy, Pathum Thani 12120, Thailand.
C3 Prince of Songkla University; National Science & Technology Development
   Agency - Thailand; National Center Genetic Engineering & Biotechnology
   (BIOTEC)
RP Navakanitworakul, R (通讯作者)，Prince Songkla Univ, Fac Med, Dept Biomed Sci & Biomed Engn, Hat Yai 90110, Songkhla, Thailand.
EM kesara.nittayaboon@gmail.com; lkittinun1@gmail.com;
   s.sangkhathat@gmail.com; sittiruk@biotec.or.th;
   nraphatp@medicine.psu.ac.th
RI Leetanaporn, Kittinun/AAX-7502-2020
OI Leetanaporn, Kittinun/0000-0002-7621-4510; Roytrakul,
   Sittiruk/0000-0003-3696-8390; Navakanitworakul,
   Raphatphorn/0000-0001-6408-0079; Sangkhathat,
   Surasak/0000-0003-3622-3233
FU Faculty of Medicine, Prince of Songkla University [REC6337942]; Research
   Center for Cancer Control in Thailand [MEDRC59036]; Graduate
   Scholarship, Faculty of Medicine, Prince of Songkla University
FX The authors would like to thank Editage (https://www.editage.com) for
   the English language review. The research was financially supported by
   the Faculty of Medicine, Prince of Songkla University (REC6337942),
   Research Center for Cancer Control in Thailand (MEDRC59036), and
   Graduate Scholarship, Faculty of Medicine, Prince of Songkla University.
CR Al Hassan M, 2018, ANAL CELL PATHOL, V2018, DOI 10.1155/2018/5917470
   Allenspach EJ, 2002, CANCER BIOL THER, V1, P466, DOI 10.4161/cbt.1.5.159
   Armaghany Tannaz, 2012, Gastrointest Cancer Res, V5, P19
   Baxter NT, 2019, MBIO, V10, DOI [10.1128/mBio.02566-18, 10.1128/mbio.02566-18]
   Bustin SA, 2005, CLIN SCI, V109, P365, DOI 10.1042/CS20050086
   Chang JC, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000004766
   Chowdhury S, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0060299
   Chu DX, 2018, BMC CANCER, V18, DOI 10.1186/s12885-018-4334-5
   Cresci GA, 2010, J GASTROINTEST SURG, V14, P449, DOI 10.1007/s11605-009-1045-x
   Dallas NA, 2009, CANCER RES, V69, P1951, DOI 10.1158/0008-5472.CAN-08-2023
   de Silanes IL, 2004, CANCER RES, V64, P4593, DOI 10.1158/0008-5472.CAN-04-0711
   Duz MB, 2021, MOL BIOL REP, V48, P1393, DOI 10.1007/s11033-021-06167-6
   Duz MB, 2020, MOL BIOL REP, V47, P5431, DOI 10.1007/s11033-020-05633-x
   Friedl P, 2003, NAT REV CANCER, V3, P362, DOI 10.1038/nrc1075
   Gandini S, 2014, CANCER PREV RES, V7, P867, DOI 10.1158/1940-6207.CAPR-13-0424
   Gillet JP, 2004, CANCER RES, V64, P8987, DOI 10.1158/0008-5472.CAN-04-1978
   Hanprasertpong J, 2017, INT J GYNECOL CANCER, V27, P131, DOI 10.1097/IGC.0000000000000855
   He JJ, 2015, SCI REP-UK, V5, DOI 10.1038/srep17423
   Jahani-Sherafat Somayeh, 2018, Gastroenterol Hepatol Bed Bench, V11, P101
   Kang HR, 2016, ONCOL REP, V36, P1119, DOI 10.3892/or.2016.4838
   Koh A, 2016, CELL, V165, P1332, DOI 10.1016/j.cell.2016.05.041
   Li HN, 2020, CANCER MED-US, V9, P9554, DOI 10.1002/cam4.3543
   Lohsiriwat V, 2020, ANN COLOPROCTOL, V36, P78, DOI 10.3393/ac.2020.01.07
   Louis P, 2014, NAT REV MICROBIOL, V12, P661, DOI 10.1038/nrmicro3344
   Mansoori B, 2017, ADV PHARM BULL, V7, P339, DOI 10.15171/apb.2017.041
   Marom R, 2021, AM J HUM GENET, V108, P1710, DOI 10.1016/j.ajhg.2021.08.002
   Namasivayam Vikneswaran, 2017, F1000Res, V6, P199, DOI 10.12688/f1000research.9795.1
   Nittayaboon K, 2022, BIOMED PHARMACOTHER, V151, DOI 10.1016/j.biopha.2022.113214
   Okazaki K, 2000, INT J ONCOL, V17, P39
   Olmo N, 2007, TOXICOL IN VITRO, V21, P254, DOI 10.1016/j.tiv.2006.09.010
   Rawlings JS, 2004, J CELL SCI, V117, P1281, DOI 10.1242/jcs.00963
   Saidak Z, 2018, BIOSCIENCE REP, V38, DOI 10.1042/BSR20171716
   Saus E, 2019, MOL ASPECTS MED, V69, P93, DOI 10.1016/j.mam.2019.05.001
   Schmittgen TD, 2008, NAT PROTOC, V3, P1101, DOI 10.1038/nprot.2008.73
   Sermsri N, 2014, ASIAN PAC J CANCER P, V15, P9015, DOI 10.7314/APJCP.2014.15.20.9015
   Song MY, 2017, CURR COLORECT CANC R, V13, P429, DOI 10.1007/s11888-017-0389-y
   Stabuc B, 2003, ARCH ONCOLOGY, V11, P255, DOI [10.2298/AOO0304255S, DOI 10.2298/AOO0304255S]
   Sun MM, 2017, J GASTROENTEROL, V52, P1, DOI 10.1007/s00535-016-1242-9
   Surangkul D., 2017, P 43TH C SCI TECHNOL, P17
   Tang YL, 2017, BIOMED RES INT-UK, V2017, DOI 10.1155/2017/5905384
   Terao Y, 2001, INT J CANCER, V94, P257, DOI 10.1002/ijc.1448
   Thorn CF, 2011, PHARMACOGENET GENOM, V21, P440, DOI 10.1097/FPC.0b013e32833ffb56
   Wang R, 2019, ONCOL LETT, V18, P5831, DOI 10.3892/ol.2019.10931
   Wang Y, 2018, EXP THER MED, V15, P777, DOI 10.3892/etm.2017.5506
   Wang Y, 2016, ULTRASTRUCT PATHOL, V40, P200, DOI 10.3109/01913123.2016.1170083
   Wong SH, 2019, NAT REV GASTRO HEPAT, V16, P690, DOI 10.1038/s41575-019-0209-8
   Wu XQ, 2018, J CANCER, V9, P2510, DOI 10.7150/jca.25324
   Zhang Jiayao, 2021, Biomed Res Int, V2021, P6648078, DOI 10.1155/2021/6648078
   Zhou Y, 2020, CNS NEUROSCI THER, V26, P309, DOI 10.1111/cns.13254
   Zhu N, 2015, BIOMED REP, V3, P235, DOI 10.3892/br.2015.417
NR 50
TC 2
Z9 2
U1 2
U2 3
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT
JI Biomed Res. Int.
PD JUL 19
PY 2022
VL 2022
AR 6565300
DI 10.1155/2022/6565300
PG 18
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA 3M0YN
UT WOS:000835184900005
PM 35909471
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Chavez-Carbajal, A
   Pizano-Zarate, ML
   Hernandez-Quiroz, F
   Ortiz-Luna, GF
   Morales-Hernandez, RM
   De Sales-Millan, A
   Hernandez-Trejo, M
   Garcia-Vite, A
   Beltran-Lagunes, L
   Hoyo-Vadillo, C
   Garcia-Mena, J
AF Chavez-Carbajal, Alejandra
   Luisa Pizano-Zarate, Maria
   Hernandez-Quiroz, Fernando
   Federico Ortiz-Luna, Guillermo
   Maria Morales-Hernandez, Rosa
   De Sales-Millan, Amapola
   Hernandez-Trejo, Maria
   Garcia-Vite, Angelina
   Beltran-Lagunes, Luis
   Hoyo-Vadillo, Carlos
   Garcia-Mena, Jaime
TI Characterization of the Gut Microbiota of Individuals at Different T2D
   Stages Reveals a Complex Relationship with the Host
SO MICROORGANISMS
LA English
DT Article
DE gut microbiota; type 2 diabetes; prediabetes; metabolic disorders; diet;
   and high-throughput DNA sequencing
ID INTESTINAL MICROBIOTA; METABOLISM; METAGENOME; DYSBIOSIS; GLUCOSE;
   OBESITY
AB In this work, we studied 217 Mexican subjects divided into six groups with different stages of glucose intolerance: 76 Controls (CO), 54 prediabetes (PRE), 14 T2D no medication (T2D-No-M), 14 T2D with Metformin (T2D-M), 22 T2D with polypharmacy (T2D-P), and 37 T2D with polypharmacy and insulin (T2D-P+I). We aimed to determine differences in the gut microbiota diversity for each condition. At the phylum level, we found that Firmicutes and Bacteroidetes outline major changes in the gut microbiota. The gut bacterial richness and diversity of individuals in the T2D-No-M group were lesser than other groups. Interestingly, we found a significant difference in the beta diversity of the gut microbiota among all groups. Higher abundance was found for Comamonadaceae in PRE, and Sutterella spp. in T2D-No-M. In addition, we found associations of specific microbial taxa with clinical parameters. Finally, we report predicted metabolic pathways of gut microbiota linked to T2D-M and PRE conditions. Collectively, these results indicate that each group has specific predicted metabolic characteristics and gut bacteria populations for each phenotype. The results of this study could be used to define strategies to modulate gut microbiota through noninvasive treatments, such as dietary intervention, probiotics or prebiotics, and to improve glucose tolerance of individuals with prediabetes or T2D.
C1 [Chavez-Carbajal, Alejandra; Hernandez-Quiroz, Fernando; De Sales-Millan, Amapola; Garcia-Mena, Jaime] Inst Politecn Nacl, Dept Genet & Biol Mol, Ctr Invest & Estudios Avanzados, Ciudad De Mexico 07360, Mexico.
   [Luisa Pizano-Zarate, Maria; Maria Morales-Hernandez, Rosa] Inst Nacl Perinatol, Dept Nutric & Bioprogramac, Ciudad De Mexico 11000, Mexico.
   [Federico Ortiz-Luna, Guillermo] Inst Nacl Perinatol, Dept Peri & Posmenopausia, Ciudad De Mexico 11000, Mexico.
   [Hernandez-Trejo, Maria] Inst Nacl Perinatol, Dept Neurolobiol Desarrollo, Ciudad De Mexico 1100, Mexico.
   [Garcia-Vite, Angelina] ISSSTE, Clin Med Familiar Gustavo A Madero, Modulo Integral Atenc Paciente Con Diabet Etapas, Ciudad De Mexico 07020, Mexico.
   [Beltran-Lagunes, Luis] ISSSTE, Clin Med Familiar Gustavo A Madero, Jefatura Ensenanza & Invest, Ciudad De Mexico 07020, Mexico.
   [Hoyo-Vadillo, Carlos] Inst Politecn Nacl, Dept Farmacol, Ctr Invest & Estudios Avanzados, Ciudad De Mexico 07360, Mexico.
   [Chavez-Carbajal, Alejandra] McMaster Univ, Hynes Lab, Hlth Sci, HSC 4N45 B-M,1280 Main St West, Hamilton, ON L8S 4K1, Canada.
C3 Instituto Politecnico Nacional - Mexico; Universidad Nacional Autonoma
   de Mexico; Universidad Nacional Autonoma de Mexico; Universidad Nacional
   Autonoma de Mexico; Instituto Politecnico Nacional - Mexico; McMaster
   University
RP Garcia-Mena, J (通讯作者)，Inst Politecn Nacl, Dept Genet & Biol Mol, Ctr Invest & Estudios Avanzados, Ciudad De Mexico 07360, Mexico.; Pizano-Zarate, ML (通讯作者)，Inst Nacl Perinatol, Dept Nutric & Bioprogramac, Ciudad De Mexico 11000, Mexico.
EM alejandra.chavez@cinvestav.mx; pizanozarate@yahoo.com;
   fernando.hernandez@cinvestav.mx; dr.ortiz.luna@gmail.com;
   rmh080868@yahoo.com; dsmn.amapola@gmail.com; maria.h.trejo72@gmail.com;
   angyvite@gmail.com; dr.luisbeltran007@hotmail.com;
   citocromo@cinvestav.mx; jgmena@cinvestav.mx
RI García-Mena, Jaime/B-1625-2008; Hoyo-Vadillo, Carlos/C-2573-2008
OI García-Mena, Jaime/0000-0002-0595-3711; Hoyo-Vadillo,
   Carlos/0000-0002-5161-7508; PIZANO-ZARATE, MARIA
   LUISA/0000-0002-2190-6421; De Sales-Millan, Amapola/0000-0002-2527-8055;
   Chavez-Carbajal, Alejandra/0000-0001-6305-7555
FU "Instituto de Seguridad y Servicios Sociales de los Trabajadores del
   Estado" (ISSSTE); Instituto Nacional de Perinatologia [(539)
   212250-3310-21108-04-1]; Cinvestav [CONACyT-163235 INFR-2011-01]; FONSEC
   [SS/IMSS/ISSSTE-CONACYT-233361]
FX This work was financed by "Instituto de Seguridad y Servicios Sociales
   de los Trabajadores del Estado" (ISSSTE), "Instituto Nacional de
   Perinatologia" (539) 212250-3310-21108-04-1 to M.L.P.Z.; Cinvestav,
   CONACyT-163235 INFR-2011-01, and FONSEC SS/IMSS/ISSSTE-CONACYT-233361 to
   J.G.M.
CR Ainsworth BE, 2011, MED SCI SPORT EXER, V43, P1575, DOI 10.1249/MSS.0b013e31821ece12
   Allin KH, 2018, DIABETOLOGIA, V61, P810, DOI 10.1007/s00125-018-4550-1
   Belizario JE, 2015, FRONT MICROBIOL, V6, DOI [10.1186/1476-069X-6-20, 10.3389/fmicb.2015.01050, 10.3389/fmicb.2015.1050]
   Bo T, 2017, MICROBIOLOGYOPEN, V6, DOI 10.1002/mbo3.491
   Boutagy NE, 2016, BIOCHIMIE, V124, P11, DOI 10.1016/j.biochi.2015.06.020
   Cani PD, 2009, CURR PHARM DESIGN, V15, P1546, DOI 10.2174/138161209788168164
   Carmody RN, 2014, J CLIN INVEST, V124, P4173, DOI 10.1172/JCI72335
   Choi JJ, 2013, ENVIRON HEALTH PERSP, V121, P725, DOI 10.1289/ehp.1306534
   Dedysh SN, 2018, INT J SYST EVOL MICR, V68, P3796, DOI 10.1099/ijsem.0.003062
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Han JL, 2014, WORLD J GASTROENTERO, V20, P17737, DOI 10.3748/wjg.v20.i47.17737
   Hawinkel S, 2019, BRIEF BIOINFORM, V20, P210, DOI 10.1093/bib/bbx104
   Horie M, 2017, EXP ANIM TOKYO, V66, P405, DOI 10.1538/expanim.17-0021
   InBody, 2018, APPL DIAB INBODY NON
   Instituto Nacional de Estadistica y Geografia, 2017, CAUS MORT BAS INT DA
   Jourova L, 2016, BIOMED PAP, V160, P317, DOI 10.5507/bp.2016.039
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Langille MGI, 2013, NAT BIOTECHNOL, V31, P814, DOI 10.1038/nbt.2676
   Lau E, 2015, HORM-INT J ENDOCRINO, V14, P358, DOI 10.14310/horm.2002.1571
   LONG CL, 1967, METABOLISM, V16, P413, DOI 10.1016/0026-0495(67)90132-1
   McMurdie PJ, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0061217
   Methe BA, 2012, NATURE, V486, P215, DOI 10.1038/nature11209
   Morgan XC, 2012, GENOME BIOL, V13, DOI 10.1186/gb-2012-13-9-r79
   Murtaza N, 2019, NUTRIENTS, V11, DOI 10.3390/nu11020261
   Murugesan S, 2015, EUR J CLIN MICROBIOL, V34, P1337, DOI 10.1007/s10096-015-2355-4
   Parks DH, 2014, BIOINFORMATICS, V30, P3123, DOI 10.1093/bioinformatics/btu494
   Perez-Lizaur A.B, 2014, SISTEMA MEXICANO ALI, V4th ed.
   Petroni ML, 2003, ACTA DIABETOL, V40, pS59, DOI 10.1007/s00592-003-0028-8
   Pussinen PJ, 2011, DIABETES CARE, V34, P392, DOI 10.2337/dc10-1676
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Rajilic-Stojanovic M, 2007, ENVIRON MICROBIOL, V9, P2125, DOI 10.1111/j.1462-2920.2007.01369.x
   Rodriguez J, 2018, CURR OPIN CLIN NUTR, V21, P294, DOI 10.1097/MCO.0000000000000468
   Ross MC, 2015, MICROBIOME, V3, DOI 10.1186/s40168-015-0072-y
   Sato J, 2014, DIABETES CARE, V37, P2343, DOI 10.2337/dc13-2817
   Segata N, 2011, GENOME BIOL, V12, DOI 10.1186/gb-2011-12-6-r60
   Sepp E, 2014, MICROB ECOL HEALTH D, V25, DOI 10.3402/mehd.v25.22857
   Shin NR, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.02271
   Stinson LF, 2019, FRONT MICROBIOL, V10, DOI 10.3389/fmicb.2019.01124
   Thorsen J, 2016, MICROBIOME, V4, DOI 10.1186/s40168-016-0208-8
   Wang Y, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0172774
   WHO, 2018, GLOB PHYS ACT SURV
   World Health Organization, 2016, GLOBAL REPORT DIABET
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Wu TZ, 2017, DIABETES OBES METAB, V19, P290, DOI 10.1111/dom.12812
   Wu XK, 2010, CURR MICROBIOL, V61, P69, DOI 10.1007/s00284-010-9582-9
NR 45
TC 32
Z9 34
U1 3
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-2607
J9 MICROORGANISMS
JI Microorganisms
PD JAN
PY 2020
VL 8
IS 1
AR 94
DI 10.3390/microorganisms8010094
PG 16
WC Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology
GA KN2DE
UT WOS:000514650700058
PM 31936722
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Halmos, T
   Suba, I
AF Halmos, Tamas
   Suba, Ilona
TI Role of endocrinological factors and metabolic processes in regulating
   life-span
SO ORVOSI HETILAP
LA English
DT Article
DE insulin resistance; insulin-like growth factors; mitohormesis; mTOR;
   metformin; calorie restriction
ID DEVELOPMENTAL ORIGINS; INSULIN SENSITIVITY; GROWTH; MITOHORMESIS;
   METFORMIN; LONGEVITY; HEALTH; MTOR; AXIS
AB People want to live as long as possible in good health. If we eliminate the unfavorable external conditions, the life expectancy could exceed 100 years. In the 20th and 21th centuries, life expectancy in welfare societies increased significantly, including in Hungary. Based on the reviewed literature, we examined what endocrinological and metabolic factors play a role in prolonging life in addition to genetics and inheritance. We examined all endogenous factors that can positively or negatively affect age-related diseases (Alzheimer's disease, cardiovascular disease, cancer) and longevity. We highlighted the aging effects of hyperinsulinemia, insulin resistance, metabolic syndrome, the controversial role of insulin-like growth factor-1, and more recently discovered peptides involved in prolonging lifespan, such as klotho and humanin. We described the role of mitochondria in determining longevity, we demonstrated the process of mitohormesis and its stress-protective function. We presented the target organ of rapamycin, mTOR, the inhibition of which prolongs lifespan, as well as sirtuins. We covered the process of autophagy and described the role of senolytics in aging. The decrease in autoimmunity in old age contributes to the shortening of life expectancy, we referred to the coordinating role of the thymus. We highlighted the important role of intestinal microbiome in the regulation of longevity. We referred to human data obtained from observations on "centenarians". We examined what intervention options are available to prolong healthy life expectancy. Among the lifestyle options, we highlighted the beneficial role of calorie reduction and exercise. We examined the putative beneficial effects of some drugs. These include metformin, acarbose, resveratrol. The effect of each of these drugs is similar to calorie restriction. There is no "miracle cure" that has been shown to prolong life-span in humans. Some genes and gene mutations have beneficial effects, but this can be modified by environmental factors, diseases, accidents, and other external harms. We highlight the accelerating effects of obesity, low-grade inflammation, and insulin resistance on aging. Due to the prevalence of metabolic syndrome, this poses a significant risk to public health. The assessment of the effects of insulin, growth hormone, and insulin-like growth factors remains controversial. A healthy, mentally and physically active lifestyle, calorie reduction is definitely beneficial. The evaluation of life-prolonging agents is still controversial.
C1 [Halmos, Tamas] Metabolikus Ambulancia, MAZSIHISZ Szeretetkorhaz, Budapest, Hungary.
   [Suba, Ilona] Tudogondozo Int, Bajcsy Zsilinszky Korhaz Rendeloint, Budapest, Hungary.
RP Halmos, T (通讯作者)，Kikelet U 43-b, H-1125 Budapest, Hungary.
EM fishwash@t-online.hu; suba.ilona@gmail.com
CR Adams J.U., 2008, NAT ED, V1, P130
   Aguirre GA, 2016, J TRANSL MED, V14, DOI 10.1186/s12967-015-0762-z
   Akintola AA, 2015, FRONT ENDOCRINOL, V6, DOI 10.3389/fendo.2015.00013
   AsghariHanjani Nazanin, 2019, Med J Islam Repub Iran, V33, P56, DOI 10.34171/mjiri.33.56
   Ashpole NM, 2017, GEROSCIENCE, V39, P129, DOI 10.1007/s11357-017-9971-0
   Barcena C, 2018, INT REV CEL MOL BIO, V340, P35, DOI 10.1016/bs.ircmb.2018.05.002
   Bareja A, 2019, FRONT CELL DEV BIOL, V7, DOI 10.3389/fcell.2019.00183
   Barzilai N, 2016, CELL METAB, V23, P1060, DOI 10.1016/j.cmet.2016.05.011
   Bonomini F, 2015, AGING DIS, V6, P109, DOI 10.14336/AD.2014.0305
   Broskey NT, 2019, EXERC SPORT SCI REV, V47, P169, DOI 10.1249/JES.0000000000000193
   Cheikhi A, 2019, J GERONTOL A-BIOL, V74, P1031, DOI 10.1093/gerona/glz061
   Chistiakov DA, 2014, BIOMED RES INT, V2014, DOI 10.1155/2014/238463
   Zarate SC, 2019, FRONT AGING NEUROSCI, V11, DOI 10.3389/fnagi.2019.00123
   Csaba G, 2019, ACTA MICROBIOL IMM H, V66, P1, DOI 10.1556/030.65.2018.029
   Csaba G, 2018, ORVOSI HETILAP, V159, P1655, DOI 10.1556/650.2018.31140
   Csaba G, 2016, ACTA MICROBIOL IMM H, V63, P139, DOI 10.1556/030.63.2016.2.1
   De Haes W, 2014, P NATL ACAD SCI USA, V111, pE2501, DOI 10.1073/pnas.1321776111
   Dorling JL, 2020, AGEING RES REV, V64, DOI 10.1016/j.arr.2020.101038
   Espada L., 2019, BIORXIV863357, DOI 10.1101/863357.
   Fernandez E, 2019, PATHOBIOL AGING AGE, V9, DOI 10.1080/20010001.2019.1657756
   Gonzalez-Freire M, 2020, AGEING RES REV, V59, DOI 10.1016/j.arr.2020.101037
   Halmos T, 2019, ORVOSI HETILAP, V160, P1774, DOI 10.1556/650.2019.31507
   Halmos T, 2016, ORVOSI HETILAP, V157, P13, DOI 10.1556/650.2015.30296
   Harrison DE, 2014, AGING CELL, V13, P273, DOI 10.1111/acel.12170
   Jaba T., 2019, J BIOMED SCI, V8, P3
   Kim Minhoo, 2020, Transl Med Aging, V4, P103
   Kirkland JL, 2020, J INTERN MED, V288, P518, DOI 10.1111/joim.13141
   Kolb H, 2012, NAT REV ENDOCRINOL, V8, P183, DOI 10.1038/nrendo.2011.158
   Konopka AR, 2019, AGING CELL, V18, DOI 10.1111/acel.12880
   Kulkarni AS, 2020, CELL METAB, V32, P15, DOI 10.1016/j.cmet.2020.04.001
   Mao K, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-018-04805-5
   Marron MM, 2019, METABOLISM, V94, P28, DOI 10.1016/j.metabol.2019.01.010
   Milman S, 2016, CELL METAB, V23, P980, DOI 10.1016/j.cmet.2016.05.014
   Milman S, 2014, AGING CELL, V13, P769, DOI 10.1111/acel.12213
   NEEL JV, 1962, AM J HUM GENET, V14, P353
   Nguyen V, 2017, J IMMUNOL RES, V2017, DOI 10.1155/2017/4807853
   Olejnik A, 2018, BIOMED RES INT, V2018, DOI 10.1155/2018/5171945
   Papadopoli David, 2019, F1000Res, V8, DOI 10.12688/f1000research.17196.1
   Pifferi F, 2018, COMMUN BIOL, V1, DOI 10.1038/s42003-018-0024-8
   Podlutsky A, 2017, GEROSCIENCE, V39, P147, DOI 10.1007/s11357-017-9966-x
   Pollack RM, 2017, J GERONTOL A-BIOL, V72, P1703, DOI 10.1093/gerona/glx041
   Preston JD, 2018, GERONTOLOGY, V64, P237, DOI 10.1159/000485506
   Rinninella E, 2020, MICROORGANISMS, V8, DOI 10.3390/microorganisms8081140
   Ristow M, 2014, DOSE-RESPONSE, V12, P288, DOI 10.2203/dose-response.13-035.Ristow
   Sadagurski M, 2013, ENDOCRIN METAB CLIN, V42, P127, DOI 10.1016/j.ecl.2012.11.008
   Saxton RA, 2017, CELL, V168, P960, DOI [10.1016/j.cell.2017.02.004, 10.1016/j.cell.2017.03.035]
   Sebastiani P, 2017, J GERONTOL A-BIOL, V72, P1453, DOI 10.1093/gerona/glx027
   Singh PP, 2019, CELL, V177, P200, DOI 10.1016/j.cell.2019.02.038
   Soukas AA, 2019, TRENDS ENDOCRIN MET, V30, P745, DOI 10.1016/j.tem.2019.07.015
   Suh Y, 2008, P NATL ACAD SCI USA, V105, P3438, DOI 10.1073/pnas.0705467105
   Sunjaya AP, 2021, DIABETES METAB, V47, DOI 10.1016/j.diabet.2020.09.009
   Szekacs B, 2016, DEMOGRAFIA, V59, P155
   Szekacs B, 2005, GERIATRICS MED OLD A
   Tachang GK, 2016, J DIABETES METAB, V7, DOI 10.4172/2155-6156.1000674
   Templeman NM, 2017, CELL REP, V20, P451, DOI 10.1016/j.celrep.2017.06.048
   Vitale G, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00027
   Weichhart T, 2018, GERONTOLOGY, V64, P127, DOI 10.1159/000484629
   Xiao J, 2016, GROWTH HORM IGF RES, V29, P21, DOI 10.1016/j.ghir.2016.03.005
   Xu M, 2018, NAT MED, V24, P1246, DOI 10.1038/s41591-018-0092-9
   Yen K, 2020, AGING-US, V12, P11185, DOI 10.18632/aging.103534
   Yen K, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-32616-7
   Yu DY, 2019, CELL REP, V29, P236, DOI 10.1016/j.celrep.2019.08.084
   Yun J, 2014, CELL METAB, V19, P757, DOI 10.1016/j.cmet.2014.01.011
   Zhou XX, 2017, J HEMATOL ONCOL, V10, DOI 10.1186/s13045-017-0391-5
NR 64
TC 0
Z9 0
U1 0
U2 8
PU AKADEMIAI KIADO ZRT
PI BUDAPEST
PA BUDAFOKI UT 187-189-A-3, H-1117 BUDAPEST, HUNGARY
SN 0030-6002
EI 1788-6120
J9 ORVOSI HETILAP
JI Orvosi Hetilap
PD AUG
PY 2021
VL 162
IS 33
BP 1318
EP 1327
DI 10.1556/650.2021.32200
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA UB8XN
UT WOS:000686122200002
PM 34392236
OA Green Accepted
DA 2023-06-08
ER

PT J
AU Shi, ZJ
   Chen, G
   Cao, Z
   Wu, F
   Lei, HH
   Chen, C
   Song, YC
   Liu, CX
   Li, JQ
   Zhou, JL
   Lu, YJ
   Zhang, LM
AF Shi, Zunji
   Chen, Gui
   Cao, Zheng
   Wu, Fang
   Lei, Hehua
   Chen, Chuan
   Song, Yuchen
   Liu, Caixiang
   Li, Jinquan
   Zhou, Jinlin
   Lu, Yujing
   Zhang, Limin
TI Gut Microbiota and Its Metabolite Deoxycholic Acid Contribute to
   Sucralose Consumption-Induced Nonalcoholic Fatty Liver Disease
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Article
DE deoxycholic acid; bile acids; gut microbiota; sucralose; farnesol X
   receptor
ID NUCLEAR RECEPTOR FXR; FARNESOID X-RECEPTOR; BILE-ACID;
   INSULIN-RESISTANCE; LIPID-METABOLISM; INFLAMMATION; ACTIVATION;
   SWEETENERS; GLUCOSE; OBESE
AB As important signal metabolites within enterohepatic circulation, bile acids (BAs) play a pivotal role during the occurrence and development of diet-induced nonalcoholic fatty liver disease (NAFLD). Here, we evaluated the functional effects of BAs and gut microbiota contributing to sucralose consumption-induced NAFLD of mice. The results showed that sucralose consumption significantly upregulated the abundance of intestinal genera Bacteroides and Clostridium, which produced deoxycholic acid (DCA) accumulating in multiple biological matrixes including feces, serum, and liver of mice. Subsequently, elevated hepatic DCA, one of the endogenous antagonists of the farnesol X receptor (Fxr), inhibited hepatic gene expression including a small heterodimer partner (Shp) and Fxr leading to sucralose-induced NAFLD in mice. Dietary supplements with fructo-oligosaccharide or metformin markedly restored genera Bacteroides and Clostridium abundance and the DCA level of sucralose-consuming mice, which eventually ameliorated NAFLD. These findings highlighted the effects of gut microbiota and its metabolite DCA on sucralose-induced NAFLD of mice.
C1 [Shi, Zunji; Chen, Gui; Cao, Zheng; Wu, Fang; Lei, Hehua; Chen, Chuan; Song, Yuchen; Liu, Caixiang; Zhang, Limin] Chinese Acad Sci, Innovat Acad Precis Measurement Sci & Technol, State Key Lab Magnet Resonance & Atom & Mol Phys, Natl Ctr Magnet Resonance Wuhan,Key Lab Magnet Re, Wuhan 430071, Peoples R China.
   [Chen, Gui; Cao, Zheng; Wu, Fang; Chen, Chuan; Song, Yuchen] Univ Chinese Acad Sci, Beijing 100049, Peoples R China.
   [Li, Jinquan] Huazhong Agr Univ, Coll Food Sci & Technol, Key Lab Environm Correlat Dietol, Wuhan 430070, Peoples R China.
   [Zhou, Jinlin; Lu, Yujing; Zhang, Limin] Engn Res Acad High Value Utilizat Green Plants, Meizhou 514021, Peoples R China.
   [Lu, Yujing] Guangdong Univ Technol, Sch Biomed & Pharmaceut Sci, Guangzhou 510006, Peoples R China.
   [Zhang, Limin] Huazhong Univ Sci & Technol, Wuhan Natl Lab Optoelect, Wuhan 430074, Peoples R China.
C3 Chinese Academy of Sciences; Chinese Academy of Sciences; University of
   Chinese Academy of Sciences, CAS; Huazhong Agricultural University;
   Guangdong University of Technology; Huazhong University of Science &
   Technology
RP Zhang, LM (通讯作者)，Chinese Acad Sci, Innovat Acad Precis Measurement Sci & Technol, State Key Lab Magnet Resonance & Atom & Mol Phys, Natl Ctr Magnet Resonance Wuhan,Key Lab Magnet Re, Wuhan 430071, Peoples R China.; Zhang, LM (通讯作者)，Engn Res Acad High Value Utilizat Green Plants, Meizhou 514021, Peoples R China.; Zhang, LM (通讯作者)，Huazhong Univ Sci & Technol, Wuhan Natl Lab Optoelect, Wuhan 430074, Peoples R China.
EM zhanglm@wipm.ac.cn
OI Shi, Zunji/0000-0002-1276-6762
FU National Key Research and Development Project [2018YFE0110800]; National
   Natural Science Foundation of China [21635006]; China Postdoctoral
   Science Foundation [2019M662893]; Foshan Core Technology Tackling Key
   Project [1920001000262]
FX This study was financially supported by the National Key Research and
   Development Project (2018YFE0110800), National Natural Science
   Foundation of China (21635006), China Postdoctoral Science Foundation
   (2019M662893), and Foshan Core Technology Tackling Key Project
   (1920001000262).
CR Arab JP, 2017, HEPATOLOGY, V65, P350, DOI 10.1002/hep.28709
   Bian XM, 2017, FOOD CHEM TOXICOL, V107, P530, DOI 10.1016/j.fct.2017.04.045
   Bian XM, 2017, FRONT PHYSIOL, V8, DOI 10.3389/fphys.2017.00487
   Bornemann V, 2018, J TOXICOL ENV HEAL A, V81, P913, DOI 10.1080/15287394.2018.1502560
   Brufau G, 2010, HEPATOLOGY, V52, P1455, DOI 10.1002/hep.23831
   Cariou B, 2011, NUTR METAB, V8, DOI 10.1186/1743-7075-8-48
   Chavez-Talavera O, 2017, GASTROENTEROLOGY, V152, P1679, DOI 10.1053/j.gastro.2017.01.055
   Day EA, 2017, TRENDS ENDOCRIN MET, V28, P545, DOI 10.1016/j.tem.2017.05.004
   Eisenreich A, 2020, FOOD CHEM, V321, DOI 10.1016/j.foodchem.2020.126700
   Everard A, 2011, DIABETES, V60, P2775, DOI 10.2337/db11-0227
   Ezzaidi N, 2019, CANCER LETT, V459, P186, DOI 10.1016/j.canlet.2019.114425
   Ferslew BC, 2015, DIGEST DIS SCI, V60, P3318, DOI 10.1007/s10620-015-3776-8
   Fitch C, 2012, J ACAD NUTR DIET, V112, P739, DOI 10.1016/j.jand.2012.03.009
   Gardner C, 2012, DIABETES CARE, V35, P1798, DOI 10.2337/dc12-9002
   Haeusler RA, 2013, DIABETES, V62, P4184, DOI 10.2337/db13-0639
   Ruiz-Ojeda FJ, 2019, ADV NUTR, V10, pS31, DOI 10.1093/advances/nmy037
   Jiao N, 2018, GUT, V67, P1881, DOI 10.1136/gutjnl-2017-314307
   Lambert G, 2003, J BIOL CHEM, V278, P2563, DOI 10.1074/jbc.M209525200
   Langer S, 2016, J NEPHROL, V29, P765, DOI 10.1007/s40620-015-0258-1
   Li DM, 2019, J AGR FOOD CHEM, V67, P12208, DOI 10.1021/acs.jafc.9b05495
   Li XZ, 2017, MOLECULES, V22, DOI 10.3390/molecules22050699
   Lin H, 2019, J AGR FOOD CHEM, V67, P3624, DOI 10.1021/acs.jafc.9b00249
   Liu CW, 2019, J PROTEOMICS, V196, P1, DOI 10.1016/j.jprot.2019.01.011
   Ma YJ, 2013, PHARM RES-DORDR, V30, P1447, DOI 10.1007/s11095-013-0986-7
   McMahan RH, 2013, J BIOL CHEM, V288, P11761, DOI 10.1074/jbc.M112.446575
   Min HK, 2012, CELL METAB, V15, P665, DOI 10.1016/j.cmet.2012.04.004
   Mouzaki M, 2013, HEPATOLOGY, V58, P120, DOI 10.1002/hep.26319
   Pierre JF, 2016, AM J PHYSIOL-GASTR L, V311, pG286, DOI 10.1152/ajpgi.00202.2016
   Qin N, 2014, NATURE, V513, P59, DOI 10.1038/nature13568
   Ridlon JM, 2006, J LIPID RES, V47, P241, DOI 10.1194/jlr.R500013-JLR200
   Rivero-Gutierrez B, 2017, MOL NUTR FOOD RES, V61, DOI 10.1002/mnfr.201600622
   Roberts A, 2000, FOOD CHEM TOXICOL, V38, pS31, DOI 10.1016/S0278-6915(00)00026-0
   Sayin SI, 2013, CELL METAB, V17, P225, DOI 10.1016/j.cmet.2013.01.003
   Schaap FG, 2014, NAT REV GASTRO HEPAT, V11, P55, DOI 10.1038/nrgastro.2013.151
   Schiffman SS, 2019, FOOD CHEM TOXICOL, V132, DOI 10.1016/j.fct.2019.110692
   Shin NR, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.02271
   Smith BK, 2016, AM J PHYSIOL-ENDOC M, V311, pE730, DOI 10.1152/ajpendo.00225.2016
   STELLWAG EJ, 1979, J LIPID RES, V20, P325
   Suez J, 2014, NATURE, V514, P181, DOI 10.1038/nature13793
   Sylvetsky AC, 2012, AM J CLIN NUTR, V96, P640, DOI 10.3945/ajcn.112.034751
   Taylor SA, 2018, HEPATOLOGY, V68, P1229, DOI 10.1002/hep.30078
   Vallim TQD, 2013, CELL METAB, V17, P657, DOI 10.1016/j.cmet.2013.03.013
   Vanni E, 2009, HEPATOLOGY, V49, P1790, DOI 10.1002/hep.23036
   Wahlstrom A, 2016, CELL METAB, V24, P41, DOI 10.1016/j.cmet.2016.05.005
   Watanabe M, 2004, J CLIN INVEST, V113, P1408, DOI 10.1172/JCI200421025
   Yang ZX, 2010, HEPATOL INT, V4, P741, DOI 10.1007/s12072-010-9202-6
   Yerevanian A, 2019, CURR OBES REP, V8, P156, DOI 10.1007/s13679-019-00335-3
   Yoshimoto S, 2013, NATURE, V499, P97, DOI 10.1038/nature12347
   Yu JH, 2002, J BIOL CHEM, V277, P31441, DOI 10.1074/jbc.M200474200
   Zhang YQ, 2006, P NATL ACAD SCI USA, V103, P1006, DOI 10.1073/pnas.0506982103
   Zheng XJ, 2017, BMC BIOL, V15, DOI 10.1186/s12915-017-0462-7
   Zhou KQ, 2017, J FUNCT FOODS, V33, P194, DOI 10.1016/j.jff.2017.03.045
NR 52
TC 11
Z9 11
U1 6
U2 59
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
EI 1520-5118
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD APR 7
PY 2021
VL 69
IS 13
BP 3982
EP 3991
DI 10.1021/acs.jafc.0c07467
EA MAR 2021
PG 10
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA RL5MV
UT WOS:000639018000019
PM 33755449
DA 2023-06-08
ER

PT J
AU Chen, LC
   Fan, ZY
   Wang, HY
   Wen, DC
   Zhang, SY
AF Chen, Li-Chun
   Fan, Zhong-Yang
   Wang, Hong-Yu
   Wen, Dong-Cheng
   Zhang, Shi-Yu
TI Effect of polysaccharides from adlay seed on anti-diabetic and gut
   microbiota
SO FOOD & FUNCTION
LA English
DT Article
ID TYPE-2 DIABETES-MELLITUS; PANCREATIC BETA-CELLS; ALZHEIMERS-DISEASE;
   HEALTH; INSULIN; IMPACT; DIET; METAGENOME; OBESITY; RATS
AB Diabetes is a chronic metabolic disease characterized by elevated blood glucose levels due to insulin resistance and beta-cell dysfunction. This study aims to examine the effects of polysaccharides from adlay seeds (PAS) on hyperglycemia and gut microbiota in streptozocin (STZ)-induced diabetic mice. The administration of PAS in diabetic mice caused a significant decrease in the glucose level and serum levels of glycosylated hemoglobin (HbA1c). Similarly, PAS also showed decreased total cholesterol (TC) and triglyceride (TG) concentrations. Furthermore, a significant increase in the concentrations of glucagon-like peptide 1 (GLP-1) was observed. Unexpectedly, PAS reduced the concentrations of anti-amyloid beta (A beta(1-42)) protein. Also, histopathological examination showed that PAS contributed to the reduction of STZ-lesioned pancreatic cells. Metformin treatment significantly reduced the diversity of the gut microbiota, while PAS treatment altered the diversity and composition of the microbiota. Collectively, our findings demonstrate that the hypoglycemic effects of PAS in type-2 diabetic mice (T2D) may be associated with the regulation of the intestinal microbiota and its metabolic pathways.
C1 [Chen, Li-Chun] Zhejiang Gongshang Univ, Coll Food & Biol Engn, Hangzhou 310035, Zhejiang, Peoples R China.
   [Fan, Zhong-Yang; Wang, Hong-Yu; Wen, Dong-Cheng; Zhang, Shi-Yu] Zhejiang Univ Sci & Technol, Zhejiang Prov Key Lab Chem & Bio Proc Technol Agr, Hangzhou 310023, Zhejiang, Peoples R China.
C3 Zhejiang Gongshang University; Zhejiang University of Science &
   Technology
RP Chen, LC (通讯作者)，Zhejiang Gongshang Univ, Coll Food & Biol Engn, Hangzhou 310035, Zhejiang, Peoples R China.
EM clc8127@163.com
OI lichun, chen/0000-0002-9465-5256
FU National Natural Science Foundation of China (NSFC) [31741101]; Zhejiang
   Science Technology Project [2018C02054]; Public Projects of Zhejiang
   Province [LGN19C200014]
FX This work was partly supported by the National Natural Science
   Foundation of China (NSFC, 31741101), the Zhejiang Science Technology
   Project (No. 2018C02054), and the Public Projects of Zhejiang Province
   (No. LGN19C200014).
CR Bruehl H, 2007, J CLIN ENDOCR METAB, V92, P2439, DOI 10.1210/jc.2006-2540
   Chen C, 2018, FOOD FUNCT, V9, P3732, DOI [10.1039/C7FO01346A, 10.1039/c7fo01346a]
   Clemente JC, 2012, CELL, V148, P1258, DOI 10.1016/j.cell.2012.01.035
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Gao H, 2018, CARBOHYD POLYM, V201, P624, DOI 10.1016/j.carbpol.2018.08.075
   Gilon P, 2014, CELL CALCIUM, V56, P340, DOI 10.1016/j.ceca.2014.09.001
   Hehemann JH, 2010, NATURE, V464, P908, DOI 10.1038/nature08937
   Human Microbiome Project Consortium, 2012, Nature, V486, P207, DOI 10.1038/nature11234
   Joshi SR, 2015, EXPERT OPIN PHARMACO, V16, P597, DOI 10.1517/14656566.2015.1009894
   Jovel J, 2016, FRONT MICROBIOL, V7, DOI 10.3389/fmicb.2016.00459
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kim MJ, 2008, CARBOHYD POLYM, V74, P787, DOI 10.1016/j.carbpol.2008.04.043
   Liu YT, 2013, FOOD CHEM TOXICOL, V62, P285, DOI 10.1016/j.fct.2013.08.082
   Makki K, 2018, CELL HOST MICROBE, V23, P705, DOI 10.1016/j.chom.2018.05.012
   Maslowski KM, 2011, NAT IMMUNOL, V12, P5, DOI 10.1038/ni0111-5
   Memarrast F, 2017, DIABETES-METAB RES, V33, DOI 10.1002/dmrr.2912
   Nie QX, 2019, FOOD HYDROCOLLOID, V86, P34, DOI 10.1016/j.foodhyd.2017.12.026
   Oh DY, 2016, NAT REV DRUG DISCOV, V15, P161, DOI 10.1038/nrd.2015.4
   Pagliuca FW, 2014, CELL, V159, P428, DOI 10.1016/j.cell.2014.09.040
   Patterson E, 2015, MICROBIOL-SGM, V161, P182, DOI 10.1099/mic.0.082610-0
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Raccah D, 2017, DIABETES METAB, V43, P110, DOI 10.1016/j.diabet.2016.11.007
   Ravussin Y, 2012, OBESITY, V20, P738, DOI 10.1038/oby.2011.111
   Sapkota S., 2015, PLOS ONE, V10, P118
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Snima KS, 2012, CARBOHYD POLYM, V89, P1003, DOI 10.1016/j.carbpol.2012.04.050
   Sonnenburg ED, 2016, NATURE, V529, P212, DOI 10.1038/nature16504
   Thomsen SK, 2018, NAT GENET, V50, P1122, DOI 10.1038/s41588-018-0173-1
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Turnbaugh PJ, 2009, NATURE, V457, P480, DOI 10.1038/nature07540
   Walker JM, 2015, NUTRIENTS, V7, P7332, DOI 10.3390/nu7095341
   Wang CY, 2010, FOOD RES INT, V43, P819, DOI 10.1016/j.foodres.2009.11.020
   Wang KP, 2018, J FUNCT FOODS, V40, P261, DOI 10.1016/j.jff.2017.11.004
   Wang L, 2013, INT J BIOL MACROMOL, V61, P317, DOI 10.1016/j.ijbiomac.2013.07.028
   Wang MY, 2015, P NATL ACAD SCI USA, V112, P2503, DOI 10.1073/pnas.1424934112
   Wang XF, 2017, J NEUROL SCI, V380, P262, DOI 10.1016/j.jns.2017.07.044
   Wang Y, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0172774
   Wang ZY, 2014, CELL METAB, V19, P872, DOI 10.1016/j.cmet.2014.03.010
   Wauson EM, 2012, MOL CELL, V47, P851, DOI 10.1016/j.molcel.2012.08.001
   Wu JJ, 2016, CARBOHYD POLYM, V144, P474, DOI 10.1016/j.carbpol.2016.02.040
   Xiao H, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-02565-8
   Xu L, 2017, FOOD CHEM, V229, P312, DOI 10.1016/j.foodchem.2017.02.096
   Xu W, 2015, INT J BIOL MACROMOL, V72, P575, DOI 10.1016/j.ijbiomac.2014.09.011
   Yao Y, 2015, INT J BIOL MACROMOL, V80, P246, DOI 10.1016/j.ijbiomac.2015.06.033
   Yore MM, 2014, CELL, V159, P318, DOI 10.1016/j.cell.2014.09.035
   Zhang XY, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0071108
   Zhang XQ, 2015, SCI REP-UK, V5, DOI 10.1038/srep10737
   Zhernakova A, 2016, SCIENCE, V352, P565, DOI 10.1126/science.aad3369
   Zhu F, 2017, TRENDS FOOD SCI TECH, V61, P160, DOI 10.1016/j.tifs.2016.12.003
   Zhu KX, 2016, J AGR FOOD CHEM, V64, P1938, DOI 10.1021/acs.jafc.5b06103
NR 50
TC 32
Z9 33
U1 2
U2 98
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD JUL 1
PY 2019
VL 10
IS 7
BP 4372
EP 4380
DI 10.1039/c9fo00406h
PG 9
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA IK6GK
UT WOS:000476683600048
PM 31276140
DA 2023-06-08
ER

PT J
AU Yang, HJ
   Zhang, T
   Wu, XG
   Kim, MJ
   Kim, YH
   Yang, ES
   Yoon, YS
   Park, S
AF Yang, Hye-Jeong
   Zhang, Ting
   Wu, Xuan-Gao
   Kim, Min-Jung
   Kim, Young-Ho
   Yang, Eun-Suk
   Yoon, Yeong-Seok
   Park, Sunmin
TI Aqueous Blackcurrant Extract Improves Insulin Sensitivity and Secretion
   and Modulates the Gut Microbiome in Non-Obese Type 2 Diabetic Rats
SO ANTIOXIDANTS
LA English
DT Article
DE blackcurrants; insulin sensitivity; insulin secretion; inflammation;
   &#946; -cell mass; gut microbiota
ID GLUCAGON-LIKE PEPTIDE-1; BETA-CELL PROLIFERATION; HIGH-FAT DIET;
   METABOLIC SYNDROME; BLOOD-GLUCOSE; RIBES-NIGRUM; ANTHOCYANINS; MELLITUS;
   MASS; PANCREATECTOMY
AB This study was undertaken to determine whether aqueous blackcurrant extracts (BC) improve glucose metabolism and gut microbiomes in non-obese type 2 diabetic animals fed a high-fat diet and to identify the mechanism involved. Partially pancreatectomized male Sprague-Dawley rats were provided a high-fat diet containing 0% (control), 0.2% (L-BC; low dosage), 0.6% (M-BC; medium dosage), and 1.8% (H-BC; high dosage) blackcurrant extracts; 0.2% metformin (positive-C); plus 1.8%, 1.6%, 1.2%, 0%, and 1.6% dextrin, specifically indigestible dextrin, daily for 8 weeks. Daily blackcurrant extract intakes were equivalent to 100, 300, and 900 mg/kg body weight (bw). After a 2 g glucose or maltose/kg bw challenge, serum glucose and insulin concentrations during peak and final states were obviously lower in the M-BC and H-BC groups than in the control group (p < 0.05). Intraperitoneal insulin tolerance testing showed that M-BC and H-BC improved insulin resistance. Hepatic triglyceride deposition, TNF-alpha expression, and malondialdehyde contents were lower in the M-BC and H-BC groups than in the control group. Improvements in insulin resistance in the M-BC and H-BC groups were associated with reduced inflammation and oxidative stress (p < 0.05). Hyperglycemic clamp testing showed that insulin secretion capacity increased in the acute phase (2 to 10 min) in the M-BC and H-BC groups and that insulin sensitivity in the hyperglycemic state was greater in these groups than in the control group (p < 0.05). Pancreatic beta-cell mass was greater in the M-BC, H-BC, and positive-C groups than in the control group. Furthermore, beta-cell proliferation appeared to be elevated and apoptosis was suppressed in these three groups (p < 0.05). Serum propionate and butyrate concentrations were higher in the M-BC and H-BC groups than in the control group. BC dose-dependently increased alpha-diversity of the gut microbiota and predicted the enhancement of oxidative phosphorylation-related microbiome genes and downregulation of carbohydrate digestion and absorption-related genes, as determined by PICRUSt2 analysis. In conclusion, BC enhanced insulin sensitivity and glucose-stimulated insulin secretion, which improved glucose homeostasis, and these improvements were associated with an incremental increase of the alpha-diversity of gut microbiota and suppressed inflammation and oxidative stress.
C1 [Yang, Hye-Jeong; Kim, Min-Jung] Korean Food Res Inst, Res Div Food Funct, Wanjoo 55365, South Korea.
   [Zhang, Ting; Wu, Xuan-Gao; Park, Sunmin] Hoseo Univ, Dept Bioconvergence Syst, Asan 31499, South Korea.
   [Kim, Young-Ho; Yoon, Yeong-Seok] Hanter Co Ltd, Jeongeup 56204, South Korea.
   [Yang, Eun-Suk] Jiwon Co Ltd, Jeongeup 56212, South Korea.
   [Park, Sunmin] Hoseo Univ, Dept Food & Nutr, Obes Diabet Res Ctr, Asan 31499, South Korea.
C3 Korea Food Research Institute (KFRI); Hoseo University; Hoseo University
RP Park, S (通讯作者)，Hoseo Univ, Dept Bioconvergence Syst, Asan 31499, South Korea.; Park, S (通讯作者)，Hoseo Univ, Dept Food & Nutr, Obes Diabet Res Ctr, Asan 31499, South Korea.
EM yhj@kfri.re.kr; zhangting92925@gmail.com; niyani0@naver.com;
   kmj@kfri.re.kr; kimyh@tiumter.com; yanges@tiumter.com;
   yoonys@tiumter.com; smpark@hoseo.edu
RI Park, Sun/GSD-9620-2022; WU, XUAN/ISS-8430-2023
OI Park, Sunmin/0000-0002-6092-8340; Yoon, Yeong-Seok/0000-0002-7103-6460
FU "Food Functionality Evaluation program" under the Ministry of
   Agriculture, Food and Rural Affairs; Korea Food Research Institute
FX This work was supported by "Food Functionality Evaluation program" under
   the Ministry of Agriculture, Food and Rural Affairs and partly Korea
   Food Research Institute.
CR Adisakwattana S, 2011, J CLIN BIOCHEM NUTR, V49, P36, DOI 10.3164/jcbn.10-116
   Campbell MD, 2020, NAT REV ENDOCRINOL, V16, P395, DOI 10.1038/s41574-019-0316-1
   Castro-Acosta ML, 2016, J NUTR BIOCHEM, V38, P154, DOI 10.1016/j.jnutbio.2016.09.002
   Chen XY, 2014, J FUNCT FOODS, V8, P259, DOI 10.1016/j.jff.2014.03.025
   Choi SB, 2005, ENDOCRINOLOGY, V146, P4786, DOI 10.1210/en.2004-1653
   Choi YH, 2006, J PHARM SCI-US, V95, P2543, DOI 10.1002/jps.20744
   Cortez RE, 2019, J FOOD SCI, V84, P2387, DOI 10.1111/1750-3841.14781
   Dobbins RL, 2002, DIABETES, V51, P1825, DOI 10.2337/diabetes.51.6.1825
   Esposito D, 2015, J AGR FOOD CHEM, V63, P6172, DOI 10.1021/acs.jafc.5b00963
   Fallah AA, 2020, FOOD RES INT, V137, DOI 10.1016/j.foodres.2020.109379
   Gaike AH, 2020, MSYSTEMS, V5, DOI 10.1128/mSystems.00578-19
   Gopalan A, 2012, FOOD FUNCT, V3, P795, DOI 10.1039/c2fo30058c
   Gundala NKV, 2018, BIOCHEM BIOPH RES CO, V496, P105, DOI 10.1016/j.bbrc.2018.01.007
   Hong KW, 2018, NUTR RES, V51, P82, DOI 10.1016/j.nutres.2017.12.012
   Hosokawa YA, 1996, J CLIN INVEST, V97, P180, DOI 10.1172/JCI118387
   Houghton D, 2018, DIABETOLOGIA, V61, P1700, DOI 10.1007/s00125-018-4632-0
   Hui XD, 2020, FOOD RES INT, V138, DOI 10.1016/j.foodres.2020.109756
   Hyun-Jung Chung, 2019, [Food Science and Industry, 식품과학과 산업], V52, P358
   Iizuka Y, 2018, J NUTR SCI VITAMINOL, V64, P258, DOI 10.3177/jnsv.64.258
   Inaishi J, 2017, J CLIN MED, V6, DOI 10.3390/jcm6120113
   Kato M, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0126157
   Khan MAB, 2020, J EPIDEMIOL GLOB HEA, V10, P107, DOI 10.2991/jegh.k.191028.001
   Kim SN, 2019, GYNECOL OBSTET INVES, V84, P225, DOI 10.1159/000493131
   Kwon DY, 2009, J PHARMACOL SCI, V111, P361, DOI 10.1254/jphs.09178FP
   Larasati RA, 2019, BIOMEDICINES, V7, DOI 10.3390/biomedicines7040074
   Lee J, 2005, J AOAC INT, V88, P1269
   Les F, 2021, J PHYSIOL BIOCHEM, V77, P109, DOI 10.1007/s13105-020-00739-z
   Livak KJ, 2001, METHODS, V25, P402, DOI 10.1006/meth.2001.1262
   Maldonado-Contreras A, 2020, J ACAD NUTR DIET, V120, P2047, DOI 10.1016/j.jand.2020.04.018
   Marchand DK., 2020, PIOGLITAZONE TYPE 2
   Misfeldt AA, 2008, DIABETES, V57, P3069, DOI 10.2337/db08-0878
   Naseri R, 2018, FRONT PHARMACOL, V9, DOI 10.3389/fphar.2018.01310
   Nikolakopoulou P, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-29434-2
   Nolan A, 2021, EUR J NUTR, V60, P1253, DOI 10.1007/s00394-020-02329-7
   Park JH, 2015, EVID-BASED COMPL ALT, V2015, DOI 10.1155/2015/385976
   Park SM, 2007, J APPL PHYSIOL, V103, P1764, DOI 10.1152/japplphysiol.00434.2007
   Park S, 2015, GENES NUTR, V10, DOI 10.1007/s12263-015-0455-5
   Park S, 2011, EUR J NUTR, V50, P107, DOI 10.1007/s00394-010-0120-0
   Pean N, 2020, DIABETOLOGIA, V63, P1223, DOI 10.1007/s00125-020-05122-7
   REEVES PG, 1993, J NUTR, V123, P1939, DOI 10.1093/jn/123.11.1939
   Rubinskiene M, 2005, J CHROMATOGR SCI, V43, P478, DOI 10.1093/chromsci/43.9.478
   Salehidoost R, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-60142-y
   Sarwar N, 2010, LANCET, V375, P2215, DOI 10.1016/S0140-6736(10)60484-9
   Slimestad R, 2002, J AGR FOOD CHEM, V50, P3228, DOI 10.1021/jf011581u
   김미선, 2016, [Journal of Life Science, 생명과학회지], V26, P1400
   Song HZ, 2021, MOL NUTR FOOD RES, V65, DOI 10.1002/mnfr.202001090
   Takagi T, 2020, NUTRIENTS, V12, DOI 10.3390/nu12102996
   Tanase DM, 2020, NUTRIENTS, V12, DOI 10.3390/nu12123719
   Torronen R, 2012, BRIT J NUTR, V107, P1445, DOI 10.1017/S0007114511004557
   Wang XL, 2018, J DIABETES INVEST, V9, P1288, DOI 10.1111/jdi.12834
   Wu XG, 2021, NUTRIENTS, V13, DOI 10.3390/nu13020495
   Wu X, 2021, EUR J NUTR, V60, P1907, DOI 10.1007/s00394-020-02382-2
   Yildirim M, 2021, J BASIC CLIN PHYSIOL, V32, P58, DOI 10.1515/jbcpp-2020-0058
   Zhang W, 2019, BIOMED PHARMACOTHER, V118, DOI 10.1016/j.biopha.2019.109131
   Zhang WQ, 2019, J AGR FOOD CHEM, V67, P7694, DOI 10.1021/acs.jafc.9b02083
NR 55
TC 15
Z9 15
U1 0
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD MAY
PY 2021
VL 10
IS 5
AR 756
DI 10.3390/antiox10050756
PG 21
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA SG3TG
UT WOS:000653363600001
PM 34068659
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Wei, SD
   Brejnrod, AD
   Trivedi, U
   Mortensen, MS
   Johansen, MY
   Karstoft, K
   Vaag, AA
   Ried-Larsen, M
   Sorensen, SJ
AF Wei, Shaodong
   Brejnrod, Asker Daniel
   Trivedi, Urvish
   Mortensen, Martin Steen
   Johansen, Mette Yun
   Karstoft, Kristian
   Vaag, Allan Arthur
   Ried-Larsen, Mathias
   Sorensen, Soren Johannes
TI Impact of intensive lifestyle intervention on gut microbiota composition
   in type 2 diabetes: a post-hoc analysis of a randomized clinical trial
SO GUT MICROBES
LA English
DT Article
DE exercise; gut microbiota; lifestyle intervention; metformin; physical
   activity; standard care; type 2 diabetes
ID METFORMIN; OBESITY; ASSOCIATION; DATABASE; ALTERS; GENE
AB Type 2 diabetes (T2D) management is based on combined pharmacological and lifestyle intervention approaches. While their clinical benefits are well studied, less is known about their effects on the gut microbiota. We aimed to investigate if an intensive lifestyle intervention combined with conventional standard care leads to a different gut microbiota composition compared to standard care alone treatment in individuals with T2D, and if gut microbiota is associated with the clinical benefits of the treatments. Ninety-eight individuals with T2D were randomized to either an intensive lifestyle intervention combined with standard care group (N = 64), or standard care alone group (N = 34) for 12 months. All individuals received standardized, blinded, target-driven medical therapy, and individual counseling. The lifestyle intervention group moreover received intensified physical training and dietary plans. Clinical characteristics and fecal samples were collected at baseline, 3-, 6-, 9-, and 12-month follow-up. The gut microbiota was profiled with 16S rRNA gene amplicon sequencing. There were no statistical differences in the change of gut microbiota composition between treatments after 12 months, except minor and transient differences at month 3. The shift in gut microbiota alpha diversity at all time windows did not correlate with the change in clinical characteristics, and the gut microbiota did not mediate the treatment effect on clinical characteristics. The clinical benefits of intensive lifestyle and/or pharmacological interventions in T2D are unlikely to be explained by, or causally related to, changes in the gut microbiota composition.
C1 [Wei, Shaodong; Brejnrod, Asker Daniel; Trivedi, Urvish; Mortensen, Martin Steen; Sorensen, Soren Johannes] Univ Copenhagen, Dept Biol, Sect Microbiol, Univ Pk 15, DK-2100 Copenhagen, Denmark.
   [Wei, Shaodong] Tech Univ Denmark, Natl Food Inst, Lyngby, Denmark.
   [Brejnrod, Asker Daniel] Skaggs Sch Pharm & Pharmaceut Sci, La Jolla, CA USA.
   [Johansen, Mette Yun; Karstoft, Kristian; Vaag, Allan Arthur; Ried-Larsen, Mathias] Copenhagen Univ Hosp, Ctr Inflammat & Metab, Rigshosp, Copenhagen, Denmark.
   [Johansen, Mette Yun; Karstoft, Kristian; Vaag, Allan Arthur; Ried-Larsen, Mathias] Copenhagen Univ Hosp, Ctr Phys Act Res, Rigshosp, Copenhagen, Denmark.
   [Karstoft, Kristian] Univ Copenhagen, Bispebjerg Hosp, Dept Clin Pharmacol, Copenhagen, Denmark.
   [Vaag, Allan Arthur] Steno Diabet Ctr Copenhagen, Gentofte, Denmark.
C3 University of Copenhagen; Technical University of Denmark;
   Rigshospitalet; University of Copenhagen; Rigshospitalet; University of
   Copenhagen; University of Copenhagen; Bispebjerg Hospital; Steno
   Diabetes Center
RP Sorensen, SJ (通讯作者)，Univ Copenhagen, Dept Biol, Sect Microbiol, Univ Pk 15, DK-2100 Copenhagen, Denmark.
EM sjs@bio.ku.dk
RI Ried-Larsen, Mathias/GPX-7640-2022; Mortensen, Martin Steen/M-5141-2014;
   Sørensen, Søren J/J-5015-2014
OI Ried-Larsen, Mathias/0000-0002-8388-5291; Mortensen, Martin
   Steen/0000-0001-5483-7533; Sørensen, Søren J/0000-0001-6227-9906;
   Trivedi, Urvish/0000-0003-1541-6212; Karstoft,
   Kristian/0000-0002-6596-4199; Yun Johansen, Mette/0000-0001-5517-1454
FU TrygFonden [101390, 20045]; Danish National Research Foundation
   [DNRF55]; Augustinus Foundation; Rigshospitalet
FX The Center for Physical Activity Research (CFAS) is supported by grants
   from TrygFonden (grants ID 101390 and ID 20045). During the study
   period, the Center of Inflammation and Metabolism (CIM) was supported by
   a grant from the Danish National Research Foundation (DNRF55). The
   project is also supported by funding from Augustinus Foundation and
   Rigshospitalet (MYJ).
CR Amer Diabet Assoc, 2020, DIABETES CARE, V43, pS98, DOI 10.2337/dc20-S009
   Anderson MJ, 2001, AUSTRAL ECOL, V26, P32, DOI 10.1046/j.1442-9993.2001.01070.x
   [Anonymous], 1995, J R STAT SOC B
   Bairoch A, 2000, NUCLEIC ACIDS RES, V28, P304, DOI 10.1093/nar/28.1.304
   Barton W, 2018, GUT, V67, P625, DOI 10.1136/gutjnl-2016-313627
   Bolyen E, 2019, NAT BIOTECHNOL, V37, P852, DOI 10.1038/s41587-019-0209-9
   Brahe LK, 2015, BRIT J NUTR, V114, P406, DOI 10.1017/S0007114515001786
   Callahan BJ, 2016, NAT METHODS, V13, P581, DOI [10.1038/NMETH.3869, 10.1038/nmeth.3869]
   Caporaso JG, 2011, P NATL ACAD SCI USA, V108, P4516, DOI 10.1073/pnas.1000080107
   Caspi R, 2020, NUCLEIC ACIDS RES, V48, pD445, DOI 10.1093/nar/gkz862
   Cerda B, 2016, FRONT PHYSIOL, V7, DOI 10.3389/fphys.2016.00051
   Clarke SF, 2014, GUT, V63, P1913, DOI 10.1136/gutjnl-2013-306541
   Cronin O, 2018, MSYSTEMS, V3, DOI 10.1128/mSystems.00044-18
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Douglas GM, 2020, NAT BIOTECHNOL, V38, P685, DOI 10.1038/s41587-020-0548-6
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Franco OH, 2007, ARCH INTERN MED, V167, P1145, DOI 10.1001/archinte.167.11.1145
   Cano PG, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0041079
   Gong Q, 2011, DIABETOLOGIA, V54, P300, DOI 10.1007/s00125-010-1948-9
   Graf Daniela, 2015, Microbial Ecology in Health and Disease, V26, P26164, DOI 10.3402/mehd.v26.26164
   Gurung M, 2020, EBIOMEDICINE, V51, DOI 10.1016/j.ebiom.2019.11.051
   Johansen MY, 2017, JAMA-J AM MED ASSOC, V318, P637, DOI 10.1001/jama.2017.10169
   Kanehisa M, 2016, NUCLEIC ACIDS RES, V44, pD457, DOI 10.1093/nar/gkv1070
   Kern T, 2020, INT J OBESITY, V44, P125, DOI 10.1038/s41366-019-0440-y
   Klindworth A, 2013, NUCLEIC ACIDS RES, V41, DOI 10.1093/nar/gks808
   Knowler WC, 2002, NEW ENGL J MED, V346, P393, DOI 10.1056/NEJMoa012512
   Kuznetsova A, 2017, J STAT SOFTW, V82, P1, DOI 10.18637/jss.v082.i13
   Le Chatelier E, 2013, NATURE, V500, P541, DOI 10.1038/nature12506
   Lehrskov LL, 2018, CELL METAB, V27, P1201, DOI 10.1016/j.cmet.2018.04.008
   Ley RE, 2005, P NATL ACAD SCI USA, V102, P11070, DOI 10.1073/pnas.0504978102
   Ley RE, 2006, NATURE, V444, P1022, DOI 10.1038/4441022a
   Lippert K, 2017, BENEF MICROBES, V8, P545, DOI 10.3920/BM2016.0184
   Louis S, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0149564
   Lozupone C, 2005, APPL ENVIRON MICROB, V71, P8228, DOI 10.1128/AEM.71.12.8228-8235.2005
   MacDonald CS, 2020, MAYO CLIN PROC, V95, P488, DOI 10.1016/j.mayocp.2019.09.005
   MacDonald CS, 2021, BMJ OPEN DIAB RES CA, V9, DOI 10.1136/bmjdrc-2020-001840
   Magne F, 2020, NUTRIENTS, V12, DOI 10.3390/nu12051474
   Martin M., 2011, EMBNET J, V17, P10, DOI DOI 10.14806/EJ.17.1.200
   McMurdie PJ, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0061217
   Meijnikman AS, 2018, ENDOCR REV, V39, P133, DOI 10.1210/er.2017-00192
   Oksanen J, 2007, COMMUNITY ECOLOGY PA, V10, P631, DOI DOI 10.1111/J.1654-1103.2003.TB02228.X
   Quast C, 2013, NUCLEIC ACIDS RES, V41, pD590, DOI 10.1093/nar/gks1219
   Ramachandran A, 2006, DIABETOLOGIA, V49, P289, DOI 10.1007/s00125-005-0097-z
   Ried-Larsen M, 2019, DIABETES OBES METAB, V21, P2257, DOI 10.1111/dom.13802
   Ried-Larsen M, 2015, BMJ OPEN, V5, DOI 10.1136/bmjopen-2015-009764
   Salamon D, 2018, POL ARCH INTERN MED, V128, P336, DOI 10.20452/pamw.4246
   Sarangi AN, 2019, J CLIN EXP HEPATOL, V9, P62, DOI 10.1016/j.jceh.2018.04.016
   Sasaki M, 2013, BMC GASTROENTEROL, V13, DOI 10.1186/1471-230X-13-81
   Scheiman J, 2019, NAT MED, V25, P1104, DOI 10.1038/s41591-019-0485-4
   Sigal RJ, 2004, DIABETES CARE, V27, P2518, DOI 10.2337/diacare.27.10.2518
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Takai K, 2000, APPL ENVIRON MICROB, V66, P5066, DOI 10.1128/AEM.66.11.5066-5072.2000
   Taniguchi H, 2018, PHYSIOL REP, V6, DOI 10.14814/phy2.13935
   Tuomilehto J, 2001, NEW ENGL J MED, V344, P1343, DOI 10.1056/NEJM200105033441801
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Turpin-Nolan SM, 2019, NAT REV ENDOCRINOL, V15, P629, DOI 10.1038/s41574-019-0250-2
   Umpierre D, 2011, JAMA-J AM MED ASSOC, V305, P1790, DOI 10.1001/jama.2011.576
   Villanueva RAM, 2019, MEAS-INTERDISCIP RES, V17, P160, DOI 10.1080/15366367.2019.1565254
   Wang C, 2020, BIOINFORMATICS, V36, P347, DOI 10.1093/bioinformatics/btz565
   World Health Organization, 2016, GLOBAL REPORT DIABET
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Xia Y, 2021, MEDIATION ANAL MICRO, P457, DOI [10.1007/978-3-030-67951-4_16, DOI 10.1007/978-3-030-67951-4_16]
   Yamaguchi Y, 2016, DIGESTION, V94, P66, DOI 10.1159/000447690
   Yang JY, 2017, MUCOSAL IMMUNOL, V10, P104, DOI 10.1038/mi.2016.42
   Zhang J, 2018, BIOINFORMATICS, V34, P1875, DOI 10.1093/bioinformatics/bty014
   Zhang Q, 2020, DIABET METAB SYND OB, V13, P5003, DOI 10.2147/DMSO.S286430
   Zhang XY, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0071108
NR 67
TC 2
Z9 2
U1 1
U2 25
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1949-0976
EI 1949-0984
J9 GUT MICROBES
JI Gut Microbes
PD JAN 1
PY 2022
VL 14
IS 1
AR 2005407
DI 10.1080/19490976.2021.2005407
PG 15
WC Gastroenterology & Hepatology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Microbiology
GA XW6DM
UT WOS:000735707400001
PM 34965188
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Tian, PJ
   Li, BL
   He, CX
   Song, W
   Hou, AJ
   Tian, SC
   Meng, XY
   Li, KK
   Shan, YJ
AF Tian, Peijun
   Li, Baolong
   He, Canxia
   Song, Wei
   Hou, Aiju
   Tian, Sicong
   Meng, Xinyu
   Li, Kaikai
   Shan, Yujuan
TI Antidiabetic (type 2) effects of Lactobacillus G15 and Q14 in rats
   through regulation of intestinal permeability and microbiota
SO FOOD & FUNCTION
LA English
DT Article
ID TARGETING GUT MICROBIOTA; HIGH-FAT DIET; OBESITY; INFLAMMATION; MICE;
   CELLS; STREPTOZOTOCIN; PROBIOTICS; GLUCOSE; PATHOGENESIS
AB The antidiabetic effects of Lactobacillus. paracasei subsp. paracasei G15 and Lactobacillus. casei Q14 in high fat diet and streptozotocin-induced type 2 diabetic (T2D) rats were evaluated in this study. The strains were separated from Chinese traditional fermented dairy food. Administration of G15 and Q14 for 6 weeks significantly improved the glucose tolerance and reduced the HbA1c levels in T2D rats. The probiotic treatment reduced the intestinal mucosal permeability and improved the epithelial barrier function through modification of the gut microbiota, which in turn lowered circulating LPS and inflammation cytokines, including IL-1 beta and IL-8, and eventually alleviated the inflammatory status and islet beta-cell dysfunction. Combination of Q14 and metformin reversed the thymic atrophy and both G15 and Q14 lowered the circulating IL-6 level, indicating the immune-modulating potential of the strains. Lactobacillus. paracasei subsp. paracasei G15 and Lactobacillus. casei Q14 provide an insight into the biotherapy application of traditional fermented foods and their functional ingredients in the treatment of diabetes.
C1 [Tian, Peijun; He, Canxia; Song, Wei; Hou, Aiju; Tian, Sicong; Li, Kaikai; Shan, Yujuan] Harbin Inst Technol, Sch Food Sci & Engn, 73 Huanghe Rd, Harbin 150000, Peoples R China.
   [Li, Baolong; Meng, Xinyu] Heilongjiang Univ Chinese Med, Ctr Safety & Evaluat Drugs, 24 Heping Rd, Harbin 150000, Peoples R China.
C3 Harbin Institute of Technology; Heilongjiang University of Chinese
   Medicine
RP Shan, YJ (通讯作者)，Harbin Inst Technol, Sch Food Sci & Engn, 73 Huanghe Rd, Harbin 150000, Peoples R China.
EM shanyujuan@hit.edu.cn
RI Tian, Peijun/HLW-4606-2023; Li, Kai/HCI-8860-2022
OI Tian, Peijun/0000-0002-7833-1745; Song, Wei/0000-0001-6696-1208
FU Project for excellent academic leaders of Harbin Municipal Science and
   Technology Bureau [RC2014XK020002]
FX This work was financially supported by the "Project for excellent
   academic leaders of Harbin Municipal Science and Technology Bureau" (no.
   RC2014XK020002). We sincerely thank Professor Hosahalli S. Ramaswamy
   (Department of Food Science and Agricultural Chemistry, McGill
   University, Canada) for the critical reading and detailed suggestions of
   this manuscript.
CR Basu S, 2011, OBESITY, V19, P476, DOI 10.1038/oby.2010.215
   Boni-Schnetzler M, 2008, J CLIN ENDOCR METAB, V93, P4065, DOI 10.1210/jc.2008-0396
   Cani PD, 2009, GUT, V58, P1091, DOI 10.1136/gut.2008.165886
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Cani PD, 2011, PHARMACOL THERAPEUT, V130, P202, DOI 10.1016/j.pharmthera.2011.01.012
   Cavelti-Weder C, 2012, DIABETES CARE, V35, P1654, DOI 10.2337/dc11-2219
   Chassaing B, 2015, NATURE, V519, P92, DOI 10.1038/nature14232
   Chen P, 2014, NUTRITION, V30, P1061, DOI 10.1016/j.nut.2014.03.022
   Delzenne NM, 2011, NAT REV ENDOCRINOL, V7, P639, DOI 10.1038/nrendo.2011.126
   Dinarello CA, 2010, CURR OPIN ENDOCRINOL, V17, P314, DOI 10.1097/MED.0b013e32833bf6dc
   Donath MY, 2011, NAT REV IMMUNOL, V11, P98, DOI 10.1038/nri2925
   Dow LE, 2015, CELL, V161, P1539, DOI 10.1016/j.cell.2015.05.033
   Duan RS, 2013, CARBOHYD POLYM, V94, P100, DOI 10.1016/j.carbpol.2013.01.075
   Everard A, 2011, DIABETES, V60, P2775, DOI 10.2337/db11-0227
   Gomes AC, 2014, NUTR J, V13, DOI 10.1186/1475-2891-13-60
   Habib AM, 2013, DIABETOLOGIA, V56, P1413, DOI 10.1007/s00125-013-2887-z
   He CX, 2015, NUTR RES, V35, P361, DOI 10.1016/j.nutres.2015.03.002
   Hsieh FC, 2013, NUTR METAB, V10, DOI 10.1186/1743-7075-10-35
   Hu JL, 2014, J AGR FOOD CHEM, V62, P229, DOI 10.1021/jf4040942
   Kahn SE, 2014, LANCET, V383, P1068, DOI 10.1016/S0140-6736(13)62154-6
   Katakura K, 2005, J CLIN INVEST, V115, P695, DOI 10.1172/JCI200522996
   Kojima H, 2004, P NATL ACAD SCI USA, V101, P2458, DOI 10.1073/pnas.0308690100
   Kurundkar AR, 2010, PEDIATR RES, V68, P128, DOI 10.1203/00006450-201011001-00247
   Manaer T, 2015, J ETHNOPHARMACOL, V169, P269, DOI 10.1016/j.jep.2015.04.032
   Moreno-Navarrete JM, 2013, DIABETOLOGIA, V56, P2524, DOI 10.1007/s00125-013-3015-9
   Martino H., 2015, FASEB J S1, V29, P922
   Meng, 2016, EVIDENCE BASED COMPL, V2016, P4701980
   Motoo Yoshiharu, 2004, JOP, V5, P138
   Muccioli GG, 2010, MOL SYST BIOL, V6, DOI 10.1038/msb.2010.46
   Musso G, 2011, ANNU REV MED, V62, P361, DOI 10.1146/annurev-med-012510-175505
   Nicholson JK, 2012, SCIENCE, V336, P1262, DOI 10.1126/science.1223813
   Pickup JC, 2004, DIABETES CARE, V27, P813, DOI 10.2337/diacare.27.3.813
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Razmpoosh E, 2016, DIABETES-METAB RES, V32, P143, DOI 10.1002/dmrr.2665
   Reed MJ, 2000, METABOLISM, V49, P1390, DOI 10.1053/meta.2000.17721
   Selvin E, 2010, NEW ENGL J MED, V362, P800, DOI 10.1056/NEJMoa0908359
   SMITH SM, 1986, J INFECT DIS, V154, P658, DOI 10.1093/infdis/154.4.658
   Spranger J, 2003, DIABETES, V52, P812, DOI 10.2337/diabetes.52.3.812
   Srinivasan K, 2007, INDIAN J MED RES, V125, P451
   Su HC, 2014, SCI TOTAL ENVIRON, V490, P708, DOI 10.1016/j.scitotenv.2014.05.060
   Thaler JP, 2010, ENDOCRINOLOGY, V151, P4109, DOI 10.1210/en.2010-0336
   Tuo YF, 2011, WORLD J MICROB BIOT, V27, P505, DOI 10.1007/s11274-010-0482-8
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Walsh MD, 2013, MODERN PATHOL, V26, P1642, DOI 10.1038/modpathol.2013.101
   Wang J, 2015, SCI REP, V5
   Wang SM, 2014, RES MICROBIOL, V165, P202, DOI 10.1016/j.resmic.2014.02.004
   Wlodarska M, 2014, CELL, V156, P1045, DOI 10.1016/j.cell.2014.01.026
   World Health Organization, 2011, USE GLYCATED HAEMOGL
   Zhang XJ, 2014, CURR MICROBIOL, V69, P365, DOI 10.1007/s00284-014-0592-x
   Zhang YC, 2010, RES MICROBIOL, V161, P667, DOI [10.1016/J.resmic.2010.06.005, 10.1016/j.resmic.2010.06.005]
   Zhang Y, 2014, SCI REP-UK, V4, DOI 10.1038/srep05654
   Zimmermann HW, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0021381
NR 52
TC 72
Z9 77
U1 1
U2 53
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PY 2016
VL 7
IS 9
BP 3789
EP 3797
DI 10.1039/c6fo00831c
PG 9
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA DX3DS
UT WOS:000384254100014
PM 27713957
DA 2023-06-08
ER

PT J
AU Tilg, H
   Moschen, AR
AF Tilg, Herbert
   Moschen, Alexander R.
TI Microbiota and diabetes: an evolving relationship
SO GUT
LA English
DT Article
ID DIET-INDUCED OBESITY; CHAIN FATTY-ACIDS; PROTEIN-COUPLED RECEPTOR; HUMAN
   GUT MICROBIOTA; INSULIN-RESISTANCE; WEIGHT-LOSS;
   AKKERMANSIA-MUCINIPHILA; METABOLIC-SYNDROME; COMMENSAL BACTERIA;
   BODY-WEIGHT
AB The gut microbiota affects numerous biological functions throughout the body and its characterisation has become a major research area in biomedicine. Recent studies have suggested that gut bacteria play a fundamental role in diseases such as obesity, diabetes and cardiovascular disease. Data are accumulating in animal models and humans suggesting that obesity and type 2 diabetes (T2D) are associated with a profound dysbiosis. First human metagenome-wide association studies demonstrated highly significant correlations of specific intestinal bacteria, certain bacterial genes and respective metabolic pathways with T2D. Importantly, especially butyrate-producing bacteria such as Roseburia intestinalis and Faecalibacterium prausnitzii concentrations were lower in T2D subjects. This supports the increasing evidence, that butyrate and other short-chain fatty acids are able to exert profound immunometabolic effects. Endotoxaemia, most likely gut-derived has also been observed in patients with metabolic syndrome and T2D and might play a key role in metabolic inflammation. A further hint towards an association between microbiota and T2D has been derived from studies in pregnancy showing that major gut microbial shifts occurring during pregnancy affect host metabolism. Interestingly, certain antidiabetic drugs such as metformin also interfere with the intestinal microbiota. Specific members of the microbiota such as Akkermansia muciniphila might be decreased in diabetes and when administered to murines exerted antidiabetic effects. Therefore, as a 'gut signature' becomes more evident in T2D, a better understanding of the role of the microbiota in diabetes might provide new aspects regarding its pathophysiological relevance and pave the way for new therapeutic principles.
C1 [Tilg, Herbert; Moschen, Alexander R.] Med Univ Innsbruck, Dept Internal Med Gastroenterol Endocrinol & Meta, A-6020 Innsbruck, Austria.
C3 Medical University of Innsbruck
RP Tilg, H (通讯作者)，Med Univ Innsbruck, Dept Internal Med Gastroenterol Endocrinol & Meta, A-6020 Innsbruck, Austria.
EM herbert.tilg@i-med.ac.at
RI Moschen, Alexander/ABF-2267-2021
OI Moschen, Alexander R/0000-0003-3598-7848
CR Amar J, 2011, DIABETOLOGIA, V54, P3055, DOI 10.1007/s00125-011-2329-8
   Amar J, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0054461
   Amar J, 2011, EMBO MOL MED, V3, P559, DOI 10.1002/emmm.201100159
   Arpaia N, 2013, NATURE, V504, P451, DOI 10.1038/nature12726
   Backhed F, 2004, P NATL ACAD SCI USA, V101, P15718, DOI 10.1073/pnas.0407076101
   Backhed F, 2007, P NATL ACAD SCI USA, V104, P979, DOI 10.1073/pnas.0605374104
   Bindels LB, 2012, BRIT J CANCER, V107, P1337, DOI 10.1038/bjc.2012.409
   Breen DM, 2013, DIABETES, V62, P3005, DOI 10.2337/db13-0523
   Brown AJ, 2003, J BIOL CHEM, V278, P11312, DOI 10.1074/jbc.M211609200
   Burcelin R, 2013, DIABETES OBES METAB, V15, P61, DOI 10.1111/dom.12157
   Burcelin R, 2012, PHYSIOLOGY, V27, P300, DOI 10.1152/physiol.00023.2012
   Cabreiro F, 2013, CELL, V153, P228, DOI 10.1016/j.cell.2013.02.035
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   Collado MC, 2008, AM J CLIN NUTR, V88, P894, DOI 10.1093/ajcn/88.4.894
   Costello EK, 2009, SCIENCE, V326, P1694, DOI 10.1126/science.1177486
   Cotillard A, 2013, NATURE, V500, P585, DOI 10.1038/nature12480
   David LA, 2014, NATURE, V505, P559, DOI 10.1038/nature12820
   De Filippo C, 2010, P NATL ACAD SCI USA, V107, P14691, DOI 10.1073/pnas.1005963107
   De Vadder F, 2014, CELL, V156, P84, DOI 10.1016/j.cell.2013.12.016
   Derrien M, 2004, INT J SYST EVOL MICR, V54, P1469, DOI 10.1099/ijs.0.02873-0
   Devkota S, 2012, NATURE, V487, P104, DOI 10.1038/nature11225
   Donath MY, 2011, NAT REV IMMUNOL, V11, P98, DOI 10.1038/nri2925
   Duncan SH, 2008, INT J OBESITY, V32, P1720, DOI 10.1038/ijo.2008.155
   Eckburg PB, 2005, SCIENCE, V308, P1635, DOI 10.1126/science.1110591
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Everard A, 2011, DIABETES, V60, P2775, DOI 10.2337/db11-0227
   Flint HJ, 2008, NAT REV MICROBIOL, V6, P121, DOI 10.1038/nrmicro1817
   Flint HJ, 2012, NAT REV GASTRO HEPAT, V9, P577, DOI 10.1038/nrgastro.2012.156
   Furet JP, 2010, DIABETES, V59, P3049, DOI 10.2337/db10-0253
   Furusawa Y, 2013, NATURE, V504, P446, DOI 10.1038/nature12721
   Ganesh BP, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0074963
   Giongo A, 2011, ISME J, V5, P82, DOI 10.1038/ismej.2010.92
   Hansen CHF, 2012, DIABETOLOGIA, V55, P2285, DOI 10.1007/s00125-012-2564-7
   Henao-Mejia J, 2012, NATURE, V482, P179, DOI 10.1038/nature10809
   Huttenhower C, 2012, NATURE, V486, P207, DOI 10.1038/nature11234
   Islam KBMS, 2011, GASTROENTEROLOGY, V141, P1773, DOI 10.1053/j.gastro.2011.07.046
   Jakobsdottir G, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0080476
   Johnson AMF, 2013, CELL, V152, P673, DOI 10.1016/j.cell.2013.01.041
   Kang CS, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0076520
   Karlsson CLJ, 2012, OBESITY, V20, P2257, DOI 10.1038/oby.2012.110
   Karlsson F, 2013, DIABETES, V62, P3341, DOI 10.2337/db13-0844
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kau AL, 2011, NATURE, V474, P327, DOI 10.1038/nature10213
   Kimura I, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms2852
   Koren O, 2012, CELL, V150, P470, DOI 10.1016/j.cell.2012.07.008
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Lassenius MI, 2011, DIABETES CARE, V34, P1809, DOI 10.2337/dc10-2197
   Le Chatelier E, 2013, NATURE, V500, P541, DOI 10.1038/nature12506
   Le Poul E, 2003, J BIOL CHEM, V278, P25481, DOI 10.1074/jbc.M301403200
   Lepage P, 2013, GUT, V62, P146, DOI 10.1136/gutjnl-2011-301805
   Ley RE, 2005, P NATL ACAD SCI USA, V102, P11070, DOI 10.1073/pnas.0504978102
   Ley RE, 2006, NATURE, V444, P1022, DOI 10.1038/4441022a
   MENDELOFF AI, 1977, NEW ENGL J MED, V297, P811, DOI 10.1056/NEJM197710132971506
   Moller DE, 2005, ANNU REV MED, V56, P45, DOI 10.1146/annurev.med.56.082103.104751
   Moschen AR, 2012, GUT LIVER, V6, P411, DOI 10.5009/gnl.2012.6.4.411
   Moschen AR, 2011, MOL MED, V17, P840, DOI 10.2119/molmed.2010.00108
   Moschen AR, 2010, GUT, V59, P1259, DOI 10.1136/gut.2010.214577
   Mukhopadhya I, 2012, NAT REV GASTRO HEPAT, V9, P219, DOI 10.1038/nrgastro.2012.14
   Murri M, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-46
   Pussinen PJ, 2011, DIABETES CARE, V34, P392, DOI 10.2337/dc10-1676
   Pyra KA, 2012, J NUTR, V142, P213, DOI 10.3945/jn.111.147132
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Qin JJ, 2010, NATURE, V464, P59, DOI 10.1038/nature08821
   RAY TK, 1983, AM J CLIN NUTR, V37, P376, DOI 10.1093/ajcn/37.3.376
   Remely M, 2014, GENE, V537, P85, DOI 10.1016/j.gene.2013.11.081
   Ridaura VK, 2013, SCIENCE, V341, P1079, DOI 10.1126/science.1241214
   Robertson MD, 2005, AM J CLIN NUTR, V82, P559, DOI 10.1093/ajcn/82.3.559
   Robertson MD, 2003, DIABETOLOGIA, V46, P659, DOI 10.1007/s00125-003-1081-0
   Sahin M, 2007, J DIABETES COMPLICAT, V21, P118, DOI 10.1016/j.jdiacomp.2005.10.005
   Samuel BS, 2008, P NATL ACAD SCI USA, V105, P16767, DOI 10.1073/pnas.0808567105
   Santacruz A, 2010, BRIT J NUTR, V104, P83, DOI 10.1017/S0007114510000176
   Schwiertz A, 2010, OBESITY, V18, P190, DOI 10.1038/oby.2009.167
   Serino M, 2012, GUT, V61, P543, DOI 10.1136/gutjnl-2011-301012
   Shanahan F, 2012, NAT REV GASTRO HEPAT, V9, P609, DOI 10.1038/nrgastro.2012.145
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Smith PM, 2013, SCIENCE, V341, P569, DOI 10.1126/science.1241165
   Stienstra R, 2010, CELL METAB, V12, P593, DOI 10.1016/j.cmet.2010.11.011
   Swann JR, 2011, P NATL ACAD SCI USA, V108, P4523, DOI 10.1073/pnas.1006734107
   Tilg H, 2008, MOL MED, V14, P222, DOI 10.2119/2007-00119.Tilg
   Tilg H, 2011, J CLIN INVEST, V121, P2126, DOI 10.1172/JCI58109
   Tolhurst G, 2012, DIABETES, V61, P364, DOI 10.2337/db11-1019
   Tremaroli V, 2012, NATURE, V489, P242, DOI 10.1038/nature11552
   Trompette A, 2014, NAT MED, V20, P159, DOI 10.1038/nm.3444
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Turnbaugh PJ, 2009, NATURE, V457, P480, DOI 10.1038/nature07540
   Vijay-Kumar M, 2010, SCIENCE, V328, P228, DOI 10.1126/science.1179721
   Vrieze A, 2012, GASTROENTEROLOGY, V143, P913, DOI 10.1053/j.gastro.2012.06.031
   Walker AW, 2011, ISME J, V5, P220, DOI 10.1038/ISMEJ.2010.118
   Wu GD, 2011, SCIENCE, V334, P105, DOI 10.1126/science.1208344
   Yoon JC, 2000, MOL CELL BIOL, V20, P5343, DOI 10.1128/MCB.20.14.5343-5349.2000
   Yoshimoto S, 2013, NATURE, V499, P97, DOI 10.1038/nature12347
   Zhang XY, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0071108
NR 93
TC 492
Z9 541
U1 18
U2 322
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0017-5749
EI 1468-3288
J9 GUT
JI Gut
PD SEP
PY 2014
VL 63
IS 9
BP 1513
EP 1521
DI 10.1136/gutjnl-2014-306928
PG 9
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA AO0QC
UT WOS:000341014600023
PM 24833634
HC Y
HP N
DA 2023-06-08
ER

PT J
AU Song, M
   Chan, AT
AF Song, Mingyang
   Chan, Andrew T.
TI Environmental Factors, Gut Microbiota, and Colorectal Cancer Prevention
SO CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
LA English
DT Review
DE Young-Onset Colorectal Cancer; Nutrition; Clinical Trial;
   Chemoprevention
ID POLYUNSATURATED FATTY-ACIDS; HIGH-FIBER DIET; FUSOBACTERIUM-NUCLEATUM;
   INTESTINAL MICROBIOTA; RANDOMIZED TRIAL; MUCUS BARRIER; LINOLEIC-ACID;
   MOUSE MODEL; BILE-ACIDS; VITAMIN-D
AB The substantial burden of colorectal cancer and increasing trend in young adults highlight the importance of lifestyle modification as a complement to screening for colorectal cancer prevention. Several dietary and lifestyle factors have been implicated in the development of colorectal cancer, possibly through the intricate metabolic and inflammatory mechanisms. Likewise, as a key metabolic and immune regulator, the gut microbiota has been recognized to play an important role in colorectal tumorigenesis. Increasing data support that environmental factors are crucial determinants for the gut microbial composition and function, whose alterations induce changes in the host gene expression, metabolic regulation, and local and systemic immune response, thereby influencing cancer development. Here, we review the epidemiologic and mechanistic evidence regarding the links between diet and lifestyle and the gut microbiota in the development of colorectal cancer. We focus on factors for which substantial data support their importance for colorectal cancer and their potential role in the gut microbiota, including overweight and obesity, physical activity, dietary patterns, fiber, red and processed meat, marine omega-3 fatty acid, alcohol, and smoking. We also briefly describe other colorectal cancer-preventive factors for which the links with the gut microbiota have been suggested but remain to be mechanistically characterized, including vitamin D status, dairy consumption, and metformin use. Given limitations in available evidence, we highlight the need for further investigations in the relationship between environmental factors, gut microbiota, and colorectal cancer, which may lead to development and clinical translation of potential microbiota-based strategies for cancer prevention.
C1 [Song, Mingyang] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, 677 Huntington Ave,Kresge 906A, Boston, MA 02115 USA.
   [Song, Mingyang] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA.
   [Song, Mingyang; Chan, Andrew T.] Massachusetts Gen Hosp, Clin & Translat Epidemiol Unit, Boston, MA 02114 USA.
   [Song, Mingyang; Chan, Andrew T.] Harvard Med Sch, Boston, MA USA.
   [Song, Mingyang; Chan, Andrew T.] Massachusetts Gen Hosp, Div Gastroenterol, Boston, MA 02114 USA.
   [Chan, Andrew T.] Broad Inst Massachusetts Inst Technol & Harvard, Cambridge, MA USA.
   [Chan, Andrew T.] Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA.
   [Chan, Andrew T.] Harvard TH Chan Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA USA.
C3 Harvard University; Harvard T.H. Chan School of Public Health; Harvard
   University; Harvard T.H. Chan School of Public Health; Harvard
   University; Massachusetts General Hospital; Harvard University; Harvard
   Medical School; Harvard University; Massachusetts General Hospital;
   Harvard University; Massachusetts Institute of Technology (MIT); Broad
   Institute; Harvard University; Brigham & Women's Hospital; Harvard
   University; Harvard T.H. Chan School of Public Health
RP Song, M (通讯作者)，Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, 677 Huntington Ave,Kresge 906A, Boston, MA 02115 USA.
EM msong2@mgh.harvard.edu
RI Song, Mingyang/M-6701-2013
OI Song, Mingyang/0000-0002-1324-0316
FU American Cancer Society [MRSG-17-220-01 -NEC]; AACR-AstraZeneca
   Fellowship in Immuno-oncology Research [17-40-12-SONG]; National
   Institutes of Health [K99 CA215314, R00 CA215314, K24 DK098311, R01
   CA137178, R01 CA202704, R01 CA176726]
FX This work was supported by the American Cancer Society (MRSG-17-220-01
   -NEC to M.S.), an AACR-AstraZeneca Fellowship in Immuno-oncology
   Research (17-40-12-SONG to M.S.), and by the National Institutes of
   Health (K99 CA215314 and R00 CA215314 to M.S.; K24 DK098311, R01
   CA137178, R01 CA202704, R01 CA176726 to A.T.C.). Dr. Chan is a Stuart
   and Suzanne Steele MGH Research Scholar.
CR Abrahami D, 2018, EPIDEMIOLOGY, V29, P246, DOI 10.1097/EDE.0000000000000793
   Ahn J, 2013, JNCI-J NATL CANCER I, V105, P1907, DOI 10.1093/jnci/djt300
   Alberts DS, 2000, NEW ENGL J MED, V342, P1156, DOI 10.1056/NEJM200004203421602
   Allais L, 2016, ENVIRON MICROBIOL, V18, P1352, DOI 10.1111/1462-2920.12934
   Allali I, 2015, GUT MICROBES, V6, P161, DOI 10.1080/19490976.2015.1039223
   Anderson AC, 2016, IMMUNITY, V44, P989, DOI 10.1016/j.immuni.2016.05.001
   Barton W, 2018, GUT, V67, P625, DOI 10.1136/gutjnl-2016-313627
   Belenguer A, 2006, APPL ENVIRON MICROB, V72, P3593, DOI 10.1128/AEM.72.5.3593-3599.2006
   Benjamin JL, 2012, INFLAMM BOWEL DIS, V18, P1092, DOI 10.1002/ibd.21864
   Biedermann L, 2014, INFLAMM BOWEL DIS, V20, P1496, DOI 10.1097/MIB.0000000000000129
   Bonithon-Kopp C, 2000, LANCET, V356, P1300, DOI 10.1016/S0140-6736(00)02813-0
   Budden KF, 2017, NAT REV MICROBIOL, V15, P55, DOI 10.1038/nrmicro.2016.142
   Bull-Otterson L, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0053028
   Bullman S, 2017, SCIENCE, V358, P1443, DOI 10.1126/science.aal5240
   Caesar R, 2015, CELL METAB, V22, P658, DOI 10.1016/j.cmet.2015.07.026
   Campbell EL, 2010, P NATL ACAD SCI USA, V107, P14298, DOI 10.1073/pnas.0914730107
   Cani PD, 2018, NAT REV GASTROENTERO
   Castellarin M, 2012, GENOME RES, V22, P299, DOI 10.1101/gr.126516.111
   Chen WHC, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0039039
   Clarke SF, 2014, GUT, V63, P1913, DOI 10.1136/gutjnl-2013-306541
   Cockbain AJ, 2012, GUT, V61, P135, DOI 10.1136/gut.2010.233718
   Cockbain AJ, 2014, GUT, V63, P1760, DOI 10.1136/gutjnl-2013-306445
   DECOSSE JJ, 1989, JNCI-J NATL CANCER I, V81, P1290, DOI 10.1093/jnci/81.17.1290
   Desai MS, 2016, CELL, V167, P1339, DOI 10.1016/j.cell.2016.10.043
   Desbois AP, 2010, APPL MICROBIOL BIOT, V85, P1629, DOI 10.1007/s00253-009-2355-3
   Devkota S, 2012, NATURE, V487, P104, DOI 10.1038/nature11225
   Donohoe DR, 2014, CANCER DISCOV, V4, P1387, DOI 10.1158/2159-8290.CD-14-0501
   Druart C, 2015, MOL NUTR FOOD RES, V59, P1603, DOI 10.1002/mnfr.201500014
   Druart C, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0087560
   Dubinkina VB, 2017, MICROBIOME, V5, DOI 10.1186/s40168-017-0359-2
   Duncan SH, 2004, APPL ENVIRON MICROB, V70, P5810, DOI 10.1128/AEM.70.10.5810-5817.2004
   Eikawa S, 2015, P NATL ACAD SCI USA, V112, P1809, DOI 10.1073/pnas.1417636112
   Evans CC, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0092193
   Feng Q, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms7528
   Feng YL, 2017, EUR J CANCER PREV, V26, P201, DOI 10.1097/CEJ.0000000000000245
   Flint HJ, 2015, P NUTR SOC, V74, P13, DOI 10.1017/S0029665114001463
   Furumoto H, 2016, TOXICOL APPL PHARM, V296, P1, DOI 10.1016/j.taap.2016.02.012
   Gandini S, 2014, CANCER PREV RES, V7, P867, DOI 10.1158/1940-6207.CAPR-13-0424
   Garrett WS, 2015, SCIENCE, V348, P80, DOI 10.1126/science.aaa4972
   Ghosh S, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0055468
   Gong J, 2012, CANCER EPIDEM BIOMAR, V21, P1974, DOI 10.1158/1055-9965.EPI-12-0692
   Gopalakrishnan V, 2018, SCIENCE, V359, P97, DOI 10.1126/science.aan4236
   Gur C, 2015, IMMUNITY, V42, P344, DOI 10.1016/j.immuni.2015.01.010
   Higurashi T, 2016, LANCET ONCOL, V17, P475, DOI 10.1016/S1470-2045(15)00565-3
   Hirata A, 2015, J LIPID RES, V56, P1340, DOI 10.1194/jlr.M059444
   Holscher HD, 2015, AM J CLIN NUTR, V101, P55, DOI 10.3945/ajcn.114.092064
   Hu JQ, 2015, AN ACAD BRAS CIENC, V87, P997, DOI 10.1590/0001-3765201520140518
   Iida N, 2013, SCIENCE, V342, P967, DOI 10.1126/science.1240527
   Ijssennagger N, 2015, P NATL ACAD SCI USA, V112, P10038, DOI 10.1073/pnas.1507645112
   Queipo-Ortuno MI, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0065465
   Islami F, 2018, CA-CANCER J CLIN, V68, P31, DOI 10.3322/caac.21440
   Jenq RR, 2012, J EXP MED, V209, P902, DOI 10.1084/jem.20112408
   Kaliannan K, 2016, INT J OBESITY, V40, P1039, DOI 10.1038/ijo.2016.27
   Kaliannan K, 2015, SCI REP-UK, V5, DOI 10.1038/srep11276
   Kau AL, 2011, NATURE, V474, P327, DOI 10.1038/nature10213
   Keren N, 2015, ENV MICROBIOL REP, V7, P874, DOI 10.1111/1758-2229.12319
   Khan MT, 2014, CELL METAB, V20, P753, DOI 10.1016/j.cmet.2014.07.006
   Khazaie K, 2012, P NATL ACAD SCI USA, V109, P10462, DOI 10.1073/pnas.1207230109
   Kishino S, 2013, P NATL ACAD SCI USA, V110, P17808, DOI 10.1073/pnas.1312937110
   Kishino S, 2009, APPL MICROBIOL BIOT, V84, P87, DOI 10.1007/s00253-009-1949-0
   Koehler JA, 2015, CELL METAB, V21, P379, DOI 10.1016/j.cmet.2015.02.005
   Kong SY, 2016, CANCER EPIDEM BIOMAR, V25, P291, DOI 10.1158/1055-9965.EPI-15-0798
   Kostic AD, 2013, CELL HOST MICROBE, V14, P207, DOI 10.1016/j.chom.2013.07.007
   Kostic AD, 2012, GENOME RES, V22, P292, DOI 10.1101/gr.126573.111
   Leclercq S, 2014, P NATL ACAD SCI USA, V111, pE4485, DOI 10.1073/pnas.1415174111
   Li RF, 2018, CELL REP, V22, P624, DOI 10.1016/j.celrep.2017.12.071
   Li RF, 2014, CELL METAB, V19, P702, DOI 10.1016/j.cmet.2014.03.012
   LINOS DA, 1981, LANCET, V2, P379
   Loo TM, 2017, CANCER DISCOV, V7, P522, DOI 10.1158/2159-8290.CD-16-0932
   Ma YL, 2011, J CLIN ONCOL, V29, P3775, DOI 10.1200/JCO.2011.35.7566
   MACLENNAN R, 1995, J NATL CANCER I, V87, P1760, DOI 10.1093/jnci/87.23.1760
   Matson V, 2018, SCIENCE, V359, P104, DOI 10.1126/science.aao3290
   Matsumoto M, 2008, BIOSCI BIOTECH BIOCH, V72, P572, DOI 10.1271/bbb.70474
   McCoy AN, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0053653
   McCullough ML, 2018, J NATL CANC I
   MCKEOWNEYSSEN GE, 1994, J CLIN EPIDEMIOL, V47, P525, DOI 10.1016/0895-4356(94)90299-2
   Mehta RS, 2017, JAMA ONCOL, V3, P921, DOI 10.1001/jamaoncol.2016.6374
   Mima K, 2016, GUT, V65, P1973, DOI 10.1136/gutjnl-2015-310101
   Mima K, 2015, JAMA ONCOL, V1, P653, DOI 10.1001/jamaoncol.2015.1377
   Miyamoto J, 2015, J BIOL CHEM, V290, P2902, DOI 10.1074/jbc.M114.610733
   Mujico JR, 2013, BRIT J NUTR, V110, P711, DOI 10.1017/S0007114512005612
   Mutlu EA, 2012, AM J PHYSIOL-GASTR L, V302, pG966, DOI 10.1152/ajpgi.00380.2011
   Nakatsu G, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms9727
   Noriega BS, 2016, CASE REP MED, V2016, DOI 10.1155/2016/3089303
   Nosova T, 1996, ALCOHOL ALCOHOLISM, V31, P555
   O'Keefe SJD, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms7342
   Ogden CL, 2010, NATL VITAL STAT REPO, P1
   Ogden Cynthia L, 2015, NCHS Data Brief, P1
   Ohtani N, 2014, CANCER RES, V74, P1885, DOI 10.1158/0008-5472.CAN-13-3501
   Ou JH, 2013, AM J CLIN NUTR, V98, P111, DOI 10.3945/ajcn.112.056689
   Paleari L, 2018, GASTROENTEROLOGY, V154, P1543, DOI 10.1053/j.gastro.2017.12.040
   Patterson E, 2014, BRIT J NUTR, V111, P1905, DOI 10.1017/S0007114514000117
   Peran L, 2007, BRIT J NUTR, V97, P96, DOI 10.1017/S0007114507257770
   Petriz BA, 2014, BMC GENOMICS, V15, DOI 10.1186/1471-2164-15-511
   Pitcher MCL, 2000, GUT, V46, P64, DOI 10.1136/gut.46.1.64
   POMARE EW, 1973, GUT, V14, P753, DOI 10.1136/gut.14.10.753
   Prossomariti A, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-07992-1
   Qin YF, 2018, GENOME BIOL, V19, DOI 10.1186/s13059-018-1389-1
   Roediger WEW, 1997, DIGEST DIS SCI, V42, P1571, DOI 10.1023/A:1018851723920
   Rothschild D, 2018, NATURE, V555, P210, DOI 10.1038/nature25973
   Rubinstein MR, 2013, CELL HOST MICROBE, V14, P195, DOI 10.1016/j.chom.2013.07.012
   Sakurama H, 2014, J LIPID RES, V55, P1855, DOI 10.1194/jlr.M045450
   Schatzkin A, 2000, NEW ENGL J MED, V342, P1149, DOI 10.1056/NEJM200004203421601
   Schroeder BO, 2018, CELL HOST MICROBE, V23, P27, DOI 10.1016/j.chom.2017.11.004
   Sears CL, 2014, CELL HOST MICROBE, V15, P317, DOI 10.1016/j.chom.2014.02.007
   Shabanzadeh DM, 2017, GASTROENTEROLOGY, V152, P1965, DOI 10.1053/j.gastro.2017.02.013
   Shen W, 2014, J NUTR BIOCHEM, V25, P270, DOI 10.1016/j.jnutbio.2013.09.009
   Siegel RL, 2017, CA-CANCER J CLIN, V67, P177, DOI 10.3322/caac.21395
   Siegel RL, 2017, JNCI-J NATL CANCER I, V109, P1974, DOI DOI 10.1093/JNCI/DJW322
   Singh N, 2014, IMMUNITY, V40, P128, DOI 10.1016/j.immuni.2013.12.007
   Sivan A, 2015, SCIENCE, V350, P1084, DOI 10.1126/science.aac4255
   Smith PM, 2013, SCIENCE, V341, P569, DOI 10.1126/science.1241165
   So D, 2018, AM J CLIN NUTR, V107, P965, DOI 10.1093/ajcn/nqy041
   Song MY, 2018, JAMA ONCOL, V4, P71, DOI 10.1001/jamaoncol.2017.3684
   Song MY, 2017, GUT, V66, P1790, DOI 10.1136/gutjnl-2016-311990
   Song MY, 2016, JAMA ONCOL, V2, P1154, DOI 10.1001/jamaoncol.2016.0843
   Song MY, 2015, GASTROENTEROLOGY, V148, P1244, DOI 10.1053/j.gastro.2014.12.035
   Song MY, 2014, INT J CANCER, V135, P2413, DOI 10.1002/ijc.28878
   Tahara T, 2014, CANCER RES, V74, P1311, DOI 10.1158/0008-5472.CAN-13-1865
   Thomas C, 2009, CELL METAB, V10, P167, DOI 10.1016/j.cmet.2009.08.001
   Tilg H, 2018, CANCER CELL, V33, P954, DOI 10.1016/j.ccell.2018.03.004
   Tomoda K, 2011, J TOXICOL SCI, V36, P261, DOI 10.2131/jts.36.261
   Tsuruya A, 2016, ALCOHOL ALCOHOLISM, V51, P395, DOI 10.1093/alcalc/agv135
   Tsuruya A, 2016, SCI REP-UK, V6, DOI 10.1038/srep27923
   Van Blarigan EL, 2018, CANCER EPIDEM BIOMAR, V27, P438, DOI [10.1158/1055-9965.EPI-17-0689, 10.1158/1055-9965.epi-17-0689]
   Veiga P, 2014, SCI REP-UK, V4, DOI 10.1038/srep06328
   Vogelaar I, 2006, CANCER-AM CANCER SOC, V107, P1624, DOI 10.1002/cncr.22115
   Wahlstrom A, 2016, CELL METAB, V24, P41, DOI 10.1016/j.cmet.2016.05.005
   Wang J, 2016, NAT GENET, V48, P1396, DOI 10.1038/ng.3695
   Watson H., 2017, GUT
   West NJ, 2010, GUT, V59, P918, DOI 10.1136/gut.2009.200642
   Wolf AMD, 2018, CA-CANCER J CLIN, V68, P250, DOI 10.3322/caac.21457
   Woo SR, 2012, CANCER RES, V72, P917, DOI 10.1158/0008-5472.CAN-11-1620
   World Cancer Research Fund/American Insitute for Cancer Research, 2007, FOOD NUTR PHYS ACT P
   World Cancer Research Fund International/American Institute for Cancer Research, CONT UPD PROJ REP DI
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Wu P, 2015, PLOS ONE, V10
   Xie GX, 2013, J PROTEOME RES, V12, P3297, DOI 10.1021/pr400362z
   Yan AW, 2011, HEPATOLOGY, V53, P96, DOI 10.1002/hep.24018
   Yang B, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0110574
   Yazici C, 2017, GUT, V66, P1983, DOI 10.1136/gutjnl-2016-313321
   Yoshimoto S, 2013, NATURE, V499, P97, DOI 10.1038/nature12347
   Zakikhani M, 2008, CANCER PREV RES, V1, P369, DOI 10.1158/1940-6207.CAPR-08-0081
   Zhernakova A, 2016, SCIENCE, V352, P565, DOI 10.1126/science.aad3369
NR 144
TC 130
Z9 135
U1 29
U2 124
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1542-3565
EI 1542-7714
J9 CLIN GASTROENTEROL H
JI Clin. Gastroenterol. Hepatol.
PD JAN
PY 2019
VL 17
IS 2
BP 275
EP 289
DI 10.1016/j.cgh.2018.07.012
PG 15
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA HF8UK
UT WOS:000454517500006
PM 30031175
OA Green Accepted
HC Y
HP N
DA 2023-06-08
ER

PT J
AU Umirah, F
   Neoh, CF
   Ramasamy, K
   Lim, SM
AF Umirah, Fatin
   Neoh, Chin Fen
   Ramasamy, Kalavathy
   Lim, Siong Meng
TI Differential gut microbiota composition between type 2 diabetes mellitus
   patients and healthy controls: A systematic review
SO DIABETES RESEARCH AND CLINICAL PRACTICE
LA English
DT Review
DE Dysbiosis; Metagenome; Microbiome; Type 2 diabetes mellitus
ID ASSOCIATION; METAGENOME; METABOLISM; BACTERIA; OBESITY; WOMEN
AB Aims: This systematic review summarised the latest findings on differential composition of gut microbiota in T2DM.
   Methods: Literature search was performed using electronic databases. Relevant studies were identified, extracted and assessed for risk of bias. The primary outcome of this systematic review was the composition of gut microbiota in healthy controls and T2DM while the secondary outcomes included the correlation of gut microbiota with metabolic parameters.
   Results: Thirteen case-control studies involving 575 T2DM and 840 healthy controls were included. T2DM patients exhibited a marked increase in lactobacilli. Six studies found lactobacilli to predominate the gut of T2DM patients; however, this could be confounded by the types of antihyperglyacemic medications. Conversely, butyrate producers dominate the gut of healthy controls. In T2DM patients, butyrate producers were surprisingly higher in those taking metformin intake than those not taking the drug. Whilst lactobacilli were found to be higher with increased plasma glucose, conflicting correlations were observed between various genera and anthropometric measurements, dietary intake, lipid profiles and inflammatory markers. There were moderate to strong significant positive correlations between the class Clostridia and phylum Firmicutes with pro-inflammatory IFN-gamma as well as between Negativicutes and IL-6.
   Conclusions: Altogether, butyrate-producing bacteria are negatively correlated to glycaemic parameters. Lactobacilli are higher in T2DM patients and Firmicutes is correlated with inflammation. (C) 2021 Elsevier B.V. All rights reserved.
C1 [Umirah, Fatin; Neoh, Chin Fen; Ramasamy, Kalavathy; Lim, Siong Meng] Univ Teknol MARA UiTM, Fac Pharm, Collaborat Drug Discovery Res CDDR Grp, Kampus Puncak Alam, Bandar Puncak Alam 42300, Selangor Darul, Malaysia.
RP Neoh, CF; Ramasamy, K (通讯作者)，Univ Teknol MARA UiTM, Fac Pharm, Collaborat Drug Discovery Res CDDR Grp, Kampus Puncak Alam, Bandar Puncak Alam 42300, Selangor Darul, Malaysia.
EM neohchinfen@uitm.edu.my; kalav922@uitm.edu.my
RI Neoh, Chin Fen/AFV-9536-2022; Ramasamy, Kala/ABA-8532-2021; Lim, Siong
   Meng/I-5697-2015
OI Neoh, Chin Fen/0000-0003-2462-2958; Lim, Siong Meng/0000-0003-1905-6584
FU Universiti Teknologi MARA (UiTM) [600-IRMI 5/3/LESTARI (016/2019)]
FX This work was funded by Universiti Teknologi MARA (UiTM) [Lestari grant:
   600-IRMI 5/3/LESTARI (016/2019)].
CR Adachi K, 2019, J CLIN BIOCHEM NUTR, V64, P231, DOI 10.3164/jcbn.18-101
   Ali F. H. A., 2013, EGYPTIAN J MED HUMAN, V14, P95, DOI [10.1016/j.ejmhg.2012.10.003, DOI 10.1016/J.EJMHG.2012.10.003]
   Aw W, 2018, J DIABETES INVEST, V9, P5, DOI 10.1111/jdi.12673
   Barcenilla A, 2000, APPL ENVIRON MICROB, V66, P1654, DOI 10.1128/AEM.66.4.1654-1661.2000
   Barrons R, 2008, CLIN THER, V30, P453, DOI 10.1016/j.clinthera.2008.03.013
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Boada CAC, 2013, NUTR HOSP, V28, P78, DOI 10.3305/nh.2013.28.sup2.6717
   Ciorba MA, 2012, CLIN GASTROENTEROL H, V10, P960, DOI 10.1016/j.cgh.2012.03.024
   Depeint F, 2008, AM J CLIN NUTR, V87, P785, DOI 10.1093/ajcn/87.3.785
   Devaraj S, 2013, CLIN CHEM, V59, P617, DOI 10.1373/clinchem.2012.187617
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Gerard C, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00029
   Gevers D, 2014, CELL HOST MICROBE, V15, P382, DOI 10.1016/j.chom.2014.02.005
   Gomez-Arango LF, 2016, DIABETES, V65, P2214, DOI 10.2337/db16-0278
   Gurung M, 2020, EBIOMEDICINE, V51, DOI 10.1016/j.ebiom.2019.11.051
   Hung W -W, 2020, GUT MICROBIOTA RELAT, V3, DOI [10.1016/j.medmic.2020.100007, DOI 10.1016/J.MEDMIC.2020.100007]
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kim SJ, 2019, BMC MICROBIOL, V19, DOI 10.1186/s12866-019-1557-9
   Krajmalnik-Brown R, 2012, NUTR CLIN PRACT, V27, P201, DOI 10.1177/0884533611436116
   La Rosa SL, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-08812-y
   Lambeth Stacey M, 2015, J Diabetes Obes, V2, P1
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Le KA, 2013, FRONT PHYSIOL, V3, DOI 10.3389/fphys.2012.00496
   Leite AZ, 2017, FRONT IMMUNOL, V8, DOI 10.3389/fimmu.2017.01107
   Lihn AS, 2005, OBES REV, V6, P13, DOI 10.1111/j.1467-789X.2005.00159.x
   Montandon SA, 2017, GENES-BASEL, V8, DOI 10.3390/genes8100250
   Navab-Moghadam F, 2017, MICROB PATHOGENESIS, V110, P630, DOI 10.1016/j.micpath.2017.07.034
   Pedro MN, 2018, DIABETOL METAB SYNDR, V10, DOI 10.1186/s13098-018-0308-7
   Pokusaeva K, 2011, GENES NUTR, V6, P285, DOI 10.1007/s12263-010-0206-6
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Rodriguez J, 2018, CURR OPIN CLIN NUTR, V21, P294, DOI 10.1097/MCO.0000000000000468
   Rotenstein LS, 2016, JAMA-J AM MED ASSOC, V316, P2214, DOI 10.1001/jama.2016.17324
   Sato J, 2014, DIABETES CARE, V37, P2343, DOI 10.2337/dc13-2817
   Schober P, 2018, ANESTH ANALG, V126, P1763, DOI 10.1213/ANE.0000000000002864
   Sedighi M, 2017, MICROB PATHOGENESIS, V111, P362, DOI 10.1016/j.micpath.2017.08.038
   Su BL, 2015, J DIABETES, V7, P729, DOI 10.1111/1753-0407.12232
   Walsh J, 2018, BRIT J PHARMACOL, V175, P4415, DOI 10.1111/bph.14366
   Watson D, 2013, J APPL MICROBIOL, V114, P1132, DOI 10.1111/jam.12105
   Wells GA., 2014, APPL ENG AGRIC, V18, P727
   Wu XK, 2010, CURR MICROBIOL, V61, P69, DOI 10.1007/s00284-010-9582-9
   Xu J, 2015, ISME J, V9, P552, DOI 10.1038/ismej.2014.177
   Zhang XY, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0071108
NR 42
TC 19
Z9 20
U1 4
U2 22
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0168-8227
EI 1872-8227
J9 DIABETES RES CLIN PR
JI Diabetes Res. Clin. Pract.
PD MAR
PY 2021
VL 173
AR 108689
DI 10.1016/j.diabres.2021.108689
EA FEB 2021
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA YY7IP
UT WOS:000754960500026
PM 33549678
DA 2023-06-08
ER

PT J
AU Gowd, V
   Xie, LH
   Zheng, XD
   Chen, W
AF Gowd, Vemana
   Xie, Lianghua
   Zheng, Xiaodong
   Chen, Wei
TI Dietary fibers as emerging nutritional factors against diabetes: focus
   on the involvement of gut microbiota
SO CRITICAL REVIEWS IN BIOTECHNOLOGY
LA English
DT Review
DE Diabetes mellitus; gut microbiota; dietary fibers; short-chain fatty
   acids; insulin sensitivity; glycemic index; GLP-1
ID CHAIN FATTY-ACIDS; INSULIN SENSITIVITY; GLUCOSE-TOLERANCE; GLYCEMIC
   LOAD; WEIGHT-LOSS; OBESE MICE; BILE-ACID; AKKERMANSIA-MUCINIPHILA;
   INTESTINAL MICROBIOTA; METFORMIN ALTERS
AB Diabetes mellitus (DM) increases the risk of cardiovascular diseases and other secondary complications, such as nephropathy, neuropathy, retinopathy, etc. The important risk factors for the pathogenesis of DM are aging, family history, sedentary lifestyle, unhealthy dietary habits, and obesity. Evidence from epidemiological studies also indicates that DM is characterized by specific alterations in the human gut microbiota (GM). GM transplantation in rodents and humans revealed that a specific GM constituent can be the cause and not just the consequence of the DM condition and complications. These findings suggest a potential role of GM in human health, disease prevention, and treatment. Dietary intervention studies using dietary fibers (DFs) suggested that modulation of the GM can suppress the metabolic risk markers in humans. However, a causal role of GM in such studies remains unexplored. Long-term follow-up studies disclosed that the diet rich in insoluble and non-viscous fibers are responsible for DF-mediated antidiabetic activities, while soluble and viscous fibers have little influence on DM despite having a profound impact on glycemia. However, general conclusions cannot be drawn simply based on these findings. Long-term follow-up studies are urgently required in this area to explore the therapeutic potential of different DFs in treating DM and to delineate the exact role of GM involvement. Here we review and discuss the signature of GM during DM, antidiabetic activity of metformin via GM modulation, DFs from different sources and their antidiabetic activity, and the possible role of GM involvement.
C1 [Gowd, Vemana; Xie, Lianghua; Zheng, Xiaodong; Chen, Wei] Zhejiang Univ, Zhejiang Key Lab Agrofood Proc, Natl Engn Lab Intelligent Food Technol & Equipmen, Dept Food Sci & Nutr, Hangzhou, Zhejiang, Peoples R China.
C3 Zhejiang University
RP Zheng, XD; Chen, W (通讯作者)，Zhejiang Univ, Dept Food Sci & Nutr, 866 Yuhangtang Rd, Hangzhou 310058, Zhejiang, Peoples R China.
EM xdzheng@zju.edu.cn; zjuchenwei@zju.edu.cn
OI gowd, vemana/0000-0003-0527-4003
FU National Key Technology R&D Program of China [2018YFD0700203]; National
   Natural Science Foundation of China [U1703105]
FX This work was supported by Grants from National Key Technology R&D
   Program of China (2018YFD0700203) and National Natural Science
   Foundation of China (U1703105).
CR An HY, 2016, J ENDOCRINOL, V228, pR97, DOI 10.1530/JOE-15-0447
   Bailey CJ, 2008, DIABETOLOGIA, V51, P1552, DOI 10.1007/s00125-008-1053-5
   Bauer PV, 2018, CELL METAB, V27, P101, DOI 10.1016/j.cmet.2017.09.019
   Bliss DZ, 1996, AM J CLIN NUTR, V63, P392, DOI 10.1093/ajcn/63.3.392
   BONORA E, 1984, CURR MED RES OPIN, V9, P47, DOI 10.1185/03007998409109558
   Brahe LK, 2015, BRIT J NUTR, V114, P406, DOI 10.1017/S0007114515001786
   Brockman DA, 2012, NUTR METAB, V9, DOI 10.1186/1743-7075-9-100
   Brownawell AM, 2012, J NUTR, V142, P962, DOI 10.3945/jn.112.158147
   Brugman S, 2006, DIABETOLOGIA, V49, P2105, DOI 10.1007/s00125-006-0334-0
   Burcelin R, 2011, ACTA DIABETOL, V48, P257, DOI 10.1007/s00592-011-0333-6
   Canfora EE, 2015, NAT REV ENDOCRINOL, V11, P577, DOI 10.1038/nrendo.2015.128
   Cani PD, 2008, DIABETOLOGIA, V51, pS34
   Cani PD, 2007, DIABETOLOGIA, V50, P2374, DOI 10.1007/s00125-007-0791-0
   Cani PD, 2009, GUT, V58, P1091, DOI 10.1136/gut.2008.165886
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   Cani PD, 2016, MOL METAB, V5, P743, DOI 10.1016/j.molmet.2016.05.011
   Cani PD, 2009, AM J CLIN NUTR, V90, P1236, DOI 10.3945/ajcn.2009.28095
   Cani PD, 2006, DIABETES, V55, P1484, DOI 10.2337/db05-1360
   CASPARY WF, 1977, DIABETOLOGIA, V13, P187, DOI 10.1007/BF01219698
   Catry E, 2018, GUT, V67, P271, DOI 10.1136/gutjnl-2016-313316
   Chandalia M, 2000, NEW ENGL J MED, V342, P1392, DOI 10.1056/NEJM200005113421903
   Chung WSF, 2017, FEMS MICROBIOL ECOL, V93, DOI 10.1093/femsec/fix127
   Dai FJ, 2017, J FOOD DRUG ANAL, V25, P37, DOI 10.1016/j.jfda.2016.09.006
   Dao MC, 2016, GUT, V65, P426, DOI 10.1136/gutjnl-2014-308778
   David LA, 2014, NATURE, V505, P559, DOI 10.1038/nature12820
   Davis HC, 2018, IRISH J MED SCI, V187, P393, DOI 10.1007/s11845-017-1686-9
   Davison KM, 2018, J DIABETES COMPLICAT, V32, P240, DOI 10.1016/j.jdiacomp.2017.11.002
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   De Vadder F, 2016, CELL METAB, V24, P151, DOI 10.1016/j.cmet.2016.06.013
   De Vadder F, 2014, CELL, V156, P84, DOI 10.1016/j.cell.2013.12.016
   Desai MS, 2016, CELL, V167, P1339, DOI 10.1016/j.cell.2016.10.043
   Dewulf EM, 2013, GUT, V62, P1112, DOI 10.1136/gutjnl-2012-303304
   Earle KA, 2015, CELL HOST MICROBE, V18, P478, DOI 10.1016/j.chom.2015.09.002
   Ellekilde M, 2014, RES VET SCI, V96, P241, DOI 10.1016/j.rvsc.2014.01.007
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Flint HJ, 2012, GUT MICROBES, V3, P289, DOI 10.4161/gmic.19897
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Furet JP, 2010, DIABETES, V59, P3049, DOI 10.2337/db10-0253
   Giongo A, 2011, ISME J, V5, P82, DOI 10.1038/ismej.2010.92
   Gowd V, 2019, FOOD RES INT, V120, P523, DOI 10.1016/j.foodres.2018.11.001
   Gowd V, 2018, FOOD CHEM, V269, P618, DOI 10.1016/j.foodchem.2018.07.020
   Gowd V, 2017, TRENDS FOOD SCI TECH, V68, P1, DOI 10.1016/j.tifs.2017.07.015
   Gowd V, 2016, WORLD J DIABETES, V7, P67, DOI 10.4239/wjd.v7.i4.67
   Greer RL, 2016, NAT COMMUN, V7, DOI 10.1038/ncomms13329
   LeBlanc JG, 2013, CURR OPIN BIOTECH, V24, P160, DOI 10.1016/j.copbio.2012.08.005
   Hansen CHF, 2012, DIABETOLOGIA, V55, P2285, DOI 10.1007/s00125-012-2564-7
   Hartstra AV, 2015, DIABETES CARE, V38, P159, DOI 10.2337/dc14-0769
   Hashemi Z, 2017, NUTRIENTS, V9, DOI 10.3390/nu9111236
   Ho KS, 2012, WORLD J GASTROENTERO, V18, P4593, DOI 10.3748/wjg.v18.i33.4593
   Huang W, 2017, METABOLISM, V68, P20, DOI 10.1016/j.metabol.2016.11.006
   InterAct Consortium, 2015, DIABETOLOGIA, V58, P1394, DOI 10.1007/s00125-015-3585-9
   Islam KBMS, 2011, GASTROENTEROLOGY, V141, P1773, DOI 10.1053/j.gastro.2011.07.046
   Jocken JWE, 2018, FRONT ENDOCRINOL, V8, DOI 10.3389/fendo.2017.00372
   Johansson EV, 2013, NUTR J, V12, DOI 10.1186/1475-2891-12-46
   Johnston KL, 2010, DIABETIC MED, V27, P391, DOI 10.1111/j.1464-5491.2010.02923.x
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Karlsson FH, 2012, NAT COMMUN, V3, DOI 10.1038/ncomms2266
   Kieffer DA, 2016, ADV NUTR, V7, P1111, DOI 10.3945/an.116.013219
   Koh A, 2016, CELL, V165, P1332, DOI 10.1016/j.cell.2016.05.041
   Kovatcheva-Datchary P, 2015, CELL METAB, V22, P971, DOI 10.1016/j.cmet.2015.10.001
   Lahti L, 2013, PEERJ, V1, DOI 10.7717/peerj.32
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Lasram MM, 2014, TOXICOLOGY, V322, P1, DOI 10.1016/j.tox.2014.04.009
   Le KA, 2013, FRONT PHYSIOL, V3, DOI 10.3389/fphys.2012.00496
   Lecerf JM, 2012, BRIT J NUTR, V108, P1847, DOI 10.1017/S0007114511007252
   Leiva-Gea I, 2018, DIABETES CARE, V41, P2385, DOI 10.2337/dc18-0253
   Li X, 2017, FRONT IMMUNOL, V8, DOI 10.3389/fimmu.2017.01882
   Li X, 2017, BIOSCI MICROB FOOD H, V36, P135, DOI 10.12938/bmfh.17-010
   Lin HV, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0035240
   Macfarlane GT, 2008, J APPL MICROBIOL, V104, P305, DOI 10.1111/j.1365-2672.2007.03520.x
   Macfarlane S, 2003, P NUTR SOC, V62, P67, DOI 10.1079/PNS2002207
   Makki K, 2018, CELL HOST MICROBE, V23, P705, DOI 10.1016/j.chom.2018.05.012
   Mathers CD, 2006, PLOS MED, V3, DOI 10.1371/journal.pmed.0030442
   MCNEIL NI, 1984, AM J CLIN NUTR, V39, P338, DOI 10.1093/ajcn/39.2.338
   McNelis JC, 2015, DIABETES, V64, P3203, DOI 10.2337/db14-1938
   McRae MP, 2018, J CHIROPR MED, V17, P44, DOI 10.1016/j.jcm.2017.11.002
   Membrez M, 2008, FASEB J, V22, P2416, DOI 10.1096/fj.07-102723
   Meyer KA, 2000, AM J CLIN NUTR, V71, P921
   Montandon SA, 2017, GENES-BASEL, V8, DOI 10.3390/genes8100250
   Montonen J, 2003, AM J CLIN NUTR, V77, P622, DOI 10.1093/ajcn/77.3.622
   Morowitz MJ, 2017, CRIT CARE MED, V45, pE516, DOI [10.1097/ccm.0000000000002291, 10.1097/CCM.0000000000002291]
   Morrison DJ, 2006, BRIT J NUTR, V96, P570, DOI 10.1079/BJN20061853
   Murri M, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-46
   Naito E, 2011, J APPL MICROBIOL, V110, P650, DOI 10.1111/j.1365-2672.2010.04922.x
   Napolitano A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100778
   Neyrinck AM, 2012, NUTR DIABETES, V2, DOI 10.1038/nutd.2011.24
   Neyrinck AM, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0020944
   Nilsson AC, 2010, J NUTR, V140, P1932, DOI 10.3945/jn.110.123604
   O'Hara AM, 2006, EMBO REP, V7, P688, DOI 10.1038/sj.embor.7400731
   Parnell JA, 2012, LIVER INT, V32, P701, DOI 10.1111/j.1478-3231.2011.02730.x
   Parnell JA, 2009, AM J CLIN NUTR, V89, P1751, DOI 10.3945/ajcn.2009.27465
   Priyadarshini M, 2015, MOL ENDOCRINOL, V29, P1055, DOI 10.1210/me.2015-1007
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Quercia S, 2017, DIABETES-METAB RES, V33, DOI 10.1002/dmrr.2927
   Ridlon JM, 2016, GUT MICROBES, V7, P22, DOI 10.1080/19490976.2015.1127483
   Roberfroid M, 2007, J NUTR, V137, p830S, DOI 10.1093/jn/137.3.830S
   Roberfroid M, 2010, BRIT J NUTR, V104, pS1, DOI 10.1017/S0007114510003363
   Russell WR, 2016, CRIT REV FOOD SCI, V56, P541, DOI 10.1080/10408398.2013.792772
   Salmeron J, 1997, JAMA-J AM MED ASSOC, V277, P472, DOI 10.1001/jama.277.6.472
   Salmeron J, 1997, DIABETES CARE, V20, P545, DOI 10.2337/diacare.20.4.545
   Santacruz A, 2009, OBESITY, V17, P1906, DOI 10.1038/oby.2009.112
   Sato J, 2014, DIABETES CARE, V37, P2343, DOI 10.2337/dc13-2817
   Scarpello JHB, 1998, DIABETIC MED, V15, P651, DOI 10.1002/(SICI)1096-9136(199808)15:8<651::AID-DIA628>3.0.CO;2-A
   Schaap FG, 2014, NAT REV GASTRO HEPAT, V11, P55, DOI 10.1038/nrgastro.2013.151
   Schroeder BO, 2018, CELL HOST MICROBE, V23, P27, DOI 10.1016/j.chom.2017.11.004
   Schulze MB, 2004, AM J CLIN NUTR, V80, P348, DOI 10.1093/ajcn/80.2.348
   Sender R, 2016, CELL, V164, P337, DOI 10.1016/j.cell.2016.01.013
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Soare A, 2014, NUTR METAB, V11, DOI 10.1186/1743-7075-11-39
   Sokol H, 2008, P NATL ACAD SCI USA, V105, P16731, DOI 10.1073/pnas.0804812105
   Sonnenburg ED, 2014, CELL METAB, V20, P779, DOI 10.1016/j.cmet.2014.07.003
   Steven J, 2002, DIABETES CARE, V25, P1715, DOI 10.2337/diacare.25.10.1715
   Tailford LE, 2015, FRONT GENET, V6, DOI 10.3389/fgene.2015.00081
   Tang C, 2015, NAT MED, V21, P173, DOI 10.1038/nm.3779
   Tolhurst G, 2012, DIABETES, V61, P364, DOI 10.2337/db11-1019
   Veprik A, 2016, FASEB J, V30, P3860, DOI 10.1096/fj.201500030R
   Vrieze A, 2014, J HEPATOL, V60, P824, DOI 10.1016/j.jhep.2013.11.034
   Vrieze A, 2012, GASTROENTEROLOGY, V143, P913, DOI 10.1053/j.gastro.2012.06.031
   Vulevic J, 2013, J NUTR, V143, P324, DOI 10.3945/jn.112.166132
   Wahlstrom A, 2016, CELL METAB, V24, P41, DOI 10.1016/j.cmet.2016.05.005
   Wang HY, 2018, BIOCHEM BIOPH RES CO, V498, P146, DOI 10.1016/j.bbrc.2018.02.017
   Weickert MO, 2008, J NUTR, V138, P439, DOI 10.1093/jn/138.3.439
   Weickert MO, 2018, J NUTR, V148, P7, DOI 10.1093/jn/nxx008
   Wong JMW, 2006, J CLIN GASTROENTEROL, V40, P235, DOI 10.1097/00004836-200603000-00015
   Wu GD, 2016, GUT, V65, P63, DOI 10.1136/gutjnl-2014-308209
   Wu GD, 2011, SCIENCE, V334, P105, DOI 10.1126/science.1208344
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Wu T, 2014, INT J FOOD SCI NUTR, V65, P351, DOI 10.3109/09637486.2013.854749
   Wu T, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0077585
   Wu XK, 2010, CURR MICROBIOL, V61, P69, DOI 10.1007/s00284-010-9582-9
   Xie LH, 2018, TRENDS FOOD SCI TECH, V72, P13, DOI 10.1016/j.tifs.2017.12.002
   Xu Y, 2019, CHEM COMMUN, V55, P39, DOI 10.1039/c8cc07985d
   Zeuthen LH, 2006, CLIN VACCINE IMMUNOL, V13, P365, DOI 10.1128/CVI.13.3.365-375.2006
   Zhang XY, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0071108
   Zhao LP, 2018, SCIENCE, V359, P1151, DOI 10.1126/science.aao5774
   Zhao LP, 2013, NAT REV MICROBIOL, V11, P639, DOI 10.1038/nrmicro3089
   Zheng JL, 2018, J AGR FOOD CHEM, V66, P5821, DOI [10.1021/acsjafc.8b00829, 10.1021/acs.jafc.8b00829]
   Zhou J, 2008, AM J PHYSIOL-ENDOC M, V295, pE1160, DOI 10.1152/ajpendo.90637.2008
   Zou J, 2018, CELL HOST MICROBE, V23, P41, DOI 10.1016/j.chom.2017.11.003
NR 139
TC 29
Z9 29
U1 7
U2 88
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0738-8551
EI 1549-7801
J9 CRIT REV BIOTECHNOL
JI Crit. Rev. Biotechnol.
PD MAY 19
PY 2019
VL 39
IS 4
BP 524
EP 540
DI 10.1080/07388551.2019.1576025
PG 17
WC Biotechnology & Applied Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology
GA HY7VL
UT WOS:000468344700006
PM 30810398
DA 2023-06-08
ER

PT J
AU Wang, YF
   Li, JW
   Wang, DP
   Jin, K
   Hui, JJ
   Xu, HY
AF Wang, Yi-Feng
   Li, Jia-Wei
   Wang, Da-Peng
   Jin, Ke
   Hui, Jiao-Jie
   Xu, Hong-Yang
TI Anti-Hyperglycemic Agents in the Adjuvant Treatment of Sepsis: Improving
   Intestinal Barrier Function
SO DRUG DESIGN DEVELOPMENT AND THERAPY
LA English
DT Review
DE sepsis; sepsis-induced organ dysfunction; intestinal barrier;
   anti-hyperglycemic agents
ID ACUTE LUNG INJURY; ACTIVATED RECEPTOR-GAMMA; NF-KAPPA-B;
   MULTIPLE-ORGAN-DYSFUNCTION; GUT MICROBIOTA; OXIDATIVE STRESS; CARDIAC
   DYSFUNCTION; METFORMIN PROTECTS; CURCUMIN PROTECTS; SIGNALING PATHWAY
AB Intestinal barrier injury and hyperglycemia are common in patients with sepsis. Bacteria translocation and systemic inflammatory response caused by intestinal barrier injury play a significant role in sepsis occurrence and deterioration, while hyperglycemia is linked to adverse outcomes in sepsis. Previous studies have shown that hyperglycemia is an independent risk factor for intestinal barrier injury. Concurrently, increasing evidence has indicated that some anti-hyperglycemic agents not only improve intestinal barrier function but are also beneficial in managing sepsis-induced organ dysfunction. Therefore, we assume that these agents can block or reduce the severity of sepsis by improving intestinal barrier function. Accordingly, we explicated the connection between sepsis, intestinal barrier, and hyperglycemia, overviewed the evidence on improving intestinal barrier function and alleviating sepsisinduced organ dysfunction by anti-hyperglycemic agents (eg, metformin, peroxisome proliferators activated receptor-?? agonists, berberine, and curcumin), and summarized some common characteristics of these agents to provide a new perspective in the adjuvant treatment of sepsis.
C1 [Wang, Yi-Feng; Li, Jia-Wei; Wang, Da-Peng; Jin, Ke; Hui, Jiao-Jie; Xu, Hong-Yang] Nanjing Med Univ, Wuxi Peoples Hosp, Dept Crit Care Med, Wuxi, Jiangsu, Peoples R China.
C3 Jiangnan University; Nanjing Medical University
RP Hui, JJ; Xu, HY (通讯作者)，Nanjing Med Univ, Wuxi Peoples Hosp, Dept Crit Care Med, Wuxi, Jiangsu, Peoples R China.
EM huijiaojie15@163.com; xhy1912@aliyun.com
RI li, jiawei/HOA-5023-2023; Li, Jiawei/GXM-4151-2022; Wang,
   Dapeng/HGD-4818-2022; 王, 逸峰/HDO-2385-2022; Li, Jiaxi/HTS-3430-2023
OI 王, 逸峰/0000-0002-1815-3991; Li, Jiaxi/0000-0002-8197-8590
FU National Natural Science Foundation of China [81401619]; Youth Medical
   Talent Project from Jiangsu Provincial Commission of Health and Family
   Planning [QNRC2016178]; Taihu-Talent Project of Wuxi government
FX This work was supported by the National Natural Science Foundation of
   China (81401619) , the Youth Medical Talent Project from Jiangsu
   Provincial Commission of Health and Family Planning (QNRC2016178) , and
   Taihu-Talent Project of Wuxi government.
CR Abraham E, 2016, JAMA-J AM MED ASSOC, V315, P757, DOI 10.1001/jama.2016.0290
   Abu-Ashour W, 2017, BMJ OPEN DIAB RES CA, V5, DOI 10.1136/bmjdrc-2016-000336
   Aggarwal BB, 2009, INT J BIOCHEM CELL B, V41, P40, DOI 10.1016/j.biocel.2008.06.010
   Aktas E, 2020, J TRADIT CHIN MED, V40, P820, DOI 10.19852/j.cnki.jtcm.2020.05.012
   Ange M, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-93156-1
   Anhe FF, 2021, CELL REP, V36, DOI 10.1016/j.celrep.2021.109691
   Araujo CV, 2012, MICROVASC RES, V84, P218, DOI 10.1016/j.mvr.2012.05.006
   Araujo CV, 2016, SHOCK, V45, P393, DOI 10.1097/SHK.0000000000000520
   Arnone D, 2022, CLIN GASTROENTEROL H, V20, P1912, DOI 10.1016/j.cgh.2021.12.011
   Assimakopoulos SF, 2018, INFECTION, V46, P751, DOI 10.1007/s15010-018-1178-5
   Bal F, 2014, DIABETES RES CLIN PR, V106, P295, DOI 10.1016/j.diabres.2014.08.028
   Bergheim I, 2006, J PHARMACOL EXP THER, V316, P1053, DOI 10.1124/jpet.105.092122
   Bone NB, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-90573-0
   Brunkhorst FM, 2008, NEW ENGL J MED, V358, P125, DOI 10.1056/NEJMoa070716
   Bu Yanan, 2015, Zhonghua Yi Xue Za Zhi, V95, P3180
   Burge K, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20081912
   Cao ST, 2020, FREE RADICAL BIO MED, V147, P8, DOI 10.1016/j.freeradbiomed.2019.12.004
   Carey IM, 2018, DIABETES CARE, V41, P513, DOI 10.2337/dc17-2131
   Chen HQ, 2021, PHARM BIOL, V59, P121, DOI 10.1080/13880209.2021.1877736
   Chen LW, 2018, INT IMMUNOPHARMACOL, V61, P1, DOI 10.1016/j.intimp.2018.04.041
   Chen YX, 2021, DRUG DES DEV THER, V15, P4849, DOI 10.2147/DDDT.S334325
   Chen YT, 2020, MATER EXPRESS, V10, P337, DOI 10.1166/mex.2020.1642
   Costantini E, 2021, ACTA DIABETOL, V58, P1139, DOI 10.1007/s00592-021-01728-4
   Dempe JS, 2013, MOL NUTR FOOD RES, V57, P1543, DOI 10.1002/mnfr.201200113
   Deng J, 2016, Zhonghua Yi Xue Za Zhi, V96, P2311, DOI 10.3760/cma.j.issn.0376-2491.2016.29.006
   Deng J, 2018, J CELL MOL MED, V22, P546, DOI 10.1111/jcmm.13342
   Di Tommaso N, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph182312836
   Drosatos K, 2013, CIRC-HEART FAIL, V6, P550, DOI 10.1161/CIRCHEARTFAILURE.112.000177
   Dugo L, 2006, CRIT CARE MED, V34, P1489, DOI 10.1097/01.CCM.0000215457.83953.E3
   Fajas L, 1997, J BIOL CHEM, V272, P18779, DOI 10.1074/jbc.272.30.18779
   Fang M, 2021, DIABETOLOGIA, V64, P2458, DOI 10.1007/s00125-021-05522-3
   Feng AW, 2012, INT IMMUNOPHARMACOL, V12, P182, DOI 10.1016/j.intimp.2011.11.009
   Feng XC, 2021, FRONT PHARMACOL, V11, DOI 10.3389/fphar.2020.594852
   Fink MP, 2004, CRIT CARE MED, V32, P604, DOI 10.1097/01.CCM.0000110667.86935.F3
   Gao M, 2015, J SURG RES, V195, P550, DOI 10.1016/j.jss.2015.02.007
   Ghosh SS, 2018, TISSUE BARRIERS, V6, DOI 10.1080/21688370.2018.1425085
   Gong J, 2017, FRONT PHARMACOL, V8, DOI 10.3389/fphar.2017.00042
   Gu LL, 2011, J INFECT DIS, V203, P1602, DOI 10.1093/infdis/jir147
   Hassan FI, 2020, CELL J, V22, P29, DOI 10.22074/cellj.2020.7046
   Hassan FI, 2020, CELL J, V21, P363, DOI 10.22074/cellj.2020.6286
   Haussner F, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.00891
   He Dan, 2021, Zhonghua Wei Zhong Bing Ji Jiu Yi Xue, V33, P1052, DOI 10.3760/cma.j.cn121430-20210105-00008
   He Y, 2018, CELL PHYSIOL BIOCHEM, V49, P1342, DOI 10.1159/000493412
   He Y, 2018, FITOTERAPIA, V124, P200, DOI 10.1016/j.fitote.2017.11.012
   Hotchkiss RS, 2016, NAT REV DIS PRIMERS, V2, DOI 10.1038/nrdp.2016.45
   Hou QK, 2019, BIOMED PHARMACOTHER, V118, DOI 10.1016/j.biopha.2019.109206
   Howell MD, 2017, JAMA-J AM MED ASSOC, V317, P847, DOI 10.1001/jama.2017.0131
   Hsieh MS, 2021, EMERG MED INT, V2021, DOI 10.1155/2021/4916777
   Huang JZ, 2021, BIOENGINEERED, V12, P11947, DOI 10.1080/21655979.2021.2009322
   Huang W, 2020, LIFE SCI, V254, DOI 10.1016/j.lfs.2020.117340
   Huang YL, 2020, INFLAMMATION, V43, P568, DOI 10.1007/s10753-019-01138-3
   Isaac S, 2017, J ANTIMICROB CHEMOTH, V72, P128, DOI 10.1093/jac/dkw383
   Jia YF, 2020, REDOX BIOL, V32, DOI 10.1016/j.redox.2020.101534
   Jin K, 2020, FASEB J, V34, P7036, DOI 10.1096/fj.201901900R
   Jing WH, 2021, PHARMACOL RES, V164, DOI 10.1016/j.phrs.2020.105358
   Kaplan J, 2014, INNATE IMMUN-LONDON, V20, P519, DOI 10.1177/1753425913501565
   Kaplan JM, 2018, INTENS CARE MED, V44, P2006, DOI 10.1007/s00134-018-5374-7
   Karimi A, 2019, PHYTOTHER RES, V33, P2798, DOI 10.1002/ptr.6467
   Ke HR, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.726707
   Kim E, 2021, CTS-CLIN TRANSL SCI, V14, P1955, DOI 10.1111/cts.13051
   Kingir ZB, 2019, ULUS TRAVMA ACIL CER, V25, P213, DOI 10.5505/tjtes.2018.82826
   Klingensmith NJ, 2016, CRIT CARE CLIN, V32, P203, DOI 10.1016/j.ccc.2015.11.004
   Kumari A, 2015, INFLAMMATION, V38, P1103, DOI 10.1007/s10753-014-0076-y
   Kutsukake M, 2014, J SURG RES, V189, P295, DOI 10.1016/j.jss.2014.03.007
   Lan JR, 2015, J ETHNOPHARMACOL, V161, P69, DOI 10.1016/j.jep.2014.09.049
   Lee S, 2005, NEPHROL DIAL TRANSPL, V20, P1057, DOI 10.1093/ndt/gfh705
   Li DH, 2017, PHARMACOGN MAG, V13, P677, DOI 10.4103/pm.pm_584_16
   Li GX, 2015, KOREAN J PHYSIOL PHA, V19, P1, DOI 10.4196/kjpp.2015.19.1.1
   Li H, 2020, ACTA PHARMACOL SIN B, V10, P447, DOI 10.1016/j.apsb.2019.08.006
   Li HM, 2011, ACTA PHARMACOL SIN, V32, P1364, DOI 10.1038/aps.2011.102
   Li MH, 2019, DOSE-RESPONSE, V17, DOI 10.1177/1559325819827436
   Li YN, 2020, LIFE SCI, V261, DOI 10.1016/j.lfs.2020.118460
   Li Y, 2019, NEUROGASTROENT MOTIL, V31, DOI 10.1111/nmo.13556
   Liang HY, 2014, MOL MED REP, V9, P1827, DOI 10.3892/mmr.2014.1996
   Liang HY, 2019, CRIT CARE, V23, DOI 10.1186/s13054-019-2346-4
   Liang YP, 2019, ENDOCR J, V66, P51, DOI 10.1507/endocrj.EJ18-0109
   Liu G, 2017, INT IMMUNOPHARMACOL, V47, P166, DOI 10.1016/j.intimp.2017.04.002
   Liu ZY, 2015, MOL MED, V21, P937, DOI 10.2119/molmed.2015.00198
   Lopresti AL, 2018, ADV NUTR, V9, P41, DOI 10.1093/advances/nmx011
   Lu W, 2015, EXP THER MED, V9, P377, DOI 10.3892/etm.2014.2105
   Lv Y, 2017, J PHARMACEUT BIOMED, V145, P794, DOI 10.1016/j.jpba.2017.07.062
   Maayah ZH, 2021, INFLAMMOPHARMACOLOGY, V29, P269, DOI 10.1007/s10787-020-00732-4
   Malik F, 2018, DIABETES-METAB RES, V34, DOI 10.1002/dmrr.2975
   Manfredini A, 2019, CLIN SCI, V133, P1993, DOI 10.1042/CS20190351
   Marik PE, 2004, INTENS CARE MED, V30, P748, DOI 10.1007/s00134-004-2167-y
   McCreight LJ, 2016, DIABETOLOGIA, V59, P426, DOI 10.1007/s00125-015-3844-9
   Mittal R, 2014, TRENDS MOL MED, V20, P214, DOI 10.1016/j.molmed.2013.08.004
   Nanjan MJ, 2018, BIOORG CHEM, V77, P548, DOI 10.1016/j.bioorg.2018.02.009
   Nelson KM, 2017, J MED CHEM, V60, P1620, DOI 10.1021/acs.jmedchem.6b00975
   Niu LY, 2011, FITOTERAPIA, V82, P323, DOI 10.1016/j.fitote.2010.11.007
   Niu YY, 2021, INT IMMUNOPHARMACOL, V96, DOI 10.1016/j.intimp.2021.107773
   Nozu T, 2021, BIOMED PHARMACOTHER, V139, DOI 10.1016/j.biopha.2021.111649
   Odenwald MA, 2017, NAT REV GASTRO HEPAT, V14, P9, DOI 10.1038/nrgastro.2016.169
   Olivier S, 2021, MOL METAB, V47, DOI 10.1016/j.molmet.2021.101183
   Onizawa M, 2015, NAT IMMUNOL, V16, P618, DOI 10.1038/ni.3172
   Osinski C, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23073732
   Peng SY, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/8326749
   Pierpaoli E, 2021, NAT PROD RES, V35, P4779, DOI 10.1080/14786419.2020.1721729
   Pivari F, 2019, NUTRIENTS, V11, DOI 10.3390/nu11081837
   Rao S, 2011, SCAND J INFECT DIS, V43, P386, DOI 10.3109/00365548.2010.544671
   Regnier M, 2021, J ENDOCRINOL, V248, pR67, DOI 10.1530/JOE-20-0473
   Rhodes A, 2017, CRIT CARE MED, V45, P486, DOI 10.1097/CCM.0000000000002255
   Rudd KE, 2020, LANCET, V395, P200, DOI 10.1016/S0140-6736(19)32989-7
   Shan CY, 2013, J ENDOCRINOL, V218, P255, DOI 10.1530/JOE-13-0184
   Shen Chuan-an, 2006, Zhongguo Wei Zhong Bing Ji Jiu Yi Xue, V18, P139
   Shi Bin, 2009, Zhongguo Wei Zhong Bing Ji Jiu Yi Xue, V21, P492
   Shi J, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.760186
   Shih CJ, 2015, SCI REP-UK, V5, DOI 10.1038/srep15260
   Siddiqui AM, 2006, CRIT CARE MED, V34, P1874, DOI 10.1097/01.CCM.0000221921.71300.BF
   Singh S, 2021, EUR J MED CHEM, V226, DOI 10.1016/j.ejmech.2021.113839
   Song DY, 2020, FRONT MED-PRC, V14, P564, DOI 10.1007/s11684-019-0724-6
   SUM CF, 1992, DIABETIC MED, V9, P61, DOI 10.1111/j.1464-5491.1992.tb01716.x
   Tan Kaiquan, 2019, Crit Care Explor, V1, pe0009, DOI 10.1097/CCE.0000000000000009
   Tang GM, 2017, ONCOTARGET, V8, P97977, DOI 10.18632/oncotarget.20105
   Thaiss CA, 2018, SCIENCE, V359, P1376, DOI 10.1126/science.aar3318
   Tian SY, 2016, KOREAN J PHYSIOL PHA, V20, P147, DOI 10.4196/kjpp.2016.20.2.147
   Tzanavari T, 2016, METABOLISM, V65, P1447, DOI 10.1016/j.metabol.2016.06.012
   Vachharajani V, 2010, MICROCIRCULATION, V17, P407, DOI 10.1111/j.1549-8719.2010.00039.x
   Vaez H, 2016, IRAN J ALLERGY ASTHM, V15, P498
   Vaez H, 2016, INT IMMUNOPHARMACOL, V40, P501, DOI 10.1016/j.intimp.2016.10.002
   Wang CY, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.01873
   Wang GZ, 2014, EUR J PHARMACOL, V726, P27, DOI 10.1016/j.ejphar.2014.01.030
   Wang N, 2012, DIGEST DIS SCI, V57, P1792, DOI 10.1007/s10620-012-2094-7
   Wang S, 2021, DRUG DES DEV THER, V15, P4243, DOI 10.2147/DDDT.S332623
   Wang YY, 2011, SHOCK, V35, P322, DOI 10.1097/SHK.0b013e3181facf73
   Wang YF, 2021, PEERJ, V9, DOI 10.7717/peerj.10800
   Wang Y, 2020, PATHOG DIS, V78, DOI 10.1093/femspd/ftaa047
   Wu WC, 2018, MOL PHARMACEUT, V15, P3272, DOI 10.1021/acs.molpharmaceut.8b00332
   Xiao XF, 2012, J SURG RES, V176, pE31, DOI 10.1016/j.jss.2011.11.1032
   Xiong XY, 2021, BIOMED PHARMACOTHER, V134, DOI 10.1016/j.biopha.2020.111129
   Xu F, 2013, INT IMMUNOPHARMACOL, V16, P1, DOI 10.1016/j.intimp.2013.03.014
   Yang C, 2013, PHARM BIOL, V51, P482, DOI 10.3109/13880209.2012.742116
   Yang FX, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.706908
   Yang QL, 2021, FRONT MED, V8, P8
   Yin Haiyan, 2017, Zhonghua Wei Zhong Bing Ji Jiu Yi Xue, V29, P162, DOI 10.3760/cma.j.issn.2095-4352.2017.02.013
   Yu C, 2016, BIOL PHARM BULL, V39, P1787, DOI 10.1248/bpb.b16-00280
   Yu CB, 2020, FISH SHELLFISH IMMUN, V102, P336, DOI 10.1016/j.fsi.2020.04.052
   Zaghloul MS, 2022, ENVIRON TOXICOL PHAR, V91, DOI 10.1016/j.etap.2022.103833
   Zhang BX, 2022, FRONT CELL INFECT MI, V12, DOI 10.3389/fcimb.2022.855075
   Zhang DL, 2021, J ETHNOPHARMACOL, V264, DOI 10.1016/j.jep.2020.113206
   Zhang HQ, 2008, SHOCK, V29, P617, DOI 10.1097/SHK.0b013e318157ea14
   Zhang LC, 2017, EXP THER MED, V13, P3374, DOI 10.3892/etm.2017.4402
   Zhang MM, 2020, DOSE-RESPONSE, V18, DOI 10.1177/1559325820938543
   Zhang Q, 2020, DIABET METAB SYND OB, V13, P5003, DOI 10.2147/DMSO.S286430
   Zhang SM, 2020, EUR REV MED PHARMACO, V24, P452, DOI 10.26355/eurrev_202001_19945
   Zhang XC, 2017, SAUDI PHARM J, V25, P666, DOI 10.1016/j.jsps.2017.05.001
   Zhang XT, 2021, ACTA PHARM SIN B, V11, P1789, DOI 10.1016/j.apsb.2020.09.013
   Zhang YF, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-18414-8
   Zhao JF, 2018, DIGEST LIVER DIS, V50, P1195, DOI 10.1016/j.dld.2018.04.016
   Zhao ML, 2016, INT J CLIN EXP MED, V9, P6107
   Zheng YA, 2021, J CHROMATOGR B, V1164, DOI 10.1016/j.jchromb.2021.122525
   Zhong WH, 2016, BIOMED PHARMACOTHER, V83, P302, DOI 10.1016/j.biopha.2016.06.036
   Zhou XX, 2021, GASTROENT RES PRACT, V2021, DOI 10.1155/2021/5570796
   Zhu H, 2017, EUR REV MED PHARMACO, V21, P5239, DOI 10.26355/eurrev_201711_13847
   Zhu HK, 2020, CELL CYCLE, V19, P1941, DOI 10.1080/15384101.2020.1784599
   Zingarelli B, 2005, SHOCK, V23, P393, DOI 10.1097/01.shk.0000160521.91363.88
   Zohar Y, 2021, INTERN EMERG MED, V16, P719, DOI 10.1007/s11739-020-02507-9
   Zong X, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.01674
NR 158
TC 3
Z9 3
U1 9
U2 20
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1177-8881
J9 DRUG DES DEV THER
JI Drug Des. Dev. Ther.
PY 2022
VL 16
BP 1697
EP 1711
DI 10.2147/DDDT.S360348
PG 15
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 2A1KO
UT WOS:000809269300003
PM 35693534
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Singh, S
   Karagas, MR
   Mueller, NT
AF Singh, Sirtaj
   Karagas, Margaret R.
   Mueller, Noel T.
TI Charting the Maternal and Infant Microbiome: What Is the Role of
   Diabetes and Obesity in Pregnancy?
SO CURRENT DIABETES REPORTS
LA English
DT Review
DE Gestational diabetes; Pregnancy; Diabetes; Obesity; Gestational weight
   gain; Microbiome
ID GUT MICROBIOTA; VAGINAL MICROBIOME; AKKERMANSIA-MUCINIPHILA; BARRIER
   FUNCTION; BIRTH-WEIGHT; ASSOCIATION; WOMEN; PREVALENCE; METFORMIN;
   MELLITUS
AB Purpose of Review The purpose of this review is to summarize the evidence on whether diabetes, obesity, and related metabolic derangements during pregnancy are associated with the maternal and infant microbiomes, and to identify gaps in the literature and offer guidance on future research on this topic.
   Recent Findings We found circumstantial evidence from four observational studies that the maternal gut microbiome was associated with either pre-pregnancy body mass index, gestational weight gain, gestational diabetes, and/or related metabolic biomarkers in pregnancy; we did not identify any studies that examined whether the vaginal microbiome varied according to these metabolic parameters. Maternal diabetes (in one study) and pregnancy weight status (in three studies) were found to be associated with the infant offspring gut microbiome, although some associations only appeared in certain cohort strata. Patterns of association across both maternal and infant microbiome studies, however, lacked consistency, which may owe to biologic or technical differences, or to the lack of control for important confounders or effect modifiers (e.g., delivery mode in infant microbiome studies).
   Summary Metabolic diseases in pregnancy, such as diabetes and obesity, may be associated with the maternal and infant microbiomes, but there is a need for large prospective studies of mother-child dyads from diverse racial and ethnic backgrounds to determine the direction and potential causal nature of these associations. These studies should include serially collected biospecimens, standardized workflows that conserve microbial DNA and RNA, and rich data on clinical outcomes and environmental, lifestyle, and genetic risk factors for obesity and diabetes.
C1 [Singh, Sirtaj; Mueller, Noel T.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, 615 North Wolfe St, Baltimore, MD 21205 USA.
   [Karagas, Margaret R.] Geisel Sch Med Dartmouth, Dept Epidemiol, One Med Ctr Dr 7927,Rubin Bldg, Lebanon, NH 03756 USA.
   [Mueller, Noel T.] Johns Hopkins Univ, Welch Ctr Prevent Epidemiol & Clin Res, Baltimore, MD USA.
C3 Johns Hopkins University; Johns Hopkins Bloomberg School of Public
   Health; Dartmouth College; Johns Hopkins University
RP Mueller, NT (通讯作者)，Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, 615 North Wolfe St, Baltimore, MD 21205 USA.; Mueller, NT (通讯作者)，Johns Hopkins Univ, Welch Ctr Prevent Epidemiol & Clin Res, Baltimore, MD USA.
EM ssingh59@jhu.edu; Margaret.R.Karagas@Dartmouth.edu; noeltmueller@jhu.edu
OI Mueller, Noel/0000-0002-7412-8352
CR Aagaard K, 2014, SCI TRANSL MED, V6, DOI 10.1126/scitranslmed.3008599
   Amarasekara R, 2015, J OBSTET GYNAECOL RE, V41, P662, DOI 10.1111/jog.12619
   Anna V, 2008, DIABETES CARE, V31, P2288, DOI 10.2337/dc08-1038
   Antony KM, 2015, AM J OBSTET GYNECOL, V212, DOI 10.1016/j.ajog.2014.12.041
   Backhed F, 2004, P NATL ACAD SCI USA, V101, P15718, DOI 10.1073/pnas.0407076101
   Backhed F, 2015, CELL HOST MICROBE, V17, P690, DOI [10.1016/j.chom.2015.04.004, 10.1016/j.chom.2015.05.012]
   Bassols J, 2016, PEDIATR RES, V80, P777, DOI 10.1038/pr.2016.155
   Bisanz JE, 2015, APPL ENVIRON MICROB, V81, P4965, DOI 10.1128/AEM.00780-15
   Bokulich NA, 2016, SCI TRANSL MED, V8, DOI 10.1126/scitranslmed.aad7121
   Boney CM, 2005, PEDIATRICS, V115, pE290, DOI 10.1542/peds.2004-1808
   Cani PD, 2007, DIABETOLOGIA, V50, P2374, DOI 10.1007/s00125-007-0791-0
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   Collado MC, 2010, AM J CLIN NUTR, V92, P1023, DOI 10.3945/ajcn.2010.29877
   Collado MC, 2008, AM J CLIN NUTR, V88, P894, DOI 10.1093/ajcn/88.4.894
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   DeSisto CL, 2014, PREV CHRONIC DIS, V11, DOI 10.5888/pcd11.130415
   Di Cesare M, 2016, LANCET, V387, P1377, DOI 10.1016/S0140-6736(16)30054-X
   DiGiulio DB, 2015, P NATL ACAD SCI USA, V112, P11060, DOI 10.1073/pnas.1502875112
   Everard A, 2014, REV ENDOCR METAB DIS, V15, P189, DOI 10.1007/s11154-014-9288-6
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Fadl H, 2014, BJOG-INT J OBSTET GY, V121, P1530, DOI 10.1111/1471-0528.12754
   Fasano A, 2011, PHYSIOL REV, V91, P151, DOI 10.1152/physrev.00003.2008
   Ferrara A, 2007, DIABETES CARE, V30, pS141, DOI 10.2337/dc07-s206
   Fettweis JM, 2014, MICROBIOL-SGM, V160, P2272, DOI 10.1099/mic.0.081034-0
   Finucane MM, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0084689
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Fugmann M, 2015, SCI REP-UK, V5, DOI 10.1038/srep13212
   Galley JD, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0113026
   Cano PG, 2013, OBESITY, V21, P2310, DOI 10.1002/oby.20330
   GIRDWOOD R H, 1955, Rev Hematol, V10, P187
   Girdwood RH, 1955, REV HEMATOL, V10, P207
   Gomez-Arango LF, 2016, DIABETES, V65, P2214, DOI 10.2337/db16-0278
   Hu JZ, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0078257
   Human Microbiome Project Consortium, 2012, Nature, V486, P207, DOI 10.1038/nature11234
   Ignell C, 2014, ACTA OBSTET GYN SCAN, V93, P420, DOI 10.1111/aogs.12340
   Jayashree B, 2014, MOL CELL BIOCHEM, V388, P203, DOI 10.1007/s11010-013-1911-4
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kau AL, 2011, NATURE, V474, P327, DOI 10.1038/nature10213
   Kerr CA, 2015, CRIT REV MICROBIOL, V41, P326, DOI 10.3109/1040841X.2013.837863
   Koren O, 2012, CELL, V150, P470, DOI 10.1016/j.cell.2012.07.008
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Lauder AP, 2016, MICROBIOME, V4, DOI 10.1186/s40168-016-0172-3
   Lawlor DA, 2011, CIRCULATION, V123, P258, DOI 10.1161/CIRCULATIONAHA.110.980169
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Ley RE, 2005, P NATL ACAD SCI USA, V102, P11070, DOI 10.1073/pnas.0504978102
   Lin HP, 2012, PLOS ONE, V7, DOI [10.1371/journal.pone.0031286, 10.1371/journal.pone.0035240]
   Ma J, 2014, NAT COMMUN, V5, DOI 10.1038/ncomms4889
   MacDonald PE, 2002, DIABETES, V51, pS434, DOI 10.2337/diabetes.51.2007.S434
   MacIntyre DA, 2015, SCI REP-UK, V5, DOI 10.1038/srep08988
   Madan JC, 2016, JAMA PEDIATR, V170, P212, DOI 10.1001/jamapediatrics.2015.3732
   Moreno-Navarrete JM, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0037160
   Millar MR, 2017, BJOG-INT J OBSTET GY, V124, P70, DOI 10.1111/1471-0528.14234
   Mokkala K, 2016, J NUTR, V146, P1694, DOI 10.3945/jn.116.235358
   Mueller NT, 2016, SCI REP-UK, V6, DOI 10.1038/srep23133
   Mueller NT, 2015, TRENDS MOL MED, V21, P109, DOI 10.1016/j.molmed.2014.12.002
   Natarajan N, 2014, AM J PHYSIOL-CELL PH, V307, pC979, DOI 10.1152/ajpcell.00228.2014
   O'Hanlon DE, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0080074
   Page KA, 2014, J PEDIATR-US, V164, P807, DOI 10.1016/j.jpeds.2013.11.063
   Patel S, 2016, BMC PEDIATR, V16, DOI 10.1186/s12887-016-0585-y
   Ploger S, 2012, ANN NY ACAD SCI, V1258, P52, DOI 10.1111/j.1749-6632.2012.06553.x
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Qin JJ, 2010, NATURE, V464, P59, DOI 10.1038/nature08821
   Reid G, 2008, J CLIN GASTROENTEROL, V42, pS234, DOI 10.1097/MCG.0b013e31817f1298
   Romero R, 2014, MICROBIOME, V2, DOI 10.1186/2049-2618-2-18
   Romero R, 2014, MICROBIOME, V2, DOI 10.1186/2049-2618-2-4
   Santacruz A, 2010, BRIT J NUTR, V104, P83, DOI 10.1017/S0007114510000176
   Sears C, 2015, CAN J DIABETES, V39, P443, DOI 10.1016/j.jcjd.2015.09.007
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Tolhurst G, 2012, DIABETES, V61, P364, DOI 10.2337/db11-1019
   Vohr BR, 1999, DIABETES CARE, V22, P1284, DOI 10.2337/diacare.22.8.1284
   Xiang AH, 2015, JAMA-J AM MED ASSOC, V313, P1425, DOI 10.1001/jama.2015.2707
   Zak-Golab A, 2013, INT J ENDOCRINOL, V2013, DOI 10.1155/2013/674106
   Zhang X, 2015, SCI REP-UK, V5, DOI 10.1038/srep14405
   Zheng J, 2015, NUTRIENTS, V7, P6924, DOI 10.3390/nu7085315
   Zhou ZY, 2016, ACTA PHARMACOL SIN, V37, P1063, DOI 10.1038/aps.2016.21
   Zhu YY, 2016, CURR DIABETES REP, V16, DOI 10.1007/s11892-015-0699-x
NR 76
TC 22
Z9 30
U1 0
U2 17
PU CURRENT MEDICINE GROUP
PI PHILADELPHIA
PA 400 MARKET STREET, STE 700, PHILADELPHIA, PA 19106 USA
SN 1534-4827
EI 1539-0829
J9 CURR DIABETES REP
JI Curr. Diabetes Rep.
PD FEB
PY 2017
VL 17
IS 2
AR 11
DI 10.1007/s11892-017-0836-9
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EO7KE
UT WOS:000396868800005
PM 28176229
OA Green Accepted
DA 2023-06-08
ER

PT J
AU Tian, R
   Liu, HH
   Feng, SQ
   Wang, H
   Wang, YF
   Wang, YY
   Liang, LF
   Xu, HP
   Xing, HP
   Zhang, SY
AF Tian, Ran
   Liu, Honghong
   Feng, Siqin
   Wang, Hui
   Wang, Yifei
   Wang, Yiyang
   Liang, Lifeng
   Xu, Haopeng
   Xing, Haiping
   Zhang, Shuyang
TI Gut microbiota dysbiosis in stable coronary artery disease combined with
   type 2 diabetes mellitus influences cardiovascular prognosis
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Article
DE Stable coronary artery disease; Type 2 diabetes mellitus; Metagenomics;
   Metabolomics; Multi-omics analysis; Cardiovascular prognosis
ID INSULIN ACTION; GLUCOSE; BIOMARKERS; PROFILES; OUTCOMES; PLASMA
AB Background and aims: Host-microbiota interactions involving metabolic pathways have been linked to the pathogenesis of atherosclerotic disease and type 2 diabetes. As stable coronary artery disease (SCAD) patients combined with type 2 diabetes have significantly increased risk for cardiac event, we focused on elucidating the role of microbiota affecting cardiometabolic disease development.
   Methods and results: We used multi-omics analyses (metagenomics and metabolomics) of fecal and serum samples from a prospective cohort including stable coronary artery disease combined with diabetes mellitus (SCAD + T2DM, n = 38), SCAD (n = 71), and healthy control (HC, n = 55). We linked microbiome features to disease severity in a three-pronged association analysis and identified prognostic bacterial biomarkers. We identified that bacterial and metabolic signatures varied significantly between SCAD and SCAD + T2DM groups. SCAD + T2DM individuals were characterized by increased levels of aromatic amino acids and carbohydrates, which correlate with a gut microbiome with enriched biosynthetic potential. Our study also addressed how metformin may confound gut dysbiosis and increase the potential for nitrogen metabolism. In addition, we found that specific bacterial taxa Ruminococcus torques [HR: 2.363 (08-4.56), P = 0.03] was predictive of cardiac survival outcomes.
   Conclusion: Overall, our study identified relationships between features of the gut microbiota (GM) and circulating metabolites, providing a new direction for future studies aiming to understand the host-GM interplay in atherosclerotic cardiovascular pathogenesis.
C1 [Tian, Ran; Liu, Honghong; Feng, Siqin; Wang, Hui; Wang, Yifei; Wang, Yiyang; Xu, Haopeng; Xing, Haiping; Zhang, Shuyang] Peking Union Med Coll & Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Cardiol, Beijing, Peoples R China.
   [Wang, Yifei; Wang, Yiyang] Tsinghua Univ, Dept Med, Beijing, Peoples R China.
   [Liang, Lifeng] Sun Yat Sen Univ, Affiliated Hosp 1, Precis Med Inst, Guangzhou 510080, Guangdong, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College; Peking Union Medical College Hospital;
   Tsinghua University; Sun Yat Sen University
RP Zhang, SY (通讯作者)，Peking Union Med Coll & Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Cardiol, Beijing, Peoples R China.
EM ron_tian@163.com; liuhonghong0625@163.com; fengsiqinv@163.com;
   huiwang097@163.co; yifei-wang13@mails.tsinghua.edu.cn;
   wang-yy14@mails.tsinghua.edu.cn; lianglifeng0101@163.com;
   xhpeng2011@sina.com; xinghaip@163.com; shuyangzhang103@nrdrs.org
OI Wang, Yifei/0000-0002-3313-0974; feng, siqin/0000-0003-0823-2175; Liang,
   Lifeng/0000-0002-1904-1158
FU National Natural Science Foundation of China [81670329]; CAMS Innovation
   Fund for Medical Sciences (CIFMS) [2016-I2M-1-011, 2017-I2M-2-001,
   2016-I2M-3-011]
FX This work was supported by the National Natural Science Foundation of
   China (81670329) and CAMS Innovation Fund for Medical Sciences (CIFMS)
   (No. 2016-I2M-1-011, 2017-I2M-2-001, 2016-I2M-3-011).
CR Adam J, 2016, DIABETES, V65, P3776, DOI 10.2337/db16-0512
   Andreasen AS, 2010, BRIT J NUTR, V104, P1831, DOI 10.1017/S0007114510002874
   Ascher S, 2018, EUR J IMMUNOL, V48, P564, DOI 10.1002/eji.201646879
   Brahe LK, 2015, NUTR DIABETES, V5, DOI 10.1038/nutd.2015.9
   Bulugahapitiya U, 2009, DIABETIC MED, V26, P142, DOI 10.1111/j.1464-5491.2008.02640.x
   Burcelin R, 2011, ACTA DIABETOL, V48, P257, DOI 10.1007/s00592-011-0333-6
   Cefalu WT, 2019, DIABETES CARE, V42, pS103, DOI 10.2337/dc19S010
   Chen YX, 2017, GIGASCIENCE, V7, DOI 10.1093/gigascience/gix120
   Cheng ML, 2015, J AM COLL CARDIOL, V65, P1509, DOI 10.1016/j.jacc.2015.02.018
   Gaike AH, 2020, MSYSTEMS, V5, DOI 10.1128/mSystems.00578-19
   GENSINI GG, 1983, AM J CARDIOL, V51, P606, DOI 10.1016/S0002-9149(83)80105-2
   Gosset G, 2009, CURR OPIN BIOTECH, V20, P651, DOI 10.1016/j.copbio.2009.09.012
   Gurung M, 2020, EBIOMEDICINE, V51, DOI 10.1016/j.ebiom.2019.11.051
   Howard BV, 2006, DIABETES CARE, V29, P391, DOI 10.2337/diacare.29.02.06.dc05-1299
   Huffman KM, 2009, DIABETES CARE, V32, P1678, DOI 10.2337/dc08-2075
   Kaysen GA, 2015, J RENAL NUTR, V25, P351, DOI 10.1053/j.jrn.2015.02.006
   Kelly TN, 2016, CIRC RES, V119, P956, DOI 10.1161/CIRCRESAHA.116.309219
   Kiouptsi K, 2019, MBIO, V10, DOI 10.1128/mBio.02298-19
   Kurilshikov A, 2019, CIRC RES, V124, P1808, DOI 10.1161/CIRCRESAHA.118.314642
   La Reau AJ, 2016, MICROB GENOMICS, V2, DOI 10.1099/mgen.0.000099
   Lever M, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0114969
   Li J, 2017, MICROBIOME, V5, DOI 10.1186/s40168-016-0222-x
   Li JH, 2014, NAT BIOTECHNOL, V32, P834, DOI 10.1038/nbt.2942
   Li RQ, 2008, BIOINFORMATICS, V24, P713, DOI 10.1093/bioinformatics/btn025
   Li YJ, 2014, J CHROMATOGR B, V966, P147, DOI 10.1016/j.jchromb.2014.04.047
   Libby P, 2017, J AM COLL CARDIOL, V70, P2278, DOI 10.1016/j.jacc.2017.09.028
   Liu HH, 2020, J TRANSL MED, V18, DOI 10.1186/s12967-020-02539-x
   Liu HH, 2019, MICROBIOME, V7, DOI 10.1186/s40168-019-0683-9
   Lu JY, 2012, J PROTEOME RES, V11, P4705, DOI 10.1021/pr300523x
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Mayneris-Perxachs J, 2020, FEBS J, V287, P856, DOI 10.1111/febs.15130
   Mazloom Z, 2013, IRAN J MED SCI, V38, P38
   Menni C, 2020, GUT MICROBES, V11, P1632, DOI 10.1080/19490976.2020.1778261
   Menni C, 2013, DIABETES, V62, P4270, DOI 10.2337/db13-0570
   Messana I, 1998, CLIN CHEM, V44, P1529
   Murphy R, 2017, OBES SURG, V27, P917, DOI 10.1007/s11695-016-2399-2
   Paun A, 2017, J IMMUNOL, V198, P590, DOI 10.4049/jimmunol.1601519
   Pedersen HK, 2016, NATURE, V535, P376, DOI 10.1038/nature18646
   Ridaura VK, 2013, SCIENCE, V341, P1079, DOI 10.1126/science.1241214
   Salek RM, 2007, PHYSIOL GENOMICS, V29, P99, DOI 10.1152/physiolgenomics.00194.2006
   Sanchez-Alcoholado L, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.01936
   Sasaki M, 2013, BMC GASTROENTEROL, V13, DOI 10.1186/1471-230X-13-81
   Wang ZN, 2011, NATURE, V472, P57, DOI 10.1038/nature09922
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Wu YX, 2020, ACTA DIABETOL, V57, P569, DOI 10.1007/s00592-019-01434-2
   Zhang XY, 2009, J PROTEOME RES, V8, P5188, DOI 10.1021/pr900524z
   Zhao LP, 2018, SCIENCE, V359, P1151, DOI 10.1126/science.aao5774
   Zuo K, 2020, BMC GENOMICS, V21, DOI 10.1186/s12864-020-06944-w
NR 48
TC 8
Z9 10
U1 2
U2 31
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0939-4753
EI 1590-3729
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD MAY 6
PY 2021
VL 31
IS 5
BP 1454
EP 1466
DI 10.1016/j.numecd.2021.01.007
EA APR 2021
PG 13
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA RQ5DP
UT WOS:000642438300014
PM 33810955
DA 2023-06-08
ER

PT J
AU Bakir-Gungor, B
   Bulut, O
   Jabeer, A
   Nalbantoglu, OU
   Yousef, M
AF Bakir-Gungor, Burcu
   Bulut, Osman
   Jabeer, Amhar
   Nalbantoglu, O. Ufuk
   Yousef, Malik
TI Discovering Potential Taxonomic Biomarkers of Type 2 Diabetes From Human
   Gut Microbiota via Different Feature Selection Methods
SO FRONTIERS IN MICROBIOLOGY
LA English
DT Article
DE feature selection; metagenomic analysis; classification; machine
   learning; type 2 diabetes; human gut microbiome
ID INTESTINAL MICROBIOTA; BARIATRIC SURGERY; INSULIN SENSITIVITY;
   OBESE-PATIENTS; GLUCOSE; INDIVIDUALS; METFORMIN; BIOTIN; DIET; RISK
AB Human gut microbiota is a complex community of organisms including trillions of bacteria. While these microorganisms are considered as essential regulators of our immune system, some of them can cause several diseases. In recent years, next-generation sequencing technologies accelerated the discovery of human gut microbiota. In this respect, the use of machine learning techniques became popular to analyze disease-associated metagenomics datasets. Type 2 diabetes (T2D) is a chronic disease and affects millions of people around the world. Since the early diagnosis in T2D is important for effective treatment, there is an utmost need to develop a classification technique that can accelerate T2D diagnosis. In this study, using T2D-associated metagenomics data, we aim to develop a classification model to facilitate T2D diagnosis and to discover T2D-associated biomarkers. The sequencing data of T2D patients and healthy individuals were taken from a metagenome-wide association study and categorized into disease states. The sequencing reads were assigned to taxa, and the identified species are used to train and test our model. To deal with the high dimensionality of features, we applied robust feature selection algorithms such as Conditional Mutual Information Maximization, Maximum Relevance and Minimum Redundancy, Correlation Based Feature Selection, and select K best approach. To test the performance of the classification based on the features that are selected by different methods, we used random forest classifier with 100-fold Monte Carlo cross-validation. In our experiments, we observed that 15 commonly selected features have a considerable effect in terms of minimizing the microbiota used for the diagnosis of T2D and thus reducing the time and cost. When we perform biological validation of these identified species, we found that some of them are known as related to T2D development mechanisms and we identified additional species as potential biomarkers. Additionally, we attempted to find the subgroups of T2D patients using k-means clustering. In summary, this study utilizes several supervised and unsupervised machine learning algorithms to increase the diagnostic accuracy of T2D, investigates potential biomarkers of T2D, and finds out which subset of microbiota is more informative than other taxa by applying state-of-the art feature selection methods.</p>
C1 [Bakir-Gungor, Burcu; Bulut, Osman; Jabeer, Amhar] Abdullah Gul Univ, Fac Engn, Dept Comp Engn, Kayseri, Turkey.
   [Nalbantoglu, O. Ufuk] Erciyes Univ, Dept Comp Engn, Genome & Stem Cell Ctr, Kayseri, Turkey.
   [Yousef, Malik] Zefat Acad Coll, Dept Informat Syst, Safed, Israel.
   [Yousef, Malik] Zefat Acad Coll, Galilee Digital Hlth Res Ctr, Safed, Israel.
C3 Abdullah Gul University; Erciyes University; Erciyes University
RP Bakir-Gungor, B (通讯作者)，Abdullah Gul Univ, Fac Engn, Dept Comp Engn, Kayseri, Turkey.
EM burcu.gungor@agu.edu.tr
RI Nalbantoglu, Ufuk/AAA-8033-2022
FU Abdullah Gul University Support Foundation (AGUV); Zefat Academic
   College
FX The work of BB-G has been supported by the Abdullah Gul University
   Support Foundation (AGUV). The work of MY has been supported by the
   Zefat Academic College. The funders had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript.
CR Albarracini CA, 2008, DIABETES-METAB RES, V24, P41, DOI 10.1002/dmrr.755
   Allin KH, 2018, DIABETOLOGIA, V61, P810, DOI 10.1007/s00125-018-4550-1
   [Anonymous], 2019, IDF DIABETES ATLAS
   Aoki R, 2017, SCI REP-UK, V7, DOI 10.1038/srep43522
   Aw W, 2018, J DIABETES INVEST, V9, P5, DOI 10.1111/jdi.12673
   Berthold MR, 2008, STUD CLASS DATA ANAL, P319, DOI 10.1145/1656274.1656280
   Boulange CL, 2016, GENOME MED, V8, DOI 10.1186/s13073-016-0303-2
   Breyner NM, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.00114
   Brown G, 2012, J MACH LEARN RES, V13, P27
   Brunetti P, 2007, INT J CLIN PRACT, V61, P3, DOI 10.1111/j.1742-1241.2007.01359.x
   Centers for Disease Control and Prevention, 2020, NAT DIAB STAT REP
   Chang YC, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0180025
   Chobot A, 2018, DIABETES-METAB RES, V34, DOI 10.1002/dmrr.3042
   Dagdeviren S, 2017, FASEB J, V31, P701, DOI 10.1096/fj.201600832R
   Daousi C, 2006, POSTGRAD MED J, V82, P280, DOI 10.1136/pmj.2005.039032
   Diabetes.co.uk, 2019, GLOB DIAB COMM DIAB
   Doumatey AP, 2020, FRONT CELL INFECT MI, V10, DOI 10.3389/fcimb.2020.00063
   Duvallet C, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-01973-8
   Falony G, 2016, SCIENCE, V352, P560, DOI 10.1126/science.aad3503
   Fernandez-Mejia C, 2005, J NUTR BIOCHEM, V16, P424, DOI 10.1016/j.jnutbio.2005.03.018
   Fleuret F, 2004, J MACH LEARN RES, V5, P1531
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Furet JP, 2010, DIABETES, V59, P3049, DOI 10.2337/db10-0253
   Gao RY, 2018, OBESITY, V26, P351, DOI 10.1002/oby.22088
   Cano PG, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0041079
   Graessler J, 2013, PHARMACOGENOMICS J, V13, P514, DOI 10.1038/tpj.2012.43
   Gurung M, 2020, EBIOMEDICINE, V51, DOI 10.1016/j.ebiom.2019.11.051
   Hacilar H., 2019, ARXIV PREPRINT ARXIV
   He Y, 2018, NAT MED, V24, P1532, DOI 10.1038/s41591-018-0164-x
   Hoffmann TW, 2016, ISME J, V10, P460, DOI 10.1038/ismej.2015.127
   Huttenhower C, 2012, NATURE, V486, P207, DOI 10.1038/nature11234
   International Diabetes Federation, 2003, DIABETES ATLAS, V2nd
   James W., 2003, COMP QUANTIFICATION
   Kameyama K, 2014, MICROBES ENVIRON, V29, P427, DOI 10.1264/jsme2.ME14054
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kikuchi K, 2018, BIOCHEM BIOPH RES CO, V501, P1041, DOI 10.1016/j.bbrc.2018.05.105
   Kostic AD, 2015, CELL HOST MICROBE, V17, P260, DOI 10.1016/j.chom.2015.01.001
   Kuang Z, 2019, SCIENCE, V365, P1428, DOI 10.1126/science.aaw3134
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   de la Vega-Monroy MLL, 2013, J NUTR BIOCHEM, V24, P169, DOI 10.1016/j.jnutbio.2012.03.020
   Le KA, 2013, FRONT PHYSIOL, V3, DOI 10.3389/fphys.2012.00496
   Liang X, 2015, P NATL ACAD SCI USA, V112, P10479, DOI 10.1073/pnas.1501305112
   MAEBASHI M, 1993, J CLIN BIOCHEM NUTR, V14, P211
   Makki K, 2018, CELL HOST MICROBE, V23, P705, DOI 10.1016/j.chom.2018.05.012
   Manor O, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-18871-1
   Marcos-Zambrano LJ, 2021, FRONT MICROBIOL, V12, DOI 10.3389/fmicb.2021.634511
   Mardinoglu A, 2016, CELL METAB, V23, P10, DOI 10.1016/j.cmet.2015.12.012
   Mendes-Soares H, 2019, JAMA NETW OPEN, V2, DOI 10.1001/jamanetworkopen.2018.8102
   Moya-Perez A, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0126976
   Murphy R, 2017, OBES SURG, V27, P917, DOI 10.1007/s11695-016-2399-2
   Narayan KMV, 2007, DIABETES CARE, V30, P1562, DOI 10.2337/dc06-2544
   National Diabetes Clearinghouse, 2011, NAT DIAB STAT 2011
   Pasolli E, 2016, PLOS COMPUT BIOL, V12, DOI 10.1371/journal.pcbi.1004977
   Patrone V, 2016, FRONT MICROBIOL, V7, DOI 10.3389/fmicb.2016.00200
   Pedregosa Fabian, 2011, J MACH LEARN RES, V12s, P2825
   Peters BA, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-28126-1
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Qin JJ, 2010, NATURE, V464, P59, DOI 10.1038/nature08821
   Quevrain E, 2016, GUT, V65, P415, DOI 10.1136/gutjnl-2014-307649
   Reitmeier S, 2020, CELL HOST MICROBE, V28, P258, DOI 10.1016/j.chom.2020.06.004
   Remely M, 2014, GENE, V537, P85, DOI 10.1016/j.gene.2013.11.081
   Rossi O, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0123013
   Salamon D, 2018, POL ARCH INTERN MED, V128, P336, DOI 10.20452/pamw.4246
   Sanna S, 2019, NAT GENET, V51, P600, DOI 10.1038/s41588-019-0350-x
   Senliol B, 2008, 23RD INTERNATIONAL SYMPOSIUM ON COMPUTER AND INFORMATION SCIENCES, P500
   Sharma S, 2019, J NUTR BIOCHEM, V63, P101, DOI 10.1016/j.jnutbio.2018.10.003
   Sokol H, 2008, P NATL ACAD SCI USA, V105, P16731, DOI 10.1073/pnas.0804812105
   Steinley D, 2007, J CLASSIF, V24, P99, DOI 10.1007/s00357-007-0003-0
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Tabak AG, 2012, LANCET, V379, P2279, DOI 10.1016/S0140-6736(12)60283-9
   Thaiss CA, 2014, CELL, V159, P514, DOI 10.1016/j.cell.2014.09.048
   Le TKC, 2015, BIOMED RES-TOKYO, V36, P63, DOI 10.2220/biomedres.36.63
   Thingholm LB, 2019, CELL HOST MICROBE, V26, P252, DOI 10.1016/j.chom.2019.07.004
   Tibshirani R, 1996, J ROY STAT SOC B MET, V58, P267, DOI 10.1111/j.2517-6161.1996.tb02080.x
   Tong XL, 2018, MBIO, V9, DOI 10.1128/mBio.02392-17
   Troseid M, 2013, DIABETES CARE, V36, P3627, DOI 10.2337/dc13-0451
   Turnbaugh PJ, 2009, NATURE, V457, P480, DOI 10.1038/nature07540
   Vacca M, 2020, MICROORGANISMS, V8, DOI 10.3390/microorganisms8040573
   Valdes AM, 2018, BMJ-BRIT MED J, V361, DOI 10.1136/bmj.k2179
   Vrieze A, 2012, GASTROENTEROLOGY, V143, P913, DOI 10.1053/j.gastro.2012.06.031
   Wang JJ, 2015, ISME J, V9, P1, DOI 10.1038/ismej.2014.99
   Wang K, 2019, CELL REP, V26, P222, DOI 10.1016/j.celrep.2018.12.028
   Wu H, 2020, CELL METAB, V32, P379, DOI 10.1016/j.cmet.2020.06.011
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Wu XK, 2010, CURR MICROBIOL, V61, P69, DOI 10.1007/s00284-010-9582-9
   Xu QS, 2001, CHEMOMETR INTELL LAB, V56, P1, DOI 10.1016/S0169-7439(00)00122-2
   Yang JY, 2017, MUCOSAL IMMUNOL, V10, P104, DOI 10.1038/mi.2016.42
   Yoshida N, 2018, CIRCULATION, V138, P2486, DOI 10.1161/CIRCULATIONAHA.118.033714
   Zeevi D, 2015, CELL, V163, P1079, DOI 10.1016/j.cell.2015.11.001
   Zhang CH, 2010, ISME J, V4, P232, DOI 10.1038/ismej.2009.112
   Zhang XY, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0071108
   Zhernakova A, 2016, SCIENCE, V352, P565, DOI 10.1126/science.aad3369
   Zhong HZ, 2019, EBIOMEDICINE, V47, P373, DOI 10.1016/j.ebiom.2019.08.048
   Zhou WY, 2019, NATURE, V569, P663, DOI 10.1038/s41586-019-1236-x
   Zou H, 2005, J R STAT SOC B, V67, P301, DOI 10.1111/j.1467-9868.2005.00503.x
NR 95
TC 6
Z9 6
U1 1
U2 13
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1664-302X
J9 FRONT MICROBIOL
JI Front. Microbiol.
PD AUG 25
PY 2021
VL 12
AR 628426
DI 10.3389/fmicb.2021.628426
PG 16
WC Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology
GA UU4XN
UT WOS:000698805300001
PM 34512559
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Bay, V
   Gur, S
   Bayraktar, O
AF Bay, Veysel
   Gur, Seray
   Bayraktar, Oguz
TI Plant-derived tormentic acid alters the gut microbiota of the silkworm
   (Bombyx mori)
SO SCIENTIFIC REPORTS
LA English
DT Article
ID METFORMIN; PERFORMANCE; METABOLITE; COMPONENT
AB In recent years, phytochemicals have started to attract more attention due to their contribution to health and bioactivity. Microorganisms in the intestines of organisms contribute to the processing, function, and biotransformation of these substances. The silkworm (Bombyx mori) is one of the organisms used for the biotransformation of phytochemicals due to its controlled reproduction and liability to microbial manipulation. In this study, a bioactive compound, tormentic acid (TA), extracted from Sarcopoterium spinosum was used in the silkworm diet, and the alterations of intestinal microbiota of the silkworm were assessed. To do this, silkworms were fed on a diet with various tormentic acid content, and 16S metagenomic analysis was performed to determine the alterations in the gut microbiota profile of these organisms. Diet with different TA content did not cause a change in the bacterial diversity of the samples. A more detailed comparison between different feeding groups indicated increased abundance of bacteria associated with health, i.e., Intestinibacter spp., Flavonifractor spp., Senegalimassilia spp., through the utilization of bioactive substances such as flavonoids. In conclusion, it might be said that using TA as a supplementary product might help ameliorate the infected gut, promote the healthy gut, and relieve the undesirable effects of medicines on the gastrointestinal system.
C1 [Bay, Veysel] Ege Univ, Fac Agr, Dept Anim Sci, TR-35100 Izmir, Turkey.
   [Gur, Seray; Bayraktar, Oguz] Ege Univ, Fac Engn, Dept Bioengn, TR-35100 Izmir, Turkey.
C3 Ege University; Ege University
RP Bay, V (通讯作者)，Ege Univ, Fac Agr, Dept Anim Sci, TR-35100 Izmir, Turkey.
EM veysel.bay@ege.edu.tr
RI Bay, Veysel/AAD-6135-2019; Bayraktar, Oguz/Q-9265-2019
OI Bay, Veysel/0000-0002-9339-4840; Bayraktar, Oguz/0000-0003-4210-2825
CR Adamberg K, 2018, ANAEROBE, V52, P100, DOI 10.1016/j.anaerobe.2018.06.009
   Asano N, 2001, J AGR FOOD CHEM, V49, P4208, DOI 10.1021/jf010567e
   Bay V, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-33993-9
   Bryrup T, 2019, DIABETOLOGIA, V62, P1024, DOI 10.1007/s00125-019-4848-7
   Cabreiro F, 2016, CELL HOST MICROBE, V19, P1, DOI 10.1016/j.chom.2015.12.012
   Callahan BJ, 2016, NAT METHODS, V13, P581, DOI [10.1038/NMETH.3869, 10.1038/nmeth.3869]
   Caporaso JG, 2010, NAT METHODS, V7, P335, DOI 10.1038/nmeth.f.303
   Chen BS, 2020, ENVIRON INT, V143, DOI 10.1016/j.envint.2020.105886
   Chen BS, 2018, ISME J, V12, P2252, DOI 10.1038/s41396-018-0174-1
   Chen XW, 2021, FRONT VET SCI, V8, DOI 10.3389/fvets.2021.589624
   Chi X, 2018, BIORESOURCE TECHNOL, V263, P562, DOI 10.1016/j.biortech.2018.04.120
   de Sousa IP, 2018, MOLECULES, V23, DOI 10.3390/molecules23061387
   Demain AL, 2008, MOL BIOTECHNOL, V38, P41, DOI 10.1007/s12033-007-0035-z
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Garcia-Beltran C, 2021, PEDIATR OBES, V16, DOI 10.1111/ijpo.12734
   Gomathi D, 2012, J BIOMED RES, V26, P295, DOI 10.7555/JBR.26.20110128
   Gupta A, 2019, MSYSTEMS, V4, DOI 10.1128/mSystems.00438-19
   Hameed ASS, 2020, BIOTECHNOL ADV, V43, DOI 10.1016/j.biotechadv.2020.107576
   Harrison JF, 2001, ANNU REV ENTOMOL, V46, P221, DOI 10.1146/annurev.ento.46.1.221
   He BB, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19082407
   Hirayama C, 2008, PHYTOCHEMISTRY, V69, P1141, DOI 10.1016/j.phytochem.2007.11.009
   Hosseini E, 2011, NUTR REV, V69, P245, DOI 10.1111/j.1753-4887.2011.00388.x
   Jian CX, 2015, ARCH ORAL BIOL, V60, P1327, DOI 10.1016/j.archoralbio.2015.05.005
   Kebamo S., 2015, J DRUG METAB TOXICOL, V06, DOI [DOI 10.4172/2157-7609.1000196, 10.4172/2157-7609.1000196]
   Koponen KK, 2021, AM J CLIN NUTR, V114, P605, DOI 10.1093/ajcn/nqab077
   Kumar D., 2020, NATURAL MAT PRODUCTS, DOI [10.1007/978-3-030-36610-0, DOI 10.1007/978-3-030-36610-0_6]
   Lee Y, 2021, DIABETES RES CLIN PR, V178, DOI 10.1016/j.diabres.2021.108985
   Leyva-Lopez N, 2020, FOODS, V9, DOI 10.3390/foods9070843
   Li C, 2021, ACTA BIOCH BIOPH SIN, V53, P1342, DOI 10.1093/abbs/gmab116
   Li GN, 2022, SCI TOTAL ENVIRON, V838, DOI 10.1016/j.scitotenv.2022.156220
   Li GN, 2022, ENVIRON MICROBIOL, V24, P4049, DOI 10.1111/1462-2920.15934
   Li QR, 2019, CAN J MICROBIOL, V65, P45, DOI 10.1139/cjm-2018-0350
   Li ZP, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.00004
   Liang XL, 2018, APPL MICROBIOL BIOT, V102, P4951, DOI 10.1007/s00253-018-8953-1
   Lin X, 2014, INT IMMUNOPHARMACOL, V19, P365, DOI 10.1016/j.intimp.2014.02.009
   Liu J, 2019, J HAZARD MATER, V376, P29, DOI 10.1016/j.jhazmat.2019.05.014
   Liu XH, 2013, CHEM RES CHINESE U, V29, P526, DOI 10.1007/s40242-013-2366-6
   Metsalu T, 2015, NUCLEIC ACIDS RES, V43, pW566, DOI 10.1093/nar/gkv468
   Mikami A, 2021, FRONT NUTR, V7, DOI 10.3389/fnut.2020.610946
   Mismisuraya MA, 2015, J ENG SCI TECHNOL, V10, P14
   Moran NA, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0036393
   Muhammad A, 2022, SCI TOTAL ENVIRON, V813, DOI 10.1016/j.scitotenv.2021.152608
   Peng YJ, 2020, FOOD RES INT, V130, DOI 10.1016/j.foodres.2019.108952
   Ponzo V, 2019, NUTRIENTS, V11, DOI 10.3390/nu11020330
   Pryor R, 2015, BIOCHEM J, V471, P307, DOI 10.1042/BJ20150497
   Rohela GK, 2020, TREES FOREST PEOPLE, V2, DOI 10.1016/j.tfp.2020.100011
   Shakya A.K., 2016, INT J HERB MED, V4, P59
   Ulbrich K, 2015, FOOD RES INT, V67, P349, DOI 10.1016/j.foodres.2014.11.051
   Upadhyaya S., 2013, J PHARM RES, V7, P139, DOI DOI 10.1016/j.jopr.2013.01.015
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Wu JB, 2014, J AGR FOOD CHEM, V62, P10717, DOI 10.1021/jf503334d
   Yeruva T, 2020, PROBIOTICS ANTIMICRO, V12, P635, DOI 10.1007/s12602-019-09580-3
   Zhang N, 2021, COMPUT STRUCT BIOTEC, V19, P4658, DOI 10.1016/j.csbj.2021.08.020
   Zheng W, 2015, MICROBIOME, V3, DOI 10.1186/s40168-015-0110-9
   Zikmanis P, 2020, WORLD J MICROB BIOT, V36, DOI 10.1007/s11274-020-02937-9
NR 55
TC 0
Z9 0
U1 5
U2 8
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JUL 29
PY 2022
VL 12
IS 1
AR 13005
DI 10.1038/s41598-022-17478-4
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 3J3ZD
UT WOS:000833335700007
PM 35906393
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Hussein, HM
   Elyamany, MF
   Rashed, LA
   Sallam, NA
AF Hussein, Hebatallah M.
   Elyamany, Mohammed F.
   Rashed, Laila A.
   Sallam, Nada A.
TI Vitamin D mitigates diabetes-associated metabolic and cognitive
   dysfunction by modulating gut microbiota and colonic cannabinoid
   receptor 1
SO EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
LA English
DT Article
DE Vitamin D; Obesity; Diabetes; Gut microbiota; CB1R; Cognitive function
ID HIGH-FAT DIET; INDUCED OBESITY; INDUCED INFLAMMATION; D DEFICIENCY;
   RISK-FACTORS; MEMORY; RATS; IMPAIRMENT; OVERWEIGHT; SUSCEPTIBILITY
AB Introduction: Obesity is associated with elevated endocannabinoid tone, gut dysbiosis, and inflammation predisposing to diabetes. The endocannabinoid system mediates the effects of gut microbiota and regulates the gut barrier integrity. We examined the effects of vitamin D (VD) on colonic cannabinoid receptor 1(CB1R), tight junction proteins, gut dysbiosis, metabolic and cognitive dysfunction in a model of type 2 diabetes compared with metformin.
   Methods: Rats received high-fat, high-sucrose diet (HFSD) and either VD (500 IU/kg/day; p.o.), or metformin (200 mg/kg/day; p.o.) for 8 weeks. After 6 weeks, streptozotocin (STZ) (40 mg/kg; i.p) was injected. Behavioral, cognitive, and metabolic assessments were carried out. Finally, fecal, blood, and tissue samples were collected to examine Bacteroidetes/Firmicutes ratio, colonic CB1R, zonula occludens-1 (ZO-1), occludin, and Toll-like receptor 4 (TLR4); serum lipopolysaccharides (LPS), peptidoglycan (PGN), tumor necrosis factor-alpha (TNF-alpha), glucagon-like peptide-1 (GLP-1), lipids, and VD; hippocampal brain-derived neurotrophic factor (BDNF) and inflammatory markers.
   Results: VD ameliorated HFSD/STZ-induced dysbiosis/gut barrier dysfunction as indicated by lower circulating LPS, PGN and TNF-alpha levels, likely by downregulating colonic CB1R and upregulating ZO-1 and occludin expressions. Additionally, VD suppressed HFSD/STZ-induced hyperglycemia, hyperinsulinemia, dyslipidemia, and hippocampal neuroinflammation. These changes culminated in improved glycemic control and cognitive function. VD was more effective than metformin in decreasing serum LPS and TNF-alpha levels; whereas metformin resulted in better glycemic control.
   Conclusion: Targeting gut microbiota by VD could be a successful strategy in the treatment of diabetes and associated cognitive deficit. The crosstalk between VD axis and the endocannabinoid system needs further exploration.
C1 [Hussein, Hebatallah M.; Elyamany, Mohammed F.; Sallam, Nada A.] Cairo Univ, Fac Pharm, Dept Pharmacol & Toxicol, Kasr Al Aini St, Cairo 11562, Egypt.
   [Rashed, Laila A.] Cairo Univ, Fac Med, Dept Biochem & Mol Biol, Cairo, Egypt.
C3 Egyptian Knowledge Bank (EKB); Cairo University; Egyptian Knowledge Bank
   (EKB); Cairo University
RP Sallam, NA (通讯作者)，Cairo Univ, Fac Pharm, Dept Pharmacol & Toxicol, Kasr Al Aini St, Cairo 11562, Egypt.
EM nada.sallam@pharma.cu.edu.eg
CR Abd El-Haleim EA, 2022, FUND CLIN PHARMACOL, V36, P338, DOI 10.1111/fcp.12720
   Rojas LBA, 2013, DIABETOL METAB SYNDR, V5, DOI 10.1186/1758-5996-5-6
   Ahren B, 2004, HORM METAB RES, V36, P867, DOI 10.1055/s-2004-826178
   Alkharfy KM, 2013, CARDIOVASC DIABETOL, V12, DOI 10.1186/1475-2840-12-113
   Chagas CEA, 2012, NUTRIENTS, V4, P52, DOI 10.3390/nu4010052
   [Anonymous], EUR J PHARM SCI, V170
   Babberich EDT, 2015, CURR ALZHEIMER RES, V12, P173
   Barriere DA, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-017-18896-5
   Bekinschtein P, 2008, NEUROSCIENTIST, V14, P147, DOI 10.1177/1073858407305850
   Bercik P, 2010, GASTROENTEROLOGY, V139, P2102, DOI 10.1053/j.gastro.2010.06.063
   Boitard C, 2014, BRAIN BEHAV IMMUN, V40, P9, DOI 10.1016/j.bbi.2014.03.005
   Bowe JE, 2014, J ENDOCRINOL, V222, pG13, DOI 10.1530/JOE-14-0182
   Bruce-Keller AJ, 2015, BIOL PSYCHIAT, V77, P607, DOI 10.1016/j.biopsych.2014.07.012
   Camer D, 2015, PROG NEURO-PSYCHOPH, V59, P68, DOI 10.1016/j.pnpbp.2015.01.004
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Cani PD, 2016, NAT REV ENDOCRINOL, V12, P133, DOI 10.1038/nrendo.2015.211
   Cantorna MT, 2014, EXP BIOL MED, V239, P1524, DOI 10.1177/1535370214523890
   Charoenngam N, 2020, ANTICANCER RES, V40, P551, DOI 10.21873/anticanres.13984
   Ciubotaru I, 2015, TRANSL RES, V166, P401, DOI 10.1016/j.trsl.2015.06.015
   COCCHETTO DM, 1983, J PHARM SCI-US, V72, P465, DOI 10.1002/jps.2600720503
   Maranduba CMD, 2015, J IMMUNOL RES, V2015, DOI 10.1155/2015/931574
   Davidson EP, 2011, EUR J PHARMACOL, V668, P497, DOI 10.1016/j.ejphar.2011.07.016
   Del Pinto R, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18112360
   Denou E, 2015, EMBO MOL MED, V7, P259, DOI 10.15252/emmm.201404169
   Despres JP, 2005, NEW ENGL J MED, V353, P2121, DOI 10.1056/NEJMoa044537
   Di Marzo V, 2019, NUTRIENTS, V11, DOI 10.3390/nu11081956
   Dinan TG, 2015, J PSYCHIATR RES, V63, P1, DOI 10.1016/j.jpsychires.2015.02.021
   Drincic AT, 2012, OBESITY, V20, P1444, DOI 10.1038/oby.2011.404
   Duca FA, 2013, J NUTR BIOCHEM, V24, P1663, DOI 10.1016/j.jnutbio.2013.05.005
   Enciso PLM, 2015, BIOCHEM BIOPH RES CO, V461, P165, DOI 10.1016/j.bbrc.2015.04.008
   ENNACEUR A, 1988, BEHAV BRAIN RES, V31, P47, DOI 10.1016/0166-4328(88)90157-X
   Etxeberria U, 2015, FOOD FUNCT, V6, P2758, DOI [10.1039/C5FO00473J, 10.1039/c5fo00473j]
   Fernandes de Abreu D.A., 2009, PSYCHONEUROENDOCRINO, P34
   Flory J, 2019, JAMA-J AM MED ASSOC, V321, P1926, DOI 10.1001/jama.2019.3805
   Forte N, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21051554
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   Fruhauf-Perez PK, 2018, NEUROBIOL LEARN MEM, V149, P135, DOI 10.1016/j.nlm.2018.02.012
   Grayson B, 2007, BEHAV BRAIN RES, V184, P31, DOI 10.1016/j.bbr.2007.06.012
   Grieco M, 2019, FRONT NEUROSCI-SWITZ, V13, DOI 10.3389/fnins.2019.01112
   Guida F, 2020, BRAIN BEHAV IMMUN, V85, P128, DOI 10.1016/j.bbi.2019.04.006
   Guilherme A, 2008, NAT REV MOL CELL BIO, V9, P367, DOI 10.1038/nrm2391
   Gulseth HL, 2013, CURR VASC PHARMACOL, V11, P968, DOI 10.2174/15701611113119990169
   Hajiluian G, 2017, INT J OBESITY, V41, P639, DOI 10.1038/ijo.2017.10
   Herrmann M, 2015, DIABETES CARE, V38, P521, DOI 10.2337/dc14-0180
   Holick MF, 2017, ADV EXP MED BIOL, V996, P137, DOI 10.1007/978-3-319-56017-5_12
   Huang XB, 2012, BRAIN RES, V1469, P82, DOI 10.1016/j.brainres.2012.06.011
   Kang C, 2017, MBIO, V8, DOI [10.1128/mBio.00470-17, 10.1128/mBio.00900-17, 10.1128/mbio.00470-17]
   Karkeni E, 2015, ENDOCRINOLOGY, V156, P1782, DOI 10.1210/en.2014-1647
   Kaur C, 2014, BRAIN STRUCT FUNCT, V219, P151, DOI 10.1007/s00429-012-0491-5
   Khetpal S, 2020, WATER AIR SOIL POLL, DOI [DOI 10.1007/S11270-007-9372-6, DOI 10.1007/s11270-007-9372-6]
   Kim CH, 2018, CELL MOL IMMUNOL, V15, P88, DOI 10.1038/cmi.2017.57
   Kim KA, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0047713
   Kong J, 2008, AM J PHYSIOL-GASTR L, V294, pG208, DOI 10.1152/ajpgi.00398.2007
   Koshkina A, 2019, NUTRIENTS, V11, DOI 10.3390/nu11081726
   Lacroix S, 2019, MSYSTEMS, V4, DOI 10.1128/mSystems.00407-19
   Lardner AL, 2015, FRONT MOL NEUROSCI, V8, DOI 10.3389/fnmol.2015.00058
   Latimer CS, 2014, P NATL ACAD SCI USA, V111, pE4359, DOI 10.1073/pnas.1404477111
   Lee JW, 2008, J NEUROINFLAMM, V5, DOI 10.1186/1742-2094-5-37
   Lee YS, 2016, MEDIAT INFLAMM, V2016, DOI 10.1155/2016/3094642
   Little TJ, 2018, AM J PHYSIOL-ENDOC M, V315, pE489, DOI 10.1152/ajpendo.00355.2017
   Littlejohns TJ, 2014, NEUROLOGY, V83, P920, DOI 10.1212/WNL.0000000000000755
   Liu TJ, 2016, SCI REP-UK, V6, DOI 10.1038/srep32889
   Luthold RV, 2017, METABOLISM, V69, P76, DOI 10.1016/j.metabol.2017.01.007
   Lv ZQ, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.00191
   Magnusson KR, 2015, NEUROSCIENCE, V300, P128, DOI 10.1016/j.neuroscience.2015.05.016
   Malaguarnera L, 2020, INT IMMUNOPHARMACOL, V79, DOI 10.1016/j.intimp.2019.106112
   Manca C, 2020, J LIPID RES, V61, P70, DOI 10.1194/jlr.RA119000424
   Marcotorchino J, 2014, J NUTR BIOCHEM, V25, P1077, DOI 10.1016/j.jnutbio.2014.05.010
   Mayne PE, 2019, TRENDS NEUROSCI, V42, P293, DOI 10.1016/j.tins.2019.01.003
   Mehrpouya-Bahrami P, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-15154-6
   Messa P, 2011, J NEPHROL, V24, pS30, DOI 10.5301/JN.2011.7767
   Misiak B, 2012, BRAIN RES BULL, V89, P144, DOI 10.1016/j.brainresbull.2012.08.003
   Moghadamnia AA, 2015, ARCH IRAN MED, V18, P362, DOI 015186/AIM.007
   MORRIS R, 1984, J NEUROSCI METH, V11, P47, DOI 10.1016/0165-0270(84)90007-4
   Mostafa DK, 2016, EUR J PHARMACOL, V792, P38, DOI 10.1016/j.ejphar.2016.10.031
   Muccioli GG, 2010, MOL SYST BIOL, V6, DOI 10.1038/msb.2010.46
   Mutt SJ, 2012, FASEB J, V26, P4400, DOI 10.1096/fj.12-210880
   Nair Anroop B, 2016, J Basic Clin Pharm, V7, P27, DOI 10.4103/0976-0105.177703
   Nelson JE, 2016, AM J GASTROENTEROL, V111, P852, DOI 10.1038/ajg.2016.51
   Nerurkar PV, 2011, J NEUROINFLAMM, V8, DOI 10.1186/1742-2094-8-64
   Norgaard SA, 2018, LAB ANIM-UK, V52, P373, DOI 10.1177/0023677217747915
   Nurminen V, 2018, BBA-GENE REGUL MECH, V1861, P697, DOI 10.1016/j.bbagrm.2018.05.006
   Oliveira WH, 2016, BRAIN RES, V1644, P149, DOI 10.1016/j.brainres.2016.05.013
   Osei-Hyiaman D, 2005, J CLIN INVEST, V115, P1298, DOI 10.1172/JCI200523057
   Page Kathleen, 1996, P309
   Payne AN, 2012, OBES REV, V13, P799, DOI 10.1111/j.1467-789X.2012.01009.x
   Pi-Sunyer F, 2006, JAMA-J AM MED ASSOC, V295, P761, DOI 10.1001/jama.295.7.761
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Rochfort KD, 2015, BIOCHEM SOC T, V43, P702, DOI 10.1042/BST20140319
   Rosas-Vargas H, 2011, ARCH MED RES, V42, P482, DOI 10.1016/j.arcmed.2011.09.005
   Ryz NR, 2015, AM J PHYSIOL-GASTR L, V309, pG730, DOI 10.1152/ajpgi.00006.2015
   Sallam NA, 2021, J NEUROENDOCRINOL, V33, DOI 10.1111/jne.12965
   Sandoval DA, 2015, PHYSIOL REV, V95, P513, DOI 10.1152/physrev.00013.2014
   Savastano DM, 2005, J NUTR, V135, P1953, DOI 10.1093/jn/135.8.1953
   Shen J, 2013, MOL ASPECTS MED, V34, P39, DOI 10.1016/j.mam.2012.11.001
   Singh-Manoux A, 2012, NEUROLOGY, V79, P755, DOI 10.1212/WNL.0b013e3182661f63
   Skovso S, 2015, INT J OBESITY, V39, P1531, DOI 10.1038/ijo.2015.92
   Smolders J, 2011, J NEUROL SCI, V311, P37, DOI 10.1016/j.jns.2011.07.033
   Solas M, 2017, CURR OPIN PHARMACOL, V37, P87, DOI 10.1016/j.coph.2017.10.005
   Srinivasan K, 2004, METHOD FIND EXP CLIN, V26, P327, DOI 10.1358/mf.2004.26.5.831322
   Stio M, 2016, SCAND J GASTROENTERO, V51, P1193, DOI 10.1080/00365521.2016.1185463
   Strange RC, 2015, WORLD J DIABETES, V6, P896, DOI 10.4239/wjd.v6.i7.896
   Su DM, 2016, FRONT PHYSIOL, V7, DOI 10.3389/fphys.2016.00498
   Suman RK, 2016, ADV PHARMACOL SCI, V2016, DOI 10.1155/2016/9463476
   Szymczak-Pajor I, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21186644
   Taghizadeh Mohsen, 2013, Iranian Biomedical Journal, V17, P42, DOI 10.6091/ibj.1061.2012
   Tanokashira D, 2018, FEBS OPEN BIO, V8, P1104, DOI 10.1002/2211-5463.12436
   Ticinesi A, 2016, NUTRIENTS, V8, DOI 10.3390/nu8040186
   Tremaroli V, 2012, NATURE, V489, P242, DOI 10.1038/nature11552
   Turnbaugh PJ, 2008, CELL HOST MICROBE, V3, P213, DOI 10.1016/j.chom.2008.02.015
   VANDENBUUSE M, 1989, J PHARMACOL EXP THER, V248, P1189
   Wang S, 2016, J NUTR BIOCHEM, V36, P42, DOI 10.1016/j.jnutbio.2016.07.008
   Wang WY, 2015, ANN TRANSL MED, V3, DOI 10.3978/j.issn.2305-5839.2015.03.49
   Wang Zheng, 2019, Zhongguo Yi Xue Ke Xue Yuan Xue Bao, V41, P506, DOI 10.3881/j.issn.1000-503X.11243
   Waterhouse M, 2019, EUR J NUTR, V58, P2895, DOI 10.1007/s00394-018-1842-7
   Wimalawansa SJ, 2012, CURR OSTEOPOROS REP, V10, P4, DOI 10.1007/s11914-011-0094-8
   Wortsman J, 2000, AM J CLIN NUTR, V72, P690, DOI 10.1093/ajcn/72.3.690
   Wu SP, 2010, AM J PATHOL, V177, P686, DOI 10.2353/ajpath.2010.090998
   Yang YJ, 2019, NEUROPSYCHOPHARMACOL, V44, P2054, DOI 10.1038/s41386-019-0437-1
   Yin Y, 2012, EUR J CLIN INVEST, V42, P1189, DOI 10.1111/j.1365-2362.2012.02706.x
   Zhang M, 2016, WORLD J GASTROENTERO, V22, P8905, DOI 10.3748/wjg.v22.i40.8905
   Zhang X, 2015, SCI REP-UK, V5, DOI 10.1038/srep14405
   Zhang YG, 2013, TISSUE BARRIERS, V1, DOI 10.4161/tisb.23118
   Zhao B, 2013, J BIOL CHEM, V288, P15590, DOI 10.1074/jbc.M112.440784
   Zhao HW, 2012, BMC GASTROENTEROL, V12, DOI 10.1186/1471-230X-12-57
NR 125
TC 7
Z9 7
U1 2
U2 9
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0928-0987
EI 1879-0720
J9 EUR J PHARM SCI
JI Eur. J. Pharm. Sci.
PD MAR 1
PY 2022
VL 170
AR 106105
DI 10.1016/j.ejps.2021.106105
EA JAN 2022
PG 14
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 2Q6BN
UT WOS:000820505400002
PM 34942358
OA gold
DA 2023-06-08
ER

PT J
AU He, SY
   Qiu, XM
   Wang, YQ
   Su, ZQ
   Zhang, BY
   Wen, Z
   Yang, YF
   Xing, BF
   Hong, M
   Liao, R
AF He, S. -y.
   Qiu, X. M.
   Wang, Y. -q.
   Su, Z. Q.
   Zhang, B. -y.
   Wen, Z.
   Yang, Y. -f.
   Xing, B. -f.
   Hong, M.
   Liao, R.
TI Intervention effect of Potentilla discolor- Euonymus alatus on
   intestinal flora of type 2 diabetes mellitus rats
SO EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
LA English
DT Article
DE Type 2 diabetes mellitus; Potentilla discolor; Euonymus alatus;
   Intestinal flora
AB OBJECTIVE: With this study, we aimed at exploring the regulation mechanism of Potentilla discolor-Euonymus alatus on intesti-nal flora of T2DM (Type 2 Diabetes Mellitus) rats induced by high-fat diet combined with strepto-zotocin.MATERIALS AND METHODS: T2DM rats were induced by high-fat diet combined with strepto-zotocin. There were normal control group, mod-el group, metformin group, high-dose Chinese medicine group and low-dose Chinese medi-cine group. Each group included 10 rats. Normal control group: normal feeding, no modeling, or-dinary feed, and gavage of 0.9% normal saline. Model group: T2DM rats, high-fat diet, and ga-vage of 0.9% normal saline. Metformin group: T2DM rats, high-fat diet and fed with metformin solution. High-dose Chinese medicine group: T2DM rats, high-fat diet, and gavage of concen-trated Chinese medicine at a dose of 6 times the clinical dose. Low-dose Chinese medicine group: T2DM rats, high-fat diet, and gavage of concentrated Chinese medicine at a dose twice the clinical dose. The general situation of T2DM rats was observed, and the changes of intestinal flora were observed with 16SrDNA sequencing.RESULTS: The T2DM rats induced by high-fat diet combined with streptozotocin were mold-ed. After intervention, at the class level, the ra-tio of gamma-proteobacteria was 22.30% in the model group, 11.97% in the metformin group, 3.24% in the high-dose Chinese herbs group and 1.72% in the low-dose Chinese herbs group; the ratio of Erysipelothrix insidiosa was 4.73% in the model group, 4.68% in the metformin group, 3.93% in the high-dose Chinese herbsgroup and 2.92% in the low dose group; the ratio of Lactinobacillus was 2.30% in the model group, 0.01% in the met-formin group, 0.00% in the high-dose Chinese herbs group, and 0.00% low-dose Chinese herbs group; at the portal level, the Firmicutes/Bacte-roides was 0.88 in the normal control group, 3.40in the model group, 1.71 in the metformin group, 2.74 in high-dose Chinese medicine group, and 1.34 in low-dose Chinese medicine group; at the genus level, the relative abundance of Lactoba-cillus in the model group was 3.28%, that of Ak-kermansia was 1.99%, that of Shigella coli was 22.08%, and that of Vibrio phaseus was 7.67%. All of them were improved after the intervention of metformin and traditional Chinese medicine.CONCLUSIONS: Potentilla discolor-Euony-mus Alatus could improve the composition and structure of intestinal flora in T2DM rats and reg-ulate the diversity of intestinal flora. The ratio of Firmicutes/Bacteroidetes was adjusted, mainly to increase the number of Bacteroides; the flora related to intestinal barrier was adjusted, mainly to increase the number of Lactobacillus and Ak-kermansia bacteria.
C1 [He, S. -y.; Wang, Y. -q.; Su, Z. Q.; Zhang, B. -y.; Wen, Z.; Yang, Y. -f.; Xing, B. -f.; Hong, M.; Liao, R.] Guangdong Pharmaceut Univ, Affiliated Hosp 1, Guangzhou, Guangdong, Peoples R China.
   [Qiu, X. M.; Wang, Y. -q.] Guangzhou Med Univ, Affiliated Hosp 1, Guangzhou, Guangdong, Peoples R China.
C3 Guangdong Pharmaceutical University; Guangzhou Medical University
RP Liao, R (通讯作者)，Guangdong Pharmaceut Univ, Affiliated Hosp 1, Guangzhou, Guangdong, Peoples R China.
EM rayliao1985@163.com
FU Guangdong Medical Re- search Fund Project; Guang- dong College
   Students?; innovation and entrepreneurship training program; 
   [A2020601];  [S201910573059]
FX Funding This work was supported by the Guangdong Medical Re- search Fund
   Project (No. A2020601) , and by the Guang- dong College Students?
   innovation and entrepreneurship training program (No. S201910573059) .
CR Dahlen AD, 2022, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.807548
   Diez-Sainz E, 2022, J PHYSIOL BIOCHEM, V78, P485, DOI 10.1007/s13105-021-00837-6
   Guo LX, 2020, J PRACTICAL MED, V36, P1142
   Hariharan R, 2022, OBES REV, V23, DOI 10.1111/obr.13349
   Hosomi K, 2022, NAT COMMUN, V13, DOI 10.1038/s41467-022-32015-7
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Liu J, 2022, FRONT CELL INFECT MI, V12, DOI 10.3389/fcimb.2022.801331
   Michels N, 2022, OBES REV, V23, DOI 10.1111/obr.13409
   Qi QB, 2022, GUT, V71, P1095, DOI 10.1136/gutjnl-2021-324053
   Ren GF, 2022, AM J TRANSL RES, V14, P3207
   SantaCruz-Calvo S, 2022, NAT REV ENDOCRINOL, V18, P23, DOI 10.1038/s41574-021-00575-1
   Sharma S, 2019, J NUTR BIOCHEM, V63, P101, DOI 10.1016/j.jnutbio.2018.10.003
   Song ZY, 2022, COMPUT MATH METHOD M, V2022, DOI 10.1155/2022/5677073
   Zhao JY, 2022, NUTRIENTS, V14, DOI 10.3390/nu14020377
NR 14
TC 0
Z9 0
U1 2
U2 2
PU VERDUCI PUBLISHER
PI ROME
PA VIA GREGORIO VII, ROME, 186-00165, ITALY
SN 1128-3602
J9 EUR REV MED PHARMACO
JI Eur. Rev. Med. Pharmacol. Sci.
PY 2022
VL 26
IS 24
BP 9062
EP 9071
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 7Y1ID
UT WOS:000914641100002
PM 36591818
DA 2023-06-08
ER

PT J
AU Wang, ZC
   Wang, J
   Hu, JX
   Chen, Y
   Dong, BZ
   Wang, YG
AF Wang, Zhongchao
   Wang, Jing
   Hu, Jianxia
   Chen, Ying
   Dong, Bingzi
   Wang, Yangang
TI A comparative study of acarbose, vildagliptin and saxagliptin intended
   for better efficacy and safety on type 2 diabetes mellitus treatment
SO LIFE SCIENCES
LA English
DT Article
DE Type 2 diabetes mellitus; Acarbose; Saxagliptin; Vildagliptin; Efficacy;
   Intestinal flora
ID GUT MICROBIOTA; CHINESE PATIENTS; BLOOD-GLUCOSE; CELL FUNCTION;
   METFORMIN; INSULIN; MANAGEMENT; OBESITY; HBA1C; PATHOPHYSIOLOGY
AB As a complicated metabolic disorder, type 2 diabetes mellitus (T2DM) is becoming a major health concern worldwide. Drugs including acarbose, saxagliptin and vildagliptin are applied, but their efficacy is still required to be compared. Therefore, the study aimed to evaluate the efficacy and safety of acarbose, saxagliptin and vildagliptin in the treatment of T2DM. Ninety patients diagnosed with T2DM were treated with acarbose, saxagliptin and vildagliptin, respectively (30 patients for each drug). All patients were examined at 0, 4 and 12 weeks after treatment with vital signs recorded. Fasting blood glucose and blood biochemical indices were analyzed. In addition, fecal samples were taken for microbial macrogenome sequencing and safety evaluation within 12 weeks after treatment. Blood glucose level decreased at 4 and 12 weeks after treatment, and the total cholesterol (TC) and high-density lipoprotein (HDL) levels at 12 weeks were different. Genus abundance of intestinal flora was altered at different time points. Acarbose increased Butyricimonas level first and then decreased it during drug treatment. Saxagliptin increased Megamonas and decreased Turicibacter genus level gradually. Pseudomonas, Klebsiella, Blautia, Faecalibacterium and Roseburia levels fluctuated after Vildagliptin treatment, which increased fasting C-peptide level greater than the other two drugs. Saxagliptin showed higher adverse reactions than acarbose and vildagliptin. Collectively, acarbose, vildagliptin, and saxagliptin can effectively reduce the HbA1c level and affect the intestinal flora distribution in T2DM patients, and the adverse reactions of acarbose and vildagliptin are less than saxagliptin, providing alternative strategies for the treatment of T2DM.
C1 [Wang, Zhongchao; Chen, Ying; Dong, Bingzi; Wang, Yangang] Affiliated Hosp Qingdao Univ, Dept Endocrinol & Metab, 16 Jiangsu Rd, Qingdao 266000, Shandong, Peoples R China.
   [Wang, Jing] Affiliated Hosp Qingdao Univ, Dept Canc Radiotherapy, Qingdao 266000, Peoples R China.
   [Hu, Jianxia] Affiliated Hosp Qingdao Univ, Lab Thyroid Dis, Qingdao 266000, Peoples R China.
C3 Qingdao University; Qingdao University; Qingdao University
RP Wang, YG (通讯作者)，Affiliated Hosp Qingdao Univ, Dept Endocrinol & Metab, 16 Jiangsu Rd, Qingdao 266000, Shandong, Peoples R China.
EM wangyg1966@126.com
OI Chen, Ying/0000-0002-7772-343X
CR Bader G, 2013, DIABETES RES CLIN PR, V100, pE78, DOI 10.1016/j.diabres.2013.03.011
   Bajzer M, 2006, NATURE, V444, P1009, DOI 10.1038/4441009a
   Blackstone R, 2012, SURG OBES RELAT DIS, V8, P548, DOI 10.1016/j.soard.2012.05.005
   Brunkhorst C, 2005, RES MICROBIOL, V156, P851, DOI 10.1016/j.resmic.2005.03.008
   Copeland KC, 2013, PEDIATRICS, V131, P364, DOI 10.1542/peds.2012-3494
   Cox LM, 2014, CELL, V158, P705, DOI 10.1016/j.cell.2014.05.052
   D'Alessio DA, 2009, J CLIN ENDOCR METAB, V94, P81, DOI 10.1210/jc.2008-1135
   Dabbah MA, 2011, MED IMAGE ANAL, V15, P738, DOI 10.1016/j.media.2011.05.016
   Delzenne NM, 2015, DIABETOLOGIA, V58, P2206, DOI 10.1007/s00125-015-3712-7
   Derosa G, 2012, DIABETES TECHNOL THE, V14, P475, DOI 10.1089/dia.2011.0278
   Gao ZG, 2009, DIABETES, V58, P1509, DOI 10.2337/db08-1637
   Gde P, 2016, DIABETOLOGIA, V59, P2298, DOI 10.1007/s00125-016-4065-6
   Gobinath D, 2010, BRIT J NUTR, V104, P40, DOI 10.1017/S0007114510000243
   Gu SY, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0126704
   Henness S, 2006, DRUGS, V66, P1989, DOI 10.2165/00003495-200666150-00007
   Henry RR, 2011, DIABETES OBES METAB, V13, P850, DOI 10.1111/j.1463-1326.2011.01417.x
   Kadam PD, 2016, INT UROGYNECOL J, V27, P505, DOI 10.1007/s00192-016-2952-5
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Karyekar CS, 2013, INT J CLIN PRACT, V67, P759, DOI 10.1111/ijcp.12212
   Kautzky-Willer A, 2016, ENDOCR REV, V37, P278, DOI 10.1210/er.2015-1137
   Keating GM, 2010, DRUGS, V70, P2089, DOI 10.2165/11206370-000000000-00000
   Kim MK, 2011, DIABETES RES CLIN PR, V92, P322, DOI 10.1016/j.diabres.2011.01.022
   Kulasa K, 2010, CORE EVID, V5, P23, DOI 10.2147/CE.S8006
   Lee S, 2012, J CLIN PHARM THER, V37, P553, DOI 10.1111/j.1365-2710.2012.01339.x
   Li CL, 2011, DIABETES RES CLIN PR, V92, P57, DOI 10.1016/j.diabres.2010.12.033
   Li FF, 2016, BIOMED REP, V5, P461, DOI 10.3892/br.2016.744
   Lukashevich V, 2013, VASC HEALTH RISK MAN, V9, P21, DOI 10.2147/VHRM.S39300
   Ma QT, 2019, BIOMED PHARMACOTHER, V117, DOI 10.1016/j.biopha.2019.109138
   Oboh G, 2016, J FOOD DRUG ANAL, V24, P627, DOI 10.1016/j.jfda.2016.03.003
   Olivares M, 2018, DIABETOLOGIA, V61, P1838, DOI 10.1007/s00125-018-4647-6
   Pan C, 2012, DIABETES OBES METAB, V14, P737, DOI 10.1111/j.1463-1326.2012.01593.x
   Ripsin CM, 2009, AM FAM PHYSICIAN, V79, P29
   Sakamoto M, 2009, INT J SYST EVOL MICR, V59, P1748, DOI 10.1099/ijs.0.007674-0
   Sato D, 2013, ENDOCR J, V60, P847, DOI 10.1507/endocrj.EJ12-0288
   Schweizer A, 2011, VASC HEALTH RISK MAN, V7, P49, DOI 10.2147/VHRM.S16925
   Sharma M, 2016, BMJ OPEN, V6, DOI 10.1136/bmjopen-2015-010210
   Shubrook J, 2011, CLIN MED INSIGHTS-EN, V4, P1, DOI 10.4137/CMED.S5114
   Simren M, 2013, GUT, V62, P159, DOI 10.1136/gutjnl-2012-302167
   Sjostrand M, 2014, DIABETES RES CLIN PR, V105, P185, DOI 10.1016/j.diabres.2014.05.006
   Soeters Maarten R, 2010, Ned Tijdschr Geneeskd, V154, pA2113
   Sohail MU, 2017, J DIABETES RES, V2017, DOI 10.1155/2017/9631435
   Su ZM, 2015, EXP THER MED, V9, P961, DOI 10.3892/etm.2015.2199
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Turnbaugh PJ, 2009, NATURE, V457, P480, DOI 10.1038/nature07540
   Uzui H, 2011, J DIABETES INVEST, V2, P148, DOI 10.1111/j.2040-1124.2010.00079.x
   Wang JS, 2017, J DIABETES, V9, P248, DOI 10.1111/1753-0407.12406
   Wang L, 2016, SCI REP-UK, V6, DOI [10.1038/srep38380, 10.1038/srep33251, 10.1038/srep20004]
   Yang H, 2016, ONCOTARGET, V7, P16227, DOI 10.18632/oncotarget.7583
   Zaccardi F, 2016, DIABETES OBES METAB, V18, P783, DOI 10.1111/dom.12670
   Zaccardi F, 2016, POSTGRAD MED J, V92, P63, DOI 10.1136/postgradmedj-2015-133281
   Zhang CH, 2010, ISME J, V4, P232, DOI 10.1038/ismej.2009.112
   Zhang JP, 2016, J DIABETES, V8, P559, DOI 10.1111/1753-0407.12337
   Zhang XY, 2017, DIABETES THER, V8, P293, DOI 10.1007/s13300-017-0226-y
   Zhao LP, 2018, SCIENCE, V359, P1151, DOI 10.1126/science.aao5774
   Zhao LP, 2013, NAT REV MICROBIOL, V11, P639, DOI 10.1038/nrmicro3089
NR 55
TC 9
Z9 9
U1 1
U2 32
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD JUN 1
PY 2021
VL 274
AR 119069
DI 10.1016/j.lfs.2021.119069
EA MAR 2021
PG 8
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA RH2PZ
UT WOS:000636068700002
PM 33460667
DA 2023-06-08
ER

PT J
AU Chung, E
   Elmassry, MM
   Kottapalli, P
   Kottapalli, KR
   Kaur, G
   Dufour, JM
   Wright, K
   Ramalingam, L
   Moustaid-Moussa, N
   Wang, R
   Hamood, AN
   Shen, CL
AF Chung, Eunhee
   Elmassry, Moamen M.
   Kottapalli, Pratibha
   Kottapalli, Kameswara Rao
   Kaur, Gurvinder
   Dufour, Jannette M.
   Wright, Kandis
   Ramalingam, Latha
   Moustaid-Moussa, Naima
   Wang, Rui
   Hamood, Abdul N.
   Shen, Chwan-Li
TI Metabolic benefits of annatto-extracted tocotrienol on glucose
   homeostasis, inflammation, and gut microbiome
SO NUTRITION RESEARCH
LA English
DT Article
ID AKKERMANSIA-MUCINIPHILA; OBESITY; DIET; CONTRIBUTES
AB Emerging evidence suggests that the gut microbiome plays an important role in the pathophysiology of both obesity and type 2 diabetes mellitus. We previously reported that dietary annatto-extracted tocotrienol exerts beneficial effects by modulating inflammatory responses in mice fed a high-fat diet (HFD). The purpose of this study was to test the hypothesis that tocotrienol supplementation when combined with an HFD would result in an altered gut microbiota composition. For 14 weeks, forty-eight male C57BL/6) mice were assigned to 4 groups-low-fat diet, HFD, HFD supplemented with annatto-extracted tocotrienol at 800 mg/kg diet (AT), and HFD supplemented with metformin at 200 mg/kg diet. Glucose homeostasis was assessed by glucose and insulin tolerance tests, serum and pancreas insulin levels, and histological assessments of insulin and glucagon in pancreatic tissue. The concentrations of adipokines were measured in white adipose tissues. For the gut microbiome analysis, cecal content was collected, DNA was extracted, and 16S rRNA gene sequencing was performed. AT supplementation improved glucose homeostasis and lowered resistin, leptin, and interleukin-6 levels in white adipose tissue. Relative to the HFD group, AT-supplemented mice showed a decrease in the Firmicutes to Bacteroidetes ratio and had a lower abundance of Ruminococcus lactaris, Dorea longicatena, and Lachnospiraceae family. The relative abundance of Akkermansia muciniphila was increased in the AT group compared to the low-fat diet group. The association between the metabolic improvements and the identified bacterial taxa suggests a potential metabolic modulation caused by AT supplementation through the gut microbiota composition in mice fed an HFD. (C) 2020 The Authors. Published by Elsevier Inc.
C1 [Chung, Eunhee] Univ Texas San Antonio, Dept Kinesiol Hlth & Nutr, San Antonio, TX USA.
   [Elmassry, Moamen M.] Texas Tech Univ, Dept Biol Sci, Lubbock, TX 79430 USA.
   [Kottapalli, Pratibha] St Jude Childrens Res Hosp, Hartwell Ctr, 332 N Lauderdale St, Memphis, TN 38105 USA.
   [Kottapalli, Kameswara Rao] AUA Coll Med, Antigua, Jamaica.
   [Kaur, Gurvinder; Dufour, Jannette M.] Texas Tech Univ, Dept Med Educ, Hlth Sci Ctr, Lubbock, TX 79430 USA.
   [Kaur, Gurvinder; Dufour, Jannette M.; Ramalingam, Latha; Moustaid-Moussa, Naima; Shen, Chwan-Li] Texas Tech Univ, Ctr Excellence Integrat Hlth, Hlth Sci Ctr, Lubbock, TX 79430 USA.
   [Dufour, Jannette M.; Wright, Kandis] Texas Tech Univ, Dept Cell Biol & Biochem, Hlth Sci Ctr, Lubbock, TX 79430 USA.
   [Kaur, Gurvinder; Dufour, Jannette M.; Ramalingam, Latha; Moustaid-Moussa, Naima; Shen, Chwan-Li] Texas Tech Univ, Obes Res Inst, Lubbock, TX 79430 USA.
   [Ramalingam, Latha; Moustaid-Moussa, Naima] Texas Tech Univ, Dept Nutr Sci, Lubbock, TX 79430 USA.
   [Wang, Rui; Shen, Chwan-Li] Texas Tech Univ, Dept Pathol, Hlth Sci Ctr, 1A096B,3601 Fourth, Lubbock, TX 79430 USA.
   [Dufour, Jannette M.; Hamood, Abdul N.] Texas Tech Univ, Dept Immunol & Mol Microbiol, Hlth Sci Ctr, Lubbock, TX 79430 USA.
   [Hamood, Abdul N.] Texas Tech Univ, Dept Surg, Hlth Sci Ctr, Lubbock, TX 79430 USA.
C3 University of Texas System; University of Texas at San Antonio (UTSA);
   Texas Tech University System; Texas Tech University; St Jude Children's
   Research Hospital; Texas Tech University System; Texas Tech University;
   Texas Tech University Health Science Center; Texas Tech University
   System; Texas Tech University; Texas Tech University Health Science
   Center; Texas Tech University System; Texas Tech University; Texas Tech
   University Health Science Center; Texas Tech University System; Texas
   Tech University; Texas Tech University System; Texas Tech University;
   Texas Tech University System; Texas Tech University; Texas Tech
   University Health Science Center; Texas Tech University System; Texas
   Tech University; Texas Tech University Health Science Center; Texas Tech
   University System; Texas Tech University; Texas Tech University Health
   Science Center
RP Shen, CL (通讯作者)，Texas Tech Univ, Dept Pathol, Hlth Sci Ctr, 1A096B,3601 Fourth, Lubbock, TX 79430 USA.
EM eunhee.chung@utsa.edu; moamen.elmassry@ttu.edu; kottapallisri@gmail.com;
   gurvinder.kaur@ttuhsc.edu; jannette.dufour@ttuhsc.edu;
   kandis.wright@ttuhsc.edu; latha.Ramalingam@ttu.edu;
   naima.moustaid-moussa@ttu.edu; rui.wang@ttuhsc.edu;
   abdul.hamood@ttuhsc.edu; leslie.shen@ttuhsc.edu
RI Elmassry, Moamen M/J-9335-2015; Chung, Eunhee/AAX-6863-2020; Ramalingam,
   Latha/M-8438-2015
OI Elmassry, Moamen M/0000-0002-1193-7822; Chung,
   Eunhee/0000-0002-4501-9333; 
FU American River Nutrition, LLC, Hadley, MA, USA; Obesity Research
   Institute; Center of Excellence for Integrative Health; University of
   Texas at San Antonio, Office of the Vice President for Research; Ted
   Nash Long Life Foundation; Jasper L. and Jack Denton Wilson Foundation
FX This study was supported by American River Nutrition, LLC, Hadley, MA,
   USA, and in part by the Obesity Research Institute and the Center of
   Excellence for Integrative Health. We thank Michael D. Tomison for
   animal care and fecal DNA extraction. We thank Katherine A. Grue for
   cecal sample collection. We thank Monica Trevino for critical reading of
   themanuscript. EC was supported in part by the University of Texas at
   San Antonio, Office of the Vice President for Research. JMD and GK were
   supported in part by The Ted Nash Long Life Foundation and The Jasper L.
   and Jack Denton Wilson Foundation. The sequencing data of each sample
   have been deposited under BioProject accession number PRJNA551310 in the
   National Center for Biotechnology Information BioProject database.
CR Ahsan H, 2014, NUTR METAB, V11, DOI 10.1186/1743-7075-11-52
   Allen L, 2017, J NUTR BIOCHEM, V48, P128, DOI 10.1016/j.jnutbio.2017.07.003
   Allin KH, 2018, DIABETOLOGIA, V61, P810, DOI 10.1007/s00125-018-4550-1
   Baothman OA, 2016, LIPIDS HEALTH DIS, V15, DOI 10.1186/s12944-016-0278-4
   Barka EA, 2016, MICROBIOL MOL BIOL R, V80, P1, DOI 10.1128/MMBR.00019-15
   Bisanz JE., 2019, 541797 BIORXIV, P541797, DOI [10.1101/541797, DOI 10.1101/541797]
   Bolyen E, 2019, NAT BIOTECHNOL, V37, P852, DOI 10.1038/s41587-019-0209-9
   Brahe LK, 2015, NUTR DIABETES, V5, DOI 10.1038/nutd.2015.9
   Caricilli AM, 2014, CURR OPIN CLIN NUTR, V17, P312, DOI 10.1097/MCO.0000000000000067
   Casanova-Marti A, 2018, FOOD FUNCT, V9, P1672, DOI [10.1039/c7fo02028g, 10.1039/C7FO02028G]
   Chavez-Carbajal A, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20020438
   Dao MC, 2016, GUT, V65, P426, DOI 10.1136/gutjnl-2014-308778
   DeSantis TZ, 2006, APPL ENVIRON MICROB, V72, P5069, DOI 10.1128/AEM.03006-05
   Dufour JM, 2005, TISSUE ENG, V11, P1323, DOI 10.1089/ten.2005.11.1323
   Duncan SH, 2008, INT J OBESITY, V32, P1720, DOI 10.1038/ijo.2008.155
   Etxeberria U, 2017, MOL NUTR FOOD RES, V61, DOI 10.1002/mnfr.201500906
   Everard A, 2014, ISME J, V8, P2116, DOI 10.1038/ismej.2014.45
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Everard A, 2011, DIABETES, V60, P2775, DOI 10.2337/db11-0227
   Finlayson A, 2015, WORLD J GASTRO ENDOS, V7, P1103, DOI [10.4253/wjge.v7.i13.1103, 10.4291/wjgp.v6.i4.110]
   Griffin LE, 2017, FOOD FUNCT, V8, P3510, DOI [10.1039/c7fo01236e, 10.1039/C7FO01236E]
   Guo YJ, 2018, FOOD FUNCT, V9, P4317, DOI 10.1039/c8fo00444g
   Henderson LJ, 2014, PLOS ONE, V9
   Hwang N, 2017, GENES-BASEL, V8, DOI 10.3390/genes8120350
   Jakubowicz D, 2013, J NUTR BIOCHEM, V24, P1, DOI 10.1016/j.jnutbio.2012.07.008
   Jumpertz R, 2011, AM J CLIN NUTR, V94, P58, DOI 10.3945/ajcn.110.010132
   Kameyama K, 2014, MICROBES ENVIRON, V29, P427, DOI 10.1264/jsme2.ME14054
   Kang SS, 2014, MOL NEURODEGENER, V9, DOI 10.1186/1750-1326-9-36
   Karlsson F, 2013, DIABETES, V62, P3341, DOI 10.2337/db13-0844
   Kasselman LJ, 2018, ATHEROSCLEROSIS, V271, P203, DOI 10.1016/j.atherosclerosis.2018.02.036
   Klindworth Anna, 2013, Nucleic Acids Res, V41, pe1, DOI 10.1093/nar/gks808
   Kobyliak N, 2016, NUTR METAB, V13, DOI 10.1186/s12986-016-0067-0
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Le Roy T, 2019, BMC BIOL, V17, DOI 10.1186/s12915-019-0715-8
   Lecomte V, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0126931
   Li XF, 2016, SCI REP-UK, V6, DOI 10.1038/srep32953
   Masumoto S, 2016, SCI REP-UK, V6, DOI 10.1038/srep31208
   Miao V, 2010, ANTON LEEUW INT J G, V98, P143, DOI 10.1007/s10482-010-9440-6
   Million M, 2018, HUM MICROBIOME J, V10, P27, DOI [10.1016/j.humic.2018.07.002, DOI 10.1016/J.HUMIC.2018.07.002]
   Muid S, 2016, FOOD NUTR RES, V60, DOI 10.3402/fnr.v60.31526
   Murphy EF, 2010, GUT, V59, P1635, DOI 10.1136/gut.2010.215665
   Naito Y, 2018, J CLIN BIOCHEM NUTR, V63, P33, DOI 10.3164/jcbn.18-57
   Napolitano A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100778
   Naseer MI, 2014, CNS NEUROL DISORD-DR, V13, P305, DOI 10.2174/18715273113126660147
   Panfili G, 2003, J AGR FOOD CHEM, V51, P3940, DOI 10.1021/jf030009v
   Reimer RA, 2014, J ENDOCRINOL, V220, P361, DOI 10.1530/JOE-13-0484
   Rena G, 2013, DIABETOLOGIA, V56, P1898, DOI 10.1007/s00125-013-2991-0
   Roopchand DE, 2015, DIABETES, V64, P2847, DOI 10.2337/db14-1916
   Schwiertz A, 2010, OBESITY, V18, P190, DOI 10.1038/oby.2009.167
   Seipke RF, 2012, FEMS MICROBIOL REV, V36, P862, DOI 10.1111/j.1574-6976.2011.00313.x
   Sharoff CG, 2010, AM J PHYSIOL-ENDOC M, V298, pE815, DOI 10.1152/ajpendo.00517.2009
   Shen CL, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-29063-9
   Shen J, 2013, MOL ASPECTS MED, V34, P39, DOI 10.1016/j.mam.2012.11.001
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Sookwong P, 2010, J AGR FOOD CHEM, V58, P3350, DOI 10.1021/jf903663k
   Turnbaugh PJ, 2009, NATURE, V457, P480, DOI 10.1038/nature07540
   Wakita Y, 2018, BMC MICROBIOL, V18, DOI 10.1186/s12866-018-1311-8
   Wang JC, 2018, J NUTR BIOCHEM, V56, P55, DOI 10.1016/j.jnutbio.2018.01.005
   Wei XY, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-22094-2
   Wessels B, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100525
   Yerlikaya A, 2017, INT UROL NEPHROL, V49, P1611, DOI 10.1007/s11255-017-1544-8
   Zakrzewski M, 2017, BIOINFORMATICS, V33, P782, DOI 10.1093/bioinformatics/btw725
   Zhang XQ, 2015, SCI REP-UK, V5, DOI 10.1038/srep10737
   Zhou J, 2018, J NUTR BIOCHEM, V61, P68, DOI 10.1016/j.jnutbio.2018.07.018
   Zietak M, 2016, CELL METAB, V23, P1216, DOI 10.1016/j.cmet.2016.05.001
NR 65
TC 22
Z9 22
U1 3
U2 5
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0271-5317
EI 1879-0739
J9 NUTR RES
JI Nutr. Res.
PD MAY
PY 2020
VL 77
BP 97
EP 107
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA MK1BN
UT WOS:000548521300009
PM 32438021
OA hybrid, Green Published
DA 2023-06-08
ER

PT J
AU Park, S
   Yuan, H
   Zhang, T
   Wu, X
   Huang, SK
   Cho, SM
AF Park, Sunmin
   Yuan, Heng
   Zhang, Ting
   Wu, Xuangao
   Huang, Shao Kai
   Cho, Song Mee
TI Long-term silk peptide intake promotes skeletal muscle mass, reduces
   inflammation, and modulates gut microbiota in middle-aged female rats
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Sarcopenia; Skeletal muscles; Gut microbiota; Butyrate; Grip strength
AB Aging alters body composition to induce sarcopenia, particularly in women, but the mechanism remains unclear. We hypothesized that silk peptide(SP) intake could prevent an age-related decrease in muscle mass and strength in middle-aged female rats and explored the action mechanism. After the acute intake of SP and defatted soybean peptides, serum concentrations of amino acids were measured in ten middle-aged rats in each group. Forty 12 month-old female Sprague-Dawley rats were fed a high-fat and high-carbohydrate diet for 12 weeks including 0.5 g casein/kg body weight(BW)/day(Aged), 0.15 g SP plus 0.35 g casein/kg BW/day(Low-SP), 0.5 g SP/kg BW/ day(High-SP), or 40 mg metformin plus 0.5 g casein/kg BW/day(Metformin). Ten rats aged 7-week old(Young) had the same treatment as the Aged-group. The body composition, grip strength, glucose metabolism, intestinal tissue morphology, and gut microbiota were also determined. After an acute consumption, total amino acids were more quickly absorbed and maintained at higher levels in SP than soybean peptides. Lean body mass(LBM) and grip strength were lower in the Aged-group than the Young and Low-SP groups, and the High-SP regimen increased these parameters as much as the Young-group. Serum concentrations and mRNA expression of TNF-? in the gastrocnemius and quadriceps muscles were higher in the Aged-group than the Young-group, whereas SP intake reduced their serum levels and skeletal muscles. Glucose and insulin tolerance indicated that insulin resistance was elevated in the Aged-group compared to the Young-group, while Low-SP and High-SP alleviated them as much as the Young-group. High-SP increased serum propionate and butyrate concentrations compared to the Aged-group. SP intake increased the relative abundance of Bacteroides and Prevotella and decreased Blautia and Clostridium in the feces. In conclusion, SP intake protects against a decrease in lean body mass and grip strength in middle-aged female rats. The protection was partly related to maintaining higher serum concentrations of total amino acids after SP consumption and decreasing inflammation and insulin resistance through gut microbiota modulation.
C1 [Park, Sunmin; Cho, Song Mee] Hoseo Univ, Obes Diabet Res Ctr, Dept Food & Nutr, Asan 31499, South Korea.
   [Park, Sunmin; Yuan, Heng; Zhang, Ting; Wu, Xuangao; Huang, Shao Kai] Hoseo Univ, Dept Bioconvergence Syst, Asan 31499, South Korea.
C3 Hoseo University; Hoseo University
RP Park, S (通讯作者)，Hoseo Univ, Obes Diabet Res Ctr, Food & Nutr, 165 Sechul Ri, Asan 336795, Chungnam Do, South Korea.
EM smpark@hoseo.edu
RI Park, Sun/GSD-9620-2022
FU Ministry of Trade, Industry Energy (MOTIE); Korea Institute for
   Advancement of Technology (KIAT) through the Encouragement Program for
   The Industries of Economic Cooperation Region [P0004746]
FX This research was supported by the Ministry of Trade, Industry & Energy
   (MOTIE) , and Korea Institute for Advancement of Technology (KIAT)
   through the Encouragement Program for The Industries of Economic
   Cooperation Region (No. P0004746) .
CR Abrigo J, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/9047821
   Alves A, 2019, NUTRIENTS, V11, DOI 10.3390/nu11061356
   An HJ, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21165678
   Anagnostis P, 2020, CALCIFIED TISSUE INT, V107, P453, DOI 10.1007/s00223-020-00742-y
   Anderson LJ, 2017, ADV EXP MED BIOL, V1043, P153, DOI 10.1007/978-3-319-70178-3_9
   Araujo CG, 2019, ARQ BRAS CARDIOL, V112, P747, DOI 10.5935/abc.20190097
   Cabrera D, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19051339
   Capurso C, 2020, NUTRIENTS, V12, DOI 10.3390/nu12010035
   CHIU CJ, 1970, ARCH SURG-CHICAGO, V101, P478
   Dong X, 2020, INT J BIOL MACROMOL, V150, P1061, DOI 10.1016/j.ijbiomac.2019.10.111
   Endo Y, 2020, FRONT PHYSIOL, V11, DOI 10.3389/fphys.2020.00874
   Enns DL, 2010, SPORTS MED, V40, P41, DOI 10.2165/11319760-000000000-00000
   Farag NH, 2003, ANN BEHAV MED, V26, P134, DOI 10.1207/S15324796ABM2602_05
   Ikeda K, 2019, J STEROID BIOCHEM, V191, DOI 10.1016/j.jsbmb.2019.105375
   Jeong SY, 2018, NUTRIENTS, V10, DOI 10.3390/nu10030288
   Keller K, 2019, WIEN MED WOCHENSCHR, V169, P157, DOI 10.1007/s10354-018-0618-2
   Kim S, 2018, GERONTOLOGY, V64, P513, DOI 10.1159/000490615
   Kitada M, 2019, EBIOMEDICINE, V43, P632, DOI 10.1016/j.ebiom.2019.04.005
   Ksenofontov AL, 2017, BIOCHEMISTRY-MOSCOW+, V82, P1183, DOI 10.1134/S000629791710011X
   Lahiri S, 2019, SCI TRANSL MED, V11, DOI 10.1126/scitranslmed.aan5662
   Laurent MR, 2019, MATURITAS, V122, P51, DOI 10.1016/j.maturitas.2019.01.006
   Lee K, 2020, CELLS-BASEL, V9, DOI 10.3390/cells9020377
   Lee K, 2020, NUTRIENTS, V12, DOI 10.3390/nu12010201
   Lee S, 2012, EUR J CLIN NUTR, V66, P1366, DOI 10.1038/ejcn.2012.142
   Lipsitz LA., 2012, PRIMER AUTONOMIC NER, P271, DOI DOI 10.1016/B978-0-12-386525-0.00056-1
   Little RD, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-06581-6
   Long M, 2018, NUTRIENTS, V10, DOI 10.3390/nu10070810
   Morley JE, 2017, CURR PHARM DESIGN, V23, P4484, DOI 10.2174/1381612823666161123150032
   Nay K, 2019, AM J PHYSIOL-ENDOC M, V317, pE158, DOI 10.1152/ajpendo.00521.2018
   Ni YH, 2019, MOL NUTR FOOD RES, V63, DOI 10.1002/mnfr.201900603
   Nivedita S., 2014, Journal of the Institution of Engineers (India): Series E (Chemical and Textile Engineering), V95, P57, DOI 10.1007/s40034-014-0034-0
   Park S, 2020, EXP THER MED, V19, P3611, DOI 10.3892/etm.2020.8636
   Park S, 2020, NUTRIENTS, V12, DOI 10.3390/nu12020311
   Park S, 2019, EVID-BASED COMPL ALT, V2019, DOI 10.1155/2019/8063121
   Park S, 2018, EXP BIOL MED, V243, P882, DOI 10.1177/1535370218789068
   Park S, 2018, AM J PHYSIOL-ENDOC M, V315, pE99, DOI 10.1152/ajpendo.00005.2018
   Park S, 2011, EUR J NUTR, V50, P107, DOI 10.1007/s00394-010-0120-0
   Pecinova A, 2019, BIOFACTORS, V45, P703, DOI 10.1002/biof.1548
   Ponti F, 2020, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00861
   REEVES PG, 1993, J NUTR, V123, P1939, DOI 10.1093/jn/123.11.1939
   Rodrigues ACZ, 2019, ACTA PHYSIOL, V225, DOI 10.1111/apha.13195
   Rus GE, 2020, NUTR DIET, V77, P90, DOI 10.1111/1747-0080.12608
   Ryuk JA, 2019, J CLIN BIOCHEM NUTR, V65, P223, DOI 10.3164/jcbn.19-15
   SEBOKOVA E, 1993, ANN NY ACAD SCI, V683, P218
   Takeshita H, 2017, SCI REP-UK, V7, DOI 10.1038/srep42323
   Wu CN, 2020, J DIABETES RES, V2020, DOI 10.1155/2020/9368583
   Yan-Do R, 2017, ENDOCRINOLOGY, V158, P1064, DOI 10.1210/en.2017-00148
   Yang HJ, 2019, NUTRIENTS, V11, DOI 10.3390/nu11071503
   Yang HJ, 2016, MENOPAUSE, V23, P197, DOI 10.1097/GME.0000000000000521
   Yang HJ, 2016, NUTRITION, V32, P129, DOI 10.1016/j.nut.2015.07.012
   Zhang HQ, 2018, NUTRIENTS, V10, DOI 10.3390/nu10030364
NR 51
TC 7
Z9 8
U1 4
U2 10
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD MAY
PY 2021
VL 137
AR 111415
DI 10.1016/j.biopha.2021.111415
EA FEB 2021
PG 11
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA RC8MV
UT WOS:000633048900004
PM 33761619
OA gold
DA 2023-06-08
ER

PT J
AU Saydam, BO
   Yildiz, BO
AF Saydam, Basak Ozgen
   Yildiz, Bulent O.
TI Gut-Brain Axis and Metabolism in Polycystic Ovary Syndrome
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Review
DE Polycystic ovary syndrome; ghrelin; GLP-1; GIP; PYY; CCK; appetite;
   microbiota
ID GLUCAGON-LIKE PEPTIDE-1; GASTRIC-INHIBITORY POLYPEPTIDE; CIRCULATING
   GHRELIN LEVELS; DEPENDENT INSULINOTROPIC POLYPEPTIDE; DECREASES
   FOOD-INTAKE; HIGH-FAT DIET; WEIGHT-LOSS; PLASMA GHRELIN; OBESE WOMEN;
   POSTPRANDIAL GHRELIN
AB Polycystic ovary syndrome (PCOS) is a common and complex endocrine disorder, often accompanied and complicated by insulin resistance, glucose intolerance and obesity. Gut, brain and metabolism are highly related with each other in obesity and diabetes as well as in PCOS. Central nervous system regulates food intake through complex interactions of homeostatic and hedonic systems while gastrointestinal system contributes to food intake and metabolism via orexigenic and anorexigenic gastrointestinal hormones. Ghrelin is the only circulating orexigenic hormone whereas anorexigenic peptides include glucagon like peptide-1 (GLP-1), gastric inhibitory peptide (GIP), peptide YY (PYY) and cholecystokinin (CCK). Compared to healthy women, patients with PCOS show decreased or unaltered fasting ghrelin levels, along with decreased or unaltered postprandial suppression of this hormone. GLP-1, PYY and CCK show unaltered or decreased levels both in fasting and postprandial states in PCOS whereas fasting levels of another gut hormone, GIP is either unaltered or increased. Dietary interventions associated with weight loss or short term oral contraceptive use in PCOS do not alter fasting or postprandial levels of these hormones. However use of metformin is associated with an increase in ghrelin, PYY, GLP-1 and GIP in women with PCOS. GLP-1 agonists and bariatric surgery, both having a significant impact on gut-brain axis, appear to be effective therapeutic options in obese women with PCOS. Finally, alterations in gut microbiota and possible interactions with gut-brain axis in PCOS is a topic of interest. Understanding the relationship between PCOS and homeostatic and hedonic systems, gastrointestinal hormones, and gut microbiota as well as potential effects of different therapeutic interventions on these systems will provide further understanding and novel treatment opportunities for this syndrome.
C1 [Saydam, Basak Ozgen; Yildiz, Bulent O.] Hacettepe Univ, Sch Med, Dept Internal Med, TR-06100 Ankara, Turkey.
   [Yildiz, Bulent O.] Div Endocrinol & Metab, TR-06100 Ankara, Turkey.
C3 Hacettepe University
RP Yildiz, BO (通讯作者)，Hacettepe Univ, Fac Med, Dept Internal Med, Div Endocrinol & Metab, TR-06100 Ankara, Turkey.
EM yildizbo@yahoo.com
RI Saydam, Basak Ozgen/AAH-1446-2019; Yildiz, Bulent/ABD-7781-2020
OI Saydam, Basak Ozgen/0000-0001-9457-8919; Yildiz,
   Bulent/0000-0003-1797-7662
CR Abbott CR, 2005, BRAIN RES, V1044, P127, DOI 10.1016/j.brainres.2005.03.011
   ADRIAN TE, 1985, GASTROENTEROLOGY, V89, P1070, DOI 10.1016/0016-5085(85)90211-2
   ALIRACHEDI A, 1984, HISTOCHEMISTRY, V80, P487, DOI 10.1007/BF00495439
   Arusoglu G, 2013, J CLIN ENDOCR METAB, V98, P4475, DOI 10.1210/jc.2013-1526
   Asakawa A, 2001, GASTROENTEROLOGY, V120, P337, DOI 10.1053/gast.2001.22158
   Astrup A, 2009, LANCET, V374, P1606, DOI 10.1016/S0140-6736(09)61375-1
   Aydin K, 2014, CLIN ENDOCRINOL, V81, P588, DOI 10.1111/cen.12468
   Baggio LL, 2007, GASTROENTEROLOGY, V132, P2131, DOI 10.1053/j.gastro.2007.03.054
   Barazzoni R, 2013, OBESITY, V21, P718, DOI 10.1002/oby.20272
   Barber TM, 2008, EUR J ENDOCRINOL, V158, P511, DOI 10.1530/EJE-07-0683
   Batterham RL, 2007, NATURE, V450, P106, DOI 10.1038/nature06212
   Batterham RL, 2003, ANN NY ACAD SCI, V994, P162, DOI 10.1111/j.1749-6632.2003.tb03176.x
   Batterham RL, 2002, NATURE, V418, P650, DOI 10.1038/nature00887
   Batterham RL, 2003, NEW ENGL J MED, V349, P941, DOI 10.1056/NEJMoa030204
   Berridge KC, 2003, TRENDS NEUROSCI, V26, P507, DOI 10.1016/S0166-2236(03)00233-9
   Berthoud HR, 2006, OBESITY, V14, P197
   Berthoud HR, 2011, AM J PHYSIOL-REG I, V300, pR1266, DOI 10.1152/ajpregu.00028.2011
   Bidzinska-Speichert B, 2012, GYNECOL ENDOCRINOL, V28, P195, DOI 10.3109/09513590.2011.593670
   Borg CM, 2006, BRIT J SURG, V93, P210, DOI 10.1002/bjs.5227
   Boyd KA, 2003, AM J PHYSIOL-GASTR L, V284, pG188, DOI 10.1152/ajpgi.00375.2002
   Brown J C, 1975, Recent Prog Horm Res, V31, P487
   BUFFA R, 1975, HISTOCHEMISTRY, V43, P249, DOI 10.1007/BF00499706
   Buhmann H, 2014, BEST PRACT RES CL GA, V28, P559, DOI 10.1016/j.bpg.2014.07.003
   Cabou Cendrine, 2011, Rev Diabet Stud, V8, P418, DOI 10.1900/RDS.2011.8.418
   Carr RD, 2010, J CLIN ENDOCR METAB, V95, P872, DOI 10.1210/jc.2009-2054
   Cassar S, 2015, CLIN ENDOCRINOL, V83, P50, DOI 10.1111/cen.12619
   Chakravartty S, 2015, CURR OBES REP, V4, P262, DOI 10.1007/s13679-015-0158-7
   Chandarana K, 2011, DIABETES, V60, P810, DOI 10.2337/db10-0566
   Chandra Rashmi, 2007, Curr Opin Endocrinol Diabetes Obes, V14, P63, DOI 10.1097/MED.0b013e3280122850
   Chang CL, 2014, J CLIN ENDOCR METAB, V99, pE2539, DOI 10.1210/jc.2014-1180
   Chia CW, 2009, DIABETES, V58, P1342, DOI 10.2337/db08-0958
   Clemente JC, 2012, CELL, V148, P1258, DOI 10.1016/j.cell.2012.01.035
   CONTER RL, 1987, AM J PHYSIOL, V252, pG736, DOI 10.1152/ajpgi.1987.252.6.G736
   Conway G, 2014, EUR J ENDOCRINOL, V171, pP1, DOI 10.1530/EJE-14-0253
   Cote CD, 2014, J BIOL CHEM, V289, P11642, DOI 10.1074/jbc.O114.556068
   Covasa M, 2010, AM J PHYSIOL-REG I, V299, pR1423, DOI 10.1152/ajpregu.00126.2010
   CRAWLEY JN, 1983, NATURE, V302, P703, DOI 10.1038/302703a0
   CREUTZFELDT W, 1978, DIABETOLOGIA, V14, P15, DOI 10.1007/BF00429703
   Cummings DE, 2002, NEW ENGL J MED, V346, P1623, DOI 10.1056/NEJMoa012908
   Daghestani MH, 2011, EUR J OBSTET GYN R B, V155, P65, DOI 10.1016/j.ejogrb.2010.11.019
   Date Y, 2002, GASTROENTEROLOGY, V123, P1120, DOI 10.1053/gast.2002.35954
   Date Y, 2000, ENDOCRINOLOGY, V141, P4255, DOI 10.1210/en.141.11.4255
   Deacon CF, 2004, HORM METAB RES, V36, P761, DOI 10.1055/s-2004-826160
   Degen L, 2005, GASTROENTEROLOGY, V129, P1430, DOI 10.1053/j.gastro.2005.09.001
   Dockray GJ, 2014, J PHYSIOL-LONDON, V592, P2927, DOI 10.1113/jphysiol.2014.270850
   Duca FA, 2012, BRIT J NUTR, V108, P778, DOI 10.1017/S0007114512000529
   EBERLEIN GA, 1989, PEPTIDES, V10, P797, DOI 10.1016/0196-9781(89)90116-2
   ELAHI D, 1984, DIABETES, V33, P950, DOI 10.2337/diabetes.33.10.950
   Elkind-Hirsch K, 2008, J CLIN ENDOCR METAB, V93, P2670, DOI 10.1210/jc.2008-0115
   ELLIOTT RM, 1993, J ENDOCRINOL, V138, P159, DOI 10.1677/joe.0.1380159
   ELRICK H, 1964, J CLIN ENDOCR METAB, V24, P1076, DOI 10.1210/jcem-24-10-1076
   English PJ, 2002, J CLIN ENDOCR METAB, V87, P2984, DOI 10.1210/jc.87.6.2984
   Escobar-Morreale HF, 2005, J CLIN ENDOCR METAB, V90, P6364, DOI 10.1210/jc.2005-1490
   Feinle C, 2002, PEPTIDES, V23, P1491, DOI 10.1016/S0196-9781(02)00087-6
   Flint A, 2001, INT J OBESITY, V25, P781, DOI 10.1038/sj.ijo.0801627
   Munoz JSG, 2015, J PHYSIOL BIOCHEM, V71, P17, DOI 10.1007/s13105-014-0375-7
   Gama R, 1996, ANN CLIN BIOCHEM, V33, P190
   Gambineri A, 2003, J ENDOCRINOL INVEST, V26, P629, DOI 10.1007/BF03347020
   Gao T, 2016, ENDOCR J, V63, P93, DOI 10.1507/endocrj.EJ15-0318
   Gibbons C, 2016, PEPTIDES, V77, P3, DOI 10.1016/j.peptides.2015.09.010
   GIBBS J, 1973, J COMP PHYSIOL PSYCH, V84, P488, DOI 10.1037/h0034870
   GIBBS J, 1973, NATURE, V245, P323, DOI 10.1038/245323a0
   Gibson CD, 2010, J NEUROENDOCRINOL, V22, P833, DOI 10.1111/j.1365-2826.2010.02025.x
   Glintborg D, 2006, EUR J ENDOCRINOL, V155, P337, DOI 10.1530/eje.1.02207
   Guido M, 2007, FERTIL STERIL, V88, P125, DOI 10.1016/j.fertnstert.2006.11.067
   Hellstrom PM, 2004, BRIT J NUTR, V92, pS47, DOI 10.1079/BJN20041142
   HERRMANN C, 1995, DIGESTION, V56, P117, DOI 10.1159/000201231
   Hirschberg AL, 2004, GYNECOL ENDOCRINOL, V19, P79, DOI 10.1080/09513590400002300
   Holst JJ, 2007, PHYSIOL REV, V87, P1409, DOI 10.1152/physrev.00034.2006
   Houjeghani S, 2012, INT J FERTIL STERIL, V6, P117
   Japur CC, 2014, REPROD SCI, V21, P1020, DOI 10.1177/1933719114522521
   Jensterle M, 2015, ENDOCR RES, V40, P133, DOI 10.3109/07435800.2014.966385
   Kahal H, 2015, BMC ENDOCR DISORD, V15, DOI 10.1186/s12902-015-0005-6
   Karamanakos SN, 2008, ANN SURG, V247, P401, DOI 10.1097/SLA.0b013e318156f012
   Kastin AJ, 2002, J MOL NEUROSCI, V18, P7, DOI 10.1385/JMN:18:1-2:07
   Kelley ST, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0146509
   KENNEDY GC, 1953, PROC R SOC SER B-BIO, V140, P578, DOI 10.1098/rspb.1953.0009
   KIEFFER TJ, 1995, ENDOCRINOLOGY, V136, P3585, DOI 10.1210/en.136.8.3585
   KISSILEFF HR, 1981, AM J CLIN NUTR, V34, P154, DOI 10.1093/ajcn/34.2.154
   Knop FK, 2012, DIABETES OBES METAB, V14, P500, DOI 10.1111/j.1463-1326.2011.01549.x
   Kopin AS, 1999, J CLIN INVEST, V103, P383, DOI 10.1172/JCI4901
   Korner J, 2005, J CLIN ENDOCR METAB, V90, P359, DOI 10.1210/jc.2004-1076
   Kos-Kudla B, 2006, NEUROENDOCRINOL LETT, V27, P763
   Kuo YT, 2007, J NEUROSCI, V27, P12341, DOI 10.1523/JNEUROSCI.2391-07.2007
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   le Roux CW, 2006, ENDOCRINOLOGY, V147, P3, DOI 10.1210/en.2005-0972
   le Roux CW, 2006, ANN SURG, V243, P108, DOI 10.1097/01.sla.0000183349.16877.84
   Lee WJ, 2011, SURG OBES RELAT DIS, V7, P683, DOI 10.1016/j.soard.2011.07.009
   Ley RE, 2006, NATURE, V444, P1022, DOI 10.1038/4441022a
   LIDDLE RA, 1985, J CLIN INVEST, V75, P1144, DOI 10.1172/JCI111809
   Lin HC, 2000, PEPTIDES, V21, P1561, DOI 10.1016/S0196-9781(00)00312-0
   Lin TC, 2015, HUM REPROD, V30, P2639, DOI 10.1093/humrep/dev231
   Lutter M, 2009, J NUTR, V139, P629, DOI 10.3945/jn.108.097618
   Ma J, 2014, ENDOCRINE, V47, P668, DOI 10.1007/s12020-014-0275-1
   Mahde Atheer, 2009, Oman Med J, V24, P108, DOI 10.5001/omj.2009.25
   Major P, 2015, VIDEOSURGERY MINIINV, V10, P458, DOI 10.5114/wiitm.2015.54003
   Majuri A, 2007, EUR J ENDOCRINOL, V156, P263, DOI 10.1530/eje.1.02331
   Malik S, 2008, CELL METAB, V7, P400, DOI 10.1016/j.cmet.2008.03.007
   Malin SK, 2014, INT J OBESITY, V38, P364, DOI 10.1038/ijo.2013.196
   Marsh CA, 2013, FERTIL STERIL, V100, P200, DOI 10.1016/j.fertnstert.2013.02.054
   Martins C, 2011, OBES SURG, V21, P751, DOI 10.1007/s11695-011-0399-9
   Matson CA, 1999, AM J PHYSIOL-REG I, V276, pR1038, DOI 10.1152/ajpregu.1999.276.4.R1038
   Menzies J, 2012, J NEUROENDOCRINOL, V24, P1272, DOI 10.1111/j.1365-2826.2012.02344.x
   Merchenthaler I, 1999, J COMP NEUROL, V403, P261, DOI 10.1002/(SICI)1096-9861(19990111)403:2<261::AID-CNE8>3.0.CO;2-5
   Micic D, 2007, J ENDOCRINOL INVEST, V30, P820, DOI 10.1007/BF03349222
   Mitkov M, 2008, GYNECOL ENDOCRINOL, V24, P625, DOI 10.1080/09513590802302233
   Moran LJ, 2007, AM J CLIN NUTR, V86, P1603
   Moran LJ, 2009, FERTIL STERIL, V92, P1966, DOI 10.1016/j.fertnstert.2008.09.018
   Moran LJ, 2004, J CLIN ENDOCR METAB, V89, P3337, DOI 10.1210/jc.2003-031583
   Moran TH, 2004, AM J PHYSIOL-GASTR L, V286, pG183, DOI 10.1152/ajpgi.00434.2003
   Morton GJ, 2014, NAT REV NEUROSCI, V15, P367, DOI 10.1038/nrn3745
   Muscelli E, 2008, DIABETES, V57, P1340, DOI 10.2337/db07-1315
   Naessen S, 2006, GYNECOL ENDOCRINOL, V22, P388, DOI 10.1080/09513590600847421
   Nakazato M, 2001, NATURE, V409, P194, DOI 10.1038/35051587
   NAUCK MA, 1993, J CLIN INVEST, V91, P301, DOI 10.1172/JCI116186
   Nauck MA, 1997, AM J PHYSIOL-ENDOC M, V273, pE981, DOI 10.1152/ajpendo.1997.273.5.E981
   Nayak UA, 2010, QJM-INT J MED, V103, P687, DOI 10.1093/qjmed/hcq112
   Orio F, 2003, J CLIN ENDOCR METAB, V88, P942, DOI 10.1210/jc.2002-021451
   Ottman N, 2012, FRONT CELL INFECT MI, V2, DOI 10.3389/fcimb.2012.00104
   Owyang C, 2011, J NEUROGASTROENTEROL, V17, P338, DOI 10.5056/jnm.2011.17.4.338
   Pagotto U, 2002, J CLIN ENDOCR METAB, V87, P5625, DOI 10.1210/jc.2002-020776
   Panidis D, 2005, HUM REPROD, V20, P2127, DOI 10.1093/humrep/dei055
   Panidis D, 2010, EUR J OBSTET GYN R B, V149, P170, DOI 10.1016/j.ejogrb.2009.12.019
   Park JS, 2013, PEDIATR GASTROENTERO, V16, P22, DOI 10.5223/pghn.2013.16.1.22
   Peterli R, 2012, OBES SURG, V22, P740, DOI 10.1007/s11695-012-0622-3
   Phillips LK, 2011, ANN NY ACAD SCI, V1243, P1, DOI 10.1111/j.1749-6632.2012.06491.x
   POLAK JM, 1973, GUT, V14, P284, DOI 10.1136/gut.14.4.284
   Pontikis C, 2011, J WOMENS HEALTH, V20, P971, DOI 10.1089/jwh.2010.2272
   Ranganath LR, 1996, GUT, V38, P916, DOI 10.1136/gut.38.6.916
   Rasmussen CB, 2014, FRONT ENDOCRINOL, V5, DOI 10.3389/fendo.2014.00140
   Rassi A, 2010, COMPR PSYCHIAT, V51, P599, DOI 10.1016/j.comppsych.2010.02.009
   Rehfeld JF, 2001, J CLIN ENDOCR METAB, V86, P251, DOI 10.1210/jc.86.1.251
   Rocca AS, 1999, ENDOCRINOLOGY, V140, P1687, DOI 10.1210/en.140.4.1687
   Sadry SA, 2013, NAT REV ENDOCRINOL, V9, P425, DOI 10.1038/nrendo.2013.47
   Sagsoz N, 2009, FERTIL STERIL, V92, P660, DOI 10.1016/j.fertnstert.2008.07.008
   SALERA M, 1982, J CLIN ENDOCR METAB, V55, P329, DOI 10.1210/jcem-55-2-329
   Santo MA, 2016, OBES SURG, V26, P919, DOI 10.1007/s11695-015-1908-z
   Scharf MT, 2004, SEMIN LIVER DIS, V24, P335, DOI 10.1055/s-2004-860863
   Schofl C, 2002, J CLIN ENDOCR METAB, V87, P4607, DOI 10.1210/jc.2002-020505
   Sever MJ, 2014, EUR J ENDOCRINOL, V170, P451, DOI 10.1530/EJE-13-0797
   Shah M, 2014, REV ENDOCR METAB DIS, V15, P181, DOI 10.1007/s11154-014-9289-5
   Shaker Mahmud, 2010, Oman Med J, V25, P289, DOI 10.5001/omj.2010.84
   Shiiya T, 2002, J CLIN ENDOCR METAB, V87, P240, DOI 10.1210/jc.87.1.240
   Shughrue PJ, 1996, ENDOCRINOLOGY, V137, P5159, DOI 10.1210/en.137.11.5159
   Simon GE, 2006, ARCH GEN PSYCHIAT, V63, P824, DOI 10.1001/archpsyc.63.7.824
   Skubleny D, 2016, OBES SURG, V26, P169, DOI 10.1007/s11695-015-1902-5
   Crespo CS, 2014, FRONT ENDOCRINOL, V5, DOI 10.3389/fendo.2014.00058
   Stoeckel LE, 2008, NEUROIMAGE, V41, P636, DOI 10.1016/j.neuroimage.2008.02.031
   Svendsen PF, 2009, METABOLISM, V58, P586, DOI 10.1016/j.metabol.2008.11.009
   Swartz TD, 2010, J NUTR, V140, P1698, DOI 10.3945/jn.110.124149
   Tamboli RA, 2014, OBESITY, V22, P1617, DOI 10.1002/oby.20776
   Tang-Christensen M, 2001, INT J OBESITY, V25, pS42, DOI 10.1038/sj.ijo.0801912
   TATEMOTO K, 1980, NATURE, V285, P417, DOI 10.1038/285417a0
   Tremellen K, 2012, MED HYPOTHESES, V79, P104, DOI 10.1016/j.mehy.2012.04.016
   Tschop M, 2001, DIABETES, V50, P707, DOI 10.2337/diabetes.50.4.707
   Tsilchorozidou T, 2008, CLIN ENDOCRINOL, V69, P936, DOI 10.1111/j.1365-2265.2008.03285.x
   USDIN TB, 1993, ENDOCRINOLOGY, V133, P2861, DOI 10.1210/en.133.6.2861
   Vahl TP, 2007, ENDOCRINOLOGY, V148, P4965, DOI 10.1210/en.2006-0153
   van Bloemendaal L, 2014, J ENDOCRINOL, V221, pT1, DOI 10.1530/JOE-13-0414
   Van Vugt DA, 2014, BRAIN RES, V1558, P44, DOI 10.1016/j.brainres.2014.02.037
   Van Vugt DA, 2013, OBESITY, V21, P1215, DOI 10.1002/oby.20148
   Verdich C, 2001, INT J OBESITY, V25, P1206, DOI 10.1038/sj.ijo.0801655
   Verdich C, 2001, J CLIN ENDOCR METAB, V86, P4382, DOI 10.1210/jc.86.9.4382
   Vidal J, 2009, J CLIN ENDOCR METAB, V94, P884, DOI 10.1210/jc.2008-1620
   Vilsboll T, 2012, BMJ-BRIT MED J, V344, DOI 10.1136/bmj.d7771
   Vozzo R, 2002, METABOLISM, V51, P949, DOI 10.1053/meta.2002.34012
   Vrbikova J, 2008, EUR J ENDOCRINOL, V159, P121, DOI 10.1530/EJE-08-0097
   Wasko R, 2004, HORM METAB RES, V36, P170, DOI 10.1055/s-2004-814341
   WEST DB, 1984, AM J PHYSIOL, V246, pR776, DOI 10.1152/ajpregu.1984.246.5.R776
   Whitman WB, 1998, P NATL ACAD SCI USA, V95, P6578, DOI 10.1073/pnas.95.12.6578
   Wren AM, 2001, J CLIN ENDOCR METAB, V86, P5992, DOI 10.1210/jc.86.12.5992
   Yildiz BO, 2013, WOMENS HEALTH, V9, P505, DOI [10.2217/WHE.13.53, 10.2217/whe.13.53]
   Yildiz BO, 2012, HUM REPROD, V27, P3067, DOI 10.1093/humrep/des232
   Yousseif A, 2014, OBES SURG, V24, P241, DOI 10.1007/s11695-013-1066-0
   Zwirska-Korczala K, 2008, J PHYSIOL PHARMACOL, V59, P161
   Zwirska-Korczala K, 2007, J PHYSIOL PHARMACOL, V58, P13
NR 176
TC 13
Z9 21
U1 3
U2 44
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PY 2016
VL 22
IS 36
BP 5572
EP 5587
DI 10.2174/1381612822666160715143933
PG 16
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA ED0FR
UT WOS:000388518900009
PM 27426125
DA 2023-06-08
ER

PT J
AU Balakumar, M
   Prabhu, D
   Sathishkumar, C
   Prabu, P
   Rokana, N
   Kumar, R
   Raghavan, S
   Soundarajan, A
   Grover, S
   Batish, VK
   Mohan, V
   Balasubramanyam, M
AF Balakumar, Mahalingam
   Prabhu, Durai
   Sathishkumar, Chandrakumar
   Prabu, Paramasivam
   Rokana, Namita
   Kumar, Ramesh
   Raghavan, Srividhya
   Soundarajan, Avinash
   Grover, Sunita
   Batish, Virender Kumar
   Mohan, Viswanathan
   Balasubramanyam, Muthuswamy
TI Improvement in glucose tolerance and insulin sensitivity by probiotic
   strains of Indian gut origin in high-fat diet-fed C57BL/6J mice
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Article
DE Type 2 diabetes; Insulin resistance; Probiotics; High-fat diet; Tight
   junction protein; LPS; Lactobacillus plantarum MTCC 5690; Lactobacillus
   fermentum MTCC 5689; LGG
ID LACTOBACILLUS-PLANTARUM LP91; INDUCED OBESITY; ER STRESS; CELL FUNCTION;
   LIPID LEVELS; FED RATS; MICROBIOTA; RESISTANCE; CASEI; PREBIOTICS
AB Purpose Diabetes and obesity are characterized by glucose intolerance, fat deposition, inflammation, and dyslipidemia. Recent reports postulated that distinct gut microbiota alterations were observed in obese/diabetic subjects and modulating gut microbiota beneficially through specific probiotics could be a potential therapeutic option for type 2 diabetes/obesity. Therefore, we attempted to study the efficacy of probiotics of Indian gut origin (Lactobacillus plantarum MTCC5690 and Lactobacillus fermentum MTCC5689) along with a positive control, Lactobacillus rhamnosus (LGG) on glucose/lipid homeostasis in high-fat-diet-induced diabetic animal model.
   Methods C57BL/6J male mice were divided into seven groups (n = 6 per group) comprising feeding on: (1) Normal Pellet Diet (NPD), (2) High-Fat Diet (HFD), (3) HFD with LGG, (4) HFD with MTCC5690, (5) HFD with MTCC5689, (6) HFD with metformin, and 7) HFD with vildagliptin for a period of 6 months. Biochemical markers, glucose tolerance, insulin resistance, and GLP-1 and LPS levels were assessed by standard protocols. Gut integrity was measured by intestinal permeability test. Transcriptional levels of tight junction proteins (TJPs) were probed in small intestinal tissues while inflammatory signals and other pathway specific genes were profiled in liver, visceral adipose tissue, and skeletal muscle.
   Results Mice fed with HFD became insulin resistant, glucose intolerant, hyperglycemic, and dyslipidemic. Diabetic mice were characterized to exhibit decreased levels of GLP-1, increased gut permeability, increased circulatory levels of LPS, decrease in the gene expression patterns of intestinal tight junction markers (occludin and ZO-1), and increased proinflammatory gene markers (TNF alpha and IL6) in visceral fat along with decreased mRNA expression of FIAF and adiponectin. Diabetic mice also exhibited increased mRNA expression of ER stress markers in skeletal muscle. In addition, liver from HFD-fed diabetic mice showed increased gene expressions of proinflammation, lipogenesis, and gluconeogenesis. Probiotic interventions (most prominently the MTCC5689) resisted insulin resistance and development of diabetes in mice under HFD feeding and beneficially modulated all the biochemical and molecular alterations in a mechanistic way in several tissues. The metabolic benefits offered by the probiotics were also more or less similar to that of standard drugs such as metformin and vildagliptin.
   Conclusion Native probiotic strains MTCC 5690 and MTCC 5689 appear to have potential against insulin resistance and type 2 diabetes with mechanistic, multiple tissue-specific mode of actions.
C1 [Balakumar, Mahalingam; Prabhu, Durai; Sathishkumar, Chandrakumar; Prabu, Paramasivam; Kumar, Ramesh; Raghavan, Srividhya; Soundarajan, Avinash; Mohan, Viswanathan; Balasubramanyam, Muthuswamy] Madras Diabet Res Fdn, Dept Cell & Mol Biol, Dr Rema Mohan High Throughput Screening HTS Lab, 4 Conran Smith Rd, Madras 600086, Tamil Nadu, India.
   [Balakumar, Mahalingam; Prabhu, Durai; Sathishkumar, Chandrakumar; Prabu, Paramasivam; Kumar, Ramesh; Raghavan, Srividhya; Soundarajan, Avinash; Mohan, Viswanathan; Balasubramanyam, Muthuswamy] Dr Mohans Diabet Specialties Ctr, 4 Conran Smith Rd, Madras 600086, Tamil Nadu, India.
   [Rokana, Namita; Grover, Sunita; Batish, Virender Kumar] NDRI, Karnal 132001, Haryana, India.
C3 Madras Diabetes Research Foundation; Indian Council of Agricultural
   Research (ICAR); ICAR - National Dairy Research Institute
RP Balasubramanyam, M (通讯作者)，Madras Diabet Res Fdn, Dept Cell & Mol Biol, Dr Rema Mohan High Throughput Screening HTS Lab, 4 Conran Smith Rd, Madras 600086, Tamil Nadu, India.; Balasubramanyam, M (通讯作者)，Dr Mohans Diabet Specialties Ctr, 4 Conran Smith Rd, Madras 600086, Tamil Nadu, India.
EM balusignal@gmail.com
RI Gnanavadivel, Rameshkumar/HZJ-7192-2023; Varadharajan, Ramesh
   kumar/B-4553-2011; Paramasivam, Prabu/AAT-4515-2020; Rokana,
   Namita/N-6761-2019; Chandrakumar, Sathishkumar/AAM-3149-2020
OI Varadharajan, Ramesh kumar/0000-0002-0310-1953; Rokana,
   Namita/0000-0003-1057-9944; Chandrakumar,
   Sathishkumar/0000-0003-2320-050X; Prabu,
   Paramasivam/0000-0002-8626-1601; Soundararajan,
   Avinash/0000-0001-9557-0038
FU Department of Biotechnology (DBT, New Delhi, Government of India)
FX Financial assistance from Department of Biotechnology (DBT, New Delhi,
   Government of India) is greatly acknowledged. BM acknowledges Council of
   Scientific and Industrial Research (CSIR), New Delhi for Research
   Associateship.
CR Amar J, 2011, EMBO MOL MED, V3, P559, DOI 10.1002/emmm.201100159
   Anjana RM, 2011, DIABETOLOGIA, V54, P3022, DOI 10.1007/s00125-011-2291-5
   Aronsson L, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0013087
   Backhed F, 2007, P NATL ACAD SCI USA, V104, P979, DOI 10.1073/pnas.0605374104
   Balasubramanyam M, 2011, MOL CELL BIOCHEM, V351, P197, DOI 10.1007/s11010-011-0727-3
   Bleau C, 2015, DIABETES-METAB RES, V31, P545, DOI 10.1002/dmrr.2617
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   Cani PD, 2009, AM J CLIN NUTR, V90, P1236, DOI 10.3945/ajcn.2009.28095
   Chandran A, 2013, MICROBIOL RES, V168, P555, DOI 10.1016/j.micres.2013.04.010
   Chauhan R, 2014, BIOMED RES INT, V2014, DOI 10.1155/2014/206732
   Corcos M, 2003, PSYCHONEUROENDOCRINO, V28, P229, DOI 10.1016/S0306-4530(02)00021-5
   D'Alessio DA, 2009, J CLIN ENDOCR METAB, V94, P81, DOI 10.1210/jc.2008-1135
   Duary RK, 2012, MOL BIOL REP, V39, P4765, DOI 10.1007/s11033-011-1269-1
   Duary Raj Kumar, 2011, Indian J Med Res, V134, P664, DOI 10.4103/0971-5916.90992
   Everard A, 2013, BEST PRACT RES CL GA, V27, P73, DOI 10.1016/j.bpg.2013.03.007
   Firouzi S, 2017, EUR J NUTR, V56, P1535, DOI 10.1007/s00394-016-1199-8
   Flamment M, 2012, TRENDS ENDOCRIN MET, V23, P381, DOI 10.1016/j.tem.2012.06.003
   Food and Agricultural Organisation/World Health Organisation (FAO/WHO), 2002, WORK GROUP REP DRAFT
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Grover S, 2013, GENOME ANNOUNCEMENTS, V1, DOI 10.1128/genomeA.00976-13
   Grover S, 2013, GENOME ANNOUNCEMENTS, V1, DOI 10.1128/genomeA.00883-13
   Hsieh FC, 2013, NUTR METAB, V10, DOI 10.1186/1743-7075-10-35
   Jayashree B, 2014, MOL CELL BIOCHEM, V388, P203, DOI 10.1007/s11010-013-1911-4
   Saez-Lara MJ, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17060928
   Kadooka Y, 2010, EUR J CLIN NUTR, V64, P636, DOI 10.1038/ejcn.2010.19
   Kaji I, 2011, J MOL HISTOL, V42, P27, DOI 10.1007/s10735-010-9304-4
   Karaki S, 2006, CELL TISSUE RES, V324, P353, DOI 10.1007/s00441-005-0140-x
   Karimi G, 2015, FOOD NUTR RES, V59, DOI 10.3402/fnr.v59.29273
   Kim KA, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0047713
   Kim SW, 2013, BIOCHEM BIOPH RES CO, V431, P258, DOI 10.1016/j.bbrc.2012.12.121
   Kumar R, 2011, BRIT J NUTR, V105, P561, DOI 10.1017/S0007114510003740
   Lenin R, 2015, J LEUKOCYTE BIOL, V98, P615, DOI 10.1189/jlb.3A1214-609R
   Lim GE, 2009, ENDOCRINOLOGY, V150, P580, DOI 10.1210/en.2008-0726
   Mandard S, 2006, J BIOL CHEM, V281, P934, DOI 10.1074/jbc.M506519200
   Mannucci E, 2004, DIABETES NUTR METAB, V17, P336
   Matsuzaki T, 1997, APMIS, V105, P643, DOI 10.1111/j.1699-0463.1997.tb05066.x
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Mohan V, 2007, FORUM NUTR, V60, P118, DOI 10.1159/000107088
   Naito E, 2011, J APPL MICROBIOL, V110, P650, DOI 10.1111/j.1365-2672.2010.04922.x
   Ooi LG, 2010, INT J MOL SCI, V11, P2499, DOI 10.3390/ijms11062499
   Park KY, 2015, J CLIN BIOCHEM NUTR, V56, P240, DOI 10.3164/jcbn.14-116
   Pereira DIA, 2002, CRIT REV BIOCHEM MOL, V37, P259, DOI 10.1080/10409230290771519
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Rajkumar H, 2015, J CARDIOVASC PHARM T, V20, P289, DOI 10.1177/1074248414555004
   Shen J, 2013, MOL ASPECTS MED, V34, P39, DOI 10.1016/j.mam.2012.11.001
   Simon MC, 2015, DIABETES CARE, V38, P1827, DOI 10.2337/dc14-2690
   Srinivasan K, 2004, METHOD FIND EXP CLIN, V26, P327, DOI 10.1358/mf.2004.26.5.831322
   Stenman LK, 2015, DIABETOL METAB SYNDR, V7, DOI 10.1186/s13098-015-0075-7
   Sudhakaran VA, 2013, GENES NUTR, V8, P637, DOI 10.1007/s12263-013-0347-5
   Sun J, 2016, BRIT J NUTR, V115, P1167, DOI 10.1017/S0007114516000076
   Tonucci LB, 2017, CLIN NUTR, V36, P85, DOI 10.1016/j.clnu.2015.11.011
   Wang Q, 2001, AM J PHYSIOL-REG I, V281, P23
   Whiting MJ, 1997, DIABETES CARE, V20, P12, DOI 10.2337/diacare.20.1.12
   Wong JMW, 2006, J CLIN GASTROENTEROL, V40, P235, DOI 10.1097/00004836-200603000-00015
   Yadav H, 2007, NUTRITION, V23, P62, DOI 10.1016/j.nut.2006.09.002
   Yoo SR, 2013, OBESITY, V21, P2571, DOI 10.1002/oby.20428
   Zhang JQ, 1997, CHIN J ENDOCRINOL ME, V13, P77
NR 58
TC 95
Z9 108
U1 4
U2 83
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD FEB
PY 2018
VL 57
IS 1
BP 279
EP 295
DI 10.1007/s00394-016-1317-7
PG 17
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA FX0KU
UT WOS:000425733500023
PM 27757592
DA 2023-06-08
ER

PT J
AU Kim, T
   Holleman, C
   Ptacek, T
   Morrow, C
   Habegger, K
AF Kim, T.
   Holleman, Cl
   Ptacek, T.
   Morrow, Cd
   Habegger, Km
TI Duodenal endoluminal barrier sleeve alters gut microbiota of ZDF rats
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Article
ID INTESTINAL MICROBIOTA; GASTRIC BYPASS; WEIGHT-LOSS; HIGH-FAT; OBESITY;
   DIET; DYSBIOSIS; SEQUENCES; COMMUNITY; BACTERIA
AB BACKGROUND/OBJECTIVES: The combination of energy dense diets and reduced energy expenditure in modern society has escalated the prevalence of obesity and obesity-related comorbidities. Among these disease states, type-2 diabetics (T2D) are disproportionately associated with obesity, suggesting a shared etiology. In conjunction with defects in hormonal and inflammatory states, obesity and T2D are also characterized by dysbiosis.
   METHODS: We have recently described the beneficial effects of duodenal nutrient exclusion, as induced by the duodenal endoluminal sleeve (DES); including body weight loss, prevented fat mass accumulation, and improved glucose tolerance in the ZDF rat, a rodent model of obesity and type-2 diabetes (T2D). To assess the relative role of DES on hindgut microbiota in the context of these metabolic changes, we analyzed cecal samples from rats implanted with a duodenal endoluminal sleeve (DES), or a sham control of this procedure. A group of pair-fed (pf) sham controls was also included to account for changes induced by reduced body weight and food intake.
   RESULTS: Analysis of hindgut microbiota following DES in the ZDF rat elucidated discrete changes in several microbial populations including a reduction in Paraprevotella family members of the Clostridiales order along with an increase in Akkermansia muciniphila and species of the Allobaculum and Bifidobacterium genera.
   CONCLUSIONS: Altogether, these observations suggest that like Roux-en Y gastric bypass (RYGB) and Metformin, regulation of gut microbiota may be a contributing factor to the therapeutic effects of DES.
C1 [Kim, T.; Holleman, Cl; Habegger, Km] Univ Alabama Birmingham, Dept Med Endocrinol, Diabetes & Metabolism, Comprehensive Diabetes Ctr, Birmingham, AL 35487 USA.
   [Ptacek, T.] Univ Alabama Birmingham, Ctr Clin & Translat Sci, Birmingham, AL 35487 USA.
   [Ptacek, T.; Morrow, Cd] Univ Alabama Birmingham, Dept Microbiol, Birmingham, AL 35487 USA.
   [Morrow, Cd] Univ Alabama Birmingham, Dept Cell Develop & Integrative Biol, Birmingham, AL 35487 USA.
C3 University of Alabama System; University of Alabama Birmingham;
   University of Alabama System; University of Alabama Birmingham;
   University of Alabama System; University of Alabama Birmingham;
   University of Alabama System; University of Alabama Birmingham
RP Habegger, K (通讯作者)，Univ Alabama Birmingham, Dept Med Endocrinol, Diabetes & Metabolism, Comprehensive Diabetes Ctr, Birmingham, AL 35487 USA.
EM habegger@uab.edu
OI Kim, Teayoun/0000-0003-4664-6803; Habegger, Kirk/0000-0002-0342-5480
FU National Institute Of Diabetes And Digestive And Kidney Diseases
   [5K01DK098319]; Microbiome Resource at the University of Alabama at
   Birmingham: School of Medicine, Comprehensive Cancer Center
   [P30AR050948]; Center for AIDS Research [5P30AI027767]; Center for
   Clinical Translational Science [UL1TR000165]; Heflin Center
FX We thank Peter Eipers for sample processing and 16S analysis. The
   project described was supported by Award Number 5K01DK098319 (KMH) from
   the National Institute Of Diabetes And Digestive And Kidney Diseases.
   The following are acknowledged for their support of the Microbiome
   Resource at the University of Alabama at Birmingham: School of Medicine,
   Comprehensive Cancer Center (P30AR050948), Center for AIDS Research
   (5P30AI027767), Center for Clinical Translational Science (UL1TR000165)
   and Heflin Center.
CR Anhe FF, 2015, CURR OBES REP, V4, P389, DOI 10.1007/s13679-015-0172-9
   Brawner KM, 2014, CANCER J, V20, P211, DOI 10.1097/PPO.0000000000000043
   Brown K, 2012, NUTRIENTS, V4, P1095, DOI [10.3390/nu4081095, 10.3390/nu4111552]
   Cani PD, 2007, DIABETOLOGIA, V50, P2374, DOI 10.1007/s00125-007-0791-0
   Caporaso JG, 2010, BIOINFORMATICS, V26, P266, DOI 10.1093/bioinformatics/btp636
   Cox LM, 2015, NAT REV ENDOCRINOL, V11, P182, DOI 10.1038/nrendo.2014.210
   Cummings BP, 2013, DIS MODEL MECH, V6, P443, DOI 10.1242/dmm.010421
   Dao MC, 2016, GUT, V65, P426, DOI 10.1136/gutjnl-2014-308778
   Dore J, 2013, UNITED EUR GASTROENT, V1, P311, DOI 10.1177/2050640613502477
   Edgar RC, 2010, BIOINFORMATICS, V26, P2460, DOI 10.1093/bioinformatics/btq461
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Furet JP, 2010, DIABETES, V59, P3049, DOI 10.2337/db10-0253
   Ganesh BP, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0074963
   Guo Y, 2017, DIABETES-METAB RES, V33, DOI 10.1002/dmrr.2857
   Habegger KM, 2014, GUT, V63, P1238, DOI 10.1136/gutjnl-2013-304583
   Hartstra AV, 2015, DIABETES CARE, V38, P159, DOI 10.2337/dc14-0769
   HATHEWAY CL, 1990, CLIN MICROBIOL REV, V3, P66, DOI 10.1128/CMR.3.1.66-98.1990
   Kong LC, 2013, AM J CLIN NUTR, V98, P16, DOI 10.3945/ajcn.113.058743
   Kozich JJ, 2013, APPL ENVIRON MICROB, V79, P5112, DOI 10.1128/AEM.01043-13
   Kumar R., 2014, CURR PROTOC HUM GENE, V82, p18.8.1, DOI [10.1002/0471142905.hg1808s82, DOI 10.1002/0471142905.HG1808S82]
   Kumar R, 2016, BMC MICROBIOL, V16, DOI 10.1186/s12866-015-0622-2
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Liou AP, 2013, SCI TRANSL MED, V5, DOI 10.1126/scitranslmed.3005687
   Lozupone C, 2006, BMC BIOINFORMATICS, V7, DOI 10.1186/1471-2105-7-371
   McDonald D, 2012, ISME J, V6, P610, DOI 10.1038/ismej.2011.139
   Murri M, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-46
   Nagao-Kitamoto H, 2016, INTEST RES, V14, P127, DOI 10.5217/ir.2016.14.2.127
   Parks BW, 2013, CELL METAB, V17, P141, DOI 10.1016/j.cmet.2012.12.007
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Ravussin Y, 2012, OBESITY, V20, P738, DOI 10.1038/oby.2011.111
   Rios-Covian D, 2016, FRONT MICROBIOL, V7, DOI 10.3389/fmicb.2016.00185
   Ryan KK, 2014, NATURE, V509, P183, DOI 10.1038/nature13135
   Sabate JM, 2016, OBES SURG
   Smith KB, 2016, PRIMARY CARE, V43, P121, DOI 10.1016/j.pop.2015.10.001
   Tremaroli V, 2015, CELL METAB, V22, P228, DOI 10.1016/j.cmet.2015.07.009
   Turnbaugh PJ, 2009, NATURE, V457, P480, DOI 10.1038/nature07540
   Wang Q, 2007, APPL ENVIRON MICROB, V73, P5261, DOI 10.1128/AEM.00062-07
   Wen L, 2008, NATURE, V455, P1109, DOI 10.1038/nature07336
   Zhang HS, 2009, P NATL ACAD SCI USA, V106, P2365, DOI 10.1073/pnas.0812600106
   Zuo HJ, 2011, WORLD J GASTROENTERO, V17, P1076, DOI 10.3748/wjg.v17.i8.1076
NR 40
TC 11
Z9 11
U1 0
U2 5
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0307-0565
EI 1476-5497
J9 INT J OBESITY
JI Int. J. Obes.
PD MAR
PY 2017
VL 41
IS 3
BP 381
EP 389
DI 10.1038/ijo.2016.224
PG 9
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA EN2CC
UT WOS:000395816000004
PM 27924082
OA Green Accepted
DA 2023-06-08
ER

PT J
AU Deng, ZZ
   Wu, N
   Wang, J
   Geng, LH
   Yue, Y
   Wang, FH
   Zhang, QB
AF Deng, Zhenzhen
   Wu, Ning
   Wang, Jing
   Geng, Lihua
   Yue, Yang
   Wang, Fahe
   Zhang, Quanbin
TI Low molecular weight fucoidan fraction LF2 improves metabolic syndrome
   via up-regulating PI3K-AKT-mTOR axis and increasing the abundance of
   Akkermansia muciniphila in the gut microbiota
SO INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
LA English
DT Article
DE Fucoidan; Metabolic syndrome; Gut microbiota
ID DIET-INDUCED DYSLIPIDEMIA; DIABETIC-NEPHROPATHY; INSULIN-RESISTANCE;
   MOUSE MODEL; OBESITY; LIVER; INFLAMMATION; MICE; ASSOCIATION; STEATOSIS
AB Metabolic syndrome (MetS) is a pathological condition of a variety of metabolic abnormalities, which requires more urgent treatment and intervention. Fucoidan has been recommended as a supplement for health enhancement and disease management. Here, we first propose that the beneficial effect of low molecular weight fucoidan fraction LF2 in regulating metabolic syndrome induced by high-fat diet is similar to that of metformin, in terms of molecular mechanism and gut microbiota. The study found that LF2 significantly reduces fasting blood glucose, enhances insulin sensitivity and restores insulin homeostasis and lipid homeostasis. Moreover, LF2 reduced liver oxidative stress and inflammation, and improved hepatocyte steatosis. To decipher the mechanism behind this therapeutic effect, both the molecular mechanisms and gut microbiota were further analyzed. LF2 inhibited the activation of PI3K-Akt-mTOR axis and decreased the expression of SREBP-1c and PPAR gamma in liver. Interestingly, we found that LF2 and metformin have similar effects on gut microbiota, increasing the proportion of Verrucomicrobia and enriching the abundance of Akkermansia muciniphila, which is beneficial to host health. Collectively, our research clarifies the new application of fucoidan as a functional food for anti-MetS, and provides a new insight for fucoidan to exert systemic therapeutic effects from the perspective of molecular mechanism and gut microbiota.
C1 [Deng, Zhenzhen; Wu, Ning; Wang, Jing; Geng, Lihua; Yue, Yang; Zhang, Quanbin] Chinese Acad Sci, Inst Oceanol, CAS & Shandong Prov Key Lab Expt Marine Biol, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China.
   [Deng, Zhenzhen; Wu, Ning; Wang, Jing; Geng, Lihua; Yue, Yang; Zhang, Quanbin] Qingdao Natl Lab Marine Sci & Tech, Lab Marine Biol & Biotechnol, Qingdao 266071, Peoples R China.
   [Deng, Zhenzhen; Zhang, Quanbin] Univ Chinese Acad Sci, Beijing 100049, Peoples R China.
   [Wang, Fahe] Qingdao Brightmoon Seaweed Grp Co Ltd, State Key Lab Bioact Seaweed Subst, Qingdao, Peoples R China.
C3 Chinese Academy of Sciences; Institute of Oceanology, CAS; Laoshan
   Laboratory; Chinese Academy of Sciences; University of Chinese Academy
   of Sciences, CAS
RP Zhang, QB (通讯作者)，Chinese Acad Sci, Inst Oceanol, CAS & Shandong Prov Key Lab Expt Marine Biol, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China.
EM qbzhang@qdio.ac.cn
FU Major Scientific & Engineering Projects of Innovation in Shandong
   Province [2019JZZY010818]; National Natural Science Fundation of China
   [42176137]; STS project of the Chinese Academy of Sciences
   [KFJSTS-QYZD-195]; Special Open Fund of Laboratory for Marine Biology
   and Biotechnology, Qingdao Pilot National Laboratory for Marine Science
   and Technology [OF2020NO02]; K.C. Wong Education Foundation, CAS
FX The research was supported by the Major Scientific & Engineering
   Projects of Innovation in Shandong Province (Grant No. 2019JZZY010818);
   National Natural Science Fundation of China (Grand No. 42176137), STS
   project of the Chinese Academy of Sciences (KFJSTS-QYZD-195), the
   Special Open Fund of Laboratory for Marine Biology and Biotechnology,
   Qingdao Pilot National Laboratory for Marine Science and Technology (No.
   OF2020NO02); and K.C. Wong Education Foundation, CAS.
CR Aggarwal BB, 2010, ANNU REV NUTR, V30, P173, DOI 10.1146/annurev.nutr.012809.104755
   Allen L, 2017, J NUTR BIOCHEM, V48, P128, DOI 10.1016/j.jnutbio.2017.07.003
   Baxter NT, 2019, MBIO, V10, DOI [10.1128/mBio.02566-18, 10.1128/mbio.02566-18]
   Cardona F, 2013, J NUTR BIOCHEM, V24, P1415, DOI 10.1016/j.jnutbio.2013.05.001
   Chen HH, 2019, J AGR FOOD CHEM, V67, P5278, DOI 10.1021/acs.jafc.9b01192
   Chen QC, 2019, NUTRITION, V65, P50, DOI 10.1016/j.nut.2019.03.001
   Cheng Y, 2019, INT J BIOL MACROMOL, V131, P1162, DOI 10.1016/j.ijbiomac.2019.04.040
   Cho M, 2014, CARBOHYD POLYM, V113, P507, DOI 10.1016/j.carbpol.2014.07.055
   Chung HT, 2014, INTEGR MED RES, V3, P198, DOI 10.1016/j.imr.2014.09.005
   Cumashi A, 2007, GLYCOBIOLOGY, V17, P541, DOI 10.1093/glycob/cwm014
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Dixon P, 2003, J VEG SCI, V14, P927, DOI 10.1111/j.1654-1103.2003.tb02228.x
   El Kaoutari A, 2013, NAT REV MICROBIOL, V11, P497, DOI 10.1038/nrmicro3050
   Fraulob JC, 2010, J CLIN BIOCHEM NUTR, V46, P212, DOI 10.3164/jcbn.09-83
   Fujisaka S, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-62506-w
   Galisteo M, 2008, J NUTR BIOCHEM, V19, P71, DOI 10.1016/j.jnutbio.2007.02.009
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000111245.75752.C6
   Heal DJ, 2009, BRIT J CLIN PHARMACO, V68, P861, DOI 10.1111/j.1365-2125.2009.03549.x
   Hu SW, 2019, J FUNCT FOODS, V57, P59, DOI 10.1016/j.jff.2019.03.033
   Jeong YT, 2013, MOL PHARMACOL, V84, P147, DOI 10.1124/mol.113.085100
   Khanal RC, 2012, J MED FOOD, V15, P802, DOI 10.1089/jmf.2011.0212
   Lehrke M, 2005, CELL, V123, P993, DOI 10.1016/j.cell.2005.11.026
   Lidfeldt J, 2003, DIABETES OBES METAB, V5, P106, DOI 10.1046/j.1463-1326.2003.00250.x
   Lorincz AM, 2006, ENDOCR-RELAT CANCER, V13, P279, DOI 10.1677/erc.1.00729
   Parekh PJ, 2014, FRONT ENDOCRINOL, V5, DOI 10.3389/fendo.2014.00047
   Park MK, 2011, MAR DRUGS, V9, P1359, DOI 10.3390/md9081359
   Peng YB, 2018, J FUNCT FOODS, V51, P8, DOI 10.1016/j.jff.2018.10.013
   Saxton RA, 2017, CELL, V168, P960, DOI [10.1016/j.cell.2017.02.004, 10.1016/j.cell.2017.03.035]
   Segata N, 2011, GENOME BIOL, V12, DOI 10.1186/gb-2011-12-6-r60
   Shang QS, 2017, J FUNCT FOODS, V28, P138, DOI 10.1016/j.jff.2016.11.002
   Shang QS, 2016, FOOD FUNCT, V7, P3224, DOI [10.1039/C6FO00309E, 10.1039/c6fo00309e]
   Shin NR, 2015, TRENDS BIOTECHNOL, V33, P496, DOI 10.1016/j.tibtech.2015.06.011
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Tsai Franklin, 2009, Curr Gastroenterol Rep, V11, P307, DOI 10.1007/s11894-009-0045-z
   Wang J, 2020, INT J BIOL MACROMOL, V150, P304, DOI 10.1016/j.ijbiomac.2020.02.087
   Wang J, 2010, INT J BIOL MACROMOL, V47, P126, DOI 10.1016/j.ijbiomac.2010.05.010
   Wang LL, 2020, FOOD FUNCT, V11, P5595, DOI [10.1039/d0fo00668h, 10.1039/D0FO00668H]
   Wang X, 2018, INT J BIOL MACROMOL, V115, P861, DOI 10.1016/j.ijbiomac.2018.04.042
   Wang Y, 2015, INT J MOL MED, V35, P1067, DOI 10.3892/ijmm.2015.2095
   Xia T, 2020, FOOD FUNCT, V11, P2898, DOI [10.1039/C9FO03015H, 10.1039/c9fo03015h]
   Xiang XX, 2015, DIABETES, V64, P519, DOI 10.2337/db14-0427
   Xue ML, 2019, NUTR METAB, V16, DOI 10.1186/s12986-019-0392-1
   Yokota T, 2016, J NUTR BIOCHEM, V32, P46, DOI 10.1016/j.jnutbio.2016.01.011
   You LJ, 2020, INT J FOOD SCI TECH, V55, P1199, DOI 10.1111/ijfs.14408
   Yu ST, 2003, J BIOL CHEM, V278, P498, DOI 10.1074/jbc.M210062200
   Zhang X, 2020, LWT-FOOD SCI TECHNOL, V130, DOI 10.1016/j.lwt.2020.109635
   Zheng YY, 2018, INT J BIOL MACROMOL, V112, P929, DOI 10.1016/j.ijbiomac.2018.02.072
   Zhu LM, 2017, FEMS MICROBIOL LETT, V364, DOI 10.1093/femsle/fnx075
   Zimta AA, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20215364
NR 49
TC 8
Z9 8
U1 12
U2 54
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0141-8130
EI 1879-0003
J9 INT J BIOL MACROMOL
JI Int. J. Biol. Macromol.
PD DEC 15
PY 2021
VL 193
BP 789
EP 798
DI 10.1016/j.ijbiomac.2021.10.188
EA NOV 2021
PN A
PG 10
WC Biochemistry & Molecular Biology; Chemistry, Applied; Polymer Science
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry; Polymer Science
GA XN5PU
UT WOS:000729557700002
PM 34743939
DA 2023-06-08
ER

PT J
AU Huang, CJ
   Wu, D
   Zhang, KJ
   Khan, FA
   Pandupuspitasari, NS
   Wang, YS
   Huo, LJ
   Sun, F
AF Huang, Chunjie
   Wu, Di
   Zhang, Kejia
   Khan, Faheem Ahmed
   Pandupuspitasari, Nuruliarizki Shinta
   Wang, Yongsheng
   Huo, Lijun
   Sun, Fei
TI Perfluorooctanoic acid alters the developmental trajectory of female
   germ cells and embryos in rodents and its potential mechanism
SO ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
LA English
DT Article
DE Perfluorooctanoic acid; Reproductive health; Fetal growth retardation;
   Gut microbiota; Serine metabolism
ID GUT MICROBIOTA; FETAL-GROWTH; SERINE METABOLISM; ARCHITECTURE
AB The epidemiological studies regarding perfluorooctanoic acid (PFOA) suggests that its exposure causes reproductive health issues, the underlying mechanisms of which are still in its infancy. Here, we report that PFOA deteriorates female reproduction at multiple development stages. Oocyte meiosis and preimplantation development are severely impaired by PFOA with oxidative stress being a contributor. Supplementing with antioxidant melatonin partially rescues oocyte meiotic maturation and non-apoptotic demise. The attenuation in ovarian follicle development however can be improved by metformin but not melatonin. Importantly, metformin blunts PFOA-induced fetal growth retardation (FGR) and such protective effect could be recapitulated by transplantation of fecal material and pharmacological activation of AMPK. Mechanistically, PFOA causes gut microbiota dysbiosis, which might thereby rewire host metabolism of L-phenylalanine, histamine and L-palmitoylcarnitine that triggers hyperphenylalaninaemia, inflammation and ferroptosis to initiate FGR. Deregulated serine metabolism by the gut microbe constitutes an alternative mechanism underlying PFOA-induced FGR in that modulation of serine in dam's diet phenocopied the FGR. Our study expands the understanding of risk factors that impair human reproductive health, and proposes restoration of gut microbiota diversity and intervention of metabolism as therapeutics mitigating health risks predisposed by environmental perturbation.
C1 [Huang, Chunjie; Wu, Di; Zhang, Kejia; Sun, Fei] Nantong Univ, Sch Med, Inst Reprod Med, Nantong 226001, Peoples R China.
   [Khan, Faheem Ahmed] Univ Cent Punjab, Fac Sci & Technol, Dept Zool, Lahore 54782, Pakistan.
   [Khan, Faheem Ahmed] Chulalongkorn Univ, Fac Allied Hlth Sci, Dept Transfus Med & Clin Microbiol, Bangkok 10330, Thailand.
   [Pandupuspitasari, Nuruliarizki Shinta] Univ Diponegoro, Fac Anim & Agr Sci, Semarang 1269, Indonesia.
   [Wang, Yongsheng; Huo, Lijun] Huazhong Agr Univ, Coll Anim Sci & Technol, Wuhan 430070, Peoples R China.
C3 Nantong University; University of Central Punjab; Chulalongkorn
   University; Diponegoro University; Huazhong Agricultural University
RP Huang, CJ; Sun, F (通讯作者)，Nantong Univ, Sch Med, Inst Reprod Med, Nantong 226001, Peoples R China.; Huo, LJ (通讯作者)，Huazhong Agr Univ, Coll Anim Sci & Technol, Wuhan 430070, Peoples R China.
EM goodlife.huang@ntu.edu.cn; ljhuo@mail.hzau.edu.cn; sunfei@ntu.edu.cn
RI Huang, Chunjie/GXH-6940-2022; Huang, Chunjie/GWV-1552-2022
OI Huang, Chunjie/0000-0002-7784-6325
FU National Key Research and Development Program of China [2021YFC2700200];
   Start-up Foundation of Nantong University [135420631137, 135420631139];
   Scientific Research Funds of Nantong University Medical School
   [TDYX2020007]; Fundamental Research Funds for the Central University
   [2662020DKPY011]
FX This work was supported by the National Key Research and Development
   Program of China (No. 2021YFC2700200 to F.S), the Start-up Foundation of
   Nantong University (No. 135420631137 to C.H and No. 135420631139 to
   D.W), the Scientific Research Funds of Nantong University Medical School
   (No. TDYX2020007 to C.H) and the Fundamental Research Funds for the
   Central University (No. 2662020DKPY011 to L.H).
CR Bao XR, 2016, ELIFE, V5, DOI 10.7554/eLife.10575
   Blake BE, 2020, ENVIRON HEALTH PERSP, V128, DOI 10.1289/EHP6233
   Blau N, 2010, LANCET, V376, P1417, DOI 10.1016/S0140-6736(10)60961-0
   Cerdo T, 2018, J PHYSIOL BIOCHEM, V74, P159, DOI 10.1007/s13105-017-0577-x
   Chen X, 2020, GUT, V69, P513, DOI 10.1136/gutjnl-2019-319101
   Cybulsky AV, 2017, NAT REV NEPHROL, V13, P681, DOI 10.1038/nrneph.2017.129
   DeJong EN, 2020, CELL HOST MICROBE, V28, P180, DOI 10.1016/j.chom.2020.07.013
   Ducker GS, 2017, CELL METAB, V25, P27, DOI 10.1016/j.cmet.2016.08.009
   Fei CY, 2007, ENVIRON HEALTH PERSP, V115, P1677, DOI 10.1289/ehp.10506
   Franco ME, 2020, TOXICOLOGY, V430, DOI 10.1016/j.tox.2019.152339
   Gao X, 2018, CELL REP, V22, P3507, DOI 10.1016/j.celrep.2018.03.017
   Green ES, 2020, SEMIN IMMUNOPATHOL, V42, P413, DOI 10.1007/s00281-020-00807-y
   Henrick BM, 2021, CELL, V184, P3884, DOI 10.1016/j.cell.2021.05.030
   Hillert A, 2020, AM J HUM GENET, V107, P234, DOI 10.1016/j.ajhg.2020.06.006
   Huang CJ, 2017, BBA-MOL CELL RES, V1864, P1195, DOI 10.1016/j.bbamcr.2017.03.005
   Huang CJ, 2022, TOXICOL LETT, V358, P48, DOI 10.1016/j.toxlet.2022.01.010
   Huang CJ, 2016, MOL BIOL CELL, V27, P1776, DOI 10.1091/mbc.E16-02-0132
   Huang LH, 2021, BMC MICROBIOL, V21, DOI 10.1186/s12866-021-02327-7
   Huang SW, 2021, LIPIDS HEALTH DIS, V20, DOI 10.1186/s12944-021-01521-w
   Hwang S, 2017, CELL REP, V21, P3807, DOI 10.1016/j.celrep.2017.11.103
   Jiang XJ, 2021, NAT REV MOL CELL BIO, V22, P266, DOI 10.1038/s41580-020-00324-8
   Kaplan E, 2018, P NATL ACAD SCI USA, V115, P9628, DOI 10.1073/pnas.1722677115
   Koh A, 2020, CELL METAB, V32, P643, DOI 10.1016/j.cmet.2020.07.012
   Korpela K, 2020, CELL, V183, P324, DOI 10.1016/j.cell.2020.08.047
   Kurniawan H, 2020, CELL METAB, V31, P920, DOI 10.1016/j.cmet.2020.03.004
   Lee H, 2020, NAT CELL BIOL, V22, DOI 10.1038/s41556-020-0461-8
   Liu YX, 2020, ENVIRON INT, V144, DOI 10.1016/j.envint.2020.106012
   Locasale JW, 2013, NAT REV CANCER, V13, P572, DOI 10.1038/nrc3557
   Maisonet M, 2012, ENVIRON HEALTH PERSP, V120, P1432, DOI 10.1289/ehp.1003096
   Moholdt T, 2020, TRENDS ENDOCRIN MET, V31, P561, DOI 10.1016/j.tem.2020.03.002
   Nagaoka SI, 2012, NAT REV GENET, V13, P493, DOI 10.1038/nrg3245
   Negri E, 2017, CRIT REV TOXICOL, V47, P482, DOI 10.1080/10408444.2016.1271972
   Newman AC, 2017, TRENDS CELL BIOL, V27, P645, DOI 10.1016/j.tcb.2017.05.001
   Radford-Smith DE, 2022, P NATL ACAD SCI USA, V119, DOI 10.1073/pnas.2108581119
   Saloojee H, 2015, LANCET GLOB HEALTH, V3, pE342, DOI 10.1016/S2214-109X(15)00034-0
   Sampson TR, 2016, CELL, V167, P1469, DOI 10.1016/j.cell.2016.11.018
   Shane HL, 2020, FOOD CHEM TOXICOL, V136, DOI 10.1016/j.fct.2020.111114
   Shao Y, 2019, NATURE, V574, P117, DOI 10.1038/s41586-019-1560-1
   Shen L, 2021, CELL METAB, V33, P971, DOI 10.1016/j.cmet.2021.03.006
   Shi LC, 2020, J AGR FOOD CHEM, V68, P13916, DOI 10.1021/acs.jafc.0c05834
   Sovio U, 2020, NAT MED, V26, P348, DOI 10.1038/s41591-020-0804-9
   Tournaye H, 2017, LANCET DIABETES ENDO, V5, P544, DOI 10.1016/S2213-8587(16)30040-7
   Velmurugan G, 2020, TRENDS ENDOCRIN MET, V31, P835, DOI 10.1016/j.tem.2020.01.013
   Vuong HE, 2020, NATURE, V586, P281, DOI 10.1038/s41586-020-2745-3
   Wang T, 2016, ENVIRON SCI TECHNOL, V50, P11584, DOI 10.1021/acs.est.6b03752
   Wang X, 2020, GUT MICROBES, V12, DOI 10.1080/19490976.2020.1840765
   Yang M, 2016, NAT REV CANCER, V16, P650, DOI 10.1038/nrc.2016.81
   Zhang RX, 2021, SIGNAL TRANSDUCT TAR, V6, DOI 10.1038/s41392-021-00613-4
   Zhang YF, 2019, NAT REV ENDOCRINOL, V15, P489, DOI 10.1038/s41574-019-0226-2
NR 49
TC 2
Z9 2
U1 9
U2 22
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0147-6513
EI 1090-2414
J9 ECOTOX ENVIRON SAFE
JI Ecotox. Environ. Safe.
PD MAY 1
PY 2022
VL 236
AR 113467
DI 10.1016/j.ecoenv.2022.113467
EA APR 2022
PG 11
WC Environmental Sciences; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Toxicology
GA 2R6CC
UT WOS:000821197000003
PM 35390687
OA gold
DA 2023-06-08
ER

PT J
AU Toejing, P
   Khat-Udomkiri, N
   Intakhad, J
   Sirilun, S
   Chaiyasut, C
   Lailerd, N
AF Toejing, Parichart
   Khat-Udomkiri, Nuntawat
   Intakhad, Jannarong
   Sirilun, Sasithorn
   Chaiyasut, Chaiyavat
   Lailerd, Narissara
TI Putative Mechanisms Responsible for the Antihyperglycemic Action of
   Lactobacillus paracasei HII01 in Experimental Type 2 Diabetic Rats
SO NUTRIENTS
LA English
DT Article
DE type 2 diabetes mellitus; gut microbiota; Lactobacillus paracasei;
   antihyperglycemia
ID GUT MICROBIOTA; INSULIN-RESISTANCE; GLUT4 TRANSLOCATION; GLUCOSE-UPTAKE;
   PROBIOTICS; SENSITIVITY; OBESITY; MODEL; MICE
AB Despite the updated knowledge of the impact of gut dysbiosis on diabetes, investigations into the beneficial effects of individual bacteria are still required. This study evaluates the antihyperglycemic efficacy of Lactobacillus paracasei HII01 and its possible mechanisms in diabetic rats. Diabetic rats were assigned to receive vehicle, L. paracasei HII01 (10(8) CFU/day), metformin 30 (mg/kg) or a combination of L. paracasei HII01 and metformin. Normal rats given vehicle and L. paracasei HII01 were included. Metabolic parameters, including in vitro hemi-diaphragm glucose uptake, skeletal insulin-signaling proteins, plasma lipopolysaccharide (LPS), gut permeability, composition of gut microbiota and its metabolites, as well as short-chain fatty acids (SCFAs), were assessed after 12 weeks of experiment. The results clearly demonstrated that L. paracasei HII01 improved glycemic parameters, glucose uptake, insulin-signaling proteins including pAkt(Ser473), glucose transporter 4 (GLUT4) and phosphorylation of AMP-activated protein kinase (pAMPK(Thr172)), tumor necrosis factor (TNF-alpha) and nuclear factor-kappa B (NF-kB) in diabetic rats. Modulation of gut microbiota was found together with improvement in leaky gut, endotoxemia and SCFAs in diabetic rats administered L. paracasei HII01. In conclusion, L. paracasei HII01 alleviated hyperglycemia in diabetic rats primarily by modulating gut microbiota along with lessening leaky gut, leading to improvement in endotoxemia and inflammation-disturbed insulin signaling, which was mediated partly by PI3K/Akt signaling and AMPK activation.
C1 [Toejing, Parichart; Intakhad, Jannarong; Lailerd, Narissara] Chiang Mai Univ, Dept Physiol, Fac Med, Chiang Mai 50200, Thailand.
   [Khat-Udomkiri, Nuntawat; Sirilun, Sasithorn; Chaiyasut, Chaiyavat; Lailerd, Narissara] Chiang Mai Univ, Dept Pharmaceut Sci, Fac Pharm, Innovat Ctr Holist Hlth Nutraceut & Cosmeceut, Chiang Mai 50200, Thailand.
C3 Chiang Mai University; Chiang Mai University
RP Lailerd, N (通讯作者)，Chiang Mai Univ, Dept Physiol, Fac Med, Chiang Mai 50200, Thailand.; Lailerd, N (通讯作者)，Chiang Mai Univ, Dept Pharmaceut Sci, Fac Pharm, Innovat Ctr Holist Hlth Nutraceut & Cosmeceut, Chiang Mai 50200, Thailand.
EM lookplanoi_@hotmail.com; mysan_t_u_s@hotmail.com;
   Jannarong.7051@gmail.com; sasithorn.s@cmu.ac.th; chaiyavat@gmail.com;
   narissara.lailerd@cmu.ac.th
RI chaiyasut, chaiyavat/AAU-8085-2021
OI chaiyasut, chaiyavat/0000-0002-1633-2419; SIRILUN,
   SASITHORN/0000-0002-1508-2358; Khat-udomkiri,
   Nuntawat/0000-0003-2635-3229; Lailerd, Narissara/0000-0002-5439-5365
FU Research and Researchers for Industries (RRi) grant under the Thailand
   Science Research and Innovation (TSRI) [PHD60I0085]; National Research
   Council of Thailand (NRCT) [270390]; Chiang Mai University
FX This research was funded by the Research and Researchers for Industries
   (RRi) grant to P.T and N.L. (PHD60I0085) under the Thailand Science
   Research and Innovation (TSRI), the National Research Council of
   Thailand (NRCT) to NL (Grant No. 270390) and Chiang Mai University for
   partially support.
CR Allin KH, 2015, EUR J ENDOCRINOL, V172, pR167, DOI 10.1530/EJE-14-0874
   Amati F, 2011, DIABETES, V60, P2588, DOI 10.2337/db10-1221
   Amer Diabet Assoc, 2009, DIABETES CARE, V32, pS62, DOI [10.2337/dc11-S011, 10.2337/dc09-S062, 10.2337/dc19-S002, 10.2337/dc18-S002, 10.2337/dc12-S064]
   Ang ZW, 2018, FASEB J, V32, P289, DOI 10.1096/fj.201700252RR
   Backhed F, 2004, P NATL ACAD SCI USA, V101, P15718, DOI 10.1073/pnas.0407076101
   Bagarolli RA, 2017, J NUTR BIOCHEM, V50, P16, DOI 10.1016/j.jnutbio.2017.08.006
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Carvalho BM, 2013, MEDIAT INFLAMM, V2013, DOI 10.1155/2013/986734
   Christensen Ellen Gerd, 2014, BMC Res Notes, V7, P660, DOI 10.1186/1756-0500-7-660
   Condette CJ, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0102217
   Deshpande AD, 2008, PHYS THER, V88, P1254, DOI 10.2522/ptj.20080020
   Donato J, 2010, ARQ BRAS ENDOCRINOL, V54, P591, DOI 10.1590/S0004-27302010000700002
   FRAYN KN, 1980, J LIPID RES, V21, P139
   Gerard C, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00029
   Ghonim E.M., 2016, MENOUFIA MED J, V29, P846
   Gill SR, 2006, SCIENCE, V312, P1355, DOI 10.1126/science.1124234
   Hobbs S, 2018, PHYSIOL REP, V6, DOI 10.14814/phy2.13914
   Hsieh FC, 2013, NUTR METAB, V10, DOI 10.1186/1743-7075-10-35
   Hu GX, 2010, MED HYPOTHESES, V74, P123, DOI 10.1016/j.mehy.2009.07.022
   Jayashree B, 2014, MOL CELL BIOCHEM, V388, P203, DOI 10.1007/s11010-013-1911-4
   Khat-udomkiri N, 2020, FOOD SCI NUTR, V8, P428, DOI 10.1002/fsn3.1327
   Khorami S.A.H., 2015, ANN MED BIOMED SCI, V1, P46
   Kim JJ, 2010, GASTROENT RES PRACT, V2010, DOI 10.1155/2010/212563
   Kim KA, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0047713
   Kim SH, 2014, J APPL MICROBIOL, V117, P834, DOI 10.1111/jam.12573
   Kocsis T, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-68440-1
   Kohei K., 2010, JPN MED ASS J, V53, P41, DOI DOI 10.1016/S0140-6736(13)62154-6
   Kurth-Kraczek EJ, 1999, DIABETES, V48, P1667, DOI 10.2337/diabetes.48.8.1667
   Li X, 2017, BENEF MICROBES, V8, P421, DOI 10.3920/BM2016.0167
   Lim SM, 2016, NUTR RES, V36, P337, DOI 10.1016/j.nutres.2015.12.001
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   MATTHEWS JNS, 1990, BRIT MED J, V300, P230, DOI 10.1136/bmj.300.6719.230
   Panwar H, 2013, DIABETES-METAB RES, V29, P103, DOI 10.1002/dmrr.2376
   Petrone A, 2006, OBESITY, V14, P1498, DOI 10.1038/oby.2006.172
   Puddu Alessandra, 2014, Mediators Inflamm, V2014, P162021, DOI 10.1155/2014/162021
   Shah N., 2017, EMJ DIABETES, V5, P104, DOI [10.33590/emjdiabet/10310327, DOI 10.33590/EMJDIABET/10310327]
   Silva YP, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.00025
   Srinivasan K, 2005, PHARMACOL RES, V52, P313, DOI 10.1016/j.phrs.2005.05.004
   Stanford KI, 2014, ADV PHYSIOL EDUC, V38, P308, DOI 10.1152/advan.00080.2014
   Summers SA, 1998, MOL CELL BIOL, V18, P5457, DOI 10.1128/MCB.18.9.5457
   Thabet HS, 2008, PARASITOL RES, V103, P595, DOI 10.1007/s00436-008-1016-2
   Thiennimitr P, 2018, NUTRITION, V54, P40, DOI 10.1016/j.nut.2018.03.005
   Wanchai K, 2018, CLIN SCI, V132, P1545, DOI 10.1042/CS20180148
   Wiwanitkit V, 2011, J TRAVEL MED, V18, P70, DOI 10.1111/j.1708-8305.2010.00485_1.x
   Yamauchi T, 2002, NAT MED, V8, P1288, DOI 10.1038/nm788
   Zhang QQ, 2016, MEDICINA-LITHUANIA, V52, P28, DOI 10.1016/j.medici.2015.11.008
NR 46
TC 15
Z9 15
U1 3
U2 17
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD OCT
PY 2020
VL 12
IS 10
AR 3015
DI 10.3390/nu12103015
PG 18
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA OH8NQ
UT WOS:000582848900001
PM 33019697
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Zheng, JP
   Chen, M
   Ye, C
   Sun, XJ
   Jiang, N
   Zou, XJ
   Yang, HB
   Liu, HT
AF Zheng, Junping
   Chen, Man
   Ye, Cheng
   Sun, Xiongjie
   Jiang, Nan
   Zou, Xiaojuan
   Yang, Huabing
   Liu, Hongtao
TI BuZangTongLuo decoction improved hindlimb ischemia by activating
   angiogenesis and regulating gut microbiota in diabetic mice
SO JOURNAL OF ETHNOPHARMACOLOGY
LA English
DT Article
DE Diabetic ischemia; High fat diet; Vascular endothelial growth factor
   (VEGF); BuZangTongLuo formula (BZTLF); Gut microbiota; Angiogenesis
ID ENDOTHELIAL PROGENITOR CELLS; NITRIC-OXIDE; DEPLETION; EXTRACT; GINSENG;
   VEGF
AB Ethnopharmacological relevance: Seven traditional medicinal plants (including Astragalus membranaceus, Dioscorea hemsleyi, Salvia miltiorrhiza, Scrophularia ningpoensis, Ophiopogon japonicus, Panax ginseng and Fritillariae cirrhosae) and one insect leech (Whitmania pigra Whitman) were combined into BuZangTongLuo formula (BZTLF) under the guidance of traditional Chinese medicine. BZTLF is potentially effective against diabetic vascular complications.
   Aim of the study: Previous studies failed to clarify the molecular mechanism through which BZTLF suppressed diabetic ischemia. In this study, we aimed to explore whether BZTLF treatment could prevent the occurrence of type 2 diabetic (T2D) hindlimb ischemia in mice. Further, we investigated the regulatory effect of BZTLF on angiogenesis-related VEGF signaling pathway and gut microbiota dysfunction in diabetic ischemia mice.
   Materials and methods: C57BL/6J mice fed with high-fat diet (HFD) received STZ injection and femoral artery ligation to build T2D diabetic hindlimb ischemia model. Mice were gavaged with BZTLF (5 g [raw materials]/kg/d) or with, metformin plus atorvastatin for three weeks. Laser doppler imaging system was utilized for the visualization of blood flow. Histochemistry analysis was performed for microvascular vessel staining. Western blot was applied to detect the protein changes of signaling molecules responsible for VEGF pathway. Finally, 16S rDNA gene sequencing was conducted for analysis of gut microbiota structure.
   Results: BZTLF treatment remarkably restored blood flow and capillary density of diabetic hindlimb ischemia. And the protein changes of VEGF signaling molecules were reversed in BZTLF-treated diabetic ischemia mice, including the decreased VEGF and HIF-1 alpha, and the increased NO, eNOS and p-ERK1/2. The gut microbiota analysis suggests that BZTLF treatment increased the abundances of several beneficial bacteria (Akkermansia, Bifidobacterium and Bacteroides), while decreased the populations of some harmful bacteria(Blautia, Weissella, Escherichia Shigella and Kurthia). By using Spearman's correlation analysis, these changed gut flora were positively/negatively correlated with VEGF signaling pathway or glycometabolic parameters.
   Conclusion: BZTLF displayed beneficial effects on diabetic hindlimb ischemia by reshaping the gut microbiota structure and stunning the VEGF/HIF-1 alpha pathway.
C1 [Zheng, Junping; Chen, Man; Sun, Xiongjie; Zou, Xiaojuan; Yang, Huabing; Liu, Hongtao] Hubei Univ Chinese Med, Sch Basic Med Sci, Wuhan 430065, Hubei, Peoples R China.
   [Zheng, Junping; Liu, Hongtao] Wuchang Univ Technol, Coll Life Sci, Wuhan 430223, Hubei, Peoples R China.
   [Ye, Cheng] Wuhan Customs Technol Ctr, Wuhan 430050, Hubei, Peoples R China.
   [Jiang, Nan] Hubei Prov Hosp Tradit Chinese Med, Wuhan 430061, Hubei, Peoples R China.
C3 Hubei University of Chinese Medicine; Wuchang University of Technology
RP Yang, HB; Liu, HT (通讯作者)，Hubei Univ Chinese Med, Sch Basic Med Sci, Wuhan 430065, Hubei, Peoples R China.
EM huabingyang@hbtcm.edu.cn; hongtaoliu@hbtcm.edu.cn
RI Zheng, Johny/AAX-8898-2020
OI Zheng, Johny/0000-0002-9134-572X
FU National Natural Science Foundation of China [81873098, 81903946];
   Science and Technology Commission of Hubei Province of China
   [2018ZYYD017]; Wuhan Science and Technology Bureau of Hubei Province of
   China [2017060201010221]
FX This work is supported by National Natural Science Foundation of China
   (NO. 81873098 and NO. 81903946), Science and Technology Commission of
   Hubei Province of China (NO. 2018ZYYD017), Wuhan Science and Technology
   Bureau of Hubei Province of China (NO.2017060201010221).
CR [Anonymous], HUBEI J TCM
   Apte RS, 2019, CELL, V176, P1248, DOI 10.1016/j.cell.2019.01.021
   Benakis C, 2016, NAT MED, V22, P516, DOI 10.1038/nm.4068
   Chen JM, 2019, EUR J PHARMACOL, V856, DOI 10.1016/j.ejphar.2019.172418
   Danneskiold-Samsoe NB, 2017, MOL NUTR FOOD RES, V61, DOI 10.1002/mnfr.201600528
   Dong H, 2016, EVID-BASED COMPL ALT, V2016, DOI 10.1155/2016/7895935
   Emal D, 2017, J AM SOC NEPHROL, V28, P1450, DOI 10.1681/ASN.2016030255
   Fei YX, 2017, J ETHNOPHARMACOL, V207, P57, DOI 10.1016/j.jep.2017.06.023
   Georgescu A, 2011, WORLD J DIABETES, V2, P92, DOI 10.4239/wjd.v2.i6.92
   Ghimire K, 2017, AM J PHYSIOL-CELL PH, V312, pC254, DOI 10.1152/ajpcell.00315.2016
   Gong Amy G W, 2018, Medicines (Basel), V5, DOI 10.3390/medicines5020046
   Graham DY, 2015, GASTROENTEROLOGY, V148, P719, DOI 10.1053/j.gastro.2015.01.040
   Guo MZ, 2015, J ETHNOPHARMACOL, V162, P7, DOI 10.1016/j.jep.2014.12.029
   Hochberg I, 2001, ANN VASC SURG, V15, P388, DOI 10.1007/s100160010089
   Huang J, 2019, NAT MICROBIOL, V4, P269, DOI 10.1038/s41564-018-0300-x
   Huang PH, 2016, J VASC SURG, V64, P1112, DOI 10.1016/j.jvs.2014.11.088
   Jing LF, 2015, EXP THER MED, V9, P2141, DOI 10.3892/etm.2015.2394
   Kim JH, 2018, J GINSENG RES, V42, P264, DOI 10.1016/j.jgr.2017.10.004
   Leung KW, 2011, ANGIOGENESIS, V14, P515, DOI 10.1007/s10456-011-9235-z
   Li ZH, 2019, J MED CHEM, V62, P5725, DOI 10.1021/acs.jmedchem.8b01596
   Luo XC, 2016, INT IMMUNOPHARMACOL, V35, P22, DOI 10.1016/j.intimp.2016.03.020
   Ma X, 2013, J ETHNOPHARMACOL, V149, P720, DOI 10.1016/j.jep.2013.07.036
   Moosavian HR, 2014, AESTHET PLAST SURG, V38, P1024, DOI 10.1007/s00266-014-0399-y
   Murohara T, 1998, J CLIN INVEST, V101, P2567, DOI 10.1172/JCI1560
   Qin GJ, 2006, J EXP MED, V203, P153, DOI 10.1084/jem.20050459
   Segata N, 2011, GENOME BIOL, V12, DOI 10.1186/gb-2011-12-6-r60
   Shen J, 2013, MOL ASPECTS MED, V34, P39, DOI 10.1016/j.mam.2012.11.001
   Shin Jeong Hwan, 2007, J Infect, V54, pe149, DOI 10.1016/j.jinf.2006.09.009
   Sun J, 2016, BRAIN RES, V1642, P180, DOI 10.1016/j.brainres.2016.03.042
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Sun YF, 2018, FOOD FUNCT, V9, P3547, DOI 10.1039/c8fo00025e
   Tang WHW, 2017, CIRC RES, V120, P1183, DOI 10.1161/CIRCRESAHA.117.309715
   Wang K, 2018, NUTRIENTS, V10, DOI 10.3390/nu10060791
   Wang LN, 2015, INT J NANOMED, V10, DOI 10.2147/IJN.S89445
   Wang Y, 2014, BIOCHEM BIOPH RES CO, V455, P119, DOI 10.1016/j.bbrc.2014.10.135
   Xie WJ, 2018, CELLS-BASEL, V7, DOI 10.3390/cells7120270
   Xu J, 2017, MED RES REV, V37, P1140, DOI 10.1002/med.21431
   Yang H, 2016, INT J STRUCT STAB DY, V16, DOI 10.1142/S0219455416400058
   [杨化冰 Yang Huabing], 2015, [时珍国医国药, Lishizhen Medicine and Materia Medica Research], V26, P2577
   Yoshiya K, 2011, AM J PHYSIOL-GASTR L, V301, pG1020, DOI 10.1152/ajpgi.00239.2011
   Zhang XX, 2016, INT J BIOL MACROMOL, V82, P711, DOI 10.1016/j.ijbiomac.2015.09.051
   Zheng Y, 2018, NAT REV ENDOCRINOL, V14, P88, DOI 10.1038/nrendo.2017.151
   Zhou HJ, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-018-05812-2
NR 43
TC 21
Z9 21
U1 4
U2 70
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-8741
EI 1872-7573
J9 J ETHNOPHARMACOL
JI J. Ethnopharmacol.
PD FEB 10
PY 2020
VL 248
AR 112330
DI 10.1016/j.jep.2019.112330
PG 11
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA JW8QY
UT WOS:000503312800045
PM 31654796
DA 2023-06-08
ER

PT J
AU Diener, C
   Gibbons, SM
   Resendis-Antonio, O
AF Diener, Christian
   Gibbons, Sean M.
   Resendis-Antonio, Osbaldo
TI MICOM: Metagenome-Scale Modeling To Infer Metabolic Interactions in the
   Gut Microbiota
SO MSYSTEMS
LA English
DT Article
DE flux balance analysis; gut microbiome; metagenome; systems biology
ID HEALTH; CHALLENGES; DIVERSITY; NUTRITION; DIET
AB Compositional changes in the gut microbiota have been associated with a variety of medical conditions such as obesity, Crohn's disease, and diabetes. However, connecting microbial community composition to ecosystem function remains a challenge. Here, we introduce MICOM, a customizable metabolic model of the human gut microbiome. By using a heuristic optimization approach based on L2 regularization, we were able to obtain a unique set of realistic growth rates that corresponded well with observed replication rates. We integrated adjustable dietary and taxon abundance constraints to generate personalized metabolic models for individual metagenomic samples. We applied MICOM to a balanced cohort of metagenomes from 186 people, including a metabolically healthy population and individuals with type 1 and type 2 diabetes. Model results showed that individual bacterial genera maintained conserved niche structures across humans, while the community-level production of short-chain fatty acids (SCFAs) was heterogeneous and highly individual specific. Model output revealed complex cross-feeding interactions that would be difficult to measure in vivo. Metabolic interaction networks differed somewhat consistently between healthy and diabetic subjects. In particular, MICOM predicted reduced butyrate and propionate production in a diabetic cohort, with restoration of SCFA production profiles found in healthy subjects following metformin treatment. Overall, we found that changes in diet or taxon abundances have highly personalized effects. We believe MICOM can serve as a useful tool for generating mechanistic hypotheses for how diet and microbiome composition influence community function. All methods are implemented in an open-source Python package, which is available at https://github.com/micom-dev/micom.
   IMPORTANCE The bacterial communities that live within the human gut have been linked to health and disease. However, we are still just beginning to understand how those bacteria interact and what potential interventions to our gut microbiome can make us healthier. Here, we present a mathematical modeling framework (named MICOM) that can recapitulate the growth rates of diverse bacterial species in the gut and can simulate metabolic interactions within microbial communities. We show that MICOM can unravel the ecological rules that shape the microbial landscape in our gut and that a given dietary or probiotic intervention can have widely different effects in different people.
C1 [Diener, Christian; Resendis-Antonio, Osbaldo] Inst Nacl Med Genom INMEGEN, Mexico City, DF, Mexico.
   [Diener, Christian; Gibbons, Sean M.] Inst Syst Biol, Seattle, WA 98109 USA.
   [Gibbons, Sean M.] Univ Washington, eSci Inst, Seattle, WA 98195 USA.
   [Resendis-Antonio, Osbaldo] Univ Nacl Autonoma Mexico, Red Apoyo Invest, Coordinac Invest Cient, Human Syst Biol Lab, Mexico City, DF, Mexico.
C3 Instituto Nacional de Medicina Genomica; Institute for Systems Biology
   (ISB); University of Washington; University of Washington Seattle;
   Universidad Nacional Autonoma de Mexico
RP Resendis-Antonio, O (通讯作者)，Inst Nacl Med Genom INMEGEN, Mexico City, DF, Mexico.; Gibbons, SM (通讯作者)，Inst Syst Biol, Seattle, WA 98109 USA.; Gibbons, SM (通讯作者)，Univ Washington, eSci Inst, Seattle, WA 98195 USA.; Resendis-Antonio, O (通讯作者)，Univ Nacl Autonoma Mexico, Red Apoyo Invest, Coordinac Invest Cient, Human Syst Biol Lab, Mexico City, DF, Mexico.
EM sgibbons@isbscience.org; oresendis@inmegen.gob.mx
RI Diener, Christian/X-9574-2019; Gibbons, Sean M./ABH-2562-2020; RESENDIS,
   OSBALDO/ADE-5280-2022
OI Diener, Christian/0000-0002-7476-0868; Gibbons, Sean
   M./0000-0002-8724-7916; RESENDIS, OSBALDO/0000-0001-5220-541X
FU National Institute of Genomic Medicine (INMEGEN/Mexico); Washington
   Research Foundation Distinguished Investigator Award; Institute for
   Systems Biology
FX O.R.-A. and C.D. were supported by an internal grant from the National
   Institute of Genomic Medicine (INMEGEN/Mexico). S.M.G. and C.D. were
   supported by a Washington Research Foundation Distinguished Investigator
   Award and startup funds from the Institute for Systems Biology.
CR Arumugam M, 2011, NATURE, V473, P174, DOI 10.1038/nature09944
   Asshauer KP, 2015, BIOINFORMATICS, V31, P2882, DOI 10.1093/bioinformatics/btv287
   Babaei P, 2018, NAT BIOTECHNOL, V36, P682, DOI 10.1038/nbt.4213
   Bajaj JS, 2012, AM J PHYSIOL-GASTR L, V303, pG675, DOI 10.1152/ajpgi.00152.2012
   Bauer E, 2018, MSYSTEMS, V3, DOI 10.1128/mSystems.00209-17
   Baxter NT, 2019, MBIO, V10, DOI [10.1128/mBio.02566-18, 10.1128/mbio.02566-18]
   Brown CT, 2016, NAT BIOTECHNOL, V34, P1256, DOI 10.1038/nbt.3704
   Brown K, 2012, NUTRIENTS, V4, P1095, DOI [10.3390/nu4081095, 10.3390/nu4111552]
   Callahan BJ, 2016, NAT METHODS, V13, P581, DOI [10.1038/NMETH.3869, 10.1038/nmeth.3869]
   Chan SHJ, 2017, PLOS COMPUT BIOL, V13, DOI 10.1371/journal.pcbi.1005539
   Chen WG, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0039743
   Cho I, 2012, NAT REV GENET, V13, P260, DOI 10.1038/nrg3182
   Coyte KZ, 2015, SCIENCE, V350, P663, DOI 10.1126/science.aad2602
   Dadi TH, 2017, PEERJ, V5, DOI 10.7717/peerj.3138
   Duvallet C, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-01973-8
   Ebrahim A, 2013, BMC SYST BIOL, V7, DOI 10.1186/1752-0509-7-74
   Engl H. W., 2000, REGULARIZATION INVER
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Gibbons SM, 2017, PLOS COMPUT BIOL, V13, DOI 10.1371/journal.pcbi.1005364
   Gilbert JA, 2018, NAT MED, V24, P392, DOI 10.1038/nm.4517
   Heinken A, 2013, GUT MICROBES, V4, P28, DOI 10.4161/gmic.22370
   HEINRICH R, 1974, EUR J BIOCHEM, V42, P89, DOI 10.1111/j.1432-1033.1974.tb03318.x
   Hillmann B, 2018, MSYSTEMS, V3, DOI 10.1128/mSystems.00069-18
   HOERL AE, 1970, TECHNOMETRICS, V12, P55, DOI 10.1080/00401706.1970.10488634
   Huttenhower C, 2012, NATURE, V486, P207, DOI 10.1038/nature11234
   Johnson AJ, 2019, CELL HOST MICROBE, V25, P789, DOI 10.1016/j.chom.2019.05.005
   Kiela PR, 2016, BEST PRACT RES CL GA, V30, P145, DOI 10.1016/j.bpg.2016.02.007
   Kinross JM, 2011, GENOME MED, V3, DOI 10.1186/gm228
   Korem T, 2015, SCIENCE, V349, P1101, DOI 10.1126/science.aac4812
   Koren O, 2012, CELL, V150, P470, DOI 10.1016/j.cell.2012.07.008
   Lagier JC, 2012, FRONT CELL INFECT MI, V2, DOI 10.3389/fcimb.2012.00136
   Langille MGI, 2013, NAT BIOTECHNOL, V31, P814, DOI 10.1038/nbt.2676
   Lewis JD, 2015, CELL HOST MICROBE, V18, P489, DOI 10.1016/j.chom.2015.09.008
   Lewis NE, 2010, MOL SYST BIOL, V6, DOI 10.1038/msb.2010.47
   Livanos AE, 2016, NAT MICROBIOL, V1, DOI [10.1038/NMICROBIOL.2016.140, 10.1038/nmicrobiol.2016.140]
   Long MR, 2015, CURR OPIN BIOTECH, V34, P135, DOI 10.1016/j.copbio.2014.12.019
   Magnusdottir S, 2018, NAT BIOTECHNOL, V36, P686, DOI 10.1038/nbt.4212
   Magnusdottir S, 2017, NAT BIOTECHNOL, V35, P81, DOI 10.1038/nbt.3703
   Mahfouz A, 2015, METHODS, V73, P79, DOI 10.1016/j.ymeth.2014.10.004
   McCann KS, 2000, NATURE, V405, P228, DOI 10.1038/35012234
   Medlock GL, 2018, CELL SYST, V7, P245, DOI 10.1016/j.cels.2018.08.003
   Morgan XC, 2012, GENOME BIOL, V13, DOI 10.1186/gb-2012-13-9-r79
   Murri M, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-46
   Noronha A, 2019, NUCLEIC ACIDS RES, V47, pD614, DOI 10.1093/nar/gky992
   Orth JD, 2010, NAT BIOTECHNOL, V28, P245, DOI 10.1038/nbt.1614
   Potra FA, 2000, J COMPUT APPL MATH, V124, P281, DOI 10.1016/S0377-0427(00)00433-7
   Poyet M, 2019, NAT MED, V25, P1442, DOI 10.1038/s41591-019-0559-3
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Reese AT, 2018, NAT MICROBIOL, V3, P1441, DOI 10.1038/s41564-018-0267-7
   Resendis-Antonio O, 2007, PLOS COMPUT BIOL, V3, P1887, DOI 10.1371/journal.pcbi.0030192
   Savageau M., 2010, BIOCH SYSTEMS ANAL S
   Sender R, 2016, PLOS BIOL, V14, DOI 10.1371/journal.pbio.1002533
   Tan J, 2014, ADV IMMUNOL, V121, P91, DOI 10.1016/B978-0-12-800100-4.00003-9
   Thompson LR, 2017, NATURE, V551, P457, DOI 10.1038/nature24621
   Tremaroli V, 2012, NATURE, V489, P242, DOI 10.1038/nature11552
   Vital M, 2017, MSYSTEMS, V2, DOI 10.1128/mSystems.00130-17
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Xu ZJ, 2014, ISME J, V8, P2357, DOI 10.1038/ismej.2014.157
   Zeevi D, 2015, CELL, V163, P1079, DOI 10.1016/j.cell.2015.11.001
   Zomorrodi AR, 2012, PLOS COMPUT BIOL, V8, DOI 10.1371/journal.pcbi.1002363
NR 60
TC 67
Z9 67
U1 5
U2 32
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 2379-5077
J9 MSYSTEMS
JI mSystems
PD JAN-FEB
PY 2020
VL 5
IS 1
AR e00606-19
DI 10.1128/mSystems.00606-19
PG 17
WC Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology
GA KT2OI
UT WOS:000518855000011
PM 31964767
OA Green Published, Green Submitted, gold
DA 2023-06-08
ER

PT J
AU Huang, RX
AF Huang, Ruixue
TI Gut Microbiota: A Key Regulator in the Effects of Environmental Hazards
   on Modulates Insulin Resistance
SO FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
LA English
DT Review
DE environmental; hazards; risk; gut; microbiota; insulin
ID RADIOTHERAPY; METFORMIN; OBESITY
AB Insulin resistance is a hallmark of Alzheimer's disease (AD), type II diabetes (T2D), and Parkinson's disease (PD). Emerging evidence indicates that these disorders are typically characterized by alterations in the gut microbiota composition, diversity, and their metabolites. Currently, it is understood that environmental hazards including ionizing radiation, toxic heavy metals, pesticides, particle matter, and polycyclic aromatic hydrocarbons are capable of interacting with gut microbiota and have a non-beneficial health effect. Based on the current study, we propose the hypothesis of "gut microenvironment baseline drift ". According to this "baseline drift " theory, gut microbiota is a temporarily combined cluster of species sharing the same environmental stresses for a short period, which would change quickly under the influence of different environmental factors. This indicates that the microbial species in the gut do not have a long-term relationship; any split, division, or recombination may occur in different environments. Nonetheless, the "baseline drift " theory considers the critical role of the response of the whole gut microbiome. Undoubtedly, this hypothesis implies that the gut microbiota response is not merely a "cross junction " switch; in contrast, the human health or disease is a result of a rich palette of gut-microbiota-driven multiple-pathway responses. In summary, environmental factors, including hazardous and normal factors, are critical to the biological impact of the gut microbiota responses and the dual effect of the gut microbiota on the regulation of biological functions. Novel appreciation of the role of gut microbiota and environmental hazards in the insulin resistance would shed new light on insulin resistance and also promote the development of new research direction and new overcoming strategies for patients.
C1 [Huang, Ruixue] Cent South Univ, Xiangya Sch Publ Hlth, Dept Occupat & Environm Hlth, Changsha, Peoples R China.
C3 Central South University
RP Huang, RX (通讯作者)，Cent South Univ, Xiangya Sch Publ Hlth, Dept Occupat & Environm Hlth, Changsha, Peoples R China.
EM huangruixue@csu.edu.cn
FU National Natural Science Foundation of China [82073486, U1803124];
   Natural Science Foundation of Hunan Province [2019JJ40396]
FX Funding This study was supported by the National Natural Science
   Foundation of China (Grant Nos. 82073486 and U1803124) and the Natural
   Science Foundation of Hunan Province (Grant No. 2019JJ40396).
CR Alard J, 2016, ENVIRON MICROBIOL, V18, P1484, DOI 10.1111/1462-2920.13181
   Alderete TL, 2018, ENVIRON RES, V161, P472, DOI 10.1016/j.envres.2017.11.046
   Almeida A, 2019, NATURE, V568, P499, DOI 10.1038/s41586-019-0965-1
   Assefa S, 2020, CURR OPIN TOXICOL, V19, P21, DOI 10.1016/j.cotox.2019.09.009
   Azizova TV, 2020, INT J EPIDEMIOL, V49, P435, DOI 10.1093/ije/dyz230
   Backhed F, 2004, P NATL ACAD SCI USA, V101, P15718, DOI 10.1073/pnas.0407076101
   Bailey MJ, 2020, GUT MICROBES, V11, P1188, DOI 10.1080/19490976.2020.1749754
   Bajaj JS, 2015, SCI REP-UK, V5, DOI 10.1038/srep18559
   Bhat M, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-10471-2
   Blasco-Baque V, 2017, GUT, V66, P872, DOI 10.1136/gutjnl-2015-309897
   Bradley CA, 2017, NAT REV ENDOCRINOL, V13, P440, DOI 10.1038/nrendo.2017.72
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   Cardoso S, 2020, INT REV NEUROBIOL, V155, P37, DOI 10.1016/bs.irn.2020.02.010
   Cervantes JL, 2016, INT REV IMMUNOL, V35, P67, DOI 10.3109/08830185.2015.1027821
   Chakaroun RM, 2020, NUTRIENTS, V12, DOI 10.3390/nu12041082
   Chiu KR, 2020, TOXICOL SCI, V176, P253, DOI 10.1093/toxsci/kfaa065
   Conteh AR, 2020, TOXICOL RES-UK, V9, P569, DOI 10.1093/toxres/tfaa065
   Dabke K, 2019, J CLIN INVEST, V129, P4050, DOI 10.1172/JCI129194
   Guimaraes KSD, 2020, FOOD FUNCT, V11, P8939, DOI [10.1039/d0fo01718c, 10.1039/D0FO01718C]
   Dedrick S, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.00078
   DeLeo PC, 2020, ECOTOX ENVIRON SAFE, V206, DOI 10.1016/j.ecoenv.2020.111116
   Ding QZ, 2019, BIOMED PHARMACOTHER, V118, DOI 10.1016/j.biopha.2019.109262
   Dosoky NS, 2020, APPL MICROBIOL BIOT, V104, P7657, DOI 10.1007/s00253-020-10771-0
   Dubois NE, 2021, BIOL RES NURS, V23, P21, DOI 10.1177/1099800420941185
   Fadda HM, 2020, AAPS PHARMSCITECH, V21, DOI 10.1208/s12249-020-1637-z
   Genders AJ, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21186948
   Gershon MD, 2013, CURR OPIN ENDOCRINOL, V20, P14, DOI 10.1097/MED.0b013e32835bc703
   Gevers D, 2012, PLOS BIOL, V10, DOI 10.1371/journal.pbio.1001377
   Goudarzi M, 2016, RADIAT RES, V186, P219, DOI 10.1667/RR14306.1
   He FF, 2020, J OVARIAN RES, V13, DOI 10.1186/s13048-020-00670-3
   He YX, 2020, J CLIN MED, V9, DOI 10.3390/jcm9072042
   Huang RX, 2020, SCI TOTAL ENVIRON, V745, DOI 10.1016/j.scitotenv.2020.141030
   Huang RX, 2020, DOSE-RESPONSE, V18, DOI 10.1177/1559325820923828
   Huang RX, 2019, J EXP CLIN CANC RES, V38, DOI 10.1186/s13046-019-1499-y
   Jones GR, 2021, DIGEST DIS SCI, V66, P1409, DOI 10.1007/s10620-020-06390-4
   Kampmann U, 2019, J DIABETES RES, V2019, DOI 10.1155/2019/5320156
   Kaur G, 2021, CURR NEUROPHARMACOL, V19, P233, DOI 10.2174/1570159X18666200606233050
   Kesika P, 2019, BIOMED RES INT, V2019, DOI 10.1155/2019/1531567
   Kim M, 2016, CELL HOST MICROBE, V20, P202, DOI 10.1016/j.chom.2016.07.001
   Kong M, 2019, CANCER MANAG RES, V11, P7103, DOI 10.2147/CMAR.S210095
   Kosinska Irena, 2020, Pol Merkur Lekarski, V49, P282
   Lanis JM, 2017, J MOL MED, V95, P905, DOI 10.1007/s00109-017-1544-2
   Lee KJ, 2010, NEUROGASTROENT MOTIL, V22, P493, DOI 10.1111/j.1365-2982.2010.01482.x
   Lee S, 2019, NUTRIENTS, V11, DOI 10.3390/nu11091975
   Li WZ, 2020, WORLD J DIABETES, V11, P293, DOI 10.4239/wjd.v11.i7.293
   Li XJ, 2019, ENVIRON INT, V126, P454, DOI 10.1016/j.envint.2019.02.048
   Leachi HFL, 2020, REV BRAS ENFERM, V73, DOI 10.1590/0034-7167-2018-0965
   Liu HW, 2019, TRENDS ECOL EVOL, V34, P1118, DOI 10.1016/j.tree.2019.07.011
   Liu T, 2019, ENVIRON INT, V130, DOI 10.1016/j.envint.2019.05.076
   Liu W, 2020, CHEMOSPHERE, V247, DOI 10.1016/j.chemosphere.2020.125879
   Luc M, 2021, PROG NEURO-PSYCHOPH, V104, DOI 10.1016/j.pnpbp.2020.110039
   Manousi N, 2020, MOLECULES, V25, DOI 10.3390/molecules25092182
   Meng ZY, 2020, J AGR FOOD CHEM, V68, P10517, DOI 10.1021/acs.jafc.0c04678
   Morel S, 2021, ANTIOXID REDOX SIGN, V34, P223, DOI 10.1089/ars.2020.8102
   Mulak A, 2015, WORLD J GASTROENTERO, V21, P10609, DOI 10.3748/wjg.v21.i37.10609
   Najjar RS, 2019, NUTRIENTS, V11, DOI 10.3390/nu11112712
   Nakov R, 2020, CURR DRUG METAB, V21, P260, DOI 10.2174/1389200221666200303113830
   Pardo M, 2020, CHEM RES TOXICOL, V33, P1110, DOI 10.1021/acs.chemrestox.0c00007
   Powell N, 2017, NAT REV GASTRO HEPAT, V14, P143, DOI 10.1038/nrgastro.2016.191
   Roslund MI, 2019, ENVIRON INT, V130, DOI 10.1016/j.envint.2019.06.004
   Ryu JY, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21186887
   Salonen A, 2010, MICROBIOL-SGM, V156, P3205, DOI 10.1099/mic.0.043257-0
   Sharma N, 2020, J NUTR BIOCHEM, V84, DOI 10.1016/j.jnutbio.2020.108442
   Sharma R, 2020, MOL CELL ENDOCRINOL, V518, DOI 10.1016/j.mce.2020.111038
   Szydlowska Iwona, 2020, Pol Merkur Lekarski, V49, P279
   Vetrani C, 2020, ACTA DIABETOL, V57, P853, DOI 10.1007/s00592-020-01494-9
   Wang GH, 2020, CELL HOST MICROBE, V27, P213, DOI 10.1016/j.chom.2020.01.009
   Xi Y, 2021, WORLD J DIABETES, V12, P1693, DOI 10.4239/wjd.v12.i10.1693
   Yang GL, 2020, ENVIRON POLLUT, V266, DOI 10.1016/j.envpol.2020.115290
   Zhang S, 2019, CHINESE J CANCER RES, V31, P212, DOI 10.21147/j.issn.1000-9604.2019.01.16
   Zhang YJ, 2020, J HAZARD MATER, V398, DOI 10.1016/j.jhazmat.2020.122748
   Zhang ZX, 2019, NUTRIENTS, V11, DOI 10.3390/nu11102291
   Zhao YL, 2021, BIOL TRACE ELEM RES, V199, P1900, DOI 10.1007/s12011-020-02300-x
   Zwierello W, 2020, CHEMOSPHERE, V240, DOI 10.1016/j.chemosphere.2019.124901
NR 74
TC 3
Z9 3
U1 5
U2 15
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2235-2988
J9 FRONT CELL INFECT MI
JI Front. Cell. Infect. Microbiol.
PD JAN 17
PY 2022
VL 11
AR 800432
DI 10.3389/fcimb.2021.800432
PG 10
WC Immunology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Microbiology
GA YV8ME
UT WOS:000752977900001
PM 35111696
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Ojo, O
   Wang, XH
   Ojo, OO
   Brooke, J
   Jiang, YQ
   Dong, QQ
   Thompson, T
AF Ojo, Omorogieva
   Wang, Xiaohua
   Ojo, Osarhumwese Osaretin
   Brooke, Joanne
   Jiang, Yiqing
   Dong, Qingqing
   Thompson, Trevor
TI The Effect of Prebiotics and Oral Anti-Diabetic Agents on Gut Microbiome
   in Patients with Type 2 Diabetes: A Systematic Review and Network
   Meta-Analysis of Randomised Controlled Trials
SO NUTRIENTS
LA English
DT Review
DE prebiotics; oral anti-diabetic agents; gut microbiome; glycated
   haemoglobin; type 2 diabetes; Network meta-analysis; meta-analysis
ID DIETARY FIBER; METFORMIN; SUPPLEMENTATION; STATEMENT; GLUCOSE; HEALTH
AB Background: Nutritional interventions such as the use of prebiotics can promote eubiosis of gut microbiome and maintain glucose homeostasis in patients with type 2 diabetes (T2D). However, it would appear that results of the effects of prebiotics on the community of microbes in the gut are not consistent. Aim: To examine the effect of prebiotics and oral antidiabetic agents on gut microbiome in patients with T2D. Methods: The PRISMA Extension Statement for Systematic Reviews and Network Meta-analyses was used to conduct this review. Searches were carried out in EMBASE, EBSCO-host databases, Google Scholar and the reference lists of articles for studies that are relevant to the research question, from database inception to 15 August 2022. The search strategy was based on PICOS framework. Network Meta-analysis which allows the estimation of relative treatment effects by combing both direct trial evidence (e.g., treatment A vs. treatment B) and indirect evidence was conducted. Furthermore, pairwise meta-analysis was also carried out to estimate effect sizes based on head-to-head comparisons of treatments and/or control conditions. Results: Findings of the Network meta-analysis revealed that prebiotics significantly reduced HbA1c compared with control and the SMD was -0.43 [95% CI, -0.77, -0.08; p = 0.02], whereas there was no significant difference (p > 0.05) between the other treatments and control. In addition, anti-diabetic agents including glipizide and metformin also reduced HbA1C, although these were not significantly different (p > 0.05) from control. While prebiotics promoted Bifidobacterium and Akkermansia, the improvements were not significantly different (p > 0.05) from control. On the other hand, metformin decreased the relative abundance of Bifidobacterium, but increased Lactobacillus and Akkermansia, although the differences were not significant (p > 0.05) compared with control. With respect to fasting blood glucose and BMI, the effects of prebiotics and oral antidiabetic agents did not differ significantly (p > 0.05) from controls. Conclusions: The findings of the systematic review and Network meta-analysis demonstrated prebiotics were significantly (p < 0.05) more effective in reducing HbA1c than control in patients with T2D. However, the effects of prebiotics and oral antidiabetic agents did not differ significantly (p > 0.05) from the controls in relation to fasting blood glucose, post-prandial blood glucose, body mass index and the genera of gut bacteria examined. More studies are required to fully investigate the effects of prebiotics and oral antidiabetic agents in patients with T2D
C1 [Ojo, Omorogieva] Univ Greenwich, Sch Hlth Sci, Avery Hill Campus, London SE9 2UG, England.
   [Wang, Xiaohua; Jiang, Yiqing; Dong, Qingqing] Soochow Univ, Sch Nursing, Suzhou 215006, Peoples R China.
   [Ojo, Osarhumwese Osaretin] Univ Hosp, Smoking Cessat Dept, London SE13 6LH, England.
   [Brooke, Joanne] Birmingham City Univ, Fac Hlth Educ & Life Sci, Birmingham B15 3TN, England.
   [Thompson, Trevor] Univ Greenwich, Sch Human Sci, Avery Hill Campus, London SE9 2UG, England.
C3 University of Greenwich; Soochow University - China; Birmingham City
   University; University of Greenwich
RP Ojo, O (通讯作者)，Univ Greenwich, Sch Hlth Sci, Avery Hill Campus, London SE9 2UG, England.
EM o.ojo@greenwich.ac.uk
OI Brooke, Joanne/0000-0003-0325-2142; Ojo, Omorogieva/0000-0003-0071-3652;
   Thompson, Trevor/0000-0001-9880-782X; Wang, Xiaohua/0000-0003-3328-8496
CR Akbari V, 2016, NUTR REV, V74, P774, DOI 10.1093/nutrit/nuw039
   Aliloo A, 2018, WORLD FAM MED, V16, P102, DOI 10.5742/MEWFM.2018.93316
   Almugadam BS, 2020, J DIABETES RES, V2020, DOI 10.1155/2020/7253978
   Arias-Cordova Y, 2021, NUTRIENTS, V13, DOI 10.3390/nu13114052
   Birkeland E, 2020, EUR J NUTR, V59, P3325, DOI 10.1007/s00394-020-02282-5
   Bock PM, 2021, DIABETOLOGIA, V64, P26, DOI 10.1007/s00125-020-05295-1
   Candela M, 2016, BRIT J NUTR, V116, P80, DOI 10.1017/S0007114516001045
   Elbere I, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0204317
   Fallucca F, 2015, WORLD J DIABETES, V6, P403, DOI 10.4239/wjd.v6.i3.403
   Fallucca F, 2014, DIABETES-METAB RES, V30, P48, DOI 10.1002/dmrr.2518
   Fu JX, 2022, NUTRIENTS, V14, DOI 10.3390/nu14051003
   Ghorbani Y, 2021, EUR J NUTR, V60, P2361, DOI 10.1007/s00394-021-02520-4
   Gibson GR, 2017, NAT REV GASTRO HEPAT, V14, P491, DOI 10.1038/nrgastro.2017.75
   Gonai M, 2017, BENEF MICROBES, V8, P705, DOI 10.3920/BM2016.0230
   Gu YY, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-01682-2
   He DQ, 2022, CAN J DIABETES, V46, P150, DOI 10.1016/j.jcjd.2021.08.001
   Higgins Julian P T, 2011, BMJ, V343, pd5928, DOI [10.1002/14651858.CD001930.pub3, 10.1136/bmj.d5928]
   Holscher HD, 2017, GUT MICROBES, V8, P172, DOI 10.1080/19490976.2017.1290756
   Hutton B, 2015, ANN INTERN MED, V162, P777, DOI 10.7326/M14-2385
   Le KA, 2013, FRONT PHYSIOL, V3, DOI 10.3389/fphys.2012.00496
   Lee SE, 2019, DIABETES METAB J, V43, P422, DOI 10.4093/dmj.2018.0090
   Liu WH, 2022, FRONT CELL INFECT MI, V12, DOI 10.3389/fcimb.2022.853771
   Lordan C, 2020, GUT MICROBES, V11, P1, DOI 10.1080/19490976.2019.1613124
   Lv Y, 2018, J DIABETES RES, V2018, DOI 10.1155/2018/1890978
   Mahboobi S, 2018, ADV PHARM BULL, V8, P565, DOI 10.15171/apb.2018.065
   Makki K, 2018, CELL HOST MICROBE, V23, P705, DOI 10.1016/j.chom.2018.05.012
   Medina-Vera I, 2019, DIABETES METAB, V45, P122, DOI 10.1016/j.diabet.2018.09.004
   Merkevicius K, 2021, MEDICINA-LITHUANIA, V57, DOI 10.3390/medicina57101084
   Methley AM, 2014, BMC HEALTH SERV RES, V14, DOI 10.1186/s12913-014-0579-0
   Mitchell M, 2020, MARKUMMITCHELL ENGAU, DOI DOI 10.5281/ZENODO.3941227
   Ojo O, 2021, NUTRIENTS, V13, DOI 10.3390/nu13061805
   Ojo O, 2020, NUTRIENTS, V12, DOI 10.3390/nu12113239
   Page Matthew J, 2021, J Clin Epidemiol, V134, P103, DOI 10.1016/j.jclinepi.2021.02.003
   Pedersen C, 2016, BRIT J NUTR, V116, P1869, DOI 10.1017/S0007114516004086
   Prattichizzo F, 2018, AGEING RES REV, V48, P87, DOI 10.1016/j.arr.2018.10.003
   Reimer RA, 2021, EUR J NUTR, V60, P1237, DOI 10.1007/s00394-020-02328-8
   Robertson MD, 2020, PRACT DIABETES, V37, P133, DOI 10.1002/pdi.2285
   Roshanravan N, 2020, CYTOKINE, V131, DOI 10.1016/j.cyto.2020.155101
   Rucker G., 2022, NETMETA NETWORK META
   Sharma BR, 2022, BIOMED PHARMACOTHER, V152, DOI 10.1016/j.biopha.2022.113148
   Shin NR, 2020, AM J PHYSIOL-ENDOC M, V318, pE52, DOI 10.1152/ajpendo.00221.2019
   Soare A, 2016, NUTR DIABETES, V6, DOI 10.1038/nutd.2016.29
   Soare A, 2014, NUTR METAB, V11, DOI 10.1186/1743-7075-11-39
   Su BL, 2015, J DIABETES, V7, P729, DOI 10.1111/1753-0407.12232
   The Nordic Cochrane Centre, 2014, REV MAN REVMAN COMP
   Tong XL, 2018, MBIO, V9, DOI 10.1128/mBio.02392-17
   van Bommel EJM, 2020, DIABETES METAB, V46, P164, DOI 10.1016/j.diabet.2019.11.005
   Rezende ESV, 2021, NUTRITION, V89, DOI 10.1016/j.nut.2021.111217
   Wang L, 2019, J TRANSL MED, V17, DOI 10.1186/s12967-019-02159-0
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Zhang WY, 2020, J CLIN BIOCHEM NUTR, V66, P176, DOI 10.3164/jcbn.19-103
   Zhao LP, 2018, SCIENCE, V359, P1151, DOI 10.1126/science.aao5774
NR 52
TC 2
Z9 2
U1 2
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD DEC
PY 2022
VL 14
IS 23
AR 5139
DI 10.3390/nu14235139
PG 24
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 6X4IA
UT WOS:000896377400001
PM 36501168
OA Green Accepted, gold, Green Published
DA 2023-06-08
ER

PT J
AU Hou, KJ
   Zhang, S
   Wu, ZZ
   Zhu, D
   Chen, FW
   Lei, ZN
   Liu, WT
   Xiao, CX
   Chen, ZS
AF Hou, Kaijian
   Zhang, Shuo
   Wu, Zezhen
   Zhu, Dan
   Chen, Fengwu
   Lei, Zi-Ning
   Liu, Weiting
   Xiao, Chuanxing
   Chen, Zhe-Sheng
TI Reconstruction of intestinal microecology of type 2 diabetes by fecal
   microbiota transplantation: Why and how
SO BOSNIAN JOURNAL OF BASIC MEDICAL SCIENCES
LA English
DT Review
DE Fecal transplant; intestinal microecology; type 2 diabetes; stjohns; edu
ID CHAIN FATTY-ACIDS; GUT MICROBIOTA; BILE-ACIDS; INSULIN SENSITIVITY;
   METABOLIC SYNDROME; OBESITY; GLUCOSE; DIET; METFORMIN; INCREASES
AB Type 2 diabetes (T2D) is a chronic metabolic disease characterized by hyperglycemia due to insulin resistance. Mounting evidence has correlated T2D to alterations in the composition of gut microbiota. Accordingly, targeting the gut microbiota has become an emerging strategy for T2D management. The aim of this article is to get a better insight into the rationale for targeting gut microbiota in T2D treatment. Thus, we herein reviewed the change of gut microbiota composition in T2D, factors shaping gut microbiota, and potential mechanisms behind the contribution of gut microbiota to T2D pathogenesis. At present, it has become possible to use intestinal microorganism capsules, bacteria liquid, and other preparations to carry out fecal microbiota transplantation for the treatment and intervention of T2D with insulin resistance and immune-mediated type 1 diabetes.
C1 [Hou, Kaijian; Zhang, Shuo; Wu, Zezhen; Zhu, Dan; Chen, Fengwu] Shantou Univ, Longhu Hosp, Dept Endocrine & Metab Dis, Affiliated Hosp 1,Med Coll, Shantou, Guangdong, Peoples R China.
   [Hou, Kaijian; Zhang, Shuo; Wu, Zezhen] Shantou Univ, Dept Endocrine & Metab Dis, Med Coll, Shantou, Guangdong, Peoples R China.
   [Lei, Zi-Ning; Chen, Zhe-Sheng] St Johns Univ, Dept Pharmaceut Sci, Coll Pharm & Hlth Sci, Queens, NY USA.
   [Liu, Weiting] Anhui Univ Chinese Med, Coll Nursing, Dept Teaching, Hefei, Anhui, Peoples R China.
   [Liu, Weiting] Anhui Univ Chinese Med, Coll Nursing, Res Sect, Hefei, Anhui, Peoples R China.
   [Xiao, Chuanxing] Fujian Univ Tradit Chinese Med, Dept Pharm, Coll Tradit Chinese Med, Fuzhou, Fujian, Peoples R China.
C3 Shantou University; Shantou University; Saint John's University; Anhui
   University of Chinese Medicine; Anhui University of Chinese Medicine;
   Fujian University of Traditional Chinese Medicine
RP Xiao, CX (通讯作者)，Fujian Univ Tradit Chinese Med, Coll Tradit Chinese Med, 1 Huatuo Rd, Fuzhou, Peoples R China.; Liu, WT (通讯作者)，Anhui Univ Chinese Med, Coll Nursing, 350 Longzihu Rd, Hefei, Anhui, Peoples R China.; Chen, ZS (通讯作者)，St Johns Univ, Inst Biotechnol, 8000 Utopia Pkwy, New York, NY 11439 USA.
EM liuweit-ing1213@126.com; xiaoxxl@163.com; chenz@stjohns.edu
RI 刘, 维婷/HCI-8926-2022; Chen, Zhe-Sheng/AAI-7465-2020; Hou,
   Kaijian/GVU-1115-2022
OI 刘, 维婷/0000-0002-4234-9783; Chen, Zhe-Sheng/0000-0002-8289-097X; Hou,
   Kaijian/0000-0003-1733-0068
FU National Health and Health Commission of the People's Republic of
   China-NHC Key Laboratory of Health Economics and Policy Research
   [NHC-HEPR2019003]; Shantou Science and Technology Plan medical and
   health category project [190923115260372]; Research support project of
   Longhu People's Hospital [LHLL2019001]; 2020 Domestic Visiting Study and
   Training Project for Outstanding Young Backbone Talents in Colleges and
   Universities [gxgnfx202005]
FX This work was supported by grants from National Health and Health
   Commission of the People's Republic of China-NHC Key Laboratory of
   Health Economics and Policy Research (No.NHC-HEPR2019003), Shantou
   Science and Technology Plan medical and health category project
   (190923115260372) and Research support project of Longhu People's
   Hospital (LHLL2019001), and the fund of 2020 Domestic Visiting Study and
   Training Project for Outstanding Young Backbone Talents in Colleges and
   Universities, No: gxgnfx202005.
CR Agus A, 2021, GUT, V70, P1174, DOI 10.1136/gutjnl-2020-323071
   Al Assal K, 2020, NUTRIENTS, V12, DOI 10.3390/nu12020278
   Alam U, 2020, DIABETES THER, V11, P755, DOI 10.1007/s13300-020-00773-6
   Gonzalez-Regueiro JA, 2017, ANN HEPATOL, V16, pS15, DOI [10.5604/01.3001.0010.5672, 10.5604/01.3001.0010.5494]
   Almeida A, 2019, NATURE, V568, P499, DOI 10.1038/s41586-019-0965-1
   Amar J, 2011, EMBO MOL MED, V3, P559, DOI 10.1002/emmm.201100159
   [Anonymous], 2014, DIABETES CARE, V37, pS81, DOI [DOI 10.2337/dc14-S081, 10.2337/dc14-S081]
   Aoki R, 2017, SCI REP-UK, V7, DOI 10.1038/srep43522
   Arumugam M, 2011, NATURE, V473, P174, DOI 10.1038/nature09944
   Azad MB, 2013, CAN MED ASSOC J, V185, P385, DOI 10.1503/cmaj.121189
   Bai J, 2019, PEDIATR OBES, V14, DOI 10.1111/ijpo.12480
   Becattini S, 2016, TRENDS MOL MED, V22, P458, DOI 10.1016/j.molmed.2016.04.003
   Belenguer A, 2006, APPL ENVIRON MICROB, V72, P3593, DOI 10.1128/AEM.72.5.3593-3599.2006
   Belkaid Y, 2017, IMMUNITY, V46, P562, DOI 10.1016/j.immuni.2017.04.008
   Bloomgarden Z, 2018, J DIABETES, V10, P350, DOI 10.1111/1753-0407.12645
   Bolte LA, 2021, GUT, V70, P1287, DOI 10.1136/gutjnl-2020-322670
   Camilleri M, 2019, GUT, V68, P1516, DOI 10.1136/gutjnl-2019-318427
   Cani PD, 2007, DIABETOLOGIA, V50, P2374, DOI 10.1007/s00125-007-0791-0
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   Cani PD, 2018, GUT, V67, P1716, DOI 10.1136/gutjnl-2018-316723
   Caramori LM, 2003, CURR OPIN INT MED, V2, P294, DOI [10.1097/00132980-200302030-00011, DOI 10.1097/00132980-200302030-00011]
   Carding Simon, 2015, Microbial Ecology in Health and Disease, V26, P26191, DOI 10.3402/mehd.v26.26191
   Carlson JL, 2018, CURR DEV NUTR, V2, DOI 10.1093/cdn/nzy005
   Carmody RN, 2015, CELL HOST MICROBE, V17, P72, DOI 10.1016/j.chom.2014.11.010
   Carvalho BM, 2012, DIABETOLOGIA, V55, P2823, DOI 10.1007/s00125-012-2648-4
   Chavez-Carbajal A, 2020, MICROORGANISMS, V8, DOI 10.3390/microorganisms8010094
   Chen TL, 2016, SCI REP-UK, V6, DOI 10.1038/srep20594
   Chiang JYL, 2013, COMPR PHYSIOL, V3, P1191, DOI 10.1002/cphy.c120023
   Clarke SF, 2014, GUT, V63, P1913, DOI 10.1136/gutjnl-2013-306541
   Colantonio AG, 2020, J ACAD NUTR DIET, V120, P587, DOI 10.1016/j.jand.2018.12.013
   Daniel H, 2014, ISME J, V8, P295, DOI 10.1038/ismej.2013.155
   Davani-Davari D, 2019, FOODS, V8, DOI 10.3390/foods8030092
   David LA, 2014, NATURE, V505, P559, DOI 10.1038/nature12820
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   DeFronzo RA, 2015, NAT REV DIS PRIMERS, V1, DOI 10.1038/nrdp.2015.19
   den Besten G, 2013, J LIPID RES, V54, P2325, DOI 10.1194/jlr.R036012
   Derrien M, 2019, TRENDS MICROBIOL, V27, P997, DOI 10.1016/j.tim.2019.08.001
   Desai MS, 2016, CELL, V167, P1339, DOI 10.1016/j.cell.2016.10.043
   Desouza CV, 2010, DIABETES CARE, V33, P1389, DOI 10.2337/dc09-2082
   Dobbler P, 2019, WORLD J MICROB BIOT, V35, DOI 10.1007/s11274-019-2737-3
   Dominguez-Bello MG, 2016, NAT MED, V22, P250, DOI 10.1038/nm.4039
   Elvers KT, 2020, BMJ OPEN, V10, DOI 10.1136/bmjopen-2019-035677
   Estaki M, 2016, MICROBIOME, V4, DOI 10.1186/s40168-016-0189-7
   Evans CC, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0092193
   Falony G, 2016, SCIENCE, V352, P560, DOI 10.1126/science.aad3503
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Fujisaka S, 2016, J CLIN INVEST, V126, P4430, DOI 10.1172/JCI86674
   Fuke N, 2019, NUTRIENTS, V11, DOI 10.3390/nu11102277
   Cano PG, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0041079
   Greer RL, 2016, NAT COMMUN, V7, DOI 10.1038/ncomms13329
   Gribble FM, 2021, NAT METAB, V3, P142, DOI 10.1038/s42255-020-00327-x
   Gurung M, 2020, EBIOMEDICINE, V51, DOI 10.1016/j.ebiom.2019.11.051
   Harsch IA, 2019, CASE REP GASTROINTES, V2019, DOI 10.1155/2019/2543808
   He FF, 2020, J OVARIAN RES, V13, DOI 10.1186/s13048-020-00670-3
   Healey GR, 2017, NUTR REV, V75, P1059, DOI 10.1093/nutrit/nux062
   Hofmann AF, 2006, P NATL ACAD SCI USA, V103, P4333, DOI 10.1073/pnas.0600780103
   Hofmann AF, 1999, ARCH INTERN MED, V159, P2647, DOI 10.1001/archinte.159.22.2647
   Holecek M, 2018, NUTR METAB, V15, DOI 10.1186/s12986-018-0271-1
   Imhann F, 2016, GUT, V65, P740, DOI 10.1136/gutjnl-2015-310376
   Inzucchi SE, 2012, NEW ENGL J MED, V367, P542, DOI [10.1056/NEJMc1212738, 10.1056/NEJMcp1103643]
   Jakobsson HE, 2015, EMBO REP, V16, P164, DOI 10.15252/embr.201439263
   Johansson MEV, 2013, NAT REV GASTRO HEPAT, V10, P352, DOI 10.1038/nrgastro.2013.35
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kocsis T, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-68440-1
   Koh A, 2018, CELL, V175, P947, DOI 10.1016/j.cell.2018.09.055
   Konturek PC, 2011, J PHYSIOL PHARMACOL, V62, P591
   Kootte RS, 2017, CELL METAB, V26, P611, DOI 10.1016/j.cmet.2017.09.008
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Leeming ER, 2019, NUTRIENTS, V11, DOI 10.3390/nu11122862
   Li KK, 2017, J FUNCT FOODS, V38, P561, DOI 10.1016/j.jff.2017.09.049
   Lozupone CA, 2012, NATURE, V489, P220, DOI 10.1038/nature11550
   Lund ML, 2020, DIABETES, V69, P614, DOI 10.2337/db19-0764
   Ma QQ, 2019, J NEUROINFLAMM, V16, DOI 10.1186/s12974-019-1434-3
   Magne F, 2017, FRONT PEDIATR, V5, DOI 10.3389/fped.2017.00192
   MASUDA N, 1981, MICROBIOL IMMUNOL, V25, P1
   Matsumoto M, 2008, BIOSCI BIOTECH BIOCH, V72, P572, DOI 10.1271/bbb.70474
   Mocanu V, 2021, NAT MED, V27, P1272, DOI 10.1038/s41591-021-01399-2
   Morrison DJ, 2016, GUT MICROBES, V7, P189, DOI 10.1080/19490976.2015.1134082
   Neuman H, 2015, FEMS MICROBIOL REV, V39, P509, DOI 10.1093/femsre/fuu010
   Ng SC, 2022, GUT, V71, P716, DOI 10.1136/gutjnl-2020-323617
   Nguyen TT, 2008, DIABETES CARE, V31, P544, DOI 10.2337/dc07-1528
   Nishitani S, 2002, BIOCHEM BIOPH RES CO, V299, P693, DOI 10.1016/S0006-291X(02)02717-1
   O'Hara AM, 2006, EMBO REP, V7, P688, DOI 10.1038/sj.embor.7400731
   Odamaki T, 2016, BMC MICROBIOL, V16, DOI 10.1186/s12866-016-0708-5
   Palsson-McDermott EM, 2004, IMMUNOLOGY, V113, P153, DOI 10.1111/j.1365-2567.2004.01976.x
   Pham TAN, 2014, CURR OPIN MICROBIOL, V17, P67, DOI 10.1016/j.mib.2013.12.002
   Prawitt J, 2011, CURR DIABETES REP, V11, P160, DOI 10.1007/s11892-011-0187-x
   Puddu A, 2014, MEDIAT INFLAMM, V2014, DOI 10.1155/2014/162021
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Remely M, 2015, WIEN KLIN WOCHENSCHR, V127, P394, DOI 10.1007/s00508-015-0755-1
   Reyman M, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-13014-7
   Ridaura VK, 2013, SCIENCE, V341, P1079, DOI 10.1126/science.1241214
   Ridlon JM, 2014, CURR OPIN GASTROEN, V30, P332, DOI 10.1097/MOG.0000000000000057
   Saltiel AR, 2001, NATURE, V414, P799, DOI 10.1038/414799a
   Sekirov I, 2010, PHYSIOL REV, V90, P859, DOI 10.1152/physrev.00045.2009
   Shao Y, 2019, NATURE, V574, P117, DOI 10.1038/s41586-019-1560-1
   Shaterian N, 2021, OPEN MED-WARSAW, V16, P624, DOI 10.1515/med-2021-0270
   Singh RK, 2017, J TRANSL MED, V15, DOI 10.1186/s12967-017-1175-y
   Smits LP, 2013, GASTROENTEROLOGY, V145, P946, DOI 10.1053/j.gastro.2013.08.058
   Thomas C, 2009, CELL METAB, V10, P167, DOI 10.1016/j.cmet.2009.08.001
   Thursby E, 2017, BIOCHEM J, V474, P1823, DOI 10.1042/BCJ20160510
   Tiderencel KA, 2020, DIABETES-METAB RES, V36, DOI 10.1002/dmrr.3213
   Tsalamandris S, 2019, EUR CARDIOL REV, V14, P50, DOI 10.15420/ecr.2018.33.1
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Vrieze A, 2014, J HEPATOL, V60, P824, DOI 10.1016/j.jhep.2013.11.034
   Vrieze A, 2012, GASTROENTEROLOGY, V143, P913, DOI 10.1053/j.gastro.2012.06.031
   Wang H, 2020, FRONT CELL INFECT MI, V9, DOI 10.3389/fcimb.2019.00455
   Wen L, 2017, NAT IMMUNOL, V18, P484, DOI 10.1038/ni.3730
   Willing BP, 2011, NAT REV MICROBIOL, V9, P233, DOI 10.1038/nrmicro2536
   Wu HJ, 2012, GUT MICROBES, V3, P4, DOI 10.4161/gmic.19320
   Wu XK, 2010, CURR MICROBIOL, V61, P69, DOI 10.1007/s00284-010-9582-9
   Yang JY, 2017, MUCOSAL IMMUNOL, V10, P104, DOI 10.1038/mi.2016.42
   Zhang Q, 2020, DIABET METAB SYND OB, V13, P5003, DOI 10.2147/DMSO.S286430
NR 113
TC 10
Z9 10
U1 14
U2 41
PU ASSOC BASIC MEDICAL SCI FEDERATION BOSNIA & HERZEGOVINA SARAJEVO
PI CEKALUSA
PA UNIV SARAJEVO, MEDICAL FAC, CEKALUSA, SARAJEVO 90, BOSNIA & HERCEG
SN 1512-8601
EI 1840-4812
J9 BOSNIAN J BASIC MED
JI Bosnian J. Basic Med. Sci.
PY 2022
VL 22
IS 3
BP 315
EP 325
DI 10.17305/bjbms.2021.6323
PG 11
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 2E6GS
UT WOS:000812325700002
PM 34761734
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Zhou, ZW
   Wang, D
   Xu, XY
   Dai, J
   Lao, GJ
   Zhang, SL
   Xu, XF
   Dinnyes, A
   Xiong, YL
   Sun, Q
AF Zhou, Zhiwei
   Wang, Dan
   Xu, Xinyi
   Dai, Jin
   Lao, Guangjie
   Zhang, Senlin
   Xu, Xiaofang
   Dinnyes, Andras
   Xiong, Youling
   Sun, Qun
TI Myofibrillar protein-chlorogenic acid complexes ameliorate glucose
   metabolism via modulating gut microbiota in a type 2 diabetic rat model
SO FOOD CHEMISTRY
LA English
DT Article
DE Protein-polyphenol complexes; Type 2 diabetes; Intestinal barrier; Gut
   microbiota; Intestinal metabolites
ID ANTIOXIDANT ACTIVITY; BETA-LACTOGLOBULIN; BIOACCESSIBILITY; METFORMIN;
   IMPACT
AB Growing evidence suggests that polyphenols could mitigate type 2 diabetes mellitus (T2DM). The glucose-regulatory effects of protein-bound polyphenols, however, have been rarely studied. In this study, macro-genomic and metabolomic analyses were applied to investigate the modulation of myofibrillar protein-chlorogenic acid (MP-CGA) complexes on T2DM rats from the gut microbiota perspective. Results showed that MP-CGA improved hyperglycemia and hyperlipidemia, decreased intestinal inflammation, and reduced intestinal barrier injury. MP-CGA reconstructed gut microbiota in T2DM rats, elevating the abundance of pro-biotics Bacteroides, Akkermansia, and Parabacteroides while suppressing opportunistic pathogens Enterococcus and Staphylococcus. MP-CGA significantly elevated the concentrations of intestinal metabolites like butyric acid that positively regulate T2DM and reduced the secondary bile acids contents. Therefore, MP-CGA modulated the gut microbiota and related metabolites to maintain stable blood glucose in T2DM rats, providing new insights into the application of protein-polyphenol complexes in foods.
C1 [Zhou, Zhiwei; Xu, Xinyi; Dai, Jin; Lao, Guangjie; Xu, Xiaofang; Dinnyes, Andras; Sun, Qun] Sichuan Univ, Coll Life Sci, Key Lab Bioresources & Ecoenvironm, Minist Educ, Chengdu 610064, Sichuan, Peoples R China.
   [Wang, Dan] Chengdu Med Coll, Sch Biomed Sci & Technol, Chengdu 610500, Sichuan, Peoples R China.
   [Zhang, Senlin] Sichuan Univ, Dept Food Engn, Chengdu 610064, Sichuan, Peoples R China.
   [Dinnyes, Andras] BioTalentum Ltd, Aulich Lajos Str 26, H-2100 Godollo, Hungary.
   [Dinnyes, Andras] Univ Szeged, Dept Cell Biol & Mol Med, H-6720 Szeged, Hungary.
   [Xiong, Youling] Univ Kentucky, Dept Anim & Food Sci, Lexington, KY 40546 USA.
C3 Sichuan University; Chengdu Medical College; Sichuan University;
   BioTalentum Ltd; Szeged University; University of Kentucky
RP Sun, Q (通讯作者)，Sichuan Univ, Coll Life Sci, Key Lab Bioresources & Ecoenvironm, Minist Educ, Chengdu 610064, Sichuan, Peoples R China.
EM qunsun@scu.edu.cn
FU National Key Research and Develop- ment Projects; International Research
   and Devel- opment Program of Sichuan; Sichuan Regional Innovation
   Cooperation Project;  [2019YFE0103800];  [2021YFH0060];  [2021YFH0072]; 
   [2022YFQ0100]
FX This work was supported by National Key Research and Develop- ment
   Projects (2019YFE0103800) , International Research and Devel- opment
   Program of Sichuan (2021YFH0060, 2021YFH0072) and Sichuan Regional
   Innovation Cooperation Project (2022YFQ0100) .
CR Airhart S, 2016, J CLIN ENDOCR METAB, V101, P504, DOI 10.1210/jc.2015-3292
   Athyros VG, 2018, HORM-INT J ENDOCRINO, V17, P61, DOI 10.1007/s42000-018-0014-8
   Brunkwall L, 2017, DIABETOLOGIA, V60, P943, DOI 10.1007/s00125-017-4278-3
   Cao YG, 2015, FOOD CHEM, V180, P235, DOI 10.1016/j.foodchem.2015.02.036
   Di Lorenzo C, 2021, NUTRIENTS, V13, DOI 10.3390/nu13010273
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Fouhy F, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-09252-4
   Guasch-Ferre M, 2020, AM J CLIN NUTR, V111, P835, DOI [10.1093/ajcn/ngaa016, 10.1093/ajcn/nqaa016]
   Guo AQ, 2021, COMPR REV FOOD SCI F, V20, P2801, DOI 10.1111/1541-4337.12733
   Hoskin RT, 2019, FOOD CHEM, V280, P187, DOI 10.1016/j.foodchem.2018.12.046
   Hunyadi A, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0050619
   Jiang J, 2018, FOOD CHEM, V268, P334, DOI 10.1016/j.foodchem.2018.06.015
   Lamothe S, 2016, FOOD FUNCT, V7, P1634, DOI [10.1039/c5fo01287b, 10.1039/C5FO01287B]
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Lee H, 2018, GUT MICROBES, V9, P155, DOI 10.1080/19490976.2017.1405209
   Li D, 2022, J FOOD SCI, V87, P1257, DOI 10.1111/1750-3841.16062
   Li DT, 2021, MICROBIOME, V9, DOI 10.1186/s40168-021-01028-7
   Li WR, 2020, DIABETES VASC DIS RE, V17, DOI 10.1177/1479164120966998
   Liu YP, 2022, INT J BIOL MACROMOL, V201, P616, DOI 10.1016/j.ijbiomac.2022.01.102
   Madiraju AK, 2018, NAT MED, V24, P1384, DOI 10.1038/s41591-018-0125-4
   Makishima M, 1999, SCIENCE, V284, P1362, DOI 10.1126/science.284.5418.1362
   Mandaliya DK, 2019, PANCREATOLOGY, V19, P280, DOI 10.1016/j.pan.2019.01.021
   Naveed M, 2018, BIOMED PHARMACOTHER, V97, P67, DOI 10.1016/j.biopha.2017.10.064
   Newsholme P, 2007, BIOCHEM SOC T, V35, P1180, DOI 10.1042/BST0351180
   Park D, 2007, FOOD CHEM, V101, P1239, DOI 10.1016/j.foodchem.2006.03.028
   Pascale A, 2019, CURR OPIN PHARMACOL, V49, P1, DOI 10.1016/j.coph.2019.03.011
   Ribnicky DM, 2014, FOOD CHEM, V142, P349, DOI 10.1016/j.foodchem.2013.07.073
   Rohn S., 2019, ENCY FOOD CHEM, P544, DOI DOI 10.1016/B978-0-08-100596-5.21489-3
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Singh AK, 2021, COMPUT BIOL MED, V134, DOI 10.1016/j.compbiomed.2021.104462
   Sun CD, 2020, FOOD FRONTIERS, V1, P18, DOI 10.1002/fft2.15
   von Staszewski M, 2012, J FUNCT FOODS, V4, P800, DOI 10.1016/j.jff.2012.05.008
   Williams R, 2020, DIABETES RES CLIN PR, V162, DOI 10.1016/j.diabres.2020.108072
   Wu XL, 2011, SPECTROCHIM ACTA A, V82, P164, DOI 10.1016/j.saa.2011.07.028
   Yang MM, 2020, FOOD FRONTIERS, V1, P398, DOI 10.1002/fft2.49
   Ye XW, 2022, FRONT IMMUNOL, V13, DOI 10.3389/fimmu.2022.903526
   Yin CY, 2020, J FOOD BIOCHEM, V44, DOI 10.1111/jfbc.13380
   Yuan Y, 2019, J AGR FOOD CHEM, V67, P12472, DOI 10.1021/acs.jafc.9b05118
   Zagury Y, 2019, J FUNCT FOODS, V52, P121, DOI 10.1016/j.jff.2018.10.025
   Zhang QZ, 2021, CRIT REV FOOD SCI, V61, P3589, DOI 10.1080/10408398.2020.1803199
NR 40
TC 1
Z9 1
U1 28
U2 28
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0308-8146
EI 1873-7072
J9 FOOD CHEM
JI Food Chem.
PD MAY 30
PY 2023
VL 409
AR 135195
DI 10.1016/j.foodchem.2022.135195
EA DEC 2022
PG 13
WC Chemistry, Applied; Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Food Science & Technology; Nutrition & Dietetics
GA 7S3LH
UT WOS:000910657400001
PM 36571901
DA 2023-06-08
ER

PT J
AU Ghosh, P
AF Ghosh, Pradipta
TI The stress polarity pathway: AMPK 'GIV'-es protection against metabolic
   insults
SO AGING-US
LA English
DT Article
DE LKB1; AMP-kinase; epithelial tight junctions; gut barrier; metabolic
   syndrome; heterotrimeric G proteins; energetic stress
ID ACTIVATED PROTEIN-KINASE; CYTOSOLIC 3-HYDROXY-3-METHYLGLUTARYL COENZYME;
   INTESTINAL EPITHELIAL BARRIER; IRRITABLE-BOWEL-SYNDROME; CACO-2 CELL
   MONOLAYERS; CHRONIC HEART-FAILURE; GUT MICROBIOTA; RAT-LIVER; TIGHT
   JUNCTIONS; AKKERMANSIA-MUCINIPHILA
AB Loss of cell polarity impairs organ development and function; it can also serve as one of the first triggers for oncogenesis. In 2006-2007 two groups simultaneously reported the existence of a special pathway for maintaining epithelial polarity in the face of environmental stressors. In this pathway, AMPK, a key sensor of metabolic stress stabilizes tight junctions, preserves cell polarity, and thereby, maintains epithelial barrier functions. Accumulating evidence since has shown that pharmacologic activation of AMPK by Metformin protects the epithelial barrier against multiple environmental and pathological stressful states and suppresses tumorigenesis. How AMPK protects the epithelium remained unknown until recently Aznar et al. identified GIV/Girdin as a novel effector of AMPK at the cell-cell junctions; phosphorylation of GIV at a single site by AMPK appears to be both necessary and sufficient for strengthening tight junctions and preserving cell polarity and epithelial barrier function in the face of energetic stress. Here we review the fundamentals of this specialized signaling pathway that buttresses cell-cell junctions against stress-induced collapse and discuss its pathophysiologic relevance in the context of a variety of diseases, including cancers, diabetes, aging, and the growing list of beneficial effects of the AMPK-activator, Metformin.
C1 [Ghosh, Pradipta] Univ Calif, Dept Med & Cellular & Mol Med, San Diego, CA 92093 USA.
C3 University of California System; University of California San Diego
RP Ghosh, P (通讯作者)，Univ Calif, Dept Med & Cellular & Mol Med, San Diego, CA 92093 USA.
EM prghosh@ucsd.edu
FU NIH [R01CA160911, R01CA100768, DK099226]
FX This work was funded by NIH (R01CA160911, R01CA100768 and DK099226) to
   P.G.
CR Alam MZ, 2014, CNS NEUROL DISORD-DR, V13, P383, DOI 10.2174/18715273113126660151
   Aznar N, 2016, ELIFE, V5, DOI 10.7554/eLife.20795
   Barbara G, 2006, AM J GASTROENTEROL, V101, P1295, DOI 10.1038/ajg2006242
   Barzilai N, 2016, CELL METAB, V23, P1060, DOI 10.1016/j.cmet.2016.05.011
   Bauer PV, 2016, J ENDOCRINOL, V230, pR95, DOI 10.1530/JOE-16-0056
   Bhandari D, 2015, P NATL ACAD SCI USA, V112, pE4874, DOI 10.1073/pnas.1514157112
   Bischoff SC, 2014, BMC GASTROENTEROL, V14, DOI 10.1186/s12876-014-0189-7
   Buscarinu MC, MULT SCLER
   Buse JB, 2016, DIABETES CARE, V39, P198, DOI 10.2337/dc15-0488
   Camilleri M, 2007, NEUROGASTROENT MOTIL, V19, P545, DOI 10.1111/j.1365-2982.2007.00925.x
   Cani PD, 2008, PATHOL BIOL, V56, P305, DOI 10.1016/j.patbio.2007.09.008
   Cani PD, 2009, GUT, V58, P1091, DOI 10.1136/gut.2008.165886
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   Cani PD, 2012, GUT MICROBES, V3, P279, DOI 10.4161/gmic.19625
   Cantelmo AR, 2016, CANCER CELL, V30, P968, DOI 10.1016/j.ccell.2016.10.006
   Castanares-Zapatero D, 2013, CRIT CARE MED, V41, pE411, DOI 10.1097/CCM.0b013e31829866dc
   Clairembault T, 2015, ACTA NEUROPATHOL COM, V3, DOI 10.1186/s40478-015-0196-0
   Dambroise E, 2016, SCI REP-UK, V6, DOI 10.1038/srep23523
   Ducommun S, 2015, CELL SIGNAL, V27, P978, DOI 10.1016/j.cellsig.2015.02.008
   EASOM RA, 1984, BIOCHEM J, V220, P739, DOI 10.1042/bj2200739
   EASOM RA, 1984, BIOCHEM J, V220, P733, DOI 10.1042/bj2200733
   Escobedo G, 2014, REV INVEST CLIN, V66, P450
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Farbood Y, 2015, MICROCIRCULATION, V22, P534, DOI 10.1111/micc.12224
   FERRER A, 1985, BIOCHEM BIOPH RES CO, V132, P497, DOI 10.1016/0006-291X(85)91161-1
   Garnett JP, 2013, THORAX, V68, P835, DOI 10.1136/thoraxjnl-2012-203178
   Ghosh P, 2016, CLIN CANCER RES, V22, P3488, DOI 10.1158/1078-0432.CCR-15-2290
   Ghosh P, 2010, MOL BIOL CELL, V21, P2338, DOI 10.1091/mbc.E10-01-0028
   Gummesson A, 2011, OBESITY, V19, P2280, DOI 10.1038/oby.2011.251
   Haack T, 2013, BIOL OPEN, V2, P1313, DOI 10.1242/bio.20134671
   Hardie DG, 2016, TRENDS CELL BIOL, V26, P190, DOI 10.1016/j.tcb.2015.10.013
   HARWOOD HJ, 1984, J BIOL CHEM, V259, P2810
   Hatakeyama M, 2008, ONCOGENE, V27, P7047, DOI 10.1038/onc.2008.353
   Hatakeyama M, 2014, CELL HOST MICROBE, V15, P306, DOI 10.1016/j.chom.2014.02.008
   Hawley Simon A, 2003, J Biol, V2, P28, DOI 10.1186/1475-4924-2-28
   Herms A, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms8176
   Hezel AF, 2008, ONCOGENE, V27, P6908, DOI 10.1038/onc.2008.342
   Hezel AF, 2008, MOL CELL BIOL, V28, P2414, DOI 10.1128/MCB.01621-07
   Hong SP, 2003, P NATL ACAD SCI USA, V100, P8839, DOI 10.1073/pnas.1533136100
   Houssin E, 2015, DEVELOPMENT, V142, P1777, DOI 10.1242/dev.122002
   Ichimiya H, 2015, BIOCHEM BIOPH RES CO, V461, P260, DOI 10.1016/j.bbrc.2015.04.012
   Jian MY, 2013, AM J PHYSIOL-LUNG C, V305, pL844, DOI 10.1152/ajplung.00173.2013
   Kaplan NA, 2009, GENETICS, V183, P897, DOI 10.1534/genetics.109.108878
   KATZ D, 1987, DIGEST DIS SCI, V32, P285, DOI 10.1007/BF01297055
   Kourelis TV, 2012, MED ONCOL, V29, P1314, DOI 10.1007/s12032-011-9846-7
   Lee JH, 2007, NATURE, V447, P1017, DOI 10.1038/nature05828
   Lee SY, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0135858
   Tran L, 2013, J GERONTOL A-BIOL, V68, P1045, DOI 10.1093/gerona/glt106
   Li J, 2016, CIRCULATION, V133, P2434, DOI 10.1161/CIRCULATIONAHA.115.019645
   Liu YQ, 2014, J NEUROINFLAMM, V11, DOI 10.1186/s12974-014-0177-4
   Lizcano JM, 2004, EMBO J, V23, P833, DOI 10.1038/sj.emboj.7600110
   Marin TL, 2017, SCI SIGNAL, V10, DOI 10.1126/scisignal.aaf7478
   Martin-Belmonte F, 2012, NAT REV CANCER, V12, P23, DOI 10.1038/nrc3169
   McCreight LJ, 2016, DIABETOLOGIA, V59, P426, DOI 10.1007/s00125-015-3844-9
   Mirouse V, 2013, J CELL BIOL, V203, P373, DOI 10.1083/jcb.20070205310112013r
   Moon S, 2014, SCI REP-UK, V4, DOI 10.1038/srep04376
   Muccioli GG, 2010, MOL SYST BIOL, V6, DOI 10.1038/msb.2010.46
   MUNDAY MR, 1988, EUR J BIOCHEM, V175, P331, DOI 10.1111/j.1432-1033.1988.tb14201.x
   Nakano A, 2010, NAT CELL BIOL, V12, P583, DOI 10.1038/ncb2060
   Nogales E, 1999, CELL, V96, P79, DOI 10.1016/S0092-8674(00)80961-7
   Nogales E, 1998, NATURE, V391, P199, DOI 10.1038/34465
   Nouri M, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0106335
   Ohara K, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0036681
   Park HY, 2015, BIOSCI BIOTECH BIOCH, V79, P130, DOI 10.1080/09168451.2014.951027
   Patkee WRA, 2016, J CELL MOL MED, V20, P758, DOI 10.1111/jcmm.12784
   Peng LY, 2009, J NUTR, V139, P1619, DOI 10.3945/jn.109.104638
   Pryor R, 2015, BIOCHEM J, V471, P307, DOI 10.1042/BJ20150497
   Rera M, 2012, P NATL ACAD SCI USA, V109, P21528, DOI 10.1073/pnas.1215849110
   Ross FA, 2016, FEBS J, V283, P2987, DOI 10.1111/febs.13698
   Samsam M, 2014, WORLD J GASTROENTERO, V20, P9942, DOI 10.3748/wjg.v20.i29.9942
   Sandek A, 2008, CURR OPIN CLIN NUTR, V11, P632, DOI 10.1097/MCO.0b013e32830a4c6e
   Sandek A, 2007, J AM COLL CARDIOL, V50, P1561, DOI 10.1016/j.jacc.2007.07.016
   Sandek A, 2012, INT J CARDIOL, V157, P80, DOI 10.1016/j.ijcard.2010.12.016
   Sasaki K, 2015, J CELL SCI, V128, P2244, DOI 10.1242/jcs.160879
   Seo-Mayer PW, 2011, AM J PHYSIOL-RENAL, V301, pF1346, DOI 10.1152/ajprenal.00420.2010
   Shackelford DB, 2009, NAT REV CANCER, V9, P563, DOI 10.1038/nrc2676
   Shaw RJ, 2005, SCIENCE, V310, P1642, DOI 10.1126/science.1120781
   Shaw RJ, 2004, P NATL ACAD SCI USA, V101, P3329, DOI 10.1073/pnas.0308061100
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Soares H, 2014, GENES NUTR, V9, DOI 10.1007/s12263-013-0371-5
   Spruss A, 2012, LAB INVEST, V92, P1020, DOI 10.1038/labinvest.2012.75
   St Johnston D, 2011, CURR OPIN CELL BIOL, V23, P540, DOI 10.1016/j.ceb.2011.07.005
   St Johnston D, 2010, CELL, V141, P757, DOI 10.1016/j.cell.2010.05.011
   Takata F, 2013, BIOCHEM BIOPH RES CO, V433, P586, DOI 10.1016/j.bbrc.2013.03.036
   Tang XX, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0012343
   Tricoire H, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0141920
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Valentini L, 2014, PHYSIOL REP, V2, DOI [10.14814/phy2.281, 10.1002/phy2.281]
   van De Sande MMH, 2014, NUTR RES REV, V27, P199, DOI 10.1017/S0954422414000110
   van der Velden YU, 2011, AGING-US, V3, P363, DOI 10.18632/aging.100319
   van der Velden YU, 2011, P NATL ACAD SCI USA, V108, P4358, DOI 10.1073/pnas.1010210108
   Wang B, 2016, J NUTR, V146, P501, DOI 10.3945/jn.115.224857
   Wang CH, 2014, MOL CLIN ONCOL, V2, P425, DOI 10.3892/mco.2014.265
   Wodarz A, 2007, NAT CELL BIOL, V9, P1016, DOI 10.1038/ncb433
   Woods A, 2003, CURR BIOL, V13, P2004, DOI 10.1016/j.cub.2003.10.031
   Wu T, 2016, EXPERT REV GASTROENT, P1
   Xue YS, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0168670
   Yacyshyn B, 1996, DIGEST DIS SCI, V41, P2493, DOI 10.1007/BF02100148
   Yan XP, 2011, TRANSPL P, V43, P3604, DOI 10.1016/j.transproceed.2011.10.045
   Yano T, 2013, J CELL BIOL, V203, P605, DOI 10.1083/jcb.201304194
   Zhang L, 2006, P NATL ACAD SCI USA, V103, P17272, DOI 10.1073/pnas.0608531103
   Zhang L, 2011, J BIOL CHEM, V286, P16879, DOI 10.1074/jbc.M110.186932
   Zhao B, 2016, AM J TRANSL RES, V8, P3351
   Zheng B, 2007, P NATL ACAD SCI USA, V104, P819, DOI 10.1073/pnas.0610157104
   Zhou ZY, 2016, ACTA PHARMACOL SIN, V37, P1063, DOI 10.1038/aps.2016.21
NR 105
TC 7
Z9 8
U1 0
U2 8
PU IMPACT JOURNALS LLC
PI ORCHARD PARK
PA 6666 E QUAKER ST, STE 1, ORCHARD PARK, NY 14127 USA
SN 1945-4589
J9 AGING-US
JI Aging-US
PD FEB
PY 2017
VL 9
IS 2
BP 303
EP 314
DI 10.18632/aging.101179
PG 12
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Geriatrics & Gerontology
GA EO7TH
UT WOS:000396892500004
PM 28209925
OA gold, Green Submitted, Green Published
DA 2023-06-08
ER

PT J
AU Sanegre, S
   Lucantoni, F
   Burgos-Panadero, R
   de La Cruz-merino, L
   Noguera, R
   Naranjo, TA
AF Sanegre, Sabina
   Lucantoni, Federico
   Burgos-Panadero, Rebeca
   de La Cruz-merino, Luis
   Noguera, Rosa
   Alvaro Naranjo, Tomas
TI Integrating the Tumor Microenvironment into Cancer Therapy
SO CANCERS
LA English
DT Review
DE immune therapy; metabolism; microbiota; biomarker discovery; prognostic
   tools; vitamin D3; stromal reprogramming; mitochondria;
   mechanotransduction; metformin
ID B-CELL ACTIVATION; GUT-MICROBIOME; BREAST-CANCER; MESENCHYMAL
   TRANSITION; PERINEURAL INVASION; MECHANICAL FORCES; PANCREATIC-CANCER;
   PROGNOSTIC IMPACT; NERVOUS-SYSTEM; CURCUMIN
AB Tumor progression is mediated by reciprocal interaction between tumor cells and their surrounding tumor microenvironment (TME), which among other factors encompasses the extracellular milieu, immune cells, fibroblasts, and the vascular system. However, the complexity of cancer goes beyond the local interaction of tumor cells with their microenvironment. We are on the path to understanding cancer from a systemic viewpoint where the host macroenvironment also plays a crucial role in determining tumor progression. Indeed, growing evidence is emerging on the impact of the gut microbiota, metabolism, biomechanics, and the neuroimmunological axis on cancer. Thus, external factors capable of influencing the entire body system, such as emotional stress, surgery, or psychosocial factors, must be taken into consideration for enhanced management and treatment of cancer patients. In this article, we review prognostic and predictive biomarkers, as well as their potential evaluation and quantitative analysis. Our overarching aim is to open up new fields of study and intervention possibilities, within the framework of an integral vision of cancer as a functional tissue with the capacity to respond to different non-cytotoxic factors, hormonal, immunological, and mechanical forces, and others inducing stroma and tumor reprogramming.
C1 [Sanegre, Sabina; Lucantoni, Federico; Burgos-Panadero, Rebeca; Noguera, Rosa] Univ Valencia, INCLIVA Biomed Hlth Res Inst, Med Sch, Dept Pathol, Valencia 46010, Spain.
   [Burgos-Panadero, Rebeca; Noguera, Rosa; Alvaro Naranjo, Tomas] Inst Salud Carlos III, Ctr Invest Biomed Red Canc CIBERONC, Low Prevalence Tumors, Madrid 28029, Spain.
   [de La Cruz-merino, Luis] Hosp Univ Virgen Macarena, Dept Oncol, Seville 41009, Spain.
   [Alvaro Naranjo, Tomas] Hosp Tortosa Verge Cinta, Catalan Inst Hlth, Inst Invest Sanitaria Pere Virgili IISPV, Dept Pathol, Tortosa 43500, Spain.
   [Alvaro Naranjo, Tomas] Rovira & Virgili Univ, Med Sch, Dept Morphol Sci, Reus 43201, Spain.
C3 University of Valencia; CIBER - Centro de Investigacion Biomedica en
   Red; CIBERONC; Instituto de Salud Carlos III; Hospital Universitario
   Virgen Macarena; Universitat Rovira i Virgili; Institut d'Investigacio
   Sanitaria Pere Virgili (IISPV); Universitat Rovira i Virgili
RP Noguera, R (通讯作者)，Univ Valencia, INCLIVA Biomed Hlth Res Inst, Med Sch, Dept Pathol, Valencia 46010, Spain.; Noguera, R; Naranjo, TA (通讯作者)，Inst Salud Carlos III, Ctr Invest Biomed Red Canc CIBERONC, Low Prevalence Tumors, Madrid 28029, Spain.; Naranjo, TA (通讯作者)，Hosp Tortosa Verge Cinta, Catalan Inst Hlth, Inst Invest Sanitaria Pere Virgili IISPV, Dept Pathol, Tortosa 43500, Spain.; Naranjo, TA (通讯作者)，Rovira & Virgili Univ, Med Sch, Dept Morphol Sci, Reus 43201, Spain.
EM ssanegre@incliva.es; lucantoni.federico@hotmail.it;
   reburpa@alumni.uv.es; ldelacruzmerino@gmail.com; rnoguera@uv.es;
   talvaro.ebre.ics@gencat.cat
RI de la Cruz-Merino, Luis/K-8633-2017; lucantoni, federico/I-9135-2017;
   Sanegre, Sabina/HHM-9811-2022
OI de la Cruz-Merino, Luis/0000-0002-5333-0535; lucantoni,
   federico/0000-0001-5173-7836; Sanegre, Sabina/0000-0003-0271-478X;
   BURGOS PANADERO, REBECA/0000-0003-0811-2675
FU ISCIII (FIS); FEDER (European Regional Development Fund) [PI17/01558];
   CIBERONC [CB16/12/00484]; Fundacion Cientifica de la Asociacion Espanola
   contra el Cancer [FAECC2015/006]; NEN Association (Nico contra el cancer
   infantil) [2017-PVR00157]
FX This work was supported by grants from ISCIII (FIS) and FEDER (European
   Regional Development Fund) PI17/01558; CIBERONC (contract
   CB16/12/00484); Fundacion Cientifica de la Asociacion Espanola contra el
   Cancer (FAECC2015/006) and NEN Association (Nico contra el cancer
   infantil 2017-PVR00157). The funders had no involvement in the research
   process nor in the preparation and submission of the article.
CR Ackerman SE, 2017, CURR OBES REP, V6, P195, DOI 10.1007/s13679-017-0263-x
   Adachi K, 2018, J GASTROENTEROL, V53, P999, DOI 10.1007/s00535-018-1492-9
   Aerts HJWL, 2014, NAT COMMUN, V5, DOI 10.1038/ncomms5006
   Aggarwal S, 2006, MOL PHARMACOL, V69, P195, DOI 10.1124/mol.105.017400
   Ahsan A, 2016, ADV EXP MED BIOL, V893, P137, DOI 10.1007/978-3-319-24223-1_7
   Alvaro T, 2010, J BIOMED BIOTECHNOL, DOI 10.1155/2010/846872
   Arese M, 2018, ANN TRANSL MED, V6, DOI 10.21037/atm.2018.01.01
   Balkwill FR, 2012, J CELL SCI, V125, P5591, DOI 10.1242/jcs.116392
   Behren A, 2019, FRONT ONCOL, V9, DOI 10.3389/fonc.2019.00276
   Binnewies M, 2018, NAT MED, V24, P541, DOI 10.1038/s41591-018-0014-x
   Bisson MA, 2009, J HAND SURG-AM, V34A, P1102, DOI 10.1016/j.jhsa.2009.02.008
   Blank CU, 2016, SCIENCE, V352, P658, DOI 10.1126/science.aaf2834
   Bollyky PL, 2009, J LEUKOCYTE BIOL, V86, P567, DOI 10.1189/jlb.0109001
   Brabletz T, 2018, NAT REV CANCER, V18, P128, DOI 10.1038/nrc.2017.118
   Burgos-Panadero R, 2019, CANCER LETT, V461, P112, DOI 10.1016/j.canlet.2019.07.010
   Burgos-Panadero R, 2019, BMC CANCER, V19, DOI 10.1186/s12885-019-5693-2
   Campanella G, 2019, NAT MED, V25, P1301, DOI 10.1038/s41591-019-0508-1
   Carmona-Fontaine C, 2017, P NATL ACAD SCI USA, V114, P2934, DOI 10.1073/pnas.1700600114
   Castermans K, 2007, BBA-REV CANCER, V1776, P160, DOI 10.1016/j.bbcan.2007.07.005
   Chang CH, 2015, CELL, V162, P1229, DOI 10.1016/j.cell.2015.08.016
   Chanmee T, 2016, CANCER LETT, V375, P20, DOI 10.1016/j.canlet.2016.02.031
   Chen LP, 2013, NAT REV IMMUNOL, V13, P227, DOI 10.1038/nri3405
   Chen MM, 2017, ONCOTARGET, V8, P45759, DOI 10.18632/oncotarget.17404
   Chen XY, 2016, ONCOTARGETS THER, V9, P3595, DOI 10.2147/OTT.S102356
   Cheng AL, 2001, ANTICANCER RES, V21, P2895
   Chiffoleau E, 2018, FRONT IMMUNOL, V9, DOI 10.3389/fimmu.2018.00227
   Choudhury AR, 2019, CANCER MICROENVIRON, V12, P17, DOI 10.1007/s12307-019-00222-4
   Chung AS, 2013, NAT MED, V19, P1114, DOI 10.1038/nm.3291
   Cole SW, 2015, NAT REV CANCER, V15, P563, DOI 10.1038/nrc3978
   Cormie P, 2017, EPIDEMIOL REV, V39, P71, DOI 10.1093/epirev/mxx007
   Croteau Etienne, 2016, Biomark Cancer, V8, P61, DOI 10.4137/BIC.S27483
   Curry JM, 2018, FRONT ONCOL, V8, DOI 10.3389/fonc.2018.00436
   D'Alterio C, 2020, SEMIN CANCER BIOL, V60, P351, DOI 10.1016/j.semcancer.2019.08.019
   Dang TT, 2011, CANCER RES, V71, P6857, DOI 10.1158/0008-5472.CAN-11-1818
   Darling AL, 2007, PHYS MED BIOL, V52, P4121, DOI 10.1088/0031-9155/52/14/007
   Deborde S, 2016, J CLIN INVEST, V126, P1538, DOI 10.1172/JCI82658
   deLeeuw RJ, 2012, CLIN CANCER RES, V18, P3022, DOI 10.1158/1078-0432.CCR-11-3216
   Deng J, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0088907
   Deng S, 2019, CANCER-AM CANCER SOC, V125, P1228, DOI 10.1002/cncr.31978
   Dong LF, 2017, ELIFE, V6, DOI 10.7554/eLife.22187
   Drak Alsibai K., 2018, SIGNIFICANCE TUMOR M, DOI [10.5772/intechopen.72648, DOI 10.5772/INTECHOPEN.72648]
   Dudas J, 2013, EXP CELL RES, V319, P800, DOI 10.1016/j.yexcr.2012.12.001
   Edin S, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-56441-8
   Eng JWL, 2014, CANCER IMMUNOL IMMUN, V63, P1115, DOI 10.1007/s00262-014-1617-9
   Entschladen F, 2004, LANCET ONCOL, V5, P254, DOI 10.1016/S1470-2045(04)01431-7
   Escors D, 2018, SIGNAL TRANSDUCT TAR, V3, DOI 10.1038/s41392-018-0022-9
   Faes S, 2016, ONCOTARGET, V7, P86026, DOI 10.18632/oncotarget.13323
   Faulkner S, 2019, CANCER DISCOV, V9, P702, DOI 10.1158/2159-8290.CD-18-1398
   Ferreira LMR, 2012, ONCOGENE, V31, P3999, DOI 10.1038/onc.2011.576
   Fitzgerald PJ, 2009, INT J CANCER, V124, P257, DOI 10.1002/ijc.24063
   Fridman WH, 2017, NAT REV CLIN ONCOL, V14, P717, DOI 10.1038/nrclinonc.2017.101
   Fulbright LE, 2017, PLOS PATHOG, V13, DOI 10.1371/journal.ppat.1006480
   Galluzzi L, 2019, TRENDS CELL BIOL, V29, P447, DOI 10.1016/j.tcb.2019.03.005
   Galluzzi L, 2018, SCI TRANSL MED, V10, DOI 10.1126/scitranslmed.aat7807
   Garland CF, 2014, AM J PUBLIC HEALTH, V104, pE43, DOI 10.2105/AJPH.2014.302034
   Ghosh AK, 2009, CLIN CANCER RES, V15, P1250, DOI 10.1158/1078-0432.CCR-08-1511
   Gopalakrishnan V, 2018, SCIENCE, V359, P97, DOI 10.1126/science.aan4236
   Graham DM, 2016, CURR OPIN CELL BIOL, V40, P98, DOI 10.1016/j.ceb.2016.03.006
   Hannani D, 2015, CELL RES, V25, P399, DOI [10.1038/cr.2015.28, 10.1038/cr.2015.3]
   Haznadar M, 2018, CANCER MED-US, V7, P2764, DOI 10.1002/cam4.1444
   Heiden MGV, 2009, SCIENCE, V324, P1029, DOI 10.1126/science.1160809
   Hiramatsu S, 2018, BMC IMMUNOL, V19, DOI 10.1186/s12865-018-0251-2
   Hoeppner LH, 2015, MOL ONCOL, V9, P270, DOI 10.1016/j.molonc.2014.08.008
   Hope C, 2016, BLOOD, V128, P680, DOI 10.1182/blood-2016-03-705780
   Horejs CM, 2014, P NATL ACAD SCI USA, V111, P5908, DOI 10.1073/pnas.1403139111
   Hughes PJ, 2010, LEUKEMIA RES, V34, P553, DOI 10.1016/j.leukres.2009.09.010
   Hulsen T, 2019, FRONT MED-LAUSANNE, V6, DOI 10.3389/fmed.2019.00034
   Huse M, 2017, NAT REV IMMUNOL, V17, P679, DOI 10.1038/nri.2017.74
   Idorn M, 2017, CANCER IMMUNOL IMMUN, V66, P667, DOI 10.1007/s00262-017-1985-z
   Iida N, 2013, SCIENCE, V342, P967, DOI 10.1126/science.1240527
   Islam M, 2018, CELL DEATH DIS, V9, DOI 10.1038/s41419-018-0266-x
   Iwamoto S, 2001, AM J DERMATOPATH, V23, P288, DOI 10.1097/00000372-200108000-00002
   Jobling P, 2015, CANCER RES, V75, P1777, DOI 10.1158/0008-5472.CAN-14-3180
   Kaipparettu BA, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0221671
   Kalbasi A, 2020, NAT REV IMMUNOL, V20, P25, DOI 10.1038/s41577-019-0218-4
   Kannen V, 2015, CELL SIGNAL, V27, P1781, DOI 10.1016/j.cellsig.2015.05.008
   Ko YH, 2011, CANCER BIOL THER, V12, P1085, DOI 10.4161/cbt.12.12.18671
   Kondisetty S, 2018, BIOMARK RES, V6, DOI 10.1186/s40364-018-0137-8
   Krall JA, 2018, SCI TRANSL MED, V10, DOI 10.1126/scitranslmed.aan3464
   Krause S, 2010, BMC CANCER, V10, DOI 10.1186/1471-2407-10-263
   Krieg C, 2018, NAT MED, V24, P1773, DOI 10.1038/s41591-018-0094-7
   Kunisada Y, 2017, EBIOMEDICINE, V25, P154, DOI 10.1016/j.ebiom.2017.10.009
   Kuol N, 2018, J EXP CLIN CANC RES, V37, DOI 10.1186/s13046-018-0674-x
   Kuwahara J, 2015, BIOL PHARM BULL, V38, P1410, DOI 10.1248/bpb.b15-00128
   Lee LY, 2019, CANCER MED-US, V8, P6185, DOI 10.1002/cam4.2392
   Lee TY, 2018, FRONT ONCOL, V8, DOI 10.3389/fonc.2018.00341
   Leinwand JC, 2019, NAT REV CLIN ONCOL, V16, P665, DOI 10.1038/s41571-019-0276-3
   Li JY, 2020, J BIOMECH, V100, DOI 10.1016/j.jbiomech.2019.109588
   Li LQ, 2017, NAT MATER, V16, P1164, DOI 10.1038/nmat5049
   Li P, 2015, P NATL ACAD SCI USA, V112, P4970, DOI 10.1073/pnas.1504484112
   Liang DK, 2016, BBA-REV CANCER, V1865, P111, DOI 10.1016/j.bbcan.2016.01.002
   Lim SB, 2019, NPJ PRECIS ONCOL, V3, DOI 10.1038/s41698-019-0087-0
   Lin CZ, 2019, DIGESTION, V100, P72, DOI 10.1159/000494052
   Lin KT, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0178937
   Liu F, 2019, INT J BIOL SCI, V15, P2381, DOI 10.7150/ijbs.35980
   Lu JX, 2009, CELL RES, V19, P802, DOI 10.1038/cr.2009.69
   Lyssiotis CA, 2017, TRENDS CELL BIOL, V27, P873, DOI 10.1016/j.tcb.2017.06.003
   Maalmi H, 2018, NUTRIENTS, V10, DOI 10.3390/nu10070896
   Maffini MV, 2005, AM J PATHOL, V167, P1405, DOI 10.1016/S0002-9440(10)61227-8
   Maffini MV, 2004, J CELL SCI, V117, P1495, DOI 10.1242/jcs.01000
   Mancino M, 2011, BBA-REV CANCER, V1816, P105, DOI 10.1016/j.bbcan.2011.04.005
   Martin CR, 2018, CELL MOL GASTROENTER, V6, P133, DOI 10.1016/j.jcmgh.2018.04.003
   Martino F, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.00824
   McDonald PG, 2013, BRAIN BEHAV IMMUN, V30, pS1, DOI 10.1016/j.bbi.2013.01.003
   McDonnell SL, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0199265
   McDonnell SL, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0152441
   McQuade JL, 2019, LANCET ONCOL, V20, pE77, DOI 10.1016/S1470-2045(18)30952-5
   Meng S, 2018, FRONT ONCOL, V8, DOI 10.3389/fonc.2018.00318
   Mirkin KA, 2017, CANCER BIOL THER, V18, P740, DOI 10.1080/15384047.2017.1323602
   Mittal R, 2019, J CELL PHYSIOL, V234, P8352, DOI 10.1002/jcp.27729
   Monteran L, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.01835
   Morandi A, 2017, BBA-REV CANCER, V1868, P1, DOI 10.1016/j.bbcan.2016.12.004
   Mushtaq MU, 2018, J IMMUNOTHER CANCER, V6, DOI 10.1186/s40425-018-0376-0
   Naeini MB, 2019, J CELL PHYSIOL, V234, P14743, DOI 10.1002/jcp.28262
   Neeman E, 2013, BRAIN BEHAV IMMUN, V30, pS32, DOI 10.1016/j.bbi.2012.03.006
   Ni C, 2019, J CANCER, V10, P4463, DOI 10.7150/jca.33914
   Nikitovic D, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00069
   Nissen NI, 2019, J EXP CLIN CANC RES, V38, DOI 10.1186/s13046-019-1110-6
   Noguera Rosa, 2019, Rev Esp Patol, V52, P222, DOI 10.1016/j.patol.2019.04.005
   O'Connor RS, 2012, J IMMUNOL, V189, P1330, DOI 10.4049/jimmunol.1102757
   Obradovic MMS, 2019, NATURE, V567, P540, DOI 10.1038/s41586-019-1019-4
   Ondicova K, 2010, LANCET ONCOL, V11, P596, DOI 10.1016/S1470-2045(09)70337-7
   Ooi JH, 2013, J NUTR, V143, P1679, DOI 10.3945/jn.113.180794
   Ostroumov D, 2018, CELL MOL LIFE SCI, V75, P689, DOI 10.1007/s00018-017-2686-7
   Pacella I, 2018, P NATL ACAD SCI USA, V115, pE6546, DOI 10.1073/pnas.1720113115
   Pages F, 2018, LANCET, V391, P2128, DOI 10.1016/S0140-6736(18)30789-X
   Pan M, 2016, NAT CELL BIOL, V18, P1090, DOI 10.1038/ncb3410
   Park CK, 2016, BREAST CANCER RES TR, V159, P55, DOI 10.1007/s10549-016-3929-2
   Plaks V, 2015, CELL STEM CELL, V16, P225, DOI 10.1016/j.stem.2015.02.015
   Poli A, 2009, IMMUNOLOGY, V126, P458, DOI 10.1111/j.1365-2567.2008.03027.x
   Puzanov I, 2017, J IMMUNOTHER CANCER, V5, DOI 10.1186/s40425-017-0300-z
   Rianna C, 2018, SEMIN CELL DEV BIOL, V73, P107, DOI 10.1016/j.semcdb.2017.07.022
   Riss J, 2006, CANCER RES, V66, P7216, DOI 10.1158/0008-5472.CAN-06-0040
   Rivadeneira DB, 2018, CLIN CANCER RES, V24, P2473, DOI 10.1158/1078-0432.CCR-17-0894
   Rousselle P, 2020, SEMIN CANCER BIOL, V62, P149, DOI 10.1016/j.semcancer.2019.09.026
   Routy B, 2018, SCIENCE, V359, P91, DOI 10.1126/science.aan3706
   Roy S, 2017, NAT REV CANCER, V17, P271, DOI 10.1038/nrc.2017.13
   Ruiz-Casado A, 2017, TRENDS CANCER, V3, P423, DOI 10.1016/j.trecan.2017.04.007
   Saloman JL, 2016, TRENDS NEUROSCI, V39, P880, DOI 10.1016/j.tins.2016.10.002
   Saloman JL, 2016, P NATL ACAD SCI USA, V113, P3078, DOI 10.1073/pnas.1512603113
   Sanderson JP, 2020, ONCOIMMUNOLOGY, V9, DOI 10.1080/2162402X.2019.1682381
   Sanmamed MF, 2014, CANCER J, V20, P256, DOI 10.1097/PPO.0000000000000061
   Schmidt M, 2018, BREAST CANCER RES, V20, DOI 10.1186/s13058-018-0942-x
   Schwartsburd P, 2019, FRONT ONCOL, V9, DOI 10.3389/fonc.2019.00218
   Senovilla L, 2012, ONCOIMMUNOLOGY, V1, P1323, DOI 10.4161/onci.22009
   Shanmugam MK, 2015, MOLECULES, V20, P2728, DOI 10.3390/molecules20022728
   Sharma P, 2017, CELL, V168, P707, DOI 10.1016/j.cell.2017.01.017
   Sherman MH, 2014, CELL, V159, P80, DOI 10.1016/j.cell.2014.08.007
   Shirazi MSR, 2020, J GASTROINTEST CANC, V51, P725, DOI 10.1007/s12029-019-00311-z
   Shukla A, 2004, Mech Chem Biosyst, V1, P279
   Simon T, 2017, TRENDS IMMUNOL, V38, P858, DOI 10.1016/j.it.2017.06.002
   Soto AM, 2011, BIOESSAYS, V33, P332, DOI 10.1002/bies.201100025
   Sturm G, 2019, BIOINFORMATICS, V35, pI436, DOI 10.1093/bioinformatics/btz363
   Su SC, 2018, CELL, V172, P841, DOI 10.1016/j.cell.2018.01.009
   Subrahmanyam PB, 2018, J IMMUNOTHER CANCER, V6, DOI 10.1186/s40425-018-0328-8
   Sun Chun-Hui, 2019, Chronic Dis Transl Med, V5, P178, DOI 10.1016/j.cdtm.2019.09.001
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Sun Y, 2016, CANCER LETT, V380, P205, DOI 10.1016/j.canlet.2015.07.044
   Tadeo I, 2017, PEDIATR BLOOD CANCER, V64, DOI 10.1002/pbc.26449
   Tadeo I, 2014, FRONT ONCOL, V4, DOI 10.3389/fonc.2014.00039
   Tang DC, 2019, INTEGR CANCER THER, V18, DOI 10.1177/1534735418824408
   Taube JM, 2018, MODERN PATHOL, V31, P214, DOI 10.1038/modpathol.2017.156
   Taylor SE, 2016, OPEN BIOL, V6, DOI 10.1098/rsob.160195
   Thomas AH, 2007, EXP BIOL MED, V232, P406
   Thorsson V, 2018, IMMUNITY, V48, P812, DOI [10.1016/j.immuni.2018.03.023, 10.1016/j.immuni.2019.08.004]
   Tohme S, 2017, CANCER RES, V77, P1548, DOI 10.1158/0008-5472.CAN-16-1536
   Tumeh PC, 2014, NATURE, V515, P568, DOI 10.1038/nature13954
   Van der Jeught K, 2015, ONCOTARGET, V6, P1359
   van Zijl F, 2009, FUTURE ONCOL, V5, P1169, DOI 10.2217/FON.09.91
   Vicente-Munuera P, 2020, INT J CANCER, V146, P553, DOI 10.1002/ijc.32495
   Wall M, 2018, J ORTHOP RES, V36, P605, DOI 10.1002/jor.23707
   Wallace DC, 2005, COLD SH Q B, V70, P363, DOI 10.1101/sqb.2005.70.035
   Wan ZP, 2013, J IMMUNOL, V190, P4661, DOI 10.4049/jimmunol.1202976
   WARBURG O, 1956, SCIENCE, V123, P309, DOI 10.1126/science.123.3191.309
   Wculek SK, 2020, NAT REV IMMUNOL, V20, P7, DOI 10.1038/s41577-019-0210-z
   Wegiel B, 2018, FRONT ONCOL, V8, DOI 10.3389/fonc.2018.00284
   Weidenfeld K, 2018, FRONT ONCOL, V8, DOI 10.3389/fonc.2018.00381
   Weinstein JN, 2013, NAT GENET, V45, P1113, DOI 10.1038/ng.2764
   Whiteside TL, 2013, FRONT ONCOL, V3, DOI 10.3389/fonc.2013.00107
   Wong SW, 2018, APL BIOENG, V2, DOI 10.1063/1.5025689
   Wu MX, 2018, SMALL, V14, DOI 10.1002/smll.201801131
   Xu YF, 2007, HUM MOL GENET, V16, pR14, DOI 10.1093/hmg/ddl486
   Yi M, 2018, J HEMATOL ONCOL, V11, DOI 10.1186/s13045-018-0592-6
   Yilmaz M, 2009, CANCER METAST REV, V28, P15, DOI 10.1007/s10555-008-9169-0
   Yin ZP, 2019, J EXP CLIN CANC RES, V38, DOI 10.1186/s13046-019-1409-3
   Zanotelli MR, 2018, ADV EXP MED BIOL, V1092, P91, DOI 10.1007/978-3-319-95294-9_6
   Zeng YY, 2015, EUR J IMMUNOL, V45, P1621, DOI 10.1002/eji.201444777
   Zhang CQ, 2015, CANCER PREV RES, V8, P63, DOI 10.1158/1940-6207.CAPR-14-0254
   Zhang Y, 2016, JAMA ONCOL, V2, P1403, DOI 10.1001/jamaoncol.2016.2450
   Zhao CM, 2014, SCI TRANSL MED, V6, DOI 10.1126/scitranslmed.3009569
   Zhao Wenxiu, 2017, Cancer Transl Med, V3, P87, DOI 10.4103/ctm.ctm_69_16
   Zhou ZW, 2018, FRONT ONCOL, V8, DOI 10.3389/fonc.2018.00371
   Zhu YM, 2018, CANCER MANAG RES, V10, P2475, DOI 10.2147/CMAR.S167400
   Zitvogel L, 2017, NAT REV MICROBIOL, V15, P465, DOI 10.1038/nrmicro.2017.44
   Zou WP, 2016, SCI TRANSL MED, V8, DOI 10.1126/scitranslmed.aad7118
NR 195
TC 15
Z9 16
U1 5
U2 22
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6694
J9 CANCERS
JI Cancers
PD JUN
PY 2020
VL 12
IS 6
AR 1677
DI 10.3390/cancers12061677
PG 24
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA ML2DD
UT WOS:000549282300001
PM 32599891
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Barengolts, E
   Smith, ED
AF Barengolts, Elena
   Smith, Emily Daviau
TI CONSIDERATIONS FOR GUT MICROBIOTA AND PROBIOTICS IN PATIENTS WITH
   DIABETES AMIDST THE COVID-19 PANDEMIC: A NARRATIVE REVIEW
SO ENDOCRINE PRACTICE
LA English
DT Review
ID INSULIN-RESISTANCE; HIGH-FAT; CORONAVIRUS; MICE; SUPPLEMENTATION;
   MORTALITY; PROTECTS; SYSTEM; CELLS; SIRT1
AB Objective: To review data implicating microbiota influences on Coronavirus Disease 2019 (COVID-19) in patients with diabetes.
   Methods: Primary literature review included topics: "COVID-19," "SARS," "MERS," "gut microbiota," "probiotics," "immune system," "ACE2," and "metformin."
   Results: Diabetes was prevalent (similar to 11%) among COVID-19 patients and associated with increased mortality (about 3-fold) compared to patients without diabetes. COVID-19 could be associated with worsening diabetes control and new diabetes diagnosis that could be linked to high expression of angiotensin-converting enzyme 2 (ACE2) receptors (coronavirus point of entry into the host) in the endocrine pancreas. A pre-existing gut microbiota imbalance (dysbiosis) could contribute to COVID-19-related complications in patients with diabetes. The COVID-19 virus was found in fecal samples (similar to 55%), persisted for about 5 weeks, and could be associated with diarrhea, suggesting a role for gut dysbiosis. ACE2 expressed on enterocytes and colonocytes could serve as an alternative route for acquiring COVID-19. Experimental models proposed some probiotics, including Lactobacillus casei, L. plantarum, and L. salivarius, as vectors for delivering or enhancing efficacy of anti-coronavirus vaccines. These Lactobacillus probiotics were also beneficial for diabetes. The potential mechanisms for interconnections between coronavirus, diabetes, and gut microbiota could be related to the immune system, ACE2 pathway, and metformin treatment. There were suggestions but no proof supporting probiotics benefits for COVID-19 infection.
   Conclusion: The data suggested that the host environment including the gut microbiota could play a role for COVID-19 in patients with diabetes. It is a challenge to the scientific community to investigate the beneficial potential of the gut microbiota for strengthening host defense against coronavirus in patients with diabetes.
C1 [Barengolts, Elena; Smith, Emily Daviau] Univ Illinois, Med Ctr, Dept Med, Chicago, IL 60612 USA.
   [Barengolts, Elena; Smith, Emily Daviau] Jesse Brown VA Med Ctr, Dept Med, Chicago, IL USA.
C3 University of Illinois System; University of Illinois Chicago;
   University of Illinois Chicago Hospital; US Department of Veterans
   Affairs; Veterans Health Administration (VHA); Jesse Brown VA Medical
   Center
RP Barengolts, E (通讯作者)，Univ Illinois, Med Ctr, Dept Med, Sect Endocrinol, MC 640,835 Wolcott St, Chicago, IL 60612 USA.
EM eibareng@uic.edu
CR Badawi A, 2016, INT J INFECT DIS, V49, P129, DOI 10.1016/j.ijid.2016.06.015
   Barengolts E, 2019, NUTRIENTS, V11, DOI 10.3390/nu11030671
   Barengolts E, 2016, ENDOCR PRACT, V22, P1224, DOI 10.4158/EP151157.RA
   Bradley CP, 2017, CELL HOST MICROBE, V22, P697, DOI 10.1016/j.chom.2017.10.007
   Busek P, 2015, HISTOCHEM CELL BIOL, V143, P497, DOI 10.1007/s00418-014-1292-0
   Campbell JM, 2017, AGEING RES REV, V40, P31, DOI 10.1016/j.arr.2017.08.003
   Carlos D, 2020, FRONT IMMUNOL, V11, DOI 10.3389/fimmu.2020.01265
   Caron AZ, 2014, FASEB J, V28, P1306, DOI 10.1096/fj.13-243568
   Castelli V, 2020, AGING-US, V12, P4641, DOI 10.18632/aging.102927
   Chen X, HYPERTENSION DIABETE, DOI DOI 10.1101/2020.03.22.20040774V1
   Chen XR, 2008, J IMMUNOL, V180, P138, DOI 10.4049/jimmunol.180.1.138
   Chow N, 2020, MMWR-MORBID MORTAL W, V69, P382, DOI 10.15585/mmwr.mm6913e2
   Chung JY, 2009, J MICROBIOL BIOTECHN, V19, P1401, DOI 10.4014/jmb.0904.04010
   Chung PH, 2016, J NUTR BIOCHEM, V35, P48, DOI 10.1016/j.jnutbio.2016.05.013
   Ciubotaru I, 2015, TRANSL RES, V166, P401, DOI 10.1016/j.trsl.2015.06.015
   Clarke NE, 2014, CLIN SCI, V126, P507, DOI 10.1042/CS20130291
   Cole-Jeffrey CT, 2015, J CARDIOVASC PHARM, V66, P540, DOI 10.1097/FJC.0000000000000307
   Conte L, 2020, THER ADV RESPIR DIS, V14, DOI 10.1177/1753466620937170
   Cuyas E, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00657
   d'Ettorre G, 2020, FRONT MED-LAUSANNE, V7, DOI 10.3389/fmed.2020.00389
   De Giorgi L, 2018, FRONT IMMUNOL, V9, DOI 10.3389/fimmu.2018.01752
   Dhama K, 2020, HUM VACC IMMUNOTHER, V16, P1232, DOI 10.1080/21645515.2020.1735227
   Duan YQ, 2019, CIRC RES, V125, P969, DOI 10.1161/CIRCRESAHA.119.315743
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Gomez DE, 2017, J VET INTERN MED, V31, P1884, DOI 10.1111/jvim.14811
   Gretebeck LM, 2015, CURR OPIN VIROL, V13, P123, DOI 10.1016/j.coviro.2015.06.009
   Hao QK, 2015, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD006895.pub3
   Hulston CJ, 2015, BRIT J NUTR, V113, P596, DOI 10.1017/S0007114514004097
   Ianiro G, 2020, LANCET GASTROENTEROL, V5, P430, DOI 10.1016/S2468-1253(20)30082-0
   Khalili L., 2018, IRAN BIOMED J, V23, P68, DOI [10.29252/ibj.23.1.68, DOI 10.29252/IBJ.23.1.68]
   Kim JA, 2016, IMMUNE NETW, V16, P286, DOI 10.4110/in.2016.16.5.286
   Kumar VJR, 2010, TROP ANIM HEALTH PRO, V42, P1855, DOI 10.1007/s11250-010-9648-5
   Leung WK, 2003, GASTROENTEROLOGY, V125, P1011, DOI 10.1053/S0016-5085(03)01215-0
   Liu WC, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0196511
   Maciel JF, 2019, J MED MICROBIOL, V68, P417, DOI 10.1099/jmm.0.000937
   Mak JWY, 2020, LANCET GASTROENTEROL, V5, P644, DOI 10.1016/S2468-1253(20)30122-9
   Maragkoudakis PA, 2010, INT J FOOD MICROBIOL, V141, pS91, DOI 10.1016/j.ijfoodmicro.2009.12.024
   Meazzi S, 2019, RES VET SCI, V125, P272, DOI 10.1016/j.rvsc.2019.07.003
   Mendy A, 2019, RESPIROLOGY, V24, P646, DOI 10.1111/resp.13486
   Minodier L, 2017, BMC INFECT DIS, V17, DOI 10.1186/s12879-017-2823-9
   Moher D, 2010, INT J SURG, V8, P336, DOI [10.1136/bmj.b2535, 10.1016/j.ijsu.2010.02.007, 10.1016/j.ijsu.2010.07.299, 10.1186/s13643-015-0087-2]
   Molloy EJ, 2020, PEDIATR RES, V88, P340, DOI 10.1038/s41390-020-0881-y
   Olivares M, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.01900
   Paul AEH, 2019, AUST VET J, V97, P418, DOI 10.1111/avj.12867
   Perlot T, 2013, MICROBES INFECT, V15, P866, DOI 10.1016/j.micinf.2013.08.003
   Pomie C, 2016, MOL METAB, V5, P392, DOI 10.1016/j.molmet.2016.03.004
   Pusterla N, 2018, VET J, V231, P13, DOI 10.1016/j.tvjl.2017.11.004
   Qu L, 2018, J AGR FOOD CHEM, V66, P12696, DOI 10.1021/acs.jakc.8b04874
   Sabico S, 2017, J TRANSL MED, V15, DOI 10.1186/s12967-017-1354-x
   Sato J, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-12535-9
   Servin AL, 2004, FEMS MICROBIOL REV, V28, P405, DOI 10.1016/j.femsre.2004.01.003
   Shen ZJ, 2020, CLIN INFECT DIS, V71, P713, DOI 10.1093/cid/ciaa203
   Sinclair A, 2020, DIABETES RES CLIN PR, V162, DOI 10.1016/j.diabres.2020.108078
   Su MM, 2020, RESP CARE, V65, P673, DOI 10.4187/respcare.07097
   Tan Z, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0219868
   Toshimitsu T, 2019, NUTRITION, V58, P175, DOI 10.1016/j.nut.2018.07.116
   Vilahur G, 2015, EUR J NUTR, V54, P1161, DOI 10.1007/s00394-014-0794-9
   Wang F, 2020, GASTROENTEROLOGY, V159, P367, DOI 10.1053/j.gastro.2020.03.055
   Wang G, 2017, FOOD FUNCT, V8, P3155, DOI 10.1039/c7fo00593h
   Wang XN, 2017, VIRUSES-BASEL, V9, DOI 10.3390/v9110312
   Weston S, 2019, J VIROL, V93, DOI 10.1128/JVI.00197-19
   Wieers G, 2020, FRONT CELL INFECT MI, V9, DOI 10.3389/fcimb.2019.00454
   Wu ZY, 2020, JAMA-J AM MED ASSOC, V323, P1239, DOI 10.1001/jama.2020.2648
   Xia L, 2018, VIROL J, V15, DOI 10.1186/s12985-018-1012-9
   Yang JK, 2006, DIABETIC MED, V23, P623, DOI 10.1111/j.1464-5491.2006.01861.x
   Yang JK, 2010, ACTA DIABETOL, V47, P193, DOI 10.1007/s00592-009-0109-4
   Yang WT, 2018, APPL MICROBIOL BIOT, V102, P8307, DOI 10.1007/s00253-018-9238-4
   Yeh TL, 2018, DRUG DES DEV THER, V12, P217, DOI 10.2147/DDDT.S155110
   Yi H, 2014, BMC INFECT DIS, V14, DOI 10.1186/s12879-014-0583-3
   Zhang W, 2020, EMERG MICROBES INFEC, V9, DOI 10.1080/22221751.2020.1729071
   Zhang XS, 2018, ELIFE, V7, DOI 10.7554/eLife.37816
   Zhou H, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.00125
   Zhou J, 2017, SCI ADV, V3, DOI 10.1126/sciadv.aao4966
   Zhou ZY, 2016, ACTA PHARMACOL SIN, V37, P1063, DOI 10.1038/aps.2016.21
   Zuo T, 2020, GASTROENTEROLOGY, V159, P944, DOI 10.1053/j.gastro.2020.05.048
NR 76
TC 1
Z9 1
U1 2
U2 12
PU ELSEVIER INC
PI SAN DIEGO
PA 525 B STREET, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1530-891X
EI 1934-2403
J9 ENDOCR PRACT
JI Endocr. Pract.
PD OCT
PY 2020
VL 26
IS 10
BP 1186
EP 1195
DI 10.4158/EP-2020-0336
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA OO5KJ
UT WOS:000587416900015
PM 33471720
OA Green Published
DA 2023-06-08
ER

PT J
AU Liao, XY
   Song, LY
   Zeng, BH
   Liu, BY
   Qiu, YY
   Qu, H
   Zheng, Y
   Long, M
   Zhou, HD
   Wang, Y
   Du, YX
   Xu, J
   Shen, RF
   Tong, Q
   Cai, L
   Li, X
   Guo, SD
   Yang, GY
   Zhu, ZM
   Pu, XY
   Wei, H
   Zheng, HT
AF Liao, Xiaoyu
   Song, Lingyu
   Zeng, Benhua
   Liu, Bingyao
   Qiu, Yuyang
   Qu, Hua
   Zheng, Yi
   Long, Min
   Zhou, Houdi
   Wang, Yuan
   Du, Yingxuan
   Xu, Jing
   Shen, Rufei
   Tong, Qiang
   Cai, Leigin
   Li, Xing
   Guo, Shaodong
   Yang, Gangyi
   Zhu, Zhiming
   Pu, Xiaoyun
   Wei, Hong
   Zheng, Hongting
TI Alteration of gut microbiota induced by DPP-4i treatment improves
   glucose homeostasis
SO EBIOMEDICINE
LA English
DT Article
DE DPP-4i; Gut microbiota; Glucose tolerance; GF mice
ID DIPEPTIDYL PEPTIDASE-IV; GLUCAGON-LIKE PEPTIDE-1; CHAIN FATTY-ACIDS;
   INSULIN-RESISTANCE; DIABETES-MELLITUS; METFORMIN ALTERS;
   LIPID-METABOLISM; INFLAMMATION; BRAIN; INHIBITION
AB Background: Increasing evidence indicates that the gut microbiota contributes to the occurrence and development of metabolic diseases. However, little is known about the effects of commonly used antidiabetic agents on the gut microbiota. In this study, we investigated the roles of dipeptidyl peptidase-4 inhibitors (DPP-4i) and alpha-glucosidase inhibitor in modulating the gut microbiota.
   Methods: 16S-rDNA sequencing was performed to analyse the effects of DPP-4i and acarbose on the gut microbiota in mice fed a high-fat diet (HFD). Fecal microbiota transplantation (FMT) from type 2 diabetes patients to germ-free mice was performed to investigate the contribution of the altered microbiome to antidiabetic effects of the drugs. Fecal metabolomics was also analysed by untargeted and targeted GC-MS systems.
   Findings: Although DPP-4i and a-glucosidase inhibitor both altered the gut microbial composition, only the microbiome modulation of DPP-4i contributed to its hypoglycemic effect. Specifically, the changes of 68.6% genera induced by HID were rescued by DPP-4i. [MT showed that the DPP-4i-altered microbiome improved glucose tolerance in colonized mice, while acarbose did not. Moreover. DPP-4i increased the abundance of Bacteroidetes, and also promoted a functional shift in the gut microbiome, especially increasing the production of succinate.
   Interpretation: Our findings demonstrate an important effect of DPP-4i on the gut microbiota, revealing a new hypoglycemic mechanism and an additional benefit of it. Furthermore, modulating the microbial composition, and the functional shift arising from changes in the microbiome, might be a potential strategy for improving glucose homeostasis. (C) 2019 The Authors. Published by Elsevier B.V.
C1 [Liao, Xiaoyu; Song, Lingyu; Liu, Bingyao; Qiu, Yuyang; Qu, Hua; Zheng, Yi; Long, Min; Zhou, Houdi; Wang, Yuan; Du, Yingxuan; Xu, Jing; Shen, Rufei; Tong, Qiang; Cai, Leigin; Li, Xing; Zheng, Hongting] Third Mil Med Univ, Xinqiao Hosp, Translat Res Key Lab Diabet, Dept Endocrinol, Chongqing 400037, Peoples R China.
   [Zeng, Benhua; Wei, Hong] Third Mil Med Univ, Coll Basic Med Sci, Dept Lab Anim Sci, Chongqing 400037, Peoples R China.
   [Guo, Shaodong] Texas A&M Univ, Dept Nutr & Food Sci, College Stn, TX 77843 USA.
   [Yang, Gangyi] Chongqing Med Univ, Affiliated Hosp 2, Dept Endocrinol, Chongqing, Peoples R China.
   [Zhu, Zhiming] Third Mil Med Univ, Daping Hosp, Dept Hypertens & Endocrinol, Chongqing, Peoples R China.
   [Pu, Xiaoyun] Third Mil Med Univ, Xinqiao Hosp, Dept Clin Lab, Chongqing, Peoples R China.
   [Song, Lingyu] Guizhou Med Univ, Affiliated Hosp, Dept Gastroenterol, Guiyang, Guizhou, Peoples R China.
C3 Army Medical University; Army Medical University; Texas A&M University
   System; Texas A&M University College Station; Chongqing Medical
   University; Army Medical University; Army Medical University; Guizhou
   Medical University
RP Zheng, HT (通讯作者)，Third Mil Med Univ, Xinqiao Hosp, Translat Res Key Lab Diabet, Dept Endocrinol, Chongqing 400037, Peoples R China.; Wei, H (通讯作者)，Third Mil Med Univ, Coll Basic Med Sci, Dept Lab Anim Sci, Chongqing 400037, Peoples R China.
EM weihong63528@163.com; fnf7703@hotmail.com
RI Song, Lu yang/HPF-0922-2023; song, ling/GQZ-5934-2022
OI Song, Lu yang/0009-0006-5587-1630; ZHENG, YI/0000-0002-5945-4432; Li,
   Xing/0000-0001-6469-4839; Liao, Xiaoyu/0000-0001-9851-3848
FU National Natural Science Foundation of China [81700757, 81471039,
   81700714, 81770434]; National Key R&D Program of China [2017YFC1309602,
   2016YFC1101100, 2017YFD0500503, 2017YFD0501001]; Natural Science
   Foundation Project of Chongqing [cstc2014jcyjjq10006, cstc2016jcyjA0093,
   cstc2016jcyjA0518]
FX This work was supported by grants from the National Natural Science
   Foundation of China (No. 81700757, No. 81471039, No. 81700714 and No.
   81770434), the National Key R&D Program of China (No. 2017YFC1309602,
   No. 2016YFC1101100, No. 2017YFD0500503 and No. 2017YFD0501001), and the
   Natural Science Foundation Project of Chongqing (No.
   cstc2014jcyjjq10006, No. cstc2016jcyjA0093 and No. cstc2016jcyjA0518).
CR Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   Anhe FF, 2015, GUT, V64, P872, DOI 10.1136/gutjnl-2014-307142
   Backhed F, 2004, P NATL ACAD SCI USA, V101, P15718, DOI 10.1073/pnas.0407076101
   Bae EJ, 2016, ARCH PHARM RES, V39, P1114, DOI 10.1007/s12272-016-0813-x
   Bauer PV, 2018, CELL METAB, V27, P101, DOI 10.1016/j.cmet.2017.09.019
   Birnbaum Y, 2016, BMJ OPEN DIAB RES CA, V4, DOI 10.1136/bmjdrc-2016-000227
   Bruce-Keller AJ, 2018, BIOL PSYCHIAT, V83, P214, DOI 10.1016/j.biopsych.2017.08.014
   Cai DS, 2005, NAT MED, V11, P183, DOI 10.1038/nm1166
   Cani PD, 2007, DIABETOLOGIA, V50, P2374, DOI 10.1007/s00125-007-0791-0
   Carrascosa JM, 2001, DIABETES OBES METAB, V3, P240, DOI 10.1046/j.1463-1326.2001.00102.x
   Cheng SS, 2012, CIRCULATION, V125, P2222, DOI 10.1161/CIRCULATIONAHA.111.067827
   Chu HT, 2016, SCIENCE, V352, P1116, DOI 10.1126/science.aad9948
   De Vadder F, 2016, CELL METAB, V24, P151, DOI 10.1016/j.cmet.2016.06.013
   De Vadder F, 2014, CELL, V156, P84, DOI 10.1016/j.cell.2013.12.016
   dos Santos L, 2013, CIRC-HEART FAIL, V6, P1029, DOI 10.1161/CIRCHEARTFAILURE.112.000057
   Drucker DJ, 2006, LANCET, V368, P1696, DOI 10.1016/S0140-6736(06)69705-5
   Eckburg PB, 2005, SCIENCE, V308, P1635, DOI 10.1126/science.1110591
   Evans CC, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0092193
   Everard A, 2014, MBIO, V5, DOI 10.1128/mBio.01011-14
   Everard A, 2014, ISME J, V8, P2116, DOI 10.1038/ismej.2014.45
   Everard A, 2011, DIABETES, V60, P2775, DOI 10.2337/db11-0227
   Fischbach MA, 2011, CELL HOST MICROBE, V10, P336, DOI 10.1016/j.chom.2011.10.002
   Furet JP, 2010, DIABETES, V59, P3049, DOI 10.2337/db10-0253
   Gill SR, 2006, SCIENCE, V312, P1355, DOI 10.1126/science.1124234
   Grasset E, 2017, CELL METAB, V25, P1075, DOI 10.1016/j.cmet.2017.04.013
   Gu YY, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-01682-2
   Handelsman Y, 2015, ENDOCR PRACT, V21, P1, DOI [10.4158/EP15672.GL, 10.4158/EP15672.GLSUPPL]
   Hildebrandt MA, 2009, GASTROENTEROLOGY, V137, P1716, DOI 10.1053/j.gastro.2009.08.042
   Hirsh AJ, 1997, GASTROENTEROLOGY, V113, P205, DOI 10.1016/S0016-5085(97)70096-9
   Holst JJ, 1998, DIABETES, V47, P1663, DOI 10.2337/diabetes.47.11.1663
   Hwang I, 2015, FASEB J, V29, P2397, DOI 10.1096/fj.14-265983
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kim KA, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0047713
   Kim SJ, 2008, DIABETES, V57, P1331, DOI 10.2337/db07-1639
   Koh A, 2016, CELL, V165, P1332, DOI 10.1016/j.cell.2016.05.041
   Ley RE, 2005, P NATL ACAD SCI USA, V102, P11070, DOI 10.1073/pnas.0504978102
   Ley RE, 2006, NATURE, V444, P1022, DOI 10.1038/4441022a
   Long M, 2018, DIABETES, V67, P518, DOI 10.2337/db17-0934
   Lynch SV, 2016, NEW ENGL J MED, V375, P2369, DOI 10.1056/NEJMra1600266
   Maes M, 2001, MOL PSYCHIATR, V6, P475, DOI 10.1038/sj.mp.4000872
   Mentzel S, 1996, J HISTOCHEM CYTOCHEM, V44, P445, DOI 10.1177/44.5.8627002
   Moreira GV, 2018, J NUTR BIOCHEM, V62, P143, DOI 10.1016/j.jnutbio.2018.07.009
   Muegge BD, 2011, SCIENCE, V332, P970, DOI 10.1126/science.1198719
   Olivares M, 2018, DIABETOLOGIA, V61, P1838, DOI 10.1007/s00125-018-4647-6
   Org E, 2017, GENOME BIOL, V18, DOI 10.1186/s13059-017-1194-2
   Perry RJ, 2016, NATURE, V534, P213, DOI 10.1038/nature18309
   Reichardt N, 2014, ISME J, V8, P1323, DOI 10.1038/ismej.2014.14
   SCHEIFINGER CC, 1973, APPL MICROBIOL, V26, P789, DOI 10.1128/AEM.26.5.789-795.1973
   Scher JU, 2011, NAT REV RHEUMATOL, V7, P569, DOI 10.1038/nrrheum.2011.121
   Shah Z, 2011, CIRCULATION, V124, P2339, DOI 10.1161/CIRCULATIONAHA.111.041418
   Shapiro H, 2017, J DIABETES, V9, P226, DOI 10.1111/1753-0407.12501
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Soty M, 2017, CELL METAB, V25, P1231, DOI 10.1016/j.cmet.2017.04.032
   Su BL, 2015, J DIABETES, V7, P729, DOI 10.1111/1753-0407.12232
   Sung MM, 2017, DIABETES, V66, P418, DOI 10.2337/db16-0680
   Topping DL, 2001, PHYSIOL REV, V81, P1031, DOI 10.1152/physrev.2001.81.3.1031
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Wang H, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-02576-5
   Wang H, 2016, SCI TRANSL MED, V8, DOI 10.1126/scitranslmed.aad6095
   Wang L, 2016, SCI REP-UK, V6, DOI [10.1038/srep38380, 10.1038/srep33251, 10.1038/srep20004]
   Wesley UV, 2017, MOL NEUROBIOL, V54, P4973, DOI 10.1007/s12035-016-0039-4
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Xiao SM, 2014, FEMS MICROBIOL ECOL, V87, P357, DOI 10.1111/1574-6941.12228
   Xiong T, 2020, SENSOR ACTUAT B-CHEM, V304, DOI [10.1126/scitranslmed.3009124, 10.1016/j.snb.2019.127310]
   Yan XF, 2016, J DIABETES RES, V2016, DOI 10.1155/2016/2093171
   Zeng HW, 2016, J NUTR BIOCHEM, V35, P30, DOI 10.1016/j.jnutbio.2016.05.015
   Zhao L, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00233
   Zheng P, 2016, MOL PSYCHIATR, V21, P786, DOI 10.1038/mp.2016.44
   Zheng XJ, 2017, BMC BIOL, V15, DOI 10.1186/s12915-017-0462-7
NR 69
TC 46
Z9 53
U1 1
U2 31
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2352-3964
J9 EBIOMEDICINE
JI EBioMedicine
PD JUN
PY 2019
VL 44
BP 665
EP 674
DI 10.1016/j.ebiom.2019.03.057
PG 10
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA IF0LQ
UT WOS:000472768900065
PM 30922964
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Chobot, A
   Gorowska-Kowolik, K
   Sokolowska, M
   Jarosz-Chobot, P
AF Chobot, Agata
   Gorowska-Kowolik, Katarzyna
   Sokolowska, Magdalena
   Jarosz-Chobot, Przemyslawa
TI Obesity and diabetes-Not only a simple link between two epidemics
SO DIABETES-METABOLISM RESEARCH AND REVIEWS
LA English
DT Review
DE diabetes; epidemiology; insulin resistance; microbiome; obesity; type 1
   diabetes; type 2 diabetes
ID BODY-MASS INDEX; HIGH-FAT DIET; GUT MICROBIOTA; GLYCEMIC CONTROL;
   TYPE-1; MELLITUS; PROBIOTICS; METFORMIN; CHILDREN; INSULIN
AB Diabetes (DM) as well as obesity, due to their increasing incidence, were recognized as epidemic by the World Health Organization. Obesity is involved not only in the aetiopathogenesis of the most common worldwide type of DM-type 2 diabetes-but also in the development of its complications. There is also increasing scientific evidence regarding the role of obesity and overweight in type 1 diabetes. Weight gain may be considered as a complication of insulin treatment but also reveals significant pathophysiological impact on various stages of the disease. Another very important aspect related to DM as well as obesity is the microbiome, which is highly variable. The function of the gut microflora, its interaction with the whole organism, and its role in the development of obesity and type 1 diabetes as well as type 2 diabetes are still not fully understood and subject of ongoing investigations. This review presents a summary of recently published results concerning the relation of obesity/overweight and DM as well as their associations with the microbiome.
C1 [Chobot, Agata; Gorowska-Kowolik, Katarzyna] Clin Hosp 1, Dept Pediat Gastronterol & Hepatol, Zabrze, Poland.
   [Sokolowska, Magdalena] John Paul II Upper Silesian Child Hlth Ctr, Dept Pediat, Katowice, Poland.
   [Jarosz-Chobot, Przemyslawa] Med Univ Silesia, Sch Med Katowice, Dept Childrens Diabetol, Katowice, Poland.
C3 Medical University Silesia
RP Chobot, A (通讯作者)，Clin Hosp 1, 3 Go Maja 13-15, PL-41800 Zabrze, Poland.
EM agata.chobot@gmail.com
RI Chobot, przemyslawa Jarosz - Chobot Jarosz-/O-3203-2019; Chobot,
   Agata/J-2260-2016
OI Chobot, Agata/0000-0002-9622-4433; Gorowska-Kowolik,
   Katarzyna/0000-0003-2439-0931; Jarosz-Chobot,
   Przemyslawa/0000-0002-1120-0994
FU  [KNW-1-063/N/7/K]
FX The manuscript was supported by KNW-1-063/N/7/K (PJC).
CR Abbasi A, 2017, J ENDOCR SOC, V1, P524, DOI 10.1210/js.2017-00044
   Abdelghaffar S, 2009, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD006691.pub2
   Akbari V, 2016, NUTR REV, V74, P774, DOI 10.1093/nutrit/nuw039
   Al Amiri E, 2015, BMC PUBLIC HEALTH, V15, DOI 10.1186/s12889-015-2649-6
   Barlow GM, 2015, NUTR CLIN PRACT, V30, P787, DOI 10.1177/0884533615609896
   Boucher-Berry C, 2016, J DIABETES METAB DIS, V15, DOI 10.1186/s40200-016-0271-5
   Bradlow HL, 2014, HORM MOL BIOL CLIN I, V17, P53, DOI 10.1515/hmbci-2013-0063
   Burchardt P, 2016, POL ARCH MED WEWN, V126, P514, DOI 10.20452/pamw.3527
   Burchardt P, 2013, POL ARCH MED WEWN, V123, P526, DOI 10.20452/pamw.1925
   Chen J, 2014, J FOOD SCI, V79, pR442, DOI 10.1111/1750-3841.12397
   Chillaron JJ, 2014, METABOLISM, V63, P181, DOI 10.1016/j.metabol.2013.10.002
   Collier A, 2018, DIABETES OBES METAB, V20, P1965, DOI 10.1111/dom.13334
   Colosia AD, 2013, DIABET METAB SYND OB, V6, P327, DOI 10.2147/DMSO.S51325
   D'Adamo E, 2011, DIABETES CARE, V34, pS161, DOI 10.2337/dc11-s212
   de Ferranti SD, 2014, CIRCULATION, V130, P1110, DOI [10.1161/CIR.0000000000000034, 10.2337/dc14-1720]
   Deeb A, 2017, J DIABETES OBES, V4, P1, DOI DOI 10.15436/2376-0494.17.1389
   DuBose SN, 2015, J PEDIATR-US, V167, P627, DOI 10.1016/j.jpeds.2015.05.046
   Ehtisham S, 2000, DIABETIC MED, V17, P867, DOI 10.1046/j.1464-5491.2000.00409.x
   Frohlich-Reiterer EE, 2014, ARCH DIS CHILD, V99, P738, DOI 10.1136/archdischild-2013-304237
   Hannon TS, 2005, PEDIATRICS, V116, P473, DOI 10.1542/peds.2004-2536
   Hill CJ, 2013, QJM-INT J MED, V106, P933, DOI 10.1093/qjmed/hct123
   Huang Jeannie S, 2011, BMC Res Notes, V4, P29, DOI 10.1186/1756-0500-4-29
   Huxley RR, 2015, LANCET DIABETES ENDO, V3, P198, DOI 10.1016/S2213-8587(14)70248-7
   Hwang I, 2015, FASEB J, V29, P2397, DOI 10.1096/fj.14-265983
   Kasinska MA, 2015, POL ARCH MED WEWN, V125, P803, DOI 10.20452/pamw.3156
   Konrad K, 2015, PEDIATR DIABETES, V16, P529, DOI 10.1111/pedi.12203
   Lee EY, 2017, DIABETES-METAB RES, V33, DOI 10.1002/dmrr.2815
   Li CL, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000004798
   Libman IM, 2015, JAMA-J AM MED ASSOC, V314, P2241, DOI 10.1001/jama.2015.16174
   Lin S, 2017, DIABETIC MED, V34, P654, DOI 10.1111/dme.13197
   Liu C, 2015, DIABETES TECHNOL THE, V17, P142, DOI 10.1089/dia.2014.0190
   Mathur R, 2015, EXPERT REV GASTROENT, V9, P1087, DOI 10.1586/17474124.2015.1051029
   Mikkelsen KH, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0142352
   Minges KE, 2017, DIABETES RES CLIN PR, V126, P68, DOI 10.1016/j.diabres.2017.01.012
   Minges KE, 2016, DIABETES EDUCATOR, V42, P538, DOI 10.1177/0145721716654006
   Mobini R, 2017, DIABETES OBES METAB, V19, P579, DOI 10.1111/dom.12861
   Munir KM, 2015, EXPERT OPIN PHARMACO, V16, P2331, DOI 10.1517/14656566.2015.1084502
   Murphy EA, 2015, CURR OPIN CLIN NUTR, V18, P515, DOI 10.1097/MCO.0000000000000209
   Nansel TR, 2013, DIABETES RES CLIN PR, V100, P126, DOI 10.1016/j.diabres.2012.12.025
   Nwosu BU, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0137525
   Otero M, 2005, FEBS LETT, V579, P295, DOI 10.1016/j.febslet.2004.11.024
   Otto-Buczkowska E, 2017, INSULIN, V25, P10
   Ozdemir Oner, 2013, J Complement Integr Med, V10, DOI 10.1515/jcim-2012-0054
   Price SA, 2014, OBES RES CLIN PRACT, V8, pE178, DOI 10.1016/j.orcp.2013.03.007
   Pulgaron ER, 2014, CURR DIABETES REP, V14, DOI 10.1007/s11892-014-0508-y
   Reijnders D, 2016, CELL METAB, V24, P63, DOI [10.1016/j.cmet.2016.06.016, 10.1016/j.cmet.2016.07.008]
   Reinehr T, 2013, WORLD J DIABETES, V4, P270, DOI 10.4239/wjd.v4.i6.270
   Rodrigues RR, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.02306
   Samah S, 2016, DIABETES RES CLIN PR, V118, P172, DOI 10.1016/j.diabres.2016.06.014
   Sidhu M, 2017, AUST FAM PHYSICIAN, V46, P206
   Sun J, 2016, BRIT J NUTR, V115, P1167, DOI 10.1017/S0007114516000076
   Uusitalo U, 2016, JAMA PEDIATR, V170, P20, DOI 10.1001/jamapediatrics.2015.2757
   Versini M, 2014, AUTOIMMUN REV, V13, P981, DOI 10.1016/j.autrev.2014.07.001
   Vrieze A, 2014, J HEPATOL, V60, P824, DOI 10.1016/j.jhep.2013.11.034
   Wilding JPH, 2014, INT J CLIN PRACT, V68, P682, DOI 10.1111/ijcp.12384
   Zhang M, 2016, WORLD J GASTROENTERO, V22, P8905, DOI 10.3748/wjg.v22.i40.8905
   Zhang QQ, 2016, MEDICINA-LITHUANIA, V52, P28, DOI 10.1016/j.medici.2015.11.008
NR 57
TC 115
Z9 119
U1 1
U2 38
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1520-7552
EI 1520-7560
J9 DIABETES-METAB RES
JI Diabetes-Metab. Res. Rev.
PD OCT
PY 2018
VL 34
IS 7
AR e3042
DI 10.1002/dmrr.3042
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA GV7PM
UT WOS:000446320800011
PM 29931823
OA Green Published, hybrid
DA 2023-06-08
ER

PT J
AU Shih, CT
   Yeh, YT
   Lin, CC
   Yang, LY
   Chiang, CP
AF Shih, Ching-Tang
   Yeh, Yao-Tsung
   Lin, Ching-Chiang
   Yang, Lin-Yu
   Chiang, Chih-Po
TI Akkermansia muciniphilais Negatively Correlated with Hemoglobin A1c in
   Refractory Diabetes
SO MICROORGANISMS
LA English
DT Article
DE gut microbiota; type 2 diabetes; refractory diabetes; hemoglobin A1C;
   Akkermansia muciniphila
ID STIMULATES GLUCOSE-UPTAKE; GUT MICROBIOTA; COMPLICATIONS; OBESITY;
   IMPACT; ENDOTOXEMIA; METABOLISM; MANAGEMENT; METFORMIN; INSIGHTS
AB Patients with refractory diabetes are defined as type 2 diabetes (T2D) patients; they cannot achieve optimal glycemic control and exhibit persistent elevations of hemoglobin A1c (HbA1c) >= 8% while on appropriate therapy. Hyperglycemia can lead to severe microvascular/macrovascular complications. However, in contrast to T2D, few studies have focused specifically on the gut microbiota in refractory diabetes. To examine this issue, we recruited 79 subjects with T2D and refractory diabetes (RT2D), and all subjects received standard therapy with Metformin or other hypoglycemic agents with or without insulin for at least one year. The alpha-diversity displayed no significant difference, whereas the beta-diversity showed a marginal significance (p= 0.054) between T2D and RT2D. The evaluation of taxonomic indices revealed reductions in bothAkkermansia muciniphilaandFusobacteriumand a corresponding enrichment ofBacteroides vulgatus, Veillonella denticariosiamong those with RT2D. These microbial markers distinguished RT2D from T2D with an acceptable degree of discrimination (area under the curve (AUC) = 0.719,p< 0.01) and were involved in several glucose-related functional pathways. Furthermore, the relative abundance ofAkkermansia muciniphilawas negatively correlated with HbA1c. Our combined results reveal unique features of the gut microbiota in RT2D and suggest that the evaluation of the gut microbiota could provide insights into the mechanisms underlying glycemic control and the impact of therapeutic modalities in patients with RT2D.
C1 [Shih, Ching-Tang] Fooyin Univ Hosp, Dept Family Med, Pingtung 92849, Taiwan.
   [Yeh, Yao-Tsung; Lin, Ching-Chiang] Fooyin Univ Hosp, Dept Educ & Res, Pingtung 92849, Taiwan.
   [Yeh, Yao-Tsung; Lin, Ching-Chiang; Chiang, Chih-Po] Fooyin Univ, Dept Med Lab Sci & Biotechnol, Kaohsiung 83102, Taiwan.
   [Yeh, Yao-Tsung] Fooyin Univ, Aging & Dis Prevent Res Ctr, Kaohsiung 83102, Taiwan.
   [Yang, Lin-Yu] Fooyin Univ Hosp, Dept Community Hlth Ctr, Pingtung 92849, Taiwan.
   [Chiang, Chih-Po] Kaohsiung Med Univ Hosp, Dept Surg, Kaohsiung 80756, Taiwan.
   [Chiang, Chih-Po] Kaohsiung Med Univ Hosp, Dept Surg, Div Breast Surg, Kaohsiung 80756, Taiwan.
C3 Fooyin University; Fooyin University; Kaohsiung Medical University;
   Kaohsiung Medical University Hospital; Kaohsiung Medical University;
   Kaohsiung Medical University Hospital
RP Chiang, CP (通讯作者)，Fooyin Univ, Dept Med Lab Sci & Biotechnol, Kaohsiung 83102, Taiwan.; Chiang, CP (通讯作者)，Kaohsiung Med Univ Hosp, Dept Surg, Kaohsiung 80756, Taiwan.; Chiang, CP (通讯作者)，Kaohsiung Med Univ Hosp, Dept Surg, Div Breast Surg, Kaohsiung 80756, Taiwan.
EM aaronshih@hotmail.com; glycosamine@yahoo.com.tw; x6053@ms25.hinet.net;
   1200570@fy.org.tw; blackcch73@gmail.com
RI Chiang, Chih-Po/AAZ-5092-2020
OI Chiang, Chih-Po/0000-0002-5399-3902
FU Fooyin University Hospital [FH-HR-106-02]; Fooyin University
FX The authors extend special thanks for the funding and resources provided
   by the Fooyin University Hospital (FH-HR-106-02) and Fooyin University.
CR Al-Otaibi Fawzia Eida, 2014, J Med Case Rep, V8, P365, DOI 10.1186/1752-1947-8-365
   Aron-Wisnewsky J, 2012, NAT REV GASTRO HEPAT, V9, P590, DOI 10.1038/nrgastro.2012.161
   Aronson R, 2018, DIABETES RES CLIN PR, V137, P128, DOI 10.1016/j.diabres.2017.10.028
   Aronson R, 2016, J DIABETES, V8, P76, DOI 10.1111/1753-0407.12257
   Blandino G, 2016, DIABETES METAB, V42, P303, DOI 10.1016/j.diabet.2016.04.004
   Burcelin R, 2011, ACTA DIABETOL, V48, P257, DOI 10.1007/s00592-011-0333-6
   Byun R, 2007, INT J SYST EVOL MICR, V57, P2844, DOI 10.1099/ijs.0.65096-0
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   Cani PD, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.01765
   Cani PD, 2009, CURR PHARM DESIGN, V15, P1546, DOI 10.2174/138161209788168164
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Delzenne NM, 2015, DIABETOLOGIA, V58, P2206, DOI 10.1007/s00125-015-3712-7
   Fowler M.J., 2008, CLIN DIABETES, V26, P77, DOI [DOI 10.2337/DIACLIN.26.2.77, 10.2337/diaclin.26.2.77]
   Galgani JE, 2007, ANN NUTR METAB, V51, P482, DOI 10.1159/000111171
   Greer RL, 2016, NAT COMMUN, V7, DOI 10.1038/ncomms13329
   He ZH, 2004, ENDOCRIN METAB CLIN, V33, P215, DOI 10.1016/j.ecl.2003.12.003
   Kalra S, 2015, US ENDOCRINOL, V11, P32, DOI DOI 10.17925/USE.2015.11.1.32
   Kalra S, 2017, J PAK MED ASSOC, V67, P146
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Keijser BJF, 2008, J DENT RES, V87, P1016, DOI 10.1177/154405910808701104
   Kesika P, 2019, BIOMED RES INT, V2019, DOI 10.1155/2019/1531567
   Kori J., 2020, CHARACTERIZATION ORA, DOI [10.1101/2020.04.09.20052613, DOI 10.1101/2020.04.09.20052613]
   Kostic AD, 2012, GENOME RES, V22, P292, DOI 10.1101/gr.126573.111
   Kuang YS, 2017, GIGASCIENCE, V6, DOI 10.1093/gigascience/gix058
   Kuno T, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-19545-1
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Li Q, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-62224-3
   Li X., 2019, RES SQ, DOI [10.21203/rs.2.17469/v2, DOI 10.21203/RS.2.17469/V2]
   Madigan C, 2000, DIABETES CARE, V23, P1472, DOI 10.2337/diacare.23.10.1472
   Mancl KA, 2013, WOUND REPAIR REGEN, V21, P352, DOI 10.1111/wrr.12034
   Mathers CD, 2006, PLOS MED, V3, DOI 10.1371/journal.pmed.0030442
   Munoz-Garach A, 2016, ENDOCRINOL NUTR, V63, P560, DOI 10.1016/j.endonu.2016.07.008
   Ndisang JF, 2017, J DIABETES RES, V2017, DOI 10.1155/2017/1478294
   Nugent C, 2001, J BIOL CHEM, V276, P9149, DOI 10.1074/jbc.M009817200
   Pascale A, 2019, CURR OPIN PHARMACOL, V49, P1, DOI 10.1016/j.coph.2019.03.011
   Pedersen HK, 2016, NATURE, V535, P376, DOI 10.1038/nature18646
   Plovier H, 2017, NAT MED, V23, P107, DOI 10.1038/nm.4236
   Pussinen PJ, 2011, DIABETES CARE, V34, P392, DOI 10.2337/dc10-1676
   Rena G, 2017, DIABETOLOGIA, V60, P1577, DOI 10.1007/s00125-017-4342-z
   Riserus U, 2009, PROG LIPID RES, V48, P44, DOI 10.1016/j.plipres.2008.10.002
   Rubino F, 2014, DIABETES CARE, V37, pE254, DOI 10.2337/dc14-1481
   Salah M, 2019, OMICS, V23, P477, DOI 10.1089/omi.2019.0063
   Sanna S, 2019, NAT GENET, V51, P600, DOI 10.1038/s41588-019-0350-x
   SHAMOON H, 1993, NEW ENGL J MED, V329, P977, DOI 10.1056/nejm199309303291401
   Shen YJ, 2017, ENDOCRINE, V55, P75, DOI 10.1007/s12020-016-1014-6
   Solomon SD, 2017, DIABETES CARE, V40, P412, DOI 10.2337/dc16-2641
   TAO YW, 2020, J TRANSL MED, V0018
   Turner RC, 1998, LANCET, V352, P837, DOI 10.1016/s0140-6736(98)07019-6
   Utzschneider KM, 2016, J CLIN ENDOCR METAB, V101, P2622, DOI 10.1210/jc.2015-4251
   Vrieze A, 2014, J HEPATOL, V60, P824, DOI 10.1016/j.jhep.2013.11.034
   Xu Y, 2020, FRONT MICROBIOL, V11, DOI 10.3389/fmicb.2020.00219
   Yassour M, 2016, GENOME MED, V8, DOI 10.1186/s13073-016-0271-6
   YU NC, 1993, P NATL ACAD SCI USA, V90, P4042, DOI 10.1073/pnas.90.9.4042
   Yuan BC, 2020, MICROORGANISMS, V8, DOI 10.3390/microorganisms8060959
   Zhang L, 2018, PATHOG DIS, V76, DOI 10.1093/femspd/fty028
   Zhang S, 2018, J CANCER, V9, P1652, DOI 10.7150/jca.24048
   Zhang T, 2019, MICROB BIOTECHNOL, V12, P1109, DOI 10.1111/1751-7915.13410
   Zhang XY, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0071108
   Zhong HZ, 2019, EBIOMEDICINE, V47, P373, DOI 10.1016/j.ebiom.2019.08.048
NR 59
TC 17
Z9 17
U1 2
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-2607
J9 MICROORGANISMS
JI Microorganisms
PD SEP
PY 2020
VL 8
IS 9
AR 1360
DI 10.3390/microorganisms8091360
PG 13
WC Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology
GA OE7HE
UT WOS:000580696500001
PM 32899513
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Caggiano, G
   Cosola, C
   Di Leo, V
   Gesualdo, M
   Gesualdo, L
AF Caggiano, Gianvito
   Cosola, Carmela
   Di Leo, Vincenzo
   Gesualdo, Marcantonio
   Gesualdo, Loreto
TI Microbiome modulation to correct uremic toxins and to preserve kidney
   functions
SO CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
LA English
DT Review
DE chronic kidney disease; drugs; fecal microbiome transplantation;
   functional nutrition; gut microbiome; gut-kidney axis; prebiotics;
   probiotics; smart bacteria; uremic toxins
ID GUT MICROBIOTA; FECAL MICROBIOTA; AKKERMANSIA-MUCINIPHILA; DISEASE;
   ALTERS; DIET; TRANSPLANTATION; INFLAMMATION; PROGRESSION; METFORMIN
AB Purpose of review
   The association between dysbiosis and CKD is well established. This review focuses on the current understanding of microbiome, in normal individuals and CKD patients, in order to hypothesize how to correct uremic toxins levels and preserve the renal function and reduce associated comorbidities. Here we discuss our current opinion on microbiome modulation in order to manage the CKD-associated dysbiosis.
   Recent findings
   Emerging evidence confirms the role of gut microbiome in the progression of CKD. In this scenario, the need is felt to set up multifaceted approaches for dysbiosis management. Among many strategies able to improve gut wellness, a crucial approach is represented by the functional nutrition. At the same time, drugbased treatments show significant results in microbiome modulation. Furthermore, we examine here the potentialities of fecal microbiome transplantation (FMT) in CKD, an approach currently applied in Clostridium difficile infection.
   Summary
   The gut microbiome plays a pivotal role in the pathophysiology of CKD. The vicious cycle triggered by kidney function decline leads to gut dysbiosis. Considering the gut microbiome as a therapeutic target in CKD, multiple approaches aimed at its modulation should be envisioned to preserve kidney function. Dietary interventions and pharmacological strategies are able to improve microbiome dysbiosis, oxidative stress and fibrosis. Additionally, FMT could represent a promising novel therapy in the management of CKD-associated dysbiosis.
C1 [Caggiano, Gianvito; Cosola, Carmela; Di Leo, Vincenzo; Gesualdo, Loreto] Univ Bari Aldo Moro, Dept Emergency & Organ Transplantat, Nephrol Dialysis & Transplantat Unit, Bari, Italy.
   [Gesualdo, Marcantonio] Univ Turin, AOU Citta Salute & Sci, Dept Med Sci, Div Gastroenterol, Turin, Italy.
C3 Universita degli Studi di Bari Aldo Moro; A.O.U. Citta della Salute e
   della Scienza di Torino; University of Turin
RP Gesualdo, L (通讯作者)，Univ Bari Aldo Moro, Dept Emergency & Organ Transplantat, Nephrol Dialysis & Transplantat Unit, Bari, Italy.
EM loreto.gesualdo@uniba.it
RI Gesualdo, Marcantonio/ABD-1207-2020; Di Leo, Vincenzo/AAP-1691-2021;
   Gesualdo, Marcantonio/AAD-8143-2021
OI Di Leo, Vincenzo/0000-0001-6130-1999; Gesualdo,
   Marcantonio/0000-0003-4446-1768; Caggiano, Gianvito/0000-0001-6203-0414
CR Allegretti JR, 2019, LANCET, V394, P420, DOI 10.1016/S0140-6736(19)31266-8
   [Anonymous], THIS IS 1 STUDIES EL
   Arora T, 2016, J INTERN MED, V280, P339, DOI 10.1111/joim.12508
   Black AP, 2018, J RENAL NUTR, V28, P208, DOI 10.1053/j.jrn.2017.11.007
   Blum HE, 2017, ADV MED SCI-POLAND, V62, P414, DOI 10.1016/j.advms.2017.04.005
   Briskey D, 2017, CLIN EXP NEPHROL, V21, P7, DOI 10.1007/s10157-016-1255-y
   Cammarota G, 2017, GUT, V66, P569, DOI 10.1136/gutjnl-2016-313017
   Carmines PK, 2010, CURR OPIN NEPHROL HY, V19, P85, DOI 10.1097/MNH.0b013e32833240fc
   Chen YY, 2019, J TRANSL MED, V17, DOI 10.1186/s12967-018-1756-4
   Collins AJ, 2015, KIDNEY INT SUPPL, V5, P2, DOI 10.1038/kisup.2015.2
   Cosola C, 2019, J NEPHROL, V32, P27, DOI 10.1007/s40620-018-0516-0
   Cosola C, 2018, NUTRIENTS, V10, DOI 10.3390/nu10070808
   Cosola C, 2018, PHARMACOL RES, V130, P132, DOI 10.1016/j.phrs.2018.03.003
   Cosola C, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0169635
   Cupisti A, 2018, J NEPHROL, V31, P457, DOI 10.1007/s40620-018-0497-z
   Cupisti A, 2017, NUTRIENTS, V9, DOI 10.3390/nu9050444
   De Angelis M, 2015, APPL ENVIRON MICROB, V81, P7945, DOI 10.1128/AEM.02507-15
   De Angelis M, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0099006
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Devlin AS, 2016, CELL HOST MICROBE, V20, P709, DOI 10.1016/j.chom.2016.10.021
   Di Iorio BR, 2018, NEPHROL DIAL TRANSPL, V33, P804, DOI 10.1093/ndt/gfx203
   Di Iorio BR, 2019, J CLIN MED, V8, DOI 10.3390/jcm8091424
   Ding RX, 2019, J FOOD DRUG ANAL, V27, P623, DOI 10.1016/j.jfda.2018.12.012
   Everard A, 2013, BEST PRACT RES CL GA, V27, P73, DOI 10.1016/j.bpg.2013.03.007
   Felizardo RJF, 2016, CLIN TRANSL IMMUNOL, V5, DOI 10.1038/cti.2016.36
   Fiaccadori E, 2019, AM J KIDNEY DIS
   Gong J, 2019, SEMIN NEPHROL, V39, P107, DOI 10.1016/j.semnephrol.2018.10.009
   Gopalakrishnan V, 2018, SCIENCE, V359, P97, DOI 10.1126/science.aan4236
   Gryp T, 2017, TOXINS, V9, DOI 10.3390/toxins9020052
   Ichii O, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0108448
   Jackson MA, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-018-05184-7
   Jia LP, 2018, KIDNEY BLOOD PRESS R, V43, P1623, DOI 10.1159/000494677
   Jiang SH, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-02989-2
   Kanbay M, 2018, INT UROL NEPHROL, V50, P1453, DOI 10.1007/s11255-018-1873-2
   Kang DW, 2017, MICROBIOME, V5, DOI 10.1186/s40168-016-0225-7
   Koeth RA, 2013, NAT MED, V19, P576, DOI 10.1038/nm.3145
   Koppe L, 2018, TOXINS, V10, DOI 10.3390/toxins10040155
   Koppe L, 2015, KIDNEY INT, V88, P958, DOI 10.1038/ki.2015.255
   Ku E, 2019, AM J KIDNEY DIS, V74, P120, DOI 10.1053/j.ajkd.2018.12.044
   Lau WL, 2018, J PHARMACOL EXP THER, V367, P452, DOI 10.1124/jpet.118.251389
   Lau WL, 2018, CLIN SCI, V132, P509, DOI 10.1042/CS20171107
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Lee J, 2013, ARCH PHARM RES, V36, P208, DOI 10.1007/s12272-013-0023-8
   Li J, 2016, CIRCULATION, V133, P2434, DOI 10.1161/CIRCULATIONAHA.115.019645
   Li LZ, 2017, DRUG DES DEV THER, V11, P3531, DOI 10.2147/DDDT.S150825
   Lin CJ, 2012, ARCH MED RES, V43, P451, DOI 10.1016/j.arcmed.2012.08.002
   Mahmoodpoor F, 2017, BIOMED PHARMACOTHER, V93, P412, DOI 10.1016/j.biopha.2017.06.066
   Marzocco S, 2013, BLOOD PURIFICAT, V35, P196, DOI 10.1159/000346628
   Meijers B, 2018, PHARMACOL RES, V133, P101, DOI 10.1016/j.phrs.2018.04.023
   Meijers B, 2019, NAT REV NEPHROL, V15, P531, DOI 10.1038/s41581-019-0172-1
   Meijers B, 2018, TOXINS, V10, DOI 10.3390/toxins10070298
   Mihai S, 2018, J IMMUNOL RES, V2018, DOI 10.1155/2018/2180373
   Mishima E, 2018, AM J PHYSIOL-RENAL, V315, pF824, DOI 10.1152/ajprenal.00314.2017
   Mishima E, 2015, J AM SOC NEPHROL, V26, P1787, DOI 10.1681/ASN.2014060530
   Montemurno E, 2014, KIDNEY BLOOD PRESS R, V39, P114, DOI 10.1159/000355785
   Nallu A, 2017, TRANSL RES, V179, P24, DOI 10.1016/j.trsl.2016.04.007
   Pavan M, 2016, MINERVA UROL NEFROL, V68, P222
   Pevsner-Fischer M, 2017, CURR OPIN NEPHROL HY, V26, P1, DOI 10.1097/MNH.0000000000000293
   Piccolo M, 2015, MICROB ECOL, V70, P557, DOI 10.1007/s00248-015-0592-9
   Rossi M, 2015, NUTR METAB CARDIOVAS, V25, P860, DOI 10.1016/j.numecd.2015.03.015
   Saadat YR, 2019, PHARMACOL RES, V139, P191, DOI 10.1016/j.phrs.2018.11.023
   Sampaio-Maia B, 2016, ADV APPL MICROBIOL, V96, P65, DOI 10.1016/bs.aambs.2016.06.002
   Santisteban MM, 2017, CIRC RES, V120, P312, DOI 10.1161/CIRCRESAHA.116.309006
   Shah NB, 2019, CLIN J AM SOC NEPHRO, V14, P692, DOI 10.2215/CJN.12161018
   Tang WHW, 2017, CIRC RES, V120, P1183, DOI 10.1161/CIRCRESAHA.117.309715
   Ticinesi A, 2018, GUT, V67, P2097, DOI 10.1136/gutjnl-2017-315734
   Vallianou NG, 2018, DIABETES RES CLIN PR, V146, P111, DOI 10.1016/j.diabres.2018.10.008
   Vaziri ND, 2013, KIDNEY INT, V83, P308, DOI 10.1038/ki.2012.345
   Vaziri ND, 2012, CURR OPIN NEPHROL HY, V21, P587, DOI 10.1097/MNH.0b013e328358c8d5
   Wu IW, 2011, NEPHROL DIAL TRANSPL, V26, P938, DOI 10.1093/ndt/gfq580
   Yacoub R, 2017, KIDNEY INT, V91, P521, DOI 10.1016/j.kint.2017.01.003
   Yan XF, 2016, J DIABETES RES, V2016, DOI 10.1155/2016/2093171
   Yang T, 2019, J AM HEART ASSOC, V8, DOI 10.1161/JAHA.118.010721
   Yoshifuji A, 2016, NEPHROL DIAL TRANSPL, V31, P401, DOI 10.1093/ndt/gfv353
   Zhang XY, 2017, DIABETES THER, V8, P293, DOI 10.1007/s13300-017-0226-y
   Zhang X, 2015, SCI REP-UK, V5, DOI 10.1038/srep14405
   Zipursky JS, 2012, CLIN INFECT DIS, V55, P1652, DOI 10.1093/cid/cis809
NR 77
TC 19
Z9 19
U1 1
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1062-4821
EI 1473-6543
J9 CURR OPIN NEPHROL HY
JI Curr. Opin. Nephrol. Hypertens.
PD JAN
PY 2020
VL 29
IS 1
BP 49
EP 56
DI 10.1097/MNH.0000000000000565
PG 8
WC Urology & Nephrology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology; Cardiovascular System & Cardiology
GA QI8ZF
UT WOS:000619275000007
PM 31725010
DA 2023-06-08
ER

PT J
AU Van Meulebroek, L
   Cameron, S
   Plekhova, V
   De Spiegeleer, M
   Wijnant, K
   Michels, N
   De Henauw, D
   Lapauw, B
   Takats, Z
   Vanhaecke, L
AF Van Meulebroek, Lieven
   Cameron, Simon
   Plekhova, Vera
   De Spiegeleer, Margot
   Wijnant, Kathleen
   Michels, Nathalie
   De Henauw, Stefaan
   Lapauw, Bruno
   Takats, Zoltan
   Vanhaecke, Lynn
TI Rapid LA-REIMS and comprehensive UHPLC-HRMS for metabolic phenotyping of
   feces
SO TALANTA
LA English
DT Article
DE Laser-assisted rapid evaporative ionization mass spectrometry;
   Ultra-high performance liquid chromatography; high-resolution mass
   spectrometry; Fecal metabolomics; Type 2 diabetes mellitus
ID IONIZATION MASS-SPECTROMETRY; METHYLGLYOXAL LEVELS; SAMPLE PREPARATION;
   HUMAN URINE; IN-VIVO; METFORMIN; PLASMA; IDENTIFICATION; CHOLESTEROL;
   CHALLENGES
AB Ambient ionization-based techniques hold great potential for rapid point-of-care applicable metabolic fingerprinting of tissue and fluids. Hereby, feces represents a unique biospecimen as it integrates the complex interactions between the diet, gut microbiome and host, and is therefore ideally suited to study the involvement of the diet-gut microbiome axis in metabolic diseases and their treatments at a molecular level. We present a new method for rapid ( < 10 s) metabolic fingerprinting of feces, i.e. laser-assisted rapid evaporative ionization mass spectrometry (LA-REIMS) with an Nd:YAG laser (2940 nm) and quadrupole Time-of-Flight mass spectrometer as main components. The LA-REIMS method was implemented on mimicked crude feces samples from individuals that were assigned a state of type 2 diabetes or euglycaemia. Based on the generated fingerprints, enclosing 4923 feature ions, significant segregation according to disease classification was achieved through orthogonal partial least squares discriminant analysis (Q(2) (Y) of 0.734 and p-value of 1.93e(-17)) and endorsed by a general classification accuracy of 90.5%. A comparison between the discriminative performance of the novel LA-REIMS and our established ultra-high performance liquid-chromatography high-resolution MS (UHPLC-HRMS) metabolomics and lipidomics methodologies for fingerprinting of stool was performed. Based on the supervised modelling results upon UHPLC-HRMS (Q(2) (Y) >= 0.655 and p-value <= 4.11 e(-5)), equivalent or better discriminative performance of LA-REIMS fingerprinting was concluded. Eventually, comprehensive UHPLC-HRMS was employed to assess metabolic alterations as observed for the defined classes, whereby metformin treatment of the type 2 diabetes patients was considered a relevant study factor to acquire new mechanistic insights. More specifically, ten metabolization products of metformin were identified, with (hydroxylated) triazepinone and metformin-cholesterol reported for the first time in vivo.In conclusion, LA-REIMS was established as an expedient strategy for rapid metabolic fingerprinting of feces, whereby potential implementations may relate, but are not limited to differential diagnosis and treatment efficacy evaluation of metabolic diseases. Yet, LC-HRMS remains essential for in-depth biological interpretation.
C1 [Van Meulebroek, Lieven; Plekhova, Vera; De Spiegeleer, Margot; Wijnant, Kathleen; Vanhaecke, Lynn] Univ Ghent, Fac Vet Med, Dept Vet Publ Hlth & Food Safety, Lab Chem Anal, Salisburylaan 133, B-9820 Merelbeke, Belgium.
   [Cameron, Simon; Takats, Zoltan] Imperial Coll London, Fac Med, Dept Metab Digest & Reprod, Div Syst Med, St Dunstans Rd, London SW7 2AZ, England.
   [Cameron, Simon; Vanhaecke, Lynn] Queens Univ Belfast, Sch Biol Sci, Lisburn Rd 97, Belfast, Antrim, North Ireland.
   [Wijnant, Kathleen; Michels, Nathalie; De Henauw, Stefaan] Univ Ghent, Fac Med & Hlth Sci, Dept Publ Hlth & Primary Care, Corneel Heymanslaan 10, B-9000 Ghent, Belgium.
   [Lapauw, Bruno] Ghent Univ Hosp, Dept Endocrinol, Corneel Heymanslaan 10, B-9000 Ghent, Belgium.
C3 Ghent University; Imperial College London; Queens University Belfast;
   Ghent University; Ghent University Hospital; Ghent University; Ghent
   University Hospital
RP Vanhaecke, L (通讯作者)，Univ Ghent, Fac Vet Med, Dept Vet Publ Hlth & Food Safety, Lab Chem Anal, Salisburylaan 133, B-9820 Merelbeke, Belgium.
EM Lieven.VanMeulenbroek@ugent.be; S.Cameron@imperial.ac.uk;
   Vera.Plekhova@ugent.be; Margot.DeSpiegeleer@ugent.be;
   Kathleen.Wijnant@ugent.be; Nathalie.Michels@ugent.be;
   Stefaan.DeHenauw@ugent.be; Bruno.Lapauw@uzgent.be;
   z.takats@imperial.ac.uk; Lynn.Vanhaecke@Ugent.be
RI Michels, Nathalie/C-2819-2012; Wijnant, Kathleen/AAW-1114-2020; Lapauw,
   Bruno/AAB-4463-2021; De Spiegeleer, Margot/ABE-4118-2020; Vanhaecke,
   Lynn/N-1061-2017
OI Michels, Nathalie/0000-0002-3069-7254; Wijnant,
   Kathleen/0000-0002-8242-4522; Vanhaecke, Lynn/0000-0003-0400-2188;
   Cameron, Simon/0000-0001-9570-135X; Lapauw, Bruno/0000-0002-1584-4965
FU VLAIO [IM 150740 - A16/OC/0006]; UGent BOF GOA [2017/000102]; FWO
   Hercules [AUGE/17/09]; FWO ERC Runner-up [G0G0119N]
FX This work was supported by VLAIO (grant number IM 150740 - A16/OC/0006),
   UGent BOF GOA (grant number 2017/000102), FWO Hercules (grant number
   AUGE/17/09), and FWO ERC Runner-up (grant number G0G0119N). The funding
   source had no involvement in the study design, writing of the report, or
   decision to submit the article for publication.
CR Alfaro CM, 2016, ANAL BIOANAL CHEM, V408, P5407, DOI 10.1007/s00216-016-9627-4
   Balog J, 2015, ANGEW CHEM INT EDIT, V54, P11059, DOI 10.1002/anie.201502770
   Beisswenger PJ, 1999, DIABETES, V48, P198, DOI 10.2337/diabetes.48.1.198
   Bussche JV, 2015, ANAL CHEM, V87, P10927, DOI 10.1021/acs.analchem.5b02688
   Calligaris D, 2014, P NATL ACAD SCI USA, V111, P15184, DOI 10.1073/pnas.1408129111
   Cohen-Or I, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0017974
   De Paepe E, 2018, ANAL CHIM ACTA, V1033, P108, DOI 10.1016/j.aca.2018.06.065
   Di Guida R, 2016, METABOLOMICS, V12, DOI 10.1007/s11306-016-1030-9
   Dieterle F, 2006, ANAL CHEM, V78, P4281, DOI 10.1021/ac051632c
   Eberlin LS, 2012, CANCER RES, V72, P645, DOI 10.1158/0008-5472.CAN-11-2465
   Eriksson L, 2008, J CHEMOMETR, V22, P594, DOI 10.1002/cem.1187
   Fatou B, 2016, SCI REP-UK, V6, DOI 10.1038/srep25919
   Ferreira CR, 2016, CLIN CHEM, V62, P99, DOI 10.1373/clinchem.2014.237164
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Godzien J, 2013, ELECTROPHORESIS, V34, P2812, DOI 10.1002/elps.201300053
   Gratton J, 2016, ANAL CHEM, V88, P4661, DOI 10.1021/acs.analchem.5b04159
   Kamleh MA, 2012, ANAL CHEM, V84, P2670, DOI 10.1021/ac202733q
   KNECHT KJ, 1992, ARCH BIOCHEM BIOPHYS, V294, P130, DOI 10.1016/0003-9861(92)90146-N
   Kole PL, 2011, BIOMED CHROMATOGR, V25, P199, DOI 10.1002/bmc.1560
   Kuo TH, 2020, ANAL CHEM, V92, P2353, DOI 10.1021/acs.analchem.9b05454
   Li Li-Hua, 2017, Mass Spectrom (Tokyo), V6, pS0060, DOI 10.5702/massspectrometry.S0060
   Martin FPJ, 2010, J PROTEOME RES, V9, P5284, DOI 10.1021/pr100554m
   Matysik S, 2016, TRENDS FOOD SCI TECH, V57, P244, DOI 10.1016/j.tifs.2016.05.011
   MCLELLAN AC, 1992, ANAL BIOCHEM, V206, P17, DOI 10.1016/S0003-2697(05)80005-3
   National Institutes of Health, 2010, POINT OF CAR DIAGN T
   Nayak L, 2016, ANN TRANSL MED, V4, DOI 10.21037/atm.2016.10.40
   Olah M, 2004, J COMPUT AID MOL DES, V18, P437, DOI 10.1007/s10822-004-4060-8
   Ruggiero-Lopez D, 2000, DIABETES, V49, pA124
   Schafer KC, 2009, ANGEW CHEM INT EDIT, V48, P8240, DOI 10.1002/anie.200902546
   Sumner LW, 2007, METABOLOMICS, V3, P211, DOI 10.1007/s11306-007-0082-2
   Van Meulebroek L, 2017, ANAL CHEM, V89, P12502, DOI 10.1021/acs.analchem.7b03606
   Verougstraete N, 2017, CLIN CHEM LAB MED, V55, P462, DOI 10.1515/cclm-2016-0411
   Vuckovic D, 2012, ANAL BIOANAL CHEM, V403, P1523, DOI 10.1007/s00216-012-6039-y
   Whang A, 2019, EBIOMEDICINE, V39, P591, DOI 10.1016/j.ebiom.2018.11.046
   Wiklund S, 2008, ANAL CHEM, V80, P115, DOI 10.1021/ac0713510
   Wulffele MG, 2004, J INTERN MED, V256, P1, DOI 10.1111/j.1365-2796.2004.01328.x
   Xu T, 2015, DIABETES CARE, V38, P1858, DOI 10.2337/dc15-0658
NR 37
TC 9
Z9 9
U1 2
U2 29
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0039-9140
EI 1873-3573
J9 TALANTA
JI Talanta
PD SEP
PY 2020
VL 217
AR 121043
DI 10.1016/j.talanta.2020.121043
PG 9
WC Chemistry, Analytical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA LU6RK
UT WOS:000537880200045
PM 32498888
OA Green Published, Green Accepted
DA 2023-06-08
ER

PT J
AU Li, ZT
   Ke, HR
   Wang, Y
   Chen, SZ
   Liu, XY
   Lin, QY
   Wang, P
   Chen, Y
AF Li, Zitong
   Ke, Haoran
   Wang, Ying
   Chen, Shuze
   Liu, Xiuying
   Lin, Qianyun
   Wang, Pu
   Chen, Ye
TI Global trends in Akkermansia muciniphila research: A bibliometric
   visualization
SO FRONTIERS IN MICROBIOLOGY
LA English
DT Article
DE Akkermansia muciniphila; gut microbiota; bibliometrics; trends;
   visualization
ID GUT MICROBIOTA; DIETARY FIBER; ABUNDANCE
AB BackgroundAkkermansia muciniphila is a member of the gut microbiome, using mucin as sources of carbon, nitrogen, and energy. Since the first discovery of this unique bacterium in 2004, A. muciniphila has been extensively studied. It is considered a promising "next-generation beneficial microbe." The purpose of this paper is to sort out the research status and summarize the hotspots through bibliometric analysis of the publications of A. muciniphila. MethodsThe publications about A. muciniphila from January 2004 to February 2022 were obtained from the Web of Science Core Collection. Visualization analyses were performed using three bibliometric tools and GraphPad Prism. ResultsA total of 1,478 published documents were analyzed. Annual publication number grew from 1 in 2004 to 336 in 2021, with China being the leading producer (33.36%). De Vos, Willem M was the most productive author with the highest H-index (documents = 56, H-index = 37), followed by Cani, Patrice D (documents = 35, H-index = 25). And Scientific Reports published the most papers. PNAS was the keystone taxa in this field, with high betweenness centrality (0.11) and high frequency. The keywords with high frequency in recent years include: oxidative stress, diet, metformin, fecal microbiota transplantation, short-chain fatty acids, polyphenols, microbiota metabolites and so on. The keyword "oxidative stress" was observed to be increasing in frequency recently. ConclusionOver time, the scope of the research on the clinical uses of A. muciniphila has gradually increased, and was gradually deepened and developed toward a more precise level. A. muciniphila is likely to remain a research hotspot in the foreseeable future and may contribute to human health.
C1 [Li, Zitong; Wang, Ying; Chen, Shuze; Liu, Xiuying; Wang, Pu; Chen, Ye] Southern Med Univ, Nanfang Hosp, Dept Gastroenterol, Guangdong Prov Key Lab Gastroenterol, Guangzhou, Peoples R China.
   [Ke, Haoran] Southern Med Univ, Nanfang Hosp, Dept Infect Dis, Hepatol Unit, Guangzhou, Peoples R China.
   [Lin, Qianyun] Capital Med Univ, Beijing Friendship Hosp, Dept Gastroenterol, Beijing, Peoples R China.
   [Chen, Ye] Southern Med Univ, Shenzhen Hosp, Integrat Microecol Ctr, Dept Gastroenterol, Shenzhen, Peoples R China.
C3 Southern Medical University - China; Southern Medical University -
   China; Capital Medical University; Southern Medical University - China
RP Wang, P; Chen, Y (通讯作者)，Southern Med Univ, Nanfang Hosp, Dept Gastroenterol, Guangdong Prov Key Lab Gastroenterol, Guangzhou, Peoples R China.; Lin, QY (通讯作者)，Capital Med Univ, Beijing Friendship Hosp, Dept Gastroenterol, Beijing, Peoples R China.; Chen, Y (通讯作者)，Southern Med Univ, Shenzhen Hosp, Integrat Microecol Ctr, Dept Gastroenterol, Shenzhen, Peoples R China.
EM linqianyun@foxmail.com; 564035448@qq.com; yechen@smu.edu.cn
FU Special Scientific Research Fund for National Natural Science
   Foundation; National High Technology Research and Development Program of
   China;  [82070543];  [8177031240];  [2021YFA0717001]
FX Funding This work was supported by the Special Scientific Research Fund
   for National Natural Science Foundation, grant numbers 82070543 and
   8177031240, and the National High Technology Research and Development
   Program of China, grant number 2021YFA0717001.
CR Anhe FF, 2015, GUT, V64, P872, DOI 10.1136/gutjnl-2014-307142
   Bae M, 2022, NATURE, V608, P168, DOI 10.1038/s41586-022-04985-7
   Barcena C, 2019, NAT MED, V25, P1234, DOI 10.1038/s41591-019-0504-5
   Belzer C, 2012, ISME J, V6, P1449, DOI 10.1038/ismej.2012.6
   Blacher E, 2019, NATURE, V572, P474, DOI 10.1038/s41586-019-1443-5
   Callahan BJ, 2016, NAT METHODS, V13, P581, DOI [10.1038/NMETH.3869, 10.1038/nmeth.3869]
   Cani PD, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.01765
   Chelakkot C, 2018, EXP MOL MED, V50, DOI 10.1038/emm.2017.282
   Chen CM, 2014, EXPERT OPIN BIOL TH, V14, P1295, DOI 10.1517/14712598.2014.920813
   Chen CM, 2004, P NATL ACAD SCI USA, V101, P5303, DOI 10.1073/pnas.0307513100
   Chen JM, 2022, PHARMACOL RES, V178, DOI 10.1016/j.phrs.2022.106191
   Cheng D, 2021, J APPL MICROBIOL, V130, P1813, DOI 10.1111/jam.14911
   Cheng KM, 2022, FRONT PHARMACOL, V13, DOI 10.3389/fphar.2022.927219
   Cheng KM, 2022, FRONT PUBLIC HEALTH, V10, DOI 10.3389/fpubh.2022.918483
   Cheng KM, 2023, J MED VIROL, V95, DOI 10.1002/jmv.27892
   Dao MC, 2016, GUT, V65, P426, DOI 10.1136/gutjnl-2014-308778
   Deng ZZ, 2021, INT J BIOL MACROMOL, V193, P789, DOI 10.1016/j.ijbiomac.2021.10.188
   Depommier C, 2019, NAT MED, V25, P1096, DOI 10.1038/s41591-019-0495-2
   Derrien M, 2004, INT J SYST EVOL MICR, V54, P1469, DOI 10.1099/ijs.0.02873-0
   Derrien M, 2008, APPL ENVIRON MICROB, V74, P1646, DOI 10.1128/AEM.01226-07
   Derrien M, 2017, MICROB PATHOGENESIS, V106, P171, DOI 10.1016/j.micpath.2016.02.005
   Desai MS, 2016, CELL, V167, P1339, DOI 10.1016/j.cell.2016.10.043
   Diaz-Del Cerro E, 2022, BIOGERONTOLOGY, V23, P35, DOI 10.1007/s10522-021-09943-w
   Dingemanse C, 2015, CARCINOGENESIS, V36, P1388, DOI 10.1093/carcin/bgv120
   Engqvist L, 2008, TRENDS ECOL EVOL, V23, P250, DOI 10.1016/j.tree.2008.01.009
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Everard A, 2011, DIABETES, V60, P2775, DOI 10.2337/db11-0227
   Gopalakrishnan V, 2018, SCIENCE, V359, P97, DOI 10.1126/science.aan4236
   Grander C, 2018, GUT, V67, P892, DOI 10.1136/gutjnl-2016-313432
   Ke HR, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.726707
   Koh A, 2016, CELL, V165, P1332, DOI 10.1016/j.cell.2016.05.041
   Kokol P, 2018, J MED LIBR ASSOC, V106, P81, DOI 10.5195/jmla.2018.181
   Li J, 2017, MICROBIOME, V5, DOI 10.1186/s40168-016-0222-x
   Li ZT, 2022, J INFECT PUBLIC HEAL, V15, P806, DOI 10.1016/j.jiph.2022.06.011
   Lopez-Siles M, 2018, FRONT CELL INFECT MI, V8, DOI 10.3389/fcimb.2018.00281
   Matson V, 2018, SCIENCE, V359, P104, DOI 10.1126/science.aao3290
   Mesnage R, 2021, ENVIRON HEALTH PERSP, V129, DOI 10.1289/EHP6990
   Mitsou EK, 2019, BENEF MICROBES, V10, P741, DOI 10.3920/BM2019.0033
   Olson CA, 2018, CELL, V173, P1728, DOI [10.1016/j.cell.2018.06.051, 10.1016/j.cell.2018.04.027]
   Papadia S, 2008, NAT NEUROSCI, V11, P476, DOI 10.1038/nn2071
   Plovier H, 2017, NAT MED, V23, P107, DOI 10.1038/nm.4236
   Qian KY, 2022, FOOD FUNCT, V13, P2216, DOI [10.1039/d1fo04094d, 10.1039/D1FO04094D]
   Ring C, 2019, GUT MICROBES, V10, P188, DOI 10.1080/19490976.2018.1511663
   Rodrigues VF, 2022, FRONT IMMUNOL, V13, DOI 10.3389/fimmu.2022.934695
   Roshanravan N, 2017, J CARDIOVASC THORAC, V9, P183, DOI 10.15171/jcvtr.2017.32
   Routy B, 2018, SCIENCE, V359, P91, DOI 10.1126/science.aan3706
   Sanapareddy N, 2012, ISME J, V6, P1858, DOI 10.1038/ismej.2012.43
   Schneeberger M, 2015, SCI REP-UK, V5, DOI 10.1038/srep16643
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   van Eck NJ, 2010, SCIENTOMETRICS, V84, P523, DOI 10.1007/s11192-009-0146-3
   Wang F, 2022, J CANCER, V13, P124, DOI 10.7150/jca.63578
   Wang LJ, 2020, GUT, V69, P1988, DOI 10.1136/gutjnl-2019-320105
   Weir TL, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0070803
   Wu HY, 2021, FRONT MED-LAUSANNE, V8, DOI 10.3389/fmed.2021.787228
   Wu HY, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.646626
   Wu L, 2020, J NUTR, V150, P2687, DOI 10.1093/jn/nxaa222
   Xia JF, 2022, MICROBIOL SPECTR, V10, DOI 10.1128/spectrum.01596-21
   Yan J, 2021, GUT MICROBES, V13, DOI 10.1080/19490976.2021.1984104
   Yassour M, 2016, GENOME MED, V8, DOI 10.1186/s13073-016-0271-6
   Zackular JP, 2013, MBIO, V4, DOI 10.1128/mBio.00692-13
   Zhang M, 2020, MOL NUTR FOOD RES, V64, DOI 10.1002/mnfr.201901105
   Zhang T, 2019, MICROB BIOTECHNOL, V12, P1109, DOI 10.1111/1751-7915.13410
   Zhou KQ, 2017, J FUNCT FOODS, V33, P194, DOI 10.1016/j.jff.2017.03.045
NR 63
TC 0
Z9 0
U1 18
U2 18
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1664-302X
J9 FRONT MICROBIOL
JI Front. Microbiol.
PD NOV 10
PY 2022
VL 13
AR 1037708
DI 10.3389/fmicb.2022.1037708
PG 16
WC Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology
GA 6N0HI
UT WOS:000889242200001
PM 36439840
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Deng, XR
   Zhang, CH
   Wang, PX
   Wei, W
   Shi, XY
   Wang, PP
   Yang, JP
   Wang, LM
   Tang, SS
   Fang, YY
   Liu, YL
   Chen, YQ
   Zhang, Y
   Yuan, Q
   Shang, J
   Kan, QE
   Yang, HH
   Man, H
   Wang, DY
   Yuan, HJ
AF Deng, Xinru
   Zhang, Chenhong
   Wang, Pengxu
   Wei, Wei
   Shi, Xiaoyang
   Wang, Pingping
   Yang, Junpeng
   Wang, Limin
   Tang, Shasha
   Fang, Yuanyuan
   Liu, Yalei
   Chen, Yiqi
   Zhang, Yun
   Yuan, Qian
   Shang, Jing
   Kan, Quane
   Yang, Huihui
   Man, Hua
   Wang, Danyu
   Yuan, Huijuan
TI Cardiovascular Benefits of Empagliflozin Are Associated With Gut
   Microbiota and Plasma Metabolites in Type 2 Diabetes
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
DE cardiovascular disease; empagliflozin; gut microbiota; metabonomics;
   type 2 diabetes mellitus
ID LINOLEIC-ACID; RISK-FACTORS; DOUBLE-BLIND; METFORMIN; OUTCOMES; OBESITY;
   TRIAL
AB Context Cardiovascular benefits of empagliflozin in patients with type 2 diabetes mellitus (T2DM) have been reported; however, the underlying mechanism remains unknown. Objective We hypothesized that the cardiovascular benefits of empagliflozin are associated with altered gut microbiota and plasma metabolites, and that empagliflozin may be used as an initial treatment for patients with T2DM at risk of cardiovascular diseases (CVDs). Methods This randomized, open-label, 3-month, 2-arm clinical trial included 76 treatment-naive patients with T2DM and risk factors for CVD who were treated with either empagliflozin (10 mg/d, n = 40) or metformin (1700 mg/d, n = 36). We investigated changes in clinical parameters related to glucose metabolism and CVD risk factors, gut microbiota using 16S rRNA gene sequencing, and plasma metabolites using LC-MS. Results We found significant and similar reduction in HbA1c levels and alleviation of glucose metabolism in both groups. However, only empagliflozin improved CVD risk factors. Empagliflozin significantly reshaped the gut microbiota after 1 month of treatment; this alteration was maintained until the end of the trial. Empagliflozin increased the levels of plasma metabolites such as sphingomyelin, but reduced glycochenodeoxycholate, cis-aconitate, and uric acid levels. Concurrently, empagliflozin elevated levels of short-chain fatty acid-producing bacteria such as species from Roseburia, Eubacterium, and Faecalibacterium, and reduced those of several harmful bacteria including Escherichia-Shigella, Bilophila, and Hungatella. Conclusion Empagliflozin may be a superior initial therapy for patients with T2DM at risk of CVDs; its cardiovascular benefits may be associated with shifts in gut microbiota and plasma metabolites.
C1 [Deng, Xinru; Wang, Pengxu; Wei, Wei; Shi, Xiaoyang; Wang, Pingping; Yang, Junpeng; Wang, Limin; Tang, Shasha; Fang, Yuanyuan; Liu, Yalei; Chen, Yiqi; Zhang, Yun; Yuan, Qian; Shang, Jing; Kan, Quane; Yang, Huihui; Man, Hua; Wang, Danyu; Yuan, Huijuan] Zhengzhou Univ, Henan Prov Peoples Hosp, Henan Prov Key Med Lab Intestinal Microecol & Dia, Dept Endocrinol,Peoples Hosp, Zhengzhou 450003, Henan, Peoples R China.
   [Zhang, Chenhong] Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, State Key Lab Microbial Metab, Shanghai 200240, Peoples R China.
   [Zhang, Chenhong] Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, Minist Educ, Key Lab Syst Biomed, Shanghai 200240, Peoples R China.
C3 Zhengzhou University; Shanghai Jiao Tong University; Shanghai Jiao Tong
   University
RP Yuan, HJ (通讯作者)，Henan Prov Peoples Hosp, 7 Weiwu Rd, Zhengzhou 450003, Henan, Peoples R China.
EM hjyuan@zzu.edu.cn
RI zhang, chenhong/HCH-9822-2022
OI Deng, Xinru/0000-0003-3747-9310
FU National Natural Science Foundation of China [81970705]; Central Plains
   Thousand Talents Plan [204200510026]
FX The work was supported by the National Natural Science Foundation of
   China under Grant 81970705; and Central Plains Thousand Talents Plan
   under Grant 204200510026.
CR Amer Diabet Assoc, 2020, DIABETES CARE, V43, pS111, DOI [10.2337/dc20-s010, 10.2337/dc20-S010]
   American Diabetes Association, 2020, Diabetes Care, V43, pS98, DOI 10.2337/dc20-S009
   BLAND JM, 1995, BRIT MED J, V310, P446, DOI 10.1136/bmj.310.6977.446
   Boesmans L, 2018, MSYSTEMS, V3, DOI 10.1128/mSystems.00094-18
   Callahan BJ, 2016, NAT METHODS, V13, P581, DOI [10.1038/NMETH.3869, 10.1038/nmeth.3869]
   David LA, 2014, NATURE, V505, P559, DOI 10.1038/nature12820
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Deng X., 2022, DRYAD DATASET, DOI 10.5061/dryad.n8pk0p2wf
   Dzau VJ, 2006, CIRCULATION, V114, P2850, DOI 10.1161/CIRCULATIONAHA.106.655688
   Gao F, 2019, FRONT PHARMACOL, V10, DOI 10.3389/fphar.2019.01040
   Genoni A, 2020, EUR J NUTR, V59, P1845, DOI 10.1007/s00394-019-02036-y
   Gill SR, 2006, SCIENCE, V312, P1355, DOI 10.1126/science.1124234
   Hamer HM, 2008, ALIMENT PHARM THER, V27, P104, DOI 10.1111/j.1365-2036.2007.03562.x
   Henderson G, 2018, LANCET DIABETES ENDO, V6, P12, DOI 10.1016/S2213-8587(17)30404-7
   Huang JP, 2017, J DIABETES, V9, P936, DOI 10.1111/1753-0407.12505
   International Diabetes Federation, 2017, REC MAN TYP 2 DIAB P
   Kang JD, 2019, CELL CHEM BIOL, V26, P27, DOI 10.1016/j.chembiol.2018.10.003
   Kasahara K, 2018, NAT MICROBIOL, V3, P1461, DOI 10.1038/s41564-018-0272-x
   Kelly TN, 2016, CIRC RES, V119, P956, DOI 10.1161/CIRCRESAHA.116.309219
   Kim E, 2016, PHARMACOL BIOCHEM BE, V142, P85, DOI 10.1016/j.pbb.2016.01.006
   Klindworth Anna, 2013, Nucleic Acids Res, V41, pe1, DOI 10.1093/nar/gks808
   Lee DM, 2018, CARDIOVASC DIABETOL, V17, DOI 10.1186/s12933-018-0708-x
   Marangoni F, 2020, ATHEROSCLEROSIS, V292, P90, DOI 10.1016/j.atherosclerosis.2019.11.018
   McCreight LJ, 2016, DIABETOLOGIA, V59, P426, DOI 10.1007/s00125-015-3844-9
   Mills EL, 2018, NATURE, V556, P113, DOI 10.1038/nature25986
   Montandon SA, 2017, GENES-BASEL, V8, DOI 10.3390/genes8100250
   Moran-Ramos S, 2017, ARCH MED RES, V48, P735, DOI 10.1016/j.arcmed.2017.11.003
   Mueller NT, 2021, DIABETES CARE, V44, P1462, DOI 10.2337/dc20-2257
   Ndrepepa G, 2018, CLIN CHIM ACTA, V484, P150, DOI 10.1016/j.cca.2018.05.046
   Norris GH, 2017, NUTR REV, V75, P274, DOI 10.1093/nutrit/nux004
   Perrone-Filardi P, 2017, INT J CARDIOL, V241, P450, DOI 10.1016/j.ijcard.2017.03.089
   Pertiwi K, 2020, DIABETES CARE, V43, P358, DOI 10.2337/dc19-1483
   Pinaud L, 2018, TRENDS MICROBIOL, V26, P266, DOI 10.1016/j.tim.2018.01.010
   Pruesse E, 2012, BIOINFORMATICS, V28, P1823, DOI 10.1093/bioinformatics/bts252
   Riccardi G, 2017, LANCET DIABETES ENDO, V5, P929, DOI 10.1016/S2213-8587(17)30322-4
   Rieg T, 2018, DIABETOLOGIA, V61, P2079, DOI 10.1007/s00125-018-4654-7
   Sugimoto T, 2014, J BIOSCI BIOENG, V117, P563, DOI 10.1016/j.jbiosc.2013.10.020
   Sun LL, 2019, ACTA PHARM SIN B, V9, P702, DOI 10.1016/j.apsb.2019.02.004
   Tan J, 2014, ADV IMMUNOL, V121, P91, DOI 10.1016/B978-0-12-800100-4.00003-9
   van Bommel EJM, 2020, DIABETES METAB, V46, P164, DOI 10.1016/j.diabet.2019.11.005
   Wahlstrom A, 2016, CELL METAB, V24, P41, DOI 10.1016/j.cmet.2016.05.005
   Wang L, 2016, SCI REP-UK, V6, DOI [10.1038/srep38380, 10.1038/srep33251, 10.1038/srep20004]
   Weersma RK, 2020, GUT, V69, P1510, DOI 10.1136/gutjnl-2019-320204
   World Health Organization, 2020, DIAGNOSIS MANAGEMENT
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Xu JH, 2020, J DIABETES, V12, P224, DOI 10.1111/1753-0407.12986
   Zhang XY, 2017, DIABETES THER, V8, P293, DOI 10.1007/s13300-017-0226-y
   Zhao LP, 2013, NAT REV MICROBIOL, V11, P639, DOI 10.1038/nrmicro3089
   Zhou BF, 2002, BIOMED ENVIRON SCI, V15, P83
   Zinman B, 2016, NEW ENGL J MED, V374, P1094, DOI 10.1056/NEJMc1600827
NR 50
TC 14
Z9 14
U1 11
U2 19
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD JUN 16
PY 2022
VL 107
IS 7
BP 1888
EP 1896
DI 10.1210/clinem/dgac210
EA APR 2022
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 2D8NO
UT WOS:000784953300001
PM 35397165
OA Green Published, hybrid
DA 2023-06-08
ER

PT J
AU Wan, YT
   Zuo, T
AF Wan, Yating
   Zuo, Tao
TI Interplays between drugs and the gut microbiome
SO GASTROENTEROLOGY REPORT
LA English
DT Review
DE gut microbiota; microbiome; drug; metabolism; efficacy
ID PROTON PUMP INHIBITORS; FARNESOID X-RECEPTOR; MULTI-OMICS;
   PARKINSONS-DISEASE; L-DOPA; METFORMIN; GLUCOSE; DIGOXIN; INACTIVATION;
   METABOLISM
AB The gut microbiota is considered a key 'metabolic organ'. Its metabolic activities play essential roles complementary to the host metabolic functions. The interplays between gut microbes and commonly used non-antibiotic drugs have garnered substantial attention over the years. Drugs can reshape the gut microorganism communities and, vice versa, the diverse gut microbes can affect drug efficacy by altering the bioavailability and bioactivity of drugs. The metabolism of drugs by gut microbial action or by microbiota-host cometabolism can transform the drugs into various metabolites. Secondary metabolites produced from the gut microbial metabolism of drugs contribute to both the therapeutic benefits and the side effects. In view of the significant effect of the gut microbiota on drug efficiency and clinical outcomes, it is pivotal to explore the interactions between drugs and gut microbiota underlying medical treatments. In this review, we describe and summarize the complex bidirectional interplays between gut microbes and drugs. We also illustrate the gut-microbiota profile altered by non-antibiotic drugs, the impacts and consequences of microbial alteration, and the biochemical mechanism of microbes impacting drug effectiveness. Understanding how the gut microbes interact with drugs and influence the therapeutic efficacy will help in discovering diverse novel avenues of regulating the gut microbes to improve the therapeutic effects and clinical outcomes of a drug in precision.
C1 [Wan, Yating] Chinese Univ Hong Kong, Dept Med & Therapeut, Fac Med, Hong Kong, Peoples R China.
   [Zuo, Tao] Sun Yat Sen Univ, Guangdong Inst Gastroenterol, Affiliated Hosp 6, 26 Yuancun Erheng Rd, Guangzhou 510655, Guangdong, Peoples R China.
   [Zuo, Tao] Sun Yat Sen Univ, Ctr Gut Microbiota Res, Affiliated Hosp 6, Guangzhou, Guangdong, Peoples R China.
C3 Chinese University of Hong Kong; Sun Yat Sen University; Sun Yat Sen
   University
RP Zuo, T (通讯作者)，Sun Yat Sen Univ, Guangdong Inst Gastroenterol, Affiliated Hosp 6, 26 Yuancun Erheng Rd, Guangzhou 510655, Guangdong, Peoples R China.
EM zuot@mail.sysu.edu.cn
OI WAN, Yating/0000-0002-7823-6318; Zuo, Tao/0000-0001-8450-5281
FU Municipal Key Research and Development Program of Guangzhou
   [202206010014]; National Natural Science Foundation of China [82172323,
   32100134]; Sixth Affiliated Hospital of Sun Yat-sen University and Sun
   Yat-sen University, China
FX This work was supported by the Municipal Key Research and Development
   Program of Guangzhou [grant number 202206010014], the National Natural
   Science Foundation of China [grant numbers 82172323 and 32100134], and a
   joint seed fund from the Sixth Affiliated Hospital of Sun Yat-sen
   University and Sun Yat-sen University, China.
CR Bajaj JS, 2018, AM J GASTROENTEROL, V113, P1177, DOI 10.1038/s41395-018-0085-9
   Baur D, 2017, LANCET INFECT DIS, V17, P990, DOI 10.1016/S1473-3099(17)30325-0
   Bengmark S, 2013, PHARMACOL RES, V69, P87, DOI 10.1016/j.phrs.2012.09.002
   BERGMANN S, 1974, BRIT J CLIN PHARMACO, V1, P417, DOI 10.1111/j.1365-2125.1974.tb00280.x
   BONORA E, 1984, CURR MED RES OPIN, V9, P47, DOI 10.1185/03007998409109558
   Bradley CA, 2017, NAT REV ENDOCRINOL, V13, P440, DOI 10.1038/nrendo.2017.72
   Buffie CG, 2015, NATURE, V517, P205, DOI 10.1038/nature13828
   Buffie CG, 2013, NAT REV IMMUNOL, V13, P790, DOI 10.1038/nri3535
   Chen CP, 2005, DRUG METAB DISPOS, V33, P537, DOI 10.1124/dmd.104.002477
   Cox LM, 2018, NEUROTHERAPEUTICS, V15, P135, DOI 10.1007/s13311-017-0598-8
   Cussotto S, 2019, PSYCHOPHARMACOLOGY, V236, P1411, DOI 10.1007/s00213-019-5185-8
   Dawson SL, 2016, INT REV NEUROBIOL, V131, P325, DOI 10.1016/bs.irn.2016.08.009
   DOBKIN JF, 1983, SCIENCE, V220, P325
   Dobkin JF., 1986, PEDIATR CARDIOL, P1240
   Duran-Sandoval D, 2004, DIABETES, V53, P890, DOI 10.2337/diabetes.53.4.890
   Fasano A, 2013, MOVEMENT DISORD, V28, P1241, DOI 10.1002/mds.25522
   Forgacs I, 2008, BMJ-BRIT MED J, V336, P2, DOI 10.1136/bmj.39406.449456.BE
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Freedberg DE, 2015, GASTROENTEROLOGY, V149, P883, DOI 10.1053/j.gastro.2015.06.043
   GOLDMAN P, 1974, AM J CLIN NUTR, V27, P1348
   GOODWIN BL, 1978, XENOBIOTICA, V8, P629, DOI 10.3109/00498257809069575
   Greer RL, 2016, NAT COMMUN, V7, DOI 10.1038/ncomms13329
   Haiser HJ, 2014, GUT MICROBES, V5, P233, DOI 10.4161/gmic.27915
   Haiser HJ, 2013, SCIENCE, V341, P295, DOI 10.1126/science.1235872
   Hashim H, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0112330
   Holman R, 2007, Journ Annu Diabetol Hotel Dieu, P13
   Holmes E, 2011, TRENDS MICROBIOL, V19, P349, DOI 10.1016/j.tim.2011.05.006
   Holtzman CW, 2006, PHARMACOTHERAPY, V26, P1601, DOI 10.1592/phco.26.11.1601
   Hooper LV, 2001, SCIENCE, V292, P1115, DOI 10.1126/science.1058709
   Hu XM, 2021, THERANOSTICS, V11, P5778, DOI 10.7150/thno.55946
   Hundal RS, 2000, DIABETES, V49, P2063, DOI 10.2337/diabetes.49.12.2063
   Imhann F, 2016, GUT, V65, P740, DOI 10.1136/gutjnl-2015-310376
   Jackson MA, 2016, GUT, V65, P749, DOI 10.1136/gutjnl-2015-310861
   Kaddurah-Daouk R, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0025482
   Kelly JR, 2016, J PSYCHIATR RES, V82, P109, DOI 10.1016/j.jpsychires.2016.07.019
   Kim J, 2019, FRONT MICROBIOL, V10, DOI 10.3389/fmicb.2019.01947
   Leonard J, 2007, AM J GASTROENTEROL, V102, P2047, DOI 10.1111/j.1572-0241.2007.01275.x
   LINDENBAUM J, 1981, NEW ENGL J MED, V305, P789, DOI 10.1056/NEJM198110013051403
   Liu YH, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.00530
   Lloyd-Price J, 2019, NATURE, V569, P655, DOI 10.1038/s41586-019-1237-9
   Maier L, 2018, NATURE, V555, P623, DOI 10.1038/nature25979
   Matsubara T, 2013, MOL CELL ENDOCRINOL, V368, P17, DOI 10.1016/j.mce.2012.05.004
   Nagatsu T, 2009, PARKINSONISM RELAT D, V15, pS3, DOI 10.1016/S1353-8020(09)70004-5
   Napolitano A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100778
   Noack C, 2014, PARKINSONISM RELAT D, V20, P815, DOI 10.1016/j.parkreldis.2014.04.007
   Novakovic M, 2020, WORLD J CARDIOL, V12, P110, DOI 10.4330/wjc.v12.i4.110
   Palacios N, 2021, FRONT NEUROL, V12, DOI 10.3389/fneur.2021.574529
   PAPAVASILIOU PS, 1972, NEW ENGL J MED, V286, P8, DOI 10.1056/NEJM197201062860102
   Perry G, 1997, NEW ENGL J MED, V336, P525
   Prawitt J, 2011, DIABETES, V60, P1861, DOI 10.2337/db11-0030
   Prehn-Kristensen A, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0200728
   Reeve A, 2014, AGEING RES REV, V14, P19, DOI 10.1016/j.arr.2014.01.004
   Rekdal VM, 2019, SCIENCE, V364, P1055, DOI 10.1126/science.aau6323
   ROBERTSON LW, 1986, APPL ENVIRON MICROB, V51, P1300, DOI 10.1128/AEM.51.6.1300-1303.1986
   Sampson TR, 2016, CELL, V167, P1469, DOI 10.1016/j.cell.2016.11.018
   SANDLER M, 1971, NATURE, V229, P414, DOI 10.1038/229414a0
   Savage N, 2020, NATURE, V577, pS10, DOI 10.1038/d41586-020-00196-0
   Sherwin E, 2019, SCIENCE, V366, P587, DOI 10.1126/science.aar2016
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Stark CM, 2019, GUT, V68, P62, DOI 10.1136/gutjnl-2017-314971
   Sun CN, 2019, SAUDI PHARM J, V27, P1146, DOI 10.1016/j.jsps.2019.09.011
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Surmeier DJ, 2018, FEBS J, V285, P3657, DOI 10.1111/febs.14607
   van Kessel SP, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-08294-y
   Vernocchi P, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21103688
   VICK RL, 1957, J PHARMACOL EXP THER, V121, P330
   Vila AV, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-019-14177-z
   Walsh J, 2018, BRIT J PHARMACOL, V175, P4415, DOI 10.1111/bph.14366
   Wang L., 2018, LIPIDS HEALTH DIS, V17, P1
   Weyer C, 1999, J CLIN INVEST, V104, P787, DOI 10.1172/JCI7231
   Wolfe MM, 2018, PROTON PUMP INHIBITO
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Zheng P, 2016, MOL PSYCHIATR, V21, P786, DOI 10.1038/mp.2016.44
   Zhou WY, 2019, NATURE, V569, P663, DOI 10.1038/s41586-019-1236-x
NR 74
TC 4
Z9 5
U1 4
U2 16
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 2052-0034
J9 GASTROENTEROL REP
JI Gastroenterol. Rep.
PD JAN 25
PY 2022
VL 10
AR goac009
DI 10.1093/gastro/goac009
PG 8
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 0I5MG
UT WOS:000779464300001
PM 35401987
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Gao, K
   Yang, R
   Zhang, P
   Wang, ZY
   Jia, CX
   Zhang, FL
   Li, SJ
   Wang, JP
   Murtaza, G
   Xie, H
   Zhao, HH
   Wang, W
   Chen, JX
AF Gao, Kuo
   Yang, Ran
   Zhang, Pan
   Wang, Zhiyong
   Jia, Caixia
   Zhang, Feilong
   Li, Shaojing
   Wang, Jinping
   Murtaza, Ghulam
   Xie, Hua
   Zhao, Huihui
   Wang, Wei
   Chen, Jianxin
TI Effects of Qijian mixture on type 2 diabetes assessed by metabonomics,
   gut microbiota and network pharmacology
SO PHARMACOLOGICAL RESEARCH
LA English
DT Article
DE Type 2 diabetes; Mechanism of action; Molecular targets; Metabonomics;
   Gut microbiota; System pharmacology
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; ESCHERICHIA-COLI; MICE; OBESITY;
   CELLS; INFLAMMATION; ENDOTOXEMIA; PREVALENCE; BERBERINE
AB Qjjian mixture, a new traditional Chinese medicine (TCM) formula comprising of Astragalus membranaceus, Romulus euonymi, Coptis chinensis and Pueraria lobata, was designed to ameliorate the type 2 diabetes (T2D), and its safety and efficacy were evaluated in the research by metabonomics, gut micro biota and system pharmacology. To study the hypoglycemic effect of Qijian mixture, male KKay mice (28-30g, 8-9 week) and C57/BL6 mice (18-19 g, 8-9 week) were used. Thirty KKay diabetic mice were randomly distributed into 5 groups, abbreviated as Model group (Model), Low Qijian Mixture group (QJM(L)), High Qijian Mixture group (QJM(H)), Chinese Medicine (Gegen Qinlian Decoction) Positive group (GGQL), and Western Medicine (Metformin hydrochloride) Positive group (Metformin). C57/BL6 was considered as the healthy control group (Control). Moreover, a system pharmacology approach was utilized to assess the physiological targets involved in the action of Qijian mixture. There was no adverse drug reaction of Qijian mixture in the acute toxicity study and HE result, and, compared with Model group, Qijian mixture could modulate blood glycemic level safely and effectively. Callan Mixture was lesser effective than metformin hydrochloride; however, both showed similar hypoglycemic trend. Based on H-1 NMR based metabonomics study, the profoundly altered metabolites in Qijian mixture treatment group were identified. Qjjian mixture-related 55 proteins and 4 signaling pathways, including galactose metabolism, valine, leucine and isoleucine degradation metabolism, aminoacyl-tRNA biosynthesis metabolism and alanine, aspartate and glutamate metabolism pathways, were explored. The PCoA analysis of gut micro biota revealed that Qijian mixture treatment profoundly enriched bacteroidetes. In addition, the system pharmacology paradigm revealed that Qijian mixture acted through TP53, AKT1 and PPARA proteins. It was concluded that Qjjian mixture effectively alleviated T2D, and this effect was linked with the altered features of the metabolite profiles and the gut microbiota. (C) 2018 Elsevier Ltd. All rights reserved.
C1 [Gao, Kuo; Zhang, Pan; Jia, Caixia; Zhang, Feilong; Wang, Jinping; Murtaza, Ghulam; Xie, Hua; Zhao, Huihui; Wang, Wei; Chen, Jianxin] Beijing Univ Chinese Med, Bei San Huan East Rd, Beijing 100029, Peoples R China.
   [Yang, Ran] China Acad Chinese Med Sci, Guanganmen Hosp, Beijing 100053, Peoples R China.
   [Wang, Zhiyong] FengNing Chinese Med Hosp, Xin Feng North Rd, Fengning 068350, Peoples R China.
   [Li, Shaojing] China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing 100700, Peoples R China.
   [Murtaza, Ghulam] Chinese Acad Sci, Inst Automat, Beijing 100029, Peoples R China.
C3 Beijing University of Chinese Medicine; China Academy of Chinese Medical
   Sciences; Guang'anmen Hospital, CACMS; China Academy of Chinese Medical
   Sciences; Institute of Chinese Materia Medica, CACMS; Chinese Academy of
   Sciences; Institute of Automation, CAS
RP Zhao, HH; Wang, W; Chen, JX (通讯作者)，Beijing Univ Chinese Med, Bei San Huan East Rd, Beijing 100029, Peoples R China.
EM 515123134@QQ.com; sunnygirl-1986@163.com; zhangjian3428@126.com;
   1099525743@QQ.com; jcxcaixia@foxmail.com; delko@bucm.edu.cn;
   shaojingli2004@126.com; wjpbucm@163.com; ghulammurtaza@ciit.net.pk;
   xiehua1130@163.com; hh686@126.com; wangwei@bucm.edu.cn; CJX@bucm.edu.cn
OI Zhang, Jian/0000-0002-6585-2808
FU National Natural Science Foundation of China [81522051, 81470191,
   81530100, 81403368]; Postgraduate Project of Beijing University of
   Chinese Medicine [2015-JYB-XS044, 2016-JYB-XS007]; Innovation Team of
   Wei Wang in Beijing University of Chinese Medicine; Combined Traditional
   Chinese and Western Medicine Pharmacology (13 Common Construction)
FX This work was supported by the National Natural Science Foundation of
   China (no. 81522051, 81470191, 81530100 and 81403368), Postgraduate
   Project of Beijing University of Chinese Medicine (no. 2015-JYB-XS044
   and 2016-JYB-XS007), Innovation Team of Wei Wang in Beijing University
   of Chinese Medicine and Combined Traditional Chinese and Western
   Medicine Pharmacology (13 Common Construction) Hold by Wei Wang.
CR Adeva MM, 2012, AMINO ACIDS, V43, P171, DOI 10.1007/s00726-011-1088-7
   Amar J, 2011, EMBO MOL MED, V3, P559, DOI 10.1002/emmm.201100159
   Ashburner M, 2000, NAT GENET, V25, P25, DOI 10.1038/75556
   Butler AE, 2003, DIABETES, V52, P102, DOI 10.2337/diabetes.52.1.102
   Cani PD, 2007, DIABETOLOGIA, V50, P2374, DOI 10.1007/s00125-007-0791-0
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   Chen JX, 2016, SCI REP-UK, V6, DOI 10.1038/srep24383
   Chen Q, 2006, CHINESE MED PHARM RE, P107
   Choy K, 2013, J NUTR, V143, P878, DOI 10.3945/jn.112.172999
   Davis LMG, 2010, INT J FOOD MICROBIOL, V144, P285, DOI 10.1016/j.ijfoodmicro.2010.10.007
   Deng H, 2011, CHIN J EXP TRADIT ME, V17, P114
   Dvorakova M, 2017, PHARMACOL RES, V124, P126, DOI 10.1016/j.phrs.2017.08.002
   Fei N, 2013, ISME J, V7, P880, DOI 10.1038/ismej.2012.153
   Feng JH, 2010, NANOTECHNOLOGY, V21, DOI 10.1088/0957-4484/21/39/395101
   Hakansson A, 2011, NUTRIENTS, V3, P637, DOI 10.3390/nu3060637
   Hansana V, 2013, BMC PUBLIC HEALTH, V13, DOI 10.1186/1471-2458-13-617
   Hotamisligil GS, 2006, NATURE, V444, P860, DOI 10.1038/nature05485
   Janga SC, 2009, MOL BIOSYST, V5, P1536, DOI [10.1039/b908147j, 10.1039/B908147j]
   Jay MA, 2007, CURR DIABETES REV, V3, P33, DOI 10.2174/157339907779802067
   KHINMAUNGU, 1985, BMJ-BRIT MED J, V291, P1601, DOI 10.1136/bmj.291.6509.1601
   Kuhn M, 2014, NUCLEIC ACIDS RES, V42, pD401, DOI 10.1093/nar/gkt1207
   Kung CP, 2016, J ENDOCRINOL, V231, pR61, DOI 10.1530/JOE-16-0324
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Le Sage F, 2017, PHARMACOL RES, V119, P303, DOI 10.1016/j.phrs.2017.02.020
   Li C, 2016, SCI REP-UK, V6, DOI 10.1038/srep36949
   Li P, 2015, BIOINFORMATICS, V31, P2007, DOI 10.1093/bioinformatics/btv080
   Minamino T, 2009, NAT MED, V15, P1082, DOI 10.1038/nm.2014
   Mohammed A, 2013, TRANSL ONCOL, V6, P649, DOI 10.1593/tlo.13556
   OuYang D, 2011, APPL BIOCHEM BIOTECH, V165, P148, DOI 10.1007/s12010-011-9240-0
   Park DY, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0059470
   Park SG, 2008, P NATL ACAD SCI USA, V105, P11043, DOI 10.1073/pnas.0802862105
   Petry KG, 1998, TRENDS GENET, V14, P98, DOI 10.1016/S0168-9525(97)01379-6
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Qiu GZ, 2017, EXP BIOL MED, V242, P223, DOI 10.1177/1535370216657445
   RABBANI GH, 1987, J INFECT DIS, V155, P979, DOI 10.1093/infdis/155.5.979
   Ren ZZ, 2014, BIO-MED MATER ENG, V24, P1333, DOI 10.3233/BME-130936
   Ru JL, 2014, J CHEMINFORMATICS, V6, DOI 10.1186/1758-2946-6-13
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Sookoian S, 2012, WORLD J GASTROENTERO, V18, P3775, DOI 10.3748/wjg.v18.i29.3775
   Tang J, 2009, J ETHNOPHARMACOL, V126, P5, DOI 10.1016/j.jep.2009.08.009
   Tian N, 2013, METABOLOMICS, V9, P1228, DOI 10.1007/s11306-013-0535-8
   Troy EB, 2010, FRONT BIOSCI-LANDMRK, V15, P25, DOI 10.2741/3603
   Wang X, 2016, BIOCHEM BIOPH RES CO, V473, P428, DOI 10.1016/j.bbrc.2016.03.024
   Wang XJ, 2011, J PHARMACEUT BIOMED, V55, P859, DOI 10.1016/j.jpba.2011.01.042
   Wenting Z., 2013, 12 CHIN SOC END AC C
   Wenting Z., 2014, J BEIJING U TRAD CHI
   Whiting DR, 2011, DIABETES RES CLIN PR, V94, P311, DOI 10.1016/j.diabres.2011.10.029
   Wiklund P, 2016, SCI REP-UK, V6, DOI 10.1038/srep24540
   Xiao SM, 2014, FEMS MICROBIOL ECOL, V87, P357, DOI 10.1111/1574-6941.12228
   Xu J, 2015, ISME J, V9, P552, DOI 10.1038/ismej.2014.177
   Xu Y, 2013, JAMA-J AM MED ASSOC, V310, P948, DOI 10.1001/jama.2013.168118
   Yan B., 2014, CHIN J ETHNOMED ETHN, V13, P27
   Yang J, 2012, J BIOL CHEM, V287, P24795, DOI 10.1074/jbc.M112.344259
   Yang L, 2016, MOL ENDOCRINOL, V30, P361, DOI 10.1210/me.2015-1213
   Yao X, 2011, BMC SYST BIOL, V5, DOI 10.1186/1752-0509-5-79
   Zhang M, 2008, EXP DIABETES RES, DOI 10.1155/2008/704045
   Zhang QC, 2012, NATURE, V490, P556, DOI 10.1038/nature11503
   Zhang X, 2012, PLOS ONE, V7, DOI [10.1371/journal.pone.0040320, 10.1371/journal.pone.0042529]
   Zhang YF, 2008, J CLIN ENDOCR METAB, V93, P2559, DOI 10.1210/jc.2007-2404
   Zhao LC, 2012, J ETHNOPHARMACOL, V142, P647, DOI 10.1016/j.jep.2012.05.031
   Zhao LP, 2013, NAT REV MICROBIOL, V11, P639, DOI 10.1038/nrmicro3089
   Zhu RY, 2017, PHARMACOL RES, V122, P78, DOI 10.1016/j.phrs.2017.05.019
NR 62
TC 70
Z9 80
U1 15
U2 233
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-6618
J9 PHARMACOL RES
JI Pharmacol. Res.
PD APR
PY 2018
VL 130
BP 93
EP 109
DI 10.1016/j.phrs.2018.01.011
PG 17
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA GG9JN
UT WOS:000433016900009
PM 29391233
DA 2023-06-08
ER

PT J
AU Liu, HJ
   Qin, Y
   Li, K
   Li, M
   Yang, JH
   Tao, HL
   Tang, YH
   Yang, L
   Chen, S
   Liu, YR
   Yang, C
   Gao, WQ
   Sun, T
AF Liu, Huijuan
   Qin, Yuan
   Li, Kun
   Li, Meng
   Yang, Jiahuan
   Tao, Honglian
   Tang, Yuanhao
   Yang, Lan
   Chen, Shuang
   Liu, Yanrong
   Yang, Cheng
   Gao, Wenqing
   Sun, Tao
TI Potential type 2 diabetes mellitus drug HMPA promotes short-chain fatty
   acid production by improving carbon catabolite repression effect of gut
   microbiota
SO BRITISH JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE carbon catabolite repression (CCR) effect; gut microbiota; short-chain
   fatty acids (SCFAs); type 2 diabetes mellitus (T2DM)
ID INSULIN-RESISTANCE; PPAR-GAMMA; OBESITY; BACTERIA; INFLAMMATION;
   METAGENOME; RELEVANCE; METFORMIN; GUIDE; RATS
AB Background and Purpose Gut microbiota plays an important role in type 2 diabetes mellitus (T2DM) progression. From our previous work N-(4-Hydroxyphenethyl)-3-mercapto-2-methylpropanamide (HMPA) is a potential T2DM drug. We evaluated the effect of HMPA on gut microbiota and studied the molecular mechanism underlying HMPA's regulation of gut microbiota.
   Experimental Approach The pseudo germ-free (PGF) T2DM model and faecal microbiota transplantation method were used to study whether gut microbiota mediates the actions of HMPA. The composition of gut microbiota was detected by using 16S rRNA sequence. Short-chain fatty acids (SCFAs) content was detected by gas chromatography. The HMPA probe was synthesised for finding and identifying the target protein of HMPA. The effect of HMPA on the utilisation of carbon sources in Bifidobacterium was evaluated.
   Key Results HMPA has a slight effect on the PGF T2DM model. The gut microbiota changed by HMPA can also alleviate the symptoms of T2DM. HMPA can regulate gut microbiota structure, increase SCFAs production and reduce nitrate content in the intestinal tissues. The thickness of the mucus on colon tissues increases after HMPA treatment. The target protein of HMPA in gut microbiota is the nitrogen metabolism global transcriptional regulator (GlnR). HMPA promotes the utilisation of less preferred carbon source in the gut microbiota and increases the fermentation product of SCFAs.
   Conclusion and Implications HMPA plays a hypoglycaemic role through the gut microbiota. HMPA improves the carbon catabolite repression effect of gut microbiota and increases SCFAs production by targeting GlnR. GlnR may be a target for gut microbiota regulation.
C1 [Liu, Huijuan; Qin, Yuan; Li, Kun; Li, Meng; Yang, Jiahuan; Tao, Honglian; Tang, Yuanhao; Yang, Cheng; Sun, Tao] Nankai Univ, State Key Lab Med Chem Biol, Tianjin, Peoples R China.
   [Liu, Huijuan; Qin, Yuan; Li, Kun; Li, Meng; Yang, Jiahuan; Tao, Honglian; Tang, Yuanhao; Yang, Cheng; Sun, Tao] Nankai Univ, Coll Pharm, Tianjin, Peoples R China.
   [Liu, Huijuan; Gao, Wenqing] Tianjin Third Cent Hosp, Tianjin Key Lab Extracorporeal Life Support Crit, Tianjin, Peoples R China.
   [Liu, Huijuan; Yang, Lan; Chen, Shuang; Liu, Yanrong; Yang, Cheng] Tianjin Int Joint Acad Biomed, Tianjin Key Lab Early Druggabil Evaluat Innovat D, Tianjin, Peoples R China.
   [Liu, Huijuan; Yang, Lan; Chen, Shuang; Liu, Yanrong; Yang, Cheng] Tianjin Int Joint Acad Biomed, Tianjin Key Lab Mol Drug Res, Tianjin, Peoples R China.
   [Sun, Tao] Tianjin Med Univ, Tianjin Inst Digest Dis, Gen Hosp, Dept Gastroenterol & Hepatol, Tianjin, Peoples R China.
   [Qin, Yuan] Zhejiang Sci Tech Univ, Coll Life Sci & Med, Hangzhou, Peoples R China.
C3 Nankai University; Nankai University; Tianjin International Joint
   Academy of Biomedicine; Tianjin International Joint Academy of
   Biomedicine; Tianjin Medical University; Zhejiang Sci-Tech University
RP Yang, C; Sun, T (通讯作者)，Nankai Univ, State Key Lab Med Chem Biol, Tianjin, Peoples R China.; Yang, C; Sun, T (通讯作者)，Nankai Univ, Coll Pharm, Tianjin, Peoples R China.; Gao, WQ (通讯作者)，Tianjin Third Cent Hosp, Tianjin Key Lab Extracorporeal Life Support Crit, Tianjin, Peoples R China.
EM cheng.yang@nankai.edu.cn; gaowenqing0906@126.com; tao.sun@nankai.edu.cn
RI liu, hui/HTO-8112-2023
OI Qin, Yuan/0000-0002-5651-8293; Chen, Shuang/0000-0001-5254-6353
FU National Natural Science Foundation of China [81703581, 81972629,
   81871972, 81572838, 81872374]; Postdoctoral support scheme for
   innovative talents [BX20180150]; China Postdoctoral Science Foundation
   [2018M640228]; National Key Research and Development Program of China
   [2018YFA0507203]; Tianjin Science and Technology Committee
   [18PTSYJC00060]; Taishan Scholars Program of Shandong Province
   [tsqn201909193]; Fundamental Research Funds for the Central
   Universities, Nankai University; Chinese National Major Scientific and
   Technological Special Project for "Significant New Drugs Development"
   [SQ2018ZX090201, 2018ZX09736-005]
FX National Natural Science Foundation of China, Grant/Award Numbers:
   81703581, 81972629, 81871972, 81572838, 81872374; Postdoctoral support
   scheme for innovative talents, Grant/Award Number: BX20180150; Project
   funded by China Postdoctoral Science Foundation, Grant/Award Number:
   2018M640228; The National Key Research and Development Program of China,
   Grant/Award Number: 2018YFA0507203; Tianjin Science and Technology
   Committee, Grant/Award Number: 18PTSYJC00060; Taishan Scholars Program
   of Shandong Province, Grant/Award Number: tsqn201909193; Fundamental
   Research Funds for the Central Universities, Nankai University; Chinese
   National Major Scientific and Technological Special Project for
   "Significant New Drugs Development", Grant/Award Numbers:
   SQ2018ZX090201, 2018ZX09736-005
CR Alexander SPH, 2019, BRIT J PHARMACOL, V176, pS21, DOI 10.1111/bph.14748
   Alexander SPH, 2018, BRIT J PHARMACOL, V175, P407, DOI 10.1111/bph.14112
   Ang ZW, 2016, FRONT IMMUNOL, V7, DOI 10.3389/fimmu.2016.00028
   Armougom F, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0007125
   Bruckner R, 2002, FEMS MICROBIOL LETT, V209, P141
   Byndloss MX, 2017, SCIENCE, V357, P570, DOI 10.1126/science.aam9949
   Chatterjee S, 2017, LANCET, V389, P2239, DOI 10.1016/S0140-6736(17)30058-2
   Chen MY, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.02380
   Curtis MJ, 2018, BRIT J PHARMACOL, V175, P987, DOI 10.1111/bph.14153
   du Sert NP, 2020, BRIT J PHARMACOL, V177, P3617, DOI 10.1111/bph.15193
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Gorke B, 2008, NAT REV MICROBIOL, V6, P613, DOI 10.1038/nrmicro1932
   Gu YY, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-01682-2
   Kahn SE, 2006, NATURE, V444, P840, DOI 10.1038/nature05482
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Komaroff AL, 2017, JAMA-J AM MED ASSOC, V317, P355, DOI 10.1001/jama.2016.20099
   Langille MGI, 2013, NAT BIOTECHNOL, V31, P814, DOI 10.1038/nbt.2676
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Ley RE, 2006, NATURE, V444, P1022, DOI 10.1038/4441022a
   Li NN, 2014, BIOORG MED CHEM LETT, V24, P386, DOI 10.1016/j.bmcl.2013.10.068
   Li QZ, 2020, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00939
   Liao CH, 2015, P NATL ACAD SCI USA, V112, P15630, DOI 10.1073/pnas.1508465112
   Lilley E, 2020, BRIT J PHARMACOL, V177, P3611, DOI 10.1111/bph.15178
   Liu HJ, 2015, J PHARMACOL EXP THER, V353, P573, DOI 10.1124/jpet.115.223107
   Nicholson JK, 2012, SCIENCE, V336, P1262, DOI 10.1126/science.1223813
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Reikvam DH, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0017996
   Remely M, 2014, GENE, V537, P85, DOI 10.1016/j.gene.2013.11.081
   Rivera-Chavez F, 2016, CELL HOST MICROBE, V19, P443, DOI 10.1016/j.chom.2016.03.004
   Roelofsen H, 2010, BENEF MICROBES, V1, P433, DOI 10.3920/BM2010.0028
   Santacruz A, 2010, BRIT J NUTR, V104, P83, DOI 10.1017/S0007114510000176
   Schumacher MA, 2015, GENE DEV, V29, P451, DOI 10.1101/gad.254714.114
   Schwiertz A, 2010, OBESITY, V18, P190, DOI 10.1038/oby.2009.167
   Shao J, 2020, OXID MED CELL LONGEV, V2020, DOI 10.1155/2020/1805418
   Sharma AK, 2011, PHYTOTHER RES, V25, P1457, DOI 10.1002/ptr.3442
   Shi HB, 2012, J AM CHEM SOC, V134, P3001, DOI 10.1021/ja208518u
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Sireeratawong S, 2016, BMC COMPLEM ALTERN M, V16, DOI 10.1186/s12906-016-1236-4
   Stepensky D, 2002, DRUG METAB DISPOS, V30, P861, DOI 10.1124/dmd.30.8.861
   Tai NW, 2015, REV ENDOCR METAB DIS, V16, P55, DOI 10.1007/s11154-015-9309-0
   Nguyen TD, 2019, EUR J NUTR, V58, P1545, DOI 10.1007/s00394-018-1688-z
   Wang BX, 2014, CURR DIABETES REV, V10, P131, DOI 10.2174/1573399810666140508121012
   Wichmann A, 2013, CELL HOST MICROBE, V14, P582, DOI 10.1016/j.chom.2013.09.012
   Wong JMW, 2006, J CLIN GASTROENTEROL, V40, P235, DOI 10.1097/00004836-200603000-00015
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Xu Y, 2016, APPL ENVIRON MICROB, V82, P6819, DOI 10.1128/AEM.02117-16
   Yang Q, 2005, NATURE, V436, P356, DOI 10.1038/nature03711
   Yu LM, 2015, J PINEAL RES, V59, P376, DOI 10.1111/jpi.12269
   Zhang SM, 2019, TALANTA, V196, P249, DOI 10.1016/j.talanta.2018.12.049
   Zhang YL, 2015, J BIOL CHEM, V290, P14875, DOI 10.1074/jbc.M115.660969
   Zhao JD, 2019, EVID-BASED COMPL ALT, V2019, DOI 10.1155/2019/6976394
   Zhao LP, 2018, SCIENCE, V359, P1151, DOI 10.1126/science.aao5774
   Zhao P, 2013, MOL METAB, V2, P161, DOI 10.1016/j.molmet.2013.04.003
   Zhao Y, 2015, GEN COMP ENDOCR, V224, P228, DOI 10.1016/j.ygcen.2015.08.019
NR 54
TC 7
Z9 7
U1 11
U2 59
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0007-1188
EI 1476-5381
J9 BRIT J PHARMACOL
JI Br. J. Pharmacol.
PD FEB
PY 2021
VL 178
IS 4
BP 946
EP 963
DI 10.1111/bph.15338
EA JAN 2021
PG 18
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA QB8AY
UT WOS:000607379300001
PM 33284460
OA Bronze
DA 2023-06-08
ER

PT J
AU Liu, SQ
   Yin, XQ
   Hou, C
   Liu, XR
   Ma, HJ
   Zhang, XX
   Xu, MH
   Xie, Y
   Li, Y
   Wang, JB
AF Liu, Siqi
   Yin, Xueqian
   Hou, Chao
   Liu, Xinran
   Ma, Huijuan
   Zhang, Xiaoxuan
   Xu, Meihong
   Xie, Ying
   Li, Yong
   Wang, Junbo
TI As a Staple Food Substitute, Oat and Buckwheat Compound Has
   Health-Promoting Effects for Diabetic Rats
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE oat; buckwheat; dietary intervention; staple food; diabetes; glucose
   metabolism; gut microbiota
ID TARTARY BUCKWHEAT; GUT MICROBIOTA; DIETARY-FIBERS; TYPE-2; GLUCOSE;
   INSULIN; INFLAMMATION; BARLEY; MODEL; RISK
AB Dietary intervention is crucial for the prevention and control of diabetes. China has the largest diabetic population in the world, yet no one dietary strategy matches the eating habits of the Chinese people. To explore an effective and acceptable dietary pattern, this study uses oat and buckwheat compound (OBC) as a staple food substitute and explored its effects on diabetic Sprague-Dawley rats. The model of diabetic rats was established by combining high-calorie feed and streptozotocin (STZ) injection. The dietary intervention for the seven groups, including a normal control group, a model control group, a metformin control group, a wheat flour control group, and three OBC groups with different doses, started from the beginning of the experiment and lasted for 11 weeks, two consecutive injections of STZ in small doses were operated at the 6th week. General states, glucose metabolism, and lipid metabolism indexes were measured. Antioxidant and inflammatory indexes and pathologic changes of kidney and liver tissues were tested. Changes in kidney and ileum ultramicrostructure were detected. What's more, ileal epithelial tight junction proteins and gut microbiota were analyzed. Significant decreases in fasting blood glucose (FBG), glucose tolerance, serum insulin, and insulin resistance were observed in rats intervened with OBC, and these rats also showed a higher level of superoxide dismutase (SOD) together with improved lipid metabolism, attenuated inflammation, and liver and kidney injuries. In addition, in OBC groups, the intestinal barrier was improved, and the disturbance of gut microbiota was reduced. These results suggest that OBC has health-promoting effects for diabetic rats, and since oat and buckwheat are traditionally consumed grains in China, OBC could be a potential and easy-to-accept staple food substitute for the dietary pattern for Chinese.
C1 [Liu, Siqi; Yin, Xueqian; Hou, Chao; Liu, Xinran; Ma, Huijuan; Zhang, Xiaoxuan; Xu, Meihong; Li, Yong; Wang, Junbo] Peking Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Beijing, Peoples R China.
   [Xie, Ying] Peking Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Beijing, Peoples R China.
C3 Peking University; Peking University
RP Wang, JB (通讯作者)，Peking Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Beijing, Peoples R China.
EM bmuwjbxy@bjmu.edu.cn
FU Ministry of Science and Technology of the People's Republic of China
   [2017YFD0401202]
FX This research was funded by the Ministry of Science and Technology of
   the People's Republic of China, Grant Number 2017YFD0401202.
CR Adeshirlarijaney A, 2020, GUT MICROBES, V11, P253, DOI 10.1080/19490976.2020.1717719
   Amar J, 2008, AM J CLIN NUTR, V87, P1219, DOI 10.1093/ajcn/87.5.1219
   Boffetta P, 2014, BRIT J NUTR, V112, pS14, DOI 10.1017/S0007114514002268
   Boullier S, 2009, J IMMUNOL, V183, P5879, DOI 10.4049/jimmunol.0901838
   Calinoiu LF, 2018, NUTRIENTS, V10, DOI 10.3390/nu10111615
   Chao CT, 2018, NEPHROLOGY, V23, P117, DOI 10.1111/nep.12975
   Ejtahed HS, 2016, HORM METAB RES, V48, P349, DOI 10.1055/s-0042-107792
   Eriksen AK, 2020, AM J CLIN NUTR, V111, P864, DOI 10.1093/ajcn/nqaa026
   Gheibi S, 2017, BIOMED PHARMACOTHER, V95, P605, DOI 10.1016/j.biopha.2017.08.098
   Gomes AC, 2014, NUTR J, V13, DOI 10.1186/1475-2891-13-60
   Gurung M, 2020, EBIOMEDICINE, V51, DOI 10.1016/j.ebiom.2019.11.051
   He LX, 2016, FOOD FUNCT, V7, P1413, DOI 10.1039/c5fo01364j
   Hou YY, 2018, NUTRIENTS, V10, DOI 10.3390/nu10111565
   Khanna S, 2014, MAYO CLIN PROC, V89, P107, DOI 10.1016/j.mayocp.2013.10.011
   Kim SH, 2014, J APPL MICROBIOL, V117, P834, DOI 10.1111/jam.12573
   Kreft M, 2016, NUTR RES REV, V29, P30, DOI 10.1017/S0954422415000190
   Lappi J, 2013, CRIT REV FOOD SCI, V53, P631, DOI 10.1080/10408398.2010.550388
   Lee DG, 2016, ACTA PHARMACEUT, V66, P297, DOI 10.1515/acph-2016-0021
   Li WZ, 2020, WORLD J DIABETES, V11, P293, DOI 10.4239/wjd.v11.i7.293
   Li X, 2016, NUTRIENTS, V8, DOI 10.3390/nu8090549
   Louis S, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0149564
   Lu CL, 2017, PEERJ, V5, DOI 10.7717/peerj.4042
   Ninomiya K, 2018, NUTRIENTS, V10, DOI 10.3390/nu10101503
   Nowotny K, 2015, BIOMOLECULES, V5, P194, DOI 10.3390/biom5010194
   Perez-Ramirez IF, 2018, J SCI FOOD AGR, V98, P998, DOI 10.1002/jsfa.8548
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Qiu J, 2016, NUTR RES, V36, P1392, DOI 10.1016/j.nutres.2016.11.007
   Qiu J, 2016, THER CLIN RISK MANAG, V12, P1721, DOI 10.2147/TCRM.S123008
   Reed MJ, 2000, METABOLISM, V49, P1390, DOI 10.1053/meta.2000.17721
   Saeedi P, 2019, DIABETES RES CLIN PR, V157, DOI 10.1016/j.diabres.2019.107843
   Sakuma M, 2009, J CLIN BIOCHEM NUTR, V44, P151, DOI 10.3164/jcbn.08-232
   Shen XL, 2016, NUTRIENTS, V8, DOI 10.3390/nu8010039
   Tosh SM, 2020, NUTR REV, V78, P13, DOI 10.1093/nutrit/nuz085
   Vergidis P, 2017, EMERG INFECT DIS, V23, P510, DOI 10.3201/eid2303.160633
   Vinolo MAR, 2011, NUTRIENTS, V3, P858, DOI 10.3390/nu3100858
   Wang JB, 2019, MOLECULES, V24, DOI 10.3390/molecules24030558
   Wang-Fischer Y, 2018, J DIABETES RES, V2018, DOI 10.1155/2018/8054073
   Xue B, 2016, FOOD FUNCT, V7, P1501, DOI 10.1039/c5fo01438g
   Yoo JY, 2020, MICROORGANISMS, V8, DOI 10.3390/microorganisms8101587
   Yoshida N, 2018, CIRCULATION, V138, P2486, DOI 10.1161/CIRCULATIONAHA.118.033714
   Yu K, 2014, ASIA PAC J CLIN NUTR, V23, P210, DOI 10.6133/apjcn.2014.23.2.01
   Yuan Y, 2020, BIOMED PHARMACOTHER, V127, DOI 10.1016/j.biopha.2020.110182
   Zhang BB, 2018, J ETHNOPHARMACOL, V214, P83, DOI 10.1016/j.jep.2017.12.002
   Zhao LP, 2018, SCIENCE, V359, P1151, DOI 10.1126/science.aao5774
NR 44
TC 3
Z9 3
U1 5
U2 21
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD DEC 24
PY 2021
VL 8
AR 762277
DI 10.3389/fnut.2021.762277
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA YI6XE
UT WOS:000743988900001
PM 35004803
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Xie, C
   Huang, WK
   Young, RL
   Jones, KL
   Horowitz, M
   Rayner, CK
   Wu, TZ
AF Xie, Cong
   Huang, Weikun
   Young, Richard L.
   Jones, Karen L.
   Horowitz, Michael
   Rayner, Christopher K.
   Wu, Tongzhi
TI Role of Bile Acids in the Regulation of Food Intake, and Their
   Dysregulation in Metabolic Disease
SO NUTRIENTS
LA English
DT Review
DE bile acids; TGR-5; FXR; gastrointestinal hormones; energy intake; body
   weight; obesity; type 2 diabetes
AB Bile acids are cholesterol-derived metabolites with a well-established role in the digestion and absorption of dietary fat. More recently, the discovery of bile acids as natural ligands for the nuclear farnesoid X receptor (FXR) and membrane Takeda G-protein-coupled receptor 5 (TGR5), and the recognition of the effects of FXR and TGR5 signaling have led to a paradigm shift in knowledge regarding bile acid physiology and metabolic health. Bile acids are now recognized as signaling molecules that orchestrate blood glucose, lipid and energy metabolism. Changes in FXR and/or TGR5 signaling modulates the secretion of gastrointestinal hormones including glucagon-like peptide-1 (GLP-1) and peptide YY (PYY), hepatic gluconeogenesis, glycogen synthesis, energy expenditure, and the composition of the gut microbiome. These effects may contribute to the metabolic benefits of bile acid sequestrants, metformin, and bariatric surgery. This review focuses on the role of bile acids in energy intake and body weight, particularly their effects on gastrointestinal hormone secretion, the changes in obesity and T2D, and their potential relevance to the management of metabolic disorders.
C1 [Xie, Cong; Huang, Weikun; Young, Richard L.; Jones, Karen L.; Horowitz, Michael; Rayner, Christopher K.; Wu, Tongzhi] Univ Adelaide, Adelaide Med Sch, Ctr Res Excellence CRE Translating Nutr Sci Good, Adelaide, SA 5005, Australia.
   [Huang, Weikun] Univ Adelaide, Inst Photon & Adv Sensing, Sch Phys Sci, ARC Ctr Excellence Nanoscale BioPhoton, Adelaide, SA 5005, Australia.
   [Young, Richard L.] Lifelong Hlth Theme South Australian Hlth & Med R, Nutr Diabet & Gut Hlth, Adelaide, SA 5005, Australia.
   [Jones, Karen L.; Horowitz, Michael; Wu, Tongzhi] Royal Adelaide Hosp, Endocrine & Metab Unit, Adelaide, SA 5005, Australia.
   [Rayner, Christopher K.] Royal Adelaide Hosp, Dept Gastroenterol & Hepatol, Adelaide, SA 5005, Australia.
   [Wu, Tongzhi] Southeast Univ, Inst Diabet, Sch Med, Nanjing 210009, Peoples R China.
C3 University of Adelaide; University of Adelaide; Royal Adelaide Hospital;
   Royal Adelaide Hospital; Southeast University - China
RP Wu, TZ (通讯作者)，Univ Adelaide, Adelaide Med Sch, Ctr Res Excellence CRE Translating Nutr Sci Good, Adelaide, SA 5005, Australia.; Wu, TZ (通讯作者)，Royal Adelaide Hosp, Endocrine & Metab Unit, Adelaide, SA 5005, Australia.; Wu, TZ (通讯作者)，Southeast Univ, Inst Diabet, Sch Med, Nanjing 210009, Peoples R China.
EM c.xie@adelaide.edu.au; weikun.huang@adelaide.edu.au;
   richard.young@adelaide.edu.au; karen.jones@adelaide.edu.au;
   michael.horowitz@adelaide.edu.au; chris.rayner@adelaide.edu.au;
   tongzhi.wu@adelaide.edu.au
RI horowitz, michael/HJY-3337-2023; Horowitz, Michael/AAY-3397-2021
OI Horowitz, Michael/0000-0002-0942-0306; Xie, Cong/0000-0002-0054-9269;
   Young, Richard/0000-0001-5116-4951; Huang, Weikun/0000-0001-9400-3840;
   Wu, Tongzhi/0000-0003-1656-9210; Jones, Karen/0000-0002-1155-5816
FU Australia National Health and Medical Research Council (NHMRC)
   [1147333]; Diabetes Australia [Y20G-WUTO]; National Natural Science
   Foundation of China [81870561]; China Scholarship Council; University of
   Adelaide; Hospital Research Foundation; National Health and Medical
   Research Council of Australia [1147333] Funding Source: NHMRC
FX The authors' work in this area is supported by the Australia National
   Health and Medical Research Council (NHMRC ID: 1147333), Diabetes
   Australia (ID: Y20G-WUTO) and the National Natural Science Foundation of
   China (81870561). C.X. is supported by a postgraduate scholarship from
   the China Scholarship Council. KLJ is supported by a University of
   Adelaide William T Southcott Research Fellowship. TW is supported by a
   Mid-Career Fellowship from the Hospital Research Foundation.
CR Adeyemo MA, 2015, DIABETES OBES METAB, V17, P363, DOI 10.1111/dom.12426
   Adrian TE, 2012, DIABETOLOGIA, V55, P2343, DOI 10.1007/s00125-012-2593-2
   ADRIAN TE, 1993, GUT, V34, P1219, DOI 10.1136/gut.34.9.1219
   Ahmad NN, 2013, INT J OBESITY, V37, P1553, DOI 10.1038/ijo.2013.38
   Ahmad TR, 2019, NAT REV ENDOCRINOL, V15, P701, DOI 10.1038/s41574-019-0266-7
   Al-Dury S, 2018, FRONT PHARMACOL, V9, DOI 10.3389/fphar.2018.00931
   Albaugh VL, 2019, GASTROENTEROLOGY, V156, P1041, DOI 10.1053/j.gastro.2018.11.017
   Aleman JO, 2018, J TRANSL MED, V16, DOI 10.1186/s12967-018-1619-z
   Annaba F, 2010, AM J PHYSIOL-GASTR L, V299, pG898, DOI 10.1152/ajpgi.00139.2010
   Bahne E, 2018, JCI INSIGHT, V3, DOI 10.1172/jci.insight.93936
   Bays HE, 2008, ARCH INTERN MED, V168, P1975, DOI 10.1001/archinte.168.18.1975
   BENNION LJ, 1977, NEW ENGL J MED, V296, P1365, DOI 10.1056/NEJM197706162962401
   Bertaggia E, 2017, AM J PHYSIOL-ENDOC M, V313, pE121, DOI 10.1152/ajpendo.00409.2016
   Beysen C, 2012, DIABETOLOGIA, V55, P432, DOI 10.1007/s00125-011-2382-3
   Borg MJ, 2019, DIABETES OBES METAB, V21, P640, DOI 10.1111/dom.13567
   BRAY GA, 1968, LANCET, V1, P1066
   Brighton CA, 2015, ENDOCRINOLOGY, V156, P3961, DOI 10.1210/en.2015-1321
   Bronden A, 2018, DIABETES OBES METAB, V20, P362, DOI 10.1111/dom.13080
   Brufau G, 2010, HEPATOLOGY, V52, P1455, DOI 10.1002/hep.23831
   Calderon G, 2020, EBIOMEDICINE, V55, DOI 10.1016/j.ebiom.2020.102759
   Cariou B, 2011, NUTR METAB, V8, DOI 10.1186/1743-7075-8-48
   Chen LH, 2012, AM J PHYSIOL-ENDOC M, V302, pE68, DOI 10.1152/ajpendo.00323.2011
   Cheng ZCA, 2018, MED SCI MONITOR, V24, P7206, DOI 10.12659/MSM.912429
   Chiang JYL, 2013, COMPR PHYSIOL, V3, P1191, DOI 10.1002/cphy.c120023
   Christiansen CB, 2019, AM J PHYSIOL-GASTR L, V316, pG574, DOI 10.1152/ajpgi.00010.2019
   Coll AP, 2020, NATURE, V578, P444, DOI 10.1038/s41586-019-1911-y
   Day EA, 2019, NAT METAB, V1, P1202, DOI 10.1038/s42255-019-0146-4
   De Vuono S, 2019, OBES SURG, V29, P2517, DOI 10.1007/s11695-019-03877-6
   Ducastel S, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-019-56743-x
   Fang S, 2015, NAT MED, V21, P159, DOI 10.1038/nm.3760
   Fiorucci S, 2015, TRENDS MOL MED, V21, P702, DOI 10.1016/j.molmed.2015.09.001
   Fiorucci S, 2009, TRENDS PHARMACOL SCI, V30, P570, DOI 10.1016/j.tips.2009.08.001
   Flynn CR, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms8715
   Fonseca VA, 2008, DIABETES CARE, V31, P1479, DOI 10.2337/dc08-0283
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Fruhbeck G, 2015, NAT REV ENDOCRINOL, V11, P465, DOI 10.1038/nrendo.2015.84
   Fuchs CD, 2018, GUT, V67, P1683, DOI 10.1136/gutjnl-2017-314553
   Glicksman C, 2010, ANN CLIN BIOCHEM, V47, P482, DOI 10.1258/acb.2010.010040
   Goldberg RB, 2008, ARCH INTERN MED, V168, P1531, DOI 10.1001/archinte.168.14.1531
   Gomes AC, 2018, GUT MICROBES, V9, P308, DOI 10.1080/19490976.2018.1465157
   GOMEZ G, 1988, GASTROENTEROLOGY, V94, P1036, DOI 10.1016/0016-5085(88)90564-1
   Gomez-Ambrosi J, 2017, CLIN NUTR, V36, P861, DOI 10.1016/j.clnu.2016.04.027
   Graffner H, 2016, ALIMENT PHARM THER, V43, P303, DOI 10.1111/apt.13457
   Guida C, 2020, CLIN MED INSIGHTS-EN, V13, DOI 10.1177/1179551419892985
   Haeusler RA, 2016, J CLIN ENDOCR METAB, V101, P1935, DOI 10.1210/jc.2015-2583
   Haeusler RA, 2013, DIABETES, V62, P4184, DOI 10.2337/db13-0639
   Hansen M, 2016, DIABETES OBES METAB, V18, P571, DOI 10.1111/dom.12648
   Herrema H, 2008, CHEM PHYS LIPIDS, V154, pS59, DOI 10.1016/j.chemphyslip.2008.05.160
   Higuchi S, 2020, GUT, V69, P1620, DOI 10.1136/gutjnl-2019-319693
   Hodge RJ, 2013, CLIN PHARM DRUG DEV, V2, P213, DOI 10.1002/cpdd.34
   Ihunnah CA, 2011, BBA-MOL BASIS DIS, V1812, P956, DOI 10.1016/j.bbadis.2011.01.014
   Karhus ML, 2017, DIABETES OBES METAB, V19, P1214, DOI 10.1111/dom.12946
   Katsuma S, 2005, BIOCHEM BIOPH RES CO, V329, P386, DOI 10.1016/j.bbrc.2005.01.139
   Kawamata Y, 2003, J BIOL CHEM, V278, P9435, DOI 10.1074/jbc.M209706200
   Kitayama K, 2006, EUR J PHARMACOL, V539, P89, DOI 10.1016/j.ejphar.2006.04.005
   Koop I, 1996, GUT, V39, P661, DOI 10.1136/gut.39.5.661
   KUDCHODKAR BJ, 1977, AM J CLIN NUTR, V30, P1135, DOI 10.1093/ajcn/30.7.1135
   Kuhre RE, 2018, MOL METAB, V11, P84, DOI 10.1016/j.molmet.2018.03.007
   Kuipers F, 2014, NAT REV ENDOCRINOL, V10, P488, DOI 10.1038/nrendo.2014.60
   Lee SG, 2019, CLIN CHEM LAB MED, V57, P1218, DOI 10.1515/cclm-2018-0741
   Lefebvre P, 2009, PHYSIOL REV, V89, P147, DOI 10.1152/physrev.00010.2008
   Legry V, 2017, J CLIN ENDOCR METAB, V102, P3783, DOI 10.1210/jc.2017-01397
   Li K, 2020, MOL METAB, V37, DOI 10.1016/j.molmet.2020.100980
   Li PZ, 2019, J CELL PHYSIOL, V234, P12839, DOI 10.1002/jcp.27940
   Lu JL, 2021, DIABETES CARE, V44, P499, DOI 10.2337/dc20-0884
   Makishima M, 2002, SCIENCE, V296, P1313, DOI 10.1126/science.1070477
   Makishima M, 1999, SCIENCE, V284, P1362, DOI 10.1126/science.284.5418.1362
   Maruyama T, 2002, BIOCHEM BIOPH RES CO, V298, P714, DOI 10.1016/S0006-291X(02)02550-0
   McGavigan AK, 2017, GUT, V66, P226, DOI 10.1136/gutjnl-2015-309871
   Mertens KL, 2017, FRONT NEUROSCI-SWITZ, V11, DOI 10.3389/fnins.2017.00617
   Nakatani H, 2009, METABOLISM, V58, P1400, DOI 10.1016/j.metabol.2009.05.006
   Neuschwander-Tetri BA, 2015, LANCET, V385, P956, DOI 10.1016/S0140-6736(14)61933-4
   Nicholson JK, 2012, SCIENCE, V336, P1262, DOI 10.1126/science.1223813
   NORTHFIE.TC, 1973, GUT, V14, P513, DOI 10.1136/gut.14.7.513
   Parker HE, 2012, BRIT J PHARMACOL, V165, P414, DOI 10.1111/j.1476-5381.2011.01561.x
   Parks DJ, 1999, SCIENCE, V284, P1365, DOI 10.1126/science.284.5418.1365
   Patel K, 2020, HEPATOLOGY, V72, P58, DOI 10.1002/hep.31205
   Pathak P, 2018, HEPATOLOGY, V68, P1574, DOI 10.1002/hep.29857
   Prinz P, 2015, FRONT NEUROSCI-SWITZ, V9, DOI 10.3389/fnins.2015.00199
   Rao A, 2016, SCI TRANSL MED, V8, DOI 10.1126/scitranslmed.aaf4823
   Renner O, 2014, UNITED EUR GASTROENT, V2, P216, DOI 10.1177/2050640614527938
   Roberts RE, 2011, CLIN ENDOCRINOL, V74, P67, DOI 10.1111/j.1365-2265.2010.03886.x
   Rubino F, 2010, ANNU REV MED, V61, P393, DOI 10.1146/annurev.med.051308.105148
   Rudling M, 2015, BMC CARDIOVASC DISOR, V15, DOI 10.1186/s12872-015-0070-9
   Russell DW, 2003, ANNU REV BIOCHEM, V72, P137, DOI 10.1146/annurev.biochem.72.121801.161712
   Sansome DJ, 2020, DIABETES OBES METAB, V22, P141, DOI 10.1111/dom.13869
   Sato H, 2008, J MED CHEM, V51, P1831, DOI 10.1021/jm7015864
   Schadt HS, 2018, TOXICOL SCI, V163, P265, DOI 10.1093/toxsci/kfy031
   Setchell KDR, 1997, GASTROENTEROLOGY, V112, P226, DOI 10.1016/S0016-5085(97)70239-7
   Shang Q, 2010, AM J PHYSIOL-GASTR L, V298, pG419, DOI 10.1152/ajpgi.00362.2009
   SHIFFMAN ML, 1992, GASTROENTEROLOGY, V103, P214, DOI 10.1016/0016-5085(92)91115-K
   Smushkin G, 2013, DIABETES, V62, P1094, DOI 10.2337/db12-0923
   Sonne DP, 2016, J CLIN ENDOCR METAB, V101, P3002, DOI 10.1210/jc.2016-1607
   Sonne DP, 2014, EUR J ENDOCRINOL, V171, P407, DOI 10.1530/EJE-14-0309
   Sonne DP, 2014, EUR J ENDOCRINOL, V171, pR47, DOI 10.1530/EJE-14-0154
   Steiner C, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0025006
   Straniero S, 2017, J INTERN MED, V281, P507, DOI 10.1111/joim.12599
   Sugimoto-Kawabata K, 2013, J LIPID RES, V54, P1255, DOI 10.1194/jlr.M032839
   Sun EW, 2019, J CLIN ENDOCR METAB, V104, P2668, DOI 10.1210/jc.2018-02460
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Thomas C, 2008, NAT REV DRUG DISCOV, V7, P678, DOI 10.1038/nrd2619
   Thomas C, 2009, CELL METAB, V10, P167, DOI 10.1016/j.cmet.2009.08.001
   Tough IR, 2020, NEUROGASTROENT MOTIL, V32, DOI 10.1111/nmo.13943
   Trabelsi MS, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms8629
   Wagner M, 2005, HEPATOLOGY, V42, P420, DOI 10.1002/hep.20784
   Wang HB, 1999, MOL CELL, V3, P543, DOI 10.1016/S1097-2765(00)80348-2
   Wang WT, 2019, FRONT PHYSIOL, V10, DOI 10.3389/fphys.2019.00374
   Watanabe M, 2006, NATURE, V439, P484, DOI 10.1038/nature04330
   Watanabe M, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0038286
   Wei ML, 2020, EBIOMEDICINE, V55, DOI 10.1016/j.ebiom.2020.102766
   Wewalka M, 2014, J CLIN ENDOCR METAB, V99, P1442, DOI 10.1210/jc.2013-3367
   Wu H, 2020, CELL METAB, V32, P379, DOI 10.1016/j.cmet.2020.06.011
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Wu T, 2013, DIABETES OBES METAB, V15, P474, DOI 10.1111/dom.12043
   Wu TZ, 2014, DIABETES RES CLIN PR, V106, pE3, DOI 10.1016/j.diabres.2014.08.004
   Wu TZ, 2013, J CLIN ENDOCR METAB, V98, pE718, DOI 10.1210/jc.2012-3961
   Wu XY, 2020, JCI INSIGHT, V5, DOI 10.1172/jci.insight.132400
   Wu YL, 2013, J MED CHEM, V56, P5094, DOI 10.1021/jm400459m
   Xie C, 2017, DIABETES, V66, P613, DOI 10.2337/db16-0663
   Xie C, 2020, PHARMACEUTICS, V12, DOI 10.3390/pharmaceutics12090790
   Zaborska KE, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0200908
   Zhang X, 2016, OBES SURG, V26, P1565, DOI 10.1007/s11695-015-1925-y
   Zhang YQ, 2006, P NATL ACAD SCI USA, V103, P1006, DOI 10.1073/pnas.0506982103
   Zheng XJ, 2021, CELL METAB, V33, P791, DOI 10.1016/j.cmet.2020.11.017
   Zietak M, 2016, AM J PHYSIOL-ENDOC M, V310, pE346, DOI 10.1152/ajpendo.00485.2015
NR 125
TC 35
Z9 36
U1 7
U2 35
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD APR
PY 2021
VL 13
IS 4
AR 1104
DI 10.3390/nu13041104
PG 16
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA RS0QP
UT WOS:000643491400001
PM 33800566
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Liu, YF
   Lou, XY
AF Liu, Yanfen
   Lou, Xueyong
TI Type 2 diabetes mellitus-related environmental factors and the gut
   microbiota: emerging evidence and challenges
SO CLINICS
LA English
DT Review
DE Type 2 Diabetes Mellitus; Gut Microbiota; Environmental Factors
ID INCREASED INTESTINAL PERMEABILITY; ADIPOSE-TISSUE; OBESITY; METFORMIN;
   HOST; HEALTH; BIFIDOBACTERIA; METABOLITES; DYSBIOSIS; BACTERIA
AB The gut microbiota is a group of over 38 trillion bacterial cells in the human microbiota that plays an important role in the regulation of human metabolism through its symbiotic relationship with the host. Changes in the gut microbial ecosystem are associated with increased susceptibility to metabolic disease in humans. However, the composition of the gut microbiota in those with type 2 diabetes mellitus and in the pathogenesis of metabolic diseases is not well understood. This article reviews the relationship between environmental factors and the gut microbiota in individuals with type 2 diabetes mellitus. Finally, we discuss the goal of treating type 2 diabetes mellitus by modifying the gut microbiota and the challenges that remain in this area.
C1 [Liu, Yanfen; Lou, Xueyong] Jinhua Municipal Cent Hosp, Dept Endocrinol Jinhua, Jinhua 321000, Zhejiang, Peoples R China.
RP Lou, XY (通讯作者)，Jinhua Municipal Cent Hosp, Dept Endocrinol Jinhua, Jinhua 321000, Zhejiang, Peoples R China.
EM 1183622088@qq.com
CR [Anonymous], [No title captured]
   Antonela B, 2017, EXP CLIN ENDOCR DIAB, V125, P563, DOI 10.1055/s-0043-109000
   Aydin O, 2018, CURR DIABETES REP, V18, DOI 10.1007/s11892-018-1020-6
   Backhed F, 2004, P NATL ACAD SCI USA, V101, P15718, DOI 10.1073/pnas.0407076101
   Backhed F, 2005, SCIENCE, V307, P1915, DOI 10.1126/science.1104816
   Backhed F, 2015, CELL HOST MICROBE, V17, P690, DOI [10.1016/j.chom.2015.04.004, 10.1016/j.chom.2015.05.012]
   Backhed F, 2012, CELL HOST MICROBE, V12, P611, DOI 10.1016/j.chom.2012.10.012
   Bailey CJ, 2008, DIABETOLOGIA, V51, P1552, DOI 10.1007/s00125-008-1053-5
   Belkaid Y, 2014, CELL, V157, P121, DOI 10.1016/j.cell.2014.03.011
   Bested AC, 2013, GUT PATHOG, V5, DOI 10.1186/1757-4749-5-5
   Bleau C, 2015, DIABETES-METAB RES, V31, P545, DOI 10.1002/dmrr.2617
   Bosi E, 2006, DIABETOLOGIA, V49, P2824, DOI 10.1007/s00125-006-0465-3
   Boulange CL, 2016, GENOME MED, V8, DOI 10.1186/s13073-016-0303-2
   Brunkwall L, 2017, DIABETOLOGIA, V60, P943, DOI 10.1007/s00125-017-4278-3
   Buse JB, 2016, DIABETES CARE, V39, P198, DOI 10.2337/dc15-0488
   Cani PD, 2007, DIABETOLOGIA, V50, P2374, DOI 10.1007/s00125-007-0791-0
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   Cani PD, 2014, NAT REV ENDOCRINOL, V10, P74, DOI 10.1038/nrendo.2013.240
   Clarke G, 2014, MOL ENDOCRINOL, V28, P1221, DOI 10.1210/me.2014-1108
   Cox AJ, 2015, LANCET DIABETES ENDO, V3, P207, DOI 10.1016/S2213-8587(14)70134-2
   Cox LM, 2013, CELL METAB, V17, P883, DOI 10.1016/j.cmet.2013.05.004
   Crowther GS, 2015, INFECT DRUG RESIST, V8, P333, DOI 10.2147/IDR.S87224
   David LA, 2014, NATURE, V505, P559, DOI 10.1038/nature12820
   De Filippo C, 2010, P NATL ACAD SCI USA, V107, P14691, DOI 10.1073/pnas.1005963107
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   de Vrese M, 2008, ADV BIOCHEM ENG BIOT, V111, P1, DOI 10.1007/10_2008_097
   Dethlefsen L, 2011, P NATL ACAD SCI USA, V108, P4554, DOI 10.1073/pnas.1000087107
   Devaraj S, 2016, CLIN CHEM, V62, P1554, DOI 10.1373/clinchem.2016.256842
   Eid HM, 2017, FRONT PHARMACOL, V8, DOI 10.3389/fphar.2017.00387
   Endt K, 2010, PLOS PATHOG, V6, DOI 10.1371/journal.ppat.1001097
   Ferrer M, 2013, ENVIRON MICROBIOL, V15, P211, DOI 10.1111/j.1462-2920.2012.02845.x
   Finlayson A, 2015, WORLD J GASTRO ENDOS, V7, P1103, DOI [10.4253/wjge.v7.i13.1103, 10.4291/wjgp.v6.i4.110]
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Fukuda S, 2012, GUT MICROBES, V3, P449, DOI [10.4161.gmic.21214, 10.4161/gmic.21214]
   Gevers D, 2014, CELL HOST MICROBE, V15, P382, DOI 10.1016/j.chom.2014.02.005
   Gholizadeh P, 2019, MICROB PATHOGENESIS, V127, P48, DOI 10.1016/j.micpath.2018.11.031
   Gibson GR, 2004, NUTR RES REV, V17, P259, DOI 10.1079/NRR200479
   Grasset E, 2017, CELL METAB, V25, P1075, DOI 10.1016/j.cmet.2017.04.013
   Greenway F, 2014, BENEF MICROBES, V5, P29, DOI 10.3920/BM2012.0063
   Gu YY, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-01682-2
   Guariguata L, 2014, DIABETES RES CLIN PR, V103, P137, DOI 10.1016/j.diabres.2013.11.002
   Hamer HM, 2008, ALIMENT PHARM THER, V27, P104, DOI 10.1111/j.1365-2036.2007.03562.x
   Hartstra AV, 2015, DIABETES CARE, V38, P159, DOI 10.2337/dc14-0769
   Henschel AM, 2018, PLOS ONE, V13, DOI [10.1371/journal.pone.0190351, 10.1371/journal.pone.019035]
   Jaacks LM, 2016, BEST PRACT RES CL EN, V30, P331, DOI 10.1016/j.beem.2016.05.003
   Kadooka Y, 2010, EUR J CLIN NUTR, V64, P636, DOI 10.1038/ejcn.2010.19
   Kiela PR, 2016, BEST PRACT RES CL GA, V30, P145, DOI 10.1016/j.bpg.2016.02.007
   Koenig JE, 2011, P NATL ACAD SCI USA, V108, P4578, DOI 10.1073/pnas.1000081107
   Kovatcheva-Datchary P, 2015, CELL METAB, V22, P971, DOI 10.1016/j.cmet.2015.10.001
   Kuitunen M, 2002, AUTOIMMUNITY, V35, P365, DOI 10.1080/0891693021000008526
   Kumar H, 2014, MBIO, V5, DOI 10.1128/mBio.02113-14
   Langenberg C, 2018, LANCET, V391, P2463, DOI 10.1016/S0140-6736(18)31132-2
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Le KA, 2013, FRONT PHYSIOL, V3, DOI 10.3389/fphys.2012.00496
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Ley RE, 2005, P NATL ACAD SCI USA, V102, P11070, DOI 10.1073/pnas.0504978102
   Ley RE, 2006, NATURE, V444, P1022, DOI 10.1038/4441022a
   Liou AP, 2013, SCI TRANSL MED, V5, DOI 10.1126/scitranslmed.3005687
   Longo D., 2012, HARRISONS PRINCIPLES
   Lorente-Cebrian S, 2019, CLIN SCI, V133, P23, DOI 10.1042/CS20180890
   Martinez I, 2013, ISME J, V7, P269, DOI 10.1038/ismej.2012.104
   Maynard CL, 2012, NATURE, V489, P231, DOI 10.1038/nature11551
   Medina DA, 2017, PEERJ, V5, DOI 10.7717/peerj.3443
   MOORADIAN AD, 1986, DIABETOLOGIA, V29, P221, DOI 10.1007/BF00454879
   Moroti C, 2012, LIPIDS HEALTH DIS, V11, DOI 10.1186/1476-511X-11-29
   Nadal I, 2009, INT J OBESITY, V33, P758, DOI 10.1038/ijo.2008.260
   Napolitano A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100778
   Nicholson JK, 2012, SCIENCE, V336, P1262, DOI 10.1126/science.1223813
   Pascale A, 2018, ENDOCRINE, V61, P357, DOI 10.1007/s12020-018-1605-5
   Perry RJ, 2016, NATURE, V534, P213, DOI 10.1038/nature18309
   Plovier H, 2017, NAT MED, V23, P107, DOI 10.1038/nm.4236
   Postler TS, 2017, CELL METAB, V26, P110, DOI 10.1016/j.cmet.2017.05.008
   Qin JJ, 2010, NATURE, V464, P59, DOI 10.1038/nature08821
   Rahat-Rozenbloom S, 2014, INT J OBESITY, V38, P1525, DOI 10.1038/ijo.2014.46
   Sapone A, 2006, DIABETES, V55, P1443, DOI 10.2337/db05-1593
   Sartor RB, 2017, GASTROENTEROLOGY, V152, P327, DOI 10.1053/j.gastro.2016.10.012
   Sato J, 2014, DIABETES CARE, V37, P2343, DOI 10.2337/dc13-2817
   Scott KP, 2013, PHARMACOL RES, V69, P52, DOI 10.1016/j.phrs.2012.10.020
   Secondulfo M, 2004, DIGEST LIVER DIS, V36, P35, DOI 10.1016/j.dld.2003.09.016
   Sender R, 2016, PLOS BIOL, V14, DOI 10.1371/journal.pbio.1002533
   Shapiro H, 2017, J DIABETES, V9, P226, DOI 10.1111/1753-0407.12501
   Sharon G, 2014, CELL METAB, V20, P719, DOI 10.1016/j.cmet.2014.10.016
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Singh RK, 2017, J TRANSL MED, V15, DOI 10.1186/s12967-017-1175-y
   Slavin J, 2013, NUTRIENTS, V5, P1417, DOI 10.3390/nu5041417
   Slyepchenko A, 2016, CURR PHARM DESIGN, V22, P6087, DOI 10.2174/1381612822666160922165706
   Sommer F, 2013, NAT REV MICROBIOL, V11, P227, DOI 10.1038/nrmicro2974
   Spor A, 2011, NAT REV MICROBIOL, V9, P279, DOI 10.1038/nrmicro2540
   Su BL, 2015, J DIABETES, V7, P729, DOI 10.1111/1753-0407.12232
   Tabuchi M, 2003, BIOSCI BIOTECH BIOCH, V67, P1421, DOI 10.1271/bbb.67.1421
   Tap J, 2015, ENVIRON MICROBIOL, V17, P4954, DOI 10.1111/1462-2920.13006
   Tian PJ, 2016, FOOD FUNCT, V7, P3789, DOI [10.1039/c6fo00831c, 10.1039/C6FO00831C]
   Tremaroli V, 2012, NATURE, V489, P242, DOI 10.1038/nature11552
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Turnbaugh PJ, 2009, NATURE, V457, P480, DOI 10.1038/nature07540
   Underhill DM, 2016, NAT REV IMMUNOL, V16, P651, DOI 10.1038/nri.2016.89
   Viaud S, 2013, SCIENCE, V342, P971, DOI 10.1126/science.1240537
   Viner R, 2017, LANCET, V389, P2252, DOI 10.1016/S0140-6736(17)31371-5
   Vogt SL, 2015, ANAEROBE, V34, P106, DOI 10.1016/j.anaerobe.2015.05.002
   Wu GD, 2011, SCIENCE, V334, P105, DOI 10.1126/science.1208344
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Xiao L, 2015, NAT BIOTECHNOL, V33, P1103, DOI 10.1038/nbt.3353
   Yan XF, 2016, J DIABETES RES, V2016, DOI 10.1155/2016/2093171
   Yang M, 2017, AM J PHYSIOL-GASTR L, V312, pG367, DOI 10.1152/ajpgi.00232.2016
   Yang XZ, 2017, J AGR FOOD CHEM, V65, P7168, DOI 10.1021/acs.jafc.7b01964
   Ye JP, 2013, FRONT MED-PRC, V7, P14, DOI 10.1007/s11684-013-0262-6
   Zhang Q, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0184735
NR 107
TC 14
Z9 15
U1 3
U2 28
PU ELSEVIER ESPANA
PI MADRID
PA CALLE DE ZURBANO, 76-4TH FLR LEFT, MADRID, 28010, SPAIN
SN 1807-5932
EI 1980-5322
J9 CLINICS
JI Clinics
PY 2020
VL 75
AR e1277
DI 10.6061/clinics/2020/e1277
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA KB9GG
UT WOS:000506794400001
PM 31939557
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Wang, YM
   Dilidaxi, D
   Wu, YC
   Sailike, J
   Sun, X
   Nabi, XH
AF Wang, Yanming
   Dilidaxi, Dinareer
   Wu, Yuche
   Sailike, Jialehasibieke
   Sun, Xin
   Nabi, Xin-hua
TI Composite probiotics alleviate type 2 diabetes by regulating intestinal
   microbiota and inducing GLP-1 secretion in db/db mice
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Diabetes 2 mellitus; Composite probiotics; Gut microbiota; Short-chain
   fatty acids; Glucagon-like peptide-1
ID GLUCAGON-LIKE PEPTIDE-1; GUT MICROBIOTA; INFLAMMATORY RESPONSES; INSULIN
   SENSITIVITY; FAT DIET; GLUCOSE; MECHANISMS; EXPRESSION; RECEPTOR;
   OBESITY
AB Backgroud/Aim: Previous studies have found that probiotic fermented camel milk has anti-diabetic effect by inducing (glucagon-like peptide-1) GLP-1 secretion. Probiotics are valuable in prevention and treatment of diabetes. As a result, our team islolated 14 probiotics from fermented camel milk. These probiotics have beneficial characteristics, but the possible anti-diabetic mechanisms remains unclear. The present study aimed to explore the possoble anti-diabetic mechanisms of 14 probiotics.
   Methods: C57BL/Ks mice were normal group. The db/db mice were randomized into five groups: model group, metformin group, liraglutide group, low-dose and high-dose probiotic group. Biochemical parameters were determined by the respective assay kits. The levels of the short-chain fatty acids (SCFAs) and microbiota were respectively determined by gas chromatography and qRT-PCR. HE staining and immunofluorescence were used for histomorphological observation. Quantitative PCR and western-blot were determined the gene and protein expression of Bax, Bcl-2, Caspase-3 and PI3K/AKT.
   Results: Probiotics significantly improved blood glucose and blood lipid parameters, as well as the morphological changes of pancreas, liver and kidney. Probiotics improved the gut barrier function through increasing the levels of SCFA-producing bacteria and SCFAs as well as the expression of claudin-1 and mucin-2, and decreasing Escherichia coli and LPS level. In additon, probiotics enhanced insulin secretion through glucose-triggered GLP-1 secretion by upregulating G protein-coupled receptor 43/41 (GPR43/41), proglucagon and proconvertase 1/3 activity. Forthermore, probiotics protected pancreas against apoptosis, which may be dependent on the upregulation of PI3K/AKT pathway.
   Conclusions: The anti-diabetic effect of 14 probiotics in db/db mice seem to be related to an increase of SCFA-producing bacteria, the improvement of intestinal barrier function and the upregulation of GLP-1 production, and indicate these probiotics might be a good candidate to prevent and treat diabetes.
C1 [Wang, Yanming; Dilidaxi, Dinareer; Wu, Yuche; Sailike, Jialehasibieke; Sun, Xin; Nabi, Xin-hua] Xinjiang Med Univ, Dept Pharmacol, Urumqi 830011, Peoples R China.
C3 Xinjiang Medical University
RP Nabi, XH (通讯作者)，Xinjiang Med Univ, Dept Pharmacol, Urumqi 830011, Peoples R China.
EM xinhuanabi@yeah.net
FU University Scientific Research Plan of Xinjiang Uygur Autonomous Region,
   China [XJEDU2020I012]; Graduate Innovation and Entrepreneurship Project
   of Xinjiang Uygur Autonomous Region, China [XJ2019G177]
FX This project was supported by the funds from University Scientific
   Research Plan of Xinjiang Uygur Autonomous Region, China (XJEDU2020I012)
   and Graduate Innovation and Entrepreneurship Project of Xinjiang Uygur
   Autonomous Region, China (XJ2019G177).
CR [Anonymous], CHINA MICROECOLOGY J
   [Anonymous], 2019, NUTRIENTS
   Aoki R, 2017, SCI REP-UK, V7, DOI 10.1038/srep43522
   Bagarolli RA, 2017, J NUTR BIOCHEM, V50, P16, DOI 10.1016/j.jnutbio.2017.08.006
   Balakumar M, 2018, EUR J NUTR, V57, P279, DOI 10.1007/s00394-016-1317-7
   Cheng Q, 2011, J MOL ENDOCRINOL, V47, P13, DOI 10.1530/JME-10-0106
   Dalboge LS, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0082813
   Dolpady J, 2016, J DIABETES RES, V2016, DOI 10.1155/2016/7569431
   Garcia-Mazcorro JF, 2018, PEERJ, V6, DOI 10.7717/peerj.4195
   Hansen CHF, 2019, DIABETOLOGIA, V62, P1689, DOI 10.1007/s00125-019-4910-5
   Hendijani F, 2018, CLIN NUTR, V37, P532, DOI 10.1016/j.clnu.2017.02.015
   Hsieh FC, 2013, NUTR METAB, V10, DOI 10.1186/1743-7075-10-35
   HUMMEL KP, 1966, SCIENCE, V153, P1127, DOI 10.1126/science.153.3740.1127
   Islam MS, 2013, J DIABETES RES, V2013, DOI 10.1155/2013/149452
   Jang SE, 2014, INT IMMUNOPHARMACOL, V21, P186, DOI 10.1016/j.intimp.2014.04.021
   Jetton TL, 2005, DIABETES, V54, P2294, DOI 10.2337/diabetes.54.8.2294
   Kim KH, 2018, FRONT PHARMACOL, V9, DOI 10.3389/fphar.2018.01071
   Kimura I, 2020, PHYSIOL REV, V100, P171, DOI 10.1152/physrev.00041.2018
   Kondylis V, 2017, IMMUNOL REV, V277, P113, DOI 10.1111/imr.12550
   Kothari D, 2019, BIOMED PHARMACOTHER, V111, P537, DOI 10.1016/j.biopha.2018.12.104
   Le Barz M, 2015, DIABETES METAB J, V39, P291, DOI 10.4093/dmj.2015.39.4.291
   Lee HA, 2016, J MICROBIOL BIOTECHN, V26, P469, DOI 10.4014/jmb.1511.11001
   Lee YS, 2014, METABOLISM, V63, P9, DOI 10.1016/j.metabol.2013.09.010
   Li KK, 2017, J FUNCT FOODS, V38, P561, DOI 10.1016/j.jff.2017.09.049
   Li NF, 2012, BMC PUBLIC HEALTH, V12, DOI 10.1186/1471-2458-12-499
   Liang YJ, 2019, PROBIOTICS ANTIMICRO, V11, P175, DOI 10.1007/s12602-017-9378-3
   Liu YX, 2015, J ETHNOPHARMACOL, V166, P168, DOI 10.1016/j.jep.2015.03.014
   Lu SS, 2009, J ENDOCRINOL, V200, P159, DOI 10.1677/JOE-08-0419
   Manaer T, 2015, J ETHNOPHARMACOL, V169, P269, DOI 10.1016/j.jep.2015.04.032
   Maslowski KM, 2009, NATURE, V461, P1282, DOI 10.1038/nature08530
   Mekkes MC, 2014, BENEF MICROBES, V5, P19, DOI 10.3920/BM2012.0069
   Miao W, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17101696
   Miyamoto J, 2019, P NATL ACAD SCI USA, V116, P23813, DOI 10.1073/pnas.1912573116
   Miyamoto J, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0196579
   Morimoto K, 2016, ENDOCRINOLOGY, V157, P1071, DOI 10.1210/en.2015-1551
   Muller TD, 2018, PHARMACOL REV, V70, P712, DOI 10.1124/pr.117.014803
   Munoz-Garach A, 2016, ENDOCRINOL NUTR, V63, P560, DOI 10.1016/j.endonu.2016.07.008
   O'Malley TJ, 2014, DIABETES-METAB RES, V30, P661, DOI 10.1002/dmrr.2534
   Payne AN, 2011, NUTR DIABETES, V1, DOI 10.1038/nutd.2011.8
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Rastelli M, 2018, OBESITY, V26, P792, DOI 10.1002/oby.22175
   Rohden F, 2014, OBES SURG, V24, P2075, DOI 10.1007/s11695-014-1279-x
   Rojas A, 2019, EXPERT OPIN THER TAR, V23, P1, DOI 10.1080/14728222.2019.1554056
   Sailike J., 2019, Zhongguo Weishengtaxixue Zazhi / Chinese Journal of Microecology, V31, P502
   Samuel BS, 2008, P NATL ACAD SCI USA, V105, P16767, DOI 10.1073/pnas.0808567105
   Sanders ME, 2019, NAT REV GASTRO HEPAT, V16, P605, DOI 10.1038/s41575-019-0173-3
   Sedighi M, 2017, MICROB PATHOGENESIS, V111, P362, DOI 10.1016/j.micpath.2017.08.038
   Seo S, 2017, J FUNCT FOODS, V29, P256, DOI 10.1016/j.jff.2016.12.045
   Shaw JE, 2010, DIABETES RES CLIN PR, V87, P4, DOI 10.1016/j.diabres.2009.10.007
   Shen B, 2019, BIOMED PHARMACOTHER, V114, DOI 10.1016/j.biopha.2019.108849
   Singh S, 2017, BENEF MICROBES, V8, P243, DOI 10.3920/BM2016.0090
   Timper K, 2016, GASTROENTEROLOGY, V151, P165, DOI 10.1053/j.gastro.2016.03.003
   Tojo R, 2014, WORLD J GASTROENTERO, V20, P15163, DOI 10.3748/wjg.v20.i41.15163
   Wang LF, 2010, J CLIN HYPERTENS, V12, P741, DOI 10.1111/j.1751-7176.2010.00349.x
   Wang L, 2016, SCI REP-UK, V6, DOI [10.1038/srep38380, 10.1038/srep33251, 10.1038/srep20004]
   Wang LL, 2017, J CHROMATOGR B, V1057, P70, DOI 10.1016/j.jchromb.2017.05.004
   Wang W, 2014, J CLIN MICROBIOL, V52, P398, DOI 10.1128/JCM.01500-13
   Xu JH, 2020, J DIABETES, V12, P224, DOI 10.1111/1753-0407.12986
   Yan WL, 2015, ETHNIC HEALTH, V20, P365, DOI 10.1080/13557858.2014.921894
   Yoo JY, 2016, NUTRIENTS, V8, DOI 10.3390/nu8030173
   You WJ, 2018, J CELL BIOCHEM, V119, P8547, DOI 10.1002/jcb.27095
   Zhang J, 2017, GUT PATHOG, V9, DOI 10.1186/s13099-017-0160-6
   Zhang Q, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0184735
NR 63
TC 82
Z9 91
U1 24
U2 115
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD MAY
PY 2020
VL 125
AR 109914
DI 10.1016/j.biopha.2020.109914
PG 11
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA KU2DX
UT WOS:000519520000026
PM 32035395
OA gold
DA 2023-06-08
ER

PT J
AU Mezhibovsky, E
   Knowles, KA
   He, QY
   Sui, K
   Tveter, KM
   Duran, RM
   Roopchand, DE
AF Mezhibovsky, Esther
   Knowles, Kim A.
   He, Qiyue
   Sui, Ke
   Tveter, Kevin M.
   Duran, Rocio M.
   Roopchand, Diana E.
TI Grape Polyphenols Attenuate Diet-Induced Obesity and Hepatic Steatosis
   in Mice in Association With Reduced Butyrate and Increased Markers of
   Intestinal Carbohydrate Oxidation
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE hepatic steatosis; energy expenditure; Akkermansia muciniphila;
   butyrate; intestinal metabolism; Western diet; grape polyphenols; short
   chain fatty acids
ID CHAIN FATTY-ACIDS; ENERGY-EXPENDITURE; AKKERMANSIA-MUCINIPHILA;
   GLUCOSE-METABOLISM; GUT MICROBIOME; PROPIONATE; EXPRESSION; METFORMIN;
   LIVER; PROANTHOCYANIDINS
AB A Western Diet (WD) low in fiber but high in fats and sugars contributes to obesity and non-alcoholic fatty liver disease (NAFLD). Supplementation with grape polyphenols (GPs) rich in B-type proanthocyanidins (PACs) can attenuate symptoms of cardiometabolic disease and alter the gut microbiota and its metabolites. We hypothesized that GP-mediated metabolic improvements would correlate with altered microbial metabolites such as short chain fatty acids (SCFAs). To more closely mimic a WD, C57BL/6J male mice were fed a low-fiber diet high in sucrose and butterfat along with 20% sucrose water to represent sugary beverages. This WD was supplemented with 1% GPs (WD-GP) to investigate the impact of GPs on energy balance, SCFA profile, and intestinal metabolism. Compared to WD-fed mice, the WD-GP group had higher lean mass along with lower fat mass, body weight, and hepatic steatosis despite consuming more calories from sucrose water. Indirect and direct calorimetry revealed that reduced adiposity in GP-supplemented mice was likely due to their greater energy expenditure, which resulted in lower energy efficiency compared to WD-fed mice. GP-supplemented mice had higher abundance of Akkermansia muciniphila, a gut microbe reported to increase energy expenditure. Short chain fatty acid measurements in colon content revealed that GP-supplemented mice had lower concentrations of butyrate, a major energy substrate of the distal intestine, and reduced valerate, a putrefactive SCFA. GP-supplementation also resulted in a lower acetate:propionate ratio suggesting reduced hepatic lipogenesis. Considering the higher sucrose consumption and reduced butyrate levels in GP-supplemented mice, we hypothesized that enterocytes would metabolize glucose and fructose as a replacement energy source. Ileal mRNA levels of glucose transporter-2 (GLUT2, SLC2A2) were increased indicating higher glucose and fructose uptake. Expression of ketohexokinase (KHK) was increased in ileum tissue suggesting increased fructolysis. A GP-induced increase in intestinal carbohydrate oxidation was supported by: (1) increased gene expression of duodenal pyruvate dehydrogenase (PDH), (2) a decreased ratio of lactate dehydrogenase a (LDHa): LDHb in jejunum and colon tissues, and (3) decreased duodenal and colonic lactate concentrations. These data indicate that GPs protect against WD-induced obesity and hepatic steatosis by diminishing portal delivery of lipogenic butyrate and sugars due to their increased intestinal utilization.
C1 [Mezhibovsky, Esther; Knowles, Kim A.; He, Qiyue; Sui, Ke; Tveter, Kevin M.; Duran, Rocio M.; Roopchand, Diana E.] Rutgers Ctr Lipid Res, Dept Food Sci, New Brunswick, NJ 08901 USA.
   [Mezhibovsky, Esther; Knowles, Kim A.; He, Qiyue; Sui, Ke; Tveter, Kevin M.; Duran, Rocio M.; Roopchand, Diana E.] Rutgers Ctr Lipid Res, New Jersey Inst Food Nutr & Hlth, New Brunswick, NJ 08901 USA.
   [Mezhibovsky, Esther; Knowles, Kim A.; He, Qiyue; Sui, Ke; Tveter, Kevin M.; Duran, Rocio M.; Roopchand, Diana E.] Ctr Nutr Microbiome & Hlth, New Brunswick, NJ 08901 USA.
   [Mezhibovsky, Esther] Rutgers State Univ, Dept Nutr Sci, Grad Program, New Brunswick, NJ USA.
C3 Rutgers State University New Brunswick; Rutgers State University New
   Brunswick; Rutgers State University New Brunswick
RP Roopchand, DE (通讯作者)，Rutgers Ctr Lipid Res, Dept Food Sci, New Brunswick, NJ 08901 USA.; Roopchand, DE (通讯作者)，Rutgers Ctr Lipid Res, New Jersey Inst Food Nutr & Hlth, New Brunswick, NJ 08901 USA.; Roopchand, DE (通讯作者)，Ctr Nutr Microbiome & Hlth, New Brunswick, NJ 08901 USA.
EM roopchand@sebs.rutgers.edu
FU Robert T. Rosen Memorial scholarship; Ruth L. Kirschstein NRSA
   Predoctoral Fellowship [F31 AT010981]; NIH-NCCIH [R01 AT010242]
FX This work was supported by a Robert T. Rosen Memorial scholarship to EM,
   a Ruth L. Kirschstein NRSA Predoctoral Fellowship (F31 AT010981) to KMT,
   and NIH-NCCIH Grant R01 AT010242 to DER.
CR Anhe FF, 2019, GUT, V68, P453, DOI 10.1136/gutjnl-2017-315565
   [Anonymous], 1907, NATURE, V7, P1
   Aprikian O, 2003, J NUTR, V133, P1860, DOI 10.1093/jn/133.6.1860
   Atlantis E, 2009, METABOLISM, V58, P1013, DOI 10.1016/j.metabol.2009.02.027
   Aura AM, 2013, EUR J NUTR, V52, P833, DOI 10.1007/s00394-012-0391-8
   Baumann A, 2020, NUTRIENTS, V12, DOI 10.3390/nu12040951
   Bazzocco S, 2008, EUR J NUTR, V47, P442, DOI 10.1007/s00394-008-0747-2
   Berggren AM, 1996, BRIT J NUTR, V76, P287, DOI 10.1079/BJN19960032
   BERGMAN EN, 1990, PHYSIOL REV, V70, P567, DOI 10.1152/physrev.1990.70.2.567
   Berna G, 2020, LIVER INT, V40, P102, DOI 10.1111/liv.14360
   Blouin JM, 2011, INT J CANCER, V128, P2591, DOI 10.1002/ijc.25599
   Bournat Juan C, 2010, Curr Opin Endocrinol Diabetes Obes, V17, P446, DOI 10.1097/MED.0b013e32833c3026
   Butler AA, 2010, DIABETES, V59, P323, DOI 10.2337/db09-1471
   Casanova-Marti A, 2018, FOOD FUNCT, V9, P1672, DOI [10.1039/c7fo02028g, 10.1039/C7FO02028G]
   CHAPMAN MAS, 1995, BRIT J SURG, V82, P36, DOI 10.1002/bjs.1800820115
   Choi MS, 2015, BRIT J NUTR, V113, P867, DOI 10.1017/S0007114515000100
   Dao MC, 2019, AM J PHYSIOL-ENDOC M, V317, pE446, DOI 10.1152/ajpendo.00140.2019
   de la Cuesta-Zuluaga J, 2019, NUTRIENTS, V11, DOI 10.3390/nu11010051
   De Vadder F, 2014, CELL, V156, P84, DOI 10.1016/j.cell.2013.12.016
   den Besten G, 2013, AM J PHYSIOL-GASTR L, V305, pG900, DOI 10.1152/ajpgi.00265.2013
   Depommier C, 2020, GUT MICROBES, V11, P1231, DOI 10.1080/19490976.2020.1737307
   Ejtahed HS, 2019, EUR J ENDOCRINOL, V180, P165, DOI [10.1530/EJE-18-0826, 10.1530/eje-18-0826]
   Fernandes J, 2014, NUTR DIABETES, V4, DOI 10.1038/nutd.2014.23
   Fotschki B, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0149081
   Gao ZG, 2009, DIABETES, V58, P1509, DOI 10.2337/db08-1637
   Garcia-Villalba R, 2012, J SEP SCI, V35, P1906, DOI 10.1002/jssc.201101121
   Hosseini E, 2011, NUTR REV, V69, P245, DOI 10.1111/j.1753-4887.2011.00388.x
   Huart J, 2019, HYPERTENSION, V74, P1005, DOI 10.1161/HYPERTENSIONAHA.118.12588
   Isnard S, 2020, OPEN FORUM INFECT DI, V7, DOI 10.1093/ofid/ofaa338
   Jang C, 2018, CELL METAB, V27, P351, DOI 10.1016/j.cmet.2017.12.016
   Jensen T, 2018, J HEPATOL, V68, P1063, DOI 10.1016/j.jhep.2018.01.019
   Jha D, 2019, MOL BIOL REP, V46, P1727, DOI 10.1007/s11033-019-04623-y
   Cires MJ, 2019, FOOD FUNCT, V10, P4022, DOI [10.1039/C9FO00700H, 10.1039/c9fo00700h]
   Kaiyala KJ, 2011, DIABETES, V60, P17, DOI 10.2337/db10-0909
   Kellett GL, 2005, DIABETES, V54, P3056, DOI 10.2337/diabetes.54.10.3056
   Koffert JP, 2017, DIABETES RES CLIN PR, V131, P208, DOI 10.1016/j.diabres.2017.07.015
   Kopp W, 2019, DIABET METAB SYND OB, V12, P2221, DOI 10.2147/DMSO.S216791
   Kuhn P, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0198716
   Lenzen S, 1996, BIOCHEM PHARMACOL, V51, P893, DOI 10.1016/0006-2952(95)02243-0
   Li LY, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-12087-8
   Li M, 2014, BENEF MICROBES, V5, P335, DOI 10.3920/BM2013.0071
   Li Q, 2019, NUTRIENTS, V11, DOI 10.3390/nu11051017
   LIN YG, 1995, BRIT J NUTR, V74, P197, DOI 10.1079/BJN19950123
   Lukovac S, 2014, MBIO, V5, DOI 10.1128/mBio.01438-14
   Miao ZH, 2020, BIOSCI BIOTECH BIOCH, V84, P411, DOI 10.1080/09168451.2019.1676696
   Nagata R, 2018, BIOSCI BIOTECH BIOCH, V82, P489, DOI 10.1080/09168451.2018.1429886
   Ou KQ, 2014, J FUNCT FOODS, V7, P43, DOI 10.1016/j.jff.2013.08.004
   Pimpin L, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0158118
   Rahat-Rozenbloom S, 2014, INT J OBESITY, V38, P1525, DOI 10.1038/ijo.2014.46
   Rau M, 2018, UNITED EUR GASTROENT, V6, P1496, DOI 10.1177/2050640618804444
   Regnier M, 2020, NUTRIENTS, V12, DOI 10.3390/nu12102932
   Roopchand DE, 2015, DIABETES, V64, P2847, DOI 10.2337/db14-1916
   Roopchand DE, 2013, J AGR FOOD CHEM, V61, P11428, DOI 10.1021/jf403238e
   Rusli F, 2016, SCI REP-UK, V6, DOI 10.1038/srep30484
   Saeidi N, 2013, SCIENCE, V341, P406, DOI 10.1126/science.1235103
   Sandoval-Acuna C, 2014, ARCH BIOCHEM BIOPHYS, V559, P75, DOI 10.1016/j.abb.2014.05.017
   Schommers P, 2017, MOL METAB, V6, P737, DOI 10.1016/j.molmet.2017.05.002
   Schwiertz A, 2010, OBESITY, V18, P190, DOI 10.1038/oby.2009.167
   Shaidullov IF, 2021, BMC GASTROENTEROL, V21, DOI 10.1186/s12876-021-01613-y
   Stefan N, 2008, ENDOCR REV, V29, P939, DOI 10.1210/er.2008-0009
   Teixeira TFS, 2013, BRIT J NUTR, V109, P914, DOI 10.1017/S0007114512002723
   Turnbaugh PJ, 2008, CELL HOST MICROBE, V3, P213, DOI 10.1016/j.chom.2008.02.015
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Tveter KM, 2020, BMJ OPEN DIAB RES CA, V8, DOI 10.1136/bmjdrc-2020-001386
   Vallon V, 2017, DIABETOLOGIA, V60, P215, DOI 10.1007/s00125-016-4157-3
   Villa-Rodriguez JA, 2019, ADV NUTR, V10, P999, DOI 10.1093/advances/nmz038
   Yu J., 2016, J HEALTH SCI, V4, P167, DOI [10.17265/2328-7136/2016.04.001, DOI 10.17265/2328-7136/2016.04.001]
   Zambell KL, 2003, J NUTR, V133, P3509, DOI 10.1093/jn/133.11.3509
   Zarrinpar A, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-018-05336-9
   Zhan K, 2020, J DAIRY SCI, V103, P5514, DOI 10.3168/jds.2019-17309
   Zhang HW, 2013, J AGR FOOD CHEM, V61, P8814, DOI 10.1021/jf402518k
   Zhang L, 2018, J NUTR BIOCHEM, V56, P142, DOI 10.1016/j.jnutbio.2018.02.009
   Zhao LP, 2018, SCIENCE, V359, P1151, DOI 10.1126/science.aao5774
NR 73
TC 15
Z9 15
U1 9
U2 40
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD JUN 14
PY 2021
VL 8
AR 675267
DI 10.3389/fnut.2021.675267
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA TA1VX
UT WOS:000667043400001
PM 34195217
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Wang, S
   Li, XY
   Shen, L
AF Wang, Sai
   Li, Xin-Yu
   Shen, Liang
TI Modulation effects of Dendrobium officinale on gut microbiota of type 2
   diabetes model mice
SO FEMS MICROBIOLOGY LETTERS
LA English
DT Article
DE Dendrobium officinale; type 2 diabetes; gut microbiota; Akkermansia
ID AKKERMANSIA-MUCINIPHILA; INTESTINAL MICROBIOTA; METFORMIN; INFLAMMATION;
   KIMURA; ADULTS; MIGO
AB In recent years, the relationship between type 2 diabetes (T2D) and gut microbiota has attracted much interest. Dendrobium officinale is a valuable traditional Chinese medicine (TCM) with anti-T2D potential, while its action mechanism remains to be further studied. This study was designed to investigate the modulation effects of D. officinale on gut microbiota of T2D model mice to provide clues to its pharmacology by high-throughput sequencing techniques. It was found that D. officinale supplement could significantly reduce the fasting blood glucose levels of T2D mice. Dendrobium officinale supplement could modulate the composition of gut microbiota and increase the relative abundances of key bacterial taxa associated with T2D development, including Akkermansia and Parabacteroides. Compared with placebo group mice, several Kyoto Encyclopedia of Gene and Genomes pathways associated with T2D altered in the D. officinale treated group. These findings indicated the modulation of D. officinale on gut microbiota of T2D mice, which provide potential pharmacological implications.
C1 [Wang, Sai; Li, Xin-Yu; Shen, Liang] Shandong Univ Technol, Inst Biomed Res, 266 Xincun West Rd, Zibo 255000, Shandong, Peoples R China.
   [Wang, Sai; Li, Xin-Yu; Shen, Liang] Shandong Univ Technol, Shandong Prov Res Ctr Bioinformat Engn & Tech, Sch Life Sci, Zibo 255000, Shandong, Peoples R China.
C3 Shandong University of Technology; Shandong University of Technology
RP Shen, L (通讯作者)，Shandong Univ Technol, Inst Biomed Res, 266 Xincun West Rd, Zibo 255000, Shandong, Peoples R China.
EM shen@sdut.edu.cn
CR Backhed F, 2005, SCIENCE, V307, P1915, DOI 10.1126/science.1104816
   Belzer C, 2012, ISME J, V6, P1449, DOI 10.1038/ismej.2012.6
   Tonucci L, 2017, CRIT REV FOOD SCI, V57, P2296, DOI 10.1080/10408398.2014.934438
   Collado MC, 2007, APPL ENVIRON MICROB, V73, P7767, DOI 10.1128/AEM.01477-07
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Feng WW, 2019, PHARMACOL RES, V142, P176, DOI 10.1016/j.phrs.2019.02.024
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   International Diabetes Federation, IDF DIABETES ATLAS
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Li XW, 2018, MOLECULES, V23, DOI 10.3390/molecules23123245
   Liou AP, 2013, SCI TRANSL MED, V5, DOI 10.1126/scitranslmed.3005687
   Liu CZ, 2020, CHIN J NAT MEDICINES, V18, P446, DOI 10.1016/S1875-5364(20)30052-2
   Palau-Rodriguez M, 2015, FRONT MICROBIOL, V6, DOI [10.3339/fmicb.2075.07751, 10.3389/fmicb.2015.01151]
   Pan LH, 2014, INT J BIOL MACROMOL, V64, P420, DOI 10.1016/j.ijbiomac.2013.12.024
   Plovier H, 2017, NAT MED, V23, P107, DOI 10.1038/nm.4236
   Scalbert A, 2000, J NUTR, V130, p2073S, DOI 10.1093/jn/130.8.2073S
   Shen L, 2016, TRENDS PHARMACOL SCI, V37, P169, DOI 10.1016/j.tips.2015.11.010
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Su HM, 2020, OXID MED CELL LONGEV, V2020, DOI 10.1155/2020/6538930
   Tang HX, 2017, EVID-BASED COMPL ALT, V2017, DOI 10.1155/2017/7436259
   Tilg H, 2014, GUT, V63, P1513, DOI 10.1136/gutjnl-2014-306928
   Verdam FJ, 2013, OBESITY, V21, pE607, DOI 10.1002/oby.20466
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Wu XM, 2019, NAT PROD REP, V36, P788, DOI 10.1039/c8np00041g
   Yue SJ, 2019, PHARMACOL RES, V148, DOI 10.1016/j.phrs.2019.104453
   Zhang ZH, 2016, BIOMED PHARMACOTHER, V84, P1350, DOI 10.1016/j.biopha.2016.10.074
   Zhao SQ, 2017, J MOL ENDOCRINOL, V58, P1, DOI 10.1530/JME-16-0054
NR 30
TC 4
Z9 5
U1 10
U2 59
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0378-1097
EI 1574-6968
J9 FEMS MICROBIOL LETT
JI FEMS Microbiol. Lett.
PD MAR
PY 2021
VL 368
IS 5
AR fnab020
DI 10.1093/femsle/fnab020
EA FEB 2021
PG 5
WC Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology
GA RX3DI
UT WOS:000647106000005
PM 33606020
DA 2023-06-08
ER

PT J
AU Feng, YW
   Cao, H
   Hua, J
   Zhang, F
AF Feng, Yuwei
   Cao, Hong
   Hua, Jiao
   Zhang, Feng
TI Anti-Diabetic Intestinal Mechanisms: Foods, Herbs, and Western Medicines
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Review
DE foods; gut microbiota; herbs; type 2 diabetes mellitus; Western
   medicines
ID TYPE-2 DIABETES-MELLITUS; GUT MICROBIOTA; AKKERMANSIA-MUCINIPHILA;
   COMMENSAL BACTERIA; PROGNOSTIC VALUE; DOUBLE-BLIND; METFORMIN; ACARBOSE;
   OBESITY; DAPAGLIFLOZIN
AB The role of intestinal factors in the pathogenesis of diabetes, such as a decrease in the incretin effect, has recently attracted considerable attention. An imbalance in the gut microbiota inhibits the secretion of incretins, which are metabolic hormones can reduce blood glucose levels, and promotes the occurrence and development of diabetes. Numerous studies have demonstrated that foods are environmental factors that are important in the modulation of gut microbial-mediated glucose metabolism. In general, functional foods trigger the gut microbiota to produce beneficial metabolites or reduce harmful products through metabolic pathways and then regulate glucose and lipid metabolism. Recent studies have shown that similar to functional foods, the regulatory effects of some herbs and Western medicines are closely related to alterations in the gut microbiota. In this review, the intestinal mechanism of foods, herbs, and Western medicine in affecting the process of glucose metabolism is summarized.
C1 [Feng, Yuwei; Cao, Hong; Zhang, Feng] Jiangnan Univ, Affiliated Hosp, Nutr Dept, Wuxi 214122, Jiangsu, Peoples R China.
   [Feng, Yuwei; Cao, Hong; Hua, Jiao; Zhang, Feng] Jiangnan Univ, Wuxi Sch Med, Wuxi 214122, Jiangsu, Peoples R China.
   [Cao, Hong; Zhang, Feng] Jiangnan Univ, Affiliated Hosp, Clin Assessment Ctr Funct Food, Wuxi 214122, Jiangsu, Peoples R China.
   [Cao, Hong] Jiangnan Univ, Affiliated Hosp, Dept Endocrinol, Wuxi 214122, Jiangsu, Peoples R China.
   [Hua, Jiao] Jiangnan Univ, Affiliated Hosp, Hosp Infect Control Dept, Wuxi 214122, Jiangsu, Peoples R China.
   [Zhang, Feng] Chinese Soc Nutr Oncol, Beijing 100022, Peoples R China.
C3 Jiangnan University; Jiangnan University; Jiangnan University; Jiangnan
   University; Jiangnan University
RP Zhang, F (通讯作者)，Jiangnan Univ, Affiliated Hosp, Nutr Dept, Wuxi 214122, Jiangsu, Peoples R China.; Zhang, F (通讯作者)，Jiangnan Univ, Wuxi Sch Med, Wuxi 214122, Jiangsu, Peoples R China.; Zhang, F (通讯作者)，Jiangnan Univ, Affiliated Hosp, Clin Assessment Ctr Funct Food, Wuxi 214122, Jiangsu, Peoples R China.; Zhang, F (通讯作者)，Chinese Soc Nutr Oncol, Beijing 100022, Peoples R China.
EM fengzhang@jiangnan.edu.cn
OI Zhang, Feng/0000-0002-1401-9728
FU National Natural Science Foundation of China [1522044, 31671909,
   31772034, 32101033, 81870544, 81870594]; Natural Science Foundation of
   Jiangsu Province [BK20181132, BK20210060]; Scientific Research Project
   of Jiangsu Commission of Health [M2021055]; Jiangsu Scientific Research
   Project of Elderly Health [LK2021035]; Jiangsu Scientific Research
   Project of Women's and Children's Health [F201741]; Scientific Research
   Project of Wuxi Commission of Health [ZZ003]; Wuxi scientific and
   technological development project [N20192024, N20191001, N2020X007];
   Translational medicine Research Program of Wuxi Translational Medicine
   Center [2020ZHYB08]
FX Y.F. and H.C. contributed equally to this work. This work was supported
   by the National Natural Science Foundation of China (1522044, 31671909,
   31772034, 32101033, 81870544, and 81870594); the Natural Science
   Foundation of Jiangsu Province (BK20181132, BK20210060); Scientific
   Research Project of Jiangsu Commission of Health (M2021055); Jiangsu
   Scientific Research Project of Elderly Health (LK2021035); Jiangsu
   Scientific Research Project of Women's and Children's Health (F201741);
   Scientific Research Project of Wuxi Commission of Health (ZZ003); Wuxi
   scientific and technological development project (N20192024, N20191001
   and N2020X007). Translational medicine Research Program of Wuxi
   Translational Medicine Center (2020ZHYB08).
CR Allin KH, 2015, EUR J ENDOCRINOL, V172, pR167, DOI 10.1530/EJE-14-0874
   Almugadam BS, 2020, J DIABETES RES, V2020, DOI 10.1155/2020/7253978
   Amyot J, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0036200
   Nguyen AT, 2014, DIABETES, V63, P471, DOI 10.2337/db13-0903
   Anhe FF, 2017, MOL METAB, V6, P1563, DOI 10.1016/j.molmet.2017.10.003
   Asarat M, 2016, IMMUNOL INVEST, V45, P205, DOI 10.3109/08820139.2015.1122613
   Bai J, 2016, J ETHNOPHARMACOL, V194, P717, DOI 10.1016/j.jep.2016.10.043
   Bauer PV, 2018, CELL METAB, V27, P101, DOI 10.1016/j.cmet.2017.09.019
   Bouchi R, 2017, J DIABETES INVEST, V8, P783, DOI 10.1111/jdi.12636
   Brial F, 2018, CELL MOL LIFE SCI, V75, P3977, DOI 10.1007/s00018-018-2901-1
   Burton Jeffrey H, 2015, J Diabetes Sci Technol, V9, P808, DOI 10.1177/1932296815577425
   Espin JC, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/270418
   Catalkaya G, 2020, FOOD FRONTIERS, V1, P109, DOI 10.1002/fft2.25
   Chambers ES, 2015, P NUTR SOC, V74, P328, DOI 10.1017/S0029665114001657
   Chau CF, 2006, TRENDS FOOD SCI TECH, V17, P313, DOI 10.1016/j.tifs.2005.12.005
   Chen L., 2018, SHAANXI J TRADIT CHI, V39, P415
   Chen ML, 2016, MBIO, V7, DOI 10.1128/mBio.02210-15
   Chimerel C, 2014, CELL REP, V9, P1202, DOI 10.1016/j.celrep.2014.10.032
   Cohen LJ, 2017, NATURE, V549, P48, DOI 10.1038/nature23874
   Cronin P, 2021, NUTRIENTS, V13, DOI 10.3390/nu13051655
   Danic M, 2021, EUR J PHARM SCI, V158, DOI 10.1016/j.ejps.2020.105668
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   DeFronzo RA, 2009, DIABETES, V58, P773, DOI 10.2337/db09-9028
   Dewulf EM, 2013, GUT, V62, P1112, DOI 10.1136/gutjnl-2012-303304
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Gonzalez FJ, 2016, GASTROENTEROLOGY, V151, P845, DOI 10.1053/j.gastro.2016.08.057
   Goodrich JK, 2014, CELL, V159, P789, DOI 10.1016/j.cell.2014.09.053
   Grarup N, 2014, DIABETOLOGIA, V57, P1528, DOI 10.1007/s00125-014-3270-4
   Greenway F, 2014, BENEF MICROBES, V5, P29, DOI 10.3920/BM2012.0063
   Greer RL, 2016, NAT COMMUN, V7, DOI 10.1038/ncomms13329
   Gu YY, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-01682-2
   Hold GL, 2014, GUT, V63, P1838, DOI 10.1136/gutjnl-2014-307305
   IJssennagger N, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0043260
   Kaakoush NO, 2017, TRENDS MOL MED, V23, P293, DOI 10.1016/j.molmed.2017.02.008
   Kaji L, 2014, DIGESTION, V89, P31, DOI 10.1159/000356211
   Altun HK, 2021, PUBLIC HEALTH NUTR, V24, P861, DOI 10.1017/S1368980020005297
   Koh A, 2020, CELL METAB, V32, P643, DOI 10.1016/j.cmet.2020.07.012
   Laparra JM, 2010, PHARMACOL RES, V61, P219, DOI 10.1016/j.phrs.2009.11.001
   Lee DM, 2018, CARDIOVASC DIABETOL, V17, DOI 10.1186/s12933-018-0708-x
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Liao XY, 2019, EBIOMEDICINE, V44, P665, DOI 10.1016/j.ebiom.2019.03.057
   Lyu M, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.02146
   Nanjan MJ, 2018, BIOORG CHEM, V77, P548, DOI 10.1016/j.bioorg.2018.02.009
   Napolitano A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100778
   Neyrinck AM, 2013, BRIT J NUTR, V109, P802, DOI 10.1017/S0007114512002206
   Olivares M, 2018, DIABETOLOGIA, V61, P1838, DOI 10.1007/s00125-018-4647-6
   Perez-Jimenez J, 2010, J AGR FOOD CHEM, V58, P4959, DOI 10.1021/jf100128b
   Powell DR, 2013, J PHARMACOL EXP THER, V345, P250, DOI 10.1124/jpet.113.203364
   Qin JJ, 2010, NATURE, V464, P59, DOI 10.1038/nature08821
   Rosenstiel P, 2013, CURR OPIN GASTROEN, V29, P125, DOI 10.1097/MOG.0b013e32835da2c7
   Schugar RC, 2017, CELL REP, V19, P2451, DOI 10.1016/j.celrep.2017.05.077
   Sircana A, 2018, CURR DIABETES REP, V18, DOI 10.1007/s11892-018-1057-6
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Tomas J, 2016, P NATL ACAD SCI USA, V113, pE5934, DOI 10.1073/pnas.1612559113
   Tomas-Barberan FA, 2014, J AGR FOOD CHEM, V62, P6535, DOI 10.1021/jf5024615
   van Bommel EJM, 2020, DIABETES METAB, V46, P164, DOI 10.1016/j.diabet.2019.11.005
   Visconti A, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-12476-z
   Wan MLY, 2019, CRIT REV FOOD SCI, V59, P1927, DOI 10.1080/10408398.2018.1433629
   Wang HD, 2020, ACTA DIABETOL, V57, P455, DOI 10.1007/s00592-019-01436-0
   Wang ZN, 2014, EUR HEART J, V35, P904, DOI 10.1093/eurheartj/ehu002
   Wang ZY, 2021, CRIT REV FOOD SCI, DOI 10.1080/10408398.2021.2009436
   Weaver GA, 1997, J NUTR, V127, P717, DOI 10.1093/jn/127.5.717
   Xian YB, 2021, J FUNCT FOODS, V76, DOI 10.1016/j.jff.2020.104288
   Xinyao Jiao, 2019, Journal of Nutritional Biochemistry, V64, P88, DOI 10.1016/j.jnutbio.2018.07.008
   Xourgia E, 2019, FRONT BIOSCI-LANDMRK, V24, P688, DOI 10.2741/4743
   Xu J, 2015, ISME J, V9, P552, DOI 10.1038/ismej.2014.177
   Yang M, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.00635
   Yang WY, 2014, LANCET DIABETES ENDO, V2, P46, DOI 10.1016/S2213-8587(13)70021-4
   Yao ME, 2020, BMC CARDIOVASC DISOR, V20, DOI 10.1186/s12872-019-01310-5
   Zhang CH, 2019, J ETHNOPHARMACOL, V237, P202, DOI 10.1016/j.jep.2019.02.040
   Zhang F, 2020, MICROBIOL MOL BIOL R, V84, DOI 10.1128/MMBR.00072-19
   Zhang ML, 2014, P NATL ACAD SCI USA, V111, pE3708, DOI 10.1073/pnas.1406156111
   Zhang MC, 2019, BMJ OPEN DIAB RES CA, V7, DOI 10.1136/bmjdrc-2019-000717
   Zhang Q, 2018, PEERJ, V6, DOI 10.7717/peerj.4446
   Zhang Q, 2018, EXP BIOL MED, V243, P34, DOI 10.1177/1535370217743765
   Zhang Q, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0184735
   Zhang QQ, 2016, MEDICINA-LITHUANIA, V52, P28, DOI 10.1016/j.medici.2015.11.008
   Zhang XY, 2017, DIABETES THER, V8, P293, DOI 10.1007/s13300-017-0226-y
   Zhao LP, 2018, SCIENCE, V359, P1151, DOI 10.1126/science.aao5774
   Zhao LP, 2013, NAT REV MICROBIOL, V11, P639, DOI 10.1038/nrmicro3089
   Zheng Y, 2018, NAT REV ENDOCRINOL, V14, P88, DOI 10.1038/nrendo.2017.151
   Zimmermann M, 2019, NATURE, V570, P462, DOI 10.1038/s41586-019-1291-3
   Zimmermann M, 2019, SCIENCE, V363, P600, DOI 10.1126/science.aat9931
NR 83
TC 1
Z9 1
U1 4
U2 18
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD JUL
PY 2022
VL 66
IS 13
AR 2200106
DI 10.1002/mnfr.202200106
EA MAY 2022
PG 14
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 2Q1CE
UT WOS:000793621100001
PM 35481618
DA 2023-06-08
ER

PT J
AU Cui, HT
   Li, YT
   Wang, YM
   Jin, LL
   Yang, L
   Wang, L
   Liao, JB
   Wang, HS
   Peng, YF
   Zhang, ZY
   Wang, HW
   Liu, XG
AF Cui, Huantian
   Li, Yuting
   Wang, Yuming
   Jin, Lulu
   Yang, Lu
   Wang, Li
   Liao, Jiabao
   Wang, Haoshuo
   Peng, Yanfei
   Zhang, Zhaiyi
   Wang, Hongwu
   Liu, Xiangguo
TI Da-Chai-Hu Decoction Ameliorates High Fat Diet-Induced Nonalcoholic
   Fatty Liver Disease Through Remodeling the Gut Microbiota and Modulating
   the Serum Metabolism
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE nonalcoholic fatty liver disease; Da-Chai-Hu decoction; gut microbiota;
   untargeted metabolomics; correlation analysis
ID PHOSPHATIDYLETHANOLAMINE METABOLISM; PHOSPHATIDYLCHOLINE; HOMEOSTASIS;
   METFORMIN; HEALTH; ACID
AB The dysbiosis in gut microbiota could affect host metabolism and contribute to the development of nonalcoholic fatty liver disease (NAFLD). Da-Chai-Hu decoction (DCH) has demonstrated protective effects on NAFLD, however, the exact mechanisms remain unclear. In this study, we established a NAFLD rat model using a high fat diet (HFD) and provided treatment with DCH. The changes in gut microbiota post DCH treatment were then investigated using 16S rRNA sequencing. Additionally, serum untargeted metabolomics were performed to examine the metabolic regulations of DCH on NAFLD. Our results showed that DCH treatment improved the dyslipidemia, insulin resistance (IR) and ameliorated pathological changes in NAFLD model rats. 16S rRNA sequencing and untargeted metabolomics showed significant dysfunction in gut microbiota community and serum metabolites in NAFLD model rats. DCH treatment restored the dysbiosis of gut microbiota and improved the dysfunction in serum metabolism. Correlation analysis indicated that the modulatory effects of DCH on the arachidonic acid (AA), glycine/serine/threonine, and glycerophospholipid metabolic pathways were related to alterations in the abundance of Romboutsia, Bacteroides, Lactobacillus, Akkermansia, Lachnoclostridium and Enterobacteriaceae in the gut microflora. In conclusion, our study revealed the ameliorative effects of DCH on NAFLD and indicated that DCH's function on NAFLD may link to the improvement of the dysbiosis of gut microbiota and the modulation of the AA, glycerophospholipid, and glycine/serine/threonine metabolic pathways.
C1 [Cui, Huantian; Liu, Xiangguo] Shandong Univ, Sch Life Sci, Shandong Prov Key Lab Anim Cell & Dev Biol, Qingdao, Peoples R China.
   [Li, Yuting; Wang, Yuming; Jin, Lulu; Yang, Lu; Wang, Haoshuo; Peng, Yanfei; Zhang, Zhaiyi; Wang, Hongwu] Tianjin Univ Tradit Chinese Med, Tianjin, Peoples R China.
   [Li, Yuting] Tianjin Univ Tradit Chinese Med, Teaching Hosp 1, Tianjin, Peoples R China.
   [Wang, Li] Tianjin Second Peoples Hosp, Tianjin, Peoples R China.
   [Liao, Jiabao] Jiaxing Hosp Tradit Chinese Med, Jiaxing, Peoples R China.
C3 Shandong University; Tianjin University of Traditional Chinese Medicine;
   Tianjin University of Traditional Chinese Medicine
RP Liu, XG (通讯作者)，Shandong Univ, Sch Life Sci, Shandong Prov Key Lab Anim Cell & Dev Biol, Qingdao, Peoples R China.; Zhang, ZY; Wang, HW (通讯作者)，Tianjin Univ Tradit Chinese Med, Tianjin, Peoples R China.
EM 3461285155@qq.com; whw2009@tjutcm.edu.cn; xgliu0508@yahoo.com.cn
RI Liu, Xiangguo/G-1091-2010; Cui, Huantian/AAS-4283-2021; wang,
   hw/HZH-3227-2023
OI Liu, Xiangguo/0000-0002-1879-3817; Yang, Lu/0000-0002-1270-1838
FU National Science Foundation of China [81703828]; Natural Science
   Foundation of Tianjin [17JCYBJC42800]; Science and Technology Projects
   in Key Fields of Traditional Chinese Medicine of Tianjin Municipal
   Health Commission [2020006]; Public Welfare Research Projects in Jiaxing
   [SQ2018001355]
FX This work was supported by National Science Foundation of China
   (81703828), Natural Science Foundation of Tianjin (17JCYBJC42800),
   Science and Technology Projects in Key Fields of Traditional Chinese
   Medicine of Tianjin Municipal Health Commission (No. 2020006) and Public
   Welfare Research Projects in Jiaxing (SQ2018001355).
CR Amabebe E, 2020, BRIT J NUTR, V123, P1127, DOI 10.1017/S0007114520000380
   Bhardwaj Sidharth S, 2007, Clin Liver Dis, V11, P597, DOI 10.1016/j.cld.2007.06.010
   Bibb S., 2018, MEDIAT INFLAMM, V2018, DOI DOI 10.1155/2018/9321643
   Calzada E, 2016, INT REV CEL MOL BIO, V321, P29, DOI 10.1016/bs.ircmb.2015.10.001
   Cao M, 2020, TRADIT MED RES, V5, P261, DOI 10.12032/TMR20200520182
   Chen ZW, 2008, J ZHEJIANG UNIV-SC B, V9, P616, DOI 10.1631/jzus.B0720016
   Cui HT, 2020, FRONT PHARMACOL, V11, DOI 10.3389/fphar.2020.00858
   Cui HT, 2018, FRONT PHARMACOL, V9, DOI 10.3389/fphar.2018.00571
   Cummings BP, 2011, P NATL ACAD SCI USA, V108, P14670, DOI 10.1073/pnas.1107163108
   Derrien M, 2017, MICROB PATHOGENESIS, V106, P171, DOI 10.1016/j.micpath.2016.02.005
   El-Din Sayed H Seif, 2014, J Egypt Soc Parasitol, V44, P295
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Fan YH, 2014, MONGOL J TRADITIONAL, V33, P9, DOI DOI 10.16040/j.cnki.cn15-1101.2014.17.014
   Fang J, 2017, EVID-BASED COMPL ALT, V2017, DOI 10.1155/2017/2945803
   Gaggini M, 2018, HEPATOLOGY, V67, P145, DOI 10.1002/hep.29465
   Gong SQ, 2020, FRONT PHARMACOL, V11, DOI 10.3389/fphar.2020.00297
   Han XJ, 2000, ORG LETT, V2, P2543, DOI 10.1021/ol0062392
   Huang SZ, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-25658-4
   Iizuka A., 2013, American Journal of Plant Sciences, V4, P454
   Ismail NA, 2011, ARCH MED SCI, V7, P501, DOI 10.5114/aoms.2011.23418
   Kadooka Y, 2010, EUR J CLIN NUTR, V64, P636, DOI 10.1038/ejcn.2010.19
   Kasai C, 2015, BMC GASTROENTEROL, V15, DOI 10.1186/s12876-015-0330-2
   Khan RS, 2019, HEPATOLOGY, V70, P711, DOI 10.1002/hep.30429
   Kuda T, 2017, J FUNCT FOODS, V35, P605, DOI 10.1016/j.jff.2017.06.030
   Li F, 2018, SCI CHINA LIFE SCI, V61, P770, DOI 10.1007/s11427-017-9303-9
   Li JC, 2018, FRONT PHARMACOL, V9, DOI 10.3389/fphar.2018.01110
   Li Y, 2013, BIOMED REP, V1, P57, DOI 10.3892/br.2012.18
   Li YT, 2021, TRADIT MED RES, V6, DOI 10.12032/TMR20200201157
   Li ZY, 2006, CELL METAB, V3, P321, DOI 10.1016/j.cmet.2006.03.007
   Liang JQ, 2020, GUT, V69, P1248, DOI 10.1136/gutjnl-2019-318532
   Liang YJ, 2018, EVID-BASED COMPL ALT, V2018, DOI 10.1155/2018/9390786
   Liu J, 2018, PHARMACOL RES, V134, P40, DOI 10.1016/j.phrs.2018.05.012
   Loomba R, 2009, ALIMENT PHARM THER, V29, P172, DOI 10.1111/j.1365-2036.2008.03869.x
   Maciejewska D, 2015, PROSTAG OTH LIPID M, V121, P184, DOI 10.1016/j.prostaglandins.2015.09.003
   Mesens N, 2012, TOXICOL PATHOL, V40, P491, DOI 10.1177/0192623311432290
   Miyamoto J, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-11978-0
   Nazli A, 2004, AM J PATHOL, V164, P947, DOI 10.1016/S0002-9440(10)63182-3
   Piao SH, 2020, BIOMED PHARMACOTHER, V121, DOI 10.1016/j.biopha.2019.109421
   Porras D, 2019, MOL NUTR FOOD RES, V63, DOI 10.1002/mnfr.201800930
   Ritze Y, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0101702
   Scarpello JHB, 1998, DIABETIC MED, V15, P651, DOI 10.1002/(SICI)1096-9136(199808)15:8<651::AID-DIA628>3.0.CO;2-A
   Shin JH, 2018, EUR J NUTR, V57, P2081, DOI 10.1007/s00394-017-1481-4
   Sonnweber T, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19113285
   Su GY, 2019, CURR DRUG METAB, V20, P292, DOI 10.2174/1389200220666181231124439
   Tremaroli V, 2012, NATURE, V489, P242, DOI 10.1038/nature11552
   van der Veen JN, 2017, BBA-BIOMEMBRANES, V1859, P1558, DOI 10.1016/j.bbamem.2017.04.006
   VanderHeiden MG, 1997, CELL, V91, P627, DOI 10.1016/S0092-8674(00)80450-X
   Wu SS, 2018, MOLECULES, V23, DOI 10.3390/molecules23123213
   Wu X, 2020, PHARMACOL RES, V158, DOI 10.1016/j.phrs.2020.104937
   Xie XH, 2021, TRADIT MED RES, V6, DOI 10.12032/TMR20191014139
   Xu PF, 2017, J PINEAL RES, V62, DOI 10.1111/jpi.12399
   Yin XC, 2013, SYST APPL MICROBIOL, V36, P188, DOI 10.1016/j.syapm.2012.12.009
   Yoshie F, 2004, PHARMACOL RES, V50, P223, DOI 10.1016/j.phrs.2004.02.003
   Zhang ZM, 2020, INT J BIOL MACROMOL, V159, P461, DOI 10.1016/j.ijbiomac.2020.05.003
   Zheng L, 2014, ACM T KNOWL DISCOV D, V9, DOI 10.1145/2611380
NR 55
TC 27
Z9 28
U1 8
U2 54
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD NOV 27
PY 2020
VL 11
AR 584090
DI 10.3389/fphar.2020.584090
PG 17
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA PC8TY
UT WOS:000597273000001
PM 33328987
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Ye, JJ
   Wu, ZZ
   Zhao, YF
   Zhang, S
   Liu, WT
   Su, Y
AF Ye, Junjun
   Wu, Zezhen
   Zhao, Yifei
   Zhang, Shuo
   Liu, Weiting
   Su, Yu
TI Role of gut microbiota in the pathogenesis and treatment of diabetes
   mullites: Advanced research-based review
SO FRONTIERS IN MICROBIOLOGY
LA English
DT Review
DE gut microbiota; type 1 diabetes mullites; type 2 diabetes mullites; gut
   leakiness; gut microbiota metabolites; microbiological therapy
ID CHAIN FATTY-ACIDS; TOLL-LIKE RECEPTORS; INTESTINAL MICROBIOTA; FECAL
   MICROBIOTA; SODIUM-BUTYRATE; BILE-ACIDS; INSULIN SENSITIVITY; PEPTIDE-1
   SECRETION; PROBIOTIC BACTERIA; METFORMIN ALTERS
AB Gut microbiota plays an important role in the proper functioning of human organisms, while its dysbiosis is associated with disease in various body organs. Diabetes mellitus (DM) is a set of heterogeneous metabolic diseases characterized by hyperglycemia caused by direct or indirect insulin deficiency. There is growing evidence that gut microbiota dysbiosis is closely linked to the development of DM. Gut microbiota composition changes in type 1 diabetes mullites (T1DM) and type 2 diabetes mullites (T2DM) patients, which may cause gut leakiness and uncontrolled entry of antigens into the circulation system, triggering an immune response that damages the isle beta cells or metabolic disorders. This review summarizes gut microbiota composition in healthy individuals and compares it to diabetes mullites patients. The possible pathogenesis by which gut microbiota dysbiosis causes DM, particularly gut leakiness and changes in gut microbiota metabolites is also discussed. It also presents the process of microbial-based therapies of DM.
C1 [Ye, Junjun; Wu, Zezhen; Zhang, Shuo] Shantou Univ Med Coll, Longhu Hosp, Affiliated Hosp 1, Dept Endocrine & Metab Dis, Shantou, Peoples R China.
   [Ye, Junjun] Shantou Univ, Med Coll, Shantou, Peoples R China.
   [Wu, Zezhen; Zhang, Shuo] Shantou Univ, Affiliated Hosp 1, Med Coll, Shantou, Peoples R China.
   [Zhao, Yifei; Liu, Weiting] Anhui Univ Chinese Med, Sch Nursing, Hefei, Anhui, Peoples R China.
   [Su, Yu] Anhui Univ Chinese Med, Ctr Teaching Evaluat, Hefei, Anhui, Peoples R China.
   [Su, Yu] Anhui Univ Chinese Med, Fac Dev, Hefei, Anhui, Peoples R China.
C3 Shantou University; Shantou University; Shantou University; Anhui
   University of Chinese Medicine; Anhui University of Chinese Medicine;
   Anhui University of Chinese Medicine
RP Liu, WT (通讯作者)，Anhui Univ Chinese Med, Sch Nursing, Hefei, Anhui, Peoples R China.; Su, Y (通讯作者)，Anhui Univ Chinese Med, Ctr Teaching Evaluat, Hefei, Anhui, Peoples R China.; Su, Y (通讯作者)，Anhui Univ Chinese Med, Fac Dev, Hefei, Anhui, Peoples R China.
EM liuweiting1213@126.com; 138569776@qq.com
CR Aakko J, 2017, BENEF MICROBES, V8, P563, DOI 10.3920/BM2016.0185
   Ahmad TR, 2019, NAT REV ENDOCRINOL, V15, P701, DOI 10.1038/s41574-019-0266-7
   Albenberg LG, 2014, GASTROENTEROLOGY, V146, P1564, DOI 10.1053/j.gastro.2014.01.058
   Alkanani AK, 2015, DIABETES, V64, P3510, DOI 10.2337/db14-1847
   Allcock GH, 2001, CLIN EXP IMMUNOL, V123, P62, DOI 10.1046/j.1365-2249.2001.01370.x
   Allin KH, 2018, DIABETOLOGIA, V61, P810, DOI 10.1007/s00125-018-4550-1
   Amabebe E, 2020, BRIT J NUTR, V123, P1127, DOI 10.1017/S0007114520000380
   Arboleya S, 2016, FRONT MICROBIOL, V7, DOI 10.3389/fmicb.2016.01204
   Atkinson MA, 2014, LANCET, V383, P69, DOI 10.1016/S0140-6736(13)60591-7
   Bach JF, 2018, NAT REV IMMUNOL, V18, P105, DOI 10.1038/nri.2017.111
   Bachem A, 2019, IMMUNITY, V51, P285, DOI 10.1016/j.immuni.2019.06.002
   Bauer PV, 2018, CELL METAB, V27, P101, DOI 10.1016/j.cmet.2017.09.019
   Bibbo S, 2017, ANN MED, V49, P11, DOI 10.1080/07853890.2016.1222449
   Bjursell M, 2011, AM J PHYSIOL-ENDOC M, V300, pE211, DOI 10.1152/ajpendo.00229.2010
   Bonder MJ, 2016, NAT GENET, V48, P1407, DOI 10.1038/ng.3663
   Bouter KE, 2017, GASTROENTEROLOGY, V152, P1671, DOI 10.1053/j.gastro.2016.12.048
   Calcinaro F, 2005, DIABETOLOGIA, V48, P1565, DOI 10.1007/s00125-005-1831-2
   Canfora EE, 2015, NAT REV ENDOCRINOL, V11, P577, DOI 10.1038/nrendo.2015.128
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   Chambers ES, 2015, GUT, V64, P1744, DOI 10.1136/gutjnl-2014-307913
   Chen FW, 2022, FRONT MOL BIOSCI, V9, DOI 10.3389/fmolb.2022.879294
   Chen K, 2017, MOL NUTR FOOD RES, V61, DOI 10.1002/mnfr.201601006
   Cinek O, 2018, DIABETES RES CLIN PR, V144, P51, DOI 10.1016/j.diabres.2018.08.010
   Classification and Diagnosis of Diabetes, 2022, DIABETES CARE, V45, pS17, DOI [10.2337/dc22-S002, DOI 10.2337/DC22-S002]
   Cotillard A, 2013, NATURE, V500, P585, DOI 10.1038/nature12480
   Cummings NE, 2018, J PHYSIOL-LONDON, V596, P623, DOI 10.1113/JP275075
   Danaei G, 2011, LANCET, V378, P31, DOI 10.1016/S0140-6736(11)60679-X
   Dave M, 2012, TRANSL RES, V160, P246, DOI 10.1016/j.trsl.2012.05.003
   David LA, 2014, NATURE, V505, P559, DOI 10.1038/nature12820
   de Goffau MC, 2013, DIABETES, V62, P1238, DOI 10.2337/db12-0526
   de Groot P, 2021, GUT, V70, P92, DOI [10.1136/gutjnl-2020-322630, 10.1136/gutjnl-2020-323252]
   de Mello VD, 2017, SCI REP-UK, V7, DOI 10.1038/srep46337
   Devaraj S, 2009, DIABETOLOGIA, V52, P1665, DOI 10.1007/s00125-009-1394-8
   Di Tommaso N, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph182312836
   Durazzo M, 2019, J CLIN MED, V8, DOI 10.3390/jcm8111843
   Fan Y, 2021, NAT REV MICROBIOL, V19, P55, DOI 10.1038/s41579-020-0433-9
   Fang S, 2015, NAT MED, V21, P159, DOI 10.1038/nm.3760
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Ghosh SS, 2020, J ENDOCR SOC, V4, DOI 10.1210/jendso/bvz039
   Giesbertz P, 2016, CURR OPIN CLIN NUTR, V19, P48, DOI 10.1097/MCO.0000000000000235
   Gudi R, 2019, IMMUNOLOGY, V157, P70, DOI 10.1111/imm.13048
   Guigoz Y, 2008, CURR OPIN CLIN NUTR, V11, P13, DOI 10.1097/MCO.0b013e3282f2bfdf
   Gurung M, 2020, EBIOMEDICINE, V51, DOI 10.1016/j.ebiom.2019.11.051
   Hague A, 1996, P NUTR SOC, V55, P937, DOI 10.1079/PNS19960090
   Han H, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19040995
   Hanssen NMJ, 2021, CELL METAB, V33, P1098, DOI 10.1016/j.cmet.2021.05.005
   Hartstra AV, 2015, DIABETES CARE, V38, P159, DOI 10.2337/dc14-0769
   Hasani A, 2021, J MED MICROBIOL, V70, DOI 10.1099/jmm.0.001435
   Hill C, 2014, NAT REV GASTRO HEPAT, V11, P506, DOI 10.1038/nrgastro.2014.66
   Ho J, 2019, J CLIN ENDOCR METAB, V104, P4427, DOI 10.1210/jc.2019-00481
   Holodniy M, 2011, PLOS ONE, V6, DOI [10.1371/journal.pone.0014764, 10.1371/journal.pone.0025792]
   Hooper LV, 2002, ANNU REV NUTR, V22, P283, DOI 10.1146/annurev.nutr.22.011602.092259
   Hou KJ, 2022, SIGNAL TRANSDUCT TAR, V7, DOI 10.1038/s41392-022-00974-4
   Hou KJ, 2022, BOSNIAN J BASIC MED, V22, P315, DOI 10.17305/bjbms.2021.6323
   Hou KJ, 2017, BIOMED RES-INDIA, V28, P129
   Isolauri E, 2012, J PAEDIATR CHILD H, V48, P1, DOI 10.1111/j.1440-1754.2012.02489.x
   Jakaitis BM, 2014, CLIN PERINATOL, V41, P423, DOI 10.1016/j.clp.2014.02.011
   Jandhyala SM, 2015, WORLD J GASTROENTERO, V21, P8787, DOI 10.3748/wjg.v21.i29.8787
   Janssen AF, 2017, J PHYSIOL-LONDON, V595, P477, DOI 10.1113/JP272476
   Jia LL, 2017, FRONT IMMUNOL, V8, DOI 10.3389/fimmu.2017.01345
   Jin CJ, 2015, BRIT J NUTR, V114, P1745, DOI 10.1017/S0007114515003621
   Kahn SE, 2014, LANCET, V383, P1068, DOI 10.1016/S0140-6736(13)62154-6
   Kanazawa A, 2021, NUTRIENTS, V13, DOI 10.3390/nu13020558
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Katsuma S, 2005, BIOCHEM BIOPH RES CO, V329, P386, DOI 10.1016/j.bbrc.2005.01.139
   Kayama H, 2020, ANNU REV IMMUNOL, V38, P23, DOI 10.1146/annurev-immunol-070119-115104
   Khan MT, 2014, CELL METAB, V20, P753, DOI 10.1016/j.cmet.2014.07.006
   Kim MS, 2013, ENV MICROBIOL REP, V5, P765, DOI 10.1111/1758-2229.12079
   Kimura I, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms2852
   Kimura I, 2011, P NATL ACAD SCI USA, V108, P8030, DOI 10.1073/pnas.1016088108
   Knip M, 2017, CURR DIABETES REP, V17, DOI 10.1007/s11892-017-0933-9
   Koh A, 2018, CELL, V175, P947, DOI 10.1016/j.cell.2018.09.055
   Kootte RS, 2017, CELL METAB, V26, P611, DOI 10.1016/j.cmet.2017.09.008
   Kostic AD, 2015, CELL HOST MICROBE, V17, P260, DOI 10.1016/j.chom.2015.01.001
   Kristensen NB, 2016, GENOME MED, V8, DOI 10.1186/s13073-016-0300-5
   Kuhre RE, 2018, MOL METAB, V11, P84, DOI 10.1016/j.molmet.2018.03.007
   Landman C, 2016, REV MED INTERNE, V37, P418, DOI 10.1016/j.revmed.2015.12.012
   Larraufie P, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-017-18259-0
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Lau K, 2011, J IMMUNOL, V186, P3538, DOI 10.4049/jimmunol.1001864
   Lau LHS, 2018, ADV EXP MED BIOL, V1061, P111, DOI 10.1007/978-981-10-8684-7_9
   Lee Y, 2021, DIABETES RES CLIN PR, V178, DOI 10.1016/j.diabres.2021.108985
   Lehmann S, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0132304
   Leiva-Gea I, 2018, DIABETES CARE, V41, P2385, DOI 10.2337/dc18-0253
   Li JL, 2021, CRIT REV FOOD SCI, DOI 10.1080/10408398.2021.1981228
   Li J, 2013, PHARMACOL THERAPEUT, V138, P441, DOI 10.1016/j.pharmthera.2013.03.003
   Li WD, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-019-56561-1
   Lian K, 2015, DIABETES, V64, P49, DOI 10.2337/db14-0312
   Livanos AE, 2016, NAT MICROBIOL, V1, DOI [10.1038/NMICROBIOL.2016.140, 10.1038/nmicrobiol.2016.140]
   Lomax AR, 2009, CURR PHARM DESIGN, V15, P1428, DOI 10.2174/138161209788168155
   Mahendran Y, 2017, DIABETOLOGIA, V60, P873, DOI 10.1007/s00125-017-4222-6
   Marietta EV, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0078687
   Marino E, 2017, NAT IMMUNOL, V18, P552, DOI 10.1038/ni.3713
   Medzhitov R, 2001, NAT REV IMMUNOL, V1, P135, DOI 10.1038/35100529
   Medzhitov R, 2009, NAT REV IMMUNOL, V9, P692, DOI 10.1038/nri2634
   Meijer K, 2010, CURR OPIN CLIN NUTR, V13, P715, DOI 10.1097/MCO.0b013e32833eebe5
   Mokhtari P, 2021, GUT MICROBES, V13, DOI 10.1080/19490976.2021.1926841
   Mu QH, 2017, FRONT IMMUNOL, V8, DOI 10.3389/fimmu.2017.00598
   Murri M, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-46
   Natividad JMM, 2012, INFLAMM BOWEL DIS, V18, P1434, DOI 10.1002/ibd.22848
   Neuman V, 2019, DIABETOLOGIA, V62, P1291, DOI 10.1007/s00125-019-4869-2
   Ng SC, 2022, GUT, V71, P716, DOI 10.1136/gutjnl-2020-323617
   Ohland CL, 2010, AM J PHYSIOL-GASTR L, V298, pG807, DOI 10.1152/ajpgi.00243.2009
   Pascale A, 2018, ENDOCRINE, V61, P357, DOI 10.1007/s12020-018-1605-5
   Pathak P, 2018, HEPATOLOGY, V68, P1574, DOI 10.1002/hep.29857
   Pellegrini S, 2017, J CLIN ENDOCR METAB, V102, P1468, DOI 10.1210/jc.2016-3222
   Peng J, 2014, J AUTOIMMUN, V53, P85, DOI 10.1016/j.jaut.2014.03.005
   Peng LY, 2007, PEDIATR RES, V61, P37, DOI 10.1203/01.pdr.0000250014.92242.f3
   Peng LY, 2009, J NUTR, V139, P1619, DOI 10.3945/jn.109.104638
   Perino A, 2014, J CLIN INVEST, V124, P5424, DOI 10.1172/JCI76289
   Priyadarshini M, 2018, ENDOCRINOLOGY, V159, P2495, DOI 10.1210/en.2018-00296
   Proctor LM, 2019, NATURE, V569, P641, DOI 10.1038/s41586-019-1238-8
   Qi CJ, 2016, CHINESE MED J-PEKING, V129, P1298, DOI 10.4103/0366-6999.182841
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Qin JJ, 2010, NATURE, V464, P59, DOI 10.1038/nature08821
   Que YY, 2021, FRONT IMMUNOL, V12, DOI 10.3389/fimmu.2021.722206
   Rinott E, 2021, GASTROENTEROLOGY, V160, P158, DOI 10.1053/j.gastro.2020.08.041
   Roelofsen H, 2010, BENEF MICROBES, V1, P433, DOI 10.3920/BM2010.0028
   Rosenbauer J, 2008, DIABETES-METAB RES, V24, P211, DOI 10.1002/dmrr.791
   Ruiz-Canela M, 2018, DIABETOLOGIA, V61, P1560, DOI 10.1007/s00125-018-4611-5
   Saeedi P, 2019, DIABETES RES CLIN PR, V157, DOI 10.1016/j.diabres.2019.107843
   Saemann MD, 2000, FASEB J, V14, P2380
   Saha S, 2021, GASTROENTEROLOGY, V160, P1961, DOI 10.1053/j.gastro.2021.01.010
   Sahuri-Arisoylu M, 2016, INT J OBESITY, V40, P955, DOI 10.1038/ijo.2016.23
   Savilahti E, 2018, DIABETOLOGIA, V61, P2668, DOI 10.1007/s00125-018-4738-4
   Schroeder B, 2016, NAT MED, V22, P1079, DOI 10.1038/nm.4185
   Sedighi M, 2017, MICROB PATHOGENESIS, V111, P362, DOI 10.1016/j.micpath.2017.08.038
   Shan ZL, 2017, AM J CLIN NUTR, V106, P888, DOI 10.3945/ajcn.117.157107
   Shapiro H, 2018, J EXP MED, V215, P383, DOI 10.1084/jem.20171965
   Shi H, 2006, J CLIN INVEST, V116, P3015, DOI 10.1172/JCI28898
   Shreiner AB, 2015, CURR OPIN GASTROEN, V31, P69, DOI 10.1097/MOG.0000000000000139
   Smits MM, 2021, DIABETES METAB, V47, DOI 10.1016/j.diabet.2021.101223
   Sommer F, 2013, NAT REV MICROBIOL, V11, P227, DOI 10.1038/nrmicro2974
   Sorini C, 2019, P NATL ACAD SCI USA, V116, P15140, DOI 10.1073/pnas.1814558116
   Staudinger JL, 2001, P NATL ACAD SCI USA, V98, P3369, DOI 10.1073/pnas.051551698
   Stecher B, 2011, CURR OPIN MICROBIOL, V14, P82, DOI 10.1016/j.mib.2010.10.003
   Stoddart LA, 2008, PHARMACOL REV, V60, P405, DOI 10.1124/pr.108.00802
   Sturm A, 2005, INFECT IMMUN, V73, P1452, DOI 10.1128/IAI.73.3.1452-1465.2005
   Su LL, 2022, SCI REP-UK, V12, DOI 10.1038/s41598-022-05127-9
   Sudo N, 2002, CLIN EXP ALLERGY, V32, P1112, DOI 10.1046/j.1365-2222.2002.01430.x
   Sumida K, 2022, FRONT CELL INFECT MI, V12, DOI 10.3389/fcimb.2022.892232
   Sun J, 2015, IMMUNITY, V43, P304, DOI 10.1016/j.immuni.2015.07.013
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Tai NW, 2016, J EXP MED, V213, P2129, DOI 10.1084/jem.20160526
   Takewaki F, 2021, NUTRIENTS, V13, DOI 10.3390/nu13062107
   Thaiss CA, 2018, SCIENCE, V359, P1376, DOI 10.1126/science.aar3318
   Thomas C, 2009, CELL METAB, V10, P167, DOI 10.1016/j.cmet.2009.08.001
   Tian Y, 2018, J NUTR BIOCHEM, V54, P28, DOI 10.1016/j.jnutbio.2017.10.011
   Tlaskalova-Hogenova H, 2011, CELL MOL IMMUNOL, V8, P110, DOI 10.1038/cmi.2010.67
   Tolhurst G, 2012, DIABETES, V61, P364, DOI 10.2337/db11-1019
   Uusitalo U, 2016, JAMA PEDIATR, V170, P20, DOI 10.1001/jamapediatrics.2015.2757
   Vallianou NG, 2018, DIABETES RES CLIN PR, V146, P111, DOI 10.1016/j.diabres.2018.10.008
   van Nood E, 2013, NEW ENGL J MED, V368, P2145, DOI [10.1056/NEJMoa1205037, 10.1056/NEJMc1303919]
   Velloso LA, 2015, ENDOCR REV, V36, P245, DOI 10.1210/er.2014-1100
   Vindigni SM, 2017, GASTROENTEROL CLIN N, V46, P171, DOI 10.1016/j.gtc.2016.09.012
   Vrancken G, 2019, NAT REV MICROBIOL, V17, P754, DOI 10.1038/s41579-019-0264-8
   Vrieze A, 2012, GASTROENTEROLOGY, V143, P913, DOI 10.1053/j.gastro.2012.06.031
   Walker WA, 2017, PEDIATR RES, V82, P387, DOI 10.1038/pr.2017.111
   Wang HB, 2012, DIGEST DIS SCI, V57, P3126, DOI 10.1007/s10620-012-2259-4
   Wang H, 2020, FRONT CELL INFECT MI, V9, DOI 10.3389/fcimb.2019.00455
   Watanabe M, 2006, NATURE, V439, P484, DOI 10.1038/nature04330
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Xia T, 2017, ONCOTARGET, V8, P64878, DOI 10.18632/oncotarget.17612
   Xiong YM, 2004, P NATL ACAD SCI USA, V101, P1045, DOI 10.1073/pnas.2637002100
   Xu Q, 2022, FRONT IMMUNOL, V12, DOI 10.3389/fimmu.2021.746998
   Yatsunenko T, 2012, NATURE, V486, P222, DOI 10.1038/nature11053
   Zhang YQ, 2006, P NATL ACAD SCI USA, V103, P1006, DOI 10.1073/pnas.0506982103
   Zhao LJ, 2019, ENDOCRINE, V66, P526, DOI 10.1007/s12020-019-02103-8
   Zhao LP, 2018, SCIENCE, V359, P1151, DOI 10.1126/science.aao5774
   Zhou D, 2018, EXP MOL MED, V50, DOI 10.1038/s12276-018-0183-1
   Zhou D, 2017, WORLD J GASTROENTERO, V23, P60, DOI 10.3748/wjg.v23.i1.60
   Zhou H, 2021, ACTA DIABETOL, V58, P249, DOI 10.1007/s00592-020-01563-z
   Zhou Z, 2022, FRONT CELL INFECT MI, V12, DOI 10.3389/fcimb.2022.834485
   Zhu TT, 2020, CURR NUTR REP, V9, P83, DOI 10.1007/s13668-020-00307-3
NR 174
TC 6
Z9 6
U1 18
U2 26
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1664-302X
J9 FRONT MICROBIOL
JI Front. Microbiol.
PD OCT 19
PY 2022
VL 13
AR 1029890
DI 10.3389/fmicb.2022.1029890
PG 13
WC Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology
GA 5Y7OY
UT WOS:000879473200001
PM 36338058
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Zhang, XY
   Wang, HT
   Xie, CG
   Hu, ZP
   Zhang, Y
   Peng, SH
   He, YC
   Kang, J
   Gao, H
   Yuan, HP
   Liu, Y
   Fan, G
AF Zhang, Xiyu
   Wang, Heting
   Xie, Chunguang
   Hu, Zhipeng
   Zhang, Yuan
   Peng, Sihan
   He, Yuchi
   Kang, Jian
   Gao, Hong
   Yuan, Haipo
   Liu, Ya
   Fan, Gang
TI Shenqi compound ameliorates type-2 diabetes mellitus by modulating the
   gut microbiota and metabolites
SO JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL
   AND LIFE SCIENCES
LA English
DT Article
DE Type 2 diabetes mellitus; Shenqi compound; Glycemic variability;
   Intestinal mucosal barrier; Gut microbiota; Metabolites
ID OBESITY; METFORMIN
AB The gut microbiota (GM) and metabolites are important factors in mediating the development of type-2 diabetes mellitus (T2DM). An imbalance in the gut microbiota and metabolites can disrupt the function of the intestinal barrier, cause changes in the permeability of the intestinal mucosa and promote the immune inflammatory response, thereby aggravating the fluctuation of blood glucose level and promoting the occurrence and development of the chronic complications of DM. Manipulating the GM and metabolites is a promising therapeutic intervention and is being studied extensively. Shenqi compound (SQC) is a traditional Chinese medicine formulation, which has been widely used to improve T2DM. Studies have demonstrated that SQC can reduce glycemic variability, alleviate the inflammatory response, etc. However, its underlying mechanism remains unknown. Therefore, in this experiment, We administered SQC to Goto-Kakizaki (GK) rats and evaluated its effect on blood glucose homeostasis and the intestinal mucosal barrier. We identified the profiles of the GM and metabolites with the aid of 16S rDNA gene sequencing and non-target metabolomics analysis. It showed that SQC intervention could reduce glycemic variability, regulate serum levels of glucagon and insulin, and improve injury to the intestinal mucosal barrier of GK rats. In the gut, the ratio of bacteria of the phyla Bacteroidetes/Firmicutes could be improved after SQC intervention. SQC also regulated the relative abundance of Prevotellaceae, Butyricimonas, Bacteroides, Blautia, Roseburia, Lactobacillus, and Rothia. We found out that expression of 40 metabolites was significantly improved after SQC intervention. Further analyses of metabolic pathways indicated that the therapeutic effect of SQC might be related predominantly to its ability to improve gluconeogenesis/glycolysis, amino acid metabolism, lipid metabolism, citrate cycle, and butanoate metabolism. These results suggest that SQC may exert a beneficial role in T2DM by modulating the GM and metabolites in different pathways.
C1 [Zhang, Xiyu; Xie, Chunguang; Gao, Hong; Yuan, Haipo; Liu, Ya] Hosp Chengdu Univ Tradit Chinese Med, TCM Regulating Metab Dis Key Lab Sichuan Prov, Chengdu, Peoples R China.
   [Wang, Heting] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Dept Tradit Chinese Med, Chengdu, Peoples R China.
   [Hu, Zhipeng; Peng, Sihan; He, Yuchi] Chengdu Univ Tradit Chinese Med, Sch Clin Med, Chengdu, Peoples R China.
   [Zhang, Yuan] Army Med Univ, Affiliated Hosp 1, Chongqing, Peoples R China.
   [Kang, Jian] Hosp Chengdu Univ Tradit Chinese Med, Dept Anorectal, Chengdu, Peoples R China.
   [Fan, Gang] Chengdu Univ Tradit Chinese Med, Sch Ethn Med, Chengdu, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine; Sichuan Provincial
   People's Hospital; University of Electronic Science & Technology of
   China; Chengdu University of Traditional Chinese Medicine; Army Medical
   University; Chengdu University of Traditional Chinese Medicine; Chengdu
   University of Traditional Chinese Medicine
RP Liu, Y (通讯作者)，Hosp Chengdu Univ Tradit Chinese Med, TCM Regulating Metab Dis Key Lab Sichuan Prov, Chengdu, Peoples R China.; Fan, G (通讯作者)，Chengdu Univ Tradit Chinese Med, Sch Ethn Med, Chengdu, Peoples R China.
EM liuyaya918@163.com; fangang1111@163.com
RI Fan, Gang/AGG-2500-2022
FU National Natural Science Founda-tion of China [82104813]; General
   Program of China Postdoctoral Sci-ence Foundation [2020M673563XB];
   Chengdu University of Traditional Chinese Medicine Xinglin Scholars
   Scientific Research Fund [BSH2019024, Y2019091, Y2019120]
FX Funding This study was supported by the National Natural Science
   Founda-tion of China [82104813] , General Program of China Postdoctoral
   Sci-ence Foundation [2020M673563XB] , Chengdu University of Traditional
   Chinese Medicine Xinglin Scholars Scientific Research Fund [BSH2019024]
   , and Science and Technology Development Fund of Affiliated Hospital of
   Chengdu University of Traditional Chinese Medi-cine [Y2019091 and
   Y2019120] .
CR Arneth B, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20102467
   Backhed F, 2007, P NATL ACAD SCI USA, V104, P979, DOI 10.1073/pnas.0605374104
   Bardou P, 2014, BMC BIOINFORMATICS, V15, DOI 10.1186/1471-2105-15-293
   Barlow GM, 2015, NUTR CLIN PRACT, V30, P787, DOI 10.1177/0884533615609896
   Bell GI, 2001, NATURE, V414, P788, DOI 10.1038/414788a
   Bonini JA, 1997, BIOCHEM BIOPH RES CO, V234, P190, DOI 10.1006/bbrc.1997.6591
   Canfora EE, 2015, NAT REV ENDOCRINOL, V11, P577, DOI 10.1038/nrendo.2015.128
   Ceriello A, 2019, LANCET DIABETES ENDO, V7, P221, DOI 10.1016/S2213-8587(18)30136-0
   Chen LF, 2019, INT J MOL MED, V43, P1139, DOI 10.3892/ijmm.2019.4050
   Connor SC, 2010, MOL BIOSYST, V6, P909, DOI 10.1039/b914182k
   Fava F, 2013, INT J OBESITY, V37, P216, DOI 10.1038/ijo.2012.33
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Frontoni S, 2013, DIABETES RES CLIN PR, V102, P86, DOI 10.1016/j.diabres.2013.09.007
   Gao H, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0207683
   Guasch-Ferre M, 2016, DIABETES CARE, V39, P833, DOI 10.2337/dc15-2251
   Gurung M, 2020, EBIOMEDICINE, V51, DOI 10.1016/j.ebiom.2019.11.051
   Henschel AM, 2018, PLOS ONE, V13, DOI [10.1371/journal.pone.0190351, 10.1371/journal.pone.019035]
   Hu YY, 2020, ACTA DIABETOL, V57, P279, DOI 10.1007/s00592-019-01421-7
   Jandhyala SM, 2015, WORLD J GASTROENTERO, V21, P8787, DOI 10.3748/wjg.v21.i29.8787
   Kim BR, 2017, J MICROBIOL BIOTECHN, V27, P2089, DOI 10.4014/jmb.1709.09027
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Liu J, 2018, PHARMACOL RES, V134, P40, DOI 10.1016/j.phrs.2018.05.012
   Liu Y, 2019, ENDOCR METAB IMMUNE, V19, P622, DOI 10.2174/1871530319666190225113859
   Lyu M, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.02146
   Mathur R, 2015, EXPERT REV GASTROENT, V9, P1087, DOI 10.1586/17474124.2015.1051029
   McNabney SM, 2017, NUTRIENTS, V9, DOI 10.3390/nu9121348
   Mithieux G, 2018, NEUROENDOCRINOLOGY, V106, P352, DOI 10.1159/000484526
   Murugesan S, 2018, EUR J CLIN MICROBIOL, V37, P621, DOI 10.1007/s10096-017-3143-0
   Newman MA, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.00224
   Nyangale EP, 2012, J PROTEOME RES, V11, P5573, DOI 10.1021/pr300637d
   Park S, 2014, EUR J PHARMACOL, V735, P184, DOI 10.1016/j.ejphar.2014.04.024
   Pascale A, 2019, CURR OPIN PHARMACOL, V49, P1, DOI 10.1016/j.coph.2019.03.011
   Pedersen HK, 2016, NATURE, V535, P376, DOI 10.1038/nature18646
   Portha B, 2005, DIABETES-METAB RES, V21, P495, DOI 10.1002/dmrr.566
   Pryde SE, 2002, FEMS MICROBIOL LETT, V217, P133, DOI 10.1111/j.1574-6968.2002.tb11467.x
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Qin ZX, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19123984
   Remely M, 2014, GENE, V537, P85, DOI 10.1016/j.gene.2013.11.081
   Richardson JR, 2020, NEUROSCI LETT, V721, DOI 10.1016/j.neulet.2020.134825
   Rinninella E, 2019, NUTRIENTS, V11, DOI 10.3390/nu11102393
   Saeedi P, 2019, DIABETES RES CLIN PR, V157, DOI 10.1016/j.diabres.2019.107843
   Scott LJ, 2017, DRUGS, V77, P209, DOI 10.1007/s40265-016-0686-9
   Sedighi M, 2017, MICROB PATHOGENESIS, V111, P362, DOI 10.1016/j.micpath.2017.08.038
   Williams R, 2020, DIABETES RES CLIN PR, V162, DOI 10.1016/j.diabres.2020.108072
   Zhang MC, 2019, BMJ OPEN DIAB RES CA, V7, DOI 10.1136/bmjdrc-2019-000717
   Zhao X, 2016, J DIABETES RES, V2016, DOI 10.1155/2016/2794591
   Zhao XQ, 2020, BIOMED PHARMACOTHER, V121, DOI 10.1016/j.biopha.2019.109559
   Zhu BL, 2010, PROTEIN CELL, V1, P718, DOI 10.1007/s13238-010-0093-z
   Zhu YZ, 2017, MICROB BIOTECHNOL, V10, P480, DOI 10.1111/1751-7915.12451
NR 49
TC 5
Z9 5
U1 6
U2 27
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1570-0232
EI 1873-376X
J9 J CHROMATOGR B
JI J. Chromatogr. B
PD APR 1
PY 2022
VL 1194
AR 123189
DI 10.1016/j.jchromb.2022.123189
EA FEB 2022
PG 12
WC Biochemical Research Methods; Chemistry, Analytical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 0V2DO
UT WOS:000788154400004
PM 35219959
DA 2023-06-08
ER

PT J
AU Salamon, D
   Sroka-Oleksiak, A
   Kapusta, P
   Szopa, M
   Mrozinska, S
   Ludwig-Slomczynska, AH
   Wolkow, PP
   Bulanda, M
   Klupa, T
   Malecki, MT
   Gosiewski, T
AF Salamon, Dominika
   Sroka-Oleksiak, Agnieszka
   Kapusta, Przemyslaw
   Szopa, Magdalena
   Mrozinska, Sandra
   Ludwig-Slomczynska, Agnieszka H.
   Wolkow, Pawel P.
   Bulanda, Malgorzata
   Klupa, Tomasz
   Malecki, Maciej T.
   Gosiewski, Tomasz
TI Characteristics of gut microbiota in adult patients with type 1 and type
   2 diabetes based on next-generation sequencing of the 16S rRNA gene
   fragment
SO POLISH ARCHIVES OF INTERNAL MEDICINE-POLSKIE ARCHIWUM MEDYCYNY
   WEWNETRZNEJ
LA English
DT Article
DE diabetes; gut microbiota; sequencing
ID INTESTINAL MICROBIOTA; PROBIOTICS; OBESITY; METFORMIN; BACTERIAL
AB INTRODUCTION Scientific data indicate a possible influence of gut microbiota on the development of type 1 and type 2 diabetes mellitus (T1DM and T2DM, respectively). Sequence analysis of 16S ribosomal RNA identified several hundred bacterial species of the intestinal ecosystem, most of which cannot be cultured.
   OBJECTIVES We aimed to evaluate gut microbiota composition in adult patients with T1DM and T2DM and establish a link between microbiological test results and patients' clinical data.
   PATIENTS AND METHODS We examined DNA isolated from fecal samples in 3 groups: healthy volunteers (n = 23), patients with T1DM (n = 22), and patients with T2DM (n = 23). Next-generation sequencing was performed on the MiSeq platform.
   RESULTS At the phylum level, the Firmicutes bacteria prevailed (>77%) in all groups. At the taxonomic levels L2 (phylum) and L6 (genus), significant differences were demonstrated in bacterial profiles, particularly in the T2DM group. A negative correlation was observed between several genera of bacteria and the percentage of glycated hemoglobin A(1c) in the T2DM group, while a positive correlation was revealed between bacteria belonging to the genus Bifidobacterium and high-density lipoprotein cholesterol levels in both T1DM and T2DM groups.
   CONCLUSIONS Our results provide grounds for conducting research in the field of gut microbiota in order to develop individualized therapy for patients with diabetes based on modifying the microbiota composition, as a new method for controlling glycemia. Next-generation sequencing allows a rapid identification of the DNA of all bacteria present in the sample and their taxonomic classification.
C1 [Salamon, Dominika; Sroka-Oleksiak, Agnieszka; Gosiewski, Tomasz] Jagiellonian Univ, Fac Med, Dept Microbiol, Div Mol Med Microbiol,Med Coll, Krakow, Poland.
   [Sroka-Oleksiak, Agnieszka] Jagiellonian Univ, Fac Med, Dept Microbiol, Div Mycol,Med Coll, Krakow, Poland.
   [Kapusta, Przemyslaw; Ludwig-Slomczynska, Agnieszka H.; Wolkow, Pawel P.] Jagiellonian Univ, Fac Med, Ctr Med Genom OMICRON, Med Coll, Krakow, Poland.
   [Szopa, Magdalena; Mrozinska, Sandra; Klupa, Tomasz; Malecki, Maciej T.] Jagiellonian Univ, Fac Med, Dept Metab Dis, Med Coll, Krakow, Poland.
   [Szopa, Magdalena; Mrozinska, Sandra; Klupa, Tomasz; Malecki, Maciej T.] Univ Hosp, Dept Metab Dis, Krakow, Poland.
   [Bulanda, Malgorzata] Jagiellonian Univ, Fac Med, Dept Microbiol, Div Epidemiol Infect,Med Coll, Krakow, Poland.
C3 Jagiellonian University; Collegium Medicum Jagiellonian University;
   Jagiellonian University; Collegium Medicum Jagiellonian University;
   Jagiellonian University; Collegium Medicum Jagiellonian University;
   Jagiellonian University; Collegium Medicum Jagiellonian University;
   Jagiellonian University; Collegium Medicum Jagiellonian University;
   Jagiellonian University; Collegium Medicum Jagiellonian University
RP Gosiewski, T (通讯作者)，Uniwersytet Jagiellonski, Coll Med, Zaklad Mol Mikrobiol Med, Katedra Mikrobiol,Wydzial Lekarski, Ul Czysta 18, PL-31121 Krakow, Poland.
EM tomasz.gosiewski@uj.edu.pl
RI Klupa, Tomasz/V-9559-2019; Sroka-Oleksiak, Agnieszka/GRE-8475-2022;
   Gosiewski, Tomasz/GSN-5166-2022; Salamon, Dominika/ADX-9625-2022;
   Wolkow, Pawel/AAI-4222-2021; Gosiewski, Tomasz/U-3349-2018; Gosiewski,
   Tomasz/ABI-5869-2020; Sroka-Oleksiak, Agnieszka/GRS-2686-2022; Szopa,
   Magdalena/AAI-7193-2020
OI Sroka-Oleksiak, Agnieszka/0000-0003-4998-279X; Gosiewski,
   Tomasz/0000-0003-4725-5943; Wolkow, Pawel/0000-0002-9322-5545;
   Gosiewski, Tomasz/0000-0003-4725-5943; Gosiewski,
   Tomasz/0000-0003-4725-5943; Ludwig-Slomczynska, Agnieszka
   H./0000-0002-0548-4767; Kapusta, Przemyslaw/0000-0003-4467-1175
FU National Science Center in Poland: "SONATA" [DEC-2011/03/D/NZ5/00551]
FX We would like to thank participants in this study. The study was carried
   out as part of the project entitled "Evaluation of the microbiota in the
   gastrointestinal tract of the patients with diabetes type 1 and 2 and
   with morbid or pathological obesity undergoing laparoscopic sleeve
   gastrectomy", supported by the National Science Center in Poland:
   "SONATA" (No. DEC-2011/03/D/NZ5/00551; to TG).
CR An HM, 2011, LIPIDS HEALTH DIS, V10, DOI 10.1186/1476-511X-10-116
   Biagi E, 2012, AGE, V34, P247, DOI 10.1007/s11357-011-9217-5
   Blandino G, 2016, DIABETES METAB, V42, P303, DOI 10.1016/j.diabet.2016.04.004
   Brugman S, 2006, DIABETOLOGIA, V49, P2105, DOI 10.1007/s00125-006-0334-0
   Bry L, 1996, SCIENCE, V273, P1380, DOI 10.1126/science.273.5280.1380
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   Cani PD, 2015, CURR OPIN BIOTECH, V32, P21, DOI 10.1016/j.copbio.2014.10.006
   Egshatyan L, 2016, ENDOCR CONNECT, V5, P1, DOI 10.1530/EC-15-0094
   Mejia-Leon ME, 2014, SCI REP-UK, V4, DOI 10.1038/srep03814
   Faith JJ, 2013, SCIENCE, V341
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Fraher MH, 2012, NAT REV GASTRO HEPAT, V9, P312, DOI 10.1038/nrgastro.2012.44
   Fyderek K, 2009, WORLD J GASTROENTERO, V15, P5287, DOI 10.3748/wjg.15.5287
   Gosiewski T, 2014, CURR MICROBIOL, V68, P149, DOI 10.1007/s00284-013-0451-1
   Gulden E, 2015, CLIN IMMUNOL, V159, P143, DOI 10.1016/j.clim.2015.05.013
   Hu CY, 2015, PHARMACOL RES, V98, P9, DOI 10.1016/j.phrs.2015.02.006
   Ichim TE, 2016, J TRANSL MED, V14, DOI 10.1186/s12967-016-0945-2
   Inter- American Commission on Human Rights, 2015, IDF DIABETES ATLAS, P62
   Ji BoYang, 2015, Advances in Genomics and Genetics, V5, P77
   Kasinska MA, 2015, POL ARCH MED WEWN, V125, P803, DOI 10.20452/pamw.3156
   Kostic AD, 2015, CELL HOST MICROBE, V17, P260, DOI 10.1016/j.chom.2015.01.001
   Lambeth Stacey M, 2015, J Diabetes Obes, V2, P1
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Londahl M., 2017, CLIN DIABETOL, V6, P1, DOI DOI 10.5603/DK.2017.0001
   Mariat D, 2009, BMC MICROBIOL, V9, DOI 10.1186/1471-2180-9-123
   Moayyedi P, 2017, POL ARCH INTERN MED, V127, P135, DOI 10.20452/pamw.3961
   Mrozinska S, 2016, J DIABETES RES, V2016, DOI 10.1155/2016/3876764
   Peterson J, 2009, GENOME RES, V19, P2317, DOI 10.1101/gr.096651.109
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Qin JJ, 2010, NATURE, V464, P59, DOI 10.1038/nature08821
   Remely M, 2013, J DIABETES METAB, V4, DOI 10.4172/2155-6156.1000253
   Serino M, 2009, DIABETES METAB, V35, P262, DOI 10.1016/j.diabet.2009.03.003
   Shen J, 2013, MOL ASPECTS MED, V34, P39, DOI 10.1016/j.mam.2012.11.001
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Stewart CJ, 2017, DIABETIC MED, V34, P127, DOI 10.1111/dme.13140
   Strober W, 2010, NAT MED, V16, P1195, DOI 10.1038/nm1110-1195
   Tilg H, 2014, GUT, V63, P1513, DOI 10.1136/gutjnl-2014-306928
   Turnbaugh PJ, 2007, NATURE, V449, P804, DOI 10.1038/nature06244
   Turnbaugh PJ, 2009, NATURE, V457, P480, DOI 10.1038/nature07540
   Vanderhoof JA, 2008, J PEDIATR GASTR NUTR, V47, pS38, DOI 10.1097/01.mpg.0000338810.74933.c1
   Wen L, 2008, NATURE, V455, P1109, DOI 10.1038/nature07336
   Yamaguchi Y, 2016, DIGESTION, V94, P66, DOI 10.1159/000447690
   Yassour M, 2016, GENOME MED, V8, DOI 10.1186/s13073-016-0271-6
NR 44
TC 63
Z9 68
U1 2
U2 31
PU MEDYCYNA PRAKTYCZNA SP K SP ZOO
PI KRAKOW
PA REJTANA 2, KRAKOW, 30-510    AP, POLAND
SN 0032-3772
EI 1897-9483
J9 POL ARCH INTERN MED
JI Pol. Intern. Med.
PY 2018
VL 128
IS 6
BP 336
EP 343
DI 10.20452/pamw.4246
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA GM8PZ
UT WOS:000438496000003
PM 29657308
OA Green Published, Bronze
DA 2023-06-08
ER

PT J
AU Zhang, LL
   Chu, JJ
   Hao, WH
   Zhang, JJ
   Li, HB
   Yang, CJ
   Yang, JH
   Chen, XH
   Wang, HG
AF Zhang, Lili
   Chu, Jinjin
   Hao, Wenhao
   Zhang, Jiaojiao
   Li, Haibo
   Yang, Chunjuan
   Yang, Jinghan
   Chen, Xiaohua
   Wang, Honggang
TI Gut Microbiota and Type 2 Diabetes Mellitus: Association, Mechanism, and
   Translational Applications
SO MEDIATORS OF INFLAMMATION
LA English
DT Review
ID CHAIN FATTY-ACIDS; GLUCAGON-LIKE PEPTIDE-1; INTESTINAL MICROBIOTA;
   AKKERMANSIA-MUCINIPHILA; DIETARY FIBER; AMINO-ACIDS; INFLAMMATORY
   CYTOKINES; INSULIN SENSITIVITY; GLUCOSE-METABOLISM; METFORMIN ALTERS
AB Gut microbiota has attracted widespread attention due to its crucial role in disease pathophysiology, including type 2 diabetes mellitus (T2DM). Metabolites and bacterial components of gut microbiota affect the initiation and progression of T2DM by regulating inflammation, immunity, and metabolism. Short-chain fatty acids, secondary bile acid, imidazole propionate, branched-chain amino acids, and lipopolysaccharide are the main molecules related to T2DM. Many studies have investigated the role of gut microbiota in T2DM, particularly those butyrate-producing bacteria. Increasing evidence has demonstrated that fecal microbiota transplantation and probiotic capsules are useful strategies in preventing diabetes. In this review, we aim to elucidate the complex association between gut microbiota and T2DM inflammation, metabolism, and immune disorders, the underlying mechanisms, and translational applications of gut microbiota. This review will provide novel insight into developing individualized therapy for T2DM patients based on gut microbiota immunometabolism.
C1 [Zhang, Lili; Chu, Jinjin; Zhang, Jiaojiao; Li, Haibo] Weifang Peoples Hosp, Cent Lab, Weifang 261000, Peoples R China.
   [Hao, Wenhao] Weifang Peoples Hosp, Dept Sci Res Management, Weifang 261000, Peoples R China.
   [Yang, Chunjuan; Yang, Jinghan] Weifang Med Univ, Affiliated Hosp 1, Cent Lab, Weifang 261000, Peoples R China.
   [Chen, Xiaohua] Weifang Peoples Hosp, Dept Nucl Med, Weifang 261000, Peoples R China.
   [Wang, Honggang] Weifang Peoples Hosp, Clin Lab, Weifang 261000, Peoples R China.
C3 Weifang Medical University
RP Chen, XH (通讯作者)，Weifang Peoples Hosp, Dept Nucl Med, Weifang 261000, Peoples R China.; Wang, HG (通讯作者)，Weifang Peoples Hosp, Clin Lab, Weifang 261000, Peoples R China.
EM 2760370581@qq.com; wf661188@163.com
OI Wang, Honggang/0000-0002-1170-6805
FU Shandong Natural Science Foundation [ZR2020KC001]; Shandong Science and
   Technology Development Program [2016WS0657]; Science and Technology
   Development Program of Weifang [2020TX084]
FX We acknowledge funds from Shandong Natural Science Foundation
   (ZR2020KC001), Shandong Science and Technology Development Program
   (2016WS0657), and the Science and Technology Development Program of
   Weifang (2020TX084). We thank very much Professor Lili Lu for her great
   help for revising the manuscript.
CR Agarwal P, 2014, PHARM RES-DORDR, V31, P3404, DOI 10.1007/s11095-014-1430-3
   Allin KH, 2018, DIABETOLOGIA, V61, P810, DOI 10.1007/s00125-018-4550-1
   Ansaldo E, 2019, SCIENCE, V364, P1179, DOI 10.1126/science.aaw7479
   Antushevich H, 2020, CLIN CHIM ACTA, V503, P90, DOI 10.1016/j.cca.2019.12.010
   Ardeshirlarijani E, 2019, DARU, V27, P827, DOI 10.1007/s40199-019-00302-2
   Arpaia N, 2013, NATURE, V504, P451, DOI 10.1038/nature12726
   Asghari G, 2018, J DIABETES, V10, P357, DOI 10.1111/1753-0407.12639
   Backhed F, 2004, P NATL ACAD SCI USA, V101, P15718, DOI 10.1073/pnas.0407076101
   Bauer PV, 2018, CELL METAB, V27, P101, DOI 10.1016/j.cmet.2017.09.019
   Burger-van Paassen N, 2009, BIOCHEM J, V420, P211, DOI 10.1042/BJ20082222
   Byndloss MX, 2017, SCIENCE, V357, P570, DOI 10.1126/science.aam9949
   Candela M, 2016, BRIT J NUTR, V116, P80, DOI 10.1017/S0007114516001045
   Cani PD, 2012, GUT MICROBES, V3, P279, DOI 10.4161/gmic.19625
   Chen TL, 2016, SCI REP-UK, V6, DOI 10.1038/srep20594
   Cheng D, 2021, J APPL MICROBIOL, V130, P1813, DOI 10.1111/jam.14911
   Clarke SF, 2014, GUT, V63, P1913, DOI 10.1136/gutjnl-2013-306541
   Creely SJ, 2007, AM J PHYSIOL-ENDOC M, V292, pE740, DOI 10.1152/ajpendo.00302.2006
   Cui BT, 2015, J GASTROEN HEPATOL, V30, P51, DOI 10.1111/jgh.12727
   CUMMINGS JH, 1987, GUT, V28, P1221, DOI 10.1136/gut.28.10.1221
   Dao MC, 2016, GUT, V65, P426, DOI 10.1136/gutjnl-2014-308778
   de Groot P, 2020, GUT, V69, P502, DOI 10.1136/gutjnl-2019-318320
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   De Vadder F, 2014, CELL, V156, P84, DOI 10.1016/j.cell.2013.12.016
   Depommier C, 2019, NAT MED, V25, P1096, DOI 10.1038/s41591-019-0495-2
   Desai MS, 2016, CELL, V167, P1339, DOI 10.1016/j.cell.2016.10.043
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Fallucca F, 2014, DIABETES-METAB RES, V30, P48, DOI 10.1002/dmrr.2518
   Fiorucci S, 2015, TRENDS MOL MED, V21, P702, DOI 10.1016/j.molmed.2015.09.001
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Furusawa Y, 2013, NATURE, V504, P446, DOI 10.1038/nature12721
   Gala TD, 2018, DIABETES-METAB RES, V34, DOI 10.1002/dmrr.3063
   Gomes JMG, 2017, METABOLISM, V68, P133, DOI 10.1016/j.metabol.2016.12.009
   Giesbertz P, 2016, CURR OPIN CLIN NUTR, V19, P48, DOI 10.1097/MCO.0000000000000235
   Gough E, 2011, CLIN INFECT DIS, V53, P994, DOI 10.1093/cid/cir632
   Gu YY, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-01682-2
   Gurung M, 2020, EBIOMEDICINE, V51, DOI 10.1016/j.ebiom.2019.11.051
   Hamasaki H, 2018, WORLD J DIABETES, V9, P138, DOI 10.4239/wjd.v9.i8.138
   Hansen CHF, 2012, DIABETOLOGIA, V55, P2285, DOI 10.1007/s00125-012-2564-7
   Horton F, 2014, DIABETIC MED, V31, P559, DOI 10.1111/dme.12360
   Hu Y, 2020, BMJ-BRIT MED J, V370, DOI 10.1136/bmj.m2206
   Jandhyala SM, 2015, WORLD J GASTROENTERO, V21, P8787, DOI 10.3748/wjg.v21.i29.8787
   Jayashree B, 2014, MOL CELL BIOCHEM, V388, P203, DOI 10.1007/s11010-013-1911-4
   Jenkins DW, 2017, J FOOT ANKLE SURG, V56, P968, DOI 10.1053/j.jfas.2017.06.019
   Kaji L, 2014, DIGESTION, V89, P31, DOI 10.1159/000356211
   Kakiyama G, 2013, J HEPATOL, V58, P949, DOI 10.1016/j.jhep.2013.01.003
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Katsanos CS, 2006, AM J PHYSIOL-ENDOC M, V291, pE381, DOI 10.1152/ajpendo.00488.2005
   Kawaguchi T, 2011, HEPATOLOGY, V54, P1063, DOI 10.1002/hep.24412
   Kerry RG, 2018, J FOOD DRUG ANAL, V26, P927, DOI 10.1016/j.jfda.2018.01.002
   Knowler WC, 2002, NEW ENGL J MED, V346, P393, DOI 10.1056/NEJMoa012512
   Koh A, 2020, CELL METAB, V32, P643, DOI 10.1016/j.cmet.2020.07.012
   Koh A, 2018, CELL, V175, P947, DOI 10.1016/j.cell.2018.09.055
   Koh A, 2016, CELL, V165, P1332, DOI 10.1016/j.cell.2016.05.041
   Kootte RS, 2017, CELL METAB, V26, P611, DOI 10.1016/j.cmet.2017.09.008
   Kovatcheva-Datchary P, 2015, CELL METAB, V22, P971, DOI 10.1016/j.cmet.2015.10.001
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Li WZ, 2020, WORLD J DIABETES, V11, P293, DOI 10.4239/wjd.v11.i7.293
   Lin HV, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0035240
   Liu Y, 2020, CELL METAB, V31, P77, DOI 10.1016/j.cmet.2019.11.001
   Mannucci E, 2004, DIABETES NUTR METAB, V17, P336
   Martin AM, 2019, P NATL ACAD SCI USA, V116, P19802, DOI 10.1073/pnas.1909311116
   McCreight LJ, 2016, DIABETOLOGIA, V59, P426, DOI 10.1007/s00125-015-3844-9
   McRae MP, 2018, J CHIROPR MED, V17, P44, DOI 10.1016/j.jcm.2017.11.002
   Molinaro A, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-19589-w
   Motiani KK, 2020, MED SCI SPORT EXER, V52, P94, DOI 10.1249/MSS.0000000000002112
   Newgard CB, 2009, CELL METAB, V9, P311, DOI 10.1016/j.cmet.2009.02.002
   Nie QX, 2019, CRIT REV FOOD SCI, V59, P848, DOI 10.1080/10408398.2018.1536646
   O'Hara AM, 2006, EMBO REP, V7, P688, DOI 10.1038/sj.embor.7400731
   Pedersen HK, 2016, NATURE, V535, P376, DOI 10.1038/nature18646
   Plovier H, 2017, NAT MED, V23, P107, DOI 10.1038/nm.4236
   Psichas A, 2015, INT J OBESITY, V39, P424, DOI 10.1038/ijo.2014.153
   Pussinen PJ, 2011, DIABETES CARE, V34, P392, DOI 10.2337/dc10-1676
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Rodes L, 2013, J MICROBIOL BIOTECHN, V23, P518, DOI 10.4014/jmb.1205.05018
   Saeedi P, 2019, DIABETES RES CLIN PR, V157, DOI 10.1016/j.diabres.2019.107843
   Salamon D, 2018, POL ARCH INTERN MED, V128, P336, DOI 10.20452/pamw.4246
   Sanna S, 2019, NAT GENET, V51, P600, DOI 10.1038/s41588-019-0350-x
   Sayin SI, 2013, CELL METAB, V17, P225, DOI 10.1016/j.cmet.2013.01.003
   Schloissnig S, 2013, NATURE, V493, P45, DOI 10.1038/nature11711
   Shapiro H, 2018, J EXP MED, V215, P383, DOI 10.1084/jem.20171965
   Sharma S, 2019, J NUTR BIOCHEM, V63, P101, DOI 10.1016/j.jnutbio.2018.10.003
   Singh VP, 2013, J PAK MED ASSOC, V63, P253
   Smith PM, 2013, SCIENCE, V341, P569, DOI 10.1126/science.1241165
   Su BL, 2015, J DIABETES, V7, P729, DOI 10.1111/1753-0407.12232
   Sun J, 2016, BRIT J NUTR, V115, P1167, DOI 10.1017/S0007114516000076
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Sun ZK, 2020, CRIT REV FOOD SCI, V60, P670, DOI 10.1080/10408398.2018.1547268
   Suzuki T, 2008, BRIT J NUTR, V100, P297, DOI 10.1017/S0007114508888733
   Swann JR, 2011, P NATL ACAD SCI USA, V108, P4523, DOI 10.1073/pnas.1006734107
   Takahashi D, 2020, EBIOMEDICINE, V58, DOI 10.1016/j.ebiom.2020.102913
   Tao YW, 2020, J TRANSL MED, V18, DOI 10.1186/s12967-020-02213-2
   Teich T, 2019, DIABETES TECHNOL THE, V21, pS112, DOI 10.1089/dia.2019.2509
   Tian JX, 2019, DIABETES OBES METAB, V21, P1801, DOI 10.1111/dom.13760
   Tolhurst G, 2012, DIABETES, V61, P364, DOI 10.2337/db11-1019
   Tong XL, 2018, MBIO, V9, DOI 10.1128/mBio.02392-17
   Trabelsi MS, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms8629
   Trompette A, 2014, NAT MED, V20, P159, DOI 10.1038/nm.3444
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Valdes AM, 2018, BMJ-BRIT MED J, V361, DOI 10.1136/bmj.k2179
   Velazquez-Lopez L, 2016, J DIABETES RES, V2016, DOI 10.1155/2016/2980406
   Vrieze A, 2012, GASTROENTEROLOGY, V143, P913, DOI 10.1053/j.gastro.2012.06.031
   Wang HB, 2012, DIGEST DIS SCI, V57, P3126, DOI 10.1007/s10620-012-2259-4
   Wang JK, 2020, BIOMED PHARMACOTHER, V121, DOI 10.1016/j.biopha.2019.109565
   Wang TJ, 2011, NAT MED, V17, P448, DOI 10.1038/nm.2307
   Wu H, 2020, CELL METAB, V32, P379, DOI 10.1016/j.cmet.2020.06.011
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Xu J, 2015, ISME J, V9, P552, DOI 10.1038/ismej.2014.177
   Xu JH, 2020, J DIABETES, V12, P224, DOI 10.1111/1753-0407.12986
   Zhai QX, 2019, CRIT REV FOOD SCI, V59, P3227, DOI 10.1080/10408398.2018.1517725
   Zhang XY, 2017, DIABETES THER, V8, P293, DOI 10.1007/s13300-017-0226-y
   Zhang YF, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-18414-8
   Zhao LP, 2018, SCIENCE, V359, P1151, DOI 10.1126/science.aao5774
   Zhao SQ, 2017, J MOL ENDOCRINOL, V58, P1, DOI 10.1530/JME-16-0054
   Zheng XJ, 2021, CELL METAB, V33, P791, DOI 10.1016/j.cmet.2020.11.017
   Zheng Y, 2016, INT J EPIDEMIOL, V45, P1482, DOI 10.1093/ije/dyw143
NR 115
TC 22
Z9 24
U1 6
U2 46
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 0962-9351
EI 1466-1861
J9 MEDIAT INFLAMM
JI Mediat. Inflamm.
PD AUG 17
PY 2021
VL 2021
AR 5110276
DI 10.1155/2021/5110276
PG 12
WC Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Immunology
GA UJ2AP
UT WOS:000691095200001
PM 34447287
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Wu, HR
   Fang, XY
   Jin, D
   Miao, RY
   Wei, JH
   Zhao, TY
   Dai, D
   Liao, JQ
   Wang, J
   Lian, FM
   Tian, JX
AF Wu, Haoran
   Fang, Xinyi
   Jin, De
   Miao, Runyu
   Wei, Jiahua
   Zhao, Tianyu
   Dai, Dan
   Liao, Jiangquan
   Wang, Jia
   Lian, Fengmei
   Tian, Jiaxing
TI Efficacy and Mechanism of the Jiangtang Tiaozhi Recipe in the Management
   of Type 2 Diabetes and Dyslipidaemia: A Clinical Trial Protocol
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE Jiangtang Tiaozhi recipe; type 2 diabetes; dyslipidaemia; clinical trial
   protocol; herbal medicine
ID CORONARY-HEART-DISEASE; RISK; PREVALENCE; PREDICTION; METFORMIN
AB Background: Type 2 diabetes mellitus (T2DM) complicated with dyslipidaemia is associated with a high risk of cardiovascular diseases. The Jiangtang Tiaozhi (JTTZ) recipe is a Chinese herbal formula that has been used to regulate the blood glucose and lipid levels for many years. Interestingly, a previous study has demonstrated its efficacy; however, the associated mechanism remains unclear. We hypothesised that the therapeutic effect of the JTTZ on patients with T2DM may be mediated by the modulation of metabolites secreted by the gut microbiota. This study aims to examine this mechanism.& nbsp;Methods and analysis: This study is a randomised, positive drug parallel-controlled, open-label clinical trial in patients with T2DM and dyslipidaemia. A total of 96 patients will be recruited and randomly assigned to treatment with JTTZ or metformin for 12 weeks. The primary outcome will be the rates of effectively regulated blood glucose and lipid levels (measured with the levels of glycated haemoglobin, fasting plasma glucose, 2-h plasma glucose, triglyceride, and low-density lipoprotein cholesterol). The secondary outcomes will be the changes in body weight, body mass index, and waist circumference and Traditional Chinese Medicine symptom scores. In addition, 16S rRNA gene sequencing will be performed on the gut microbiota obtained from faeces, and metabolomics analysis will be performed based on blood and gut microbiota samples. Intention-to-treat, per-protocol analysis and safety analysis will be performed.& nbsp;
C1 [Wu, Haoran; Fang, Xinyi; Jin, De; Miao, Runyu; Dai, Dan; Lian, Fengmei; Tian, Jiaxing] China Acad Chinese Med Sci, Guanganmen Hosp, Dept Endocrinol, Beijing, Peoples R China.
   [Wu, Haoran; Fang, Xinyi; Miao, Runyu] Beijing Univ Chinese Med, Grad Coll, Beijing, Peoples R China.
   [Wei, Jiahua] Changchun Univ Chinese Med, Grad Coll, Changchun, Peoples R China.
   [Zhao, Tianyu] Tianjin Univ Tradit Chinese Med, Dept Endocrinol, Teaching Hosp 1, Tianjin, Peoples R China.
   [Liao, Jiangquan] China Japan Friendship Hosp, Dept Natl Integrated Tradit, Beijing, Peoples R China.
   [Liao, Jiangquan] China Japan Friendship Hosp, Western Med Ctr Cardiovascular Dis, Beijing, Peoples R China.
   [Wang, Jia] China Acad Chinese Med Sci, Guanganmen Hosp, Dept Gen Med, Beijing, Peoples R China.
C3 China Academy of Chinese Medical Sciences; Guang'anmen Hospital, CACMS;
   Beijing University of Chinese Medicine; Changchun University of Chinese
   Medicine; Tianjin University of Traditional Chinese Medicine;
   China-Japan Friendship Hospital; China-Japan Friendship Hospital; China
   Academy of Chinese Medical Sciences; Guang'anmen Hospital, CACMS
RP Lian, FM; Tian, JX (通讯作者)，China Acad Chinese Med Sci, Guanganmen Hosp, Dept Endocrinol, Beijing, Peoples R China.
EM lfm565@sohu.com; tina_yai@126.com
FU National Natural Science Foundation of China [81904187]; Capital Health
   Development Research Project [CD 2020-4-4155]; CACMS Scientific and
   Technological Innovation Fund [CI 2021A01601]; Open Project of National
   Facility for Translational Medicine (Shanghai) [TMSK-2021-407];
   Innovation Team and Talents Cultivation Program of National
   Administration of Traditional Chinese Medicine [ZYYCXTD-D-202001];
   Outstanding Young Scientific and Technological Talents Program
   [ZZ13-YQ-026]
FX This work is supported by the National Natural Science Foundation of
   China (No. 81904187), Capital Health Development Research Project (CD
   2020-4-4155), CACMS Scientific and Technological Innovation Fund (CI
   2021A01601), Open Project of National Facility for Translational
   Medicine (Shanghai, TMSK-2021-407), Innovation Team and Talents
   Cultivation Program of National Administration of Traditional Chinese
   Medicine (No: ZYYCXTD-D-202001), and the Outstanding Young Scientific
   and Technological Talents Program (ZZ13-YQ-026). The design, management,
   analysis, and reporting of the study are independent of the funding
   programs.
CR Amer Diabet Assoc, 2020, DIABETES CARE, V43, pS111, DOI [10.2337/dc20-s010, 10.2337/dc20-S010]
   Cefalu WT, 2019, DIABETES CARE, V42, pS90, DOI 10.2337/dc19-S009
   Chan AW, 2013, BMJ-BRIT MED J, V346, DOI 10.1136/bmj.e7586
   中华医学会糖尿病学分会, 2021, [中华糖尿病杂志, Chinese Journal of Diabetes Mellitus], V13, P315
   Eliasson B, 2011, DIABETES CARE, V34, P2095, DOI 10.2337/dc11-0209
   Gerstein HC, 2005, DIABETOLOGIA, V48, P1749, DOI 10.1007/s00125-005-1858-4
   Gurung M, 2020, EBIOMEDICINE, V51, DOI 10.1016/j.ebiom.2019.11.051
   Jia WP, 2019, DIABETES-METAB RES, V35, DOI 10.1002/dmrr.3158
   Joint Committee for Chinese Adult Dyslipidemia Guidelines Revision, 2016, CHIN CIRC J, V31, P937
   Kuno T, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-19545-1
   Li YZ, 2020, BMJ-BRIT MED J, V369, DOI 10.1136/bmj.m997
   Lian FM, 2020, ANN PALLIAT MED, V9, P2237, DOI 10.21037/apm-19-271
   Pan L, 2016, ATHEROSCLEROSIS, V248, P2, DOI 10.1016/j.atherosclerosis.2016.02.006
   Petrie JR, 2020, DIABETES OBES METAB, V22, P904, DOI 10.1111/dom.13984
   Sanna S, 2019, NAT GENET, V51, P600, DOI 10.1038/s41588-019-0350-x
   Tong XL, 2018, MBIO, V9, DOI 10.1128/mBio.02392-17
   Turner RC, 1998, BMJ-BRIT MED J, V316, P823, DOI 10.1136/bmj.316.7134.823
   Wilson PWF, 1998, CIRCULATION, V97, P1837, DOI 10.1161/01.CIR.97.18.1837
   Wu HR, 2020, BMJ OPEN DIAB RES CA, V8, DOI 10.1136/bmjdrc-2020-001181
   Xu J, 2015, ISME J, V9, P552, DOI 10.1038/ismej.2014.177
   Xu T, 2015, DIABETES CARE, V38, P1858, DOI 10.2337/dc15-0658
   Yan L, 2016, J CLIN LIPIDOL, V10, P150, DOI 10.1016/j.jacl.2015.10.009
   Yu XT, 2018, INT J ENDOCRINOL, V2018, DOI 10.1155/2018/9519231
   Zhao X., 2013, EFFICACY ANAL JIANGT
NR 24
TC 0
Z9 0
U1 3
U2 11
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD FEB 4
PY 2022
VL 13
AR 827697
DI 10.3389/fphar.2022.827697
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA ZH6ET
UT WOS:000761030400001
PM 35185579
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Huang, F
   Nilholm, C
   Roth, B
   Linninge, C
   Hoglund, P
   Nyman, M
   Ohlsson, B
AF Huang, Fang
   Nilholm, Clara
   Roth, Bodil
   Linninge, Caroline
   Hoglund, Peter
   Nyman, Margareta
   Ohlsson, Bodil
TI Anthropometric and metabolic improvements in human type 2 diabetes after
   introduction of an Okinawan-based Nordic diet are not associated with
   changes in microbial diversity or SCFA concentrations
SO INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
LA English
DT Article
DE Enterobacteriaceae; microbial diversity; Okinawan-based Nordic diet;
   short-chain fatty acids (SCFA)
ID CHAIN FATTY-ACIDS; GLUCAGON-LIKE PEPTIDE-1; GUT MICROBIOTA; COLONIC
   FERMENTATION; LIPID-METABOLISM; GLUCOSE; FIBER; OBESITY; PROPIONATE;
   BACTERIA
AB The Okinawan-based Nordic (O-BN) diet improves anthropometry and metabolism in type 2 diabetes mellitus (T2DM) patients. The aim of this study was to study mechanisms behind improvements by examining Enterobacteriaceae abundance, microbial diversity, and concentrations of short-chain fatty acids (SCFAs). A secondary aim was exploring if metformin treatment affects microbiota or SCFAs. Thirty T2DM patients received the O-BN diet for 12weeks. Faecal and blood samples were collected at baseline, 12 and 28weeks. Although patients experienced weight loss and improved metabolic parameters, there were no significant changes in Enterobacteriaceae abundance or microbial diversity. Patients on metformin displayed higher Enterobacteriaceae abundance throughout the study (p=.008, p=.038, and p=.001, respectively). Isovaleric acid was decreased after 12weeks (p=.018). Butyric acid was decreased at follow-up (p=.007). Improved anthropometry and metabolism in T2DM after introduction of the O-BN diet is not associated with changes in Enterobacteriaceae abundance, microbial diversity or SCFA concentrations.
C1 [Huang, Fang; Nyman, Margareta] Lund Univ, Food Hlth Sci Ctr, Lund, Sweden.
   [Nilholm, Clara; Roth, Bodil; Ohlsson, Bodil] Lund Univ, Skane Univ Hosp, Dept Internal Med, Malmo, Sweden.
   [Linninge, Caroline] Lund Univ, Dept Food Technol Engn & Nutr, Lund, Sweden.
   [Hoglund, Peter] Lund Univ, Skane Univ Hosp, Dept Clin Chem & Pharmacol, Lund, Sweden.
C3 Lund University; Lund University; Skane University Hospital; Lund
   University; Lund University; Skane University Hospital
RP Nilholm, C (通讯作者)，Lund Univ, Skane Univ Hosp, Jan Waldenstroms St 15, S-20502 Malmo, Sweden.
EM ilh10cni@student.lu.se
RI Nyman, Margareta/AAY-9466-2020
OI Nyman, Margareta/0000-0003-3660-2364
FU Royal, Physiographic Society in Lund; Hans-Gabriel and Alice Trolle
   Wachtmeister's Foundation for Medical Research; Dir Albert Pahlsson's
   Foundation; Development Foundation of Region Skane; Foundation of Skane
   University Hospital, Ernold Lundstrom Foundation; King Gustaf V:s and
   queen Victoria Free Maison's Foundation
FX This study was supported by grants from the Royal, Physiographic Society
   in Lund, Hans-Gabriel and Alice Trolle Wachtmeister's Foundation for
   Medical Research, King Gustaf V:s and queen Victoria Free Maison's
   Foundation, Dir Albert Pahlsson's Foundation, Development Foundation of
   Region Skane, and Foundation of Skane University Hospital, Ernold
   Lundstrom Foundation.
CR Allin KH, 2015, EUR J ENDOCRINOL, V172, pR167, DOI 10.1530/EJE-14-0874
   Arora T, 2016, J INTERN MED, V280, P339, DOI 10.1111/joim.12508
   Baothman OA, 2016, LIPIDS HEALTH DIS, V15, DOI 10.1186/s12944-016-0278-4
   Bartosch S, 2004, APPL ENVIRON MICROB, V70, P3575, DOI 10.1128/AEM.70.6.3575-3581.2004
   Castillo M, 2006, VET MICROBIOL, V114, P165, DOI 10.1016/j.vetmic.2005.11.055
   Cuervo A, 2013, NUTR RES, V33, P811, DOI 10.1016/j.nutres.2013.05.016
   Cummings JH, 1997, JPEN-PARENTER ENTER, V21, P357, DOI 10.1177/0148607197021006357
   Darwiche G, 2016, FOOD NUTR RES, V60, DOI 10.3402/fnr.v60.32594
   den Besten G, 2013, AM J PHYSIOL-GASTR L, V305, pG900, DOI 10.1152/ajpgi.00265.2013
   Flint HJ, 2012, NAT REV GASTRO HEPAT, V9, P577, DOI 10.1038/nrgastro.2012.156
   Freeland KR, 2010, BRIT J NUTR, V103, P460, DOI 10.1017/S0007114509991863
   Freeland KR, 2010, BRIT J NUTR, V103, P82, DOI 10.1017/S0007114509991462
   Gao ZG, 2009, DIABETES, V58, P1509, DOI 10.2337/db08-1637
   Graf Daniela, 2015, Microbial Ecology in Health and Disease, V26, P26164, DOI 10.3402/mehd.v26.26164
   Holman RR, 2008, NEW ENGL J MED, V359, P1577, DOI 10.1056/NEJMoa0806470
   Ibrugger S, 2014, APPETITE, V80, P248, DOI 10.1016/j.appet.2014.05.026
   Jakobsdottir G, 2013, BRIT J NUTR, V110, P1565, DOI 10.1017/S0007114513000809
   Jakobsdottir G, 2013, SCAND J GASTROENTERO, V48, P696, DOI 10.3109/00365521.2013.786128
   Karaderi T, 2015, CURR DIABETES REP, V15, DOI 10.1007/s11892-015-0648-8
   Karlsson CLJ, 2012, OBESITY, V20, P2257, DOI 10.1038/oby.2012.110
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Knowler WC, 2002, NEW ENGL J MED, V346, P393, DOI 10.1056/NEJMoa012512
   KNOWLES SE, 1974, BIOCHEM J, V142, P401, DOI 10.1042/bj1420401
   Krishnan B, 2013, WORLD J DIABETES, V4, P51, DOI 10.4239/wjd.v4.i3.51
   LAURENT C, 1995, EUR J CLIN NUTR, V49, P484
   Ley RE, 2005, P NATL ACAD SCI USA, V102, P11070, DOI 10.1073/pnas.0504978102
   Macfarlane GT, 2012, J AOAC INT, V95, P50, DOI 10.5740/jaoacint.SGE_Macfarlane
   Magurran AE., 2004, MEASURING BIOL DIVER
   Nordic Council of Ministers, 2012, NORD NUTR REC
   Ohlsson B, 2016, NUTR RES, V36, P359, DOI 10.1016/j.nutres.2015.12.004
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Rios-Covian D, 2016, FRONT MICROBIOL, V7, DOI 10.3389/fmicb.2016.00185
   Rodriguez-Carrio J, 2017, FRONT IMMUNOL, V8, DOI 10.3389/fimmu.2017.00023
   ROEDIGER WEW, 1982, GASTROENTEROLOGY, V83, P424
   Sand Elin, 2015, BMC Res Notes, V8, P824, DOI 10.1186/s13104-015-1800-x
   Santacruz A, 2010, BRIT J NUTR, V104, P83, DOI 10.1017/S0007114510000176
   Shen W, 2014, J NUTR BIOCHEM, V25, P270, DOI 10.1016/j.jnutbio.2013.09.009
   Slavin JL, 2005, NUTRITION, V21, P411, DOI 10.1016/j.nut.2004.08.018
   Stenblom EL, 2016, NUTR METAB, V13, DOI 10.1186/s12986-016-0128-4
   Subramanian S, 2012, BBA-MOL CELL BIOL L, V1821, P819, DOI 10.1016/j.bbalip.2011.10.003
   Suez J, 2014, NATURE, V514, P181, DOI 10.1038/nature13793
   TODESCO T, 1991, AM J CLIN NUTR, V54, P860, DOI 10.1093/ajcn/54.5.860
   Turnbaugh PJ, 2008, CELL HOST MICROBE, V3, P213, DOI 10.1016/j.chom.2008.02.015
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   VENTER CS, 1990, AM J GASTROENTEROL, V85, P549
   Vetrani C, 2016, NUTRITION, V32, P217, DOI 10.1016/j.nut.2015.08.006
   Walker AW, 2011, ISME J, V5, P220, DOI 10.1038/ISMEJ.2010.118
   Wang M, 2008, J ALLERGY CLIN IMMUN, V121, P129, DOI 10.1016/j.jaci.2007.09.011
   Willcox DC, 2014, MECH AGEING DEV, V136, P148, DOI 10.1016/j.mad.2014.01.002
   Wolever TMS, 1996, J NUTR, V126, P2790
   Wu GD, 2011, SCIENCE, V334, P105, DOI 10.1126/science.1208344
   Zhao GH, 2007, J CHROMATOGR B, V846, P202, DOI 10.1016/j.jchromb.2006.09.027
   Zhu BL, 2010, PROTEIN CELL, V1, P718, DOI 10.1007/s13238-010-0093-z
NR 53
TC 12
Z9 13
U1 0
U2 15
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0963-7486
EI 1465-3478
J9 INT J FOOD SCI NUTR
JI Int. J. Food Sci. Nutr.
PY 2018
VL 69
IS 6
BP 729
EP 740
DI 10.1080/09637486.2017.1408059
PG 12
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA GM0DW
UT WOS:000437718300010
PM 29199483
DA 2023-06-08
ER

PT J
AU Sun, X
   Chi, X
   Zhao, YY
   Liu, SA
   Xing, HC
AF Sun, Xiu
   Chi, Xin
   Zhao, Yingying
   Liu, Shunai
   Xing, Huichun
TI Characteristics and Clinical Significance of Intestinal Microbiota in
   Patients with Chronic Hepatitis B Cirrhosis and Type 2 Diabetes Mellitus
SO JOURNAL OF DIABETES RESEARCH
LA English
DT Article
ID GUT MICROBIOTA; HEPATOCELLULAR-CARCINOMA; METFORMIN
AB Background. Chronic hepatitis B cirrhosis is often accompanied by glucose metabolism disorder, and intestinal microbiota was closely related to both cirrhosis and diabetes. There are few studies on the role of intestinal microbiota in hepatitis B liver cirrhosis and diabetes mellitus (LCDM). The purpose of this study was to investigate the characteristics of intestinal microbiota in patients with LCDM and to evaluate the relationship between the severity of intestinal microbiota imbalance and clinical significance. Methods. A case-controlled study was conducted. People who met the inclusion and exclusion criteria of chronic HBV-related liver cirrhosis (LC), LCDM, and healthy controls (HC) were enrolled in, and their fecal and blood samples were collected. The V3-V4 region of 16s rDNA gene of fecal microbiota was sequenced; the bioinformatics analysis including alpha-diversity, beta-diversity, and linear discriminant analysis (LDA) effect size (LEfSe) was performed; and the correlation between bacteria and clinical indexes was analyzed. Results. A total of 70 participants completed fecal and blood tests, including 20 HC, 20 LCDM, and 30 LC. The alpha diversity of intestinal microbiota in the LCDM decreased than that in the HC. The abundance of Proteobacteria, Streptococcus, Escherichia-Shigella, and Lactobacillus increased, while the abundance of Bacteroidota, Bacteroides, Prevotella, Faecalibacterium, and Lachnospira decreased in the LCDM compared with the HC. The abundance of Lactobacillus, Roseburia, and Veillonella and the degree of hepatitis B cirrhosis dysbiosis indicator (HBCDI) increased in the LCDM than in the LC. The abundance of Escherichia-Shigella, Veillonella, and Lactobacillus positively correlated with liver injury and fasting blood glucose (FBG) level. The abundance of Escherichia-Shigella, Veillonella, Streptococcus, and Lactobacillus increased more significantly when FBG and glycosylated hemoglobin level increased. Conclusion. Intestinal microbiota of patients with LCDM was significantly disordered, and the degree was more serious than that cirrhosis patients without diabetes.
C1 [Sun, Xiu; Chi, Xin; Zhao, Yingying; Xing, Huichun] Capital Med Univ, Beijing Ditan Hosp, Ctr Liver Dis Div 3, Beijing, Peoples R China.
   [Zhao, Yingying; Liu, Shunai; Xing, Huichun] Natl Ctr Infect Dis, Beijing, Peoples R China.
   [Liu, Shunai] Capital Med Univ, Beijing Ditan Hosp, Inst Infect Dis, Beijing Key Lab Emerging Infect Dis, Beijing, Peoples R China.
   [Xing, Huichun] Peking Univ, Ditan Teaching Hosp, Beijing, Peoples R China.
C3 Capital Medical University; Capital Medical University; Peking
   University
RP Xing, HC (通讯作者)，Capital Med Univ, Beijing Ditan Hosp, Ctr Liver Dis Div 3, Beijing, Peoples R China.; Xing, HC (通讯作者)，Natl Ctr Infect Dis, Beijing, Peoples R China.; Xing, HC (通讯作者)，Peking Univ, Ditan Teaching Hosp, Beijing, Peoples R China.
EM xiusun2021@163.com; 1553932446@qq.com; zhaoyy0504@163.com;
   liusa1031@ccmu.edu.cn; hchxing@sohu.com
OI Sun, Xiu/0000-0002-6192-697X
FU National Science and Technology Major Project of China
   [2018ZX10302-206-003-006]; Capital's Funds for Health Improvement and
   Research of China [CFH 2020-1-2171]; Digestive Medical Coordinated
   Development Center of Beijing Hospitals Authority [XXT26]; National Key
   R&D Program of China [2021YFC2301800]; Beijing Hospitals Authority
   Clinical Medicine Development [XMLX201837]
FX We thank all patients and healthy volunteers for their participation in
   this study. This work was supported by the National Science and
   Technology Major Project of China under Grant (2018ZX10302-206-003-006),
   the Capital's Funds for Health Improvement and Research of China (CFH
   2020-1-2171), the Digestive Medical Coordinated Development Center of
   Beijing Hospitals Authority under Grant (XXT26), the Beijing Hospitals
   Authority Clinical Medicine Development of special funding support under
   Grant (XMLX201837), and the National Key R&D Program of China
   (2021YFC2301800).
CR Anhe FF, 2021, CELL REP, V36, DOI 10.1016/j.celrep.2021.109691
   Arab JP, 2018, HEPATOL INT, V12, pS24, DOI 10.1007/s12072-017-9798-x
   Bajaj JS, 2014, ALIMENT PHARM THER, V39, P1113, DOI 10.1111/apt.12695
   Belcheva A, 2014, CELL, V158, P288, DOI 10.1016/j.cell.2014.04.051
   Bertuccio P, 2017, J HEPATOL, V67, P302, DOI 10.1016/j.jhep.2017.03.011
   Blandino G, 2016, DIABETES METAB, V42, P303, DOI 10.1016/j.diabet.2016.04.004
   Candela M, 2016, BRIT J NUTR, V116, P80, DOI 10.1017/S0007114516001045
   Cani PD, 2019, NAT METAB, V1, P34, DOI 10.1038/s42255-018-0017-4
   Chen ZL, 2021, JAMA NETW OPEN, V4, DOI 10.1001/jamanetworkopen.2021.18811
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Elkrief L, 2016, LIVER INT, V36, P936, DOI 10.1111/liv.13115
   Gurung M, 2020, EBIOMEDICINE, V51, DOI 10.1016/j.ebiom.2019.11.051
   Huang YW, 2013, CLIN INFECT DIS, V57, P1695, DOI 10.1093/cid/cit603
   Lavanchy D, 2004, J VIRAL HEPATITIS, V11, P97, DOI 10.1046/j.1365-2893.2003.00487.x
   Le KA, 2013, FRONT PHYSIOL, V3, DOI 10.3389/fphys.2012.00496
   Lee WG, 2019, DIABETES-METAB RES, V35, DOI 10.1002/dmrr.3157
   Levy M, 2017, CURR OPIN MICROBIOL, V35, P8, DOI 10.1016/j.mib.2016.10.003
   Long B.W.L.K.J., 2018, SHIJIE HUAREN, V26, P986, DOI [10.11569/wcjd.v26.i16.986, DOI 10.11569/WCJD.V26.I16.986]
   Loomba R, 2021, HEPATOLOGY, V73, P126, DOI 10.1002/hep.31523
   Lu HF, 2011, MICROB ECOL, V61, P693, DOI 10.1007/s00248-010-9801-8
   Pinna NK, 2021, GENOME MED, V13, DOI 10.1186/s13073-021-00851-9
   Poppleton DI, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.01215
   Qin JJ, 2010, NATURE, V464, P59, DOI 10.1038/nature08821
   Sun X, 2021, HEPATOL INT, V15, P1053, DOI 10.1007/s12072-021-10230-6
   Tamanai-Shacoori Z, 2017, FUTURE MICROBIOL, V12, P157, DOI 10.2217/fmb-2016-0130
   Tan YF, 2019, CANCER MANAG RES, V11, P705, DOI 10.2147/CMAR.S188238
   Vital M, 2014, MBIO, V5, DOI 10.1128/mBio.00889-14
   Wei X, 2013, BMC GASTROENTEROL, V13, DOI 10.1186/1471-230X-13-175
   Wu H, 2020, CELL METAB, V32, P379, DOI 10.1016/j.cmet.2020.06.011
   Yixuan W., 2019, CHINESE J LIVER DIS, V11, P8
   Zhang CC, 2022, CLIN NUTR, V41, P365, DOI 10.1016/j.clnu.2021.11.037
   Zhang J, 2015, ISME J, V9, P1979, DOI 10.1038/ismej.2015.11
   Zhang XD, 2014, HEPATOLOGY, V60, P2008, DOI 10.1002/hep.27199
   Zhao YY, 2019, J DIABETES RES, V2019, DOI 10.1155/2019/6430486
   Zhong HZ, 2019, EBIOMEDICINE, V47, P373, DOI 10.1016/j.ebiom.2019.08.048
NR 35
TC 0
Z9 0
U1 1
U2 5
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6745
EI 2314-6753
J9 J DIABETES RES
JI J. Diabetes Res.
PD MAY 13
PY 2022
VL 2022
AR 1826181
DI 10.1155/2022/1826181
PG 14
WC Endocrinology & Metabolism; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Research & Experimental Medicine
GA 1Q4KT
UT WOS:000802659100002
PM 35601017
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Maskarinec, G
   Raquinio, P
   Kristal, BS
   Setiawan, VW
   Wilkens, LR
   Franke, AA
   Lim, U
   Le Marchand, L
   Randolph, TW
   Lampe, JW
   Hullar, MAJ
AF Maskarinec, Gertraud
   Raquinio, Phyllis
   Kristal, Bruce S.
   Setiawan, Veronica W.
   Wilkens, Lynne R.
   Franke, Adrian A.
   Lim, Unhee
   Le Marchand, Loic
   Randolph, Timothy W.
   Lampe, Johanna W.
   Hullar, Meredith A. J.
TI The gut microbiome and type 2 diabetes status in the Multiethnic Cohort
SO PLOS ONE
LA English
DT Article
ID DIET-QUALITY INDEXES; METFORMIN; RISK; COMMUNITIES; METAGENOME;
   BACTERIA; SEARCH
AB Background The gut microbiome may play a role in inflammation associated with type 2 diabetes (T2D) development. This cross-sectional study examined its relation with glycemic status within a subset of the Multiethnic Cohort (MEC) and estimated the association of circulating bacterial endotoxin (measured as plasma lipopolysaccharide-binding protein (LBP)) with T2D, which may be mediated by C-reactive protein (CRP). Methods In 2013-16, cohort members from five ethnic groups completed clinic visits, questionnaires, and stool and blood collections. Participants with self-reported T2D and/or taking medication were considered T2D cases. Those with fasting glucose >125 and 100-125 mg/dL were classified as undiagnosed (UT2D) and pre-diabetes (PT2D) cases, respectively. We characterized the gut microbiome through 16S rRNA gene sequencing and measured plasma LBP and CRP by standard assays. Linear regression was applied to estimate associations of the gut microbiome community structure and LBP with T2D status adjusting for relevant confounders. Results Among 1,702 participants (59.9-77.4 years), 735 (43%) were normoglycemic (NG), 506 (30%) PT2D, 154 (9%) UT2D, and 307 (18%) T2D. The Shannon diversity index decreased (p(trend) = 0.05), while endotoxin, measured as LBP, increased (p(trend) = 0.0003) from NG to T2D. Of 10 phyla, Actinobacteria (p(trend) = 0.007), Firmicutes (p(trend) = 0.003), and Synergistetes (p(trend) = 0.02) were inversely associated and Lentisphaerae (p(trend) = 0.01) was positively associated with T2D status. Clostridium sensu stricto 1, Lachnospira, and Peptostreptococcaceae were less, while Escherichia-Shigella and Lachnospiraceae were more abundant among T2D patients, but the associations with Actinobacteria, Clostridium sensu stricto 1, and Escherichia-Shigella may be due metformin use. PT2D/UT2D values were closer to NG than T2D. No indication was detected that CRP mediated the association of LBP with T2D. Conclusions T2D but not PT2D/UT2D status was associated with lower abundance of SCFA-producing genera and a higher abundance of gram-negative endotoxin-producing bacteria suggesting that the gut microbiome may contribute to chronic systemic inflammation and T2D through bacterial translocation.
C1 [Maskarinec, Gertraud; Raquinio, Phyllis; Wilkens, Lynne R.; Franke, Adrian A.; Lim, Unhee; Le Marchand, Loic] Univ Hawaii, Canc Ctr, Populat Sci Pacific, Honolulu, HI 96822 USA.
   [Kristal, Bruce S.] Brigham & Womens Hosp, 75 Francis St, Boston, MA 02115 USA.
   [Kristal, Bruce S.] Harvard Med Sch, Boston, MA 02115 USA.
   [Setiawan, Veronica W.] Univ Southern Calif, Dept Prevent Med, Los Angeles, CA 90007 USA.
   [Randolph, Timothy W.; Lampe, Johanna W.; Hullar, Meredith A. J.] Fred Hutchinson Canc Res Ctr, Publ Hlth Sci Div, 1124 Columbia St, Seattle, WA 98104 USA.
C3 Cancer Research Center of Hawaii; University of Hawaii System; Harvard
   University; Brigham & Women's Hospital; Harvard University; Harvard
   Medical School; University of Southern California; Fred Hutchinson
   Cancer Center
RP Maskarinec, G (通讯作者)，Univ Hawaii, Canc Ctr, Populat Sci Pacific, Honolulu, HI 96822 USA.
EM gertraud@cc.hawaii.edu
RI Lim, Unhee/AEA-8591-2022
OI Lim, Unhee/0000-0001-6221-7190; Maskarinec, Gertraud/0000-0002-8129-958X
FU National Cancer Institute [P01CA169530, U01CA164973, P30CA071789,
   P30CA015704]; National Center for Advancing Translational Sciences
   [UL1TR000130]; National Institute of Diabetes and Digestive and Kidney
   Diseases [R01HL140335]
FX This research was funded by the following grants: National Cancer
   Institute (https://www.cancer.gov/) P01CA169530 (LLM) U01CA164973 (LLM)
   P30CA071789 (RH) P30CA015704 (TJL) National Center for Advancing
   Translational Sciences (https://ncats.nih.gov/) UL1TR000130 (TAB)
   National Institute of Diabetes and Digestive and Kidney Diseases
   (https://www.niddk.nih.gov/) R01HL140335 (BSK) The funders had no role
   in study design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
CR Ahmad A, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0226372
   ALTSCHUL SF, 1990, J MOL BIOL, V215, P403, DOI 10.1006/jmbi.1990.9999
   Amer Diabet Assoc, 2014, DIABETES CARE, V37, pS81, DOI [10.2337/dc13-S067, 10.2337/dc14-S081, 10.2337/dc13-S011, 10.2337/dc10-S062, 10.2337/dc10-S011, 10.2337/dc11-S062, 10.2337/dc12-s064, 10.2337/dc11-S011]
   Anderson MJ, 2006, BIOMETRICS, V62, P245, DOI 10.1111/j.1541-0420.2005.00440.x
   Boulange CL, 2016, GENOME MED, V8, DOI 10.1186/s13073-016-0303-2
   Brunkwall L, 2017, DIABETOLOGIA, V60, P943, DOI 10.1007/s00125-017-4278-3
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   Caporaso JG, 2010, NAT METHODS, V7, P335, DOI 10.1038/nmeth.f.303
   Caporaso JG, 2010, BIOINFORMATICS, V26, P266, DOI 10.1093/bioinformatics/btp636
   Chapkin RS, 2020, DIGEST DIS SCI, V65, P840, DOI 10.1007/s10620-020-06106-8
   Chavez-Carbajal A, 2020, MICROORGANISMS, V8, DOI 10.3390/microorganisms8010094
   Chen L, 2018, FRONT PHARMACOL, V9, DOI 10.3389/fphar.2018.00761
   Citronberg JS, 2018, ISME J, V12, P1631, DOI 10.1038/s41396-018-0064-6
   Clemente-Postigo M, 2012, J LIPID RES, V53, P973, DOI 10.1194/jlr.P020909
   Clooney AG, 2021, GUT, V70, P499, DOI 10.1136/gutjnl-2020-321106
   Currie CJ, 2009, DIABETOLOGIA, V52, P1766, DOI 10.1007/s00125-009-1440-6
   Dewulf EM, 2013, GUT, V62, P1112, DOI 10.1136/gutjnl-2012-303304
   Di Fusco D, 2018, CLIN SCI, V132, P1155, DOI 10.1042/CS20180167
   Doumatey AP, 2020, FRONT CELL INFECT MI, V10, DOI 10.3389/fcimb.2020.00063
   Duncan SH, 2002, APPL ENVIRON MICROB, V68, P5186, DOI 10.1128/AEM.68.10.5186-5190.2002
   Edgar RC, 2010, BIOINFORMATICS, V26, P2460, DOI 10.1093/bioinformatics/btq461
   Ericson U, 2020, J NUTR, V150, P861, DOI 10.1093/jn/nxz293
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Fu BC, 2019, CANCER EPIDEM BIOMAR, V28, P154, DOI 10.1158/1055-9965.EPI-18-0348
   Gaike AH, 2020, MSYSTEMS, V5, DOI 10.1128/mSystems.00578-19
   Gloor GB, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.02224
   Gomez-Arango LF, 2016, DIABETES, V65, P2214, DOI 10.2337/db16-0278
   Guo PT, 2020, J ANIM SCI BIOTECHNO, V11, DOI 10.1186/s40104-019-0402-1
   Harmon BE, 2015, AM J CLIN NUTR, V101, P587, DOI 10.3945/ajcn.114.090688
   Hu FB, 2004, DIABETES, V53, P693, DOI 10.2337/diabetes.53.3.693
   Huang C, 2015, J NUTR, V145, P2774, DOI 10.3945/jn.115.217406
   Jacobs S, 2017, BRIT J NUTR, V118, P312, DOI [10.1017/S0007114517002033, 10.1017/s0007114517002033]
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kelly CJ, 2015, CELL HOST MICROBE, V17, P662, DOI 10.1016/j.chom.2015.03.005
   Knol MJ, 2012, INT J EPIDEMIOL, V41, P514, DOI 10.1093/ije/dyr218
   Kolonel LN, 2000, AM J EPIDEMIOL, V151, P346, DOI 10.1093/oxfordjournals.aje.a010213
   Lambeth Stacey M, 2015, J Diabetes Obes, V2, P1
   Langille MGI, 2013, NAT BIOTECHNOL, V31, P814, DOI 10.1038/nbt.2676
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Le Marchand L, 2020, CANCER EPIDEM BIOMAR, V29, P966, DOI 10.1158/1055-9965.EPI-19-1469
   Lim U, 2019, GASTROENTEROLOGY, V156, P966, DOI 10.1053/j.gastro.2018.11.021
   Luo HZ, 2018, BIORESOURCE TECHNOL, V253, P343, DOI 10.1016/j.biortech.2018.01.007
   Ma X, 2012, J ANIM SCI, V90, P266, DOI 10.2527/jas.50965
   Mehta NN, 2010, DIABETES, V59, P172, DOI 10.2337/db09-0367
   Nakano K, 2006, J CLIN MICROBIOL, V44, P3313, DOI 10.1128/JCM.00377-06
   Navas-Molina JA, 2013, METHOD ENZYMOL, V531, P371, DOI 10.1016/B978-0-12-407863-5.00019-8
   Nelson MC, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0094249
   O'Keefe SJD, 2016, NAT REV GASTRO HEPAT, V13, P691, DOI 10.1038/nrgastro.2016.165
   Owen MR, 2000, BIOCHEM J, V348, P607, DOI 10.1042/0264-6021:3480607
   Pedersen C, 2016, BRIT J NUTR, V116, P1869, DOI 10.1017/S0007114516004086
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Ridlon JM, 2006, J LIPID RES, V47, P241, DOI 10.1194/jlr.R500013-JLR200
   Sato J, 2014, DIABETES CARE, V37, P2343, DOI 10.2337/dc13-2817
   Schloss PD, 2009, APPL ENVIRON MICROB, V75, P7537, DOI 10.1128/AEM.01541-09
   Sepp E, 2014, MICROB ECOL HEALTH D, V25, DOI 10.3402/mehd.v25.22857
   Shoaie S, 2015, CELL METAB, V22, P320, DOI 10.1016/j.cmet.2015.07.001
   Skovso S, 2015, INT J OBESITY, V39, P1531, DOI 10.1038/ijo.2015.92
   Song RS, 2016, DIABETES CARE, V39, P187, DOI 10.2337/dci15-0013
   Thingholm LB, 2019, CELL HOST MICROBE, V26, P252, DOI 10.1016/j.chom.2019.07.004
   Utzschneider KM, 2016, J CLIN ENDOCR METAB, V101, P2622, DOI 10.1210/jc.2015-4251
   Vital M, 2014, MBIO, V5, DOI 10.1128/mBio.00889-14
   Wang K, 2016, SCI REP-UK, V6, DOI 10.1038/srep34360
   Wen L, 2017, J NUTR, V147, p1468S, DOI 10.3945/jn.116.240754
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Wu XK, 2010, CURR MICROBIOL, V61, P69, DOI 10.1007/s00284-010-9582-9
   Zhang FH, 2019, ENDOCRINE, V66, P485, DOI 10.1007/s12020-019-02041-5
   Zhang XY, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0071108
   Zhang YQ, 2020, NAR GENOM BIOINFORM, V2, DOI 10.1093/nargab/lqaa078
NR 68
TC 12
Z9 14
U1 1
U2 11
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUN 23
PY 2021
VL 16
IS 6
AR e0250855
DI 10.1371/journal.pone.0250855
PG 15
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA TG9BO
UT WOS:000671691900032
PM 34161346
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Moffa, S
   Mezza, T
   Cefalo, CMA
   Cinti, F
   Impronta, F
   Sorice, GP
   Santoro, A
   Di Giuseppe, G
   Pontecorvi, A
   Giaccari, A
AF Moffa, Simona
   Mezza, Teresa
   Cefalo, Chiara M. A.
   Cinti, Francesca
   Impronta, Flavia
   Sorice, Gian Pio
   Santoro, Antonio
   Di Giuseppe, Gianfranco
   Pontecorvi, Alfredo
   Giaccari, Andrea
TI The Interplay between Immune System and Microbiota in Diabetes
SO MEDIATORS OF INFLAMMATION
LA English
DT Review
ID DIET-INDUCED OBESITY; BETA-CELL FUNCTION; GUT MICROBIOTA; INTESTINAL
   MICROBIOTA; INSULIN SENSITIVITY; METFORMIN; MICE; INFLAMMATION;
   HOMEOSTASIS; BACTERIA
AB Diabetes is not a single and homogeneous disease, but a cluster of metabolic diseases characterized by the common feature of hyperglycemia. The pathogenesis of type 1 diabetes (T1D) and type 2 diabetes (T2D) (and all other intermediate forms of diabetes) involves the immune system, in terms of inflammation and autoimmunity. The past decades have seen an increase in all types of diabetes, accompanied by changes in eating habits and consequently a structural evolution of gut microbiota. It is likely that all these events could be related and that gut microbiota alterations might be involved in the immunomodulation of diabetes. Thus, gut microbiota seems to have a direct, even causative role in mediating connections between the environment, food intake, and chronic disease. As many conditions that increase the risk of diabetes modulate gut microbiota composition, it is likely that immune-mediated reactions, induced by alterations in the composition of the microbiota, can act as facilitators for the onset of diabetes in predisposed subjects. In this review, we summarize recent evidence in the field of gut microbiota and the role of the latter in modulating the immune reactions involved in the pathogenesis of diabetes.
C1 [Moffa, Simona; Mezza, Teresa; Cefalo, Chiara M. A.; Cinti, Francesca; Impronta, Flavia; Sorice, Gian Pio; Santoro, Antonio; Di Giuseppe, Gianfranco; Pontecorvi, Alfredo; Giaccari, Andrea] Univ Cattolica Sacro Cuore, Ctr Malattie Endocrine & Metab, UOC Endocrinol & Diabetol, Fdn Policlin Univ A Gemelli IRCCS, Rome, Italy.
   [Moffa, Simona; Mezza, Teresa; Cefalo, Chiara M. A.; Cinti, Francesca; Impronta, Flavia; Sorice, Gian Pio; Santoro, Antonio; Di Giuseppe, Gianfranco; Pontecorvi, Alfredo; Giaccari, Andrea] Univ Cattolica Sacro Cuore, Ist Patol Speciale Med & Semeiot Med, Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli
RP Giaccari, A (通讯作者)，Univ Cattolica Sacro Cuore, Ctr Malattie Endocrine & Metab, UOC Endocrinol & Diabetol, Fdn Policlin Univ A Gemelli IRCCS, Rome, Italy.
EM andrea.giaccari@unicatt.it
RI Cinti, Francesca/AAY-5534-2021; Cefalo, Chiara Maria
   Assunta/AAB-3308-2022; Giaccari, Andrea/AAA-7824-2022; Cefalo, Chiara
   Maria Assunta/AAA-3429-2022
OI Cinti, Francesca/0000-0001-5170-7055; Cefalo, Chiara Maria
   Assunta/0000-0002-8665-8406; Giaccari, Andrea/0000-0002-7462-7792; Di
   Giuseppe, Gianfranco/0000-0003-4506-5193; Santoro,
   Antonio/0000-0002-8911-7007
FU Universita Cattolica del Sacro Cuore; Italian Ministry of Education,
   University and Research [PRIN 2015373Z39_006]; European Foundation for
   the Study of Diabetes; Eli Lilly and Company; Astra-Zeneca; Novo
   Nordisk; Fondazione AMD (Borse di Studio in Memoria di Adolfo
   Arcangeli); Diabete Ricerca
FX We thank Serena Rotunno for providing editorial assistance in the
   preparation of this manuscript. This study was supported by grants from
   the Universita Cattolica del Sacro Cuore (Fondi Ateneo Linea D.3.2 and
   Fondi Ateneo Linea D.1, anno 2019) and the Italian Ministry of
   Education, University and Research (PRIN 2015373Z39_006) and awards from
   the European Foundation for the Study of Diabetes, Novo Nordisk, Eli
   Lilly and Company, and Astra-Zeneca (to T.M.). C.M.A. is the recipient
   of a fellowship prize from Diabete Ricerca and from Fondazione AMD
   (Borse di Studio in Memoria di Adolfo Arcangeli).
CR Ali M, 2017, AM J PATHOL, V187, P2590, DOI [10.1016/j.ajPath.2017.07.021, 10.1016/j.ajpath.2017.07.021]
   Backhed F, 2007, P NATL ACAD SCI USA, V104, P979, DOI 10.1073/pnas.0605374104
   Beretta MV, 2018, ARCH ENDOCRIN METAB, V62, P47, DOI 10.20945/2359-3997000000008
   Bridges HR, 2014, BIOCHEM J, V462, P475, DOI 10.1042/BJ20140620
   Brugman S, 2006, DIABETOLOGIA, V49, P2105, DOI 10.1007/s00125-006-0334-0
   Burcelin R, 2011, ACTA DIABETOL, V48, P257, DOI 10.1007/s00592-011-0333-6
   Burrows MP, 2015, P NATL ACAD SCI USA, V112, P9973, DOI 10.1073/pnas.1508740112
   Campbell SC, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0150502
   Canani RB, 2015, CURR OPIN ALLERGY CL, V15, P243, DOI 10.1097/ACI.0000000000000157
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   Cardwell CR, 2008, DIABETOLOGIA, V51, P726, DOI 10.1007/s00125-008-0941-z
   Cefalu WT, 2019, DIABETES CARE, V42, pS13, DOI 10.2337/dc19-S002
   Codella R, 2015, J DIABETES RES, V2015, DOI 10.1155/2015/737586
   Davis-Richardson AG, 2014, FRONT MICROBIOL, V5, DOI 10.3389/fmicb.2014.00678
   Dehghan P, 2013, HEALTH PROMOT PERSPE, V3, P55, DOI 10.5681/hpp.2013.007
   Depommier C, 2019, NAT MED, V25, P1096, DOI 10.1038/s41591-019-0495-2
   Ejtahed HS, 2012, NUTRITION, V28, P539, DOI 10.1016/j.nut.2011.08.013
   Estaki M, 2016, MICROBIOME, V4, DOI 10.1186/s40168-016-0189-7
   Mejia-Leon ME, 2014, SCI REP-UK, V4, DOI 10.1038/srep03814
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Frank DN, 2007, P NATL ACAD SCI USA, V104, P13780, DOI 10.1073/pnas.0706625104
   Gao ZG, 2009, DIABETES, V58, P1509, DOI 10.2337/db08-1637
   Holmberg H, 2007, BRIT J NUTR, V97, P111, DOI 10.1017/S0007114507210189
   Hooper LV, 2010, NAT REV IMMUNOL, V10, P159, DOI 10.1038/nri2710
   Hotamisligil GS, 2006, NATURE, V444, P860, DOI 10.1038/nature05485
   Hsu YJ, 2015, J STRENGTH COND RES, V29, P552, DOI 10.1519/JSC.0000000000000644
   Imanishi T, 2007, J IMMUNOL, V178, P6715, DOI 10.4049/jimmunol.178.11.6715
   Kim MS, 2013, ENV MICROBIOL REP, V5, P765, DOI 10.1111/1758-2229.12079
   Kolb H, 2005, DIABETOLOGIA, V48, P1038, DOI 10.1007/s00125-005-1764-9
   Kriegel MA, 2011, P NATL ACAD SCI USA, V108, P11548, DOI 10.1073/pnas.1108924108
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Lau K, 2011, J IMMUNOL, V186, P3538, DOI 10.4049/jimmunol.1001864
   Lee AS, 2010, DIABETOLOGIA, V53, P741, DOI 10.1007/s00125-009-1626-y
   Ley RE, 2006, NATURE, V444, P1022, DOI 10.1038/4441022a
   Li YY, 2017, J AUTOIMMUN, V82, P85, DOI 10.1016/j.jaut.2017.05.007
   Libman Ingrid M, 2003, Pediatr Diabetes, V4, P110, DOI 10.1034/j.1399-5448.2003.00012.x
   Lu K, 2014, ENVIRON HEALTH PERSP, V122, P284, DOI 10.1289/ehp.1307429
   Marek-Trzonkowska N, 2012, DIABETES CARE, V35, P1817, DOI 10.2337/dc12-0038
   Marietta EV, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0078687
   Martin-Orozco N, 2009, EUR J IMMUNOL, V39, P216, DOI 10.1002/eji.200838475
   McCreight LJ, 2016, DIABETOLOGIA, V59, P426, DOI 10.1007/s00125-015-3844-9
   Melhem H, 2019, CELLS-BASEL, V8, DOI 10.3390/cells8050450
   Murphy EF, 2010, GUT, V59, P1635, DOI 10.1136/gut.2010.215665
   Myers MA, 2003, ANN NY ACAD SCI, V1005, P418, DOI 10.1196/annals.1288.071
   Neal MD, 2006, J IMMUNOL, V176, P3070, DOI 10.4049/jimmunol.176.5.3070
   Neel BA, 2011, DIABETES, V60, P1838, DOI 10.2337/db11-0153
   Neuman V, 2019, DIABETOLOGIA, V62, P1291, DOI 10.1007/s00125-019-4869-2
   Pasini E, 2019, MINERVA MED, V110, P3, DOI 10.23736/S0026-4806.18.05589-1
   Peng J, 2014, J AUTOIMMUN, V53, P85, DOI 10.1016/j.jaut.2014.03.005
   Pineiro M, 2008, J CLIN GASTROENTEROL, V42, pS156, DOI 10.1097/MCG.0b013e31817f184e
   Plovier H, 2017, NAT MED, V23, P107, DOI 10.1038/nm.4236
   Poggi M, 2007, DIABETOLOGIA, V50, P1267, DOI 10.1007/s00125-007-0654-8
   Pomie C., 2016, INFLAMM CELL SIGNAL, V3, pe1074
   Roberfroid M, 2010, BRIT J NUTR, V104, pS1, DOI 10.1017/S0007114510003363
   Samuel BS, 2008, P NATL ACAD SCI USA, V105, P16767, DOI 10.1073/pnas.0808567105
   Sandler NG, 2012, NAT REV MICROBIOL, V10, P655, DOI 10.1038/nrmicro2848
   Sartor RB, 2008, GASTROENTEROLOGY, V134, P577, DOI 10.1053/j.gastro.2007.11.059
   Sender R, 2016, PLOS BIOL, V14, DOI 10.1371/journal.pbio.1002533
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Snedeker SM, 2012, ENVIRON HEALTH PERSP, V120, P332, DOI 10.1289/ehp.1104204
   Soyucen E, 2014, PEDIATR INT, V56, P336, DOI 10.1111/ped.12243
   Tremaroli V, 2012, NATURE, V489, P242, DOI 10.1038/nature11552
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Uronis JM, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0006026
   Uusitalo U, 2016, JAMA PEDIATR, V170, P20, DOI 10.1001/jamapediatrics.2015.2757
   Vehik K, 2011, DIABETES-METAB RES, V27, P3, DOI 10.1002/dmrr.1141
   Velmurugan G, 2013, TOXICOLOGY, V307, P103, DOI 10.1016/j.tox.2012.11.022
   Velmurugan G, 2017, GENOME BIOL, V18, DOI 10.1186/s13059-016-1134-6
   Vreugdenhil ACE, 2003, J IMMUNOL, V170, P1399, DOI 10.4049/jimmunol.170.3.1399
   Vrieze A, 2012, GASTROENTEROLOGY, V143, P913, DOI 10.1053/j.gastro.2012.06.031
   Wang L, 2016, SCI REP-UK, V6, DOI [10.1038/srep38380, 10.1038/srep33251, 10.1038/srep20004]
   Wang Q, 2006, J EXP MED, V203, P2853, DOI 10.1084/jem.20062008
   Weaver JR, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0142735
   WHO-World Health Organization, 2001, JOINT WHO FAO EXP CO
   Wolf KJ, 2014, J HISTOCHEM CYTOCHEM, V62, P237, DOI 10.1369/0022155413519650
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Wu W, 2016, EUR J IMMUNOL, V46, P1162, DOI 10.1002/eji.201546160
   Xiong T, 2020, SENSOR ACTUAT B-CHEM, V304, DOI [10.1126/scitranslmed.3009124, 10.1016/j.snb.2019.127310]
   Yadav H, 2007, NUTRITION, V23, P62, DOI 10.1016/j.nut.2006.09.002
   Zhang LM, 2015, ENVIRON HEALTH PERSP, V123, P679, DOI 10.1289/ehp.1409055
   Zhang Q, 2018, EXP BIOL MED, V243, P34, DOI 10.1177/1535370217743765
   Zhao SJ, 2019, CELL HOST MICROBE, V25, P656, DOI 10.1016/j.chom.2019.03.007
   Zuniga LA, 2010, J IMMUNOL, V185, P6947, DOI 10.4049/jimmunol.1001269
NR 85
TC 18
Z9 18
U1 2
U2 14
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 0962-9351
EI 1466-1861
J9 MEDIAT INFLAMM
JI Mediat. Inflamm.
PD DEC 30
PY 2019
VL 2019
AR 9367404
DI 10.1155/2019/9367404
PG 10
WC Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Immunology
GA KC6GZ
UT WOS:000507275000002
PM 32082078
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Qin, Q
   Chen, Y
   Li, YB
   Wei, J
   Zhou, XT
   Le, FY
   Hu, H
   Chen, TT
AF Qin, Qi
   Chen, Yan
   Li, Yongbo
   Wei, Jing
   Zhou, Xiaoting
   Le, Fuyin
   Hu, Hong
   Chen, Tingtao
TI Intestinal Microbiota Play an Important Role in the Treatment of Type I
   Diabetes in Mice With BefA Protein
SO FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
LA English
DT Article
DE T1DM; BefA protein; inflammation; intestinal barrier; intestinal
   microbiota
ID PERSPECTIVES; METFORMIN; BARRIER
AB More and more studies have shown that the intestinal microbiota is the main factor in the pathogenesis of type 1 diabetes mellitus (T1DM). Beta cell expansion factor A (BefA) is a protein expressed by intestinal microorganisms. It has been proven to promote the proliferation of beta-cells and has broad application prospects. However, as an intestinal protein, there have not been studies and reports on its application in diabetes and its mechanism of action. In this study, a T1DM model induced by multiple low-dose STZ (MLD-STZ) injections was established, and BefA protein was administered to explore its therapeutic effect in T1DM and the potential mechanism of intestinal microbiota. BefA protein significantly reduced the blood glucose, maintained the body weight, and improved the glucose tolerance of the mice. At the same time, the BefA protein significantly increased the expression of ZO-1, Occludin, and significantly reduced the expression of TLR-4, Myd88, and p-p65/p65. BefA protein significantly reduced the relative expression of pro-inflammatory cytokines IL-1 beta, IL-6 and TNF-alpha. In addition, our high-throughput sequencing shows for the first time that the good hypoglycemic effect of BefA protein is strongly related to the increase in the abundance of the beneficial gut bacteria Lactobacillus, Bifidobacterium and Oscillospria and the decrease in the abundance of the opportunistic pathogen Acinetobacter. Our group used animal models to verify the hypoglycemic effect of BefA protein, and first explored the potential mechanism of intestinal microbiota in BefA protein treatment.
C1 [Qin, Qi; Wei, Jing; Zhou, Xiaoting; Le, Fuyin; Chen, Tingtao] Nanchang Univ, Natl Engn Res Ctr Bioengn Drugs & Technol, Inst Translat Med, Nanchang, Jiangxi, Peoples R China.
   [Qin, Qi] Harbin Meihua Biotechnol Co Ltd, Res & Dev Ctr, Haerbin, Peoples R China.
   [Qin, Qi] Lanzhou Univ, Sch Life Sci, Lanzhou, Peoples R China.
   [Chen, Yan] Haifushan Hosp, Dept Dialysis, Weifang, Peoples R China.
   [Li, Yongbo] Haifushan Hosp, Dept Orthoped, Weifang, Peoples R China.
   [Hu, Hong] Nanchang Univ, Sch Life Sci, Nanchang, Jiangxi, Peoples R China.
   [Hu, Hong] Guangzhou Med Univ, Ctr Reprod Med, Qingyuan Peoplers Hosp, Affiliated Hosp 6, Qingyuan, Peoples R China.
C3 Nanchang University; Lanzhou University; Nanchang University; Guangzhou
   Medical University
RP Chen, TT (通讯作者)，Nanchang Univ, Natl Engn Res Ctr Bioengn Drugs & Technol, Inst Translat Med, Nanchang, Jiangxi, Peoples R China.; Hu, H (通讯作者)，Nanchang Univ, Sch Life Sci, Nanchang, Jiangxi, Peoples R China.; Hu, H (通讯作者)，Guangzhou Med Univ, Ctr Reprod Med, Qingyuan Peoplers Hosp, Affiliated Hosp 6, Qingyuan, Peoples R China.
EM 15770750681@163.com; chentingtao1984@163.com
RI wei, jing/GXA-1455-2022; zhou, xt/GWZ-9212-2022
FU National Natural Science Foundation of China [82060638]; Academic and
   technical leaders of major disciplines in Jiangxi Province
   [20194BCJ22032]; Double thousand plan of Jiangxi Province (high end
   Talents Project of scientific and technological innovation)
FX Funding This study was supported by the National Natural Science
   Foundation of China (Grant no. 82060638), Academic and technical leaders
   of major disciplines in Jiangxi Province (Grant no. 20194BCJ22032), and
   Double thousand plan of Jiangxi Province (high end Talents Project of
   scientific and technological innovation).
CR Allen Kate V, 2003, Endocr Pract, V9, P530
   Aoki K, 2010, INTERNAL MED, V49, P1085, DOI 10.2169/internalmedicine.49.3218
   Atkinson MA, 2001, LANCET, V358, P221, DOI 10.1016/S0140-6736(01)05415-0
   Beck RW, 2019, LANCET, V394, P1265, DOI 10.1016/S0140-6736(19)31142-0
   Cekanaviciute E, 2017, P NATL ACAD SCI USA, V114, P10713, DOI 10.1073/pnas.1711235114
   Chelakkot Chaithanya, 2018, Exp Mol Med, V50, P1, DOI 10.1038/s12276-018-0126-x
   Chen L, 2020, J PHARMACOL SCI, V143, P89, DOI 10.1016/j.jphs.2020.02.009
   Cho NH, 2018, DIABETES RES CLIN PR, V138, P271, DOI 10.1016/j.diabres.2018.02.023
   Clapham JC, 2020, METHODS MOL BIOL, V2076, P1, DOI 10.1007/978-1-4939-9882-1_1
   De Vedder F, 2018, P NATL ACAD SCI USA, V115, P6458, DOI 10.1073/pnas.1720017115
   Dean PG, 2017, BMJ-BRIT MED J, V357, DOI 10.1136/bmj.j1321
   DeFronzo R, 2016, METABOLISM, V65, P20, DOI 10.1016/j.metabol.2015.10.014
   Deshpande AD, 2008, PHYS THER, V88, P1254, DOI 10.2522/ptj.20080020
   DiMeglio LA, 2018, LANCET, V391, P2449, DOI 10.1016/S0140-6736(18)31320-5
   El-Khatib FH, 2017, LANCET, V389, P369, DOI 10.1016/S0140-6736(16)32567-3
   Gu YY, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-01682-2
   Halimi S, 2014, DIABETES METAB, V40, pS28, DOI 10.1016/S1262-3636(14)72693-X
   Heintz-Buschart A, 2017, NAT MICROBIOL, V2, DOI 10.1038/nmicrobiol.2016.180
   Hill JH, 2016, ELIFE, V5, DOI 10.7554/eLife.20145
   Ho LKH, 2020, GUT PATHOG, V12, DOI 10.1186/s13099-020-0346-1
   Kamal Ali D, 2006, Expert Opin Drug Saf, V5, P131, DOI 10.1517/14740338.5.1.131
   Katsarou Anastasia, 2017, Nat Rev Dis Primers, V3, P17016, DOI 10.1038/nrdp.2017.16
   Konikoff T, 2016, TRENDS MICROBIOL, V24, P523, DOI 10.1016/j.tim.2016.02.015
   Kung J, 2012, EXPERT OPIN DRUG SAF, V11, P565, DOI 10.1517/14740338.2012.691963
   Luissint AC, 2016, GASTROENTEROLOGY, V151, P616, DOI 10.1053/j.gastro.2016.07.008
   Maffi P, 2017, DEV OPHTHALMOL, V60, P1, DOI 10.1159/000459641
   McCreight LJ, 2016, DIABETOLOGIA, V59, P426, DOI 10.1007/s00125-015-3844-9
   Mehanna A, 2013, FUTURE MED CHEM, V5, P411, DOI [10.4155/FMC.13.13, 10.4155/fmc.13.13]
   Miani M, 2018, CELL METAB, V28, P557, DOI 10.1016/j.cmet.2018.06.012
   Needell JC, 2016, CURR DIABETES REP, V16, DOI 10.1007/s11892-016-0781-z
   Nunez M, 2019, DIABETES THER, V10, P375, DOI 10.1007/s13300-019-0563-0
   Riquelme E, 2019, CELL, V178, P795, DOI 10.1016/j.cell.2019.07.008
   Saeedi P, 2019, DIABETES RES CLIN PR, V157, DOI 10.1016/j.diabres.2019.107843
   Sakata N, 2012, EXP DIABETES RES, DOI 10.1155/2012/256707
   Shapiro AMJ, 2017, NAT REV ENDOCRINOL, V13, P268, DOI 10.1038/nrendo.2016.178
   Shin JH, 2018, EUR J NUTR, V57, P2081, DOI 10.1007/s00394-017-1481-4
   Simren M, 2018, GASTROENTEROLOGY, V155, P960, DOI 10.1053/j.gastro.2018.09.008
   Slifer ZM, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21030972
   Tilg H, 2020, NAT REV IMMUNOL, V20, P40, DOI 10.1038/s41577-019-0198-4
   Warnes H, 2018, DIABETES THER, V9, P1831, DOI 10.1007/s13300-018-0496-z
   Warshauer JT, 2020, CELL METAB, V31, P46, DOI 10.1016/j.cmet.2019.11.017
   Weisman A, 2017, LANCET DIABETES ENDO, V5, P501, DOI 10.1016/S2213-8587(17)30167-5
   Wu H, 2014, DISCOV MED, V17, P139
   Zheng PL, 2018, DIABETES-METAB RES, V34, DOI 10.1002/dmrr.3043
NR 44
TC 4
Z9 5
U1 9
U2 16
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2235-2988
J9 FRONT CELL INFECT MI
JI Front. Cell. Infect. Microbiol.
PD SEP 17
PY 2021
VL 11
AR 719542
DI 10.3389/fcimb.2021.719542
PG 10
WC Immunology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Microbiology
GA WV5XB
UT WOS:000717308700001
PM 34604109
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Feng, WH
   Wang, HD
   Zhang, PZ
   Gao, CX
   Tao, JX
   Ge, ZJ
   Zhu, DL
   Bi, Y
AF Feng, Wenhuan
   Wang, Hongdong
   Zhang, Pengzi
   Gao, Caixia
   Tao, Junxian
   Ge, Zhijuan
   Zhu, Dalong
   Bi, Yan
TI Modulation of gut microbiota contributes to curcumin-mediated
   attenuation of hepatic steatosis in rats
SO BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
LA English
DT Article
DE Curcumin; Hepatic steatosis; Gut microbiota
ID NONALCOHOLIC FATTY LIVER; INSULIN-RESISTANCE; OBESITY; DIET;
   INFLAMMATION; DISEASE; ACID; METFORMIN; RESPONSES; ECOLOGY
AB Background: Structural disruption of gut microbiota contributes to the development of non-alcoholic fatty liver disease (NAFLD) and modulating the gut microbiota represents a novel strategy for NAFLD prevention. Although previous studies have demonstrated that curcumin alleviates hepatic steatosis, its effect on the gut microbiota modulation has not been investigated.
   Methods: Next generation sequencing and multivariate analysis were utilized to evaluate the structural changes of gut microbiota in a NAFLD rat model induced by high fat-diet (HFD) feeding.
   Results: We found that curcumin attenuated hepatic ectopic fat deposition, improved intestinal barrier integrity, and alleviated metabolic endotoxemia in HFD-fed rats. More importantly, curcumin dramatically shifted the overall structure of the HFD-disrupted gut microbiota toward that of lean rats fed a normal diet and altered the gut microbial composition. The abundances of 110 operational taxonomic units (OTUs) were altered by curcumin. Seventy-six altered OTUs were significantly correlated with one or more hepatic steatosis associated parameters and designated 'functionally relevant phylotypes'. Thirty-six of the 47 functionally relevant OTUs that were positively correlated with hepatic steatosis associated parameters were reduced by curcumin.
   Conclusion: These results indicate that curcumin alleviates hepatic steatosis in part through stain-specific impacts on hepatic steatosis associated phylotypes of gut microbiota in rats.
   General significance: Compounds with antimicrobial activities should be further investigated as novel adjunctive therapies for NAFLD.
C1 [Feng, Wenhuan; Wang, Hongdong; Zhang, Pengzi; Gao, Caixia; Tao, Junxian; Ge, Zhijuan; Zhu, Dalong; Bi, Yan] Nanjing Univ, Sch Med, Drum Tower Hosp, Dept Endocrinol, 321 Zhongshan Rd, Nanjing 210008, Peoples R China.
C3 Nanjing University
RP Zhu, DL; Bi, Y (通讯作者)，Nanjing Univ, Sch Med, Drum Tower Hosp, Dept Endocrinol, 321 Zhongshan Rd, Nanjing 210008, Peoples R China.
EM zhudalong@nju.edu.cn; biyan@nju.edu.cn
RI Ge, zhijuan/GSJ-3114-2022; Bi, Yan/O-5153-2015
FU National Natural Science Foundation of China [81570736, 81270906,
   81570737, 81370947, 81500612, 81400832, 81200587, 81600637, 81600632,
   81300651]; Project of National Key Clinical Division; China Postdoctoral
   Science Foundation [2012M521050]; Jiangsu Province's Key Discipline of
   Medicine [XK201105]; Jiangsu Province's Key Provincial Talents Program
   [RC2011011]; Jiangsu Key Laboratory for Molecular Medicine [BM2007208];
   Jiangsu Province's Project of Standardized Diagnosis and Treatment of
   Key Diseases [2015604]; Key Project of Nanjing Clinical Medical Science;
   Nanjing Outstanding Youth Fund Projects [JQX13010]; Nanjing Science and
   Technology Development Projects [2013ZD005]; Medical and Health Research
   Projects of Nanjing Health Bureau [YKK14055, YKK11092]; Medical and
   Health Research Projects of Nanjing Health Bureau in Jiangsu Province of
   China [YKK14055, YKK11092]; Nanjing Science and Technology Development
   projects in Jiangsu Province of China [2013ZD005]; Fundamental Research
   Funds for the Central Universities [021414380208]
FX This study was supported by grants from the National Natural Science
   Foundation of China Grant Award (81570736, 81270906, 81570737, 81370947,
   81500612, 81400832, 81200587, 81600637, 81600632, and 81300651), the
   Project of National Key Clinical Division, the China Postdoctoral
   Science Foundation (2012M521050), Jiangsu Province's Key Discipline of
   Medicine (XK201105), Jiangsu Province's Key Provincial Talents Program
   (RC2011011), Jiangsu Key Laboratory for Molecular Medicine (BM2007208),
   Jiangsu Province's Project of Standardized Diagnosis and Treatment of
   Key Diseases (2015604), the Key Project of Nanjing Clinical Medical
   Science, Nanjing Outstanding Youth Fund Projects (JQX13010), Nanjing
   Science and Technology Development Projects (2013ZD005), and Medical and
   Health Research Projects of Nanjing Health Bureau (YKK14055, YKK11092).
   This work was also supported by Medical and Health Research Projects of
   Nanjing Health Bureau in Jiangsu Province of China (YKK14055, YKK11092),
   Nanjing Science and Technology Development projects in Jiangsu Province
   of China (2013ZD005), and Fundamental Research Funds for the Central
   Universities (021414380208).
CR Al-Sadi R, 2013, AM J PATHOL, V183, P1871, DOI 10.1016/j.ajpath.2013.09.001
   Al-Sadi RM, 2007, J IMMUNOL, V178, P4641, DOI 10.4049/jimmunol.178.7.4641
   Backhed F, 2004, P NATL ACAD SCI USA, V101, P15718, DOI 10.1073/pnas.0407076101
   Bashiardes S, 2016, MOL METAB, V5, P782, DOI 10.1016/j.molmet.2016.06.003
   Bhatia LS, 2012, EUR HEART J, V33, P1190, DOI 10.1093/eurheartj/ehr453
   Cabreiro F, 2013, CELL, V153, P228, DOI 10.1016/j.cell.2013.02.035
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   Chuengsamarn S, 2012, DIABETES CARE, V35, P2121, DOI 10.2337/dc12-0116
   De Filippo C, 2010, P NATL ACAD SCI USA, V107, P14691, DOI 10.1073/pnas.1005963107
   Dethlefsen L, 2007, NATURE, V449, P811, DOI 10.1038/nature06245
   Di Luccia B, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0134893
   El-Moselhy MA, 2011, FOOD CHEM TOXICOL, V49, P1129, DOI 10.1016/j.fct.2011.02.004
   Everard A, 2014, MBIO, V5, DOI 10.1128/mBio.01011-14
   Geurts L, 2011, FRONT MICROBIOL, V2, DOI 10.3389/fmicb.2011.00149
   Graessler J, 2013, PHARMACOGENOMICS J, V13, P514, DOI 10.1038/tpj.2012.43
   Keating SE, 2012, J HEPATOL, V57, P157, DOI 10.1016/j.jhep.2012.02.023
   Le Roy T, 2013, GUT, V62, P1787, DOI 10.1136/gutjnl-2012-303816
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Lee HY, 2006, BBA-MOL CELL BIOL L, V1761, P736, DOI 10.1016/j.bbalip.2006.05.007
   Lonardo A, 2016, HEPATOLOGY, V64, P1388, DOI 10.1002/hep.28584
   Luck H, 2015, CELL METAB, V21, P527, DOI 10.1016/j.cmet.2015.03.001
   Martin RCG, 2012, FOOD CHEM TOXICOL, V50, P227, DOI 10.1016/j.fct.2011.10.070
   Maslowski KM, 2009, NATURE, V461, P1282, DOI 10.1038/nature08530
   Midura-Kiela MT, 2012, AM J PHYSIOL-GASTR L, V302, pG85, DOI 10.1152/ajpgi.00275.2011
   Monteiro-Sepulveda M, 2015, CELL METAB, V22, P113, DOI 10.1016/j.cmet.2015.05.020
   Moschen AR, 2013, TRENDS ENDOCRIN MET, V24, P537, DOI 10.1016/j.tem.2013.05.009
   Park DY, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0059470
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Ravussin Y, 2012, OBESITY, V20, P738, DOI 10.1038/oby.2011.111
   Robinson CJ, 2010, MICROBIOL MOL BIOL R, V74, P453, DOI 10.1128/MMBR.00014-10
   Scheppach W, 2004, CURR OPIN CLIN NUTR, V7, P563, DOI 10.1097/00075197-200409000-00009
   Selma MV, 2016, FOOD FUNCT, V7, P1769, DOI [10.1039/C5FO01100K, 10.1039/c5fo01100k]
   Shao WJ, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0028784
   Sharma RA, 2007, ADV EXP MED BIOL, V595, P453
   Shi H, 2006, J CLIN INVEST, V116, P3015, DOI 10.1172/JCI28898
   Wang HD, 2015, J STEROID BIOCHEM, V154, P254, DOI 10.1016/j.jsbmb.2015.09.003
   Wang JJ, 2015, ISME J, V9, P1, DOI 10.1038/ismej.2014.99
   Weisberg SP, 2008, ENDOCRINOLOGY, V149, P3549, DOI 10.1210/en.2008-0262
   Xiao SM, 2014, FEMS MICROBIOL ECOL, V87, P357, DOI 10.1111/1574-6941.12228
   Xu J, 2015, ISME J, V9, P552, DOI 10.1038/ismej.2014.177
   Yekollu SK, 2011, DIABETES, V60, P2928, DOI 10.2337/db11-0275
   Zhang X, 2012, PLOS ONE, V7, DOI [10.1371/journal.pone.0042529, 10.1371/journal.pone.0035700]
NR 43
TC 80
Z9 84
U1 3
U2 58
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0304-4165
EI 1872-8006
J9 BBA-GEN SUBJECTS
JI Biochim. Biophys. Acta-Gen. Subj.
PD JUL
PY 2017
VL 1861
IS 7
BP 1801
EP 1812
DI 10.1016/j.bbagen.2017.03.017
PG 12
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA FA0WV
UT WOS:000405158300013
PM 28341485
DA 2023-06-08
ER

PT J
AU Shen, HR
   Xu, X
   Ye, D
   Li, XL
AF Shen, Hao-Ran
   Xu, Xiao
   Ye, Dan
   Li, Xue-Lian
TI Berberine Improves the Symptoms of DHEA-Induced PCOS Rats by Regulating
   Gut Microbiotas and Metabolites
SO GYNECOLOGIC AND OBSTETRIC INVESTIGATION
LA English
DT Article
DE Polycystic ovary syndrome; Insulin resistance; Gut microbiota; Berberine
ID POLYCYSTIC-OVARY-SYNDROME; INSULIN-RESISTANCE; WOMEN; GLUTAMINE;
   SUPPLEMENTATION; PREVALENCE; DYSBIOSIS; METFORMIN; ANXIETY; BRAIN
AB Objectives: The aim of this study was to investigate the effects of berberine on polycystic ovary syndrome (PCOS) with insulin resistance (IR). Design: This study performed 16S rRNA sequencing and metabolomic analysis on dehydroepiandrosterone (DHEA)-induced PCOS rats treated with berberine, focusing on the improvement of PCOS-IR by modifying gut microbiota and metabolism. Methods: Forty-two female Sprague Dawley rats were randomly divided into 4 experimental groups of 8 rats each (PCOS + HFD, PCOS + HFD + BBR, NCD + PCOS, and NCD + PCOS + BBR groups). Homeostasis model assessment of insulin resistance (HOMA-IR) index-related indicators and hormone level in serum were analyzed. 16S rRNA sequencing and metabolomic analysis were performed on DHEA-induced PCOS rats treated with berberine. In addition, the differential microbiotas and metabolites were screened. Also, enrichment analysis was carried out on the differential metabolites. Finally, we constructed a correlation network to analyze the correlation between differential microbiotas and metabolites. Results: Firmicutes and Bacteroidetes were changed at the phylum level, and Romboutsia, Bacteroides, and Clostridium_sensu_stricto_1 were changed at the genus level after berberine treatment. In addition, a total of 26 differential operational taxonomic units and 3 metabolites (glutamine, unsaturated acids [CH = CH], and glucose) between 2 groups were obtained. Moreover, these metabolites were mainly involved in type 2 diabetes mellitus, 2-component system, and ABC transporter Kyoto Encyclopedia of Genes and Genomes pathways. And, 3 microbiotas (Lachnospiraceae_NC2004_group, Flavonifractor, and Parasutterella) were regulated by glucose and glutamine. Limitations: The sample size involved in this study is relatively small. In addition, relevant experiments need to be performed to verify the obtained results from this study, and in-depth functional studies are needed. Conclusions: Berberine is effective in improving the pathological condition in PCOS by regulating the gut microbiotas and metabolites. This study will provide evidence for therapeutic efforts to treat PCOS-IR using berberine.
C1 [Shen, Hao-Ran; Xu, Xiao; Ye, Dan; Li, Xue-Lian] Fudan Univ, Obstet & Gynecol Hosp, Dept Gynecol, Shanghai, Peoples R China.
   [Li, Xue-Lian] Shanghai Key Lab Female Reprod Endocrine Related, Shanghai, Peoples R China.
C3 Fudan University
RP Shen, HR; Li, XL (通讯作者)，Fudan Univ, Obstet & Gynecol Hosp, Dept Gynecol, Shanghai, Peoples R China.; Li, XL (通讯作者)，Shanghai Key Lab Female Reprod Endocrine Related, Shanghai, Peoples R China.
EM alainshen@aliyun.com; xllifc@fudan.edu.cn
RI shen, hao/HGF-0551-2022
OI Xu, Xiao/0000-0001-9783-6776
FU Natural Science Foundation from the Science and Technology Commission of
   Shanghai Municipality [17ZR1403100]
FX This study was supported by the Natural Science Foundation from the
   Science and Technology Commission of Shanghai Municipality (Grant No.
   17ZR1403100 to Xue-Lian Li).
CR Azziz R, 2004, J CLIN ENDOCR METAB, V89, P2745, DOI 10.1210/jc.2003-032046
   Bargiota A, 2012, THER ADV ENDOCRINOL, V3, P27, DOI 10.1177/2042018812437355
   Bowe JE, 2014, J ENDOCRINOL, V222, pG13, DOI 10.1530/JOE-14-0182
   CHEN K, 1994, JPEN-PARENTER ENTER, V18, P167, DOI 10.1177/0148607194018002167
   Di Emidio G, 2020, CELLS-BASEL, V9, DOI 10.3390/cells9010209
   Diamanti-Kandarakis E, 1998, EUR J ENDOCRINOL, V138, P269, DOI 10.1530/eje.0.1380269
   Dragamestianos C, 2019, GYNECOL OBSTET INVES, V84, P35, DOI 10.1159/000491086
   Feng XJ, 2019, THERANOSTICS, V9, P1923, DOI 10.7150/thno.30787
   Foster JA, 2013, TRENDS NEUROSCI, V36, P305, DOI 10.1016/j.tins.2013.01.005
   Gonzalez F, 2012, STEROIDS, V77, P300, DOI 10.1016/j.steroids.2011.12.003
   Guo Y, 2016, PLASMONICS, V11, P11, DOI [10.1007/s11468-015-0008-1, 10.1371/journal.pone.0156323]
   Jiang XJ, 2020, GYNECOL OBSTET INVES, V85, P167, DOI 10.1159/000505452
   Karadeniz M, 2011, LIPIDS HEALTH DIS, V10, DOI 10.1186/1476-511X-10-193
   Kelley ST, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0146509
   Kim SN, 2019, GYNECOL OBSTET INVES, V84, P225, DOI 10.1159/000493131
   Lai H, 2014, BIOL REPROD, V91, DOI 10.1095/biolreprod.114.120063
   Li MF, 2018, EVID-BASED COMPL ALT, V2018, DOI 10.1155/2018/2532935
   Li R, 2013, HUM REPROD, V28, P2562, DOI 10.1093/humrep/det262
   Liu D, 2018, EXP CLIN ENDOCR DIAB, V126, P513, DOI 10.1055/s-0043-125066
   Mayer EA, 2011, NAT REV NEUROSCI, V12, P453, DOI 10.1038/nrn3071
   Meier RK, 2018, NURS CLIN N AM, V53, P407, DOI 10.1016/j.cnur.2018.04.008
   Mohammadi M, 2019, INT J PREVENTIVE MED, V10, DOI 10.4103/ijpvm.IJPVM_576_17
   Nemati A, 2019, DRUG DES DEV THER, V13, P4215, DOI 10.2147/DDDT.S218606
   Oram JF, 2001, J LIPID RES, V42, P1173
   Orostica L, 2020, REPROD SCI, V27, P290, DOI 10.1007/s43032-019-00026-3
   Putignani L, 2016, INFLAMM BOWEL DIS, V22, P487, DOI 10.1097/MIB.0000000000000602
   Qi YJ, 2021, GYNECOL OBSTET INVES, V86, P155, DOI 10.1159/000513671
   Raizel R, 2016, BRIT J NUTR, V116, P470, DOI 10.1017/S0007114516001999
   Shen HR, 2021, REPROD BIOL ENDOCRIN, V19, DOI 10.1186/s12958-020-00684-y
   Sir-Petermann T, 2005, NUTRITION, V21, P1160, DOI 10.1016/j.nut.2005.07.002
   Tan XR, 2016, CLIN INVEST MED, V39, pE120
   Tang WHW, 2019, NAT REV CARDIOL, V16, P137, DOI 10.1038/s41569-018-0108-7
   TAYLOR CE, 1989, ANNU REV PUBL HEALTH, V10, P221, DOI 10.1146/annurev.pu.10.050189.001253
   Tremellen K, 2012, MED HYPOTHESES, V79, P104, DOI 10.1016/j.mehy.2012.04.016
   Wang Y, 2017, METABOLISM, V70, P72, DOI 10.1016/j.metabol.2017.02.003
   Wong ML, 2016, MOL PSYCHIATR, V21, P797, DOI 10.1038/mp.2016.46
   Wu XK, 2016, FERTIL STERIL, V106, P757, DOI 10.1016/j.fertnstert.2016.05.022
   Yang KL, 2018, REPROD BIOL ENDOCRIN, V16, DOI 10.1186/s12958-018-0346-x
   Yang SH, 2020, GYNECOL OBSTET INVES, V85, P252, DOI 10.1159/000507441
   Zhang X, 2012, PLOS ONE, V7, DOI [10.1371/journal.pone.0040320, 10.1371/journal.pone.0042529]
   Zhang Y, 2016, TRIALS, V17, DOI 10.1186/s13063-016-1633-5
NR 41
TC 10
Z9 10
U1 1
U2 15
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0378-7346
EI 1423-002X
J9 GYNECOL OBSTET INVES
JI Gynecol.Obstet.Invest.
PD SEP
PY 2021
VL 86
IS 4
BP 388
EP 397
DI 10.1159/000518040
EA AUG 2021
PG 10
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA UT8JP
UT WOS:000686246400001
PM 34515131
OA hybrid
DA 2023-06-08
ER

PT J
AU Chu, NTR
   Chan, JCN
   Chow, E
AF Chu, Natural
   Chan, Juliana C. N.
   Chow, Elaine
TI Pharmacomicrobiomics in Western Medicine and Traditional Chinese
   Medicine in Type 2 Diabetes
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE medication; traditional Chinese medicine; diabetes; microbiota;
   Akkermansia
ID GUT MICROBIOTA; AKKERMANSIA-MUCINIPHILA; DOUBLE-BLIND; MULTI-OMICS;
   METFORMIN; ACARBOSE; DAPAGLIFLOZIN; INFLAMMATION; MODULATION; OBESITY
AB Pharmacomicrobiomics refers to the interactions between foreign compounds and the gut microbiome resulting in heterogeneous efficacy, side effects, and toxicity of the compound concerned. Glucose lowering drugs reduce blood glucose by modulating insulin secretion and its actions as well as redistributing energy disposal. Apart from genetic, ecological, and lifestyle factors, maintaining an equilibrium of the whole gut microbiome has been shown to improve human health. Microbial fingerprinting using faecal samples indicated an 'invisible phenotype' due to different compositions of microbiota which might orchestrate the interactions between patients' phenotypes and their responses to glucose-lowering drugs. In this article, we summarize the current evidence on differences in composition of gut microbiota between individuals with type 2 diabetes (T2D) and healthy individuals, the disruption of the balance of beneficial and pathogenic microbiota was shown in patients with T2D and how Western Medicine (WM) and Traditional Chinese Medicine (TCM) might re-shape the gut microbiota with benefits to the host immunity and metabolic health. We particularly highlighted the effects of both WM and TCM increase the relative abundance of health promoting bacteria, such as, Akkermansia muciniphila, Blautia, and Bifidobacterium adolescentis, and which have been implicated in type 2 diabetes (T2D). Several lines of evidence suggested that TCM might complement the efficacy of WM through alteration of microbiota which warrants further investigation in our pursuit of prevention and control of T2D.
C1 [Chu, Natural; Chan, Juliana C. N.; Chow, Elaine] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Med & Therapeut, Hong Kong, Peoples R China.
   [Chan, Juliana C. N.] Chinese Univ Hong Kong, Prince Wales Hosp, Li Ka Shing Inst Hlth Sci, Hong Kong, Peoples R China.
   [Chan, Juliana C. N.] Chinese Univ Hong Kong, Prince Wales Hosp, Hong Kong Inst Diabet & Obes, Hong Kong, Peoples R China.
   [Chan, Juliana C. N.; Chow, Elaine] Chinese Univ Hong Kong, Prince Wales Hosp, Phase Clin Trial Ctr 1, Hong Kong, Hong Kong, Peoples R China.
C3 Chinese University of Hong Kong; Prince of Wales Hospital; Chinese
   University of Hong Kong; Prince of Wales Hospital; Chinese University of
   Hong Kong; Prince of Wales Hospital; Chinese University of Hong Kong;
   Prince of Wales Hospital
RP Chow, E (通讯作者)，Chinese Univ Hong Kong, Prince Wales Hosp, Dept Med & Therapeut, Hong Kong, Peoples R China.; Chow, E (通讯作者)，Chinese Univ Hong Kong, Prince Wales Hosp, Phase Clin Trial Ctr 1, Hong Kong, Hong Kong, Peoples R China.
EM e.chow@cuhk.edu.hk
RI Chan, Juliana/B-7918-2016; Chow, Elaine/HJB-2197-2022
OI Chan, Juliana/0000-0003-1325-1194; Chow, Elaine/0000-0002-4147-3387;
   Chu, Natural/0000-0003-3678-6749
CR Ahmadi S, 2020, J GERONTOL A-BIOL, V75, pE9, DOI 10.1093/gerona/glaa056
   Baxter NT, 2019, MSPHERE, V4, DOI [10.1128/mSphere.00528-18, 10.1128/msphere.00528-18]
   Bolam DN, 2011, GUT MICROBES, V2, P86, DOI 10.4161/gmic.2.2.15232
   Bornstein S, 2017, ENDOCRINOLOGY, V158, P3369, DOI 10.1210/en.2017-00299
   Brandt A, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-43228-0
   Bronden A, 2018, DIABETES OBES METAB, V20, P1623, DOI 10.1111/dom.13272
   Burton Jeffrey H, 2015, J Diabetes Sci Technol, V9, P808, DOI 10.1177/1932296815577425
   Cao Y, 2019, J DIABETES RES, V2019, DOI 10.1155/2019/1872134
   Cernakova M, 2002, FOLIA MICROBIOL, V47, P375, DOI 10.1007/BF02818693
   Chan JCN, 2020, LANCET, V396, P2019, DOI 10.1016/S0140-6736(20)32374-6
   Chen PC, 2019, NUTRITION, V63-64, P51, DOI 10.1016/j.nut.2018.11.019
   Cho NH, 2018, DIABETES RES CLIN PR, V138, P271, DOI 10.1016/j.diabres.2018.02.023
   Chung E, 2020, NUTR RES, V77, P97, DOI 10.1016/j.nutres.2020.04.001
   Cui X, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19113634
   Dao MC, 2016, GUT, V65, P426, DOI 10.1136/gutjnl-2014-308778
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   [邓冠华 Deng Guanhua], 2014, [生态科学, Ecologic Science], V33, P851
   Dickson Iain, 2018, Nat Rev Gastroenterol Hepatol, V15, P68, DOI 10.1038/nrgastro.2017.187
   Duncan SH, 2007, APPL ENVIRON MICROB, V73, P1073, DOI 10.1128/AEM.02340-06
   Ejtahed HS, 2019, EUR J ENDOCRINOL, V180, P165, DOI [10.1530/EJE-18-0826, 10.1530/eje-18-0826]
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Flint HJ, 2012, GUT MICROBES, V3, P289, DOI 10.4161/gmic.19897
   Gaike AH, 2020, MSYSTEMS, V5, DOI 10.1128/mSystems.00578-19
   Gao K, 2018, PHARMACOL RES, V130, P93, DOI 10.1016/j.phrs.2018.01.011
   Gu YY, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-01682-2
   Gurung M, 2020, EBIOMEDICINE, V51, DOI 10.1016/j.ebiom.2019.11.051
   Harrison SA, 2021, NAT COMMUN, V12, DOI 10.1038/s41467-021-25701-5
   Hwang JT, 2009, NEW BIOTECHNOL, V26, P17, DOI 10.1016/j.nbt.2009.03.005
   Ji SQ, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00704
   Johnston R, 2017, HEALTH TECHNOL ASSES, V21, P1, DOI 10.3310/hta21020
   Keshavarzian A, 2015, MOVEMENT DISORD, V30, P1351, DOI 10.1002/mds.26307
   Lee DM, 2018, CARDIOVASC DIABETOL, V17, DOI 10.1186/s12933-018-0708-x
   Lee H, 2018, GUT MICROBES, V9, P155, DOI 10.1080/19490976.2017.1405209
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Lepercq Pascale, 2004, Microbial Ecology in Health and Disease, V16, P195, DOI 10.1080/08910600410033393
   Li WZ, 2020, WORLD J DIABETES, V11, P293, DOI 10.4239/wjd.v11.i7.293
   Liao XY, 2019, EBIOMEDICINE, V44, P665, DOI 10.1016/j.ebiom.2019.03.057
   Liu XM, 2021, GUT MICROBES, V13, DOI 10.1080/19490976.2021.1875796
   Liu Y, 2020, CELL METAB, V31, P77, DOI 10.1016/j.cmet.2019.11.001
   Lv ZQ, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.00191
   Lyu YF, 2019, LIFE SCI, V235, DOI 10.1016/j.lfs.2019.116818
   Machado MV, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17040481
   Magne F, 2020, NUTRIENTS, V12, DOI 10.3390/nu12051474
   Medina-Vera I, 2019, DIABETES METAB, V45, P122, DOI 10.1016/j.diabet.2018.09.004
   Motiani KK, 2020, MED SCI SPORT EXER, V52, P94, DOI 10.1249/MSS.0000000000002112
   Olivares M, 2018, DIABETOLOGIA, V61, P1838, DOI 10.1007/s00125-018-4647-6
   Palacios T, 2017, TRIALS, V18, DOI 10.1186/s13063-016-1762-x
   Pu S., 1999, CHIN TRADIT HERBAL D, V30, P373
   Ryan PM, 2020, CAN J DIABETES, V44, P146, DOI 10.1016/j.jcjd.2019.05.008
   Saad MJA, 2016, PHYSIOLOGY, V31, P283, DOI 10.1152/physiol.00041.2015
   Sanders ME, 2019, NAT REV GASTRO HEPAT, V16, P605, DOI 10.1038/s41575-019-0173-3
   Sedighi M, 2017, MICROB PATHOGENESIS, V111, P362, DOI 10.1016/j.micpath.2017.08.038
   Shang JJ, 2021, PEERJ, V9, DOI 10.7717/peerj.11128
   Shapiro H, 2018, J EXP MED, V215, P383, DOI 10.1084/jem.20171965
   Shin NR, 2020, AM J PHYSIOL-ENDOC M, V318, pE52, DOI 10.1152/ajpendo.00221.2019
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Smits MM, 2021, DIABETES METAB, V47, DOI 10.1016/j.diabet.2021.101223
   Su BL, 2015, J DIABETES, V7, P729, DOI 10.1111/1753-0407.12232
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Sun X, 2015, TRIALS, V16, DOI 10.1186/s13063-015-0990-9
   Takewaki F, 2021, NUTRIENTS, V13, DOI 10.3390/nu13062107
   Thingholm LB, 2019, CELL HOST MICROBE, V26, P252, DOI 10.1016/j.chom.2019.07.004
   Tong XL, 2018, MBIO, V9, DOI 10.1128/mBio.02392-17
   Turroni F, 2016, ISME J, V10, P1656, DOI 10.1038/ismej.2015.236
   Umirah F, 2021, DIABETES RES CLIN PR, V173, DOI 10.1016/j.diabres.2021.108689
   Vallianou NG, 2019, HORM-INT J ENDOCRINO, V18, P141, DOI 10.1007/s42000-019-00093-w
   Vamanu E, 2016, J MED FOOD, V19, P1188, DOI 10.1089/jmf.2016.0085
   van Bommel EJM, 2020, DIABETES METAB, V46, P164, DOI 10.1016/j.diabet.2019.11.005
   Wang JH, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00620
   Wang JH, 2017, GENES-BASEL, V8, DOI 10.3390/genes8100239
   Wang Zhang, 2018, Endocrinol Diabetes Metab, V1, pe00009, DOI 10.1002/edm2.9
   Weng JP, 2016, DIABETES-METAB RES, V32, P442, DOI 10.1002/dmrr.2827
   Wu H, 2020, CELL METAB, V32, P379, DOI 10.1016/j.cmet.2020.06.011
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Xu J, 2015, ISME J, V9, P552, DOI 10.1038/ismej.2014.177
   Xu XZ, 2020, GENOM PROTEOM BIOINF, V18, P721, DOI [10.1016/j.gpb.2019.09.0071672-0229, 10.1016/j.gpb.2019.09.007]
   Yan XF, 2016, J DIABETES RES, V2016, DOI 10.1155/2016/2093171
   Yu JK, 2021, FRONT CELL INFECT MI, V11, DOI 10.3389/fcimb.2021.698852
   Zhang JP, 2016, J DIABETES, V8, P559, DOI 10.1111/1753-0407.12337
   Zhang MC, 2019, BMJ OPEN DIAB RES CA, V7, DOI 10.1136/bmjdrc-2019-000717
   Zhang W, 2019, BIOMED PHARMACOTHER, V118, DOI 10.1016/j.biopha.2019.109131
   Zhang XY, 2017, DIABETES THER, V8, P293, DOI 10.1007/s13300-017-0226-y
   Zhang YX, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-16034-w
   Zhao L, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00233
   Zhao X, 2020, J DIABETES RES, V2020, DOI 10.1155/2020/8842651
   Zheng JL, 2018, J AGR FOOD CHEM, V66, P5821, DOI [10.1021/acsjafc.8b00829, 10.1021/acs.jafc.8b00829]
   Zhou WY, 2019, NATURE, V569, P663, DOI 10.1038/s41586-019-1236-x
NR 87
TC 4
Z9 4
U1 4
U2 10
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD MAY 4
PY 2022
VL 13
AR 857090
DI 10.3389/fendo.2022.857090
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 1J3EY
UT WOS:000797804200001
PM 35600606
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Bastos, RMC
   Rangel, EB
AF Bastos, Rosana M. C.
   Rangel, Erika B.
TI Gut microbiota-derived metabolites are novel targets for improving
   insulin resistance
SO WORLD JOURNAL OF DIABETES
LA English
DT Article
DE Insulin resistance; Gut microbiota; Metabolites; Host metabolism;
   Metabolic organs; Novel targets
ID DIABETES-MELLITUS; HYDROGEN-SULFIDE; OBESITY; METAGENOME; METFORMIN;
   SUCCINATE
AB The gut microbiota plays a key role in metabolic diseases. Gut-microbiota-derived metabolites are found in different dietary sources, including: Carbohydrate (acetate, propionate, butyrate, also known as short-chain fatty acids, as well as succinate); protein (hydrogen sulfide, indole, and phenylacetic acid); and lipids (resveratrol-, ferulic acid-, linoleic acid-, catechin- and berry-derived metabolites). Insulin resistance, which is a global pandemic metabolic disease that progresses to type 2 diabetes mellitus, can be directly targeted by these metabolites. Gut-microbiota-derived metabolites have broad effects locally and in distinct organs, in particular skeletal muscle, adipose tissue, and liver. These metabolites can modulate glucose metabolism, including the increase in glucose uptake and lipid oxidation in skeletal muscle, and decrease in lipogenesis and gluconeogenesis associated with lipid oxidation in the liver through activation of phosphatidylinositol 3-kinase - serine/threonine-protein kinase B and AMP-activated protein kinase. In adipose tissue, gut-microbiota-derived metabolites stimulate adipogenesis and thermogenesis, inhibit lipolysis, and attenuate inflammation. Importantly, an increase in energy expenditure and fat oxidation occurs in the whole body. Therefore, the therapeutic potential of current pharmacological and non-pharmacological approaches used to treat diabetes mellitus can be tested to target specific metabolites derived from intestinal bacteria, which may ultimately ameliorate the hyperglycemic burden.
C1 [Bastos, Rosana M. C.; Rangel, Erika B.] Hosp Israelita Albert Einstein, Albert Einstein 627,Bldg A,2SS, BR-05652001 Sao Paulo, SP, Brazil.
   [Rangel, Erika B.] Univ Fed Sao Paulo, Div Nephrol, BR-04023900 Sao Paulo, SP, Brazil.
C3 Hospital Israelita Albert Einstein; Universidade Federal de Sao Paulo
   (UNIFESP)
RP Rangel, EB (通讯作者)，Hosp Israelita Albert Einstein, Albert Einstein 627,Bldg A,2SS, BR-05652001 Sao Paulo, SP, Brazil.
EM erikabr@uol.com.br
RI Rangel, Erika B/H-3066-2013
OI Rangel, Erika B/0000-0003-0982-2484
FU Sao Paulo Research Foundation [2013/19560-6, 2017/23195-2]; EFSD
   (European Foundation for the Study of Diabetes)/Sanofi
FX Supported by Sao Paulo Research Foundation, No. 2013/19560-6 and No.
   2017/23195-2; and EFSD (European Foundation for the Study of
   Diabetes)/Sanofi (to Rangel EB).
CR Buret AG, 2022, ANTIOXID REDOX SIGN, V36, P211, DOI 10.1089/ars.2021.0004
   De Vadder F, 2016, CELL METAB, V24, P151, DOI 10.1016/j.cmet.2016.06.013
   Fan Y, 2021, NAT REV MICROBIOL, V19, P55, DOI 10.1038/s41579-020-0433-9
   Garcia-Martinez I, 2015, ANTIOXID REDOX SIGN, V23, P1305, DOI 10.1089/ars.2015.6383
   Herat LY, 2020, WORLD J GASTROENTERO, V26, DOI 10.3748/wjg.v26.i23.3225
   Hernandez MAG, 2019, NUTRIENTS, V11, DOI 10.3390/nu11081943
   Jang HR, 2021, WORLD J DIABETES, V12, DOI 10.4239/wjd.v12.i6.730
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kim J, 2019, FRONT MICROBIOL, V10, DOI 10.3389/fmicb.2019.01947
   Lee DM, 2018, CARDIOVASC DIABETOL, V17, DOI 10.1186/s12933-018-0708-x
   Madsen MSA, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-52103-x
   Markowiak-Kopec P, 2020, NUTRIENTS, V12, DOI 10.3390/nu12041107
   Nagata S, 2017, BENEF MICROBES, V8, P535, DOI 10.3920/BM2016.0170
   Nagpal R, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-30114-4
   Pal VK, 2018, IUBMB LIFE, V70, P393, DOI 10.1002/iub.1740
   Pichette J, 2017, ENDOCRINOLOGY, V158, P3416, DOI 10.1210/en.2017-00391
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Rodriguez-Nuevo A, 2019, CELL STRESS, V3, P195, DOI 10.15698/cst2019.06.190
   Serena C, 2018, ISME J, V12, P1642, DOI 10.1038/s41396-018-0068-2
   Szabo C, 2012, ANTIOXID REDOX SIGN, V17, P68, DOI 10.1089/ars.2011.4451
   Tonucci LB, 2017, CLIN NUTR, V36, P85, DOI 10.1016/j.clnu.2015.11.011
   Vallianou NG, 2019, HORM-INT J ENDOCRINO, V18, P141, DOI 10.1007/s42000-019-00093-w
   Vieira-Silva S, 2020, NATURE, V581, P310, DOI 10.1038/s41586-020-2269-x
   Wang H, 2020, FRONT CELL INFECT MI, V9, DOI 10.3389/fcimb.2019.00455
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Zhang Q, 2020, DIABET METAB SYND OB, V13, P5003, DOI 10.2147/DMSO.S286430
   Zhao CH, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0230200
   Zhao L, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00233
NR 28
TC 5
Z9 5
U1 5
U2 22
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
EI 1948-9358
J9 WORLD J DIABETES
JI World J. Diabetes
PD JAN 15
PY 2022
VL 13
IS 1
BP 65
EP 69
DI 10.4239/wjd.v13.i1.65
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA YP2OK
UT WOS:000748465800006
PM 35070060
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Lv, Y
   Zhao, X
   Guo, WY
   Gao, Y
   Yang, S
   Li, Z
   Wang, GX
AF Lv, You
   Zhao, Xue
   Guo, Weiying
   Gao, Ying
   Yang, Shuo
   Li, Zhuo
   Wang, Guixia
TI The Relationship between Frequently Used Glucose-Lowering Agents and Gut
   Microbiota in Type 2 Diabetes Mellitus
SO JOURNAL OF DIABETES RESEARCH
LA English
DT Review
ID CHAIN FATTY-ACIDS; PROTEIN-COUPLED RECEPTOR; GLUCAGON-LIKE PEPTIDE-1;
   CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; ACARBOSE TREATMENT;
   METFORMIN; ASSOCIATION; BUTYRATE; DIET
AB Metabolic diseases, especially diabetes mellitus, have become global health issues. The etiology of diabetes mellitus can be attributed to genetic and/or environmental factors. Current evidence suggests the association of gut microbiota with metabolic diseases. However, the effects of glucose-lowering agents on gut microbiota are poorly understood. Several studies revealed that these agents affect the composition and diversity of gut microbiota and consequently improve glucose metabolism and energy balance. Possible underlying mechanisms include affecting gene expression, lowering levels of inflammatory cytokines, and regulating the production of short-chain fatty acids. In addition, gut microbiota may alleviate adverse effects caused by glucose-lowering agents, and this can be especially beneficial in diabetic patients who experience severe gastrointestinal side effects and have to discontinue these agents. In conclusion, gut microbiota may provide a novel viewpoint for the treatment of patients with diabetes mellitus.
C1 [Lv, You; Zhao, Xue; Guo, Weiying; Gao, Ying; Yang, Shuo; Li, Zhuo; Wang, Guixia] Jilin Univ, Dept Endocrinol & Metab, Hosp 1, Changchun, Jilin, Peoples R China.
C3 Jilin University
RP Li, Z; Wang, GX (通讯作者)，Jilin Univ, Dept Endocrinol & Metab, Hosp 1, Changchun, Jilin, Peoples R China.
EM noble_zhuo@yahoo.ca; gwang168@jlu.edu.cn
OI Yang, Shuo/0000-0002-2579-8501
FU Fund for Science and Technology Development Plan of Jilin Province
   [20170623092TC-04]
FX The research was supported by the Fund for Science and Technology
   Development Plan of Jilin Province (20170623092TC-04) to You Lv.
CR Bailey CJ, 2008, DIABETOLOGIA, V51, P1552, DOI 10.1007/s00125-008-1053-5
   Blandino G, 2016, DIABETES METAB, V42, P303, DOI 10.1016/j.diabet.2016.04.004
   BONORA E, 1984, CURR MED RES OPIN, V9, P47, DOI 10.1185/03007998409109558
   Borch-Johnsen K, 1999, LANCET, V354, P617
   Boulange CL, 2016, GENOME MED, V8, DOI 10.1186/s13073-016-0303-2
   Burton Jeffrey H, 2015, J Diabetes Sci Technol, V9, P808, DOI 10.1177/1932296815577425
   Buse JB, 2016, DIABETES CARE, V39, P198, DOI 10.2337/dc15-0488
   Cabreiro F, 2013, CELL, V153, P228, DOI 10.1016/j.cell.2013.02.035
   Cani PD, 2007, DIABETOLOGIA, V50, P2374, DOI 10.1007/s00125-007-0791-0
   Chang CH, 2015, J CLIN ENDOCR METAB, V100, P1121, DOI 10.1210/jc.2014-2443
   Chen JM, 2014, J DIABETES RES, V2014, DOI 10.1155/2014/812628
   Chiasson JL, 2003, JAMA-J AM MED ASSOC, V290, P486, DOI 10.1001/jama.290.4.486
   Cox AJ, 2015, LANCET DIABETES ENDO, V3, P207, DOI 10.1016/S2213-8587(14)70134-2
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   den Besten G, 2013, J LIPID RES, V54, P2325, DOI 10.1194/jlr.R036012
   Duca FA, 2015, NAT MED, V21, P506, DOI 10.1038/nm.3787
   Dujic T, 2015, DIABETES, V64, P1786, DOI 10.2337/db14-1388
   Everard A, 2014, REV ENDOCR METAB DIS, V15, P189, DOI 10.1007/s11154-014-9288-6
   Florez H, 2010, POSTGRAD MED, V122, P112, DOI 10.3810/pgm.2010.03.2128
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Fullerton MD, 2013, NAT MED, V19, P1649, DOI 10.1038/nm.3372
   Grasset E, 2017, CELL METAB, V25, P1075, DOI 10.1016/j.cmet.2017.04.013
   Greenway F, 2014, BENEF MICROBES, V5, P29, DOI 10.3920/BM2012.0063
   Gu YY, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-01682-2
   Hanefeld M, 2004, EUR HEART J, V25, P10, DOI 10.1016/S0195-668X(03)00468-8
   Hartstra AV, 2015, DIABETES CARE, V38, P159, DOI 10.2337/dc14-0769
   Hur KY, 2015, J DIABETES INVEST, V6, P600, DOI 10.1111/jdi.12328
   Inzucchi SE, 2012, DIABETOLOGIA, V55, P1577, DOI 10.1007/s00125-012-2534-0
   Joshi SR, 2015, EXPERT OPIN PHARMACO, V16, P597, DOI 10.1517/14656566.2015.1009894
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Khan S, 2016, CHEM-BIOL INTERACT, V254, P124, DOI 10.1016/j.cbi.2016.06.007
   Le Chatelier E, 2013, NATURE, V500, P541, DOI 10.1038/nature12506
   Le Kim-Anne, 2012, Front Physiol, V3, P496, DOI 10.3389/fphys.2012.00496
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Lehmann A, 2016, AM J PHYSIOL-GASTR L, V310, pG887, DOI 10.1152/ajpgi.00068.2016
   Li YQ, 2014, INDIAN J MICROBIOL, V54, P12, DOI 10.1007/s12088-013-0410-3
   Liou AP, 2013, SCI TRANSL MED, V5, DOI 10.1126/scitranslmed.3005687
   Longo D., 2012, HARRISONS PRINCIPLES
   McCreight LJ, 2016, DIABETOLOGIA, V59, P426, DOI 10.1007/s00125-015-3844-9
   Mei XR, 2016, J AGR FOOD CHEM, V64, P7502, DOI 10.1021/acs.jafc.6b03474
   Miller RA, 2013, NATURE, V494, P256, DOI 10.1038/nature11808
   Nakagami T, 2004, DIABETOLOGIA, V47, P385, DOI 10.1007/s00125-004-1334-6
   Napolitano A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100778
   Nohr MK, 2013, ENDOCRINOLOGY, V154, P3552, DOI 10.1210/en.2013-1142
   Panwar H, 2014, EUR J NUTR, V53, P1465, DOI 10.1007/s00394-013-0649-9
   Perry RJ, 2016, NATURE, V534, P213, DOI 10.1038/nature18309
   Plovier H, 2017, NAT MED, V23, P107, DOI 10.1038/nm.4236
   Pound LD, 2015, DIABETES, V64, P4135, DOI 10.2337/db15-0788
   Powell DR, 2013, J PHARMACOL EXP THER, V345, P250, DOI 10.1124/jpet.113.203364
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Salonen A, 2014, ISME J, V8, P2218, DOI 10.1038/ismej.2014.63
   Samuel BS, 2008, P NATL ACAD SCI USA, V105, P16767, DOI 10.1073/pnas.0808567105
   Sasaki M, 2013, BMC GASTROENTEROL, V13, DOI 10.1186/1471-230X-13-81
   Sato J, 2014, DIABETES CARE, V37, P2343, DOI 10.2337/dc13-2817
   Sender R, 2016, PLOS BIOL, V14, DOI 10.1371/journal.pbio.1002533
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Standl E, 2014, CARDIOVASC DIABETOL, V13, DOI 10.1186/1475-2840-13-81
   Su BL, 2015, J DIABETES, V7, P729, DOI 10.1111/1753-0407.12232
   Suzuki Y, 2009, FEBS LETT, V583, P2157, DOI 10.1016/j.febslet.2009.05.052
   Tan J, 2014, ADV IMMUNOL, V121, P91, DOI 10.1016/B978-0-12-800100-4.00003-9
   Tian PJ, 2016, FOOD FUNCT, V7, P3789, DOI [10.1039/c6fo00831c, 10.1039/C6FO00831C]
   Tolhurst G, 2012, DIABETES, V61, P364, DOI 10.2337/db11-1019
   Weaver GA, 1997, J NUTR, V127, P717, DOI 10.1093/jn/127.5.717
   Wickens KL, 2017, BRIT J NUTR, V117, P804, DOI [10.1017/S0007114517000289, 10.1017/s0007114517000289]
   Wolever TMS, 2000, BRIT J NUTR, V84, P57
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Xu PF, 2017, BBA-GEN SUBJECTS, V1861, P2690, DOI 10.1016/j.bbagen.2017.07.013
   Yan XF, 2016, J DIABETES RES, V2016, DOI 10.1155/2016/2093171
   Yang M, 2017, AM J PHYSIOL-GASTR L, V312, pG367, DOI 10.1152/ajpgi.00232.2016
   Yang WY, 2014, LANCET DIABETES ENDO, V2, P46, DOI 10.1016/S2213-8587(13)70021-4
   Zhang Q, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0184735
   Zhang XY, 2017, DIABETES THER, V8, P293, DOI 10.1007/s13300-017-0226-y
   Zhang XQ, 2015, SCI REP-UK, V5, DOI 10.1038/srep10737
NR 73
TC 13
Z9 15
U1 1
U2 15
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6745
EI 2314-6753
J9 J DIABETES RES
JI J. Diabetes Res.
PY 2018
VL 2018
AR 1890978
DI 10.1155/2018/1890978
PG 7
WC Endocrinology & Metabolism; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Research & Experimental Medicine
GA GG6BB
UT WOS:000432779700001
PM 29854817
OA gold, Green Submitted, Green Published
DA 2023-06-08
ER

PT J
AU Bulut, O
   Kilic, G
   Dominguez-Andres, J
AF Bulut, Ozlem
   Kilic, Gizem
   Dominguez-Andres, Jorge
TI Immune Memory in Aging: a Wide Perspective Covering Microbiota, Brain,
   Metabolism, and Epigenetics
SO CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
LA English
DT Article
DE Immune memory; Immunosenescence; Aging; Trained Immunity; Metabolism;
   Microbiota
ID HEMATOPOIETIC STEM-CELLS; AGE-RELATED-CHANGES; REGULATORY T-CELLS;
   B-CELLS; CALORIC RESTRICTION; GUT MICROBIOTA; DNA METHYLATION;
   INTESTINAL MICROBIOTA; PHYSICAL-ACTIVITY; MOUSE MODEL
AB Non-specific innate and antigen-specific adaptive immunological memories are vital evolutionary adaptations that confer long-lasting protection against a wide range of pathogens. Adaptive memory is established by memory T and B lymphocytes following the recognition of an antigen. On the other hand, innate immune memory, also called trained immunity, is imprinted in innate cells such as macrophages and natural killer cells through epigenetic and metabolic reprogramming. However, these mechanisms of memory generation and maintenance are compromised as organisms age. Almost all immune cell types, both mature cells and their progenitors, go through age-related changes concerning numbers and functions. The aging immune system renders the elderly highly susceptible to infections and incapable of mounting a proper immune response upon vaccinations. Besides the increased infectious burden, older individuals also have heightened risks of metabolic and neurodegenerative diseases, which have an immunological component. This review discusses how immune function, particularly the establishment and maintenance of innate and adaptive immunological memory, regulates and is regulated by epigenetics, metabolic processes, gut microbiota, and the central nervous system throughout life, with a focus on old age. We explain in-depth how epigenetics and cellular metabolism impact immune cell function and contribute or resist the aging process. Microbiota is intimately linked with the immune system of the human host, and therefore, plays an important role in immunological memory during both homeostasis and aging. The brain, which is not an immune-isolated organ despite former opinion, interacts with the peripheral immune cells, and the aging of both systems influences the health of each other. With all these in mind, we aimed to present a comprehensive view of the aging immune system and its consequences, especially in terms of immunological memory. The review also details the mechanisms of promising anti-aging interventions and highlights a few, namely, caloric restriction, physical exercise, metformin, and resveratrol, that impact multiple facets of the aging process, including the regulation of innate and adaptive immune memory. We propose that understanding aging as a complex phenomenon, with the immune system at the center role interacting with all the other tissues and systems, would allow for more effective anti-aging strategies.
C1 [Bulut, Ozlem; Kilic, Gizem; Dominguez-Andres, Jorge] Radboud Univ Nijmegen Med Ctr, Dept Internal Med, Geert Grootepl Zuid 8, NL-6525 GA Nijmegen, Netherlands.
   [Bulut, Ozlem; Kilic, Gizem; Dominguez-Andres, Jorge] Radboud Inst Mol Life Sci RIMLS, Nijmegen, Netherlands.
C3 Radboud University Nijmegen
RP Dominguez-Andres, J (通讯作者)，Radboud Univ Nijmegen Med Ctr, Dept Internal Med, Geert Grootepl Zuid 8, NL-6525 GA Nijmegen, Netherlands.; Dominguez-Andres, J (通讯作者)，Radboud Inst Mol Life Sci RIMLS, Nijmegen, Netherlands.
EM Jorge.DominguezAndres@radboudumc.nl
RI Dominguez-Andres, Jorge/S-6211-2017; Kilic, Gizem/AAC-8866-2019
OI Dominguez-Andres, Jorge/0000-0002-9091-1961; Kilic,
   Gizem/0000-0002-8251-1909
CR Aaby P, 2010, BMJ-BRIT MED J, V341, DOI 10.1136/bmj.c6495
   Ademokun A, 2010, BIOGERONTOLOGY, V11, P125, DOI 10.1007/s10522-009-9256-9
   Ahlskog JE, 2011, MAYO CLIN PROC, V86, P876, DOI 10.4065/mcp.2011.0252
   Ahmadi S, 2020, J GERONTOL A-BIOL, V75, pE9, DOI 10.1093/gerona/glaa056
   Akatsu H, 2013, JPEN-PARENTER ENTER, V37, P631, DOI 10.1177/0148607112467819
   Akkaya M, 2020, NAT REV IMMUNOL, V20, P229, DOI 10.1038/s41577-019-0244-2
   Alam MS, 2021, FRONT IMMUNOL, V12, DOI 10.3389/fimmu.2021.672353
   Ale EC, 2021, FRONT MICROBIOL, V12, DOI 10.3389/fmicb.2021.631254
   Alfa MJ, 2018, CLIN NUTR, V37, P797, DOI 10.1016/j.clnu.2017.03.025
   Almanzar G, 2005, J VIROL, V79, P3675, DOI 10.1128/JVI.79.6.3675-3683.2005
   Alter G, 2018, SEMIN IMMUNOL, V39, P102, DOI 10.1016/j.smim.2018.05.003
   Andrew D, 2002, EXP GERONTOL, V37, P455, DOI 10.1016/S0531-5565(01)00213-3
   Ansaldo E, 2019, SCIENCE, V364, P1179, DOI 10.1126/science.aaw7479
   Arts RJW, 2016, CELL METAB, V24, P807, DOI 10.1016/j.cmet.2016.10.008
   Arts RJW, 2016, CELL REP, V17, P2562, DOI 10.1016/j.celrep.2016.11.011
   Badal VD, 2020, NUTRIENTS, V12, DOI 10.3390/nu12123759
   Baek H, 2016, ONCOTARGET, V7, P69347, DOI 10.18632/oncotarget.12469
   Balyan R, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21217972
   Banerjee R, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0002740
   Barnes P, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003248
   Baron R, 2008, FASEB J, V22, P2843, DOI 10.1096/fj.08-105866
   Barrientos RM, 2015, NEUROSCIENCE, V309, P84, DOI 10.1016/j.neuroscience.2015.03.007
   Baruch K, 2013, BRAIN BEHAV IMMUN, V34, P11, DOI 10.1016/j.bbi.2013.04.002
   Barwick BG, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-018-04234-4
   Baur JA, 2006, NATURE, V444, P337, DOI 10.1038/nature05354
   Baur JA, 2006, NAT REV DRUG DISCOV, V5, P493, DOI 10.1038/nrd2060
   Beck K, 2009, J EXP MED, V206, P2271, DOI 10.1084/jem.20090756
   Beers DR, 2008, P NATL ACAD SCI USA, V105, P15558, DOI 10.1073/pnas.0807419105
   Beers DR, 2011, BRAIN, V134, P1293, DOI 10.1093/brain/awr074
   Bekkering S, 2018, CELL, V172, P135, DOI 10.1016/j.cell.2017.11.025
   Bekkering S, 2016, CLIN VACCINE IMMUNOL, V23, P926, DOI 10.1128/CVI.00349-16
   Biragyn A, 2018, LANCET ONCOL, V19, pE295, DOI 10.1016/S1470-2045(18)30095-0
   Blomberg BB, 2013, IMMUNOL RES, V57, P354, DOI 10.1007/s12026-013-8440-9
   Bocklandt S, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0014821
   Bodogai M, 2018, SCI TRANSL MED, V10, DOI 10.1126/scitranslmed.aat4271
   Boge T, 2009, VACCINE, V27, P5677, DOI 10.1016/j.vaccine.2009.06.094
   Bollati V, 2009, MECH AGEING DEV, V130, P234, DOI 10.1016/j.mad.2008.12.003
   Boothby M, 2017, IMMUNITY, V46, P743, DOI 10.1016/j.immuni.2017.04.009
   Bosch M, 2012, NUTR HOSP, V27, P504, DOI [10.1590/S0212-16112012000200023, 10.3305/nh.2012.27.2.5519]
   Briceno O, 2016, AGING CELL, V15, P14, DOI 10.1111/acel.12384
   Bridgeman SC, 2018, DIABETES OBES METAB, V20, P1553, DOI 10.1111/dom.13262
   Brochard V, 2009, J CLIN INVEST, V119, P182, DOI 10.1172/JCI36470
   Broske AM, 2009, NAT GENET, V41, P1207, DOI 10.1038/ng.463
   Brown RL, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-01803-x
   Bruce-Keller AJ, 1999, ANN NEUROL, V45, P8, DOI 10.1002/1531-8249(199901)45:1<8::AID-ART4>3.0.CO;2-V
   Buck MD, 2016, CELL, V166, P63, DOI 10.1016/j.cell.2016.05.035
   Bulut O, 2020, INT IMMUNOL, V32, P741, DOI 10.1093/intimm/dxaa052
   Bunout D, 2002, JPEN-PARENTER ENTER, V26, P372, DOI 10.1177/0148607102026006372
   Butovsky Oleg, 2001, FASEB Journal, V15, P1065
   Cancro MP, 2020, ANNU REV IMMUNOL, V38, P315, DOI 10.1146/annurev-immunol-092419-031130
   Caro-Maldonado A, 2014, J IMMUNOL, V192, P3626, DOI 10.4049/jimmunol.1302062
   Caserta MT, 2009, INT REV NEUROBIOL, V84, P1, DOI 10.1016/S0074-7742(09)00401-2
   Catera M, 2016, ONCOTARGET, V7, P7455, DOI 10.18632/oncotarget.7059
   Cerutti A, 2013, NAT REV IMMUNOL, V13, P118, DOI 10.1038/nri3383
   Chang CH, 2013, CELL, V153, P1239, DOI 10.1016/j.cell.2013.05.016
   Chen M, 2015, J IMMUNOL, V194, P2607, DOI 10.4049/jimmunol.1403001
   Chen M, 2014, NAT MED, V20, P507, DOI 10.1038/nm.3521
   Chen SJ, 2012, IMMUN AGEING, V9, DOI 10.1186/1742-4933-9-18
   Cheng SC, 2014, SCIENCE, V345, P1579, DOI 10.1126/science.1250684
   Cheung P, 2018, CELL, V173, P1385, DOI 10.1016/j.cell.2018.03.079
   Chiu IM, 2008, P NATL ACAD SCI USA, V105, P17913, DOI 10.1073/pnas.0804610105
   Choi SC, 2020, EXP MOL MED, V52, P348, DOI 10.1038/s12276-020-0392-2
   Cianci R, 2020, VACCINES-BASEL, V8, DOI 10.3390/vaccines8040636
   Cicero AFG, 2021, EUR J NUTR, V60, P655, DOI 10.1007/s00394-020-02271-8
   Cirovic B, 2020, CELL HOST MICROBE, V28, P322, DOI 10.1016/j.chom.2020.05.014
   Claesson MJ, 2012, NATURE, V488, P178, DOI 10.1038/nature11319
   Claesson MJ, 2011, P NATL ACAD SCI USA, V108, P4586, DOI 10.1073/pnas.1000097107
   Clarke AJ, 2018, J EXP MED, V215, P399, DOI 10.1084/jem.20170771
   Clarke TB, 2010, NAT MED, V16, P228, DOI 10.1038/nm.2087
   CML ND, 2017, LEHNINGER PRINCIPLES
   Colman RJ, 2014, NAT COMMUN, V5, DOI 10.1038/ncomms4557
   Colman RJ, 2009, SCIENCE, V325, P201, DOI 10.1126/science.1173635
   Cong YZ, 2009, P NATL ACAD SCI USA, V106, P19256, DOI 10.1073/pnas.0812681106
   Damoulari C, 2021, ACTIVATE 2 DOUBLE BL
   Das J, 2019, EPIGENETICS-US, V14, P589, DOI 10.1080/15592294.2019.1603963
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   de Sousa CV, 2017, SPORTS MED, V47, P277, DOI 10.1007/s40279-016-0566-1
   Deczkowska A, 2018, J EXP MED, V215, P2702, DOI 10.1084/jem.20181737
   den Braber I, 2012, IMMUNITY, V36, P288, DOI 10.1016/j.immuni.2012.02.006
   Derhovanessian E, 2014, J IMMUNOL, V193, P3624, DOI 10.4049/jimmunol.1303361
   Di Benedetto S, 2015, BIOGERONTOLOGY, V16, P631, DOI 10.1007/s10522-015-9563-2
   Docherty JJ, 2005, ANTIVIR RES, V67, P155, DOI 10.1016/j.antiviral.2005.06.008
   Docherty JJ, 2004, ANTIVIR RES, V61, P19, DOI 10.1016/j.antiviral.2003.07.001
   Donnelly RP, 2015, MOL IMMUNOL, V68, P513, DOI 10.1016/j.molimm.2015.07.034
   Donohoe DR, 2012, J CELL PHYSIOL, V227, P3169, DOI 10.1002/jcp.24054
   Dou YL, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0121258
   Dozmorov MG, 2017, EPIGENOMICS-UK, V9, P429, DOI 10.2217/epi-2016-0143
   Dozmorov MG, 2015, EPIGENETICS-US, V10, P484, DOI 10.1080/15592294.2015.1040619
   Duggal NA, 2018, AGING CELL, V17, DOI 10.1111/acel.12750
   Dunn-Walters DK, 2020, INTERD T GERONT GERI, V43, P56, DOI 10.1159/000504479
   Duran-Ferrer M, 2020, NAT CANCER, V1, P1066, DOI 10.1038/s43018-020-00131-2
   Ekdahl CT, 2003, P NATL ACAD SCI USA, V100, P13632, DOI 10.1073/pnas.2234031100
   Enani S, 2018, CLIN NUTR, V37, P443, DOI 10.1016/j.clnu.2017.01.011
   Ersching J, 2017, IMMUNITY, V46, P1045, DOI 10.1016/j.immuni.2017.06.005
   Fahy GM, 2019, AGING CELL, V18, DOI 10.1111/acel.13028
   Ferencz B, 2014, PSYCHOL AGING, V29, P440, DOI 10.1037/a0035465
   Finamore A, 2019, NUTRITION, V63-64, P184, DOI 10.1016/j.nut.2019.02.005
   Flachsbart F, 2006, EXP GERONTOL, V41, P98, DOI 10.1016/j.exger.2005.09.008
   Franceschi C, 2018, NAT REV ENDOCRINOL, V14, P576, DOI 10.1038/s41574-018-0059-4
   Frasca D, 2004, EXP GERONTOL, V39, P481, DOI 10.1016/j.exger.2003.09.027
   Frasca D, 2003, FRONT BIOSCI, V8, pA110, DOI 10.2741/1059
   Frasca D, 2020, IMMUN AGEING, V17, DOI 10.1186/s12979-020-00210-z
   Frasca D, 2020, CELL IMMUNOL, V348, DOI 10.1016/j.cellimm.2019.103994
   Frasca D, 2017, EXP GERONTOL, V87, P113, DOI 10.1016/j.exger.2016.12.001
   Frasca D, 2016, OBESITY, V24, P615, DOI 10.1002/oby.21383
   Frasca D, 2011, AGEING RES REV, V10, P330, DOI 10.1016/j.arr.2010.08.004
   Fritzsching B, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0017988
   Fuentes S, 2021, LANCET HEALTH LONGEV, V2, pE13, DOI 10.1016/S2666-7568(20)30034-9
   Furman D, 2015, SCI TRANSL MED, V7, DOI 10.1126/scitranslmed.aaa2293
   Gardner EM, 2005, J GERONTOL A-BIOL, V60, P688, DOI 10.1093/gerona/60.6.688
   Garg SK, 2008, J IMMUNOL, V180, P3866, DOI 10.4049/jimmunol.180.6.3866
   Gattinoni L, 2011, NAT MED, V17, P1290, DOI 10.1038/nm.2446
   Germain RN, 2002, NAT REV IMMUNOL, V2, P309, DOI 10.1038/nri798
   Giamarellos-Bourboulis EJ, 2020, CELL, V183, P315, DOI 10.1016/j.cell.2020.08.051
   Gibson KL, 2009, AGING CELL, V8, P18, DOI 10.1111/j.1474-9726.2008.00443.x
   Gil A, 2015, J VIROL, V89, P4102, DOI 10.1128/JVI.03020-14
   Ginhoux F, 2010, SCIENCE, V330, P841, DOI 10.1126/science.1194637
   Gleeson M, 2011, NAT REV IMMUNOL, V11, P607, DOI 10.1038/nri3041
   Gleyzer N, 2005, MOL CELL BIOL, V25, P1354, DOI 10.1128/MCB.25.4.1354-1366.2005
   Gofrit ON, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0224433
   Goldberg EL, 2015, AGING CELL, V14, P130, DOI 10.1111/acel.12280
   Gomez I, 2004, EXP GERONTOL, V39, P597, DOI 10.1016/j.exger.2003.11.018
   Gordon CL, 2017, J EXP MED, V214, P651, DOI 10.1084/jem.20160758
   Gorelik G, 2007, J IMMUNOL, V179, P5553, DOI 10.4049/jimmunol.179.8.5553
   Goronzy JJ, 2017, IMMUNITY, V46, P364, DOI 10.1016/j.immuni.2017.03.010
   Gourbal B, 2018, IMMUNOL REV, V283, P21, DOI 10.1111/imr.12647
   Gourley TS, 2004, SEMIN IMMUNOL, V16, P323, DOI 10.1016/j.smim.2004.08.013
   Graff J, 2013, NAT REV NEUROSCI, V14, P97, DOI 10.1038/nrn3427
   Gubser PM, 2013, NAT IMMUNOL, V14, P1064, DOI 10.1038/ni.2687
   Guo J, 2015, FRONT AGING NEUROSCI, V7, DOI 10.3389/fnagi.2015.00213
   Hadad N, 2018, NEUROBIOL AGING, V67, P53, DOI 10.1016/j.neurobiolaging.2018.03.009
   Hagen M, 2020, GERONTOLOGY, V66, P105, DOI 10.1159/000501963
   Hahn, 2019, B CELLS GENERATION A, P101, DOI [10.1016/C2015-0-06776-4, DOI 10.1016/C2015-0-06776-4]
   Hamada A, 2019, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.03225
   Hamer M, 2009, PSYCHOL MED, V39, P3, DOI 10.1017/S0033291708003681
   Hannum G, 2013, MOL CELL, V49, P359, DOI 10.1016/j.molcel.2012.10.016
   Hao Y, 2011, BLOOD, V118, P1294, DOI 10.1182/blood-2011-01-330530
   Hapfelmeier S, 2010, SCIENCE, V328, P1705, DOI 10.1126/science.1188454
   Heldt SA, 2007, MOL PSYCHIATR, V12, P656, DOI 10.1038/sj.mp.4001957
   Heng Y, 2021, J NEUROINFLAMM, V18, DOI 10.1186/s12974-021-02103-4
   Henson SM, 2014, J CLIN INVEST, V124, P4004, DOI 10.1172/JCI75051
   Hoffman W, 2016, CLIN J AM SOC NEPHRO, V11, P137, DOI 10.2215/CJN.09430915
   Hohlfeld R, 2006, NEUROL SCI, V27, pS1, DOI 10.1007/s10072-006-0537-7
   Hole CR, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-10486-5
   Horvath S, 2013, GENOME BIOL, V14, DOI 10.1186/gb-2013-14-10-r115
   Hou YJ, 2019, NAT REV NEUROL, V15, P565, DOI 10.1038/s41582-019-0244-7
   Houtkooper RH, 2012, NAT REV MOL CELL BIO, V13, P225, DOI 10.1038/nrm3293
   Howard WA, 2006, REJUV RES, V9, P117, DOI 10.1089/rej.2006.9.117
   Howitz KT, 2003, NATURE, V425, P191, DOI 10.1038/nature01960
   Hwangbo DS, 2020, NUTRIENTS, V12, DOI 10.3390/nu12041194
   Hyun DH, 2006, P NATL ACAD SCI USA, V103, P19908, DOI 10.1073/pnas.0608008103
   Jahng JW, 2007, BRAIN RES, V1150, P100, DOI 10.1016/j.brainres.2007.02.080
   Jamieson BD, 1999, IMMUNITY, V10, P569, DOI 10.1016/S1074-7613(00)80056-4
   Jamshidian A, 2013, J NEUROIMMUNOL, V262, P106, DOI 10.1016/j.jneuroim.2013.06.007
   Jang KJ, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms7750
   Jasiulionis MG, 2018, FRONT IMMUNOL, V9, DOI 10.3389/fimmu.2018.00197
   Jellusova J, 2016, CRIT REV BIOCHEM MOL, V51, P359, DOI 10.1080/10409238.2016.1215288
   Jeng MY, 2018, J EXP MED, V215, P51, DOI 10.1084/jem.20161066
   Jenks SA, 2018, IMMUNITY, V49, P725, DOI 10.1016/j.immuni.2018.08.015
   Jiang CM, 2017, J ALZHEIMERS DIS, V58, P1, DOI 10.3233/JAD-161141
   Jimenez-Gomez Y, 2013, CELL METAB, V18, P533, DOI 10.1016/j.cmet.2013.09.004
   Jones DD, 2016, J CLIN INVEST, V126, P4250, DOI 10.1172/JCI86504
   Kannan S, 2016, ONCOTARGET, V7, P13340, DOI 10.18632/oncotarget.7958
   Kaufmann E, 2018, CELL, V172, P176, DOI 10.1016/j.cell.2017.12.031
   Keating ST, 2020, J MOL MED, V98, P819, DOI 10.1007/s00109-020-01915-w
   Khosravi A, 2014, CELL HOST MICROBE, V15, P374, DOI 10.1016/j.chom.2014.02.006
   Kleinnijenhuis J, 2012, P NATL ACAD SCI USA, V109, P17537, DOI 10.1073/pnas.1202870109
   Klinger D, 2021, VACCINES-BASEL, V9, DOI 10.3390/vaccines9050491
   Koeken VACM, 2020, J CLIN INVEST, V130, P5591, DOI 10.1172/JCI133935
   Koeth RA, 2013, NAT MED, V19, P576, DOI 10.1038/nm.3145
   Kogut I, 2012, SEMIN IMMUNOL, V24, P342, DOI 10.1016/j.smim.2012.04.004
   Koohy H, 2018, GENOME BIOL, V19, DOI 10.1186/s13059-018-1489-y
   Kozisek ME, 2008, PHARMACOL THERAPEUT, V117, P30, DOI 10.1016/j.pharmthera.2007.07.001
   Kristic J, 2014, J GERONTOL A-BIOL, V69, P779, DOI 10.1093/gerona/glt190
   Kulkarni AS, 2020, CELL METAB, V32, P15, DOI 10.1016/j.cmet.2020.04.001
   Kumar BV, 2018, IMMUNITY, V48, P202, DOI 10.1016/j.immuni.2018.01.007
   Kunis G, 2013, BRAIN, V136, P3427, DOI 10.1093/brain/awt259
   Kurupati RK, 2019, AGING-US, V11, P4367, DOI 10.18632/aging.102058
   Kuwahara M, 2014, NAT COMMUN, V5, DOI 10.1038/ncomms4555
   Kverneland AH, 2016, CYTOM PART A, V89A, P543, DOI 10.1002/cyto.a.22855
   Lai AY, 2013, GENOME RES, V23, P2030, DOI 10.1101/gr.155473.113
   Lam WY, 2016, IMMUNITY, V45, P60, DOI 10.1016/j.immuni.2016.06.011
   Lana A, 2017, AGING DIS, V8, P240, DOI 10.14336/AD.2016.0819
   LANDRETH KS, 1992, BLOOD, V80, P1207
   Lange C, 2022, LANCET INFECT DIS, V22, pE2, DOI 10.1016/S1473-3099(21)00403-5
   Langkamp-Henken B, 2004, J AM GERIATR SOC, V52, P3, DOI 10.1111/j.1532-5415.2004.52003.x
   Lanna A, 2017, NAT IMMUNOL, V18, P354, DOI 10.1038/ni.3665
   Lapuente D, 2018, MUCOSAL IMMUNOL, V11, P1265, DOI 10.1038/s41385-018-0017-4
   Lee C., 2016, F1000RES, V5
   Lee H, 2018, GERONTOLOGIST, V58, P159, DOI 10.1093/geront/gnx050
   Lee J, 2002, J NEUROCHEM, V80, P539, DOI 10.1046/j.0022-3042.2001.00747.x
   Levy M, 2016, GENE DEV, V30, P1589, DOI 10.1101/gad.284091.116
   Lewitus GM, 2008, BRAIN BEHAV IMMUN, V22, P1108, DOI 10.1016/j.bbi.2008.05.002
   Lewitus GM, 2009, BIOL PSYCHIAT, V65, P283, DOI 10.1016/j.biopsych.2008.07.014
   Li B, 2007, CELL, V128, P707, DOI 10.1016/j.cell.2007.01.015
   Li YY, 2011, BMC MED, V9, DOI 10.1186/1741-7015-9-98
   Li Y, 2008, NEURON, V59, P399, DOI 10.1016/j.neuron.2008.06.023
   Liu W, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.01115
   Lochner M, 2015, TRENDS IMMUNOL, V36, P81, DOI 10.1016/j.it.2014.12.005
   Lucas CL, 2014, NAT IMMUNOL, V15, P88, DOI 10.1038/ni.2771
   Luo W, 2018, IMMUNITY, V48, P313, DOI 10.1016/j.immuni.2018.01.008
   Macfarlane S, 2013, ALIMENT PHARM THER, V38, P804, DOI 10.1111/apt.12453
   Maciolek JA, 2014, CURR OPIN IMMUNOL, V27, P60, DOI 10.1016/j.coi.2014.01.006
   Maegawa S, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-00607-3
   Maltby VE, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-35603-0
   Mannick JB, 2018, SCI TRANSL MED, V10, DOI 10.1126/scitranslmed.aaq1564
   Mannick JB, 2014, SCI TRANSL MED, V6, DOI 10.1126/scitranslmed.3009892
   Margueron R, 2011, NATURE, V469, P343, DOI 10.1038/nature09784
   Marie-Cardine A, 2008, CLIN IMMUNOL, V127, P14, DOI 10.1016/j.clim.2007.11.013
   Marosi K, 2016, J NEUROCHEM, V139, P769, DOI 10.1111/jnc.13868
   Martin CK, 2007, REJUV RES, V10, P179, DOI 10.1089/rej.2006.0502
   Martinez-Reyes I, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-019-13668-3
   Maruyama M, 2016, INT J FOOD SCI NUTR, V67, P67, DOI 10.3109/09637486.2015.1126564
   Mattison JA, 2012, NATURE, V489, P318, DOI 10.1038/nature11432
   Mattson MP, 2006, NAT REV NEUROSCI, V7, P278, DOI 10.1038/nrn1886
   Maurano MT, 2015, CELL REP, V12, P1184, DOI 10.1016/j.celrep.2015.07.024
   Mazmanian SK, 2005, CELL, V122, P107, DOI 10.1016/j.cell.2005.05.007
   McCubrey JA, 2017, AGING-US, V9, P1477, DOI 10.18632/aging.101250
   Mejias-Pena Y, 2017, AGING-US, V9, P408, DOI 10.18632/aging.101167
   Messaoudi I, 2006, P NATL ACAD SCI USA, V103, P19448, DOI 10.1073/pnas.0606661103
   Miller JP, 2003, J IMMUNOL, V171, P2326, DOI 10.4049/jimmunol.171.5.2326
   Milutinovic B, 2016, SEMIN IMMUNOL, V28, P328, DOI 10.1016/j.smim.2016.05.004
   Minor RK, 2011, SCI REP-UK, V1, DOI 10.1038/srep00070
   Miranda M, 2019, FRONT CELL NEUROSCI, V13, DOI 10.3389/fncel.2019.00363
   Mitroulis I, 2018, CELL, V172, P147, DOI 10.1016/j.cell.2017.11.034
   Monje ML, 2003, SCIENCE, V302, P1760, DOI 10.1126/science.1088417
   Montecino-Rodriguez E, 2006, NAT IMMUNOL, V7, P293, DOI 10.1038/ni1301
   Moore LD, 2013, NEUROPSYCHOPHARMACOL, V38, P23, DOI 10.1038/npp.2012.112
   Moorlag SJCFM, 2020, CELL REP, V33, DOI 10.1016/j.celrep.2020.108387
   Morales AJ, 2017, ELIFE, V6, DOI 10.7554/eLife.24655
   Moreira OC, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/2012798
   Moskowitz DM, 2017, SCI IMMUNOL, V2, DOI 10.1126/sciimmunol.aag0192
   Mourits VP, 2021, CELL IMMUNOL, V366, DOI 10.1016/j.cellimm.2021.104393
   Muggen AF, 2019, IMMUN AGEING, V16, DOI 10.1186/s12979-019-0163-x
   Muller-Sieburg CE, 2012, BLOOD, V119, P3900, DOI 10.1182/blood-2011-12-376749
   Musso G, 2010, DIABETES CARE, V33, P2277, DOI 10.2337/dc10-0556
   Myers DR, 2019, IMMUNOL REV, V291, P134, DOI 10.1111/imr.12796
   Naik S, 2017, NATURE, V550, P475, DOI 10.1038/nature24271
   Naradikian MS, 2016, IMMUNOL REV, V269, P118, DOI 10.1111/imr.12380
   Negi S, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.02441
   Netea MG, 2020, NAT REV IMMUNOL, V20, P375, DOI 10.1038/s41577-020-0285-6
   Netea MG, 2019, CELL HOST MICROBE, V25, P13, DOI 10.1016/j.chom.2018.12.006
   Netea MG, 2016, SCIENCE, V352, DOI 10.1126/science.aaf1098
   Netea MG, 2011, CELL HOST MICROBE, V9, P355, DOI 10.1016/j.chom.2011.04.006
   Nielsen S, 2021, ECLINICALMEDICINE, V36, DOI 10.1016/j.eclinm.2021.100886
   NIEMAN DC, 1993, MED SCI SPORT EXER, V25, P823, DOI 10.1249/00005768-199307000-00011
   Nipper AJ, 2018, CLIN IMMUNOL, V193, P80, DOI 10.1016/j.clim.2018.02.003
   Norden DM, 2015, NEUROPHARMACOLOGY, V96, P29, DOI 10.1016/j.neuropharm.2014.10.028
   Oakes CC, 2003, P NATL ACAD SCI USA, V100, P1775, DOI 10.1073/pnas.0437971100
   Ohrui Takashi, 2005, Nihon Ronen Igakkai Zasshi, V42, P34
   Olah M, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-018-02926-5
   Organization WH, 2020, STAT COVID 19 VACC W
   Ospelt C, 2011, AUTOIMMUN REV, V10, P519, DOI 10.1016/j.autrev.2011.04.001
   Ouyang J, 2020, FRONT IMMUNOL, V11, DOI 10.3389/fimmu.2020.00645
   Owens BMJ, 2015, FRONT IMMUNOL, V6, DOI 10.3389/fimmu.2015.00319
   Pacis A, 2015, GENOME RES, V25, P1801, DOI 10.1101/gr.192005.115
   Palma C, 2021, CELL METAB, V33, P300, DOI 10.1016/j.cmet.2020.12.016
   Palmer DB, 2013, FRONT IMMUNOL, V4, DOI 10.3389/fimmu.2013.00316
   Palmer MJ, 2008, CELL MOL IMMUNOL, V5, P79, DOI 10.1038/cmi.2008.10
   Patel AA, 2017, J EXP MED, V214, P1913, DOI 10.1084/jem.20170355
   Patel NV, 2005, NEUROBIOL AGING, V26, P995, DOI 10.1016/j.neurobiolaging.2004.09.014
   Pawelec G, 2018, EXP GERONTOL, V105, P4, DOI 10.1016/j.exger.2017.10.024
   Pearson KJ, 2008, CELL METAB, V8, P157, DOI 10.1016/j.cmet.2008.06.011
   Peng M, 2016, SCIENCE, V354, P481, DOI 10.1126/science.aaf6284
   Pereira B, 2020, FRONT IMMUNOL, V11, DOI 10.3389/fimmu.2020.583019
   Perrotta F, 2020, AGING CLIN EXP RES, V32, P1599, DOI 10.1007/s40520-020-01631-y
   Peterson DA, 2007, CELL HOST MICROBE, V2, P328, DOI 10.1016/j.chom.2007.09.013
   Pifferi F, 2019, PROG NEURO-PSYCHOPH, V95, DOI 10.1016/j.pnpbp.2019.109702
   Pillai S, 2009, NAT REV IMMUNOL, V9, P767, DOI 10.1038/nri2656
   Placek K, 2019, CURR OPIN INFECT DIS, V32, P196, DOI 10.1097/QCO.0000000000000540
   Poon HF, 2006, NEUROBIOL AGING, V27, P1020, DOI 10.1016/j.neurobiolaging.2005.05.014
   Popkes M, 2020, PHILOS T R SOC B, V375, DOI 10.1098/rstb.2019.0596
   Pougovkina O, 2014, HUM MOL GENET, V23, P3513, DOI 10.1093/hmg/ddu059
   Poulsen MM, 2013, DIABETES, V62, P1186, DOI 10.2337/db12-0975
   Prehn K, 2017, CEREB CORTEX, V27, P1765, DOI 10.1093/cercor/bhw008
   Prinz M, 2019, CELL, V179, P292, DOI 10.1016/j.cell.2019.08.053
   Pritz T, 2015, EUR J IMMUNOL, V45, P738, DOI 10.1002/eji.201444878
   Puntener U, 2012, J NEUROINFLAMM, V9, DOI 10.1186/1742-2094-9-146
   Puleston DJ, 2014, ELIFE, V3, DOI 10.7554/eLife.03706
   Qi Q, 2014, P NATL ACAD SCI USA, V111, P13139, DOI 10.1073/pnas.1409155111
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Qin WP, 2006, J BIOL CHEM, V281, P21745, DOI 10.1074/jbc.M602909200
   Qu H, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0211233
   Quinn KM, 2018, CELL REP, V23, P3512, DOI 10.1016/j.celrep.2018.05.057
   Quintin J, 2012, CELL HOST MICROBE, V12, P223, DOI 10.1016/j.chom.2012.06.006
   Ragonnaud E, 2021, IMMUN AGEING, V18, DOI 10.1186/s12979-020-00213-w
   Rajagopalan S, 2010, SCI SIGNAL, V3, DOI 10.1126/scisignal.2000467
   Rampelli S, 2013, J NUTR HEALTH AGING, V17, P166, DOI 10.1007/s12603-012-0372-x
   Rathmell JC, 2001, J IMMUNOL, V167, P6869, DOI 10.4049/jimmunol.167.12.6869
   Rathmell JC, 2000, MOL CELL, V6, P683, DOI 10.1016/S1097-2765(00)00066-6
   Ratliff M, 2013, AGING CELL, V12, P303, DOI 10.1111/acel.12055
   Ravussin E, 2015, J GERONTOL A-BIOL, V70, P1097, DOI 10.1093/gerona/glv057
   Rhoades N, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.00463
   Riley RL, 2005, IMMUNOL REV, V205, P30, DOI 10.1111/j.0105-2896.2005.00268.x
   Ritzel RM, 2016, J IMMUNOL, V196, P3318, DOI 10.4049/jimmunol.1502021
   Rivas MN, 2021, J CLIN INVEST, V131, DOI 10.1172/JCI145157
   Rodriguez-Zhurbenko N, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.00483
   Rojas OL, 2019, CELL, V176, P610, DOI 10.1016/j.cell.2018.11.035
   Ron-Harel N, 2008, REJUV RES, V11, P903, DOI 10.1089/rej.2008.0755
   Ron-Harel N, 2018, P NATL ACAD SCI USA, V115, P13347, DOI 10.1073/pnas.1804149115
   Ron-Harel N, 2009, TRENDS NEUROSCI, V32, P367, DOI 10.1016/j.tins.2009.03.003
   Rosenblum MD, 2016, NAT REV IMMUNOL, V16, P90, DOI 10.1038/nri.2015.1
   Rossi DJ, 2005, P NATL ACAD SCI USA, V102, P9194, DOI 10.1073/pnas.0503280102
   Round JL, 2009, NAT REV IMMUNOL, V9, P313, DOI 10.1038/nri2515
   Roychoudhuri R, 2013, NATURE, V498, P506, DOI 10.1038/nature12199
   Rubio-Ruiz Maria Esther, 2015, Int J Evol Biol, V2015, P179791, DOI 10.1155/2015/179791
   Rubtsov AV, 2015, J IMMUNOL, V195, P71, DOI 10.4049/jimmunol.1500055
   Rubtsov AV, 2011, BLOOD, V118, P1305, DOI 10.1182/blood-2011-01-331462
   Rubtsova K, 2015, J IMMUNOL, V195, P1933, DOI 10.4049/jimmunol.1501209
   Ruderman NB, 2010, AM J PHYSIOL-ENDOC M, V298, pE751, DOI 10.1152/ajpendo.00745.2009
   Rube CE, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0017487
   Saeed S, 2014, SCIENCE, V345, P1578, DOI 10.1126/science.1251086
   Sainz N, 2015, METABOLISM, V64, P35, DOI 10.1016/j.metabol.2014.10.015
   Sakaguchi S, 2008, CELL, V133, P775, DOI 10.1016/j.cell.2008.05.009
   Salosensaari A, 2021, NAT COMMUN, V12, DOI 10.1038/s41467-021-22962-y
   Sarkar SR, 2020, J NEUROIMMUNOL, V348, DOI 10.1016/j.jneuroim.2020.577390
   Sathaliyawala T, 2013, IMMUNITY, V38, P187, DOI 10.1016/j.immuni.2012.09.020
   Saurwein-Teissl M, 2002, J IMMUNOL, V168, P5893, DOI 10.4049/jimmunol.168.11.5893
   Schulthess J, 2019, IMMUNITY, V50, P432, DOI 10.1016/j.immuni.2018.12.018
   Schulz AR, 2015, J IMMUNOL, V195, P4699, DOI 10.4049/jimmunol.1500598
   Shanley DP, 2009, TRENDS IMMUNOL, V30, P374, DOI 10.1016/j.it.2009.05.001
   Shen X, 2018, GUT PATHOG, V10, DOI 10.1186/s13099-018-0231-3
   Shin HN, 2012, NATURE, V491, P463, DOI 10.1038/nature11522
   Shitara S, 2013, J IMMUNOL, V190, P6173, DOI 10.4049/jimmunol.1202573
   Simanek AM, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0016103
   Simpson RJ, 2012, AGEING RES REV, V11, P404, DOI 10.1016/j.arr.2012.03.003
   Sleiman SF, 2016, ELIFE, V5, DOI 10.7554/eLife.15092
   Spinelli R, 2020, J ENDOCRINOL INVEST, V43, P1373, DOI 10.1007/s40618-020-01255-z
   Strahl BD, 2000, NATURE, V403, P41, DOI 10.1038/47412
   Strong R, 2013, J GERONTOL A-BIOL, V68, P6, DOI 10.1093/gerona/gls070
   Suarez-Alvarez B, 2017, AGING CELL, V16, P293, DOI 10.1111/acel.12552
   Sun DQ, 2014, CELL STEM CELL, V14, P673, DOI 10.1016/j.stem.2014.03.002
   Swain SL, 2017, CELL IMMUNOL, V321, P52, DOI 10.1016/j.cellimm.2017.05.009
   Szuhany KL, 2015, J PSYCHIATR RES, V60, P56, DOI 10.1016/j.jpsychires.2014.10.003
   Tabibian-Keissar H, 2016, EUR J IMMUNOL, V46, P480, DOI 10.1002/eji.201545586
   Taiwo O, 2013, EPIGENETICS-US, V8, P1114, DOI 10.4161/epi.26017
   Tanoue T, 2016, NAT REV IMMUNOL, V16, P295, DOI 10.1038/nri.2016.36
   Thome JJC, 2016, SCI IMMUNOL, V1, DOI 10.1126/sciimmunol.aah6506
   Thome JJC, 2016, NAT MED, V22, P72, DOI 10.1038/nm.4008
   Thome JJC, 2014, CELL, V159, P814, DOI 10.1016/j.cell.2014.10.026
   Tilly G, 2017, FRONT IMMUNOL, V8, DOI 10.3389/fimmu.2017.00778
   Timmers S, 2011, CELL METAB, V14, P612, DOI 10.1016/j.cmet.2011.10.002
   Tolppanen AM, 2015, ALZHEIMERS DEMENT, V11, P434, DOI 10.1016/j.jalz.2014.01.008
   Torigoe M, 2017, J IMMUNOL, V199, P425, DOI 10.4049/jimmunol.1601908
   Tsay GJ, 2018, FRONT IMMUNOL, V9, DOI 10.3389/fimmu.2018.01064
   Tserel L, 2015, SCI REP-UK, V5, DOI 10.1038/srep13107
   Ucar D, 2017, J EXP MED, V214, P3123, DOI 10.1084/jem.20170416
   Ursell LK, 2012, NUTR REV, V70, pS38, DOI 10.1111/j.1753-4887.2012.00493.x
   Valenzuela PL, 2020, AGEING RES REV, V62, DOI 10.1016/j.arr.2020.101108
   van der Heijden CDCC, 2018, ANTIOXID REDOX SIGN, V29, P1023, DOI 10.1089/ars.2017.7310
   van der Heijden CDCC, 2020, CARDIOVASC RES, V116, P317, DOI 10.1093/cvr/cvz137
   van der Windt GJW, 2013, P NATL ACAD SCI USA, V110, P14336, DOI 10.1073/pnas.1221740110
   van der Windt GJW, 2012, IMMUNITY, V36, P68, DOI 10.1016/j.immuni.2011.12.007
   Verma D, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-12110-2
   Vieira SM, 2018, SCIENCE, V359, P1156, DOI 10.1126/science.aar7201
   von Schwartzenberg RJ, 2021, NATURE, V595, P272, DOI 10.1038/s41586-021-03663-4
   Wang HS, 2012, P NATL ACAD SCI USA, V109, P20077, DOI 10.1073/pnas.1212428109
   Wang J, 2005, FASEB J, V19, P659, DOI 10.1096/fj.04-3182fje
   Wang Q, 2017, MED SCI MONITOR, V23, DOI 10.12659/MSM.900754
   Wang TN, 2017, GENOME BIOL, V18, DOI 10.1186/s13059-017-1186-2
   Wardhana, 2011, Acta Med Indones, V43, P185
   Waters LR, 2018, ISCIENCE, V5, P99, DOI 10.1016/j.isci.2018.07.005
   Wei L, 2012, CELL REP, V2, P1151, DOI 10.1016/j.celrep.2012.10.013
   Weinberg SE, 2015, IMMUNITY, V42, P406, DOI 10.1016/j.immuni.2015.02.002
   Wendeln AC, 2018, NATURE, V556, P332, DOI 10.1038/s41586-018-0023-4
   Wiertsema SP, 2021, NUTRIENTS, V13, DOI 10.3390/nu13030886
   Wilkins LJ, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-49452-y
   Willinger T, 2005, J IMMUNOL, V175, P5895, DOI 10.4049/jimmunol.175.9.5895
   Wilmanski T, 2021, NAT METAB, V3, P274, DOI 10.1038/s42255-021-00348-0
   Wirth M, 2014, NEUROBIOL AGING, V35, P1873, DOI 10.1016/j.neurobiolaging.2014.02.015
   Witte AV, 2009, P NATL ACAD SCI USA, V106, P1255, DOI 10.1073/pnas.0808587106
   Wong JB, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-12824-z
   Woods JA, 2009, J AM GERIATR SOC, V57, P2183, DOI 10.1111/j.1532-5415.2009.02563.x
   Xu CM, 2019, BMC MICROBIOL, V19, DOI 10.1186/s12866-019-1616-2
   Yamamoto Y, 2019, ACTA ODONTOL SCAND, V77, P517, DOI 10.1080/00016357.2019.1609697
   Yanes RE, 2019, CLIN IMMUNOL, V207, P58, DOI 10.1016/j.clim.2019.07.003
   Yang HJ, 2019, FRONT NEUROL, V10, DOI 10.3389/fneur.2019.00585
   Yi SJ, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21218241
   Yoles E, 2001, J NEUROSCI, V21, P3740, DOI 10.1523/JNEUROSCI.21-11-03740.2001
   Yu YJ, 2011, TRENDS MICROBIOL, V19, P360, DOI 10.1016/j.tim.2011.04.002
   Zeng T, 2019, BIOGERONTOLOGY, V20, P837, DOI 10.1007/s10522-019-09830-5
   Zens KD, 2016, JCI INSIGHT, V1, DOI 10.1172/jci.insight.85832
   Zhang CH, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms3163
   Zhang ZD, 2016, IMMUNITY, V44, P330, DOI 10.1016/j.immuni.2016.01.004
   Zhao M, 2016, SCI REP-UK, V6, DOI 10.1038/srep38411
   Zhao Q, 2018, IMMUNOLOGY, V154, P28, DOI 10.1111/imm.12896
   Zheng DP, 2020, CELL RES, V30, P492, DOI 10.1038/s41422-020-0332-7
   Ziv Y, 2006, NAT NEUROSCI, V9, P268, DOI 10.1038/nn1629
   Zuhair M, 2019, REV MED VIROL, V29, DOI 10.1002/rmv.2034
NR 389
TC 7
Z9 7
U1 3
U2 18
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 1080-0549
EI 1559-0267
J9 CLIN REV ALLERG IMMU
JI Clin. Rev. Allergy Immunol.
PD DEC
PY 2022
VL 63
IS 3
SI SI
BP 499
EP 529
DI 10.1007/s12016-021-08905-x
EA DEC 2021
PG 31
WC Allergy; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Allergy; Immunology
GA 6H2XS
UT WOS:000730500200001
PM 34910283
OA hybrid, Green Published
DA 2023-06-08
ER

PT J
AU Yuan, YY
   Liu, SH
   Ding, XF
   Li, Y
   Zhang, XJ
   Song, H
   Qi, XY
   Zhang, ZH
   Guo, KY
   Sun, TW
AF Yuan, Yangyang
   Liu, Shaohua
   Ding, Xianfei
   Li, Ying
   Zhang, Xiaojuan
   Song, Heng
   Qi, Xueyan
   Zhang, Zihao
   Guo, Kaiyuan
   Sun, Tongwen
TI Early intestinal microbiota changes in aged and adult mice with sepsis
SO FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
LA English
DT Article
DE sepsis; intestinal microbiota; aged mice; adult mice; 16S
ID CHAIN FATTY-ACIDS; EPITHELIAL BARRIER FUNCTION; GUT MICROBIOTA;
   AKKERMANSIA-MUCINIPHILA; CRITICAL ILLNESS; PHYSIOLOGY; INJURY;
   IMMUNOSUPPRESSION; INFLAMMATION; METFORMIN
AB BackgroundThe mortality rate associated with sepsis in elderly individuals is higher than that in younger individuals. The intestinal microbiota has been demonstrated to play an important role in the occurrence and development of sepsis. The purpose of this study was to investigate the differences in the intestinal microbiota between aged and adult mice with sepsis. MethodsThirty male C57BL mice were randomly divided into two groups: 15 in the adult group (AD group) and 15 in the age group (Age group). All the mice underwent caecal ligation and puncture to induce sepsis. Mice faeces were collected, and analysed using 16S rRNA sequencing. The liver and colon tissues were collected. ResultsThere were significant differences in intestinal microbiota composition between the two groups. Compared with adult sepsis mice, the diversity of intestinal microbiota in the aged group was significantly reduced and the structure of dominant intestinal microbiota was changed. In the Age group, the microbiota associated with inflammatory factors increased, and the microbiota associated with the production of SCFAs (Ruminiclostridium, Prevotellaceae_UCG-001, Rikenella, Parabacteroides, Oscillibacter, Odoribacter, Muribaculum, Lachnoclostridium, Intestinimonas, Faecalibaculum, Anaerotruncus, Alloprevotella and Absiella) decreased. The metabolic pathways related to the microbiota also changed. Moreover, the proportion of inflammatory factors in Age group was higher than that in AD group. ConclusionOur results showed that there were significant differences in the abundance and structure of microbiota between aged and adult sepsis mice, Aged sepsis mice have more severe intestinal microbiota destruction and liver tissue inflammation than adult sepsis mice.
C1 [Yuan, Yangyang; Liu, Shaohua; Ding, Xianfei; Zhang, Xiaojuan; Song, Heng; Qi, Xueyan; Sun, Tongwen] Zhengzhou Univ, Henan Engn Res Ctr Crit Care Med, Gen Intens Care Unit, Henan Key Lab Crit Care Med,Affiliated Hosp 1, Zhengzhou, Peoples R China.
   [Yuan, Yangyang; Liu, Shaohua; Ding, Xianfei; Zhang, Xiaojuan; Song, Heng; Qi, Xueyan; Sun, Tongwen] Zhengzhou Key Lab Sepsis, Zhengzhou, Peoples R China.
   [Li, Ying; Song, Heng; Guo, Kaiyuan] Zhengzhou Univ, Acad Med Sci, Zhengzhou, Peoples R China.
   [Zhang, Zihao] Xinxiang Med Univ, Sanquan Coll, Xinxiang, Peoples R China.
C3 Zhengzhou University; Zhengzhou University; Xinxiang Medical University
RP Sun, TW (通讯作者)，Zhengzhou Univ, Henan Engn Res Ctr Crit Care Med, Gen Intens Care Unit, Henan Key Lab Crit Care Med,Affiliated Hosp 1, Zhengzhou, Peoples R China.; Sun, TW (通讯作者)，Zhengzhou Key Lab Sepsis, Zhengzhou, Peoples R China.
EM suntongwen@163.com
RI Sun, Tongwen/AAQ-7741-2020
FU United Fund of National Natural Science Foundation of China [U2004110];
   National Natural Science Foundation of China [82172129, 82202370]; 2021
   Youth Talent Promotion Project in Henan Province [2021HYTP053]; 2021
   joint construction project of Henan Medical Science and Technology
   Breakthrough Plan [LHGJ20210299]; Central government guides local
   science and technology development funds [Z20221343037]; Medical Science
   and Technology Tackling Plan Provincial and Ministerial Major Projects
   of Henan Province [SBGJ202101015]
FX This study was supported by the United Fund of National Natural Science
   Foundation of China (grant number U2004110), the National Natural
   Science Foundation of China (grant number 82172129, 82202370), the 2021
   Youth Talent Promotion Project in Henan Province (grant number
   2021HYTP053), the 2021 joint construction project of Henan Medical
   Science and Technology Breakthrough Plan (grant number LHGJ20210299),
   the central government guides local science and technology development
   funds ( grant number Z20221343037), Medical Science and Technology
   Tackling Plan Provincial and Ministerial Major Projects of Henan
   Province (Grant No. SBGJ202101015).
CR Adak A, 2019, CELL MOL LIFE SCI, V76, P473, DOI 10.1007/s00018-018-2943-4
   Adelman MW, 2020, CRIT CARE, V24, DOI 10.1186/s13054-020-02989-1
   Agudelo-Ochoa GM, 2020, GUT MICROBES, V12, DOI 10.1080/19490976.2019.1707610
   Alverdy JC, 2017, CRIT CARE MED, V45, P337, DOI [10.1097/CCM.0000000000002172, 10.1097/ccm.0000000000002172]
   Belkaid Y, 2014, CELL, V157, P121, DOI 10.1016/j.cell.2014.03.011
   Biagi E, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0010667
   Blacker TS, 2016, FREE RADICAL BIO MED, V100, P53, DOI 10.1016/j.freeradbiomed.2016.08.010
   Brakenridge SC, 2019, ANN SURG, V270, P502, DOI 10.1097/SLA.0000000000003458
   Bui TPN, 2016, ENV MICROBIOL REP, V8, P1024, DOI 10.1111/1758-2229.12483
   Collado MC, 2007, APPL ENVIRON MICROB, V73, P7767, DOI 10.1128/AEM.01477-07
   Crouch LI, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-17847-5
   Cui YQ, 2020, FRONT PHARMACOL, V11, DOI 10.3389/fphar.2020.00902
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   De Vuyst L, 2014, J APPL MICROBIOL, V116, P477, DOI 10.1111/jam.12415
   Deng F, 2023, J MED VIROL, V95, DOI 10.1002/jmv.28267
   Deng F, 2022, INT J BIOL SCI, V18, P858, DOI 10.7150/ijbs.67724
   Deng F, 2021, GUT MICROBES, V13, DOI 10.1080/19490976.2021.1902719
   Fay KT, 2017, BBA-MOL BASIS DIS, V1863, P2574, DOI 10.1016/j.bbadis.2017.03.005
   Frank DN, 2007, P NATL ACAD SCI USA, V104, P13780, DOI 10.1073/pnas.0706625104
   Fransen F, 2017, FRONT IMMUNOL, V8, DOI 10.3389/fimmu.2017.01385
   Fulop T, 2018, FRONT IMMUNOL, V8, DOI 10.3389/fimmu.2017.01960
   Geerlings SY, 2018, MICROORGANISMS, V6, DOI 10.3390/microorganisms6030075
   Ginde AA, 2014, SHOCK, V42, P99, DOI 10.1097/SHK.0000000000000182
   Haak BW, 2017, LANCET GASTROENTEROL, V2, P135, DOI 10.1016/S2468-1253(16)30119-4
   Hotchkiss RS, 2013, LANCET INFECT DIS, V13, P260, DOI 10.1016/S1473-3099(13)70001-X
   Hu JJ, 2022, MICROBIOME, V10, DOI 10.1186/s40168-022-01227-w
   Johansson MEV, 2013, NAT REV GASTRO HEPAT, V10, P352, DOI 10.1038/nrgastro.2013.35
   Kale SS, 2011, AGING DIS, V2, P501
   Kelly CJ, 2015, CELL HOST MICROBE, V17, P662, DOI 10.1016/j.chom.2015.03.005
   Koh A, 2016, CELL, V165, P1332, DOI 10.1016/j.cell.2016.05.041
   Koh GY, 2020, CARCINOGENESIS, V41, P909, DOI 10.1093/carcin/bgaa018
   Lee JH, 2010, MICROBIOL MOL BIOL R, V74, P378, DOI 10.1128/MMBR.00004-10
   Leentjens J, 2013, AM J RESP CRIT CARE, V187, P1287, DOI 10.1164/rccm.201301-0036CP
   Leonel AJ, 2012, CURR OPIN CLIN NUTR, V15, P474, DOI 10.1097/MCO.0b013e32835665fa
   Liang HY, 2022, EMERG MICROBES INFEC, V11, P815, DOI 10.1080/22221751.2022.2045876
   Lin CH, 2019, J NEUROINFLAMM, V16, DOI 10.1186/s12974-019-1528-y
   Lin L, 2017, BMC IMMUNOL, V18, DOI 10.1186/s12865-016-0187-3
   Liu J, 2018, PHARMACOL RES, V134, P40, DOI 10.1016/j.phrs.2018.05.012
   Ma JW, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-15636-8
   Mariat D, 2009, BMC MICROBIOL, V9, DOI 10.1186/1471-2180-9-123
   McGuckin MA, 2011, NAT REV MICROBIOL, V9, P265, DOI 10.1038/nrmicro2538
   Milbrandt EB, 2010, AM J RESP CRIT CARE, V182, P995, DOI 10.1164/rccm.200904-0630CP
   Miller WD, 2021, J INFECT DIS, V223, pS264, DOI 10.1093/infdis/jiaa682
   Morrison DJ, 2016, GUT MICROBES, V7, P189, DOI 10.1080/19490976.2015.1134082
   Nava GM, 2011, ISME J, V5, P627, DOI 10.1038/ismej.2010.161
   Nogal A, 2021, FRONT MICROBIOL, V12, DOI 10.3389/fmicb.2021.711359
   Patra KC, 2014, TRENDS BIOCHEM SCI, V39, P347, DOI 10.1016/j.tibs.2014.06.005
   Rittirsch D, 2008, NAT REV IMMUNOL, V8, P776, DOI 10.1038/nri2402
   Sandhu BK, 2018, TRENDS MICROBIOL, V26, P1049, DOI 10.1016/j.tim.2018.09.004
   Schulthess J, 2019, IMMUNITY, V50, P432, DOI 10.1016/j.immuni.2018.12.018
   Sepandi M, 2019, PHARMACOL RES, V148, DOI 10.1016/j.phrs.2019.104407
   Shankar-Hari M, 2016, JAMA-J AM MED ASSOC, V315, P775, DOI 10.1001/jama.2016.0289
   Shi HJ, 2017, FOOD FUNCT, V8, P3383, DOI 10.1039/c7fo00932a
   Shimizu K, 2006, J TRAUMA, V60, P126, DOI 10.1097/01.ta.0000197374.99755.fe
   Shreiner AB, 2015, CURR OPIN GASTROEN, V31, P69, DOI 10.1097/MOG.0000000000000139
   Smith PM, 2013, SCIENCE, V341, P569, DOI 10.1126/science.1241165
   Sun T., 2022, INTENSIVE CARE RES, V2, P1, DOI [10.1007/s44231-022-00001-8, DOI 10.1007/S44231-022-00001-8]
   Tanca A, 2017, MICROBIOME, V5, DOI 10.1186/s40168-017-0293-3
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Van den Abbeele P, 2020, J AGR FOOD CHEM, V68, P13102, DOI 10.1021/acs.jafc.9b05085
   Vincent JL, 2014, LANCET RESP MED, V2, P380, DOI 10.1016/S2213-2600(14)70061-X
   Wang CY, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.01873
   Wang HB, 2012, DIGEST DIS SCI, V57, P3126, DOI 10.1007/s10620-012-2259-4
   Wang YY, 2018, ENZYME MICROB TECH, V117, P1, DOI 10.1016/j.enzmictec.2018.05.016
   Woodmansey EJ, 2007, J APPL MICROBIOL, V102, P1178, DOI 10.1111/j.1365-2672.2007.03400.x
   Wu GY, 1998, BIOCHEM J, V336, P1, DOI 10.1042/bj3360001
   Xiao SW, 2020, APPL MICROBIOL BIOT, V104, P303, DOI 10.1007/s00253-019-10174-w
   Xiao WS, 2018, ANTIOXID REDOX SIGN, V28, P251, DOI 10.1089/ars.2017.7216
   Xu BY, 2020, BIOMED PHARMACOTHER, V123, DOI 10.1016/j.biopha.2019.109720
   Yamada T, 2015, JPEN-PARENTER ENTER, V39, P569, DOI 10.1177/0148607114529596
   Yao Y, 2020, PHYTOMEDICINE, V77, DOI 10.1016/j.phymed.2020.153268
   Zhai QX, 2019, CRIT REV FOOD SCI, V59, P3227, DOI 10.1080/10408398.2018.1517725
   Zhang T, 2019, MICROB BIOTECHNOL, V12, P1109, DOI 10.1111/1751-7915.13410
   Zhang X, 2015, SCI REP-UK, V5, DOI 10.1038/srep14405
   Zhang Yanpei, 2021, Zhong Nan Da Xue Xue Bao Yi Xue Ban, V46, P889, DOI 10.11817/j.issn.1672-7347.2021.200351
   Zheng L, 2017, J IMMUNOL, V199, P2976, DOI 10.4049/jimmunol.1700105
   Zhou D, 2017, WORLD J GASTROENTERO, V23, P60, DOI 10.3748/wjg.v23.i1.60
NR 77
TC 2
Z9 2
U1 4
U2 4
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2235-2988
J9 FRONT CELL INFECT MI
JI Front. Cell. Infect. Microbiol.
PD DEC 27
PY 2022
VL 12
AR 1061444
DI 10.3389/fcimb.2022.1061444
PG 13
WC Immunology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Microbiology
GA 7T3RJ
UT WOS:000911361800001
PM 36636721
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Ding, QZ
   Zhang, BW
   Zheng, W
   Chen, XJ
   Zhang, J
   Yan, RY
   Zhang, T
   Yu, LY
   Dong, YS
   Ma, BP
AF Ding, Qianzhi
   Zhang, Bowei
   Zheng, Wei
   Chen, Xiaojuan
   Zhang, Jie
   Yan, Renyi
   Zhang, Tao
   Yu, Liyan
   Dong, Yuesheng
   Ma, Baiping
TI Liupao tea extract alleviates diabetes mellitus and modulates gut
   microbiota in rats induced by streptozotocin and high-fat, high-sugar
   diet
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Dark tea; Liupao tea; Gut microbiota; Diabetes mellitus; Prevotella;
   Short-chain fatty acid
ID AKKERMANSIA-MUCINIPHILA; OBESITY; POLYSACCHARIDES; ANTIOXIDANT;
   POLYPHENOLS; METABOLITES; ALTERS; IMPACT; GREEN; ACIDS
AB Liupao tea, a popular dark tea, exhibited anti-diabetic activity in Chinese tea culture. However, the bioavailability of the main active components is low. Therefore, the relationship between the anti-diabetic activity and the modulation of gut microbiota was investigated in this study for the first time. Liupao tea extract (LTE) could significantly alleviate hyperglycemia, insulin-resistance, and plasma lipid profiles. The hypoglycemic effect of high-dose LTE was comparable to that of metformin. Importantly, LTE exhibited beneficial effect on modulating the diabetic-induced disorder of gut microbiota, such as increasing Bacteroidetes/Firmicutes ratio and up-regulating putative short-chain fatty acid (SCFA)-producing bacteria, including Prevotella and Bacteroides. Moreover, 29 key phylotypes were significantly correlated with at least one diabetic index. In conclusion, LTE could be developed into an anti-diabetic functional beverage and its beneficial effects is likely to be associated with the prebiotic effects for increasing the level of SCFAs and the relative abundance of SCFA-producing bacteria.
C1 [Ding, Qianzhi; Zheng, Wei; Chen, Xiaojuan; Zhang, Jie; Yan, Renyi; Ma, Baiping] Beijing Inst Radiat Med, 27 Taiping Rd, Beijing 100850, Peoples R China.
   [Zhang, Bowei; Dong, Yuesheng] Dalian Univ Technol, Sch Life Sci & Biotechnol, 2 Linggong Rd, Dalian 116024, Peoples R China.
   [Zhang, Tao; Yu, Liyan] Chinese Acad Med Sci, Inst Med Biotechnol, 1 Tian Tan Xi Li, Beijing 100050, Peoples R China.
   [Zhang, Tao; Yu, Liyan] Peking Union Med Coll, 1 Tian Tan Xi Li, Beijing 100050, Peoples R China.
C3 Academy of Military Medical Sciences - China; Dalian University of
   Technology; Chinese Academy of Medical Sciences - Peking Union Medical
   College; Institute of Medicinal Biotechnology - CAMS; Chinese Academy of
   Medical Sciences - Peking Union Medical College; Peking Union Medical
   College
RP Ma, BP (通讯作者)，Beijing Inst Radiat Med, 27 Taiping Rd, Beijing 100850, Peoples R China.; Dong, YS (通讯作者)，Dalian Univ Technol, Sch Life Sci & Biotechnol, 2 Linggong Rd, Dalian 116024, Peoples R China.
EM yshdong@dlut.edu.cn; mabaiping@sina.com
RI Dong, yuesheng/ABA-7029-2020; yu, liyan/GYD-2950-2022
OI yu, liyan/0000-0002-8861-9806
FU National Natural Science Foundation of China [81773867]
FX The authors thank Annoroad Gene Tech. (Beijing) Co., Ltd for their
   excellent technical assistance. This study was supported by the National
   Natural Science Foundation of China [grant number 81773867].
CR Anhe FF, 2015, GUT, V64, P872, DOI 10.1136/gutjnl-2014-307142
   Blandino G, 2016, DIABETES METAB, V42, P303, DOI 10.1016/j.diabet.2016.04.004
   Canfora EE, 2019, NAT REV ENDOCRINOL, V15, P261, DOI 10.1038/s41574-019-0156-z
   Chang CJ, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms8489
   Cheng Q, 2015, J FOOD SCI TECH MYS, V52, P928, DOI 10.1007/s13197-013-1059-y
   Dai WD, 2017, FOOD RES INT, V96, P40, DOI 10.1016/j.foodres.2017.03.028
   Danda RS, 2005, KIDNEY INT, V68, P2562, DOI 10.1111/j.1523-1755.2005.00727.x
   De Filippo C, 2010, P NATL ACAD SCI USA, V107, P14691, DOI 10.1073/pnas.1005963107
   Ding QZ, 2019, RSC ADV, V9, P2967, DOI 10.1039/c8ra09259a
   Dong H, 2017, BMC MICROBIOL, V17, DOI 10.1186/s12866-017-1058-7
   Edgar RC, 2010, BIOINFORMATICS, V26, P2460, DOI 10.1093/bioinformatics/btq461
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   He CX, 2015, NUTR RES, V35, P361, DOI 10.1016/j.nutres.2015.03.002
   Henning SM, 2018, EUR J NUTR, V57, P2759, DOI 10.1007/s00394-017-1542-8
   Hollman PCH, 2000, J SCI FOOD AGR, V80, P1081, DOI 10.1002/(SICI)1097-0010(20000515)80:7&lt;1081::AID-JSFA566&gt;3.0.CO;2-G
   Hsiao EY, 2013, CELL, V155, P1451, DOI 10.1016/j.cell.2013.11.024
   Jia ZX, 2014, RAPID COMMUN MASS SP, V28, P2237, DOI 10.1002/rcm.7014
   Kim CH, 2018, CELL MOL IMMUNOL, V15, P88, DOI 10.1038/cmi.2017.57
   Le Kim-Anne, 2012, Front Physiol, V3, P496, DOI 10.3389/fphys.2012.00496
   Ley RE, 2005, P NATL ACAD SCI USA, V102, P11070, DOI 10.1073/pnas.0504978102
   Lin A, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0053838
   Lippert K, 2017, BENEF MICROBES, V8, P545, DOI 10.3920/BM2016.0184
   Liu GM, 2018, MOL NUTR FOOD RES, V62, DOI 10.1002/mnfr.201700954
   Liu SY, 2016, BMC COMPLEM ALTERN M, V16, DOI 10.1186/s12906-016-1361-0
   Lv HP, 2017, FOOD RES INT, V100, P486, DOI 10.1016/j.foodres.2016.10.024
   Mao Y, 2017, FOOD RES INT, V99, P641, DOI 10.1016/j.foodres.2017.06.032
   Marino E, 2017, NAT IMMUNOL, V18, P552, DOI 10.1038/ni.3713
   Mei XR, 2016, J AGR FOOD CHEM, V64, P7502, DOI 10.1021/acs.jafc.6b03474
   Ogurtsova K, 2017, DIABETES RES CLIN PR, V128, P40, DOI 10.1016/j.diabres.2017.03.024
   Ou JH, 2013, AM J CLIN NUTR, V98, P111, DOI 10.3945/ajcn.112.056689
   Rizvi SI, 2005, CLIN EXP PHARMACOL P, V32, P70, DOI 10.1111/j.1440-1681.2005.04160.x
   Roopchand DE, 2015, DIABETES, V64, P2847, DOI 10.2337/db14-1916
   Sabu MC, 2002, J ETHNOPHARMACOL, V83, P109
   Sang S., 2010, J SCI FOOD AGR, V86, P2256
   Shi Y, 2017, CELL MOL IMMUNOL, V14, P339, DOI 10.1038/cmi.2016.64
   Teng CuiQin, 2014, Journal of Tea Science, V34, P230
   Tolhurst G, 2012, DIABETES, V61, P364, DOI 10.2337/db11-1019
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Yan HL, 2017, PHYTOMEDICINE, V26, P45, DOI 10.1016/j.phymed.2017.01.007
   Zhang BW, 2018, J FUNCT FOODS, V46, P256, DOI 10.1016/j.jff.2018.04.070
   Zhang JJ, 2014, BIOINFORMATICS, V30, P614, DOI 10.1093/bioinformatics/btt593
   Zhang XQ, 2015, SCI REP-UK, V5, DOI 10.1038/srep10737
   Zhao C, 2018, MOL NUTR FOOD RES, V62, DOI 10.1002/mnfr.201700730
   Zhao LP, 2013, NAT REV MICROBIOL, V11, P639, DOI 10.1038/nrmicro3089
   Zhou XL, 2007, J AGR FOOD CHEM, V55, P5523, DOI 10.1021/jf070699t
NR 46
TC 37
Z9 38
U1 10
U2 84
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD OCT
PY 2019
VL 118
AR 109262
DI 10.1016/j.biopha.2019.109262
PG 7
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA IY4WZ
UT WOS:000486395000084
PM 31376656
OA gold
DA 2023-06-08
ER

PT J
AU Huang, PJ
   Wei, JCC
   Liu, YT
   Lin, CH
   Lin, CC
   Chen, HH
AF Huang, Pei-Ju
   Wei, James Cheng-Chung
   Liu, Yen-Tze
   Lin, Ching-Heng
   Lin, Chi-Chien
   Chen, Hsin-Hua
TI Association between alpha-glucosidase inhibitor use and psoriatic
   disease risk in patients with type 2 diabetes mellitus: A
   population-based cohort study
SO INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
LA English
DT Article
ID GUT MICROBIOTA; PATHOGENESIS; SITAGLIPTIN; ARTHRITIS; ACARBOSE
AB Aims To investigate the association between the use of alpha-glucosidase inhibitors (AGIs) and the risk of psoriatic disease (ie, psoriasis and psoriatic arthritis) in patients with type 2 diabetes mellitus (T2DM) treated with metformin. Methods Using the 1999-2013 Taiwanese Longitudinal Cohort of Diabetes Patients Database, we identified patients with T2DM who initiated hypoglycaemic treatment between 2003 and 2012. After excluding patients with a history of psoriatic disease (International Classification of Disease, Ninth Revision, Clinical Modification codes 696.0-1) before T2DM diagnosis, patients who received antidiabetic treatment for <90 days, and patients aged 100 years, we identified 1390 patients who received metformin+AGIs (AGI exposure group) and 47 514 patients who received metformin only (comparison group). We matched the two groups at a 1:10 ratio by age, sex, and index date of T2DM drug use. The association between AGI use and psoriatic disease risk was analysed using a Cox proportional hazard mode; time-dependent covariates for factors were reported in terms of hazard ratios (HRs) with 95% confidence intervals (CIs) after age, sex, T2DM duration, and comorbidities were controlled for. Results After adjusting the AGI exposure and comparison groups for potential confounders, we found that psoriatic disease risk was associated with metformin+AGI use when AGI was discontinued for 30 days (HR, 8.77; 95% CI, 1.58-48.5) and when a high AGI dose was administered; furthermore, the risk declined during AGI discontinuation. Conclusions This population-based study reports that AGI use and interruption of AGI use may be associated with increased psoriatic disease risk in treated patients with T2DM.
C1 [Huang, Pei-Ju; Wei, James Cheng-Chung; Liu, Yen-Tze] Chung Shan Med Univ, Coll Med, Inst Med, Taichung, Taiwan.
   [Huang, Pei-Ju; Liu, Yen-Tze] Changhua Christian Hosp, Dept Family Med, Changhua, Taiwan.
   [Wei, James Cheng-Chung] Chung Shan Med Univ Hosp, Dept Allergy Immunol & Rheumatol, Taichung, Taiwan.
   [Wei, James Cheng-Chung] China Med Univ, Grad Inst Integrated Med, Taichung, Taiwan.
   [Liu, Yen-Tze] Mingdao Univ, Dept Holist Wellness, Changhua, Taiwan.
   [Lin, Ching-Heng; Chen, Hsin-Hua] Taichung Vet Gen Hosp, Dept Med Res, 1650,Taiwan Blvd Sect 4, Taichung 407204, Taiwan.
   [Lin, Ching-Heng] Natl Taipei Univ Nursing & Hlth Sci, Dept Healthcare Management, Taipei, Taiwan.
   [Lin, Ching-Heng; Chen, Hsin-Hua] Tunghai Univ, Dept Ind Engn & Enterprise Informat, Taichung, Taiwan.
   [Lin, Chi-Chien; Chen, Hsin-Hua] Chung Hsing Univ, Inst Biomed Sci, Taichung, Taiwan.
   [Lin, Chi-Chien; Chen, Hsin-Hua] Chung Hsing Univ, Rong Hsing Res Ctr Translat Med, Taichung, Taiwan.
   [Lin, Chi-Chien; Chen, Hsin-Hua] China Med Univ Hosp, Dept Med Res, Taichung, Taiwan.
   [Chen, Hsin-Hua] Taichung Vet Gen Hosp, Dept Internal Med, Div Allergy Immunol & Rheumatol, Taichung, Taiwan.
   [Chen, Hsin-Hua] Natl Yang Ming Univ, Inst Publ Hlth, Taipei, Taiwan.
   [Chen, Hsin-Hua] Natl Yang Ming Univ, Community Med Res Ctr, Taipei, Taiwan.
C3 Chung Shan Medical University; Changhua Christian Hospital; Chung Shan
   Medical University; Chung Shan Medical University Hospital; China
   Medical University Taiwan; Mingdao University; Taichung Veterans General
   Hospital; National Taipei University of Nursing & Health Science
   (NTUNHS); Tunghai University; National Chung Hsing University; National
   Chung Hsing University; China Medical University Taiwan; China Medical
   University Hospital - Taiwan; Taichung Veterans General Hospital;
   National Yang Ming Chiao Tung University; National Yang Ming Chiao Tung
   University
RP Chen, HH (通讯作者)，Taichung Vet Gen Hosp, Dept Med Res, 1650,Taiwan Blvd Sect 4, Taichung 407204, Taiwan.
EM shc5555@hotmail.com
OI Liu, Yen-Tze/0000-0002-5922-2295
CR Arumugam M, 2011, NATURE, V473, P174, DOI 10.1038/nature09944
   Bischoff SC, 2014, BMC GASTROENTEROL, V14, DOI 10.1186/s12876-014-0189-7
   Boehncke WH, 2015, LANCET, V386, P983, DOI 10.1016/S0140-6736(14)61909-7
   Cao TTB, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.573891
   Chen HH, 2020, MOLECULES, V25, DOI 10.3390/molecules25081822
   Chen HH, 2015, SCI REP-UK, V5, DOI 10.1038/srep18288
   Chen PF, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000021549
   Chen YJ, 2018, EXP DERMATOL, V27, P1336, DOI 10.1111/exd.13786
   Chi CC, 2021, EUR J CLIN INVEST, V51, DOI 10.1111/eci.13377
   Dalmady S, 2020, EXPERT REV CLIN IMMU, V16, P101, DOI 10.1080/1744666X.2019.1700113
   Deleu S, 2021, EBIOMEDICINE, V66, DOI 10.1016/j.ebiom.2021.103293
   Donaldson GP, 2016, NAT REV MICROBIOL, V14, P20, DOI 10.1038/nrmicro3552
   Faurschou A, 2015, J EUR ACAD DERMATOL, V29, P555, DOI 10.1111/jdv.12629
   Gu YY, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-01682-2
   HANEFELD M., 2007, PHARMACOTHERAPY DIAB, P143
   Kamiya K, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20184347
   Khaodhiar L, 1999, Clin Cornerstone, V2, P17, DOI 10.1016/S1098-3597(99)90002-9
   Kim SC, 2015, ANN RHEUM DIS, V74, P1968, DOI 10.1136/annrheumdis-2014-205216
   Kothari V, 2016, J INFLAMM RES, V9, P27, DOI 10.2147/JIR.S86917
   Kridin K, 2018, IMMUNOL RES, V66, P425, DOI 10.1007/s12026-018-9005-8
   Lynch M, 2014, CLIN EXP DERMATOL, V39, P841, DOI 10.1111/ced.12408
   Lynch M, 2016, TRIALS, V17, DOI 10.1186/s13063-016-1157-z
   Masallat D., 2016, African Journal of Microbiology Research, V10, P1337
   Milaneschi Y, 2019, MOL PSYCHIATR, V24, P18, DOI 10.1038/s41380-018-0017-5
   Montandon SA, 2017, GENES-BASEL, V8, DOI 10.3390/genes8100250
   Moore Allan F, 2008, Diabetes Care, V31, pe31, DOI 10.2337/dc08-0230
   National Health Insurance Administration, NATL HLTH INSURANCE
   Nishioka T, 2012, DERMATOLOGY, V224, P20, DOI 10.1159/000333358
   Ogawa E, 2018, J DERMATOL, V45, P264, DOI 10.1111/1346-8138.14139
   Ogdie A, 2015, RHEUM DIS CLIN N AM, V41, P545, DOI 10.1016/j.rdc.2015.07.001
   de Oliveira MDSP, 2015, AN BRAS DERMATOL, V90, P9, DOI 10.1590/abd1806-4841.20153038
   Scher JU, 2015, ARTHRITIS RHEUMATOL, V67, P128, DOI 10.1002/art.38892
   Shapiro J, 2019, J DERMATOL, V46, P595, DOI 10.1111/1346-8138.14933
   Shimazu T, 2009, J THROMB THROMBOLYS, V28, P429, DOI 10.1007/s11239-008-0301-3
   Singh S, 2016, BMC DERMATOL, V16, DOI 10.1186/s12895-016-0049-y
   Su YJ, 2019, J CLIN ENDOCR METAB, V104, P3279, DOI 10.1210/jc.2018-02526
   Sung CT, 2020, J DRUGS DERMATOL, V19, P713, DOI 10.36849/JDD.2020.4874
   Tan LR, 2018, EXP DERMATOL, V27, P144, DOI 10.1111/exd.13463
   Tsuji G, 2020, CELL DEATH DISCOV, V6, DOI 10.1038/s41420-020-0245-8
   Veale DJ, 2018, LANCET, V391, P2273, DOI 10.1016/S0140-6736(18)30830-4
   Weaver GA, 1997, J NUTR, V127, P717, DOI 10.1093/jn/127.5.717
   Wu CY, 2015, J AM ACAD DERMATOL, V72, P123, DOI 10.1016/j.jaad.2014.08.042
   Xu XJ, 2019, DIABETES RES CLIN PR, V150, P167, DOI 10.1016/j.diabres.2019.03.002
   Zhang JZ, 2020, CHINESE MED J-PEKING, V133, P444, DOI 10.1097/CM9.0000000000000642
   Zhang XY, 2017, DIABETES THER, V8, P293, DOI 10.1007/s13300-017-0226-y
NR 45
TC 0
Z9 0
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1368-5031
EI 1742-1241
J9 INT J CLIN PRACT
JI Int. J. Clin. Pract.
PD NOV
PY 2021
VL 75
IS 11
AR e14819
DI 10.1111/ijcp.14819
EA SEP 2021
PG 12
WC Medicine, General & Internal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Pharmacology & Pharmacy
GA WJ4KY
UT WOS:000696210700001
PM 34490702
DA 2023-06-08
ER

PT J
AU Steiner, HE
   Patterson, HK
   Giles, JB
   Karnes, JH
AF Steiner, Heidi E.
   Patterson, Hayley K.
   Giles, Jason B.
   Karnes, Jason H.
TI Bringing pharmacomicrobiomics to the clinic through well-designed
   studies
SO CTS-CLINICAL AND TRANSLATIONAL SCIENCE
LA English
DT Article
ID GUT MICROBIOTA; SAMPLE; COLLECTION; GUIDELINES; METFORMIN; GENETICS;
   IMPACT; TRIALS
AB Pharmacomicrobiomic studies investigate drug-microbiome interactions, such as the effect of microbial variation on drug response and disposition. Studying and understanding the interactions between the gut microbiome and drugs is becoming increasingly relevant to clinical practice due to its potential for avoiding adverse drug reactions or predicting variability in drug response. The highly variable nature of the human microbiome presents significant challenges to assessing microbes' influence. Studies aiming to explore drug-microbiome interactions should be well-designed to account for variation in the microbiome over time and collect data on confounders such as diet, disease, concomitant drugs, and other environmental factors. Here, we assemble a set of important considerations and recommendations for the methodological features required for performing a pharmacomicrobiomic study in humans with a focus on the gut microbiome. Consideration of these factors enable discovery, reproducibility, and more accurate characterization of the relationships between a given drug and the microbiome. Furthermore, appropriate interpretation and dissemination of results from well-designed studies will push the field closer to clinical relevance and implementation.
C1 [Steiner, Heidi E.; Patterson, Hayley K.; Giles, Jason B.; Karnes, Jason H.] Univ Arizona, R Ken Coit Coll Pharm, Dept Pharm Practice & Sci, Tucson, AZ 85721 USA.
   [Karnes, Jason H.] Vanderbilt Univ, Dept Biomed Informat, Med Ctr, Nashville, TN USA.
C3 University of Arizona; Vanderbilt University
RP Karnes, JH (通讯作者)，Univ Arizona, Dept Pharm Practice & Sci, Coll Pharm, 1295 N Martin Ave, Tucson, AZ 85721 USA.
EM karnes@pharmacy.arizona.edu
FU National Heart, Lung, and Blood Institute (NHLBI) [R01HL158686, R01
   HL156993, K01HL143137]; Flinn Foundation; University of Arizona Health
   Science Center
FX National Heart, Lung, and Blood Institute (NHLBI), Grant/Award Number:
   R01HL158686, R01 HL156993 and K01HL143137; Flinn Foundation; University
   of Arizona Health Science Center
CR Anderson EL, 2016, SCI REP-UK, V6, DOI 10.1038/srep31731
   Artacho A, 2021, ARTHRITIS RHEUMATOL, V73, P931, DOI 10.1002/art.41622
   Aziz RK, 2011, BMC BIOINFORMATICS, V12, DOI 10.1186/1471-2105-12-S7-A10
   Azzouz D, 2019, ANN RHEUM DIS, V78, P947, DOI 10.1136/annrheumdis-2018-214856
   Becattini S, 2016, TRENDS MOL MED, V22, P458, DOI 10.1016/j.molmed.2016.04.003
   Beger RD, 2020, METABOLITES, V10, DOI 10.3390/metabo10040129
   Bellali S, 2019, FRONT MICROBIOL, V10, DOI 10.3389/fmicb.2019.01606
   Belle DJ, 2008, AM FAM PHYSICIAN, V77, P1553
   BRAY J. ROGER, 1957, ECOL MONOGR, V27, P325, DOI 10.2307/1942268
   Caporaso JG, 2010, NAT METHODS, V7, P335, DOI 10.1038/nmeth.f.303
   CHAO A, 1984, SCAND J STAT, V11, P265
   Chen RY, 2021, NEW ENGL J MED, V384, P1517, DOI 10.1056/NEJMoa2023294
   Chen YX, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0168618
   Choo JM, 2015, SCI REP-UK, V5, DOI 10.1038/srep16350
   Clayton TA, 2009, P NATL ACAD SCI USA, V106, P14728, DOI 10.1073/pnas.0904489106
   Concato J, 2000, NEW ENGL J MED, V342, P1887, DOI 10.1056/NEJM200006223422507
   Costello EK, 2009, SCIENCE, V326, P1694, DOI 10.1126/science.1177486
   David LA, 2014, NATURE, V505, P559, DOI 10.1038/nature12820
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Debyser G, 2016, J CYST FIBROS, V15, P242, DOI 10.1016/j.jcf.2015.08.003
   Doestzada M, 2018, PROTEIN CELL, V9, P432, DOI 10.1007/s13238-018-0547-2
   Elliott P, 2008, INT J EPIDEMIOL, V37, P234, DOI 10.1093/ije/dym276
   Enright Elaine F., 2016, Yale Journal of Biology and Medicine, V89, P375
   Faith JJ, 2013, SCIENCE, V341, P44, DOI 10.1126/science.1237439
   Flores GE, 2014, GENOME BIOL, V15, DOI 10.1186/s13059-014-0531-y
   Franzosa EA, 2019, NAT MICROBIOL, V4, P293, DOI 10.1038/s41564-018-0306-4
   Franzosa EA, 2018, NAT METHODS, V15, P962, DOI 10.1038/s41592-018-0176-y
   Fraser GE, 2009, EPIDEMIOLOGY, V20, P289, DOI 10.1097/EDE.0b013e31819642c4
   Gilbert JA, 2018, NAT MED, V24, P392, DOI 10.1038/nm.4517
   Goodman B, 2018, J PATHOL, V244, P667, DOI 10.1002/path.5047
   Goodrich JK, 2016, CELL HOST MICROBE, V19, P731, DOI 10.1016/j.chom.2016.04.017
   Goodrich JK, 2014, CELL, V159, P789, DOI 10.1016/j.cell.2014.09.053
   Guo Y, 2013, BMC MED RES METHODOL, V13, DOI 10.1186/1471-2288-13-100
   Haiser HJ, 2013, SCIENCE, V341, P295, DOI 10.1126/science.1235872
   Hannan EL, 2008, JACC-CARDIOVASC INTE, V1, P211, DOI 10.1016/j.jcin.2008.01.008
   Hao ZK, 2020, J AM SOC MASS SPECTR, V31, P1448, DOI 10.1021/jasms.0c00054
   Hildebrand F, 2019, GUT, V68, P1781, DOI 10.1136/gutjnl-2018-317715
   Imhann F, 2018, GUT, V67, P108, DOI 10.1136/gutjnl-2016-312135
   Jackson MA, 2016, GUT, V65, P749, DOI 10.1136/gutjnl-2015-310861
   Jalanka J, 2015, GUT, V64, P1562, DOI 10.1136/gutjnl-2014-307240
   Jernberg C, 2007, ISME J, V1, P56, DOI 10.1038/ismej.2007.3
   Johnson JA, 2011, CLIN PHARMACOL THER, V90, P625, DOI 10.1038/clpt.2011.185
   Johnstone J, 2021, JAMA-J AM MED ASSOC, V326, P1024, DOI 10.1001/jama.2021.13355
   Jovel J, 2016, FRONT MICROBIOL, V7, DOI 10.3389/fmicb.2016.00459
   Kates AE, 2020, FRONT CELL INFECT MI, V10, DOI 10.3389/fcimb.2020.00073
   Kim CS, 2021, JAMA PEDIATR, V175, P303, DOI 10.1001/jamapediatrics.2020.4916
   KRUSKAL JB, 1964, PSYCHOMETRIKA, V29, P1, DOI 10.1007/BF02289565
   Kunz R, 1998, BRIT MED J, V317, P1185, DOI 10.1136/bmj.317.7167.1185
   Lam KN, 2019, CELL HOST MICROBE, V26, P22, DOI 10.1016/j.chom.2019.06.011
   LÁZARO-PACHECO Illce B, 2018, Arq. Gastroenterol., V55, P28, DOI [10.1590/S0004-2803.201800000-09, 10.1590/s0004-2803.201800000-09]
   Lecky DM, 2014, BRIT J GEN PRACT, V64, pE684, DOI 10.3399/bjgp14X682261
   Lee SH, 2018, J CLIN MED, V7, DOI 10.3390/jcm7090282
   Lim MY, 2020, BMC MICROBIOL, V20, DOI 10.1186/s12866-020-01894-5
   Lim MY, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-58719-8
   LOVE MI, 2014, GENOME BIOL, V15, DOI DOI 10.1186/S13059-014-0550-8
   Lozupone C, 2005, APPL ENVIRON MICROB, V71, P8228, DOI 10.1128/AEM.71.12.8228-8235.2005
   Maier L, 2018, NATURE, V555, P623, DOI 10.1038/nature25979
   Matson V, 2018, SCIENCE, V359, P104, DOI 10.1126/science.aao3290
   McDonald D, 2012, ISME J, V6, P610, DOI 10.1038/ismej.2011.139
   Morgan XC, 2012, GENOME BIOL, V13, DOI 10.1186/gb-2012-13-9-r79
   Nagpal R, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.01388
   O'Toole PW, 2015, SCIENCE, V350, P1214, DOI 10.1126/science.aac8469
   Panebianco C, 2018, MICROBIOME, V6, DOI 10.1186/s40168-018-0483-7
   Peirce JM, 2019, J NEUROSCI RES, V97, P1223, DOI 10.1002/jnr.24476
   Peng JT, 2018, LIFE SCI, V214, P153, DOI 10.1016/j.lfs.2018.10.063
   Proctor LM, 2014, CELL HOST MICROBE, V16, P276, DOI 10.1016/j.chom.2014.08.014
   Qian XB, 2020, CHINESE MED J-PEKING, V133, P1844, DOI 10.1097/CM9.0000000000000871
   Rai SN, 2021, GENES DIS, V8, P215, DOI 10.1016/j.gendis.2019.12.005
   Ranjan R, 2016, BIOCHEM BIOPH RES CO, V469, P967, DOI 10.1016/j.bbrc.2015.12.083
   Robinson MD, 2010, BIOINFORMATICS, V26, P139, DOI 10.1093/bioinformatics/btp616
   Roden DM, 2011, CIRCULATION, V123, P1661, DOI 10.1161/CIRCULATIONAHA.109.914820
   Schloss PD, 2009, APPL ENVIRON MICROB, V75, P7537, DOI 10.1128/AEM.01541-09
   Shannon C. E., 1948, BELL SYST TECH J, V27, P379, DOI [10.1002/j.1538-7305.1948.tb01338.x, DOI 10.1002/J.1538-7305.1948.TB00917.X, DOI 10.1002/J.1538-7305.1948.TB01338.X]
   Shim JS, 2014, EPIDEMIOL HEALTH, V36, DOI 10.4178/epih/e2014009
   Sierra MA, 2020, GENES-BASEL, V11, DOI 10.3390/genes11080878
   SIMPSON EH, 1949, NATURE, V163, P688, DOI 10.1038/163688a0
   Sims TT, 2019, GYNECOL ONCOL, V155, P237, DOI 10.1016/j.ygyno.2019.09.002
   Singh RK, 2017, J TRANSL MED, V15, DOI 10.1186/s12967-017-1175-y
   Sinha R, 2016, CANCER EPIDEM BIOMAR, V25, P407, DOI 10.1158/1055-9965.EPI-15-0951
   Spear BB, 2001, TRENDS MOL MED, V7, P201, DOI 10.1016/S1471-4914(01)01986-4
   Srinivasan S, 2022, JAMA NETW OPEN, V5, DOI 10.1001/jamanetworkopen.2022.5032
   Stirratt MJ, 2015, TRANSL BEHAV MED, V5, P470, DOI 10.1007/s13142-015-0315-2
   Subar AF, 2012, J ACAD NUTR DIET, V112, P1134, DOI 10.1016/j.jand.2012.04.016
   Takasuna K, 1996, CANCER RES, V56, P3752
   Tigchelaar EF, 2015, BMJ OPEN, V5, DOI 10.1136/bmjopen-2014-006772
   Tomova A, 2019, FRONT NUTR, V6, DOI 10.3389/fnut.2019.00047
   Valitutti F, 2019, NUTRIENTS, V11, DOI 10.3390/nu11102403
   Videnska P, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-49520-3
   Walker AW, 2011, ISME J, V5, P220, DOI 10.1038/ISMEJ.2010.118
   Wang Z, 2018, FRONT CELL INFECT MI, V8, DOI 10.3389/fcimb.2018.00301
   Wood DE, 2014, GENOME BIOL, V15, DOI 10.1186/gb-2014-15-3-r46
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Wu WK, 2019, J FORMOS MED ASSOC, V118, P545, DOI 10.1016/j.jfma.2018.02.005
   Xia YL, 2017, GENES DIS, V4, P138, DOI 10.1016/j.gendis.2017.06.001
   Yoo DH, 2014, DRUG METAB DISPOS, V42, P1508, DOI 10.1124/dmd.114.058354
   Zhang H, 2011, J APPL STAT, V38, P2373, DOI 10.1080/02664763.2010.550038
   Zhang YY, 2021, APPL MICROBIOL BIOT, V105, P803, DOI 10.1007/s00253-020-11043-7
NR 97
TC 1
Z9 1
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1752-8054
EI 1752-8062
J9 CTS-CLIN TRANSL SCI
JI CTS-Clin. Transl. Sci.
PD OCT
PY 2022
VL 15
IS 10
BP 2303
EP 2315
DI 10.1111/cts.13381
EA AUG 2022
PG 13
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 5M8TJ
UT WOS:000837772600001
PM 35899413
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Ribeiro-Parenti, L
   Cavin, JB
   Le Gall, M
AF Ribeiro-Parenti, Lara
   Cavin, Jean-Baptiste
   Le Gall, Maude
TI Intestinal adaptations following bariatric surgery: towards the
   identification of new pharmacological targets for obesity-related
   metabolic diseases
SO CURRENT OPINION IN PHARMACOLOGY
LA English
DT Article
ID Y GASTRIC BYPASS; GLUCAGON-LIKE PEPTIDE-1; HUMAN GUT MICROBIOTA;
   WEIGHT-LOSS; SLEEVE GASTRECTOMY; GLUCOSE-METABOLISM; BLOOD-GLUCOSE;
   IMPROVEMENT; METFORMIN; RATS
AB Although the gastrointestinal tract is the primary target of bariatric surgery, its contributions to the metabolic changes observed after surgery are still underestimated. Changes in the number of incretin-producing cells could result in the modified hormonal response seen after surgery. Additionally, the rate of absorption and consumption of glucose could contribute to the ameliorated glycaemia. Moreover, decreased intestinal permeability could prevent endotoxemia.Recently, numerous studies have focused on intestinal adaptation following bariatric surgeries. These studies bring new insight into the different roles the GI tract plays in the metabolic outcomes of bariatric surgery and open new avenues for therapeutic treatments.
C1 [Ribeiro-Parenti, Lara; Cavin, Jean-Baptiste; Le Gall, Maude] Univ Paris Diderot, Sorbonne Paris Cite, DHU Unity APHP, UFR Med Paris Diderot,Inserm UMR 1149, F-75890 Paris, France.
   [Cavin, Jean-Baptiste] Univ Calgary, Hotchkiss Brain Inst, Dept Physiol & Pharmacol, Calgary, AB T2N 4N1, Canada.
C3 Assistance Publique Hopitaux Paris (APHP); Institut National de la Sante
   et de la Recherche Medicale (Inserm); UDICE-French Research
   Universities; Universite Paris Cite; University of Calgary
RP Le Gall, M (通讯作者)，Univ Paris Diderot, Sorbonne Paris Cite, DHU Unity APHP, UFR Med Paris Diderot,Inserm UMR 1149, F-75890 Paris, France.
EM Maude.le-gall@inserm.fr
RI Le Gall, Maude/W-2593-2019; Le Gall, Maude/C-3917-2017
OI Le Gall, Maude/0000-0002-5372-4585; Le Gall, Maude/0000-0002-5372-4585
FU Inserm, University Paris Diderot; Fondation pour la Recherche Medicale;
   Afero; Societe Francophone du Diabete; SFNEP; Institut Benjamin
   Delessert
FX This work was supported by Inserm, University Paris Diderot. LRP
   received funding from the Fondation pour la Recherche Medicale, JBC
   received funding from Afero and the Prix Claude Roze, MLG received
   funding from Societe Francophone du Diabete, SFNEP and Institut Benjamin
   Delessert.
CR Albaugh VL, 2017, MOL ASPECTS MED, V56, P75, DOI 10.1016/j.mam.2017.04.001
   Aranias T, 2015, J NUTR SCI, V4, DOI 10.1017/jns.2015.11
   Bahler L, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0176242
   Bahler L, 2016, DIABETES RES CLIN PR, V114, P55, DOI 10.1016/j.diabres.2016.02.009
   Batterham RL, 2016, DIABETES CARE, V39, P893, DOI 10.2337/dc16-0145
   Baud G, 2016, CELL METAB, V23, P547, DOI 10.1016/j.cmet.2016.01.018
   Benjamin MA, 2000, GUT, V47, P112, DOI 10.1136/gut.47.1.112
   Bhutta HY, 2014, AM J PHYSIOL-GASTR L, V307, pG588, DOI 10.1152/ajpgi.00405.2013
   Billiauws L, 2017, EXPERT OPIN BIOL TH, V17, P623, DOI 10.1080/14712598.2017.1304912
   Blanchard C, 2017, OBES SURG
   Brown DX, 2012, J NUTR METAB, V2012, DOI 10.1155/2012/381713
   Buse JB, 2016, DIABETES CARE, V39, P198, DOI 10.2337/dc15-0488
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   Casselbrant A, 2015, SURG OBES RELAT DIS, V11, P45, DOI 10.1016/j.soard.2014.05.009
   Cavin JB, 2016, AM J PHYSIOL-GASTR L, V311, pG492, DOI 10.1152/ajpgi.00197.2016
   Cavin JB, 2016, GASTROENTEROLOGY, V150, P454, DOI 10.1053/j.gastro.2015.10.009
   Chambers AP, 2014, AM J PHYSIOL-ENDOC M, V306, pE424, DOI 10.1152/ajpendo.00469.2013
   Clemente-Postigo M, 2015, SURG OBES RELAT DIS, V11, P933, DOI 10.1016/j.soard.2014.11.030
   Cummings David E., 2004, Journal of Clinical Endocrinology & Metabolism, V89, P2608, DOI 10.1210/jc.2004-0433
   Dusaulcy R, 2016, ENDOCRINOLOGY, V157, P536, DOI 10.1210/en.2015-1725
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Finan B, 2015, NAT MED, V21, P27, DOI 10.1038/nm.3761
   Furet JP, 2010, DIABETES, V59, P3049, DOI 10.2337/db10-0253
   Ghani U, 2015, EUR J MED CHEM, V103, P133, DOI 10.1016/j.ejmech.2015.08.043
   Gontier E, 2008, EUR J NUCL MED MOL I, V35, P95, DOI 10.1007/s00259-007-0563-6
   Gupta S, 2016, THER ADV GASTROENTER, V9, P229, DOI 10.1177/1756283X15607414
   Hansen CF, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0065696
   le Roux CW, 2010, ANN SURG, V252, P50, DOI 10.1097/SLA.0b013e3181d3d21f
   Liou AP, 2013, SCI TRANSL MED, V5, DOI 10.1126/scitranslmed.3005687
   Magkos F, 2016, AM J CLIN NUTR, V103, P61, DOI 10.3945/ajcn.115.116111
   Mahawar KK, 2017, OBES SURG
   McCreight LJ, 2016, DIABETOLOGIA, V59, P426, DOI 10.1007/s00125-015-3844-9
   Meek CL, 2016, PEPTIDES, V77, P28, DOI 10.1016/j.peptides.2015.08.013
   Miyachi T, 2016, SURGERY, V159, P1360, DOI 10.1016/j.surg.2015.11.027
   Mumphrey MB, 2013, NEUROGASTROENT MOTIL, V25, pE70, DOI 10.1111/nmo.12034
   Mumphrey MB, 2015, OBES SURG, V25, P1468, DOI 10.1007/s11695-014-1547-9
   Nergard BJ, 2015, SURG OBES RELAT DIS, V11, P1237, DOI 10.1016/j.soard.2015.03.021
   Nguyen NQ, 2014, OBESITY, V22, P2164, DOI 10.1002/oby.20829
   PENICAUD L, 1989, BIOCHEM J, V262, P881, DOI 10.1042/bj2620881
   Plovier H, 2017, NAT MED, V23, P107, DOI 10.1038/nm.4236
   Psichas A, 2015, J CLIN INVEST, V125, P908, DOI 10.1172/JCI76309
   Romero F, 2012, SURG ENDOSC, V26, P2231, DOI 10.1007/s00464-012-2166-y
   Saeidi N, 2013, SCIENCE, V341, P406, DOI 10.1126/science.1235103
   Salehi M, 2014, REV ENDOCR METAB DIS, V15, P171, DOI 10.1007/s11154-014-9291-y
   Savassi-Rocha AL, 2014, OBES SURG, V24, P184, DOI 10.1007/s11695-013-1084-y
   Schmitt CC, 2017, MOL METAB, V6, P61, DOI 10.1016/j.molmet.2016.10.008
   Stearns AT, 2009, AM J PHYSIOL-GASTR L, V297, pG950, DOI 10.1152/ajpgi.00253.2009
   Sweeney TE, 2014, BEST PRACT RES CL GA, V28, P727, DOI 10.1016/j.bpg.2014.07.016
   Taqia E, 2010, J PEDIATR SURG, V45, P987, DOI 10.1016/j.jpedsurg.2010.02.036
   Tremaroli V, 2015, CELL METAB, V22, P228, DOI 10.1016/j.cmet.2015.07.009
   Tschop MH, 2016, CELL METAB, V24, P51, DOI 10.1016/j.cmet.2016.06.021
   Vrieze A, 2012, GASTROENTEROLOGY, V143, P913, DOI 10.1053/j.gastro.2012.06.031
   Zachos NC, 2016, J BIOL CHEM, V291, P3759, DOI 10.1074/jbc.R114.635995
   Zhang HS, 2009, P NATL ACAD SCI USA, V106, P2365, DOI 10.1073/pnas.0812600106
   Zietek T, 2015, SCI REP-UK, V5, DOI 10.1038/srep16831
NR 55
TC 4
Z9 4
U1 3
U2 9
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1471-4892
EI 1471-4973
J9 CURR OPIN PHARMACOL
JI Curr. Opin. Pharmacol.
PD DEC
PY 2017
VL 37
BP 29
EP 34
DI 10.1016/j.coph.2017.08.002
PG 6
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA FR9WK
UT WOS:000419423700007
PM 28822847
DA 2023-06-08
ER

PT J
AU Smits, MM
   Tonneijck, L
   Muskiet, MHA
   Hoekstra, T
   Kramer, MHH
   Diamant, M
   Nieuwdorp, M
   Groen, AK
   Cahen, DL
   van Raalte, DH
AF Smits, Mark M.
   Tonneijck, Lennart
   Muskiet, Marcel H. A.
   Hoekstra, Trynke
   Kramer, Mark H. H.
   Diamant, Michaela
   Nieuwdorp, Max
   Groen, Albert K.
   Cahen, Djuna L.
   van Raalte, Daniel H.
TI Biliary effects of liraglutide and sitagliptin, a 12-week randomized
   placebo-controlled trial in type 2 diabetes patients
SO DIABETES OBESITY & METABOLISM
LA English
DT Article
DE bile acids; dipeptidyl peptidase 4; DPP-4; gallbladder emptying; gastric
   emptying; glucagon-like peptide 1; GLP-1
ID GALLBLADDER; METFORMIN; SAFETY; SODIUM
AB AimsTreatment with glucagon-like peptide (GLP)-1 receptor agonists or dipeptidyl peptidase (DPP)-4 inhibitors might increase gallstone formation; however, the mechanisms involved are unknown. We aimed to assess the effects of these drugs on gallbladder volume and bile acid profile.
   Materials and methodsA total of 57 type 2 diabetes patients (meanSD age, 62.86.9years; BMI, 31.8 +/- 4.1kg/m(2); HbA1c, 7.3%+/- 0.6%), treated with metformin and/or sulfonylureas, were included in this 12-week randomized, placebo-controlled, double-blind, single-centre trial between July 2013 and August 2015 at the VU University Medical Center, the Netherlands. Patients received the GLP-1 receptor agonist liraglutide, the DPP-4 inhibitor sitagliptin or matching placebo for 12weeks. Gallbladder fasting volume and ejection fraction were measured using ultrasonography after a high-fat meal. Serum bile acids were measured in the fasting and postprandial state and in faecal samples. The trial was registered at (NCT01744236).
   Results Neither liraglutide nor sitagliptin had an effect on gallbladder fasting volume and ejection fraction (p>.05). Liraglutide increased serum levels of deoxycholic acid in the fasting state [0.20 mu mol/L (95% CI 0.027-0.376), p=0.024] and postprandial state [AUC 40.71 (13.22-68.21), p=0.005] and in faeces [ratio 1.5 (1.03-2.19); p=0.035]. Sitagliptin had no effect on serum bile acids, but increased faecal levels of chenodeoxycholic acid [ratio 3.42 (1.33-8.79), p=0.012], cholic acid [ratio 3.32 (1.26-8.87), p=0.017] and ursodeoxycholic acid [ratio 3.81 (1.44-10.14), p=0.008].
   Conclusions Neither liraglutide nor sitagliptin has an effect on gallbladder volume. Observed changes in bile acids with liraglutide suggest alterations in the intestinal microbiome, while sitagliptin appears to increase hepatic bile acid production.
C1 [Smits, Mark M.; Tonneijck, Lennart; Muskiet, Marcel H. A.; Kramer, Mark H. H.; Diamant, Michaela; Nieuwdorp, Max; van Raalte, Daniel H.] Vrije Univ Amsterdam Med Ctr, Dept Internal Med, Ctr Diabet, Boelelaan 1117 Room ZH 4A65, NL-1081 HV Amsterdam, Netherlands.
   [Hoekstra, Trynke] Vrije Univ Amsterdam, Dept Hlth Sci, Amsterdam, Netherlands.
   [Hoekstra, Trynke] Vrije Univ Amsterdam, EMGO Inst Hlth & Care Res, Amsterdam, Netherlands.
   [Hoekstra, Trynke] Vrije Univ Amsterdam Med Ctr, Dept Epidemiol & Biostat, Amsterdam, Netherlands.
   [Nieuwdorp, Max; Groen, Albert K.] Acad Med Ctr, Dept Vasc Med, Amsterdam, Netherlands.
   [Nieuwdorp, Max] Univ Gothenberg, Wallenberg Lab, Gothenburg, Sweden.
   [Groen, Albert K.] Univ Groningen, Univ Med Ctr Groningen, Lab Metab Dis, Dept Pediat, Groningen, Netherlands.
   [Cahen, Djuna L.] Erasmus MC, Dept Gastroenterol & Hepatol, Rotterdam, Netherlands.
C3 Vrije Universiteit Amsterdam; VU UNIVERSITY MEDICAL CENTER; Vrije
   Universiteit Amsterdam; Vrije Universiteit Amsterdam; Vrije Universiteit
   Amsterdam; VU UNIVERSITY MEDICAL CENTER; University of Amsterdam;
   Academic Medical Center Amsterdam; University of Gothenburg; University
   of Groningen; Erasmus University Rotterdam; Erasmus MC
RP Smits, MM (通讯作者)，Vrije Univ Amsterdam Med Ctr, Dept Internal Med, Ctr Diabet, Boelelaan 1117 Room ZH 4A65, NL-1081 HV Amsterdam, Netherlands.
EM mm.smits1@vumc.nl
RI Smits, Mark/E-6573-2014; cahen, djuna/AAC-4037-2020; Kramer,
   Mark/GWQ-3502-2022; Hoekstra, Trynke/AAG-5901-2020
OI Smits, Mark/0000-0001-8236-8842; Hoekstra, Trynke/0000-0002-0535-0056;
   van Raalte, Daniel/0000-0003-2894-6124; Muskiet,
   Marcel/0000-0003-4116-555X
FU European Community [282521]
FX The research leading to these results was funded in part by the European
   Community's Seventh Framework Programme (FP7/2007-2013), under grant
   agreement no 282521 - the SAFEGUARD project. Novo Nordisk kindly
   provided pre-filled liraglutide and liraglutide-placebo pens. The
   researchers were independent from the funders. The funders had no role
   in study design; in the collection, analysis, and interpretation of
   data; in the writing of the report; nor in the decision to submit the
   article for publication.
CR Bastouly M, 2009, OBES SURG, V19, P22, DOI 10.1007/s11695-008-9648-y
   Ben Shlomo S, 2013, DIGEST DIS SCI, V58, P172, DOI 10.1007/s10620-012-2353-7
   CARULLI N, 1984, J CLIN INVEST, V74, P614, DOI 10.1172/JCI111459
   Davidson MH, 2007, AM J CARDIOL, V99, p3C, DOI 10.1016/j.amjcard.2006.11.016
   Devkota S, 2013, NATURE, V499, P37, DOI 10.1038/nature12404
   DODDS WJ, 1985, AM J ROENTGENOL, V145, P1009, DOI 10.2214/ajr.145.5.1009
   Glerup H, 2007, SCAND J GASTROENTERO, V42, P1182, DOI 10.1080/00365520701370922
   Gutzwiller JP, 2006, DIGESTION, V73, P142, DOI 10.1159/000094334
   Hodge RJ, 2013, CLIN PHARM DRUG DEV, V2, P213, DOI 10.1002/cpdd.34
   Jinnouchi H, 2015, J DIABETES RES, V2015, DOI 10.1155/2015/706416
   Keller J, 2012, REGUL PEPTIDES, V179, P77, DOI 10.1016/j.regpep.2012.08.005
   Korkmaz H, 2015, AGING CLIN EXP RES, V27, P751, DOI 10.1007/s40520-015-0335-2
   Kuipers F, 2014, NAT REV ENDOCRINOL, V10, P488, DOI 10.1038/nrendo.2014.60
   Marso SP, 2016, NEW ENGL J MED, V375, P311, DOI 10.1056/NEJMoa1603827
   McCreight LJ, 2016, DIABETOLOGIA, V59, P426, DOI 10.1007/s00125-015-3844-9
   MEKHJIAN HS, 1971, J CLIN INVEST, V50, P1569, DOI 10.1172/JCI106644
   Muskiet MHA, 2016, DIABETES OBES METAB, V18, P178, DOI 10.1111/dom.12601
   Napolitano A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100778
   Nunez DJ, 2016, DIABETES OBES METAB, V18, P654, DOI 10.1111/dom.12656
   Pi-Sunyer X, 2015, NEW ENGL J MED, V373, P11, DOI 10.1056/NEJMoa1411892
   Pizzimenti V, 2016, J CLIN PHARM THER, V41, P116, DOI 10.1111/jcpt.12373
   Pratley RE, 2010, LANCET, V375, P1447, DOI 10.1016/S0140-6736(10)60307-8
   Sari R, 2003, J CLIN ULTRASOUND, V31, P352, DOI 10.1002/jcu.10191
   Schaap FG, 2014, NAT REV GASTRO HEPAT, V11, P55, DOI 10.1038/nrgastro.2013.151
   Smits MM, 2016, GUT, V65, P702, DOI 10.1136/gutjnl-2015-310572
   Smits MM, 2015, BMJ OPEN, V5, DOI 10.1136/bmjopen-2015-009579
   STONE BG, 1988, GASTROENTEROLOGY, V95, P170, DOI 10.1016/0016-5085(88)90307-1
   van Can J, 2014, INT J OBESITY, V38, P784, DOI 10.1038/ijo.2013.162
   van Meer H, 2008, AM J PHYSIOL-GASTR L, V294, pG540, DOI 10.1152/ajpgi.00396.2007
   Vrieze A, 2014, J HEPATOL, V60, P824, DOI 10.1016/j.jhep.2013.11.034
NR 30
TC 35
Z9 35
U1 0
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1462-8902
EI 1463-1326
J9 DIABETES OBES METAB
JI Diabetes Obes. Metab.
PD DEC
PY 2016
VL 18
IS 12
BP 1217
EP 1225
DI 10.1111/dom.12748
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EC1EQ
UT WOS:000387847100007
PM 27451030
OA Green Published, hybrid
DA 2023-06-08
ER

PT J
AU Wu, CM
   Zhao, Y
   Zhang, YY
   Yang, YN
   Su, WQ
   Yang, YY
   Sun, L
   Zhang, F
   Yu, JQ
   Wang, YX
   Guo, P
   Zhu, BL
   Wu, SX
AF Wu, Chongming
   Zhao, Ying
   Zhang, Yingying
   Yang, Yanan
   Su, Wenquan
   Yang, Yuanyuan
   Sun, Le
   Zhang, Fang
   Yu, Jiaqi
   Wang, Yaoxian
   Guo, Peng
   Zhu, Baoli
   Wu, Shengxian
TI Gut microbiota specifically mediates the anti-hypercholesterolemic
   effect of berberine (BBR) and facilitates to predict BBR's
   cholesterol-decreasing efficacy in patients
SO JOURNAL OF ADVANCED RESEARCH
LA English
DT Article
DE Gut microbiota; Berberine (BBR); Hyperlipidemia; Hypercholesterolemia;
   Inter-individual response variation; Blautia; Alistipes
ID AKKERMANSIA-MUCINIPHILA; INSULIN-RESISTANCE; LIPID-METABOLISM;
   INHIBITION; MECHANISM; METFORMIN; KINASE
AB Introduction: Gut microbiota has been implicated in the pharmacological activities of many natural prod-ucts. As an effective hypolipidemic agent, berberine (BBR)'s clinical application is greatly impeded by the obvious inter-individual response variation. To date, little evidence exists on the causality between gut microbes and its therapeutic effects, and the linkage of bacteria alterations to the inter-individual response variation. Objectives: This study aims to confirm the causal role of the gut microbiota in BBR's anti-hyperlipidemic effect and identify key bacteria that can predict its effectiveness. Methods: The correlation between gut microbiota and BBR's inter-individual response variation was studied in hyperlipidemic patients. The causal role of gut microbes in BBR's anti-hyperlipidemic effects was subsequently assessed by altered administration routes, co-treatment with antibiotics, fecal micro-biota transplantation, and metagenomic analysis. Results: Three-month clinical study showed that BBR was effectively to decrease serum lipids but displayed an obvious response variation. The cholesterol-lowering but not triglyceride-decreasing effect of BBR was closely related to its modulation on gut microbiota. Interestingly, the baseline levels of Alistipes and Blautia could accurately predict its anti-hypercholesterolemic efficiency in the following treatment. Causality experiments in mice further confirmed that the gut microbiome is both necessary and sufficient to mediate the lipid-lowering effect of BBR. The absence of Blautia substantially abolished BBR's cholesterol-decreasing efficacy. Conclusion: The gut microbiota is necessary and sufficient for BBR's hyperlipidemia-ameliorating effect. The baseline composition of gut microbes can be an effective predictor for its pharmacotherapeutic efficacy, providing a novel way to achieve personalized therapy. (c) 2022 The Authors. Published by Elsevier B.V. on behalf of Cairo University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
C1 [Wu, Chongming; Yang, Yanan; Sun, Le; Zhang, Fang; Yu, Jiaqi; Guo, Peng] Inst Med Plant Dev, Pharmacol & Toxicol Res Ctr, Chinese Acad Med Sci & Peking Union Med Coll, Beijing 100193, Peoples R China.
   [Zhang, Yingying; Su, Wenquan; Yang, Yuanyuan; Wang, Yaoxian; Wu, Shengxian] Beijing Univ Chinese Med, Dongzhimen Hosp, Beijing 100700, Peoples R China.
   [Zhu, Baoli] Inst Microbiol, Chinese Acad Sci, CAS Key Lab Pathogen Microbiol & Immunol, Beijing 100101, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Institute of Medicinal Plant Development - CAMS; Peking Union Medical
   College; Beijing University of Chinese Medicine; Chinese Academy of
   Sciences
RP Wu, CM; Guo, P (通讯作者)，Inst Med Plant Dev, Pharmacol & Toxicol Res Ctr, Chinese Acad Med Sci & Peking Union Med Coll, Beijing 100193, Peoples R China.; Wu, SX (通讯作者)，Beijing Univ Chinese Med, Dongzhimen Hosp, Beijing 100700, Peoples R China.; Zhu, BL (通讯作者)，Inst Microbiol, Chinese Acad Sci, CAS Key Lab Pathogen Microbiol & Immunol, Beijing 100101, Peoples R China.
EM cmwu@implad.ac.cn; pguo@implad.ac.cn; zhubaoli@im.ac.cn; wushx@sina.com
RI yang, yuanyuan/HPG-2020-2023; Wu, Chongming/GOJ-9081-2022
FU National Natural Science Foundation of China [81673663, 81973217];
   Nonprofit Central Research Institute Fund of Chinese Academy of Medical
   Sciences [2018RC350014]; CAMS Innovation Fund for Medical Sciences
   (CIFMS) [2016-I2M-3-015]; National Major Scientific and Technological
   Special Project for ``Significant New Drugs Development"
   [2017ZX09304019]
FX This work was supported financially by the National Natural Science
   Foundation of China (81673663, 81973217), the Nonprofit Central Research
   Institute Fund of Chinese Academy of Medical Sciences (2018RC350014),
   CAMS Innovation Fund for Medical Sciences (CIFMS) 2016-I2M-3-015, and
   National Major Scientific and Technological Special Project for
   ``Significant New Drugs Development"(No.2017ZX09304019).
CR Anhe FF, 2015, GUT, V64, P872, DOI 10.1136/gutjnl-2014-307142
   Bhatt AP, 2020, P NATL ACAD SCI USA, V117, P7374, DOI 10.1073/pnas.1918095117
   Brusq JM, 2006, J LIPID RES, V47, P1281, DOI 10.1194/jlr.M600020-JLR200
   Chang CJ, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms8489
   Collins SL, 2020, ACTA PHARMACOL SIN B, V10, P19, DOI 10.1016/j.apsb.2019.12.001
   Daly K, 2012, BRIT J NUTR, V107, P989, DOI 10.1017/S0007114511003825
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Elbere I, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0241338
   Feng XJ, 2019, THERANOSTICS, V9, P1923, DOI 10.7150/thno.30787
   Ilyas Z, 2020, BIOMED PHARMACOTHER, V127, DOI 10.1016/j.biopha.2020.110137
   Imenshahidi M, 2016, PHYTOTHER RES, V30, P1745, DOI 10.1002/ptr.5693
   Joyner MJ, 2019, J CLIN INVEST, V129, P946, DOI 10.1172/JCI126119
   Kahn SE, 2006, NEW ENGL J MED, V355, P2427, DOI 10.1056/NEJMoa066224
   Kleiner DE, 2015, GASTROENTEROLOGY, V149, P1305, DOI 10.1053/j.gastro.2015.09.015
   Kong WJ, 2020, PHARMACOL THERAPEUT, V209, DOI 10.1016/j.pharmthera.2020.107496
   Kong WJ, 2009, METABOLISM, V58, P109, DOI 10.1016/j.metabol.2008.08.013
   Kong WJ, 2004, NAT MED, V10, P1344, DOI 10.1038/nm1135
   Kreutz R, 2004, CURR HYPERTENS REP, V6, P15, DOI 10.1007/s11906-004-0005-9
   Morand C, 2020, P NUTR SOC, V79, P225, DOI 10.1017/S0029665120000014
   Ozato N, 2019, NPJ BIOFILMS MICROBI, V5, DOI 10.1038/s41522-019-0101-x
   Roopchand DE, 2015, DIABETES, V64, P2847, DOI 10.2337/db14-1916
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Soccio RE, 2015, CELL, V162, P33, DOI 10.1016/j.cell.2015.06.025
   Sun RB, 2017, MOL PHARMACOL, V91, P110, DOI 10.1124/mol.116.106617
   Tan XS, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0077969
   Tian Y, 2019, DRUG METAB DISPOS, V47, P86, DOI 10.1124/dmd.118.083691
   Tong XL, 2018, MBIO, V9, DOI 10.1128/mBio.02392-17
   Tsimihodimos V, 2018, DIABETES RES CLIN PR, V137, P1, DOI 10.1016/j.diabres.2017.12.012
   Turnbaugh PJ, 2009, NATURE, V457, P480, DOI 10.1038/nature07540
   Wang LJ, 2018, LIPIDS HEALTH DIS, V17, DOI 10.1186/s12944-018-0801-x
   Wang Y, 2017, THERANOSTICS, V7, P2443, DOI 10.7150/thno.18290
   Wang Y, 2017, METABOLISM, V70, P72, DOI 10.1016/j.metabol.2017.02.003
   Wu CM, 2019, PHYTOMEDICINE, V58, DOI 10.1016/j.phymed.2019.152863
   Wu CM, 2014, J NUTR BIOCHEM, V25, P412, DOI 10.1016/j.jnutbio.2013.12.002
   Xu XM, 2021, BIOMED PHARMACOTHER, V133, DOI 10.1016/j.biopha.2020.110984
   Xu YJ, 2019, J TRANSL MED, V17, DOI 10.1186/s12967-019-2010-4
   Zhang H, 2010, METABOLISM, V59, P285, DOI 10.1016/j.metabol.2009.07.029
   Zhang X, 2012, PLOS ONE, V7, DOI [10.1371/journal.pone.0040320, 10.1371/journal.pone.0042529]
   Zhang X, 2015, SCI REP-UK, V5, DOI 10.1038/srep14405
   Zhang YX, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-16034-w
   Zhang ZG, 2014, NAT COMMUN, V5, DOI 10.1038/ncomms6493
   Zhu L, 2018, ATHEROSCLEROSIS, V268, P117, DOI 10.1016/j.atherosclerosis.2017.11.023
   Zhu WD, 2019, CIRC RES, V124, P539, DOI 10.1161/CIRCRESAHA.118.314050
NR 43
TC 19
Z9 19
U1 13
U2 38
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2090-1232
EI 2090-1224
J9 J ADV RES
JI J. Adv. Res.
PD MAR
PY 2022
VL 37
BP 197
EP 208
DI 10.1016/j.jare.2021.07.011
EA MAR 2022
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 0A0EU
UT WOS:000773635800006
PM 35499044
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Nallappan, D
   Chua, KH
   Ong, KC
   Chong, CW
   Teh, CSJ
   Palanisamy, UD
   Kuppusamy, UR
AF Nallappan, Devi
   Chua, Kek Heng
   Ong, Kien Chai
   Chong, Chun Wie
   Teh, Cindy Shuan Ju
   Palanisamy, Uma Devi
   Kuppusamy, Umah Rani
TI Amelioration of high-fat diet-induced obesity and its associated
   complications by a myricetin derivative-rich fraction from Syzygium
   malaccense in C57BL/6J mice
SO FOOD & FUNCTION
LA English
DT Article
ID INDUCED OXIDATIVE STRESS; GUT MICROBIOTA; INSULIN-RESISTANCE; INTESTINAL
   MICROBIOTA; PREVENTS OBESITY; BLOOD-GLUCOSE; ANTIOXIDANT; HYPERGLYCEMIA;
   INFLAMMATION; EXTRACT
AB Obesity is a driving factor in the onset of metabolic disorders. This study aims to investigate the effects of the myricetin derivative-rich fraction (MD) from Syzygium malaccense leaf extract on high-fat diet (HFD)-induced obesity and its associated complications and its influence on uncoupling protein-1 (UCP-1) and gut microbiota in C57BL/6J mice. Mice were randomly assigned into four groups (n = 6) and given a normal diet (ND) or high-fat diet (HFD) for 10 weeks to induce obesity. The HFD groups (continued with HFD) were administered 50 mg kg(-1) MD (treatment), 50 mg kg(-1) metformin (positive control) and normal saline (HFD and ND controls) daily for four weeks via oral gavage. The ten-week HFD-feeding resulted in hyperglycemia and elevated urinary oxidative indices. The subsequent MD administration caused significant weight reduction without appetite suppression and amelioration of insulin resistance, steatosis and dyslipidemia. Besides, MD significantly reduced lipid hydroperoxides and protein carbonyls in tissue homogenates and urine and elevated Trolox equivalent antioxidant capacity (TEAC), ferric reducing antioxidant power (FRAP) and reduced glutathione (GSH) and thus, alleviated oxidative stress. The weight reduction was correlated with downregulation of inflammatory markers and the increased UCP-1 level, suggesting weight loss plausibly through thermogenesis. The Akkermansia genus (reflects improved metabolic status) in the HFD50 group was more abundant than that in the HFD group while the non-enzymatic antioxidant markers were strongly associated with UCP-1. In conclusion, MD ameliorates obesity and its related complications possibly via the upregulation of UCP-1 and increased abundance of Akkermansia genus and is promising as a therapeutic agent in the treatment of obesity and its associated metabolic disorders.
C1 [Nallappan, Devi; Chua, Kek Heng; Ong, Kien Chai; Kuppusamy, Umah Rani] Univ Malaya, Dept Biomed Sci, Fac Med, Kuala Lumpur 50603, Malaysia.
   [Ong, Kien Chai] Univ Malaya, Inst Res Management Monitoring, Lab Anim Ctr, Ctr Res Serv, Kuala Lumpur 50603, Malaysia.
   [Chong, Chun Wie] Monash Univ Malaysia, CSchool Pharm, Bandar Sunway 47500, Selangor, Malaysia.
   [Teh, Cindy Shuan Ju] Univ Malaya, Dept Med Microbiol, Fac Med, Kuala Lumpur 50603, Malaysia.
   [Palanisamy, Uma Devi] Monash Univ Malaysia, Jeffrey Cheah Sch Med & Hlth Sci, Bandar Sunway 47500, Selangor, Malaysia.
C3 Universiti Malaya; Universiti Malaya; Monash University; Monash
   University Sunway; Universiti Malaya; Monash University; Monash
   University Sunway
RP Kuppusamy, UR (通讯作者)，Univ Malaya, Dept Biomed Sci, Fac Med, Kuala Lumpur 50603, Malaysia.
EM umah@um.edu.my
RI CHUA, KEK HENG/B-5261-2010; KUPPUSAMY, UMAH RANI/B-9981-2010; Chong,
   Chun Wie/ABG-7676-2020; ONG, KIEN CHAI/B-9452-2010; Nallappan,
   Devi/GLQ-7177-2022; Teh, Cindy/D-7161-2019; Chong, Chun Wie/E-2909-2010
OI CHUA, KEK HENG/0000-0002-0452-9994; Chong, Chun Wie/0000-0002-6881-8883;
   Teh, Cindy/0000-0002-9062-3839; Chong, Chun Wie/0000-0002-6881-8883;
   Nallappan, Devi/0000-0003-2673-5614
FU Fundamental Research Grant Scheme, Ministry of Higher Education,
   Malaysia [FP012-2016]
FX This study was financially supported by the Fundamental Research Grant
   Scheme, Ministry of Higher Education, Malaysia (FP012-2016).
CR Akindehin S, 2018, NUTRIENTS, V10, DOI 10.3390/nu10121962
   Al-Goblan AS, 2014, DIABETES METAB SYNDR, V7, P587, DOI 10.2147/DMSO.S67400
   Arumugam B, 2020, J FUNCT FOODS, V67, DOI 10.1016/j.jff.2020.103844
   Arumugam B, 2016, J FUNCT FOODS, V22, P325, DOI 10.1016/j.jff.2016.01.038
   Arumugam B, 2014, LWT-FOOD SCI TECHNOL, V59, P707, DOI 10.1016/j.lwt.2014.06.041
   Avtanski D, 2019, ANIM MODEL EXP MED, V2, P252, DOI 10.1002/ame2.12084
   Bai YF, 2019, NUTR DIABETES, V9, DOI 10.1038/s41387-019-0097-6
   Bairy K. L., 2005, Journal of Natural Remedies, V5, P46
   Barbosa Wagner Luiz R., 2006, Rev. bras. farmacogn., V16, P333, DOI 10.1590/S0102-695X2006000300009
   Batista AG, 2017, LWT-FOOD SCI TECHNOL, V76, P284, DOI 10.1016/j.lwt.2016.05.013
   Bryrup T, 2019, DIABETOLOGIA, V62, P1024, DOI 10.1007/s00125-019-4848-7
   Busiello RA, 2015, FRONT PHYSIOL, V6, DOI 10.3389/fphys.2015.00036
   Chandramathi S, 2009, J CANCER RES CLIN, V135, P319, DOI 10.1007/s00432-008-0462-7
   Chen L, 2015, INT J ENDOCRINOL, V2015, DOI 10.1155/2015/508409
   Choi BK, 2016, ASIAN PAC J TROP MED, V9, P616, DOI 10.1016/j.apjtm.2016.05.017
   Chung E, 2020, NUTR RES, V77, P97, DOI 10.1016/j.nutres.2020.04.001
   Collins SL, 2020, ACTA PHARMACOL SIN B, V10, P19, DOI 10.1016/j.apsb.2019.12.001
   Cuevas-Ramos D, 2019, FRONT PHYSIOL, V10, DOI 10.3389/fphys.2019.00037
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   de Wilde J, 2009, J NUTRIGENET NUTRIGE, V2, P280, DOI 10.1159/000308466
   ESTERBAUER H, 1990, METHOD ENZYMOL, V186, P407
   Ghandi S, 2011, J ASSIST REPROD GEN, V28, P591, DOI 10.1007/s10815-011-9564-2
   Gholamian-Dehkordi N, 2017, IMMUNOPATHOL PERSA, V3, DOI 10.15171/ipp.2017.04
   Gloor GB, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.02224
   Gu LP, 2019, INT J BIOL SCI, V15, P2815, DOI 10.7150/ijbs.31781
   Hamza N, 2011, J ETHNOPHARMACOL, V133, P931, DOI 10.1016/j.jep.2010.11.019
   He C, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.00639
   Hill James O, 2013, Eur Endocrinol, V9, P111, DOI 10.17925/EE.2013.09.02.111
   Hu T, 2018, EUR J NUTR, V57, P391, DOI 10.1007/s00394-017-1433-z
   Huang SM, 2019, FOOD FUNCT, V10, P3224, DOI [10.1039/c9fo00263d, 10.1039/C9FO00263D]
   Inayat-Hussain SH, 2010, TOXICOL LETT, V193, P108, DOI 10.1016/j.toxlet.2009.12.010
   Jandhyala SM, 2015, WORLD J GASTROENTERO, V21, P8787, DOI 10.3748/wjg.v21.i29.8787
   Javurek AB, 2017, REPROD FERT DEVELOP, V29, P1602, DOI 10.1071/RD16119
   Jayakumar P, 2014, J PHYSIOL BIOCHEM, V70, P525, DOI 10.1007/s13105-014-0332-5
   Jensen TL, 2013, LAB ANIM-UK, V47, P225, DOI 10.1177/0023677213501659
   Jomova K, 2019, MOLECULES, V24, DOI 10.3390/molecules24234335
   Kanagasabapathy G, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/185259
   Kim YJ, 2019, J MED FOOD, V22, P1151, DOI 10.1089/jmf.2018.4341
   Kowalewska B, 2016, DIS MARKERS, V2016, DOI 10.1155/2016/4685976
   Lalitha N, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0231543
   Lee DH, 2020, NUTRIENTS, V12, DOI 10.3390/nu12051459
   Lee SH, 2006, NUTR RES, V26, P474, DOI 10.1016/j.nutres.2006.06.017
   Li T, 2019, BIOMED RES INT, V2019, DOI 10.1155/2019/3746326
   Liu T, 2017, SIGNAL TRANSDUCT TAR, V2, DOI 10.1038/sigtrans.2017.23
   Liu W, 2017, MOL NUTR FOOD RES, V61, DOI 10.1002/mnfr.201601082
   Liu Y, 2020, J AGR FOOD CHEM, V68, P6368, DOI 10.1021/acs.jafc.0c02336
   Luijten IHN, 2019, MOL ASPECTS MED, V68, P42, DOI 10.1016/j.mam.2019.07.002
   Ma LY, 2020, GUT MICROBES, V12, DOI 10.1080/19490976.2020.1832857
   Malik VS, 2020, NAT REV ENDOCRINOL, V16, P615, DOI 10.1038/s41574-020-00411-y
   Matkar PN, 2017, BIOMOLECULES, V7, DOI 10.3390/biom7040074
   Nallappan D, 2023, ARCH PHYSIOL BIOCHEM, V129, P186, DOI 10.1080/13813455.2020.1808019
   Nita M, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/3164734
   Oelkrug R, 2014, FREE RADICAL BIO MED, V77, P210, DOI 10.1016/j.freeradbiomed.2014.09.004
   Ortega JT, 2017, AIDS RES THER, V14, DOI 10.1186/s12981-017-0183-6
   Pan RP, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.00185
   Parker BJ, 2020, FRONT IMMUNOL, V11, DOI 10.3389/fimmu.2020.00906
   Poret JM, 2018, INT J OBESITY, V42, P535, DOI 10.1038/ijo.2017.280
   Porras D, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.01813
   Re R, 1999, FREE RADICAL BIO MED, V26, P1231, DOI 10.1016/S0891-5849(98)00315-3
   Rehman K, 2016, J BIOMED SCI, V23, DOI 10.1186/s12929-016-0303-y
   Riedl RA, 2017, CURR HYPERTENS REP, V19, DOI 10.1007/s11906-017-0721-6
   Rinninella E, 2019, MICROORGANISMS, V7, DOI 10.3390/microorganisms7010014
   Saravanan S, 2015, EUR J PHARMACOL, V761, P279, DOI 10.1016/j.ejphar.2015.05.034
   Saulnier DM, 2011, GASTROENTEROLOGY, V141, P1782, DOI 10.1053/j.gastro.2011.06.072
   Scheja L, 2019, NAT REV ENDOCRINOL, V15, P507, DOI 10.1038/s41574-019-0230-6
   Semwal DK, 2016, NUTRIENTS, V8, DOI 10.3390/nu8020090
   Sheng Y, 2019, FOOD FUNCT, V10, P4771, DOI [10.1039/c9fo00883g, 10.1039/C9FO00883G]
   Shi J, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00703
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Stadlbauer V, 2020, BMC GERIATR, V20, DOI 10.1186/s12877-020-01644-2
   Stier A, 2014, J EXP BIOL, V217, P624, DOI 10.1242/jeb.092700
   Tan BL, 2018, FRONT PHARMACOL, V9, DOI 10.3389/fphar.2018.01162
   Tap J, 2015, ENVIRON MICROBIOL, V17, P4954, DOI 10.1111/1462-2920.13006
   Tidjani Alou M., 2016, HUM MICROBIOME J, V1, P3, DOI DOI 10.1016/J.HUMIC.2016.09.001
   Tofalo R, 2019, FRONT NUTR, V6, DOI 10.3389/fnut.2019.00016
   Tsai YW, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21249564
   Ulsenheimer BH, 2017, ACTA CIR BRAS, V32, P1, DOI 10.1590/s0102-865020170101
   Villarroya F, 2018, CELL METAB, V27, P954, DOI 10.1016/j.cmet.2018.04.006
   Wang GX, 2015, TRENDS ENDOCRIN MET, V26, P231, DOI 10.1016/j.tem.2015.03.002
   Wang JJ, 2019, FRONT MICROBIOL, V10, DOI 10.3389/fmicb.2019.00887
   White PAS, 2016, J MED FOOD, V19, P155, DOI 10.1089/jmf.2015.0034
   Xia SF, 2016, NUTRIENTS, V8, DOI 10.3390/nu8120799
   Xin SQ, 2019, INT J PHARMACOL, V15, P394, DOI 10.3923/ijp.2019.394.402
   Yokomizo A, 2005, BIOSCI BIOTECH BIOCH, V69, P693, DOI 10.1271/bbb.69.693
   Zeka Keti, 2017, Diseases, V5, DOI 10.3390/diseases5030019
   Zhang M, 2016, WORLD J GASTROENTERO, V22, P8905, DOI 10.3748/wjg.v22.i40.8905
   Zhang X, 2015, SCI REP-UK, V5, DOI 10.1038/srep14405
   Zhang XJ, 2019, NUTR METAB, V16, DOI 10.1186/s12986-019-0370-7
   Zhou LY, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00413
NR 89
TC 3
Z9 3
U1 2
U2 23
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD JUL 7
PY 2021
VL 12
IS 13
BP 5876
EP 5891
DI 10.1039/d1fo00539a
EA MAY 2021
PG 16
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA TD9OW
UT WOS:000652677200001
PM 34019055
DA 2023-06-08
ER

PT J
AU Pyra, KA
   Saha, DC
   Reimer, RA
AF Pyra, Kim A.
   Saha, Dolan C.
   Reimer, Raylene A.
TI Prebiotic Fiber Increases Hepatic Acetyl CoA Carboxylase Phosphorylation
   and Suppresses Glucose-Dependent Insulinotropic Polypeptide Secretion
   More Effectively When Used with Metformin in Obese Rats
SO JOURNAL OF NUTRITION
LA English
DT Article
ID GLUCAGON-LIKE PEPTIDE-1; ACTIVATED PROTEIN-KINASE; HIGH-FAT DIET;
   INCRETIN HORMONES; ENERGY-METABOLISM; WEIGHT-GAIN; OLIGOFRUCTOSE; GLP-1;
   EXPRESSION; SATIETY
AB Independently, rnetformin (MET) and the prebiotic, oligofructose (OFS), have been shown to increase glucagon-like peptide (GLP-1) secretion. Our objective was to determine whether using OFS as an adjunct with MET augments GLP-1 secretion in obese rats. Male, diet-induced obese Sprague Dawley rats were randomized to: 1) high-fat/-sucrose diet [HFHS; control (C); 20% fat, 50% sucrose wt:wt]; 2 HFHS+10% OFS (OFS); 2 HFHS + MET [300 mg/kg/d (MET)); 4) HFHS+10% OFS+MET (OFS +MET). Body composition, glycemia, satiety hormones, and mechanisms related to dipeptidyl peptidase 4 (DPP4) activity in plasma, hepatic AMP-activated protein kinase (AMPK; Western blots), and gut microbiota (qPCR) were examined. Direct effects of MET and SCFA were examined in human enteroendocrine cells. The interaction between OFS and MET affected fat mass, hepatic TG, secretion of glucose-dependent insulinotropic polypeptide (GIP) and leptin, and AMPK alpha 2 mRNA and phosphorylated acetyl CoA carboxylase (pACC) levels (P < 0.05). Combined, OFS and MET reduced GIP secretion to a greater extent than either treatment alone (P < 0.05). The hepatic pACC level was increased by OFS+MET by at least 50% above all other treatments, which did not differ from each other (P < 0.05). OFS decreased plasma DPP4 activity (P < 0.001). Cecal Bifidobacteria (P < 0.001) were markedly increased and C. leptum decreased (P < 0.001) with OFS consumption. In human enteroendocrine cells, the interaction between MET and SCFA affected GLP-1 secretion (P < 0.04) but was not associated with higher GLP-1 than the highest individual doses. In conclusion, the combined actions of OFS and MET were associated with important interaction effects that have the potential to improve metabolic outcomes associated with obesity. J. Nutr. 142: 213-220, 2012.
C1 [Pyra, Kim A.; Saha, Dolan C.; Reimer, Raylene A.] Univ Calgary, Fac Kinesiol, Calgary, AB, Canada.
   [Reimer, Raylene A.] Univ Calgary, Fac Med, Dept Biochem & Mol Biol, Calgary, AB, Canada.
C3 University of Calgary; University of Calgary
RP Reimer, RA (通讯作者)，Univ Calgary, Fac Kinesiol, Calgary, AB, Canada.
EM reimer@ucalgary.ca
OI Reimer, Raylene/0000-0001-5088-7947
FU Canadian Institutes of Health Research; Frederick Banting and Charles
   Best Canada Graduate Scholarship; Alberta Graduate Student Scholarship;
   Queen Elizabeth II Graduate Master's Scholarship; Faculty of
   Kinesiology; Alberta Innovates Health Solutions; Alberta Children's
   Hospital Research Institute for Maternal and Child Health CIHR
FX Supported by an unrestricted research grant from the Canadian Institutes
   of Health Research. K.A.P. was supported by the Frederick Banting and
   Charles Best Canada Graduate Scholarship, the Alberta Graduate Student
   Scholarship, the Queen Elizabeth II Graduate Master's Scholarship, and
   the Faculty of Kinesiology Graduate Research Scholarship. D.C.S. is
   supported by fellowships from Alberta Innovates Health Solutions and the
   Alberta Children's Hospital Research Institute for Maternal and Child
   Health CIHR Training Grant.
CR Alam ML, 2011, DIABETES OBES METAB, V13, P378, DOI 10.1111/j.1463-1326.2011.01358.x
   Andreelli F, 2006, ENDOCRINOLOGY, V147, P2432, DOI 10.1210/en.2005-0898
   Backhed F, 2007, P NATL ACAD SCI USA, V104, P979, DOI 10.1073/pnas.0605374104
   Blundell JE, 2008, REGUL PEPTIDES, V149, P32, DOI 10.1016/j.regpep.2007.10.009
   Cani PD, 2009, GUT, V58, P1091, DOI 10.1136/gut.2008.165886
   Cani PD, 2006, DIABETES, V55, P1484, DOI 10.2337/db05-1360
   Cani PD, 2005, OBES RES, V13, P1000, DOI 10.1038/oby.2005.117
   Delmee E, 2006, LIFE SCI, V79, P1007, DOI 10.1016/j.lfs.2006.05.013
   Delzenne NM, 2007, J NUTR, V137, p2547S, DOI 10.1093/jn/137.11.2547S
   Delzenne NM, 2003, P NUTR SOC, V62, P177, DOI 10.1079/PNS2002225
   Eller LK, 2010, J NUTR, V140, P1234, DOI 10.3945/jn.109.119008
   Gniuli D, 2010, DIABETOLOGIA, V53, P2233, DOI 10.1007/s00125-010-1830-9
   He L, 2009, CELL, V137, P635, DOI 10.1016/j.cell.2009.03.016
   Kim SJ, 2007, J BIOL CHEM, V282, P34139, DOI 10.1074/jbc.M704896200
   Kim YW, 2006, DIABETES, V55, P716, DOI 10.2337/diabetes.55.03.06.db05-0917
   Kirno Y, 2009, BIOL PHARM BULL, V32, P463, DOI 10.1248/bpb.32.463
   Ley RE, 2006, NATURE, V444, P1022, DOI 10.1038/4441022a
   Mannucci E, 2001, DIABETES CARE, V24, P489, DOI 10.2337/diacare.24.3.489
   Maurer AD, 2009, J PHYSIOL-LONDON, V587, P679, DOI 10.1113/jphysiol.2008.161844
   MAZZAFERRI EL, 1985, J CLIN ENDOCR METAB, V61, P313, DOI 10.1210/jcem-61-2-313
   Mentlein R, 2009, BEST PRACT RES CL EN, V23, P443, DOI 10.1016/j.beem.2009.03.005
   Miyawaki K, 2002, NAT MED, V8, P738, DOI 10.1038/nm727
   Musso G, 2009, AM J CLIN NUTR, V89, P558, DOI 10.3945/ajcn.2008.26720
   Papanas N, 2009, EXPERT OPIN PHARMACO, V10, P2395, DOI 10.1517/14656560903176453
   Parnell JA, BR J NUTR
   Parnell JA, 2010, BRIT J NUTR, V103, P1577, DOI 10.1017/S0007114509993539
   Parnell JA, 2009, AM J CLIN NUTR, V89, P1751, DOI 10.3945/ajcn.2009.27465
   Ranganath LR, 1996, GUT, V38, P916, DOI 10.1136/gut.38.6.916
   Rector RS, 2008, AM J PHYSIOL-GASTR L, V294, pG619, DOI 10.1152/ajpgi.00428.2007
   Reimer RA, 2001, ENDOCRINOLOGY, V142, P4522, DOI 10.1210/en.142.10.4522
   Reimer RA, 2006, J ENDOCRINOL, V191, P159, DOI 10.1677/joe.1.06557
   Roden M, 2001, RECENT PROG HORM RES, V56, P219, DOI 10.1210/rp.56.1.219
   Santacruz A, 2010, BRIT J NUTR, V104, P83, DOI 10.1017/S0007114510000176
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Verdich C, 2001, INT J OBESITY, V25, P1206, DOI 10.1038/sj.ijo.0801655
   Vilsboll T, 2001, DIABETES, V50, P609, DOI 10.2337/diabetes.50.3.609
   Viollet B, 2009, ACTA PHYSIOL, V196, P81, DOI 10.1111/j.1748-1716.2009.01970.x
   Walsh SJ, 2009, PREV MED, V49, P396, DOI 10.1016/j.ypmed.2009.09.012
   Yasuda N, 2002, BIOCHEM BIOPH RES CO, V298, P779, DOI 10.1016/S0006-291X(02)02565-2
   Zardooz H, 2010, PHYSIOL RES, V59, P973, DOI 10.33549/physiolres.931896
   Zhou GC, 2001, J CLIN INVEST, V108, P1167, DOI 10.1172/JCI200113505
   Zhou J, 2008, AM J PHYSIOL-ENDOC M, V295, pE1160, DOI 10.1152/ajpendo.90637.2008
NR 42
TC 55
Z9 70
U1 1
U2 19
PU AMER SOC NUTRITION-ASN
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-3166
EI 1541-6100
J9 J NUTR
JI J. Nutr.
PD FEB
PY 2012
VL 142
IS 2
BP 213
EP 220
DI 10.3945/jn.111.147132
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 880LN
UT WOS:000299408700002
PM 22223580
OA Bronze, Green Accepted
DA 2023-06-08
ER

PT J
AU Yan, YW
   Li, Q
   Shen, L
   Guo, KX
   Zhou, X
AF Yan, Yongwang
   Li, Qing
   Shen, Ling
   Guo, Kangxiao
   Zhou, Xu
TI Chlorogenic acid improves glucose tolerance, lipid metabolism,
   inflammation and microbiota composition in diabetic db/db mice
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE chlorogenic acid; hyperglycemia; hyperlipidemia; inflammation; oxidative
   stress
ID FATTY LIVER-DISEASE; COFFEE CONSUMPTION; OXIDATIVE STRESS; GUT
   MICROBIOTA; RISK; OBESITY; DIET
AB IntroductionChronic and acute chlorogenic acid (CGA) can improve glucose tolerance (GT) and insulin sensitivity (IS). However, whether acute administration of CGA has beneficial effects on hepatic lipid metabolism and cecal microbiota composition remains unclear. MethodsIn the current study, diabetic db/db mice were administered CGA or metformin, and db/m mice were used as controls to explore the effects of CGA on hepatic lipid metabolism, including fatty acid oxidation and transportation and triglyceride (TG) lipolysis and synthesis. Moreover, alterations in the inflammatory response and oxidative stress in the liver and gut microbe composition were evaluated. ResultsThe results showed that CGA decreased body weight and improved glucose tolerance and insulin resistance, and these effects were similar to those of metformin. CGA decreased hepatic lipid content by increasing the expression of CPT1a (carnitine palmitoyltransferase 1a), ACOX1 (Acyl-CoA oxidase 1), ATGL (adipose triglyceride lipase), and HSL (hormone-sensitive lipase) and decreasing that of MGAT1 (monoacylglycerol O-acyltransferase 1), DGAT1 (diacylglycerol O-acyltransferase), DGAT2, CD36, and FATP4 (fatty acid transport protein 4). Additionally, CGA restored the expression of inflammatory genes, including TNF-alpha (tumor necrosis factor-alpha), IL-1 beta (interleukin-1beta), IL-6, and IL-10, and genes encoding antioxidant enzymes, including SOD1 (superoxide dismutases 1), SOD2 (superoxide dismutases 2), and GPX1 (glutathione peroxidase 1). Furthermore, CGA improved the bacterial alpha and beta diversity in the cecum. Moreover, CGA recovered the abundance of the phylum Bacteroidetes and the genera Lactobacillus, Blautia, and Enterococcus. DiscussionCGA can improve the antidiabetic effects, and microbes may critically mediate these beneficial effects.
C1 [Yan, Yongwang; Shen, Ling; Guo, Kangxiao] Changsha Hlth Vocat Coll, Pharmaceut Coll, Changsha, Peoples R China.
   [Li, Qing] Changsha Hlth Vocat Coll, Dept Pathol, Changsha, Peoples R China.
   [Guo, Kangxiao] Cent South Univ Forestry & Technol, Coll Food Sci & Engn, Natl Engn Lab Rice & By Prod Deep Proc, Changsha, Peoples R China.
   [Zhou, Xu] Hunan Acad Tradit Chinese Med, Affiliated Hosp, Dept Spleen Stomach & Liver Dis, Changsha, Peoples R China.
C3 Central South University of Forestry & Technology
RP Zhou, X (通讯作者)，Hunan Acad Tradit Chinese Med, Affiliated Hosp, Dept Spleen Stomach & Liver Dis, Changsha, Peoples R China.
FU Changsha Municipal Natural Science Foundation; Natural Science
   Foundation of Hunan Province;  [kq2014029];  [2022JJ60111]
FX Funding This work was supported by the Changsha Municipal Natural
   Science Foundation (grant number kq2014029) and Natural Science
   Foundation of Hunan Province (2022JJ60111).
CR Asrih M, 2013, J ENDOCRINOL, V218, pR25, DOI 10.1530/JOE-13-0201
   Bambha K, 2014, LIVER INT, V34, P1250, DOI 10.1111/liv.12379
   Bhandarkar NS, 2019, NUTR RES, V62, P78, DOI 10.1016/j.nutres.2018.11.002
   Budryn G, 2017, PLANT FOOD HUM NUTR, V72, P184, DOI 10.1007/s11130-017-0608-3
   Cejas JP, 2021, BBA-BIOMEMBRANES, V1863, DOI 10.1016/j.bbamem.2020.183484
   Chen F, 2021, ANIM SCI J, V92, DOI 10.1111/asj.13619
   Chen L, 2020, FOOD CHEM TOXICOL, V136, DOI 10.1016/j.fct.2019.111072
   Chen L, 2019, FOOD CHEM TOXICOL, V127, P182, DOI 10.1016/j.fct.2019.03.038
   de Sotillo DVR, 2002, J NUTR BIOCHEM, V13, P717, DOI 10.1016/S0955-2863(02)00231-0
   Demidova TY, 2020, TERAPEVT ARKH, V92, P97, DOI 10.26442/00403660.2020.10.000778
   Goldstein EJC, 2015, CLIN INFECT DIS, V60, pS98, DOI 10.1093/cid/civ072
   Gonthier MP, 2003, J NUTR, V133, P1853, DOI 10.1093/jn/133.6.1853
   He LQ, 2022, MOL THER, V30, P388, DOI 10.1016/j.ymthe.2021.08.025
   He XY, 2021, J SCI FOOD AGR, V101, P631, DOI 10.1002/jsfa.10675
   Hermawati E, 2020, EUR J NEUROSCI, V51, P651, DOI 10.1111/ejn.14556
   Jiao AR, 2020, FOOD FUNCT, V11, P1845, DOI [10.1039/C9FO02585E, 10.1039/c9fo02585e]
   Le YJ, 2022, FEMS MICROBIOL LETT, V369, DOI 10.1093/femsle/fnac061
   Li XY, 2021, 3 BIOTECH, V11, DOI 10.1007/s13205-020-02558-x
   Liu XM, 2021, GUT MICROBES, V13, DOI 10.1080/19490976.2021.1875796
   Long CX, 2021, ANIM BIOTECHNOL, DOI 10.1080/10495398.2021.2010089
   Miao MS, 2020, ADV PHARMACOL, V87, P71, DOI 10.1016/bs.apha.2019.12.002
   Ong KW, 2013, BIOCHEM PHARMACOL, V85, P1341, DOI 10.1016/j.bcp.2013.02.008
   Parkar SG, 2013, ANAEROBE, V23, P12, DOI 10.1016/j.anaerobe.2013.07.009
   Pimpley V, 2020, PREP BIOCHEM BIOTECH, V50, P969, DOI 10.1080/10826068.2020.1786699
   Raman M, 2013, CLIN GASTROENTEROL H, V11, P868, DOI 10.1016/j.cgh.2013.02.015
   Rondanelli M, 2020, NUTRIENTS, V12, DOI 10.3390/nu12113298
   Santana-Galvez J, 2017, MOLECULES, V22, DOI 10.3390/molecules22030358
   Sewter R, 2021, NUTRIENTS, V13, DOI 10.3390/nu13072381
   Shao HQ, 2020, BMC MICROBIOL, V20, DOI 10.1186/s12866-020-01999-x
   Shi AM, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.693048
   Song J, 2019, FOOD FUNCT, V10, P2947, DOI [10.1039/c8fo02599a, 10.1039/C8FO02599A]
   Tajik N, 2017, EUR J NUTR, V56, P2215, DOI 10.1007/s00394-017-1379-1
   Wang ZY, 2019, FOOD SCI NUTR, V7, P579, DOI 10.1002/fsn3.868
   Wijarnpreecha K, 2017, EUR J GASTROEN HEPAT, V29, pE8, DOI 10.1097/MEG.0000000000000776
   Wohlgemuth S, 2011, GUT MICROBES, V2, P159, DOI 10.4161/gmic.2.3.16104
   Wu Y, 2018, INT J FOOD SCI NUTR, V69, P566, DOI 10.1080/09637486.2017.1394449
   Xu M, 2019, FOOD FUNCT, V10, P7489, DOI 10.1039/c9fo00502a
   Xu WP, 2022, COMPUT MATH METHOD M, V2022, DOI 10.1155/2022/6282167
   Yan YW, 2020, FRONT IMMUNOL, V11, DOI 10.3389/fimmu.2020.01125
   Yan YW, 2020, J IMMUNOL RES, V2020, DOI 10.1155/2020/9680508
   Ye XL, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.762691
   Yu F, 2019, AGING-US, V11, P10454, DOI 10.18632/aging.102469
   Zamani-Garmsiri F, 2021, IUBMB LIFE, V73, P252, DOI 10.1002/iub.2424
   Zhang CY, 2020, BMC MICROBIOL, V20, DOI 10.1186/s12866-020-01864-x
   Zhang XY, 2020, GUT MICROBES, V12, DOI 10.1080/19490976.2020.1842990
   Zhang XH, 2020, POULTRY SCI, V99, P6606, DOI 10.1016/j.psj.2020.09.082
   Zhou XH, 2022, GUT MICROBES, V14, DOI 10.1080/19490976.2022.2091369
   Zhou XH, 2021, ANIM NUTR, V7, P384, DOI 10.1016/j.aninu.2020.08.011
   Zhou XH, 2017, MOL NUTR FOOD RES, V61, DOI 10.1002/mnfr.201700262
   Zuniga LY, 2018, J MED FOOD, V21, P469, DOI 10.1089/jmf.2017.0110
NR 50
TC 1
Z9 1
U1 14
U2 14
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD NOV 17
PY 2022
VL 13
AR 1042044
DI 10.3389/fendo.2022.1042044
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 6S0QZ
UT WOS:000892703300001
PM 36465648
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Huang, ZR
   Zhao, LY
   Zhu, FR
   Liu, Y
   Xiao, JY
   Chen, ZC
   Lv, XC
   Huang, Y
   Liu, B
AF Huang, Zi-Rui
   Zhao, Li-Yuan
   Zhu, Fu-Rong
   Liu, Yun
   Xiao, Jian-Yong
   Chen, Zhi-Chao
   Lv, Xu-Cong
   Huang, Ying
   Liu, Bin
TI Anti-Diabetic Effects of Ethanol Extract from Sanghuangporous vaninii in
   High-Fat/Sucrose Diet and Streptozotocin-Induced Diabetic Mice by
   Modulating Gut Microbiota
SO FOODS
LA English
DT Article
DE Sanghuangporous vaninii; anti-diabetic effect; hyperglycemia;
   hyperlipidemia; gut microbiota
ID METFORMIN TREATMENT; INSULIN-RESISTANCE; CARBOHYDRATE-METABOLISM;
   PHELLINUS-LINTEUS; GLUCOSE; POLYSACCHARIDE; OBESITY; ASSOCIATION;
   HYPERLIPIDEMIA; INFLAMMATION
AB Type 2 diabetes mellitus (T2DM) may lead to abnormally elevated blood glucose, lipid metabolism disorder, and low-grade inflammation. Besides, the development of T2DM is always accompanied by gut microbiota dysbiosis and metabolic dysfunction. In this study, the T2DM mice model was established by feeding a high-fat/sucrose diet combined with injecting a low dose of streptozotocin. Additionally, the effects of oral administration of ethanol extract from Sanghuangporous vaninii (SVE) on T2DM and its complications (including hypoglycemia, hyperlipidemia, inflammation, and gut microbiota dysbiosis) were investigated. The results showed SVE could improve body weight, glycolipid metabolism, and inflammation-related parameters. Besides, SVE intervention effectively ameliorated the diabetes-induced pancreas and jejunum injury. Furthermore, SVE intervention significantly increased the relative abundances of Akkermansia, Dubosiella, Bacteroides, and Parabacteroides, and decreased the levels of Lactobacillus, Flavonifractor, Odoribacter, and Desulfovibrio compared to the model group (LDA > 3.0, p < 0.05). Metabolic function prediction of the intestinal microbiota by PICRUSt revealed that glycerolipid metabolism, insulin signaling pathway, PI3K-Akt signaling pathway, and fatty acid degradation were enriched in the diabetic mice treated with SVE. Moreover, the integrative analysis indicated that the key intestinal microbial phylotypes in response to SVE intervention were strongly correlated with glucose and lipid metabolism-associated biochemical parameters. These findings demonstrated that SVE has the potential to alleviate T2DM and its complications by modulating the gut microbiota imbalance.
C1 [Huang, Zi-Rui; Zhao, Li-Yuan; Liu, Yun; Xiao, Jian-Yong; Chen, Zhi-Chao; Huang, Ying] Fujian Agr & Forestry Univ, Coll Food Sci, Fuzhou 350002, Peoples R China.
   [Huang, Zi-Rui; Zhu, Fu-Rong; Liu, Bin] Natl Engn Res Ctr JUNCAO Technol, Fuzhou 350002, Peoples R China.
   [Lv, Xu-Cong] Fuzhou Univ, Inst Food Sci & Technol, Coll Biol Sci & Technol, Fuzhou 350108, Peoples R China.
C3 Fujian Agriculture & Forestry University; Chinese Academy of
   Agricultural Sciences; Institute of Food Science & Technology, CAAS;
   Fuzhou University
RP Huang, Y (通讯作者)，Fujian Agr & Forestry Univ, Coll Food Sci, Fuzhou 350002, Peoples R China.; Liu, B (通讯作者)，Natl Engn Res Ctr JUNCAO Technol, Fuzhou 350002, Peoples R China.; Lv, XC (通讯作者)，Fuzhou Univ, Inst Food Sci & Technol, Coll Biol Sci & Technol, Fuzhou 350108, Peoples R China.
EM inaccelworld@gmail.com; lsfood89@163.com; lyrazfr@163.com;
   liuyun12086@163.com; fjxjy19@sina.com; czc202202@163.com;
   liubin618@hotmail.com; yinghuangyh@126.com; liubin618@hotmail.com
RI LI, XIAO/IQV-9318-2023
OI Huang, Zirui/0000-0002-0822-352X; Lv, Xu-Cong/0000-0002-0594-4284
FU Fujian Province Science and Technology Major Special Projects
   [2021NZ0101, 2014NZ2002-1]; Interdisciplinary Integration to promote the
   high-quality development projects of Juncao Science and Industry
   [XKJC-712021030]
FX Analysis of gut microbiome data was assisted by Biotree Biotech Co.,
   Ltd. (Shanghai, China).; This research was funded by the Fujian Province
   Science and Technology Major Special Projects (2021NZ0101),
   Interdisciplinary Integration to promote the high-quality development
   projects of Juncao Science and Industry (XKJC-712021030), and Fujian
   Province Science and Technology Major Special Projects (2014NZ2002-1).
CR Abdelhafez OH, 2020, PHYTOCHEM ANALYSIS, V31, P204, DOI 10.1002/pca.2883
   Adeoye-Isijola M. O., 2018, African Journal of Traditional, Complementary and Alternative Medicines, V15, P42, DOI 10.21010/ajtcamv15i2.6
   Ai XJ, 2021, FRONT MICROBIOL, V12, DOI 10.3389/fmicb.2021.682290
   Angelini G, 2021, GUT, V70, P1098, DOI 10.1136/gutjnl-2020-322073
   Anhe FF, 2020, NAT METAB, V2, P233, DOI 10.1038/s42255-020-0178-9
   Anisimov VN, 2011, AGING-US, V3, P148, DOI 10.18632/aging.100273
   Behari J, 2010, AM J PATHOL, V176, P744, DOI 10.2353/ajpath.2010.090667
   Blandino G, 2016, DIABETES METAB, V42, P303, DOI 10.1016/j.diabet.2016.04.004
   Blaut M, 2015, P NUTR SOC, V74, P227, DOI 10.1017/S0029665114001700
   Canfora EE, 2019, NAT REV ENDOCRINOL, V15, P261, DOI 10.1038/s41574-019-0156-z
   Cani PD, 2014, M S-MED SCI, V30, P125, DOI 10.1051/medsci/20143002003
   Chen M, 2020, FOOD FUNCT, V11, P3316, DOI 10.1039/c9fo03003d
   Cheng Y, 2019, INT J BIOL MACROMOL, V131, P1162, DOI 10.1016/j.ijbiomac.2019.04.040
   Choi BG, 2019, YONSEI MED J, V60, P191
   Ding KX, 2020, NUTRIENTS, V12, DOI 10.3390/nu12061712
   Dong YH, 2019, FOOD FUNCT, V10, P3880, DOI [10.1039/c9fo00583h, 10.1039/C9FO00583H]
   Douglas GM, 2020, NAT BIOTECHNOL, V38, P685, DOI 10.1038/s41587-020-0548-6
   DUNN FL, 1982, MED CLIN N AM, V66, P1347, DOI 10.1016/S0025-7125(16)31368-2
   Feng YL, 2019, CELL MOL LIFE SCI, V76, P4961, DOI 10.1007/s00018-019-03155-9
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Frier BC, 2008, CELL STRESS CHAPERON, V13, P287, DOI 10.1007/s12192-008-0062-0
   Grgurevic L, 2016, CYTOKINE GROWTH F R, V27, P105, DOI 10.1016/j.cytogfr.2015.12.009
   Gulnaz A, 2021, BIOLOGY-BASEL, V10, DOI 10.3390/biology10040348
   Guo WL, 2020, INT J BIOL MACROMOL, V145, P1208, DOI 10.1016/j.ijbiomac.2019.09.206
   Guo WL, 2018, FOOD FUNCT, V9, P3419, DOI 10.1039/c8fo00836a
   Guo X, 2021, FOOD FUNCT, V12, P9300, DOI [10.1039/d0fo03423a, 10.1039/D0FO03423A]
   Gurung M, 2020, EBIOMEDICINE, V51, DOI 10.1016/j.ebiom.2019.11.051
   Han S, 2022, FOOD BIOSCI, V45, DOI 10.1016/j.fbio.2021.101500
   Huang GJ, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0035922
   Huang ZR, 2020, J AGR FOOD CHEM, V68, P6530, DOI 10.1021/acs.jafc.9b08211
   Irudayaraj SS, 2017, PHARM BIOL, V55, P1074, DOI 10.1080/13880209.2017.1279671
   Jeong HJ, 2008, FOOD SCI BIOTECHNOL, V17, P274
   Jia RB, 2020, INT J BIOL MACROMOL, V164, P2659, DOI 10.1016/j.ijbiomac.2020.08.154
   Jia RB, 2020, INT J BIOL MACROMOL, V147, P428, DOI 10.1016/j.ijbiomac.2019.12.243
   Jiang X, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-05560-1
   Karlsson FH, 2012, NAT COMMUN, V3, DOI 10.1038/ncomms2266
   Kashyap Sangeeta R, 2007, Diab Vasc Dis Res, V4, P13, DOI 10.3132/dvdr.2007.001
   Li D, 2020, FOOD BIOSCI, V36, DOI 10.1016/j.fbio.2020.100637
   Li HZ, 2021, J AGR FOOD CHEM, V69, P183, DOI 10.1021/acs.jafc.0c06346
   Li MY, 2022, FOOD FUNCT, V13, P688, DOI [10.1039/d1fo03677g, 10.1039/D1FO03677G]
   Li TT, 2021, FOOD RES INT, V147, DOI 10.1016/j.foodres.2021.110530
   Li X, 2019, FOOD FUNCT, V10, P775, DOI 10.1039/c8fo02271b
   Li Xing, 2021, Zhongguo Zhong Yao Za Zhi, V46, P177, DOI 10.19540/j.cnki.cjcmm.20200915.403
   Li Y, 2019, J FUNCT FOODS, V53, P54, DOI 10.1016/j.jff.2018.12.015
   Li ZR, 2021, INT J BIOL MACROMOL, V170, P447, DOI 10.1016/j.ijbiomac.2020.12.126
   Liao CX, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0140595
   Lin GP, 2021, PHARMACOL RES, V165, DOI 10.1016/j.phrs.2021.105436
   Lin WC, 2017, RSC ADV, V7, P7780, DOI 10.1039/c6ra27198g
   Lippert K, 2017, BENEF MICROBES, V8, P545, DOI 10.3920/BM2016.0184
   Liu J, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-10487-4
   Liu TH, 2021, FRONT NUTR, V8, DOI 10.3389/fnut.2021.639467
   Liu YY, 2020, FASEB J, V34, P1065, DOI 10.1096/fj.201901943RR
   Liu YY, 2019, NUTRIENTS, V11, DOI 10.3390/nu11020296
   Lontchi-Yimagou E, 2013, CURR DIABETES REP, V13, P435, DOI 10.1007/s11892-013-0375-y
   Loy SL, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-00445-w
   Lye HS, 2017, J BIOTECHNOL, V262, P75, DOI 10.1016/j.jbiotec.2017.09.007
   Ma XK, 2019, J MICROBIOL, V57, P812, DOI 10.1007/s12275-019-9036-4
   Meng X, 2019, J BIOL ENG, V13, DOI 10.1186/s13036-019-0163-6
   Morita Y, 2020, DIABETES CARE, V43, P1796, DOI 10.2337/dc20-0093
   Murphy EF, 2010, GUT, V59, P1635, DOI 10.1136/gut.2010.215665
   Pahwa R, 2017, J DIABETES RES, V2017, DOI 10.1155/2017/6519785
   Pan YY, 2018, FOOD FUNCT, V9, P6269, DOI 10.1039/c8fo01116h
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Scheithauer TPM, 2020, FRONT IMMUNOL, V11, DOI 10.3389/fimmu.2020.571731
   Song HZ, 2016, J GASTROEN HEPATOL, V31, P1462, DOI 10.1111/jgh.13278
   Sun YN, 2020, TRENDS FOOD SCI TECH, V105, P468, DOI 10.1016/j.tifs.2019.02.026
   Swaroop JJ, 2012, INDIAN J MED RES, V135, P127, DOI 10.4103/0971-5916.93435
   Tong XL, 2018, MBIO, V9, DOI 10.1128/mBio.02392-17
   Tremaroli V, 2012, NATURE, V489, P242, DOI 10.1038/nature11552
   Wang D, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19010137
   Wang H, 2020, MOL NUTR FOOD RES, V64, DOI 10.1002/mnfr.201900876
   Wang P, 2020, FREE RADICAL BIO MED, V156, P83, DOI 10.1016/j.freeradbiomed.2020.04.013
   Wang WH, 2015, EVID-BASED COMPL ALT, V2015, DOI 10.1155/2015/783460
   Wang YT, 2020, APPL MICROBIOL BIOT, V104, P3541, DOI 10.1007/s00253-020-10449-7
   Wang YX, 2020, DIABETES METAB SYNDR, V13, P835, DOI 10.2147/DMSO.S240728
   Wang ZN, 2011, NATURE, V472, P57, DOI 10.1038/nature09922
   Wei XY, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-22094-2
   WETHERED JM, 1985, NEW PHYTOL, V101, P631, DOI 10.1111/j.1469-8137.1985.tb02869.x
   [吴声华 Wu Shenghua], 2020, [菌物学报, Mygosystema], V39, P781
   Wu SY, 2021, FOOD RES INT, V147, DOI 10.1016/j.foodres.2021.110550
   Xu JL, 2018, FOOD FUNCT, V9, P3330, DOI 10.1039/c8fo00095f
   Yang JP, 2015, FRONT PHYSIOL, V6, DOI 10.3389/fphys.2015.00216
   Yang M, 2012, AM J PATHOL, V180, P2375, DOI 10.1016/j.ajpath.2012.03.010
   Yang YX, 2020, AM J PHYSIOL-GASTR L, V319, pG549, DOI 10.1152/ajpgi.00152.2020
   Yoo JH, 2020, NUTR RES, V75, P15, DOI 10.1016/j.nutres.2019.12.005
   Zhao C, 2014, J FOOD SCI, V79, pH1002, DOI 10.1111/1750-3841.12464
NR 86
TC 8
Z9 8
U1 19
U2 40
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2304-8158
J9 FOODS
JI Foods
PD APR
PY 2022
VL 11
IS 7
AR 974
DI 10.3390/foods11070974
PG 17
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 0M2QS
UT WOS:000782005800001
PM 35407061
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Letchumanan, G
   Abdullah, N
   Marlini, M
   Baharom, N
   Lawley, B
   Omar, MR
   Mohideen, FBS
   Addnan, FH
   Fariha, MMN
   Ismail, Z
   Pathmanathan, SG
AF Letchumanan, Geetha
   Abdullah, Natasya
   Marlini, Muhamad
   Baharom, Nizam
   Lawley, Blair
   Omar, Mohd Rahman
   Mohideen, Fathima Begum Syed
   Addnan, Faizul Helmi
   Nur Fariha, Mohd Manzor
   Ismail, Zarini
   Pathmanathan, Siva Gowri
TI Gut Microbiota Composition in Prediabetes and Newly Diagnosed Type 2
   Diabetes: A Systematic Review of Observational Studies
SO FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
LA English
DT Review
DE gut microbiota; type 2 diabetes; prediabetes; 16S rRNA sequencing;
   systematic review
ID INTESTINAL MICROBIOTA; CLASSIFICATION; METAGENOME; METFORMIN; BACTERIA;
   MELLITUS; OBESITY; DIET
AB Evidence of gut microbiota involvement in regulating glucose metabolism and type 2 diabetes mellitus (T2DM) progression is accumulating. The understanding of microbial dysbiosis and specific alterations of gut microbiota composition that occur during the early stages of glucose intolerance, unperturbed by anti-diabetic medications, is especially essential. Hence, this systematic review was conducted to summarise the existing evidence related to microbiota composition and diversity in individuals with prediabetes (preDM) and individuals newly diagnosed with T2DM (newDM) in comparison to individuals with normal glucose tolerance (nonDM). A systematic search of the PubMed, MEDLINE and CINAHL databases were conducted from inception to February 2021 supplemented with manual searches of the list of references. The primary keywords of "type 2 diabetes", "prediabetes", "newly-diagnosed" and "gut microbiota" were used. Observational studies that conducted analysis of the gut microbiota of respondents with preDM and newDM were included. The quality of the studies was assessed using the modified Newcastle-Ottawa scale by independent reviewers. A total of 18 studies (5,489 participants) were included. Low gut microbial diversity was generally observed in preDM and newDM when compared to nonDM. Differences in gut microbiota composition between the disease groups and nonDM were inconsistent across the included studies. Four out of the 18 studies found increased abundance of phylum Firmicutes along with decreased abundance of Bacteroidetes in newDM. At the genus/species levels, decreased abundance of Faecalibacterium prausnitzii, Roseburia, Dialister, Flavonifractor, Alistipes, Haemophilus and Akkermansia muciniphila and increased abundance of Lactobacillus, Streptococcus, Escherichia, Veillonella and Collinsella were observed in the disease groups in at least two studies. Lactobacillus was also found to positively correlate with fasting plasma glucose (FPG), HbA1c and/or homeostatic assessment of insulin resistance (HOMA-IR) in four studies. This renders a need for further investigations on the species/strain-specific role of endogenously present Lactobacillus in glucose regulation mechanism and T2DM disease progression. Differences in dietary intake caused significant variation in specific bacterial abundances. More studies are needed to establish more consistent associations, between clinical biomarkers or dietary intake and specific gut bacterial composition in prediabetes and early T2DM.
C1 [Letchumanan, Geetha; Abdullah, Natasya; Marlini, Muhamad; Addnan, Faizul Helmi; Nur Fariha, Mohd Manzor; Ismail, Zarini; Pathmanathan, Siva Gowri] Univ Sains Islam Malaysia USIM, Fac Med & Hlth Sci, Dept Med Sci, Negeri Sembilan, Malaysia.
   [Baharom, Nizam] Univ Sains Islam Malaysia USIM, Fac Med & Hlth Sci, Dept Primary Hlth Care, Publ Hlth Unit, Negeri Sembilan, Malaysia.
   [Lawley, Blair] Univ Otago, Sch Biomed Sci, Dept Microbiol & Immunol, Dunedin, New Zealand.
   [Omar, Mohd Rahman] Univ Sains Islam Malaysia USIM, Fac Med & Hlth Sci, Med based Dept, Negeri Sembilan, Malaysia.
   [Mohideen, Fathima Begum Syed] Univ Sains Islam Malaysia USIM, Fac Med & Hlth Sci, Dept Primary Hlth Care, Family Med Unit, Negeri Sembilan, Malaysia.
C3 Universiti Sains Islam Malaysia; Universiti Sains Islam Malaysia;
   University of Otago; Universiti Sains Islam Malaysia; Universiti Sains
   Islam Malaysia
RP Pathmanathan, SG (通讯作者)，Univ Sains Islam Malaysia USIM, Fac Med & Hlth Sci, Dept Med Sci, Negeri Sembilan, Malaysia.
CR Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   Allin KH, 2018, DIABETOLOGIA, V61, P810, DOI 10.1007/s00125-018-4550-1
   Almugadam BS, 2020, J DIABETES RES, V2020, DOI 10.1155/2020/7253978
   Anhe FF, 2021, CELL REP, V36, DOI 10.1016/j.celrep.2021.109691
   Bhute SS, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.00214
   Bjerre RD, 2017, BRIT J DERMATOL, V177, P1272, DOI 10.1111/bjd.15390
   Bressa C, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0171352
   Candela M, 2016, BRIT J NUTR, V116, P80, DOI 10.1017/S0007114516001045
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   Centers for Disease Control and Prevention, 2020, NAT DIAB STAT REP 20
   Chavez-Carbajal A, 2020, MICROORGANISMS, V8, DOI 10.3390/microorganisms8010094
   Chen J, 2016, SCI REP-UK, V6, DOI 10.1038/srep28484
   Chen PC, 2019, NUTRITION, V63-64, P51, DOI 10.1016/j.nut.2018.11.019
   d'Hennezel E, 2017, MSYSTEMS, V2, DOI 10.1128/mSystems.00046-17
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Diener C, 2021, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.602326
   Eades CE, 2014, DIABETES RES CLIN PR, V104, pE16, DOI 10.1016/j.diabres.2014.01.012
   Egshatyan L, 2016, ENDOCR CONNECT, V5, P1, DOI 10.1530/EC-15-0094
   Ericson U, 2020, J NUTR, V150, P861, DOI 10.1093/jn/nxz293
   Falony G, 2016, SCIENCE, V352, P560, DOI 10.1126/science.aad3503
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Gaike AH, 2020, MSYSTEMS, V5, DOI 10.1128/mSystems.00578-19
   Ghaemi F, 2020, J DIABETES METAB DIS, V19, P1199, DOI 10.1007/s40200-020-00625-x
   Graessler J, 2013, PHARMACOGENOMICS J, V13, P514, DOI 10.1038/tpj.2012.43
   Gurung M, 2020, EBIOMEDICINE, V51, DOI 10.1016/j.ebiom.2019.11.051
   Han JL, 2014, WORLD J GASTROENTERO, V20, P17737, DOI 10.3748/wjg.v20.i47.17737
   International Diabetes Federation (IDF), 2019, CLIN PRACT REC MAN T, V9th edn
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Lambeth Stacey M, 2015, J Diabetes Obes, V2, P1
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Le KA, 2013, FRONT PHYSIOL, V3, DOI 10.3389/fphys.2012.00496
   Lee E, 2018, NUTRIENTS, V10, DOI 10.3390/nu10050643
   Levy M, 2016, GENE DEV, V30, P1589, DOI 10.1101/gad.284091.116
   Li LS, 2020, ANN TRANSL MED, V8, DOI 10.21037/atm-20-6717
   Lin H, 2020, NPJ BIOFILMS MICROBI, V6, DOI 10.1038/s41522-020-00160-w
   Liu WX, 2020, BIOMED RES INT, V2020, DOI 10.1155/2020/7828392
   Louca S, 2018, NAT ECOL EVOL, V2, P936, DOI 10.1038/s41559-018-0519-1
   Magne F, 2020, NUTRIENTS, V12, DOI 10.3390/nu12051474
   Martin R, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.00346
   Megrian D, 2020, MOL MICROBIOL, V113, P659, DOI 10.1111/mmi.14469
   Moher D, 2009, J CLIN EPIDEMIOL, V62, P1006, DOI 10.1016/j.jclinepi.2009.06.005
   Mukherjee A, 2020, GUT MICROBES, V12, DOI 10.1080/19490976.2020.1802866
   Norskov-Lauritsen N, 2014, CLIN MICROBIOL REV, V27, P214, DOI 10.1128/CMR.00103-13
   Nuli R, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00295
   Venegas DP, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.00277
   Park KY, 2015, J CLIN BIOCHEM NUTR, V56, P240, DOI 10.3164/jcbn.14-116
   Parker BJ, 2020, FRONT IMMUNOL, V11, DOI 10.3389/fimmu.2020.00906
   Pathmanathan S.G., 2020, SYSTEMATIC REV
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Remely M, 2014, GENE, V537, P85, DOI 10.1016/j.gene.2013.11.081
   Rinninella E, 2019, MICROORGANISMS, V7, DOI 10.3390/microorganisms7010014
   Roager HM, 2016, NAT MICROBIOL, V1, DOI [10.1038/NMICROBIOL.2016.93, 10.1038/nmicrobiol.2016.93]
   Saeedi P, 2019, DIABETES RES CLIN PR, V157, DOI 10.1016/j.diabres.2019.107843
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Silva YP, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.00025
   Stojanov S, 2020, MICROORGANISMS, V8, DOI 10.3390/microorganisms8111715
   Tamanai-Shacoori Z, 2017, FUTURE MICROBIOL, V12, P157, DOI 10.2217/fmb-2016-0130
   van Soest APM, 2020, NUTRIENTS, V12, DOI 10.3390/nu12113471
   Wang L, 2021, FRONT CELL INFECT MI, V11, DOI 10.3389/fcimb.2021.598672
   Wells G., 2014, NEWCASTLE OTTAWA SCA
   Wiwanitkit Viroj, 2011, Indian J Endocrinol Metab, V15, pS70, DOI 10.4103/2230-8210.83050
   Worldometer, 2021, WORLD POP
   Wu H, 2020, CELL METAB, V32, P379, DOI 10.1016/j.cmet.2020.06.011
   Wu XK, 2010, CURR MICROBIOL, V61, P69, DOI 10.1007/s00284-010-9582-9
   Yun SI, 2009, J APPL MICROBIOL, V107, P1681, DOI 10.1111/j.1365-2672.2009.04350.x
   Zeuthen LH, 2006, CLIN VACCINE IMMUNOL, V13, P365, DOI 10.1128/CVI.13.3.365-375.2006
   Zhang XY, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0071108
   Zhao LJ, 2019, ENDOCRINE, V66, P526, DOI 10.1007/s12020-019-02103-8
   Zhong HZ, 2019, EBIOMEDICINE, V47, P373, DOI 10.1016/j.ebiom.2019.08.048
NR 70
TC 5
Z9 5
U1 4
U2 10
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2235-2988
J9 FRONT CELL INFECT MI
JI Front. Cell. Infect. Microbiol.
PD AUG 15
PY 2022
VL 12
AR 943427
DI 10.3389/fcimb.2022.943427
PG 15
WC Immunology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Microbiology
GA 4E5MN
UT WOS:000847869400001
PM 36046745
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Ma, YY
   Li, L
   Yu, CH
   Shen, Z
   Chen, LH
   Li, YM
AF Ma, Yan-Yan
   Li, Lin
   Yu, Chao-Hui
   Shen, Zhe
   Chen, Li-Hua
   Li, You-Ming
TI Effects of probiotics on nonalcoholic fatty liver disease: A
   meta-analysis
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Article
DE Probiotics; Nonalcoholic fatty liver disease; Nonalcoholic
   steatohepatitis; Liver function; Insulin resistance; Meta-analysis
ID INCREASED INTESTINAL PERMEABILITY; NECROSIS-FACTOR-ALPHA;
   LACTOBACILLUS-ACIDOPHILUS; OBESITY; STEATOHEPATITIS; BIFIDOBACTERIA;
   PATHOGENESIS; MICROFLORA; MICROBIOTA; METFORMIN
AB AIM: To investigate the relationship between the gutliver axis and nonalcoholic fatty liver disease (NAFLD), we performed a meta-analysis to evaluate the effects of probiotic therapy in NAFLD.
   METHODS: We searched PubMed, Medline, Embase, Web of Science, the Cochrane Library and Chinese Biomedicine Database for all relevant randomized controlled trials on probiotics in patients with NAFLD/non-alcoholic steatohepatitis (NASH). A statistical analysis was performed using RevMan 5.0 software.
   RESULTS: Four randomized trials involving 134 NAFLD/NASH patients were included. The results showed that probiotic therapy significantly decreased alanine aminotransferase (ALT), aspartate transaminase (AST), total-cholesterol (T-chol), high density lipoprotein (HDL), tumor necrosis factor (TNF)-alpha and homeostasis model assessment of insulin resistance (HOMAIR) [ALT: weighted mean difference (WMD) -23.71, 95%CI: -33.46-13.95, P < 0.00001; AST: WMD -19.77, 95%CI: -32.55-7.00, P = 0.002; T-chol: WMD -0.28, 95%CI: -0.55-0.01, P = 0.04; HDL: WMD -0.09, 95%CI: -0.16-0.01, P = 0.03; TNF-alpha: WMD -0.32, 95%CI: -0.48-0.17, P < 0.0001; HOMA-IR: WMD -0.46, 95%CI: -0.73-0.19, P = 0.0008]. However, the use of probiotics was not associated with changes in body mass index (BMI), glucose (GLU) and low density lipoprotein (LDL) (BMI: WMD 0.05, 95%CI: -0.18-0.29, P = 0.64; GLU: WMD 0.05, 95%CI: -0.25-0.35, P = 0.76; LDL: WMD -0.38, 95%CI: -0.78-0.02, P = 0.06).
   CONCLUSION: Probiotic therapies can reduce liver aminotransferases, total-cholesterol, TNF-a and improve insulin resistance in NAFLD patients. Modulation of the gut microbiota represents a new treatment for NAFLD. (C) 2013 Baishideng. All rights reserved.
C1 [Ma, Yan-Yan; Li, Lin; Yu, Chao-Hui; Shen, Zhe; Chen, Li-Hua; Li, You-Ming] Zhejiang Univ, Affiliated Hosp 1, Dept Gastroenterol, Sch Med, Hangzhou 310003, Zhejiang, Peoples R China.
C3 Zhejiang University
RP Li, YM (通讯作者)，Zhejiang Univ, Affiliated Hosp 1, Dept Gastroenterol, Sch Med, 79 Qingchun Rd, Hangzhou 310003, Zhejiang, Peoples R China.
EM zlym@zju.edu.cn
RI chen, lijuan/HSE-1019-2023; MA, YAN/HHN-2912-2022
OI Ma, Han/0000-0001-9985-3035
FU National Natural Science Foundation of China [81300303]; Zhejiang
   Provincial Laboratory Animal Science Technology Program of China
   [2011C37088]; Natural Science Foundation of Zhejiang Province, China
   [Y13H030004]
FX Supported by National Natural Science Foundation of China, No. 81300303;
   Zhejiang Provincial Laboratory Animal Science Technology Program of
   China, No. 2011C37088; Natural Science Foundation of Zhejiang Province,
   China, No. Y13H030004
CR Adams LA, 2005, DIABETIC MED, V22, P1129, DOI 10.1111/j.1464-5491.2005.01748.x
   Aguilera E, 2002, TRANSPLANT P, V34, P206, DOI 10.1016/S0041-1345(01)02831-7
   Aller R, 2011, EUR REV MED PHARMACO, V15, P1090
   Basaranoglu M, 1999, J HEPATOL, V31, P384, DOI 10.1016/S0168-8278(99)80243-8
   Brun P, 2007, AM J PHYSIOL-GASTR L, V292, pG518, DOI 10.1152/ajpgi.00024.2006
   Cani PD, 2007, DIABETOLOGIA, V50, P2374, DOI 10.1007/s00125-007-0791-0
   Clark JM, 2006, J CLIN GASTROENTEROL, V40, pS5
   Clark JM, 2006, J CLIN GASTROENTEROL, V40, pS39
   DeRodas BZ, 1996, J DAIRY SCI, V79, P2121, DOI 10.3168/jds.S0022-0302(96)76586-4
   Drakoulis CK, 2004, ATHEROSCLEROSIS, V174, P193, DOI 10.1016/j.atherosclerosis.2004.01.008
   Eckburg PB, 2005, SCIENCE, V308, P1635, DOI 10.1126/science.1110591
   Georgescu EF, 2007, J GASTROINTEST LIVER, V16, P39
   GIBSON GR, 1994, J APPL BACTERIOL, V77, P412, DOI 10.1111/j.1365-2672.1994.tb03443.x
   GIBSON GR, 1995, GASTROENTEROLOGY, V108, P975, DOI 10.1016/0016-5085(95)90192-2
   GIBSON GR, 1995, J NUTR, V125, P1401, DOI 10.1093/jn/125.6.1401
   Gill HS, 2004, POSTGRAD MED J, V80, P516, DOI 10.1136/pgmj.2003.008664
   Gill SR, 2006, SCIENCE, V312, P1355, DOI 10.1126/science.1124234
   GILLILAND SE, 1990, J DAIRY SCI, V73, P905, DOI 10.3168/jds.S0022-0302(90)78747-4
   Guarner F, 2003, LANCET, V361, P512, DOI 10.1016/S0140-6736(03)12489-0
   Henao-Mejia J, 2012, NATURE, V482, P179, DOI 10.1038/nature10809
   Hofacre C. L., 2005, International Poultry Production, V13, P7
   HOTAMISLIGIL GS, 1995, J CLIN INVEST, V95, P2409, DOI 10.1172/JCI117936
   Ibnou-Zekri N, 2003, INFECT IMMUN, V71, P428, DOI 10.1128/IAI.71.1.428-436.2003
   Kaplowitz N, 2000, J HEPATOL, V32, P39, DOI 10.1016/S0168-8278(00)80414-6
   Katz A, 2000, J CLIN ENDOCR METAB, V85, P2402, DOI 10.1210/jc.85.7.2402
   Lee YM, 2008, HEPATOL INT, V2, P196, DOI 10.1007/s12072-008-9058-1
   Ley RE, 2006, NATURE, V444, P1022, DOI 10.1038/4441022a
   LILLY DM, 1965, SCIENCE, V147, P747, DOI 10.1126/science.147.3659.747
   Loguercio C, 2005, J CLIN GASTROENTEROL, V39, P540, DOI 10.1097/01.mcg.0000165671.25272.0f
   Macfarlane GT, 2002, CURR OPIN INFECT DIS, V15, P501, DOI 10.1097/00001432-200210000-00008
   Madsen K, 2001, GASTROENTEROLOGY, V121, P580, DOI 10.1053/gast.2001.27224
   Malaguarnera M, 2010, EUR J GASTROEN HEPAT, V22, P199, DOI 10.1097/MEG.0b013e328330a8d3
   Malaguarnera M, 2012, DIGEST DIS SCI, V57, P545, DOI 10.1007/s10620-011-1887-4
   MALASANOS TH, 1991, DIABETES CARE, V14, P1160, DOI 10.2337/diacare.14.12.1160
   Marchesini G, 2001, LANCET, V358, P893, DOI 10.1016/S0140-6736(01)06042-1
   McCartney AL, 1996, APPL ENVIRON MICROB, V62, P4608, DOI 10.1128/AEM.62.12.4608-4613.1996
   Miele L, 2009, HEPATOLOGY, V49, P1877, DOI 10.1002/hep.22848
   Montecucco Fabrizio, 2008, Endocrine Metabolic & Immune Disorders-Drug Targets, V8, P301, DOI 10.2174/187153008786848268
   Musso G, 2012, DIABETOLOGIA, V55, P885, DOI 10.1007/s00125-011-2446-4
   Nobili V, 2008, HEPATOLOGY, V48, P119, DOI 10.1002/hep.22336
   Pamuk GE, 2003, J GASTROEN HEPATOL, V18, P1220
   Pereira DIA, 2002, CRIT REV BIOCHEM MOL, V37, P259, DOI 10.1080/10409230290771519
   Pinto LD, 2010, LIVER INT, V30, P603, DOI 10.1111/j.1478-3231.2009.02200.x
   Promrat K, 2004, HEPATOLOGY, V39, P188, DOI 10.1002/hep.20012
   Rinella ME, 2009, GASTROENTEROLOGY, V136, pA88
   Rodriguez-Hernandez H, 2011, ANN HEPATOL, V10, P486, DOI 10.1016/S1665-2681(19)31517-0
   Salminen S., 1996, IDF NUTR NEWS LETT, V5, P16
   Socha P, 2009, J PEDIATR GASTR NUTR, V48, P587, DOI 10.1097/MPG.0b013e31818e04d1
   Solga SF, 2003, J HEPATOL, V38, P681, DOI 10.1016/S0168-8278(03)00097-7
   Szabo G, 2010, DIGEST DIS, V28, P737, DOI 10.1159/000324281
   Tannock GW, 2012, ISME J, V6, P927, DOI 10.1038/ismej.2011.161
   Tilg H, 2010, HEPATOLOGY, V52, P1836, DOI 10.1002/hep.24001
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Usman, 2000, J DAIRY SCI, V83, P1705, DOI 10.3168/jds.S0022-0302(00)75039-9
   Uygun A, 2004, ALIMENT PHARM THER, V19, P537, DOI 10.1111/j.1365-2036.2004.01888.x
   Vajro P, 2011, J PEDIATR GASTR NUTR, V52, P740, DOI 10.1097/MPG.0b013e31821f9b85
   Vanni E, 2009, HEPATOLOGY, V49, P1790, DOI 10.1002/hep.23036
   Wigg AJ, 2001, GUT, V48, P206, DOI 10.1136/gut.48.2.206
   Wong VWS, 2013, ANN HEPATOL, V12, P256, DOI 10.1016/S1665-2681(19)31364-X
   Zhang HS, 2009, P NATL ACAD SCI USA, V106, P2365, DOI 10.1073/pnas.0812600106
NR 60
TC 239
Z9 253
U1 3
U2 85
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD OCT 28
PY 2013
VL 19
IS 40
BP 6911
EP 6918
DI 10.3748/wjg.v19.i40.6911
PG 8
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 242WI
UT WOS:000326275100026
PM 24187469
OA Green Published, hybrid, Green Submitted
DA 2023-06-08
ER

PT J
AU Chen, YX
   Wang, MA
AF Chen, Yanxia
   Wang, Mian
TI New Insights of Anti-Hyperglycemic Agents and Traditional Chinese
   Medicine on Gut Microbiota in Type 2 Diabetes
SO DRUG DESIGN DEVELOPMENT AND THERAPY
LA English
DT Review
DE gut microbiota; anti-hyperglycemic agents; traditional Chinese medicine;
   type 2 diabetes mellitus
ID TRIMETHYLAMINE N-OXIDE; DIET-INDUCED OBESITY; CHAIN FATTY-ACIDS;
   METABOLIC ENDOTOXEMIA; RECEPTOR AGONISTS; BARRIER FUNCTION;
   DOUBLE-BLIND; METFORMIN; INFLAMMATION; BERBERINE
AB Type 2 diabetes mellitus (T2DM) is a widespread metabolic disease characterized by chronic hyperglycemia. Human microbiota, which is regarded as a "hidden organ", plays an important role in the initiation and development of T2DM. In addition, anti hyperglycemic agents and traditional Chinese medicine may affect the composition of gut microbiota and consequently improve glucose metabolism. However, the relationship between gut microbiota, T2DM and anti-hyperglycemic agents or traditional Chinese medicine is poorly understood. In this review, we summarized pre-clinical and clinical studies to elucidate the possible underlying mechanism. Some anti-hyperglycemic agents and traditional Chinese medicine may partly exert hypoglycemic effects by altering the gut microbiota composition in ways that reduce metabolic endotoxemia, maintain the integrity of intestinal mucosal barrier, promote the production of short-chain fatty acids (SCFAs), decrease trimethylamine-N-oxide (TMAO) and regulate bile acid metabolism. In conclusion, gut micro biota may provide some new therapeutic targets for treatment of patients with diabetes mellitus.
C1 [Chen, Yanxia; Wang, Mian] Hebei Med Univ, Hosp 2, Dept Endocrinol, 215 Hepingxi Rd, Shijiazhuang 050051, Hebei, Peoples R China.
C3 Hebei Medical University
RP Wang, MA (通讯作者)，Hebei Med Univ, Hosp 2, Dept Endocrinol, 215 Hepingxi Rd, Shijiazhuang 050051, Hebei, Peoples R China.
EM wangmian66@sina.com
RI chen, Yanxia/HCI-8515-2022
OI chen, Yanxia/0000-0001-6153-3503
FU Natural Science Foundation of Hebei Province (CN) [2020206108]
FX This study was funded by Natural Science Foundation of Hebei Province
   (CN) 2020206108.
CR Gonzalez-Regueiro JA, 2017, ANN HEPATOL, V16, pS15, DOI [10.5604/01.3001.0010.5672, 10.5604/01.3001.0010.5494]
   Ali AH, 2015, ANN TRANSL MED, V3, DOI 10.3978/j.issn.2305-5839.2014.12.06
   Alkanani AK, 2014, DIABETES, V63, P619, DOI 10.2337/db13-1007
   Allin KH, 2015, EUR J ENDOCRINOL, V172, pR167, DOI 10.1530/EJE-14-0874
   Baxter NT, 2019, MSPHERE, V4, DOI [10.1128/mSphere.00528-18, 10.1128/msphere.00528-18]
   Boulange CL, 2016, GENOME MED, V8, DOI 10.1186/s13073-016-0303-2
   Bouter KE, 2017, GASTROENTEROLOGY, V152, P1671, DOI 10.1053/j.gastro.2016.12.048
   Bryrup T, 2019, DIABETOLOGIA, V62, P1024, DOI 10.1007/s00125-019-4848-7
   Cani PD, 2012, CLIN MICROBIOL INFEC, V18, P50, DOI 10.1111/j.1469-0691.2012.03866.x
   Cani PD, 2009, GUT, V58, P1091, DOI 10.1136/gut.2008.165886
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Cani PD, 2012, GUT MICROBES, V3, P279, DOI 10.4161/gmic.19625
   Cao MT, 2021, TRANSPLANTATION, V105, P1980, DOI 10.1097/TP.0000000000003603
   Chen C, 2018, FOOD FUNCT, V9, P3732, DOI [10.1039/C7FO01346A, 10.1039/c7fo01346a]
   Chen Jian, 2010, Diabetes Ther, V1, P57, DOI 10.1007/s13300-010-0006-4
   Chen LC, 2019, FOOD FUNCT, V10, P4372, DOI [10.1039/C9FO00406H, 10.1039/c9fo00406h]
   Chen MY, 2018, NUTR METAB, V15, DOI 10.1186/s12986-018-0246-2
   Chen YY, 2019, BBA-MOL BASIS DIS, V1865, P2576, DOI 10.1016/j.bbadis.2019.06.016
   Cheng Y, 2019, INT J BIOL MACROMOL, V131, P1162, DOI 10.1016/j.ijbiomac.2019.04.040
   Christiansen CB, 2018, AM J PHYSIOL-GASTR L, V315, pG53, DOI 10.1152/ajpgi.00346.2017
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Deacon CF, 2020, NAT REV ENDOCRINOL, V16, P642, DOI 10.1038/s41574-020-0399-8
   Deane AM, 2010, J CLIN ENDOCR METAB, V95, P215, DOI 10.1210/jc.2009-1503
   Deutschmann K, 2018, BBA-MOL BASIS DIS, V1864, P1319, DOI 10.1016/j.bbadis.2017.08.021
   Ding L, 2018, LIPIDS HEALTH DIS, V17, DOI 10.1186/s12944-018-0939-6
   Dou YX, 2021, BIOMED PHARMACOTHER, V137, DOI 10.1016/j.biopha.2021.111312
   Drucker DJ, 2006, LANCET, V368, P1696, DOI 10.1016/S0140-6736(06)69705-5
   Du FY, 2018, J PHARMACOL EXP THER, V365, P676, DOI 10.1124/jpet.118.248575
   Duca FA, 2015, NAT MED, V21, P506, DOI 10.1038/nm.3787
   Eckburg PB, 2005, SCIENCE, V308, P1635, DOI 10.1126/science.1110591
   Elbere I, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0241338
   Elbere I, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0204317
   Fajas L, 1997, J BIOL CHEM, V272, P18779, DOI 10.1074/jbc.272.30.18779
   Feng YH, 2018, CELL PHYSIOL BIOCHEM, V49, P190, DOI 10.1159/000492853
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Fuke N, 2019, NUTRIENTS, V11, DOI 10.3390/nu11102277
   Gao BB, 2020, BMC PREGNANCY CHILDB, V20, DOI 10.1186/s12884-020-02961-5
   Gao J, 2018, MED RES REV, V38, P556, DOI 10.1002/med.21447
   Garcia-Beltran C, 2021, PEDIATR OBES, V16, DOI 10.1111/ijpo.12734
   Gomes JMG, 2017, METABOLISM, V68, P133, DOI 10.1016/j.metabol.2016.12.009
   Gilbert MP, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.00178
   Govindarajulu M, 2020, FRONT MOL NEUROSCI, V13, DOI 10.3389/fnmol.2020.00138
   Grice EA, 2012, ANNU REV GENOM HUM G, V13, P151, DOI 10.1146/annurev-genom-090711-163814
   Gu YY, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-01682-2
   Habtemariam S, 2020, PHARMACOL RES, V155, DOI 10.1016/j.phrs.2020.104722
   Hare KJ, 2010, DIABETES, V59, P1765, DOI 10.2337/db09-1414
   Heiss CN, 2018, J INNATE IMMUN, V10, P163, DOI 10.1159/000481519
   Herat LY, 2020, WORLD J GASTROENTERO, V26, DOI 10.3748/wjg.v26.i23.3225
   Hur KY, 2015, J DIABETES INVEST, V6, P600, DOI 10.1111/jdi.12328
   Katsuma S, 2005, BIOCHEM BIOPH RES CO, V329, P386, DOI 10.1016/j.bbrc.2005.01.139
   Kikuchi K, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-09735-4
   Kim JJ, 2010, GASTROENT RES PRACT, V2010, DOI 10.1155/2010/212563
   Koeth RA, 2013, NAT MED, V19, P576, DOI 10.1038/nm.3145
   Kuka J, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-71470-4
   Kuo GH, 2018, BIOORG MED CHEM LETT, V28, P1182, DOI 10.1016/j.bmcl.2018.02.057
   Kyriachenko Y, 2019, WORLD J DIABETES, V10, P154, DOI 10.4239/wjd.v10.i3.154
   Lee DM, 2018, CARDIOVASC DIABETOL, V17, DOI 10.1186/s12933-018-0708-x
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Lent-Schochet D, 2018, HORM MOL BIOL CLIN I, V35, DOI 10.1515/hmbci-2018-0015
   Lever M, 2010, CLIN BIOCHEM, V43, P732, DOI 10.1016/j.clinbiochem.2010.03.009
   Li JN, 2021, FRONT CARDIOVASC MED, V8, DOI 10.3389/fcvm.2021.628471
   Li M, 2020, BIOMED PHARMACOTHER, V132, DOI 10.1016/j.biopha.2020.110953
   Li XX, 2021, NPJ BIOFILMS MICROBI, V7, DOI 10.1038/s41522-021-00205-8
   Li XSM, 2017, EUR HEART J, V38, P814, DOI 10.1093/eurheartj/ehw582
   Liao XY, 2019, EBIOMEDICINE, V44, P665, DOI 10.1016/j.ebiom.2019.03.057
   Liu D, 2018, EXP CLIN ENDOCR DIAB, V126, P513, DOI 10.1055/s-0043-125066
   Liu GM, 2018, INT J BIOL MACROMOL, V115, P711, DOI 10.1016/j.ijbiomac.2018.04.127
   Liu YD, 2021, J FOOD SCI, V86, P546, DOI 10.1111/1750-3841.15575
   Liu ZY, 2017, CHEMMEDCHEM, V12, P819, DOI 10.1002/cmdc.201700216
   Madsen MSA, 2021, BIOMED PHARMACOTHER, V133, DOI 10.1016/j.biopha.2020.110966
   Madsen MSA, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-52103-x
   Martens EC, 2018, NAT REV MICROBIOL, V16, P457, DOI 10.1038/s41579-018-0036-x
   Maruta K, 2020, DIGEST DIS SCI, V65, P2605, DOI 10.1007/s10620-020-06097-6
   Matsumoto M, 2012, AM J OPHTHALMOL, V153, P896, DOI 10.1016/j.ajo.2011.10.006
   McCreight LJ, 2016, DIABETOLOGIA, V59, P426, DOI 10.1007/s00125-015-3844-9
   McGlone ER, 2019, ANN CLIN BIOCHEM, V56, P326, DOI 10.1177/0004563218817798
   Meier JJ, 2012, NAT REV ENDOCRINOL, V8, P728, DOI 10.1038/nrendo.2012.140
   Montandon SA, 2017, GENES-BASEL, V8, DOI 10.3390/genes8100250
   Moran TH, 2005, AM J PHYSIOL-REG I, V288, pR384, DOI 10.1152/ajpregu.00535.2004
   Moreira GV, 2018, J NUTR BIOCHEM, V62, P143, DOI 10.1016/j.jnutbio.2018.07.009
   Nakajima H, 2020, LIFE-BASEL, V10, DOI 10.3390/life10090195
   Nanjan MJ, 2018, BIOORG CHEM, V77, P548, DOI 10.1016/j.bioorg.2018.02.009
   Olivares M, 2018, DIABETOLOGIA, V61, P1838, DOI 10.1007/s00125-018-4647-6
   Pascale A, 2018, ENDOCRINE, V61, P357, DOI 10.1007/s12020-018-1605-5
   Poulsen SB, 2015, CURR OPIN NEPHROL HY, V24, P463, DOI 10.1097/MNH.0000000000000152
   Priyadarshini M, 2018, ENDOCRINOLOGY, V159, P2495, DOI 10.1210/en.2018-00296
   Qin XF, 2005, AM J PHYSIOL-GASTR L, V288, pG943, DOI 10.1152/ajpgi.00303.2004
   Rajani C, 2018, FRONT MED-PRC, V12, P608, DOI 10.1007/s11684-018-0644-x
   Randrianarisoa E, 2016, SCI REP-UK, V6, DOI 10.1038/srep26745
   Romano KA, 2015, MBIO, V6, DOI 10.1128/mBio.02481-14
   Saad MJA, 2016, PHYSIOLOGY, V31, P283, DOI 10.1152/physiol.00041.2015
   Sansome DJ, 2020, DIABETES OBES METAB, V22, P141, DOI 10.1111/dom.13869
   Shang JJ, 2021, PEERJ, V9, DOI 10.7717/peerj.11128
   Shin NR, 2020, AM J PHYSIOL-ENDOC M, V318, pE52, DOI 10.1152/ajpendo.00221.2019
   Smith BJ, 2019, BMC MICROBIOL, V19, DOI 10.1186/s12866-019-1494-7
   Soccio RE, 2014, CELL METAB, V20, P573, DOI 10.1016/j.cmet.2014.08.005
   Su BL, 2015, J DIABETES, V7, P729, DOI 10.1111/1753-0407.12232
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Sun XL, 2016, BIOCHEM BIOPH RES CO, V481, P63, DOI 10.1016/j.bbrc.2016.11.017
   Tai NW, 2015, REV ENDOCR METAB DIS, V16, P55, DOI 10.1007/s11154-015-9309-0
   Thaiss CA, 2018, SCIENCE, V359, P1376, DOI 10.1126/science.aar3318
   Thursby E, 2017, BIOCHEM J, V474, P1823, DOI 10.1042/BCJ20160510
   Tian JX, 2019, DIABETES OBES METAB, V21, P1801, DOI 10.1111/dom.13760
   Tilg H, 2020, NAT REV IMMUNOL, V20, P40, DOI 10.1038/s41577-019-0198-4
   Trabelsi MS, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms8629
   van Bommel EJM, 2020, DIABETES METAB, V46, P164, DOI 10.1016/j.diabet.2019.11.005
   van Bommel EJM, 2017, CLIN J AM SOC NEPHRO, V12, P700, DOI 10.2215/CJN.06080616
   van de Peppel IP, 2020, AM J PHYSIOL-GASTR L, V319, pG619, DOI 10.1152/ajpgi.00308.2020
   Wang K, 2017, DRUG METAB REV, V49, P139, DOI 10.1080/03602532.2017.1306544
   Wang R-R, 2018, J BIOX RES, V1, P41, DOI [10.1097/JBR.0000000000000007, DOI 10.1097/JBR.0000000000000007]
   Wang Y, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.609134
   Wismann P, 2018, PHYSIOL BEHAV, V192, P72, DOI 10.1016/j.physbeh.2018.03.004
   Wu M, 2020, FRONT PHARMACOL, V11, DOI 10.3389/fphar.2020.00223
   Wu TZ, 2016, HANDB EXP PHARMACOL, V233, P137, DOI 10.1007/164_2015_9
   Xiao SW, 2020, APPL MICROBIOL BIOT, V104, P303, DOI 10.1007/s00253-019-10174-w
   Xie C, 2021, NUTRIENTS, V13, DOI 10.3390/nu13041104
   Xie C, 2020, PHARMACEUTICS, V12, DOI 10.3390/pharmaceutics12090790
   Xu GD, 2018, BIOL PHARM BULL, V41, P1024, DOI 10.1248/bpb.b17-00978
   Xu PF, 2017, BBA-GEN SUBJECTS, V1861, P2690, DOI 10.1016/j.bbagen.2017.07.013
   Yan XF, 2016, J DIABETES RES, V2016, DOI 10.1155/2016/2093171
   Yang GL, 2019, J AGR FOOD CHEM, V67, P6169, DOI 10.1021/acs.jafc.9b01270
   Yang HJ, 2020, ENDOCR METAB IMMUNE, V20, P1262, DOI 10.2174/1871530320666200628024500
   Yang QY, 2020, FRONT IMMUNOL, V11, DOI 10.3389/fimmu.2020.590685
   Zhang BX, 2020, EVID-BASED COMPL ALT, V2020, DOI 10.1155/2020/4568629
   Zhang CH, 2019, J ETHNOPHARMACOL, V237, P202, DOI 10.1016/j.jep.2019.02.040
   Zhang NJ, 2020, BIOMED RES INT, V2020, DOI 10.1155/2020/2947549
   Zhang Q, 2018, EXP BIOL MED, V243, P34, DOI 10.1177/1535370217743765
   Zhang RZ, 2020, FRONT PHARMACOL, V11, DOI 10.3389/fphar.2020.00538
   Zhang W, 2019, BIOMED PHARMACOTHER, V118, DOI 10.1016/j.biopha.2019.109131
   Zhang XY, 2017, DIABETES THER, V8, P293, DOI 10.1007/s13300-017-0226-y
   Zhang X, 2012, PLOS ONE, V7, DOI [10.1371/journal.pone.0042529, 10.1371/journal.pone.0035700]
   Zhang YF, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-18414-8
   Zhao FQ, 2020, FOOD CHEM TOXICOL, V135, DOI 10.1016/j.fct.2019.110886
   Zhao L, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00233
   Zheng Y, 2018, NAT REV ENDOCRINOL, V14, P88, DOI 10.1038/nrendo.2017.151
   Zheng YJ, 2021, PHYTOMEDICINE, V88, DOI 10.1016/j.phymed.2020.153455
   Zhong HZ, 2019, EBIOMEDICINE, V47, P373, DOI 10.1016/j.ebiom.2019.08.048
   Zhu L, 2018, ATHEROSCLEROSIS, V268, P117, DOI 10.1016/j.atherosclerosis.2017.11.023
NR 138
TC 3
Z9 4
U1 9
U2 31
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1177-8881
J9 DRUG DES DEV THER
JI Drug Des. Dev. Ther.
PY 2021
VL 15
BP 4849
EP 4863
DI 10.2147/DDDT.S334325
PG 15
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA XH5WY
UT WOS:000725505700005
PM 34876807
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Liu, GM
   Liang, L
   Yu, GY
   Li, QH
AF Liu, Guimei
   Liang, Li
   Yu, Guoyong
   Li, Quanhong
TI Pumpkin polysaccharide modifies the gut microbiota during alleviation of
   type 2 diabetes in rats
SO INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
LA English
DT Article
DE Pumpkin polysaccharide; Gut microbiota; Type 2 diabetes
ID CHAIN FATTY-ACIDS; RESISTANT STARCH; CUCURBITA-PEPO; HOMEOSTASIS;
   GLUCOSE; ENZYMES; HEALTH; ROLES; FIBER; MODEL
AB Pumpkin polysaccharide is able to alleviate diabetes, but understanding of the underlining mechanism is still limited. In this study, we hypothesized that the alleviating effects of pumpkin polysaccharide is modulated via changes in the gut microbiota and short-chain fatty acid (SCFA) production in type 2 diabetic rats. After the type 2 diabetic model successfully was established, three groups of high-fat diet induced diabetic rats were intragastrically administered pumpkin polysaccharide, metformin, or saline solution respectively. We utilized 16S rRNA gene sequencing and multivariate statistics to analyze the structural and key species of gut microbiota in the type 2 diabetic rats. The results revealed that pumpkin polysaccharide alleviated the type 2 diabetes by improving the insulin tolerance and decreasing the levels of serum glucose (GLU), total cholesterol (TC), and low density lipoprotein (LDL-C), while increasing the levels of high-density lipoprotein (HDL-C). Simultaneously, pumpkin polysaccharide changed the structure of gut microbiota and had selective enrichment in key species of Bacteroidetes, Prevotella, Deltaproteobacteria, Oscillospira, Veillonellaceae, Phascolarctobacterium, Sutterella, and Bilophila. The correlations between the key species and SCFA production indicated the underlining mechanisms of pumpkin polysaccharide on type 2 diabetes. (C) 2018 Elsevier B.V. All rights reserved.
C1 [Liu, Guimei; Li, Quanhong] China Agr Univ, Coll Food Sci & Nutr Engn, Beijing Adv Innovat Ctr Food Nutr & Human Hlth, Beijing 100083, Peoples R China.
   [Liu, Guimei; Liang, Li; Yu, Guoyong; Li, Quanhong] Natl Engn Res Ctr Fruit & Vegetable Proc, Beijing 100083, Peoples R China.
   [Liu, Guimei; Liang, Li; Yu, Guoyong; Li, Quanhong] Minist Agr, Key Lab Fruits & Vegetables Proc, Beijing 100083, Peoples R China.
C3 China Agricultural University; Ministry of Agriculture & Rural Affairs
RP Li, QH (通讯作者)，China Agr Univ, Coll Food Sci & Nutr Engn, Beijing Adv Innovat Ctr Food Nutr & Human Hlth, Beijing 100083, Peoples R China.
EM quanhong_li@hotmail.com
FU Beijing Advanced Innovation Center for Food Nutrition and Human Health;
   Fund for Agro-Scientific Research in the Public Interest from the
   Ministry of Agriculture of the People's Republic of China [201303112]
FX We would like to thank Beijing Advanced Innovation Center for Food
   Nutrition and Human Health for their support and the Fund for
   Agro-Scientific Research in the Public Interest (Project No. 201303112)
   from the Ministry of Agriculture of the People's Republic of China.
CR Aguirre M, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0159236
   Cani PD, 2009, GUT, V58, P1091, DOI 10.1136/gut.2008.165886
   Cixous H., 2010, MICROB BIOTECHNOL, V2, P101
   De Vadder F, 2016, CELL METAB, V24, P151, DOI 10.1016/j.cmet.2016.06.013
   Dong Y, 2016, MOLECULES, V21, DOI 10.3390/molecules21111446
   Duncan SH, 2009, ENVIRON MICROBIOL, V11, P2112, DOI 10.1111/j.1462-2920.2009.01931.x
   DY P., 2013, PLOS ONE, V8
   Edgar RC, 2010, BIOINFORMATICS, V26, P2460, DOI 10.1093/bioinformatics/btq461
   El Kaoutari A, 2013, NAT REV MICROBIOL, V11, P497, DOI 10.1038/nrmicro3050
   Gomez B, 2016, J FUNCT FOODS, V20, P108, DOI 10.1016/j.jff.2015.10.029
   Koh A, 2016, CELL, V165, P1332, DOI 10.1016/j.cell.2016.05.041
   Lei Z, 2016, J AGR FOOD CHEM, V64, P4932, DOI 10.1021/acs.jafc.6b01272
   Marti A, 2018, PEDIATR DIABETES, V19, P217, DOI 10.1111/pedi.12561
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   McDonald D, 2012, ISME J, V6, P610, DOI 10.1038/ismej.2011.139
   Miller DN, 1999, APPL ENVIRON MICROB, V65, P4715
   Nasri H, 2014, J RES MED SCI, V19, P658
   Nie Y, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18071372
   Niu Q, 2015, SCI REP-UK, V5, DOI 10.1038/srep09938
   Porter NT, 2017, ANNU REV MICROBIOL, V71, P349, DOI 10.1146/annurev-micro-102215-095316
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Ramette A, 2007, FEMS MICROBIOL ECOL, V62, P142, DOI 10.1111/j.1574-6941.2007.00375.x
   Rosario Rey F, 2006, Curr Diab Rep, V6, P455, DOI 10.1007/s11892-006-0079-7
   Sharp R, 2000, APPL ENVIRON MICROB, V66, P4212, DOI 10.1128/AEM.66.10.4212-4221.2000
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Song Y, 2015, CARBOHYD POLYM, V132, P221, DOI 10.1016/j.carbpol.2015.06.061
   Song Y, 2013, CARBOHYD POLYM, V98, P686, DOI 10.1016/j.carbpol.2013.06.049
   Topping DL, 2001, PHYSIOL REV, V81, P1031, DOI 10.1152/physrev.2001.81.3.1031
   Walker AW, 2005, APPL ENVIRON MICROB, V71, P3692, DOI 10.1128/AEM.71.7.3692-3700.2005
   Wong JMW, 2006, J CLIN GASTROENTEROL, V40, P235, DOI 10.1097/00004836-200603000-00015
   Zhang SW, 2017, EXP THER MED, V14, P383, DOI 10.3892/etm.2017.4475
   Zhang YJ, 2013, INT J BIOL MACROMOL, V62, P574, DOI 10.1016/j.ijbiomac.2013.09.044
   Zhou LB, 2008, ENDOCRINOLOGY, V149, P4510, DOI 10.1210/en.2007-1752
   Zhu HY, 2015, CHIN J NAT MEDICINES, V13, P199, DOI 10.1016/S1875-5364(15)30005-4
NR 34
TC 83
Z9 90
U1 17
U2 195
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0141-8130
EI 1879-0003
J9 INT J BIOL MACROMOL
JI Int. J. Biol. Macromol.
PD AUG
PY 2018
VL 115
BP 711
EP 717
DI 10.1016/j.ijbiomac.2018.04.127
PG 7
WC Biochemistry & Molecular Biology; Chemistry, Applied; Polymer Science
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry; Polymer Science
GA GN0MK
UT WOS:000438662500079
PM 29702167
DA 2023-06-08
ER

PT J
AU Zhang, XY
   Ren, HH
   Zhao, CL
   Shi, Z
   Qiu, L
   Yang, FM
   Zhou, XH
   Han, XY
   Wu, K
   Zhong, HZ
   Li, YF
   Li, JH
   Ji, LN
AF Zhang, Xiuying
   Ren, Huahui
   Zhao, Cuiling
   Shi, Zhun
   Qiu, Li
   Yang, Fangming
   Zhou, Xianghai
   Han, Xueyao
   Wu, Kui
   Zhong, Huanzi
   Li, Yufeng
   Li, Junhua
   Ji, Linong
TI Metagenomic analysis reveals crosstalk between gut microbiota and
   glucose-lowering drugs targeting the gastrointestinal tract in Chinese
   patients with type 2 diabetes: a 6 month, two-arm randomised trial
SO DIABETOLOGIA
LA English
DT Article
DE Glucose-lowering drugs; Gut microbiota; Type 2 diabetes
ID CHAIN FATTY-ACIDS; SECRETION; ACARBOSE; METFORMIN; GLP-1; INHIBITION;
   INSULIN; IMPACT
AB Aims/hypothesis The use of oral glucose-lowering drugs, particularly those designed to target the gut ecosystem, is often observed in association with altered gut microbial composition or functional capacity in individuals with type 2 diabetes. The gut microbiota, in turn, plays crucial roles in the modulation of drug efficacy. We aimed to assess the impacts of acarbose and vildagliptin on human gut microbiota and the relationships between pre-treatment gut microbiota and therapeutic responses.
   Methods This was a randomised, open-labelled, two-arm trial in treatment-naive type 2 diabetes patients conducted in Beijing between December 2016 and December 2017. One hundred participants with overweight/obesity and newly diagnosed type 2 diabetes were recruited from the Pinggu Hospital and randomly assigned to the acarbose (n=50) or vildagliptin (n=50) group using sealed envelopes. The treatment period was 6 months. Blood, faecal samples and visceral fat data from computed tomography images were collected before and after treatments to measure therapeutic outcomes and gut microbiota. Metagenomic datasets from a previous type 2 diabetes cohort receiving acarbose or glipizide for 3 months were downloaded and processed. Statistical analyses were applied to identify the treatment-related changes in clinical variables, gut microbiota and associations.
   Results Ninety-two participants were analysed. After 6 months of acarbose (n=44) or vildagliptin (n=48) monotherapy, both groups achieved significant reductions in HbA(1c) (from 60 to 46 mmol/mol [from 7.65% to 6.40%] in the acarbose group and from 59 to 44mmol/mol [from 7.55% to 6.20%] in the vildagliptin group) and visceral fat areas (all adjusted p values for pre-post comparisons <0.05). Both arms showed drug-specific and shared changes in relative abundances of multiple gut microbial species and pathways, especially the common reductions in Bacteroidetes species. Three months and 6 months of acarbose-induced changes in microbial composition were highly similar in type 2 diabetes patients from the two independent studies. Vildagliptin treatment significantly enhanced fasting active glucagon-like peptide-1 (GLP-1) levels. Baseline gut microbiota, rather than baseline GLP-1 levels, were strongly associated with GLP-1 response to vildagliptin, and to a lesser extent with GLP-1 response to acarbose.
   Conclusions/interpretation This study reveals common microbial responses in type 2 diabetes patients treated with two glucose-lowering drugs targeting the gut differently and acceptable performance of baseline gut microbiota in classifying individuals with different GLP-1 responses to vildagliptin. Our findings highlight bidirectional interactions between gut microbiota and glucose-lowering drugs.
C1 [Zhang, Xiuying; Qiu, Li; Zhou, Xianghai; Han, Xueyao; Ji, Linong] Peking Univ, Peking Univ Peoples Hosp, Dept Endocrinol & Metab, Diabet Ctr, Beijing, Peoples R China.
   [Ren, Huahui; Shi, Zhun; Yang, Fangming; Wu, Kui; Zhong, Huanzi; Li, Junhua] BGI Shenzhen, Shenzhen, Peoples R China.
   [Ren, Huahui] Univ Copenhagen, Dept Biol, Lab Genom & Mol Biomed, Copenhagen, Denmark.
   [Zhao, Cuiling; Li, Yufeng] Capital Med Univ, Dept Endocrinol, Beijing Friendship Hosp, Pinggu Campus, Beijing, Peoples R China.
   [Wu, Kui] BGI Shenzhen, Shenzhen Key Lab Genom, Guangdong Prov Key Lab Human Dis Genom, Shenzhen, Peoples R China.
   [Li, Junhua] BGI Shenzhen, Shenzhen Key Lab Unknown Pathogen Identificat, Shenzhen, Peoples R China.
C3 Peking University; Beijing Genomics Institute (BGI); University of
   Copenhagen; Capital Medical University; Beijing Genomics Institute
   (BGI); Beijing Genomics Institute (BGI)
RP Ji, LN (通讯作者)，Peking Univ, Peking Univ Peoples Hosp, Dept Endocrinol & Metab, Diabet Ctr, Beijing, Peoples R China.; Zhong, HZ; Li, JH (通讯作者)，BGI Shenzhen, Shenzhen, Peoples R China.; Li, YF (通讯作者)，Capital Med Univ, Dept Endocrinol, Beijing Friendship Hosp, Pinggu Campus, Beijing, Peoples R China.; Li, JH (通讯作者)，BGI Shenzhen, Shenzhen Key Lab Unknown Pathogen Identificat, Shenzhen, Peoples R China.
EM zhonghuanzi@genomics.cn; doctorlyf@126.com; lijunhua@genomics.cn;
   jiln@bjmu.edu.cn
RI LI, Junhua/AAG-3919-2019; Zhong, Huanzi/ISA-4702-2023
OI LI, Junhua/0000-0001-6784-1873; ren, huahui/0000-0003-1154-9448
FU National Key Research and Development Project [2016YFC1304901]
FX This work was supported by grants from the National Key Research and
   Development Project (2016YFC1304901).
CR AITCHISON J, 1982, J ROY STAT SOC B, V44, P139
   [Anonymous], 2013, CHIN J ENDOCRINOL ME, V30, P893, DOI DOI 10.3760/CMA.J.ISSN.1000-6699.2014.10.020
   Ashcroft FM, 1999, DIABETOLOGIA, V42, P903, DOI 10.1007/s001250051247
   Batterham RL, 2003, ANN NY ACAD SCI, V994, P162, DOI 10.1111/j.1749-6632.2003.tb03176.x
   Bray GA, 2012, DIABETES CARE, V35, P731, DOI 10.2337/dc11-1299
   Brighton CA, 2015, ENDOCRINOLOGY, V156, P3961, DOI 10.1210/en.2015-1321
   Cao TTB, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.573891
   Christiansen CB, 2018, AM J PHYSIOL-GASTR L, V315, pG53, DOI 10.1152/ajpgi.00346.2017
   CLISSOLD SP, 1988, DRUGS, V35, P214, DOI 10.2165/00003495-198835030-00003
   DiNicolantonio JJ, 2015, OPEN HEART, V2, DOI [10.1136/openhrt-2015-000326, 10.1136/openhrt-2014-000230]
   Enc FY, 2001, AM J PHYSIOL-GASTR L, V281, pG752, DOI 10.1152/ajpgi.2001.281.3.G752
   Fan Y, 2021, NAT REV MICROBIOL, V19, P55, DOI 10.1038/s41579-020-0433-9
   Flatt PR, 2008, FRONT BIOSCI-LANDMRK, V13, P3648, DOI 10.2741/2956
   Franzosa EA, 2018, NAT METHODS, V15, P962, DOI 10.1038/s41592-018-0176-y
   Gu YY, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-01682-2
   Guo W, 2018, CHINESE MED J-PEKING, V131, P1605, DOI 10.4103/0366-6999.235107
   Hanefeld M, 2007, CARDIOVASC DIABETOL, V6, DOI 10.1186/1475-2840-6-20
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kim D, 2017, MICROBIOME, V5, DOI 10.1186/s40168-017-0267-5
   Li Q, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-62224-3
   Liao XY, 2019, EBIOMEDICINE, V44, P665, DOI 10.1016/j.ebiom.2019.03.057
   Louis P, 2009, FEMS MICROBIOL LETT, V294, P1, DOI 10.1111/j.1574-6968.2009.01514.x
   Maier L, 2018, NATURE, V555, P623, DOI 10.1038/nature25979
   Monami M, 2012, ADV THER, V29, P14, DOI 10.1007/s12325-011-0088-z
   Mueller NT, 2021, DIABETES CARE, V44, P1462, DOI 10.2337/dc20-2257
   Muller TD, 2015, MOL METAB, V4, P437, DOI 10.1016/j.molmet.2015.03.005
   Olivares M, 2018, DIABETOLOGIA, V61, P1838, DOI 10.1007/s00125-018-4647-6
   Pearson ER, 2006, NEW ENGL J MED, V355, P467, DOI 10.1056/NEJMoa061759
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Sedighi M, 2017, MICROB PATHOGENESIS, V111, P362, DOI 10.1016/j.micpath.2017.08.038
   Seifarth C, 1998, DIABETIC MED, V15, P485, DOI 10.1002/(SICI)1096-9136(199806)15:6&lt;485::AID-DIA610&gt;3.0.CO;2-Y
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Thomas C, 2009, CELL METAB, V10, P167, DOI 10.1016/j.cmet.2009.08.001
   Tolhurst G, 2012, DIABETES, V61, P364, DOI 10.2337/db11-1019
   Trabelsi MS, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms8629
   Truong DT, 2015, NAT METHODS, V12, P902, DOI 10.1038/nmeth.3589
   Wang L, 2021, FRONT CELL INFECT MI, V11, DOI 10.3389/fcimb.2021.598672
   Wang L, 2016, SCI REP-UK, V6, DOI [10.1038/srep38380, 10.1038/srep33251, 10.1038/srep20004]
   *WHO, 1999, WORLD HLTH REP 1999
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Yang WY, 2014, LANCET DIABETES ENDO, V2, P46, DOI 10.1016/S2213-8587(13)70021-4
   Zhang Q, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0184735
   Zhang YF, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-18414-8
   Zhao L, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00233
   Zheng MY, 2013, CARDIOVASC DIABETOL, V12, DOI 10.1186/1475-2840-12-73
   Zhong HZ, 2019, EBIOMEDICINE, V47, P373, DOI 10.1016/j.ebiom.2019.08.048
NR 46
TC 1
Z9 1
U1 4
U2 11
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0012-186X
EI 1432-0428
J9 DIABETOLOGIA
JI Diabetologia
PD OCT
PY 2022
VL 65
IS 10
BP 1613
EP 1626
DI 10.1007/s00125-022-05768-5
EA AUG 2022
PG 14
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 4O6DC
UT WOS:000836512500001
PM 35930018
OA Green Published, hybrid
DA 2023-06-08
ER

PT J
AU Ding, RX
   Goh, WR
   Wu, RN
   Yue, XQ
   Luo, X
   Khine, WWT
   Wu, JR
   Lee, YK
AF Ding, Rui-xue
   Goh, Wei-Rui
   Wu, Ri-na
   Yue, Xi-qing
   Luo, Xue
   Khine, Wei Wei Thwe
   Wu, Jun-rui
   Lee, Yuan-Kun
TI Revisit gut microbiota and its impact on human health and disease
SO JOURNAL OF FOOD AND DRUG ANALYSIS
LA English
DT Review
DE Gut microbiota; Human health; Disease
ID ABERRANT INTESTINAL MICROBIOTA; SERUM METABOLOME; CANCER; ASSOCIATION;
   PREVENTION; METFORMIN; OBESITY; ATHEROSCLEROSIS; HYPERTENSION;
   TRANSLATION
AB Trillions of microbes have evolved with and continue to live on human beings. With the rapid advances in tools and technology in recent years, new knowledge and insight in cross-talk between the microbes and their hosts have gained. It is the aim of this work to critically review and summarize recent literature reports on the role of microbiota and mechanisms involved in the progress and development of major human diseases, which include obesity, hypertension, cardiovascular disease, diabetes, cancer, Inflammatory Bowel Disease (IBD), gout, depression and arthritis, as well as infant health and longevity. Copyright (C) 2019, Food and Drug Administration, Taiwan. Published by Elsevier Taiwan LLC.
C1 [Ding, Rui-xue; Wu, Ri-na; Yue, Xi-qing; Luo, Xue; Wu, Jun-rui] Shenyang Agr Univ, Coll Food Sci, Shenyang 110866, Liaoning, Peoples R China.
   [Goh, Wei-Rui; Khine, Wei Wei Thwe; Lee, Yuan-Kun] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Microbiol & Immunol, 5 Sci Dr 2, Singapore 117597, Singapore.
C3 Shenyang Agricultural University; National University of Singapore
RP Wu, JR (通讯作者)，Shenyang Agr Univ, Coll Food Sci, Shenyang 110866, Liaoning, Peoples R China.; Lee, YK (通讯作者)，Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Microbiol & Immunol, 5 Sci Dr 2, Singapore 117597, Singapore.
EM junruiwu@126.com; micleeyk@nus.edu.sg
RI Wu, Rina/AFO-3017-2022; Wu, Junrui/AGK-1083-2022
OI Khine, Wei Wei Thwe/0000-0002-7805-9024; Yue, Xiqing/0000-0001-5558-1461
FU Natural Science Foundation of China [31871831, 31471713, 31470538];
   Liaoning BaiQianWan Talents Program Project; Shenyang Science and
   Technology Project [17-189-9-00]; Shenyang Youth Science and Technology
   Innovation Talent Project [RC170212]
FX This study was funded by the Natural Science Foundation of China Grant
   No. 31871831, 31471713, 31470538); Liaoning BaiQianWan Talents Program
   Project, Shenyang Science and Technology Project (Grant No.
   17-189-9-00), Shenyang Youth Science and Technology Innovation Talent
   Project (Grant No. RC170212)
CR Abreu C, 2018, MOL SYST BIOL, V14, DOI 10.15252/msb.20188425
   Adnan S, 2017, PHYSIOL GENOMICS, V49, P96, DOI 10.1152/physiolgenomics.00081.2016
   Allin KH, 2018, DIABETOLOGIA, V61, P810, DOI 10.1007/s00125-018-4550-1
   Bafeta A, 2018, ANN INTERN MED, V169, P240, DOI 10.7326/M18-0343
   Bambury A, 2018, BRIT J PHARMACOL, V15, P1
   Bansilal S, 2015, INT J CARDIOL, V201, pS1, DOI 10.1016/S0167-5273(15)31026-3
   Barrington WT, 2017, NAT REV CARDIOL, V14, P699, DOI 10.1038/nrcardio.2017.169
   Bastiaanssen TFS, 2018, INT J NEUROPSYCHOPH, V2, P1
   Biagi E, 2016, CURR BIOL, V26, P1480, DOI 10.1016/j.cub.2016.04.016
   Bing H, 2017, CELL, V169, P1249
   Bischoff SC, 2017, CLIN NUTR, V36, P917, DOI 10.1016/j.clnu.2016.11.007
   Bunyavanich S, 2016, J ALLERGY CLIN IMMUN, V138, P1122, DOI 10.1016/j.jaci.2016.03.041
   Byrd AL, 2017, SCI TRANSL MED, V9, DOI 10.1126/scitranslmed.aal4651
   Carlson AL, 2018, BIOL PSYCHIAT, V83, P148, DOI 10.1016/j.biopsych.2017.06.021
   Cason CA, 2017, J VASC SURG, V5214, P32378
   Cheng M, 2017, FOOD RES INT, V92, P9, DOI 10.1016/j.foodres.2016.12.008
   Chung L, 2018, CELL HOST MICROBE, V23, P203, DOI [10.1016/j.chom.2018.01.007, 10.1016/j.chom.2018.02.004]
   Dalby MJ, 2017, CELL REP, V21, P1521, DOI 10.1016/j.celrep.2017.10.056
   Damms-Machado A, 2015, BIOMED RES INT, V2015, DOI 10.1155/2015/806248
   Dejea CM, 2018, SCIENCE, V359, P592, DOI 10.1126/science.aah3648
   Di Luccia B, 2018, J FUNCT FOODS, V42, P195, DOI 10.1016/j.jff.2017.12.049
   Dinan TG, 2018, BIOL PSYCHIAT, V83, P97, DOI 10.1016/j.biopsych.2017.11.005
   Durgan DJ, 2016, HYPERTENSION, V67, P469, DOI 10.1161/HYPERTENSIONAHA.115.06672
   Ejtahed HS, 2018, MICROB PATHOGENESIS, V116, P13, DOI 10.1016/j.micpath.2017.12.074
   Fischbach MA, 2018, CELL, V174, P785, DOI 10.1016/j.cell.2018.07.038
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Gibofsky A, 2014, AM J MANAG CARE, V20, pS128
   Gilbert JA, 2018, NAT MED, V24, P392, DOI 10.1038/nm.4517
   Golombos DM, 2018, UROLOGY, V111, P122, DOI 10.1016/j.urology.2017.08.039
   Gonzalez ME, 2016, J AM ACAD DERMATOL, V75, P481, DOI 10.1016/j.jaad.2016.04.066
   Gopalakrishnan V, 2018, SCIENCE, V359, P97, DOI 10.1126/science.aan4236
   Guo Z, 2016, SCI REP-UK, V6, DOI 10.1038/srep20602
   Hall AB, 2017, GENOME MED, V9, DOI 10.1186/s13073-017-0490-5
   Hanninen A, 2018, GUT, V67, P1445, DOI 10.1136/gutjnl-2017-314508
   Hsieh YY, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-017-18596-0
   Huang RX, 2016, NUTRIENTS, V8, DOI 10.3390/nu8080483
   Huc T, 2017, PHARM RES, V130, P172
   Jie ZY, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-00900-1
   Joglekar P, 2017, CELL, V169, P378, DOI 10.1016/j.cell.2017.04.009
   Kashtanova D, 2017, ARTERY RES, V18, P41, DOI 10.1016/j.artres.2017.02.007
   Kashyap PC, 2017, MAYO CLIN PROC, V92, P1855, DOI 10.1016/j.mayocp.2017.10.004
   Kazemi A, 2018, CLIN NUTR, V5614, P30161
   Kelly JR, 2017, BRAIN BEHAV IMMUN, V61, P50, DOI 10.1016/j.bbi.2016.11.018
   Kelly JR, 2016, ANN EPIDEMIOL, V26, P366, DOI 10.1016/j.annepidem.2016.02.008
   Kong FL, 2016, CURR BIOL, V26, pR832, DOI 10.1016/j.cub.2016.08.015
   Kramer CD, 2017, ANAEROBE, V45, P19, DOI 10.1016/j.anaerobe.2017.04.011
   Le Chatelier E, 2013, NATURE, V500, P541, DOI 10.1038/nature12506
   Li J, 2016, CIRCULATION, V133, P2434, DOI 10.1161/CIRCULATIONAHA.115.019645
   Liu RX, 2017, NAT MED, V23, P859, DOI 10.1038/nm.4358
   Liu WJ, 2016, SCI REP-UK, V6, DOI 10.1038/srep34826
   Lloyd-Price J, 2016, GENOME MED, V8, DOI 10.1186/s13073-016-0307-y
   Maeda Y, 2017, J CLIN MED, V6, DOI 10.3390/jcm6060060
   Mardinoglu A, 2016, CELL METAB, V23, P10, DOI 10.1016/j.cmet.2015.12.012
   Matson V, 2018, SCIENCE, V359, P104, DOI 10.1126/science.aao3290
   Matsumoto M, 2017, J FUNCT FOODS, V36, P94, DOI 10.1016/j.jff.2017.06.032
   Mehta RS, 2017, JAMA ONCOL, V3, P921, DOI 10.1001/jamaoncol.2016.6374
   Mell B, 2015, PHYSIOL GENOMICS, V47, P187, DOI 10.1152/physiolgenomics.00136.2014
   Mimee M, 2016, ADV DRUG DELIVER REV, V105, P44, DOI 10.1016/j.addr.2016.04.032
   Mohammed AJ, 2016, CATALYSTS, V6, DOI 10.3390/catal6100163
   Navab-Moghadam F, 2017, MICROB PATHOGENESIS, V110, P630, DOI 10.1016/j.micpath.2017.07.034
   Ng QX, 2018, J AFFECT DISORDERS, V228, P13, DOI 10.1016/j.jad.2017.11.063
   Ortqvist AK, 2019, GUT, V68, P218, DOI 10.1136/gutjnl-2017-314352
   Otstlund-Lagerstrom L, 2016, NUTR J, V15, DOI 10.1186/s12937-016-0198-1
   Pedersen HK, 2016, NATURE, V535, P376, DOI 10.1038/nature18646
   Pinto-Sanchez MI, 2017, GASTROENTEROLOGY, V153, P448, DOI 10.1053/j.gastro.2017.05.003
   Rogier R, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-15802-x
   Rogier R, 2017, MICROBIOME, V5, DOI 10.1186/s40168-017-0278-2
   Scher JU, 2011, NAT REV RHEUMATOL, V7, P569, DOI 10.1038/nrrheum.2011.121
   Sedighi M, 2017, MICROB PATHOGENESIS, V111, P362, DOI 10.1016/j.micpath.2017.08.038
   Sender R, 2016, PLOS BIOL, V14, DOI 10.1371/journal.pbio.1002533
   Shao TJ, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.00268
   Silverman M, 2017, P NATL ACAD SCI USA, V114, P9671, DOI 10.1073/pnas.1712280114
   Sivan A, 2015, SCIENCE, V350, P1084, DOI 10.1126/science.aac4255
   Smolen JS, 2016, LANCET, V388, P1984
   Snyder A, 2015, SCIENCE, V350, P1031, DOI 10.1126/science.aad7706
   Sonnenburg JL, 2016, NATURE, V535, P56, DOI 10.1038/nature18846
   van Nimwegen FA, 2011, J ALLERGY CLIN IMMUN, V128, P948, DOI 10.1016/j.jaci.2011.07.027
   Venturelli OS, 2018, MOL SYST BIOL, V14, DOI 10.15252/msb.20178157
   Vetizou M, 2015, SCIENCE, V350, P1079, DOI 10.1126/science.aad1329
   Wallace CJK, 2017, ANN GEN PSYCHIATR, V16, P1, DOI DOI 10.HTTP://DX.D0I.0RG/10.1186/S12991-017-0138-2
   Wang BH, 2017, ENGINEERING, V3, P71, DOI 10.1016/J.ENG.2017.01.008
   Wang F, 2015, J MICROBIOL BIOTECHN, V25, P1195, DOI 10.4014/jmb.1410.10014
   West CE, 2016, EXPERT REV CLIN IMMU, V12, P625, DOI 10.1586/1744666X.2016.1147955
   Wong SH, 2018, SEMIN CANCER BIOL, V05
   Wong SH, 2017, GASTROENTEROLOGY, V153, P1621, DOI 10.1053/j.gastro.2017.08.022
   World Health Organization, 2016, GLOB REP DIAB EX SUM, P2020
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Yang T, 2015, HYPERTENSION, V65, P1331, DOI 10.1161/HYPERTENSIONAHA.115.05315
   Yang Z, 2016, AMINO ACIDS, V48, P2731, DOI 10.1007/s00726-016-2308-y
   Yanovski SZ, 2018, JAMA-J AM MED ASSOC, V319, P223, DOI 10.1001/jama.2017.20051
   Zhang X, 2015, NAT MED, V21, P895, DOI 10.1038/nm.3914
   Zhang YJ, 2015, INT J MOL SCI, V16, P7493, DOI 10.3390/ijms16047493
   Zheng XJ, 2018, J FOOD BIOCHEM, V42, DOI 10.1111/jfbc.12501
   Zhou DQ, 2014, INT J MOL SCI, V15, P9149, DOI 10.3390/ijms15059149
   Zhu WH, 2018, NATURE, V553, P208, DOI 10.1038/nature25172
NR 95
TC 115
Z9 119
U1 22
U2 90
PU DIGITAL COMMONS BEPRESS
PI BERKELEY
PA 2100 MILVIA ST, STE 300, BERKELEY, CA 94704 USA
SN 1021-9498
J9 J FOOD DRUG ANAL
JI J. Food Drug Anal.
PD JUL
PY 2019
VL 27
IS 3
BP 623
EP 631
DI 10.1016/j.jfda.2018.12.012
PG 9
WC Food Science & Technology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Pharmacology & Pharmacy
GA IJ3CH
UT WOS:000475780800002
PM 31324279
OA hybrid, Green Published
HC Y
HP N
DA 2023-06-08
ER

PT J
AU Stys, LPA
   Bottcher, DE
   Scarparo, RK
   Waltrick, SBG
   de Figueiredo, JAP
   Gomes, MS
   Campos, MM
AF Agostini Stys, Liliana Preto
   Bottcher, Daiana Elisabeth
   Scarparo, Roberta Kochenborger
   Goncalves Waltrick, Silvana Beltrami
   Poli de Figueiredo, Jose Antonio
   Gomes, Maximiliano Schunke
   Campos, Maria Martha
TI Serum levels of inflammatory markers and HbA1c in patients with type 2
   diabetes and apical periodontitis: Preliminary findings
SO AUSTRALIAN ENDODONTIC JOURNAL
LA English
DT Article
DE apical periodontitis; blood glucose; oral health; systemic inflammation;
   type 2 diabetes mellitus
ID ENDODONTIC INFECTION; CHEMOKINE RECEPTORS; GUT MICROBIOTA; MELLITUS;
   RISK; ASSOCIATION; EXPRESSION; CYTOKINES; METFORMIN; OBESITY
AB This pilot study assessed the glycaemic control and the serum levels of inflammatory mediators in type 2 diabetes (T2DM) patients with apical periodontitis (AP). Thirty individuals were divided into four groups: Healthy (H); with AP (AP); with T2DM (T2DM); and with T2DM and AP (T2DM-AP). Demographic and pharmacological data were registered. The body mass index (BMI) and the levels of glycated haemoglobin (HbA1c) and IL-1 beta, IL-6, IL-10, CCL3 and CCL4 were evaluated. AP areas were determined radiographically. Mean age was 64 +/- 12 years, with 63% females. Most T2DM patients were under treatment with metformin and antihypertensives. BMI and H1bAc were significantly higher in T2DM patients in relation to H and AP groups. The AP areas were larger in the T2DM-AP group, compared with the AP group. These preliminary findings suggest no influence of AP on glycaemic control or inflammatory levels amongst T2DM patients, although T2DM increased the AP severity.
C1 [Agostini Stys, Liliana Preto; Bottcher, Daiana Elisabeth; Gomes, Maximiliano Schunke; Campos, Maria Martha] Pontificia Univ Catolica Rio Grande do Sul, Escola Ciencias Saude & Vida, Programa Posgrad Odontol, Porto Alegre, RS, Brazil.
   [Agostini Stys, Liliana Preto; Campos, Maria Martha] Pontificia Univ Catolica Rio Grande do Sul, Ctr Pesquisa Toxicol & Farmacol, Escola Ciencias Saude & Vida, Porto Alegre, RS, Brazil.
   [Bottcher, Daiana Elisabeth; Goncalves Waltrick, Silvana Beltrami; Gomes, Maximiliano Schunke; Campos, Maria Martha] Pontificia Univ Catolica Rio Grande do Sul, Escola Ciencias Saude & Vida, Curso Grad Odontol, Porto Alegre, RS, Brazil.
   [Scarparo, Roberta Kochenborger; Poli de Figueiredo, Jose Antonio] Univ Fed Rio Grande do Sul, Programa Posgrad Odontol, Porto Alegre, RS, Brazil.
   [Gomes, Maximiliano Schunke] Ctr Med & Odontol Policia Mil Rio Grande do Sul, Porto Alegre, RS, Brazil.
C3 Pontificia Universidade Catolica Do Rio Grande Do Sul; Pontificia
   Universidade Catolica Do Rio Grande Do Sul; Pontificia Universidade
   Catolica Do Rio Grande Do Sul; Universidade Federal do Rio Grande do Sul
RP Campos, MM (通讯作者)，Pontificia Univ Catel Rio Grande do Sul, Escola Ciencias Saude & Vida, Ave Ipiranga 6681, BR-90619900 Porto Alegre, RS, Brazil.
EM camposmmartha@yahoo.com
OI Campos, Maria/0000-0001-7738-9892
FU Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq);
   Coordenacao de Aperfeicoamento de N~ivel Superior (CAPES), Brazil [001];
   CNPq, Brazil; Fundacao de Apoio a Pesquisa do Estado do Rio Grande do
   Sul (Brazil) [FAPERGS/PPSUS 002/2013]
FX L.P.A.S is a Mastership student receiving grants from Conselho Nacional
   de Desenvolvimento Cientifico e Tecnologico (CNPq) and supported by
   Coordenacao de Aperfeicoamento de N~ivel Superior (CAPES), Brazil
   (Financial Code 001). J.A.P.F and M.M.C. are researcher career awardees
   of the CNPq, Brazil. The research was financed by Fundacao de Apoio a
   Pesquisa do Estado do Rio Grande do Sul (FAPERGS/PPSUS 002/2013,
   Brazil).
CR Abdolsamadi Hamid Reza, 2008, J Dent Res Dent Clin Dent Prospects, V2, P43, DOI 10.5681/joddd.2008.009
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Amer Diabet Assoc, 2014, DIABETES CARE, V37, pS81, DOI [10.2337/dc13-S067, 10.2337/dc14-S081, 10.2337/dc13-S011, 10.2337/dc10-S062, 10.2337/dc10-S011, 10.2337/dc11-S062, 10.2337/dc12-s064, 10.2337/dc11-S011]
   Cintra LTA, 2016, J ENDODONT, V42, P747, DOI 10.1016/j.joen.2016.01.022
   Bardan R, 2014, CLIN BIOCHEM, V47, P909, DOI 10.1016/j.clinbiochem.2014.02.008
   Borgnakke WS, 2019, DIABETES RES CLIN PR, V157, DOI 10.1016/j.diabres.2019.107839
   Bracks IV, 2014, J ENDODONT, V40, P63, DOI 10.1016/j.joen.2013.09.037
   Braz-Silva PH, 2019, ACTA ODONTOL SCAND, V77, P173, DOI 10.1080/00016357.2018.1521005
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   Cotti E, 2011, J ENDODONT, V37, P1624, DOI 10.1016/j.joen.2011.09.006
   Cotti E, 2011, INT J CARDIOL, V148, P4, DOI 10.1016/j.ijcard.2010.08.011
   D'Aiuto F, 2018, LANCET DIABETES ENDO, V6, P954, DOI [10.1016/S2213-8587(18)30038-X, 10.1016/s2213-8587(18)30038-x]
   De Nunzio C, 2016, NAT REV UROL, V13, P613, DOI 10.1038/nrurol.2016.168
   DEURENBERG P, 1991, BRIT J NUTR, V65, P105, DOI 10.1079/BJN19910073
   Fujita Y, 2017, CURR DIABETES REP, V17, DOI 10.1007/s11892-017-0829-8
   Garrido M, 2019, J ENDODONT, V45, P111, DOI 10.1016/j.joen.2018.11.014
   Georgiou AC, 2019, J ENDODONT, V45, P1279, DOI 10.1016/j.joen.2019.07.017
   Gomes MS, 2013, J ENDODONT, V39, P1205, DOI 10.1016/j.joen.2013.06.014
   Graziani F, 2018, J CLIN PERIODONTOL, V45, P167, DOI 10.1111/jcpe.12837
   Jakovljevic A, 2015, AUST ENDOD J, V41, P72, DOI 10.1111/aej.12072
   Koelink PJ, 2012, PHARMACOL THERAPEUT, V133, P1, DOI 10.1016/j.pharmthera.2011.06.008
   Kopasov AE, 2019, B EXP BIOL MED+, V167, P728, DOI 10.1007/s10517-019-04609-7
   Lai EHH, 2018, J ENDODONT, V44, P1817, DOI 10.1016/j.joen.2018.08.002
   Laumet G, 2018, NEUROPSYCHOPHARMACOL, V43, P2597, DOI 10.1038/s41386-018-0154-1
   Liu CX, 2016, CYTOKINE, V86, P100, DOI 10.1016/j.cyto.2016.06.028
   Liu LS, 2012, J ENDODONT, V38, P943, DOI 10.1016/j.joen.2012.03.010
   Lopez-Lopez J, 2011, J ENDODONT, V37, P598, DOI 10.1016/j.joen.2011.01.002
   Muscogiuri Giovanna, 2019, Int J Obes Suppl, V9, P10, DOI 10.1038/s41367-019-0011-7
   Nah G, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-56662-x
   de Toledo AON, 2019, BRAZ ORAL RES, V33, DOI 10.1590/1807-3107bor-2019.vol33.0093
   Neumann C, 2019, SEMIN IMMUNOL, V44, DOI 10.1016/j.smim.2019.101344
   ORSTAVIK D, 1986, Endodontics and Dental Traumatology, V2, P20
   Pascale A, 2019, CURR OPIN PHARMACOL, V49, P1, DOI 10.1016/j.coph.2019.03.011
   Roomruangwong C., 2019, MOL NEUROBIOL
   Rudranaik Sandeep, 2016, J Clin Exp Dent, V8, pe498
   Saeedi P, 2019, DIABETES RES CLIN PR, V157, DOI 10.1016/j.diabres.2019.107843
   Sasaki H, 2019, J ENDODONT, V45, P181, DOI 10.1016/j.joen.2018.10.007
   Sasaki H, 2016, CURR PHARM DESIGN, V22, P2204, DOI 10.2174/1381612822666160216145107
   Schneider ALC, 2012, AM J EPIDEMIOL, V176, P738, DOI 10.1093/aje/kws156
   Segura-Egea JJ, 2015, INT ENDOD J, V48, P933, DOI 10.1111/iej.12507
   Silva TA, 2005, ORAL MICROBIOL IMMUN, V20, P310, DOI 10.1111/j.1399-302X.2005.00232.x
   Sindhu S, 2017, J DIABETES METAB DIS, V16, DOI 10.1186/s40200-017-0297-3
   Sisli SN, 2019, MED PRIN PRACT, V28, P533, DOI 10.1159/000500472
   Smadi Leena, 2017, J Contemp Dent Pract, V18, P358
   Tsalamandris S, 2019, EUR CARDIOL REV, V14, P50, DOI 10.15420/ecr.2018.33.1
   Verhulst MJL, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00056
   Vidal F, 2016, INT ENDOD J, V49, P1107, DOI 10.1111/iej.12567
   von Elm E, 2007, LANCET, V370, P1453, DOI 10.1016/S0140-6736(07)61602-X
   Wen L, 2017, J NUTR, V147, p1468S, DOI 10.3945/jn.116.240754
   Yip N, 2021, J AM DENT ASSOC, V152, P434, DOI 10.1016/j.adaj.2021.01.005
NR 50
TC 2
Z9 2
U1 2
U2 15
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1329-1947
EI 1747-4477
J9 AUST ENDOD J
JI Aust. Endod. J.
PD APR
PY 2022
VL 48
IS 1
BP 105
EP 115
DI 10.1111/aej.12569
EA OCT 2021
PG 11
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA 0U7PX
UT WOS:000703338700001
PM 34608703
OA Green Published
DA 2023-06-08
ER

PT J
AU Tsai, HJ
   Tsai, WC
   Hung, WC
   Hung, WW
   Chang, CC
   Dai, CY
   Tsai, YC
AF Tsai, Hui-Ju
   Tsai, Wei-Chung
   Hung, Wei-Chun
   Hung, Wei-Wen
   Chang, Chen-Chia
   Dai, Chia-Yen
   Tsai, Yi-Chun
TI Gut Microbiota and Subclinical Cardiovascular Disease in Patients with
   Type 2 Diabetes Mellitus
SO NUTRIENTS
LA English
DT Article
DE type 2 diabetes mellitus; gut microbiota; subclinical cardiovascular
   disease
ID HEART-FAILURE; ASSOCIATION; METAGENOME; METFORMIN; OBESITY; DIET
AB Type 2 diabetes (T2D) is associated with an increased risk of cardiovascular disease (CVD). The gut microbiota may contribute to the onset and progression of T2D and CVD. The aim of this study was to evaluate the relationship between the gut microbiota and subclinical CVD in T2D patients. This cross-sectional study used echocardiographic data to evaluate the cardiac structure and function in T2D patients. We used a quantitative polymerase chain reaction to measure the abundances of targeted fecal bacterial species that have been associated with T2D, including Bacteroidetes, Firmicutes, Clostridium leptum group, Faecalibacterium prausnitzii, Bacteroides, Bifidobacterium, Akkermansia muciniphila, and Escherichia coli. A total of 155 subjects were enrolled (mean age 62.9 +/- 10.1 years; 57.4% male and 42.6% female). Phyla Bacteroidetes and Firmicutes and genera Bacteroides were positively correlated with the left ventricular ejection fraction. Low levels of phylum Firmicutes were associated with an increased risk of left ventricular hypertrophy. High levels of both phylum Bacteroidetes and genera Bacteroides were negatively associated with diastolic dysfunction. A high phylum Firmicutes/Bacteroidetes (F/B) ratio and low level of genera Bacteroides were correlated with an increased left atrial diameter. Phyla Firmicutes and Bacteroidetes, the F/B ratio, and the genera Bacteroides were associated with variations in the cardiac structure and systolic and diastolic dysfunction in T2D patients. These findings suggest that changes in the gut microbiome may be the potential marker of the development of subclinical CVD in T2D patients.
C1 [Tsai, Hui-Ju] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Kaohsiung Municipal Ta Tung Hosp, Dept Family Med, Kaohsiung 801, Taiwan.
   [Tsai, Hui-Ju] Kaohsiung Med Univ, Sch Med, Dept Family Med, Coll Med, Kaohsiung 807, Taiwan.
   [Tsai, Hui-Ju] Kaohsiung Med Univ, Res Ctr Environm Med, Kaohsiung 807, Taiwan.
   [Tsai, Wei-Chung] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Div Cardiol, Dept Internal Med, Kaohsiung 807, Taiwan.
   [Hung, Wei-Chun; Chang, Chen-Chia] Kaohsiung Med Univ, Dept Microbiol & Immunol, Coll Med, Kaohsiung 807, Taiwan.
   [Hung, Wei-Wen] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Div Endocrinol & Metab, Dept Internal Med, Kaohsiung 807, Taiwan.
   [Dai, Chia-Yen; Tsai, Yi-Chun] Kaohsiung Med Univ, Sch Med, Coll Med, Kaohsiung 807, Taiwan.
   [Dai, Chia-Yen] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Div Hepatobiliary, Dept Internal Med, Kaohsiung 807, Taiwan.
   [Tsai, Yi-Chun] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Div Gen Med, Dept Internal Med, Kaohsiung 807, Taiwan.
   [Tsai, Yi-Chun] Kaohsiung Med Univ, Liquid Biopsy & Cohort Res Ctr, Kaohsiung 807, Taiwan.
C3 Kaohsiung Medical University; Kaohsiung Medical University Hospital;
   Kaohsiung Municipal Ta-Tung Hospital; Kaohsiung Medical University;
   Kaohsiung Medical University; Kaohsiung Medical University; Kaohsiung
   Medical University Hospital; Kaohsiung Medical University; Kaohsiung
   Medical University; Kaohsiung Medical University Hospital; Kaohsiung
   Medical University; Kaohsiung Medical University; Kaohsiung Medical
   University Hospital; Kaohsiung Medical University; Kaohsiung Medical
   University Hospital; Kaohsiung Medical University
RP Tsai, YC (通讯作者)，Kaohsiung Med Univ, Sch Med, Coll Med, Kaohsiung 807, Taiwan.; Tsai, YC (通讯作者)，Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Div Gen Med, Dept Internal Med, Kaohsiung 807, Taiwan.; Tsai, YC (通讯作者)，Kaohsiung Med Univ, Liquid Biopsy & Cohort Res Ctr, Kaohsiung 807, Taiwan.
EM bankin_0920@yahoo.com.tw; azygo91@gmail.com; wchung@kmu.edu.tw;
   wacsun@gmail.com; hung4488@ms57.hinet.net; daichiayen@gmail.com;
   lidam65@yahoo.com.tw
OI tsai, yichun/0000-0003-4923-3342; Tsai, Wei Chung/0000-0002-1123-6954;
   Dai, Chia-Yen/0000-0003-2296-3054
FU Ministry of Science and Technology [MOST 110-2314-B-037-056]; Kaohsiung
   Municipal Ta-Tung Hospital [kmtth-109-049]
FX This research was funded by grants from Ministry of Science and
   Technology (MOST 110-2314-B-037-056) and Kaohsiung Municipal Ta-Tung
   Hospital (kmtth-109-049). The funders had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript.
CR Abbate A, 2015, INT J CARDIOL, V179, P430, DOI 10.1016/j.ijcard.2014.11.106
   Bartolomaeus H, 2019, CIRCULATION, V139, P1407, DOI 10.1161/CIRCULATIONAHA.118.036652
   Bertoni AG, 2016, GLOB HEART, V11, P337, DOI 10.1016/j.gheart.2016.07.005
   Branchereau M, 2019, REV ENDOCR METAB DIS, V20, P407, DOI 10.1007/s11154-019-09519-7
   Chang PV, 2014, P NATL ACAD SCI USA, V111, P2247, DOI 10.1073/pnas.1322269111
   Cui L, 2017, BIOMED RES INT, V2017, DOI 10.1155/2017/3796359
   Cui X, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-017-18756-2
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   DEVEREUX RB, 1986, AM J CARDIOL, V57, P450, DOI 10.1016/0002-9149(86)90771-X
   Diamant M, 2011, OBES REV, V12, P272, DOI 10.1111/j.1467-789X.2010.00797.x
   Emoto T, 2017, HEART VESSELS, V32, P39, DOI 10.1007/s00380-016-0841-y
   Fretheim A, 2012, BMC MED, V10, DOI 10.1186/1741-7015-10-33
   Furusawa Y, 2013, NATURE, V504, P446, DOI 10.1038/nature12721
   Guo XL, 2008, ANAEROBE, V14, P224, DOI 10.1016/j.anaerobe.2008.04.001
   Iwakura K, 2019, J ECHOCARDIOGR, V17, P177, DOI 10.1007/s12574-019-00446-9
   Jie ZY, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-00900-1
   Josse J, 2016, J STAT SOFTW, V70
   Hamasaki-Matos AJ, 2021, BMC RES NOTES, V14, DOI 10.1186/s13104-021-05655-z
   Kamo T, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0174099
   KANNEL WB, 1979, JAMA-J AM MED ASSOC, V241, P2035, DOI 10.1001/jama.241.19.2035
   Karlsson CLJ, 2012, OBESITY, V20, P2257, DOI 10.1038/oby.2012.110
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kim J, 2019, FRONT MICROBIOL, V10, DOI 10.3389/fmicb.2019.01947
   Kummen M, 2018, J AM COLL CARDIOL, V71, P1184, DOI 10.1016/j.jacc.2017.12.057
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Le KA, 2013, FRONT PHYSIOL, V3, DOI 10.3389/fphys.2012.00496
   Lehrke M, 2017, AM J CARDIOL, V120, pS37, DOI 10.1016/j.amjcard.2017.05.014
   Li L, 2020, EVID-BASED COMPL ALT, V2020, DOI 10.1155/2020/9097821
   Mamic P, 2021, J MOL CELL CARDIOL, V152, P105, DOI 10.1016/j.yjmcc.2020.12.001
   Mancia G, 2007, EUR HEART J, V28, P1462, DOI [10.1093/eurheartj/ehm236, 10.1093/eurheartj/eht151]
   Marques FZ, 2017, CIRCULATION, V135, P964, DOI [10.1161/CIRCULATIONAHA.116.024545, 10.1161/circulationaha.116.024545]
   Masoudi FA, 2007, AM J CARDIOL, V99, p113B, DOI 10.1016/j.amjcard.2006.11.013
   Mayerhofer CCK, 2020, ESC HEART FAIL, V7, P456, DOI 10.1002/ehf2.12596
   Miele L, 2015, CURR CARDIOL REP, V17, DOI 10.1007/s11886-015-0671-z
   Nagatomo Y, 2015, J CARD FAIL, V21, P973, DOI 10.1016/j.cardfail.2015.09.017
   Navab-Moghadam F, 2017, MICROB PATHOGENESIS, V110, P630, DOI 10.1016/j.micpath.2017.07.034
   Penders J, 2006, PEDIATRICS, V118, P511, DOI 10.1542/peds.2005-2824
   Pluznick JL, 2014, GUT MICROBES, V5, P202, DOI 10.4161/gmic.27492
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Rajilic-Stojanovic M, 2014, FEMS MICROBIOL REV, V38, P996, DOI 10.1111/1574-6976.12075
   Saeedi P, 2019, DIABETES RES CLIN PR, V157, DOI 10.1016/j.diabres.2019.107843
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Sohn DW, 1999, J AM SOC ECHOCARDIOG, V12, P927, DOI 10.1016/S0894-7317(99)70145-8
   Sonnenburg JL, 2016, NATURE, V535, P56, DOI 10.1038/nature18846
   Tang WHW, 2019, NAT REV CARDIOL, V16, P137, DOI 10.1038/s41569-018-0108-7
   Tang WHW, 2017, CIRC RES, V120, P1183, DOI 10.1161/CIRCRESAHA.117.309715
   Tims S, 2013, ISME J, V7, P707, DOI 10.1038/ismej.2012.146
   Troseid M, 2020, EBIOMEDICINE, V52, DOI 10.1016/j.ebiom.2020.102649
   Tsai HJ, 2021, J PERS MED, V11, DOI 10.3390/jpm11030238
   Tsai YC, 2016, SCI REP-UK, V6, DOI 10.1038/srep39400
   Wang H, 2016, HYPERTENSION, V68, P114, DOI 10.1161/HYPERTENSIONAHA.116.07084
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Wu XK, 2010, CURR MICROBIOL, V61, P69, DOI 10.1007/s00284-010-9582-9
   Yoshida N, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-69983-z
   Yuzefpolskaya M, 2020, J HEART LUNG TRANSPL, V39, P880, DOI 10.1016/j.healun.2020.02.004
   Zabell Allyson, 2017, Curr Treat Options Cardiovasc Med, V19, P27, DOI 10.1007/s11936-017-0528-4
   Zhao LP, 2013, NAT REV MICROBIOL, V11, P639, DOI 10.1038/nrmicro3089
   Zhu Q, 2018, PHYSIOL GENOMICS, V50, P893, DOI 10.1152/physiolgenomics.00070.2018
NR 58
TC 14
Z9 15
U1 7
U2 14
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD AUG
PY 2021
VL 13
IS 8
AR 2679
DI 10.3390/nu13082679
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA UH3CJ
UT WOS:000689813300001
PM 34444839
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Palau-Rodriguez, M
   Tulipani, S
   Queipo-Ortuno, MI
   Urpi-Sarda, M
   Tinahones, FJ
   Andres-Lacueva, C
AF Palau-Rodriguez, Magali
   Tulipani, Sara
   Isabel Queipo-Ortuno, Maria
   Urpi-Sarda, Mireia
   Tinahones, Francisco J.
   Andres-Lacueva, Cristina
TI Metabolomic insights into the intricate gut microbial-host interaction
   in the development of obesity and type 2 diabetes
SO FRONTIERS IN MICROBIOLOGY
LA English
DT Review
DE metabolomics; gut microbiota; obesity; type 2 diabetes; co-metabolism
ID BILE-ACID METABOLISM; PROTEIN-COUPLED RECEPTOR; BIOCHEMICAL-CHANGES;
   MELLITUS PATIENTS; CHOLINE; URINARY; ENERGY; DIET; ENDOTOXEMIA;
   CONVERSION
AB Gut microbiota has recently been proposed as a crucial environmental factor in the development of metabolic diseases such as obesity and type 2 diabetes, mainly due to its contribution in the modulation of several processes including host energy metabolism, gut epithelial permeability, gut peptide hormone secretion, and host inflammatory state. Since the symbiotic interaction between the gut microbiota and the host is essentially reflected in specific metabolic signatures, much expectation is placed on the application of metabolomic approaches to unveil the key mechanisms linking the gut microbiota composition and activity with disease development. The present review aims to summarize the gut microbial host co-metabolites identified so far by targeted and untargeted metabolomic studies in humans, in association with impaired glucose homeostasis and/or obesity. An alteration of the co-metabolism of bile acids, branched fatty acids, choline, vitamins (i.e., niacin), purines, and phenolic compounds has been associated so far with the obese or diabese phenotype, in respect to healthy controls. Furthermore, anti-diabetic treatments such as metformin and sulfonylurea have been observed to modulate the gut microbiota or at least their metabolic profiles, thereby potentially affecting insulin resistance through indirect mechanisms still unknown. Despite the scarcity of the metabolomic studies currently available on the microbial host crosstalk, the data-driven results largely confirmed findings independently obtained from in vitro and animal model studies, putting forward the mechanisms underlying the implication of a dysfunctional gut microbiota in the development of metabolic disorders.
C1 [Palau-Rodriguez, Magali; Tulipani, Sara; Urpi-Sarda, Mireia; Andres-Lacueva, Cristina] Univ Barcelona, Biomarkers & Nutrimetabol Lab, Dept Nutr & Food Sci, XaRTA,INSA,Pharm Fac, Barcelona, Spain.
   [Tulipani, Sara; Isabel Queipo-Ortuno, Maria; Tinahones, Francisco J.] Univ Malaga, Malaga Hosp Complex Vigen Victoria, Serv Endocrinol & Nutr, Biomed Res Inst IBIMA, E-29071 Malaga, Spain.
   [Isabel Queipo-Ortuno, Maria; Tinahones, Francisco J.] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBERobn, Madrid, Spain.
C3 University of Barcelona; Instituto de Investigacion Biomedica de Malaga
   y Plataforma en Nanomedicina (IBIMA); Universidad de Malaga; CIBER -
   Centro de Investigacion Biomedica en Red; CIBEROBN; Instituto de Salud
   Carlos III
RP Tulipani, S (通讯作者)，Univ Barcelona, Biomarkers & Nutrimetabol Lab, Dept Nutr & Food Sci, XaRTA,INSA,Pharm Fac, Campus Torribera, Barcelona, Spain.
EM sara.tulipani@ub.edu; candres@ub.edu
RI Andres-Lacueva, Cristina/J-3377-2012; Ortuño, María Isabel
   Queipo/AAC-1238-2021; Urpi-Sarda, Mireia/D-5937-2013; Tinahones,
   Francisco José/AAB-2882-2020; Tulipani, Sara/K-8285-2019
OI Andres-Lacueva, Cristina/0000-0002-8494-4978; Urpi-Sarda,
   Mireia/0000-0002-4064-5175; Tulipani, Sara/0000-0001-5658-8462;
   Tinahones, Francisco J/0000-0001-6871-4403
FU Instituto de Salud Carlos Ill (ISCIII)-Subdireccion General de
   Evaluacion y Fomento de la lnyestigacion [PI13/01172, Plan N de I+D+i
   2013-2016]; Fundacion Progreso y Salud Conscjeria de Salud y Biencstar
   Social; Junta de Andalucia; Fondo Europeo de Desarrollo Regional
   (FEDER); JPI HDHL FOODBALL [PUN 2014 133-MINECO-Spain]; ISCIII-CIBEROBN;
   Generalitat de Catalunya's Agency AGAUR [2014SGR1566]; Juan de la Cierva
   fellowship (MINECO); "Miguel Servo Type I" program of the Instituto de
   Salud Carlos Ill, Madrid, Spain [CP13/00065]; MINECO; Fond Social Europe
FX This research was supported by: the PI13/01172 Project (Plan N de I+D+i
   2013-2016) from the Instituto de Salud Carlos Ill (ISCIII)-Subdireccion
   General de Evaluacion y Fomento de la lnyestigacion, and the
   PI-0557-2013 Project, from Fundacion Progreso y Salud Conscjeria de
   Salud y Biencstar Social, Junta de Andalucia, both cofounded by the
   Fondo Europeo de Desarrollo Regional (FEDER); the JPI HDHL FOODBALL (PUN
   2014 133-MINECO-Spain), and ISCIII-CIBEROBN. We also thank the award of
   2014SGR1566 from the Generalitat de Catalunya's Agency AGAUR. ST
   acknowledges the Juan de la Cierva fellowship (MINECO). MO acknowledges
   support from the "Miguel Servo Type I" program (CP13/00065) of the
   Instituto de Salud Carlos Ill, Madrid, Spain. MU-S acknowledges the
   Ramon y Cajal program from MINECO and Fond Social Europe.
CR Astrup A, 2000, Obes Rev, V1, P57, DOI 10.1046/j.1467-789x.2000.00013.x
   Backhed F, 2005, SCIENCE, V307, P1915, DOI 10.1126/science.1104816
   Backhed F, 2007, P NATL ACAD SCI USA, V104, P979, DOI 10.1073/pnas.0605374104
   Beckonert O, 2010, NAT PROTOC, V5, P1019, DOI 10.1038/nprot.2010.45
   Begley M, 2005, FEMS MICROBIOL REV, V29, P625, DOI 10.1016/j.femsre.2004.09.003
   Blusztajn JK, 1998, SCIENCE, V281, P794, DOI 10.1126/science.281.5378.794
   Calvani R, 2010, INT J OBESITY, V34, P1095, DOI 10.1038/ijo.2010.44
   Campbell C, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0084260
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   Cani PD, 2012, GUT MICROBES, V3, P279, DOI 10.4161/gmic.19625
   Craciun S, 2012, P NATL ACAD SCI USA, V109, P21307, DOI 10.1073/pnas.1215689109
   Delzenne NM, 2011, ANNU REV NUTR, V31, P15, DOI 10.1146/annurev-nutr-072610-145146
   Dewulf EM, 2013, GUT, V62, P1112, DOI 10.1136/gutjnl-2012-303304
   DiBaise JK, 2008, MAYO CLIN PROC, V83, P460, DOI 10.4065/83.4.460
   Du FY, 2013, BIOMARK RES, V1, DOI 10.1186/2050-7771-1-17
   Dumas ME, 2006, P NATL ACAD SCI USA, V103, P12511, DOI 10.1073/pnas.0601056103
   Duncan SH, 2004, BRIT J NUTR, V91, P915, DOI 10.1079/BJN20041150
   Faber Johan H, 2007, J Diabetes Sci Technol, V1, P549
   Fukiya S, 2009, FEMS MICROBIOL LETT, V293, P263, DOI 10.1111/j.1574-6968.2009.01531.x
   Gibson G. R., 2010, Food Science and Technology Bulletin: Functional Foods, V7, P1
   Gipson GT, 2008, MOL BIOSYST, V4, P1015, DOI 10.1039/b807332e
   Guan MM, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0060409
   Hadacek F, 2015, FRONT ENV SCI-SWITZ, V3, DOI 10.3389/fenvs.2015.00012
   Harris K, 2012, J OBES, V2012, DOI 10.1155/2012/879151
   Hofmann AF, 2008, CELL MOL LIFE SCI, V65, P2461, DOI 10.1007/s00018-008-7568-6
   Hosseini E, 2011, NUTR REV, V69, P245, DOI 10.1111/j.1753-4887.2011.00388.x
   Hu FB, 2001, NEW ENGL J MED, V345, P790, DOI 10.1056/NEJMoa010492
   Huang CF, 2013, DIABETES CARE, V36, P1729, DOI 10.2337/dc12-1067
   Huo TG, 2015, BIOMED CHROMATOGR, V29, P115, DOI 10.1002/bmc.3247
   Huo TG, 2009, J PHARMACEUT BIOMED, V49, P976, DOI 10.1016/j.jpba.2009.01.008
   Jones ML, 2014, EXPERT OPIN BIOL TH, V14, P467, DOI 10.1517/14712598.2014.880420
   Kawamata Y, 2003, J BIOL CHEM, V278, P9435, DOI 10.1074/jbc.M209706200
   Koeth RA, 2013, NAT MED, V19, P576, DOI 10.1038/nm.3145
   Kootte RS, 2012, DIABETES OBES METAB, V14, P112, DOI 10.1111/j.1463-1326.2011.01483.x
   Kurland IJ, 2013, ANN NY ACAD SCI, V1287, P1, DOI 10.1111/nyas.12116
   Labbe A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0115175
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Lefebvre P, 2009, PHYSIOL REV, V89, P147, DOI 10.1152/physrev.00010.2008
   Lever M, 2010, CLIN BIOCHEM, V43, P732, DOI 10.1016/j.clinbiochem.2010.03.009
   Ley RE, 2005, P NATL ACAD SCI USA, V102, P11070, DOI 10.1073/pnas.0504978102
   Ley RE, 2006, NATURE, V444, P1022, DOI 10.1038/4441022a
   Li M, 2008, P NATL ACAD SCI USA, V105, P2117, DOI 10.1073/pnas.0712038105
   Llorach R, 2012, J AGR FOOD CHEM, V60, P8797, DOI 10.1021/jf301142b
   Messana I, 1998, CLIN CHEM, V44, P1529
   Micha R, 2010, CIRCULATION, V121, P2271, DOI 10.1161/CIRCULATIONAHA.109.924977
   MIDTVEDT T, 1974, AM J CLIN NUTR, V27, P1341, DOI 10.1093/ajcn/27.11.1341
   Mokdad AH, 2001, JAMA-J AM MED ASSOC, V289, P76, DOI DOI 10.1001/JAMA.289.1.76
   Moreno-Indias I, 2014, FRONT MICROBIOL, V5, DOI 10.3389/fmicb.2014.00190
   Moreno-Navarrete JM, 2012, INT J OBESITY, V36, P1442, DOI 10.1038/ijo.2011.256
   Musso G, 2010, DIABETES CARE, V33, P2277, DOI 10.2337/dc10-0556
   Nguyen A, 2008, CELL SIGNAL, V20, P2180, DOI 10.1016/j.cellsig.2008.06.014
   Nicholson JK, 2012, SCIENCE, V336, P1262, DOI 10.1126/science.1223813
   Piche T, 2003, GASTROENTEROLOGY, V124, P894, DOI 10.1053/gast.2003.50159
   Poirier P, 2006, CIRCULATION, V113, P898, DOI 10.1161/CIRCULATIONAHA.106.171016
   Prawitt J, 2011, CURR DIABETES REP, V11, P160, DOI 10.1007/s11892-011-0187-x
   Psychogios N, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0016957
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Ridlon JM, 2006, J LIPID RES, V47, P241, DOI 10.1194/jlr.R500013-JLR200
   Romano KA, 2015, MBIO, V6, DOI 10.1128/mBio.02481-14
   Salek RM, 2007, PHYSIOL GENOMICS, V29, P99, DOI 10.1152/physiolgenomics.00194.2006
   Samuel BS, 2008, P NATL ACAD SCI USA, V105, P16767, DOI 10.1073/pnas.0808567105
   Sanz Y, 2013, PHARMACOL RES, V69, P144, DOI 10.1016/j.phrs.2012.10.021
   Scalbert A, 2009, METABOLOMICS, V5, P435, DOI 10.1007/s11306-009-0168-0
   Schwiertz A, 2010, OBESITY, V18, P190, DOI 10.1038/oby.2009.167
   Shen J, 2013, MOL ASPECTS MED, V34, P39, DOI 10.1016/j.mam.2012.11.001
   Shoaie S, 2015, CELL METAB, V22, P320, DOI 10.1016/j.cmet.2015.07.001
   Suhre K, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0013953
   Sun LA, 2010, DIABETES CARE, V33, P1925, DOI 10.2337/dc10-0340
   Swann JR, 2011, P NATL ACAD SCI USA, V108, P4523, DOI 10.1073/pnas.1006734107
   Thomas C, 2008, NAT REV DRUG DISCOV, V7, P678, DOI 10.1038/nrd2619
   Thomas C, 2009, CELL METAB, V10, P167, DOI 10.1016/j.cmet.2009.08.001
   Tilg H, 2009, GASTROENTEROLOGY, V136, P1476, DOI 10.1053/j.gastro.2009.03.030
   Tremaroli V, 2012, NATURE, V489, P242, DOI 10.1038/nature11552
   Turnbaugh PJ, 2009, J PHYSIOL-LONDON, V587, P4153, DOI 10.1113/jphysiol.2009.174136
   Venema K, 2010, CURR OPIN CLIN NUTR, V13, P432, DOI 10.1097/MCO.0b013e32833a8b60
   Vrieze A, 2010, DIABETOLOGIA, V53, P606, DOI 10.1007/s00125-010-1662-7
   Vrieze A, 2014, J HEPATOL, V60, P824, DOI 10.1016/j.jhep.2013.11.034
   Wang ZN, 2011, NATURE, V472, P57, DOI 10.1038/nature09922
   Warrier M, 2015, CELL REP, V10, P326, DOI 10.1016/j.celrep.2014.12.036
   Watanabe M, 2006, NATURE, V439, P484, DOI 10.1038/nature04330
   Wei L, 2008, TOXICOL APPL PHARM, V227, P417, DOI 10.1016/j.taap.2007.11.015
   Won EY, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0075998
   World Health Organization, 2013, OB OV, P311
   Zeisel SH, 2000, NUTRITION, V16, P669, DOI 10.1016/S0899-9007(00)00349-X
   Zhang XY, 2009, J PROTEOME RES, V8, P5188, DOI 10.1021/pr900524z
   Zhao XJ, 2010, METABOLOMICS, V6, P362, DOI 10.1007/s11306-010-0203-1
NR 86
TC 93
Z9 95
U1 7
U2 102
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1664-302X
J9 FRONT MICROBIOL
JI Front. Microbiol.
PD OCT 27
PY 2015
VL 6
AR 1151
DI 10.3339/fmicb.2075.07751
PG 12
WC Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology
GA CV3OH
UT WOS:000364168000001
PM 26579078
DA 2023-06-08
ER

PT J
AU Xu, XZ
   Gao, ZZ
   Yang, FQ
   Yang, YY
   Chen, L
   Han, L
   Zhao, N
   Xu, JY
   Wang, XM
   Ma, Y
   Shu, L
   Hu, XX
   Lyu, N
   Pan, YL
   Zhu, BL
   Zhao, LH
   Tong, XL
   Wang, J
AF Xu, Xizhan
   Gao, Zezheng
   Yang, Fuquan
   Yang, Yingying
   Chen, Liang
   Han, Lin
   Zhao, Na
   Xu, Jiayue
   Wang, Xinmiao
   Ma, Yue
   Shu, Lian
   Hu, Xiaoxi
   Lyu, Na
   Pan, Yuanlong
   Zhu, Baoli
   Zhao, Linhua
   Tong, Xiaolin
   Wang, Jun
TI Antidiabetic Effects of Gegen Qinlian Decoction via the Gut Microbiota
   Are Attributable to Its Key Ingredient Berberine
SO GENOMICS PROTEOMICS & BIOINFORMATICS
LA English
DT Article
DE Gut microbiota; Type 2 diabetes mellitus; Traditional Chinese medicine;
   Berberine; Gegen Qinlian Decoction
ID METFORMIN ALTERS; TYPE-2; BUTYRATE; GLUCOSE; INFLAMMATION; HOMEOSTASIS;
   METABOLITES; ACTIVATION; METAGENOME; OBESITY
AB Gegen Qinlian Decoction (GQD), a traditional Chinese medicine (TCM) formula, has long been used for the treatment of common metabolic diseases, including type 2 diabetes mellitus. However, the main limitation of its wider application is ingredient complexity of this formula. Thus, it is critically important to identify the major active ingredients of GQD and to illustrate mecha-nisms underlying its action. Here, we compared the effects of GQD and berberine, a hypothetical key active pharmaceutical ingredient of GQD, on a diabetic rat model by comprehensive analyses of gut microbiota, short-chain fatty acids, proinflammatory cytokines, and ileum transcriptomics. Our results show that berberine and GQD had similar effects on lowering blood glucose levels, modulating gut microbiota, inducing ileal gene expression, as well as relieving systemic and local inflammation. As expected, both berberine and GQD treatment significantly altered the overall gut microbiota structure and enriched many butyrate-producing bacteria, including Faecalibacterium and Roseburia, thereby attenuating intestinal inflammation and lowering glucose. Levels of short-chain fatty acids in rat feces were also significantly elevated after treatment with berberine or GQD. Moreover, concentration of serum proinflammatory cytokines and expression of immune-related genes, including Nfkb1, Stat1, and Ifnrg1, in pancreatic islets were significantly reduced after treatment. Our study demonstrates that the main effects of GQD can be attributed to berberine via modulating gut microbiota. The strategy employed would facilitate further standardization and widespread application of TCM in many diseases.
C1 [Xu, Xizhan; Chen, Liang; Zhao, Na; Xu, Jiayue; Ma, Yue; Hu, Xiaoxi; Lyu, Na; Pan, Yuanlong; Zhu, Baoli; Wang, Jun] Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing 100049, Peoples R China.
   [Xu, Xizhan; Ma, Yue; Shu, Lian; Wang, Jun] Univ Chinese Acad Sci, Beijing 100049, Peoples R China.
   [Gao, Zezheng; Yang, Yingying; Han, Lin; Wang, Xinmiao; Zhao, Linhua; Tong, Xiaolin] China Acad Chinese Med Sci, Guanganmen Hosp, Dept Endocrinol, Beijing 100053, Peoples R China.
   [Gao, Zezheng; Yang, Yingying] Beijing Univ Chinese Med, Beijing 100029, Peoples R China.
   [Yang, Fuquan; Shu, Lian] Chinese Acad Sci, Inst Biophys, Lab Prot & Peptide Pharmaceut, Beijing 100101, Peoples R China.
   [Yang, Fuquan; Shu, Lian] Chinese Acad Sci, Inst Biophys, Lab Prote, Beijing 100101, Peoples R China.
   [Tong, Xiaolin] Guangzhou Univ Chinese Med, Shenzhen Hosp, Shenzhen 518034, Peoples R China.
C3 Chinese Academy of Sciences; Chinese Academy of Sciences; University of
   Chinese Academy of Sciences, CAS; China Academy of Chinese Medical
   Sciences; Guang'anmen Hospital, CACMS; Beijing University of Chinese
   Medicine; Chinese Academy of Sciences; Institute of Biophysics, CAS;
   Chinese Academy of Sciences; Institute of Biophysics, CAS; Guangzhou
   University of Chinese Medicine
RP Wang, J (通讯作者)，Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing 100049, Peoples R China.; Wang, J (通讯作者)，Univ Chinese Acad Sci, Beijing 100049, Peoples R China.; Zhao, LH; Tong, XL (通讯作者)，China Acad Chinese Med Sci, Guanganmen Hosp, Dept Endocrinol, Beijing 100053, Peoples R China.; Tong, XL (通讯作者)，Guangzhou Univ Chinese Med, Shenzhen Hosp, Shenzhen 518034, Peoples R China.
EM melonzhao@163.com; tongxiaoli@vip.163.com; junwang@im.ac.cn
RI Chen, Liang/AES-9965-2022; Xu, Xizhan/C-4259-2018; Yang,
   Ying/ABD-2481-2022; Yang, Fuquan/A-6501-2015
OI Chen, Liang/0000-0002-5706-6559; Xu, Xizhan/0000-0003-0777-7659; Yang,
   Yingying/0000-0002-3859-5244; Hu, Xiaoxi/0000-0002-8696-9001; Zhao,
   Na/0000-0001-9523-6072; Ma, Yue/0000-0001-8989-2786; Shu,
   Lian/0000-0002-4315-5630; Yang, Fuquan/0000-0002-2841-5342
FU Strategic Priority Research Program of Chinese Academy of Sciences
   [XDB29020000]; National Key R&D Program of China [2018YFC2000500];
   National Natural Science Foundation of China [81704067, 81430097,
   31771481]
FX This work was supported by the Strategic Priority Research Program of
   Chinese Academy of Sciences (Grant No. XDB29020000), the National Key
   R&D Program of China (Grant No. 2018YFC2000500), and the National
   Natural Science Foundation of China (Grant Nos. 81704067, 81430097, and
   31771481). We are grateful for Liang Zhong from Institute of
   Microbiology, Chinese Academy of Sciences for constructive discussions.
CR Anders S, 2015, BIOINFORMATICS, V31, P166, DOI 10.1093/bioinformatics/btu638
   Backhed F, 2004, P NATL ACAD SCI USA, V101, P15718, DOI 10.1073/pnas.0407076101
   Bailey CJ, 2017, DIABETOLOGIA, V60, P1566, DOI 10.1007/s00125-017-4318-z
   Bauer PV, 2018, CELL METAB, V27, P101, DOI 10.1016/j.cmet.2017.09.019
   Camp JG, 2014, GENOME RES, V24, P1504, DOI 10.1101/gr.165845.113
   Camp JG, 2012, PLOS GENET, V8, DOI 10.1371/journal.pgen.1002585
   Cani PD, 2007, DIABETOLOGIA, V50, P2374, DOI 10.1007/s00125-007-0791-0
   Cheng XW, 2014, SCI REP-UK, V4, DOI 10.1038/srep05147
   Cho NH, 2018, DIABETES RES CLIN PR, V138, P271, DOI 10.1016/j.diabres.2018.02.023
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   De Vadder F, 2014, CELL, V156, P84, DOI 10.1016/j.cell.2013.12.016
   DeFronzo RA, 2015, INT TXB DIABETES MEL, V4th
   Dewulf EM, 2013, GUT, V62, P1112, DOI 10.1136/gutjnl-2012-303304
   El Aidy S, 2012, MUCOSAL IMMUNOL, V5, P567, DOI 10.1038/mi.2012.32
   Falony G, 2016, SCIENCE, V352, P560, DOI 10.1126/science.aad3503
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Janssen AWF, 2018, DIABETOLOGIA, V61, P1447, DOI 10.1007/s00125-018-4583-5
   Jung TH, 2015, NUTR RES PRACT, V9, P343, DOI 10.4162/nrp.2015.9.4.343
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kim D, 2015, NAT METHODS, V12, P357, DOI [10.1038/NMETH.3317, 10.1038/nmeth.3317]
   Kleinert M, 2018, NAT REV ENDOCRINOL, V14, P140, DOI 10.1038/nrendo.2017.161
   Koh A, 2016, CELL, V165, P1332, DOI 10.1016/j.cell.2016.05.041
   Kong WJ, 2004, NAT MED, V10, P1344, DOI 10.1038/nm1135
   Lackey DE, 2016, NAT REV ENDOCRINOL, V12, P15, DOI 10.1038/nrendo.2015.189
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Larsson E, 2012, GUT, V61, P1124, DOI 10.1136/gutjnl-2011-301104
   Le Chatelier E, 2013, NATURE, V500, P541, DOI 10.1038/nature12506
   Ley RE, 2005, P NATL ACAD SCI USA, V102, P11070, DOI 10.1073/pnas.0504978102
   Li BG, 2019, CELL REP, V26, P2720, DOI 10.1016/j.celrep.2019.02.015
   Li QW, 2018, MEDIAT INFLAMM, V2018, DOI 10.1155/2018/9830939
   Li Ying-meng, 2013, Yaoxue Xuebao, V48, P1415
   Li YB, 2016, CHIN J NAT MEDICINES, V14, P813, DOI 10.1016/S1875-5364(16)30098-X
   Liu TT, 2015, SCI REP-UK, V5, DOI 10.1038/srep13982
   Love MI, 2014, GENOME BIOL, V15, DOI 10.1186/s13059-014-0550-8
   Lv J, 2019, CELL DEATH DIS, V10, DOI 10.1038/s41419-019-1638-6
   Magoc T, 2011, BIOINFORMATICS, V27, P2957, DOI 10.1093/bioinformatics/btr507
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Peng LY, 2009, J NUTR, V139, P1619, DOI 10.3945/jn.109.104638
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Richards AL, 2016, MSYSTEMS, V1, DOI 10.1128/mSystems.00067-16
   Rios-Covian D, 2016, FRONT MICROBIOL, V7, DOI 10.3389/fmicb.2016.00185
   Saisho Y, 2015, ENDOCR METAB IMMUNE, V15, P196, DOI 10.2174/1871530315666150316124019
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Singh N, 2014, IMMUNITY, V40, P128, DOI 10.1016/j.immuni.2013.12.007
   Sokol H, 2008, P NATL ACAD SCI USA, V105, P16731, DOI 10.1073/pnas.0804812105
   Sommer F, 2015, GENOME BIOL, V16, DOI 10.1186/s13059-015-0614-4
   Sonnenburg JL, 2016, NATURE, V535, P56, DOI 10.1038/nature18846
   Tong XL, 2011, J TRADIT CHIN MED, V31, P56, DOI 10.1016/S0254-6272(11)60013-7
   Tong XL, 2018, MBIO, V9, DOI 10.1128/mBio.02392-17
   Wang JF, 2018, GUT, V67, P1614, DOI 10.1136/gutjnl-2018-315988
   Wang Q, 2007, APPL ENVIRON MICROB, V73, P5261, DOI 10.1128/AEM.00062-07
   Wang Y, 2017, METABOLISM, V70, P72, DOI 10.1016/j.metabol.2017.02.003
   Wang YQ, 2017, GENOM PROTEOM BIOINF, V15, P14, DOI 10.1016/j.gpb.2017.01.001
   Winer DA, 2017, J CLIN INVEST, V127, P33, DOI 10.1172/JCI88879
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Xie WD, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0024520
   Xu J, 2015, ISME J, V9, P552, DOI 10.1038/ismej.2014.177
   Yu GC, 2012, OMICS, V16, P284, DOI 10.1089/omi.2011.0118
   Zhang CH, 2013, PHYTOMEDICINE, V20, P221, DOI 10.1016/j.phymed.2012.11.002
   Zhang X, 2015, SCI REP-UK, V5, DOI 10.1038/srep14405
   Zhang X, 2012, PLOS ONE, V7, DOI [10.1371/journal.pone.0042529, 10.1371/journal.pone.0035700]
   Zhang YF, 2008, J CLIN ENDOCR METAB, V93, P2559, DOI 10.1210/jc.2007-2404
   Zhang ZG, 2014, NAT COMMUN, V5, DOI 10.1038/ncomms6493
   Zhao LP, 2018, SCIENCE, V359, P1151, DOI 10.1126/science.aao5774
   Zhou X, 2016, FRONT PHARMACOL, V7, DOI 10.3389/fphar.2016.00201
NR 65
TC 53
Z9 60
U1 13
U2 64
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1672-0229
EI 2210-3244
J9 GENOM PROTEOM BIOINF
JI Genom. Proteomics Bioinformatics
PD DEC
PY 2020
VL 18
IS 6
BP 721
EP 736
DI 10.1016/j.gpb.2019.09.0071672-0229
PG 16
WC Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity
GA UC8GN
UT WOS:000686760500008
PM 33359679
DA 2023-06-08
ER

PT J
AU Wei, ZH
   Shen, PL
   Cheng, P
   Lu, Y
   Wang, AY
   Sun, ZG
AF Wei, Zhonghong
   Shen, Peiliang
   Cheng, Peng
   Lu, Yin
   Wang, Aiyun
   Sun, Zhiguang
TI Gut Bacteria Selectively Altered by Sennoside A Alleviate Type 2
   Diabetes and Obesity Traits
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID INSULIN-RESISTANCE; ADIPOSE-TISSUE; LOCAL PROLIFERATION; MICROBIOTA;
   ACTIVATION; ACID; PHARMACOLOGY; RESILIENCE; METABOLISM; LIGANDS
AB Accumulating evidences implicate that gut microbiota play an important role in the onset and prolongation of fat inflammation and diabetes. Sennoside A, the main active ingredient of Rhizoma Rhei (rhubarb), is widely used for constipation as a kind of anthranoid laxative (e.g., senna). Here, we put forward the hypothesis that the structural alteration of gut microbiota in obesity mice may be involved in the pathogenesis of type 2 diabetes (T2D) which may be ameliorated by Sennoside A. We investigated the appearance of obesity, insulin resistance, host inflammation, and leaky gut phenotype with or without Sennoside A indb/dbmice. Horizontal fecal microbiota transplantation (FMT) was used to confirm the critical roles of gut microbiota in the amelioration of the indices in T2D mice after Sennoside A treatment. As a result, we found that Sennoside A administration markedly improved the indices in T2D mice and obesity-related traits including blood glucose level, body weight, lipid metabolism disorder, and insulin resistance. The gut microbiota changed quickly during the onset of T2D indb/dbmice, which confirmed the hypothesis that gut microbiota was involved in the pathogenesis of T2D. Sennoside A altered gut microbial composition which might mediate the antiobesogenic effects in T2D remission. Sennoside A also reduced inflammation and increased tight junction proteins in the ileum in gene-deficient mice via gut microbiota alteration. FMT lowered the blood glucose level and improved insulin resistance, corroborating that Sennoside A perhaps exerted its antiobesogenic effects through gut microbiota alteration.Chemical Compounds Studied in This Article.Compounds studied in this article include Sennoside A (PubChem CID: 73111) and metformin hydrochloride (PubChem CID: 14219).
C1 [Wei, Zhonghong; Shen, Peiliang; Cheng, Peng; Lu, Yin; Wang, Aiyun] Nanjing Univ Chinese Med, Sch Pharm, Jiangsu Key Lab Pharmacol & Safety Evaluat Chines, Nanjing 210023, Peoples R China.
   [Sun, Zhiguang] Nanjing Univ Chinese Med, Jiangsu Prov Chinese Med Hosp 2, Affiliated Hosp 2, Nanjing 210017, Peoples R China.
C3 Nanjing University of Chinese Medicine; Nanjing University of Chinese
   Medicine
RP Wang, AY (通讯作者)，Nanjing Univ Chinese Med, Sch Pharm, Jiangsu Key Lab Pharmacol & Safety Evaluat Chines, Nanjing 210023, Peoples R China.; Sun, ZG (通讯作者)，Nanjing Univ Chinese Med, Jiangsu Prov Chinese Med Hosp 2, Affiliated Hosp 2, Nanjing 210017, Peoples R China.
EM wangaiyun@njucm.edu.cn; zhiguangsun@sina.com
RI Rodríguez, César/ISB-6652-2023; CHENG, PENG/HNP-4206-2023
FU National Natural Science Foundation of China [81973734, 81673725,
   81673795]
FX We thank Dr. Qi Jia for procuring the reagents and Dr. Suyun Yu for
   LEfSe analysis. This project was supported in part by the National
   Natural Science Foundation of China (81973734, 81673725, and 81673795).
CR Aatsinki SM, 2014, BRIT J PHARMACOL, V171, P2351, DOI 10.1111/bph.12585
   Amano SU, 2014, CELL METAB, V19, P162, DOI 10.1016/j.cmet.2013.11.017
   [Anonymous], CHINESE J INTEGRATED
   Boutagy NE, 2016, BIOCHIMIE, V124, P11, DOI 10.1016/j.biochi.2015.06.020
   Cai DS, 2005, NAT MED, V11, P183, DOI 10.1038/nm1166
   Carvalho BM, 2012, DIABETOLOGIA, V55, P2823, DOI 10.1007/s00125-012-2648-4
   Choi SB, 2006, LIFE SCI, V78, P934, DOI 10.1016/j.lfs.2005.05.101
   Cirstea M, 2018, CELL HOST MICROBE, V23, P10, DOI 10.1016/j.chom.2017.12.008
   Curro D, 2017, BRIT J PHARMACOL, V174, P1426, DOI 10.1111/bph.13632
   Dasu MR, 2010, DIABETES CARE, V33, P861, DOI 10.2337/dc09-1799
   de Groot PF, 2017, GUT MICROBES, V8, P253, DOI 10.1080/19490976.2017.1293224
   Despres JP, 2006, NATURE, V444, P881, DOI 10.1038/nature05488
   Donath MY, 2011, NAT REV IMMUNOL, V11, P98, DOI 10.1038/nri2925
   Dong XX, 2016, PHYTOTHER RES, V30, P1207, DOI 10.1002/ptr.5631
   Drolia R, 2018, CELL HOST MICROBE, V23, P470, DOI 10.1016/j.chom.2018.03.004
   Du M, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-02229-1
   Fernandez-Veledo Sonia, 2009, Archives of Physiology and Biochemistry, V115, P227, DOI 10.1080/13813450903164330
   Freise N, 2019, BLOOD, V134, P134, DOI 10.1182/blood.2019000320
   Gomes AC, 2018, GUT MICROBES, V9, P308, DOI 10.1080/19490976.2018.1465157
   Gu J, 2009, AM J GERIATR PHARMAC, V7, P26, DOI 10.1016/j.amjopharm.2009.02.005
   Guadagnini D, 2019, LIFE SCI, V234, DOI 10.1016/j.lfs.2019.116793
   Ham M, 2016, DIABETES, V65, P2624, DOI 10.2337/db16-0060
   Hernandez JB, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms8216
   Hirosumi J, 2002, NATURE, V420, P333, DOI 10.1038/nature01137
   Jalanka J, 2015, GUT, V64, P1562, DOI 10.1136/gutjnl-2014-307240
   Jiang XF, 2019, SCIENCE, V363, P181, DOI 10.1126/science.aau5238
   Jiao JZ, 2018, J AGR FOOD CHEM, V66, P1047, DOI 10.1021/acs.jafc.7b05297
   Kahn SE, 2006, NATURE, V444, P840, DOI 10.1038/nature05482
   King AJF, 2012, BRIT J PHARMACOL, V166, P877, DOI 10.1111/j.1476-5381.2012.01911.x
   KNEBEL B, 2017, INT J MOL SCI, V18, pNIL_1837, DOI DOI 10.3390/ijms18091928
   KOBASHI K, 1980, PLANTA MED, V40, P225, DOI 10.1055/s-2008-1074963
   Kopp A, 2010, ENDOCRINOLOGY, V151, P1097, DOI 10.1210/en.2009-1140
   Langille MGI, 2013, NAT BIOTECHNOL, V31, P814, DOI 10.1038/nbt.2676
   Lozupone CA, 2012, NATURE, V489, P220, DOI 10.1038/nature11550
   Malik EM, 2016, MED RES REV, V36, P705, DOI 10.1002/med.21391
   Martinerie C, 2016, DIABETES, V65, P2502, DOI 10.2337/db15-0617
   Milligan G, 2009, BRIT J PHARMACOL, V158, P146, DOI 10.1111/j.1476-5381.2009.00421.x
   Musso G, 2011, ANNU REV MED, V62, P361, DOI 10.1146/annurev-med-012510-175505
   Perry RJ, 2016, NATURE, V534, P213, DOI 10.1038/nature18309
   Planer JD, 2016, NATURE, V534, P263, DOI 10.1038/nature17940
   Plovier H, 2017, NAT MED, V23, P107, DOI 10.1038/nm.4236
   Puri P, 2018, HEPATOLOGY, V67, P1284, DOI 10.1002/hep.29623
   Ridaura VK, 2013, SCIENCE, V341, P1079, DOI 10.1126/science.1241214
   Roden M, 2019, NATURE, V576, P51, DOI 10.1038/s41586-019-1797-8
   Saito Toshiyuki, 2007, Diabetes, V56, pe21, DOI 10.2337/db07-1181
   Sangeetha KN, 2017, BIOINFORMATION, V13, P394, DOI 10.6026/97320630013394
   Sommer F, 2017, NAT REV MICROBIOL, V15, P630, DOI 10.1038/nrmicro.2017.58
   Sonnenburg JL, 2016, NATURE, V535, P56, DOI 10.1038/nature18846
   SU S, 2016, WORLD CHIN J DIGESTO, V24, P2720, DOI DOI 10.11569/wcjd.v24.i17.2720
   Van Gorkom BAP, 1999, ALIMENT PHARM THERAP, V13, P443
   Wang CY, 2012, METHODS MOL BIOL, V821, P421, DOI 10.1007/978-1-61779-430-8_27
   Wang J, 2010, PHYTOMEDICINE, V17, P684, DOI 10.1016/j.phymed.2009.10.009
   Wei XC, 2012, CELL HOST MICROBE, V11, P140, DOI 10.1016/j.chom.2011.12.006
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   XIAO PG, 1984, J ETHNOPHARMACOL, V10, P275, DOI 10.1016/0378-8741(84)90016-3
   Zheng C, 2016, CELL DEATH DIS, V7, DOI 10.1038/cddis.2016.54
NR 56
TC 14
Z9 15
U1 5
U2 14
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PD JUN 25
PY 2020
VL 2020
AR 2375676
DI 10.1155/2020/2375676
PG 16
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA MM2KO
UT WOS:000549986100001
PM 32685087
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Yu, LL
   Zhou, XT
   Duan, H
   Chen, Y
   Cui, SM
   Guo, RM
   Xue, YZ
   Tian, FW
   Zhao, JX
   Zhang, H
   Zhai, QX
   Chen, W
AF Yu, Leilei
   Zhou, Xingting
   Duan, Hui
   Chen, Ying
   Cui, Shumao
   Guo, Renmei
   Xue, Yuzheng
   Tian, Fengwei
   Zhao, Jianxin
   Zhang, Hao
   Zhai, Qixiao
   Chen, Wei
TI Synergistic Protective Effects of Different Dietary Supplements Against
   Type 2 Diabetes via Regulating Gut Microbiota
SO JOURNAL OF MEDICINAL FOOD
LA English
DT Article
DE gut microbiota; prebiotics; probiotics; synergistic effect; type 2
   diabetes
ID MULBERRY LEAF EXTRACT; CHITOSAN OLIGOSACCHARIDES; POSTPRANDIAL
   HYPERGLYCEMIA; GLUCOSE-HOMEOSTASIS; INSULIN SENSITIVITY;
   MOLECULAR-WEIGHT; LIVER-FUNCTION; FUCOIDAN; RATS; METABOLISM
AB Diabetes mellitus is a global health problem, and its prevalence continues to increase. Dietary supplements, including probiotics, prebiotics, and plant extracts, have been shown to alleviate diabetes. In this study, the synergistic effects of two types of dietary supplements were investigated in a mouse model of type 2 diabetes mellitus (T2DM). Sixty mice were divided into the following six groups: control, model (induced by a high-fat diet and intraperitoneal injection of streptozotocin), drug (metformin), probiotic (Lactobacillus spp.), formula A (probiotics, plant extracts, and soybean peptide), and formula B (probiotics, prebiotics, and soybean peptide). All three dietary interventions (probiotic, formula A, and formula B groups) significantly reduced the blood glucose level and oral glucose tolerance level and effectively improved some biochemical parameters (e.g., chronic inflammation, oxidative stress, and blood lipid level) and regulated gut microbiota. Notably, formula B exhibited a better ability on reducing the blood glucose level, regulating the gut microbiota, and increasing the short-chain fatty acid levels compared with the probiotics alone and formula A. Thus, formula B may exert synergistic protective effects against T2DM through a mechanism involving probiotics and prebiotics of gut microbiota regulation. This study provides a theoretical basis for the application of probiotic dietary supplements to the treatment of T2DM.
C1 [Yu, Leilei; Zhou, Xingting; Duan, Hui; Chen, Ying; Cui, Shumao; Tian, Fengwei; Zhao, Jianxin; Zhang, Hao; Zhai, Qixiao; Chen, Wei] Jiangnan Univ, State Key Lab Food Sci & Technol, Wuxi 214122, Jiangsu, Peoples R China.
   [Yu, Leilei; Zhou, Xingting; Duan, Hui; Chen, Ying; Cui, Shumao; Tian, Fengwei; Zhao, Jianxin; Zhang, Hao; Zhai, Qixiao; Chen, Wei] Jiangnan Univ, Sch Food Sci & Technol, Wuxi, Jiangsu, Peoples R China.
   [Zhao, Jianxin; Chen, Wei] Jiangnan Univ, Natl Engn Res Ctr Funct Food, Wuxi, Jiangsu, Peoples R China.
   [Yu, Leilei; Tian, Fengwei; Zhang, Hao; Zhai, Qixiao] Jiangnan Univ, Int Joint Res Lab Probiot, Wuxi, Jiangsu, Peoples R China.
   [Guo, Renmei] Suzhou Setek Biotechnol Ltd, Suzhou, Peoples R China.
   [Xue, Yuzheng] Jiangnan Univ, Affiliated Hosp, Dept Gastroenterol, Wuxi 214122, Jiangsu, Peoples R China.
   [Zhang, Hao] Jiangnan Univ, Yangzhou Inst Food Biotechnol, Yangzhou, Jiangsu, Peoples R China.
   [Chen, Wei] Beijing Technol & Business Univ, Beijing Innovat Ctr Food Nutr & Human Hlth, Beijing, Peoples R China.
C3 Jiangnan University; Jiangnan University; Jiangnan University; Jiangnan
   University; Jiangnan University; Jiangnan University; Beijing Technology
   & Business University
RP Chen, W (通讯作者)，Jiangnan Univ, State Key Lab Food Sci & Technol, Wuxi 214122, Jiangsu, Peoples R China.; Xue, YZ (通讯作者)，Jiangnan Univ, Affiliated Hosp, Dept Gastroenterol, Wuxi 214122, Jiangsu, Peoples R China.
EM xueyz001@163.com; chenwei66@jiangnan.edu.cn
RI Zhang, Hao/HHM-1940-2022; Chen, Wei/GZK-7348-2022
OI Xue, Yuzheng/0000-0003-1020-7059
CR Andreasen AS, 2010, BRIT J NUTR, V104, P1831, DOI 10.1017/S0007114510002874
   Chamberlain JJ, 2018, ANN INTERN MED, V168, P640, DOI 10.7326/M18-0222
   Chen P, 2014, J FUNCT FOODS, V10, P318, DOI 10.1016/j.jff.2014.06.014
   De Vadder F, 2014, CELL, V156, P84, DOI 10.1016/j.cell.2013.12.016
   Gao ZG, 2009, DIABETES, V58, P1509, DOI 10.2337/db08-1637
   Gilbert ER., 2014, EXP DIABETES RES, V2011
   Hsieh FC, 2013, NUTR METAB, V10, DOI 10.1186/1743-7075-10-35
   International Diabetes Federation (IDF), 2017, IDF DIAB ATL TEB
   Jangi S, 2016, NAT COMMUN, V7, DOI 10.1038/ncomms12015
   Jeszka-Skowron M, 2014, J FUNCT FOODS, V8, P9, DOI 10.1016/j.jff.2014.02.018
   Kim GN, 2011, J MED FOOD, V14, P712, DOI 10.1089/jmf.2010.1368
   Kim Kyung-Tae, 2015, PharmaNutrition, V3, P108, DOI 10.1016/j.phanu.2015.02.001
   Kim YA, 2018, NUTR RES REV, V31, P35, DOI 10.1017/S095442241700018X
   Kumar SG, 2009, PROTEOMICS, V9, P2149, DOI 10.1002/pmic.200800571
   Lee HW, 2003, BIOL PHARM BULL, V26, P1100
   Lenoir-Wijnkoop I, 2007, NUTR REV, V65, P469, DOI 10.1111/j.1753-4887.2007.tb00272.x
   Li XF, 2016, RSC ADV, V6, P63536, DOI 10.1039/c6ra10858j
   Lin HTV, 2017, MAR DRUGS, V15, DOI 10.3390/md15040113
   Lu JL, 2012, J NUTR BIOCHEM, V23, P1449, DOI 10.1016/j.jnutbio.2011.09.007
   Marazza JA, 2013, J FUNCT FOODS, V5, P1848, DOI 10.1016/j.jff.2013.09.005
   Martel J, 2017, NAT REV ENDOCRINOL, V13, P149, DOI 10.1038/nrendo.2016.142
   Martin R, 2016, FRONT MICROBIOL, V7, DOI 10.3389/fmicb.2016.00608
   Micheli L, 2019, NUTRIENTS, V11, DOI 10.3390/nu11081778
   Miyahara C, 2004, J NUTR SCI VITAMINOL, V50, P161, DOI 10.3177/jnsv.50.161
   Namaboot J, 2009, NUTR RES, V29, P602, DOI 10.1016/j.nutres.2009.06.002
   Neuenschwander M, 2019, BMJ-BRIT MED J, V366, DOI 10.1136/bmj.l2368
   Nikbakht E, 2018, EUR J NUTR, V57, P95, DOI 10.1007/s00394-016-1300-3
   Pan MF, 2016, J DAIRY SCI, V99, P970, DOI 10.3168/jds.2015-10510
   Pasupathi P, 2009, DIABETES METAB SYND, V3, P160, DOI 10.1016/j.dsx.2009.07.004
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Rahman I, 2006, BIOCHEM PHARMACOL, V72, P1439, DOI 10.1016/j.bcp.2006.07.004
   Remely M, 2016, ENDOCR METAB IMMUNE, V16, P99, DOI 10.2174/1871530316666160831093813
   Sakai T, 2013, J NUTR SCI VITAMINOL, V59, P144, DOI 10.3177/jnsv.59.144
   Sehra D, 2011, EXPERT OPIN DRUG SAF, V10, P851, DOI 10.1517/14740338.2011.583234
   Shah N., 2017, EMJ DIABETES, V5, P104, DOI [10.33590/emjdiabet/10310327, DOI 10.33590/EMJDIABET/10310327]
   Shakeri H, 2014, LIPIDS, V49, P695, DOI 10.1007/s11745-014-3901-z
   Shang QS, 2017, J FUNCT FOODS, V28, P138, DOI 10.1016/j.jff.2016.11.002
   Sircana A, 2018, CURR DIABETES REP, V18, DOI 10.1007/s11892-018-1057-6
   Spadafranca A, 2013, BRIT J NUTR, V109, P1789, DOI 10.1017/S0007114512003741
   Wang G, 2020, FOOD FUNCT, V11, P5898, DOI [10.1039/c9fo02761k, 10.1039/C9FO02761K]
   Wang J, 2014, MAR DRUGS, V12, P3292, DOI 10.3390/md12063292
   Wang YM, 2020, BIOMED PHARMACOTHER, V125, DOI 10.1016/j.biopha.2020.109914
   Wei Y, 2015, BMC INFECT DIS, V15, DOI 10.1186/s12879-015-0973-1
   Wu CT, 2018, REGUL TOXICOL PHARM, V92, P67, DOI 10.1016/j.yrtph.2017.11.008
   Xue ML, 2018, FOOD FUNCT, V9, P1214, DOI 10.1039/c7fo01677h
   Yoo JY, 2016, NUTRIENTS, V8, DOI 10.3390/nu8030173
   Yu LL, 2019, PEERJ, V7, DOI 10.7717/peerj.6963
   Zheng JP, 2018, CARBOHYD POLYM, V190, P77, DOI 10.1016/j.carbpol.2018.02.058
   Zheng JP, 2018, MAR DRUGS, V16, DOI 10.3390/md16020066
   Zhu KX, 2016, J AGR FOOD CHEM, V64, P1938, DOI 10.1021/acs.jafc.5b06103
NR 50
TC 6
Z9 6
U1 5
U2 33
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-620X
EI 1557-7600
J9 J MED FOOD
JI J. Med. Food
PD MAR 1
PY 2021
VL 24
IS 3
BP 319
EP 330
DI 10.1089/jmf.2020.4759
PG 12
WC Chemistry, Medicinal; Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Food Science & Technology; Nutrition &
   Dietetics
GA QZ2FX
UT WOS:000630549700013
PM 33739885
DA 2023-06-08
ER

PT J
AU Chiefari, E
   Mirabelli, M
   La Vignera, S
   Tanyolac, S
   Foti, DP
   Aversa, A
   Brunetti, A
AF Chiefari, Eusebio
   Mirabelli, Maria
   La Vignera, Sandro
   Tanyolac, Sinan
   Foti, Daniela Patrizia
   Aversa, Antonio
   Brunetti, Antonio
TI Insulin Resistance and Cancer: In Search for a Causal Link
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE insulin resistance; hyperglycemia; cancer; epigenetics; gut microbiota;
   metformin; PPAR gamma
ID LONG NONCODING RNA; GROWTH-FACTOR-II; HUMAN HEPATOCELLULAR-CARCINOMA;
   PI3K/AKT SIGNALING PATHWAY; ACTIVATED RECEPTOR-GAMMA; BODY-MASS INDEX;
   DIABETES-MELLITUS; BREAST-CANCER; PROSTATE-CANCER; BLADDER-CANCER
AB Insulin resistance (IR) is a condition which refers to individuals whose cells and tissues become insensitive to the peptide hormone, insulin. Over the recent years, a wealth of data has made it clear that a synergistic relationship exists between IR, type 2 diabetes mellitus, and cancer. Although the underlying mechanism(s) for this association remain unclear, it is well established that hyperinsulinemia, a hallmark of IR, may play a role in tumorigenesis. On the other hand, IR is strongly associated with visceral adiposity dysfunction and systemic inflammation, two conditions which favor the establishment of a pro-tumorigenic environment. Similarly, epigenetic modifications, such as DNA methylation, histone modifications, and non-coding RNA, in IR states, have been often associated with tumorigenesis in numerous types of human cancer. In addition to these observations, it is also broadly accepted that gut microbiota may play an intriguing role in the development of IR-related diseases, including type 2 diabetes and cancer, whereas potential chemopreventive properties have been attributed to some of the most commonly used antidiabetic medications. Herein we provide a concise overview of the most recent literature in this field and discuss how different but interrelated molecular pathways may impact on tumor development.</p>
C1 [Chiefari, Eusebio; Mirabelli, Maria; Brunetti, Antonio] Magna Graecia Univ Catanzaro, Dept Hlth Sci, I-88100 Catanzaro, Italy.
   [La Vignera, Sandro] Univ Catania, Dept Clin & Expt Med, I-95100 Catania, Italy.
   [Tanyolac, Sinan] Biruni Univ, Sch Med, Div Endocrinol & Metab, Dept Internal Med, TR-34010 Istanbul, Turkey.
   [Foti, Daniela Patrizia; Aversa, Antonio] Magna Graecia Univ Catanzaro, Dept Expt & Clin Med, I-88100 Catanzaro, Italy.
C3 Magna Graecia University of Catanzaro; University of Catania; Biruni
   University; Magna Graecia University of Catanzaro
RP Brunetti, A (通讯作者)，Magna Graecia Univ Catanzaro, Dept Hlth Sci, I-88100 Catanzaro, Italy.
EM maria.mirabelli@unicz.it; sandrolavignera@unict.it; stanyolac@gmail.com
RI Foti, Daniela P/K-8038-2016; Mirabelli, Maria/AAO-4757-2021; Tanyolac,
   Sinan/AAP-5966-2021
OI Foti, Daniela P/0000-0002-9536-5736; Tanyolac,
   Sinan/0000-0003-4238-5132; Aversa, Antonio/0000-0002-2989-2618;
   Mirabelli, Maria/0000-0002-6427-7186; Brunetti,
   Antonio/0000-0003-1533-8779; La Vignera, Sandro/0000-0002-7113-2372
FU European Commission; FESR FSE 2014-2020; Regione Calabria
FX This publication is co-financed with the support of the European
   Commission, FESR FSE 2014-2020 and Regione Calabria. The European
   Commission and Regione Calabria's support for the production of this
   publication do not constitute an endorsement of the contents, which
   reflect the views of the authors only, and cannot be held responsible
   for any use that may be made of the information contained therein.
CR Adami HO, 1996, J NATL CANCER I, V88, P1472, DOI 10.1093/jnci/88.20.1472
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Alessi DR, 1997, CURR BIOL, V7, P261, DOI 10.1016/S0960-9822(06)00122-9
   Alwahsh S. M., 2015, Journal of Obesity & Weight Loss Therapy, V5, P280
   Alwahsh SM, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18020285
   Amer Diabet Assoc, 2020, DIABETES CARE, V43, pS98, DOI 10.2337/dc20-S009
   American Diabetes Association, 2004, Diabetes Care, V27 Suppl 1, pS5, DOI 10.2337/diacare.27.2007.S5
   ARAKI E, 1987, J BIOL CHEM, V262, P16186
   Arcidiacono B, 2020, EBIOMEDICINE, V59, DOI 10.1016/j.ebiom.2020.102912
   Arcidiacono B, 2015, FRONT ENDOCRINOL, V5, DOI 10.3389/fendo.2014.00237
   Arcidiacono B, 2012, EXP DIABETES RES, DOI 10.1155/2012/789174
   Arkan MC, 2005, NAT MED, V11, P191, DOI 10.1038/nm1185
   Arnoldo L, 2015, SCI REP-UK, V5, DOI 10.1038/srep08552
   Audia JE, 2016, CSH PERSPECT BIOL, V8, DOI 10.1101/cshperspect.a019521
   Baker JM, 2017, MATURITAS, V103, P45, DOI 10.1016/j.maturitas.2017.06.025
   Baldeon RL, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0129421
   Balkau B, 2001, DIABETES CARE, V24, P843, DOI 10.2337/diacare.24.5.843
   Bansal D, 2013, PROSTATE CANCER P D, V16, P151, DOI 10.1038/pcan.2012.40
   Bao CP, 2013, J DIABETES COMPLICAT, V27, P357, DOI 10.1016/j.jdiacomp.2013.01.004
   Baran-Gale J, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0073240
   Barbieri I, 2010, CANCER RES, V70, P2558, DOI 10.1158/0008-5472.CAN-09-2840
   Belfiore A, 2009, ENDOCR REV, V30, P586, DOI 10.1210/er.2008-0047
   Ben QW, 2011, EUR J CANCER, V47, P1928, DOI 10.1016/j.ejca.2011.03.003
   Birts CN, 2020, SCI SIGNAL, V13, DOI 10.1126/scisignal.aau9529
   Blair CK, 2019, NPJ BREAST CANCER, V5, DOI 10.1038/s41523-019-0128-4
   Boucher J, 2014, CSH PERSPECT BIOL, V6, DOI 10.1101/cshperspect.a009191
   Bowers LW, 2018, MOL CANCER RES, V16, P869, DOI 10.1158/1541-7786.MCR-17-0508
   Bowers LW, 2015, FRONT ENDOCRINOL, V6, DOI 10.3389/fendo.2015.00077
   BRISIGOTTI M, 1993, PEDIATR PATHOL, V13, P549
   Broadbent HM, 2008, HUM MOL GENET, V17, P806, DOI 10.1093/hmg/ddm352
   Brunetti A, 2001, FASEB J, V15, P492, DOI 10.1096/fj.00-0190com
   BRUNETTI A, 1993, J CLIN INVEST, V92, P1288, DOI 10.1172/JCI116702
   Brunetti A, 2014, WORLD J DIABETES, V5, P128, DOI 10.4239/wjd.v5.i2.128
   Bulger DA, 2015, BIOCHEM BIOPH RES CO, V461, P533, DOI 10.1016/j.bbrc.2015.04.063
   Bullo M, 2002, INT J OBESITY, V26, P652, DOI 10.1038/sj.ijo.0801977
   Cai HZ, 2015, DIABETES-METAB RES, V31, P336, DOI 10.1002/dmrr.2582
   Cairns RA, 2011, NAT REV CANCER, V11, P85, DOI 10.1038/nrc2981
   Calle EE, 2003, NEW ENGL J MED, V348, P1625, DOI 10.1056/NEJMoa021423
   Campagnoli C, 2013, CLIN BREAST CANCER, V13, P433, DOI 10.1016/j.clbc.2013.08.012
   Cao X, 2017, JNCI CANCER SPECT, V1, DOI 10.1093/jncics/pkx007
   Carreras-Torres R, 2017, JNCI-J NATL CANCER I, V109, DOI 10.1093/jnci/djx012
   Carstensen B, 2012, DIABETOLOGIA, V55, P948, DOI 10.1007/s00125-011-2381-4
   Carstensen B, 2016, DIABETOLOGIA, V59, P980, DOI 10.1007/s00125-016-3884-9
   Carter G, 2015, BBA CLIN, V4, P102, DOI 10.1016/j.bbacli.2015.09.001
   Castillo JJ, 2012, BLOOD, V119, P4845, DOI 10.1182/blood-2011-06-362830
   Catsburg C, 2014, CANCER RES, V74, P3248, DOI 10.1158/0008-5472.CAN-13-3514
   Chan JL, 2003, J CLIN INVEST, V111, P1409, DOI 10.1172/JCI200317490
   Chang CH, 2012, J CLIN ENDOCR METAB, V97, pE1170, DOI 10.1210/jc.2012-1162
   Chen BQ, 2019, CELLS-BASEL, V8, DOI 10.3390/cells8121638
   Chen HY, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-41053-z
   Chen S, 2017, MEDICINE, V96, DOI 10.1097/MD.0000000000007981
   Chen YZ, 2017, BMC PUBLIC HEALTH, V17, DOI 10.1186/s12889-017-4953-9
   Chen Y, 2011, CANCER PREV RES, V4, P76, DOI 10.1158/1940-6207.CAPR-10-0167
   Chettouh H, 2013, CANCER RES, V73, P3974, DOI 10.1158/0008-5472.CAN-12-3824
   Chiefari E, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00357
   Chiefari E, 2013, SCI REP-UK, V3, DOI 10.1038/srep01491
   Chiefari E, 2012, SCI REP-UK, V2, DOI 10.1038/srep00251
   Chiefari E, 2011, JAMA-J AM MED ASSOC, V305, P903, DOI 10.1001/jama.2011.207
   Chiefari E, 2010, NAT COMMUN, V1, DOI 10.1038/ncomms1040
   Chistiakov DA, 2015, BIOMED RES INT, V2015, DOI 10.1155/2015/354517
   Chlebowski RT, 2012, J CLIN ONCOL, V30, P2844, DOI 10.1200/JCO.2011.39.7505
   Chu DX, 2018, BMC CANCER, V18, DOI 10.1186/s12885-018-4334-5
   Cignarelli A, 2018, DIABETES RES CLIN PR, V143, P378, DOI 10.1016/j.diabres.2018.04.002
   Cochrane Dawn R., 2010, Hormones & Cancer, V1, P306, DOI 10.1007/s12672-010-0043-5
   Colin-Cassin C, 2015, MOL CARCINOGEN, V54, P393, DOI 10.1002/mc.22109
   Corigliano DM, 2018, PEERJ, V6, DOI 10.7717/peerj.5386
   Costa V, 2008, ENDOCR-RELAT CANCER, V15, P325, DOI 10.1677/ERC-07-0226
   Crujeiras AB, 2015, HUM REPROD UPDATE, V21, P249, DOI 10.1093/humupd/dmu060
   Curat CA, 2004, DIABETES, V53, P1285, DOI 10.2337/diabetes.53.5.1285
   Currie CJ, 2009, DIABETOLOGIA, V52, P1766, DOI 10.1007/s00125-009-1440-6
   D'Esposito V, 2020, FRONT ONCOL, V10, DOI 10.3389/fonc.2020.01554
   D'Ignazio L, 2016, FEBS J, V283, P413, DOI 10.1111/febs.13578
   DeFronzo RA, 2009, DIABETES, V58, P773, DOI 10.2337/db09-9028
   Deiuliis JA, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0165962
   den Besten G, 2013, J LIPID RES, V54, P2325, DOI 10.1194/jlr.R036012
   Denley A, 2004, MOL ENDOCRINOL, V18, P2502, DOI 10.1210/me.2004-0183
   Di Martino MT, 2016, EXPERT OPIN THER TAR, V20, P1099, DOI 10.1517/14728222.2016.1164693
   Dibble CC, 2015, TRENDS CELL BIOL, V25, P545, DOI 10.1016/j.tcb.2015.06.002
   Dizaji BF, 2018, DIABETES METAB SYND, V12, P783, DOI 10.1016/j.dsx.2018.04.009
   Du R, 2018, DIABETES-METAB RES, V34, DOI 10.1002/dmrr.2961
   EBINA Y, 1985, P NATL ACAD SCI USA, V82, P8014, DOI 10.1073/pnas.82.23.8014
   Egger G, 2004, NATURE, V429, P457, DOI 10.1038/nature02625
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Fabbri M, 2008, LEUKEMIA, V22, P1095, DOI 10.1038/leu.2008.30
   Fernandes J, 2014, NUTR DIABETES, V4, DOI 10.1038/nutd.2014.23
   Fornari F, 2010, CANCER RES, V70, P5184, DOI 10.1158/0008-5472.CAN-10-0145
   Foti D, 2005, NAT MED, V11, P765, DOI 10.1038/nm1254
   Foti D, 2003, MOL CELL BIOL, V23, P2720, DOI 10.1128/MCB.23.8.2720-2732.2003
   Foti DP, 2017, FRONT ENDOCRINOL, V8, DOI 10.3389/fendo.2017.00034
   Frasca F, 1999, MOL CELL BIOL, V19, P3278, DOI 10.1128/mcb.19.5.3278
   Frost RJA, 2011, P NATL ACAD SCI USA, V108, P21075, DOI 10.1073/pnas.1118922109
   Fruman DA, 2017, CELL, V170, P605, DOI 10.1016/j.cell.2017.07.029
   Fruman DA, 2014, NAT REV DRUG DISCOV, V13, P140, DOI 10.1038/nrd4204
   Gallagher EJ, 2020, NAT REV CANCER, V20, P629, DOI 10.1038/s41568-020-0295-5
   Gao ZJ, 2018, PATHOL RES PRACT, V214, P700, DOI 10.1016/j.prp.2018.03.013
   Ge ZM, 2011, EUR J GASTROEN HEPAT, V23, P1127, DOI 10.1097/MEG.0b013e32834b8d73
   GIARDINO I, 1994, J CLIN INVEST, V94, P110, DOI 10.1172/JCI117296
   Giovannucci E, 2010, DIABETES CARE, V33, P1674, DOI 10.2337/dc10-0666
   GOLDFINE ID, 1973, BIOCHEM BIOPH RES CO, V53, P852, DOI 10.1016/0006-291X(73)90171-X
   Gong TT, 2019, FRONT ONCOL, V9, DOI 10.3389/fonc.2019.00458
   Gonullu G, 2005, CYTOKINE, V31, P264, DOI 10.1016/j.cyto.2005.05.003
   Goodwin PJ, 2015, ANNU REV MED, V66, P281, DOI 10.1146/annurev-med-051613-012328
   Greco AV, 2002, DIABETES, V51, P144, DOI 10.2337/diabetes.51.1.144
   Greco M, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.00528
   Greco M, 2014, MEDIAT INFLAMM, V2014, DOI 10.1155/2014/750860
   Grillier-Vuissoz I., 2012, J CARCINOGENE MUTAGE, VS8, DOI DOI 10.4172/2157-2518.S8-002
   Grossmann ME, 2008, BRIT J CANCER, V98, P370, DOI 10.1038/sj.bjc.6604166
   HAMMES HP, 1991, P NATL ACAD SCI USA, V88, P11555, DOI 10.1073/pnas.88.24.11555
   HAWKINS PT, 1992, NATURE, V358, P157, DOI 10.1038/358157a0
   He AB, 2007, MOL ENDOCRINOL, V21, P2785, DOI 10.1210/me.2007-0167
   He KC, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-018-38285-w
   Heckman-Stoddard BM, 2017, DIABETOLOGIA, V60, P1639, DOI 10.1007/s00125-017-4372-6
   Heianza Y, 2019, GUT, V68, P263, DOI 10.1136/gutjnl-2018-316155
   Heiden MGV, 2009, SCIENCE, V324, P1029, DOI 10.1126/science.1160809
   Hensley CT, 2016, CELL, V164, P681, DOI 10.1016/j.cell.2015.12.034
   Hidaka A, 2015, INT J CANCER, V136, P1402, DOI 10.1002/ijc.29098
   Hirosumi J, 2002, NATURE, V420, P333, DOI 10.1038/nature01137
   Howe EN, 2012, J MAMMARY GLAND BIOL, V17, P65, DOI 10.1007/s10911-012-9244-6
   Hu J, 2018, MEDICINE, V97, DOI 10.1097/MD.0000000000011596
   Hu YQ, 2015, PANCREAS, V44, P342, DOI 10.1097/MPA.0000000000000274
   Huang XP, 2015, FEBS J, V282, P579, DOI 10.1111/febs.13167
   Iiritano S, 2012, MOL ENDOCRINOL, V26, P1578, DOI 10.1210/me.2011-1379
   Iliopoulos D, 2009, SCI SIGNAL, V2, DOI 10.1126/scisignal.2000356
   Irwin ML, 2011, J CLIN ONCOL, V29, P47, DOI 10.1200/JCO.2010.28.4752
   Ishikawa M, 2004, CLIN CANCER RES, V10, P4325, DOI 10.1158/1078-0432.CCR-03-0749
   Ji P, 2003, ONCOGENE, V22, P8031, DOI 10.1038/sj.onc.1206928
   Jiang Min, 2018, Oncotarget, V9, P13948, DOI 10.18632/oncotarget.24189
   Jiang Y, 2011, EUR J EPIDEMIOL, V26, P863, DOI 10.1007/s10654-011-9617-y
   Jing W, 2012, EUR J CANCER PREV, V21, P24, DOI 10.1097/CEJ.0b013e3283481d89
   Jones PA, 2007, CELL, V128, P683, DOI 10.1016/j.cell.2007.01.029
   Jordan SD, 2011, NAT CELL BIOL, V13, P434, DOI 10.1038/ncb2211
   Josse C, 2014, AM J PHYSIOL-GASTR L, V306, pG229, DOI 10.1152/ajpgi.00484.2012
   Jung SY, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0218917
   Kalyanaraman B, 2017, REDOX BIOL, V12, P833, DOI 10.1016/j.redox.2017.04.018
   Kang CF, 2018, ENDOCRINOLOGY, V159, P3801, DOI 10.1210/en.2018-00574
   Kang LH, 2015, EUR J CANCER, V51, P260, DOI 10.1016/j.ejca.2014.10.031
   Kershaw EE, 2004, J CLIN ENDOCR METAB, V89, P2548, DOI 10.1210/jc.2004-0395
   Kim YS, 2020, NUTR METAB CARDIOVAS, V30, P1714, DOI 10.1016/j.numecd.2020.05.010
   KOLTERMAN OG, 1980, J CLIN INVEST, V65, P1272, DOI 10.1172/JCI109790
   Kong LH, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0188029
   Kong YH, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00405
   Kwa M, 2016, JNCI-J NATL CANCER I, V108, DOI 10.1093/jnci/djw029
   Kwak SH, 2016, EXP MOL MED, V48, DOI 10.1038/emm.2016.7
   Kwon JJ, 2019, MOL THER-ONCOLYTICS, V12, P173, DOI 10.1016/j.omto.2018.12.011
   Lang HM, 2018, CELL PHYSIOL BIOCHEM, V48, P185, DOI 10.1159/000491717
   Laria AE, 2018, PROTEOMICS, V18, DOI [10.1002/pmic.201700260, 10.1002/pmic.2]
   Larsson SC, 2007, INT J CANCER, V121, P856, DOI 10.1002/ijc.22717
   Le Chatelier E, 2013, NATURE, V500, P541, DOI 10.1038/nature12506
   Lee CJ, 2020, ANN NY ACAD SCI, V1461, P37, DOI 10.1111/nyas.14107
   Lee JO, 2016, SCI REP-UK, V6, DOI 10.1038/srep18923
   Lee JY, 2013, EUR J CANCER, V49, P2411, DOI 10.1016/j.ejca.2013.02.025
   Lee JY, 2013, INT J GYNECOL CANCER, V23, P402, DOI 10.1097/IGC.0b013e31828189b2
   Li JC, 2016, ANN THORAC SURG, V102, P829, DOI 10.1016/j.athoracsur.2016.02.016
   Li M, 2018, EUR REV MED PHARMACO, V22, P7883, DOI 10.26355/eurrev_201811_16414
   Li WX, 2008, INT J CANCER, V123, P1616, DOI 10.1002/ijc.23693
   Lien EC, 2016, RECENT RESULTS CANC, V207, P39, DOI 10.1007/978-3-319-42118-6_3
   Ling C, 2019, CELL METAB, V29, P1028, DOI 10.1016/j.cmet.2019.03.009
   Ling SB, 2014, MOL MED REP, V10, P2891, DOI 10.3892/mmr.2014.2614
   Ling SP, 2020, DIABETES CARE, V43, P2313, DOI 10.2337/dc20-0204
   Liu DD, 2018, AM J TRANSL RES, V10, P744
   Liu JY, 2014, CELL DEATH DIS, V5, DOI 10.1038/cddis.2014.466
   Liu PH, 2019, JAMA ONCOL, V5, P37, DOI 10.1001/jamaoncol.2018.4280
   Liu QL, 2018, CLIN CANCER RES, V24, P5622, DOI 10.1158/1078-0432.CCR-18-0420
   Loftfield E, 2016, CANCER PREV RES, V9, P866, DOI 10.1158/1940-6207.CAPR-16-0141
   Lu YY, 2016, SCI REP-UK, V6, DOI 10.1038/srep37589
   Lu YX, 2016, EPIDEMIOLOGY, V27, P423, DOI 10.1097/EDE.0000000000000447
   Luo M, 2013, SURGERY, V153, P836, DOI 10.1016/j.surg.2012.12.004
   Luo XF, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.639016
   Ma W, 2017, EXP THER MED, V14, P2853, DOI 10.3892/etm.2017.4847
   Malaguarnera R, 2012, ENDOCRINOLOGY, V153, P2152, DOI 10.1210/en.2011-1843
   MAMULA PW, 1990, DIABETES CARE, V13, P288, DOI 10.2337/diacare.13.3.288
   Manning BD, 2007, CELL, V129, P1261, DOI 10.1016/j.cell.2007.06.009
   Mari A, 2006, DIABETOLOGIA, V49, P2136, DOI 10.1007/s00125-006-0337-x
   Mari E, 2016, ONCOL LETT, V12, P2133, DOI 10.3892/ol.2016.4876
   Mark M, 2019, CLIN GENITOURIN CANC, V17, pE323, DOI 10.1016/j.clgc.2018.12.009
   Martello G, 2010, CELL, V141, P1195, DOI 10.1016/j.cell.2010.05.017
   Martini M, 2014, ANN MED, V46, P372, DOI 10.3109/07853890.2014.912836
   Matsha Tandi E, 2018, Oncotarget, V9, P30485, DOI 10.18632/oncotarget.25271
   Meerson A, 2013, DIABETOLOGIA, V56, P1971, DOI 10.1007/s00125-013-2950-9
   Mendoza MC, 2011, TRENDS BIOCHEM SCI, V36, P320, DOI 10.1016/j.tibs.2011.03.006
   Messineo S, 2017, DIABETOLOGIA, V60, pS564
   Messineo S, 2016, FRONT ENDOCRINOL, V7, DOI 10.3389/fendo.2016.00073
   Miao F, 2007, J BIOL CHEM, V282, P13854, DOI 10.1074/jbc.M609446200
   Duong MN, 2015, BREAST CANCER RES, V17, DOI 10.1186/s13058-015-0569-0
   Mirabelli M, 2021, J CLIN MED, V10, DOI 10.3390/jcm10050985
   Mirabelli M, 2020, NUTRIENTS, V12, DOI 10.3390/nu12041066
   Molenaar RJ, 2019, BMC CANCER, V19, DOI 10.1186/s12885-019-6346-1
   Monami M, 2014, ACTA DIABETOL, V51, P91, DOI 10.1007/s00592-013-0504-8
   MOSTHAF L, 1990, EMBO J, V9, P2409, DOI 10.1002/j.1460-2075.1990.tb07416.x
   Mourtada-Maarabouni M, 2009, ONCOGENE, V28, P195, DOI 10.1038/onc.2008.373
   Murphy TK, 2000, AM J EPIDEMIOL, V152, P847, DOI 10.1093/aje/152.9.847
   Nagaraja AK, 2010, MOL ENDOCRINOL, V24, P447, DOI 10.1210/me.2009-0295
   Naimo GD, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.00066
   Nam GE, 2020, CANCERS, V12, DOI 10.3390/cancers12061368
   Nayan M, 2015, UROL ONCOL-SEMIN ORI, V33, DOI 10.1016/j.urolonc.2015.05.024
   Nead KT, 2015, JNCI-J NATL CANCER I, V107, DOI 10.1093/jnci/djv178
   Noto H, 2011, ENDOCR PRACT, V17, P616, DOI 10.4158/EP10357.RA
   Orgel E, 2013, CURR DIABETES REP, V13, P213, DOI 10.1007/s11892-012-0356-6
   Orouji E, 2018, CLIN EPIGENETICS, V10, DOI 10.1186/s13148-018-0583-z
   OSBORNE CK, 1976, P NATL ACAD SCI USA, V73, P4536, DOI 10.1073/pnas.73.12.4536
   Pal A, 2012, NEW ENGL J MED, V367, P1002, DOI 10.1056/NEJMoa1113966
   Palakurthi SS, 2001, CANCER RES, V61, P6213
   Pan K, 2020, JNCI-J NATL CANCER I, V112, P170, DOI 10.1093/jnci/djz069
   Pandini G, 2003, J BIOL CHEM, V278, P42178, DOI 10.1074/jbc.M304980200
   Paneni F, 2015, CIRC-CARDIOVASC GENE, V8, P150, DOI 10.1161/CIRCGENETICS.114.000671
   Paonessa F, 2006, CANCER RES, V66, P5085, DOI 10.1158/0008-5472.CAN-05-3678
   Parida S, 2021, CANCER RES, V81, P790, DOI 10.1158/0008-5472.CAN-20-2629
   Pearson-Stuttard J, 2021, LANCET DIABETES ENDO, V9, P165, DOI 10.1016/S2213-8587(20)30431-9
   Pedroso JAB, 2019, HORM-INT J ENDOCRINO, V18, P127, DOI 10.1007/s42000-018-0078-5
   Pei YF, 2016, BBA-MOL BASIS DIS, V1862, P2177, DOI 10.1016/j.bbadis.2016.08.014
   Peng M, 2016, ONCOTARGET, V7, P9102, DOI 10.18632/oncotarget.6933
   Peng Y, 2013, P NATL ACAD SCI USA, V110, P15043, DOI 10.1073/pnas.1307107110
   Perez LM, 2013, DIABETES, V62, P2368, DOI 10.2337/db12-1220
   Pfalzer AC, 2018, CANCER EPIDEM BIOMAR, V27, P1416, DOI 10.1158/1055-9965.EPI-18-0121
   Pian LL, 2018, MOL THER-NUCL ACIDS, V12, P105, DOI 10.1016/j.omtn.2018.04.013
   Piccinni C, 2011, DIABETES CARE, V34, P1369, DOI 10.2337/dc10-2412
   Pischon T, 2006, J NATL CANCER I, V98, P920, DOI 10.1093/jnci/djj246
   Polak P, 2009, CURR OPIN CELL BIOL, V21, P209, DOI 10.1016/j.ceb.2009.01.024
   Poloz Y, 2015, CELL DEATH DIS, V6, DOI 10.1038/cddis.2015.381
   Ramos-Lopez O, 2018, MOL GENET METAB, V123, P50, DOI 10.1016/j.ymgme.2017.11.011
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Rector RS, 2007, AM J PHYSIOL-ENDOC M, V293, pE500, DOI 10.1152/ajpendo.00116.2007
   Ren HB, 2011, CANCER CAUSE CONTROL, V22, P837, DOI 10.1007/s10552-011-9754-3
   Renehan AG, 2004, LANCET, V363, P1346, DOI 10.1016/S0140-6736(04)16044-3
   Renehan AG, 2008, LANCET, V371, P569, DOI 10.1016/S0140-6736(08)60269-X
   Robinson N, 2021, CLIN EPIGENETICS, V13, DOI 10.1186/s13148-020-00952-z
   Rose DP, 2012, ENDOCR-RELAT CANCER, V19, pR225, DOI 10.1530/ERC-12-0203
   Rottiers V, 2012, NAT REV MOL CELL BIO, V13, P239, DOI 10.1038/nrm3313
   Rowland IR, 1999, MEDICAL IMPORTANCE OF THE NORMAL MICROFLORA, P295
   Rui LY, 2002, J BIOL CHEM, V277, P42394, DOI 10.1074/jbc.C200444200
   Rybinska I, 2020, CELLS-BASEL, V9, DOI 10.3390/cells9030560
   Samuel SM, 2019, BIOMOLECULES, V9, DOI 10.3390/biom9120846
   Sarbassov DD, 2005, SCIENCE, V307, P1098, DOI 10.1126/science.1106148
   Sartipy P, 2003, P NATL ACAD SCI USA, V100, P7265, DOI 10.1073/pnas.1133870100
   Sathishkumar C, 2018, HUM GENOMICS, V12, DOI 10.1186/s40246-018-0173-3
   Scharf JG, 2000, LAB INVEST, V80, P1399, DOI 10.1038/labinvest.3780147
   Schenk S, 2009, J PHYSIOL-LONDON, V587, P4949, DOI 10.1113/jphysiol.2009.175489
   Schiel R, 2005, EUR J MED RES, V10, P339
   Schmid D, 2013, EUR J EPIDEMIOL, V28, P945, DOI 10.1007/s10654-013-9865-0
   Schmidt M, 2002, MOL CELL BIOL, V22, P7842, DOI 10.1128/MCB.22.22.7842-7852.2002
   Sciacca L, 1999, ONCOGENE, V18, P2471, DOI 10.1038/sj.onc.1202600
   Sciacca L, 2003, ENDOCRINOLOGY, V144, P2650, DOI 10.1210/en.2002-0136
   SEINO S, 1989, P NATL ACAD SCI USA, V86, P114, DOI 10.1073/pnas.86.1.114
   Semenza GL, 2007, BIOCHEM J, V405, P1, DOI 10.1042/BJ20070389
   Semenza GL, 2012, TRENDS PHARMACOL SCI, V33, P207, DOI 10.1016/j.tips.2012.01.005
   Semple RK, 2011, ENDOCR REV, V32, P498, DOI 10.1210/er.2010-0020
   Sgarra R, 2018, BBA-REV CANCER, V1869, P216, DOI 10.1016/j.bbcan.2018.03.001
   Sharma M, 2020, FRONT GENET, V10, DOI 10.3389/fgene.2019.01329
   Sherwood L., 2013, PRESCOTTS MICROBIOLO
   Shi XF, 2015, MOL CARCINOGEN, V54, pE1, DOI 10.1002/mc.22120
   Shuai Y, 2020, CLIN TRANSL ONCOL, V22, P1580, DOI 10.1007/s12094-020-02304-y
   Slusarz A, 2015, J CARDIOVASC MED, V16, P480, DOI 10.2459/JCM.0000000000000246
   Solinas G, 2007, CELL METAB, V6, P386, DOI 10.1016/j.cmet.2007.09.011
   SOLL AH, 1975, J BIOL CHEM, V250, P4702
   Sona MF, 2018, JPN J CLIN ONCOL, V48, P426, DOI 10.1093/jjco/hyy047
   Stark JR, 2009, INT J CANCER, V124, P2683, DOI 10.1002/ijc.24241
   Statello L, 2021, NAT REV MOL CELL BIO, V22, P96, DOI 10.1038/s41580-020-00315-9
   Stocks T, 2009, PLOS MED, V6, DOI 10.1371/journal.pmed.1000201
   Stone TW, 2018, EBIOMEDICINE, V30, P14, DOI 10.1016/j.ebiom.2018.02.022
   Sun HY, 2015, HEPATOL RES, V45, P1312, DOI 10.1111/hepr.12500
   Sun JN, 2014, NUCLEIC ACIDS RES, V42, P9588, DOI 10.1093/nar/gku549
   SUN XJ, 1995, NATURE, V377, P173, DOI 10.1038/377173a0
   SUN XJ, 1991, NATURE, V352, P73, DOI 10.1038/352073a0
   Taliaferro-Smith L, 2009, ONCOGENE, V28, P2621, DOI 10.1038/onc.2009.129
   Taliaferro-Smith L, 2013, NEOPLASIA, V15, P23, DOI 10.1593/neo.121502
   Tarver T, 2012, J CONS HLTH INTERNET, V16, P366, DOI 10.1080/15398285.2012.701177
   Thomas T, 2000, METABOLISM, V49, P1278, DOI 10.1053/meta.2000.9519
   Tian T, 2012, EXP CLIN ENDOCR DIAB, V120, P217, DOI 10.1055/s-0031-1297969
   Trajkovski M, 2011, NATURE, V474, P649, DOI 10.1038/nature10112
   Trayhurn P, 2015, FRONT ENDOCRINOL, V6, DOI 10.3389/fendo.2015.00019
   Tseng CH, 2015, BMC CANCER, V15, DOI 10.1186/s12885-015-1876-7
   Tseng CH, 2012, DIABETES CARE, V35, P278, DOI 10.2337/dc11-1449
   Tsilidis KK, 2015, BMJ-BRIT MED J, V350, DOI 10.1136/bmj.g7607
   Tsujimoto T, 2017, INT J CANCER, V141, P102, DOI 10.1002/ijc.30729
   Tuccori M, 2016, BMJ-BRIT MED J, V352, DOI 10.1136/bmj.i1541
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   ULLRICH A, 1985, NATURE, V313, P756, DOI 10.1038/313756a0
   Unger RH, 2003, TRENDS ENDOCRIN MET, V14, P398, DOI 10.1016/j.tem.2003.09.008
   Uysal KT, 1997, NATURE, V389, P610, DOI 10.1038/39335
   Vancura A, 2018, TRENDS PHARMACOL SCI, V39, P867, DOI 10.1016/j.tips.2018.07.006
   Vigneri R, 2020, TRENDS ENDOCRIN MET, V31, P551, DOI 10.1016/j.tem.2020.05.004
   Viollet B, 2012, CLIN SCI, V122, P253, DOI 10.1042/CS20110386
   Vivacqua A, 2017, CURR PHARM DESIGN, V23, P3658, DOI 10.2174/1381612823666170622105123
   VOGT B, 1991, BIOCHEM BIOPH RES CO, V177, P1013, DOI 10.1016/0006-291X(91)90639-O
   Vozarova B, 2001, OBES RES, V9, P414, DOI 10.1038/oby.2001.54
   Vrieze A, 2012, GASTROENTEROLOGY, V143, P913, DOI 10.1053/j.gastro.2012.06.031
   Walaszczyk E, 2018, DIABETOLOGIA, V61, P354, DOI 10.1007/s00125-017-4497-7
   Wallach JD, 2020, BMJ-BRIT MED J, V368, DOI 10.1136/bmj.l7078
   Wang CH, 2018, ONCOGENE, V37, P589, DOI 10.1038/onc.2017.357
   Wang J, 2014, ONCOGENE, V33, P1181, DOI 10.1038/onc.2013.42
   Wang LH, 2017, MEDICINE, V96, DOI 10.1097/MD.0000000000006396
   Wang QA, 2018, CELL METAB, V28, P282, DOI 10.1016/j.cmet.2018.05.022
   Wang YM, 2012, GYNECOL ONCOL, V125, P734, DOI 10.1016/j.ygyno.2012.03.012
   Wang YZ, 2020, INT J COLORECTAL DIS, V35, P827, DOI 10.1007/s00384-020-03539-5
   Weber DR, 2014, J PEDIATR ENDOCR MET, V27, P1237, DOI 10.1515/jpem-2013-0402
   Wen Q, 2019, EUR J OBSTET GYN R B, V237, P33, DOI 10.1016/j.ejogrb.2019.03.029
   Whitt J, 2018, GASTROENTEROLOGY, V155, P501, DOI 10.1053/j.gastro.2018.04.017
   WHO, HLTH TOP DIAB
   World Cancer Research Fund. American Institute for Cancer Research, BOD FATN WEIGHT GAIN
   World Health Organization (WHO), 2020, OB OV FACT SHEET
   Wu Q, 2019, J HEMATOL ONCOL, V12, DOI 10.1186/s13045-019-0778-6
   Xiao K, 2020, J CLIN PHARM THER, V45, P783, DOI 10.1111/jcpt.13167
   Xie YQ, 2016, ONCOL LETT, V12, P375, DOI 10.3892/ol.2016.4636
   Xin WX, 2018, MOL CLIN ONCOL, V8, P483, DOI 10.3892/mco.2017.1541
   Xu H, 2015, ONCOLOGIST, V20, P1236, DOI 10.1634/theoncologist.2015-0096
   Xu HY, 2003, J CLIN INVEST, V112, P1821, DOI 10.1172/JCI200319451
   Xu YJ, 2017, ONCOL LETT, V14, P6379, DOI 10.3892/ol.2017.7033
   Yakar S., 2005, NOVARTIS FDN S, V262, P288
   YAMAGUCHI Y, 1991, ENDOCRINOLOGY, V129, P2058, DOI 10.1210/endo-129-4-2058
   Yamaguchi Y, 2016, DIGESTION, V94, P66, DOI 10.1159/000447690
   Yan CF, 2018, CELL DEATH DIS, V9, DOI 10.1038/s41419-018-0321-7
   Yao L, 2019, DIS MARKERS, V2019, DOI 10.1155/2019/6230162
   Yoon MS, 2017, FRONT PHYSIOL, V8, DOI 10.3389/fphys.2017.00788
   Yoshihara H, 2012, BIOCHEM BIOPH RES CO, V423, P122, DOI 10.1016/j.bbrc.2012.05.093
   You D, 2017, ELIFE, V6, DOI 10.7554/eLife.30766
   Yu H, 2003, CANCER EPIDEM BIOMAR, V12, P1067
   Yu HL, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0116327
   Yu H, 2014, NAT REV CANCER, V14, P736, DOI 10.1038/nrc3818
   Yu H, 2009, NAT REV CANCER, V9, P798, DOI 10.1038/nrc2734
   Yu QF, 2018, EUR REV MED PHARMACO, V22, P8616, DOI 10.26355/eurrev_201812_16625
   Yuan MS, 2001, SCIENCE, V293, P1673, DOI 10.1126/science.1061620
   Yuan S, 2020, DIABETES, V69, P1588, DOI 10.2337/db20-0084
   Yuan SSF, 2004, GYNECOL ONCOL, V92, P769, DOI 10.1016/j.ygyno.2003.11.043
   Zhao CR, 2020, J EXP CLIN CANC RES, V39, DOI 10.1186/s13046-020-01666-z
   Zhao L, 2005, WORLD J GASTROENTERO, V11, P7666, DOI 10.3748/wjg.v11.i48.7666
   Zhao XB, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000005602
   Zhou H, 2020, DIS MARKERS, V2020, DOI 10.1155/2020/3936247
   Zhou Y, 2015, PANMINERVA MED, V57, P101
   Zhu B, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0176068
   Zhu DH, 2017, CANCER MED-US, V6, P452, DOI 10.1002/cam4.987
   Zhu H, 2011, CELL, V147, P81, DOI 10.1016/j.cell.2011.08.033
   Zhu LH, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000003528
   Zhu X, 2016, BIOCHEM BIOPH RES CO, V469, P319, DOI 10.1016/j.bbrc.2015.11.048
   Zhu ZW, 2013, PLOS ONE, V8, DOI [10.1371/journal.pone.0056662, 10.1371/journal.pone.0080028]
   Zoncu R, 2011, NAT REV MOL CELL BIO, V12, P21, DOI 10.1038/nrm3025
NR 335
TC 19
Z9 21
U1 2
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD OCT
PY 2021
VL 22
IS 20
AR 11137
DI 10.3390/ijms222011137
PG 30
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA WR9FW
UT WOS:000714799600001
PM 34681797
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Arora, T
   Tremaroli, V
AF Arora, Tulika
   Tremaroli, Valentina
TI Therapeutic Potential of Butyrate for Treatment of Type 2 Diabetes
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE type 2 diabetes (T2D); microbiota; butyrate; metabolic disease; short
   chain fatty acids (SCFAs)
ID CHAIN FATTY-ACIDS; RANDOMIZED DOUBLE-BLIND; GUT MICROBIOTA; INTESTINAL
   MICROBIOTA; INSULIN SENSITIVITY; METABOLIC SYNDROME; ENERGY-METABOLISM;
   DONOR FECES; METFORMIN; INDIVIDUALS
AB Metagenomics studies have shown that type 2 diabetes (T2D) is associated with an altered gut microbiota. Whereas different microbiota patterns have been observed in independent human cohorts, reduction of butyrate-producing bacteria has consistently been found in individuals with T2D, as well as in those with prediabetes. Butyrate is produced in the large intestine by microbial fermentations, particularly of dietary fiber, and serves as primary fuel for colonocytes. It also acts as histone deacetylase inhibitor and ligand to G-protein coupled receptors, affecting cellular signaling in target cells, such as enteroendocrine cells. Therefore, butyrate has become an attractive drug target for T2D, and treatment strategies have been devised to increase its intestinal levels, for example by supplementation of butyrate-producing bacteria and dietary fiber, or through fecal microbiota transplant (FMT). In this review, we provide an overview of current literature indicating that these strategies have yielded encouraging results and short-term benefits in humans, but long-term improvements of glycemic control have not been reported so far. Further studies are required to find effective approaches to restore butyrate-producing bacteria and butyrate levels in the human gut, and to investigate their impact on glucose regulation in T2D.
C1 [Arora, Tulika] Univ Copenhagen, Fac Hlth & Med Sci, Ctr Basic Metab Res, Novo Nordisk Fdn, Copenhagen, Denmark.
   [Tremaroli, Valentina] Univ Gothenburg, Sahlgrenska Acad, Dept Mol & Clin Med, Wallenberg Lab,Inst Med, Gothenburg, Sweden.
C3 Novo Nordisk Foundation; University of Copenhagen; University of
   Gothenburg
RP Arora, T (通讯作者)，Univ Copenhagen, Fac Hlth & Med Sci, Ctr Basic Metab Res, Novo Nordisk Fdn, Copenhagen, Denmark.
EM arora@sund.ku.dk
RI Tremaroli, Valentina/AAE-8001-2019
OI Tremaroli, Valentina/0000-0002-9150-4233; Arora,
   Tulika/0000-0001-8821-8191
FU Novo Nordisk Foundation [NNF15OC0016798]
FX This work was supported by Novo Nordisk Foundation (Grant no.
   NNF15OC0016798).
CR Adachi K, 2019, J CLIN BIOCHEM NUTR, V64, P231, DOI 10.3164/jcbn.18-101
   Allin KH, 2018, DIABETOLOGIA, V61, P810, DOI 10.1007/s00125-018-4550-1
   Andreasen AS, 2010, BRIT J NUTR, V104, P1831, DOI 10.1017/S0007114510002874
   Anhe FF, 2020, NAT METAB, V2, P233, DOI 10.1038/s42255-020-0178-9
   Aroda VR, 2017, LANCET DIABETES ENDO, V5, P355, DOI 10.1016/S2213-8587(17)30085-2
   Arora T, 2021, MED-CAMBRIDGE, V2, P553, DOI 10.1016/j.medj.2021.03.018
   Bar N, 2020, NATURE, V588, P135, DOI 10.1038/s41586-020-2896-2
   Baxter M, 2016, J HOSP INFECT, V92, P117, DOI 10.1016/j.jhin.2015.10.024
   Bhute SS, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.00214
   Boets E, 2017, J PHYSIOL-LONDON, V595, P541, DOI 10.1113/JP272613
   Bouter KEC, 2018, CLIN TRANSL GASTROEN, V9, DOI 10.1038/s41424-018-0025-4
   Brooks AW, 2018, PLOS BIOL, V16, DOI 10.1371/journal.pbio.2006842
   Brown AJ, 2003, J BIOL CHEM, V278, P11312, DOI 10.1074/jbc.M211609200
   Bruder LM, 2016, SYST APPL MICROBIOL, V39, P464, DOI 10.1016/j.syapm.2016.08.005
   Byndloss MX, 2017, SCIENCE, V357, P570, DOI 10.1126/science.aam9949
   Cani PD, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.01765
   Cho NH, 2018, DIABETES RES CLIN PR, V138, P271, DOI 10.1016/j.diabres.2018.02.023
   Chriett S, 2017, MOL CELL ENDOCRINOL, V439, P224, DOI 10.1016/j.mce.2016.09.006
   CLARK FM, 1947, FOOD RES, V12, P122
   Clark RL, 2021, NAT COMMUN, V12, DOI 10.1038/s41467-021-22938-y
   Cleophas MCP, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-018-37246-7
   CUMMINGS JH, 1987, GUT, V28, P1221, DOI 10.1136/gut.28.10.1221
   Cunningham AL, 2021, GUT PATHOG, V13, DOI 10.1186/s13099-021-00446-0
   de Groot PF, 2020, DIABETOLOGIA, V63, P597, DOI 10.1007/s00125-019-05073-8
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   de Mello VD, 2017, SCI REP-UK, V7, DOI 10.1038/srep46337
   Deschasaux M, 2018, NAT MED, V24, P1526, DOI 10.1038/s41591-018-0160-1
   Dobbins RL, 2013, DIABETES OBES METAB, V15, P1013, DOI 10.1111/dom.12132
   Dobbins R, 2015, EUR J PHARMACOL, V755, P95, DOI 10.1016/j.ejphar.2015.03.005
   Donohoe DR, 2011, CELL METAB, V13, P517, DOI 10.1016/j.cmet.2011.02.018
   Doumatey AP, 2020, FRONT CELL INFECT MI, V10, DOI 10.3389/fcimb.2020.00063
   Duvallet C, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-01973-8
   Eckburg PB, 2005, SCIENCE, V308, P1635, DOI 10.1126/science.1110591
   Engler C, 2020, BMJ OPEN DIAB RES CA, V8, DOI 10.1136/bmjdrc-2020-001279
   Falony G, 2016, SCIENCE, V352, P560, DOI 10.1126/science.aad3503
   Ferrario C, 2014, J NUTR, V144, P1787, DOI 10.3945/jn.114.197723
   FLEMING SE, 1983, J NUTR, V113, P1613, DOI 10.1093/jn/113.8.1613
   Flint HJ, 2012, NAT REV GASTRO HEPAT, V9, P577, DOI 10.1038/nrgastro.2012.156
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Gao F, 2019, FRONT PHARMACOL, V10, DOI 10.3389/fphar.2019.01040
   Gao ZG, 2009, DIABETES, V58, P1509, DOI 10.2337/db08-1637
   Gargari G, 2016, APPL ENVIRON MICROB, V82, P5850, DOI 10.1128/AEM.01753-16
   Gilijamse PW, 2020, NPJ BIOFILMS MICROME, V6, DOI 10.1038/s41522-020-0127-0
   Gill SR, 2006, SCIENCE, V312, P1355, DOI 10.1126/science.1124234
   Goodman AL, 2011, P NATL ACAD SCI USA, V108, P6252, DOI 10.1073/pnas.1102938108
   Gurung M, 2020, EBIOMEDICINE, V51, DOI 10.1016/j.ebiom.2019.11.051
   Henagan TM, 2015, BRIT J PHARMACOL, V172, P2782, DOI 10.1111/bph.13058
   Hu SX, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21041542
   Human Microbiome Project Consortium, 2012, Nature, V486, P207, DOI 10.1038/nature11234
   Husted AS, 2017, CELL METAB, V25, P777, DOI 10.1016/j.cmet.2017.03.008
   Jia LL, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-07335-0
   Jie ZY, 2021, GASTROENTEROLOGY, V160, P2029, DOI 10.1053/j.gastro.2021.01.029
   Kalantar-Zadeh K, 2019, NAT REV GASTRO HEPAT, V16, P733, DOI 10.1038/s41575-019-0193-z
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Khan S, 2016, CHEM-BIOL INTERACT, V254, P124, DOI 10.1016/j.cbi.2016.06.007
   Kimura I, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms2852
   Koeth RA, 2013, NAT MED, V19, P576, DOI 10.1038/nm.3145
   Koh A, 2018, CELL, V175, P947, DOI 10.1016/j.cell.2018.09.055
   Kootte RS, 2017, CELL METAB, V26, P611, DOI 10.1016/j.cmet.2017.09.008
   Krautkramer KA, 2021, NAT REV MICROBIOL, V19, P77, DOI 10.1038/s41579-020-0438-4
   Langella P, 2019, FRONT MICROBIOL, V10, DOI 10.3389/fmicb.2019.01973
   Larraufie P, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-017-18259-0
   Lee H, 2018, GUT MICROBES, V9, P155, DOI 10.1080/19490976.2017.1405209
   Li JH, 2014, NAT BIOTECHNOL, V32, P834, DOI 10.1038/nbt.2942
   Ling C, 2019, CELL METAB, V29, P1028, DOI 10.1016/j.cmet.2019.03.009
   Louis P, 2017, ENVIRON MICROBIOL, V19, P29, DOI 10.1111/1462-2920.13589
   Louis P, 2010, ENVIRON MICROBIOL, V12, P304, DOI 10.1111/j.1462-2920.2009.02066.x
   Maier L, 2018, NATURE, V555, P623, DOI 10.1038/nature25979
   Martin R, 2019, FRONT MICROBIOL, V10, DOI 10.3389/fmicb.2019.01047
   Matheus VA, 2017, EXP BIOL MED, V242, P1214, DOI 10.1177/1535370217708188
   Milligan G, 2017, CHEM REV, V117, P67, DOI 10.1021/acs.chemrev.6b00056
   Mobini R, 2017, DIABETES OBES METAB, V19, P579, DOI 10.1111/dom.12861
   Mocanu V, 2021, NAT MED, V27, P1272, DOI 10.1038/s41591-021-01399-2
   Noureldein MH, 2020, J MOL ENDOCRINOL, V64, P29, DOI 10.1530/JME-19-0132
   O'Hara AM, 2006, EMBO REP, V7, P688, DOI 10.1038/sj.embor.7400731
   Perraudeau F, 2020, BMJ OPEN DIAB RES CA, V8, DOI 10.1136/bmjdrc-2020-001319
   Petersen N, 2014, DIABETES, V63, P410, DOI 10.2337/db13-0991
   Pryde SE, 2002, FEMS MICROBIOL LETT, V217, P133, DOI 10.1111/j.1574-6968.2002.tb11467.x
   Pryor R, 2019, CELL, V178, P1299, DOI 10.1016/j.cell.2019.08.003
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Qin JJ, 2010, NATURE, V464, P59, DOI 10.1038/nature08821
   Rampelli S, 2015, CURR BIOL, V25, P1682, DOI 10.1016/j.cub.2015.04.055
   Reitmeier S, 2020, CELL HOST MICROBE, V28, P258, DOI 10.1016/j.chom.2020.06.004
   Ridaura VK, 2013, SCIENCE, V341, P1079, DOI 10.1126/science.1241214
   Rodriguez J, 2020, GUT, V69, P1975, DOI 10.1136/gutjnl-2019-319726
   Roshanravan N, 2017, HORM METAB RES, V49, P886, DOI 10.1055/s-0043-119089
   Salonen A, 2012, CLIN MICROBIOL INFEC, V18, P16, DOI 10.1111/j.1469-0691.2012.03855.x
   Sanna S, 2019, NAT GENET, V51, P600, DOI 10.1038/s41588-019-0350-x
   Sato FT, 2020, CELLS-BASEL, V9, DOI 10.3390/cells9092007
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Simon MC, 2015, DIABETES CARE, V38, P1827, DOI 10.2337/dc14-2690
   Suau A, 1999, APPL ENVIRON MICROB, V65, P4799
   Sun J, 2016, BRIT J NUTR, V115, P1167, DOI 10.1017/S0007114516000076
   Tabak AG, 2012, LANCET, V379, P2279, DOI 10.1016/S0140-6736(12)60283-9
   Thingholm LB, 2019, CELL HOST MICROBE, V26, P252, DOI 10.1016/j.chom.2019.07.004
   Tolhurst G, 2012, DIABETES, V61, P364, DOI 10.2337/db11-1019
   Tunaru S, 2003, NAT MED, V9, P352, DOI 10.1038/nm824
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Turnbaugh PJ, 2009, NATURE, V457, P480, DOI 10.1038/nature07540
   Udayappan S, 2016, NPJ BIOFILMS MICROBI, V2, DOI 10.1038/npjbiofilms.2016.9
   van Nood E, 2013, NEW ENGL J MED, V368, P2145, DOI [10.1056/NEJMoa1205037, 10.1056/NEJMc1303919]
   Vital M, 2017, MSYSTEMS, V2, DOI 10.1128/mSystems.00130-17
   Vital M, 2014, MBIO, V5, DOI 10.1128/mBio.00889-14
   Vrieze A, 2012, GASTROENTEROLOGY, V143, P913, DOI 10.1053/j.gastro.2012.06.031
   Wichmann A, 2013, CELL HOST MICROBE, V14, P582, DOI 10.1016/j.chom.2013.09.012
   Wu H, 2020, CELL METAB, V32, P379, DOI 10.1016/j.cmet.2020.06.011
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Yatsunenko T, 2012, NATURE, V486, P222, DOI 10.1038/nature11053
   Yuille S, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0201073
   Zaneveld JR, 2017, NAT MICROBIOL, V2, DOI 10.1038/nmicrobiol.2017.121
   Zhang L, 2021, TRENDS ENDOCRIN MET, V32, P159, DOI 10.1016/j.tem.2020.12.003
   Zhao LJ, 2019, ENDOCRINE, V66, P526, DOI 10.1007/s12020-019-02103-8
   Zhao LP, 2018, SCIENCE, V359, P1151, DOI 10.1126/science.aao5774
NR 113
TC 18
Z9 18
U1 5
U2 18
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD OCT 19
PY 2021
VL 12
AR 761834
DI 10.3389/fendo.2021.761834
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA ZK7PA
UT WOS:000763177000001
PM 34737725
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Ho-Plagaro, A
   Santiago-Fernandez, C
   Garcia-Serrano, S
   Rodriguez, C
   Garrido-Sanchez, L
   Escamilla, A
   Gonzalo, M
   Montiel-Casado, C
   Alcain-Martinez, G
   Garcia-Munoz, B
   Ruiz-Santana, N
   Vazquez-Pedreno, L
   Garcia-Fuentes, E
AF Ho-Plagaro, Ailec
   Santiago-Fernandez, Concepcion
   Garcia-Serrano, Sara
   Rodriguez, Cristina
   Garrido-Sanchez, Lourdes
   Escamilla, Alejandro
   Gonzalo, Montserrat
   Montiel-Casado, Custodia
   Alcain-Martinez, Guillermo
   Garcia-Munoz, Beatriz
   Ruiz-Santana, Natalia
   Vazquez-Pedreno, Luis
   Garcia-Fuentes, Eduardo
TI A lower duodenal immune response is associated with an increase of
   insulin resistance in patients with morbid obesity
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Article
ID HIGH-FAT DIET; HOST-DEFENSE; INFLAMMATION; CELLS; SENSITIVITY;
   ACTIVATION; EXPRESSION; MICROBIOTA; INFECTION; CYTOKINES
AB Objective The intestinal immune response could play an important role in obesity-related comorbidities. We aim to study the profile of duodenal cytokines and chemokines in patients with morbid obesity (MO), its relation with insulin resistance (IR) and the intake of metformin, and with the evolution of MO after sleeve gastrectomy (SG). Research design and methods Duodenal levels of 24 cytokines and 9 chemokines were analyzed in 14 nonobese and in 54 MO who underwent SG: with lower IR (MO-lower-IR), with higher IR (MO-higher-IR), and with type 2 diabetes treated with metformin (MO-metf-T2DM). Results MO-lower-IR had higher levels of cytokines related to Th1, Th2, Th9, Th17, Th22, M1 macrophages, and chemokines involved in the recruitment of macrophages and T-lymphocytes (p < 0.05), and total (CD68 expression) and M1 macrophages (ITGAX expression) (p < 0.05) when compared with nonobese patients, but with a decrease in M2 macrophages (MRC1 expression) (p < 0.05). In MO-higher-IR, these chemokines and cytokines decreased and were similar to those found in nonobese patients. In MO-metf-T2DM, only IL-4 (Th2) and IL-22 (Th22) increased their levels with regard to MO-higher-IR (p < 0.05). In MO-higher-IR and MO-metf-T2DM, there was a decrease of CD68 expression (p < 0.05) while ITGAX and MRC1 were similar with regard to MO-lower-IR. We found an association between CXCL8, TNF beta and IL-2 with the evolution of body mass index (BMI) after SG (p < 0.05). Conclusions There is an association between a higher IR and a lower duodenal immune response in MO, with a slight increase in those patients with metformin treatment. Intestinal immune response could be involved in the evolution of BMI after SG.
C1 [Ho-Plagaro, Ailec; Santiago-Fernandez, Concepcion; Garcia-Serrano, Sara; Rodriguez, Cristina; Garrido-Sanchez, Lourdes; Escamilla, Alejandro; Alcain-Martinez, Guillermo; Garcia-Fuentes, Eduardo] Inst Invest Biomed Malaga IBIMA, Malaga, Spain.
   [Ho-Plagaro, Ailec; Santiago-Fernandez, Concepcion; Rodriguez, Cristina; Alcain-Martinez, Guillermo; Garcia-Munoz, Beatriz; Ruiz-Santana, Natalia; Garcia-Fuentes, Eduardo] Hosp Univ Virgen de la Victoria, Unidad Gest Clin Aparato Digest, Malaga, Spain.
   [Ho-Plagaro, Ailec] Univ Malaga, Malaga, Spain.
   [Garcia-Serrano, Sara; Gonzalo, Montserrat] Hosp Reg Univ Malaga, Unidad Gest Clin Endocrinol & Nutr, Malaga, Spain.
   [Garcia-Serrano, Sara] CIBER Diabet & Enfermedades Metabol Asociadas CIB, Malaga, Spain.
   [Garrido-Sanchez, Lourdes] Hosp Univ Virgen de la Victoria, Unidad Gest Clin Endocrinol & Nutr, Malaga, Spain.
   [Garrido-Sanchez, Lourdes; Garcia-Fuentes, Eduardo] CIBER Fisiol Obesidad & Nutr CIBEROBN, Malaga, Spain.
   [Montiel-Casado, Custodia] Hosp Reg Univ Malaga, Unidad Gest Clin Cirugia Gen Digest & Trasplantes, Malaga, Spain.
   [Vazquez-Pedreno, Luis] Hosp Reg Univ Malaga, Unidad Gest Clin Aparato Digest, Malaga, Spain.
C3 Instituto de Investigacion Biomedica de Malaga y Plataforma en
   Nanomedicina (IBIMA); Universidad de Malaga; Universidad de Malaga;
   Universidad de Malaga; CIBER - Centro de Investigacion Biomedica en Red;
   CIBERDEM; Universidad de Malaga; CIBER - Centro de Investigacion
   Biomedica en Red; CIBEROBN
RP Garrido-Sanchez, L; Garcia-Fuentes, E (通讯作者)，Inst Invest Biomed Malaga IBIMA, Malaga, Spain.; Garcia-Fuentes, E (通讯作者)，Hosp Univ Virgen de la Victoria, Unidad Gest Clin Aparato Digest, Malaga, Spain.; Garrido-Sanchez, L (通讯作者)，Hosp Univ Virgen de la Victoria, Unidad Gest Clin Endocrinol & Nutr, Malaga, Spain.; Garrido-Sanchez, L; Garcia-Fuentes, E (通讯作者)，CIBER Fisiol Obesidad & Nutr CIBEROBN, Malaga, Spain.
EM lourgarrido@gmail.com; edugf1@gmail.com
RI Escamilla, Alejandro/HTR-2875-2023
OI Santiago Fernandez, Conchi/0000-0003-4439-6863; Ho-Plagaro,
   Ailec/0000-0003-0135-2852; Rodriguez Diaz, Cristina/0000-0002-2442-2908;
   Escamilla Sanchez, Alejandro/0000-0001-9135-5330
FU Instituto de Salud Carlos III, Spain [PI12/00338]; FEDER funds;
   Ministerio de Educacion y Formacion Professional (Spain) [FPU14/01972];
   ISCIII (Spain) [FI16/00241]; Miguel Servet program from the ISCIII
   (Spain) [MS13/00188]; BEIPD-COFUND-OPD, (Belgium)
   [R.EURO.0992-J-F-B-32]; Nicolas Monardes program from the Consejeria de
   Salud de Andalucia (Spain) [C-0031-2016]
FX CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN) and CIBER de
   Diabetes y Enfermedades Metabolicas (CIBERDEM) are initiatives of ISCIII
   (Spain). We gratefully acknowledge the Imaging platform of the Institute
   of Biomedical Research in Malaga (IBIMA) (Spain). This work was
   supported in part by a grant from the Instituto de Salud Carlos III,
   Spain (PI12/00338) ("Una manera de hacer Europa"). This study has been
   co-funded by FEDER funds. AHP is supported by a grant from the
   Ministerio de Educacion y Formacion Professional (Spain) (FPU14/01972).
   CSF is supported by a grant from the ISCIII (Spain) (FI16/00241). LGS is
   supported by the Miguel Servet program from the ISCIII (Spain)
   (MS13/00188). CR is supported by a grant from BEIPD-COFUND-OPD,
   (Belgium) (R.EURO.0992-J-F-B-32). EGF is supported by the Nicolas
   Monardes program from the Consejeria de Salud de Andalucia (Spain)
   (C-0031-2016).
CR Araujo JR, 2017, BIOCHIMIE, V141, P97, DOI 10.1016/j.biochi.2017.05.019
   Barbarroja N, 2010, BIOCHEM J, V430, P141, DOI 10.1042/BJ20100285
   Bayer AL, 2013, IMMUNOL RES, V57, P197, DOI 10.1007/s12026-013-8452-5
   Bisgaard LS, 2016, SCI REP-UK, V6, DOI 10.1038/srep35234
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   Cani PD, 2012, GUT MICROBES, V3, P279, DOI 10.4161/gmic.19625
   Crane MJ, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0086660
   Dalmas E, 2014, DIABETES, V63, P1966, DOI 10.2337/db13-1511
   Dickensheets HL, 1997, J IMMUNOL, V159, P6226
   Ding SL, 2011, CURR OPIN CLIN NUTR, V14, P328, DOI 10.1097/MCO.0b013e3283478727
   Escamilla A, 2016, VET PARASITOL, V216, P84, DOI 10.1016/j.vetpar.2015.12.013
   Garcia-Fuentes E, 2006, OBES SURG, V16, P1179, DOI 10.1381/096089206778392383
   Gutierrez-Repiso C, 2017, SURG OBES RELAT DIS, V13, P623, DOI 10.1016/j.soard.2016.11.021
   HARD G C, 1970, British Journal of Experimental Pathology, V51, P97
   Hussaarts L, 2015, FASEB J, V29, P3027, DOI 10.1096/fj.14-266239
   Kaplan MH, 2013, IMMUNOL REV, V252, P104, DOI 10.1111/imr.12028
   Kuhn KA, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0114195
   Licona-Limon P, 2013, IMMUNITY, V39, P744, DOI 10.1016/j.immuni.2013.07.020
   Lindegaard KK, 2015, DIABETOL METAB SYNDR, V7, DOI 10.1186/s13098-015-0012-9
   Lopes EC, 2015, OBES SURG, V25, P1741, DOI 10.1007/s11695-015-1777-5
   Lumeng CN, 2007, J CLIN INVEST, V117, P175, DOI 10.1172/JCI29881
   Mantovani A, 2013, J PATHOL, V229, P176, DOI 10.1002/path.4133
   Moreno-Navarrete JM, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0037160
   Martinez FO, 2008, FRONT BIOSCI-LANDMRK, V13, P453, DOI 10.2741/2692
   Molofsky AB, 2013, J EXP MED, V210, P535, DOI 10.1084/jem.20121964
   Monteiro-Sepulveda M, 2015, CELL METAB, V22, P113, DOI 10.1016/j.cmet.2015.05.020
   Obermeier F, 2006, EUR J IMMUNOL, V36, P2691, DOI 10.1002/eji.200535173
   Raphael I, 2015, CYTOKINE, V74, P5, DOI 10.1016/j.cyto.2014.09.011
   Richard C, 2017, BMJ OPEN DIAB RES CA, V5, DOI 10.1136/bmjdrc-2016-000379
   Rodriguez-Pacheco F, 2014, MOL NUTR FOOD RES, V58, P1852, DOI 10.1002/mnfr.201300666
   Rotter V, 2003, J BIOL CHEM, V278, P45777, DOI 10.1074/jbc.M301977200
   Ruddle NH, 2014, CYTOKINE GROWTH F R, V25, P83, DOI 10.1016/j.cytogfr.2014.02.001
   Sallusto F, 1998, IMMUNOL TODAY, V19, P568, DOI 10.1016/S0167-5699(98)01346-2
   Sieweke MH, 2013, SCIENCE, V342, P946, DOI 10.1126/science.1242974
   Smith JM, 2005, AM J PHYSIOL-GASTR L, V288, pG316, DOI 10.1152/ajpgi.00208.2004
   Veilleux A, 2015, BMC GASTROENTEROL, V15, DOI 10.1186/s12876-015-0342-y
   Wang LJ, 2008, WORLD J GASTROENTERO, V14, P5125, DOI 10.3748/wjg.14.5125
   Winer DA, 2016, CELL METAB, V23, P413, DOI 10.1016/j.cmet.2016.01.003
   Winer DA, 2011, NAT MED, V17, P610, DOI 10.1038/nm.2353
   Wynn TA, 2015, NAT REV IMMUNOL, V15, P271, DOI 10.1038/nri3831
   Ye JP, 2013, AM J PHYSIOL-ENDOC M, V304, pE466, DOI 10.1152/ajpendo.00266.2012
   Zeyda M, 2009, GERONTOLOGY, V55, P379, DOI 10.1159/000212758
   Zheng Y, 2008, NAT MED, V14, P282, DOI 10.1038/nm1720
NR 44
TC 6
Z9 7
U1 0
U2 7
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0307-0565
EI 1476-5497
J9 INT J OBESITY
JI Int. J. Obes.
PD FEB
PY 2020
VL 44
IS 2
BP 340
EP 352
DI 10.1038/s41366-019-0458-1
PG 13
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA KH6IC
UT WOS:000510753800008
PM 31554917
DA 2023-06-08
ER

PT J
AU Libowitz, MR
   Nurmi, EL
AF Libowitz, Mark R.
   Nurmi, Erika L.
TI The Burden of Antipsychotic-Induced Weight Gain and Metabolic Syndrome
   in Children
SO FRONTIERS IN PSYCHIATRY
LA English
DT Review
DE child psychiatry; pediatrics; antipsychotics; antipsychotic-induced
   weight gain; adverse drug effects; metabolic syndrome
ID EARLY-ONSET SCHIZOPHRENIA; BETAHISTINE CO-TREATMENT; SEVERE
   MENTAL-ILLNESS; 5-HT2C RECEPTOR GENE; ATYPICAL ANTIPSYCHOTICS;
   LONG-TERM; DOUBLE-BLIND; BODY-WEIGHT; 2ND-GENERATION ANTIPSYCHOTICS; GUT
   MICROBIOME
AB Antipsychotic medications are critical to child and adolescent psychiatry, from the stabilization of psychotic disorders like schizophrenia, bipolar disorder, and psychotic depression to behavioral treatment of autism spectrum disorder, tic disorders, and pediatric aggression. While effective, these medications carry serious risk of adverse events-most commonly, weight gain and cardiometabolic abnormalities. Negative metabolic consequences affect up to 60% of patients and present a major obstacle to long-term treatment. Since antipsychotics are often chronically prescribed beginning in childhood, cardiometabolic risk accumulates. An increased susceptibility to antipsychotic-induced weight gain (AIWG) has been repeatedly documented in children, particularly rapid weight gain. Associated cardiometabolic abnormalities include central obesity, insulin resistance, dyslipidemia, and systemic inflammation. Lifestyle interventions and medications such as metformin have been proposed to reduce risk but remain limited in efficacy. Furthermore, antipsychotic medications touted to be weight-neutral in adults can cause substantial weight gain in children. A better understanding of the biological underpinnings of AIWG could inform targeted and potentially more fruitful treatments; however, little is known about the underlying mechanism. As yet, modest genetic studies have nominated a few risk genes that explain only a small percentage of the risk. Recent investigations have begun to explore novel potential mechanisms of AIWG, including a role for gut microbiota and microbial metabolites. This article reviews the problem of AIWG and AP metabolic side effects in pediatric populations, proposed mechanisms underlying this serious side effect, and strategies to mitigate adverse impact. We suggest future directions for research efforts that may advance the field and lead to improved clinical interventions.
C1 [Libowitz, Mark R.; Nurmi, Erika L.] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Semel Inst Neurosci & Human Behav, Los Angeles, CA 90095 USA.
C3 University of California System; University of California Los Angeles
RP Nurmi, EL (通讯作者)，Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Semel Inst Neurosci & Human Behav, Los Angeles, CA 90095 USA.
EM enurmi@g.ucla.edu
OI Libowitz, Mark/0000-0002-6143-772X
FU NICHD [R21 HD095548-01]
FX This work was supported by the NICHD R21 HD095548-01.
CR Ader M, 2008, J PSYCHIATR RES, V42, P1076, DOI 10.1016/j.jpsychires.2008.01.004
   Akbaba G, 2018, GYNECOL ENDOCRINOL, V34, P849, DOI 10.1080/09513590.2018.1460659
   Alexander GC, 2011, PHARMACOEPIDEM DR S, V20, P177, DOI 10.1002/pds.2082
   Alladi CG, 2017, J PHARMACOL PHARMACO, V8, P28, DOI 10.4103/jpp.JPP_197_16
   Alvarez-Jimenez M, 2008, CNS DRUGS, V22, P547, DOI 10.2165/00023210-200822070-00002
   Amer Diabet Assoc, 2004, DIABETES CARE, V27, P596, DOI 10.2337/diacare.27.2.596
   Anagnostou E, 2016, JAMA PSYCHIAT, V73, P928, DOI 10.1001/jamapsychiatry.2016.1232
   Andersen SW, 2005, J CLIN PSYCHIAT, V66, P1468, DOI 10.4088/JCP.v66n1118
   Andrade SE, 2011, PEDIATRICS, V128, P1135, DOI 10.1542/peds.2011-0855
   Arango C, 2017, EUR ARCH PSY CLIN N, V267, P1, DOI 10.1007/s00406-016-0765-7
   Arman S, 2008, SAUDI MED J, V29, P1130
   Bachmann CJ, 2014, DTSCH ARZTEBL INT, V111, P25, DOI 10.3238/arztebl.2014.0025
   Baeza I, 2017, EUR CHILD ADOLES PSY, V26, P35, DOI 10.1007/s00787-016-0866-x
   Bahr SM, 2015, TRANSL PSYCHIAT, V5, DOI 10.1038/tp.2015.135
   Bahr SM, 2015, EBIOMEDICINE, V2, P1725, DOI 10.1016/j.ebiom.2015.10.018
   Ballon JS, 2014, TRENDS ENDOCRIN MET, V25, P593, DOI 10.1016/j.tem.2014.07.004
   Barak N, 2016, J PSYCHOPHARMACOL, V30, P237, DOI 10.1177/0269881115626349
   Barsh GS, 2002, NAT REV GENET, V3, P589, DOI [10.1038/nrn902, 10.1038/nrg862]
   Bartoli F, 2015, PSYCHONEUROENDOCRINO, V56, P179, DOI 10.1016/j.psyneuen.2015.03.012
   Belkaid Y, 2014, CELL, V157, P121, DOI 10.1016/j.cell.2014.03.011
   Besnard J, 2012, NATURE, V492, P215, DOI 10.1038/nature11691
   Bobo WV, 2013, JAMA PSYCHIAT, V70, P1067, DOI 10.1001/jamapsychiatry.2013.2053
   Border R, 2019, AM J PSYCHIAT, V176, P376, DOI 10.1176/appi.ajp.2018.18070881
   Borgo F, 2017, CHILD OBES, V13, P78, DOI 10.1089/chi.2015.0194
   Bowden CL, 2005, J CLIN PSYCHIAT, V66, P12
   Brandl EJ, 2016, PHARMACOGENOMICS J, V16, P352, DOI 10.1038/tpj.2015.59
   Brandl EJ, 2012, PROG NEURO-PSYCHOPH, V38, P134, DOI 10.1016/j.pnpbp.2012.03.001
   Bretler T, 2019, BMC MED, V17, DOI 10.1186/s12916-019-1346-1
   Burcu M, 2017, J AM ACAD CHILD PSY, V56, P642, DOI 10.1016/j.jaac.2017.04.004
   Burcu M, 2014, J CHILD ADOL PSYCHOP, V24, P112, DOI 10.1089/cap.2013.0094
   Cajochen C, 2003, J NEUROENDOCRINOL, V15, P432, DOI 10.1046/j.1365-2826.2003.00989.x
   Calarge CA, 2014, J CHILD ADOL PSYCHOP, V24, P120, DOI 10.1089/cap.2013.0126
   Calarge CA, 2012, J PEDIATR-US, V161, P1010, DOI 10.1016/j.jpeds.2012.05.051
   Calarge CA, 2009, J CHILD ADOL PSYCHOP, V19, P101, DOI 10.1089/cap.2008.007
   Casey DE, 2003, PSYCHOPHARMACOLOGY, V166, P391, DOI 10.1007/s00213-002-1344-3
   Castaner O, 2018, INT J ENDOCRINOL, V2018, DOI 10.1155/2018/4095789
   Chen MX, 2017, OBES RES CLIN PRACT, V11, P227, DOI 10.1016/j.orcp.2016.07.004
   Chowdhury NI, 2013, PHARMACOGENOMICS J, V13, P272, DOI 10.1038/tpj.2011.66
   Cipolla-Neto J, 2014, J PINEAL RES, V56, P371, DOI 10.1111/jpi.12137
   Cooper SJ, 2016, J PSYCHOPHARMACOL, V30, P717, DOI 10.1177/0269881116645254
   Cooper WO, 2004, ARCH PEDIAT ADOL MED, V158, P753, DOI 10.1001/archpedi.158.8.753
   Corfitsen HT, 2020, ACTA NEUROPSYCHIATR, V32, P72, DOI 10.1017/neu.2019.41
   Correll CU, 2010, EUR PSYCHIAT, V25, pS12, DOI 10.1016/S0924-9338(10)71701-6
   Correll CU, 2020, WORLD PSYCHIATRY, V19, P69, DOI 10.1002/wps.20714
   Correll CU, 2014, JAMA PSYCHIAT, V71, P1350, DOI 10.1001/jamapsychiatry.2014.1314
   Correll CU, 2011, TRENDS MOL MED, V17, P97, DOI 10.1016/j.molmed.2010.10.010
   Correll CU, 2009, JAMA-J AM MED ASSOC, V302, P1765, DOI 10.1001/jama.2009.1549
   Crystal S, 2009, HEALTH AFFAIR, V28, pW770, DOI 10.1377/hlthaff.28.5.w770
   Curtis LH, 2005, ARCH PEDIAT ADOL MED, V159, P362, DOI 10.1001/archpedi.159.4.362
   Czerwensky F, 2013, INT J NEUROPSYCHOPH, V16, P2103, DOI 10.1017/S1461145713000849
   Czerwensky F, 2013, J CLIN PSYCHOPHARM, V33, P74, DOI 10.1097/JCP.0b013e31827772db
   Davey KJ, 2013, TRANSL PSYCHIAT, V3, DOI 10.1038/tp.2013.83
   Davey KJ, 2012, PSYCHOPHARMACOLOGY, V221, P155, DOI 10.1007/s00213-011-2555-2
   Dayabandara M, 2017, NEUROPSYCH DIS TREAT, V13, DOI 10.2147/NDT.S113099
   De Hert M, 2011, EUR PSYCHIAT, V26, P144, DOI 10.1016/j.eurpsy.2010.09.011
   De Luca V, 2011, HUM PSYCHOPHARM CLIN, V26, P386, DOI 10.1002/hup.1219
   DelBello M, 2004, J CLIN PSYCHIAT, V65, P12
   Deng C, 2012, J PSYCHOPHARMACOL, V26, P1271, DOI 10.1177/0269881112449396
   Detke HC, 2016, J CHILD ADOL PSYCHOP, V26, P922, DOI 10.1089/cap.2016.0010
   Dhaliwal N, 2019, METHODS MOL BIOL, V2011, P531, DOI 10.1007/978-1-4939-9554-7_31
   Dickerson Faith B, 2014, Prim Care Companion CNS Disord, V16, DOI 10.4088/PCC.13m01579
   Indiani CMDP, 2018, CHILD OBES, V14, P501, DOI 10.1089/chi.2018.0040
   Eapen V, 2011, AUSTRALAS PSYCHIATRY, V19, P232, DOI 10.3109/10398562.2010.539609
   Ebdrup BH, 2012, BMC MED, V10, DOI 10.1186/1741-7015-10-92
   Endomba FT, 2020, LIPIDS HEALTH DIS, V19, DOI 10.1186/s12944-020-01203-z
   Espinosa E, 2019, ENDOCRINE, V63, P573, DOI 10.1007/s12020-018-1794-y
   Fang H, 2016, INT CLIN PSYCHOPHARM, V31, P353, DOI 10.1097/YIC.0000000000000142
   Farr OM, 2015, CURR OPIN ENDOCRINOL, V22, P353, DOI 10.1097/MED.0000000000000184
   Fatima Y, 2016, OBES REV, V17, P1154, DOI 10.1111/obr.12444
   Ferrer M, 2013, ENVIRON MICROBIOL, V15, P211, DOI 10.1111/j.1462-2920.2012.02845.x
   Findling RL, 2010, J AM ACAD CHILD PSY, V49, P583, DOI 10.1016/j.jaac.2010.03.013
   Firth J, 2019, SCHIZOPHR RES, V210, P301, DOI 10.1016/j.schres.2018.12.043
   Flak JN, 2016, MOL ENDOCRINOL, V30, P3, DOI 10.1210/me.2015-1232
   Flowers SA, 2017, PHARMACOTHERAPY, V37, P261, DOI 10.1002/phar.1890
   Fonseka TM, 2015, WORLD J BIOL PSYCHIA, V16, P45, DOI 10.3109/15622975.2014.984631
   Fountoulakis KN, 2015, EUR NEUROPSYCHOPHARM, V25, P335, DOI 10.1016/j.euroneuro.2014.11.010
   Fraguas D, 2008, J CLIN PSYCHIAT, V69, P1166, DOI 10.4088/JCP.v69n0717
   Fried SK, 1998, J CLIN ENDOCR METAB, V83, P847, DOI 10.1210/jc.83.3.847
   Fusar-Poli P, 2015, SCHIZOPHRENIA BULL, V41, P892, DOI 10.1093/schbul/sbu170
   Gao KM, 2016, J CLIN PSYCHOPHARM, V36, P637, DOI 10.1097/JCP.0000000000000596
   Gao LL, 2011, PEDIATR DIABETES, V12, P429, DOI 10.1111/j.1399-5448.2010.00747.x
   Garcia-Serna R, 2010, BIOINFORMATICS, V26, P985, DOI 10.1093/bioinformatics/btq061
   Gebhardt S, 2010, J CLIN PHARM THER, V35, P207, DOI 10.1111/j.1365-2710.2009.01084.x
   Gebhardt S, 2009, J PSYCHIATR RES, V43, P620, DOI 10.1016/j.jpsychires.2008.11.001
   Gharipour M, 2017, J GENE MED, V19, DOI 10.1002/jgm.2945
   Ghasemi R, 2013, MOL NEUROBIOL, V47, P1045, DOI 10.1007/s12035-013-8404-z
   Glied S, 2003, HEALTH AFFAIR, V22, P39, DOI 10.1377/hlthaff.22.5.39
   Goetz RL, 2019, SCHIZOPHR RES, V206, P21, DOI 10.1016/j.schres.2018.11.036
   Goh KK, 2019, INT J PSYCHIAT CLIN, V23, P14, DOI 10.1080/13651501.2018.1449864
   Goodarzi MO, 2013, DIABETOLOGIA, V56, P1282, DOI 10.1007/s00125-013-2880-6
   Gorobets LN, 2008, B EXP BIOL MED+, V146, P348, DOI 10.1007/s10517-008-0294-0
   Grajales D, 2019, CELLS-BASEL, V8, DOI 10.3390/cells8111336
   Gregoor JG, 2011, PHARMACOGENOMICS, V12, P919, DOI [10.2217/PGS.11.40, 10.2217/pgs.11.40]
   Gregoor JG, 2010, PSYCHIAT GENET, V20, P311, DOI 10.1097/YPG.0b013e32833b6378
   Gruzdeva O, 2019, DIABET METAB SYND OB, V12, P191, DOI 10.2147/DMSO.S182406
   Guan FL, 2020, SCHIZOPHR RES, V215, P250, DOI 10.1016/j.schres.2019.09.015
   Haack S, 2009, PHARMACOGENOMICS, V10, P1511, DOI [10.2217/pgs.09.102, 10.2217/PGS.09.102]
   Hahn M, 2011, SCHIZOPHR RES, V131, P90, DOI 10.1016/j.schres.2011.06.004
   Halfdanarson O, 2017, EUR NEUROPSYCHOPHARM, V27, P1064, DOI 10.1016/j.euroneuro.2017.07.001
   Hammerman A, 2008, ANN PHARMACOTHER, V42, P1316, DOI 10.1345/aph.1L015
   Handen BL, 2017, J AM ACAD CHILD PSY, V56, P849, DOI 10.1016/j.jaac.2017.07.790
   Haupt DW, 2005, NEUROPSYCHOPHARMACOL, V30, P184, DOI 10.1038/sj.npp.1300563
   Havel PJ, 2001, EXP BIOL MED, V226, P963, DOI 10.1177/153537020122601102
   Heilbronn LK, 2003, CURR PHARM DESIGN, V9, P1411, DOI 10.2174/1381612033454766
   Hellwege JN, 2014, GENE, V534, P33, DOI 10.1016/j.gene.2013.10.035
   Hendrick V, 2017, ANN CLIN PSYCHIATRY, V29, P120
   Herrick-Davis K, 2000, J PHARMACOL EXP THER, V295, P226
   Ho J, 2011, J CAN ACAD CHILD ADO, V20, P234
   Hong CJ, 2010, PHARMACOGENET GENOM, V20, P359, DOI 10.1097/FPC.0b013e3283397d06
   Huang XF, 2007, NEUROSCI RES, V59, P314, DOI 10.1016/j.neures.2007.08.001
   Hume MP, 2017, AM J CLIN NUTR, V105, P790, DOI 10.3945/ajcn.116.140947
   Ishibashi T, 2010, J PHARMACOL EXP THER, V334, P171, DOI 10.1124/jpet.110.167346
   Jasik CB, 2008, ANN NY ACAD SCI, V1135, P265, DOI 10.1196/annals.1429.009
   Jensen KG, 2019, J AM ACAD CHILD PSY, V58, P1062, DOI 10.1016/j.jaac.2019.01.015
   Jerrell Jeanette M, 2012, Prim Care Companion CNS Disord, V14, DOI 10.4088/PCC.11m01185
   Jin H, 2008, SCHIZOPHR RES, V100, P70, DOI 10.1016/j.schres.2007.11.026
   Kadowaki T, 2005, ENDOCR REV, V26, P439, DOI 10.1210/er.2005-0005
   Kahn BB, 2013, CELL METAB, V18, P304, DOI 10.1016/j.cmet.2013.08.015
   Kalverdijk LJ, 2008, PSYCHIAT SERV, V59, P554, DOI 10.1176/ps.2008.59.5.554
   Kang DY, 2018, FRONT PSYCHIATRY, V9, DOI 10.3389/fpsyt.2018.00620
   Kang SG, 2008, PROG NEURO-PSYCHOPH, V32, P160, DOI 10.1016/j.pnpbp.2007.08.002
   Kao ACC, 2018, TRANSL PSYCHIAT, V8, DOI 10.1038/s41398-018-0116-8
   Kapur S, 2000, AM J PSYCHIAT, V157, P514, DOI 10.1176/appi.ajp.157.4.514
   Kaur G, 2002, PROG NEURO-PSYCHOPH, V26, P277, DOI 10.1016/S0278-5846(01)00266-4
   Kawata Y, 2017, EUR J PHARMACOL, V796, P45, DOI 10.1016/j.ejphar.2016.12.018
   Keaton JM, 2017, BIOCOMPUT-PAC SYM, P242, DOI 10.1142/9789813207813_0024
   Keepers GA, 2020, AM J PSYCHIAT, V177, P868, DOI [10.1176/appi.focus.18402, 10.1176/appi.ajp.2020.177901]
   Kelly AS, 2016, ENDOCR DEV, V30, P23, DOI 10.1159/000439323
   Kim SF, 2007, P NATL ACAD SCI USA, V104, P3456, DOI 10.1073/pnas.0611417104
   Kim SH, 2010, J PSYCHIATR RES, V44, P493, DOI 10.1016/j.jpsychires.2009.11.007
   Kjosavik SR, 2017, AUST NZ J PSYCHIAT, V51, P719, DOI 10.1177/0004867417691851
   Koller EA, 2002, PHARMACOTHERAPY, V22, P841, DOI 10.1592/phco.22.11.841.33629
   Koskinen J, 2017, J AM HEART ASSOC, V6, DOI 10.1161/JAHA.117.005632
   Krause M, 2018, EUR NEUROPSYCHOPHARM, V28, P659, DOI 10.1016/j.euroneuro.2018.03.008
   Kroeze WK, 2003, NEUROPSYCHOPHARMACOL, V28, P519, DOI 10.1038/sj.npp.1300027
   Kryzhanovskaya LA, 2012, J CHILD ADOL PSYCHOP, V22, P157, DOI 10.1089/cap.2010.0020
   Kullmann S, 2020, LANCET DIABETES ENDO, V8, P524, DOI 10.1016/S2213-8587(20)30113-3
   Kullmann S, 2013, NEUROENDOCRINOLOGY, V97, P176, DOI 10.1159/000341406
   Kumar S, 2017, MAYO CLIN PROC, V92, P251, DOI 10.1016/j.mayocp.2016.09.017
   Kuzman MR, 2011, PHARMACOGENOMICS J, V11, P35, DOI 10.1038/tpj.2010.7
   Kuzman MR, 2008, PSYCHIAT RES, V160, P308, DOI 10.1016/j.psychres.2007.06.006
   Lane HY, 2006, J CLIN PSYCHOPHARM, V26, P128, DOI 10.1097/01.jcp.0000203196.65710.2b
   Le Hellard S, 2009, MOL PSYCHIATR, V14, P308, DOI 10.1038/sj.mp.4002133
   Lee AK, 2011, PHARMACOGENOMICS, V12, P999, DOI [10.2217/PGS.11.45, 10.2217/pgs.11.45]
   Lee E, 2004, J CLIN PSYCHIAT, V65, P864
   Leibowitz SF, 1998, BIOL PSYCHIAT, V44, P851, DOI 10.1016/S0006-3223(98)00186-3
   Lencz T, 2010, PHARMACOGENET GENOM, V20, P569, DOI 10.1097/FPC.0b013e32833ca24b
   Lett TAP, 2012, MOL PSYCHIATR, V17, P242, DOI 10.1038/mp.2011.109
   Leucht S, 2015, SCHIZOPHRENIA BULL, V41, P549, DOI 10.1093/schbul/sbv019
   Li NN, 2020, FRONT PHARMACOL, V10, DOI 10.3389/fphar.2019.01669
   Li P, 2016, CURR TOP MED CHEM, V16, P3385, DOI 10.2174/1568026616666160608084834
   Lian J., 2010, REDUCE OLANZAPINE IN
   Lian JM, 2016, PHARMACOL RES, V106, P51, DOI 10.1016/j.phrs.2016.02.011
   Lian JM, 2015, PROG NEURO-PSYCHOPH, V56, P75, DOI 10.1016/j.pnpbp.2014.08.006
   Lian JM, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0104160
   Lian JM, 2014, PSYCHONEUROENDOCRINO, V48, P77, DOI 10.1016/j.psyneuen.2014.06.010
   Lian JM, 2013, PROG NEURO-PSYCHOPH, V47, P62, DOI 10.1016/j.pnpbp.2013.08.005
   Liao CH, 2011, SCHIZOPHR RES, V126, P110, DOI 10.1016/j.schres.2010.12.007
   Lieberman JA, 2005, NEW ENGL J MED, V353, P1209, DOI 10.1056/NEJMoa051688
   Lindsay RL, 2004, CLIN PEDIATR, V43, P437, DOI 10.1177/000992280404300504
   Liou YJ, 2012, PHARMACOGENOMICS J, V12, P54, DOI 10.1038/tpj.2010.74
   Maayan L, 2011, J CHILD ADOL PSYCHOP, V21, P517, DOI 10.1089/cap.2011.0015
   Maayan L, 2010, EXPERT REV NEUROTHER, V10, P1175, DOI 10.1586/ERN.10.85
   Maayan L, 2010, NEUROPSYCHOPHARMACOL, V35, P1520, DOI 10.1038/npp.2010.21
   Maciukiewicz M, 2019, SCHIZOPHR RES, V212, P204, DOI 10.1016/j.schres.2019.07.022
   Maciukiewicz M, 2019, J NEURAL TRANSM, V126, P27, DOI 10.1007/s00702-018-1921-1
   Maeda K, 2014, J PHARMACOL EXP THER, V350, P589, DOI 10.1124/jpet.114.213793
   Malhotra AK, 2012, ARCH GEN PSYCHIAT, V69, P904, DOI 10.1001/archgenpsychiatry.2012.191
   Malin SK, 2014, CURR OPIN ENDOCRINOL, V21, P323, DOI 10.1097/MED.0000000000000095
   Mangurian C, 2016, J GEN INTERN MED, V31, P1083, DOI 10.1007/s11606-016-3712-4
   Martinez-Ortega JM, 2013, EUR CHILD ADOLES PSY, V22, P457, DOI 10.1007/s00787-013-0399-5
   Marteene W, 2019, EXPERT OPIN DRUG SAF, V18, P1149, DOI 10.1080/14740338.2019.1674809
   Masaki T, 2001, DIABETES, V50, P385, DOI 10.2337/diabetes.50.2.385
   McClellan J, 2013, J AM ACAD CHILD PSY, V52, P976, DOI 10.1016/j.jaac.2013.02.008
   McCracken JT, 2002, NEW ENGL J MED, V347, P314, DOI 10.1056/NEJMoa013171
   McIntyre RS, 2008, ARCH PEDIAT ADOL MED, V162, P929, DOI 10.1001/archpedi.162.10.929
   Menard ML, 2019, EUR NEUROPSYCHOPHARM, V29, P1397, DOI 10.1016/j.euroneuro.2019.10.006
   Misiak B, 2019, NEUROSCI BIOBEHAV R, V102, P362, DOI 10.1016/j.neubiorev.2019.05.018
   Mitchell AJ, 2013, SCHIZOPHRENIA BULL, V39, P306, DOI 10.1093/schbul/sbr148
   Mizuno Y, 2014, SCHIZOPHRENIA BULL, V40, P1385, DOI 10.1093/schbul/sbu030
   Monteleone P, 2002, J CLIN PSYCHOPHARM, V22, P424, DOI 10.1097/00004714-200208000-00015
   Monteleone P, 2010, J CLIN PSYCHOPHARM, V30, P441, DOI 10.1097/JCP.0b013e3181e742c5
   Morgan AP, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0115225
   Morrato EH, 2010, ARCH PEDIAT ADOL MED, V164, P344, DOI 10.1001/archpediatrics.2010.48
   Morrison JA, 2002, AM J PSYCHIAT, V159, P655, DOI 10.1176/appi.ajp.159.4.655
   Mostafavi Ali, 2014, Acta Med Iran, V52, P734
   Mostafavi SA, 2017, J CHILD ADOL PSYCHOP, V27, P440, DOI 10.1089/cap.2016.0046
   Muller DJ, 2012, PHARMACOGENOMICS J, V12, P156, DOI 10.1038/tpj.2010.65
   Mulder H, 2007, J CLIN PSYCHOPHARM, V27, P338, DOI 10.1097/JCP.0b013e3180a76dc0
   Munafo MR, 2009, MOL PSYCHIATR, V14, P119, DOI 10.1038/mp.2008.77
   Musil R, 2015, EXPERT OPIN DRUG SAF, V14, P73, DOI 10.1517/14740338.2015.974549
   Nasrallah HA, 2008, MOL PSYCHIATR, V13, P27, DOI 10.1038/sj.mp.4002066
   Nicol GE, 2019, J CHILD ADOL PSYCHOP, V29, P439, DOI 10.1089/cap.2018.0120
   Nielsen RE, 2014, J AM ACAD CHILD PSY, V53, P971, DOI 10.1016/j.jaac.2014.04.023
   Noguera A, 2013, J CLIN PSYCHOPHARM, V33, P463, DOI 10.1097/JCP.0b013e3182962480
   Nurmi EL, 2013, TRANSL PSYCHIAT, V3, DOI 10.1038/tp.2013.26
   Nurmi EL, 2019, ALTERED BILE ACID SI
   Nurmi EL, 2018, MICROBIOME BILE ACID
   O'Connor EA, 2017, JAMA-J AM MED ASSOC, V317, P2427, DOI 10.1001/jama.2017.0332
   O'Connor WT, 2015, PHARMACOL THERAPEUT, V150, P47, DOI 10.1016/j.pharmthera.2015.01.005
   Ojala K, 2008, J PSYCHOPHARMACOL, V22, P33, DOI 10.1177/0269881107077815
   Olfson M, 2012, ARCH GEN PSYCHIAT, V69, P1247, DOI 10.1001/archgenpsychiatry.2012.647
   Opgen-Rhein C, 2010, PHARMACOGENOMICS, V11, P773, DOI 10.2217/PGS.10.50
   Ostbye T, 2005, PHARMACOEPIDEM DR S, V14, P407, DOI 10.1002/pds.1016
   Panariello F, 2012, J OBES, V2012, DOI 10.1155/2012/572848
   Pappadopulos E, 2003, J AM ACAD CHILD PSY, V42, P145, DOI 10.1097/00004583-200302000-00008
   Park HK, 2015, METABOLISM, V64, P24, DOI 10.1016/j.metabol.2014.08.004
   Park YM, 2006, AM J MED GENET B, V141B, P394, DOI 10.1002/ajmg.b.30311
   Park YM, 2011, HUM PSYCHOPHARM CLIN, V26, P332, DOI 10.1002/hup.1210
   Patel NC, 2005, J AM ACAD CHILD PSY, V44, P548, DOI 10.1097/01.chi.0000157543.74509.c8
   Pennap D, 2018, JAMA PEDIATR, V172, P576, DOI 10.1001/jamapediatrics.2018.0240
   Pillay J, 2018, CAN J PSYCHIAT, V63, P661, DOI 10.1177/0706743718779950
   Pillinger T, 2020, LANCET PSYCHIAT, V7, P64, DOI 10.1016/S2215-0366(19)30416-X
   Piovani D, 2019, EUR J CLIN PHARMACOL, V75, P1333, DOI 10.1007/s00228-019-02711-3
   Potvin Stephane, 2015, Can J Psychiatry, V60, pS26
   Poyurovsky M, 2013, PSYCHOPHARMACOLOGY, V226, P615, DOI 10.1007/s00213-012-2935-2
   Pozzi M, 2019, J CHILD ADOL PSYCHOP, V29, P133, DOI 10.1089/cap.2018.0092
   Pringsheim T, 2017, J CLIN PSYCHOPHARM, V37, P498, DOI 10.1097/JCP.0000000000000760
   Pringsheim T, 2011, J CHILD ADOL PSYCHOP, V21, P537, DOI 10.1089/cap.2010.0145
   Pringsheim T, 2011, PAED CHILD HEALT-CAN, V16, P581, DOI 10.1093/pch/16.9.581
   Rani F, 2008, PEDIATRICS, V121, P1002, DOI 10.1542/peds.2007-2008
   Raskind MA, 2007, NEUROPSYCHOPHARMACOL, V32, P284, DOI 10.1038/sj.npp.1301093
   Ratzoni G, 2002, J AM ACAD CHILD PSY, V41, P337, DOI 10.1097/00004583-200203000-00014
   Rauser L, 2001, J PHARMACOL EXP THER, V299, P83
   Ravussin Y, 2012, OBESITY, V20, P738, DOI 10.1038/oby.2011.111
   Reyes M, 2006, AM J PSYCHIAT, V163, P402, DOI 10.1176/appi.ajp.163.3.402
   Reynolds GP, 2010, PHARMACOL THERAPEUT, V125, P169, DOI 10.1016/j.pharmthera.2009.10.010
   Reynolds GP, 2002, LANCET, V359, P2086, DOI 10.1016/S0140-6736(02)08913-4
   Rice Jessie, 2020, Med Sci (Basel), V8, DOI 10.3390/medsci8030034
   Richelson E, 2000, LIFE SCI, V68, P29, DOI 10.1016/S0024-3205(00)00911-5
   Ridaura VK, 2013, SCIENCE, V341, P1079, DOI 10.1126/science.1241214
   Ripoli Carlo, 2017, Pediatr Med Chir, V39, P149, DOI 10.4081/pmc.2017.149
   Risselada AJ, 2010, J CLIN PSYCHOPHARM, V30, P667, DOI 10.1097/JCP.0b013e3181fbfac4
   Roerig JL, 2011, CNS DRUGS, V25, P1035, DOI 10.2165/11596300-000000000-00000
   Rubin DM, 2015, JAMA PEDIATR, V169, DOI 10.1001/jamapediatrics.2015.0285
   Ryu S, 2007, PROG NEURO-PSYCHOPH, V31, P673, DOI 10.1016/j.pnpbp.2006.12.021
   Safer DJ, 2004, J CLIN PSYCHOPHARM, V24, P429, DOI 10.1097/01.jcp.0000130558.86125.5b
   Saiz PA, 2008, HUM PSYCHOPHARM CLIN, V23, P107, DOI 10.1002/hup.903
   Santosh PJ, 2017, J CHILD ADOL PSYCHOP, V27, P546, DOI 10.1089/cap.2015.0247
   Saunders KH, 2016, EXPERT OPIN PHARMACO, V17, P2235, DOI 10.1080/14656566.2016.1244527
   Schilling TM, 2014, HUM BRAIN MAPP, V35, P1944, DOI 10.1002/hbm.22304
   Schmid V, 2018, DIABETES OBES METAB, V20, P1563, DOI 10.1111/dom.13279
   Schoemakers RJ, 2019, J CHILD ADOL PSYCHOP, V29, P192, DOI 10.1089/cap.2018.0111
   Seida JC, 2012, PEDIATRICS, V129, pE771, DOI 10.1542/peds.2011-2158
   Sentissi O, 2008, SCHIZOPHRENIA BULL, V34, P1189, DOI 10.1093/schbul/sbm141
   Shapiro DA, 2003, NEUROPSYCHOPHARMACOL, V28, P1400, DOI 10.1038/sj.npp.1300203
   Shapiro M, 2016, INT J PSYCHIAT MED, V51, P56, DOI 10.1177/0091217415621266
   Shen JZ, 2014, PSYCHIAT DANUB, V26, P145
   Shen L, 2011, PHYSIOL BEHAV, V105, P124, DOI 10.1016/j.physbeh.2011.04.018
   Shimomura I, 1996, NAT MED, V2, P800, DOI 10.1038/nm0796-800
   Shin L, 2009, J CHILD ADOL PSYCHOP, V19, P275, DOI 10.1089/cap.2008.094
   Siafis S, 2018, CURR NEUROPHARMACOL, V16, P1210, DOI 10.2174/1570159X15666170630163616
   Sicard MN, 2010, PHARMACOGENOMICS, V11, P1561, DOI [10.2217/pgs.10.123, 10.2217/PGS.10.123]
   Sickert L, 2009, PHARMACOGENOMICS, V10, P1169, DOI [10.2217/pgs.09.43, 10.2217/PGS.09.43]
   Sikich L, 2008, AM J PSYCHIAT, V165, P1420, DOI 10.1176/appi.ajp.2008.08050756
   Simeon J, 2002, PROG NEURO-PSYCHOPH, V26, P267, DOI 10.1016/S0278-5846(01)00264-0
   Simon V, 2009, J CLIN PSYCHIAT, V70, P1041, DOI 10.4088/JCP.08r04392
   Siontis KCM, 2010, EUR J HUM GENET, V18, P832, DOI 10.1038/ejhg.2010.26
   Siskind D, 2019, DIABETES OBES METAB, V21, P293, DOI 10.1111/dom.13522
   Skonieczna-Zydecka K, 2019, PSYCHOPHARMACOLOGY, V236, P1491, DOI 10.1007/s00213-018-5102-6
   Smith GC, 2014, SCHIZOPHR RES, V157, P128, DOI 10.1016/j.schres.2014.05.003
   Smith RC, 2018, PSYCHOPHARMACOLOGY, V235, P3545, DOI 10.1007/s00213-018-5079-1
   Solmi M, 2017, THER CLIN RISK MANAG, V13, P757, DOI 10.2147/TCRM.S117321
   Spor A, 2011, NAT REV MICROBIOL, V9, P279, DOI 10.1038/nrmicro2540
   Steinhausen HC, 2015, EUR CHILD ADOLES PSY, V24, P635, DOI 10.1007/s00787-014-0631-y
   Stigler K A, 2001, Paediatr Drugs, V3, P927, DOI 10.2165/00128072-200103120-00005
   Stubbs B, 2016, PSYCHONEUROENDOCRINO, V63, P144, DOI 10.1016/j.psyneuen.2015.09.026
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Taylor JH, 2018, J CHILD ADOL PSYCHOP, V28, P474, DOI 10.1089/cap.2017.0147
   Tchang BG, 2020, EXPERT OPIN PHARMACO, V21, P21, DOI 10.1080/14656566.2019.1685496
   Teff KL, 2013, DIABETES, V62, P3232, DOI 10.2337/db13-0430
   Teff KL, 2011, PHYSIOL BEHAV, V104, P590, DOI 10.1016/j.physbeh.2011.05.033
   Templeman Lucy A, 2005, Pharmacogenet Genomics, V15, P195, DOI 10.1097/01213011-200504000-00002
   ter Hark SE, 2020, J PSYCHOPHARMACOL, V34, P524, DOI 10.1177/0269881120907972
   Terron MP, 2013, PHYSIOL BEHAV, V118, P8, DOI 10.1016/j.physbeh.2013.04.006
   Tiwari AK, 2010, HUM PSYCHOPHARM CLIN, V25, P253, DOI 10.1002/hup.1111
   Tiwari AK, 2010, NEUROPSYCHOPHARMACOL, V35, P1315, DOI 10.1038/npp.2009.235
   Tomasik J, 2015, BIOMARK INSIGHTS, V10, P47, DOI 10.4137/BMI.S22007
   Townsend LK, 2018, PSYCHONEUROENDOCRINO, V88, P121, DOI 10.1016/j.psyneuen.2017.12.004
   Travis MJ, 1998, BRIT J PSYCHIAT, V173, P236, DOI 10.1192/bjp.173.3.236
   Tsai A, 2011, NEUROMOL MED, V13, P328, DOI 10.1007/s12017-011-8159-5
   Tschritter O, 2006, P NATL ACAD SCI USA, V103, P12103, DOI 10.1073/pnas.0604404103
   Turgay Atilla, 2005, Essent Psychopharmacol, V6, P277
   Turnbaugh PJ, 2008, CELL HOST MICROBE, V3, P213, DOI 10.1016/j.chom.2008.02.015
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Turnbaugh PJ, 2009, NATURE, V457, P480, DOI 10.1038/nature07540
   Tybura P, 2014, PSYCHIAT RES, V219, P261, DOI 10.1016/j.psychres.2014.05.039
   Ucok A, 2008, WORLD PSYCHIATRY, V7, P58
   Uetani N, 2000, EMBO J, V19, P2775, DOI 10.1093/emboj/19.12.2775
   Upadhyay N, 2019, PSYCHIAT RES, V276, P151, DOI 10.1016/j.psychres.2019.05.005
   van der Esch CCL, 2021, EUR CHILD ADOLES PSY, V30, P1263, DOI 10.1007/s00787-020-01614-4
   Vancampfort D, 2019, WORLD PSYCHIATRY, V18, P53, DOI 10.1002/wps.20614
   Vock C, 2008, CELL PHYSIOL BIOCHEM, V22, P515, DOI 10.1159/000185525
   Volpato AM, 2013, REV BRAS PSIQUIATR, V35, P295, DOI 10.1590/1516-4446-2012-1052
   von Wilmsdorff M, 2010, CLINICS, V65, P885, DOI 10.1590/S1807-59322010000900012
   Wakefield S, 2020, AM J THER, V27, pE425, DOI 10.1097/MJT.0000000000000853
   Wang GJ, 2004, J ADDICT DIS, V23, P39, DOI 10.1300/J069v23n03_04
   Wang GJ, 2001, LANCET, V357, P354, DOI 10.1016/S0140-6736(00)03643-6
   Wang HR, 2016, INT CLIN PSYCHOPHARM, V31, P301, DOI 10.1097/YIC.0000000000000135
   Wang YC, 2005, J NEURAL TRANSM, V112, P1463, DOI 10.1007/s00702-005-0291-7
   Weiden PJ, 2003, J CLIN PSYCHIAT, V64, P580, DOI 10.4088/JCP.v64n0514
   Weihe P, 2019, CURR OBES REP, V8, P472, DOI 10.1007/s13679-019-00357-x
   Weyer C, 2001, J CLIN ENDOCR METAB, V86, P1930, DOI 10.1210/jc.86.5.1930
   Wu JJ, 2013, MOL BIOL REP, V40, P5691, DOI 10.1007/s11033-013-2671-7
   Xu BJ, 2003, NAT NEUROSCI, V6, P736, DOI 10.1038/nn1073
   Xu Y, 2010, J NEUROSCI, V30, P14630, DOI 10.1523/JNEUROSCI.5412-09.2010
   Yadav A, 2013, CLIN CHIM ACTA, V417, P80, DOI 10.1016/j.cca.2012.12.007
   Yatsunenko T, 2012, NATURE, V486, P222, DOI 10.1038/nature11053
   Yevtushenko OO, 2008, BRIT J PSYCHIAT, V192, P424, DOI 10.1192/bjp.bp.107.041723
   Yu H, 2016, SCHIZOPHRENIA BULL, V42, P814, DOI 10.1093/schbul/sbv179
   Yu WP, 2013, J CLIN PSYCHOPHARM, V33, P186, DOI 10.1097/JCP.0b013e318283925e
   Zai GCM, 2012, PROG NEURO-PSYCHOPH, V39, P96, DOI 10.1016/j.pnpbp.2012.05.014
   Zhang L, 2011, DIABETES RES CLIN PR, V91, P233, DOI 10.1016/j.diabres.2010.10.016
   Zhang XY, 2008, NEUROPSYCHOPHARMACOL, V33, P2200, DOI 10.1038/sj.npp.1301619
   Zhang YM, 2019, SCI CHINA LIFE SCI, V62, P535, DOI 10.1007/s11427-018-9489-x
   Zhang Y, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0072652
   Zito JM, 2008, PEDIATRICS, V121, pE157, DOI 10.1542/peds.2007-0212
   Zito JM, 2013, PSYCHIAT SERV, V64, P223, DOI 10.1176/appi.ps.201200081
NR 318
TC 16
Z9 16
U1 4
U2 22
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD MAR 12
PY 2021
VL 12
AR 623681
DI 10.3389/fpsyt.2021.623681
PG 24
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA RC2KV
UT WOS:000632634300001
PM 33776816
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Walker, RL
   Vlamakis, H
   Lee, JWJ
   Besse, LA
   Xanthakis, V
   Vasan, RS
   Shaw, SY
   Xavier, RJ
AF Walker, Rebecca L.
   Vlamakis, Hera
   Lee, Jonathan Wei Jie
   Besse, Luke A.
   Xanthakis, Vanessa
   Vasan, Ramachandran S.
   Shaw, Stanley Y.
   Xavier, Ramnik J.
TI Population study of the gut microbiome: associations with diet,
   lifestyle, and cardiometabolic disease
SO GENOME MEDICINE
LA English
DT Article
DE Framingham Heart Study; Gut microbiome; Cardiovascular disease; Type 2
   diabetes; 16S rRNA gene sequencing; Microbial taxonomy
ID METFORMIN; HEALTH; CONTRIBUTES; METABOLISM; METAGENOME; PATTERNS;
   IMMUNITY
AB Background The human gut harbors trillions of microbes that play dynamic roles in health. While the microbiome contributes to many cardiometabolic traits by modulating host inflammation and metabolism, there is an incomplete understanding regarding the extent that and mechanisms by which individual microbes impact risk and development of cardiovascular disease (CVD). The Framingham Heart Study (FHS) is a multi-generational observational study following participants over decades to identify risk factors for CVD by correlating genetic and phenotypic factors with clinical outcomes. As a large-scale population-based cohort with extensive clinical phenotyping, FHS provides a rich landscape to explore the relationships between the gut microbiome and cardiometabolic traits. Methods We performed 16S rRNA gene sequencing on stool from 1423 participants of the FHS Generation 3, OMNI2, and New Offspring Spouse cohorts. Data processing and taxonomic assignment were performed with the 16S bioBakery workflow using the UPARSE pipeline. We conducted statistical analyses to investigate trends in overall microbiome composition and diversity in relation to disease states and systematically examined taxonomic associations with a variety of clinical traits, disease phenotypes, clinical blood markers, and medications. Results We demonstrate that overall microbial diversity decreases with increasing 10-year CVD risk and body mass index measures. We link lifestyle factors, especially diet and exercise, to microbial diversity. Our association analyses reveal both known and unreported microbial associations with CVD and diabetes, related prescription medications, as well as many anthropometric and blood test measurements. In particular, we observe a set of microbial species that demonstrate significant associations with CVD risk, metabolic syndrome, and type 2 diabetes as well as a number of shared associations between microbial species and cardiometabolic subphenotypes. Conclusions The identification of significant microbial taxa associated with prevalent CVD and diabetes, as well as risk for developing CVD, adds to increasing evidence that the microbiome may contribute to CVD pathogenesis. Our findings support new hypothesis generation around shared microbe-mediated mechanisms that influence metabolic syndrome, diabetes, and CVD risk. Further investigation of the gut microbiomes of CVD patients in a targeted manner may elucidate microbial mechanisms with diagnostic and therapeutic implications.
C1 [Walker, Rebecca L.; Vlamakis, Hera; Lee, Jonathan Wei Jie; Besse, Luke A.; Shaw, Stanley Y.; Xavier, Ramnik J.] Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.
   [Vlamakis, Hera; Xavier, Ramnik J.] MIT, Ctr Microbiome Informat & Therapeut, 77 Massachusetts Ave, Cambridge, MA 02139 USA.
   [Lee, Jonathan Wei Jie] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Med, Singapore, Singapore.
   [Lee, Jonathan Wei Jie] Natl Univ Hlth Syst, Div Gastroenterol & Hepatol, Singapore, Singapore.
   [Xanthakis, Vanessa; Vasan, Ramachandran S.] Boston Univ, Framingham, MA USA.
   [Xanthakis, Vanessa; Vasan, Ramachandran S.] NHLBI, Framingham Heart Study, Framingham, MA USA.
   [Xanthakis, Vanessa; Vasan, Ramachandran S.] Boston Univ, Dept Med, Sect Prevent Med & Epidemiol, Sch Med, Boston, MA 02215 USA.
   [Xanthakis, Vanessa] Boston Univ, Dept Biostat, Sch Publ Hlth, Boston, MA 02215 USA.
   [Vasan, Ramachandran S.] Boston Univ, Dept Med, Sect Cardiol, Sch Med, Boston, MA 02215 USA.
   [Shaw, Stanley Y.] Harvard Med Sch, Div Cardiovasc Med, Brigham & Womens Hosp, Boston, MA 02115 USA.
   [Xavier, Ramnik J.] Harvard Med Sch, Ctr Computat & Integrat Biol, Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA 02115 USA.
   [Xavier, Ramnik J.] Broad Inst MIT & Harvard, Klarman Cell Observ, Cambridge, MA 02142 USA.
C3 Harvard University; Massachusetts Institute of Technology (MIT); Broad
   Institute; Massachusetts Institute of Technology (MIT); National
   University of Singapore; National University of Singapore; Boston
   University; Framingham Heart Study; National Institutes of Health (NIH)
   - USA; NIH National Heart Lung & Blood Institute (NHLBI); Boston
   University; Boston University; Boston University; Harvard University;
   Brigham & Women's Hospital; Harvard Medical School; Harvard University;
   Harvard Medical School; Massachusetts General Hospital; Harvard
   University; Massachusetts Institute of Technology (MIT); Broad Institute
RP Vlamakis, H; Shaw, SY; Xavier, RJ (通讯作者)，Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.; Vlamakis, H; Xavier, RJ (通讯作者)，MIT, Ctr Microbiome Informat & Therapeut, 77 Massachusetts Ave, Cambridge, MA 02139 USA.; Shaw, SY (通讯作者)，Harvard Med Sch, Div Cardiovasc Med, Brigham & Womens Hosp, Boston, MA 02115 USA.; Xavier, RJ (通讯作者)，Harvard Med Sch, Ctr Computat & Integrat Biol, Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA 02115 USA.; Xavier, RJ (通讯作者)，Broad Inst MIT & Harvard, Klarman Cell Observ, Cambridge, MA 02142 USA.
EM hera_vlamakis@hms.harvard.edu; Stanley_Shaw@hms.harvard.edu;
   xavier@molbio.mgh.harvard.edu
OI Lee, Jonathan/0000-0001-7065-8041
FU National Institutes of Health [R01 HL131015, RC2 DK114784, P30
   DK043351]; NHLBI [NO1-HC-25195, HHSN268201500001I, 75N92019D00031]
FX This work was supported by funding from the National Institutes of
   Health (R01 HL131015 to S.Y.S., R.S.V., and R.J.X.; RC2 DK114784 and P30
   DK043351 to R.J.X.). This work was also supported by NHLBI Contracts
   NO1-HC-25195, HHSN268201500001I, and 75N92019D00031 (R.S.V.).
CR Ahmad A, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0226372
   Bolte LA, 2021, GUT, V70, P1287, DOI 10.1136/gutjnl-2020-322670
   Briatte F, **DATA OBJECT**
   Butts C., 2020, NETWORK CLASSES RELA
   Butts C., 2008, J STAT SOFTW, V24, P1, DOI DOI 10.18637/JSS.V024.I02
   Caporaso JG, 2012, ISME J, V6, P1621, DOI 10.1038/ismej.2012.8
   Caporaso JG, 2011, P NATL ACAD SCI USA, V108, P4516, DOI 10.1073/pnas.1000080107
   Castaner O, 2018, INT J ENDOCRINOL, V2018, DOI 10.1155/2018/4095789
   Clemente JC, 2012, CELL, V148, P1258, DOI 10.1016/j.cell.2012.01.035
   D'Agostino RB, 2008, CIRCULATION, V117, P743, DOI 10.1161/CIRCULATIONAHA.107.699579
   David LA, 2014, NATURE, V505, P559, DOI 10.1038/nature12820
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Frostegard J, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-117
   Fu JY, 2015, CIRC RES, V117, P817, DOI 10.1161/CIRCRESAHA.115.306807
   Gibbons GH, 2021, NEW ENGL J MED, V384, P785, DOI 10.1056/NEJMp2033115
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000111245.75752.C6
   Huttenhower C, 2012, NATURE, V486, P207, DOI 10.1038/nature11234
   Jie ZY, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-00900-1
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Karlsson FH, 2012, NAT COMMUN, V3, DOI 10.1038/ncomms2266
   Kenny DJ, 2020, CELL HOST MICROBE, V28, P245, DOI 10.1016/j.chom.2020.05.013
   Koeth RA, 2013, NAT MED, V19, P576, DOI 10.1038/nm.3145
   Kolde Raivo, 2019, CRAN
   Kurilshikov A, 2019, CIRC RES, V124, P1808, DOI 10.1161/CIRCRESAHA.118.314642
   Lahti L., 2017, TOOLS MICROBIOME ANA
   Langille MGI, 2013, NAT BIOTECHNOL, V31, P814, DOI 10.1038/nbt.2676
   Le Chatelier E, 2013, NATURE, V500, P541, DOI 10.1038/nature12506
   Li J, 2017, MICROBIOME, V5, DOI 10.1186/s40168-016-0222-x
   Li Q, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-62224-3
   Libby P, 2018, J AM COLL CARDIOL, V71, P173, DOI 10.1016/j.jacc.2017.10.081
   Libby P, 2012, ARTERIOSCL THROM VAS, V32, P2045, DOI 10.1161/ATVBAHA.108.179705
   Lloyd-Price J, 2019, NATURE, V569, P655, DOI 10.1038/s41586-019-1237-9
   Ma S, 2019, MMUPHIN META ANAL ME
   Mallick H, 2021, PLOS COMPUT BIOL, V17, DOI 10.1371/journal.pcbi.1009442
   Manor O, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-18871-1
   McIver LJ, 2018, BIOINFORMATICS, V34, P1235, DOI 10.1093/bioinformatics/btx754
   McLaughlin T, 2017, J CLIN INVEST, V127, P5, DOI 10.1172/JCI88876
   McMurdie PJ, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0061217
   Mei ZD, 2021, AM J CLIN NUTR, V113, P1503, DOI 10.1093/ajcn/nqab001
   Oh TG, 2020, CELL METAB, V32, P878, DOI 10.1016/j.cmet.2020.06.005
   Oksanen J., 2022, PACKAGE VEGAN COMMUN, DOI DOI 10.4135/9781412971874.N145
   Org E, 2017, GENOME BIOL, V18, DOI 10.1186/s13059-017-1194-2
   Paradis E, 2019, BIOINFORMATICS, V35, P526, DOI 10.1093/bioinformatics/bty633
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Schirmer M, 2016, CELL, V167, P1125, DOI 10.1016/j.cell.2016.10.020
   Storey J, 2020, QVALUE Q VALUE ESTIM
   Tang WHW, 2017, CIRC RES, V120, P1183, DOI 10.1161/CIRCRESAHA.117.309715
   Tang WHW, 2015, J CARD FAIL, V21, P91, DOI 10.1016/j.cardfail.2014.11.006
   Tidjani Alou M., 2016, HUM MICROBIOME J, V1, P3, DOI DOI 10.1016/J.HUMIC.2016.09.001
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Turnbaugh PJ, 2009, NATURE, V457, P480, DOI 10.1038/nature07540
   Tuteja S, 2019, CIRC-GENOM PRECIS ME, V12, P421, DOI 10.1161/CIRCGEN.119.002314
   Vatanen T, 2016, CELL, V165, P842, DOI 10.1016/j.cell.2016.04.007
   Vila AV, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-019-14177-z
   Virani SS, 2020, CIRCULATION, V141, pE139, DOI 10.1161/CIR.0000000000000757
   Vuong HE, 2017, BIOL PSYCHIAT, V81, P411, DOI 10.1016/j.biopsych.2016.08.024
   Walker RL., 2021, POPULATION STUDY GUT
   Wang ZN, 2011, NATURE, V472, P57, DOI 10.1038/nature09922
   Wei T., 2017, R PACKAGE CORRPLOT V
   Wickham H., 2016, GGPLOT2 ELEGANT GRAP, DOI 10.1007/978-0-387-98141-3
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Yang T, 2015, HYPERTENSION, V65, P1331, DOI 10.1161/HYPERTENSIONAHA.115.05315
   Zackular JP, 2014, CANCER PREV RES, V7, P1112, DOI 10.1158/1940-6207.CAPR-14-0129
   Zeevi D, 2015, CELL, V163, P1079, DOI 10.1016/j.cell.2015.11.001
   Zhang XY, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0071108
   Zheng DP, 2020, CELL RES, V30, P492, DOI 10.1038/s41422-020-0332-7
   Zhernakova A, 2016, SCIENCE, V352, P565, DOI 10.1126/science.aad3369
   Zhu WF, 2016, CELL, V165, P111, DOI 10.1016/j.cell.2016.02.011
NR 69
TC 11
Z9 11
U1 6
U2 20
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1756-994X
J9 GENOME MED
JI Genome Med.
PD DEC 17
PY 2021
VL 13
IS 1
AR 188
DI 10.1186/s13073-021-01007-5
PG 16
WC Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity
GA XP6XT
UT WOS:000731007000001
PM 34915914
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Chen, C
   You, LJ
   Huang, Q
   Fu, X
   Zhang, B
   Liu, RH
   Li, C
AF Chen, Chun
   You, Li-Jun
   Huang, Qiang
   Fu, Xiong
   Zhang, Bin
   Liu, Rui-Hai
   Li, Chao
TI Modulation of gut microbiota by mulberry fruit polysaccharide treatment
   of obese diabetic db/db mice
SO FOOD & FUNCTION
LA English
DT Article
ID HEPATOPROTECTIVE ACTIVITIES; HIGH-FAT; ANTIOXIDANT; DIET; MECHANISMS;
   IMPACT; EXTRACT; GLUCOSE
AB Increasing evidence indicates that gut microbiota is an important factor in mediating the development of metabolic disorders, especially type 2 diabetes. Herein, we investigated the protective effects of polysaccharides from mulberry fruit on diabetic db/db mice. We observed an inhibition in the body weight increase, a decrease in the blood glucose levels, and an improvement in glucose tolerance. Furthermore, our data showed increased enzymatic activities as evidenced by parameters such as superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT). In addition, high density lipoprotein cholesterol (HDL-C) increased, while total cholesterol (TC), triacylglycerol (TG), low density lipoprotein cholesterol (LDL-C), lipid peroxide content malonaldehyde (MDA), and free fatty acid (FFA) levels decreased, accompanied by the recovery from damage to the liver, kidneys and pancreas. Meanwhile, metformin and polysaccharide similarly shifted the abundance of the main gut microbiota, Bacteroidetes and Firmicutes, in diabetic mice toward levels observed in healthy mice. Especially at the genus level, the enrichment of some key bacteria like Bacteroidales, Lactobacillus, Allobaculum, Bacteroides, and Akkermansia was observed. Taken together, our findings suggest that polysaccharides from the mulberry fruit modulate gut microbiota, including enriching functional bacteria and reducing microbial diversity, which may contribute to their antidiabetic effects.
C1 [Chen, Chun; You, Li-Jun; Huang, Qiang; Fu, Xiong; Zhang, Bin; Liu, Rui-Hai; Li, Chao] South China Univ Technol, Sch Food Sci & Engn, 381 Wushan Rd, Guangzhou 510640, Guangdong, Peoples R China.
   [Chen, Chun] Guangdong Prov Key Lab Green Proc Nat Prod & Prod, Guangzhou 510640, Guangdong, Peoples R China.
   [You, Li-Jun; Huang, Qiang; Fu, Xiong; Zhang, Bin; Liu, Rui-Hai; Li, Chao] Overseas Expertise Intro Ctr Discipline Innovat F, Guangzhou, Guangdong, Peoples R China.
   [Liu, Rui-Hai] Cornell Univ, Dept Food Sci, Stocking Hall, Ithaca, NY 14853 USA.
C3 South China University of Technology; Cornell University
RP Fu, X; Zhang, B (通讯作者)，South China Univ Technol, Sch Food Sci & Engn, 381 Wushan Rd, Guangzhou 510640, Guangdong, Peoples R China.; Fu, X; Zhang, B (通讯作者)，Overseas Expertise Intro Ctr Discipline Innovat F, Guangzhou, Guangdong, Peoples R China.
EM lfxfu@scut.edu.cn; zhangb@scut.edu.cn
RI Zhang, Bin/AAC-6655-2020; Liu, Rui Hai/AAE-4865-2019; You,
   Lijun/AAD-7043-2019; Liu, Rui Hai/C-2865-2008; Li, Chao/AAY-2060-2020;
   游, 丽君/Q-4596-2019; , 韦梦汾/AAI-9364-2021
OI Zhang, Bin/0000-0003-4465-4826; Liu, Rui Hai/0000-0002-7018-7929; Li,
   Chao/0000-0003-3863-0289; 游, 丽君/0000-0001-7873-3894; chun,
   chen/0000-0002-2178-1438; ZHANG, BIN/0000-0003-0633-2930
FU 111 Project [B17018]
FX We are grateful for the financial assistance from the 111 Project
   (B17018).
CR Bajzer M, 2006, NATURE, V444, P1009, DOI 10.1038/4441009a
   BAYNES JW, 1991, DIABETES, V40, P405, DOI 10.2337/diabetes.40.4.405
   BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
   Chang CJ, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms8489
   Chen C, 2016, FOOD FUNCT, V7, P4637, DOI [10.1039/c6fo01248e, 10.1039/C6FO01248E]
   Chen C, 2016, FOOD HYDROCOLLOID, V58, P171, DOI 10.1016/j.foodhyd.2016.02.033
   Chen C, 2016, FOOD FUNCT, V7, P530, DOI [10.1039/C5FO01114K, 10.1039/c5fo01114k]
   Cheng N, 2013, FOOD CHEM TOXICOL, V55, P234, DOI 10.1016/j.fct.2012.11.022
   Clemente JC, 2012, CELL, V148, P1258, DOI 10.1016/j.cell.2012.01.035
   Cox LM, 2013, FASEB J, V27, P692, DOI 10.1096/fj.12-219477
   DUBOIS M, 1956, ANAL CHEM, V28, P350, DOI 10.1021/ac60111a017
   Ejtahed HS, 2012, NUTRITION, V28, P539, DOI 10.1016/j.nut.2011.08.013
   Evans CC, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0092193
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Everard A, 2011, DIABETES, V60, P2775, DOI 10.2337/db11-0227
   Fei N, 2013, ISME J, V7, P880, DOI 10.1038/ismej.2012.153
   Friedman JM, 2004, NAT MED, V10, P563, DOI 10.1038/nm0604-563
   Huang M, 2015, CARBOHYD POLYM, V117, P91, DOI 10.1016/j.carbpol.2014.09.008
   Hwang HJ, 2005, LIFE SCI, V76, P3069, DOI 10.1016/j.lfs.2004.12.019
   Jiang CH, 2015, J ETHNOPHARMACOL, V176, P17, DOI 10.1016/j.jep.2015.10.006
   Koren O, 2012, CELL, V150, P470, DOI 10.1016/j.cell.2012.07.008
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Ley RE, 2005, P NATL ACAD SCI USA, V102, P11070, DOI 10.1073/pnas.0504978102
   Ling ZX, 2014, APPL ENVIRON MICROB, V80, P2546, DOI 10.1128/AEM.00003-14
   Liu J, 2010, CARBOHYD POLYM, V82, P1278, DOI 10.1016/j.carbpol.2010.07.008
   Liu Q, 2014, J AGR FOOD CHEM, V62, P8858, DOI 10.1021/jf502632c
   Liu YT, 2013, FOOD CHEM TOXICOL, V57, P39, DOI 10.1016/j.fct.2013.03.001
   Moroti C, 2012, LIPIDS HEALTH DIS, V11, DOI 10.1186/1476-511X-11-29
   Naso D., 2011, EXP DIABETES RES, P1
   Neyrinck AM, 2012, J NUTR BIOCHEM, V23, P51, DOI 10.1016/j.jnutbio.2010.10.008
   Nicholson JK, 2012, SCIENCE, V336, P1262, DOI 10.1126/science.1223813
   O'Connor EM, 2014, P NUTR SOC, V73, P441, DOI 10.1017/S0029665114000597
   Oishi K, 2015, J NUTR, V145, P199, DOI 10.3945/jn.114.202754
   Pan LH, 2014, INT J BIOL MACROMOL, V64, P420, DOI 10.1016/j.ijbiomac.2013.12.024
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Sabir SM, 2012, FOOD CHEM, V131, P741, DOI 10.1016/j.foodchem.2011.09.026
   Schnorr SL, 2014, NAT COMMUN, V5, DOI 10.1038/ncomms4654
   Shaw JE, 2010, DIABETES RES CLIN PR, V87, P4, DOI 10.1016/j.diabres.2009.10.007
   Shoelson SE, 2006, J CLIN INVEST, V116, P1793, DOI 10.1172/JCI29069
   Stein O, 1999, ATHEROSCLEROSIS, V144, P285, DOI 10.1016/S0021-9150(99)00065-9
   Tremaroli V, 2012, NATURE, V489, P242, DOI 10.1038/nature11552
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Turnbaugh PJ, 2009, NATURE, V457, P480, DOI 10.1038/nature07540
   Ussar S, 2015, CELL METAB, V22, P516, DOI 10.1016/j.cmet.2015.07.007
   Walsh CJ, 2014, FEBS LETT, V588, P4120, DOI 10.1016/j.febslet.2014.03.035
   Wang LQ, 2015, CARBOHYD POLYM, V131, P355, DOI 10.1016/j.carbpol.2015.06.016
   Wilson PWF, 1998, CIRCULATION, V97, P1837, DOI 10.1161/01.CIR.97.18.1837
   Xu Y, 2013, JAMA-J AM MED ASSOC, V310, P948, DOI 10.1001/jama.2013.168118
   Yao DC, 2005, FREE RADICAL BIO MED, V39, P1385, DOI 10.1016/j.freeradbiomed.2005.07.015
   Zhang CH, 2010, ISME J, V4, P232, DOI 10.1038/ismej.2009.112
   Zhang HS, 2009, P NATL ACAD SCI USA, V106, P2365, DOI 10.1073/pnas.0812600106
   Zhou SS, 2016, SCI REP-UK, V6, DOI 10.1038/srep22474
NR 52
TC 93
Z9 100
U1 8
U2 234
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD JUL 1
PY 2018
VL 9
IS 7
BP 3732
EP 3742
DI 10.1039/c7fo01346a
PG 11
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA GN7CK
UT WOS:000439280800015
PM 29995048
DA 2023-06-08
ER

PT J
AU Horvath, VJ
   Putz, Z
   Izbeki, F
   Korei, AE
   Gero, L
   Lengyel, C
   Kempler, P
   Varkonyi, T
AF Horvath, Viktor Jozsef
   Putz, Zsuzsanna
   Izbeki, Ferenc
   Korei, Anna Erzsebet
   Gero, Laszlo
   Lengyel, Csaba
   Kempler, Peter
   Varkonyi, Tamas
TI Diabetes-Related Dysfunction of the Small Intestine and the Colon: Focus
   on Motility
SO CURRENT DIABETES REPORTS
LA English
DT Review
DE Diabetes mellitus; Small and large bowel; Enteric nerves; Interstitial
   cells of Cajal; Gut microbiota; Dysfunction
ID ENTERIC NERVOUS-SYSTEM; BOWEL BACTERIAL OVERGROWTH; INTERSTITIAL-CELLS;
   GASTROINTESTINAL SYMPTOMS; AUTONOMIC NEUROPATHY; GUT MICROBIOTA; CAJAL;
   DISORDERS; PATHOPHYSIOLOGY; METFORMIN
AB In contrast to gastric dysfunction, diabetes-related functional impairments of the small and large intestine have been studied less intensively. The gastrointestinal tract accomplishes several functions, such as mixing and propulsion of luminal content, absorption and secretion of ions, water, and nutrients, defense against pathogens, and elimination of waste products. Diverse functions of the gut are regulated by complex interactions among its functional elements, including gut microbiota. The network-forming tissues, the enteric nervous system) and the interstitial cells of Cajal, are definitely impaired in diabetic patients, and their loss of function is closely related to the symptoms in diabetes, but changes of other elements could also play a role in the development of diabetes mellitus-related motility disorders. The development of our understanding over the recent years of the diabetes-induced dysfunctions in the small and large intestine are reviewed in this article.
C1 [Horvath, Viktor Jozsef; Putz, Zsuzsanna; Korei, Anna Erzsebet; Gero, Laszlo; Kempler, Peter] Semmelweis Univ, Dept Med 1, H-1083 Budapest, Hungary.
   [Izbeki, Ferenc] Fejer Megyei Szent Gyorgy Egyet Oktato Korhaz, Szekesfehervar, Hungary.
   [Lengyel, Csaba; Varkonyi, Tamas] Univ Szeged, Dept Med 1, Szeged, Hungary.
C3 Semmelweis University; Szeged University
RP Horvath, VJ (通讯作者)，Semmelweis Univ, Dept Med 1, Koranyi Sandor Utca 2-a, H-1083 Budapest, Hungary.
EM horvathjviktor@gmail.com
RI KÃrei, Anna/V-1068-2019
CR Asano Y, 2012, AM J PHYSIOL-GASTR L, V303, pG1288, DOI 10.1152/ajpgi.00341.2012
   Atkinson MA, 2011, DIABETES, V60, P1370, DOI 10.2337/db10-1797
   Bagyanszki M, 2012, WORLD J DIABETES, V3, P80, DOI 10.4239/wjd.v3.i5.80
   Barbara G, 2005, AM J GASTROENTEROL, V100, P2560, DOI 10.1111/j.1572-0241.2005.00230.x
   Bardsley MR, 2010, GASTROENTEROLOGY, V139, P942, DOI 10.1053/j.gastro.2010.05.083
   Bharucha AE, 2013, GUT, V62, P708, DOI 10.1136/gutjnl-2012-302483
   Blair PJ, 2014, J NEUROGASTROENTEROL, V20, P294, DOI 10.5056/jnm14060
   Bodi N, 2012, MICROCIRCULATION, V19, P316, DOI 10.1111/j.1549-8719.2012.00164.x
   Bravo JA, 2011, P NATL ACAD SCI USA, V108, P16050, DOI 10.1073/pnas.1102999108
   Brock C, 2013, DIABETES CARE, V36, P3698, DOI 10.2337/dc13-0347
   Bytzer P, 2002, AM J GASTROENTEROL, V97, P604
   Bytzer P, 2001, ALIMENT PHARM THER, V15, P137, DOI 10.1046/j.1365-2036.2001.00896.x
   Cesario V, 2014, MINERVA ENDOCRINOL, V39, P201
   Chandrasekharan B, 2011, NEUROGASTROENT MOTIL, V23, DOI 10.1111/j.1365-2982.2010.01611.x
   Dave M, 2015, GASTROENTEROLOGY, V148, P978, DOI 10.1053/j.gastro.2015.01.036
   El-Salhy M, 2002, HISTOL HISTOPATHOL, V17, P1153, DOI 10.14670/HH-17.1153
   FELDMAN M, 1983, ANN INTERN MED, V98, P378, DOI 10.7326/0003-4819-98-3-378
   Forrest A, 2008, AM J PHYSIOL-GASTR L, V294, pG315, DOI 10.1152/ajpgi.00196.2007
   Furness JB, 2014, ADV EXP MED BIOL, V817, P39, DOI 10.1007/978-1-4939-0897-4_3
   Gatopoulou A, 2012, EUR J INTERN MED, V23, P499, DOI 10.1016/j.ejim.2012.03.001
   GREENBERG GR, 1994, PANCREAS, V9, P531, DOI 10.1097/00006676-199407000-00018
   Gutierrez-Canas I, 2006, RHEUMATOLOGY, V45, P527, DOI 10.1093/rheumatology/kei219
   He CL, 2001, GASTROENTEROLOGY, V121, P427, DOI 10.1053/gast.2001.26264
   Holst JJ, 2011, CURR MED RES OPIN, V27, P547, DOI 10.1185/03007995.2010.549466
   Horvath VJ, 2015, CURR DIABETES REP, V15, DOI 10.1007/s11892-014-0527-8
   Huizinga JD, 2014, NAT COMMUN, V5, DOI 10.1038/ncomms4326
   Huizinga JD, 2011, FRONT NEUROSCI-SWITZ, V5, DOI 10.3389/fnins.2011.00093
   Huizinga JD, 2009, GASTROENTEROLOGY, V137, P1548, DOI 10.1053/j.gastro.2009.09.023
   Imaeda Kenro, 1998, Journal of Smooth Muscle Research, V34, P1
   Iyer LM, 2004, TRENDS GENET, V20, P292, DOI 10.1016/j.tig.2004.05.007
   Izbeki F, 2008, DIABETES RES CLIN PR, V80, P192, DOI 10.1016/j.diabres.2007.12.013
   JANATUINEN E, 1993, SCAND J GASTROENTERO, V28, P427, DOI 10.3109/00365529309098244
   Jung HK, 2003, YONSEI MED J, V44, P265, DOI 10.3349/ymj.2003.44.2.265
   KAWANO K, 1992, DIABETES, V41, P1422, DOI 10.2337/diabetes.41.11.1422
   Kazakos KA, 2008, MED SCI MONITOR, V14, pCR213
   Kempler P, 2011, DIABETES-METAB RES, V27, P665, DOI 10.1002/dmrr.1223
   Kim SJ, 2011, J NEUROGASTROENTEROL, V17, P372, DOI 10.5056/jnm.2011.17.4.372
   Kunze WA, 2009, J CELL MOL MED, V13, P2261, DOI 10.1111/j.1582-4934.2009.00686.x
   Lammers WJEP, 2011, EXP PHYSIOL, V96, P1039, DOI 10.1113/expphysiol.2011.058941
   Landman GWD, 2010, DIABETES CARE, V33, P322, DOI 10.2337/dc09-1380
   Lelic D, 2014, NEUROGASTROENT MOTIL, V26, P46, DOI 10.1111/nmo.12222
   Lelic D, 2013, NEUROSCIENCE, V237, P96, DOI 10.1016/j.neuroscience.2013.01.049
   Lorincz A, 2008, GASTROENTEROLOGY, V134, P1083, DOI 10.1053/j.gastro.2008.01.036
   LUNDGREN O, 1989, DIGEST DIS SCI, V34, P264, DOI 10.1007/BF01536062
   MAXTON DG, 1991, POSTGRAD MED J, V67, P991, DOI 10.1136/pgmj.67.793.991
   MOURAD FH, 1992, GUT, V33, P1578, DOI 10.1136/gut.33.11.1578
   Nakahara M, 2002, J GASTROEN HEPATOL, V17, P666, DOI 10.1046/j.1440-1746.2002.02756.x
   Nguyen LA, 2015, GASTROENTEROL CLIN N, V44, P21, DOI 10.1016/j.gtc.2014.11.003
   Nielsen DS, 2014, FEBS LETT, V588, P4234, DOI 10.1016/j.febslet.2014.04.010
   Noto H, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0033411
   Ordog T, 2008, NEUROGASTROENT MOTIL, V20, P8, DOI 10.1111/j.1365-2982.2007.01056.x
   Ojetti V, 2009, EUR REV MED PHARMACO, V13, P419
   Pappachan JM, 2015, WORLD J DIABETES, V6, P774, DOI 10.4239/wjd.v6.i6.774
   Phillips Liza K, 2006, Curr Diab Rep, V6, P417, DOI 10.1007/s11892-006-0073-0
   Quan C, 2003, ALIMENT PHARM THER, V17, P1179, DOI 10.1046/j.1365-2036.2003.01553.x
   Rhee SH, 2009, NAT REV GASTRO HEPAT, V6, P306, DOI 10.1038/nrgastro.2009.35
   Rosztoczy A, 2004, Z GASTROENTEROL, V42, P1295, DOI 10.1055/s-2004-813618
   Ruiter R, 2012, DIABETES CARE, V35, P119, DOI 10.2337/dc11-0857
   Samsom M, 1996, DIABETES CARE, V19, P21, DOI 10.2337/diacare.19.1.21
   Sanders KM, 2002, AM J PHYSIOL-GASTR L, V282, pG747, DOI 10.1152/ajpgi.00362.2001
   Schicho R, 2006, GASTROENTEROLOGY, V131, P1542, DOI 10.1053/j.gastro.2006.08.035
   Schvarcz E, 1996, DIABETIC MED, V13, P478
   SJOLUND K, 1983, GASTROENTEROLOGY, V85, P1120
   Sobko T, 2006, FREE RADICAL BIO MED, V41, P985, DOI 10.1016/j.freeradbiomed.2006.06.020
   Softeland E, 2014, J DIABETES RES, V2014, DOI 10.1155/2014/784841
   Softeland E, 2014, J DIABETES COMPLICAT, V28, P370, DOI 10.1016/j.jdiacomp.2013.10.009
   TALLEY NJ, 1989, ANN INTERN MED, V111, P671, DOI 10.7326/0003-4819-111-8-671
   Vaarala O, 2008, DIABETES, V57, P2555, DOI 10.2337/db08-0331
   Vaarala O, 2013, CURR DIABETES REP, V13, P601, DOI 10.1007/s11892-013-0409-5
   VALDOVINOS MA, 1993, MAYO CLIN PROC, V68, P691, DOI 10.1016/S0025-6196(12)60606-5
   VONDEROHE MR, 1995, EUR J GASTROEN HEPAT, V7, P730
   WALD A, 1995, EUR J GASTROEN HEPAT, V7, P737
   Wheway J, 2005, J EXP MED, V202, P1527, DOI 10.1084/jem.20051971
   Wirth R, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0110440
   Yamamoto T, 2006, GASTROENTEROLOGY, V130, pA90
   Yarandi SS, 2014, NEUROGASTROENT MOTIL, V26, P611, DOI 10.1111/nmo.12330
   Zhang ZJ, 2011, DIABETES CARE, V34, P2323, DOI 10.2337/dc11-0512
   Zietz B, 2000, DIABETES CARE, V23, P1200, DOI 10.2337/diacare.23.8.1200
NR 78
TC 23
Z9 23
U1 0
U2 23
PU CURRENT MEDICINE GROUP
PI PHILADELPHIA
PA 400 MARKET STREET, STE 700, PHILADELPHIA, PA 19106 USA
SN 1534-4827
EI 1539-0829
J9 CURR DIABETES REP
JI Curr. Diabetes Rep.
PD NOV
PY 2015
VL 15
IS 11
AR 94
DI 10.1007/s11892-015-0672-8
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CT7WP
UT WOS:000363025700018
PM 26374571
DA 2023-06-08
ER

PT J
AU Xu, RL
   Zhang, YX
   Chen, SR
   Zeng, YH
   Fu, X
   Chen, T
   Luo, SL
   Zhang, XJ
AF Xu, Ruiling
   Zhang, Yuxuan
   Chen, Shurui
   Zeng, Yaohui
   Fu, Xuan
   Chen, Ti
   Luo, Shilin
   Zhang, Xiaojie
TI The role of the probiotic Akkermansia muciniphila in brain functions:
   insights underpinning therapeutic potential
SO CRITICAL REVIEWS IN MICROBIOLOGY
LA English
DT Review
DE Akkermansia muciniphila; probiotic; neuropsychiatric disorders;
   gut-brain axis; therapeutic target
ID CHAIN FATTY-ACIDS; GUT MICROBIOTA; PARKINSONS-DISEASE; INTESTINAL
   MICROBIOTA; AUTISM; MUCIN; BACTERIA; METFORMIN; CHILDREN; HEALTH
AB The role of Akkermansia muciniphila, one of the most abundant microorganisms of the intestinal microbiota, has been studied extensively in metabolic diseases, such as obesity and diabetes. It is considered a next-generation probiotic microorganism. Although its mechanism of action has not been fully elucidated, accumulating evidence indicates the important role of A. muciniphila in brain functions via the gut-brain axis and its potential as a therapeutic target in various neuropsychiatric disorders. However, only a limited number of studies, particularly clinical studies, have directly assessed the therapeutic effects of A. muciniphila interventions in these disorders. This is the first review to discuss the comprehensive mechanism of A. muciniphila in the gut-brain axis via the protection of the intestinal mucosal barrier and modulation of the immune system and metabolites, such as short-chain fatty acids, amino acids, and amino acid derivatives. Additionally, the role of A. muciniphila and its therapeutic potential in various neuropsychiatric disorders, including Alzheimer's disease and cognitive deficit, amyotrophic lateral sclerosis, Parkinson's disease, and multiple sclerosis, have been discussed. The review suggests the potential role of A. muciniphila in healthy brain functions.
C1 [Xu, Ruiling; Zhang, Yuxuan; Chen, Shurui; Zeng, Yaohui; Fu, Xuan; Zhang, Xiaojie] Cent South Univ, Xiangya Hosp 2, Dept Psychiat, Changsha, Hunan, Peoples R China.
   [Xu, Ruiling; Zhang, Yuxuan; Chen, Shurui; Zeng, Yaohui; Fu, Xuan; Zhang, Xiaojie] Natl Clin Res Ctr Mental Disorders, Changsha, Hunan, Peoples R China.
   [Xu, Ruiling; Zhang, Yuxuan; Chen, Shurui; Zeng, Yaohui; Fu, Xuan; Zhang, Xiaojie] Natl Technol Inst Mental Disorders, Changsha, Hunan, Peoples R China.
   [Xu, Ruiling; Zhang, Yuxuan; Chen, Shurui; Zeng, Yaohui; Fu, Xuan; Zhang, Xiaojie] Hunan Key Lab Psychiat & Mental Hlth, Changsha, Hunan, Peoples R China.
   [Xu, Ruiling; Zhang, Yuxuan; Chen, Shurui; Zeng, Yaohui; Fu, Xuan; Zhang, Xiaojie] Cent South Univ, Xiangya Hosp 2, Mental Hlth Inst, Changsha, Hunan, Peoples R China.
   [Chen, Ti] Cent South Univ, Xiangya Hosp 3, Clin Lab, Changsha, Hunan, Peoples R China.
   [Luo, Shilin] Cent South Univ, Xiangya Hosp 2, Dept Pharm, Changsha, Hunan, Peoples R China.
C3 Central South University; Central South University; Central South
   University; Central South University
RP Zhang, XJ (通讯作者)，Cent South Univ, Xiangya Hosp 2, Dept Psychiat, Changsha, Hunan, Peoples R China.
EM xiaojiezhang2014@csu.edu.cn
RI zeng, yaohui/HLX-1681-2023
OI Luo, shilin/0000-0002-6773-7790; Xu, Ruiling/0000-0002-7205-0459; zhang,
   xiaojie/0000-0002-6211-7576
FU Hunan Provincial Natural Science Foundation [2021JJ40894]; Changsha
   Natural Science Foundation [kq2014239]; Scientific Research Project of
   Hunan Provincial Health Commission [202211004855, 202103090528]; Central
   South University Undergraduate Research and Innovation (URI) Program
   [S2020105330520]
FX This work was supported by the Hunan Provincial Natural Science
   Foundation (2021JJ40894), Changsha Natural Science Foundation Project
   (kq2014239) and Scientific Research Project of Hunan Provincial Health
   Commission 202103090528 for X.Z., Scientific Research Project of Hunan
   Provincial Health Commission 202211004855 for T.C. Central South
   University Undergraduate Research and Innovation (URI) Program
   S2020105330520 for R.X.
CR Aakko J, 2017, BENEF MICROBES, V8, P563, DOI 10.3920/BM2016.0185
   Aatsinki AK, 2020, PSYCHONEUROENDOCRINO, V119, DOI 10.1016/j.psyneuen.2020.104754
   Addolorato G, 2020, LIVER INT, V40, P878, DOI 10.1111/liv.14383
   Al-Ghezi ZZ, 2019, BRAIN BEHAV IMMUN, V82, P25, DOI 10.1016/j.bbi.2019.07.028
   Alberdi A, 2022, NAT REV GENET, V23, P281, DOI 10.1038/s41576-021-00421-0
   Anderson JR, 2017, SLEEP MED, V38, P104, DOI 10.1016/j.sleep.2017.07.018
   Anhe FF, 2017, MOL METAB, V6, P1563, DOI 10.1016/j.molmet.2017.10.003
   Badal VD, 2020, NUTRIENTS, V12, DOI 10.3390/nu12123759
   Baldini F, 2020, BMC BIOL, V18, DOI 10.1186/s12915-020-00775-7
   Bana B, 2019, ANNU REV GENET, V53, P239, DOI 10.1146/annurev-genet-112618-043650
   Barcena C, 2019, NAT MED, V25, P1234, DOI 10.1038/s41591-019-0504-5
   Barichella M, 2019, MOVEMENT DISORD, V34, P396, DOI 10.1002/mds.27581
   Basolo A, 2020, NAT MED, V26, P589, DOI 10.1038/s41591-020-0801-z
   Baxter NT, 2014, MICROBIOME, V2, DOI 10.1186/2049-2618-2-20
   Bedarf JR, 2017, GENOME MED, V9, DOI 10.1186/s13073-017-0428-y
   Belzer C, 2012, ISME J, V6, P1449, DOI 10.1038/ismej.2012.6
   Berer K, 2017, P NATL ACAD SCI USA, V114, P10719, DOI 10.1073/pnas.1711233114
   Biagi E, 2016, CURR BIOL, V26, P1480, DOI 10.1016/j.cub.2016.04.016
   Bian XY, 2019, FRONT MICROBIOL, V10, DOI 10.3389/fmicb.2019.02259
   Blacher E, 2019, NATURE, V572, P474, DOI 10.1038/s41586-019-1443-5
   Bressa C, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0171352
   Bulgart HR, 2020, MOL NEURODEGENER, V15, DOI 10.1186/s13024-020-00378-4
   Burokas A, 2017, BIOL PSYCHIAT, V82, P472, DOI 10.1016/j.biopsych.2016.12.031
   Collado MC, 2012, PEDIATR RES, V72, P77, DOI 10.1038/pr.2012.42
   Carmody RN, 2015, CELL HOST MICROBE, V17, P72, DOI 10.1016/j.chom.2014.11.010
   Cekanaviciute E, 2017, P NATL ACAD SCI USA, V114, P10713, DOI 10.1073/pnas.1711235114
   Chaidez V, 2014, J AUTISM DEV DISORD, V44, P1117, DOI 10.1007/s10803-013-1973-x
   Chang Y, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-90463-5
   Chelakkot C, 2018, EXP MOL MED, V50, DOI 10.1038/emm.2017.282
   Chen RZ, 2019, J NUTR BIOCHEM, V65, P101, DOI 10.1016/j.jnutbio.2018.12.004
   Chen YJ, 2020, BIOMED RES INT, V2020, DOI 10.1155/2020/8456596
   Chu C., 2019, MICROBIOTA REGULATE
   Collado MC, 2007, APPL ENVIRON MICROB, V73, P7767, DOI 10.1128/AEM.01477-07
   Cox LM, 2021, ANN NEUROL, V89, P1195, DOI 10.1002/ana.26084
   Cox LM, 2014, CELL, V158, P705, DOI 10.1016/j.cell.2014.05.052
   Cryan JF, 2012, NAT REV NEUROSCI, V13, P701, DOI 10.1038/nrn3346
   Davidson GL, 2018, PHILOS T R SOC B, V373, DOI 10.1098/rstb.2017.0286
   De Angelis M, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0076993
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Demirci M, 2019, ALLERGOL IMMUNOPATH, V47, P365, DOI 10.1016/j.aller.2018.12.009
   Derosa L, 2022, NAT MED, V28, P315, DOI 10.1038/s41591-021-01655-5
   Derrien M, 2004, INT J SYST EVOL MICR, V54, P1469, DOI 10.1099/ijs.0.02873-0
   Derrien M, 2008, APPL ENVIRON MICROB, V74, P1646, DOI 10.1128/AEM.01226-07
   Ding Y, 2021, APPL MICROBIOL BIOT, V105, P8411, DOI 10.1007/s00253-021-11622-2
   Dodiya HB, 2020, NEUROBIOL DIS, V135, DOI 10.1016/j.nbd.2018.12.012
   Doifode T, 2021, PHARMACOL RES, V164, DOI 10.1016/j.phrs.2020.105314
   Dooling SW, 2018, CELL HOST MICROBE, V24, P3, DOI 10.1016/j.chom.2018.06.014
   Drucker DJ, 2001, J CLIN ENDOCR METAB, V86, P1759, DOI 10.1210/jc.86.4.1759
   Earley H, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-51878-3
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Everard A, 2011, DIABETES, V60, P2775, DOI 10.2337/db11-0227
   Fak F, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0127252
   Fang X., 2020, THERAPEUTIC EFFECT G
   Farr SA, 2019, J ALZHEIMERS DIS, V68, P1699, DOI 10.3233/JAD-181240
   Finegold SM, 2008, MED HYPOTHESES, V70, P508, DOI 10.1016/j.mehy.2007.07.019
   Finegold SM, 2011, ANAEROBE, V17, P367, DOI 10.1016/j.anaerobe.2011.03.007
   Finegold SM, 2010, ANAEROBE, V16, P444, DOI 10.1016/j.anaerobe.2010.06.008
   Foster JA, 2013, TRENDS NEUROSCI, V36, P305, DOI 10.1016/j.tins.2013.01.005
   Fransen F, 2017, FRONT IMMUNOL, V8, DOI 10.3389/fimmu.2017.01385
   Ganesh BP, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0074963
   Geerlings SY, 2018, MICROORGANISMS, V6, DOI 10.3390/microorganisms6030075
   Gorecki AM, 2019, FRONT NEUROSCI-SWITZ, V13, DOI 10.3389/fnins.2019.00839
   Goswami C, 2018, J NUTR BIOCHEM, V57, P130, DOI 10.1016/j.jnutbio.2018.03.009
   Gotkine M, 2020, GUT MICROBES, V11, P1833, DOI 10.1080/19490976.2020.1767464
   Grander C, 2018, GUT, V67, P892, DOI 10.1136/gutjnl-2016-313432
   Gu ZY, 2021, FOOD FUNCT, V12, P10184, DOI [10.1039/D1FO02172A, 10.1039/d1fo02172a]
   Guevara-Cruz M, 2019, J AM HEART ASSOC, V8, DOI 10.1161/JAHA.119.012401
   Guo X, 2016, J APPL MICROBIOL, V120, P452, DOI 10.1111/jam.13022
   Hanninen A, 2018, GUT, V67, P1445, DOI 10.1136/gutjnl-2017-314508
   Hansen CHF, 2012, DIABETOLOGIA, V55, P2285, DOI 10.1007/s00125-012-2564-7
   Heintz-Buschart A, 2018, MOVEMENT DISORD, V33, P88, DOI 10.1002/mds.27105
   Higarza SG, 2021, GUT MICROBES, V13, P1, DOI 10.1080/19490976.2021.1880240
   Hill-Burns EM, 2017, MOVEMENT DISORD, V32, P739, DOI 10.1002/mds.26942
   Hou YF, 2021, MICROBIOME, V9, DOI 10.1186/s40168-020-00988-6
   Huang CF, 2019, FRONT PEDIATR, V7, DOI 10.3389/fped.2019.00394
   Huck O, 2020, J CLIN PERIODONTOL, V47, P202, DOI 10.1111/jcpe.13214
   Inoue R, 2016, BIOSCI BIOTECH BIOCH, V80, P2450, DOI 10.1080/09168451.2016.1222267
   Jackson PA, 2012, BRIT J NUTR, V107, P1093, DOI 10.1017/S0007114511004041
   Jangi S, 2016, NAT COMMUN, V7, DOI 10.1038/ncomms12015
   Jeon H, 2021, BRAIN BEHAV IMMUN, V94, P410, DOI 10.1016/j.bbi.2021.02.028
   Ji SQ, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00704
   Jiang CM, 2017, J ALZHEIMERS DIS, V58, P1, DOI 10.3233/JAD-161141
   Joseph Jamie, 2017, Front Neurosci, V11, P155, DOI 10.3389/fnins.2017.00155
   Kang CS, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0076520
   Kang DW, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0068322
   Karlsson CLJ, 2012, OBESITY, V20, P2257, DOI 10.1038/oby.2012.110
   Keshavarzian A, 2015, MOVEMENT DISORD, V30, P1351, DOI 10.1002/mds.26307
   Kim BS, 2019, J MICROBIOL BIOTECHN, V29, P429, DOI 10.4014/jmb.1811.11023
   Kong FL, 2016, CURR BIOL, V26, pR832, DOI 10.1016/j.cub.2016.08.015
   Lee Y, 2017, EXP NEUROBIOL, V26, P307, DOI 10.5607/en.2017.26.5.307
   Li CX, 2019, FRONT MOL NEUROSCI, V12, DOI 10.3389/fnmol.2019.00171
   Li N, 2019, BMC MICROBIOL, V19, DOI 10.1186/s12866-019-1552-1
   Lin AQ, 2018, PARKINSONISM RELAT D, V53, P82, DOI 10.1016/j.parkreldis.2018.05.007
   Lin CH, 2019, J NEUROINFLAMM, V16, DOI 10.1186/s12974-019-1528-y
   Liu ZH, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.01687
   Lowe PP, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0174544
   Lu XY, 2020, OXID MED CELL LONGEV, V2020, DOI 10.1155/2020/2315106
   Lukovac S, 2014, MBIO, V5, DOI 10.1128/mBio.01438-14
   Luna E, 2015, FEBS LETT, V589, P3749, DOI 10.1016/j.febslet.2015.10.023
   Lv WJ, 2020, OXID MED CELL LONGEV, V2020, DOI 10.1155/2020/1241894
   Ma D, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-25190-5
   Manderino L, 2017, J INT NEUROPSYCH SOC, V23, P700, DOI 10.1017/S1355617717000492
   Mcgaughey, 2019, RELATIVE ABUNDANCE A
   Meckel KR, 2019, PSYCHOPHARMACOLOGY, V236, P1513, DOI 10.1007/s00213-019-05232-0
   Meireles M, 2016, FOOD FUNCT, V7, P127, DOI [10.1039/c5fo00925a, 10.1039/C5FO00925A]
   Nagpal R, 2019, EBIOMEDICINE, V47, P529, DOI 10.1016/j.ebiom.2019.08.032
   Naito Y, 2018, J CLIN BIOCHEM NUTR, V63, P33, DOI 10.3164/jcbn.18-57
   Neth BJ, 2020, NEUROBIOL AGING, V86, P54, DOI 10.1016/j.neurobiolaging.2019.09.015
   Newell C, 2016, MOL AUTISM, V7, DOI 10.1186/s13229-016-0099-3
   Nichols RG, 2021, HUM GENET, V140, P747, DOI 10.1007/s00439-020-02237-0
   Nishiwaki H, 2020, MOVEMENT DISORD, V35, P1626, DOI 10.1002/mds.28119
   Nobel YR, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms8486
   Olson CA, 2018, CELL, V174, P497, DOI 10.1016/j.cell.2018.06.051
   Ottman N.A., 2015, HOST IMMUNOSTIMULATI
   Ottman N, 2017, BEST PRACT RES CL GA, V31, P637, DOI 10.1016/j.bpg.2017.10.001
   Ottman N, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0173004
   Ou ZR, 2018, BRAIN BEHAV IMMUN, V69, P351, DOI 10.1016/j.bbi.2017.12.009
   Ou ZH, 2020, NUTR DIABETES, V10, DOI 10.1038/s41387-020-0115-8
   Park S, 2019, EXP BIOL MED, V244, P1629, DOI 10.1177/1535370219889319
   Park YS, 2020, INTEST RES, V18, P325, DOI 10.5217/ir.2019.00093
   Pietrucci D, 2020, BRAIN SCI, V10, DOI 10.3390/brainsci10040242
   Pietrucci D, 2019, PARKINSONISM RELAT D, V65, P124, DOI 10.1016/j.parkreldis.2019.06.003
   Plovier H, 2017, NAT MED, V23, P107, DOI 10.1038/nm.4236
   Png CW, 2010, AM J GASTROENTEROL, V105, P2420, DOI 10.1038/ajg.2010.281
   Rabe-Jablonska J, 1994, Psychiatr Pol, V28, P255
   Reunanen J, 2015, APPL ENVIRON MICROB, V81, P3655, DOI 10.1128/AEM.04050-14
   Rodakis John, 2015, Microbial Ecology in Health and Disease, V26, P26382, DOI 10.3402/mehd.v26.26382
   Romano S, 2021, NPJ PARKINSONS DIS, V7, DOI 10.1038/s41531-021-00156-z
   Routy B, 2018, SCIENCE, V359, P91, DOI 10.1126/science.aan3706
   Salazar N., 2021, BIOGERONTOLOGY, V2021, P43
   Sandler RH, 2000, J CHILD NEUROL, V15, P429, DOI 10.1177/088307380001500701
   Scheperjans F, 2015, MOVEMENT DISORD, V30, P350, DOI 10.1002/mds.26069
   Seregin SS, 2017, CELL REP, V19, P2174, DOI 10.1016/j.celrep.2017.05.074
   Sharon G, 2019, CELL, V177, P1600, DOI 10.1016/j.cell.2019.05.004
   Shen T, 2021, FRONT AGING NEUROSCI, V13, DOI 10.3389/fnagi.2021.636545
   Shin J, 2021, MICROBIOME, V9, DOI 10.1186/s40168-021-01189-5
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Shukla D, 2018, INDIAN J PHARMACOL, V50, P227, DOI 10.4103/ijp.IJP_74_17
   Singh H, 2019, GEROSCIENCE, V41, P907, DOI 10.1007/s11357-019-00098-8
   Song J, 2019, J TRANSL MED, V17, DOI 10.1186/s12967-019-1970-8
   Stanley D, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-017-18904-8
   Strati F, 2017, MICROBIOME, V5, DOI 10.1186/s40168-017-0242-1
   Swidsinski A, 2011, GUT, V60, P34, DOI 10.1136/gut.2009.191320
   Syal C, 2020, THERANOSTICS, V10, P6337, DOI 10.7150/thno.44962
   Tan J, 2014, ADV IMMUNOL, V121, P91, DOI 10.1016/B978-0-12-800100-4.00003-9
   Tankou SK, 2018, ANN NEUROL, V83, P1147, DOI 10.1002/ana.25244
   Teixeira TFS, 2013, CLIN NUTR, V32, P1017, DOI 10.1016/j.clnu.2013.02.008
   Tung TH, 2019, BIOMOLECULES, V9, DOI 10.3390/biom9100516
   Unger MM, 2016, PARKINSONISM RELAT D, V32, P66, DOI 10.1016/j.parkreldis.2016.08.019
   van der Lugt B, 2019, IMMUN AGEING, V16, DOI 10.1186/s12979-019-0145-z
   Van Herreweghen F, 2017, BENEF MICROBES, V8, P81, DOI 10.3920/BM2016.0013
   Vidal-Martinez G, 2020, J PARKINSON DIS, V10, P185, DOI 10.3233/JPD-191693
   Vitale M, 2021, CLIN NUTR, V40, P428, DOI 10.1016/j.clnu.2020.05.025
   WAKABAYASHI K, 1990, ACTA NEUROPATHOL, V79, P581, DOI 10.1007/BF00294234
   Waldecker M, 2008, J NUTR BIOCHEM, V19, P587, DOI 10.1016/j.jnutbio.2007.08.002
   Wallen ZD, 2020, NPJ PARKINSONS DIS, V6, DOI 10.1038/s41531-020-0112-6
   Wang JC, 2021, FOOD FUNCT, V12, P3597, DOI [10.1039/D1FO00115A, 10.1039/d1fo00115a]
   Wang LJ, 2020, GUT, V69, P1988, DOI 10.1136/gutjnl-2019-320105
   Wang L, 2011, APPL ENVIRON MICROB, V77, P6718, DOI 10.1128/AEM.05212-11
   Wang YL, 2020, FRONT CELL NEUROSCI, V14, DOI 10.3389/fncel.2020.00170
   Wong ML, 2016, MOL PSYCHIATR, V21, P797, DOI 10.1038/mp.2016.46
   Wu CY, 2020, ALZHEIMERS DEMENT, V16, P1663, DOI 10.1002/alz.12161
   Wu FF, 2020, ANAEROBE, V61, DOI 10.1016/j.anaerobe.2019.102138
   Wu WR, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.01804
   Xiang L, 2020, FRONT CELL INFECT MI, V10, DOI 10.3389/fcimb.2020.587284
   Xu MY, 2019, FRONT PSYCHIATRY, V10, DOI 10.3389/fpsyt.2019.00473
   Yan J, 2021, GUT MICROBES, V13, DOI 10.1080/19490976.2021.1984104
   Yang C, 2021, ADDICT BIOL, V26, DOI 10.1111/adb.12975
   Yang YJ, 2019, NEUROPSYCHOPHARMACOL, V44, P2054, DOI 10.1038/s41386-019-0437-1
   Ye FQ, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0150519
   Yoon HS, 2021, NAT MICROBIOL, V6, P563, DOI 10.1038/s41564-021-00880-5
   Zhai QX, 2019, CRIT REV FOOD SCI, V59, P3227, DOI 10.1080/10408398.2018.1517725
   Zhai R, 2019, FRONT CELL INFECT MI, V9, DOI 10.3389/fcimb.2019.00239
   Zhang HS, 2015, ISME J, V9, P770, DOI 10.1038/ismej.2014.165
   Zhang L, 2019, P NATL ACAD SCI USA, V116, P13523, DOI 10.1073/pnas.1901182116
   Zhang T, 2019, MICROB BIOTECHNOL, V12, P1109, DOI 10.1111/1751-7915.13410
   Zou R, 2020, AUTISM RES, V13, P1614, DOI 10.1002/aur.2358
NR 177
TC 11
Z9 11
U1 22
U2 79
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1040-841X
EI 1549-7828
J9 CRIT REV MICROBIOL
JI Crit. Rev. Microbiol.
PD MAR 4
PY 2023
VL 49
IS 2
BP 151
EP 176
DI 10.1080/1040841X.2022.2044286
EA MAR 2022
PG 26
WC Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology
GA 8Z5WU
UT WOS:000767614400001
PM 35272549
OA hybrid
DA 2023-06-08
ER

PT J
AU Bock, PM
   Martins, AF
   Ramalho, R
   Telo, GH
   Leivas, G
   Maraschin, CK
   Schaan, BD
AF Bock, Patricia M.
   Martins, Andreza F.
   Ramalho, Rafaela
   Telo, Gabriela H.
   Leivas, Gabriel
   Maraschin, Clara K.
   Schaan, Beatriz D.
TI The impact of dietary, surgical, and pharmacological interventions on
   gut microbiota in individuals with diabetes mellitus: A systematic
   review
SO DIABETES RESEARCH AND CLINICAL PRACTICE
LA English
DT Review
DE Diabetes mellitus; Lactobacillus; Microbiota
ID AKKERMANSIA-MUCINIPHILA; INTESTINAL MICROBIOTA; METABOLIC IMPROVEMENT;
   BARIATRIC SURGERY; GASTRIC BYPASS; OBESE-PATIENTS; DOUBLE-BLIND; TYPE-2;
   METFORMIN; MODULATION
AB Aims: To conduct a systematic review assessing the association between dietary, surgical, and pharmacological interventions and changes in the gut micmbiota of individuals with diabetes.
   Methods: The MEDLINE, EMBASE, and Cochrane Library databases were searched focusing on the effects of dietary, bariatric surgery, and pharmacological interventions on gut microbiota in adults with diabetes. Studies were classified based on qualitative changes using a simple vote-counting method, evaluating reduction, no effect, or an increase in the gut microbiota outcomes.
   Results: 6,004 studies were retained to review their titles and abstracts. A total of 149 full-text articles were reassessed, of which 49 were included in the final analysis. This review indicates that dietary, surgical, and pharmacological interventions increase or decrease bacterial populations from more than 60 families, genera, or species. In general, the interventions led to an increase in the bacterial population from phylum Firmicutes, mainly Lactobacillus species, compared to the gram-negative bacterial population from phylum Bacteroidetes.
   Conclusions: The results of the included studies suggest that interventions aimed at reducing species related to uncontrolled diabetes and increasing species related to the healthy gut are potential adjuvants in treating diabetes; however, well-conducted interventional studies targeting gut micmbiota are necessary.
C1 [Bock, Patricia M.; Leivas, Gabriel; Maraschin, Clara K.; Schaan, Beatriz D.] Univ Fed Rio Grande do Sul, Fac Med, Dept Internal Med, Grad Program Med Sci Endocrinol, Porto Alegre, RS, Brazil.
   [Bock, Patricia M.] Fac Integradas Taquara, Taquara, Brazil.
   [Bock, Patricia M.; Schaan, Beatriz D.] Hosp Clin Porto Alegre, Natl Inst Sci & Technol Hlth Technol Assessment I, Porto Alegre, RS, Brazil.
   [Martins, Andreza F.; Ramalho, Rafaela] Univ Fed Rio Grande do Sul, Dept Microbiol Immunol & Parasitol, Porto Alegre, RS, Brazil.
   [Telo, Gabriela H.] Pontificia Univ Catolica Rio Grande do Sul, Sch Med, Internal Med Div, Porto Alegre, RS, Brazil.
   [Schaan, Beatriz D.] Hosp Clin Porto Alegre, Endocrine Div, Porto Alegre, RS, Brazil.
C3 Universidade Federal do Rio Grande do Sul; Universidade Federal do Rio
   Grande do Sul; Pontificia Universidade Catolica Do Rio Grande Do Sul
RP Bock, PM (通讯作者)，Hosp Clin Porto Alegre, Rua Ramiro Barcelos 2350, BR-90035003 Porto Alegre, RS, Brazil.
EM patriciabock@faccat.br
RI Bock, Patricia Martins/H-6439-2016
OI Bock, Patricia Martins/0000-0001-8572-3950
FU Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior, Brasil
   (CAPES) [001]
FX This work was supported by the Coordenac ~ao de Aperfeicoamento de
   Pessoal de Nivel Superior, Brasil (CAPES), Finance Code 001. AFM is
   research fellow of the National Council for Scientific and Technological
   Development (CNPq), Ministry of Science and Technology, Brazil.
CR Adak A, 2019, CELL MOL LIFE SCI, V76, P473, DOI 10.1007/s00018-018-2943-4
   Al Assal K, 2020, NUTRIENTS, V12, DOI 10.3390/nu12020278
   Allin KH, 2018, DIABETOLOGIA, V61, P810, DOI 10.1007/s00125-018-4550-1
   Baldelli V, 2021, MICROORGANISMS, V9, DOI 10.3390/microorganisms9040697
   Balfego M, 2016, LIPIDS HEALTH DIS, V15, DOI 10.1186/s12944-016-0245-0
   Bharti R, 2021, BRIEF BIOINFORM, V22, P178, DOI 10.1093/bib/bbz155
   Birkeland E, 2020, EUR J NUTR, V59, P3325, DOI 10.1007/s00394-020-02282-5
   Bock PM, 2021, DIABETOLOGIA, V64, P26, DOI 10.1007/s00125-020-05295-1
   Campbell M, 2020, BMJ-BRIT MED J, V368, DOI 10.1136/bmj.l6890
   Candela M, 2016, BRIT J NUTR, V116, P80, DOI 10.1017/S0007114516001045
   Chelakkot C, 2018, EXP MOL MED, V50, DOI 10.1038/emm.2017.282
   Chen H, 2017, AM J TRANSL RES, V9, P1243
   Cheng YW, 2020, FRONT IMMUNOL, V11, DOI 10.3389/fimmu.2020.615056
   Cortez RV, 2018, SURG OBES RELAT DIS, V14, P1748, DOI 10.1016/j.soard.2018.07.021
   Davies N, 2020, OBES SURG, V30, P3536, DOI 10.1007/s11695-020-04684-0
   Davies NK, 2019, SURG OBES RELAT DIS, V15, P656, DOI 10.1016/j.soard.2019.01.033
   de Jonge C, 2019, INT J OBESITY, V43, P2509, DOI 10.1038/s41366-019-0336-x
   Elbere I, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0241338
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Ferrari F, 2019, ARQ BRAS CARDIOL, V113, P1139, DOI 10.5935/abc.20190224
   Frost F, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0219489
   Gonai M, 2017, BENEF MICROBES, V8, P705, DOI 10.3920/BM2016.0230
   Graessler J, 2013, PHARMACOGENOMICS J, V13, P514, DOI 10.1038/tpj.2012.43
   Gu YY, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-01682-2
   Guo Y, 2018, EUR J ENDOCRINOL, V178, P43, DOI [10.1530/EJE-17-0403, 10.1530/eje-17-0403]
   He Lin, 2021, COATINGS, V13, P6209, DOI [10.3390/cancers10020049, DOI 10.3390/COATINGS10070687, 10.3390/cancers13246209]
   Horvath A, 2020, EUR J NUTR, V59, P2969, DOI 10.1007/s00394-019-02135-w
   Horvath Angela, 2019, EUR J NUTR, V59, P2969, DOI [10.1007/s00394-019-02135-w, DOI 10.1007/S00394-019-02135-W, DOI 10.1007/s00394-019-02065-7]
   Huang F, 2018, INT J FOOD SCI NUTR, V69, P729, DOI 10.1080/09637486.2017.1408059
   Huang XF, 2014, J DIABETES RES, V2014, DOI 10.1155/2014/196312
   Huda MN, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.632335
   Ismael S, 2021, NUTRIENTS, V13, DOI 10.3390/nu13041228
   Kanazawa A, 2021, NUTRIENTS, V13, DOI 10.3390/nu13020558
   Karusheva Y, 2019, AM J CLIN NUTR, V110, P1098, DOI 10.1093/ajcn/nqz191
   Kim MS, 2013, ENV MICROBIOL REP, V5, P765, DOI 10.1111/1758-2229.12079
   Knudsen KEB, 2018, NUTRIENTS, V10, DOI 10.3390/nu10101499
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Lau E, 2021, DIABETOL METAB SYNDR, V13, DOI 10.1186/s13098-021-00672-1
   Lee CJ, 2019, OBES SURG, V29, P3239, DOI 10.1007/s11695-019-03976-4
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Lee SE, 2019, DIABETES METAB J, V43, P422, DOI 10.4093/dmj.2018.0090
   Liu CG, 2020, EXP THER MED, V20, DOI 10.3892/etm.2020.9167
   Liu HJ, 2018, SURG OBES RELAT DIS, V14, P584, DOI 10.1016/j.soard.2018.01.012
   Luijten JCHBM, 2019, OBES SURG, V29, P2338, DOI 10.1007/s11695-019-03863-y
   Medina-Vera I, 2019, DIABETES METAB, V45, P122, DOI 10.1016/j.diabet.2018.09.004
   Mobini R, 2017, DIABETES OBES METAB, V19, P579, DOI 10.1111/dom.12861
   Morales-Marroquin E, 2020, OBES REV, V21, DOI 10.1111/obr.13025
   Moreira GV, 2018, J NUTR BIOCHEM, V62, P143, DOI 10.1016/j.jnutbio.2018.07.009
   Mueller NT, 2021, DIABETES CARE, V44, P1462, DOI 10.2337/dc20-2257
   Murphy R, 2017, OBES SURG, V27, P917, DOI 10.1007/s11695-016-2399-2
   Nakajima H, 2020, LIFE-BASEL, V10, DOI 10.3390/life10090195
   Napolitano A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100778
   Ojo O, 2020, NUTRIENTS, V12, DOI 10.3390/nu12113239
   Palacios T, 2020, NUTRIENTS, V12, DOI 10.3390/nu12072041
   Pascale A, 2019, CURR OPIN PHARMACOL, V49, P1, DOI 10.1016/j.coph.2019.03.011
   Pasini E, 2019, MINERVA MED, V110, P3, DOI 10.23736/S0026-4806.18.05589-1
   Patel Kanika, CURR MED CHEM, V15, P369, DOI [10.2174/1573407214666180511153438, DOI 10.2174/0929867043365251]
   Pedersen C, 2016, BRIT J NUTR, V116, P1869, DOI 10.1017/S0007114516004086
   Plovier H, 2017, NAT MED, V23, P107, DOI 10.1038/nm.4236
   Remely M, 2016, ENDOCR METAB IMMUNE, V16, P99, DOI 10.2174/1871530316666160831093813
   Remely M, 2014, GENE, V537, P85, DOI 10.1016/j.gene.2013.11.081
   Ren MX, 2020, NUTRIENTS, V12, DOI 10.3390/nu12103036
   Salamon D, 2018, POL ARCH INTERN MED, V128, P336, DOI 10.20452/pamw.4246
   Sanna S, 2019, NAT GENET, V51, P600, DOI 10.1038/s41588-019-0350-x
   Sasaki M, 2013, BMC GASTROENTEROL, V13, DOI 10.1186/1471-230X-13-81
   Sato J, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-12535-9
   Shimozato A, 2017, UNITED EUR GASTROENT, V5, P898, DOI 10.1177/2050640617692268
   Shin NR, 2020, AM J PHYSIOL-ENDOC M, V318, pE52, DOI 10.1152/ajpendo.00221.2019
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Shortt C, 2018, EUR J NUTR, V57, P25, DOI 10.1007/s00394-017-1546-4
   Singh RK, 2017, J TRANSL MED, V15, DOI 10.1186/s12967-017-1175-y
   Smits MM, 2021, DIABETES METAB, V47, DOI 10.1016/j.diabet.2021.101223
   Stefanaki C, 2017, METABOLISM, V73, P52, DOI 10.1016/j.metabol.2017.04.014
   Sterne JAC, 2019, BMJ-BRIT MED J, V366, DOI 10.1136/bmj.l4898
   Su BL, 2015, J DIABETES, V7, P729, DOI 10.1111/1753-0407.12232
   Takewaki F, 2021, NUTRIENTS, V13, DOI 10.3390/nu13062107
   Tang Li, 2020, REV AQUACULT, V24, P4915, DOI [10.1111/j.1442-9993.2011.02319.x, DOI 10.1111/RAQ.12464, 10.1111/jcmm.14917]
   Thakuria, 2015, INT J CURR PHARM RES, V7, P33
   Tong XL, 2018, MBIO, V9, DOI 10.1128/mBio.02392-17
   Umirah F, 2021, DIABETES RES CLIN PR, V173, DOI 10.1016/j.diabres.2021.108689
   van Bommel EJM, 2020, DIABETES METAB, V46, P164, DOI 10.1016/j.diabet.2019.11.005
   Wallenius V, 2020, GUT, V69, P1423, DOI 10.1136/gutjnl-2019-319372
   Wang FG, 2019, EXP THER MED, V17, P2268, DOI 10.3892/etm.2019.7200
   Wang YJ, 2021, GUT PATHOG, V13, DOI 10.1186/s13099-020-00396-z
   Wang Yijia, 2021, GUT PATHOG, V13, DOI [10.1186/s13099-020-00396-z, DOI 10.1186/S13099-020-00396-Z]
   Wang Zhang, 2018, Endocrinol Diabetes Metab, V1, pe00009, DOI 10.1002/edm2.9
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Wu XK, 2010, CURR MICROBIOL, V61, P69, DOI 10.1007/s00284-010-9582-9
   Xiao Wen, ANIM BEHAV, V61, P507, DOI [DOI 10.1016/J.ANBEHAV.2014.11.002, 10.1371/journal.pmed.1002841]
   Xu Baofang, 2020, ENVIRON SCI POLLUT R, V78, P129, DOI [10.1007/s00018-020-03594-9, DOI 10.1007/S11356-016-8017-Y]
   Xu J, 2015, ISME J, V9, P552, DOI 10.1038/ismej.2014.177
   Young VB, 2017, BMJ-BRIT MED J, V356, DOI 10.1136/bmj.j831
   Zhang SL, 2021, DIABETES RES CLIN PR, V172, DOI 10.1016/j.diabres.2020.108645
   Zhang XY, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0071108
   Zhang YF, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-18414-8
   Zhao Q, 2019, J PHARM PHARMACOL, V71, P806, DOI 10.1111/jphp.13048
   Zheng Junlin, EUR J PHARMACOL, V206, P241, DOI [10.1016/j.chemosphere.2018.09.180, DOI 10.1016/J.EJPHAR.2018.08.021, 10.1016/j.agwat.2018.05.008]
NR 97
TC 0
Z9 0
U1 4
U2 6
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0168-8227
EI 1872-8227
J9 DIABETES RES CLIN PR
JI Diabetes Res. Clin. Pract.
PD JUL
PY 2022
VL 189
AR 109944
DI 10.1016/j.diabres.2022.109944
PG 19
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 5W2ZU
UT WOS:000877789600002
PM 35697155
DA 2023-06-08
ER

PT J
AU Boursi, B
   Werner, TJ
   Gholami, S
   Houshmand, S
   Mamtani, R
   Lewis, JD
   Wu, GD
   Alavi, A
   Yang, YX
AF Boursi, Ben
   Werner, Thomas J.
   Gholami, Saeid
   Houshmand, Sina
   Mamtani, Ronac
   Lewis, James D.
   Wu, Gary D.
   Alavi, Abass
   Yang, Yu-Xiao
TI Functional imaging of the interaction between gut microbiota and the
   human host: A proof-of-concept clinical study evaluating novel use for
   18F-FDG PET-CT
SO PLOS ONE
LA English
DT Article
ID INTESTINAL F-18-FDG UPTAKE; METFORMIN; ANTIBIOTICS; METAGENOME; COLON
AB Recent data comparing germ-free to conventionally-raised mice demonstrated that energy homeostasis of colonocytes is dependent on gut microbiota through regulation of short chain fatty acids (SCFA) production and glucose utilization. We sought to evaluate 18F-FDG PET-CT as a novel technique for functional imaging of alterations in glucose metabolism as a result of the interaction between the gut microbiota and the human host. We conducted a prospective study in healthy humans that underwent 18F-FDG PET-CT and sampling of the gut microbiota before and after orally administered broad-spectrum antibiotics. The primary outcomes were total and regional physiologic colonic 18F-FDG uptake (measured as the mean and max standardized uptake values [SUVmean and SUVmax]). The study demonstrated significant increases in physiologic colonic 18F-FDG uptake in all study participants following antibiotic treatment and a 4-5log reduction of gut bacterial load. The mean increase in SUVmax was 0.63 +/- 0.37 SD (p = 0.004) and the median increase was 0.42 with an IQR of 0.40-0.81. The mean increase in SUVmean was 0.31 +/- 0.24 SD (p = 0.01) and the median increase was 0.41 with an IQR of 0.06-0.55. A likely explanation for this phenomenon is a shift in colonocyte metabolism to glycolysis due to a shortage of SCFA.
C1 [Boursi, Ben; Lewis, James D.; Wu, Gary D.; Yang, Yu-Xiao] Univ Penn, Perelman Sch Med, Dept Med, Div Gastroenterol, Philadelphia, PA 19104 USA.
   [Boursi, Ben; Mamtani, Ronac; Lewis, James D.; Yang, Yu-Xiao] Univ Penn, Perelman Sch Med, Ctr Clin Epidemiol & Biostat, Philadelphia, PA 19104 USA.
   [Boursi, Ben; Mamtani, Ronac] Univ Penn, Abramson Canc Ctr, Philadelphia, PA 19104 USA.
   [Boursi, Ben] Tel Aviv Univ, Tel Aviv, Israel.
   [Boursi, Ben] Sheba Med Ctr, Dept Oncol, Ramat Gan, Israel.
   [Werner, Thomas J.; Gholami, Saeid; Houshmand, Sina; Alavi, Abass] Univ Penn, Perelman Sch Med, Dept Nucl Med, Philadelphia, PA 19104 USA.
C3 University of Pennsylvania; Pennsylvania Medicine; University of
   Pennsylvania; Pennsylvania Medicine; University of Pennsylvania;
   Pennsylvania Medicine; Tel Aviv University; Chaim Sheba Medical Center;
   University of Pennsylvania; Pennsylvania Medicine
RP Boursi, B (通讯作者)，Univ Penn, Perelman Sch Med, Dept Med, Div Gastroenterol, Philadelphia, PA 19104 USA.; Boursi, B (通讯作者)，Univ Penn, Perelman Sch Med, Ctr Clin Epidemiol & Biostat, Philadelphia, PA 19104 USA.; Boursi, B (通讯作者)，Univ Penn, Abramson Canc Ctr, Philadelphia, PA 19104 USA.; Boursi, B (通讯作者)，Tel Aviv Univ, Tel Aviv, Israel.; Boursi, B (通讯作者)，Sheba Med Ctr, Dept Oncol, Ramat Gan, Israel.
EM ben.boursi@sheba.health.gov.il
RI Houshmand, Sina/HGU-1215-2022; yang, yx/GZM-0464-2022
OI Yang, Yu-Xiao/0000-0002-3690-9174
FU NCI NIH HHS [K23 CA187185] Funding Source: Medline
CR Abreu MT, 2014, GASTROENTEROLOGY, V146, P1534, DOI 10.1053/j.gastro.2014.01.001
   Bahler L, 2016, DIABETES RES CLIN PR, V114, P55, DOI 10.1016/j.diabres.2016.02.009
   BENDER JF, 1979, ANTIMICROB AGENTS CH, V15, P455, DOI 10.1128/AAC.15.3.455
   Brader P, 2008, CLIN CANCER RES, V14, P2295, DOI 10.1158/1078-0432.CCR-07-4254
   Capitanio S, 2015, WORLD J RADIOL, V7, P57, DOI 10.4329/wjr.v7.i3.57
   Cho I, 2012, NATURE, V488, P621, DOI 10.1038/nature11400
   Cox LM, 2014, CELL, V158, P705, DOI 10.1016/j.cell.2014.05.052
   Dejea CM, 2014, P NATL ACAD SCI USA, V111, P18321, DOI 10.1073/pnas.1406199111
   Donohoe DR, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0046589
   Franquet E, 2014, NUCL MED COMMUN, V35, P1026, DOI 10.1097/MNM.0000000000000170
   Ghosh SS, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0108577
   Gontier E, 2008, EUR J NUCL MED MOL I, V35, P95, DOI 10.1007/s00259-007-0563-6
   Hevia A, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0147809
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Ling ZX, 2014, APPL ENVIRON MICROB, V80, P2546, DOI 10.1128/AEM.00003-14
   Maloy KJ, 2011, NATURE, V474, P298, DOI 10.1038/nature10208
   Marchesi JR, 2016, GUT, V65, P330, DOI 10.1136/gutjnl-2015-309990
   Massollo M, 2013, J NUCL MED, V54, P259, DOI 10.2967/jnumed.112.106666
   Mihaylova MM, 2011, NAT CELL BIOL, V13, P1016, DOI 10.1038/ncb2329
   Ni J, 2017, SCI TRANSL MED, V9, P416
   Nylund L, 2015, ALLERGY, V70, P241, DOI 10.1111/all.12549
   Oh JR, 2010, AM J ROENTGENOL, V195, P1404, DOI 10.2214/AJR.10.4663
   Ozulker T, 2010, EUR J NUCL MED MOL I, V37, P1011, DOI 10.1007/s00259-009-1330-7
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   REDDY BS, 1975, CANCER RES, V35, P287
   ROEDIGER WEW, 1982, GASTROENTEROLOGY, V83, P424
   ROEDIGER WEW, 1980, GUT, V21, P793, DOI 10.1136/gut.21.9.793
   Sobhani I, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0016393
   Steenkamp DW, 2014, ENDOCR PRACT, V20, P1079, DOI 10.4158/EP14127.RA
   Tatlidil R, 2002, RADIOLOGY, V224, P783, DOI 10.1148/radiol.2243011214
   Weir TL, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0070803
   Zhang X, 2015, NAT MED, V21, P895, DOI 10.1038/nm.3914
NR 32
TC 12
Z9 12
U1 2
U2 7
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD FEB 15
PY 2018
VL 13
IS 2
AR e0192747
DI 10.1371/journal.pone.0192747
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA FW4LB
UT WOS:000425283900051
PM 29447210
OA Green Published, gold, Green Submitted
DA 2023-06-08
ER

PT J
AU Craciun, CI
   Neag, MA
   Catinean, A
   Mitre, AO
   Rusu, A
   Bala, C
   Roman, G
   Buzoianu, AD
   Muntean, DM
   Craciun, AE
AF Craciun, Cristian-Ioan
   Neag, Maria-Adriana
   Catinean, Adrian
   Mitre, Andrei-Otto
   Rusu, Adriana
   Bala, Cornelia
   Roman, Gabriela
   Buzoianu, Anca-Dana
   Muntean, Dana-Maria
   Craciun, Anca-Elena
TI The Relationships between Gut Microbiota and Diabetes Mellitus, and
   Treatments for Diabetes Mellitus
SO BIOMEDICINES
LA English
DT Article
DE microbiota; diabetes mellitus; inflammation; nutraceuticals;
   Bacteroides; Firmicutes
ID CHAIN FATTY-ACIDS; OXIDATIVE STRESS; DOUBLE-BLIND; GLYCEMIC CONTROL;
   GLUCOSE; DIET; INFLAMMATION; METFORMIN; PROBIOTICS; ACARBOSE
AB Diabetes mellitus is considered to be a global epidemic. The combination of genetic susceptibility and an unhealthy lifestyle is considered to be the main trigger of this metabolic disorder. Recently, there has been increased interest in the roles of gut microbiota as a new potential contributor to this epidemic. Research, in recent years, has contributed to an in-depth characterization of the human microbiome and its associations with various diseases, including metabolic diseases and diabetes mellitus. It is known that diet can change the composition of gut microbiota, but it is unclear how this, in turn, may influence metabolism. The main objective of this review is to evaluate the pathogenetic association between microbiota and diabetes and to explore any new therapeutic agents, including nutraceuticals that may modulate the microbiota. We also look at several mechanisms involved in this process. There is a clear, bidirectional relationship between microbiota and diabetes. Current treatments for diabetes influence microbiota in various ways, some beneficial, but others with still unclear effects. Microbiota-aimed treatments have seen no real-world significant effects on the progression of diabetes and its complications, with more studies needed in order to find a really beneficial agent.
C1 [Craciun, Cristian-Ioan; Neag, Maria-Adriana; Buzoianu, Anca-Dana] Iuliu Hatieganu Univ Med & Pharm, Dept Pharmacol Toxicol & Clin Pharmacol, Cluj Napoca 400337, Romania.
   [Catinean, Adrian] Iuliu Hatieganu Univ Med & Pharm, Dept Internal Med, Cluj Napoca 400006, Romania.
   [Mitre, Andrei-Otto] Iuliu Hatieganu Univ Med & Pharm, Fac Med, Cluj Napoca 400012, Romania.
   [Rusu, Adriana; Bala, Cornelia; Roman, Gabriela; Craciun, Anca-Elena] Iuliu Hatieganu Univ Med & Pharm, Dept Diabet, Nutr, Metab Dis, Cluj Napoca 400006, Romania.
   [Muntean, Dana-Maria] Iuliu Hatieganu Univ Med & Pharm, Dept Pharmaceut Technol & Biopharmaceut, Cluj Napoca 400012, Romania.
C3 Iuliu Hatieganu University of Medicine & Pharmacy; Iuliu Hatieganu
   University of Medicine & Pharmacy; Iuliu Hatieganu University of
   Medicine & Pharmacy; Iuliu Hatieganu University of Medicine & Pharmacy;
   Iuliu Hatieganu University of Medicine & Pharmacy
RP Neag, MA (通讯作者)，Iuliu Hatieganu Univ Med & Pharm, Dept Pharmacol Toxicol & Clin Pharmacol, Cluj Napoca 400337, Romania.
EM cristian.craciun@umfcluj.ro; maria.neag@umfcluj.ro; catinean@gmail.com;
   andrei.otto.mitre@elearn.umfcluj.ro; adriana.rusu@umfcluj.ro;
   cbala@umfcluj.ro; groman@umfcluj.ro; abuzoianu@umfcluj.ro;
   dana.muntean@umfcluj.ro; anca.craciun@umfcluj.ro
RI Rusu, Adriana/I-5260-2019; Craciun (Ciocan), Anca Elena/A-4795-2019;
   Buzoianu, Anca Dana/M-1050-2017; Muntean, Dana/C-4220-2011
OI Rusu, Adriana/0000-0003-0977-8874; Craciun (Ciocan), Anca
   Elena/0000-0001-5373-4743; Buzoianu, Anca Dana/0000-0002-3511-2788;
   Muntean, Dana/0000-0002-3914-0110; catinean, adrian/0000-0002-6327-6608;
   Bala, Cornelia/0000-0001-6216-9088
CR Adeshirlarijaney A, 2020, GUT MICROBES, V11, P253, DOI 10.1080/19490976.2020.1717719
   Agrawal NK, 2014, WORLD J DIABETES, V5, P697, DOI 10.4239/wjd.v5.i5.697
   Agus A, 2021, GUT, V70, P1174, DOI 10.1136/gutjnl-2020-323071
   Ahmad A, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0226372
   Akash MSH, 2018, J CELL BIOCHEM, V119, P105, DOI 10.1002/jcb.26174
   Al-Salami Hani, 2008, Arch Drug Inf, V1, P35, DOI 10.1111/j.1753-5174.2008.00006.x
   Gonzalez-Regueiro JA, 2017, ANN HEPATOL, V16, pS15, DOI [10.5604/01.3001.0010.5672, 10.5604/01.3001.0010.5494]
   Amer B, 2015, LIPIDS, V50, P681, DOI 10.1007/s11745-015-4029-5
   American Diabetes Association, 2021, DIABETES CARE, V44, pS226
   Andersson U, 2010, BENEF MICROBES, V1, P189, DOI 10.3920/BM2009.0036
   Asemi Z, 2016, CLIN NUTR, V35, P819, DOI 10.1016/j.clnu.2015.07.009
   Asemi Z, 2013, ANN NUTR METAB, V63, P1, DOI 10.1159/000349922
   Ashcroft FM, 1996, HORM METAB RES, V28, P456, DOI 10.1055/s-2007-979837
   Bai J, 2016, J ETHNOPHARMACOL, V194, P717, DOI 10.1016/j.jep.2016.10.043
   BAILEY CJ, 1992, BRIT J PHARMACOL, V105, P1009, DOI 10.1111/j.1476-5381.1992.tb09093.x
   Bejar W, 2013, ANAEROBE, V24, P4, DOI 10.1016/j.anaerobe.2013.08.006
   Blandino G, 2016, DIABETES METAB, V42, P303, DOI 10.1016/j.diabet.2016.04.004
   Brown J, 2018, DIABETES, V67, DOI 10.2337/db18-1970-P
   Brunkwall L, 2017, DIABETOLOGIA, V60, P943, DOI 10.1007/s00125-017-4278-3
   Cabrera SM, 2016, TRANSL RES, V167, P214, DOI 10.1016/j.trsl.2015.04.011
   Caio G, 2020, NUTRIENTS, V12, DOI 10.3390/nu12061832
   Calabrese CM, 2021, FRONT NUTR, V7, DOI 10.3389/fnut.2020.612773
   Catinean A, 2019, MICROORGANISMS, V7, DOI 10.3390/microorganisms7090279
   Caturano A, 2021, PROCESSES, V9, DOI 10.3390/pr9010135
   Cefalo CMA, 2019, CARDIOVASC DIABETOL, V18, DOI 10.1186/s12933-019-0828-y
   Chen MJ, 2021, STEROIDS, V165, DOI 10.1016/j.steroids.2020.108757
   Chen ZL, 2021, DIABETES CARE, V44, P663, DOI 10.2337/dc20-1636
   Chiang JYL, 2017, DIGEST DIS, V35, P241, DOI 10.1159/000450981
   Chiang JYL, 2009, J LIPID RES, V50, P1955, DOI 10.1194/jlr.R900010-JLR200
   Cortes-Macias E, 2021, J NUTR, V151, P330, DOI 10.1093/jn/nxaa310
   Couto MR, 2020, PHARMACOL RES, V159, DOI 10.1016/j.phrs.2020.104947
   Cox AJ, 2017, DIABETES METAB, V43, P163, DOI 10.1016/j.diabet.2016.09.004
   Danic M, 2021, EUR J PHARM SCI, V158, DOI 10.1016/j.ejps.2020.105668
   De Filippo C, 2010, P NATL ACAD SCI USA, V107, P14691, DOI 10.1073/pnas.1005963107
   Dedrick S, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.00078
   Delzenne NM, 2015, DIABETOLOGIA, V58, P2206, DOI 10.1007/s00125-015-3712-7
   Du FY, 2018, J PHARMACOL EXP THER, V365, P676, DOI 10.1124/jpet.118.248575
   Ebrahimi ZS, 2017, J DIABETES METAB DIS, V16, DOI 10.1186/s40200-017-0304-8
   Egshatyan L, 2016, ENDOCR CONNECT, V5, P1, DOI 10.1530/EC-15-0094
   Ejtahed HS, 2012, NUTRITION, V28, P539, DOI 10.1016/j.nut.2011.08.013
   Eslami M, 2021, DIABETIC MED, V38, DOI 10.1111/dme.14415
   Evans CC, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0092193
   Feng WW, 2018, FRONT PHARMACOL, V9, DOI 10.3389/fphar.2018.01354
   Firouzi S, 2017, EUR J NUTR, V56, P1535, DOI 10.1007/s00394-016-1199-8
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Garibotto G, 2017, J NEPHROL, V30, P719, DOI 10.1007/s40620-017-0432-8
   Garrett WS, 2015, SCIENCE, V348, P80, DOI 10.1126/science.aaa4972
   Ghosh TS, 2020, GUT, V69, P1218, DOI 10.1136/gutjnl-2019-319654
   Gu YY, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-01682-2
   Guo SH, 2015, J IMMUNOL, V195, P4999, DOI 10.4049/jimmunol.1402598
   Halim M, 2019, DIABETES METAB SYND, V13, P1165, DOI 10.1016/j.dsx.2019.01.040
   Haro C, 2016, J CLIN ENDOCR METAB, V101, P232, DOI 10.1210/jc.2015-3351
   Hauner H, 2002, DIABETES-METAB RES, V18, pS10, DOI 10.1002/dmrr.249
   Hernandez MAG, 2019, NUTRIENTS, V11, DOI 10.3390/nu11081943
   Ho J, 2019, J CLIN ENDOCR METAB, V104, P4427, DOI 10.1210/jc.2019-00481
   Holodniy M, 2011, PLOS ONE, V6, DOI [10.1371/journal.pone.0014764, 10.1371/journal.pone.0025792]
   Hsieh MC, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-35014-1
   Hu N, 2022, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.794103
   International Diabetes Federation, 2019, IDF DIABETES ATLAS
   Jamshidi P, 2019, GUT PATHOG, V11, DOI 10.1186/s13099-019-0332-7
   Kalra S, 2014, DIABETES THER, V5, P355, DOI 10.1007/s13300-014-0089-4
   Karakan T, 2019, TURK J GASTROENTEROL, V30, P1008, DOI 10.5152/tjg.2019.101219
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kihl P, 2018, DIABETES-METAB RES, V34, DOI 10.1002/dmrr.3010
   Kim JW, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20194871
   Kimura I, 2014, FRONT ENDOCRINOL, V5, DOI 10.3389/fendo.2014.00085
   Kobyliak N, 2018, DIABETES METAB SYND, V12, P617, DOI 10.1016/j.dsx.2018.04.015
   Kvitvang Hans Fredrik Nyvold, 2014, Methods Mol Biol, V1198, P137, DOI 10.1007/978-1-4939-1258-2_10
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Laugerette F, 2014, MOL NUTR FOOD RES, V58, P1513, DOI 10.1002/mnfr.201400044
   Lee CB, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22073566
   Lee DM, 2018, CARDIOVASC DIABETOL, V17, DOI 10.1186/s12933-018-0708-x
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Li KK, 2017, J FUNCT FOODS, V38, P561, DOI 10.1016/j.jff.2017.09.049
   Li TY, 2019, MOL IMMUNOL, V112, P322, DOI 10.1016/j.molimm.2019.06.008
   Libertucci J, 2019, NAT MICROBIOL, V4, P35, DOI 10.1038/s41564-018-0278-4
   Lin R, 2017, AMINO ACIDS, V49, P2083, DOI 10.1007/s00726-017-2493-3
   Madsen MSA, 2021, BIOMED PHARMACOTHER, V133, DOI 10.1016/j.biopha.2020.110966
   Madsen MSA, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-52103-x
   Mannucci E, 2001, DIABETES CARE, V24, P489, DOI 10.2337/diacare.24.3.489
   Matsumoto M, 2008, BIOSCI BIOTECH BIOCH, V72, P572, DOI 10.1271/bbb.70474
   Mazloom Z, 2013, IRAN J MED SCI, V38, P38
   Mobini R, 2017, DIABETES OBES METAB, V19, P579, DOI 10.1111/dom.12861
   Monda V, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/3831972
   Montandon SA, 2017, GENES-BASEL, V8, DOI 10.3390/genes8100250
   Moroti C, 2012, LIPIDS HEALTH DIS, V11, DOI 10.1186/1476-511X-11-29
   Muller M, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-48775-0
   Munoz-Garach A, 2016, ENDOCRINOL NUTR, V63, P560, DOI 10.1016/j.endonu.2016.07.008
   Murri M, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-46
   Nakajima H, 2020, LIFE-BASEL, V10, DOI 10.3390/life10090195
   Navab-Moghadam F, 2017, MICROB PATHOGENESIS, V110, P630, DOI 10.1016/j.micpath.2017.07.034
   Neag MA, 2021, WORLD J GASTROENTERO, V27, P7446, DOI 10.3748/wjg.v27.i43.7446
   Olivares M, 2018, DIABETOLOGIA, V61, P1838, DOI 10.1007/s00125-018-4647-6
   Venegas DP, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.00277
   Raafat K, 2016, BIOMED PHARMACOTHER, V84, P1008, DOI 10.1016/j.biopha.2016.09.095
   Raygan F, 2018, DIABETOL METAB SYNDR, V10, DOI 10.1186/s13098-018-0353-2
   Rinaldi L, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10020270
   Rinninella E, 2019, MICROORGANISMS, V7, DOI 10.3390/microorganisms7010014
   Rodriguez J, 2018, CURR OPIN CLIN NUTR, V21, P294, DOI 10.1097/MCO.0000000000000468
   Roshanravan N, 2020, CYTOKINE, V131, DOI 10.1016/j.cyto.2020.155101
   Russell WR, 2011, AM J CLIN NUTR, V93, P1062, DOI 10.3945/ajcn.110.002188
   Sato J, 2014, DIABETES CARE, V37, P2343, DOI 10.2337/dc13-2817
   Scheithauer TPM, 2020, FRONT IMMUNOL, V11, DOI 10.3389/fimmu.2020.571731
   Sedighi M, 2017, MICROB PATHOGENESIS, V111, P362, DOI 10.1016/j.micpath.2017.08.038
   Sevastre-Berghian AC, 2020, FRONT PHARMACOL, V11, DOI 10.3389/fphar.2020.581470
   Shao Y, 2019, NATURE, V574, P117, DOI 10.1038/s41586-019-1560-1
   Singh RK, 2017, J TRANSL MED, V15, DOI 10.1186/s12967-017-1175-y
   Singh S, 2017, BENEF MICROBES, V8, P243, DOI 10.3920/BM2016.0090
   Smits MM, 2021, DIABETES METAB, V47, DOI 10.1016/j.diabet.2021.101223
   Su BL, 2015, J DIABETES, V7, P729, DOI 10.1111/1753-0407.12232
   Suez J, 2014, NATURE, V514, P181, DOI 10.1038/nature13793
   Tedelind S, 2007, WORLD J GASTROENTERO, V13, P2826, DOI 10.3748/wjg.v13.i20.2826
   Le TKC, 2015, BIOMED RES-TOKYO, V36, P63, DOI 10.2220/biomedres.36.63
   Thornberry NA, 2009, BEST PRACT RES CL EN, V23, P479, DOI 10.1016/j.beem.2009.03.004
   Thursby E, 2017, BIOCHEM J, V474, P1823, DOI 10.1042/BCJ20160510
   Tomas J, 2016, P NATL ACAD SCI USA, V113, pE5934, DOI 10.1073/pnas.1612559113
   Tsai CY, 2022, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.814770
   Tsalamandris S, 2019, EUR CARDIOL REV, V14, P50, DOI 10.15420/ecr.2018.33.1
   Tsikas D, 2017, J CHROMATOGR B, V1043, P187, DOI 10.1016/j.jchromb.2016.08.015
   Tsuji H, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.01417
   van Bommel EJM, 2020, DIABETES METAB, V46, P164, DOI 10.1016/j.diabet.2019.11.005
   van den Elsen LWJ, 2019, FRONT PEDIATR, V7, DOI 10.3389/fped.2019.00047
   Wang G, 2017, FOOD FUNCT, V8, P3155, DOI 10.1039/c7fo00593h
   Wang L, 2016, SCI REP-UK, V6, DOI [10.1038/srep38380, 10.1038/srep33251, 10.1038/srep20004]
   Weaver GA, 1997, J NUTR, V127, P717, DOI 10.1093/jn/127.5.717
   Whang A, 2019, EBIOMEDICINE, V39, P591, DOI 10.1016/j.ebiom.2018.11.046
   Wickens KL, 2017, BRIT J NUTR, V117, P804, DOI [10.1017/S0007114517000289, 10.1017/s0007114517000289]
   Wu TZ, 2014, DIABETES RES CLIN PR, V106, pE3, DOI 10.1016/j.diabres.2014.08.004
   Xu YQ, 2020, TRENDS FOOD SCI TECH, V100, P118, DOI 10.1016/j.tifs.2020.02.026
   Yadav H, 2008, J DAIRY RES, V75, P189, DOI 10.1017/S0022029908003129
   Yadav R, 2018, MICROB PATHOGENESIS, V125, P454, DOI 10.1016/j.micpath.2018.10.015
   Yan XF, 2016, J DIABETES RES, V2016, DOI 10.1155/2016/2093171
   Yang M, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.00635
   Yun SI, 2009, J APPL MICROBIOL, V107, P1681, DOI 10.1111/j.1365-2672.2009.04350.x
   Zeng Z, 2019, MOL NUTR FOOD RES, V63, DOI 10.1002/mnfr.201900457
   Zhang CH, 2010, ISME J, V4, P232, DOI 10.1038/ismej.2009.112
   Zhang Q, 2018, PEERJ, V6, DOI 10.7717/peerj.4446
   Zhang Q, 2018, EXP BIOL MED, V243, P34, DOI 10.1177/1535370217743765
   Zhang Q, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0184735
   Zhang XY, 2017, DIABETES THER, V8, P293, DOI 10.1007/s13300-017-0226-y
   Zhang X, 2015, SCI REP-UK, V5, DOI 10.1038/srep14405
   Zhao D, 2020, FOOD FUNCT, V11, P6528, DOI [10.1039/d0fo00180e, 10.1039/D0FO00180E]
   Zheng DP, 2020, CELL RES, V30, P492, DOI 10.1038/s41422-020-0332-7
   Zhou H, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.00125
NR 144
TC 8
Z9 8
U1 11
U2 27
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9059
J9 BIOMEDICINES
JI Biomedicines
PD FEB
PY 2022
VL 10
IS 2
AR 308
DI 10.3390/biomedicines10020308
PG 19
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA ZL5XA
UT WOS:000763748700001
PM 35203519
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Lin, XJ
   Luo, ZT
   Pang, SQ
   Wang, CC
   Ge, L
   Dai, YL
   Zhou, J
   Chen, F
   Hong, XP
   Zhang, JH
AF Lin, Xinjun
   Luo, Zongting
   Pang, Shuqin
   Wang, Carol Chunfeng
   Ge, Li
   Dai, Yanling
   Zhou, Jian
   Chen, Fang
   Hong, Xuepei
   Zhang, Jiahui
TI The effects of yam gruel on lowering fasted blood glucose in T2DM rats
SO OPEN LIFE SCIENCES
LA English
DT Article
DE yam gruel; gut microbiota; short-chain fatty acids; 16S rRNA gene
   sequencing; supplement therapy
ID CHAIN FATTY-ACIDS; GUT MICROBIOTA; SECRETION
AB There is increasing evidence of the linkage between type 2 diabetes mellitus (T2DM) and gut microbiota. Based on our previous studies, we investigated the hypoglycemic mechanisms of yam gruel to provide a scientific basis for its popularization and application. Wistar rats were randomly divided into control and T2DM model groups. Rats in the model group were stimulated by a high-sugar/high-fat diet combined with an intraperitoneal injection of streptozotocin to induce T2DM. The T2DM rats were further subdivided randomly into three groups: (1) DM, (2) DM + yam gruel, and (3) DM + metformin. After 4 weeks of intervention, the changes in gut microbiota, short-chain fatty acids (SCFAs) (acetic acid, propionic acid, and butyric acid), the expression of G protein-coupled receptor 43 (GPR43), glucagon-like peptide-1 (GLP-1), peptide YY (PYY), and fasted blood glucose (FBG) levels were observed. Yam gruel intervention elevated the abundance of probiotic bacteria and increased the expression of SCFAs, GPR43 receptor, GLP-1, and PYY. It also reduced FBG levels. We conclude that yam gruel can lower FBG by promoting the growth of probiotic bacteria, increasing the content of SCFAs, and enhancing the expression of GPR43 receptor to increase the content of GLP-1 and PYY in serum.
C1 [Luo, Zongting; Pang, Shuqin; Ge, Li; Dai, Yanling; Zhou, Jian; Chen, Fang; Hong, Xuepei; Zhang, Jiahui] Fujian Univ Tradit Chinese Med, Sch Nursing, Fuzhou 350122, Fujian, Peoples R China.
   [Lin, Xinjun] Fujian Univ Tradit Chinese Med, Inst Integrated Chinese & Western Med, Fuzhou 350122, Fujian, Peoples R China.
   [Wang, Carol Chunfeng] Edith Cowan Univ, Sch Nursing & Midwifery, Perth, WA 6027, Australia.
C3 Fujian University of Traditional Chinese Medicine; Fujian University of
   Traditional Chinese Medicine; Edith Cowan University
RP Pang, SQ (通讯作者)，Fujian Univ Tradit Chinese Med, Sch Nursing, Fuzhou 350122, Fujian, Peoples R China.
EM 1205627027@qq.com
OI Wang, Dr Carol Chunfeng/0000-0002-6672-7187
FU Science and Technology Platform Construction Project of Fujian Science
   and Technology Department [2015Y2001-51]; National Natural Science
   Foundation of China [81503438]
FX This work was supported by the Science and Technology Platform
   Construction Project of Fujian Science and Technology Department (Grant
   No. 2015Y2001-51) and National Natural Science Foundation of China
   (Grant No. 81503438).
CR Amoah Vida Maame Kissiwaa, 2018, BMC Res Notes, V11, P66, DOI 10.1186/s13104-018-3176-1
   [Anonymous], 2018, CHIN J PRACT INTERNA, V38, P292
   Bolognini D, 2016, MOL PHARMACOL, V89, P388, DOI 10.1124/mol.115.102301
   Brooks L, 2017, MOL METAB, V6, P48, DOI 10.1016/j.molmet.2016.10.011
   Brunkwall L, 2017, DIABETOLOGIA, V60, P943, DOI 10.1007/s00125-017-4278-3
   Chapman D, 2019, DIABETES THER, V10, P575, DOI 10.1007/s13300-018-0548-4
   Choi YY, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0188904
   Christiansen CB, 2018, AM J PHYSIOL-GASTR L, V315, pG53, DOI 10.1152/ajpgi.00346.2017
   Cui Tao, 2013, Sichuan Da Xue Xue Bao Yi Xue Ban, V44, P774
   Faselis C, 2020, CURR VASC PHARMACOL, V18, P117, DOI 10.2174/1570161117666190502103733
   Harding JL, 2019, DIABETOLOGIA, V62, P3, DOI 10.1007/s00125-018-4711-2
   Holscher HD, 2017, GUT MICROBES, V8, P172, DOI 10.1080/19490976.2017.1290756
   Kim CH, 2018, CELL MOL IMMUNOL, V15, P88, DOI 10.1038/cmi.2017.57
   Larraufie P, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-017-18259-0
   Lee ES, 2018, FOOD HYDROCOLLOID, V75, P22, DOI 10.1016/j.foodhyd.2017.09.019
   Li KK, 2017, J FUNCT FOODS, V38, P561, DOI 10.1016/j.jff.2017.09.049
   Liang Y, 2016, PROBIOTICS ANTIMICRO, V6, P37589
   Liu GM, 2018, INT J BIOL MACROMOL, V115, P711, DOI 10.1016/j.ijbiomac.2018.04.127
   Lyte M, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0146406
   Meng D.-L., 2018, CHINESE J NEW CLIN M, V11, P198
   Pang SQ, 2020, J INTEGR NEUROSCI, V19, P273, DOI 10.31083/j.jin.2020.02.69
   Pang ShuQin, 2017, Zhongguo Shiyong Neike Zazhi / Chinese Journal of Practical Internal Medicine, V37, P247
   [彭浩 Peng Hao], 2016, [中华中医药杂志, China Journal of Traditional Chinese Medicine and Pharmacy], V31, P4076
   Psichas A, 2015, INT J OBESITY, V39, P424, DOI 10.1038/ijo.2014.153
   Sabico S, 2017, J TRANSL MED, V15, DOI 10.1186/s12967-017-1354-x
   Sedighi M, 2017, MICROB PATHOGENESIS, V111, P362, DOI 10.1016/j.micpath.2017.08.038
   Shao LM, 2017, ACTA CHINESE MED PHA, V45, P125
   Wang XL, 2015, NANOTECHNOLOGY, V26, DOI 10.1088/0957-4484/26/14/145705
   Yu F L, 2017, Zhonghua Liu Xing Bing Xue Za Zhi, V38, P602, DOI 10.3760/cma.j.issn.0254-6450.2017.05.009
   Yuan Y, 2019, J AGR FOOD CHEM, V67, P12472, DOI 10.1021/acs.jafc.9b05118
   Zhang N, 2019, FOOD RES INT, V122, P191, DOI 10.1016/j.foodres.2019.04.016
   Zhang Q, 2018, PEERJ, V6, DOI 10.7717/peerj.4446
   Zhang XC, 2018, RECORDS TRADITIONAL
   Zhao LiHui, 2016, Zhongguo Weishengtaxixue Zazhi / Chinese Journal of Microecology, V28, P1110
   Zhao LP, 2018, SCIENCE, V359, P1151, DOI 10.1126/science.aao5774
NR 35
TC 2
Z9 5
U1 8
U2 16
PU DE GRUYTER POLAND SP Z O O
PI WARSAW
PA BOGUMILA ZUGA 32A STR, 01-811 WARSAW, MAZOVIA, POLAND
SN 2391-5412
J9 OPEN LIFE SCI
JI Open Life Sci.
PY 2020
VL 15
IS 1
BP 763
EP 773
DI 10.1515/biol-2020-0096
PG 11
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA OP8YU
UT WOS:000588377600001
PM 33817264
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Lin, R
   He, X
   Chen, HF
   He, Q
   Yao, ZT
   Li, YF
   Yang, H
   Simpson, S
AF Lin, Rui
   He, Xuan
   Chen, Huafeng
   He, Qin
   Yao, Ziting
   Li, Yuanfan
   Yang, Hui
   Simpson, Steve, Jr.
TI Oil tea improves glucose and lipid levels and alters gut microbiota in
   type 2 diabetic mice
SO NUTRITION RESEARCH
LA English
DT Article
DE Oil tea; Glucose; Lipid; Gut microbiota; Type 2 diabetes; db/db mice
ID GINGER ZINGIBER-OFFICINALE; GREEN TEA; METAANALYSIS; OBESITY;
   CONSUMPTION; MELLITUS; RISK
AB Oil tea has traditionally been used in minority populations in China for treating various ailments in traditional Chinese medicine. Individually, green tea and ginger, which are the main ingredients of oil tea, have demonstrated antidiabetic effects; however, whether oil tea exerts antidiabetic effects remains unknown. In addition, aberrant gut microbiota structure is associated with diabetic status, and research indicates that there may be beneficial effects of tea on gut microbiota. Therefore, we hypothesized that oil tea exerts antidiabetic effects and induces alteration in gut microbiota. To test our hypothesis, we first examined the nutrition composition of oil tea. Then, db/db mice were randomly divided into 3 groups and orally gavaged with saline, metformin, and oil tea for 8 weeks. Fasting blood glucose (FBG), oral glucose tolerance test (OGTT), and lipid levels were tested during the experiment. 16S rRNA genes were sequenced and changes in gut microbiota in response pre/post treatment were examined. Our experiments showed that oil tea contains high concentrations of tea polyphenols (246.35 mg/100 g) and [6]-gingerol (2.98 mg/100 g). It appeared that oil tea treatment significantly suppressed the postprandial blood glucose elevation and lowered the levels of FBG, total cholesterol, triglycerides, and LDL-cholesterol (P < .05). The composition of gut microbiota changed significantly in response to oil tea treatment, Lachnospiraceae were significantly enriched (q < 0.05, LDA score> 3.5). Redundancy analysis identified 155 oil tea-modulating family level phylotypes, where Lachnospiraceae significantly correlated with FBG, total cholesterol, and LDL-cholesterol (P < .05). Our findings demonstrate that oil tea improved glucose and lipid levels and modulated gut microbiota in db/db mice. (C) 2018 Elsevier Inc. All rights reserved.
C1 [Lin, Rui; Yao, Ziting; Li, Yuanfan] Guangxi Med Univ, Ctr Genom & Personalized Med, 22 Shuangyong Rd, Nanning 530021, Guangxi, Peoples R China.
   [Lin, Rui; He, Xuan; Chen, Huafeng; He, Qin; Yang, Hui] Guangxi Ctr Dis Prevent & Control, Nanning, Peoples R China.
   [Simpson, Steve, Jr.] Univ Melbourne, Melbourne Sch Populat Global Hlth, Carlton, Vic, Australia.
   [Simpson, Steve, Jr.] Univ Tasmania, Menzies Inst Med Res, Hobart, Tas, Australia.
C3 Guangxi Medical University; University of Melbourne; University of
   Tasmania; Menzies Institute for Medical Research
RP Lin, R (通讯作者)，Guangxi Med Univ, Ctr Genom & Personalized Med, 22 Shuangyong Rd, Nanning 530021, Guangxi, Peoples R China.
EM linrui@gxmu.edu.cn
RI Lin, Rui/P-2742-2019; Simpson, Steve Jr/J-2454-2013
OI Lin, Rui/0000-0002-3846-9301; Simpson, Steve Jr/0000-0001-6521-3056
FU National Natural Science Foundation of China [81660540]; Guangxi Natural
   Science Foundation [2015GXNSFCA139010]; Technology Foundation for
   Selected Overseas Chinese Scholar, Ministry of Personnel of China
   [[2016] 176]
FX This work was supported by the National Natural Science Foundation of
   China (No.81660540), Guangxi Natural Science Foundation (Grant No.
   2015GXNSFCA139010), and Technology Foundation for Selected Overseas
   Chinese Scholar, Ministry of Personnel of China (No. [2016] 176). The
   authors declare that they have no conflicts of interest.
CR Abdulrazaq NB, 2012, BRIT J NUTR, V108, P1194, DOI 10.1017/S0007114511006635
   Akash MSH, 2015, CRIT REV EUKAR GENE, V25, P91, DOI 10.1615/CritRevEukaryotGeneExpr.2015013358
   Aschner Judy L., 2005, Molecular Aspects of Medicine, V26, P353, DOI 10.1016/j.mam.2005.07.003
   Bae KC, 2013, DIABETES METAB J, V37, P196, DOI 10.4093/dmj.2013.37.3.196
   Bin Samad M, 2017, BMC COMPLEM ALTERN M, V17, DOI 10.1186/s12906-017-1903-0
   Bode A.M., 2011, HERBAL MED BIOMOLECU
   Chen GJ, 2018, MOL NUTR FOOD RES, V62, DOI 10.1002/mnfr.201700485
   Cheng M, 2018, FOOD FUNCT, V9, P1079, DOI [10.1039/c7fo01570d, 10.1039/C7FO01570D]
   Cho I, 2012, NATURE, V488, P621, DOI 10.1038/nature11400
   David LA, 2014, NATURE, V505, P559, DOI 10.1038/nature12820
   Edgar RC, 2013, NAT METHODS, V10, P996, DOI [10.1038/nmeth.2604, 10.1038/NMETH.2604]
   Faul F, 2007, BEHAV RES METHODS, V39, P175, DOI 10.3758/BF03193146
   Federico A, 2017, MINERVA GASTROENTERO, V63, P337, DOI 10.23736/S1121-421X.17.02376-5
   Hong X, 2015, J MED PHARM CHIN MIN, V21, P75
   Hou X, 2017, J MED PHARM CHIN MIN, P1
   Hur KY, 2015, DIABETES METAB J, V39, P198, DOI 10.4093/dmj.2015.39.3.198
   Jan S, 2014, MULTIVARIATE ANAL EC
   Jing YL, 2009, J GEN INTERN MED, V24, P557, DOI 10.1007/s11606-009-0929-5
   Kadnur Sanjay V., 2005, Indian Journal of Experimental Biology, V43, P1161
   Kang SJ, 2014, NUTRIENTS, V6, P3536, DOI 10.3390/nu6093536
   Khunti K, 2018, DIABETES OBES METAB, V20, P1337, DOI 10.1111/dom.13243
   Koren O, 2011, P NATL ACAD SCI USA, V108, P4592, DOI 10.1073/pnas.1011383107
   Li S, 2013, COMPENDIUM MAT MED
   Li S, 2013, CHIN J NAT MEDICINES, V11, P110, DOI [10.1016/S1875-5364(13)60037-0, 10.3724/SP.J.1009.2013.00110]
   Liu K, 2013, AM J CLIN NUTR, V98, P340, DOI 10.3945/ajcn.112.052746
   Liu ZY, 2015, MED J QILU, V30, P677
   Ministry of Health of the People's Republic of China, 1997, GBT541331997 MIN HLT
   Ministry of Health of the People's Republic of China, 2010, GBT500932010 MIN HLT
   Ministry of Health of the People's Republic of China, 2013, GBT83122013 MIN HLTH
   Ministry of Health of the People's Republic of China, 2003, GBT50092003 MIN HLTH
   Ministry of Health of the People's Republic of China, 2010, GBT500952010 MIN HLT
   Ministry of Health of the People's Republic of China, 2010, GBT500942010 MIN HLT
   Ministry of Health of the People's Republic of China, 2011, GBT280502011 MIN HLT
   Ministry of Health of the People's Republic of China, 2008, GBT5009882008 MIN HL
   Ministry of Health of the People's Republic of China, 2003, GBT50091592003 MIN H
   Ministry of Health of the People's Republic of China, 2008, GBT83122008 MIN HLTH
   Mozaffari-Khosravi H, 2014, COMPLEMENT THER MED, V22, P9, DOI 10.1016/j.ctim.2013.12.017
   Nicoll R, 2009, INT J CARDIOL, V131, P408, DOI 10.1016/j.ijcard.2007.07.107
   Ortsater H, 2012, NUTR METAB, V9, DOI 10.1186/1743-7075-9-11
   Pei EL, 2014, J DIABETES COMPLICAT, V28, P559, DOI 10.1016/j.jdiacomp.2014.04.002
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Schloss PD, 2009, APPL ENVIRON MICROB, V75, P7537, DOI 10.1128/AEM.01541-09
   Sedighi M, 2017, MICROB PATHOGENESIS, V111, P362, DOI 10.1016/j.micpath.2017.08.038
   Segata N, 2011, GENOME BIOL, V12, DOI 10.1186/gb-2011-12-6-r60
   Seo DB, 2015, J MED FOOD, V18, P549, DOI 10.1089/jmf.2014.3265
   Siddiqui K, 2014, SCI WORLD J, DOI 10.1155/2014/461591
   Somineni HK, 2014, J ENDOCRINOL, V221, P235, DOI 10.1530/JOE-13-0532
   Son MJ, 2015, CYTOTECHNOLOGY, V67, P641, DOI 10.1007/s10616-014-9730-3
   Tang ZZ, 2016, INT J ENV RES PUB HE, V13, DOI 10.3390/ijerph13100976
   Tsuneki Hiroshi, 2004, BMC Pharmacology, V4, P18, DOI 10.1186/1471-2210-4-18
   Vanegas SM, 2017, AM J CLIN NUTR, V105, P635, DOI 10.3945/ajcn.116.146928
   Wein S, 2013, J MED FOOD, V16, P312, DOI 10.1089/jmf.2012.0205
   Xu S.Y, 2002, METHODOLOGY PHARM EX
   Xu Y, 2013, JAMA-J AM MED ASSOC, V310, P948, DOI 10.1001/jama.2013.168118
   Yang WS, 2014, BRIT J NUTR, V111, P1329, DOI 10.1017/S0007114513003887
NR 55
TC 28
Z9 30
U1 6
U2 76
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0271-5317
EI 1879-0739
J9 NUTR RES
JI Nutr. Res.
PD SEP
PY 2018
VL 57
BP 67
EP 77
DI 10.1016/j.nutres.2018.05.004
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA GS3PH
UT WOS:000443531500007
PM 30122197
DA 2023-06-08
ER

PT J
AU Loomba, R
   Seguritan, V
   Li, WZ
   Long, T
   Klitgord, N
   Bhatt, A
   Dulai, PS
   Caussy, C
   Bettencourt, R
   Highlander, SK
   Jones, MB
   Sirlin, CB
   Schnabl, B
   Brinkac, L
   Schork, N
   Chen, CH
   Brenner, DA
   Biggs, W
   Yooseph, S
   Venter, JC
   Nelson, KE
AF Loomba, Rohit
   Seguritan, Victor
   Li, Weizhong
   Long, Tao
   Klitgord, Niels
   Bhatt, Archana
   Dulai, Parambir Singh
   Caussy, Cyrielle
   Bettencourt, Richele
   Highlander, Sarah K.
   Jones, Marcus B.
   Sirlin, Claude B.
   Schnabl, Bernd
   Brinkac, Lauren
   Schork, Nicholas
   Chen, Chi-Hua
   Brenner, David A.
   Biggs, William
   Yooseph, Shibu
   Venter, J. Craig
   Nelson, Karen E.
TI Gut Microbiome-Based Metagenomic Signature for Non-invasive Detection of
   Advanced Fibrosis in Human Nonalcoholic Fatty Liver Disease
SO CELL METABOLISM
LA English
DT Article
ID NATURAL-HISTORY; HEPATIC STEATOSIS; DYSBIOSIS; NAFLD; STEATOHEPATITIS;
   PROGRESSION; EPIDEMIOLOGY; METFORMIN; CIRRHOSIS; PROFILE
AB The presence of advanced fibrosis in nonalcoholic fatty liver disease (NAFLD) is the most important predictor of liver mortality. There are limited data on the diagnostic accuracy of gut microbiota-derived signature for predicting the presence of advanced fibrosis. In this prospective study, we characterized the gut microbiome compositions using wholegenome shotgun sequencing of DNA extracted from stool samples. This study included 86 uniquely well-characterized patients with biopsy-proven NAFLD, of which 72 had mild/moderate (stage 0-2 fibrosis) NAFLD, and 14 had advanced fibrosis (stage 3 or 4 fibrosis). We identified a set of 40 features (p < 0.006), which included 37 bacterial species that were used to construct a Random Forest classifier model to distinguish mild/moderate NAFLD from advanced fibrosis. The model had a robust diagnostic accuracy (AUC 0.936) for detecting advanced fibrosis. This study provides preliminary evidence for a fecal-microbiome-derived metagenomic signature to detect advanced fibrosis in NAFLD.
C1 [Loomba, Rohit; Bhatt, Archana; Dulai, Parambir Singh; Caussy, Cyrielle; Bettencourt, Richele; Schnabl, Bernd; Brenner, David A.] Univ Calif San Diego, NAFLD Res Ctr, Dept Med, La Jolla, CA 92093 USA.
   [Loomba, Rohit] Univ Calif San Diego, Div Epidemiol, Dept Family & Prevent Med, La Jolla, CA 92093 USA.
   [Loomba, Rohit; Dulai, Parambir Singh; Schnabl, Bernd; Brenner, David A.] Univ Calif San Diego, Div Gastroenterol, Dept Med, La Jolla, CA 92093 USA.
   [Seguritan, Victor; Li, Weizhong; Long, Tao; Klitgord, Niels; Jones, Marcus B.; Biggs, William; Yooseph, Shibu; Venter, J. Craig; Nelson, Karen E.] Human Longev, San Diego, CA 92121 USA.
   [Li, Weizhong; Highlander, Sarah K.; Schork, Nicholas; Yooseph, Shibu; Venter, J. Craig; Nelson, Karen E.] J Craig Venter Inst, La Jolla, CA 92037 USA.
   [Sirlin, Claude B.; Chen, Chi-Hua] Univ Calif San Diego, Dept Radiol, Liver Imaging Grp, La Jolla, CA 92093 USA.
   [Brinkac, Lauren] J Craig Venter Inst, Rockville, MD 20850 USA.
C3 University of California System; University of California San Diego;
   University of California System; University of California San Diego;
   University of California System; University of California San Diego; J.
   Craig Venter Institute; University of California System; University of
   California San Diego; J. Craig Venter Institute
RP Loomba, R (通讯作者)，Univ Calif San Diego, NAFLD Res Ctr, Dept Med, La Jolla, CA 92093 USA.; Loomba, R (通讯作者)，Univ Calif San Diego, Div Epidemiol, Dept Family & Prevent Med, La Jolla, CA 92093 USA.; Loomba, R (通讯作者)，Univ Calif San Diego, Div Gastroenterol, Dept Med, La Jolla, CA 92093 USA.
EM roloomba@ucsd.edu
RI Dulai, Parambir/AAE-2983-2021; Sirlin, Claude/AAU-1376-2020; Loomba,
   Rohit/AAE-7831-2019; Dulai, Parambir/AAF-4408-2020; Li,
   Weizhong/A-9735-2008; Carmen, Team2/Y-7383-2019
OI Sirlin, Claude/0000-0002-6639-9072; Loomba, Rohit/0000-0002-4845-9991;
   Li, Weizhong/0000-0003-1804-9403; Carmen, Team2/0000-0001-9867-5724;
   Schork, Nicholas/0000-0003-0920-5013; Brenner,
   David/0000-0003-2573-525X; Lab, Carmen/0000-0002-5935-3236; Long,
   Tao/0000-0002-7052-9546; Yooseph, Shibu/0000-0001-5581-5002
FU American Gastroenterological Association (AGA) Foundation - Sucampo -
   ASP Designated Research Award in Geriatric Gastroenterology; T. Franklin
   Williams Scholarship Award; National Institute of Diabetes and Digestive
   and Kidney Diseases (NIDDK) [5T32DK007202]; Atlantic Philanthropies;
   John A. Hartford Foundation, OM; Association of Specialty Professors;
   American Gastroenterological Association [K23DK090303]; Human Longevity;
   National Institute of Environmental Health Sciences of the NIH
   [P42ES010337]
FX The authors are grateful to Alan Hofmann, MD for his insightful comments
   and suggestions. The study was conducted at the Clinical and
   Translational Research Institute, University of California at San Diego.
   R.L. is supported in part by the American Gastroenterological
   Association (AGA) Foundation - Sucampo - ASP Designated Research Award
   in Geriatric Gastroenterology and by a T. Franklin Williams Scholarship
   Award. P.S.D. is supported in part by the National Institute of Diabetes
   and Digestive and Kidney Diseases (NIDDK) training grant 5T32DK007202.
   Funding provided by Atlantic Philanthropies, the John A. Hartford
   Foundation, OM, the Association of Specialty Professors, and the
   American Gastroenterological Association, grant K23DK090303. The
   microbiome sequencing was performed and funded by Human Longevity.
   Research reported in this publication was supported by the National
   Institute of Environmental Health Sciences of the NIH under award number
   P42ES010337. The content is solely the responsibility of the authors and
   does not necessarily represent the official views of the NIH. Funding
   agencies did not have any role in the design and conduct of the study,
   collection, management, analysis, or interpretation of the data;
   preparation, review, or approval of the manuscript. The genomic
   sequencing data underlying this manuscript were generated solely with
   private funding.
CR Adams LA, 2005, GASTROENTEROLOGY, V129, P113, DOI 10.1053/j.gastro.2005.04.014
   Affo S, 2014, GUT, V63, P1782, DOI 10.1136/gutjnl-2013-306098
   Anand G, 2016, SEMIN LIVER DIS, V36, P37, DOI 10.1055/s-0035-1571276
   Angulo P, 2015, GASTROENTEROLOGY, V149, P389, DOI 10.1053/j.gastro.2015.04.043
   Bai L, 2016, MOL MED REP, V13, P3835, DOI 10.3892/mmr.2016.5003
   Bajaj JS, 2014, J HEPATOL, V60, P940, DOI 10.1016/j.jhep.2013.12.019
   Betrapally NS, 2016, GASTROENTEROLOGY, V150, P1745, DOI 10.1053/j.gastro.2016.02.073
   Bhala N, 2011, HEPATOLOGY, V54, P1208, DOI 10.1002/hep.24491
   Boursier J, 2016, HEPATOLOGY, V63, P764, DOI 10.1002/hep.28356
   Breiman L., 2001, Machine Learning, V45, P5, DOI 10.1023/A:1010933404324
   Chen YM, 2016, SCI REP-UK, V6, DOI 10.1038/srep19076
   Cui J, 2016, HEPATOLOGY, V64, P1547, DOI 10.1002/hep.28674
   DeMinicis S, 2014, HEPATOLOGY, V59, P1738, DOI 10.1002/hep.26695
   Decaris ML, 2017, HEPATOLOGY, V65, P78, DOI 10.1002/hep.28860
   Dulai P. S., 2017, HEPATOLOGY
   Dulai PS, 2016, J HEPATOL, V65, P1006, DOI 10.1016/j.jhep.2016.06.005
   Ekstedt M, 2015, HEPATOLOGY, V61, P1547, DOI 10.1002/hep.27368
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Gill SR, 2006, SCIENCE, V312, P1355, DOI 10.1126/science.1124234
   Guo LN, 2015, P NATL ACAD SCI USA, V112, pE4901, DOI 10.1073/pnas.1508425112
   Henao-Mejia J, 2012, NATURE, V482, P179, DOI 10.1038/nature10809
   Jones MB, 2015, P NATL ACAD SCI USA, V112, P14024, DOI 10.1073/pnas.1519288112
   Kakiyama G, 2013, J HEPATOL, V58, P949, DOI 10.1016/j.jhep.2013.01.003
   Karp Peter D, 2002, Bioinformatics, V18 Suppl 1, pS225
   Kleiner DE, 2005, HEPATOLOGY, V41, P1313, DOI 10.1002/hep.20701
   Lelouvier B, 2016, HEPATOLOGY, V64, P2015, DOI 10.1002/hep.28829
   Liu HL, 2016, J LIPID RES, V57, P1831, DOI 10.1194/jlr.M069807
   Loomba R, 2015, GASTROENTEROLOGY, V149, P1784, DOI 10.1053/j.gastro.2015.08.011
   Loomba R, 2013, NAT REV GASTRO HEPAT, V10, P686, DOI 10.1038/nrgastro.2013.171
   Mardinoglu A, 2016, CELL METAB, V23, P10, DOI 10.1016/j.cmet.2015.12.012
   Matteoni CA, 1999, GASTROENTEROLOGY, V116, P1413, DOI 10.1016/S0016-5085(99)70506-8
   MOSS CW, 1970, APPL MICROBIOL, V19, P375, DOI 10.1128/AEM.19.2.375-378.1970
   Nelson KE, 2010, SCIENCE, V328, P994, DOI 10.1126/science.1183605
   Noguchi H, 2006, NUCLEIC ACIDS RES, V34, P5623, DOI 10.1093/nar/gkl723
   Qin N, 2014, NATURE, V513, P59, DOI 10.1038/nature13568
   Rinella ME, 2015, JAMA-J AM MED ASSOC, V313, P2263, DOI 10.1001/jama.2015.5370
   Seki E, 2007, NAT MED, V13, P1324, DOI 10.1038/nm1663
   Singh S, 2015, CLIN GASTROENTEROL H, V13, P643, DOI 10.1016/j.cgh.2014.04.014
   Turnbaugh PJ, 2009, NATURE, V457, P480, DOI 10.1038/nature07540
   Vernon G, 2011, ALIMENT PHARM THER, V34, P274, DOI 10.1111/j.1365-2036.2011.04724.x
   Wikoff WR, 2009, P NATL ACAD SCI USA, V106, P3698, DOI 10.1073/pnas.0812874106
   Wong VWS, 2010, GUT, V59, P969, DOI 10.1136/gut.2009.205088
   Younossi ZM, 2016, HEPATOLOGY, V64, P73, DOI 10.1002/hep.28431
   Zarrinpar A, 2016, GUT, V65, P1546, DOI 10.1136/gutjnl-2015-309456
   Zhu LX, 2013, HEPATOLOGY, V57, P601, DOI 10.1002/hep.26093
NR 45
TC 508
Z9 529
U1 10
U2 151
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
SN 1550-4131
EI 1932-7420
J9 CELL METAB
JI Cell Metab.
PD MAY 2
PY 2017
VL 25
IS 5
BP 1054
EP +
DI 10.1016/j.cmet.2017.04.001
PG 14
WC Cell Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Endocrinology & Metabolism
GA ET6JM
UT WOS:000400397900014
PM 28467925
OA Green Submitted, Bronze, Green Accepted
HC Y
HP N
DA 2023-06-08
ER

PT J
AU van den Bosch, MHJ
AF van den Bosch, M. H. J.
TI Osteoarthritis year in review 2020: biology
SO OSTEOARTHRITIS AND CARTILAGE
LA English
DT Review
DE Osteoarthritis; Biology; Cartilage; Synovium; Inflammation
ID ACTIVATED PROTEIN-KINASE; STEM-CELLS; ATTENUATES OSTEOARTHRITIS;
   CARTILAGE DEGENERATION; MICROBIOME COMPOSITION; ADIPOSE; MACROPHAGES;
   CHONDROCYTES; METFORMIN; KNEE
AB This year in review about osteoarthritis biology highlights a selection of articles published between the 2019 and 2020 Osteoarthritis Research Society International (OARSI) World Congress meetings, within the field of osteoarthritis biology. Highlights were selected from PubMed searches covering osteoarthritis (OA) cartilage, subchondral bone, synovium and aging. Subsequently, a personal selection was based on new and emerging themes together with common research topics that were studied by multiple groups. Themes discussed include novel insights into the inflammatory changes during OA, with a number of noteworthy publications concerning the role of macrophages in healthy and osteoarthritic joints. Next, the application of mesenchymal stem cells as OA-dampening therapy is discussed, including possible ways to improve their efficacy by pre-treatment. Other significant themes including treatment of OA with metformin, enhancing autophagy to alleviate OA and the involvement of the gastro-intestinal microbiome in development of OA symptoms and structural damage are discussed. An effort was made to connect the seemingly distant topics from which the overarching conclusion can be drawn that over the last year promising breakthroughs have been achieved in further understanding the biology of OA development and that new therapeutic possibilities have been explored. (c) 2020 The Author(s). Published by Elsevier Ltd on behalf of Osteoarthritis Research Society International.
C1 [van den Bosch, M. H. J.] Radboud Univ Nijmegen, Med Ctr, Expt Rheumatol, Geert Grooteplein 28, NL-6525 GA Nijmegen, Netherlands.
C3 Radboud University Nijmegen
RP van den Bosch, MHJ (通讯作者)，Radboud Univ Nijmegen, Med Ctr, Expt Rheumatol, Geert Grooteplein 28, NL-6525 GA Nijmegen, Netherlands.
EM martijn.vandenbosch@radboudumc.nl
RI van den Bosch, Martijn HJ/D-7933-2016
OI van den Bosch, Martijn HJ/0000-0001-8074-826X
FU ZonMW/VENI research program [09150161810015]; Dutch Research Council
   (NWO)
FX The author acknowledges funding from the ZonMW/VENI research program
   (project number 09150161810015), which is financed by the Dutch Research
   Council (NWO).
CR Bailey KN, 2020, OSTEOARTHR CARTILAGE, V28, P626, DOI 10.1016/j.joca.2020.01.015
   Barreto G, 2020, OSTEOARTHR CARTILAGE, V28, P92, DOI 10.1016/j.joca.2019.10.011
   Berenbaum F, 2011, ANN RHEUM DIS, V70, P1354, DOI 10.1136/ard.2010.146399
   Blom AB, 2004, OSTEOARTHR CARTILAGE, V12, P627, DOI 10.1016/j.joca.2004.03.003
   Blom AB, 2007, ARTHRITIS RHEUM, V56, P147, DOI 10.1002/art.22337
   Boer CG, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-12873-4
   Burnett SH, 2004, J LEUKOCYTE BIOL, V75, P612, DOI 10.1189/jlb.0903442
   Camacho-Encina M, 2019, ANN RHEUM DIS, V78, P1699, DOI 10.1136/annrheumdis-2019-215325
   Chen WB, 2019, J TISSUE ENG REGEN M, V13, P1618, DOI 10.1002/term.2916
   Culemann S, 2019, NATURE, V572, P670, DOI 10.1038/s41586-019-1471-1
   Desando G, 2013, ARTHRITIS RES THER, V15, DOI 10.1186/ar4156
   Deshmukh V, 2019, OSTEOARTHR CARTILAGE, V27, P1347, DOI 10.1016/j.joca.2019.05.006
   Feng XF, 2020, AGING-US, V12, P1087, DOI 10.18632/aging.102635
   Frey N, 2016, OSTEOARTHR CARTILAGE, V24, P1535, DOI 10.1016/j.joca.2016.04.005
   Grandi FC, 2020, SCI ADV, V6, DOI 10.1126/sciadv.aay5352
   Gupta VK, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.01162
   Hu Y, 2019, FREE RADICAL BIO MED, V145, P146, DOI 10.1016/j.freeradbiomed.2019.09.024
   Huang ZY, 2016, OSTEOARTHR CARTILAGE, V24, P1769, DOI 10.1016/j.joca.2016.05.008
   Huang ZY, 2020, ANN RHEUM DIS, V79, P646, DOI 10.1136/annrheumdis-2019-216471
   Klein-Wieringa IR, 2016, J RHEUMATOL, V43, P771, DOI 10.3899/jrheum.151068
   Ko JY, 2019, TISSUE ENG PT A, V25, P990, DOI [10.1089/ten.tea.2018.0189, 10.1089/ten.TEA.2018.0189]
   Kong CY, 2020, BIOCHEM CELL BIOL, V98, P434, DOI 10.1139/bcb-2019-0333
   Li H, 2020, ARTHRITIS RES THER, V22, DOI 10.1186/s13075-020-2129-y
   Li J, 2020, ANN RHEUM DIS, V79, P635, DOI 10.1136/annrheumdis-2019-216713
   Liang HZ, 2019, LIFE SCI, V228, P258, DOI 10.1016/j.lfs.2019.04.011
   Liao FX, 2021, CARTILAGE, V13, p1237S, DOI 10.1177/1947603519847736
   Louati K, 2015, RMD OPEN, V1, DOI 10.1136/rmdopen-2015-000077
   Lu CH, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0191242
   Mahon OR, 2020, OSTEOARTHR CARTILAGE, V28, P603, DOI 10.1016/j.joca.2019.10.010
   Manferdini C, 2020, J ORTHOP RES, V38, P336, DOI 10.1002/jor.24446
   Manferdini C, 2016, ARTHRITIS RES THER, V18, DOI 10.1186/s13075-016-0983-4
   Manferdini C, 2013, ARTHRITIS RHEUM-US, V65, P1271, DOI 10.1002/art.37908
   Maruthur NM, 2016, ANN INTERN MED, V164, P740, DOI 10.7326/M15-2650
   Niada S, 2019, STEM CELL RES, V38, DOI 10.1016/j.scr.2019.101463
   Park MJ, 2019, J IMMUNOL, V203, P127, DOI 10.4049/jimmunol.1800006
   Pers YM, 2016, STEM CELL TRANSL MED, V5, P847, DOI 10.5966/sctm.2015-0245
   Petursson F, 2013, ARTHRITIS RES THER, V15, DOI 10.1186/ar4254
   Ragni E, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21051582
   Rena G, 2017, DIABETOLOGIA, V60, P1577, DOI 10.1007/s00125-017-4342-z
   Rosa SC, 2009, ARTHRITIS RES THER, V11, DOI 10.1186/ar2713
   Schelbergen RF, 2014, OSTEOARTHR CARTILAGE, V22, P1158, DOI 10.1016/j.joca.2014.05.022
   ter Huurne M, 2012, ARTHRITIS RHEUM-US, V64, P3604, DOI 10.1002/art.34626
   Terkeltaub R, 2011, ARTHRITIS RHEUM-US, V63, P1928, DOI 10.1002/art.30333
   van Dalen SCM, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.01075
   Van den Bossche J, 2017, TRENDS IMMUNOL, V38, P395, DOI 10.1016/j.it.2017.03.001
   Wang YY, 2019, ARTHRITIS RES THER, V21, DOI 10.1186/s13075-019-1915-x
   Wu CL, 2017, ARTHRITIS RHEUMATOL, V69, P1772, DOI 10.1002/art.40161
   Yazici Y, 2020, ARTHRITIS RHEUMATOL, V72, P1694, DOI 10.1002/art.41315
   Zhong G, 2019, NANOSCALE, V11, P11605, DOI 10.1039/c9nr03060c
   Zhou F, 2020, ACS APPL MATER INTER, V12, P2009, DOI 10.1021/acsami.9b16327
   Zhou F, 2019, ACTA PHARM SIN B, V9, P973, DOI 10.1016/j.apsb.2019.01.015
   Zhou GC, 2001, J CLIN INVEST, V108, P1167, DOI 10.1172/JCI200113505
   Zhou S, 2017, SCI REP-UK, V7, P1, DOI 10.1038/srep43245
   Zinocker MK, 2018, NUTRIENTS, V10, DOI 10.3390/nu10030365
NR 54
TC 70
Z9 70
U1 30
U2 156
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1063-4584
EI 1522-9653
J9 OSTEOARTHR CARTILAGE
JI Osteoarthritis Cartilage
PD FEB
PY 2021
VL 29
IS 2
BP 143
EP 150
DI 10.1016/j.joca.2020.10.006
EA FEB 2021
PG 8
WC Orthopedics; Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Rheumatology
GA QE5UG
UT WOS:000616271700001
PM 33242602
OA Green Published, hybrid
HC Y
HP N
DA 2023-06-08
ER

PT J
AU Van Nieuwenhove, T
   Rasschaert, G
   Kharagjitsingh, A
   Keymeulen, B
   Reynaert, H
   Kindt, S
AF Van Nieuwenhove, T.
   Rasschaert, G.
   Kharagjitsingh, A.
   Keymeulen, B.
   Reynaert, H.
   Kindt, S.
TI The prevalence of disorders of the gut-brain axis in type 2 diabetes
   mellitus patients with metabolic dysfunction-associated fatty liver
   disease: an observational study
SO ACTA GASTRO-ENTEROLOGICA BELGICA
LA English
DT Article
DE metabolic dysfunction-associated fatty liver disease; irritable bowel
   syndrome; type 2 diabetes; disorders of the gut-brain axis
ID IRRITABLE-BOWEL-SYNDROME; GASTROINTESTINAL SYMPTOMS; NONALCOHOLIC
   STEATOHEPATITIS; FECAL MICROBIOTA; GLYCEMIC CONTROL; ABDOMINAL-PAIN;
   LIFE; EPIDEMIOLOGY; METAANALYSIS; DEPRESSION
AB Background and study aim: Disorders of the gut-brain axis (DGBI) and metabolic dysfunction-associated liver disease (MAFLD) are frequently diagnosed and exhibit pathophysiological similarities. This study aimed to estimate the prevalence of DGBI in type 2 diabetes mellitus (T2DM) patients with MAFLD. Patients and methods: In this single center, observational study, in adults with T2DM demographics, diabetes-related parameters and liver tests were recorded. MAFLD was defined by the presence of hepatic steatosis on imaging. Functional dyspepsia (FD) and irritable bowel syndrome (IBS) were diagnosed based on Rome IV criteria. Quality of life (QOL), anxiety levels and depression levels were documented by validated questionnaires. Results: We included 77 patients, 44 with and 33 without steatosis. There were no significant differences in age, body mass index (BMI), waist circumference, HbA1c levels or metformin use between groups. IBS was significantly more prevalent in the liver steatosis group (9/44 vs. 2/33, p = .037), while a similar trend was observed for FD (9/35 vs. 2/31, p = .103). No differences were found in anxiety, depression and overall QOL. However, QOL subscales for health worry, food avoidance and social reaction were significantly higher in the liver steatosis group. Conclusions: In otherwise comparable T2DM patients, DGBI, and especially IBS, are more prevalent in the presence of MAFLD. This difference could not be attributed to increased levels of anxiety or depression. Future research should target the underlying pathophysiological mechanisms. (Acta gastroenterol. belg., 2021, 84, 541-547).
C1 [Van Nieuwenhove, T.; Rasschaert, G.; Reynaert, H.; Kindt, S.] Vrije Univ Brussel VUB, Univ Ziekenhuis Brussel UZ Brussel, Dept Gastroenterol, Laarbeeklaan 101, B-1090 Brussels, Belgium.
   [Kharagjitsingh, A.; Keymeulen, B.] Vrije Univ Brussel VUB, Univ Ziekenhuis Brussel UZ Brussel, Dept Diabet & Endocrinol, Laarbeeklaan 101, B-1090 Brussels, Belgium.
C3 University Hospital Brussels; Vrije Universiteit Brussel; University
   Hospital Brussels; Vrije Universiteit Brussel
RP Kindt, S (通讯作者)，UZ Brussel, Deparment Gastroenterol, Laerbeeklaan 101, B-1090 Brussels, Belgium.
EM sebastien.kindt@uzbrussel.be
OI Reynaert, Hendrik/0000-0002-2701-5777; Keymeulen,
   Bart/0000-0002-8671-4527
CR Anitha M, 2012, GASTROENTEROLOGY, V143, P1006, DOI 10.1053/j.gastro.2012.06.034
   Bajaj JS, 2014, J HEPATOL, V60, P940, DOI 10.1016/j.jhep.2013.12.019
   Barbara G, 2004, GASTROENTEROLOGY, V126, P693, DOI 10.1053/j.gastro.2003.11.055
   Bellentani S, 2017, LIVER INT, V37, P81, DOI 10.1111/liv.13299
   Bonfrate L, 2020, EUR J CLIN INVEST, V50, DOI 10.1111/eci.13201
   Bruewer M, 2003, J IMMUNOL, V171, P6164, DOI 10.4049/jimmunol.171.11.6164
   Brun P, 2007, AM J PHYSIOL-GASTR L, V292, pG518, DOI 10.1152/ajpgi.00024.2006
   Bytzer P, 2002, AM J GASTROENTEROL, V97, P604
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   Chandrasekharan B, 2007, NEUROGASTROENT MOTIL, V19, P951, DOI 10.1111/j.1365-2982.2007.01023.x
   Choudhary NS, 2015, J CLIN EXP HEPATOL, V5, P123, DOI 10.1016/j.jceh.2015.04.002
   Cremon C, 2011, AM J GASTROENTEROL, V106, P1290, DOI 10.1038/ajg.2011.86
   Ding JH, 2020, WORLD J GASTROENTERO, V26, P6141, DOI 10.3748/wjg.v26.i40.6141
   Drossman DA, 2016, GASTROENTEROLOGY, V150, P1262, DOI 10.1053/j.gastro.2016.02.032
   El-Salhy M, 2015, NUTR J, V14, DOI 10.1186/s12937-015-0022-3
   El-Serag Hashem B, 2003, Rev Gastroenterol Disord, V3 Suppl 2, pS3
   Eslam M, 2020, J HEPATOL, V73, P202, DOI 10.1016/j.jhep.2020.03.039
   Fond G, 2014, EUR ARCH PSY CLIN N, V264, P651, DOI 10.1007/s00406-014-0502-z
   Ford AC, 2009, CLIN GASTROENTEROL H, V7, P1279, DOI 10.1016/j.cgh.2009.06.031
   Fouad YM, 2010, J GASTROEN HEPATOL, V25, P1285, DOI 10.1111/j.1440-1746.2010.06311.x
   Francque S, 2018, ACTA GASTRO-ENT BELG, V81, P55
   Fritz E, 2009, EUR J GASTROEN HEPAT, V21, P370, DOI 10.1097/MEG.0b013e328318ed19
   Halmos EP, 2014, GASTROENTEROLOGY, V146, P67, DOI 10.1053/j.gastro.2013.09.046
   Hermans MP, 2013, DIABETES METAB, V39, P322, DOI 10.1016/j.diabet.2013.05.005
   Higarza SG, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0223019
   Ilan Y, 2012, WORLD J GASTROENTERO, V18, P2609, DOI 10.3748/wjg.v18.i21.2609
   Jeffery IB, 2012, GUT, V61, P997, DOI 10.1136/gutjnl-2011-301501
   Jennings J, 2018, CURR VASC PHARMACOL, V16, P209, DOI 10.2174/1570161115666170622074007
   Johannesson E, 2011, AM J GASTROENTEROL, V106, P915, DOI 10.1038/ajg.2010.480
   Ko GTC, 1999, DIABETIC MED, V16, P670, DOI 10.1046/j.1464-5491.1999.00135.x
   Kwak MS, 2018, KOREAN J INTERN MED, V33, P64, DOI 10.3904/kjim.2017.343
   Kwong EK, 2021, TRANSL GASTROENT HEP, V6, DOI 10.21037/tgh.2020.02.18
   Lanthier N, 2020, ACTA GASTRO-ENT BELG, V83, P513
   Lee CG, 2015, AM J GASTROENTEROL, V110, P310, DOI 10.1038/ajg.2014.422
   Lee SH, 2016, YONSEI MED J, V57, P146, DOI 10.3349/ymj.2016.57.1.146
   Lee Yeong Yeh, 2017, Curr Gastroenterol Rep, V19, P56, DOI 10.1007/s11894-017-0595-4
   Majumdar A, 2020, METABOLISM, V111, DOI 10.1016/j.metabol.2020.154291
   Malaguarnera M, 2012, DIGEST DIS SCI, V57, P545, DOI 10.1007/s10620-011-1887-4
   Malinen E, 2005, AM J GASTROENTEROL, V100, P373, DOI 10.1111/j.1572-0241.2005.40312.x
   Matto J, 2005, FEMS IMMUNOL MED MIC, V43, P213, DOI 10.1016/j.femsim.2004.08.009
   Meroni M, 2019, NUTRIENTS, V11, DOI 10.3390/nu11112642
   Mizuno S, 2017, DIGESTION, V96, P29, DOI 10.1159/000471919
   Moser G, 2018, WIEN MED WOCHENSCHR, V168, P62, DOI 10.1007/s10354-017-0592-0
   Nobili V, 2018, ARCH MED SCI, V14, P81, DOI 10.5114/aoms.2016.62150
   Ohlsson B, 2016, SCAND J GASTROENTERO, V51, P1299, DOI 10.1080/00365521.2016.1209786
   Oka P, 2020, LANCET GASTROENTEROL, V5, P908, DOI 10.1016/S2468-1253(20)30217-X
   Ouyang X, 2008, J HEPATOL, V48, P993, DOI 10.1016/j.jhep.2008.02.011
   Poortmans P, 2020, ACTA GASTRO-ENT BELG, V83, P461
   Quan C, 2008, AM J GASTROENTEROL, V103, P2023, DOI 10.1111/j.1572-0241.2008.01943.x
   Satapathy SK, 2021, CLIN TRANSL GASTROEN, V12, DOI 10.14309/ctg.0000000000000302
   Scully P, 2010, AM J GASTROENTEROL, V105, P2235, DOI 10.1038/ajg.2010.159
   Sibelli A, 2016, PSYCHOL MED, V46, P3065, DOI 10.1017/S0033291716001987
   Singh S, 2015, CLIN GASTROENTEROL H, V13, P643, DOI 10.1016/j.cgh.2014.04.014
   Sterling RK, 2006, HEPATOLOGY, V43, P1317, DOI 10.1002/hep.21178
   Talley NJ, 1999, BEST PRACT RES CL GA, V13, P371, DOI 10.1053/bega.1999.0033
   Vernon G, 2011, ALIMENT PHARM THER, V34, P274, DOI 10.1111/j.1365-2036.2011.04724.x
   Zhang SL, 2021, DIABETES RES CLIN PR, V172, DOI 10.1016/j.diabres.2020.108645
NR 57
TC 1
Z9 1
U1 1
U2 1
PU UNIV CATHOLIQUE LOUVAIN-UCL
PI BRUSSELS
PA CLIN UNIV SAINT LUC, AVE HIPPOCRATE 10, BRUSSELS, B-1200, BELGIUM
SN 1784-3227
J9 ACTA GASTRO-ENT BELG
JI Acta Gastro-Enterol. Belg.
PD OCT-DEC
PY 2021
VL 84
IS 4
BP 541
EP 547
DI 10.51821/84.4.003
PG 7
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA YD9VY
UT WOS:000740782400001
PM 34965034
OA Bronze
DA 2023-06-08
ER

PT J
AU Tung, YT
   Zeng, JL
   Ho, ST
   Xu, JW
   Lin, IH
   Wu, JH
AF Tung, Yu-Tang
   Zeng, Jun-Lan
   Ho, Shang-Tse
   Xu, Jin-Wei
   Lin, I-Hsuan
   Wu, Jyh-Horng
TI Djulis Hull Improves Insulin Resistance and Modulates the Gut Microbiota
   in High-Fat Diet (HFD)-Induced Hyperglycaemia
SO ANTIOXIDANTS
LA English
DT Article
DE djulis; hull; type 2 diabetes; antioxidant enzyme; gut microbiota; tight
   junction protein
ID INDUCED OBESITY; SKELETAL-MUSCLE; LIVER; MICE; DISEASE; INFLAMMATION;
   MACROPHAGES; METFORMIN; PATHWAY; WEIGHT
AB In this study, we annotated the major flavonoid glycoside, rutin, of djulis hull crude extract using a Global Natural Products Social Molecular Networking (GNPS) library and its MS/MS spectra. To evaluate the protective effect of djulis hull crude extract and rutin on glucose tolerance, we fed mice a high-fat diet (HFD) for 16 weeks to induce hyperglycaemia. These results showed that crude extract significantly decreased HFD-induced elevation in the area under the curve (AUC) of weekly random blood glucose and oral glucose tolerance tests (OGTT), homeostasis model assessment (HOMA-IR), and advanced glycation end product (AGE) levels, and significantly increased pIRS1 and Glut4 protein expression in epididymal white adipose tissue (eWAT) and liver. Furthermore, the HFD-induced reduction in the activity of glutathione peroxidase (GPx) and catalase (CAT) was reversed by crude extract. In addition, ZO-1 and occludin protein expression in the colon was markedly downregulated in HFD-fed mice, resulting in decreased intestinal permeability and lipopolysaccharide (LPS) translocation, but were restored following crude extract. Moreover, the crude extract intervention had a profound effect on the alpha diversity and microbial community in the gut microbiota. Therefore, djulis hull crude extract could improve blood glucose and increase insulin receptor sensitivity in HFD-induced hyperglycaemia, which is likely due to its modulation of the gut microbiota, preservation of the integrity of the intestinal barrier to reduce body inflammation, increased antioxidant activity, and modulation of insulin signalling.
C1 [Tung, Yu-Tang] Natl Chung Hsing Univ, Grad Inst Biotechnol, Taichung 402, Taiwan.
   [Tung, Yu-Tang] Taipei Med Univ Hosp, Nutr Res Ctr, Taipei 110, Taiwan.
   [Tung, Yu-Tang] Taipei Med Univ, Wan Fang Hosp, Cell Physiol & Mol Image Res Ctr, Taipei 116, Taiwan.
   [Zeng, Jun-Lan; Xu, Jin-Wei; Wu, Jyh-Horng] Natl Chung Hsing Univ, Dept Forestry, Taichung 402, Taiwan.
   [Ho, Shang-Tse] Natl Chiayi Univ, Dept Wood Based Mat & Design, Chiayi 600, Taiwan.
   [Lin, I-Hsuan] Univ Manchester, Bioinformat Core Facil, Manchester M13 9PT, Lancs, England.
   [Lin, I-Hsuan] Taipei Med Univ, TMU Res Ctr Canc Translat Med, Taipei 110, Taiwan.
C3 National Chung Hsing University; Taipei Medical University; Taipei
   Medical University Hospital; Taipei Medical University; Taipei Municipal
   WanFang Hospital; National Chung Hsing University; National Chiayi
   University; N8 Research Partnership; University of Manchester; Taipei
   Medical University
RP Wu, JH (通讯作者)，Natl Chung Hsing Univ, Dept Forestry, Taichung 402, Taiwan.
EM peggytung@nchu.edu.tw; arashi0221@smail.nchu.edu.tw;
   stho@mail.ncyu.edu.tw; ecsgunro@gmail.com; i-hsuan.lin@manchester.ac.uk;
   eric@nchu.edu.tw
RI Lin, I-Hsuan/N-6501-2013
OI Lin, I-Hsuan/0000-0002-6207-1299; Wu, Jyh-Horng/0000-0002-1187-1114; Xu,
   JinWei/0000-0002-5935-3463
FU Ministry of Science and Technology, Taiwan [MOST 110-2320-B-005-009]
FX This work was financially supported by a research grant from the
   Ministry of Science and Technology, Taiwan (MOST 110-2320-B-005-009).
CR AL-Ishaq RK, 2019, BIOMOLECULES, V9, DOI 10.3390/biom9090430
   Amer Diabet Assoc, 2014, DIABETES CARE, V37, pS81, DOI [10.2337/dc13-S067, 10.2337/dc14-S081, 10.2337/dc13-S011, 10.2337/dc10-S062, 10.2337/dc10-S011, 10.2337/dc11-S062, 10.2337/dc12-s064, 10.2337/dc11-S011]
   Asnicar F, 2015, PEERJ, V3, DOI 10.7717/peerj.1029
   Avogaro A, 2008, FREE RADICAL BIO MED, V44, P1209, DOI 10.1016/j.freeradbiomed.2007.12.021
   Bai YF, 2019, NUTR DIABETES, V9, DOI 10.1038/s41387-019-0097-6
   Moreira APB, 2012, BRIT J NUTR, V108, P801, DOI 10.1017/S0007114512001213
   Callahan BJ, 2016, NAT METHODS, V13, P581, DOI [10.1038/NMETH.3869, 10.1038/nmeth.3869]
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Cepas V, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9020142
   Chang CJ, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms8489
   Chen J, 2012, BIOINFORMATICS, V28, P2106, DOI 10.1093/bioinformatics/bts342
   Chen S., 2019, J FOOD NUTR RES, V7, P452, DOI [10.12691/jfnr-7-6-7, DOI 10.12691/JFNR-7-6-7]
   Chen SY, 2019, FOOD BIOSCI, V32, DOI 10.1016/j.fbio.2019.100469
   Chu CC, 2016, J FUNCT FOODS, V26, P585, DOI 10.1016/j.jff.2016.08.025
   Chyau CC, 2018, MOLECULES, V23, DOI 10.3390/molecules23071780
   Clarke SF, 2012, GUT MICROBES, V3, P186, DOI 10.4161/gmic.20168
   Commerford SR, 2001, AM J PHYSIOL-REG I, V281, pR1380, DOI 10.1152/ajpregu.2001.281.5.R1380
   Delzenne NM, 2011, NAT REV ENDOCRINOL, V7, P639, DOI 10.1038/nrendo.2011.126
   Ding SL, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0012191
   Esquivel-Elizondo S, 2017, MSYSTEMS, V2, DOI 10.1128/mSystems.00051-17
   Everard A, 2014, ISME J, V8, P2116, DOI 10.1038/ismej.2014.45
   Fuke N, 2019, NUTRIENTS, V11, DOI 10.3390/nu11102277
   Fuller S, 2014, EVID-BASED COMPL ALT, V2014, DOI 10.1155/2014/862575
   Ganesh BP, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0074963
   Gao J, 2019, FOOD RES INT, V121, P278, DOI 10.1016/j.foodres.2019.03.029
   Gerard C, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00029
   Guo Shaodong, 2013, Drug Discov Today Dis Mech, V10, pe27
   Harsha PSCS, 2016, J SCI FOOD AGR, V96, P656, DOI 10.1002/jsfa.7137
   He NN, 2020, FOOD FUNCT, V11, P9947, DOI [10.1039/d0fo01871f, 10.1039/D0FO01871F]
   Ho NT, 2019, CANCERS, V11, DOI 10.3390/cancers11091384
   Hoffler U, 2009, ENDOCRINE, V36, P311, DOI 10.1007/s12020-009-9224-9
   Hong YH, 2016, BIOMED RES INT, V2016, DOI 10.1155/2016/7368797
   Ikeda S, 2013, BIOCHEM BIOPH RES CO, V441, P36, DOI 10.1016/j.bbrc.2013.10.005
   Kahn BB, 2000, J CLIN INVEST, V106, P473, DOI 10.1172/JCI10842
   Kang YB, 2019, INT J OBESITY, V43, P1631, DOI 10.1038/s41366-018-0187-x
   Karkman A, 2017, ANN NY ACAD SCI, V1399, P78, DOI 10.1111/nyas.13326
   Karpe F, 2011, DIABETES, V60, P2441, DOI 10.2337/db11-0425
   Kim KA, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0047713
   Kirpich IA, 2015, CLIN BIOCHEM, V48, P923, DOI 10.1016/j.clinbiochem.2015.06.023
   Kizelsztein P, 2009, AM J PHYSIOL-ENDOC M, V296, pE433, DOI 10.1152/ajpendo.90772.2008
   Koliada A, 2017, BMC MICROBIOL, V17, DOI 10.1186/s12866-017-1027-1
   Kong C, 2019, NUTRITION, V60, P175, DOI 10.1016/j.nut.2018.10.002
   Lecomte V, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0126931
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Leguisamo NM, 2012, CARDIOVASC DIABETOL, V11, DOI 10.1186/1475-2840-11-100
   Li HB, 2015, BRAZ J MED BIOL RES, V48, P440, DOI [10.1590/1414-431X20144238, 10.1590/1414-431x20144238]
   Li S, 2018, FOOD FUNCT, V9, P5371, DOI 10.1039/c8fo01174e
   Liang YJ, 2019, PROBIOTICS ANTIMICRO, V11, P175, DOI 10.1007/s12602-017-9378-3
   Liu J, 2018, PHARMACOL RES, V134, P40, DOI 10.1016/j.phrs.2018.05.012
   Ma LY, 2020, GUT MICROBES, V12, DOI 10.1080/19490976.2020.1832857
   Maleckas A, 2015, SCAND J SURG, V104, P40, DOI 10.1177/1457496914561140
   Mardinoglu A, 2016, CELL METAB, V23, P10, DOI 10.1016/j.cmet.2015.12.012
   Markowiak P, 2017, NUTRIENTS, V9, DOI 10.3390/nu9091021
   Martin M., 2011, EMBNET J, V17, P10, DOI DOI 10.14806/EJ.17.1.200
   McMurdie PJ, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0061217
   Mena P, 2020, INT J FOOD SCI NUTR, V71, P783, DOI 10.1080/09637486.2020.1826913
   Mendez-Garcia LA, 2018, SCAND J IMMUNOL, V88, DOI 10.1111/sji.12716
   Monteagudo-Mera A, 2016, BENEF MICROBES, V7, P247, DOI 10.3920/BM2015.0114
   Muthenna P, 2012, BRIT J NUTR, V107, P941, DOI 10.1017/S0007114511004077
   Ohland CL, 2013, PSYCHONEUROENDOCRINO, V38, P1738, DOI 10.1016/j.psyneuen.2013.02.008
   Parekh PI, 1998, METABOLISM, V47, P1089, DOI 10.1016/S0026-0495(98)90283-9
   Pashikanti S, 2010, FREE RADICAL BIO MED, V48, P656, DOI 10.1016/j.freeradbiomed.2009.11.019
   Quast C, 2013, NUCLEIC ACIDS RES, V41, pD590, DOI 10.1093/nar/gks1219
   Reaven GM, 2005, CELL METAB, V1, P9, DOI 10.1016/j.cmet.2004.12.001
   Safari Z, 2019, NUTR RES, V71, P72, DOI 10.1016/j.nutres.2019.09.004
   Saltiel AR, 2001, NATURE, V414, P799, DOI 10.1038/414799a
   Sanz Y, 2015, PEDIATR RES, V77, P236, DOI 10.1038/pr.2014.170
   Sartini A, 2018, CELL DEATH DIS, V9, DOI 10.1038/s41419-017-0124-2
   Segata N, 2011, GENOME BIOL, V12, DOI 10.1186/gb-2011-12-6-r60
   Shang Q., 2020, BIOACT CARBOHYDR DIE, V23, DOI [10.1016/j.bcdf.2020.100221, DOI 10.1016/J.BCDF.2020.100221]
   Sharma S, 2019, J NUTR BIOCHEM, V63, P101, DOI 10.1016/j.jnutbio.2018.10.003
   Shaul ME, 2010, DIABETES, V59, P1171, DOI 10.2337/db09-1402
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Smith BJ, 2021, MSPHERE, V6, DOI 10.1128/msphere.00851-21
   Song M, 2015, J DAIRY SCI, V98, P1492, DOI 10.3168/jds.2014-8586
   Sun XW, 2020, J AGR FOOD CHEM, V68, P5118, DOI 10.1021/acs.jafc.0c01467
   Talsness CE, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0188011
   Teixeira LG, 2011, LIPIDS HEALTH DIS, V10, DOI 10.1186/1476-511X-10-204
   Thaiss CA, 2018, SCIENCE, V359, P1376, DOI 10.1126/science.aar3318
   Troseid M, 2013, DIABETES CARE, V36, P3627, DOI 10.2337/dc13-0451
   Tu DG, 2020, FOODS, V9, DOI 10.3390/foods9101514
   Tung YT, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10111694
   Vancamelbeke M, 2017, EXPERT REV GASTROENT, V11, P821, DOI 10.1080/17474124.2017.1343143
   Velazquez KT, 2019, WORLD J HEPATOL, V11, P619, DOI 10.4254/wjh.v11.i8.619
   Verdam FJ, 2013, OBESITY, V21, pE607, DOI 10.1002/oby.20466
   Wang HY, 2014, FOOD CHEM TOXICOL, V69, P347, DOI 10.1016/j.fct.2014.04.008
   Wang R, 2019, BIOMED PHARMACOTHER, V115, DOI 10.1016/j.biopha.2019.108945
   Wang YF, 2008, OBESITY, V16, P2323, DOI 10.1038/oby.2008.351
   Wen YP, 2017, SCI BULL, V62, P405, DOI 10.1016/j.scib.2017.01.027
   Wilson ID, 2009, CURR PHARM DESIGN, V15, P1519, DOI 10.2174/138161209788168173
   Wright ES, 2015, BMC BIOINFORMATICS, V16, DOI 10.1186/s12859-015-0749-z
   Wu HJ, 2012, GUT MICROBES, V3, P4, DOI 10.4161/gmic.19320
   Yang Q, 2020, NUTRIENTS, V12, DOI 10.3390/nu12020381
   Yang SC, 2019, NUTRIENTS, V11, DOI 10.3390/nu11092033
   Yu SH, 2015, J DIABETES RES, V2015, DOI 10.1155/2015/723190
   Zhang XL, 2008, PANCREAS, V37, pE31, DOI 10.1097/MPA.0b013e3181744b50
   Zhou D, 2012, OBESITY, V20, P1577, DOI 10.1038/oby.2012.42
NR 97
TC 4
Z9 4
U1 2
U2 16
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD JAN
PY 2022
VL 11
IS 1
AR 45
DI 10.3390/antiox11010045
PG 22
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA YO0KS
UT WOS:000747638000001
PM 35052549
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Pearson, ER
AF Pearson, E. R.
TI Personalized medicine in diabetes: the role of 'omics' and biomarkers
SO DIABETIC MEDICINE
LA English
DT Review
ID METFORMIN TREATMENT RESPONSE; CATION TRANSPORTER 1;
   ATAXIA-TELANGIECTASIA; GUT FLORA; TYPE-2; INSULIN; GENE; ATM;
   SULFONYLUREAS; HYPERGLYCEMIA
AB Personalized medicine, otherwise called stratified or precision medicine, aims to better target intervention to the individual to maximize benefit and minimize harm. This review discusses how diabetes aetiology, pathophysiology and patient genotype influence response to or side effects of the commonly used diabetes treatments. C-peptide is a useful biomarker that is underused to guide treatment choice, severe insulin deficiency predicts non-response to glucagon-like peptide-1 receptor agonists, and thiazolidinediones are more effective in insulin-resistant patients. The field of pharmacogenetics is now yielding clinically important results, with three examples outlined: sulphonylurea sensitivity in patients with HNF1A maturity-onset diabetes of the young; sulphonylurea sensitivity in patients with Type 2 diabetes with reduced function alleles at CYP2C9, resulting in reduced metabolism of sulphonylureas; and severe metformin intolerance associated with reduced function organic cation transporter 1 (OCT1) variants, exacerbated by drugs that also inhibit OCT1. Genome-wide approaches and the potential of other 'omics', including metagenomics and metabolomics, are then outlined, highlighting the complex interacting networks that we need to understand before we can truly personalize diabetes treatments.
C1 [Pearson, E. R.] Univ Dundee, Med Res Inst, Div Cardiovasc & Diabet Med, Dundee, Scotland.
C3 University of Dundee
RP Pearson, ER (通讯作者)，Univ Dundee, Med Res Inst, Div Cardiovasc & Diabet Med, Dundee, Scotland.
EM E.Z.Pearson@dundee.ac.uk
OI Pearson, Ewan/0000-0001-9237-8585
FU Wellcome Trust [102820/Z/13/Z]
FX E.P. holds a Wellcome Trust New Investigator award (102820/Z/13/Z). Many
   thanks to Ms Caroline Glen who extracted the data required for Fig. 1,
   and to Dr Jose Florez who provided the graph, derived from published
   data, shown in Fig. 2.
CR Arar NH, 2008, INVEST OPHTH VIS SCI, V49, P3839, DOI 10.1167/iovs.07-1633
   Burton Jeffrey H, 2015, J Diabetes Sci Technol, V9, P808, DOI 10.1177/1932296815577425
   Connelly PJ, 2016, DIABETIC MED, V33, P371, DOI 10.1111/dme.13037
   DOBKIN JF, 1983, SCIENCE, V220, P325
   Dujic T, 2016, DIABETIC MED, V33, P511, DOI 10.1111/dme.13040
   Dujic T, 2015, DIABETES, V64, P1786, DOI 10.2337/db14-1388
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   GODARTS, 2011, NAT GENET, V43, P117, DOI DOI 10.1038/NG.735
   Holstein A, 2011, EUR J CLIN PHARMACOL, V67, P471, DOI 10.1007/s00228-010-0976-1
   Inzucchi SE, 2015, DIABETES CARE, V38, P140, DOI 10.2337/dc14-2441
   Jones AG, 2016, DIABETES CARE, V39, P250, DOI 10.2337/dc15-0258
   Jones TA, 2003, DIABETES OBES METAB, V5, P163, DOI 10.1046/j.1463-1326.2003.00258.x
   Kaddurah-Daouk R, 2015, CLIN PHARMACOL THER, V98, P71, DOI 10.1002/cpt.134
   Kaddurah-Daouk R, 2011, TRANSL PSYCHIAT, V1, DOI 10.1038/tp.2011.22
   Li H, 2013, CLIN PHARMACOL THER, V94, P574, DOI 10.1038/clpt.2013.157
   LINDENBAUM J, 1981, NEW ENGL J MED, V305, P789, DOI 10.1056/NEJM198110013051403
   Mavrou A, 2008, ANTICANCER RES, V28, P401
   McCreight LJ, 2016, DIABETOLOGIA, V59, P426, DOI 10.1007/s00125-015-3844-9
   Pearson ER, 2003, LANCET, V362, P1275, DOI 10.1016/S0140-6736(03)14571-0
   Ragia G, 2009, PHARMACOGENOMICS, V10, P1781, DOI 10.2217/PGS.09.96
   SCHALCH DS, 1970, NEW ENGL J MED, V282, P1396, DOI 10.1056/NEJM197006182822503
   Shepherd M, 2003, DIABETES CARE, V26, P3191, DOI 10.2337/diacare.26.11.3191-a
   Shields BM, 2010, DIABETOLOGIA, V53, P2504, DOI 10.1007/s00125-010-1799-4
   Shu Y, 2007, J CLIN INVEST, V117, P1422, DOI 10.1172/JCI30558
   van Leeuwen N, 2012, DIABETOLOGIA, V55, P1971, DOI 10.1007/s00125-012-2537-x
   Zhou K, 2010, CLIN PHARMACOL THER, V87, P52, DOI 10.1038/clpt.2009.176
   Zhou KX, 2014, LANCET DIABETES ENDO, V2, P481, DOI 10.1016/S2213-8587(14)70050-6
   Zhou Y, 2014, INT J CLIN PRACT, V68, P1462, DOI 10.1111/ijcp.12534
NR 28
TC 45
Z9 47
U1 1
U2 26
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0742-3071
EI 1464-5491
J9 DIABETIC MED
JI Diabetic Med.
PD JUN
PY 2016
VL 33
IS 6
BP 712
EP 717
DI 10.1111/dme.13075
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DR5FZ
UT WOS:000379930200002
PM 26802434
OA Green Published, hybrid
DA 2023-06-08
ER

PT J
AU Stathopoulou, C
   Nikoleri, D
   Bertsias, G
AF Stathopoulou, Chrysoula
   Nikoleri, Dimitra
   Bertsias, George
TI Immunometabolism: an overview and therapeutic prospects in autoimmune
   diseases
SO IMMUNOTHERAPY
LA English
DT Review
DE adaptive immunity; autoimmune disease; biomarkers; glycolysis; innate
   immunity; metabolites; microbiota; oxidative phosphorylation
ID REMITTING MULTIPLE-SCLEROSIS; T-CELL METABOLISM; HMG-COA REDUCTASE;
   RHEUMATOID-ARTHRITIS; GUT MICROBIOTA; DENDRITIC CELL; DIMETHYL FUMARATE;
   HUMAN-NEUTROPHILS; KREBS CYCLE; MOUSE MODEL
AB Metabolism is a critical immune regulator under physiologic and pathologic conditions. Culminating evidence has disentangled the contribution of distinct metabolic pathways, namely glucolysis, pentose phosphate, fatty acid oxidation, glutaminolysis, Krebs cycle and oxidative phosphorylation, in modulating innate and adaptive immune cells based on their activation/differentiation state. Metabolic aberrations and changes in the intracellular levels of specific metabolites are linked to the inflammatory phenotype of immune cells implicated in autoimmune disorders such as systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis and diabetes. Notably, targeting metabolism such as the mTOR by rapamycin, hexokinase by 2-deoxy-D-glucose, AMP-activated protein kinase by metformin, may be used to ameliorate autoimmune inflammation. Accordingly, research in immunometabolism is expected to offer novel opportunities for monitoring and treating immune-mediated diseases.
C1 [Stathopoulou, Chrysoula; Nikoleri, Dimitra; Bertsias, George] Univ Crete, Fac Med, Univ Hosp Heraklion, Dept Rheumatol Clin Immunol & Allergy, Iraklion 71003, Greece.
   [Stathopoulou, Chrysoula; Nikoleri, Dimitra; Bertsias, George] Univ Crete, Lab Rheumatol Autoimmun & Inflammat, Fac Med, Iraklion 71003, Greece.
   [Stathopoulou, Chrysoula; Nikoleri, Dimitra; Bertsias, George] Fdn Res & Technol, Inst Mol Biol & Biotechnol, N Plastira 100, Iraklion 70013, Greece.
C3 University Hospital of Heraklion; University of Crete; University of
   Crete
RP Bertsias, G (通讯作者)，Univ Crete, Fac Med, Univ Hosp Heraklion, Dept Rheumatol Clin Immunol & Allergy, Iraklion 71003, Greece.; Bertsias, G (通讯作者)，Univ Crete, Lab Rheumatol Autoimmun & Inflammat, Fac Med, Iraklion 71003, Greece.; Bertsias, G (通讯作者)，Fdn Res & Technol, Inst Mol Biol & Biotechnol, N Plastira 100, Iraklion 70013, Greece.
EM gbertsias@uoc.gr
RI Bertsias, George/AAA-8400-2020
OI Bertsias, George/0000-0001-5299-1406
CR Ai Teresa L, 2014, IMMUNOL REV, V259, P60
   Akesson K, 2018, LUPUS SCI MED, V5, DOI 10.1136/lupus-2017-000254
   Arts RJW, 2016, CELL METAB, V24, P807, DOI 10.1016/j.cmet.2016.10.008
   Bantug GR, 2018, NAT REV IMMUNOL, V18, P19, DOI 10.1038/nri.2017.99
   Beezhold K, 2018, CANCER LETT, V414, P127, DOI 10.1016/j.canlet.2017.11.005
   Bengtsson AA, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0159384
   Bluestone JA, 2015, SCI TRANSL MED, V7, DOI 10.1126/scitranslmed.aad4134
   Bomprezzi R, 2015, THER ADV NEUROL DISO, V8, P20, DOI 10.1177/1756285614564152
   BORREGAARD N, 1982, J CLIN INVEST, V70, P550, DOI 10.1172/JCI110647
   Bruyn GAW, 2008, ANN RHEUM DIS, V67, P1090, DOI 10.1136/ard.2007.078808
   Burg JS, 2011, PROG LIPID RES, V50, P403, DOI 10.1016/j.plipres.2011.07.002
   Bustamante MF, 2018, ANN RHEUM DIS, V77, P1636, DOI 10.1136/annrheumdis-2018-213103
   BUTS JP, 1993, DIGEST DIS SCI, V38, P1091, DOI 10.1007/BF01295726
   Campisi L, 2016, NAT IMMUNOL, V17, P1084, DOI 10.1038/ni.3512
   Cantor J, 2009, NAT IMMUNOL, V10, P412, DOI 10.1038/ni.1712
   Chang PV, 2014, P NATL ACAD SCI USA, V111, P2247, DOI 10.1073/pnas.1322269111
   Chapman NM, 2014, IMMUNOTHERAPY-UK, V6, P1295, DOI 10.2217/imt.14.84
   Cheng SC, 2014, SCIENCE, V345, P1579, DOI 10.1126/science.1250684
   Cusick MF, 2012, CLIN REV ALLERG IMMU, V42, P102, DOI [10.1007/s12016-011-8294-7, 10.1007/s12016-011-8293-8]
   Dhir A, 2018, NATURE, V560, P238, DOI 10.1038/s41586-018-0363-0
   Drusian L, 2018, CELL REP, V24, P1093, DOI 10.1016/j.celrep.2018.06.106
   Dutta T, 2012, DIABETES, V61, P1004, DOI 10.2337/db11-0874
   Espinoza-Jimenez A, 2012, MEDIAT INFLAMM, V2012, DOI 10.1155/2012/815953
   Falconer J, 2018, ARTHRITIS RHEUMATOL, V70, P984, DOI 10.1002/art.40504
   Fernandez D, 2006, ARTHRITIS RHEUM-US, V54, P2983, DOI 10.1002/art.22085
   Fiandaca MS, 2015, FRONT NEUROL, V6, DOI 10.3389/fneur.2015.00237
   Fossati G, 2003, J IMMUNOL, V170, P1964, DOI 10.4049/jimmunol.170.4.1964
   Franchina DG, 2018, TRENDS IMMUNOL, V39, P489, DOI 10.1016/j.it.2018.01.005
   Freitag J, 2016, IMMUNOL CELL BIOL, V94, P925, DOI 10.1038/icb.2016.77
   Furusawa Y, 2013, NATURE, V504, P446, DOI 10.1038/nature12721
   Geltink RIK, 2018, ANNU REV IMMUNOL, V36, P461, DOI 10.1146/annurev-immunol-042617-053019
   Generali E, 2017, J AUTOIMMUN, V83, P51, DOI 10.1016/j.jaut.2017.04.005
   Gerriets VA, 2015, J CLIN INVEST, V125, P194, DOI 10.1172/JCI76012
   Gianfrancesco M.A., 2016, J NEUROL NEUROMED, V1, P1
   Gkirtzimanaki K, 2018, CELL REP, V25, P921, DOI 10.1016/j.celrep.2018.09.001
   Golden JB, 2013, CYTOKINE, V62, P195, DOI 10.1016/j.cyto.2013.03.013
   Graham DB, 2018, CELL REP, V24, P838, DOI 10.1016/j.celrep.2018.06.081
   Heiden MGV, 2009, SCIENCE, V324, P1029, DOI 10.1126/science.1160809
   Hemmer B, 2015, LANCET NEUROL, V14, P406, DOI 10.1016/S1474-4422(14)70305-9
   Herold KC, 2013, NAT REV IMMUNOL, V13, P243, DOI 10.1038/nri3422
   Hiebert P, 2018, NAT MED, V24, P537, DOI 10.1038/s41591-018-0027-5
   Hoque R, 2014, GASTROENTEROLOGY, V146, P1763, DOI 10.1053/j.gastro.2014.03.014
   Huang N, 2018, TRENDS IMMUNOL, V39, P562, DOI 10.1016/j.it.2018.04.006
   Hultqvist M, 2009, TRENDS IMMUNOL, V30, P201, DOI 10.1016/j.it.2009.03.004
   Infantino V, 2013, BIOCHEM BIOPH RES CO, V440, P105, DOI 10.1016/j.bbrc.2013.09.037
   Jansson J, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0006386
   Jellusova J, 2017, NAT IMMUNOL, V18, P303, DOI 10.1038/ni.3664
   Jellusova J, 2016, CRIT REV BIOCHEM MOL, V51, P359, DOI 10.1080/10409238.2016.1215288
   Julia A, 2018, ARTHRITIS RES THER, V20, DOI 10.1186/s13075-018-1604-1
   Karonitsch T, 2018, CELL REP, V23, P2157, DOI 10.1016/j.celrep.2018.04.044
   Kibe R, 2014, SCI REP-UK, V4, DOI 10.1038/srep04548
   Kim J, 2016, AMINO ACIDS, V48, P915, DOI 10.1007/s00726-016-2171-x
   Kim S, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0097501
   Kornberg MD, 2018, NATURE, V453, P449, DOI DOI 10.1126/SCIENCE.AAN4665
   Kotake S, 2017, J CLIN MED, V6, DOI 10.3390/jcm6070067
   Kuhtreiber WM, 2018, NPJ VACCINES, V3, DOI 10.1038/s41541-018-0062-8
   Kunisawa J, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0032094
   La Rocca C, 2017, METABOLISM, V77, P39, DOI 10.1016/j.metabol.2017.08.011
   Lanzillo R, 2017, CLIN IMMUNOL, V183, P249, DOI 10.1016/j.clim.2017.08.011
   Laurberg P, 2006, EUR J ENDOCRINOL, V155, P219, DOI 10.1530/eje.1.02210
   Levy M, 2017, CURR OPIN MICROBIOL, V35, P8, DOI 10.1016/j.mib.2016.10.003
   Li F, 2015, CELL PHYSIOL BIOCHEM, V37, P1279, DOI 10.1159/000430251
   Li P, 2017, FRONT PHARMACOL, V8, DOI 10.3389/fphar.2017.00460
   Li XJ, 2018, NAT REV MOL CELL BIO, V19, P563, DOI 10.1038/s41580-018-0029-7
   Li XB, 2015, THORAC CANCER, V6, P17, DOI 10.1111/1759-7714.12148
   Limon JJ, 2012, FRONT IMMUNOL, V3, DOI 10.3389/fimmu.2012.00228
   Littlewood-Evans A, 2016, J EXP MED, V213, P1655, DOI 10.1084/jem.20160061
   Llorente C, 2015, CELL MOL GASTROENTER, V1, P275, DOI 10.1016/j.jcmgh.2015.04.003
   MADZIMBAMUTO FD, 2013, J CLIN CELL IMMUNO S, V13, DOI DOI 10.1186/1472-698X-13-27
   Malaguti C, 2014, FREE RADICAL RES, V48, P1494, DOI 10.3109/10715762.2014.966706
   Manzel A, 2014, CURR ALLERGY ASTHM R, V14, DOI 10.1007/s11882-013-0404-6
   Marino E, 2017, NAT IMMUNOL, V18, P552, DOI 10.1038/ni.3713
   Matsushita M, 2018, SCIENCE, V360, P377, DOI 10.1126/science.aat4984
   McGettrick AF, 2013, J BIOL CHEM, V288, P22893, DOI 10.1074/jbc.R113.486464
   Mills EL, 2018, NATURE, V556, P113, DOI 10.1038/nature25986
   Mohammad MG, 2013, INT J MOL SCI, V14, P547, DOI 10.3390/ijms14010547
   Morel L, 2017, NAT REV RHEUMATOL, V13, P280, DOI 10.1038/nrrheum.2017.43
   Moro-Sibilot L, 2016, GASTROENTEROLOGY, V151, P311, DOI 10.1053/j.gastro.2016.04.014
   Nakaya M, 2014, IMMUNITY, V40, P692, DOI 10.1016/j.immuni.2014.04.007
   Napoli I, 2010, EXP NEUROL, V225, P24, DOI 10.1016/j.expneurol.2009.04.024
   Nazaret C, 2009, J THEOR BIOL, V258, P455, DOI 10.1016/j.jtbi.2008.09.037
   Noga MJ, 2012, METABOLOMICS, V8, P253, DOI 10.1007/s11306-011-0306-3
   O'Neill LAJ, 2016, J EXP MED, V213, P15, DOI 10.1084/jem.20151570
   O'Neill LAJ, 2015, IMMUNITY, V42, P393, DOI 10.1016/j.immuni.2015.02.017
   Olmes G, 2016, ARTHRITIS RES THER, V18, DOI 10.1186/s13075-016-0989-y
   Oresic M, 2008, J EXP MED, V205, P2975, DOI 10.1084/jem.20081800
   Ottas A, 2017, ARCH DERMATOL RES, V309, P519, DOI 10.1007/s00403-017-1760-1
   Palacios BS, 2015, J PATHOL, V235, P515, DOI 10.1002/path.4466
   Papadaki HA, 2001, BRIT J HAEMATOL, V115, P167, DOI 10.1046/j.1365-2141.2001.03076.x
   Patra KC, 2014, TRENDS BIOCHEM SCI, V39, P347, DOI 10.1016/j.tibs.2014.06.005
   Pearce EJ, 2015, NAT REV IMMUNOL, V15, P18, DOI 10.1038/nri3771
   Perl A, 2004, TRENDS IMMUNOL, V25, P360, DOI 10.1016/j.it.2004.05.001
   Perl A, 2015, METABOLOMICS, V11, P1157, DOI 10.1007/s11306-015-0772-0
   Peruzzotti-Jametti L, 2018, TRENDS MOL MED, V24, P838, DOI 10.1016/j.molmed.2018.07.007
   Previte DM, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0175549
   Prud'homme GJ, 2014, BIOCHEM BIOPH RES CO, V452, P649, DOI 10.1016/j.bbrc.2014.08.135
   Quijano C, 2016, REDOX BIOL, V8, P28, DOI 10.1016/j.redox.2015.11.010
   Ramgolam VS, 2011, J IMMUNOL, V186, P4518, DOI 10.4049/jimmunol.1000271
   Reth M, 2002, NAT IMMUNOL, V3, P1129, DOI 10.1038/ni1202-1129
   Rooks MG, 2016, NAT REV IMMUNOL, V16, P341, DOI 10.1038/nri.2016.42
   Rose S, 2014, J TRANSL MED, V12, DOI 10.1186/s12967-014-0258-2
   Ryan DG, 2017, FEBS LETT, V591, P2992, DOI 10.1002/1873-3468.12744
   Saeed S, 2014, SCIENCE, V345, P1578, DOI 10.1126/science.1251086
   Shah M, 2013, J CONTROL RELEASE, V171, P269, DOI 10.1016/j.jconrel.2013.07.016
   Shirai T, 2016, J EXP MED, V213, P337, DOI 10.1084/jem.20150900
   Sinclair LV, 2013, NAT IMMUNOL, V14, P500, DOI 10.1038/ni.2556
   Singh N, 2010, J BIOL CHEM, V285, P27601, DOI 10.1074/jbc.M110.102947
   Singh S, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0181039
   Tannahill GM, 2013, NATURE, V496, P238, DOI 10.1038/nature11986
   Tannahill GM, 2015, FRONT IMMUNOL, V6, DOI 10.3389/fimmu.2015.00106
   Tian JD, 2004, J IMMUNOL, V173, P5298, DOI 10.4049/jimmunol.173.8.5298
   Venken K, 2010, TRENDS MOL MED, V16, P58, DOI 10.1016/j.molmed.2009.12.003
   Wang R., 2017, KELLEY FIRESTEINS TX, V10th ed., P318, DOI [10.1016/B978-0-323-31696-5.00020-6318-326, DOI 10.1016/B978-0-323-31696-5.00020-6318-326]
   Wang R, 2016, EUR J IMMUNOL, V46, P807, DOI 10.1002/eji.201545788
   Waters LR, 2018, ISCIENCE, V5, P99, DOI 10.1016/j.isci.2018.07.005
   Weichhart T, 2015, NAT REV IMMUNOL, V15, P599, DOI 10.1038/nri3901
   Wen ZK, 2019, NAT IMMUNOL, V20, P313, DOI 10.1038/s41590-018-0296-7
   Westerterp M, 2017, CELL METAB, V25, P1294, DOI 10.1016/j.cmet.2017.04.005
   Weyand CM, 2017, CURR OPIN IMMUNOL, V46, P112, DOI 10.1016/j.coi.2017.04.010
   Wheeler ML, 2012, J IMMUNOL, V189, P4405, DOI 10.4049/jimmunol.1201433
   Whitton JL, 2004, AUTOIMMUNITY, V37, P375, DOI 10.1080/08916930410001713089
   Widner B, 2000, IMMUNOBIOLOGY, V201, P621, DOI 10.1016/S0171-2985(00)80079-0
   Wu DJ, 2016, IMMUNITY, V44, P1325, DOI 10.1016/j.immuni.2016.06.006
   Wu H, 2017, SCI TRANSL MED, V8, P331
   Wu JX, 2013, SCIENCE, V339, P826, DOI 10.1126/science.1229963
   Yan D, 2017, PSORIASIS-TARGETS TH, V7, P1, DOI 10.2147/PTT.S118348
   Yang Z, 2016, SCI TRANSL MED, V8, DOI 10.1126/scitranslmed.aad7151
   Yin YM, 2015, SCI TRANSL MED, V7, DOI 10.1126/scitranslmed.aaa0835
   Yoshizaki A, 2010, ARTHRITIS RHEUM-US, V62, P2476, DOI 10.1002/art.27498
   Young SP, 2013, ARTHRITIS RHEUM-US, V65, P2015, DOI 10.1002/art.38021
   Youssef S, 2002, NATURE, V420, P78, DOI 10.1038/nature01158
   Zeisbrich M, 2018, ANN RHEUM DIS, V77, P1053, DOI 10.1136/annrheumdis-2017-212647
   Zhang HS, 2014, APPL ENVIRON MICROB, V80, P7551, DOI 10.1128/AEM.02676-14
   Zhang ZZ, 2018, NAT MED, V24, P617, DOI 10.1038/s41591-018-0003-0
   Zhao J, 2017, NAT GENET, V49, P433, DOI 10.1038/ng.3782
   Zhou CX, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0139635
   Zhou J, 2016, J PHARMACEUT BIOMED, V127, P60, DOI 10.1016/j.jpba.2016.02.004
NR 137
TC 35
Z9 36
U1 4
U2 19
PU FUTURE MEDICINE LTD
PI LONDON
PA UNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON, N3
   1QB, ENGLAND
SN 1750-743X
EI 1750-7448
J9 IMMUNOTHERAPY-UK
JI Immunotherapy
PD JUN
PY 2019
VL 11
IS 9
BP 813
EP 829
DI 10.2217/imt-2019-0002
PG 17
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA IA3XQ
UT WOS:000469496800007
PM 31120393
DA 2023-06-08
ER

PT J
AU Wang, MJ
   Doak, TG
   Ye, YZ
AF Wang, Mingjie
   Doak, Thomas G.
   Ye, Yuzhen
TI Subtractive assembly for comparative metagenomics, and its application
   to type 2 diabetes metagenomes
SO GENOME BIOLOGY
LA English
DT Article
DE Comparative metagenomics; Subtractive assembly; Bloom filter; Type 2
   diabetes
ID GUT MICROBIOTA; STAPHYLOCOCCUS-AUREUS; MULTIDRUG; GENOMES; GLUCOSE;
   GENERATION; RESISTANCE; METFORMIN; ALIGNMENT; GENES
AB Comparative metagenomics remains challenging due to the size and complexity of metagenomic datasets. Here we introduce subtractive assembly, a de novo assembly approach for comparative metagenomics that directly assembles only the differential reads that distinguish between two groups of metagenomes. Using simulated datasets, we show it improves both the efficiency of the assembly and the assembly quality of the differential genomes and genes. Further, its application to type 2 diabetes (T2D) metagenomic datasets reveals clear signatures of the T2D gut microbiome, revealing new phylogenetic and functional features of the gut microbial communities associated with T2D.
C1 [Wang, Mingjie; Ye, Yuzhen] Indiana Univ, Sch Informat & Comp, Bloomington, IN 47405 USA.
   [Doak, Thomas G.] Indiana Univ, Dept Biol, Bloomington, IN 47405 USA.
   [Doak, Thomas G.] Indiana Univ, Natl Ctr Genome Anal Support, Bloomington, IN 47401 USA.
C3 Indiana University System; Indiana University Bloomington; Indiana
   University System; Indiana University Bloomington; Indiana University
   System; Indiana University Bloomington
RP Ye, YZ (通讯作者)，Indiana Univ, Sch Informat & Comp, Bloomington, IN 47405 USA.
EM yye@indiana.edu
RI wang, ming/HPC-6329-2023
OI Doak, Thomas/0000-0001-5487-553X
FU National Science Foundation [DBI-0845685]; National Institute of Health
   [1R01AI108888-01A1]; Div Of Biological Infrastructure; Direct For
   Biological Sciences [1062432] Funding Source: National Science
   Foundation
FX This work was supported by National Science Foundation (grant number
   DBI-0845685) and National Institute of Health (grant number
   1R01AI108888-01A1).
CR Altschul SF, 1997, NUCLEIC ACIDS RES, V25, P3389, DOI 10.1093/nar/25.17.3389
   Angelakis E, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0010463
   Armougom F, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0007125
   Arndt D, 2012, NUCLEIC ACIDS RES, V40, pW88, DOI 10.1093/nar/gks497
   Becker MSL, 2009, DIABETES, V58, P745, DOI 10.2337/db08-1028
   Benson DA, 2010, NUCLEIC ACIDS RES, V38, pD46, DOI [10.1093/nar/gkp1024, 10.1093/nar/gks1195, 10.1093/nar/gkw1070, 10.1093/nar/gkq1079, 10.1093/nar/gkt1030, 10.1093/nar/gkx1094, 10.1093/nar/gkr1202, 10.1093/nar/gkn723]
   BLOOM BH, 1970, COMMUN ACM, V13, P422, DOI 10.1145/362686.362692
   Broder A., 2004, INTERNET MATH, V1, P485, DOI DOI 10.1080/15427951.2004.10129096
   Cao Y, 2014, BIOINFORMATICS, V30, P1674, DOI 10.1093/bioinformatics/btu104
   Coremans G, 2005, DIS COLON RECTUM, V48, P575, DOI 10.1007/s10350-004-0809-3
   David LA, 2014, NATURE, V505, P559, DOI 10.1038/nature12820
   Delcher AL, 2002, NUCLEIC ACIDS RES, V30, P2478, DOI 10.1093/nar/30.11.2478
   Deloger M, 2009, J BACTERIOL, V191, P91, DOI 10.1128/JB.01202-08
   den Besten G, 2013, AM J PHYSIOL-GASTR L, V305, pG900, DOI 10.1152/ajpgi.00265.2013
   Galperin MY, 2004, ENVIRON MICROBIOL, V6, P543, DOI 10.1111/j.1462-2920.2004.00652.x
   Gnerre S, 2011, P NATL ACAD SCI USA, V108, P1513, DOI 10.1073/pnas.1017351108
   Gurevich A, 2013, BIOINFORMATICS, V29, P1072, DOI 10.1093/bioinformatics/btt086
   Hamilton EJ, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0060502
   Hayakawa K, 2013, ANTIMICROB AGENTS CH, V57, P49, DOI 10.1128/AAC.01271-12
   Hingamp P, 2013, ISME J, V7, P1678, DOI 10.1038/ismej.2013.59
   Hintao J, 2007, ORAL MICROBIOL IMMUN, V22, P175, DOI 10.1111/j.1399-302X.2007.00341.x
   Huson DH, 2011, GENOME RES, V21, P1552, DOI 10.1101/gr.120618.111
   Huttenhower C, 2012, NATURE, V486, P207, DOI 10.1038/nature11234
   Jiang B, 2012, BMC GENOMICS, V13, DOI 10.1186/1471-2164-13-730
   Kaatz GW, 2005, ANTIMICROB AGENTS CH, V49, P1857, DOI 10.1128/AAC.49.5.1857-1864.2005
   Karlin S, 1997, J BACTERIOL, V179, P3899, DOI 10.1128/jb.179.12.3899-3913.1997
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Li H, 2009, BIOINFORMATICS, V25, P1094, DOI [10.1093/bioinformatics/btp324, 10.1093/bioinformatics/btp100]
   Mack M, 1998, J BACTERIOL, V180, P950, DOI 10.1128/JB.180.4.950-955.1998
   Maillet N, 2012, BMC BIOINFORMATICS, V13, DOI 10.1186/1471-2105-13-S19-S10
   Manges AR, 2010, J INFECT DIS, V202, P1877, DOI 10.1086/657319
   Marcais G, 2011, BIOINFORMATICS, V27, P764, DOI 10.1093/bioinformatics/btr011
   Markowitz VM, 2012, NUCLEIC ACIDS RES, V40, pD123, DOI 10.1093/nar/gkr975
   Mavromatis K, 2007, NAT METHODS, V4, P495, DOI 10.1038/nmeth1043
   McAleese F, 2005, ANTIMICROB AGENTS CH, V49, P1865, DOI 10.1128/AAC.49.5.1865-1871.2005
   Melsted P, 2011, BMC BIOINFORMATICS, V12, DOI 10.1186/1471-2105-12-333
   Mende DR, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0031386
   Michels F, 2007, ACTA ORTHOP BELG, V73, P263
   Modi SR, 2013, NATURE, V499, P219, DOI 10.1038/nature12212
   Muller LMAJ, 2005, CLIN INFECT DIS, V41, P281, DOI 10.1086/431587
   Musso G, 2011, ANNU REV MED, V62, P361, DOI 10.1146/annurev-med-012510-175505
   Nagarajan N, 2013, NAT REV GENET, V14, P157, DOI 10.1038/nrg3367
   Namiki T, 2012, NUCLEIC ACIDS RES, V40, DOI 10.1093/nar/gks678
   Ogata H, 1999, NUCLEIC ACIDS RES, V27, P29, DOI 10.1093/nar/27.1.29
   Omote H, 2006, TRENDS PHARMACOL SCI, V27, P587, DOI 10.1016/j.tips.2006.09.001
   Overbeek R, 2014, NUCLEIC ACIDS RES, V42, pD206, DOI 10.1093/nar/gkt1226
   Pell J, 2012, P NATL ACAD SCI USA, V109, P13272, DOI 10.1073/pnas.1121464109
   Peng Y, 2012, BIOINFORMATICS, V28, P1420, DOI 10.1093/bioinformatics/bts174
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Qin N, 2014, NATURE, V513, P59, DOI 10.1038/nature13568
   Rahman IU, 2010, J CLIN PHARM THER, V35, P685, DOI 10.1111/j.1365-2710.2009.01145.x
   Rho MN, 2010, NUCLEIC ACIDS RES, V38, DOI 10.1093/nar/gkq747
   Richter DC, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003373
   Sangwan N, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0046219
   Steffen MM, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0044002
   Stranneheim H, 2010, BIOINFORMATICS, V26, P1595, DOI 10.1093/bioinformatics/btq230
   Strimmer K, 2008, BIOINFORMATICS, V24, P1461, DOI 10.1093/bioinformatics/btn209
   Treangen TJ, 2013, GENOME BIOL, V14, DOI 10.1186/gb-2013-14-1-r2
   Tringe SG, 2005, SCIENCE, V308, P554, DOI 10.1126/science.1107851
   Tsuda M, 2009, MOL PHARMACOL, V75, P1280, DOI 10.1124/mol.109.056242
   van de Laar FA, 2005, DIABETES CARE, V28, P154, DOI 10.2337/diacare.28.1.154
   Veech R L, 1986, Adv Exp Med Biol, V194, P617
   Wang Y, 2012, J COMPUT BIOL, V19, P241, DOI 10.1089/cmb.2011.0276
   Wooley JC, 2010, J COMPUT SCI TECH-CH, V25, P71, DOI 10.1007/s11390-010-9306-4
   Xie W, 2011, ISME J, V5, P414, DOI 10.1038/ismej.2010.144
   Zhao YA, 2012, BIOINFORMATICS, V28, P125, DOI 10.1093/bioinformatics/btr595
NR 66
TC 7
Z9 7
U1 0
U2 15
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1474-760X
J9 GENOME BIOL
JI Genome Biol.
PD NOV 2
PY 2015
VL 16
AR 243
DI 10.1186/s13059-015-0804-0
PG 15
WC Biotechnology & Applied Microbiology; Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Genetics & Heredity
GA CW9KC
UT WOS:000365316600001
PM 26527161
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Ren, X
   Wang, LX
   Chen, ZL
   Zhang, M
   Hou, DZ
   Xue, Y
   Diao, XM
   Liu, RH
   Shen, Q
AF Ren, Xin
   Wang, Linxuan
   Chen, Zenglong
   Zhang, Min
   Hou, Dianzhi
   Xue, Yong
   Diao, Xianmin
   Liu, Ruihai
   Shen, Qun
TI Foxtail millet supplementation improves glucose metabolism and gut
   microbiota in rats with high-fat diet/streptozotocin-induced diabetes
SO FOOD SCIENCE AND HUMAN WELLNESS
LA English
DT Article
DE Foxtail millet; Glucose metabolism; Gut microbiota; Short-chain fatty
   acids
ID VITRO STARCH DIGESTIBILITY; IN-VITRO; PLASMA ADIPONECTIN;
   HDL-CHOLESTEROL; INSULIN LEVELS; DIETARY FIBER; WHOLE-GRAIN; TYPE-2;
   PROTEIN; ASSOCIATION
AB Foxtail millet (FM) whole grain has received special attention in recent years. To confirm the hypoglycemic effects of FM, we investigated the effects of FM supplementation on glucose metabolism and gut microbiota in rats with high-fat diet/streptozotocin (HFD/STZ)-induced diabetes. Specifically, we fully assessed the blood biochemical profiles, pancreatic histopathology, insulin-glucagon immunofluorescence, short-chain fatty acids, and gut microbiota composition of rats with HFD/STZ-induced diabetes before and after FM supplementation. Results showed that both 30% and 48% FM supplementation significantly decreased concentrations of fasting blood glucose, 60-min blood glucose, and blood triglycerides (P < 0.05); additionally, 48% FM supplementation significantly improved blood glucose tolerance and insulin resistance (P < 0.05). However, FM supplementation could not effectively repair damage to beta-cells over a short period of time. In addition, 4 weeks of 48% FM supplementation siginificantly increased the relative abundance of Bifidobacterium and concentration of butyrate, suggesting that the hypoglycemic effects of FM supplementation might be partially mediated by gut microbiota. Collectively, we found a dose-dependent relationship between FM supplementation and improvement of blood glucose metabolism, but did not find a synergistic effect between FM supplementation and metformin (Met) treatment. Our findings provide further support that consuming more whole-grain FM might be beneficial to individuals suffering from type 2 diabetes. (C) 2021 Beijing Academy of Food Sciences. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.
C1 [Ren, Xin; Wang, Linxuan; Zhang, Min] Beijing Technol & Business Univ, Beijing Adv Innovat Ctr Food Nutr & Human Hlth, Beijing Engn & Technol Res Ctr Food Addit, Beijing 100048, Peoples R China.
   [Ren, Xin; Hou, Dianzhi; Xue, Yong; Shen, Qun] China Agr Univ, Coll Food Sci & Nutr Engn, Natl Engn & Technol Res Ctr Fruits & Vegetables, Key Lab Plant Prot & Grain Proc, Beijing 100083, Peoples R China.
   [Chen, Zenglong] Chinese Acad Sci, Inst Zool, State Key Lab Integrated Management Pest Insects, Beijing 100101, Peoples R China.
   [Diao, Xianmin] Chinese Acad Agr Sci, Beijing 100081, Peoples R China.
   [Liu, Ruihai] Cornell Univ, Inst Comparat & Environm Toxicol, Dept Food Sci, Ithaca, NY 14853 USA.
C3 Beijing Technology & Business University; China Agricultural University;
   Chinese Academy of Sciences; Institute of Zoology, CAS; Chinese Academy
   of Agricultural Sciences; Cornell University
RP Shen, Q (通讯作者)，China Agr Univ, Coll Food Sci & Nutr Engn, Beijing 100083, Peoples R China.
EM shenqun@cau.edu.cn
RI chen, zenglong/E-1604-2015
OI Shen, Qun/0000-0002-2154-6104
FU National Key R&D Program of China [2017YFD0401200]; China Agriculture
   Research System [CARS-07-13.5-A17]; General S&T project of Beijing
   Municipal Commission of Education [KM202010011006]; BTBU Youth Fund
   [PXM2019_014213_000007]
FX This work was supported by the National Key R&D Program of China
   (2017YFD0401200), China Agriculture Research System (CARS-07-13.5-A17),
   General S&T project of Beijing Municipal Commission of Education
   (KM202010011006), and BTBU Youth Fund (PXM2019_014213_000007). The
   authors declare no conflict of interest.
CR Amer Diabet Associat, 2008, DIABETES CARE, V31, pS61, DOI 10.2337/dc08-S061
   Chandalia M, 2000, NEW ENGL J MED, V342, P1392, DOI 10.1056/NEJM200005113421903
   Cheng JT, 2006, DIABETES, V55, P819, DOI 10.2337/diabetes.55.03.06.db05-0934
   [中华医学会糖尿病学分会 Chinese Diabetes Society], 2018, [中国实用内科杂志, Chinese Journal of Practical Internal Medicine], V38, P292
   Choi YY, 2005, BIOSCI BIOTECH BIOCH, V69, P31, DOI 10.1271/bbb.69.31
   Dong JL, 2019, J SCI FOOD AGR, V99, P3886, DOI 10.1002/jsfa.9611
   Evert AB, 2014, DIABETES CARE, V37, pS120, DOI 10.2337/dc14-S120
   Gurung M, 2020, EBIOMEDICINE, V51, DOI 10.1016/j.ebiom.2019.11.051
   Han F, 2018, J AGR FOOD CHEM, V66, P6326, DOI 10.1021/acs.jafc.8b01891
   Hao HJ, 2013, BIOCHEM BIOPH RES CO, V436, P418, DOI 10.1016/j.bbrc.2013.05.117
   Houghton D, 2018, DIABETOLOGIA, V61, P1700, DOI 10.1007/s00125-018-4632-0
   Hu Y, 2020, BMJ-BRIT MED J, V370, DOI 10.1136/bmj.m2206
   Karas M, 2019, NUTRIENTS, V11, DOI 10.3390/nu11030550
   Kim SH, 2014, J APPL MICROBIOL, V117, P834, DOI 10.1111/jam.12573
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Lee HC, 2019, FOOD FUNCT, V10, P786, DOI 10.1039/c8fo02423e
   Ley SH, 2014, LANCET, V383, P1999, DOI 10.1016/S0140-6736(14)60613-9
   Li S, 2019, J FUNCT FOODS, V59, P49, DOI 10.1016/j.jff.2019.05.030
   Magne F, 2020, NUTRIENTS, V12, DOI 10.3390/nu12051474
   Makki K, 2018, CELL HOST MICROBE, V23, P705, DOI 10.1016/j.chom.2018.05.012
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Montonen J, 2003, AM J CLIN NUTR, V77, P622, DOI 10.1093/ajcn/77.3.622
   Nishizawa N, 2009, BIOSCI BIOTECH BIOCH, V73, P351, DOI 10.1271/bbb.80589
   Park KO, 2008, BIOSCI BIOTECH BIOCH, V72, P2918, DOI 10.1271/bbb.80395
   Pradeep PM, 2018, FOOD CHEM, V247, P46, DOI 10.1016/j.foodchem.2017.11.103
   Pryde SE, 2002, FEMS MICROBIOL LETT, V217, P133, DOI 10.1111/j.1574-6968.2002.tb11467.x
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Reimer RA, 2011, NUTR RES, V31, P296, DOI 10.1016/j.nutres.2011.03.012
   Ren X, 2018, NUTRIENTS, V10, DOI 10.3390/nu10101509
   Ren X, 2016, J CEREAL SCI, V69, P166, DOI 10.1016/j.jcs.2016.03.007
   Ren X, 2016, FOOD FUNCT, V7, P372, DOI [10.1039/c5fo01074h, 10.1039/C5FO01074H]
   Saeedi P, 2019, DIABETES RES CLIN PR, V157, DOI 10.1016/j.diabres.2019.107843
   Saleh ASM, 2013, COMPR REV FOOD SCI F, V12, P281, DOI 10.1111/1541-4337.12012
   Sharma B, 2019, INT J BIOL MACROMOL, V141, P117, DOI 10.1016/j.ijbiomac.2019.08.252
   Sharma S, 2018, FOOD CHEM, V245, P863, DOI 10.1016/j.foodchem.2017.11.093
   Sirtori CR, 1998, ATHEROSCLEROSIS, V137, P419, DOI 10.1016/S0021-9150(97)00298-0
   Srinivasan K, 2005, PHARMACOL RES, V52, P313, DOI 10.1016/j.phrs.2005.05.004
   Talukder S, 2015, CRIT REV FOOD SCI, V55, P735, DOI 10.1080/10408398.2012.674072
   Wang P, 2020, INT J OBESITY, V44, P213, DOI 10.1038/s41366-019-0332-1
   Wang SS, 2016, J ZHEJIANG UNIV-SC B, V17, P649, DOI 10.1631/jzus.B1600341
   Xi P, 2016, MOL NUTR FOOD RES, V60, P1819, DOI 10.1002/mnfr.201500963
   Yang RP, 2020, J AGR FOOD CHEM, V68, P3506, DOI 10.1021/acs.jafc.0c00370
   Zhang AX, 2015, CEREAL CHEM, V92, P455, DOI 10.1094/CCHEM-12-14-0252-R
   Zhang CG, 2019, FOOD SCI HUM WELL, V8, P102, DOI 10.1016/j.fshw.2019.03.007
   Zhang LZ, 2015, FOOD CHEM, V174, P495, DOI 10.1016/j.foodchem.2014.09.089
   Zhao GH, 2006, BIOMED CHROMATOGR, V20, P674, DOI 10.1002/bmc.580
   Zhao LJ, 2019, ENDOCRINE, V66, P526, DOI 10.1007/s12020-019-02103-8
   Zhu LH, 2020, CELL METAB, V31, P1068, DOI 10.1016/j.cmet.2020.04.021
NR 48
TC 10
Z9 10
U1 13
U2 69
PU KEAI PUBLISHING LTD
PI BEIJING
PA 16 DONGHUANGCHENGGEN NORTH ST, BEIJING, DONGHENG DISTRICT 100717,
   PEOPLES R CHINA
EI 2213-4530
J9 FOOD SCI HUM WELL
JI Food Sci. Human Wellness
PD JAN
PY 2022
VL 11
IS 1
BP 119
EP 128
DI 10.1016/j.fshw.2021.07.013
PG 10
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA UP7BG
UT WOS:000695531000013
OA gold
DA 2023-06-08
ER

PT J
AU Chu, SZ
   Zhang, F
   Wang, HY
   Xie, LJ
   Chen, ZA
   Zeng, WM
   Zhou, ZG
   Hu, F
AF Chu, Shuzhou
   Zhang, Feng
   Wang, Huiying
   Xie, Lijun
   Chen, Zhinan
   Zeng, Weimin
   Zhou, Zhiguang
   Hu, Fang
TI Aqueous Extract of Guava (Psidium guajava L.) Leaf Ameliorates
   Hyperglycemia by Promoting Hepatic Glycogen Synthesis and Modulating Gut
   Microbiota
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE guava leaf; hyperglycemia; liver; glucose metabolism; gut microbiota
ID INSULIN-RESISTANCE; AKKERMANSIA-MUCINIPHILA; METFORMIN ALTERS;
   GLUCOSE-UPTAKE; BODY-WEIGHT; INHIBITION; EXPRESSION; GLYCOSIDES;
   BUTYRATE; OBESITY
AB Type 2 diabetes mellitus (T2DM) is a major global health concern. Psidium guajava L. (guava) is widely used for food as well as a folk medicine. Previous studies have shown its anti-diabetic and anti-inflammatory properties. However, the underlying mechanisms remains to be elusive. In this study, we assessed the potential therapeutic effects of aqueous extract of guava leaves (GvAEx) on T2DM and explored their potential mechanisms in vivo and in vitro. GvAEx was gavage administered for 12 weeks in diabetic db/db mice. Our results have demonstrated that GvAEx significantly lowered fasting plasma glucose levels (p < 0.01) and improved glucose tolerance and insulin sensitivity (p < 0.01, p < 0.05, respectively). Additionally, GvAEx increased hepatic glycogen accumulation, glucose uptake and decreased the mRNA expression levels of gluconeogenic genes. Furthermore, GvAEx-treatment caused higher glucose transporter 2 (GLUT2) expression in the membrane in hepatocytes. Notably, for the first time, we have elaborated the possible mechanism of the hypoglycemic effect of GvAEx from the perspective of intestinal microbiota. GvAEx has significantly changed the composition of microbiota and increased short chain fatty acid (SCFA) -producing Lachnospiraceae family and Akkermansia genus in the gut. Taken together, GvAEx could alleviate hyperglycemia and insulin resistance of T2DM by regulating glucose metabolism in the liver and restoring the gut microbiota. Thus, GvAEx has the potential for drug development against T2DM.
C1 [Chu, Shuzhou; Zhang, Feng; Wang, Huiying; Xie, Lijun; Chen, Zhinan; Zhou, Zhiguang; Hu, Fang] Cent South Univ, Xiangya Hosp 2, Natl Clin Res Ctr Metab Dis, Metab Syndrome Res Ctr,Key Lab Diabet Immunol,Mini, Changsha, Peoples R China.
   [Zeng, Weimin] Cent South Univ, Sch Minerals Proc & Bioengn, Key Lab Biomet, Minist Educ, Changsha, Peoples R China.
C3 Central South University; Central South University
RP Hu, F (通讯作者)，Cent South Univ, Xiangya Hosp 2, Natl Clin Res Ctr Metab Dis, Metab Syndrome Res Ctr,Key Lab Diabet Immunol,Mini, Changsha, Peoples R China.
EM hu_fang98@csu.edu.cn
RI wang, hao/HSE-7975-2023; wang, huimin/HDM-8421-2022; wang,
   hui/HSG-6135-2023; wang, hui/GRS-4730-2022; Xie, li/HGE-6052-2022; wang,
   jian/HRB-9588-2023; Wang, Hui/HMU-9512-2023
CR Bai L, 2019, AM J CHINESE MED, V47, P933, DOI 10.1142/S0192415X19500496
   Balaich J, 2021, NATURE, V600, P110, DOI 10.1038/s41586-021-04091-0
   Bauer PV, 2018, CELL METAB, V27, P101, DOI 10.1016/j.cmet.2017.09.019
   Beidokhti MN, 2020, J ETHNOPHARMACOL, V257, DOI 10.1016/j.jep.2020.112877
   Canfora EE, 2015, NAT REV ENDOCRINOL, V11, P577, DOI 10.1038/nrendo.2015.128
   Chambers ES, 2015, GUT, V64, P1744, DOI 10.1136/gutjnl-2014-307913
   Cheng FC, 2009, J FOOD SCI, V74, pH132, DOI 10.1111/j.1750-3841.2009.01149.x
   Cho NH, 2018, DIABETES RES CLIN PR, V138, P271, DOI 10.1016/j.diabres.2018.02.023
   Dakappa S. S., 2013, Journal of Drug Delivery and Therapeutics, V3, P162
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   DeFronzo RA, 2015, INT TXB DIABETES MEL, V4th
   Deguchi Y, 2010, NUTR METAB, V7, DOI 10.1186/1743-7075-7-9
   Diaz-De-Cerio E, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18040897
   Ding Y, 2012, EUR FOOD RES TECHNOL, V234, P873, DOI 10.1007/s00217-012-1701-3
   Ding YY, 2016, EBIOMEDICINE, V7, P135, DOI 10.1016/j.ebiom.2016.04.002
   Eidenberger T, 2013, FITOTERAPIA, V89, P74, DOI 10.1016/j.fitote.2013.05.015
   Gao ZG, 2009, DIABETES, V58, P1509, DOI 10.2337/db08-1637
   Graessler J, 2013, PHARMACOGENOMICS J, V13, P514, DOI 10.1038/tpj.2012.43
   Guo L, 2021, J MOL LIQ, V327, DOI 10.1016/j.molliq.2020.114828
   Gurung M, 2020, EBIOMEDICINE, V51, DOI 10.1016/j.ebiom.2019.11.051
   Han HS, 2016, EXP MOL MED, V48, DOI 10.1038/emm.2015.122
   Hatting M, 2018, ANN NY ACAD SCI, V1411, P21, DOI 10.1111/nyas.13435
   Huang XJ, 2018, INT J BIOL SCI, V14, P1483, DOI 10.7150/ijbs.27173
   International Diabetes Federation-IDF, 2019, DIABETES ATLAS
   Jayachandran M, 2020, MOL BIOL REP, V47, P2793, DOI 10.1007/s11033-020-05399-2
   Jia RK, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.747646
   Kong XC, 2015, DIABETES, V64, P393, DOI 10.2337/db14-0395
   Kuang YS, 2017, GIGASCIENCE, V6, DOI 10.1093/gigascience/gix058
   Lee WK, 2006, CLIN EXP PHARMACOL P, V33, P27, DOI 10.1111/j.1440-1681.2006.04319.x
   Leighton E, 2017, DIABETES THER, V8, P475, DOI 10.1007/s13300-017-0265-4
   Ley RE, 2006, NATURE, V444, P1022, DOI 10.1038/4441022a
   Li H, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.788558
   Ma LY, 2020, GUT MICROBES, V12, DOI 10.1080/19490976.2020.1832857
   Mendez-Lucas A, 2013, J HEPATOL, V59, P105, DOI 10.1016/j.jhep.2013.02.020
   Morais-Braga MFB, 2016, J ETHNOPHARMACOL, V194, P1140, DOI 10.1016/j.jep.2016.11.017
   Morton J.F., 1987, FRUITS WARM CLIMATES
   Oh WK, 2005, J ETHNOPHARMACOL, V96, P411, DOI 10.1016/j.jep.2004.09.041
   Paoli P, 2013, BBA-GEN SUBJECTS, V1830, P3102, DOI 10.1016/j.bbagen.2013.01.017
   Petersen MC, 2018, PHYSIOL REV, V98, P2133, DOI 10.1152/physrev.00063.2017
   Petersen MC, 2017, NAT REV ENDOCRINOL, V13, P572, DOI 10.1038/nrendo.2017.80
   Prats C, 2018, J BIOL CHEM, V293, P7089, DOI 10.1074/jbc.R117.802843
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Rodriguez-Rodriguez C, 2015, FOOD FUNCT, V6, P805, DOI [10.1039/c4fo01092b, 10.1039/C4FO01092B]
   Rojas-Garbanzo C, 2017, FOOD RES INT, V100, P445, DOI 10.1016/j.foodres.2016.12.004
   Saad MJA, 2016, PHYSIOLOGY, V31, P283, DOI 10.1152/physiol.00041.2015
   Saemann MD, 2000, FASEB J, V14, P2380
   Sesti G, 2006, BEST PRACT RES CL EN, V20, P665, DOI 10.1016/j.beem.2006.09.007
   Shibayama J, 2019, BENEF MICROBES, V10, P811, DOI 10.3920/BM2019.0072
   Smith NK, 2019, NEUROCHEM INT, V128, P94, DOI 10.1016/j.neuint.2019.04.010
   Srivastava AK, 1998, MOL CELL BIOCHEM, V182, P135, DOI 10.1023/A:1006857527588
   Tan BC, 2022, COLLOID SURFACE A, V645, DOI 10.1016/j.colsurfa.2022.128892
   Tang XL, 2021, J BIOMED SCI, V28, DOI 10.1186/s12929-021-00711-z
   Thorens B, 2015, DIABETOLOGIA, V58, P221, DOI 10.1007/s00125-014-3451-1
   Vinayagam R, 2018, BIOMED PHARMACOTHER, V103, P1012, DOI 10.1016/j.biopha.2018.04.127
   Wang JF, 2018, GUT, V67, P1614, DOI 10.1136/gutjnl-2018-315988
   Wang KL, 2021, PHARMACOL RES PERSPE, V9, DOI 10.1002/prp2.765
   Wang Y, 2017, METABOLISM, V70, P72, DOI 10.1016/j.metabol.2017.02.003
   Wild S, 2004, DIABETES CARE, V27, P1047, DOI 10.2337/diacare.27.5.1047
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Xu J, 2015, ISME J, V9, P552, DOI 10.1038/ismej.2014.177
   Xu XZ, 2020, GENOM PROTEOM BIOINF, V18, P721, DOI [10.1016/j.gpb.2019.09.0071672-0229, 10.1016/j.gpb.2019.09.007]
   Yang Q, 2018, NAT REV MOL CELL BIO, V19, P654, DOI 10.1038/s41580-018-0044-8
   Yoshitomi H, 2012, NUTR METAB, V9, DOI 10.1186/1743-7075-9-13
   Yue SJ, 2019, FOOD FUNCT, V10, P7063, DOI 10.1039/c9fo01334b
   Zhang SS, 2021, MICROBIOL SPECTR, V9, DOI 10.1128/Spectrum.00223-21
   Zhang T, 2019, MICROB BIOTECHNOL, V12, P1109, DOI 10.1111/1751-7915.13410
   Zhang WY, 2012, J AGR FOOD CHEM, V60, P7652, DOI 10.1021/jf300601z
   Zhang X, 2015, SCI REP-UK, V5, DOI 10.1038/srep14405
   Zhang ZL, 2016, CARBOHYD POLYM, V144, P106, DOI 10.1016/j.carbpol.2016.02.030
   Zhao LP, 2018, SCIENCE, V359, P1151, DOI 10.1126/science.aao5774
NR 70
TC 5
Z9 5
U1 7
U2 20
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD JUN 1
PY 2022
VL 13
AR 907702
DI 10.3389/fphar.2022.907702
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 2D6WD
UT WOS:000811683700001
PM 35721172
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Wang, AR
   Zhang, Z
   Ding, QW
   Yang, YL
   Bindelle, J
   Ran, C
   Zhou, ZG
AF Wang, Anran
   Zhang, Zhen
   Ding, Qianwen
   Yang, Yalin
   Bindelle, Jerome
   Ran, Chao
   Zhou, Zhigang
TI Intestinal Cetobacterium and acetate modify glucose homeostasis via
   parasympathetic activation in zebrafish
SO GUT MICROBES
LA English
DT Article
DE Gut microbiota; Cetobacterium; acetate; glucose homeostasis; zebrafish
ID GUT MICROBIOTA; DIETARY CARBOHYDRATE; INSULIN-SECRETION; METABOLISM;
   FISH; GLUCAGON; GROWTH; EXPRESSION; NUTRITION; METFORMIN
AB The capability of carbohydrate utilization in fish is limited compared to mammals. It has scientific and practical significance to improve the ability of fish to use carbohydrates. The efficiency of dietary carbohydrate utilization varies among fish with different feeding habits, which are associated with differential intestinal microbiota. In this study, we found that zebrafish fed with omnivorous diet (OD) and herbivorous diet (HD) showed better glucose homeostasis compared with carnivorous diet (CD) fed counterpart and the differential glucose utilization efficiency was attributable to the intestinal microbiota. The commensal bacterium Cetobacterium somerae, an acetate producer, was enriched in OD and HD groups, and administration of C. somerae in both adult zebrafish and gnotobiotic larval zebrafish models resulted in improved glucose homeostasis and increased insulin expression, supporting a causative role of C. somerae enrichment in glucose homeostasis in fish. The enrichment of C. somerae was constantly associated with higher acetate levels, and dietary supplementation of acetate promotes glucose utilization in zebrafish, suggesting a contribution of acetate in the function of C. somerae. Furthermore, we found that the beneficial effect of both acetate and C. somerae on glucose homeostasis was mediated through parasympathetic activation. Overall, this work highlights the existence of a C. somerae-brain axis in the regulation of glucose homeostasis in fish and suggests a role of acetate in mediating the axis function. Our results suggest potential strategies for improvement of fish carbohydrate utilization.
C1 [Wang, Anran; Bindelle, Jerome] Liege Univ ULiege, AgroBioChem TERRA, Gembloux Agrobio Tech, Dept AgroBioChem,Precis Livestock & Nutr Unit, Gembloux, Belgium.
   [Wang, Anran; Zhou, Zhigang] Chinese Acad Agr Sci, Feed Res Inst, China Norway Joint Lab Fish Gastrointestinal Micr, Beijing, Peoples R China.
   [Zhang, Zhen; Yang, Yalin; Ran, Chao] Chinese Acad Agr Sci, Feed Res Inst, Key Lab Feed Biotechnol, Minist Agr, Beijing, Peoples R China.
   [Ding, Qianwen] Norwegian Univ Sci & Technol, Inst Biol, Norway China Joint Lab Fish Gastrointestinal Micr, Trondheim, Norway.
C3 Chinese Academy of Agricultural Sciences; Feed Research Institute, CAAS;
   Chinese Academy of Agricultural Sciences; Feed Research Institute, CAAS;
   Ministry of Agriculture & Rural Affairs; Norwegian University of Science
   & Technology (NTNU)
RP Zhou, ZG (通讯作者)，Chinese Acad Agr Sci, Feed Res Inst, China Norway Joint Lab Fish Gastrointestinal Micr, Beijing, Peoples R China.; Ran, C (通讯作者)，Chinese Acad Agr Sci, Feed Res Inst, Key Lab Feed Biotechnol, Minist Agr, Beijing, Peoples R China.
EM ranchao@caas.cn; zhouzhigang03@caas.cn
OI zhang, zhen/0000-0002-1644-5085; Ding, Qianwen/0000-0001-9182-6323;
   Bindelle, Jerome/0000-0001-6974-4313
FU National Natural Science Foundation of China [NSFC 31972807, 31872584,
   NSFC 31925038]; National Key R&D Program of China [2018YFD0900400];
   China Scholarship Council [CSC 202003250120]
FX This work was supported by the National Natural Science Foundation of
   China (NSFC 31925038), the National Key R&D Program of China
   (2018YFD0900400), National Natural Science Foundation of China (NSFC
   31972807, 31872584) and the China Scholarship Council (CSC
   202003250120).
CR Barbosa A., 2012, ZEBRAFISH PROTOCOLS, DOI [10.1007/978-1-61779-597-8_25, DOI 10.1007/978-1-61779-597-8_25]
   Briant L, 2016, UPSALA J MED SCI, V121, P113, DOI 10.3109/03009734.2016.1156789
   Butt RL, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00009
   De Vadder F, 2014, CELL, V156, P84, DOI 10.1016/j.cell.2013.12.016
   Ekmann KS, 2013, BRIT J NUTR, V109, P2135, DOI 10.1017/S000711451200445X
   Elo B, 2007, J MOL ENDOCRINOL, V38, P433, DOI 10.1677/JME-06-0037
   Enes P, 2011, REV FISH SCI, V19, P201, DOI 10.1080/10641262.2011.579363
   Fan Y, 2021, NAT REV MICROBIOL, V19, P55, DOI 10.1038/s41579-020-0433-9
   FOSTER G, 1995, LETT APPL MICROBIOL, V21, P202, DOI 10.1111/j.1472-765X.1995.tb01041.x
   Guo XZ, 2017, J NUTR, V147, P781, DOI 10.3945/jn.116.245506
   Hao YT, 2017, AQUAC RES, V48, P5595, DOI 10.1111/are.13381
   Hartstra AV, 2015, DIABETES CARE, V38, P159, DOI 10.2337/dc14-0769
   Hemre GI, 2002, AQUACULT NUTR, V8, P175, DOI 10.1046/j.1365-2095.2002.00200.x
   HERTZ Y, 1989, AQUACULTURE, V80, P175, DOI 10.1016/0044-8486(89)90283-4
   Hill JH, 2016, ELIFE, V5, DOI 10.7554/eLife.20145
   Ishihara H, 2003, NAT CELL BIOL, V5, P330, DOI 10.1038/ncb951
   Kim E, 2016, NUTR RES PRACT, V10, P11, DOI 10.4162/nrp.2016.10.1.11
   Larsen AM, 2014, J APPL MICROBIOL, V116, P1396, DOI 10.1111/jam.12475
   Le Roith D, 2001, DIABETES CARE, V24, P588, DOI 10.2337/diacare.24.3.588
   Liu JL, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21030910
   MOMMSEN TP, 1991, REV AQUAT SCI, V4, P225
   Moon TW, 2001, COMP BIOCHEM PHYS B, V129, P243, DOI 10.1016/S1096-4959(01)00316-5
   Mullapudi ST, 2018, ELIFE, V7, DOI 10.7554/eLife.42209
   Navarro I, 1999, COMP BIOCHEM PHYS B, V122, P137, DOI 10.1016/S0305-0491(98)10163-3
   Do HO, 2015, CLIN EXP PHARMACOL P, V42, P406, DOI 10.1111/1440-1681.12368
   Panserat S, 2000, J NUTR BIOCHEM, V11, P22, DOI 10.1016/S0955-2863(99)00067-4
   Panserat S., 2009, CURRENT STATUS MOL R
   Pedroso GL, 2012, JOVE-J VIS EXP, DOI 10.3791/3865
   Perry RJ, 2016, NATURE, V534, P213, DOI 10.1038/nature18309
   Pham LN, 2008, NAT PROTOC, V3, P1862, DOI 10.1038/nprot.2008.186
   Polakof S, 2009, AM J PHYSIOL-REG I, V297, pR1769, DOI 10.1152/ajpregu.00369.2009
   Polakof S, 2012, J COMP PHYSIOL B, V182, P1015, DOI 10.1007/s00360-012-0658-7
   Priyadarshini M, 2015, MOL ENDOCRINOL, V29, P1055, DOI 10.1210/me.2015-1007
   Ramakrishna BS, 2013, J GASTROEN HEPATOL, V28, P9, DOI 10.1111/jgh.12294
   Ramirez C, 2018, ANIMALS-BASEL, V8, DOI 10.3390/ani8110189
   Ran C, 2016, J NUTR, V146, P1132, DOI 10.3945/jn.115.229377
   Rawls JF, 2006, CELL, V127, P423, DOI 10.1016/j.cell.2006.08.043
   Roeselers G, 2011, ISME J, V5, P1595, DOI 10.1038/ismej.2011.38
   Rowland I, 2018, EUR J NUTR, V57, P1, DOI 10.1007/s00394-017-1445-8
   Sanna S, 2019, NAT GENET, V51, P600, DOI 10.1038/s41588-019-0350-x
   Shimizu H, 2019, GLYCATIVE STRESS RES, V6, P181, DOI [10.24659/gsr.6.3_181, DOI 10.24659/GSR.6.3_181, 10.24659/gsr.6.3181, DOI 10.24659/GSR.6.3181]
   Silva YP, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.00025
   Tilg H, 2011, J CLIN INVEST, V121, P2126, DOI 10.1172/JCI58109
   van Kessel MAHJ, 2011, AMB EXPRESS, V1, DOI 10.1186/2191-0855-1-41
   Vatsos IN, 2017, LAB ANIM-UK, V51, P353, DOI 10.1177/0023677216678825
   Wang AR, 2018, REV AQUACULT, V10, P626, DOI 10.1111/raq.12191
   WILSON RP, 1994, AQUACULTURE, V124, P67, DOI 10.1016/0044-8486(94)90363-8
   Yamazaki H, 2006, AM J PHYSIOL-ENDOC M, V290, pE26, DOI 10.1152/ajpendo.00149.2005
   Zhang HL, 2020, AQUACULTURE, V523, DOI 10.1016/j.aquaculture.2020.735188
   Zhang ML, 2014, P NATL ACAD SCI USA, V111, pE3708, DOI 10.1073/pnas.1406156111
   Zhang Z, 2019, COMMUN BIOL, V2, DOI 10.1038/s42003-019-0526-z
NR 51
TC 58
Z9 58
U1 30
U2 118
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1949-0976
EI 1949-0984
J9 GUT MICROBES
JI Gut Microbes
PD JAN 1
PY 2021
VL 13
IS 1
BP 1
EP 15
DI 10.1080/19490976.2021.1900996
PG 15
WC Gastroenterology & Hepatology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Microbiology
GA WK6NW
UT WOS:000709842700001
PM 33840371
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Zhong, LJ
   Xie, ZS
   Yang, H
   Li, P
   Xu, XJ
AF Zhong Ling-Jun
   Xie Zhi-Sheng
   Yang Hua
   Li Ping
   Xu Xiao-Jun
TI Moutan Cortex and Paeoniae Radix Rubra reverse high-fat-diet-induced
   metabolic disorder and restore gut microbiota homeostasis
SO CHINESE JOURNAL OF NATURAL MEDICINES
LA English
DT Article
DE Moutan Cortex; Paeoniae Radix Rubra; Insulin resistance; Gut microbiota
ID INSULIN-RESISTANCE; INDUCED OBESITY; GLUCOSE; INDIVIDUALS; METAGENOME;
   PHYSIOLOGY
AB The present study was designed to investigate the therapeutic effcts of Moutan Cortex (CM, root bark of Paeonia suffruticosa Andr) and Paeoniae Radix Rubra (PR, root of Paeonia veitchii Lynch) on metabolic disorders, focusing on the infuence of CM and PR on the obesity-related gut microbiota homeostasis. The diet-induced obese (DIO) mouse model was used to test the therapeutic effects of CM and PR. The mice were orally administered with CM and PR for 6 weeks, and oral glucose tolerance test (OGTT) and insulin tolerance test (ITT) were performed to evaluate the insulin sensitivity of the mice. Sterol-regulatory element binding proteins (SREBPs) and their target genes were measured by quantitative RT-PCR. High-throughput 16S ribosomal RNA (16S rRNA) gene sequencing technology was used to determine the composition of gut microbiota, and the metabolites in serum were analyzed by GC-MS. Our results indicated that CM and PR combination alleviated obese and insulin resistance in the DIO mice, leading to increased glucose uptake and gene expression in muscle and liver, and down-regulated SREBPs and their target genes in liver. Interesting, neither the CM-PR extracts, nor the major components of CM and PR did not affect SREBPs activity in cultured cells. Meanwhile, CM and PR significantly modulated the gut microbiota of the high-fat diet (HFD) treated mice, similar to metformin, and CM-PR reversed the overall microbiota composition similar to the normal chow diet (NCD) treated mice. In conclusion, our results provide novel mechanisms of action for the effects of CM and PR in treating DIO-induced dysregulation of sugar and lipid metabolism.
C1 [Zhong Ling-Jun; Xie Zhi-Sheng; Yang Hua; Li Ping; Xu Xiao-Jun] China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China.
   [Xu Xiao-Jun] China Pharmaceut Univ, Jiangsu Key Lab Drug Discovery Metab Dis, Nanjing 210009, Jiangsu, Peoples R China.
C3 China Pharmaceutical University; China Pharmaceutical University
RP Li, P; Xu, XJ (通讯作者)，China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China.; Xu, XJ (通讯作者)，China Pharmaceut Univ, Jiangsu Key Lab Drug Discovery Metab Dis, Nanjing 210009, Jiangsu, Peoples R China.
EM liping2004@126.com; xiaojunxu2000@163.com
RI Li, Ping/GYV-4914-2022
FU National Natural Science Foundation of China [81421005, 81274159];
   Specialized Research Fund of the Doctoral Program of Higher Education
   (SRFDP); Research Council Earmarked Research Grants (RCERG) [201300
   96140001]; Priority Academic Program Development of Jiangsu Higher
   Education Institutions (PAPD); New Century Excellent Talents in
   University [NCET-12-0976]; Creative Research Groups of China
FX This work was supported by the Fund for Creative Research Groups of
   China, National Natural Science Foundation of China (No. 81421005), the
   Specialized Research Fund of the Doctoral Program of Higher Education
   (SRFDP) and Research Council Earmarked Research Grants (RCERG) (No.
   201300 96140001), and the Priority Academic Program Development of
   Jiangsu Higher Education Institutions (PAPD). This work was also
   partially supported by the National Natural Science Foundation of China
   (No. 81274159). XU Xiao-Jun was supported by New Century Excellent
   Talents in University (NCET-12-0976).
CR Agius L, 2008, BIOCHEM J, V414, P1, DOI 10.1042/BJ20080595
   Backhed F, 2004, P NATL ACAD SCI USA, V101, P15718, DOI 10.1073/pnas.0407076101
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Chang CJ, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms8489
   Chiu CM, 2014, BIOMED RES INT, V2014, DOI 10.1155/2014/906168
   Chun SC, 2007, EVID-BASED COMPL ALT, V4, P327, DOI 10.1093/ecam/nel093
   Daniel H, 2014, ISME J, V8, P295, DOI 10.1038/ismej.2013.155
   Dao MC, 2016, GUT, V65, P426, DOI 10.1136/gutjnl-2014-308778
   Dethlefsen L, 2007, NATURE, V449, P811, DOI 10.1038/nature06245
   Ha DT, 2010, J ETHNOPHARMACOL, V131, P417, DOI 10.1016/j.jep.2010.07.010
   Dong XC, 2006, J CLIN INVEST, V116, P101, DOI 10.1172/JCI25735
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Fei N, 2013, ISME J, V7, P880, DOI 10.1038/ismej.2012.153
   Higuchi N, 2011, J CELL BIOCHEM, V112, P30, DOI 10.1002/jcb.22688
   Hill JO, 2012, CIRCULATION, V126, P126, DOI 10.1161/CIRCULATIONAHA.111.087213
   Huang YE, 2015, MICROB ECOL, V69, P407, DOI 10.1007/s00248-014-0487-1
   Jeon TI, 2012, TRENDS ENDOCRIN MET, V23, P65, DOI 10.1016/j.tem.2011.10.004
   Jia W, 2008, NAT REV DRUG DISCOV, V7, P123, DOI 10.1038/nrd2505
   Juan YC, 2011, J ETHNOPHARMACOL, V137, P592, DOI 10.1016/j.jep.2011.06.007
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kasai C, 2015, BMC GASTROENTEROL, V15, DOI 10.1186/s12876-015-0330-2
   Lau CH, 2007, PHYTOMEDICINE, V14, P778, DOI 10.1016/j.phymed.2007.01.007
   Le Chatelier E, 2013, NATURE, V500, P541, DOI 10.1038/nature12506
   Lin SJ, 2006, FOOD CHEM TOXICOL, V44, P2078, DOI 10.1016/j.fct.2006.07.010
   Luong TMN, 2012, J AGR FOOD CHEM, V60, P9062, DOI 10.1021/jf3035034
   Luong TMN, 2012, WORLD J MICROB BIOT, V28, P1575, DOI 10.1007/s11274-011-0961-6
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Reilly SM, 2013, NAT MED, V19, P313, DOI 10.1038/nm.3082
   Ridaura VK, 2013, SCIENCE, V341, P1079, DOI 10.1126/science.1241214
   Riserus U, 2009, PROG LIPID RES, V48, P44, DOI 10.1016/j.plipres.2008.10.002
   Tang JJ, 2011, CELL METAB, V13, P44, DOI 10.1016/j.cmet.2010.12.004
   Nguyen TLA, 2015, DIS MODEL MECH, V8, P1, DOI 10.1242/dmm.017400
   Trompette A, 2014, NAT MED, V20, P159, DOI 10.1038/nm.3444
   Turnbaugh PJ, 2008, CELL HOST MICROBE, V3, P213, DOI 10.1016/j.chom.2008.02.015
   Turnbaugh PJ, 2009, NATURE, V457, P480, DOI 10.1038/nature07540
   USA American Diabetes Association, 2004, Diabetes Care, V27, pS36
   Vrieze A, 2012, GASTROENTEROLOGY, V143, P913, DOI 10.1053/j.gastro.2012.06.031
   Wang FZ, 2015, BIOMATERIALS, V73, P149, DOI 10.1016/j.biomaterials.2015.09.013
   Wu GD, 2011, SCIENCE, V334, P105, DOI 10.1126/science.1208344
   Xie WD, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0024520
   Xie ZS, 2015, J ETHNOPHARMACOL, V172, P70, DOI 10.1016/j.jep.2015.05.041
   Xiong T, 2020, SENSOR ACTUAT B-CHEM, V304, DOI [10.1126/scitranslmed.3009124, 10.1016/j.snb.2019.127310]
   Xu J, 2015, ISME J, V9, P552, DOI 10.1038/ismej.2014.177
   Xu X, 2012, PLOS GENET, V8, DOI 10.1371/journal.pgen.1003108
   Yoshimoto S, 2013, NATURE, V499, P97, DOI 10.1038/nature12347
   Zhang CH, 2012, ISME J, V6, P1848, DOI 10.1038/ismej.2012.27
   Zhang CH, 2010, ISME J, V4, P232, DOI 10.1038/ismej.2009.112
   Zhang X, 2012, PLOS ONE, V7, DOI [10.1371/journal.pone.0040320, 10.1371/journal.pone.0042529]
   Zhao LP, 2013, NAT REV MICROBIOL, V11, P639, DOI 10.1038/nrmicro3089
   Zhao L, 2012, J PROTEOME RES, V11, P3509, DOI 10.1021/pr3001628
NR 50
TC 12
Z9 17
U1 1
U2 33
PU CHINESE JOURNAL NATURAL MEDICINES
PI NANJING
PA 24, TONGJIA XIANG, NANJING, 210009, PEOPLES R CHINA
SN 2095-6975
EI 1875-5364
J9 CHIN J NAT MEDICINES
JI Chin. J. Nat. Med.
PD MAR
PY 2017
VL 15
IS 3
BP 210
EP 219
PG 10
WC Integrative & Complementary Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine; Pharmacology & Pharmacy
GA EW4JL
UT WOS:000402467700006
PM 28411689
DA 2023-06-08
ER

PT J
AU Zhang, YW
   Cao, MM
   Li, YJ
   Chen, XX
   Yu, Q
   Rui, YF
AF Zhang, Yuan-Wei
   Cao, Mu-Min
   Li, Ying-Juan
   Chen, Xiang-Xu
   Yu, Qian
   Rui, Yun-Feng
TI A narrative review of the moderating effects and repercussion of
   exercise intervention on osteoporosis: ingenious involvement of gut
   microbiota and its metabolites
SO JOURNAL OF TRANSLATIONAL MEDICINE
LA English
DT Review
DE Exercise intervention; Bone; Osteoporosis; Gut microbiota; Metabolites
ID INTESTINAL BARRIER; METFORMIN TREATMENT; PHYSICAL-ACTIVITY;
   DOUBLE-BLIND; BILE-ACIDS; BONE LOSS; VOLUNTARY; BUTYRATE; INCREASES;
   DISEASE
AB Osteoporosis (OP) is a systemic bone disease characterized by the decreased bone mass and destruction of bone microstructure, which tends to result in the enhanced bone fragility and related fractures, as well as high disability rate and mortality. Exercise is one of the most common, reliable and cost-effective interventions for the prevention and treatment of OP currently, and numerous studies have revealed the close association between gut microbiota (GM) and bone metabolism recently. Moreover, exercise can alter the structure, composition and abundance of GM, and further influence the body health via GM and its metabolites, and the changes of GM also depend on the choice of exercise modes. Herein, combined with relevant studies and based on the inseparable relationship between exercise intervention-GM-OP, this review is aimed to discuss the moderating effects and potential mechanisms of exercise intervention on GM and bone metabolism, as well as the interaction between them.
C1 [Zhang, Yuan-Wei; Cao, Mu-Min; Chen, Xiang-Xu; Rui, Yun-Feng] Southeast Univ, Zhongda Hosp, Sch Med, Dept Orthopaed, 87 Ding Jia Qiao, Nanjing 210009, Jiangsu, Peoples R China.
   [Zhang, Yuan-Wei; Cao, Mu-Min; Li, Ying-Juan; Chen, Xiang-Xu; Yu, Qian; Rui, Yun-Feng] Southeast Univ, Zhongda Hosp, Sch Med, Multidisciplinary Team MDT Geriatr Hip Fracture M, Nanjing, Jiangsu, Peoples R China.
   [Zhang, Yuan-Wei; Cao, Mu-Min; Chen, Xiang-Xu; Rui, Yun-Feng] Southeast Univ, Sch Med, Nanjing, Jiangsu, Peoples R China.
   [Zhang, Yuan-Wei; Cao, Mu-Min; Chen, Xiang-Xu; Rui, Yun-Feng] Southeast Univ, Orthopaed Trauma Inst OTI, Nanjing, Jiangsu, Peoples R China.
   [Li, Ying-Juan] Southeast Univ, Zhongda Hosp, Sch Med, Dept Geriatr, Nanjing, Jiangsu, Peoples R China.
   [Yu, Qian] Southeast Univ, Zhongda Hosp, Sch Med, Dept Gastroenterol, Nanjing, Jiangsu, Peoples R China.
C3 Southeast University - China; Southeast University - China; Southeast
   University - China; Southeast University - China; Southeast University -
   China; Southeast University - China
RP Rui, YF (通讯作者)，Southeast Univ, Zhongda Hosp, Sch Med, Dept Orthopaed, 87 Ding Jia Qiao, Nanjing 210009, Jiangsu, Peoples R China.; Rui, YF (通讯作者)，Southeast Univ, Zhongda Hosp, Sch Med, Multidisciplinary Team MDT Geriatr Hip Fracture M, Nanjing, Jiangsu, Peoples R China.; Rui, YF (通讯作者)，Southeast Univ, Sch Med, Nanjing, Jiangsu, Peoples R China.; Rui, YF (通讯作者)，Southeast Univ, Orthopaed Trauma Inst OTI, Nanjing, Jiangsu, Peoples R China.
EM ruiyunfeng@126.com
FU Winfast Charity Foundation Project [YL20220525]; Jiangsu Provincial
   Medical Talent, The Project of Invigorating Health Care through Science,
   Technology and Education [ZDRCA2016083]; Jiangsu Elderly Health Research
   Project, Key Project of Elderly Health Research Project [LKZ2022010]
FX This current work was supported by grants from Winfast Charity
   Foundation Project (YL20220525); Jiangsu Provincial Medical Talent, The
   Project of Invigorating Health Care through Science, Technology and
   Education (ZDRCA2016083); and Jiangsu Elderly Health Research Project,
   Key Project of Elderly Health Research Project (LKZ2022010).
CR Abulfadle KA, 2023, ANAT SCI INT, V98, P22, DOI 10.1007/s12565-022-00666-7
   Alison JA, 2019, EUR RESPIR J, V53, DOI 10.1183/13993003.02429-2018
   Allegrante JP, 2019, ANNU REV PUBL HEALTH, V40, P127, DOI 10.1146/annurev-publhealth-040218-044008
   Allen JM, 2018, MED SCI SPORT EXER, V50, P747, DOI [10.1249/MSS.0000000000001495, 10.1249/mss.0000000000001495]
   Allen JM, 2015, J APPL PHYSIOL, V118, P1059, DOI 10.1152/japplphysiol.01077.2014
   Anderson L, 2017, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD012264.pub2
   Aoki T, 2020, NUTRIENTS, V12, DOI 10.3390/nu12092508
   Axling U, 2020, NUTRIENTS, V12, DOI 10.3390/nu12051279
   Aya V, 2021, PLOS ONE, V16, DOI 10.1371/journal.pone.0247039
   Balducci S, 2010, NUTR METAB CARDIOVAS, V20, P608, DOI 10.1016/j.numecd.2009.04.015
   Barton W, 2018, GUT, V67, P625, DOI 10.1136/gutjnl-2016-313627
   Behera J, 2020, BONE, V135, DOI 10.1016/j.bone.2020.115317
   Bermon S, 2015, EXERC IMMUNOL REV, V21, P70
   Blasco T, 2021, NAT COMMUN, V12, DOI 10.1038/s41467-021-25056-x
   Boets E, 2017, J PHYSIOL-LONDON, V595, P541, DOI 10.1113/JP272613
   Brooke-Wavell K, 2022, BRIT J SPORT MED, V56, P837, DOI 10.1136/bjsports-2021-104634
   Cai J, 2022, CELL HOST MICROBE, V30, P289, DOI 10.1016/j.chom.2022.02.004
   Camilleri M, 2019, GUT, V68, P1516, DOI 10.1136/gutjnl-2019-318427
   Cella V, 2021, FOODS BASEL SWITZERL, V10
   Chen CY, 2010, EXERC SPORT SCI REV, V38, P122, DOI 10.1097/JES.0b013e3181e372b5
   Chen YC, 2017, J CLIN ENDOCR METAB, V102, P3635, DOI 10.1210/jc.2017-00513
   Chi L, 2021, GUT MICROBES, V13, DOI 10.1080/19490976.2021.1921912
   Clark A, 2017, FRONT PHYSIOL, V8, DOI 10.3389/fphys.2017.00319
   Clark A, 2016, J INT SOC SPORT NUTR, V13, DOI 10.1186/s12970-016-0155-6
   Clauss M, 2021, FRONT NUTR, V8, DOI 10.3389/fnut.2021.637010
   Codella R, 2018, DIGEST LIVER DIS, V50, P331, DOI 10.1016/j.dld.2017.11.016
   Conway J, 2021, AGEING RES REV, V68, DOI 10.1016/j.arr.2021.101323
   Cook MD, 2013, BRAIN BEHAV IMMUN, V33, P46, DOI 10.1016/j.bbi.2013.05.005
   da Silva CD, 2021, J INT SOC SPORT NUTR, V18, DOI 10.1186/s12970-020-00406-0
   Denou E, 2016, AM J PHYSIOL-ENDOC M, V310, pE982, DOI 10.1152/ajpendo.00537.2015
   Dokladny K, 2016, J APPL PHYSIOL, V120, P692, DOI 10.1152/japplphysiol.00536.2015
   Dorelli B, 2021, SYSTEMATIC REV NUTRI, V13
   Douglas JA, 2017, INT J OBESITY, V41, P1737, DOI 10.1038/ijo.2017.181
   Drakoularakou A, 2010, EUR J CLIN NUTR, V64, P146, DOI 10.1038/ejcn.2009.120
   Duijghuijsen LMJ, 2017, NUTRIENTS, V9, DOI 10.3390/nu9010084
   Fava F, 2019, P NUTR SOC, V78, P177, DOI 10.1017/S0029665118002719
   Feldman N, 2015, AGEING RES REV, V24, P29, DOI 10.1016/j.arr.2015.01.003
   Filip R, 2018, CLIN INTERV AGING, V13, P1879, DOI 10.2147/CIA.S170533
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Frampton J, 2020, NAT METAB, V2, P840, DOI 10.1038/s42255-020-0188-7
   Franzosa EA, 2019, NAT MICROBIOL, V4, P293, DOI 10.1038/s41564-018-0306-4
   Fuhrman BJ, 2014, J CLIN ENDOCR METAB, V99, P4632, DOI 10.1210/jc.2014-2222
   Fukiya S, 2009, FEMS MICROBIOL LETT, V293, P263, DOI 10.1111/j.1574-6968.2009.01531.x
   Gleeson M, 2011, INT J SPORT NUTR EXE, V21, P55, DOI 10.1123/ijsnem.21.1.55
   Gordon CJ, 2016, PHYSIOL BEHAV, V153, P56, DOI 10.1016/j.physbeh.2015.10.025
   Goto Y, 2014, IMMUNITY, V40, P594, DOI 10.1016/j.immuni.2014.03.005
   Grunig E, 2021, EUR HEART J, V42, P2284, DOI 10.1093/eurheartj/ehaa696
   Hamasaki H, 2017, J INTEGR MED-JIM, V15, P270, DOI 10.1016/S2095-4964(17)60342-X
   Hao X, 2022, BONE JOINT RES, V11, P214, DOI 10.1302/2046-3758.114.BJR-2021-0192.R1
   Hsu YJ, 2015, J STRENGTH COND RES, V29, P552, DOI 10.1519/JSC.0000000000000644
   Hughes RL, 2021, ADV NUTR, V12, P2190, DOI 10.1093/advances/nmab077
   Ilesanmi-Oyelere BL, 2021, JMIR RES PROTOC, V10, DOI 10.2196/30131
   Jang LG, 2019, J INT SOC SPORT NUTR, V16, DOI 10.1186/s12970-019-0290-y
   Jeukendrup AE, 2000, CLIN SCI, V98, P47, DOI 10.1042/CS19990258
   Kang SS, 2014, MOL NEURODEGENER, V9, DOI 10.1186/1750-1326-9-36
   Keirns BH, 2020, AM J PHYSIOL-GASTR L, V319, pG512, DOI 10.1152/ajpgi.00232.2020
   Kim D, 2019, FASEB J, V33, P5772, DOI 10.1096/fj.201802481R
   Kimmel DB, 2022, OSTEOPOROSIS INT, V33, P1125, DOI 10.1007/s00198-022-06308-y
   King MA, 2021, J APPL PHYSIOL, V130, P1754, DOI 10.1152/japplphysiol.00072.2021
   Kramer KM, 2000, BRAIN RES BULL, V53, P77
   Lahiri S, 2019, SCI TRANSL MED, V11, DOI 10.1126/scitranslmed.aan5662
   Larun L, 2015, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD003200.pub3
   Lei M, 2016, BENEF MICROBES, V7, P631, DOI 10.3920/BM2016.0067
   Lenoir M, 2020, GUT MICROBES, V12, P1, DOI 10.1080/19490976.2020.1826748
   Li J, 2021, BONE JOINT RES, V10, P51, DOI 10.1302/2046-3758.101.BJR-2020-0273.R1
   Li KF, 2021, SAUDI J BIOL SCI, V28, P40, DOI 10.1016/j.sjbs.2020.08.027
   Li Y, 2021, LIFE SCI, V269, DOI 10.1016/j.lfs.2021.119097
   Liang R, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0226240
   Lin H, 2019, J AGR FOOD CHEM, V67, P3624, DOI 10.1021/acs.jafc.9b00249
   Lin L, 2017, BMC IMMUNOL, V18, DOI 10.1186/s12865-016-0187-3
   Littman DR, 2018, CSH PERSPECT BIOL, V10, DOI 10.1101/cshperspect.a029355
   Liu CR, 2021, J CACHEXIA SARCOPENI, V12, P1393, DOI 10.1002/jcsm.12784
   Liu JH, 2021, ADV SCI, V8, DOI 10.1002/advs.202004831
   Loosen SH, 2022, Z GASTROENTEROL, V60, P1221, DOI 10.1055/a-1482-9236
   Luo BB, 2014, BRAIN BEHAV IMMUN, V39, P99, DOI 10.1016/j.bbi.2013.11.013
   Mahmoodzadeh S, 2021, J CACHEXIA SARCOPENI, V12, P1249, DOI 10.1002/jcsm.12749
   Mailing LJ, 2019, EXERC SPORT SCI REV, V47, P75, DOI 10.1249/JES.0000000000000183
   Malago JJ, 2005, CLIN EXP IMMUNOL, V141, P62, DOI 10.1111/j.1365-2249.2005.02810.x
   Matsumoto M, 2008, BIOSCI BIOTECH BIOCH, V72, P572, DOI 10.1271/bbb.70474
   McCabe LR, 2019, BONE, V118, P20, DOI 10.1016/j.bone.2018.03.024
   Meissner M, 2011, ATHEROSCLEROSIS, V218, P323, DOI 10.1016/j.atherosclerosis.2011.06.040
   Mok A, 2019, BMJ-BRIT MED J, V365, DOI 10.1136/bmj.l2323
   Monda V, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/3831972
   Mosinska P, 2018, DIGEST LIVER DIS, V50, P795, DOI 10.1016/j.dld.2018.05.016
   Motiani KK, 2020, MED SCI SPORT EXER, V52, P94, DOI 10.1249/MSS.0000000000002112
   Munukka Eveliina, 2018, Front Microbiol, V9, P2323, DOI 10.3389/fmicb.2018.02323
   Ng CA, 2021, OSTEOPOROSIS INT, V32, P893, DOI 10.1007/s00198-020-05723-3
   Nichols Andrew W, 2007, Curr Sports Med Rep, V6, P269, DOI 10.1007/s11932-007-0044-5
   Nilsson AG, 2018, J INTERN MED, V284, P307, DOI 10.1111/joim.12805
   O'Sullivan O, 2015, GUT MICROBES, V6, P131, DOI 10.1080/19490976.2015.1011875
   Ozaki D, 2021, OSTEOPOROSIS INT, V32, P145, DOI 10.1007/s00198-020-05728-y
   Pang B, 2021, FOOD FUNCT, V12, P5171, DOI [10.1039/D0FO03479G, 10.1039/d0fo03479g]
   Parhami F, 2000, ARTERIOSCL THROM VAS, V20, P2346, DOI 10.1161/01.ATV.20.11.2346
   Park JH, 2013, MENOPAUSE, V20, P747, DOI [10.1097/GME.0b013e31827cabca, 10.1097/gme.0b013e31827cabca]
   Pasini E, 2019, MINERVA MED, V110, P3, DOI 10.23736/S0026-4806.18.05589-1
   Pedersen BK, 2000, BRIT J SPORT MED, V34, P246, DOI 10.1136/bjsm.34.4.246
   Pedersini P, 2020, SCI TOTAL ENVIRON, V727, DOI 10.1016/j.scitotenv.2020.138648
   Peters HPF, 2001, GUT, V48, P435, DOI 10.1136/gut.48.3.435
   Pilmark NS, 2022, APPL PHYSIOL NUTR ME, V47, P309, DOI 10.1139/apnm-2021-0194
   Pires W, 2017, SPORTS MED, V47, P1389, DOI 10.1007/s40279-016-0654-2
   Portincasa P, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23031105
   Przewlocka K, 2020, NUTRIENTS, V12, DOI 10.3390/nu12051451
   Pyne DB, 2014, INT J SPORT PHYSIOL, V9, P744, DOI 10.1123/ijspp.2014-0232
   Calero CDQ, 2020, BENEF MICROBES, V11, P135, DOI 10.3920/BM2019.0076
   Quiroga R, 2020, EXP MOL MED, V52, P1048, DOI 10.1038/s12276-020-0459-0
   Rao KA, 2004, BRIT J SPORT MED, V38, P482, DOI 10.1136/bjsm.2003.006825
   Ribeiro FM, 2021, FRONT NUTR, V8, DOI 10.3389/fnut.2021.627289
   Rios JL, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-40601-x
   Rizzoli R, 2021, LANCET DIABETES ENDO, V9, P606, DOI 10.1016/S2213-8587(21)00119-4
   Scheiman J, 2019, NAT MED, V25, P1104, DOI 10.1038/s41591-019-0485-4
   Shimizu Y, 2018, WORLD J GASTROENTERO, V24, P4750, DOI 10.3748/wjg.v24.i42.4750
   Shulzhenko N, 2011, NAT MED, V17, P1585, DOI 10.1038/nm.2505
   Silva JPB, 2018, CURR PHARM DESIGN, V24, P4154, DOI 10.2174/1381612824666181001153605
   Sina C, 2018, SEMIN IMMUNOL, V37, P66, DOI 10.1016/j.smim.2018.02.008
   Sjogren K, 2012, J BONE MINER RES, V27, P1357, DOI 10.1002/jbmr.1588
   Sorrentino G, 2020, GASTROENTEROLOGY, V159, P956, DOI 10.1053/j.gastro.2020.05.067
   Stanghelle B, 2020, OSTEOPOROSIS INT, V31, P1069, DOI 10.1007/s00198-019-05256-4
   Tarantino G, 2014, J TRANSL MED, V12, DOI 10.1186/s12967-014-0214-1
   Tavakoly R, 2021, INT J SPORTS MED, V42, P769, DOI 10.1055/a-1463-3303
   Tobore TO, 2020, BEHAV BRAIN RES, V384, DOI 10.1016/j.bbr.2020.112560
   Tong XY, 2019, BIOMED RES INT, V2019, DOI 10.1155/2019/8171897
   Tu MY, 2020, NUTRIENTS, V12, DOI 10.3390/nu12113432
   Tu Y, 2021, J LEUKOCYTE BIOL, V110, P525, DOI 10.1002/JLB.3MR0321-755R
   van den Heuvel EGHM, 2000, J NUTR, V130, P2938, DOI 10.1093/jn/130.12.2938
   Velayati A, 2021, ARCH PHYSIOL BIOCHEM, DOI 10.1080/13813455.2021.1928225
   Venkatraman A, 2003, AM J PHYSIOL-GASTR L, V285, pG177, DOI 10.1152/ajpgi.00307.2002
   Vicentini FA, 2021, MICROBIOME, V9, DOI 10.1186/s40168-021-01165-z
   de Oliveira GLV, 2017, IMMUNOLOGY, V152, P1, DOI 10.1111/imm.12765
   Wallett A, 2022, INT J SPORT NUTR EXE, V32, P153, DOI 10.1123/ijsnem.2021-0150
   Wang JH, 2017, PEERJ, V5, DOI 10.7717/peerj.3450
   Wang J, 2022, DIABET METAB SYND OB, V15, P209, DOI 10.2147/DMSO.S346007
   Wang ZX, 2021, AM J CLIN NUTR, V114, P1304, DOI 10.1093/ajcn/nqab194
   Wei J, 2021, ARTHRITIS RHEUMATOL, V73, P1656, DOI 10.1002/art.41729
   Wen CL, 2021, MICROBIOME, V9, DOI 10.1186/s40168-021-01040-x
   Wu J, 2006, METABOLISM, V55, P423, DOI 10.1016/j.metabol.2005.10.002
   Xia WJ, 2021, GUT MICROBES, V13, P1, DOI 10.1080/19490976.2020.1854642
   Xu XM, 2019, J ORTHOP TRANSL, V18, P59, DOI 10.1016/j.jot.2018.11.003
   Yan J, 2016, P NATL ACAD SCI USA, V113, pE7554, DOI 10.1073/pnas.1607235113
   Yang J, 2022, GASTROENTEROLOGY, V162, P135, DOI 10.1053/j.gastro.2021.08.041
   Yang WJ, 2021, CELL MOL IMMUNOL, V18, P866, DOI 10.1038/s41423-021-00661-4
   Yu CX, 2019, J ENDOCRINOL, V243, P125, DOI 10.1530/JOE-19-0122
   Yuan Y, 2022, CELL PROLIFERAT, V55, DOI 10.1111/cpr.13194
   Zhang X, 2015, NAT MED, V21, P895, DOI 10.1038/nm.3914
   Zhang YW, 2022, J ORTHOP TRANSL, V37, P46, DOI 10.1016/j.jot.2022.08.003
   Zhang YW, 2023, PSYCHOL HEALTH MED, V28, P946, DOI 10.1080/13548506.2022.2119482
   Zhang YW, 2022, CRIT REV FOOD SCI, DOI 10.1080/10408398.2022.2047005
   Zhang YW, 2021, FOOD FUNCT, V12, P6442, DOI [10.1039/D1FO00825K, 10.1039/d1fo00825k]
   Zhang YW, 2021, FOOD FUNCT, V12, P5703, DOI [10.1039/d0fo03468a, 10.1039/D0FO03468A]
   Zhou C, 2020, J AUTOIMMUN, V107, DOI 10.1016/j.jaut.2019.102360
   Zhu YL, 2020, J ORTHOP TRANSL, V22, P7, DOI 10.1016/j.jot.2019.08.004
   Zouhal H, 2019, NUTR REV, V77, P455, DOI 10.1093/nutrit/nuz005
   Zuhl M, 2014, BRIT J SPORT MED, V48, P980, DOI 10.1136/bjsports-2012-091585
NR 152
TC 4
Z9 4
U1 8
U2 11
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1479-5876
J9 J TRANSL MED
JI J. Transl. Med.
PD OCT 27
PY 2022
VL 20
IS 1
AR 490
DI 10.1186/s12967-022-03700-4
PG 15
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 5T7WW
UT WOS:000876072600002
PM 36303163
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Debedat, J
   Clement, K
   Aron-Wisnewsky, J
AF Debedat, Jean
   Clement, Karine
   Aron-Wisnewsky, Judith
TI Gut Microbiota Dysbiosis in Human Obesity: Impact of Bariatric Surgery
SO CURRENT OBESITY REPORTS
LA English
DT Article
DE Bariatric surgery; Gut microbiota; Metagenomics; Richness; Obesity;
   Metabolism; Akkermansia muciniphila; Faecalibacterium prausnitzii;
   Microbial gene richness; Type-2 diabetes; Roux-en-Y gastric bypass;
   Sleeve gastrectomy; Adjustable gastric banding; Roseburia intestinalis;
   Proteobacteria; Gammaproteobacteria; Firmicutes; Bacteroidetes; BMI;
   HbA1c; Remission; Illumina
ID Y GASTRIC BYPASS; WEIGHT-LOSS; SLEEVE GASTRECTOMY; INTESTINAL
   MICROBIOTA; METFORMIN ALTERS; SERUM METABOLOME; DIETARY; MODULATION;
   DIVERSITY; RICHNESS
AB Purpose of ReviewIn this review, we summarize what is currently described in terms of gut microbiota (GM) dysbiosis modification post-bariatric surgery (BS) and their link with BS-induced clinical improvement. We also discuss how the major inter-individual variability in terms of GM changes could impact the clinical improvements seen in patients.Recent FindingsThe persisting increase in severe obesity prevalence has led to the subsequent burst in BS number. Indeed, it is to date the best treatment option to induce major and sustainable weight loss and metabolic improvement in these patients. During obesity, the gut microbiota displays distinctive features such as low microbial gene richness and compositional and functional alterations (termed dysbiosis) which have been associated with low-grade inflammation, increased body weight and fat mass, as well as type-2 diabetes. Interestingly, GM changes post-BS is currently being proposed as one the many mechanism explaining BS beneficial clinical outcomes.SummaryBS enables partial rescue of GM dysbiosis observed during obesity. Some of the GM characteristics modified post-BS (composition in terms of bacteria and functions) are linked to BS beneficial outcomes such as weight loss or metabolic improvements. Nevertheless, the changes in GM post-BS display major variability from one patient to the other. As such, further large sample size studies associated with GM transfer studies in animals are still needed to completely decipher the role of GM in the clinical improvements observed post-surgery.
C1 [Debedat, Jean; Clement, Karine; Aron-Wisnewsky, Judith] Sorbonne Univ, INSERM, NutriOm Res Unit, Paris, France.
   [Clement, Karine; Aron-Wisnewsky, Judith] Sorbonne Univ, Pitie Salpetriere Hosp, AP HP, Dept Nutr, 47-83 Bd Hop, F-75013 Paris, France.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   UDICE-French Research Universities; Sorbonne Universite; Assistance
   Publique Hopitaux Paris (APHP); Hopital Universitaire Paul-Brousse -
   APHP; Hopital Universitaire Pitie-Salpetriere - APHP; UDICE-French
   Research Universities; Sorbonne Universite; Hopital Universitaire
   Saint-Antoine - APHP; Universite Paris Cite; Hopital Universitaire
   Hotel-Dieu - APHP; Hopital Universitaire Saint-Louis - APHP
RP Clement, K; Aron-Wisnewsky, J (通讯作者)，Sorbonne Univ, INSERM, NutriOm Res Unit, Paris, France.; Clement, K; Aron-Wisnewsky, J (通讯作者)，Sorbonne Univ, Pitie Salpetriere Hosp, AP HP, Dept Nutr, 47-83 Bd Hop, F-75013 Paris, France.
EM karine.clement@inserm.fr; judith.aron-wisnewsky@psl.aphp.fr
RI ARON-WISNEWSKY, judith/AAH-7608-2020; Debédat, Jean/D-1661-2019
OI Debedat, Jean/0000-0002-8377-5965
FU European Union [HEALTH-F4-2012-305312, ANR-11-DPBS-0001]; Clinical
   research program (PHRC Microbaria); Institut Benjamin Delessert; Societe
   Francophone du Diabete (SFD); Fondation de France
FX Funding to support NutriOmics research unit activity on this review
   topic was obtained from European Union's Seventh Framework Program (FP7)
   for research, technological development, and demonstration under grant
   agreement HEALTH-F4-2012-305312 (Metacardis) and Metagenopolis grant
   ANR-11-DPBS-0001 and from the Clinical research program (PHRC
   Microbaria). JAW received grant from Institut Benjamin Delessert and
   Societe Francophone du Diabete (SFD), and KC received an award from the
   Fondation de France.
CR Abdennour M, 2014, J CLIN ENDOCR METAB, V99, P898, DOI 10.1210/jc.2013-3253
   Angrisani L, 2017, OBES SURG, V27, P2279, DOI 10.1007/s11695-017-2666-x
   Aron-Wisnewsky J, 2019, GUT, V68, P70, DOI 10.1136/gutjnl-2018-316103
   Aron-Wisnewsky J, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0149588
   Aron-Wisnewsky J, 2014, CURR ATHEROSCLER REP, V16, DOI 10.1007/s11883-014-0454-9
   Aron-Wisnewsky J, 2012, NAT REV GASTRO HEPAT, V9, P590, DOI 10.1038/nrgastro.2012.161
   Arora T, 2017, ISME J, V11, P2035, DOI 10.1038/ismej.2017.70
   Arthur JC, 2013, GUT MICROBES, V4, P253, DOI 10.4161/gmic.24220
   Arumugam M, 2011, NATURE, V473, P174, DOI 10.1038/nature09944
   Ashrafian H, 2011, OBES REV, V12, pe257, DOI 10.1111/j.1467-789X.2010.00802.x
   Bauer PV, 2018, CELL METAB, V27, P101, DOI 10.1016/j.cmet.2017.09.019
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   Cani PD, 2019, GUT, V68, P5, DOI 10.1136/gutjnl-2018-316815
   Caparros-Martin JA, 2017, MICROBIOME, V5, DOI 10.1186/s40168-017-0312-4
   Carvalho BM, 2012, DIABETOLOGIA, V55, P2823, DOI 10.1007/s00125-012-2648-4
   Castaner O, 2018, INT J ENDOCRINOL, V2018, DOI 10.1155/2018/4095789
   Cotillard A, 2013, NATURE, V500, P585, DOI 10.1038/nature12480
   Courcoulas AP, 2018, JAMA SURG, V153, P427, DOI 10.1001/jamasurg.2017.5025
   Courcoulas AP, 2015, SURG OBES RELAT DIS, V11, P1109, DOI 10.1016/j.soard.2015.01.011
   Dagan SS, 2017, OBES SURG, V27, P2258, DOI 10.1007/s11695-017-2633-6
   Damms-Machado A, 2015, BIOMED RES INT, V2015, DOI 10.1155/2015/806248
   Dao MC, 2016, GUT, V65, P426, DOI 10.1136/gutjnl-2014-308778
   Davies NK, 2019, SURG OBES RELAT DIS, V15, P656, DOI 10.1016/j.soard.2019.01.033
   De Filippo C, 2010, P NATL ACAD SCI USA, V107, P14691, DOI 10.1073/pnas.1005963107
   Debedat J, 2018, DIABETES CARE, V41, P2086, DOI 10.2337/dc18-0567
   Deschasaux M, 2018, NAT MED, V24, P1526, DOI 10.1038/s41591-018-0160-1
   Divoux A, 2010, DIABETES, V59, P2817, DOI 10.2337/db10-0585
   Duboc H, 2018, INT J OBESITY, V1, P428
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Falony G, 2016, SCIENCE, V352, P560, DOI 10.1126/science.aad3503
   Federico A, 2016, IN VIVO, V30, P321
   Fried M, 2014, OBES SURG, V24, P42, DOI 10.1007/s11695-013-1079-8
   Furet JP, 2010, DIABETES, V59, P3049, DOI 10.2337/db10-0253
   Godon JJ, 1997, APPL ENVIRON MICROB, V63, P2802, DOI 10.1128/AEM.63.7.2802-2813.1997
   Graessler J, 2013, PHARMACOGENOMICS J, V13, P514, DOI 10.1038/tpj.2012.43
   Griffin NW, 2017, CELL HOST MICROBE, V21, P84, DOI 10.1016/j.chom.2016.12.006
   Guo GL, 2018, NAT MED, V24, P1789, DOI 10.1038/s41591-018-0273-6
   Guo Y, 2019, J DIABETES, V11, P786, DOI 10.1111/1753-0407.12906
   Guo Y, 2018, EUR J ENDOCRINOL, V178, P43, DOI [10.1530/EJE-17-0403, 10.1530/eje-17-0403]
   Guo Y, 2017, DIABETES-METAB RES, V33, DOI 10.1002/dmrr.2857
   Kong LC, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0109434
   Kong LC, 2013, AM J CLIN NUTR, V98, P16, DOI 10.3945/ajcn.113.058743
   Laferrere B, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00530
   Lassen PB, 2017, J CLIN ENDOCR METAB, V102, P2443, DOI 10.1210/jc.2017-00138
   Le Chatelier E, 2013, NATURE, V500, P541, DOI 10.1038/nature12506
   le Roux CW, 2011, AM J PHYSIOL-REG I, V301, pR1057, DOI 10.1152/ajpregu.00139.2011
   Ley RE, 2005, P NATL ACAD SCI USA, V102, P11070, DOI 10.1073/pnas.0504978102
   Ley RE, 2006, NATURE, V444, P1022, DOI 10.1038/4441022a
   Li JV, 2011, GUT, V60, P1214, DOI 10.1136/gut.2010.234708
   Liou AP, 2013, SCI TRANSL MED, V5, DOI 10.1126/scitranslmed.3005687
   Liu RX, 2017, NAT MED, V23, P859, DOI 10.1038/nm.4358
   Magouliotis DE, 2017, OBES SURG, V27, P1345, DOI 10.1007/s11695-017-2595-8
   Manichanh C, 2006, GUT, V55, P205, DOI 10.1136/gut.2005.073817
   Marchesi JR, 2011, ENVIRON MICROBIOL, V13, P3088, DOI 10.1111/j.1462-2920.2011.02574.x
   Mingrone G, 2015, LANCET, V386, P964, DOI 10.1016/S0140-6736(15)00075-6
   Murphy R, 2017, OBES SURG, V27, P917, DOI 10.1007/s11695-016-2399-2
   Osland E, 2017, SURG LAPARO ENDO PER, V27, P8, DOI 10.1097/SLE.0000000000000374
   Osto M, 2013, PHYSIOL BEHAV, V119, P92, DOI 10.1016/j.physbeh.2013.06.008
   Paganelli FL, 2018, ROUX Y GASTRIC BYPAS, DOI [10.1101/395657, DOI 10.1101/395657]
   Palleja A, 2016, GENOME MED, V8, DOI 10.1186/s13073-016-0312-1
   Palmer C, 2007, PLOS BIOL, V5, P1556, DOI 10.1371/journal.pbio.0050177
   Patil DP, 2012, J BIOSCIENCES, V37, P647, DOI 10.1007/s12038-012-9244-0
   Patrone V, 2016, FRONT MICROBIOL, V7, DOI 10.3389/fmicb.2016.00200
   Pedersen HK, 2016, NATURE, V535, P376, DOI 10.1038/nature18646
   Penders J, 2006, PEDIATRICS, V118, P511, DOI 10.1542/peds.2005-2824
   Plovier H, 2017, NAT MED, V23, P107, DOI 10.1038/nm.4236
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Ridaura VK, 2013, SCIENCE, V341, P1079, DOI 10.1126/science.1241214
   Schauer PR, 2017, NEW ENGL J MED, V376, P641, DOI 10.1056/NEJMoa1600869
   Schwiertz A, 2010, OBESITY, V18, P190, DOI 10.1038/oby.2009.167
   Shao YK, 2017, OBES SURG, V27, P295, DOI 10.1007/s11695-016-2297-7
   Shendure J, 2008, NAT BIOTECHNOL, V26, P1135, DOI 10.1038/nbt1486
   Sjostrom L, 2012, JAMA-J AM MED ASSOC, V307, P56, DOI 10.1001/jama.2011.1914
   Thaiss CA, 2016, NATURE, V540, P544, DOI 10.1038/nature20796
   Thereaux J, 2015, SURG OBES RELAT DIS, V11, P19, DOI 10.1016/j.soard.2014.05.033
   Tremaroli V, 2015, CELL METAB, V22, P228, DOI 10.1016/j.cmet.2015.07.009
   Turnbaugh PJ, 2008, CELL HOST MICROBE, V3, P213, DOI 10.1016/j.chom.2008.02.015
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Turnbaugh PJ, 2009, NATURE, V457, P480, DOI 10.1038/nature07540
   Vandeputte D, 2017, NATURE, V551, P507, DOI 10.1038/nature24460
   Verger EO, 2016, OBES SURG, V26, P785, DOI 10.1007/s11695-015-1803-7
   Wang ZN, 2011, NATURE, V472, P57, DOI 10.1038/nature09922
   Ward EK, 2014, OBES SURG, V24, P1567, DOI 10.1007/s11695-014-1275-1
   Wu GD, 2011, SCIENCE, V334, P105, DOI 10.1126/science.1208344
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Yatsunenko T, 2012, NATURE, V486, P222, DOI 10.1038/nature11053
   Zhang HS, 2009, P NATL ACAD SCI USA, V106, P2365, DOI 10.1073/pnas.0812600106
NR 87
TC 60
Z9 61
U1 4
U2 34
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 2162-4968
J9 CURR OBES REP
JI Curr. Obes. Rep.
PD SEP
PY 2019
VL 8
IS 3
BP 229
EP 242
DI 10.1007/s13679-019-00351-3
PG 14
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA IL9XI
UT WOS:000477637900004
PM 31197613
OA Bronze, Green Submitted
DA 2023-06-08
ER

PT J
AU Bauer, PV
   Duca, FA
   Waise, TMZ
   Dranse, HJ
   Rasmussen, BA
   Puri, A
   Rasti, M
   O'Brien, CA
   Lam, TKT
AF Bauer, Paige V.
   Duca, Frank A.
   Waise, T. M. Zaved
   Dranse, Helen J.
   Rasmussen, Brittany A.
   Puri, Akshita
   Rasti, Mozhgan
   O'Brien, Catherine A.
   Lam, Tony K. T.
TI Lactobacillus gasseri in the Upper Small Intestine Impacts an
   ACSL3-Dependent Fatty Acid-Sensing Pathway Regulating Whole-Body Glucose
   Homeostasis
SO CELL METABOLISM
LA English
DT Article
ID GLUCAGON-LIKE PEPTIDE-1; BILE-SALT HYDROLASE; Y GASTRIC BYPASS; GUT
   MICROBIOTA; INSULIN SENSITIVITY; METABOLIC SYNDROME; NEURONAL NETWORK;
   METFORMIN ALTERS; GLP-1 SECRETION; OLEIC-ACID
AB Long-chain acyl-CoA synthetase (ACSL)-dependent upper small intestinal lipid metabolism activates pre-absorptive pathways to regulate metabolic homeostasis, but whether changes in the upper small intestinal microbiota alter specific fatty acid-dependent pathways to impact glucose homeostasis remains unknown. We here first find that upper small intestinal infusion of Intralipid, oleic acid, or linoleic acid pre-absorptively increases glucose tolerance and lowers glucose production in rodents. High-fat feeding impairs pre-absorptive fatty acid sensing and reduces upper small intestinal Lactobacillus gasseri levels and ACSL3 expression. Transplantation of healthy upper small intestinal microbiota to high-fat-fed rodents restores L. gasseri levels and fatty acid sensing via increased ACSL3 expression, while L. gasseri probiotic administration to non-transplanted high-fat-fed rodents is sufficient to restore upper small intestinal ACSL3 expression and fatty acid sensing. In summary, we unveil a glucoregulatory role of upper small intestinal L. gasseri that impacts an ACSL3-dependent glucoregulatory fatty acid-sensing pathway.
C1 [Bauer, Paige V.; Duca, Frank A.; Waise, T. M. Zaved; Dranse, Helen J.; Rasmussen, Brittany A.; Rasti, Mozhgan; Lam, Tony K. T.] Toronto Gen Hosp, MaRS Ctr, UHN, Res Inst, Toronto Med Discovery Tower,Room 10-705, Toronto, ON M5G 1L7, Canada.
   [Bauer, Paige V.; Rasmussen, Brittany A.; O'Brien, Catherine A.; Lam, Tony K. T.] Univ Toronto, Dept Physiol, Toronto, ON M5S 1A8, Canada.
   [Lam, Tony K. T.] Univ Toronto, Dept Med, Toronto, ON M5S 1A8, Canada.
   [Puri, Akshita; O'Brien, Catherine A.] Princess Margaret Canc Ctr, UHN, Toronto, ON M5G 2M9, Canada.
   [O'Brien, Catherine A.] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON M5S 1A8, Canada.
   [Lam, Tony K. T.] Univ Toronto, Banting & Best Diabet Ctr, Toronto, ON M5G 2C4, Canada.
C3 University of Toronto; University Health Network Toronto; Toronto
   General Hospital; University of Toronto; University of Toronto;
   University of Toronto; University Health Network Toronto; Princess
   Margaret Cancer Centre; University of Toronto; University of Toronto
RP Lam, TKT (通讯作者)，Toronto Gen Hosp, MaRS Ctr, UHN, Res Inst, Toronto Med Discovery Tower,Room 10-705, Toronto, ON M5G 1L7, Canada.; Lam, TKT (通讯作者)，Univ Toronto, Dept Physiol, Toronto, ON M5S 1A8, Canada.; Lam, TKT (通讯作者)，Univ Toronto, Dept Med, Toronto, ON M5S 1A8, Canada.; Lam, TKT (通讯作者)，Univ Toronto, Banting & Best Diabet Ctr, Toronto, ON M5G 2C4, Canada.
EM tony.lam@uhnres.utoronto.ca
RI WAISE, T M ZAVED/CAG-2483-2022
OI WAISE, T M ZAVED/0000-0002-0205-258X; O'Brien,
   Catherine/0000-0003-0682-3879
FU Canadian Institutes of Health Research (CIHR) Foundation [FDN-143204];
   Ontario Graduate Scholarship; Banting and Best Diabetes Center Graduate
   Studentship; Banting and Best Diabetes Center Post-Doctoral Fellowship;
   CIHR; Diabetes Canada post-doctoral fellowship
FX This work was supported by a Canadian Institutes of Health Research
   (CIHR) Foundation Grant to T.K.T.L. (FDN-143204). P.V.B. is supported by
   an Ontario Graduate Scholarship and a Banting and Best Diabetes Center
   Graduate Studentship. F.A.D. was a Banting Fellow. T.M.Z.W. is supported
   by a Banting and Best Diabetes Center Post-Doctoral Fellowship. H.J.D.
   is supported by a CIHR and a Diabetes Canada post-doctoral fellowship.
   B.A.R. was a Vanier Scholar. T.K.T.L. holds the John Kitson McIvor
   (1915-1942) Endowed Chair in Diabetes Research and the Canada Research
   Chair in Obesity at the Toronto General Hospital Research Institute and
   the University of Toronto.
CR Almiron M, 2013, CURR MICROBIOL, V67, P395, DOI 10.1007/s00284-013-0367-9
   Asemi Z, 2013, ANN NUTR METAB, V63, P1, DOI 10.1159/000349922
   Backhed F, 2004, P NATL ACAD SCI USA, V101, P15718, DOI 10.1073/pnas.0407076101
   Balakumar M., 2016, EUR J NUTR
   Bartram AK, 2011, APPL ENVIRON MICROB, V77, P3846, DOI 10.1128/AEM.02772-10
   Batterham RL, 2016, DIABETES CARE, V39, P893, DOI 10.2337/dc16-0145
   Bauer PV, 2018, CELL METAB, V27, P101, DOI 10.1016/j.cmet.2017.09.019
   Beysen C, 2012, DIABETOLOGIA, V55, P432, DOI 10.1007/s00125-011-2382-3
   Bowman TA, 2016, MOL METAB, V5, P210, DOI 10.1016/j.molmet.2016.01.001
   Breen DM, 2012, NAT MED, V18, P950, DOI 10.1038/nm.2745
   Breen DM, 2011, DIABETES, V60, P3148, DOI 10.2337/db11-0852
   BRUBAKER PL, 1991, ENDOCRINOLOGY, V128, P3175, DOI 10.1210/endo-128-6-3175
   Cani PD, 2006, DIABETES, V55, P1484, DOI 10.2337/db05-1360
   Cani PD, 2006, EUR J CLIN NUTR, V60, P567, DOI 10.1038/sj.ejcn.1602350
   Caporaso JG, 2010, NAT METHODS, V7, P335, DOI 10.1038/nmeth.f.303
   Chang CH, 2000, AM J PHYSIOL-GASTR L, V279, pG295, DOI 10.1152/ajpgi.2000.279.2.G295
   Cheung GWC, 2009, CELL METAB, V10, P99, DOI 10.1016/j.cmet.2009.07.005
   Chisholm C, 2002, AM J PHYSIOL-ENDOC M, V283, pE311, DOI 10.1152/ajpendo.00434.2001
   Choi SB, 2015, CRIT REV BIOTECHNOL, V35, P392, DOI 10.3109/07388551.2014.889077
   Clarysse S, 2009, J PHARM SCI-US, V98, P1177, DOI 10.1002/jps.21502
   Cote CD, 2015, NAT MED, V21, P498, DOI 10.1038/nm.3821
   Dailey MJ, 2011, AM J PHYSIOL-ENDOC M, V301, pE1184, DOI 10.1152/ajpendo.00335.2011
   David LA, 2014, NATURE, V505, P559, DOI 10.1038/nature12820
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   DeFronzo RA, 2009, DIABETES, V58, P773, DOI 10.2337/db09-9028
   Degirolamo C, 2014, CELL REP, V7, P12, DOI 10.1016/j.celrep.2014.02.032
   Derrien M, 2011, FRONT MICROBIOL, V2, DOI 10.3389/fmicb.2011.00166
   DeSantis TZ, 2006, APPL ENVIRON MICROB, V72, P5069, DOI 10.1128/AEM.03006-05
   Di Luccia B, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0134893
   Diakogiannaki E, 2013, DIABETOLOGIA, V56, P2688, DOI 10.1007/s00125-013-3037-3
   Duca FA, 2015, CELL METAB, V22, P367, DOI 10.1016/j.cmet.2015.07.003
   Duca FA, 2015, NAT MED, V21, P506, DOI 10.1038/nm.3787
   Ejtahed HS, 2012, NUTRITION, V28, P539, DOI 10.1016/j.nut.2011.08.013
   El Aidy S, 2013, GUT, V62, P1306, DOI 10.1136/gutjnl-2011-301955
   Everard A, 2013, BEST PRACT RES CL GA, V27, P73, DOI 10.1016/j.bpg.2013.03.007
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Gareau MG, 2011, MICROBIOL-SGM, V157, P2963, DOI 10.1099/mic.0.051094-0
   Giannakis M, 2009, J BIOL CHEM, V284, P30383, DOI 10.1074/jbc.M109.052738
   GREENBERG D, 1995, AM J PHYSIOL-REG I, V269, pR432, DOI 10.1152/ajpregu.1995.269.2.R432
   Gribble FM, 2003, DIABETES, V52, P1147, DOI 10.2337/diabetes.52.5.1147
   Gu S, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0083980
   Hansen L, 2000, AM J PHYSIOL-ENDOC M, V278, pE1010, DOI 10.1152/ajpendo.2000.278.6.E1010
   Hundal RS, 2000, DIABETES, V49, P2063, DOI 10.2337/diabetes.49.12.2063
   Iakoubov R, 2007, ENDOCRINOLOGY, V148, P1089, DOI 10.1210/en.2006-1403
   Iakoubov R, 2011, ENDOCRINOLOGY, V152, P1244, DOI 10.1210/en.2010-1352
   Jeun J, 2010, NUTRITION, V26, P321, DOI 10.1016/j.nut.2009.04.011
   Jiao J, 2013, DIABETES, V62, P1074, DOI 10.2337/db12-0681
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kokorovic A, 2011, GASTROENTEROLOGY, V141, P1720, DOI 10.1053/j.gastro.2011.06.042
   Kovatcheva-Datchary P, 2015, CELL METAB, V22, P971, DOI 10.1016/j.cmet.2015.10.001
   Kuhre RE, 2015, DIABETES, V64, P370, DOI 10.2337/db14-0807
   Kumar R, 2011, BRIT J NUTR, V105, P561, DOI 10.1017/S0007114510003740
   Lam TKT, 2010, NAT MED, V16, P392, DOI 10.1038/nm0410-392
   Le Chatelier E, 2013, NATURE, V500, P541, DOI 10.1038/nature12506
   Li F, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms3384
   Liu JH, 2015, BMC COMPLEM ALTERN M, V15, DOI 10.1186/s12906-015-0802-5
   Lye HS, 2017, J BIOTECHNOL, V262, P75, DOI 10.1016/j.jbiotec.2017.09.007
   MANSBACH CM, 1975, J CLIN INVEST, V56, P781, DOI 10.1172/JCI108156
   Marina AL, 2012, DIABETES CARE, V35, P1119, DOI 10.2337/dc11-2050
   Masella AP, 2012, BMC BIOINFORMATICS, V13, DOI 10.1186/1471-2105-13-31
   Mashek DG, 2006, J LIPID RES, V47, P2004, DOI 10.1194/jlr.M600150-JLR200
   Morgan K, 2004, J BIOL CHEM, V279, P31139, DOI 10.1074/jbc.M400458200
   Neyrinck AM, 2012, NUTR DIABETES, V2, DOI 10.1038/nutd.2011.24
   Parseus A, 2017, GUT, V66, P429, DOI 10.1136/gutjnl-2015-310283
   Perry RJ, 2016, NATURE, V534, P213, DOI 10.1038/nature18309
   Phifer CB, 1998, AM J PHYSIOL-REG I, V274, pR1725, DOI 10.1152/ajpregu.1998.274.6.R1725
   Plovier H, 2017, NAT MED, V23, P107, DOI 10.1038/nm.4236
   Prawitt J, 2011, DIABETES, V60, P1861, DOI 10.2337/db11-0030
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Rani RP, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.01004
   Rasmussen BA, 2012, GASTROENTEROLOGY, V142, P834, DOI 10.1053/j.gastro.2011.12.053
   Reimann F, 2008, CELL METAB, V8, P532, DOI 10.1016/j.cmet.2008.11.002
   Richards P, 2016, PEPTIDES, V77, P21, DOI 10.1016/j.peptides.2015.06.006
   Ridaura VK, 2013, SCIENCE, V341, P1079, DOI 10.1126/science.1241214
   Riserus U, 2009, PROG LIPID RES, V48, P44, DOI 10.1016/j.plipres.2008.10.002
   Rocca AS, 2001, ENDOCRINOLOGY, V142, P1148, DOI 10.1210/en.142.3.1148
   Roglic G., 2016, ISBN, V978, P92
   ROSSETTI L, 1990, DIABETES CARE, V13, P610, DOI 10.2337/diacare.13.6.610
   Sayin SI, 2013, CELL METAB, V17, P225, DOI 10.1016/j.cmet.2013.01.003
   Scherer T, 2012, J BIOL CHEM, V287, P33061, DOI 10.1074/jbc.M111.307348
   SCHIFF ER, 1972, J CLIN INVEST, V51, P1351, DOI 10.1172/JCI106931
   Segata N, 2011, GENOME BIOL, V12, DOI 10.1186/gb-2011-12-6-r60
   Shah BP, 2012, AM J PHYSIOL-CELL PH, V302, pC210, DOI 10.1152/ajpcell.00209.2011
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Soupene E, 2008, EXP BIOL MED, V233, P507, DOI 10.3181/0710-MR-287
   Thaler JP, 2012, J CLIN INVEST, V122, P153, DOI 10.1172/JCI59660
   Trabelsi MS, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms8629
   Tremaroli V, 2015, CELL METAB, V22, P228, DOI 10.1016/j.cmet.2015.07.009
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Turnbaugh PJ, 2009, SCI TRANSL MED, V1, DOI 10.1126/scitranslmed.3000322
   Uberuaga BP, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms9750
   Usman, 2001, J DAIRY RES, V68, P617, DOI 10.1017/S0022029901005179
   Vazquez-Baeza Y, 2013, GIGASCIENCE, V2, DOI 10.1186/2047-217X-2-16
   Vrieze A, 2012, GASTROENTEROLOGY, V143, P913, DOI 10.1053/j.gastro.2012.06.031
   Wang PYT, 2008, NATURE, V452, P1012, DOI 10.1038/nature06852
   Wang Q, 2007, APPL ENVIRON MICROB, V73, P5261, DOI 10.1128/AEM.00062-07
   Wang Z, 2012, APPL ENVIRON MICROB, V78, P8795, DOI 10.1128/AEM.02519-12
   Whelan Fiona J, 2014, Ann Am Thorac Soc, V11, P513, DOI 10.1513/AnnalsATS.201310-351OC
   Wirth R, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0110440
   WOLTMAN T, 1995, AM J PHYSIOL-REG I, V269, pR7, DOI 10.1152/ajpregu.1995.269.1.R7
   Woltman T, 1995, AM J PHYSIOL-REG I, V269, pR1420, DOI 10.1152/ajpregu.1995.269.6.R1420
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Xu FZ, 2016, ACTA CRYSTALLOGR F, V72, P376, DOI 10.1107/S2053230X16005707
   Yadav H, 2007, NUTRITION, V23, P62, DOI 10.1016/j.nut.2006.09.002
   Ye YZ, 2010, IEEE INT C BIOINFORM, P153, DOI 10.1109/BIBM.2010.5706555
   Yue JTY, 2016, NAT COMMUN, V7, DOI 10.1038/ncomms13501
   Zadeh-Tahmasebi M, 2016, J BIOL CHEM, V291, P8816, DOI 10.1074/jbc.M116.718460
   Zhou J, 2008, AM J PHYSIOL-ENDOC M, V295, pE1160, DOI 10.1152/ajpendo.90637.2008
NR 108
TC 42
Z9 45
U1 0
U2 37
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
SN 1550-4131
EI 1932-7420
J9 CELL METAB
JI Cell Metab.
PD MAR 6
PY 2018
VL 27
IS 3
BP 572
EP +
DI 10.1016/j.cmet.2018.01.013
PG 22
WC Cell Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Endocrinology & Metabolism
GA FY6EX
UT WOS:000426936200011
PM 29514066
OA Bronze
DA 2023-06-08
ER

PT J
AU Chen, JZ
   Hall, S
   Vitetta, L
AF Chen, Jiezhong
   Hall, Sean
   Vitetta, Luis
TI Altered gut microbial metabolites could mediate the effects of risk
   factors in Covid-19
SO REVIEWS IN MEDICAL VIROLOGY
LA English
DT Review
ID VITAMIN-D; INTESTINAL MICROBIOTA; METFORMIN TREATMENT; WIDE ASSOCIATION;
   T-CELLS; BUTYRATE; INFECTION; RECEPTOR; INFLAMMATION; METAGENOME
AB Coronavirus disease 2019 (Covid-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, is now pandemic. While most Covid-19 patients will experience mild symptoms, a small proportion will develop severe disease, which could be fatal. Clinically, Covid-19 patients manifest fever with dry cough, fatigue and dyspnoea, and in severe cases develop into acute respiratory distress syndrome (ARDS), sepsis and multi-organ failure. These severe patients are characterized by hyperinflammation with highly increased pro-inflammatory cytokines including IL-6, IL-17 and TNF-alpha as well as C-reactive protein, which are accompanied by decreased lymphocyte counts. Clinical evidence supports that gut microbiota dysregulation is common in Covid-19 and plays a key role in the pathogenesis of Covid-19. In this narrative review, we summarize the roles of intestinal dysbiosis in Covid-19 pathogenesis and posit that the associated mechanisms are being mediated by gut bacterial metabolites. Based on this premise, we propose possible clinical implications. Various risk factors could be causal for severe Covid-19, and these include advanced age, concomitant chronic disease, SARS-CoV-2 infection of enterocytes, use of antibiotics and psychological distress. Gut dysbiosis is associated with risk factors and severe Covid-19 due to decreased commensal microbial metabolites, which cause reduced anti-inflammatory mechanisms and chronic low-grade inflammation. The preconditioned immune dysregulation enables SARS-CoV-2 infection to progress to an uncontrolled hyperinflammatory response. Thus, a pre-existing gut microbiota that is diverse and abundant could be beneficial for the prevention of severe Covid-19, and supplementation with commensal microbial metabolites may facilitate and augment the treatment of severe Covid-19.
C1 [Chen, Jiezhong; Hall, Sean; Vitetta, Luis] Medlab Clin, Res Dept, Sydney, NSW, Australia.
   [Vitetta, Luis] Univ Sydney, Fac Med & Hlth, Sydney, NSW, Australia.
C3 University of Sydney
RP Chen, JZ; Vitetta, L (通讯作者)，Medlab Clin, Sydney, NSW, Australia.
EM luis_vitetta@medlab.co
RI Vitetta, Luis/F-4206-2010; Salehi-Abargouei, Amin/C-9039-2011
OI Vitetta, Luis/0000-0002-7490-9298; Salehi-Abargouei,
   Amin/0000-0002-7580-6717; Chen, Jiezhong/0000-0003-1977-6143
CR Ackermann M, 2020, NEW ENGL J MED, V383, P120, DOI 10.1056/NEJMoa2015432
   Adam Y, 2013, J PSYCHOSOM RES, V74, P69, DOI 10.1016/j.jpsychores.2012.08.013
   Aguilar EC, 2016, J NUTR BIOCHEM, V34, P99, DOI 10.1016/j.jnutbio.2016.05.002
   Aktas B, 2020, TURK J BIOL, V44, P265, DOI 10.3906/biy-2005-102
   Anderson G, 2020, REV MED VIROL, V30, DOI 10.1002/rmv.2109
   Antunes KH, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-11152-6
   Archer DL, 2020, FRONT MED-LAUSANNE, V7, DOI 10.3389/fmed.2020.00292
   Arpaia N, 2013, NATURE, V504, P451, DOI 10.1038/nature12726
   Badawy AAB, 2019, INT J TRYPTOPHAN RES, V12, DOI 10.1177/1178646919868978
   Bansal M, 2020, DIABETES METAB SYND, V14, P247, DOI 10.1016/j.dsx.2020.03.013
   Batty GD, 2020, BRAIN BEHAV IMMUN, V89, P569, DOI 10.1016/j.bbi.2020.06.021
   Blanco-Melo D, 2020, CELL, V181, P1036, DOI 10.1016/j.cell.2020.04.026
   Bonetti PO, 2003, ARTERIOSCL THROM VAS, V23, P168, DOI 10.1161/01.ATV.0000051384.43104.FC
   Brandl K, 2017, CURR OPIN GASTROEN, V33, P128, DOI 10.1097/MOG.0000000000000349
   Budden KF, 2017, NAT REV MICROBIOL, V15, P55, DOI 10.1038/nrmicro.2016.142
   Buonaguro FM, 2020, REV MED VIROL, V30, DOI 10.1002/rmv.2134
   Burrell LM, 2005, EUR HEART J, V26, P369, DOI 10.1093/eurheartj/ehi114
   Campbell C, 2020, NATURE, V581, P475, DOI 10.1038/s41586-020-2193-0
   Chang PV, 2014, P NATL ACAD SCI USA, V111, P2247, DOI 10.1073/pnas.1322269111
   Chee YJ, 2020, J DIABETES INVEST, V11, P1104, DOI 10.1111/jdi.13326
   Chen JZ, 2020, IMMUNE NETW, V20
   Chen JZ, 2019, NUTRIENTS, V11, DOI 10.3390/nu11051026
   Chen JZ, 2019, J CELL BIOCHEM, V120, P2713, DOI 10.1002/jcb.27635
   Chen L, 2020, CARDIOVASC RES, V116, P1097, DOI 10.1093/cvr/cvaa078
   Chen NS, 2020, LANCET, V395, P507, DOI 10.1016/S0140-6736(20)30211-7
   CHEN VL, 2020, DIGEST DIS SCI 0927
   Churov AV, 2020, IMMUNOL LETT, V226, P83, DOI 10.1016/j.imlet.2020.07.004
   Cipolletta D, 2012, NATURE, V486, P549, DOI 10.1038/nature11132
   Codo AC, 2020, CELL METAB, V32, P437, DOI 10.1016/j.cmet.2020.07.007
   COHEN S, 1991, NEW ENGL J MED, V325, P606, DOI 10.1056/NEJM199108293250903
   Conlon MA, 2015, NUTRIENTS, V7, P17, DOI 10.3390/nu7010017
   Conte L, 2020, THER ADV RESPIR DIS, V14, DOI 10.1177/1753466620937170
   Costa FF, 2020, DIABETES METAB SYND, V14, P809, DOI 10.1016/j.dsx.2020.06.016
   Crouse Andrew, 2020, medRxiv, DOI 10.1101/2020.07.29.20164020
   Daniel C, 2008, J PHARMACOL EXP THER, V324, P23, DOI 10.1124/jpet.107.127209
   Dickson I, 2020, NAT REV GASTRO HEPAT, V17, P383, DOI 10.1038/s41575-020-0317-5
   Dinan TG, 2016, GENOME MED, V8, DOI 10.1186/s13073-016-0292-1
   Do JY, 2021, DIABETES METAB, V47, DOI 10.1016/j.diabet.2020.10.006
   Dosoky NS, 2020, APPL MICROBIOL BIOT, V104, P7657, DOI 10.1007/s00253-020-10771-0
   Du YZ, 2020, AM J RESP CRIT CARE, V201, P1372, DOI 10.1164/rccm.202003-0543OC
   Fachi JL, 2019, CELL REP, V27, P750, DOI 10.1016/j.celrep.2019.03.054
   Ferrario CM, 2005, CIRCULATION, V111, P2605, DOI 10.1161/CIRCULATIONAHA.104.510461
   Feuerer M, 2009, NAT MED, V15, P930, DOI 10.1038/nm.2002
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Foster, 2020, CLIN GASTROENTEROL H, VS1542-3565, P31371, DOI DOI 10.1016/J.CGH.2020.09.041
   Franceschi C, 2018, NAT REV ENDOCRINOL, V14, P576, DOI 10.1038/s41574-018-0059-4
   Franco R, 2020, J IMMUNOL, V205, P1198, DOI 10.4049/jimmunol.2000642
   Ganesan K, 2018, INT J MOL SCI, V19
   Gao YC, 2020, CTS-CLIN TRANSL SCI, V13, P1055, DOI 10.1111/cts.12897
   Goulter AB, 2004, BMC MED, V2, DOI 10.1186/1741-7015-2-19
   Goyal P, 2020, NEW ENGL J MED, V382, P2372, DOI 10.1056/NEJMc2010419
   Gu SX, 2021, NAT REV CARDIOL, V18, P194, DOI 10.1038/s41569-020-00469-1
   Gu SL, 2020, CLIN INFECT DIS, V71, P2669, DOI 10.1093/cid/ciaa709
   Guan W, 2020, NEW ENGL J MED, V382, P1708, DOI [10.1056/NEJMoa2002032, 10.1056/NEJMc2005203]
   Guarisco G, 2021, EAT WEIGHT DISORD-ST, V26, P1283, DOI 10.1007/s40519-020-00958-9
   Guo C, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-17834-w
   Guo L, 2020, CLIN INFECT DIS, V71, P778, DOI 10.1093/cid/ciaa310
   Gupta A, 2020, NAT MED, V26, P1017, DOI 10.1038/s41591-020-0968-3
   Hang SY, 2019, NATURE, V576, P143, DOI 10.1038/s41586-019-1785-z
   Haroon E, 2020, NEUROPSYCHOPHARMACOL, V45, P998, DOI 10.1038/s41386-020-0607-1
   He LH, 2020, FRONT MICROBIOL, V11, DOI 10.3389/fmicb.2020.01388
   Hill MA, 2020, METABOLISM, V107, DOI 10.1016/j.metabol.2020.154217
   Hoel H, 2021, J INTERN MED, V289, P523, DOI 10.1111/joim.13178
   Illiano P, 2020, FEBS J, V287, P833, DOI 10.1111/febs.15217
   Jiao WJ, 2020, AM J TRANSPLANT, V20, P2413, DOI 10.1111/ajt.15880
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Khailany RA, 2020, GENE REP, V19, DOI 10.1016/j.genrep.2020.100682
   Khoruts A, 2016, NAT REV GASTRO HEPAT, V13, DOI 10.1038/nrgastro.2016.98
   Kim S, 2018, CLIN SCI, V132, P701, DOI [10.1042/CS20180087, 10.1042/cs20180087]
   Kullar R, 2020, J CLIN GASTROENTEROL, V54, P841, DOI 10.1097/MCG.0000000000001432
   Kwok S, 2020, CLIN OBES, V10, DOI 10.1111/cob.12403
   Lamers MM, 2020, SCIENCE, V369, P50, DOI 10.1126/science.abc1669
   Lee JR, 2019, TRANSPL INFECT DIS, V21, DOI 10.1111/tid.13180
   Leisman DE, 2020, LANCET RESP MED, V8, P1233, DOI 10.1016/S2213-2600(20)30404-5
   Liao MF, 2020, NAT MED, V26, P842, DOI 10.1038/s41591-020-0901-9
   Lin L, 2020, GUT, V69, P997, DOI 10.1136/gutjnl-2020-321013
   Lippi G, 2021, EUR J GASTROEN HEPAT, V33, P114, DOI 10.1097/MEG.0000000000001742
   Liu PT, 2006, SCIENCE, V311, P1770, DOI 10.1126/science.1123933
   Lu RJ, 2020, LANCET, V395, P565, DOI 10.1016/S0140-6736(20)30251-8
   Luo P, 2020, AM J TROP MED HYG, V103, P69, DOI 10.4269/ajtmh.20-0375
   Lynch JP, 2018, J EXP MED, V215, P537, DOI 10.1084/jem.20170298
   Mahmudpour M, 2020, CYTOKINE, V133, DOI 10.1016/j.cyto.2020.155151
   Mandaliya DK, 2019, PANCREATOLOGY, V19, P280, DOI 10.1016/j.pan.2019.01.021
   Maniar K, 2018, BIOMED PHARMACOTHER, V107, P495, DOI 10.1016/j.biopha.2018.08.021
   Mardinoglu A, 2016, CELL METAB, V23, P10, DOI 10.1016/j.cmet.2015.12.012
   McHugh J, 2020, NAT REV RHEUMATOL, V16, P128, DOI 10.1038/s41584-020-0387-3
   McNelis JC, 2014, IMMUNITY, V41, P36, DOI 10.1016/j.immuni.2014.05.010
   Monteil V, 2020, CELL, V181, P905, DOI 10.1016/j.cell.2020.04.004
   MURCHU EO, 2020, REV MED VIROL 0923
   Ng SC, 2020, GUT, V69, P973, DOI 10.1136/gutjnl-2020-321195
   Nishimura S, 2009, NAT MED, V15, P914, DOI 10.1038/nm.1964
   Onder G, 2020, JAMA-J AM MED ASSOC, V323, P1775, DOI 10.1001/jama.2020.4683
   Palacios T, 2020, NUTRIENTS, V12, DOI 10.3390/nu12072041
   Panagiotou G, 2020, CLIN ENDOCRINOL, V93, P508, DOI 10.1111/cen.14276
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Muralitharan RR, 2021, J HUM HYPERTENS, V35, P162, DOI 10.1038/s41371-020-0388-3
   Robles-Vera I, 2020, AM J HYPERTENS, V33, P890, DOI 10.1093/ajh/hpaa103
   Robles-Vera I, 2020, FRONT PHYSIOL, V11, DOI 10.3389/fphys.2020.00277
   Roshan N, 2020, INFECT DIS THER, V9, P935, DOI 10.1007/s40121-020-00339-w
   Rubin TA, 2013, ANAEROBE, V19, P22, DOI 10.1016/j.anaerobe.2012.11.004
   Ruff WE, 2020, NAT REV MICROBIOL, V18, P521, DOI 10.1038/s41579-020-0367-2
   Scheen AJ, 2020, DIABETES METAB, V46, P423, DOI 10.1016/j.diabet.2020.07.006
   Schmitt V, 2013, EXP GERONTOL, V48, P1379, DOI 10.1016/j.exger.2013.09.003
   Shintouo CM, 2020, EXP GERONTOL, V141, DOI 10.1016/j.exger.2020.111079
   Singh S, 2020, GASTROENTEROLOGY, V159, P768, DOI 10.1053/j.gastro.2020.04.064
   Song XY, 2020, NATURE, V577, P410, DOI 10.1038/s41586-019-1865-0
   Subramanian S, 2020, VACCINES-BASEL, V8, DOI 10.3390/vaccines8020320
   Sulaiman T, 2020, JGH OPEN, V4, P1162, DOI 10.1002/jgh3.12415
   Tai WB, 2020, CELL MOL IMMUNOL, V17, P613, DOI 10.1038/s41423-020-0400-4
   Thevarajan I, 2020, NAT MED, V26, P453, DOI 10.1038/s41591-020-0819-2
   Thomas T, 2020, JCI INSIGHT, V5, DOI 10.1172/jci.insight.140327
   Troseid M, 2020, EBIOMEDICINE, V52, DOI 10.1016/j.ebiom.2020.102649
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Vaidya A, 2012, METABOLISM, V61, P450, DOI 10.1016/j.metabol.2011.09.007
   Vallianou N, 2019, CURR OBES REP, V8, P317, DOI 10.1007/s13679-019-00352-2
   Vanuytsel T, 2014, GUT, V63, P1293, DOI 10.1136/gutjnl-2013-305690
   Varga Z, 2020, LANCET, V395, P1417, DOI 10.1016/S0140-6736(20)30937-5
   Verdecchia P, 2020, EUR J INTERN MED, V76, P14, DOI 10.1016/j.ejim.2020.04.037
   Verity R., 2020, LANCET INFECT DIS, V20, P669, DOI DOI 10.1016/S1473-3099(20)30243-7
   Verma N, 2021, GASTROENTEROLOGY, V160, P1893, DOI 10.1053/j.gastro.2020.05.090
   Wang DW, 2020, J COASTAL RES, P1, DOI 10.2112/JCR-SI109-001.1
   Wang G, 2020, FOOD FUNCT, V11, P5898, DOI [10.1039/c9fo02761k, 10.1039/C9FO02761K]
   WANG J, 2020, FRONT MICROBIOL, V11
   Wang J, 2016, NAT GENET, V48, P1396, DOI 10.1038/ng.3695
   Wong MCS, 2020, J INFECTION, V81, pE31, DOI 10.1016/j.jinf.2020.06.012
   Woodruff M, 2020, MEDRXIV, DOI 10.1101/2020.04.29.20083717
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Wu JT, 2020, LANCET, V395, P689, DOI 10.1016/S0140-6736(20)30260-9
   Wypych TP, 2019, NAT IMMUNOL, V20, P1279, DOI 10.1038/s41590-019-0451-9
   Yang T, 2020, HYPERTENSION, V76, pE1, DOI 10.1161/HYPERTENSIONAHA.120.15360
   Yao HP, 2020, CELL, V183, P730, DOI 10.1016/j.cell.2020.09.018
   Ye K, 2021, J AM COLL NUTR, V40, P724, DOI 10.1080/07315724.2020.1826005
   Yoo KM, 2020, J GASTROEN HEPATOL, V35, P2088, DOI 10.1111/jgh.15082
   Young BE, 2020, JAMA-J AM MED ASSOC, V323, P1488, DOI 10.1001/jama.2020.3204
   Zhang DP, 2020, FRONT MICROBIOL, V11, DOI 10.3389/fmicb.2020.00301
   Zhang N, 2020, BRAIN BEHAV, V10, DOI 10.1002/brb3.1699
   Zheng ZH, 2020, J INFECTION, V81, pE16, DOI 10.1016/j.jinf.2020.04.021
   Zhou J, 2020, NAT MED, V26, P1077, DOI 10.1038/s41591-020-0912-6
   Zhou P, 2020, NATURE, V588, pE6, DOI 10.1038/s41586-020-2951-z
   Zhou YJ, 2020, LIVER INT, V40, P2160, DOI 10.1111/liv.14575
   Zhu Y, 2020, INT J MOL MED, V46, P936, DOI 10.3892/ijmm.2020.4674
   Zuo T, 2020, GASTROENTEROLOGY, V159, P944, DOI 10.1053/j.gastro.2020.05.048
NR 142
TC 29
Z9 29
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1052-9276
EI 1099-1654
J9 REV MED VIROL
JI Rev. Med. Virol.
PD SEP
PY 2021
VL 31
IS 5
AR e2211
DI 10.1002/rmv.2211
EA JAN 2021
PG 13
WC Virology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Virology
GA US5IB
UT WOS:000607251500001
PM 34546607
OA Green Published
DA 2023-06-08
ER

PT J
AU Hannachi, N
   Camoin-Jau, L
AF Hannachi, Nadji
   Camoin-Jau, Laurence
TI Drug Response Diversity: A Hidden Bacterium?
SO JOURNAL OF PERSONALIZED MEDICINE
LA English
DT Review
DE pharmacomicrobiomics; drug response; bacteria; intestinal microbiota
ID PROTON PUMP INHIBITORS; FECAL MICROBIOTA TRANSPLANTATION; GUT
   MICROBIOTA; WHIPPLES-DISEASE; AKKERMANSIA-MUCINIPHILA;
   RHEUMATOID-ARTHRITIS; TROPHERYMA-WHIPPLEI; EFFICACY; METFORMIN; TOXICITY
AB Interindividual heterogeneity in response to treatment is a real public health problem. It is a factor that can be responsible not only for ineffectiveness or fatal toxicity but also for hospitalization due to iatrogenic effects, thus increasing the cost of patient care. Several research teams have been interested in what may be at the origin of these phenomena, particularly at the genetic level and the basal activity of organs dedicated to the inactivation and elimination of drug molecules. Today, a new branch is being set up, explaining the enigmatic part that could not be explained before. Pharmacomicrobiomics attempts to investigate the interactions between bacteria, especially those in the gut, and drug response. In this review, we provide a state of the art on what this field has brought as new information and discuss the challenges that lie ahead to see the real application in clinical practice.
C1 [Hannachi, Nadji; Camoin-Jau, Laurence] Aix Marseille Univ, IRD, APHM, MEPHI,IHU Mediterranee Infect, 19-21 Blvd Jean Moulin, F-13005 Marseille, France.
   [Hannachi, Nadji] Univ Ferhat Abbas Setif I, Fac Med, Dept Pharm, Setif 19000, Algeria.
   [Camoin-Jau, Laurence] Hop La Timone, APHM, Lab Hematol, Blvd Jean Moulin, F-13005 Marseille, France.
C3 Institut de Recherche pour le Developpement (IRD); UDICE-French Research
   Universities; Aix-Marseille Universite; Assistance Publique-Hopitaux de
   Marseille; Universite Ferhat Abbas Setif; UDICE-French Research
   Universities; Aix-Marseille Universite; Assistance Publique-Hopitaux de
   Marseille
RP Camoin-Jau, L (通讯作者)，Aix Marseille Univ, IRD, APHM, MEPHI,IHU Mediterranee Infect, 19-21 Blvd Jean Moulin, F-13005 Marseille, France.; Camoin-Jau, L (通讯作者)，Hop La Timone, APHM, Lab Hematol, Blvd Jean Moulin, F-13005 Marseille, France.
EM n_adji07@live.fr; laurence.camoin@ap-hm.fr
RI Hannachi, Nadji/GYV-3658-2022
FU Institut Hospitalo-Universitaire (IHU) Mediterannee Infection, Marseille
FX This work was supported by the Institut Hospitalo-Universitaire (IHU)
   Mediterannee Infection, Marseille.
CR Alexander JL, 2017, NAT REV GASTRO HEPAT, V14, P356, DOI 10.1038/nrgastro.2017.20
   Angelis-Stoforidis P, 1999, CLIN EXP RHEUMATOL, V17, P313
   BIRKETT DJ, 1997, AUST PRESCR, V20, P9
   Blackler RW, 2015, BRIT J PHARMACOL, V172, P992, DOI 10.1111/bph.12961
   Boelsterli UA, 2013, TOXICOL SCI, V131, P654, DOI 10.1093/toxsci/kfs310
   Bruno G, 2019, WORLD J GASTROENTERO, V25, P2706, DOI 10.3748/wjg.v25.i22.2706
   Bures J, 2013, GASTROENT RES PRACT, V2013, DOI 10.1155/2013/478349
   Camci G, 2016, J CLIN NEUROL, V12, P147, DOI 10.3988/jcn.2016.12.2.147
   Chang CW, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21020386
   Cheng KW, 2019, PHARMACOL RES, V139, P41, DOI 10.1016/j.phrs.2018.10.029
   Conlon MA, 2015, NUTRIENTS, V7, P17, DOI 10.3390/nu7010017
   Costello SP, 2017, ALIMENT PHARM THER, V46, P213, DOI 10.1111/apt.14173
   Daillere R, 2016, IMMUNITY, V45, P931, DOI 10.1016/j.immuni.2016.09.009
   Dashnyam P, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-34678-z
   Davis JA, 2020, OBES RES CLIN PRACT, V14, P524, DOI 10.1016/j.orcp.2020.10.006
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Dervieux T, 2004, ARTHRITIS RHEUM-US, V50, P2766, DOI 10.1002/art.20460
   Dial S, 2004, CAN MED ASSOC J, V171, P33, DOI 10.1503/cmaj.1040876
   Diasio RB, 1998, BRIT J CLIN PHARMACO, V46, P1, DOI 10.1046/j.1365-2125.1998.00050.x
   DOBKIN JF, 1983, SCIENCE, V220, P325
   Doestzada M, 2018, PROTEIN CELL, V9, P432, DOI 10.1007/s13238-018-0547-2
   DUNN CJ, 1995, DRUGS, V49, P721, DOI 10.2165/00003495-199549050-00007
   Erdman SE, 2017, FREE RADICAL BIO MED, V105, P28, DOI 10.1016/j.freeradbiomed.2016.11.013
   Ervin SM, 2019, ACS CHEM BIOL, V14, P2737, DOI 10.1021/acschembio.9b00663
   Falony G, 2016, SCIENCE, V352, P560, DOI 10.1126/science.aad3503
   Feng WW, 2020, THERANOSTICS, V10, P11278, DOI 10.7150/thno.47289
   Fenollar F, 2014, J INFECTION, V69, P103, DOI 10.1016/j.jinf.2014.05.008
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Freedberg DE, 2014, CLIN LAB MED, V34, P771, DOI 10.1016/j.cll.2014.08.008
   Fuller AT, 1937, LANCET, V1, P194
   Geller LT, 2017, SCIENCE, V357, P1156, DOI 10.1126/science.aah5043
   Glaser C, 2017, ORPHANET J RARE DIS, V12, DOI 10.1186/s13023-017-0630-4
   Glossmann HH, 2019, EUR J PHARMACOL, V865, DOI 10.1016/j.ejphar.2019.172782
   Goodman SM, 2015, CLIN EXP RHEUMATOL, V33, P272
   Gopalakrishnan V, 2018, SCIENCE, V359, P97, DOI 10.1126/science.aan4236
   Haiser HJ, 2014, GUT MICROBES, V5, P233, DOI 10.4161/gmic.27915
   Haiser HJ, 2013, SCIENCE, V341, P295, DOI 10.1126/science.1235872
   Halilova KI, 2012, INT J RHEUMATOL, V2012, DOI 10.1155/2012/978396
   Harsch Igor Alexander, 2018, Med Sci (Basel), V6, DOI 10.3390/medsci6020032
   Hashim H, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0112330
   Higuchi K, 2009, J GASTROENTEROL, V44, P879, DOI 10.1007/s00535-009-0102-2
   Iida N, 2013, SCIENCE, V342, P967, DOI 10.1126/science.1240527
   Imhann F, 2016, GUT, V65, P740, DOI 10.1136/gutjnl-2015-310376
   Juul FE, 2018, NEW ENGL J MED, V378, P2535, DOI 10.1056/NEJMc1803103
   Kalow W, 1998, PHARMACOGENETICS, V8, P283
   Kalow W, 2005, METH MOL B, V311, P3
   Kim CH, 2018, CELL MOL IMMUNOL, V15, P88, DOI 10.1038/cmi.2017.57
   Kim DH, 2015, DRUG METAB DISPOS, V43, P1581, DOI 10.1124/dmd.115.063867
   Kneitz C, 2005, SCAND J RHEUMATOL, V34, P148, DOI 10.1080/03009740510015230
   Kodawara T, 2016, BASIC CLIN PHARMACOL, V118, P333, DOI 10.1111/bcpt.12511
   Kong R, 2014, CLIN CANCER RES, V20, P3521, DOI 10.1158/1078-0432.CCR-14-0395
   Koppel N, 2018, ELIFE, V7, DOI [10.7554/eLife.33953, 10.7554/elife.33953]
   Kumar K, 2018, J CELL BIOCHEM, V119, P5287, DOI 10.1002/jcb.26638
   Lahner E, 2009, ALIMENT PHARM THER, V29, P379, DOI 10.1111/j.1365-2036.2008.03906.x
   Lazar V, 2018, FRONT IMMUNOL, V9, DOI 10.3389/fimmu.2018.01830
   Lehouritis P, 2015, SCI REP-UK, V5, DOI 10.1038/srep14554
   Lepidi H, 2004, J INFECT DIS, V190, P935, DOI 10.1086/422845
   Li YT, 2016, ALIMENT PHARM THER, V43, P445, DOI 10.1111/apt.13492
   MacLeod-Glover N, 2016, CAN FAM PHYSICIAN, V62, P223
   Marshall A, 1997, NAT BIOTECHNOL, V15, P1249, DOI 10.1038/nbt1197-1249
   Marth T, 2015, ALIMENT PHARM THER, V41, P709, DOI 10.1111/apt.13140
   Marth T, 2014, WORLD J CARDIOL, V6, P1278, DOI 10.4330/wjc.v6.i12.1278
   Matson V, 2018, SCIENCE, V359, P104, DOI 10.1126/science.aao3290
   Rodriguez JM, 2015, MICROB ECOL HEALTH D, V26, DOI 10.3402/mehd.v26.26050
   Nakamura H., 1994, J TOXICOL SCI, V19, P89
   Nakayama H, 1997, PHARMACOGENETICS, V7, P35, DOI 10.1097/00008571-199702000-00005
   Niehues M, 2009, J PHARM PHARMACOL, V61, P1303, DOI 10.1211/jpp/61.10.0005
   Paramsothy S, 2017, LANCET, V389, P1218, DOI 10.1016/S0140-6736(17)30182-4
   PEPPERCORN MA, 1972, J PHARMACOL EXP THER, V181, P555
   Pirmohamed M, 2006, BRIT J CLIN PHARMACO, V62, P509, DOI 10.1111/j.1365-2125.2006.02806.x
   Pouncey AL, 2018, ECANCERMEDICALSCIENC, V12, DOI 10.3332/ecancer.2018.868
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Ramos Jose M, 2015, J Med Case Rep, V9, P165, DOI 10.1186/s13256-015-0632-6
   Ramos-Romero S, 2018, AM J PHYSIOL-ENDOC M, V314, pE552, DOI 10.1152/ajpendo.00323.2017
   Rizkallah Mariam Reyad, 2010, Current Pharmacogenomics & Personalized Medicine, V8, P182
   Routy B, 2018, SCIENCE, V359, P91, DOI 10.1126/science.aan3706
   Sayers E, 2018, AIMS MICROBIOL, V4, P642, DOI 10.3934/microbiol.2018.4.642
   Scher JU, 2020, NAT REV RHEUMATOL, V16, P282, DOI 10.1038/s41584-020-0395-3
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Sivan A, 2015, SCIENCE, V350, P1084, DOI 10.1126/science.aac4255
   Stein Alexander, 2010, Ther Adv Med Oncol, V2, P51, DOI 10.1177/1758834009355164
   Sun CN, 2019, SAUDI PHARM J, V27, P1146, DOI 10.1016/j.jsps.2019.09.011
   TANGE SH, 1994, J CLIN PHARMACOL, V34, P200, DOI 10.1002/j.1552-4604.1994.tb03987.x
   Tilg H, 2014, GUT, V63, P1513, DOI 10.1136/gutjnl-2014-306928
   Ugarte-Torres A, 2018, CLIN INFECT DIS, V67, P221, DOI 10.1093/cid/ciy057
   Vetizou M, 2015, SCIENCE, V350, P1079, DOI 10.1126/science.aad1329
   Viaud S, 2013, SCIENCE, V342, P971, DOI 10.1126/science.1240537
   Wallace JL, 2011, GASTROENTEROLOGY, V141, P1314, DOI 10.1053/j.gastro.2011.06.075
   Wang L, 2020, PHARMACOL RES, V159, DOI 10.1016/j.phrs.2020.104979
   Wang YH, 2018, NAT MED, V24, P1804, DOI 10.1038/s41591-018-0238-9
   Wilkinson EM, 2018, MATURITAS, V112, P53, DOI 10.1016/j.maturitas.2018.03.012
   Wise ES, 2015, J ORTHOP, V12, pS145, DOI 10.1016/j.jor.2015.10.023
   Wright B, 2013, CARDIOVASC RES, V97, P13, DOI 10.1093/cvr/cvs304
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Wu HJ, 2012, GUT MICROBES, V3, P4, DOI 10.4161/gmic.19320
   Xue L, 2017, BRIT J CLIN PHARMACO, V83, P823, DOI 10.1111/bcp.13157
   Yang B, 2018, TRENDS FOOD SCI TECH, V79, P116, DOI 10.1016/j.tifs.2018.07.006
   Yauw STK, 2018, SURG INFECT, V19, P417, DOI 10.1089/sur.2017.245
   Zhang X, 2015, NAT MED, V21, P895, DOI 10.1038/nm.3914
   Zhou BL, 2018, EBIOMEDICINE, V33, P122, DOI 10.1016/j.ebiom.2018.06.029
NR 100
TC 1
Z9 1
U1 0
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2075-4426
J9 J PERS MED
JI J. Pers. Med.
PD MAY
PY 2021
VL 11
IS 5
AR 345
DI 10.3390/jpm11050345
PG 16
WC Health Care Sciences & Services; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services; General & Internal Medicine
GA SH4QI
UT WOS:000654121400001
PM 33922920
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Fagbohun, OF
   Awoniran, PO
   Babalola, OO
   Agboola, FK
   Msagati, TAM
AF Fagbohun, Oladapo F.
   Awoniran, Paul O.
   Babalola, Olubunmi O.
   Agboola, Femi K.
   Msagati, Titus A. M.
TI Changes in the biochemical, hematological and histopathological
   parameters in STZ-Induced diabetic rats and the ameliorative effect of
   Kigelia africana fruit extract
SO HELIYON
LA English
DT Article
DE Diabetes mellitus; Kigelia africana; Streptozotocin; FTIR;
   Hyperglycemia; Metformin; Chemistry; Food science; Agricultural science;
   Biological sciences; Health sciences
ID INSULIN-SECRETION; NITRIC-OXIDE; STEM BARK; STREPTOZOTOCIN; NEPHROPATHY;
   PODOCYTES; CELLS
AB Background: Biochemical, hematological and histological changes are major observable clinical and pathological factors associated with Diabetes mellitus. Derangement in the levels of these parameters increases the risk of the development of complications. In another hand, gastrointestinal intolerance due to the development of lactic acidosis on the gastrointestinal tract and the intestinal microbiome is the toxic side effect of various synthetic antidiabetic agents. The use of Kigelia africana fruit extract for the treatment of diabetes has been scientifically validated. This study therefore aimed at investigating changes in the biochemical, hematological and histological parameters as well as the determination of the functional groups present in the hexane fraction of the fruit.
   Methods: The fruits were extracted with ethanol and partitioned with n-hexane to obtain the hexane fraction. Diabetic rats induced with streptozotocin (STZ) were divided into 5 groups of 5 animals each and treated with 100, 200 and 400 mg/kg body weight (BW) hexane fraction alongside reference standard; glibenclamide. Fasting blood glucose levels and their body weights were monitored weekly. Animals were sacrificed at the end of 28-day treatment. Blood, liver, and kidney were collected for biochemical, hematological and histopathological analyses. Fourier transform infrared resonance (FTIR) spectroscopic analysis was carried out on the hexane fraction for functional group determination.
   Results: The hexane fraction of K. africana fruit extract decreased fasting blood glucose (FBG) levels significantly with ameliorative effects on the hematological parameters such as packed cell volume (PCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), and red blood cells (RBC) etc. There were significant regenerative differences in the biochemical activities as well as the renal cortex and midzone sections of the rat's kidney and liver when compared with untreated diabetic rats. The presence of polyphenolic functional groups via FTIR analysis suggested high antioxidant activities of the fruit extract.
   Conclusion: The use of Kigelia africana fruit extracts protects against biochemical, hematological and histological changes that are injurious to diabetic patients. Therefore, Kigelia africana fruit is a good hepatic- and nephroprotective agent and has a hemato-protective ability.
C1 [Fagbohun, Oladapo F.] First Tech Univ, Dept Biomed Engn, Ibadan, Oyo State, Nigeria.
   [Awoniran, Paul O.] Obafemi Awolowo Univ, Dept Anat & Cell Biol, Ife, Osun State, Nigeria.
   [Babalola, Olubunmi O.; Agboola, Femi K.] Obafemi Awolowo Univ, Dept Biochem & Mol Biol, Ife, Osun State, Nigeria.
   [Msagati, Titus A. M.] Univ South Africa UNISA, Coll Sci Engn & Technol, Nanotechnol & Water Sustainabil Res Unit, Florida Pk, Johannesburg, South Africa.
C3 Obafemi Awolowo University; Obafemi Awolowo University; University of
   South Africa
RP Fagbohun, OF (通讯作者)，First Tech Univ, Dept Biomed Engn, Ibadan, Oyo State, Nigeria.
EM oladapo.fagbohun@tech-u.edu.ng
RI Fagbohun, Oladapo/AAU-4582-2020; Msagati, Titus/AAB-7670-2020
OI Fagbohun, Oladapo/0000-0002-1340-6697; Msagati,
   Titus/0000-0002-9621-5051; Awoniran, Paul/0000-0002-3903-2195
CR Ababio G.K., 2017, CLIN MED BIOCH, V3, P129
   Abrass C.K., 2005, W J MED, V162, P318
   ABRASS CK, 1988, DIABETES, V37, P1695, DOI 10.2337/diabetes.37.12.1695
   Akinmoladun A.C., 2014, ANTIDIABETIC BOT THE, DOI [10.5772/57339, DOI 10.5772/57339, 10.5772/57339.]
   Alsaad KO, 2007, J CLIN PATHOL, V60, P18, DOI 10.1136/jcp.2005.035592
   [Anonymous], 2016, TANTA MED J, DOI [DOI 10.4103/1110-1415.201723, 10.4103/1110-1415.201723]
   Atawodi S. E. O., 2015, Annual Research & Review in Biology, V5, P1, DOI 10.9734/ARRB/2015/8632
   Atolani O, 2011, EXCLI J, V10, P264
   Azu OO, 2010, MIDDLE EAST FERTIL S, V15, P200, DOI 10.1016/j.mefs.2010.07.001
   BOSCO D, 1989, EXP CELL RES, V184, P72, DOI 10.1016/0014-4827(89)90365-0
   Chawla R, 1999, PRACTICAL CLIN BIOCH, P106
   Chen H, 2006, AM J PHYSIOL-HEART C, V290, pH137, DOI 10.1152/ajpheart.00768.2005
   Chikezie P, 2015, INT J BIOL CHEM, V9, P92, DOI DOI 10.3923/IJBC.2015.92.109
   Claudino M, 2007, PLOS ONE, V2, DOI 10.1371/journal.pone.0001320
   Daniel L., 2013, CANC CHEMOTHER, V2, P18
   Dhanya K. G., 2017, INT J BIOTECHNOLOGY, V13, P351
   Fagbohun OF, 2020, BIOL TRACE ELEM RES, V195, P679, DOI 10.1007/s12011-019-01869-2
   Fisher EB, 2007, DIABETES EDUCATOR, V33, P1080, DOI 10.1177/0145721707309808
   Francisco J.B., 2012, ISLETS, V4, P108
   HALBAN PA, 1987, DIABETES, V36, P783, DOI 10.2337/diabetes.36.7.783
   Herman WH, 2015, DIABETES CARE, V38, P1449, DOI 10.2337/dc14-2459
   Jain R, 2009, DIABETES OBES METAB, V11, P159, DOI 10.1111/j.1463-1326.2009.01102.x
   Jargin SV, 2018, J INTERCULT ETHNOPHA, V7, P97, DOI 10.5455/jice.20171015041941
   Jelodar G A, 2005, Indian J Med Sci, V59, P64
   Kalayci D., 2017, GAZI MED J, V29, P2147
   Kalluri R, 2006, J AM SOC NEPHROL, V17, P2383, DOI 10.1681/ASN.2006060628
   Kannan A., 2011, ASIAN J PHARM CLIN R, V4, P1
   Kierszenbaum A., 2012, HISTOLOGY CELL BIOLO, P23
   Kishore L., 2018, J AYURVEDA INTEGR ME
   Klover PJ, 2004, INT J BIOCHEM CELL B, V36, P753, DOI 10.1016/j.biocel.2003.10.002
   Kuroe M, 2007, ACTA THERIOL, V52, P355, DOI 10.1007/BF03194233
   Loeffler I, 2011, J AM SOC NEPHROL, V22, P649, DOI 10.1681/ASN.2010010098
   Loghmani Emily S, 2005, Curr Diab Rep, V5, P385, DOI 10.1007/s11892-005-0098-9
   LORKE D, 1983, ARCH TOXICOL, V54, P275, DOI 10.1007/BF01234480
   Lote CJ, 2000, PRINCIPLES RENAL PHY, P34
   Ludidi A, 2019, BIOMED PHARMACOTHER, V116, DOI 10.1016/j.biopha.2019.108925
   Maezawa Y, 2015, J DIABETES INVEST, V6, P3, DOI 10.1111/jdi.12255
   Martins I, 2011, AGING-US, V3, P821, DOI 10.18632/aging.100380
   Mbaka G.O., 2010, J ADV MED MED RES, V21, P621
   MENE P, 1989, PHYSIOL REV, V69, P1347, DOI 10.1152/physrev.1989.69.4.1347
   Mitali Das, 2013, International Journal of Green Pharmacy, V7, P274
   Nakamura T, 2000, NEPHROL DIAL TRANSPL, V15, P1379, DOI 10.1093/ndt/15.9.1379
   Okine A, 2005, ANIM FEED SCI TECH, V121, P329, DOI 10.1016/j.anifeedsci.2005.02.032
   Oyedemi S. O., 2011, Asian Pacific Journal of Tropical Biomedicine, V1, P353, DOI 10.1016/S2221-1691(11)60079-8
   Patras A, 2010, TRENDS FOOD SCI TECH, V21, P3, DOI 10.1016/j.tifs.2009.07.004
   Perez-Trueba G, 2003, REDOX REP, V8, P215, DOI 10.1179/135100003225002718
   Petlevski Roberta, 2006, Acta Pharmaceutica (Zagreb), V56, P87
   Pitocco D, 2013, INT J MOL SCI, V14, P21525, DOI 10.3390/ijms141121525
   PORTHA B, 1974, DIABETES, V23, P889, DOI 10.2337/diab.23.11.889
   POWERS AC, 2011, GOODMAN GILMANS PHAR, P1237
   Ramachandran Vadivelan, 2011, Advances in Applied Science Research, V2, P179
   Rashid U, 2019, J ETHNOPHARMACOL, V242, DOI 10.1016/j.jep.2019.112038
   REITMAN S, 1957, AM J CLIN PATHOL, V28, P56, DOI 10.1093/ajcp/28.1.56
   Rena G, 2017, DIABETOLOGIA, V60, P1577, DOI 10.1007/s00125-017-4342-z
   RiceEvans CA, 1997, TRENDS PLANT SCI, V2, P152, DOI 10.1016/S1360-1385(97)01018-2
   Rodriguez A, 2020, GEODERMA, V359, DOI 10.1016/j.geoderma.2019.113990
   Ross M.H., 2011, HISTOLOGY TEXT ATLAS, P35
   Sanlioglu AD, 2013, ISLETS, V5, P67, DOI 10.4161/isl.24590
   Schrier RW, 2004, J CLIN INVEST, V114, P5, DOI 10.1172/JC1200422353
   Shaw JE, 2010, DIABETES RES CLIN PR, V87, P4, DOI 10.1016/j.diabres.2009.10.007
   Sikarwar MS, 2010, J PHARM BIOALLIED SC, V2, P18, DOI 10.4103/0975-7406.62700
   Sinelli N, 2011, FOOD RES INT, V44, P1427, DOI 10.1016/j.foodres.2011.02.046
   Sodipo OA, 2012, J MED MED SCI, V3, P93
   Spinas GA, 1999, NEWS PHYSIOL SCI, V14, P49, DOI 10.1152/physiologyonline.1999.14.2.49
   STEFFES MW, 1989, DIABETES, V38, P1077, DOI 10.2337/diabetes.38.9.1077
   Stuart B., 2005, INFRARED SPECTROSCOP
   Susztak K, 2006, DIABETES, V55, P225, DOI 10.2337/diabetes.55.01.06.db05-0894
   Svobodova Alena, 2003, Biomedical Papers (Olomouc), V147, P137
   Thomas DD, 2008, FREE RADICAL BIO MED, V45, P18, DOI 10.1016/j.freeradbiomed.2008.03.020
   Thomas MC, 2003, DIABETES CARE, V26, P1164, DOI 10.2337/diacare.26.4.1164
   Tietz N.W., 1995, CLIN GUIDE LAB TESTS, P22
   Unwin N, 2010, DIABETES RES CLIN PR, V87, P2, DOI 10.1016/j.diabres.2009.11.006
   Vleming LJ, 1997, CLIN NEPHROL, V47, P158
   Wadkar K., 2008, J HERBAL MED TOXICOL, V2, P45
   WEATHERBURN MW, 1967, ANAL CHEM, V39, P971, DOI 10.1021/ac60252a045
   Wojtusciszyn A, 2008, DIABETOLOGIA, V51, P1843, DOI 10.1007/s00125-008-1103-z
   World Health Organisation, 2017, WHO MORT DAT
   Zheng SR, 2004, DIABETES, V53, P3248, DOI 10.2337/diabetes.53.12.3248
NR 78
TC 10
Z9 10
U1 0
U2 1
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
EI 2405-8440
J9 HELIYON
JI Heliyon
PD MAY
PY 2020
VL 6
IS 5
AR c03989
DI 10.1016/j.heliyon.2020.e03989
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA LU4TO
UT WOS:000537749900139
PM 32462092
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Wang, XL
   Wang, Z
   Liu, D
   Jiang, H
   Cai, C
   Li, GY
   Yu, GL
AF Wang, Xueliang
   Wang, Zhe
   Liu, Di
   Jiang, Hao
   Cai, Chao
   Li, Guoyun
   Yu, Guangli
TI Canagliflozin Prevents Lipid Accumulation, Mitochondrial Dysfunction,
   and Gut Microbiota Dysbiosis in Mice With Diabetic Cardiovascular
   Disease
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE canagliflozin; mitochondrion; hypolipidemic; colonic microbiota;
   myocardial protection; diabetic cardiovascular disease
ID LOW-GRADE INFLAMMATION; ENDOTHELIAL DYSFUNCTION; OXIDATIVE STRESS;
   SCIENTIFIC STATEMENT; INSULIN-RESISTANCE; METABOLIC SYNDROME; GLYCEMIC
   CONTROL; SOLUBLE CD40L; HIGH-FAT; TYPE-2
AB Type 2 diabetes mellitus (T2DM) is associated with cardiovascular disease (CVD) and sodium glucose cotransporter 2 inhibitors, as oral medications for T2DM treatment have shown the potential to improve vascular dysfunction. The aim of this study was to evaluate the ability of canagliflozin (Cana) to relieve CVD in T2DM mice and its possible action mechanism. Mice with diabetic CVD was conducted by a high-fat diet for 24 weeks, followed by oral gavaging with metformin (200 mg/kg/day) or Cana (50 mg/kg/day) for 6 weeks. The result demonstrated that Cana reduced serum lipid accumulation, and decreased the arteriosclerosis index and atherogenic index of plasma. In addition, Cana treatment reduced the circulating markers of inflammation. More importantly, Cana improved cardiac mitochondrial homeostasis and relieved oxidative stress. Moreover, Cana treatment alleviated the myocardial injury with decreasing levels of serous soluble cluster of differentiation 40 ligand and cardiac troponin I. Thus, cardiovascular abnormality was relieved by suppressing fibrosis and basement membrane thickening, while elevating the cluster of differentiation 31 expression level. Importantly, Cana increased the ratio of gut bacteria Firmicutes/Bacteroidetes and the relative abundance of Alistipes, Olsenella, and Alloprevotella, while it decreased the abundance of Mucispirillum, Helicobacter, and Proteobacteria at various taxonomic levels in mice with diabetic CVD. In short, Cana treatment altered the colonic microbiota composition close to the normal level, which was related with blood lipid, inflammation, and oxidative stress, and might play a vital role in CVD. In general, the improvements in the gut microbiota and myocardial mitochondrial homeostasis may represent the mechanism of Cana on CVD treatment.
C1 [Wang, Xueliang; Wang, Zhe; Liu, Di; Jiang, Hao; Cai, Chao; Li, Guoyun; Yu, Guangli] Ocean Univ China, Sch Med & Pharm, Shandong Prov Key Lab Glycosci & Glycotechnol, Key Lab Marine Drugs,Minist Educ, Qingdao, Peoples R China.
   [Wang, Xueliang] Sun Yat Sen Univ, Affiliated Hosp 1, Precis Med Inst, Guangzhou, Peoples R China.
   [Jiang, Hao; Cai, Chao; Li, Guoyun; Yu, Guangli] Pilot Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao, Peoples R China.
C3 Ocean University of China; Sun Yat Sen University; Laoshan Laboratory
RP Wang, XL; Jiang, H; Yu, GL (通讯作者)，Ocean Univ China, Sch Med & Pharm, Shandong Prov Key Lab Glycosci & Glycotechnol, Key Lab Marine Drugs,Minist Educ, Qingdao, Peoples R China.; Wang, XL (通讯作者)，Sun Yat Sen Univ, Affiliated Hosp 1, Precis Med Inst, Guangzhou, Peoples R China.; Jiang, H; Yu, GL (通讯作者)，Pilot Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao, Peoples R China.
EM haojiang@ouc.edu.cn; glyu@ouc.edu.cn
FU National Natural Science Foundation of China [81991522, 81402982,
   21807094]; National Science and Technology Major Project of China
   [2018ZX09735-004]; Shandong Provincial Major Science and Technology
   Innovation Project [2018SDKJ0404]; Taishan Scholar Climbing Project
   [TSPD20210304]; China Postdoctoral Science Foundation [2021M703684];
   Fundamental Research Funds for the Central Universities [202042005];
   Natural Science Foundation of Shandong Province [ZR2017BC007]
FX Funding This work was supported by the National Natural Science
   Foundation of China (81991522, 81402982, 21807094), National Science and
   Technology Major Project of China (2018ZX09735-004), Shandong Provincial
   Major Science and Technology Innovation Project (2018SDKJ0404), Taishan
   Scholar Climbing Project (TSPD20210304), Project funded by the China
   Postdoctoral Science Foundation (2021M703684), Fundamental Research
   Funds for the Central Universities (202042005), and Natural Science
   Foundation of Shandong Province (ZR2017BC007).
CR Amabebe E, 2020, FRONT IMMUNOL, V11, DOI 10.3389/fimmu.2020.02184
   Arjinajarn P, 2016, PHYTOMEDICINE, V23, P1753, DOI 10.1016/j.phymed.2016.10.014
   Aronson D, 2002, CARDIOVASC DIABETOL, V1, DOI 10.1186/1475-2840-1-1
   Battson ML, 2018, AM J PHYSIOL-ENDOC M, V314, pE468, DOI 10.1152/ajpendo.00187.2017
   BECKMANN R, 1969, DIABETOLOGIA, V5, P318, DOI 10.1007/BF00452906
   Boulange CL, 2016, GENOME MED, V8, DOI 10.1186/s13073-016-0303-2
   Braunwald E, 2008, NEW ENGL J MED, V358, P2148, DOI 10.1056/NEJMra0800239
   Brindle P, 2006, HEART, V92, P1752, DOI 10.1136/hrt.2006.087932
   Carr MC, 2004, J CLIN ENDOCR METAB, V89, P2601, DOI 10.1210/jc.2004-0432
   Cipollone F, 2003, CIRCULATION, V108, P2776, DOI 10.1161/01.CIR.0000103700.05109.0D
   Das N, 2017, J PINEAL RES, V62, DOI 10.1111/jpi.12404
   de Jager J, 2006, ARTERIOSCL THROM VAS, V26, P1086, DOI 10.1161/01.ATV.0000215951.36219.a4
   DeFronzo RA, 2015, NAT REV DIS PRIMERS, V1, DOI 10.1038/nrdp.2015.19
   Depommier C, 2019, NAT MED, V25, P1096, DOI 10.1038/s41591-019-0495-2
   Dobiasova M, 2006, Vnitr Lek, V52, P64
   Du B, 2015, AM J PHYSIOL-HEART C, V308, pH1382, DOI 10.1152/ajpheart.00712.2014
   Dziuba J, 2014, DIABETES OBES METAB, V16, P628, DOI 10.1111/dom.12261
   Eggers KM, 2017, CLIN CHEM, V63, P223, DOI 10.1373/clinchem.2016.261495
   El-Azab MF, 2012, EUR J PHARMACOL, V690, P31, DOI 10.1016/j.ejphar.2012.06.002
   Evans PC, 2001, TRANSPLANTATION, V71, P457, DOI 10.1097/00007890-200102150-00020
   Fan L, 2018, J CLIN LAB ANAL, V32, DOI 10.1002/jcla.22244
   Fei N, 2013, ISME J, V7, P880, DOI 10.1038/ismej.2012.153
   Figueiredo VN, 2012, BLOOD PRESSURE, V21, P31, DOI 10.3109/08037051.2011.617045
   Fischer Andrew H, 2008, CSH Protoc, V2008, DOI 10.1101/pdb.prot4986
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Fox CS, 2015, CIRCULATION, V132, P691, DOI 10.1161/CIR.0000000000000230
   Franco-Obregon A, 2017, MSYSTEMS, V2, DOI 10.1128/mSystems.00018-17
   Franzosa EA, 2019, NAT MICROBIOL, V4, P293, DOI 10.1038/s41564-018-0306-4
   Fraulob JC, 2010, J CLIN BIOCHEM NUTR, V46, P212, DOI 10.3164/jcbn.09-83
   Fung CSC, 2015, CARDIOVASC DIABETOL, V14, DOI 10.1186/s12933-015-0304-2
   Garcia-Ropero A, 2018, EXPERT OPIN DRUG MET, V14, P1287, DOI 10.1080/17425255.2018.1551877
   Garvey WT, 2018, METABOLISM, V85, P32, DOI 10.1016/j.metabol.2018.02.002
   Gerstein HC, 2005, DIABETOLOGIA, V48, P1749, DOI 10.1007/s00125-005-1858-4
   GOLDNER JACQUES, 1938, AMER JOUR PATH, V14, P237
   Hawley SA, 2016, DIABETES, V65, P2784, DOI 10.2337/db16-0058
   Heeschen C, 2003, NEW ENGL J MED, V348, P1104, DOI 10.1056/NEJMoa022600
   Jabeen F, 2013, PAK J MED SCI, V29, P152, DOI 10.12669/pjms.291.2592
   Jaikumkao K, 2018, BBA-MOL BASIS DIS, V1864, P2021, DOI 10.1016/j.bbadis.2018.03.017
   Jain KS, 2007, BIOORGAN MED CHEM, V15, P4674, DOI 10.1016/j.bmc.2007.04.031
   Jiang YH, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.733681
   Jin L, 2021, PROTEIN CELL, V12, P346, DOI 10.1007/s13238-020-00785-9
   Kayama Y, 2015, INT J MOL SCI, V16, P25234, DOI 10.3390/ijms161025234
   Kong C, 2019, NUTRITION, V60, P175, DOI 10.1016/j.nut.2018.10.002
   Lee DM, 2018, CARDIOVASC DIABETOL, V17, DOI 10.1186/s12933-018-0708-x
   Lee TS, 2002, NAT MED, V8, P240, DOI 10.1038/nm0302-240
   Li K, 2019, FOOD FUNCT, V10, P1915, DOI 10.1039/c8fo02265h
   Liakos A, 2014, DIABETES OBES METAB, V16, P984, DOI 10.1111/dom.12307
   Libby P, 2006, AM J CLIN NUTR, V83, p456S
   Lippi G, 2015, PRIM CARE DIABETES, V9, P226, DOI 10.1016/j.pcd.2014.08.002
   Liu XM, 2022, NAT GENET, V54, P52, DOI 10.1038/s41588-021-00968-y
   Magenta A, 2013, INT J MOL SCI, V14, P17319, DOI 10.3390/ijms140917319
   Mahaffey KW, 2018, CIRCULATION, V137, P323, DOI 10.1161/CIRCULATIONAHA.117.032038
   Mamidi RNVS, 2014, DRUG METAB DISPOS, V42, P903, DOI 10.1124/dmd.113.056440
   Mishima E, 2018, AM J PHYSIOL-RENAL, V315, pF824, DOI 10.1152/ajprenal.00314.2017
   Neal B, 2017, NEW ENGL J MED, V377, P644, DOI 10.1056/NEJMoa1611925
   Nishikawa T, 2007, ANTIOXID REDOX SIGN, V9, P343, DOI 10.1089/ars.2006.1458
   Nordestgaard BG, 2014, LANCET, V384, P626, DOI 10.1016/S0140-6736(14)61177-6
   Patel A, 2008, NEW ENGL J MED, V358, P2560, DOI 10.1056/NEJMoa0802987
   Perkovic V, 2019, NEW ENGL J MED, V380, P2295, DOI 10.1056/NEJMoa1811744
   Pinter E, 1999, AM J PATHOL, V154, P1367, DOI 10.1016/S0002-9440(10)65391-6
   Ren J, 2018, TRENDS ENDOCRIN MET, V29, P699, DOI 10.1016/j.tem.2018.08.001
   Rocha M, 2010, CURR MED CHEM, V17, P3827, DOI 10.2174/092986710793205444
   Rosenwasser RF, 2013, DIABETES METAB SYNDR, V6, P453, DOI 10.2147/DMSO.S34416
   Schonbeck U, 2001, CIRCULATION, V104, P2266, DOI 10.1161/hc4401.099447
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Skyler JS, 2009, DIABETES CARE, V32, P187, DOI 10.2337/dc08-9026
   Steven S, 2017, REDOX BIOL, V13, P370, DOI 10.1016/j.redox.2017.06.009
   Stevens SL, 2016, BMJ-BRIT MED J, V354, DOI 10.1136/bmj.i4098
   Sun YN, 2014, BMJ OPEN, V4, DOI 10.1136/bmjopen-2013-004619
   Tan YK, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.758080
   Tang WHW, 2017, CIRC RES, V120, P1183, DOI 10.1161/CIRCRESAHA.117.309715
   Tangvarasittichai S, 2015, WORLD J DIABETES, V6, P456, DOI 10.4239/wjd.v6.i3.456
   Thongnak L, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-13206-5
   Thygesen K, 2018, KARDIOL POL, V76, P1383, DOI [10.5603/KP.2018.0203, 10.1161/CIR.0000000000000617, 10.1016/j.gheart.2018.08.004]
   Tian L, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.691878
   Tietge UJF, 2014, CURR OPIN LIPIDOL, V25, P94, DOI 10.1097/MOL.0000000000000051
   Varbo A, 2013, CIRCULATION, V128, P1298, DOI 10.1161/CIRCULATIONAHA.113.003008
   Vikram A, 2016, NAT COMMUN, V7, DOI 10.1038/ncomms12565
   Wang LR, 2016, CELL HOST MICROBE, V19, P227, DOI 10.1016/j.chom.2016.01.003
   Wang XL, 2021, FASEB J, V35, DOI 10.1096/fj.202000763RRR
   Xiang BY, 2021, CARDIOVASC DIABETOL, V20, DOI 10.1186/s12933-021-01266-x
   Yang XP, 2014, EUR J CLIN PHARMACOL, V70, P1149, DOI 10.1007/s00228-014-1730-x
   Yayla C, 2017, ANGIOLOGY, V68, P651, DOI 10.1177/0003319716664026
   Zhang JL, 2017, BBA-MOL BASIS DIS, V1863, P1556, DOI 10.1016/j.bbadis.2017.02.012
   Zheng YY, 2018, INT J BIOL MACROMOL, V112, P929, DOI 10.1016/j.ijbiomac.2018.02.072
   Zhou H, 2018, REDOX BIOL, V15, P335, DOI 10.1016/j.redox.2017.12.019
   Zinman B, 2016, NEW ENGL J MED, V374, P1094, DOI 10.1056/NEJMc1600827
NR 87
TC 5
Z9 5
U1 17
U2 22
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD FEB 23
PY 2022
VL 13
AR 839640
DI 10.3389/fphar.2022.839640
PG 16
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA ZQ2AD
UT WOS:000766912100001
PM 35281938
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Hasani, A
   Ebrahimzadeh, S
   Hemmati, F
   Khabbaz, A
   Hasani, A
   Gholizadeh, P
AF Hasani, Alka
   Ebrahimzadeh, Saba
   Hemmati, Fatemeh
   Khabbaz, Aytak
   Hasani, Akbar
   Gholizadeh, Pourya
TI The role of Akkermansia muciniphila in obesity, diabetes and
   atherosclerosis
SO JOURNAL OF MEDICAL MICROBIOLOGY
LA English
DT Review
DE Akkermansia muciniphila; atherosclerosis; diabetes; obesity; probiotic
ID DIET-INDUCED OBESITY; GUT MICROBIOTA; INTESTINAL MICROBIOTA;
   INSULIN-RESISTANCE; LOWERING ACTION; ADIPOSE-TISSUE; INFLAMMATION;
   MUCIN; METFORMIN; HOMEOSTASIS
AB Alteration in the composition of the gut microbiota can lead to a number of chronic clinical diseases. Akkermansia muciniphila is an anaerobic bacteria constituting 3-5% of the gut microbial community in healthy adults. This bacterium is responsible for degenerating mucin in the gut; its scarcity leads to diverse clinical disorders. In this review, we focus on the role of A. muciniphila in diabetes, obesity and atherosclerosis, as well as the use of this bacterium as a next- generation probiotic. In regard to obesity and diabetes, human and animal trials have shown that A. muciniphila controls the essential regulatory system of glucose and energy metabolism. However, the underlying mechanisms by which A. muciniphila alleviates the complications of obesity, diabetes and atherosclerosis are unclear. At the same time, its abundance suggests improved metabolic disorders, such as metabolic endotoxemia, adiposity insulin resistance and glucose tolerance. The role of A. muciniphila is implicated in declining aortic lesions and atherosclerosis. Well- characterized virulence factors, antigens and cell wall extracts of A. muciniphila may act as effector molecules in these diseases. These molecules may provide novel mechanisms and strategies by which this bacterium could be used as a probiotic for the treatment of obesity, diabetes and atherosclerosis.
C1 [Hasani, Alka; Khabbaz, Aytak] Tabriz Univ Med Sci, Fac Med, Sina Educ Res & Treatment Ctr, Clin Res Dev Unit, Tabriz, Iran.
   [Hasani, Alka; Hemmati, Fatemeh; Gholizadeh, Pourya] Tabriz Univ Med Sci, Fac Med, Dept Bacteriol & Virol, Tabriz, Iran.
   [Ebrahimzadeh, Saba] Urmia Univ, Fac Agr, Dept Food Sci & Technol, Orumiyeh, Iran.
   [Khabbaz, Aytak] Tabriz Univ Med Sci, Student Res Comm, Tabriz, Iran.
   [Hasani, Akbar] Tabriz Univ Med Sci, Fac Med, Dept Clin Biochem & Lab Sci, Tabriz, Iran.
   [Gholizadeh, Pourya] Tabriz Univ Med Sci, Immunol Res Ctr, Tabriz, Iran.
C3 Tabriz University of Medical Science; Tabriz University of Medical
   Science; Urmia University; Tabriz University of Medical Science; Tabriz
   University of Medical Science; Tabriz University of Medical Science
RP Gholizadeh, P (通讯作者)，Tabriz Univ Med Sci, Fac Med, Dept Bacteriol & Virol, Tabriz, Iran.; Gholizadeh, P (通讯作者)，Tabriz Univ Med Sci, Immunol Res Ctr, Tabriz, Iran.
EM poorya.gholizadeh@gmail.com
RI khabbaz, aytak/ABG-9768-2020; Hasani, Akbar/AAD-4553-2022
OI Hasani, Akbar/0000-0002-9461-821X; Khabbaz, Aytak/0000-0001-7758-0953;
   Gholizadeh, Pourya/0000-0002-1451-3996
CR Abuqwider JN, 2021, MICROORGANISMS, V9, DOI 10.3390/microorganisms9051098
   Allin KH, 2018, DIABETOLOGIA, V61, P810, DOI 10.1007/s00125-018-4550-1
   Ang ZW, 2016, FRONT IMMUNOL, V7, DOI 10.3389/fimmu.2016.00028
   Artis D, 2004, P NATL ACAD SCI USA, V101, P13596, DOI 10.1073/pnas.0404034101
   Belzer C, 2012, ISME J, V6, P1449, DOI 10.1038/ismej.2012.6
   Bevins CL, 2011, NAT REV MICROBIOL, V9, P356, DOI 10.1038/nrmicro2546
   Bian XY, 2019, FRONT MICROBIOL, V10, DOI 10.3389/fmicb.2019.02259
   Briggs DI, 2010, ENDOCRINOLOGY, V151, P4745, DOI 10.1210/en.2010-0556
   Cani PD, 2007, DIABETOLOGIA, V50, P2374, DOI 10.1007/s00125-007-0791-0
   Cani PD, 2009, GUT, V58, P1091, DOI 10.1136/gut.2008.165886
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   Cani PD, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.01765
   Cani PD, 2016, NAT REV ENDOCRINOL, V12, P133, DOI 10.1038/nrendo.2015.211
   Cani PD, 2012, GUT MICROBES, V3, P279, DOI 10.4161/gmic.19625
   Canny GO, 2008, INFECT IMMUN, V76, P3360, DOI 10.1128/IAI.00187-08
   Cario E, 2007, GASTROENTEROLOGY, V132, P1359, DOI 10.1053/j.gastro.2007.02.056
   Chelakkot C, 2018, EXP MOL MED, V50, DOI 10.1038/emm.2017.282
   Collado MC, 2007, APPL ENVIRON MICROB, V73, P7767, DOI 10.1128/AEM.01477-07
   Collado MC, 2008, AM J CLIN NUTR, V88, P894, DOI 10.1093/ajcn/88.4.894
   Cuesta CM, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22084235
   Curtiss LK, 2009, J LIPID RES, V50, pS340, DOI 10.1194/jlr.R800056-JLR200
   Dao MC, 2016, GUT, V65, P426, DOI 10.1136/gutjnl-2014-308778
   Davis LMG, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0025200
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Derrien M, 2004, INT J SYST EVOL MICR, V54, P1469, DOI 10.1099/ijs.0.02873-0
   Derrien M, 2011, FRONT MICROBIOL, V2, DOI 10.3389/fmicb.2011.00166
   Derrien M, 2010, GUT MICROBES, V1, P254, DOI 10.4161/gmic.1.4.12778
   Everard A, 2013, BEST PRACT RES CL GA, V27, P73, DOI 10.1016/j.bpg.2013.03.007
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Everard A, 2011, DIABETES, V60, P2775, DOI 10.2337/db11-0227
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Funderburgh JL, 2000, GLYCOBIOLOGY, V10, P951, DOI 10.1093/glycob/10.10.951
   Ganesh BP, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0074963
   Geurts L, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms7495
   Gholizadeh P, 2017, EUR J CLIN MICROBIOL, V36, P2043, DOI 10.1007/s10096-017-3036-2
   Gholizadeh P, 2019, MICROB PATHOGENESIS, V127, P48, DOI 10.1016/j.micpath.2018.11.031
   Grander C, 2018, GUT, V67, P892, DOI 10.1136/gutjnl-2016-313432
   Gu MJ, 2016, VET RES, V47, DOI 10.1186/s13567-016-0309-1
   Guo XF, 2017, BMC GENOMICS, V18, DOI 10.1186/s12864-017-4195-3
   Guzik TJ, 2006, J PHYSIOL PHARMACOL, V57, P505
   Hansen KB, 2011, J CLIN ENDOCR METAB, V96, pE1409, DOI 10.1210/jc.2011-0647
   Hooper LV, 2010, NAT REV IMMUNOL, V10, P159, DOI 10.1038/nri2710
   Johansson MEV, 2011, P NATL ACAD SCI USA, V108, P4659, DOI 10.1073/pnas.1006451107
   Jung UJ, 2014, INT J MOL SCI, V15, P6184, DOI 10.3390/ijms15046184
   Kahn CR, 2019, J CLIN INVEST, V129, P3990, DOI 10.1172/JCI129187
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kasahara K, 2017, J LIPID RES, V58, P519, DOI 10.1194/jlr.M072165
   Khan MT, 2014, CELL METAB, V20, P753, DOI 10.1016/j.cmet.2014.07.006
   Koboziev I, 2014, FREE RADICAL BIO MED, V68, P122, DOI 10.1016/j.freeradbiomed.2013.11.008
   Kosciow K, 2020, INT J BIOL MACROMOL, V149, P331, DOI 10.1016/j.ijbiomac.2020.01.246
   Kosciow K, 2019, MICROBIOLOGYOPEN, V8, DOI 10.1002/mbo3.796
   Kostic AD, 2014, GASTROENTEROLOGY, V146, P1489, DOI 10.1053/j.gastro.2014.02.009
   Kyriachenko Y, 2019, WORLD J DIABETES, V10, P154, DOI 10.4239/wjd.v10.i3.154
   Lee H, 2018, GUT MICROBES, V9, P155, DOI 10.1080/19490976.2017.1405209
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Li J, 2016, CIRCULATION, V133, P2434, DOI 10.1161/CIRCULATIONAHA.115.019645
   Li J, 2017, MICROBIOME, V5, DOI 10.1186/s40168-016-0222-x
   Li WZ, 2020, WORLD J DIABETES, V11, P293, DOI 10.4239/wjd.v11.i7.293
   Libby P, 2002, CIRCULATION, V105, P1135, DOI 10.1161/hc0902.104353
   Maslowski KM, 2011, NAT IMMUNOL, V12, P5, DOI 10.1038/ni0111-5
   Mello LV, 2010, FEBS LETT, V584, P2421, DOI 10.1016/j.febslet.2010.04.045
   Muccioli GG, 2010, MOL SYST BIOL, V6, DOI 10.1038/msb.2010.46
   Naito Y, 2018, J CLIN BIOCHEM NUTR, V63, P33, DOI 10.3164/jcbn.18-57
   Piya MK, 2013, J ENDOCRINOL, V216, pT1, DOI 10.1530/JOE-12-0498
   Plovier H, 2017, NAT MED, V23, P107, DOI 10.1038/nm.4236
   Pott J, 2012, EMBO REP, V13, P684, DOI 10.1038/embor.2012.96
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Qiu YF, 2014, CELL, V157, P1292, DOI 10.1016/j.cell.2014.03.066
   Rao RR, 2014, CELL, V157, P1279, DOI 10.1016/j.cell.2014.03.065
   Remely M, 2015, WIEN KLIN WOCHENSCHR, V127, P394, DOI 10.1007/s00508-015-0755-1
   Sallam T, 2014, J LIPID RES, V55, P1120, DOI 10.1194/jlr.M047548
   Santacruz A, 2010, BRIT J NUTR, V104, P83, DOI 10.1017/S0007114510000176
   Schaffaler A, 2010, TRENDS IMMUNOL, V31, P228, DOI 10.1016/j.it.2010.03.001
   Schneeberger M, 2015, SCI REP-UK, V5, DOI 10.1038/srep16643
   Seregin SS, 2017, CELL REP, V19, P733, DOI 10.1016/j.celrep.2017.03.080
   Shen J, 2016, ARTERIOSCL THROM VAS, V36, P1448, DOI 10.1161/ATVBAHA.116.307597
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Sonoyama K, 2009, APPL ENVIRON MICROB, V75, P6451, DOI 10.1128/AEM.00692-09
   Stoll LL, 2004, ARTERIOSCL THROM VAS, V24, P2227, DOI 10.1161/01.ATV.0000147534.69062.dc
   Suau A, 1999, APPL ENVIRON MICROB, V65, P4799
   SUEMORI S, 1991, P NATL ACAD SCI USA, V88, P11017, DOI 10.1073/pnas.88.24.11017
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Turnbaugh PJ, 2009, NATURE, V457, P480, DOI 10.1038/nature07540
   Turner JR, 2009, NAT REV IMMUNOL, V9, P799, DOI 10.1038/nri2653
   Vaishnava S, 2011, SCIENCE, V334, P255, DOI 10.1126/science.1209791
   Vallianou N, 2019, CURR OBES REP, V8, P317, DOI 10.1007/s13679-019-00352-2
   Van den Abbeele P, 2011, ENVIRON MICROBIOL, V13, P2667, DOI 10.1111/j.1462-2920.2011.02533.x
   van der Oost J, 2009, TRENDS BIOCHEM SCI, V34, P401, DOI 10.1016/j.tibs.2009.05.002
   Van Hul M, 2020, GUT MICROBES, V12, P1, DOI 10.1080/19490976.2020.1849998
   van Passel MWJ, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0016876
   Wang L, 2011, APPL ENVIRON MICROB, V77, P6718, DOI 10.1128/AEM.05212-11
   Xu WJ, 2020, BIOCHEM BIOPH RES CO, V529, P876, DOI 10.1016/j.bbrc.2020.06.116
   Xu Y, 2020, FRONT MICROBIOL, V11, DOI 10.3389/fmicb.2020.00219
   Yan H, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0059581
   Zatterale F, 2020, FRONT PHYSIOL, V10, DOI 10.3389/fphys.2019.01607
   Zhai QX, 2019, CRIT REV FOOD SCI, V59, P3227, DOI 10.1080/10408398.2018.1517725
   Zhang L, 2017, J ALZHEIMERS DIS, V60, P1241, DOI 10.3233/JAD-170020
   Zhang XY, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0071108
   Zheng HJ, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0166026
   Zhou ZY, 2016, ACTA PHARMACOL SIN, V37, P1063, DOI 10.1038/aps.2016.21
NR 101
TC 24
Z9 24
U1 17
U2 70
PU MICROBIOLOGY SOC
PI LONDON
PA 14-16 MEREDITH ST, LONDON, ENGLAND
SN 0022-2615
EI 1473-5644
J9 J MED MICROBIOL
JI J. Med. Microbiol.
PY 2021
VL 70
IS 10
AR 001435
DI 10.1099/jmm.0.001435
PG 9
WC Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology
GA WW6KE
UT WOS:000718022100005
PM 34623232
DA 2023-06-08
ER

PT J
AU Verschueren, MV
   Cramer - van der Welle, CM
   Tonn, M
   Schramel, FMNH
   Peters, BJM
   van de Garde, EMW
AF Verschueren, M. V.
   Cramer - van der Welle, C. M.
   Tonn, M.
   Schramel, F. M. N. H.
   Peters, B. J. M.
   van de Garde, E. M. W.
TI The association between gut microbiome affecting concomitant medication
   and the effectiveness of immunotherapy in patients with stage IV NSCLC
SO SCIENTIFIC REPORTS
LA English
DT Article
ID LUNG-CANCER; ANTIBIOTIC USE; EFFICACY; ATEZOLIZUMAB; DOCETAXEL; OAK
AB Several observational studies suggested that gut microbiome-affecting-medication impairs the effectiveness of immunotherapy in patients with metastatic non-small-cell lung cancer (NSCLC). We postulated that if the effectiveness of immunotherapy is affected by drug-related changes of the microbiome, a stronger association between the use of co-medication and overall survival (OS) will be observed in patients treated with immunotherapy as compared to patients treated with chemotherapy. In a retrospective matched cohort study, immunotherapy patients were matched (1:1) to patients treated with chemotherapy in the pre immunotherapy era. The association between the use of antibiotics, opioids, proton pump inhibitors, metformin and other antidiabetics on OS was assessed with multivariable cox-regression analyses. Interaction tests were applied to investigate whether the association differs between patients treated with immuno- or chemotherapy. A total of 442 patients were studied. The use of antibiotics was associated with worse OS (adjusted Hazard Ratio (aHR) 1.39, p = 0.02) independent of the type of therapy (chemotherapy or immunotherapy). The use of opioids was also associated with worse OS (aHR 1.33, p = 0.01). The other drugs studied showed no association with OS. Interaction term testing showed no effect modification by immuno- or chemotherapy for the association of antibiotics and opioids with OS. The use of antibiotics and opioids is similarly associated with worse outcomes in both chemotherapy and immunotherapy treated NSCLC patients. This suggests that the association is likely to be a consequence of confounding rather than disturbing the composition of the microbiome.
C1 [Verschueren, M. V.; Tonn, M.; Peters, B. J. M.; van de Garde, E. M. W.] St Antonius Hosp, Dept Clin Pharm, Koekoekslaan 1, NL-3435 CM Utrecht, Netherlands.
   [Cramer - van der Welle, C. M.] Santeon Hosp Grp, Utrecht, Netherlands.
   [Schramel, F. M. N. H.] St Antonius Hosp, Dept Pulm Dis, Utrecht, Netherlands.
   [van de Garde, E. M. W.] Univ Utrecht, Div Pharmacoepidemiol & Clin Pharmacol, Dept Pharmaceut Sci, Utrecht, Netherlands.
C3 St. Antonius Hospital Utrecht; St. Antonius Hospital Utrecht; Utrecht
   University
RP Verschueren, MV (通讯作者)，St Antonius Hosp, Dept Clin Pharm, Koekoekslaan 1, NL-3435 CM Utrecht, Netherlands.
EM m.verschueren@antoniusziekenhuis.nl
OI Verschueren, Marjon/0000-0002-2448-9168; Cramer - van der Welle,
   Christine/0000-0001-9587-9318
CR Brahmer J, 2015, NEW ENGL J MED, V373, P123, DOI 10.1056/NEJMoa1504627
   Chalabi M, 2020, ANN ONCOL, V31, P525, DOI [10.1016/j.annonc.2020.01.006, 10.1016/j.annoc.2020.01.006]
   Chen RQ, 2020, J HEMATOL ONCOL, V13, DOI 10.1186/s13045-020-00881-7
   Cortellini A, 2021, ANN ONCOL, V32, P1391, DOI 10.1016/j.annonc.2021.08.1744
   Cramer-Van Der Welle CM, 2018, EUR RESPIR J, V52
   Derosa L, 2018, ANN ONCOL, V29, P1437, DOI 10.1093/annonc/mdy103
   Drakaki A, 2020, ONCOIMMUNOLOGY, V9, DOI 10.1080/2162402X.2020.1824645
   Harris PA, 2009, J BIOMED INFORM, V42, P377, DOI 10.1016/j.jbi.2008.08.010
   Hasegawa T, 2018, J PALLIAT MED, V21, P1436, DOI 10.1089/jpm.2018.0044
   Herbst RS, 2016, LANCET, V387, P1540, DOI 10.1016/S0140-6736(15)01281-7
   Hooper LV, 2012, SCIENCE, V336, P1268, DOI 10.1126/science.1223490
   Iida N, 2013, SCIENCE, V342, P967, DOI 10.1126/science.1240527
   Kastelijn EA, 2019, CURR OPIN PULM MED, V25, P300, DOI 10.1097/MCP.0000000000000572
   Lurienne L, 2020, J THORAC ONCOL, V15, P1147, DOI 10.1016/j.jtho.2020.03.002
   Maier L, 2018, NATURE, V555, P623, DOI 10.1038/nature25979
   Mountzios G, 2020, CLIN LUNG CANCER
   Rittmeyer A, 2017, LANCET, V389, P255, DOI 10.1016/S0140-6736(16)32517-X
   Routy B, 2018, SCIENCE, V359, P91, DOI 10.1126/science.aan3706
   Singleton PA, 2015, CANCER-AM CANCER SOC, V121, P2681, DOI 10.1002/cncr.29460
   Union for International Cancer Control, 2014, NON SMALL CELL LUNG
   van de Garde EMW, 2020, ANN ONCOL, V31, P1779, DOI 10.1016/j.annonc.2020.09.007
   van de Garde EMW, 2019, EUR J HOSP PHARM, V26, P46, DOI 10.1136/ejhpharm-2017-001329
   Vila AV, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-019-14177-z
   Zhao S, 2019, LUNG CANCER, V130, P10, DOI 10.1016/j.lungcan.2019.01.017
   Zheng JG, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000019306
NR 25
TC 5
Z9 5
U1 0
U2 6
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD DEC 2
PY 2021
VL 11
IS 1
AR 23331
DI 10.1038/s41598-021-02598-0
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA XM0LQ
UT WOS:000728529200066
PM 34857829
OA gold, Green Published, Green Submitted
DA 2023-06-08
ER

PT J
AU Davies, N
   O'Sullivan, JM
   Plank, LD
   Murphy, R
AF Davies, Naomi
   O'Sullivan, Justin M.
   Plank, Lindsay D.
   Murphy, Rinki
TI Gut Microbial Predictors of Type 2 Diabetes Remission Following
   Bariatric Surgery
SO OBESITY SURGERY
LA English
DT Article
DE Bariatric surgery; Fecal microbiota; Bacteria; Bypass; Diabetes; Obesity
ID PROTON PUMP INHIBITORS; Y GASTRIC BYPASS; SLEEVE GASTRECTOMY;
   WEIGHT-LOSS; OBESE-PATIENTS; METFORMIN; DIET; INDIVIDUALS; SIGNATURES;
   MELLITUS
AB Purpose Distinct anatomical rearrangements of the gastrointestinal tract achieved by various types of bariatric surgery cause changes in nutrient intake and gut microbiota. The contribution of such gut microbiota changes to remission of type 2 diabetes (T2D) remains unclear. Aim We examined gut microbiota changes following banded Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG) in a randomised study, in relation to T2D remission. Materials and Methods Whole-metagenome shotgun sequencing was carried out on paired stool samples at pre- and 1-year post-surgery collected from 44 participants with T2D randomised to banded Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG). Taxonomic composition and predicted functional potential of the gut bacteria were identified using HUMANn2, and annotated using MetaCyc. Five-day dietary records (analysed using FoodWorks v8.0), body weight and diabetes status were recorded at both time points. Results RYGB participants had higher percentage excess weight loss than SG (p = 0.01), even though dietary intake was similar at 1-year post-surgery. Similar proportions achieved diabetes remission (HbA1c < 48 mmol/mol without medications) after either RYGB (68%) or SG (59%). RYGB resulted in increased abundances of Firmicutes and Proteobacteria, while SG resulted in increased Bacteroidetes. Pre-surgery, an increased abundance of Eubacteriaceae (p = 0.01) and Alistipes putredinis (p = 0.01) was observed in those who went on to remit from T2D post-surgery. Following surgery, Lachnospiraceae (p = 0.04) and Roseburia (p = 0.01) species were more abundant in those who had achieved T2D remission. Conclusions Specific stool bacterial taxa may signal likelihood of T2D remission after bariatric surgery which is potentially mediated by increases in Lachnospiraceae and Roseburia.
C1 [Davies, Naomi; Murphy, Rinki] Univ Auckland, Fac Med & Hlth Sci, Dept Med, Auckland, New Zealand.
   [Davies, Naomi; O'Sullivan, Justin M.; Murphy, Rinki] Univ Auckland, Maurice Wilkins Ctr, Auckland, New Zealand.
   [O'Sullivan, Justin M.] Univ Auckland, Liggins Inst, Auckland, New Zealand.
   [Plank, Lindsay D.] Univ Auckland, Dept Surg, Auckland, New Zealand.
C3 University of Auckland; University of Auckland; University of Auckland;
   University of Auckland
RP Murphy, R (通讯作者)，Univ Auckland, Fac Med & Hlth Sci, Dept Med, Auckland, New Zealand.; Murphy, R (通讯作者)，Univ Auckland, Maurice Wilkins Ctr, Auckland, New Zealand.
EM naomi.davies@auckland.ac.nz; justin.osullivan@auckland.ac.nz;
   l.plank@auckland.ac.nz; r.murphy@auckland.ac.nz
RI O'Sullivan, Justin/HDO-1639-2022
OI O'Sullivan, Justin/0000-0003-2927-450X
FU Auckland Medical Research Foundation [Project grant] Funding Source:
   Medline; Maurice Wilkins Centre [Flexible funding] Funding Source:
   Medline
CR Arrieta MC, 2012, FRONT IMMUNOL, V3, DOI 10.3389/fimmu.2012.00033
   Buchwald H, 2009, AM J MED, V122, P248, DOI 10.1016/j.amjmed.2008.09.041
   Caspi R, 2018, NUCLEIC ACIDS RES, V46, pD633, DOI 10.1093/nar/gkx935
   Chen H, 2017, AM J TRANSL RES, V9, P1243
   Dahiya DK, 2019, MICROBIOME AND METABOLOME IN DIAGNOSIS, THERAPY, AND OTHER STRATEGIC APPLICATIONS, P417, DOI 10.1016/B978-0-12-815249-2.00044-0
   Damms-Machado A, 2015, BIOMED RES INT, V2015, DOI 10.1155/2015/806248
   Davies NK, 2019, SURG OBES RELAT DIS, V15, P656, DOI 10.1016/j.soard.2019.01.033
   De Angelis M, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0076993
   De Filippo C, 2010, P NATL ACAD SCI USA, V107, P14691, DOI 10.1073/pnas.1005963107
   Duncan SH, 2008, INT J OBESITY, V32, P1720, DOI 10.1038/ijo.2008.155
   Federico A, 2016, IN VIVO, V30, P321
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Frank DN, 2007, P NATL ACAD SCI USA, V104, P13780, DOI 10.1073/pnas.0706625104
   Furet JP, 2010, DIABETES, V59, P3049, DOI 10.2337/db10-0253
   Graessler J, 2013, PHARMACOGENOMICS J, V13, P514, DOI 10.1038/tpj.2012.43
   Heinsen FA, 2016, OBESITY FACTS, V9, P379, DOI 10.1159/000449506
   Ilhan ZE, 2017, ISME J, V11, P2047, DOI 10.1038/ismej.2017.71
   Imhann F, 2017, GUT MICROBES, V8, P351, DOI 10.1080/19490976.2017.1284732
   Imhann F, 2016, GUT, V65, P740, DOI 10.1136/gutjnl-2015-310376
   Jackson DN, 2020, GUT MICROBES, V11, P285, DOI 10.1080/19490976.2019.1592421
   Jackson MA, 2016, GUT, V65, P749, DOI 10.1136/gutjnl-2015-310861
   Jandhyala SM, 2015, WORLD J GASTROENTERO, V21, P8787, DOI 10.3748/wjg.v21.i29.8787
   Kong LC, 2013, AM J CLIN NUTR, V98, P16, DOI 10.3945/ajcn.113.058743
   Lee WJ, 2011, ARCH SURG-CHICAGO, V146, P143, DOI 10.1001/archsurg.2010.326
   Lewis DA, 2013, FRONT CELL INFECT MI, V3, DOI 10.3389/fcimb.2013.00041
   Luijten JCHBM, 2019, OBES SURG, V29, P2338, DOI 10.1007/s11695-019-03863-y
   Maiuolo J, 2016, INT J CARDIOL, V213, P8, DOI 10.1016/j.ijcard.2015.08.109
   Mardinoglu A, 2016, CELL METAB, V23, P10, DOI 10.1016/j.cmet.2015.12.012
   McHardy IH, 2013, MICROBIOME, V1, DOI 10.1186/2049-2618-1-17
   Medina DA, 2017, PEERJ, V5, DOI 10.7717/peerj.3443
   Million M, 2018, HUM MICROBIOME J, V7-8, P10, DOI DOI 10.1016/J.HUMIC.2018.01.004
   Murphy R, 2018, OBES SURG, V28, P293, DOI 10.1007/s11695-017-2872-6
   Murphy R, 2017, OBES SURG, V27, P917, DOI 10.1007/s11695-016-2399-2
   Murphy R, 2016, BMJ OPEN, V6, DOI 10.1136/bmjopen-2016-011416
   Palleja A, 2016, GENOME MED, V8, DOI 10.1186/s13073-016-0312-1
   Papa E, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0039242
   Patrone V, 2016, FRONT MICROBIOL, V7, DOI 10.3389/fmicb.2016.00200
   Pories WJ, 2008, J CLIN ENDOCR METAB, V93, pS89, DOI 10.1210/jc.2008-1641
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Remely M, 2016, ENDOCR METAB IMMUNE, V16, P99, DOI 10.2174/1871530316666160831093813
   Sanmiguel CP, 2017, PSYCHOSOM MED, V79, P880, DOI 10.1097/PSY.0000000000000494
   Saulnier DM, 2011, GASTROENTEROLOGY, V141, P1782, DOI 10.1053/j.gastro.2011.06.072
   Sberro H, 2019, CELL, V178, P1245, DOI 10.1016/j.cell.2019.07.016
   Schauer PR, 2012, NEW ENGL J MED, V366, P1567, DOI 10.1056/NEJMoa1200225
   Scott KP, 2013, PHARMACOL RES, V69, P52, DOI 10.1016/j.phrs.2012.10.020
   Segata N, 2012, NAT METHODS, V9, P811, DOI [10.1038/NMETH.2066, 10.1038/nmeth.2066]
   Seto CT, 2014, MICROBIOME, V2, DOI 10.1186/2049-2618-2-42
   Tremaroli V, 2015, CELL METAB, V22, P228, DOI 10.1016/j.cmet.2015.07.009
   Turnbaugh PJ, 2009, J PHYSIOL-LONDON, V587, P4153, DOI 10.1113/jphysiol.2009.174136
   Turnbaugh PJ, 2009, NATURE, V457, P480, DOI 10.1038/nature07540
   Vaarala O, 2013, REV DIABET STUD, V9, P251
   Vidal J, 2008, OBES SURG, V18, P1077, DOI 10.1007/s11695-008-9547-2
   Vital M, 2017, MSYSTEMS, V2, DOI 10.1128/mSystems.00130-17
   VOGELS GD, 1976, BACTERIOL REV, V40, P403, DOI 10.1128/MMBR.40.2.403-468.1976
   Walker AW, 2011, ISME J, V5, P220, DOI 10.1038/ISMEJ.2010.118
   Wang Y, 2017, DIGIT COMMUN NETW, V3, P1, DOI 10.1016/j.dcan.2016.10.004
   Wolfe BM, 2016, CIRC RES, V118, P1844, DOI 10.1161/CIRCRESAHA.116.307591
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Zhang HS, 2009, P NATL ACAD SCI USA, V106, P2365, DOI 10.1073/pnas.0812600106
   Zhang YJ, 2015, INT J MOL SCI, V16, P7493, DOI 10.3390/ijms16047493
NR 60
TC 14
Z9 16
U1 1
U2 8
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0960-8923
EI 1708-0428
J9 OBES SURG
JI Obes. Surg.
PD SEP
PY 2020
VL 30
IS 9
BP 3536
EP 3548
DI 10.1007/s11695-020-04684-0
EA MAY 2020
PG 13
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA MO8RR
UT WOS:000534967600001
PM 32447634
DA 2023-06-08
ER

PT J
AU Yang, HJ
   Kim, MJ
   Kwon, DY
   Kim, DS
   Zhang, T
   Ha, C
   Park, S
AF Yang, Hye Jeong
   Kim, Min Jung
   Kwon, Dae Young
   Kim, Da Sol
   Zhang, Ting
   Ha, Chulgyu
   Park, Sunmin
TI Combination of Aronia, Red Ginseng, Shiitake Mushroom and Nattokinase
   Potentiated Insulin Secretion and Reduced Insulin Resistance with
   Improving Gut Microbiome Dysbiosis in Insulin Deficient Type 2 Diabetic
   Rats
SO NUTRIENTS
LA English
DT Article
DE aronia; ginseng; mushroom; pancreatectomy; type 2 diabetes; gut
   microbiome; insulin secretion
ID BETA-CELL FUNCTION; CULINARY-MEDICINAL MUSHROOM; VITAMIN-D DEFICIENCY;
   PPAR-GAMMA; UNDERCARBOXYLATED OSTEOCALCIN; GLUCOSE-TOLERANCE; OXIDATIVE
   STRESS; CLINICAL-TRIAL; SENSITIVITY; HYPERGLYCEMIA
AB The combination of freeze-dried aronia, red ginseng, ultraviolet-irradiated shiitake mushroom and nattokinase (AGM; 3.4:4.1:2.4:0.1) was examined to evaluate its effects on insulin resistance, insulin secretion and the gut microbiome in a non-obese type 2 diabetic animal model. Pancreatectomized (Px) rats were provided high fat diets supplemented with either (1) 0.5 g AGM (AGM-L), (2) 1 g AGM (AGM-H), (3) 1 g dextrin (control), or (4) 1 g dextrin with 120 mg metformin (positive-control) per kg body weight for 12 weeks. AGM (1 g) contained 6.22 mg cyanidin-3-galactose, 2.5 mg ginsenoside Rg3 and 244 mg beta-glucan. Px rats had decreased bone mineral density in the lumbar spine and femur and lean body mass in the hip and leg compared to the normal-control and AGM-L and AGM-H prevented the decrease. Visceral fat mass was lower in the control group than the normal-control group and its decrease was smaller with AGM-L and AGM-H. HOMA-IR was lower in descending order of the control, positive-control, AGM-L, AGM-H and normal-control groups. Glucose tolerance deteriorated in the control group and was improved by AGM-L and AGM-H more than in the positive-control group. Glucose tolerance is associated with insulin resistance and insulin secretion. Insulin tolerance indicated insulin resistance was highly impaired in diabetic rats, but it was improved in the ascending order of the positive-control, AGM-L and AGM-H. Insulin secretion capacity, measured by hyperglycemic clamp, was much lower in the control group than the normal-control group and it was improved in the ascending order of the positive-control, AGM-L and AGM-H. Diabetes modulated the composition of the gut microbiome and AGM prevented the modulation of gut microbiome. In conclusion, AGM improved glucose metabolism by potentiating insulin secretion and reducing insulin resistance in insulin deficient type 2 diabetic rats. The improvement of diabetic status alleviated body composition changes and prevented changes of gut microbiome composition.
C1 [Yang, Hye Jeong; Kim, Min Jung; Kwon, Dae Young] Korean Food Res Inst, Res Div Food Funct, Wanjoo 55365, South Korea.
   [Kim, Da Sol; Zhang, Ting; Park, Sunmin] Hoseo Univ, Obes Diabet Ctr, Dept Food & Nutr, Asan 31499, South Korea.
   [Ha, Chulgyu] Bio Campus Korea Polytech, Dept Bioproc Technol, Nonsan 32943, South Korea.
C3 Korea Food Research Institute (KFRI); Hoseo University
RP Park, S (通讯作者)，Hoseo Univ, Obes Diabet Ctr, Dept Food & Nutr, Asan 31499, South Korea.
EM yhj@kfri.re.kr; kmj@kfri.re.kr; dykwon@kfri.re.kr; tpfptm14@daum.net;
   zhangting92925@gmail.com; hckue@kopo.ac.kr; smpark@hoseo.edu
RI Park, Sun/GSD-9620-2022
OI Park, Sunmin/0000-0002-6092-8340
FU Ministry of Food, Agriculture, Forestry and Fisheries and the Korea
   Science and Engineering Foundation at 2017; Main Research Program of the
   Korea Food Research Institute (KFRI) [E0150302-04]; National Research
   Council of Science & Technology (NST) grant by the Korea government
   (MSIT) [CAP-16-07-KIOM]
FX Ministry of Food, Agriculture, Forestry and Fisheries and the Korea
   Science and Engineering Foundation at 2017, Main Research Program
   (E0150302-04) of the Korea Food Research Institute (KFRI) and the
   National Research Council of Science & Technology (NST) grant by the
   Korea government (MSIT) (No. CAP-16-07-KIOM).
CR Banjari I, 2017, FRONT NUTR, V4, DOI 10.3389/fnut.2017.00053
   Brunkwall L, 2017, DIABETOLOGIA, V60, P943, DOI 10.1007/s00125-017-4278-3
   Buranasinsup Shutipen, 2015, Journal of the Medical Association of Thailand, V98, pS16
   Choi Hyung Jin, 2011, Diabetes Care, V34, pe147, DOI 10.2337/dc11-0551
   Choi SB, 2005, ENDOCRINOLOGY, V146, P4786, DOI 10.1210/en.2004-1653
   DeFronzo RA, 2015, NAT REV DIS PRIMERS, V1, DOI 10.1038/nrdp.2015.19
   Dobbins RL, 2002, DIABETES, V51, P1825, DOI 10.2337/diabetes.51.6.1825
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   FUJITA M, 1995, BIOL PHARM BULL, V18, P1387
   Gao Y, 2013, J ETHNOPHARMACOL, V147, P509, DOI 10.1016/j.jep.2013.03.057
   Gower BA, 2013, J CLIN ENDOCR METAB, V98, pE1173, DOI 10.1210/jc.2013-1203
   Grotto D, 2016, INT J MED MUSHROOMS, V18, P861, DOI 10.1615/IntJMedMushrooms.v18.i10.20
   Hosokawa YA, 1996, J CLIN INVEST, V97, P180, DOI 10.1172/JCI118387
   Islam Md Shahidul, 2012, Methods Mol Biol, V933, P161, DOI 10.1007/978-1-62703-068-7_10
   Jeong SY, 2017, GENES NUTR, V12, DOI 10.1186/s12263-017-0585-z
   Kamweru PK, 2016, INT J MED MUSHROOMS, V18, P205, DOI 10.1615/IntJMedMushrooms.v18.i3.30
   Kim DS, 2018, DIABETES-METAB RES, V34, DOI 10.1002/dmrr.2944
   Kim HY, 2012, J ETHNOPHARMACOL, V142, P53, DOI 10.1016/j.jep.2012.04.012
   Kover K, 2015, BIOCHEM BIOPH RES CO, V462, P21, DOI 10.1016/j.bbrc.2015.04.095
   Lecka-Czernik B, 2017, DIABETOLOGIA, V60, P1163, DOI 10.1007/s00125-017-4269-4
   Lee BK, 2012, ASIA PAC J CLIN NUTR, V21, P536
   Lee HM, 2012, PHYTOTHER RES, V26, P1017, DOI 10.1002/ptr.3686
   Lee HJ, 2009, METABOLISM, V58, P1170, DOI 10.1016/j.metabol.2009.03.015
   Liang JX, 2017, J ENDOCR SOC, V1, P1085, DOI 10.1210/js.2017-00025
   Lyu M, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.02146
   Maschio BH, 2017, INT J MED MUSHROOMS, V19, P991, DOI 10.1615/IntJMedMushrooms.2017024498
   Mollah ML, 2009, PHYTOTHER RES, V23, P220, DOI 10.1002/ptr.2593
   Newsholme P, 2016, BIOCHEM J, V473, P4527, DOI 10.1042/BCJ20160503C
   O'Keefe JH, 2008, J AM COLL CARDIOL, V51, P249, DOI 10.1016/j.jacc.2007.10.016
   Pahwa R, 2016, METAB SYNDR RELAT D, V14, P239, DOI 10.1089/met.2016.29006.pah
   Park SH, 2014, J GINSENG RES, V38, P239, DOI 10.1016/j.jgr.2014.05.006
   Park S, 2018, AM J PHYSIOL-ENDOC M, V315, pE99, DOI 10.1152/ajpendo.00005.2018
   Park S, 2016, EXP BIOL MED, V241, P296, DOI 10.1177/1535370215606811
   Park S, 2016, J NUTR BIOCHEM, V27, P257, DOI 10.1016/j.jnutbio.2015.09.013
   Park S, 2014, CLIN NUTR, V33, P900, DOI 10.1016/j.clnu.2013.09.016
   Park S, 2011, EUR J NUTR, V50, P107, DOI 10.1007/s00394-010-0120-0
   Park S, 2008, BIOSCI BIOTECH BIOCH, V72, P2815, DOI 10.1271/bbb.80205
   Perry RJ, 2016, NATURE, V534, P213, DOI 10.1038/nature18309
   Reeds DN, 2011, DIABETES CARE, V34, P1071, DOI 10.2337/dc10-2299
   REEVES PG, 1993, J NUTR, V123, P1939, DOI 10.1093/jn/123.11.1939
   Rodriguez J, 2018, CURR OPIN CLIN NUTR, V21, P294, DOI 10.1097/MCO.0000000000000468
   Rugina D, 2015, OXID MED CELL LONGEV, V2015, DOI 10.1155/2015/429075
   Sabek OM, 2015, ENDOCRINOLOGY, V156, P3137, DOI 10.1210/EN.2015-1143
   Shin SS, 2018, J ETHNOPHARMACOL, V210, P80, DOI 10.1016/j.jep.2017.08.032
   Shishtar E, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0107391
   Sikora J, 2012, EUR J NUTR, V51, P549, DOI 10.1007/s00394-011-0238-8
   Simeonov Simeon B, 2002, Folia Med (Plovdiv), V44, P20
   Tang WH, 2011, J CLIN INVEST, V121, P4462, DOI 10.1172/JCI59291
   Wagner H, 2016, DIABETES CARE, V39, P345, DOI 10.2337/dc15-1057
   Wedick NM, 2012, AM J CLIN NUTR, V95, P925, DOI 10.3945/ajcn.111.028894
   Wen L, 2017, J NUTR, V147, p1468S, DOI 10.3945/jn.116.240754
   Westein E, 2017, CLIN SCI, V131, P1245, DOI 10.1042/CS20160391
   Yamane T, 2016, J NUTR BIOCHEM, V31, P106, DOI 10.1016/j.jnutbio.2016.02.004
   Yang HJ, 2016, NUTRIENTS, V8, DOI 10.3390/nu8030161
   Yuan Huiping, 2018, Oncotarget, V9, P6718, DOI 10.18632/oncotarget.22961
   Zhao LP, 2018, SCIENCE, V359, P1151, DOI 10.1126/science.aao5774
   Zhu W, 2012, FREE RADICAL BIO MED, V52, P314, DOI 10.1016/j.freeradbiomed.2011.10.483
NR 57
TC 19
Z9 22
U1 1
U2 15
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUL
PY 2018
VL 10
IS 7
AR 948
DI 10.3390/nu10070948
PG 19
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA GX2JK
UT WOS:000447544900151
PM 30041479
OA Green Submitted, Green Published, gold
DA 2023-06-08
ER

PT J
AU Gong, J
   Hu, ML
   Huang, ZY
   Fang, K
   Wang, DK
   Chen, QJ
   Li, JB
   Yang, DS
   Zou, X
   Xu, LJ
   Wang, KF
   Dong, H
   Lu, FE
AF Gong, Jing
   Hu, Meilin
   Huang, Zhaoyi
   Fang, Ke
   Wang, Dingkun
   Chen, Qingjie
   Li, Jingbin
   Yang, Desen
   Zou, Xin
   Xu, Lijun
   Wang, Kaifu
   Dong, Hui
   Lu, Fuer
TI Berberine Attenuates Intestinal Mucosal Barrier Dysfunction in Type 2
   Diabetic Rats
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE berberine; diabetes; intestinal mucosal barrier; gut immune system;
   gut-derived hormones
ID GUT MICROBIOTA; INSULIN-RESISTANCE; CROSS-TALK; METFORMIN; OBESITY;
   GLUCOSE; INFLAMMATION; KINASE; GLP-1
AB Background: Intestinal mucosal barrier dysfunction plays an important role in the development of diabetes mellitus (DM). Berberine (BBR), a kind of isoquinoline alkaloid, is widely known to be effective for both DM and diarrhea. Here, we explored whether the anti-diabetic effect of BBR was related to the intestine mucosal barrier.
   Methods and Results: The rat model of T2DM was established by high glucose and fat diet feeding and intravenous injection of streptozocin. Then, those diabetic rats were treated with BBR at different concentrations for 9 weeks. The results showed, in addition to hyperglycemia and hyperlipidemia, diabetic rats were also characterized by proinflammatory intestinal changes, altered gut-derived hormones, and 2.77-fold increase in intestinal permeability. However, the treatment with BBR significantly reversed the above changes in diabetic rats, presenting as the improvement of the high glucose and triglyceride levels, the relief of the inflammatory changes of intestinal immune system, and the attenuation of the intestinal barrier damage. BBR treatment at a high concentration also decreased the intestinal permeability by 27.5% in diabetic rats. Furthermore, BBR regulated the expressions of the molecules involved in TLR4/MyD88/NF-kappa B signaling pathways in intestinal tissue of diabetic rats.
   Conclusion: The hypoglycemic effects of BBR might be related to the improvement in gut-derived hormones and the attenuation of intestinal mucosal mechanic and immune barrier damages.
C1 [Gong, Jing; Hu, Meilin; Fang, Ke; Yang, Desen; Zou, Xin; Xu, Lijun; Wang, Kaifu; Dong, Hui; Lu, Fuer] Huazhong Univ Sci & Technol, Inst Integrated Tradit Chinese & Western Med, Tongji Hosp, Tongji Med Coll, Wuhan, Peoples R China.
   [Huang, Zhaoyi; Wang, Dingkun; Li, Jingbin] Huazhong Univ Sci & Technol, Dept Integrated Tradit Chinese & Western Med, Tongji Hosp, Tongji Med Coll, Wuhan, Peoples R China.
   [Chen, Qingjie] Huazhong Univ Sci & Technol, Dept Biochem & Mol Biol, Tongji Med Coll, Wuhan, Peoples R China.
   [Yang, Desen] Hubei Univ Tradit Chinese Med, Dept Pharm, Wuhan, Peoples R China.
C3 Huazhong University of Science & Technology; Huazhong University of
   Science & Technology; Huazhong University of Science & Technology; Hubei
   University of Chinese Medicine
RP Dong, H; Lu, FE (通讯作者)，Huazhong Univ Sci & Technol, Inst Integrated Tradit Chinese & Western Med, Tongji Hosp, Tongji Med Coll, Wuhan, Peoples R China.
EM tjdonghui@163.com; felu@tjh.tjmu.edu.cn
RI fang, ke/HNQ-1480-2023; Chen, Qingjie/S-5062-2019; xu, li/GNH-3667-2022
OI Chen, Qingjie/0000-0003-4699-5018; 
FU National Natural Science Foundation of China [81473637, 81373871,
   81473448]
FX This article is supported by the National Natural Science Foundation of
   China (No. 81473637, 81373871, 81473448).
CR Amasheh M, 2010, J CELL SCI, V123, P4145, DOI 10.1242/jcs.070896
   Anhe FF, 2015, GUT, V64, P872, DOI 10.1136/gutjnl-2014-307142
   [Anonymous], 2016, LANCET, V387, P1483, DOI 10.1016/S0140-6736(16)30185-4
   Antvorskov JC, 2014, DIABETOLOGIA, V57, P1770, DOI 10.1007/s00125-014-3265-1
   Burcelin R, 2012, PHYSIOLOGY, V27, P300, DOI 10.1152/physiol.00023.2012
   Caricilli AM, 2011, PLOS BIOL, V9, DOI 10.1371/journal.pbio.1001212
   DeFronzo RA, 2016, DIABETOLOGIA, V59, P1645, DOI 10.1007/s00125-016-3992-6
   Delzenne NM, 2015, DIABETOLOGIA, V58, P2206, DOI 10.1007/s00125-015-3712-7
   Dong H, 2013, PLANTA MED, V79, P437, DOI 10.1055/s-0032-1328321
   Dong H, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/591654
   Duca FA, 2015, NAT MED, V21, P506, DOI 10.1038/nm.3787
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Fritz JH, 2012, NATURE, V481, P199, DOI 10.1038/nature10698
   Garidou L, 2015, CELL METAB, V22, P100, DOI 10.1016/j.cmet.2015.06.001
   Graham S, 2004, GUT, V53, P1437, DOI 10.1136/gut.2004.042481
   He YY, 2016, GUT, V65, P33, DOI 10.1136/gutjnl-2014-307544
   Janssen S, 2011, P NATL ACAD SCI USA, V108, P2094, DOI 10.1073/pnas.1011508108
   Leng SH, 2004, ACTA PHARMACOL SIN, V25, P496
   Little TJ, 2011, PHYSIOL BEHAV, V104, P613, DOI 10.1016/j.physbeh.2011.04.038
   Luck H, 2015, CELL METAB, V21, P527, DOI 10.1016/j.cmet.2015.03.001
   Mardinoglu A, 2016, CELL METAB, V23, P10, DOI 10.1016/j.cmet.2015.12.012
   McCreight LJ, 2016, DIABETOLOGIA, V59, P426, DOI 10.1007/s00125-015-3844-9
   Meng ZJ, 2014, INT J PHARMACEUT, V467, P50, DOI 10.1016/j.ijpharm.2014.03.017
   Monteiro-Sepulveda M, 2015, CELL METAB, V22, P113, DOI 10.1016/j.cmet.2015.05.020
   Muller TD, 2015, MOL METAB, V4, P437, DOI 10.1016/j.molmet.2015.03.005
   Pirillo A, 2015, ATHEROSCLEROSIS, V243, P449, DOI 10.1016/j.atherosclerosis.2015.09.032
   Plociennikowska A, 2015, CELL MOL LIFE SCI, V72, P557, DOI 10.1007/s00018-014-1762-5
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Turner N, 2008, DIABETES, V57, P1414, DOI 10.2337/db07-1552
   Wang J, 2016, J DIABETES RES, V2016, DOI 10.1155/2016/4368380
   Wang Liwen, 2014, Biomed Res Int, V2014, P453972, DOI 10.1155/2014/453972
   Wang XT, 2014, NATURE, V514, P237, DOI 10.1038/nature13564
   Westwell-Roper CY, 2014, DIABETES, V63, P1698, DOI 10.2337/db13-0863
   Winer DA, 2016, CELL METAB, V23, P413, DOI 10.1016/j.cmet.2016.01.003
   Xu Y, 2013, JAMA-J AM MED ASSOC, V310, P948, DOI 10.1001/jama.2013.168118
   Yu YL, 2015, BIOCHEM PHARMACOL, V97, P173, DOI 10.1016/j.bcp.2015.07.012
   Yusta B, 2015, DIABETES, V64, P2537, DOI 10.2337/db14-1577
   Zhang QA, 2011, FOOD CHEM TOXICOL, V49, P61, DOI 10.1016/j.fct.2010.09.032
   Zhao HL, 2012, DIABETES, V61, P933, DOI 10.2337/db11-1164
   Zhou B, 2016, LANCET, V387, P1513, DOI 10.1016/S0140-6736(16)00618-8
   Zhou W, 2009, GASTROENTEROLOGY, V137, P1403, DOI 10.1053/j.gastro.2009.06.049
NR 42
TC 69
Z9 77
U1 7
U2 31
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD FEB 3
PY 2017
VL 8
AR 42
DI 10.3389/fphar.2017.00042
PG 12
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA EJ4WJ
UT WOS:000393217500001
PM 28217099
OA gold, Green Published, Green Submitted
DA 2023-06-08
ER

PT J
AU Wainwright, P
   Scorletti, E
   Byrne, CD
AF Wainwright, P.
   Scorletti, E.
   Byrne, C. D.
TI Type 2 Diabetes and Hepatocellular Carcinoma: Risk Factors and
   Pathogenesis
SO CURRENT DIABETES REPORTS
LA English
DT Review
DE Diabetes; Obesity; Hepatocellular carcinoma; Risk factors; Pathogenesis;
   Non-alcoholic fatty liver disease
ID FATTY LIVER-DISEASE; LIPID-PEROXIDATION PRODUCT; NONALCOHOLIC
   STEATOHEPATITIS; INSULIN-RESISTANCE; HEPATITIS-C; MITOCHONDRIAL
   DYSFUNCTION; EPIDEMIOLOGIC EVIDENCE; ABDOMINAL OBESITY; UNITED-STATES;
   CANCER
AB Purpose of Review This review aims to assess the epidemiological evidence for a link between type 2 diabetes and hepatocellular carcinoma and to investigate possible pathophysiological mechanisms.
   Recent Findings The presence of type 2 diabetes significantly increases the risk of developing hepatocellular carcinoma, and treatment with metformin may be associated with a lower risk. Treatment with insulin and sulphonylureas may be associated with increased risk. The pathophysiology underlying development of hepatocellular carcinoma in this context is complex and is likely to involve increased proinflammatory mediators, oxidative stress, JNK-1 activation, increased IGF-1 activity, altered gut microbiota and immunomodulation.
   Summary Hepatocellular carcinoma incidence is increasing and this is likely to be linked to the increasing incidence of type 2 diabetes, obesity and the metabolic syndrome. These conditions increase the risk of developing hepatocellular carcinoma, and a greater understanding of the underlying pathophysiology may help with the development of novel treatments.
C1 [Wainwright, P.] Southampton Univ Hosp, Clin Biochem, Southampton, Hants, England.
   [Wainwright, P.] Southampton Univ Hosp, Dept Lab Med, Chem Pathol & Metab Med, D Level Pathol Block, Tremona Rd, Southampton SO16 6YD, Hants, England.
   [Scorletti, E.; Byrne, C. D.] Univ Southampton, Fac Med, Human Dev & Hlth Acad Unit, Southampton, Hants, England.
   [Scorletti, E.; Byrne, C. D.] Univ Southampton, Natl Inst Hlth Res Southampton, Biomed Res Ctr Nutr, Southampton, Hants, England.
   [Scorletti, E.; Byrne, C. D.] Univ Southampton, Natl Inst Hlth Res Southampton, Resp Biomed Res Unit, Southampton, Hants, England.
   [Scorletti, E.; Byrne, C. D.] Southampton Univ Hosp, NHS Fdn Trust, Southampton, Hants, England.
C3 RLUK- Research Libraries UK; University of Southampton; RLUK- Research
   Libraries UK; University of Southampton; RLUK- Research Libraries UK;
   University of Southampton; RLUK- Research Libraries UK; University of
   Southampton; RLUK- Research Libraries UK; University of Southampton;
   RLUK- Research Libraries UK; University of Southampton
RP Wainwright, P (通讯作者)，Southampton Univ Hosp, Clin Biochem, Southampton, Hants, England.; Wainwright, P (通讯作者)，Southampton Univ Hosp, Dept Lab Med, Chem Pathol & Metab Med, D Level Pathol Block, Tremona Rd, Southampton SO16 6YD, Hants, England.
EM patrick.wainwright@uhs.nhs.uk
RI Scorletti, Eleonora/GMX-0079-2022
OI Byrne, Christopher D/0000-0001-6322-7753; Scorletti,
   Eleonora/0000-0002-7547-146X
FU Southampton National Institute for Health Research Biomedical Research
   Centre
FX C. D. Byrne is supported in part by the Southampton National Institute
   for Health Research Biomedical Research Centre.
CR Adams L. A., 2016, Current Hepatology Reports, V15, P96, DOI 10.1007/s11901-016-0299-5
   Alexander J, 2013, J GASTROEN HEPATOL, V28, P848, DOI 10.1111/jgh.12116
   Ascha MS, 2010, HEPATOLOGY, V51, P1972, DOI 10.1002/hep.23527
   Bhala N, 2011, HEPATOLOGY, V54, P1208, DOI 10.1002/hep.24491
   Birkenfeld AL, 2014, HEPATOLOGY, V59, P713, DOI 10.1002/hep.26672
   Brakenhielm E, 2004, P NATL ACAD SCI USA, V101, P2476, DOI 10.1073/pnas.0308671100
   Calle EE, 2004, NAT REV CANCER, V4, P579, DOI 10.1038/nrc1408
   Chamoun Z, 2013, BIOL CELL, V105, P219, DOI 10.1111/boc.201200036
   Chang QS, 2009, J HEPATOL, V50, P323, DOI 10.1016/j.jhep.2008.07.037
   Chen F, 2009, BBA-REV CANCER, V1796, P242, DOI 10.1016/j.bbcan.2009.06.005
   Chen Y, 2012, EUR J CANCER, V48, P2137, DOI 10.1016/j.ejca.2012.02.063
   Dapito DH, 2012, CANCER CELL, V21, P504, DOI 10.1016/j.ccr.2012.02.007
   Despres JP, 2006, NATURE, V444, P881, DOI 10.1038/nature05488
   Dongiovanni P, 2013, WORLD J GASTROENTERO, V19, P6969, DOI 10.3748/wjg.v19.i41.6969
   Dyal HK, 2016, DIGEST DIS SCI, V61, P636, DOI 10.1007/s10620-015-3983-3
   El-Serag H, 2003, ANN INTERN MED, V139, P817, DOI 10.7326/0003-4819-139-10-200311180-00009
   El-Serag HB, 2006, CLIN GASTROENTEROL H, V4, P369, DOI 10.1016/j.cgh.2005.12.007
   Ferlay J, 2015, INT J CANCER, V136, pE359, DOI 10.1002/ijc.29210
   George DK, 1998, GASTROENTEROLOGY, V114, P311, DOI 10.1016/S0016-5085(98)70482-2
   Guo X, 2013, SCI REP-UK, V3, DOI 10.1038/srep02981
   Hammerstad SS, 2015, FRONT ENDOCRINOL, V6, DOI 10.3389/fendo.2015.00134
   Hassan MM, 2002, HEPATOLOGY, V36, P1206, DOI 10.1053/jhep.2002.36780
   Hernandez-Vargas H, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009749
   Hirosumi J, 2002, NATURE, V420, P333, DOI 10.1038/nature01137
   Hoesel B, 2013, MOL CANCER, V12, DOI 10.1186/1476-4598-12-86
   Hsu CC, 2013, WORLD J GASTROENTERO, V19, P8880, DOI 10.3748/wjg.v19.i47.8880
   Hu WW, 2002, CARCINOGENESIS, V23, P1781, DOI 10.1093/carcin/23.11.1781
   IshShalom D, 1997, DIABETOLOGIA, V40, pS25, DOI 10.1007/s001250051393
   Jung UJ, 2014, INT J MOL SCI, V15, P6184, DOI 10.3390/ijms15046184
   Kawada N, 2009, J GASTROENTEROL, V44, P1190, DOI 10.1007/s00535-009-0112-0
   Koehler EM, 2016, HEPATOLOGY, V63, P138, DOI 10.1002/hep.27981
   Koh WP, 2013, BRIT J CANCER, V108, P1182, DOI 10.1038/bjc.2013.25
   Kwok R, 2016, GUT, V65, P1359, DOI 10.1136/gutjnl-2015-309265
   Lai SW, 2012, AM J GASTROENTEROL, V107, P46, DOI 10.1038/ajg.2011.384
   Larsson SC, 2007, BRIT J CANCER, V97, P1005, DOI 10.1038/sj.bjc.6603932
   Liu FF, 2015, TUMORI, V101, P206, DOI 10.5301/tj.5000241
   Liu J, 2004, MOL CELL BIOL, V24, P10844, DOI 10.1128/MCB.24.24.10844-10856.2004
   Liu YL, 2014, J HEPATOL, V61, P75, DOI 10.1016/j.jhep.2014.02.030
   Loomba R, 2012, HEPATOLOGY, V56, P943, DOI 10.1002/hep.25772
   Luedde T, 2007, CANCER CELL, V11, P119, DOI 10.1016/j.ccr.2006.12.016
   Lumeng CN, 2011, J CLIN INVEST, V121, P2111, DOI 10.1172/JCI57132
   Ma C, 2016, NATURE, V531, P253, DOI 10.1038/nature16969
   Marchesini G, 1999, AM J MED, V107, P450, DOI 10.1016/S0002-9343(99)00271-5
   Matteoni CA, 1999, GASTROENTEROLOGY, V116, P1413, DOI 10.1016/S0016-5085(99)70506-8
   Miele L, 2015, GASTROENT RES PRACT, V2015, DOI 10.1155/2015/570356
   Mittal S, 2016, CLIN GASTROENTEROL H, V14, P124, DOI 10.1016/j.cgh.2015.07.019
   Mittal S, 2015, CLIN GASTROENTEROL H, V13, P594, DOI 10.1016/j.cgh.2014.08.013
   Piscaglia F, 2016, HEPATOLOGY, V63, P827, DOI 10.1002/hep.28368
   Puri P, 2008, GASTROENTEROLOGY, V134, P568, DOI 10.1053/j.gastro.2007.10.039
   Ren Z, 2015, 21 ANN M INT LIV TRA
   Rhee S G, 2000, Sci STKE, V2000, ppe1
   Rinella ME, 2015, JAMA-J AM MED ASSOC, V313, P2263, DOI 10.1001/jama.2015.5370
   Romeo S, 2008, NAT GENET, V40, P1461, DOI 10.1038/ng.257
   Sakurai T, 2006, P NATL ACAD SCI USA, V103, P10544, DOI 10.1073/pnas.0603499103
   Schlesinger S, 2013, INT J CANCER, V132, P645, DOI 10.1002/ijc.27645
   Schulze K, 2015, NAT GENET, V47, P505, DOI 10.1038/ng.3252
   Singh R, 2009, HEPATOLOGY, V49, P87, DOI 10.1002/hep.22578
   Singh S, 2013, AM J GASTROENTEROL, V108, P881, DOI 10.1038/ajg.2013.5
   Sorrentino P, 2009, J HEPATOL, V50, P351, DOI 10.1016/j.jhep.2008.09.011
   Spickett CM, 2013, REDOX BIOL, V1, P145, DOI 10.1016/j.redox.2013.01.007
   Starley BQ, 2010, HEPATOLOGY, V51, P1820, DOI 10.1002/hep.23594
   STROHMEYER G, 1988, ANN NY ACAD SCI, V526, P245, DOI 10.1111/j.1749-6632.1988.tb55510.x
   Tanaka K, 2012, JPN J CLIN ONCOL, V42, P212, DOI 10.1093/jjco/hyr198
   Utzschneider KM, 2010, NAT REV ENDOCRINOL, V6, P26, DOI 10.1038/nrendo.2009.241
   Wang P, 2012, DIABETES-METAB RES, V28, P109, DOI 10.1002/dmrr.1291
   Wei YZ, 2008, WORLD J GASTROENTERO, V14, P193, DOI 10.3748/wjg.14.193
   White DL, 2008, J HEPATOL, V49, P831, DOI 10.1016/j.jhep.2008.08.006
   White DL, 2012, CLIN GASTROENTEROL H, V10, P1342, DOI 10.1016/j.cgh.2012.10.001
   Williams CD, 2011, GASTROENTEROLOGY, V140, P124, DOI 10.1053/j.gastro.2010.09.038
   Wolf MJ, 2014, CANCER CELL, V26, P549, DOI 10.1016/j.ccell.2014.09.003
   Wong CR, 2016, WORLD J GASTROENTERO, V22, P8294, DOI 10.3748/wjg.v22.i37.8294
   Wong RJ, 2014, HEPATOLOGY, V59, P2188, DOI 10.1002/hep.26986
   Yang SQ, 2000, ARCH BIOCHEM BIOPHYS, V378, P259, DOI 10.1006/abbi.2000.1829
   Yoshimoto S, 2013, NATURE, V499, P97, DOI 10.1038/nature12347
   Yuen MF, 2009, J GASTROEN HEPATOL, V24, P346, DOI 10.1111/j.1440-1746.2009.05784.x
   Zain SM, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0095604
   Zoller H, 2016, METABOLISM, V65, P1151, DOI 10.1016/j.metabol.2016.01.010
NR 77
TC 22
Z9 24
U1 0
U2 20
PU CURRENT MEDICINE GROUP
PI PHILADELPHIA
PA 400 MARKET STREET, STE 700, PHILADELPHIA, PA 19106 USA
SN 1534-4827
EI 1539-0829
J9 CURR DIABETES REP
JI Curr. Diabetes Rep.
PD MAR
PY 2017
VL 17
IS 4
AR 20
DI 10.1007/s11892-017-0851-x
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EQ2SX
UT WOS:000397922100001
PM 28290049
OA Green Accepted
DA 2023-06-08
ER

PT J
AU Wang, Y
   Xiao, H
   Liu, YX
   Tong, Q
   Yu, YY
   Qi, B
   Bu, XL
   Pan, TY
   Xing, Y
AF Wang, Yang
   Xiao, Hui
   Liu, Yanxia
   Tong, Qing
   Yu, Yanyan
   Qi, Bing
   Bu, Xiaoling
   Pan, Tianyuan
   Xing, Yu
TI Effects of Bu Shen Hua Zhuo formula on the LPS/TLR4 pathway and gut
   microbiota in rats with letrozole-induced polycystic ovary syndrome
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE gut microbiota; polycystic ovary syndrome; LPS; TLR4 pathway; rats;
   traditional Chinese medicine
ID TNF-ALPHA; EXPRESSION; WOMEN; MODEL; PCOS
AB Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in gynecology. Traditional Chinese medicine (TCM) is widely used for the treatment of PCOS in China. The Bu Shen Hua Zhuo formula (BSHZF), a TCM decoction, has shown great therapeutic efficacy in clinical practice. However, the mechanism underlying the BSHZF function in PCOS remains unclear. This study aimed to identify the potential mechanisms of action of BSHZF in the treatment of PCOS. PCOS-model rats treated with letrozole were administered different doses of BSHZF, metformin, and 1% carboxymethylcellulose. Serum sex hormones, fasting blood glucose, and fasting insulin levels were measured, and the morphology of the ovaries was observed in each group, including the normal group. The structure and abundance of the gut microbiota in rats were measured using 16S ribosomal RNA gene sequencing. Toll-like receptor 4 (TLR4) and phospho-NF-kappa B p65 levels in the ovarian tissue of the rats were detected using Western blotting. Furthermore, the levels of lipopolysaccharide (LPS) and inflammatory cytokines TNF-alpha, IL-6, and IL-8 in the serum of rats were detected by ELISA. The results showed that BSHZF administration was associated with a decrease in body weight, fasting blood glucose, fasting insulin, and testosterone and changes in ovarian morphology in PCOS-model rats. Moreover, BSHZF was associated with an increase in the alpha-diversity of gut microbiota, decrease in the relative abundance of Firmicutes, and increase in Lactobacillus and short chain fatty acid-producing bacteria (Allobaculum, Bacteroides, Ruminococcaceae_UCG-014). Furthermore, BSHZF may promote carbohydrate and protein metabolism. In addition, BSHZF was associated with a decrease in the serum level of LPS and TLR4 expression, thereby inhibiting the activation of the NF-kappa B signaling-mediated inflammatory response in ovarian tissue. Therefore, the beneficial effects of BSHZF on PCOS pathogenesis are associated with its ability to normalize gut microbiota function and inhibit PCOS-related inflammation.
C1 [Wang, Yang; Liu, Yanxia; Tong, Qing; Yu, Yanyan; Qi, Bing; Bu, Xiaoling; Xing, Yu] Beijing Univ Chinese Med, Dongfang Hosp, Dept Gynecol, Beijing, Peoples R China.
   [Xiao, Hui] Beijing Univ Chinese Med, Grad Sch, Beijing, Peoples R China.
   [Pan, Tianyuan] Zhejiang Univ, Affiliated Hosp 1, Sch Med, Dept Gen Med, Hangzhou, Zhejiang, Peoples R China.
C3 Beijing University of Chinese Medicine; Beijing University of Chinese
   Medicine; Zhejiang University
RP Xing, Y (通讯作者)，Beijing Univ Chinese Med, Dongfang Hosp, Dept Gynecol, Beijing, Peoples R China.
EM xingyu465@126.com
FU National Outstanding Youth Science Fund Project of National Natural
   Science Foundation of China; Fundamental Research Funds for the Central
   Universities of China; key specialty projects of the State
   Administration of traditional Chinese Medicine;  [81904241]; 
   [2018-JYBZZ-JS099]
FX Funding This work was supported by National Outstanding Youth Science
   Fund Project of National Natural Science Foundation of China (grant no.
   81904241), Fundamental Research Funds for the Central Universities of
   China (grant no. 2018-JYBZZ-JS099) and key specialty projects of the
   State Administration of traditional Chinese Medicine.
CR Abbott DH, 2021, CELL METAB, V33, P463, DOI 10.1016/j.cmet.2021.02.008
   Adak A, 2019, CELL MOL LIFE SCI, V76, P473, DOI 10.1007/s00018-018-2943-4
   Amiri M, 2017, METABOLISM, V73, P22, DOI 10.1016/j.metabol.2017.05.001
   Bruni V, 2022, REPROD SCI, V29, P668, DOI 10.1007/s43032-021-00515-4
   Cai Hong-Die, 2021, Zhongguo Zhong Yao Za Zhi, V46, P426, DOI 10.19540/j.cnki.cjcmm.20200723.402
   Chang ZP, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.670054
   Chen YT, 2021, NUTRIENTS, V13, DOI 10.3390/nu13072182
   Chu WW, 2020, FERTIL STERIL, V113, P1286, DOI 10.1016/j.fertnstert.2020.01.027
   Dabke K, 2019, J CLIN INVEST, V129, P4050, DOI 10.1172/JCI129194
   de Medeiros SF, 2017, REPROD BIOL ENDOCRIN, V15, DOI 10.1186/s12958-017-0313-y
   Ferrulli A, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22094692
   Gonzalez F, 2020, AM J PHYSIOL-ENDOC M, V319, pE744, DOI 10.1152/ajpendo.00228.2020
   Gonzalez F, 2019, J CLIN ENDOCR METAB, V104, P934, DOI 10.1210/jc.2018-01143
   Goodarzi MO, 2011, NAT REV ENDOCRINOL, V7, P219, DOI 10.1038/nrendo.2010.217
   Guan SQ, 2020, J ETHNOPHARMACOL, V251, DOI 10.1016/j.jep.2019.112525
   Guo YJ, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0153196
   Haung JH., 2004, CHIN J CLIN PHARM TH, V9, P1069
   He YF, 2020, FOOD FUNCT, V11, P5192, DOI [10.1039/c9fo02554e, 10.1039/C9FO02554E]
   Helvaci N, 2020, MATURITAS, V139, P12, DOI 10.1016/j.maturitas.2020.05.013
   Hirano Seishiro, 2012, Methods Mol Biol, V926, P87, DOI 10.1007/978-1-62703-002-1_6
   Huddleston H, 2017, FERTIL STERIL, V108, P426, DOI 10.1016/j.fertnstert.2017.06.026
   Insenser M, 2018, J CLIN ENDOCR METAB, V103, P2552, DOI 10.1210/jc.2017-02799
   Joham AE, 2021, J CLIN ENDOCR METAB, V106, P1585, DOI 10.1210/clinem/dgab134
   Ju TT, 2019, ISME J, V13, P1520, DOI 10.1038/s41396-019-0364-5
   Kafali H, 2004, ARCH MED RES, V35, P103, DOI 10.1016/j.arcmed.2003.10.005
   Kayedpoor P, 2017, INT J MORPHOL, V35, P723, DOI 10.4067/S0717-95022017000200054
   Kelley ST, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0146509
   Khajouei A, 2021, J REPROD IMMUNOL, V144, DOI 10.1016/j.jri.2021.103289
   Koliada A, 2017, BMC MICROBIOL, V17, DOI 10.1186/s12866-017-1027-1
   Krogh-Madsen R, 2006, AM J PHYSIOL-ENDOC M, V291, pE108, DOI 10.1152/ajpendo.00471.2005
   Lai L, 2017, BMJ OPEN, V7, DOI 10.1136/bmjopen-2016-011709
   Li X, 2017, BENEF MICROBES, V8, P421, DOI 10.3920/BM2016.0167
   Liang RN, 2019, MEDICINE, V98, DOI 10.1097/MD.0000000000016788
   Liao WT, 2019, J ETHNOPHARMACOL, V243, DOI 10.1016/j.jep.2019.112091
   Lindheim L, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0168390
   Lovvik TS, 2019, LANCET DIABETES ENDO, V7, P256, DOI 10.1016/S2213-8587(19)30002-6
   Macut D, 2017, DIABETES RES CLIN PR, V130, P163, DOI 10.1016/j.diabres.2017.06.011
   Mancini A, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22041667
   Masarwa R, 2021, PEDIATRICS, V147, DOI 10.1542/peds.2020-1610
   Milani C, 2017, MICROBIOL MOL BIOL R, V81, DOI 10.1128/MMBR.00036-17
   Mirzaei R, 2021, BIOMED PHARMACOTHER, V139, DOI 10.1016/j.biopha.2021.111661
   Mu HN, 2020, FRONT MICROBIOL, V11, DOI 10.3389/fmicb.2020.585066
   Mu SC, 2021, J ETHNOPHARMACOL, V267, DOI 10.1016/j.jep.2020.113534
   Ng NYH, 2019, PLOS MED, V16, DOI 10.1371/journal.pmed.1002953
   Nie QX, 2019, CRIT REV FOOD SCI, V59, P848, DOI 10.1080/10408398.2018.1536646
   Ojeda-Ojeda M, 2016, J REPROD IMMUNOL, V113, P9, DOI 10.1016/j.jri.2015.09.072
   Olesen SW, 2020, LANCET GASTROENTEROL, V5, P241, DOI 10.1016/S2468-1253(19)30452-2
   Plociennikowska A, 2015, CELL MOL LIFE SCI, V72, P557, DOI 10.1007/s00018-014-1762-5
   Qi XY, 2019, NAT MED, V25, P1225, DOI 10.1038/s41591-019-0509-0
   Qin L, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0217495
   Regidor PA, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22010384
   Rostamtabar M, 2021, J CELL PHYSIOL, V236, P824, DOI 10.1002/jcp.29912
   Shi XQ, 2021, CHIN J NAT MEDICINES, V19, P422, DOI 10.1016/S1875-5364(21)60041-9
   Teede HJ, 2018, FERTIL STERIL, V110, P364, DOI 10.1016/j.fertnstert.2018.05.004
   Thiruvengadam M, 2023, CRIT REV FOOD SCI, V63, P827, DOI 10.1080/10408398.2021.1954874
   Thursby E, 2017, BIOCHEM J, V474, P1823, DOI 10.1042/BCJ20160510
   Wang L, 2021, BIOMED PHARMACOTHER, V133, DOI 10.1016/j.biopha.2020.110958
   Wang Y., 2022, CHINA FAMILY PLANNIN, V14, P75
   Yang F, 2020, BIOMED PHARMACOTHER, V130, DOI 10.1016/j.biopha.2020.110503
   Yang JX, 2008, J ETHNOPHARMACOL, V119, P166, DOI 10.1016/j.jep.2008.06.027
   Yuan Bo-Chao, 2019, Zhongguo Zhong Yao Za Zhi, V44, P1080, DOI 10.19540/j.cnki.cjcmm.2019.0021
   Zeng B, 2019, RES MICROBIOL, V170, P43, DOI 10.1016/j.resmic.2018.09.002
   Zheng YJ, 2021, PHYTOMEDICINE, V88, DOI 10.1016/j.phymed.2020.153455
   Zhou J, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19102863
   Zhou L, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.00628
   Zou YC, 2020, FOOD FUNCT, V11, P2406, DOI 10.1039/c9fo01524h
   Zusso M, 2019, J NEUROINFLAMM, V16, DOI 10.1186/s12974-019-1538-9
NR 67
TC 2
Z9 2
U1 8
U2 15
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD AUG 9
PY 2022
VL 13
AR 891297
DI 10.3389/fendo.2022.891297
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 3Y6BK
UT WOS:000843808400001
PM 36017323
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Grandone, A
   Di Sessa, A
   Umano, GR
   Toraldo, R
   del Giudice, EM
AF Grandone, A.
   Di Sessa, A.
   Umano, G. R.
   Toraldo, R.
   del Giudice, E. Miraglia
TI New treatment modalities for obesity
SO BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
DE obesity; children; adolescent; pharmacotherapy; bariatric surgery
ID WHITE ADIPOSE-TISSUE; CONTROLLED-RELEASE PHENTERMINE/TOPIRAMATE;
   RANDOMIZED CONTROLLED-TRIAL; ACTIVATED PROTEIN-KINASE; BODY-MASS INDEX;
   WEIGHT-LOSS; FOOD-INTAKE; PEDIATRIC OBESITY; DOUBLE-BLIND; GUT
   MICROBIOTA
AB The treatment of childhood obesity represents a greater challenge for pediatricians. To date, it is multidisciplinary, including behavioral, dietary, pharmacological, and surgical options. Given the limited efficacy of available treatments, scientific research on finding new solutions is very active. Several drugs comprising Metformin, Glucagon-like peptide- 1 receptor agonists, Naltrexone-bupropion, Phentermine-Topiramate, and Lorcaserin have been studied as pediatric antiobesity agents. Findings from clinical trials showed a modest but significant effect of these drugs on weight loss, but long-term studies are needed to better define their exact role. Bariatric surgery is also promising for extremely obese adolescents. Moreover, a novel approach to treat obesity might be represented by compounds inducing browning of white adipose tissue, a complex process involved in body energy homeostasis, but at present evidence in humans is lacking. We aimed to review the current knowledge regarding the available new options for pediatric obesity treatment. (C) 2018 Elsevier Ltd. All rights reserved.
C1 [Umano, G. R.] Univ Campania Luigi Vanvitelli, Dept Woman Child & Gen & Specialized Surg, Naples, Italy.
   Via L De Crecchio 4, I-80138 Naples, Italy.
C3 Universita della Campania Vanvitelli
RP Umano, GR (通讯作者)，Univ Campania Luigi Vanvitelli, Dept Woman Child & Gen & Specialized Surg, Naples, Italy.
EM agrandone@gmail.com; anna.disessa@libero.it; giusi.umano@gmail.com;
   roberto.toraldo@unicampania.it;
   emanuele.miragliadelgiudice@unicampania.it
RI DI SESSA, ANNA/K-3831-2018; del Giudice, Emanuele
   Muraglia/AAC-2824-2019; Umano, Giuseppina/ABB-9980-2020
OI DI SESSA, ANNA/0000-0002-5877-3757; UMANO, GIUSEPPINA
   ROSARIA/0000-0002-5570-6620
CR Adeyemo MA, 2015, DIABETES OBES METAB, V17, P363, DOI 10.1111/dom.12426
   Alberdi G, 2013, FOOD CHEM, V141, P1530, DOI 10.1016/j.foodchem.2013.03.085
   Allison DB, 2012, OBESITY, V20, P330, DOI 10.1038/oby.2011.330
   Baggio LL, 2014, J CLIN INVEST, V124, P4223, DOI 10.1172/JCI78371
   Baskaran P, 2016, BRIT J PHARMACOL, V173, P2369, DOI 10.1111/bph.13514
   Blevins JE, 2015, PHYSIOL BEHAV, V152, P438, DOI 10.1016/j.physbeh.2015.05.023
   Blevins JE, 2015, AM J PHYSIOL-REG I, V308, pR431, DOI 10.1152/ajpregu.00441.2014
   Bray GA, 2003, OBES RES, V11, P722, DOI 10.1038/oby.2003.102
   Bray GA, 2018, ENDOCR REV, V39, P79, DOI 10.1210/er.2017-00253
   Brufani C, 2013, HORM RES PAEDIAT, V80, P78, DOI 10.1159/000353760
   Chanoine JP, 2005, JAMA-J AM MED ASSOC, V293, P2873, DOI 10.1001/jama.293.23.2873
   Chen Y, 2017, PHARMACOL THERAPEUT, V170, P1, DOI 10.1016/j.pharmthera.2016.10.004
   Chevalier C, 2015, CELL, V163, P1360, DOI 10.1016/j.cell.2015.11.004
   Cho S, 2017, J MED FOOD, V20, P323, DOI 10.1089/jmf.2016.3856
   Clement K, 2018, NAT MED, V24, P551, DOI 10.1038/s41591-018-0015-9
   Cohen P, 2016, MOL BIOL CELL, V27, P2523, DOI 10.1091/mbc.E15-10-0749
   Collet TH, 2017, MOL METAB, V6, P1321, DOI 10.1016/j.molmet.2017.06.015
   Cong HY, 2018, J DIABETES RES, V2018, DOI 10.1155/2018/9713259
   Danne T, 2017, J PEDIATR-US, V181, P146, DOI 10.1016/j.jpeds.2016.10.076
   Einfeld SL, 2014, AM J MED GENET A, V164, P2232, DOI 10.1002/ajmg.a.36653
   Freemark M, 2001, PEDIATRICS, V107, DOI 10.1542/peds.107.4.e55
   Gadde KM, 2011, LANCET, V377, P1341, DOI 10.1016/S0140-6736(11)60205-5
   Garvey WT, 2012, AM J CLIN NUTR, V95, P297, DOI 10.3945/ajcn.111.024927
   Goncalves JPL, 2018, TRENDS PHARMACOL SCI, V39, P402, DOI 10.1016/j.tips.2018.01.004
   Grossman DC, 2017, JAMA-J AM MED ASSOC, V317, P2417, DOI 10.1001/jama.2017.6803
   Herman WH, 2017, DIABETES CARE, V40, P1668, DOI 10.2337/dc17-1116
   Hoefig CS, 2016, THYROID, V26, P1656, DOI 10.1089/thy.2016.0178
   Hoffstedt J, 2007, J INTERN MED, V262, P131, DOI 10.1111/j.1365-2796.2007.01811.x
   Htike ZZ, 2017, DIABETES OBES METAB, V19, P524, DOI 10.1111/dom.12849
   Huvenne H, 2016, OBESITY FACTS, V9, P158, DOI 10.1159/000445061
   Inge TH, 2017, LANCET DIABETES ENDO, V5, P165, DOI 10.1016/S2213-8587(16)30315-1
   Janssen HLA, 2013, NEW ENGL J MED, V368, P1685, DOI 10.1056/NEJMoa1209026
   Kay JP, 2001, METABOLISM, V50, P1457, DOI 10.1053/meta.2001.28078
   Kelly AS, 2013, JAMA PEDIATR, V167, P355, DOI 10.1001/jamapediatrics.2013.1045
   Kelly AS, 2012, OBESITY, V20, P364, DOI 10.1038/oby.2011.337
   Kendall D, 2013, J CLIN ENDOCR METAB, V98, P322, DOI 10.1210/jc.2012-2710
   Khera R, 2016, JAMA-J AM MED ASSOC, V315, P2424, DOI 10.1001/jama.2016.7602
   Khidir N, 2018, OBES SURG, V28, P2040, DOI 10.1007/s11695-018-3139-6
   Khokhar A, 2017, PEDIATR CLIN N AM, V64, P1341, DOI 10.1016/j.pcl.2017.08.010
   Knowler WC, 2002, NEW ENGL J MED, V346, P393, DOI 10.1056/NEJMoa012512
   Koplowitz P, 2017, PEDIATRICS, V140, DOI 10.1542/peds.2017-1205
   Kuhnen P, 2016, NEW ENGL J MED, V375, P240, DOI 10.1056/NEJMoa1512693
   Kuppens RJ, 2016, CLIN ENDOCRINOL, V85, P979, DOI 10.1111/cen.13169
   Lawson EA, 2015, OBESITY, V23, P950, DOI 10.1002/oby.21069
   Li SG, 2018, METABOLISM, V78, P106, DOI 10.1016/j.metabol.2017.09.008
   Lockie SH, 2012, DIABETES, V61, P2753, DOI 10.2337/db11-1556
   Martin CK, 2011, J CLIN ENDOCR METAB, V96, P837, DOI 10.1210/jc.2010-1848
   Matta JA, 2007, J PHYSIOL-LONDON, V578, P397, DOI 10.1113/jphysiol.2006.121988
   McDonagh MS, 2014, JAMA PEDIATR, V168, P178, DOI 10.1001/jamapediatrics.2013.4200
   Mercader J, 2006, ENDOCRINOLOGY, V147, P5325, DOI 10.1210/en.2006-0760
   Michalsky M, 2012, SURG OBES RELAT DIS, V8, P1, DOI 10.1016/j.soard.2011.09.009
   Michalsky MP, 2014, SEMIN PEDIATR SURG, V23, P5, DOI 10.1053/j.sempedsurg.2013.10.020
   Nedergaard J, 2001, BBA-BIOENERGETICS, V1504, P82, DOI 10.1016/S0005-2728(00)00247-4
   Nicolucci AC, 2017, GASTROENTEROLOGY, V153, P711, DOI 10.1053/j.gastro.2017.05.055
   O'Brien PE, 2010, JAMA-J AM MED ASSOC, V303, P519, DOI 10.1001/jama.2010.81
   Olbers T, 2017, LANCET DIABETES ENDO, V5, P174, DOI 10.1016/S2213-8587(16)30424-7
   Ott V, 2013, DIABETES, V62, P3418, DOI 10.2337/db13-0663
   Paulus GF, 2016, OBESITY FACTS, V9, P344, DOI 10.1159/000448193
   Paz G, 2015, METABOLISM, V64, P146, DOI 10.1016/j.metabol.2014.07.014
   Quesada-Lopez T, 2016, NAT COMMUN, V7, DOI 10.1038/ncomms13479
   Reinehr T, 2009, OBESITY, V17, P1196, DOI 10.1038/oby.2009.17
   Richard D, 2000, NUTRITION, V16, P961, DOI 10.1016/S0899-9007(00)00452-4
   Ridaura VK, 2013, SCIENCE, V341, P1079, DOI 10.1126/science.1241214
   Riva A, 2017, ENVIRON MICROBIOL, V19, P95, DOI 10.1111/1462-2920.13463
   Rossi F, 2016, J CLIN ENDOCR METAB, V101, P3469, DOI 10.1210/jc.2015-4381
   Rothman RB, 2001, SYNAPSE, V39, P32, DOI 10.1002/1098-2396(20010101)39:1<32::AID-SYN5>3.0.CO;2-3
   Ryder JR, 2017, INT J OBESITY, V41, P90, DOI 10.1038/ijo.2016.185
   Sethi M, 2016, SURG OBES RELAT DIS, V12, P1697, DOI 10.1016/j.soard.2016.03.006
   Smith SR, 2010, NEW ENGL J MED, V363, P245, DOI 10.1056/NEJMoa0909809
   Styne DM, 2017, J CLIN ENDOCR METAB, V102, P709, DOI 10.1210/jc.2016-2573
   Suarez-Zamorano N, 2015, NAT MED, V21, P1497, DOI 10.1038/nm.3994
   Thienel M, 2016, INT J OBESITY, V40, P1707, DOI 10.1038/ijo.2016.149
   Thomas I, 2017, PEDIATR DIABETES, V18, P10, DOI 10.1111/pedi.12473
   Timmers S, 2011, CELL METAB, V14, P612, DOI 10.1016/j.cmet.2011.10.002
   TRIBOLLET E, 1992, BRAIN RES, V589, P15, DOI 10.1016/0006-8993(92)91156-9
   van der Aa MP, 2016, J OBES, V2016, DOI 10.1155/2016/7852648
   Vargas-Castillo A, 2017, ARCH MED RES, V48, P401, DOI 10.1016/j.arcmed.2017.10.002
   Wabitsch M, 2015, NEW ENGL J MED, V372, P48, DOI 10.1056/NEJMoa1406653
   Wang S, 2015, INT J OBESITY, V39, P967, DOI 10.1038/ijo.2015.23
   Wiegand S, 2010, EUR J ENDOCRINOL, V163, P585, DOI 10.1530/EJE-10-0570
   Wu J, 2013, GENE DEV, V27, P234, DOI 10.1101/gad.211649.112
   Yang X, 2017, BBA-MOL BASIS DIS, V1863, P1984, DOI 10.1016/j.bbadis.2016.09.019
   Zhang FL, 2018, FOOD FUNCT, V9, P2043, DOI [10.1039/C7FO01817G, 10.1039/c7fo01817g]
   Zhang Hai, 2013, PLoS One, V8, pe61477, DOI 10.1371/journal.pone.0061477
   Zhou GC, 2001, J CLIN INVEST, V108, P1167, DOI 10.1172/JCI200113505
NR 85
TC 26
Z9 26
U1 1
U2 15
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1521-690X
EI 1532-1908
J9 BEST PRACT RES CL EN
JI Best Pract. Res. Clin. Endoc. Metab.
PD AUG
PY 2018
VL 32
IS 4
BP 535
EP 549
DI 10.1016/j.beem.2018.06.007
PG 15
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA GU3HC
UT WOS:000445166200013
PM 30086873
DA 2023-06-08
ER

PT J
AU Kim, D
   Yu, J
   Wang, EK
   Lee, S
   Kim, JS
   Hwang, J
   Ku, CR
   Cho, YH
   Lee, EJ
AF Kim, Daham
   Yu, Juyeon
   Wang, Eun Kyung
   Lee, Soohyun
   Kim, Jung Seung
   Hwang, Jihwan
   Ku, Cheol Ryong
   Cho, Yoon Hee
   Lee, Eun Jig
TI Potential of an Enzyme Mixture of Glucose Oxidase, Glucosyl Transferase,
   and Fructosyl Transferase as an Antidiabetic Medicine
SO BIOMEDICINES
LA English
DT Article
DE glucose oxidase; glucosyl transferase; fructosyl transferase;
   antidiabetic effect; gut microbiota; lipid profile
ID DOUBLE-BLIND; PREVENTION; OBESITY; MICROFLORA; PREBIOTICS; METFORMIN;
   MUCOSA; H2O2
AB An enzyme mixture (EM) of glucose oxidase, glucosyl transferase, and fructosyl transferase can regulate glucose absorption into the body by converting carbohydrates in food to indigestible oligosaccharides. We evaluated the antidiabetic effects of repeated oral administration of EM in db/db mice. Seven-week-old db/db mice were divided into control, voglibose, and EM groups. Drugs were administered orally mixed with limited feed for one month. Glucose levels were measured every week. A meal tolerance test was conducted after overnight fasting, before the mice were sacrificed. There were no differences in body weight or food intake between the groups. EM treatment reduced blood glucose levels compared with those in the control group. Blood glucose levels during the meal tolerance test were significantly lower in the EM group than those in the control group. A significant decrease in triglyceride level and a tendency for decreased low-density lipoprotein were observed in the EM group compared with in the control group. The Bacteroidetes-to-Firmicutes ratio was higher in the EM group than that in the control group. EM may be useful for people at risk of hyperglycemia or diabetes who need to safely regulate their blood glucose levels. EM may also improve lipid and gut microbiota profiles.
C1 [Kim, Daham; Yu, Juyeon; Wang, Eun Kyung; Hwang, Jihwan; Ku, Cheol Ryong; Cho, Yoon Hee; Lee, Eun Jig] Yonsei Univ, Coll Med, Inst Endocrine Res, Dept Internal Med,Endocrinol, Seoul 03722, South Korea.
   [Lee, Soohyun; Lee, Eun Jig] Yonsei Univ, Coll Med, Grad Sch Med Sci, Dept Internal Med,Brain Korea 21 Project, Seoul 03722, South Korea.
   [Kim, Jung Seung] NERIG Inc, Seoul 04166, South Korea.
C3 Yonsei University; Yonsei University Health System; Yonsei University;
   Yonsei University Health System
RP Lee, EJ (通讯作者)，Yonsei Univ, Coll Med, Inst Endocrine Res, Dept Internal Med,Endocrinol, Seoul 03722, South Korea.; Lee, EJ (通讯作者)，Yonsei Univ, Coll Med, Grad Sch Med Sci, Dept Internal Med,Brain Korea 21 Project, Seoul 03722, South Korea.
EM kdhs82@yuhs.ac; juyeon07@yuhs.ac; ekwang06@yuhs.ac; shlee225@yuhs.ac;
   imkjs77@gmail.com; golden-ring@nensys.co.kr; cr079@yuhs.ac;
   wooriminji@gmail.com; ejlee423@yuhs.ac
OI Kim, Jungseung/0000-0002-2777-3156; Kim, Daham/0000-0003-1871-686X; Ku,
   Cheol Ryong/0000-0001-8693-9630; WANG, EUNKYUNG/0000-0002-3243-3009; yu,
   juyeon/0000-0001-9885-6998; Lee, Eun Jig/0000-0002-9876-8370
FU Korea Health Industry Development Institute (KHIDI) - Ministry of Health
   & Welfare, the Republic of Korea [HR18C0012]
FX This research was supported by a grant from the Korea Health Technology
   R&D Project through the Korea Health Industry Development Institute
   (KHIDI), funded by the Ministry of Health & Welfare, the Republic of
   Korea (grant number: HR18C0012).
CR Al-Lawati Jawad A, 2017, Oman Med J, V32, P177, DOI 10.5001/omj.2017.34
   Amer Diabet Assoc, 2021, DIABETES CARE, V44, pS100, DOI 10.2337/dc21-S008
   Amer Diabet Assoc, 2021, DIABETES CARE, V44, pS15, DOI 10.2337/dc21-S002
   Amer Diabet Assoc, 2021, DIABETES CARE, V44, pS111, DOI 10.2337/dc21-S009
   Amer Diabet Assoc, 2021, DIABETES CARE, V44, pS34, DOI 10.2337/dc21-S003
   Aroda VR, 2016, J CLIN ENDOCR METAB, V101, P1754, DOI 10.1210/jc.2015-3754
   Bankar SB, 2009, BIOTECHNOL ADV, V27, P489, DOI 10.1016/j.biotechadv.2009.04.003
   Botteaux A, 2009, MICROBES INFECT, V11, P537, DOI 10.1016/j.micinf.2009.02.009
   Bray GA, 2012, DIABETES CARE, V35, P731, DOI 10.2337/dc11-1299
   Corcionivoschi N, 2012, CELL HOST MICROBE, V12, P47, DOI 10.1016/j.chom.2012.05.018
   Czech MP, 2017, NAT MED, V23, P804, DOI 10.1038/nm.4350
   Daliri EBM, 2015, MICROBIOL MONOGR, V27, P221, DOI 10.1007/978-3-319-23177-8_10
   DiNicolantonio JJ, 2015, MAYO CLIN PROC, V90, P372, DOI 10.1016/j.mayocp.2014.12.019
   Gibson GR, 1999, J NUTR, V129, p1438S, DOI 10.1093/jn/129.7.1438S
   HUMMEL KP, 1966, SCIENCE, V153, P1127, DOI 10.1126/science.153.3740.1127
   Hyde PN, 2019, JCI INSIGHT, V4, DOI 10.1172/jci.insight.128308
   Saez-Lara MJ, 2015, BIOMED RES INT-UK, V2015, DOI 10.1155/2015/505878
   Kapat A, 1998, BIOTECHNOL LETT, V20, P319, DOI 10.1023/A:1005354608653
   Knaus UG, 2017, GUT MICROBES, V8, P67, DOI 10.1080/19490976.2017.1279378
   Knowler WC, 2002, NEW ENGL J MED, V346, P393, DOI 10.1056/NEJMoa012512
   Laigaard A, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-78404-0
   Langlands SJ, 2004, GUT, V53, P1610, DOI 10.1136/gut.2003.037580
   Ley RE, 2005, P NATL ACAD SCI USA, V102, P11070, DOI 10.1073/pnas.0504978102
   Ley RE, 2006, NATURE, V444, P1022, DOI 10.1038/4441022a
   Magkos F, 2020, NAT REV ENDOCRINOL, V16, P545, DOI 10.1038/s41574-020-0381-5
   Parks EJ, 2001, J NUTR, V131, p2772S, DOI 10.1093/jn/131.10.2772S
   Rehrig A., 2013, LAB ANIM SCI PROF, V1, P32
   Saeedi P, 2019, DIABETES RES CLIN PR, V157, DOI 10.1016/j.diabres.2019.107843
   Sako T, 2010, VET RES COMMUN, V34, P161, DOI 10.1007/s11259-010-9342-0
   Sasaki M, 2012, DIABETES OBES METAB, V14, P379, DOI 10.1111/j.1463-1326.2011.01539.x
   Sasaki M, 2007, J CLIN BIOCHEM NUTR, V41, P191, DOI 10.3164/jcbn.2007027
   Sasaki M, 2013, BMC GASTROENTEROL, V13, DOI 10.1186/1471-230X-13-81
   Turnbaugh PJ, 2008, CELL HOST MICROBE, V3, P213, DOI 10.1016/j.chom.2008.02.015
   van Baarlen P, 2013, TRENDS IMMUNOL, V34, P208, DOI 10.1016/j.it.2013.01.005
   van de Laar FA, 2005, DIABETES CARE, V28, P154, DOI 10.2337/diacare.28.1.154
   Wasilewski A, 2015, INFLAMM BOWEL DIS, V21, P1674, DOI 10.1097/MIB.0000000000000364
   Willett WC, 1999, NEW ENGL J MED, V341, P427, DOI 10.1056/NEJM199908053410607
   Wu SR, 2019, POULTRY SCI, V98, P828, DOI 10.3382/ps/pey393
   Zhang XY, 2017, DIABETES THER, V8, P293, DOI 10.1007/s13300-017-0226-y
   Zheng YJ, 2020, FRONT CELL INFECT MI, V10, DOI 10.3389/fcimb.2020.00360
NR 40
TC 0
Z9 1
U1 0
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9059
J9 BIOMEDICINES
JI Biomedicines
PD JUL
PY 2021
VL 9
IS 7
AR 745
DI 10.3390/biomedicines9070745
PG 12
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA TO0HZ
UT WOS:000676605800001
PM 34203399
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Qiu, YX
   Shen, LY
   Fu, LH
   Yang, J
   Cui, CQ
   Li, TT
   Li, XL
   Fu, CY
   Gao, XF
   Wang, WQ
   Ning, G
   Gu, YY
AF Qiu, Yixuan
   Shen, Linyan
   Fu, Lihong
   Yang, Jie
   Cui, Canqi
   Li, Tingting
   Li, Xuelin
   Fu, Chenyang
   Gao, Xianfu
   Wang, Weiqing
   Ning, Guang
   Gu, Yanyun
TI The glucose-lowering effects of alpha-glucosidase inhibitor require a
   bile acid signal in mice
SO DIABETOLOGIA
LA English
DT Article
DE Bile acid; Diabetes mellitus; Farnesoid X receptor; alpha-Glucosidase
   inhibitor; Pancreatic islet
ID FARNESOID-X-RECEPTOR; NUCLEAR RECEPTOR; GUT MICROBIOTA; BETA; FXR;
   ACARBOSE; THERAPY; LIVER; ACTIVATION; METFORMIN
AB Aims/hypothesis Bile-acid (BA) signalling is crucial in metabolism homeostasis and has recently been found to mediate the therapeutic effects of glucose-lowering treatments, including alpha-glucosidase inhibitor (AGI). However, the underlying mechanisms are yet to be clarified. We hypothesised that BA signalling may be required for the glucose-lowering effects and metabolic benefits of AGI. Methods Leptin receptor (Lepr)-knockout (KO) db/db mice and high-fat high-sucrose (HFHS)-fed Fxr (also known as Nr1h4)-KO mice were treated with AGI. Metabolic phenotypes and BA signalling in different compartments, including the liver, gut and endocrine pancreas, were evaluated. BA pool profiles were analysed by mass spectrometry. The islet transcription profile was assayed by RNA sequencing. The gut microbiome were assayed by 16S ribosomal RNA gene sequencing. Results AGI lowered microbial BA levels in BA pools of different compartments in the body, and increased gut BA reabsorption in both db/db and HFHS-fed mouse models via altering the gut microbiome. The AGI-induced changes in BA signalling (including increased activation of farnesoid X receptor [FXR] in the liver and inhibition of FXR in the ileum) echoed the alterations in BA pool size and composition in different organs. In Fxr-KO mice, the glucose- and lipid-lowering effects of AGI were partially abrogated, possibly due to the Fxr-dependent effects of AGI on decelerating beta cell replication, alleviating insulin hypersecretion and improving hepatic lipid and glucose metabolism. Conclusions/interpretation By regulating microbial BA metabolism, AGI elicited diverse changes in BA pool composition in different host compartments to orchestrate BA signalling in the whole body. The AGI-induced changes in BA signalling may be partly required for its glucose-lowering effects. Our study, hence, sheds light on the promising potential of regulating microbial BA and host FXR signalling for the treatment of type 2 diabetes. Data availability Sequencing data are available from the BioProject Database (accession no. PRJNA600345; ).
C1 [Qiu, Yixuan; Shen, Linyan; Fu, Lihong; Yang, Jie; Cui, Canqi; Li, Tingting; Li, Xuelin; Fu, Chenyang; Wang, Weiqing; Ning, Guang; Gu, Yanyun] Shanghai Natl Res Ctr Endocrine & Metab Dis, 197 Ruijin 2nd Rd, Shanghai 200025, Peoples R China.
   [Qiu, Yixuan; Shen, Linyan; Fu, Lihong; Yang, Jie; Cui, Canqi; Li, Tingting; Li, Xuelin; Fu, Chenyang; Wang, Weiqing; Ning, Guang; Gu, Yanyun] Shanghai Jiao Tong, Sch Med, Shanghai Inst Endocrine & Metab Dis, Ruijin Hosp, 197 Ruijin 2nd Rd, Shanghai 200025, Peoples R China.
   [Shen, Linyan] Tongji Univ, East Hosp, Dept Endocrinol, Sch Med, Shanghai, Peoples R China.
   [Gao, Xianfu] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Key Lab Syst Biol, Shanghai, Peoples R China.
C3 Shanghai Jiao Tong University; Tongji University; Chinese Academy of
   Sciences; Shanghai Institutes for Biological Sciences, CAS
RP Ning, G; Gu, YY (通讯作者)，Shanghai Natl Res Ctr Endocrine & Metab Dis, 197 Ruijin 2nd Rd, Shanghai 200025, Peoples R China.; Ning, G; Gu, YY (通讯作者)，Shanghai Jiao Tong, Sch Med, Shanghai Inst Endocrine & Metab Dis, Ruijin Hosp, 197 Ruijin 2nd Rd, Shanghai 200025, Peoples R China.
EM gning@sibs.ac.cn; guyanyun@hotmail.com
RI Gao, Xianfu/C-7802-2009; Li, Tingting/HKE-0812-2023; qiu,
   yixuan/AAF-8393-2021
OI qiu, yixuan/0000-0003-0481-6923
FU National Nature Science Foundation of China [81870555, 81930021,
   81670761]; Prevention and Control of Major Chronic Non-Communicable
   Diseases Research of China [2018YFC1313804]
FX This work was supported by grants from the National Nature Science
   Foundation of China (81870555, 81930021, 81670761) and the Prevention
   and Control of Major Chronic Non-Communicable Diseases Research of China
   (2018YFC1313804).
CR BALFOUR JA, 1993, DRUGS, V46, P1025, DOI 10.2165/00003495-199346060-00007
   Benner C, 2014, BMC GENOMICS, V15, DOI 10.1186/1471-2164-15-620
   Bertaggia E, 2017, AM J PHYSIOL-ENDOC M, V313, pE121, DOI 10.1152/ajpendo.00409.2016
   Boitard C, 2012, DIABETES OBES METAB, V14, DOI 10.1111/j.1463-1326.2012.01693.x
   Cariou B, 2006, J BIOL CHEM, V281, P11039, DOI 10.1074/jbc.M510258200
   Chen K, 2017, CELL, V170, P492, DOI 10.1016/j.cell.2017.06.042
   Corkey BE, 2012, DIABETES, V61, P4, DOI 10.2337/db11-1483
   DeFronzo RA, 2011, J CLIN ENDOCR METAB, V96, P2354, DOI 10.1210/jc.2011-0246
   DiNicolantonio JJ, 2015, OPEN HEART, V2, DOI [10.1136/openhrt-2015-000326, 10.1136/openhrt-2014-000230]
   Flynn CR, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms8715
   Fu LH, 2018, J ENDOCRINOL, V238, P137, DOI 10.1530/JOE-17-0709
   Fu T, 2019, CELL, V176, P1098, DOI 10.1016/j.cell.2019.01.036
   Gonzalez FJ, 2016, GASTROENTEROLOGY, V151, P845, DOI 10.1053/j.gastro.2016.08.057
   Gu YY, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-01682-2
   Gu YY, 2011, DIABETES, V60, P827, DOI 10.2337/db10-1194
   Haeusler RA, 2012, CELL METAB, V15, P65, DOI 10.1016/j.cmet.2011.11.010
   Harrison DE, 2014, AGING CELL, V13, P273, DOI 10.1111/acel.12170
   Jia W, 2018, NAT REV GASTRO HEPAT, V15, P111, DOI 10.1038/nrgastro.2017.119
   Jiang CT, 2015, J CLIN INVEST, V125, P386, DOI 10.1172/JCI76738
   Joyce SA, 2016, ANNU REV FOOD SCI T, V7, P313, DOI 10.1146/annurev-food-041715-033159
   Kahn SE, 2014, LANCET, V383, P1068, DOI 10.1016/S0140-6736(13)62154-6
   Kim I, 2007, J LIPID RES, V48, P2664, DOI 10.1194/jlr.M700330-JLR200
   Kong B, 2012, HEPATOLOGY, V56, P1034, DOI 10.1002/hep.25740
   Kumar DP, 2016, J BIOL CHEM, V291, P6626, DOI 10.1074/jbc.M115.699504
   Liao XY, 2019, EBIOMEDICINE, V44, P665, DOI 10.1016/j.ebiom.2019.03.057
   Lu TT, 2000, MOL CELL, V6, P507, DOI 10.1016/S1097-2765(00)00050-2
   Ma K, 2006, J CLIN INVEST, V116, P1102, DOI 10.1172/JCI25604
   Makishima M, 1999, SCIENCE, V284, P1362, DOI 10.1126/science.284.5418.1362
   McGavigan AK, 2017, GUT, V66, P226, DOI 10.1136/gutjnl-2015-309871
   Neuschwander-Tetri BA, 2015, LANCET, V385, P956, DOI 10.1016/S0140-6736(14)61933-4
   Nozaki Y, 2009, J HEPATOL, V51, P548, DOI 10.1016/j.jhep.2009.05.017
   Parks DJ, 1999, SCIENCE, V284, P1365, DOI 10.1126/science.284.5418.1365
   Parseus A, 2017, GUT, V66, P429, DOI 10.1136/gutjnl-2015-310283
   Patankar JV, 2018, AM J PHYSIOL-ENDOC M, V314, pE418, DOI 10.1152/ajpendo.00172.2017
   Perry RJ, 2016, NATURE, V534, P213, DOI 10.1038/nature18309
   Puri S, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-018-02939-0
   Reaven GM, 2009, DIABETES VASC DIS RE, V6, P133, DOI 10.1177/1479164109336038
   Ryan KK, 2014, NATURE, V509, P183, DOI 10.1038/nature13135
   Sayin SI, 2013, CELL METAB, V17, P225, DOI 10.1016/j.cmet.2013.01.003
   Schauer PR, 2017, NEW ENGL J MED, V376, P641, DOI 10.1056/NEJMoa1600869
   Schittenhelm B, 2015, ENDOCRINOLOGY, V156, P1263, DOI 10.1210/en.2014-1751
   Sjostrom L, 2004, NEW ENGL J MED, V351, P2683, DOI 10.1056/NEJMoa035622
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Swisa A, 2017, J CLIN INVEST, V127, P230, DOI 10.1172/JCI88015
   Togashi Y, 2014, ENDOCRINOLOGY, V155, P1643, DOI 10.1210/en.2013-1796
   Tremaroli V, 2015, CELL METAB, V22, P228, DOI 10.1016/j.cmet.2015.07.009
   van der Meulen T, 2015, J MOL ENDOCRINOL, V54, pR103, DOI 10.1530/JME-14-0290
   Wahlstrom A, 2016, CELL METAB, V24, P41, DOI 10.1016/j.cmet.2016.05.005
   Wang HB, 1999, MOL CELL, V3, P543, DOI 10.1016/S1097-2765(00)80348-2
   Wang SJ, 2018, J DIABETES, V10, P874, DOI 10.1111/1753-0407.12771
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Xu YL, 2015, DIABETOLOGIA, V58, P2064, DOI 10.1007/s00125-015-3670-0
   Yang WY, 2014, LANCET DIABETES ENDO, V2, P46, DOI 10.1016/S2213-8587(13)70021-4
   Zhang EM, 2019, CELL METAB, V29, P64, DOI 10.1016/j.cmet.2018.09.008
   Zhang YQ, 2006, P NATL ACAD SCI USA, V103, P1006, DOI 10.1073/pnas.0506982103
   Zhang ZG, 2014, NAT COMMUN, V5, DOI 10.1038/ncomms6493
NR 56
TC 8
Z9 9
U1 2
U2 13
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0012-186X
EI 1432-0428
J9 DIABETOLOGIA
JI Diabetologia
PD MAY
PY 2020
VL 63
IS 5
BP 1002
EP 1016
DI 10.1007/s00125-020-05095-7
EA FEB 2020
PG 15
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA LB8XL
UT WOS:000515945900001
PM 32034442
OA Green Published, hybrid
DA 2023-06-08
ER

PT J
AU Kong, WJ
   Vernieri, C
   Foiani, M
   Jiang, JD
AF Kong, Wei-Jia
   Vernieri, Claudio
   Foiani, Marco
   Jiang, Jian-Dong
TI Berberine in the treatment of metabolism-related chronic diseases: A
   drug cloud (dCloud) effect to target multifactorial disorders
SO PHARMACOLOGY & THERAPEUTICS
LA English
DT Review
DE Berberine; Metabolites; Gut microbiota; Short chain fatty acids; Drug
   cloud; Energy metabolism disorders
ID DENSITY-LIPOPROTEIN RECEPTOR; ACTIVATED PROTEIN-KINASE; GUT MICROBIOTA;
   INSULIN-RESISTANCE; UP-REGULATION; INFLAMMASOME ACTIVATION;
   MOLECULAR-MECHANISMS; LOWERING EFFICACY; IMPROVES; LIVER
AB Berberine (BBR) is a multi-target drug (MTD) that has proven effective in the treatment of metabolism-related chronic diseases (CDs). However, the mode of action (MOA) of BBR remains to be clarified. At a cellular level, the inhibitory effect of BBR on mitochondrial enzymes is probably responsible for many of its biological activities, including the activation of low-density lipoprotein receptor (LDLR), AMP-activated protein kinase (AMPK) and insulin receptor (InsR); these biological activities contribute to ameliorate peripheral blood metabolic profiles, e.g. by reducing plasma lipids and glucose levels, thus improving signs and symptoms of metabolic disorders. In this perspective, BBR acts as a targeted therapy. However, it also exerts pleiotropic systemic activities on some root causes of CDs that include antioxidant / anti-inflammatory effects and modifications of gut microbiota composition and metabolism, which may also contribute to its disease-modifying effects. After reviewing the different MOA of BBR, here we propose that BBR acts through a drug-cloud (dCloud) mechanism, as different to a drug-target effect. The dCloud here is defined as a group of terminal molecular events induced by the drug (or/and related metabolites), as well as the network connections among them. In this scenario, the therapeutic efficacy of BBR is the result of its dCloud effect acting on symptoms/signs as well as on root causes of the diseases. The dCloud concept is applicable to other established MTDs, such as aspirin, metformin, statins as well as to nutrient starvation, thus providing a novel instrument for the design of effective therapies against multifactorial metabolism-related CDs. (C) 2020 Elsevier Inc. All rights reserved.
C1 [Kong, Wei-Jia; Jiang, Jian-Dong] Chinese Acad Med Sci & Peking Union Med Coll, Inst Med Biotechnol, Beijing 100050, Peoples R China.
   [Vernieri, Claudio] Fdn IRCCS Ist Nazl Tumori, Milan, Italy.
   [Vernieri, Claudio; Foiani, Marco] Fdn Ist FIRC Oncol Mol, I-20139 Milan, Italy.
   [Foiani, Marco] Univ Milan, Milan, Italy.
   [Jiang, Jian-Dong] Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, State Key Lab Bioact Nat Prod & Funct, Beijing 100050, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Institute of Medicinal Biotechnology - CAMS; Peking Union Medical
   College; Fondazione IRCCS Istituto Nazionale Tumori Milan; IFOM - FIRC
   Institute of Molecular Oncology; University of Milan; Chinese Academy of
   Medical Sciences - Peking Union Medical College; Peking Union Medical
   College
RP Jiang, JD (通讯作者)，Chinese Acad Med Sci & Peking Union Med Coll, Inst Med Biotechnol, Beijing 100050, Peoples R China.; Foiani, M (通讯作者)，Fdn Ist FIRC Oncol Mol, I-20139 Milan, Italy.
EM marco.foiani@ifom.eu; jiangjd@imm.ac.cn
RI Foiani, Marco/M-8234-2014; Vernieri, Claudio/J-7426-2018
OI Foiani, Marco/0000-0003-4795-834X; Vernieri, Claudio/0000-0003-1577-8176
FU National Science Foundation of China [81621064]; CAMSMajor Collaborative
   Innovation Project [2016-I2M-1-011]
FX This work was supported by The National Science Foundation of China
   (81621064), as well as the CAMSMajor Collaborative Innovation Project
   (No. 2016-I2M-1-011).
CR Alam MZ, 2014, CNS NEUROL DISORD-DR, V13, P383, DOI 10.2174/18715273113126660151
   An HY, 2016, J ENDOCRINOL, V228, pR97, DOI 10.1530/JOE-15-0447
   [Anonymous], 2016, J RENIN ANGIOTENSIN
   Batty JA, 2018, SYST REV-LONDON, V7, DOI 10.1186/s13643-018-0779-5
   Bilandzic A, 2016, PLOS MED, V13, DOI 10.1371/journal.pmed.1001987
   Cao SJ, 2013, J ETHNOPHARMACOL, V149, P576, DOI 10.1016/j.jep.2013.07.025
   Cao Y, 2016, ARCH IRAN MED, V19, P197, DOI 0161903/AIM.008
   Carling D, 2017, CURR OPIN CELL BIOL, V45, P31, DOI 10.1016/j.ceb.2017.01.005
   Carmi C, 2012, BIOCHEM PHARMACOL, V84, P1388, DOI 10.1016/j.bcp.2012.07.031
   Chen CH, 2010, BIOCHEM BIOPH RES CO, V397, P543, DOI 10.1016/j.bbrc.2010.05.153
   Cheng D, 2018, EXP CELL RES, V368, P101, DOI 10.1016/j.yexcr.2018.04.018
   Choi HW, 2015, MOL MED, V21, P526, DOI 10.2119/molmed.2015.00148
   Chu M, 2018, FRONT PHARMACOL, V9, DOI 10.3389/fphar.2018.00801
   Chu SF, 2016, PHARMACOL THERAPEUT, V162, P179, DOI 10.1016/j.pharmthera.2016.01.002
   Chu Z L, 1994, Zhongguo Zhong Xi Yi Jie He Za Zhi, V14, P510
   Cicero AFG, 2016, ADV EXP MED BIOL, V928, P27, DOI 10.1007/978-3-319-41334-1_2
   Colman RJ, 2014, NAT COMMUN, V5, DOI 10.1038/ncomms4557
   Dong H, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/591654
   Du GH, 2009, WORLD SCI TECHNOL MO, V11, P480
   Du GH, 2016, PHARMACOL THERAPEUT, V162, P23, DOI 10.1016/j.pharmthera.2016.04.008
   Feng R, 2018, FRONT PHARMACOL, V9, DOI 10.3389/fphar.2018.00214
   Feng R, 2015, SCI REP-UK, V5, DOI 10.1038/srep12155
   Gao JM, 2018, FRONT MOL NEUROSCI, V11, DOI 10.3389/fnmol.2018.00267
   Global Burden of Disease Study C, 2015, LANCET, V386, P743, DOI [10.1016/S0140-6736(15)60692-4, DOI 10.1016/S0140-6736(15)60692-4]
   Guo Y, 2016, BMC COMPLEM ALTERN M, V16, DOI 10.1186/s12906-016-1367-7
   Guo Y, 2011, XENOBIOTICA, V41, P996, DOI 10.3109/00498254.2011.597456
   Han JL, 2011, MED SCI MONITOR, V17, pRA164, DOI 10.12659/MSM.881842
   Jeong HW, 2009, AM J PHYSIOL-ENDOC M, V296, pE955, DOI 10.1152/ajpendo.90599.2008
   Jiang J. D., 2018, BEBERINE
   Ju JQ, 2018, PHYTOMEDICINE, V50, P25, DOI 10.1016/j.phymed.2018.09.212
   Kim WS, 2009, AM J PHYSIOL-ENDOC M, V296, pE812, DOI 10.1152/ajpendo.90710.2008
   Kong WJ, 2008, METABOLISM, V57, P1029, DOI 10.1016/j.metabol.2008.01.037
   Kong WJ, 2009, METABOLISM, V58, P109, DOI 10.1016/j.metabol.2008.08.013
   Kong WJ, 2006, J MOL MED, V84, P29, DOI 10.1007/s00109-005-0717-6
   Kong WJ, 2004, NAT MED, V10, P1344, DOI 10.1038/nm1135
   Kumar A, 2015, EUR J PHARMACOL, V761, P288, DOI 10.1016/j.ejphar.2015.05.068
   Kuo FC, 2013, TOXICOL IN VITRO, V27, P1603, DOI 10.1016/j.tiv.2013.04.011
   Lan JR, 2015, J ETHNOPHARMACOL, V161, P69, DOI 10.1016/j.jep.2014.09.049
   Lee YS, 2006, DIABETES, V55, P2256, DOI 10.2337/db06-0006
   Li H, 2009, J BIOL CHEM, V284, P28885, DOI 10.1074/jbc.M109.052407
   Li H, 2009, J LIPID RES, V50, P820, DOI 10.1194/jlr.M800375-JLR200
   Li M, 2016, J TRANSL MED, V14, DOI 10.1186/s12967-016-0987-5
   Li Y, 2011, J TRANSL MED, V9, DOI 10.1186/1479-5876-9-62
   Li Ying, 2016, Zhongguo Zhong Yao Za Zhi, V41, P4066, DOI 10.4268/cjcmm20162128
   Li YH, 2010, BIOORGAN MED CHEM, V18, P6422, DOI 10.1016/j.bmc.2010.06.106
   Li Z, 2014, EVID-BASED COMPL ALT, V2014, DOI 10.1155/2014/289264
   Li Z, 2014, BIOL PHARM BULL, V37, P1766, DOI 10.1248/bpb.b14-00412
   Liang YP, 2019, ENDOCR J, V66, P51, DOI 10.1507/endocrj.EJ18-0109
   Lin Yuan, 2018, Yaoxue Xuebao, V53, P163, DOI 10.16438/j.0513-4870.2017-0816
   Liu D, 2018, EXP CLIN ENDOCR DIAB, V126, P513, DOI 10.1055/s-0043-125066
   Longo VD, 2014, CELL METAB, V19, P181, DOI 10.1016/j.cmet.2013.12.008
   Lu SS, 2009, J ENDOCRINOL, V200, P159, DOI 10.1677/JOE-08-0419
   Mason RP, 2006, J BIOL CHEM, V281, P9337, DOI 10.1074/jbc.M513000200
   McNabney SM, 2017, NUTRIENTS, V9, DOI 10.3390/nu9121348
   Meng S, 2012, CLIN EXP PHARMACOL P, V39, P406, DOI 10.1111/j.1440-1681.2012.05670.x
   Nencioni A, 2018, NAT REV CANCER, V18, P707, DOI 10.1038/s41568-018-0061-0
   Paul M, 2019, FREE RADICAL BIO MED, V130, P196, DOI 10.1016/j.freeradbiomed.2018.10.453
   Pirillo A, 2015, ATHEROSCLEROSIS, V243, P449, DOI 10.1016/j.atherosclerosis.2015.09.032
   Porru E, 2018, ANAL BIOANAL CHEM, V410, P3533, DOI 10.1007/s00216-018-0884-2
   Rizos CV, 2016, ARCH TOXICOL, V90, P1861, DOI 10.1007/s00204-016-1737-4
   Shah RR, 2013, DRUG SAFETY, V36, P491, DOI 10.1007/s40264-013-0048-4
   Shan YQ, 2013, BIOL PHARM BULL, V36, P1562, DOI 10.1248/bpb.b13-00272
   Shan YQ, 2013, METABOLISM, V62, P446, DOI 10.1016/j.metabol.2012.09.009
   Spinozzi S, 2014, J NAT PROD, V77, P766, DOI 10.1021/np400607k
   Srivastava KK, 2015, INDIAN J CLIN BIOCHE, V30, P3, DOI 10.1007/s12291-014-0441-5
   Sukhova GK, 2002, ARTERIOSCL THROM VAS, V22, P1452, DOI 10.1161/01.ATV.0000030360.72503.56
   Sun HL, 2016, OBESITY FACTS, V9, P365, DOI 10.1159/000449507
   Sun H, 2015, OMICS, V19, P186, DOI 10.1089/omi.2014.0112
   Sun YN, 2018, NUTR DIABETES, V8, DOI 10.1038/s41387-018-0061-x
   Szabo G, 2010, DIGEST DIS, V28, P737, DOI 10.1159/000324281
   Tan XS, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0077969
   Umar A, 2016, SEMIN ONCOL, V43, P65, DOI 10.1053/j.seminoncol.2015.09.010
   Wang C, 2018, INT J PHARMACOL, V14, P1087, DOI 10.3923/ijp.2018.1087.1098
   Wang Jiesheng, 2016, Zhejiang Da Xue Xue Bao Yi Xue Ban, V45, P486
   Wang K, 2017, DRUG METAB REV, V49, P139, DOI 10.1080/03602532.2017.1306544
   Wang LL, 2017, J CHROMATOGR B, V1057, P70, DOI 10.1016/j.jchromb.2017.05.004
   Wang X, 2017, SCI REP-UK, V7, DOI 10.1038/srep44040
   Wang Yan, 2018, Yaoxue Xuebao, V53, P659, DOI 10.16438/j.0513-4870.2018-0233
   Wang Y, 2017, THERANOSTICS, V7, P2443, DOI 10.7150/thno.18290
   Wang Y, 2017, METABOLISM, V70, P72, DOI 10.1016/j.metabol.2017.02.003
   Wang YX, 2012, BIOORGAN MED CHEM, V20, P6552, DOI 10.1016/j.bmc.2012.09.029
   Wen HT, 2011, NAT IMMUNOL, V12, P408, DOI 10.1038/ni.2022
   WHO, 2014, GLOBAL STATUS REPORT ON VIOLENCE PREVENTION 2014, P1
   Wilkinson EM, 2018, MATURITAS, V112, P53, DOI 10.1016/j.maturitas.2018.03.012
   Wu J. F., 1995, Yaoxue Xuebao, V30, P98
   Wu L. Y., 2017, CHINA PRACTICAL MED, V12, P128
   Wu M, 2010, CHIN J INTEGR MED, V16, P188, DOI 10.1007/s11655-010-0188-7
   Xia L. M., 2016, CHRONIC DIS TRANSLAT, V1, P231
   Xie FY, 2017, ENDOCR J, V64, P685, DOI 10.1507/endocrj.EJ17-0012
   Xu M, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0103702
   Yan HM, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0134172
   Yao J, 2015, SCI CHINA LIFE SCI, V58, P854, DOI 10.1007/s11427-013-4568-z
   Yin J, 2008, AM J PHYSIOL-ENDOC M, V294, pE148, DOI 10.1152/ajpendo.00211.2007
   Yu XT, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0194069
   Zhang H, 2010, MOL CELL ENDOCRINOL, V330, P25, DOI 10.1016/j.mce.2010.07.022
   Zhang H, 2010, METABOLISM, V59, P285, DOI 10.1016/j.metabol.2009.07.029
   Zhang LC, 2017, EXP THER MED, V13, P3374, DOI 10.3892/etm.2017.4402
   Zhang X, 2012, PLOS ONE, V7, DOI [10.1371/journal.pone.0042529, 10.1371/journal.pone.0035700]
   Zhang XQ, 2015, SCI REP-UK, V5, DOI 10.1038/srep10737
   Zhang Yan-ling, 2019, Chinese Pharmacological Bulletin, V35, P1664, DOI 10.3969/j.issn.1001-1978.2019.12.009
   Zhang Y, 2017, SCI CHINA LIFE SCI, V60, P601, DOI 10.1007/s11427-017-9047-4
   Zhao W, 2008, BIOMED PHARMACOTHER, V62, P730, DOI 10.1016/j.biopha.2008.01.007
   Zhou H, 2017, BIOMED PHARMACOTHER, V89, P864, DOI 10.1016/j.biopha.2017.03.003
   Zhou Y, 2014, FITOTERAPIA, V92, P230, DOI 10.1016/j.fitote.2013.11.010
   Zhu L, 2018, ATHEROSCLEROSIS, V268, P117, DOI 10.1016/j.atherosclerosis.2017.11.023
   Zhu XP, 2016, MOLECULES, V21, DOI 10.3390/molecules21101336
NR 106
TC 43
Z9 48
U1 2
U2 32
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0163-7258
EI 1879-016X
J9 PHARMACOL THERAPEUT
JI Pharmacol. Ther.
PD MAY
PY 2020
VL 209
AR 107496
DI 10.1016/j.pharmthera.2020.107496
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA LG7AJ
UT WOS:000528248800003
PM 32001311
DA 2023-06-08
ER

PT J
AU Deng, L
   Yang, Y
   Xu, GS
AF Deng, Le
   Yang, Yang
   Xu, Gaosi
TI Empagliflozin ameliorates type 2 diabetes mellitus-related diabetic
   nephropathy via altering the gut microbiota
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
LA English
DT Article
DE Empagliflozin; Diabetic nephropathy; Gut microbiota; 16S rRNA sequencing
ID METFORMIN
AB Background: The dysregulation of gut microbiota can be found in patients with type 2 diabetes mellitus (T2DM)-related diabetic nephropathy (DN). Inhibitors of sodium-glucose co-transporter 2 (SGLT2) were reported to affect gut microbiota. This study aimed to identify whether empagliflozin (EMPA) attenuated DN via regulating gut microbiota.Materials and methods: The high-fat diet (HFD) combining streptozocin (STZ) injection was performed to induce DN in mice. The therapeutic effects of EMPA were observed by staining of renal tissues and urine albumin/ creatinine ratio (UACR). Mouse feces were collected for 16S rRNA sequencing. Fecal short-chain fatty acids (SCFAs) and fecal and serum lipopolysaccharide (LPS) were determined. An antibiotic-ablated model was established to confirm the role of the gut microbiota in the actions of EMPA.Results: EMPA reduced the elevation of blood glucose and UACR caused by HFD/STZ. It inhibited the thickening of the colonic crypt and restored goblet cells and the expressions of ZO-1 and Occludin. The 16S rRNA sequencing showed that the diversity of gut microbiota was reduced after HFD/STZ treatment, while it was restored after EMPA treatment. The LPS-producing bacteria, Oscillibacter, and the SCFA-producing bacteria, Bateroid and Odoribacter, were changed after EMPA administration. The therapeutic effects of EMPA on ABX-treated mice were reduced. Meanwhile, the level of fecal SCFAs was decreased, while the levels of fecal and serum LPS were elevated, in T2DM mice, and they were negated by the administration of EMPA.Conclusion: EMPA ameliorates T2DM-related DN via altering the gut microbiota, especially reducing LPS-producing bacteria and increasing SCFA-producing bacteria.
C1 [Deng, Le; Yang, Yang; Xu, Gaosi] Nanchang Univ, Affiliated Hosp 2, Dept Nephrol, Nanchang 330006, Jiangxi, Peoples R China.
   [Xu, Gaosi] Nanchang Univ, Affiliated Hosp 2, Dept Nephrol, 1 Minde Rd, Nanchang 330006, Peoples R China.
C3 Nanchang University; Nanchang University
RP Xu, GS (通讯作者)，Nanchang Univ, Affiliated Hosp 2, Dept Nephrol, 1 Minde Rd, Nanchang 330006, Peoples R China.
EM sixugao0@163.com
FU National Natural Science Foundation of China [81970583, 82060138];
   Nature Science Foundation of Jiangxi Province [2020BABL206025]; Projects
   in the Second Affiliated Hospital of Nanchang University [2019YNLZ12008]
FX This work was supported by the National Natural Science Foundation of
   China (No. 81970583 and No. 82060138), the Nature Science Foundation of
   Jiangxi Province (No. 2020BABL206025), and the Projects in the Second
   Affiliated Hospital of Nanchang University (No. 2019YNLZ12008).
CR Allin KH, 2015, EUR J ENDOCRINOL, V172, pR167, DOI 10.1530/EJE-14-0874
   Aroor AR, 2018, CARDIOVASC DIABETOL, V17, DOI 10.1186/s12933-018-0750-8
   Astiarraga B, 2020, DIABETES CARE, V43, P2581, DOI 10.2337/dc20-0460
   Carvalho AL, 2018, J CELL PHYSIOL, V233, P1585, DOI 10.1002/jcp.26062
   Cheng Y, 2019, DIABETOLOGIA, V62, P1074, DOI 10.1007/s00125-019-4838-9
   Cosentino F., 2020, EUR HEART J, V41, P255, DOI [DOI 10.1093/eurheartj/ehz486, DOI 10.1093/EURHEARTJ/EHZ486]
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Delaney KZ, 2022, OBES REV, V23, DOI 10.1111/obr.13393
   Ding LN, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.770861
   Ding YY, 2021, FOOD CHEM TOXICOL, V149, DOI 10.1016/j.fct.2021.112003
   Duan CY, 2020, AGING-US, V12, P1397, DOI 10.18632/aging.102690
   Fremder M, 2021, CELL REP, V36, DOI 10.1016/j.celrep.2021.109521
   Herat LY, 2020, WORLD J GASTROENTERO, V26, DOI 10.3748/wjg.v26.i23.3225
   Herat LY, 2020, JACC-BASIC TRANSL SC, V5, P169, DOI 10.1016/j.jacbts.2019.11.007
   Jiang S, 2021, REDOX BIOL, V46, DOI 10.1016/j.redox.2021.102115
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Korbut AI, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21082987
   Le KA, 2013, FRONT PHYSIOL, V3, DOI 10.3389/fphys.2012.00496
   Lee DM, 2018, CARDIOVASC DIABETOL, V17, DOI 10.1186/s12933-018-0708-x
   Lee YS, 2022, EUR REV MED PHARMACO, V26, P2794, DOI 10.26355/eurrev_202204_28610
   Lee YS, 2021, FOOD FUNCT, V12, P6363, DOI [10.1039/d1fo00698c, 10.1039/D1FO00698C]
   Leguina-Ruzzi A, 2018, BIOMED J, V41, P328, DOI 10.1016/j.bj.2018.08.005
   Lertpatipanpong P, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-94581-y
   Li YJ, 2020, J AM SOC NEPHROL, V31, P1267, DOI 10.1681/ASN.2019101029
   Lindfors S, 2021, DIABETOLOGIA, V64, P1866, DOI 10.1007/s00125-021-05473-9
   Liu Q, 2020, MICROB CELL FACT, V19, DOI 10.1186/s12934-020-1289-4
   Merovci A, 2014, J CLIN INVEST, V124, P509, DOI 10.1172/JCI70704
   Mosterd CM, 2021, BEST PRACT RES CL EN, V35, DOI 10.1016/j.beem.2021.101484
   Napolitano A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100778
   Qiang S, 2015, DIABETOL METAB SYNDR, V7, DOI 10.1186/s13098-015-0102-8
   Salamon D, 2018, POL ARCH INTERN MED, V128, P336, DOI 10.20452/pamw.4246
   Scheen AJ, 2020, NAT REV ENDOCRINOL, V16, P556, DOI 10.1038/s41574-020-0392-2
   Smith EA, 1997, ANAEROBE, V3, P327, DOI 10.1006/anae.1997.0121
   Song JJ, 2017, BRIT J NUTR, V118, P481, DOI [10.1017/S0007114517002380, 10.1017/s0007114517002380]
   Subba R, 2022, EUR J PHARMACOL, V925, DOI 10.1016/j.ejphar.2022.174993
   Sun YG, 2021, FOOD CHEM TOXICOL, V156, DOI 10.1016/j.fct.2021.112522
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Wu SY, 2021, FOOD RES INT, V147, DOI 10.1016/j.foodres.2021.110550
   Yang M, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.00635
   Yuan QC, 2020, NUTRIENTS, V12, DOI 10.3390/nu12010220
   Zhang BX, 2022, FRONT CELL INFECT MI, V12, DOI 10.3389/fcimb.2022.855075
   Zhang HH, 2002, DIABETES, V51, P2929, DOI 10.2337/diabetes.51.10.2929
   Zhang XY, 2020, GUT MICROBES, V12, DOI 10.1080/19490976.2020.1842990
NR 43
TC 6
Z9 6
U1 19
U2 25
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1388-1981
EI 1879-2618
J9 BBA-MOL CELL BIOL L
JI Biochim. Biophys. Acta Mol. Cell Biol. Lipids
PD DEC
PY 2022
VL 1867
IS 12
AR 159234
DI 10.1016/j.bbalip.2022.159234
PG 11
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA 5H4GK
UT WOS:000867638500001
PM 36185030
DA 2023-06-08
ER

PT J
AU Tanner, JE
   Alfieri, C
AF Tanner, Jerome E.
   Alfieri, Caroline
TI The Fatty Acid Lipid Metabolism Nexus in COVID-19
SO VIRUSES-BASEL
LA English
DT Review
DE endoplasmic reticulum stress response; unfolded protein response;
   mTORC1; SREBP-1; nonstructural protein; membrane protein; spike protein;
   envelope protein; replicative organelle; antiviral
ID ACUTE-RESPIRATORY-SYNDROME; ENDOPLASMIC-RETICULUM STRESS;
   UNFOLDED-PROTEIN-RESPONSE; ANGIOTENSIN-CONVERTING ENZYME;
   NECROSIS-FACTOR-ALPHA; VIRUS-REPLICATION; SARS-CORONAVIRUS; GUT
   MICROBIOTA; SPIKE GLYCOPROTEIN; MAINTAINS ENERGY
AB Enteric symptomology seen in early-stage severe acute respiratory syndrome (SARS)-2003 and COVID-19 is evidence of virus replication occurring in the intestine, liver and pancreas. Aberrant lipid metabolism in morbidly obese individuals adversely affects the COVID-19 immune response and increases disease severity. Such observations are in line with the importance of lipid metabolism in COVID-19, and point to the gut as a site for intervention as well as a therapeutic target in treating the disease. Formation of complex lipid membranes and palmitoylation of coronavirus proteins are essential during viral replication and assembly. Inhibition of fatty acid synthase (FASN) and restoration of lipid catabolism by activation of AMP-activated protein kinase (AMPK) impede replication of coronaviruses closely related to SARS-coronavirus-2 (CoV-2). In vitro findings and clinical data reveal that the FASN inhibitor, orlistat, and the AMPK activator, metformin, may inhibit coronavirus replication and reduce systemic inflammation to restore immune homeostasis. Such observations, along with the known mechanisms of action for these types of drugs, suggest that targeting fatty acid lipid metabolism could directly inhibit virus replication while positively impacting the patient's response to COVID-19.
C1 [Tanner, Jerome E.; Alfieri, Caroline] CHU Sainte Justine, Res Ctr, Lab Viral Pathogenesis, 3175 Cote Sainte Catherine Rd, Montreal, PQ H3T 1C5, Canada.
   [Alfieri, Caroline] Univ Montreal, Dept Microbiol Infectiol & Immunol, 2900 Boul Edouard Montpetit, Montreal, PQ H3T 1J4, Canada.
C3 Universite de Montreal; Universite de Montreal
RP Alfieri, C (通讯作者)，CHU Sainte Justine, Res Ctr, Lab Viral Pathogenesis, 3175 Cote Sainte Catherine Rd, Montreal, PQ H3T 1C5, Canada.; Alfieri, C (通讯作者)，Univ Montreal, Dept Microbiol Infectiol & Immunol, 2900 Boul Edouard Montpetit, Montreal, PQ H3T 1J4, Canada.
EM jerome.tanner.hsj@ssss.gouv.qc.ca; carolina.alfieri@umontreal.ca
CR Abou-El-Naga IF, 2019, MED MYCOL, V57, P181, DOI 10.1093/mmy/myy005
   Altan-Bonnett N, 2017, TRENDS CELL BIOL, V27, P201, DOI 10.1016/j.tcb.2016.09.011
   Ammer E, 2015, MED MICROBIOL IMMUN, V204, P635, DOI 10.1007/s00430-015-0391-4
   Angelini MM, 2013, MBIO, V4, DOI 10.1128/mBio.00524-13
   [Anonymous], 1995, CORONAVIRIDAE
   Appelberg S, 2020, EMERG MICROBES INFEC, V9, P1748, DOI 10.1080/22221751.2020.1799723
   Bakhache W, 2019, ANTIVIR RES, V172, DOI 10.1016/j.antiviral.2019.104642
   Beilstein F, 2017, GUT, V66, P2160, DOI 10.1136/gutjnl-2016-311508
   Blanchet M, 2016, ANTIVIR RES, V128, P43, DOI 10.1016/j.antiviral.2016.02.006
   Booth CM, 2003, JAMA-J AM MED ASSOC, V289, P2801, DOI 10.1001/jama.289.21.JOC30885
   Bornstein SR, 2020, NAT REV ENDOCRINOL, V16, P297, DOI 10.1038/s41574-020-0353-9
   Boroughs LK, 2015, NAT CELL BIOL, V17, P351, DOI 10.1038/ncb3124
   Boscarino JA, 2008, J VIROL, V82, P2989, DOI 10.1128/JVI.01906-07
   Brandt A, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-43228-0
   Bravo R, 2013, INT REV CEL MOL BIO, V301, P215, DOI 10.1016/B978-0-12-407704-1.00005-1
   Browne CD, 2006, FASEB J, V20, P2027, DOI 10.1096/fj.05-5404com
   Calixto MC, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0076786
   Cameron KO, 2016, BIOORG MED CHEM LETT, V26, P5139, DOI 10.1016/j.bmcl.2016.09.065
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Chamberlain LH, 2015, PHYSIOL REV, V95, P341, DOI 10.1152/physrev.00032.2014
   Charakida M, 2013, CURR OPIN CARDIOL, V28, P584, DOI 10.1097/HCO.0b013e3283642a4c
   Chau TN, 2004, HEPATOLOGY, V39, P302, DOI 10.1002/hep.20111
   Chen G, 2020, J CLIN INVEST, V130, P2620, DOI 10.1172/JCI137244
   Cnop M, 2010, DIABETES OBES METAB, V12, P76, DOI 10.1111/j.1463-1326.2010.01279.x
   Cottam EM, 2011, AUTOPHAGY, V7, P1335, DOI 10.4161/auto.7.11.16642
   Davidson S, 2018, FRONT IMMUNOL, V9, DOI 10.3389/fimmu.2018.01946
   de Wilde AH, 2018, CURR TOP MICROBIOL, V419, P1, DOI 10.1007/82_2017_25
   del Campo JA, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0191805
   Dong QM, 2020, MOL CELL BIOCHEM, V463, P13, DOI 10.1007/s11010-019-03625-5
   Dorotea D, 2020, FRONT PHARMACOL, V11, DOI 10.3389/fphar.2020.00265
   Duan W, 2019, AM J TRANSL RES, V11, P2393
   Dunlop EA, 2013, BIOCHEM SOC T, V41, P939, DOI 10.1042/BST20130030
   Eberle D, 2004, BIOCHIMIE, V86, P839, DOI 10.1016/j.biochi.2004.09.018
   Esser K, 2018, ANTIVIR RES, V151, P4, DOI 10.1016/j.antiviral.2018.01.001
   Filippatos TD, 2008, DRUG SAFETY, V31, P53, DOI 10.2165/00002018-200831010-00005
   Foretz M, 2014, CELL METAB, V20, P953, DOI 10.1016/j.cmet.2014.09.018
   Genoni G, 2014, EUR J PEDIATR, V173, P25, DOI 10.1007/s00431-013-2178-1
   Gong Y, 2006, CELL METAB, V3, P15, DOI 10.1016/j.cmet.2005.11.014
   Guerciolini R, 1997, INT J OBESITY, V21, pS12
   Gurung M, 2020, EBIOMEDICINE, V51, DOI 10.1016/j.ebiom.2019.11.051
   Haga S, 2008, P NATL ACAD SCI USA, V105, P7809, DOI 10.1073/pnas.0711241105
   Han CQ, 2020, AM J GASTROENTEROL, V115, P916, DOI 10.14309/ajg.0000000000000664
   Han YM, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-08585-4
   Hansen SG, 1999, VIROLOGY, V254, P124, DOI 10.1006/viro.1998.9543
   Hardie DG, 2012, NAT REV MOL CELL BIO, V13, P251, DOI 10.1038/nrm3311
   Hetz C, 2018, MOL CELL, V69, P169, DOI 10.1016/j.molcel.2017.06.017
   Hitakarun A, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-58468-8
   Holshue ML, 2020, NEW ENGL J MED, V382, P929, DOI 10.1056/NEJMoa2001191
   Jeffers SA, 2004, P NATL ACAD SCI USA, V101, P15748, DOI 10.1073/pnas.0403812101
   Jensen MD, 2014, J AM COLL CARDIOL, V63, P2985, DOI 10.1016/j.jacc.2013.11.004
   Jiang HZ, 2019, CURR MED CHEM, V26, P7081, DOI 10.2174/0929867326666190507105022
   Jin X, 2020, GUT, V69, P1002, DOI 10.1136/gutjnl-2020-320926
   Jones SF, 2015, CLIN CANCER RES, V21, P5434, DOI 10.1158/1078-0432.CCR-15-0126
   Kahn BB, 2005, CELL METAB, V1, P15, DOI 10.1016/j.cmet.2004.12.003
   Karagoz GE, 2019, CSH PERSPECT BIOL, V11, DOI 10.1101/cshperspect.a033886
   Kindrachuk J, 2015, ANTIMICROB AGENTS CH, V59, P1088, DOI 10.1128/AAC.03659-14
   Knoops K, 2008, PLOS BIOL, V6, P1957, DOI 10.1371/journal.pbio.0060226
   Koh SJ, 2014, J GASTROEN HEPATOL, V29, P502, DOI 10.1111/jgh.12435
   Krogh A, 2001, J MOL BIOL, V305, P567, DOI 10.1006/jmbi.2000.4315
   Kuba K, 2005, NAT MED, V11, P875, DOI 10.1038/nm1267
   Kuo L, 2016, J VIROL, V90, P4357, DOI 10.1128/JVI.03212-15
   Lalau JD, 2021, DIABETES METAB, V47, DOI 10.1016/j.diabet.2020.101216
   Lambert DW, 2005, J BIOL CHEM, V280, P30113, DOI 10.1074/jbc.M505111200
   Laplante M, 2009, CURR BIOL, V19, pR1046, DOI 10.1016/j.cub.2009.09.058
   Lee SY, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0135858
   Li CY, 2016, RESPIROLOGY, V21, P1210, DOI 10.1111/resp.12818
   Li SS, 2015, CRIT REV MICROBIOL, V41, P150, DOI 10.3109/1040841X.2013.813899
   Li Y, 2011, CELL METAB, V13, P376, DOI 10.1016/j.cmet.2011.03.009
   Liang F, 2018, CELL PHYSIOL BIOCHEM, V51, P1276, DOI 10.1159/000495539
   Liao Y, 2006, VIROLOGY, V349, P264, DOI 10.1016/j.virol.2006.01.028
   Lim Yvonne Xinyi, 2016, Diseases, V4, DOI 10.3390/diseases4030026
   Lin L, 2020, GUT, V69, P997, DOI 10.1136/gutjnl-2020-321013
   Liu P, 2020, PLOS PATHOG, V16, DOI 10.1371/journal.ppat.1008421
   Lopez LA, 2008, J VIROL, V82, P3000, DOI 10.1128/JVI.01914-07
   Loscalzo J., 2015, HARRISONS PRINCIPLE, VVolume 2, p417E
   Lu M, 2014, SCIENCE, V345, P98, DOI 10.1126/science.1254312
   Nieva JL, 2012, NAT REV MICROBIOL, V10, P563, DOI 10.1038/nrmicro2820
   Luo P, 2020, AM J TROP MED HYG, V103, P69, DOI 10.4269/ajtmh.20-0375
   Ma EH, 2017, CURR OPIN IMMUNOL, V46, P45, DOI 10.1016/j.coi.2017.04.004
   Mancuso P, 2013, PULM PHARMACOL THER, V26, P412, DOI 10.1016/j.pupt.2012.04.006
   Mascitelli L, 2012, EUR J CLIN PHARMACOL, V68, P889, DOI 10.1007/s00228-011-1190-5
   McBride CE, 2010, VIROLOGY, V405, P139, DOI 10.1016/j.virol.2010.05.031
   Milazzo L, 2009, J VIRAL HEPATITIS, V16, P479, DOI 10.1111/j.1365-2893.2009.01104.x
   Morris M, 2012, OBESITY FACTS, V5, P485, DOI 10.1159/000341589
   Navina S, 2011, SCI TRANSL MED, V3, DOI 10.1126/scitranslmed.3002573
   Neuman BW, 2016, ADV VIRUS RES, V96, P1, DOI 10.1016/bs.aivir.2016.08.005
   Neuman BW, 2014, TRENDS MICROBIOL, V22, P642, DOI 10.1016/j.tim.2014.06.003
   Ning WS, 2021, BRIEF BIOINFORM, V22, P1836, DOI 10.1093/bib/bbaa038
   O'Neill LAJ, 2013, NATURE, V493, P346, DOI 10.1038/nature11862
   Ooi C., 2004, IMAGING SARS, P1
   Ouyang J, 2020, AIDS RES THER, V17, DOI 10.1186/s12981-020-00267-2
   Park CS, 2012, BIOCHEM PHARMACOL, V84, P1660, DOI 10.1016/j.bcp.2012.09.025
   Pemble CW, 2007, NAT STRUCT MOL BIOL, V14, P704, DOI 10.1038/nsmb1265
   Peterson TR, 2011, CELL, V146, P408, DOI 10.1016/j.cell.2011.06.034
   Petit CM, 2007, VIROLOGY, V360, P264, DOI 10.1016/j.virol.2006.10.034
   Petrilli CM, 2020, BMJ-BRIT MED J, V369, DOI [10.1136/bmj.m1966, 10.12890/2020_001747]
   Pollak M, 2017, DIABETOLOGIA, V60, P1662, DOI 10.1007/s00125-017-4352-x
   Rana MS, 2019, BIOCHEM SOC T, V47, P157, DOI 10.1042/BST20180429
   Ren J, 2008, PROTEIN ENG DES SEL, V21, P639, DOI 10.1093/protein/gzn039
   Resh MD, 2016, PROG LIPID RES, V63, P120, DOI 10.1016/j.plipres.2016.05.002
   Ruch TR, 2012, VIRUSES-BASEL, V4, P363, DOI 10.3390/v4030363
   Samuelsson L, 2003, DIABETES OBES METAB, V5, P195, DOI 10.1046/j.1463-1326.2003.00264.x
   Schoeman D, 2019, VIROL J, V16, DOI 10.1186/s12985-019-1182-0
   Shimomura I, 1999, J BIOL CHEM, V274, P30028, DOI 10.1074/jbc.274.42.30028
   Siebenhofer A, 2013, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD007654.pub3
   Sievers F, 2011, MOL SYST BIOL, V7, DOI 10.1038/msb.2011.75
   Singh S, 2020, J IMMUNOL, V204, P1810, DOI 10.4049/jimmunol.1901310
   Sodhi CP, 2018, AM J PHYSIOL-LUNG C, V314, pL17, DOI 10.1152/ajplung.00498.2016
   Song Y, 2020, GUT, V69, P1143, DOI 10.1136/gutjnl-2020-320891
   Sprooten J, 2020, INT REV CEL MOL BIO, V350, P63, DOI 10.1016/bs.ircmb.2019.10.004
   Stapleford KA, 2010, VIRUSES-BASEL, V2, P1055, DOI 10.3390/v2051055
   STOCKER W, 1995, PROTEIN SCI, V4, P823
   Subir R, 2020, DIABETES METAB SYND, V14, P1225, DOI 10.1016/j.dsx.2020.07.011
   Tabas I, 2011, NAT CELL BIOL, V13, P184, DOI 10.1038/ncb0311-184
   Tanaka S, 2009, DIABETES, V58, P2285, DOI 10.2337/db09-0091
   Thorp EB, 2006, J VIROL, V80, P1280, DOI 10.1128/JVI.80.3.1280-1289.2006
   Tipnis SR, 2000, J BIOL CHEM, V275, P33238, DOI 10.1074/jbc.M002615200
   Tongluan N, 2017, VIROL J, V14, DOI 10.1186/s12985-017-0685-9
   Trujillo ME, 2006, ENDOCR REV, V27, P798, DOI 10.1210/er.2006-0033
   Tsai WL, 2017, ONCOTARGET, V8, P91928, DOI 10.18632/oncotarget.20248
   Ursini F, 2020, DIABETES RES CLIN PR, V164, DOI 10.1016/j.diabres.2020.108167
   Ursini F, 2018, FRONT IMMUNOL, V9, DOI 10.3389/fimmu.2018.01236
   Vankadari N, 2020, EMERG MICROBES INFEC, V9, P601, DOI 10.1080/22221751.2020.1739565
   Veit M, 2012, BIOL CELL, V104, P493, DOI 10.1111/boc.201200006
   Venkatagopalan P, 2015, VIROLOGY, V478, P75, DOI 10.1016/j.virol.2015.02.005
   Verheije MH, 2008, PLOS PATHOG, V4, DOI 10.1371/journal.ppat.1000088
   Verpaalen B, 2014, ANTIVIR RES, V105, P92, DOI 10.1016/j.antiviral.2014.02.020
   Victor VM, 2015, ATHEROSCLEROSIS, V242, P167, DOI 10.1016/j.atherosclerosis.2015.07.017
   Wang B, 2019, ANNU REV PHYSIOL, V81, P165, DOI 10.1146/annurev-physiol-020518-114444
   Wang B, 2018, NAT REV ENDOCRINOL, V14, P452, DOI 10.1038/s41574-018-0037-x
   Ward NC, 2019, CIRC RES, V124, P328, DOI 10.1161/CIRCRESAHA.118.312782
   Wurtzer S, 2020, EUROSURVEILLANCE, V25, P38, DOI 10.2807/1560-7917.ES.2020.25.50.2000776
   Xie W, 2015, J MOL CELL CARDIOL, V85, P155, DOI 10.1016/j.yjmcc.2015.05.021
   Xun YH, 2014, J VIRAL HEPATITIS, V21, P597, DOI 10.1111/jvh.12187
   Yabe D, 2002, P NATL ACAD SCI USA, V99, P16672, DOI 10.1073/pnas.262669399
   Yan BP, 2019, VIRUSES-BASEL, V11, DOI 10.3390/v11010073
   Yang JK, 2010, ACTA DIABETOL, V47, P193, DOI 10.1007/s00592-009-0109-4
   Yang W, 2008, HEPATOLOGY, V48, P1396, DOI 10.1002/hep.22508
   Yang X, 2020, LANCET RESP MED, V8, pE26
   Yanovski SZ, 2014, JAMA-J AM MED ASSOC, V311, P74, DOI 10.1001/jama.2013.281361
   Yellaturu CR, 2009, J BIOL CHEM, V284, P31726, DOI 10.1074/jbc.M109.050914
   Yiu JHC, 2017, J MOL MED, V95, P13, DOI 10.1007/s00109-016-1474-4
   Zhang CS, 2016, CELL METAB, V24, P521, DOI 10.1016/j.cmet.2016.09.003
   Zhang J, 2018, AM J RESP CRIT CARE, V198, P509, DOI 10.1164/rccm.201712-2570OC
   Zhang JZ, 2003, WORLD J GASTROENTERO, V9, P1135, DOI 10.3748/wjg.v9.i6.1135
   Zhao T, 2021, DIABETES METAB SYND, V15, P21, DOI 10.1016/j.dsx.2020.11.017
   Zhi JG, 1999, J CLIN PHARMACOL, V39, P41, DOI 10.1177/00912709922007543
   ZHOU P, 2020, NATURE, V579, P270, DOI DOI 10.1038/s41586-020-2012-7
   Zhu LH, 2020, CELL METAB, V31, P1068, DOI 10.1016/j.cmet.2020.04.021
NR 149
TC 39
Z9 40
U1 3
U2 30
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1999-4915
J9 VIRUSES-BASEL
JI Viruses-Basel
PD JAN
PY 2021
VL 13
IS 1
AR 90
DI 10.3390/v13010090
PG 18
WC Virology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Virology
GA PW6WM
UT WOS:000610812400001
PM 33440724
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Yan, XM
   Zhang, YL
   Peng, Y
   Li, XB
AF Yan, Xiumei
   Zhang, Yulong
   Peng, Ying
   Li, Xiaobo
TI The water extract of Radix scutellariae, its total flavonoids and
   baicalin inhibited CYP7A1 expression, improved bile acid, and glycolipid
   metabolism in T2DM mice
SO JOURNAL OF ETHNOPHARMACOLOGY
LA English
DT Article
DE Radix scutellariae; Total flavonoids; Baicalin; Type 2 diabetes
   mellitus; Bile acids
ID INSULIN-RESISTANCE; SKELETAL-MUSCLE; INFLAMMATION; METFORMIN; PATHWAY;
   CELLS; LIVER
AB Ethnopharmacological relevance: Radix scutellariae (the root of Scutellaria baicalensis Georgi), is a traditional Chinese medicine (TCM) used to treat type 2 diabetes mellitus (T2DM). Abundant flavonoids are the antidiabetic components of Radix scutellariae, of which baicalin (Baicalein 7-O-glucuronide, BG) is the major bioactive component. Our previous studies found that the water extract of Radix scutellariae (WESB) could exert hypoglycemic and hypolipidemic efficacies by adjusting the ileum FXR-medicated interaction between gut microbiota and bile acid (BA) metabolism. However, it remains unclear whether WESB and its biologically active ingredients exert an antidiabetic effect through bile acid signaling mediated by FXR-CYP7A1. Aims of the study: To explore the mechanism of WESB and its total flavonoids (TF) further and BG on BA signals and glycolipid metabolism in T2DM mice. Materials and methods: The antidiabetic effects of WESB, TF and BG were evaluated by indexing the body weight, fasting blood glucose (FBG) and oral glucose tolerance test (OGTT) in HFD/STZ-induced (high-fat diet and streptozocin) diabetic mice, and comparing them with the positive control (metformin). The lipids in the mouse liver and the total bile acids (TBA) in the mouse liver and bile were detected by commercial kits. The concentration of BAs in the mouse feces was determined by liquid chromatography-tandem mass spectrometry. The protein expression levels of cholesterol 7 alpha-hydroxylase (CYP7A1), farnesol X receptor (FXR), etc., in the liver and/or ileum, play a key role in the BAs metabolism of T2DM mice were evaluated by immunoblot analysis. Results: The hyperglycemia and impaired glucose tolerance of T2DM mice were improved after WESB, TF and BG treatment. Especially after BG administration, the levels of low-density lipoprotein-cholesterol (LDL-c) and total glyceride (TG) in the T2DM mouse liver were significantly decreased (p < 0.05). While the level of high-density lipoprotein cholesterol (HDL-c) was significant increased (p < 0.001). Meanwhile, the levels of TBA in both the liver and bile of T2DM mice were significantly decreased by BG (p < 0.05). Moreover, the high expression of CYP7A1 in the liver of T2DM mice was significantly inhibited by WESB, TF and BG (p < 0.05), and the high expression of FXR in the ileum of T2DM mice was significantly inhibited by TF (p < 0.05). Conclusion: These results indicated that the hypoglycemic effects of WESB, TF and BG might be exerted by inhibiting the expression of CYP7A1 in T2DM mice, and TF inhibited expression of intestinal FXR by inducing changes in fecal BA profile. BG significantly improved hepatic lipid metabolism. Moreover, BG reduced lipid accumulation in the liver and bile by inhibiting the expression of CYP7A1 in T2DM mice. These findings provide useful explanations for the antidiabetic mechanism of Radix scutellariae.
C1 [Yan, Xiumei; Zhang, Yulong; Peng, Ying; Li, Xiaobo] Shanghai Jiao Tong Univ, Sch Pharm, 800 Dongchuan Rd, Shanghai 200240, Peoples R China.
C3 Shanghai Jiao Tong University
RP Li, XB (通讯作者)，Shanghai Jiao Tong Univ, Sch Pharm, 800 Dongchuan Rd, Shanghai 200240, Peoples R China.
EM xbli@sjtu.edu.cn
OI Li, Xiaobo/0000-0002-7500-9275; Peng, Ying/0000-0003-2419-0702
CR Ameer F, 2014, METABOLISM, V63, P895, DOI 10.1016/j.metabol.2014.04.003
   ARAJO TG, 2016, J ETHNOPHARMACOL, V183, DOI DOI 10.1016/J.JEP.2016.02.048
   Chae Byeong Suk, 2013, Natural Product Sciences, V19, P316
   Chiang JYL, 2013, COMPR PHYSIOL, V3, P1191, DOI 10.1002/cphy.c120023
   Claudel T, 2003, GASTROENTEROLOGY, V125, P544, DOI 10.1016/S0016-5085(03)00896-5
   Cui L, 2019, INT J BIOL MACROMOL, V132, P393, DOI 10.1016/j.ijbiomac.2019.03.230
   Cui X, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19113634
   Dai JY, 2018, P NATL ACAD SCI USA, V115, pE5896, DOI 10.1073/pnas.1801745115
   Deng T, 2008, PHARM BIOL, V46, P610, DOI 10.1080/13880200802179584
   Fang PH, 2020, PHARMACOL REP, V72, P13, DOI 10.1007/s43440-019-00024-x
   Ferrell JM, 2016, J LIPID RES, V57, P1144, DOI 10.1194/jlr.M064709
   Goodwin B, 2000, MOL CELL, V6, P517, DOI 10.1016/S1097-2765(00)00051-4
   Han K, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0182467
   Hang YX, 2018, LIPIDS HEALTH DIS, V17, DOI 10.1186/s12944-018-0797-2
   Ji GY, 2011, LIPIDS HEALTH DIS, V10, DOI 10.1186/1476-511X-10-23
   Jia W, 2018, NAT REV GASTRO HEPAT, V15, P111, DOI 10.1038/nrgastro.2017.119
   John C, 2014, J CHROMATOGR A, V1371, P184, DOI 10.1016/j.chroma.2014.10.064
   Ju MZ, 2019, EUR J PHARMACOL, V857, DOI 10.1016/j.ejphar.2019.172457
   Lei Z., 2016, J BEIJING UNIV TRADI, V39, P769, DOI [10.3969/j.issn.1006-2157.2016.09.014,09, DOI 10.3969/J.ISSN.1006-2157.2016.09.014,09]
   Li TG, 2012, J BIOL CHEM, V287, P1861, DOI 10.1074/jbc.M111.305789
   Li Y., 2007, J HEIBEI TCM PHARM, V22, P36, DOI [10.16370/j.cnki.13-1214/r.2007.01.018, DOI 10.16370/J.CNKI.13-1214/R.2007.01.018]
   Metlakunta A, 2017, AM J PHYSIOL-ENDOC M, V312, pE11, DOI 10.1152/ajpendo.00250.2016
   Neuschwander-Tetri BA, 2015, LANCET, V385, P956, DOI 10.1016/S0140-6736(14)61933-4
   Oliveira WH, 2016, BRAIN RES, V1644, P149, DOI 10.1016/j.brainres.2016.05.013
   Palanivel R, 2005, FEBS LETT, V579, P5049, DOI 10.1016/j.febslet.2005.08.011
   Rendina-Ruedy E, 2015, J NUTR METAB, V2015, DOI 10.1155/2015/758080
   Somm E, 2018, ENDOCR REV, V39, P960, DOI 10.1210/er.2018-00134
   Song KH, 2013, PHYTOTHER RES, V27, P244, DOI 10.1002/ptr.4691
   SUBBIAH MTR, 1984, BIOCHEM BIOPH RES CO, V124, P896, DOI 10.1016/0006-291X(84)91042-8
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Tian X, 2019, J PHARM PHARMACOL, V71, P788, DOI 10.1111/jphp.13067
   Trabelsi MS, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms8629
   Vincent RP, 2013, ANN CLIN BIOCHEM, V50, P360, DOI 10.1177/0004563212473450
   Waisundara VY, 2008, AM J CHINESE MED, V36, P517, DOI 10.1142/S0192415X08005953
   Waldman B, 2014, DIABETES CARE, V37, P2351, DOI 10.2337/dc13-2738
   Wang T, 2017, EUR J MED CHEM, V141, P92, DOI 10.1016/j.ejmech.2017.09.049
   Wu YJ, 2020, J DIABETES RES, V2020, DOI 10.1155/2020/6138438
   Xi YL, 2016, CHIN J NAT MEDICINES, V14, P48, DOI 10.3724/SP.J.1009.2016.00048
   Xi YL, 2015, CELL PHYSIOL BIOCHEM, V35, P2349, DOI 10.1159/000374037
   Xiao SW, 2020, APPL MICROBIOL BIOT, V104, P303, DOI 10.1007/s00253-019-10174-w
   Xing SH, 2014, J ETHNOPHARMACOL, V152, P183, DOI 10.1016/j.jep.2013.12.056
   Yanai H, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20051190
   Yang MD, 2012, HEPATOLOGY, V55, P1271, DOI 10.1002/hep.24792
   You WJ, 2018, J CELL BIOCHEM, V119, P8547, DOI 10.1002/jcb.27095
   Zechner R, 2005, CURR OPIN LIPIDOL, V16, P333, DOI 10.1097/01.mol.0000169354.20395.1c
   Zhang CL, 2018, CURR MED SCI, V38, P167, DOI 10.1007/s11596-018-1861-x
   Zhang YY, 2017, MAR DRUGS, V15, DOI 10.3390/md15060163
   Zhang YL, 2020, J ETHNOPHARMACOL, V247, DOI 10.1016/j.jep.2019.112273
   Zhao LJ, 2021, PHYTOMEDICINE, V83, DOI 10.1016/j.phymed.2021.153477
   Ziming L., 2012, CHINA MED HERALD, V9, P143, DOI [10.3969/j.issn.1673-7210.2012.10.068, DOI 10.3969/J.ISSN.1673-7210.2012.10.068]
NR 50
TC 4
Z9 5
U1 12
U2 44
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-8741
EI 1872-7573
J9 J ETHNOPHARMACOL
JI J. Ethnopharmacol.
PD JUL 15
PY 2022
VL 293
AR 115238
DI 10.1016/j.jep.2022.115238
EA APR 2022
PG 10
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA 1F1NT
UT WOS:000794942200001
PM 35351576
DA 2023-06-08
ER

PT J
AU Besnard, P
   Christensen, JE
   Bernard, A
   Simoneau-Robin, I
   Collet, X
   Verges, B
   Burcelin, R
AF Besnard, Philippe
   Christensen, Jeffrey E.
   Bernard, Arnaud
   Simoneau-Robin, Isabelle
   Collet, Xavier
   Verges, Bruno
   Burcelin, Remy
TI Identification of an oral microbiota signature associated with an
   impaired orosensory perception of lipids in insulin-resistant patients
SO ACTA DIABETOLOGICA
LA English
DT Article
DE Microbiota; Circumvallate papillae; Taste sensitivity; Lipids; Type 2
   diabetes
ID DIABETES-MELLITUS; GUT MICROBIOTA; SENSITIVITY; ALTERS; FATTY
AB Aims Type 2 diabetes leads to multiple sensory dysfunctions affecting notably the gustatory sensitivity. Although this sensory defect, by impacting food choices, might lead to unhealthy eating behavior, underlying mechanisms remains poorly studied. We have recently reported that the composition of microbiota in contact with circumvallate gustatory papillae might affect the orosensory perception of lipids in lean and normoglycemic obese subjects. This finding has prompted us to explore whether such a phenomenon also occurs in diabetic obese patients. Methods The composition of microbiota surrounding the circumvallate papillae was analyzed in combination with the linoleic acid perception thresholds in male insulin-resistant patients and weight-matched healthy controls.Two complementary comparisons were performed: (1) controlsvsdiabetic and (2) diabetic low-lipid tasters versus diabetic high-lipid tasters. Results Despite subtle modifications in the oral microbiota composition, comparison of orosensory lipid perception in controls and diabetic subjects did not lead to discriminating data due to the large inter-individual variability of linoleic acid perception thresholds. In contrast, specific bacterial signatures were found by comparing diabetic low- and high-lipid tasters leading to differential molecular pathways. Surprisingly, a lower fatty taste perception was mainly found in patients treated with metformin and/or statins, suggesting a possible side effect of these antidiabetic and/or hypolipidemic drugs on taste acuity. Conclusions Collectively, these data show that the diabetic patients with defective fatty taste detection are characterized by a specific microbiota metabolism at the circumvallate papillae levels, this occurrence seeming amplified by drugs commonly used to counteract the damaging metabolic effects of T2D. Trial registration for original previous studies: ClinicalTrials.gov #NCT02028975
C1 [Besnard, Philippe; Bernard, Arnaud; Simoneau-Robin, Isabelle; Verges, Bruno] Univ Bourgogne Franche Comte, UMR Lipides Nutr Canc 1231, INSERM, AgroSup Dijon, F-21000 Dijon, France.
   [Christensen, Jeffrey E.; Collet, Xavier; Burcelin, Remy] Univ Toulouse III Paul Sabatier, UMR 1048, INSERM, F-31000 Toulouse, France.
   [Besnard, Philippe] AgroSup Dijon, Physiol Nutr, 26 Bd Dr Petitjean, F-21000 Dijon, France.
C3 Institut Agro; AgroSup Dijon; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Universite de Bourgogne; Institut National
   de la Sante et de la Recherche Medicale (Inserm); Universite de
   Toulouse; Universite Toulouse III - Paul Sabatier; Institut Agro;
   AgroSup Dijon; Universite de Bourgogne
RP Besnard, P (通讯作者)，Univ Bourgogne Franche Comte, UMR Lipides Nutr Canc 1231, INSERM, AgroSup Dijon, F-21000 Dijon, France.; Besnard, P (通讯作者)，AgroSup Dijon, Physiol Nutr, 26 Bd Dr Petitjean, F-21000 Dijon, France.
EM pbesnard@u-bourgogne.fr
RI BERNARD, Arnaud/C-9931-2019
OI BERNARD, Arnaud/0000-0002-2752-6702; Besnard,
   Philippe/0000-0002-3702-5709; simoneau, isabelle/0000-0002-9092-1908
FU  [ANR-12-BSV1-0027-01-SensoFAT2]
FX The authors are grateful to Michael Chevrot (PhD student at the time of
   this study), Geraldine Enderli and Marlene Gomes (engineers with a
   temporary position supported by the ANR-12-BSV1-0027-01-SensoFAT2 at the
   time of this study) for the 3-AFC tests.
CR Asano Y, 2012, AM J PHYSIOL-GASTR L, V303, pG1288, DOI 10.1152/ajpgi.00341.2012
   Besnard P, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-24619-1
   Blasco-Baque V, 2017, GUT, V66, P872, DOI 10.1136/gutjnl-2015-309897
   Brindisi MC, 2019, DIABETES METAB SYND, V13, P2489, DOI 10.1016/j.dsx.2019.06.021
   Chale-Rush A, 2007, CHEM SENSES, V32, P423, DOI 10.1093/chemse/bjm007
   Chevrot M, 2014, AM J CLIN NUTR, V99, P975, DOI 10.3945/ajcn.113.077198
   Chevrot M, 2013, J LIPID RES, V54, P2485, DOI 10.1194/jlr.M039446
   Engel-Yeger B, 2018, DISABIL REHABIL, V40, P3005, DOI 10.1080/09638288.2017.1365382
   Gondivkar SM, 2009, ORAL SURG ORAL MED O, V108, P876, DOI 10.1016/j.tripleo.2009.08.015
   Grasset E, 2017, CELL METAB, V26, P278, DOI 10.1016/j.cmet.2017.06.003
   Heath TP, 2006, J NEUROSCI, V26, P12664, DOI 10.1523/JNEUROSCI.3459-06.2006
   Helzner EP, 2016, CURR DIABETES REP, V16, DOI 10.1007/s11892-015-0696-0
   Jilani H, 2017, FOOD NUTR RES, V61, DOI 10.1080/16546628.2017.1348865
   Kaufman A, 2018, PLOS BIOL, V16, DOI 10.1371/journal.pbio.2001959
   Khera Shriya, 2018, Indian J Endocrinol Metab, V22, P204, DOI 10.4103/ijem.IJEM_555_17
   Lutchmansingh FK, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0198626
   Mardinoglu A, 2015, MOL SYST BIOL, V11, DOI 10.15252/msb.20156487
   Ohlrich Edward J, 2010, J Oral Microbiol, V2, DOI 10.3402/jom.v2i0.5818
   Olivarius ND, 2011, BMC PUBLIC HEALTH, V11, DOI 10.1186/1471-2458-11-80
   Paisse S, 2016, TRANSFUSION, V56, P1138, DOI 10.1111/trf.13477
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Schiffman Susan S, 2018, World J Otorhinolaryngol Head Neck Surg, V4, P84, DOI 10.1016/j.wjorl.2018.02.005
   Syed Q, 2016, AM J MED, V129, DOI 10.1016/j.amjmed.2016.02.003
   van Deursen RWM, 1999, J ORTHOP SPORT PHYS, V29, P718, DOI 10.2519/jospt.1999.29.12.718
   Wilbert SA, 2020, CELL REP, V30, P4003, DOI 10.1016/j.celrep.2020.02.097
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Yu JH, 2013, DIABETIC MED, V30, P1080, DOI 10.1111/dme.12209
   Zaghloul H, 2018, DIABETIC MED, V35, P41, DOI 10.1111/dme.13542
NR 28
TC 6
Z9 6
U1 3
U2 4
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 0940-5429
EI 1432-5233
J9 ACTA DIABETOL
JI Acta Diabetol.
PD DEC
PY 2020
VL 57
IS 12
BP 1445
EP 1451
DI 10.1007/s00592-020-01567-9
EA JUL 2020
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA OK4KQ
UT WOS:000549314000001
PM 32676702
OA Green Published, hybrid
DA 2023-06-08
ER

PT J
AU Tian, XX
   Wu, YY
   Duan, C
   Zhou, XH
   Li, Y
   Zheng, JB
   Lai, WH
   Zhang, SY
   Cao, LX
   Zhong, SL
AF Tian, XiaoXue
   Wu, Yuanyuan
   Duan, Cheng
   Zhou, Xiaohong
   Li, Yong
   Zheng, Jiabin
   Lai, Weihua
   Zhang, Shuyao
   Cao, Lixiang
   Zhong, Shilong
TI Tryptophan was metabolized into beneficial metabolites against coronary
   heart disease or prevented from producing harmful metabolites by the in
   vitro drug screening model based on Clostridium sporogenes
SO FRONTIERS IN MICROBIOLOGY
LA English
DT Article
DE in vitro drug screening model; tryptophan-derived metabolites;
   Clostridium sporogenes; indole-3-butyric acid; coronary heart disease
ID MICROBIOTA-DERIVED METABOLITES; KYNURENINE PATHWAY; GUT MICROBIOTA;
   5-HYDROXYINDOLE-3-ACETIC ACID; CARDIOVASCULAR-DISEASE; ACTIVATION;
   METFORMIN; ASSOCIATION; NEOPTERIN
AB In our previous study of 2,130 Chinese patients with coronary heart disease (CHD), we found that tryptophan (TRP) metabolites contributed to elevated risks of death. Many TRP-derived metabolites require the participation of intestinal bacteria to produce, and they play an important role in the pathogenesis of metabolic diseases such as CHD. So it is necessary to metabolize TRP into beneficial metabolites against CHD or prevent the production of harmful metabolites through external intervention. Indole-3-butyric acid (IBA) may be a key point of gut microbiota that causes TRP metabolism disorder and affects major adverse cardiovascular events in CHD. Therefore, this study aimed to develop a method based on in vitro culture bacteria to evaluate the effects of IBA on specific microbial metabolites quickly. We detected the concentrations of TRP and its metabolites in 11 bacterial strains isolated from feces using liquid chromatography-mass spectrometry, and selected Clostridium sporogenes as the model strain. Then, IBA was used in our model to explore its effect on TRP metabolism. Results demonstrated that the optimal culture conditions of C. sporogenes were as follows: initial pH, 6.8; culture temperature, 37 degrees C; and inoculum amount, 2%. Furthermore, we found that IBA increases the production of TRP and 5-HIAA by intervening TRP metabolism, and inhibits the production of KYNA. This new bacteria-specific in vitro model provides a flexible, reproducible, and cost-effective tool for identifying harmful agents that can decrease the levels of beneficial TRP metabolites. It will be helpful for researchers when developing innovative strategies for studying gut microbiota.
C1 [Tian, XiaoXue; Wu, Yuanyuan; Zhou, Xiaohong; Li, Yong; Zheng, Jiabin; Lai, Weihua; Zhong, Shilong] Guangdong Prov Peoples Hosp, Guangdong Acad Med Sci, Guangdong Cardiovasc Inst, Guangzhou, Guangdong, Peoples R China.
   [Tian, XiaoXue; Zhong, Shilong] Southern Med Univ, Sch Pharmaceut Sci, Guangzhou, Guangdong, Peoples R China.
   [Tian, XiaoXue; Lai, Weihua; Zhong, Shilong] Guangdong Prov Peoples Hosp, Guangdong Acad Med Sci, Dept Pharm, Guangzhou, Guangdong, Peoples R China.
   [Duan, Cheng] Greater Bay Area Inst Precis Med Guangzhou, Guangzhou, Guangdong, Peoples R China.
   [Li, Yong] Southern Med Univ, Sch Clin Med 2, Guangzhou, Guangdong, Peoples R China.
   [Zhang, Shuyao] Jinan Univ, Guangzhou Red Cross Hosp, Dept Pharm, Guangzhou, Guangdong, Peoples R China.
   [Cao, Lixiang] Sun Yat Sen Univ, Sch Life Sci, Guangzhou, Guangdong, Peoples R China.
C3 Guangdong Academy of Medical Sciences & Guangdong General Hospital;
   Southern Medical University - China; Southern Medical University -
   China; Guangdong Academy of Medical Sciences & Guangdong General
   Hospital; Southern Medical University - China; Southern Medical
   University - China; Jinan University; Sun Yat Sen University
RP Zhong, SL (通讯作者)，Guangdong Prov Peoples Hosp, Guangdong Acad Med Sci, Guangdong Cardiovasc Inst, Guangzhou, Guangdong, Peoples R China.; Zhong, SL (通讯作者)，Southern Med Univ, Sch Pharmaceut Sci, Guangzhou, Guangdong, Peoples R China.; Zhong, SL (通讯作者)，Guangdong Prov Peoples Hosp, Guangdong Acad Med Sci, Dept Pharm, Guangzhou, Guangdong, Peoples R China.; Zhang, SY (通讯作者)，Jinan Univ, Guangzhou Red Cross Hosp, Dept Pharm, Guangzhou, Guangdong, Peoples R China.; Cao, LX (通讯作者)，Sun Yat Sen Univ, Sch Life Sci, Guangzhou, Guangdong, Peoples R China.
EM shuyao0754@qq.com; lssclx@163.com; zhongsl@hotmail.com
RI tian, xiaoxue/GYA-4972-2022
OI Zhong, Shi-Long/0000-0002-2696-7696
CR Afarideh M, 2015, ENDOCR PRACT, V21, P711, DOI 10.4158/EP14442.OR
   Agus A, 2021, GUT, V70, P1174, DOI 10.1136/gutjnl-2020-323071
   Bakhta O, 2020, BASIC RES CARDIOL, V115, DOI 10.1007/s00395-019-0770-x
   Bartolomaeus H, 2019, CIRCULATION, V139, P1407, DOI 10.1161/CIRCULATIONAHA.118.036652
   Chen ML, 2016, MBIO, V7, DOI 10.1128/mBio.02210-15
   Chen Y, 2019, J CHROMATOGR B, V1128, DOI 10.1016/j.jchromb.2019.121745
   Damodaran S, 2019, FRONT PLANT SCI, V10, DOI 10.3389/fpls.2019.00851
   Dodd D, 2017, NATURE, V551, P648, DOI 10.1038/nature24661
   Egamberdieva D, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.02104
   Elmariah S, 2018, JAMA CARDIOL, V3, P242, DOI 10.1001/jamacardio.2017.4873
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Fukui M, 2012, DIABETES CARE, V35, P163, DOI 10.2337/dc11-1619
   Gaspar R, 2022, FRONT IMMUNOL, V12, DOI 10.3389/fimmu.2021.768560
   Gheorghe CE, 2019, CURR OPIN PHARMACOL, V48, P137, DOI 10.1016/j.coph.2019.08.004
   Guo CJ, 2019, SCIENCE, V366, P1331, DOI 10.1126/science.aav1282
   Haiser HJ, 2013, SCIENCE, V341, P295, DOI 10.1126/science.1235872
   He XY, 2017, J PROTEOME RES, V16, P1900, DOI 10.1021/acs.jproteome.6b00984
   IKEDA K, 1984, J PHARM PHARMACOL, V36, P663, DOI 10.1111/j.2042-7158.1984.tb04839.x
   Jie ZY, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-00900-1
   Kazemian N, 2020, MICROBIOME, V8, DOI 10.1186/s40168-020-00821-0
   Kim M, 2022, CARDIOVASC RES, V118, P399, DOI 10.1093/cvr/cvab030
   Lavelle A, 2020, NAT REV GASTRO HEPAT, V17, P223, DOI 10.1038/s41575-019-0258-z
   Li LY, 2018, J PROTEOME RES, V17, P154, DOI 10.1021/acs.jproteome.7b00461
   Li Qing, 2022, Am J Clin Nutr, V116, P1070, DOI 10.1093/ajcn/nqac170
   Liu G, 2021, AM J CLIN NUTR, V114, P238, DOI 10.1093/ajcn/nqab053
   Liu G, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/1602074
   Liu HH, 2019, MICROBIOME, V7, DOI 10.1186/s40168-019-0683-9
   Liu HG, 2020, CURR ATHEROSCLER REP, V22, DOI 10.1007/s11883-020-00892-2
   Liu JR, 2021, CELL MOL LIFE SCI, V78, P909, DOI 10.1007/s00018-020-03645-1
   Ma L, 2014, P NATL ACAD SCI USA, V111, P9768, DOI 10.1073/pnas.1404753111
   McDonald JAK, 2013, J MICROBIOL METH, V95, P167, DOI 10.1016/j.mimet.2013.08.008
   Modoux M, 2021, TRENDS PHARMACOL SCI, V42, P60, DOI 10.1016/j.tips.2020.11.006
   Murr C, 2015, EUR J CLIN INVEST, V45, P247, DOI 10.1111/eci.12402
   Natividad JM, 2018, CELL METAB, V28, P737, DOI 10.1016/j.cmet.2018.07.001
   Pedersen ER, 2011, ARTERIOSCL THROM VAS, V31, P698, DOI 10.1161/ATVBAHA.110.219329
   Platten M, 2019, NAT REV DRUG DISCOV, V18, P379, DOI 10.1038/s41573-019-0016-5
   Poehlein A, 2015, STAND GENOMIC SCI, V10, DOI 10.1186/s40793-015-0016-y
   Pollak M, 2017, DIABETOLOGIA, V60, P1662, DOI 10.1007/s00125-017-4352-x
   Purton T, 2021, NEUROSCI BIOBEHAV R, V123, P1, DOI 10.1016/j.neubiorev.2020.12.026
   Ray KK, 2007, CIRCULATION, V115, P3071, DOI 10.1161/CIRCULATIONAHA.106.666511
   Roager HM, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-018-05470-4
   Rosser EC, 2020, CELL METAB, V31, P837, DOI 10.1016/j.cmet.2020.03.003
   Sakurai T, 2019, MICROORGANISMS, V7, DOI 10.3390/microorganisms7090340
   Santisukwongchote K, 2020, METABOLITES, V10, DOI 10.3390/metabo10010006
   Schwarcz R, 2017, NEUROPHARMACOLOGY, V112, P237, DOI 10.1016/j.neuropharm.2016.08.003
   Skye SM, 2018, CIRC RES, V123, P1164, DOI 10.1161/CIRCRESAHA.118.313142
   Song P, 2017, CELL MOL LIFE SCI, V74, P2899, DOI 10.1007/s00018-017-2504-2
   Sulo G, 2013, INT J CARDIOL, V168, P1435, DOI 10.1016/j.ijcard.2012.12.090
   Taleb S, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.02113
   Verheyen N, 2017, CLIN CHEM LAB MED, V55, P1034, DOI 10.1515/cclm-2016-1159
   Wang ZX, 2021, CLIN TRANSL MED, V11, DOI 10.1002/ctm2.290
   Wicha-Komsta K, 2021, J CHROMATOGR SCI, V59, P40, DOI 10.1093/chromsci/bmaa074
   Wikoff WR, 2009, P NATL ACAD SCI USA, V106, P3698, DOI 10.1073/pnas.0812874106
   Wirleitner B, 2003, EUR J CLIN INVEST, V33, P550, DOI 10.1046/j.1365-2362.2003.01186.x
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Yano JM, 2015, CELL, V161, P264, DOI 10.1016/j.cell.2015.02.047
   Yoon HS, 2020, NUTR METAB CARDIOVAS, V30, P467, DOI 10.1016/j.numecd.2019.10.011
   Yu E, 2017, J NUTR, V147, P314, DOI 10.3945/jn.116.241711
   Zhang J, 2021, MED RES REV, V41, P1061, DOI 10.1002/med.21752
   Zhang LS, 2016, GENOME MED, V8, DOI 10.1186/s13073-016-0296-x
   Zhu Q., 2018, USAGE ENDOGENOUS MET
   Zuo H, 2016, AM J EPIDEMIOL, V183, P249, DOI 10.1093/aje/kwv242
NR 62
TC 0
Z9 0
U1 11
U2 11
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1664-302X
J9 FRONT MICROBIOL
JI Front. Microbiol.
PD NOV 16
PY 2022
VL 13
AR 1013973
DI 10.3389/fmicb.2022.1013973
PG 14
WC Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology
GA 6Q4FX
UT WOS:000891570100001
PM 36466649
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Zhao, JD
   Li, Y
   Sun, M
   Xin, L
   Wang, TM
   Wei, LB
   Yu, CJ
   Liu, MM
   Ni, YQ
   Lu, RM
   Bao, TT
   Zhang, L
   Wu, YY
   Fang, ZH
AF Zhao, Jindong
   Li, Yan
   Sun, Min
   Xin, Ling
   Wang, Tianming
   Wei, Liangbing
   Yu, Chanjuan
   Liu, Mengmeng
   Ni, Yingqun
   Lu, Ruimin
   Bao, Taotao
   Zhang, Lu
   Wu, Yuanyuan
   Fang, Zhaohui
TI The Chinese Herbal Formula Shenzhu Tiaopi Granule Results in Metabolic
   Improvement in Type 2 Diabetic Rats by Modulating the Gut Microbiota
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID METFORMIN
AB Objective. The aim of this study is to investigate the implication of the Chinese herbal formula (CHF) Shenzhu tiaopi Granule (STG) in type 2 diabetes mellitus (T2DM) and discuss the mechanisms by which STG regulates the gut microbiota. Method. Goto-Kakizaki (GK) rats and age-matched Wistar (W) rats were acclimatized for 1 week. The GK rats were randomly divided into 3 groups and orally gavaged with saline (model group, M), acarbose (acarbose group, A), and STG (granule of CHF group, G; the component of this formula includes Codonopsis pilosula, Rhizoma Atractylodis, Pinellia, Poria cocos, Pericarpium Citri Reticulatae, Coptis chinensis Franch, and Pueraria). The W rats were orally gavaged with saline (control group, C). The observation time was 8 weeks. The weight, fasting blood glucose (FBG) level, and blood lipid levels were tested. The 16S rRNA genes in the V3-V4 region were sequenced, and the structure of the gut microbiota was analysed. Results. Compared to C, M displayed significant differences in blood glucose, gut microbiota, etc. (P<0.05; P<0.01). Compared to M, A and G showed a similar reduction in the FBG gain and a shift in the structure of the gut microbiota (P<0.05; P<0.01). Compared with A, G exhibited a significant decrease in weight, FBG level, and total cholesterol (P<0.05). The gut microbiota, Bacteroidetes, the Firmicutes/Bacteroidetes ratio, Allobaculum, and Desulfovibrionaceae were significantly decreased in response to the STG treatment, while Lactobacillus was significantly enriched (P<0.05; P<0.01). The community composition also differed at the phylum and genus levels based on the linear discriminant analysis effect size and heat map. Conclusion. Our findings suggest that the composition of the gut microbiota was significantly changed in the diabetic GK rats compared with that in the normal W rats. STG treatment can improve glucose and lipid levels and modulate the gut microbiota in T2DM rats.
C1 [Zhao, Jindong; Yu, Chanjuan; Liu, Mengmeng; Ni, Yingqun; Lu, Ruimin; Bao, Taotao; Zhang, Lu; Wu, Yuanyuan; Fang, Zhaohui] Anhui Univ Chinese Med, Affiliated Hosp 1, Dept Endocrinol, Hefei 230031, Anhui, Peoples R China.
   [Zhao, Jindong; Fang, Zhaohui] Anhui Acad Chinese Med, Diabet Inst, Hefei 230012, Anhui, Peoples R China.
   [Li, Yan] Anhui Univ Chinese Med, Affiliated Hosp 1, Dept Infect Dis, Hefei 230031, Anhui, Peoples R China.
   [Sun, Min] Anhui Univ, Sch Life Sci, Hefei 230039, Anhui, Peoples R China.
   [Xin, Ling] Anhui Univ Chinese Med, Affiliated Hosp 1, Dept Comp Ctr, Hefei 230031, Anhui, Peoples R China.
   [Wang, Tianming] Anhui Univ Chinese Med, Dept Technol, Hefei 230038, Anhui, Peoples R China.
   [Wei, Liangbing] Anhui Univ Chinese Med, Affiliated Hosp 1, Dept Pharm, Hefei 230031, Anhui, Peoples R China.
C3 Anhui University of Chinese Medicine; Anhui University of Chinese
   Medicine; Anhui University of Chinese Medicine; Anhui University; Anhui
   University of Chinese Medicine; Anhui University of Chinese Medicine;
   Anhui University of Chinese Medicine
RP Fang, ZH (通讯作者)，Anhui Univ Chinese Med, Affiliated Hosp 1, Dept Endocrinol, Hefei 230031, Anhui, Peoples R China.; Fang, ZH (通讯作者)，Anhui Acad Chinese Med, Diabet Inst, Hefei 230012, Anhui, Peoples R China.
EM fangzhaohui1111@163.com
RI SUN, MIN/GQZ-7245-2022
FU National Natural Science Foundation of China [81573944, 81603574,
   81774286]; Province Science Foundation of Anhui [1708085QH213]; TCM
   Modernization Research of National Key Research and Development Program
   [2018YFC1704200]
FX This study was supported by the National Natural Science Foundation of
   China (81573944, 81603574, and 81774286), the Province Science
   Foundation of Anhui (1708085QH213), and TCM Modernization Research of
   National Key Research and Development Program (2018YFC1704200).
CR Altschul SF, 1997, NUCLEIC ACIDS RES, V25, P3389, DOI 10.1093/nar/25.17.3389
   Asnicar F, 2015, PEERJ, V3, DOI 10.7717/peerj.1029
   BEERENS H, 1977, AM J CLIN NUTR, V30, P1770, DOI 10.1093/ajcn/30.11.1770
   BODE L, 2002, AMERICAN JOURNAL OF, V97, P295, DOI DOI 10.3945/AJCN.112.049379
   CANI P, 2002, CURRENT PHARMACEUTIC, V15, P1546
   *CHIN PHARM COMM, 2005, PHARM PEOPL REP CHIN, V1
   CLARKE KR, 1993, AUST J ECOL, V18, P117, DOI 10.1111/j.1442-9993.1993.tb00438.x
   Cotter PD, 2003, MICROBIOL MOL BIOL R, V67, P429, DOI 10.1128/MMBR.67.3.429-453.2003
   DeSantis TZ, 2006, APPL ENVIRON MICROB, V72, P5069, DOI 10.1128/AEM.03006-05
   Dustin M., 2018, CARDIOVASC DIABETOL, V17, P62
   Edgar RC, 2013, NAT METHODS, V10, P996, DOI [10.1038/nmeth.2604, 10.1038/NMETH.2604]
   Fang ZH, 2014, COMPLEMENT THER MED, V22, P842, DOI 10.1016/j.ctim.2014.08.004
   Fei N, 2013, ISME J, V7, P880, DOI 10.1038/ismej.2012.153
   Ganesan K, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19123720
   Gao H, 2018, CARBOHYD POLYM, V201, P624, DOI 10.1016/j.carbpol.2018.08.075
   Jing YP, 2018, BIOMED RES INT, V2018, DOI 10.1155/2018/1781036
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   KITAHARA A, 1978, TOHOKU J EXP MED, V126, P7, DOI 10.1620/tjem.126.7
   Kiyotaka W., 2014, HIROSAKI MED J, V65, P12
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Leikin J. B., 2008, POISONING TOXICOLOGY, P892
   Lian FM, 2014, J CLIN ENDOCR METAB, V99, P648, DOI 10.1210/jc.2013-3276
   Loubinoux J, 2000, J CLIN MICROBIOL, V38, P931, DOI 10.1128/JCM.38.2.931-934.2000
   Magoc T, 2011, BIOINFORMATICS, V27, P2957, DOI 10.1093/bioinformatics/btr507
   MARUHAMA Y, 1980, TOHOKU J EXP MED, V132, P453, DOI 10.1620/tjem.132.453
   McArdle BH, 2001, ECOLOGY, V82, P290, DOI 10.1890/0012-9658(2001)082[0290:fmmtcd]2.0.co;2
   Moreno-Indias I, 2014, FRONT MICROBIOL, V5, DOI 10.3389/fmicb.2014.00190
   Musso G, 2010, DIABETES CARE, V33, P2277, DOI 10.2337/dc10-0556
   Niibo M, 2019, J DAIRY SCI, V102, P997, DOI 10.3168/jds.2018-15203
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Ramette A, 2007, FEMS MICROBIOL ECOL, V62, P142, DOI 10.1111/j.1574-6941.2007.00375.x
   RECTOR R, 2002, J HEPATOL, V52, P727
   Sane F, 2018, J NUTR BIOCHEM, V62, P108, DOI 10.1016/j.jnutbio.2018.08.017
   SHANNON C, 1926, M D COMPUT, V14, P306
   Shi YL, 2016, CHINESE MED J-PEKING, V129, P2281, DOI 10.4103/0366-6999.190676
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Simons AL, 2005, J AGR FOOD CHEM, V53, P4258, DOI 10.1021/jf0500177
   Su BL, 2015, J DIABETES, V7, P729, DOI 10.1111/1753-0407.12232
   Tong XL, 2013, DIABETES OBES METAB, V15, P448, DOI 10.1111/dom.12051
   Tremaroli V, 2012, NATURE, V489, P242, DOI 10.1038/nature11552
   Wang JH, 2015, SCI REP-UK, V5, DOI 10.1038/srep08391
   Wang LL, 2017, J CHROMATOGR B, V1057, P70, DOI 10.1016/j.jchromb.2017.05.004
   Warton DI, 2012, METHODS ECOL EVOL, V3, P89, DOI 10.1111/j.2041-210X.2011.00127.x
   Wei XY, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-22094-2
   Xu K, 2017, SCI REP-UK, V7, DOI 10.1038/srep41718
   Xue B, 2016, FOOD FUNCT, V7, P1501, DOI 10.1039/c5fo01438g
   Yadav R, 2018, MICROB PATHOGENESIS, V125, P454, DOI 10.1016/j.micpath.2018.10.015
   YAN H, 2002, PHYTOMEDICINE, V26, P45, DOI DOI 10.1016/j.phymed.2017.01.007
   Yang L, 2016, MOL ENDOCRINOL, V30, P361, DOI 10.1210/me.2015-1213
   Yang WY, 2014, LANCET DIABETES ENDO, V2, P46, DOI 10.1016/S2213-8587(13)70021-4
   Zhang CH, 2010, ISME J, V4, P312, DOI 10.1038/ismej.2009.144
   Zhang Q, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0184735
   Zhang XQ, 2015, SCI REP-UK, V5, DOI 10.1038/srep10737
   Zhao L, 2017, FOOD FUNCT, V8, P4644, DOI [10.1039/c7fo01383c, 10.1039/C7FO01383C]
   Zhao L, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00233
NR 56
TC 16
Z9 17
U1 2
U2 24
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2019
VL 2019
AR 6976394
DI 10.1155/2019/6976394
PG 14
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA ID8DT
UT WOS:000471913800001
PM 31275416
OA gold, Green Published, Green Submitted
DA 2023-06-08
ER

PT J
AU Mishra, SP
   Jain, S
   Taraphder, S
   Yadav, H
AF Mishra, Sidharth P.
   Jain, Shalini
   Taraphder, Subhash
   Yadav, Hariom
TI New Horizons in Microbiota and Metabolic Health Research
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
DE microbiota; gut; metabolic; diabetes; obesity; inflammation; brain
ID GUT MICROBIOTA; HYPOTHALAMUS; INFLAMMATION; EXPRESSION; METFORMIN; AXIS
AB Decade-old studies have demonstrated that microbes living in our gut (microbiota) contribute to both maintaining normal metabolic function and to the pathology of metabolic diseases, such as obesity and diabetes. Emerging evidence suggests that gut microbiota influences the personalized effects of diets and drugs and impact the gut-brain axis and leaky gut inflammation to control metabolic function/diseases. Gut microbiota can be an ideal source of prognostic markers and therapies for metabolic diseases. Here we discuss the emerging concepts in the area of microbiota and metabolic interactions in personalized nutrition, drug response, and disease prognosis.
C1 [Mishra, Sidharth P.; Yadav, Hariom] Wake Forest Sch Med, Dept Internal Med Mol Med, Winston Salem, NC 27101 USA.
   [Mishra, Sidharth P.; Taraphder, Subhash] West Bengal Univ Anim & Fishery Sci, Dept Anim Genet & Breeding, Kolkata 700037, W Bengal, India.
   [Jain, Shalini] Wake Forest Sch Med, Metab Phenotyping Shared Resource, Winston Salem, NC 27101 USA.
   [Jain, Shalini] Wake Forest Sch Med, Dept Internal Med Endocrinol, Winston Salem, NC 27101 USA.
C3 Wake Forest University; West Bengal University of Animal & Fishery
   Sciences; Wake Forest University; Wake Forest University
RP Yadav, H (通讯作者)，Wake Forest Sch Med, Dept Internal Med Mol Med, Gut Microbiota & Metab Dis Grp, Winston Salem, NC 27101 USA.
EM hyadav@wakehealth.edu
RI Yadav, Hariom/I-2455-2018
OI Yadav, Hariom/0000-0003-4504-1597; Mishra, Sidharth
   Prasad/0000-0001-7586-846X
FU National Institutes of Health [R01AG018915]; Pepper Older Americans for
   Independence Center [P30AG21332]; Department of Defense
   [W81XWH-19-1-0236]; Center for Diabetes, Obesity and Metabolism, Wake
   Forest Baptist Medical Center; National Center for Advancing
   Translational Sciences (NCATS); National Institutes of Health-Funded
   Wake Forest Clinical and Translational Science Institute (WF CTSI)
   [UL1TR001420]
FX We are thankful for the support provided by the National Institutes of
   Health grants R01AG018915 and the Pepper Older Americans for
   Independence Center (P30AG21332), and the Department of Defense funding
   W81XWH-19-1-0236 (to H.Y.), as well funds and services provided from the
   Center for Diabetes, Obesity and Metabolism, Wake Forest Baptist Medical
   Center, and the National Center for Advancing Translational Sciences
   (NCATS), and the National Institutes of Health-Funded Wake Forest
   Clinical and Translational Science Institute (WF CTSI) through Grant
   Award Number UL1TR001420.
CR Abdul-Wahed A, 2014, MOL METAB, V3, P531, DOI 10.1016/j.molmet.2014.05.005
   Abell GCJ, 2008, FEMS MICROBIOL ECOL, V66, P505, DOI 10.1111/j.1574-6941.2008.00527.x
   Ahmadi S, 2020, JCI INSIGHT, V5, DOI 10.1172/jci.insight.132055
   Ahmadi S, 2020, J GERONTOL A-BIOL, V75, pE9, DOI 10.1093/gerona/glaa056
   Ahmadi S, 2019, J NUTR BIOCHEM, V67, P1, DOI 10.1016/j.jnutbio.2019.01.011
   Bailey MT, 2011, BRAIN BEHAV IMMUN, V25, P397, DOI 10.1016/j.bbi.2010.10.023
   Bravo JA, 2011, P NATL ACAD SCI USA, V108, P16050, DOI 10.1073/pnas.1102999108
   Burton Jeffrey H, 2015, J Diabetes Sci Technol, V9, P808, DOI 10.1177/1932296815577425
   Canfora EE, 2019, NAT REV ENDOCRINOL, V15, P261, DOI 10.1038/s41574-019-0156-z
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Chakaroun RM, 2020, NUTRIENTS, V12, DOI 10.3390/nu12041082
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   De Vadder F, 2016, CELL METAB, V24, P151, DOI 10.1016/j.cmet.2016.06.013
   De Vadder F, 2014, CELL, V156, P84, DOI 10.1016/j.cell.2013.12.016
   Foretz M, 2019, NAT REV ENDOCRINOL, V15, P569, DOI 10.1038/s41574-019-0242-2
   Grasset E, 2017, CELL METAB, V25, P1075, DOI 10.1016/j.cmet.2017.04.013
   Haiser HJ, 2013, SCIENCE, V341, P295, DOI 10.1126/science.1235872
   Hill C, 2014, NAT REV GASTRO HEPAT, V11, P506, DOI 10.1038/nrgastro.2014.66
   Jia LL, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-07335-0
   Kim MS, 2013, ENV MICROBIOL REP, V5, P765, DOI 10.1111/1758-2229.12079
   Kimura I, 2020, SCIENCE, V367, P1002, DOI 10.1126/science.aaw8429
   Lam YY, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0034233
   Lundgren P, 2020, AM J PHYSIOL-GASTR L, V318, pG717, DOI 10.1152/ajpgi.00304.2019
   Macpherson AJ, 2016, CELL HOST MICROBE, V20, P561, DOI 10.1016/j.chom.2016.10.016
   Marchesi JR, 2016, GUT, V65, P330, DOI 10.1136/gutjnl-2015-309990
   Marino RAM, 2020, P NATL ACAD SCI USA, V117, P8611, DOI 10.1073/pnas.1909340117
   Martinez I, 2013, ISME J, V7, P269, DOI 10.1038/ismej.2012.104
   Mishra S, 2019, MICROORGANISMS, V7, DOI 10.3390/microorganisms7030067
   Mishra SP, 2020, BIOMEDICINES, V8, DOI 10.3390/biomedicines8060154
   Morrison DJ, 2016, GUT MICROBES, V7, P189, DOI 10.1080/19490976.2015.1134082
   Nagpal R, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21103434
   Palou M, 2009, CELL PHYSIOL BIOCHEM, V23, P115, DOI 10.1159/000204100
   Reitmeier S, 2020, CELL HOST MICROBE, V28, P258, DOI 10.1016/j.chom.2020.06.004
   Ridaura VK, 2013, SCIENCE, V341, P1079, DOI 10.1126/science.1241214
   Rodriguez J, 2018, CURR OPIN CLIN NUTR, V21, P294, DOI 10.1097/MCO.0000000000000468
   Sanders ME, 2019, NAT REV GASTRO HEPAT, V16, P605, DOI 10.1038/s41575-019-0173-3
   Scott KP, 2020, J APPL MICROBIOL, V128, P934, DOI 10.1111/jam.14424
   Strandwitz P, 2018, BRAIN RES, V1693, P128, DOI 10.1016/j.brainres.2018.03.015
   Vallianou NG, 2019, HORM-INT J ENDOCRINO, V18, P141, DOI 10.1007/s42000-019-00093-w
   Walker AW, 2011, ISME J, V5, P220, DOI 10.1038/ISMEJ.2010.118
   Wang SH, 2020, GEROSCIENCE, V42, P333, DOI 10.1007/s11357-019-00137-4
   West NP, 2013, EXERC IMMUNOL REV, V19, P102
   Wu H, 2020, CELL METAB, V32, P379, DOI 10.1016/j.cmet.2020.06.011
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Xu YH, 2018, J ENDOCRINOL, V238, P231, DOI 10.1530/JOE-18-0137
   Zhang XY, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0071108
NR 46
TC 2
Z9 2
U1 5
U2 15
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD JAN 23
PY 2021
VL 106
IS 2
BP E1052
EP E1059
DI 10.1210/clinem/dgaa769
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA ZE8GF
UT WOS:000759115900092
PM 33128374
OA Bronze, Green Published
DA 2023-06-08
ER

PT J
AU Hodge, RJ
   Paulik, MA
   Walker, A
   Boucheron, JA
   McMullen, SL
   Gillmor, DS
   Nunez, DJ
AF Hodge, Rebecca J.
   Paulik, Mark A.
   Walker, Ann
   Boucheron, Joyce A.
   McMullen, Susan L.
   Gillmor, Dawn S.
   Nunez, Derek J.
TI Weight and Glucose Reduction Observed with a Combination of Nutritional
   Agents in Rodent Models Does Not Translate to Humans in a Randomized
   Clinical Trial with Healthy Volunteers and Subjects with Type 2 Diabetes
SO PLOS ONE
LA English
DT Article
ID GUT MICROBIOTA; INSULIN-RESISTANCE; OLIGOFRUCTOSE; OBESITY; MICE; DIET;
   FAT; INFLAMMATION; MANAGEMENT; INGESTION
AB Background
   Nutritional agents have modest efficacy in reducing weight and blood glucose in animal models and humans, but combinations are less well characterized. GSK2890457 (GSK457) is a combination of 4 nutritional agents, discovered by the systematic assessment of 16 potential components using the diet-induced obese mouse model, which was subsequently evaluated in a human study.
   Nonclinical Results
   In the diet-induced obese mouse model, GSK457 (15% w/w in chow) given with a long-acting glucagon-like peptide -1 receptor agonist, exendin-4 AlbudAb, produced weight loss of 30.8% after 28 days of treatment. In db/db mice, a model of diabetes, GSK457 (10% w/w) combined with the exendin-4 AlbudAb reduced glucose by 217 mg/dL and HbA1c by 1.2% after 14 days.
   Clinical Results
   GSK457 was evaluated in a 6 week randomized, placebo-controlled study that enrolled healthy subjects and subjects with type 2 diabetes to investigate changes in weight and glucose. In healthy subjects, GSK457 well tolerated when titrated up to 40 g/day, and it reduced systemic exposure of metformin by similar to 30%. In subjects with diabetes taking liraglutide 1.8 mg/day, GSK457 did not reduce weight, but it slightly decreased mean glucose by 0.356 mmol/L (95% CI: -1.409, 0.698) and HbAlc by 0.065% (95% CI: -0.495, 0.365), compared to placebo. In subjects with diabetes taking metformin, weight increased in the GSK457-treated group [adjusted mean % increase from baseline: 1.26% (95% CI: -0.24, 2.75)], and mean glucose and HbA1c were decreased slightly compared to placebo [adjusted mean glucose change from baseline: -1.22 mmol/L (95% CI: -2.45, 0.01); adjusted mean HbA1c change from baseline: -0.219% (95% CI: -0.910, 0.472)].
   Conclusions
   Our data demonstrate remarkable effects of GSK457 in rodent models of obesity and diabetes, but a marked lack of translation to humans. Caution should be exercised with nutritional agents when predicting human efficacy from rodent models of obesity and diabetes.
C1 [Hodge, Rebecca J.; Nunez, Derek J.] GlaxoSmithKline, Metab Pathways Cardiovasc Unit, Discovery Med, Res Triangle Pk, NC USA.
   [Paulik, Mark A.; Boucheron, Joyce A.] GlaxoSmithKline, Metab Pathways Cardiovasc Unit, Biol, Res Triangle Pk, NC USA.
   [Walker, Ann] GlaxoSmithKline, Quantitat Sci Clin Stat, R&D Projects Clin Platforms & Sci, Res Triangle Pk, NC USA.
   [McMullen, Susan L.; Gillmor, Dawn S.] GlaxoSmithKline, Clin Pharmacol Sci & Study Operat, Res Triangle Pk, NC USA.
   [Paulik, Mark A.] Intarcia Therapeut, Res Triangle Pk, NC USA.
   [McMullen, Susan L.] PAREXEL Int, Durham, NC USA.
   [Gillmor, Dawn S.] PPD Inc, Morrisville, NC USA.
C3 GlaxoSmithKline; GlaxoSmithKline; GlaxoSmithKline; GlaxoSmithKline;
   Parexel International
RP Hodge, RJ (通讯作者)，GlaxoSmithKline, Metab Pathways Cardiovasc Unit, Discovery Med, Res Triangle Pk, NC USA.
EM rhodge.dvm@gmail.com
FU GlaxoSmithKline plc
FX The funder (GlaxoSmithKline plc) provided support in the form of
   salaries for authors RJH, MAP, AW, JAB, SLM, DSG, and DJN and provided
   general feedback on study design. The authors were solely responsible
   for data collection and analysis and preparation of the manuscript. It
   is current GlaxoSmithKline policy that all clinical studies be
   published. The specific roles of these authors are articulated in the
   'author contributions' section.
CR [Anonymous], 1998, NIH PUBLICATION, P12
   Astrup A, 2009, LANCET, V374, P1606, DOI 10.1016/S0140-6736(09)61375-1
   Burant CF, 2013, DIABETES CARE, V36, pS175, DOI 10.2337/dcS13-2037
   Cani PD, 2009, GUT, V58, P1091, DOI 10.1136/gut.2008.165886
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Cani PD, 2013, CURR OPIN PHARMACOL, V13, P935, DOI 10.1016/j.coph.2013.09.008
   Carr RD, 2008, AM J PHYSIOL-ENDOC M, V295, pE779, DOI 10.1152/ajpendo.90233.2008
   Chakravarthy MV, 2009, CELL, V138, P476, DOI 10.1016/j.cell.2009.05.036
   Delzenne NM, 2005, BRIT J NUTR, V93, pS157, DOI 10.1079/BJN20041342
   den Besten G, 2013, J LIPID RES, V54, P2325, DOI 10.1194/jlr.R036012
   DILORENZO C, 1988, GASTROENTEROLOGY, V95, P1211, DOI 10.1016/0016-5085(88)90352-6
   Everard A, 2013, BEST PRACT RES CL GA, V27, P73, DOI 10.1016/j.bpg.2013.03.007
   GIBSON GR, 1995, GASTROENTEROLOGY, V108, P975, DOI 10.1016/0016-5085(95)90192-2
   Godlewski G, 2009, PROSTAG OTH LIPID M, V89, P105, DOI 10.1016/j.prostaglandins.2009.07.001
   Guo HH, 2012, J NUTR BIOCHEM, V23, P349, DOI 10.1016/j.jnutbio.2010.12.013
   HOWARD MD, 1995, J NUTR, V125, P2604
   International Conference of Harmonisation, 1996, ICH HARM TRIP GUID G
   Inzucchi SE, 2015, DIABETES CARE, V38, P140, DOI 10.2337/dc14-2441
   Janssen S, 2013, TRENDS ENDOCRIN MET, V24, P92, DOI 10.1016/j.tem.2012.11.006
   Karra E, 2010, MOL CELL ENDOCRINOL, V316, P120, DOI 10.1016/j.mce.2009.06.010
   Kleessen B, 2001, BRIT J NUTR, V86, P291, DOI 10.1079/BJN2001403
   Ley RE, 2005, P NATL ACAD SCI USA, V102, P11070, DOI 10.1073/pnas.0504978102
   Moran TH, 2009, INT J OBESITY, V33, pS7, DOI 10.1038/ijo.2009.9
   Munir KM, 2013, AM J PHYSIOL-ENDOC M, V305, pE679, DOI 10.1152/ajpendo.00377.2013
   Napolitano A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100778
   Ng Marie, 2014, Lancet, V384, P766, DOI 10.1016/S0140-6736(14)60460-8
   Parnell JA, 2009, AM J CLIN NUTR, V89, P1751, DOI 10.3945/ajcn.2009.27465
   Puddu Alessandra, 2014, Mediators Inflamm, V2014, P162021, DOI 10.1155/2014/162021
   Rie S, 2007, BIOCHEM PHARMACOL, V74, P1619, DOI 10.1016/j.bcp.2007.08.008
   SCHWARTZ SE, 1988, AM J CLIN NUTR, V48, P1413, DOI 10.1093/ajcn/48.6.1413
   SVEDLUND J, 1988, DIGEST DIS SCI, V33, P129, DOI 10.1007/BF01535722
   Teres S, 2008, P NATL ACAD SCI USA, V105, P13811, DOI 10.1073/pnas.0807500105
   Tharakan G, 2011, TRENDS PHARMACOL SCI, V32, P8, DOI 10.1016/j.tips.2010.10.003
   Tsuda T, 2008, J AGR FOOD CHEM, V56, P642, DOI 10.1021/jf073113b
   World Med Assoc, 2013, JAMA-J AM MED ASSOC, V310, P2191, DOI 10.1001/jama.2013.281053
   Zhang D, 2014, DRUG DES DEV THER, V8, P1013, DOI 10.2147/DDDT.S53892
NR 36
TC 6
Z9 6
U1 0
U2 15
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 19
PY 2016
VL 11
IS 4
AR e0153151
DI 10.1371/journal.pone.0153151
PG 24
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA DJ9NW
UT WOS:000374541200014
PM 27093610
OA Green Published, Green Submitted, gold
DA 2023-06-08
ER

PT J
AU Gamede, M
   Mabuza, L
   Ngubane, P
   Khathi, A
AF Gamede, Mlindeli
   Mabuza, Lindokuhle
   Ngubane, Phikelelani
   Khathi, Andile
TI Plant-derived oleanolic acid ameliorates markers of subclinical
   inflammation and innate immunity activation in diet-induced pre-diabetic
   rats
SO THERAPEUTIC ADVANCES IN ENDOCRINOLOGY AND METABOLISM
LA English
DT Article
DE C-reactive protein; fibrinogen; immune cell activation; low-grade
   inflammation; oleanolic acid; pre-diabetes
ID FATTY LIVER-DISEASE; CAROTID ATHEROSCLEROSIS; PLATELET ACTIVATION;
   ADIPOSE-TISSUE; GUT MICROBIOTA; UP-REGULATION; METFORMIN; METABOLISM;
   FIBRINOGEN; NETWORK
AB Aims: Sub-clinical inflammation during pre-diabetes is one of the predisposing factors that facilitates the progression of pre-diabetes to type 2 diabetes. The administration of oleanolic acid (OA) with or without dietary intervention ameliorates the metabolic and cardiovascular complications in diet-induced pre-diabetes animal models of pre-diabetes. This study aimed to investigate whether OA can also suppress immune activation and ameliorate pro-inflammatory markers. Methods: Pre-diabetes was induced by feeding Sprague Dawley rats a high-fat high carbohydrate diet for 20 weeks. The pre-diabetic rats were then treated with OA (80 mg/kg) or metformin (500 mg/kg) in the presence or absence of dietary interventions for a period of 12 weeks. At the end of the treatment period, the animals were euthanised and whole blood was used for platelet and immune cell count while plasma was used for fibrinogen, cluster differentiation 40 ligand and pro-inflammatory cytokine evaluation. Results: The results of this study revealed that OA, with or without dietary intervention, improved lipid metabolism by restoring high-density lipoprotein (HDL) and low-density lipoproteins (LDLs) as well as reducing platelets and immune cell counts. Furthermore, OA also decreased plasma proinflammatory cytokines, including tumour necrosis factor-alpha and -1 beta. Markers of immune activation such as C-reactive protein, fibrinogen, and CD40L were also decreased upon administration of OA with or without dietary intervention. Conclusion: The findings of this study suggest that OA may provide an alternative to prevent the progression of pre-diabetes to overt diabetes. This was evident by the reduction of differential white blood cell count and proinflammatory cytokines that exercebate insulin resistance. However, more studies are needed to elucidate the molecular mechanisms and to improve efficacy.
C1 [Gamede, Mlindeli] Univ KwaZulu Natal, Coll Hlth Sci, Sch Lab Med & Med Sci, Dept Human Physiol, Room E3-408,54 Univ Rd, ZA-4000 Durban, South Africa.
   [Mabuza, Lindokuhle; Ngubane, Phikelelani; Khathi, Andile] Univ KwaZulu Natal, Coll Hlth Sci, Sch Lab Med & Med Sci, Durban, South Africa.
C3 University of Kwazulu Natal; University of Kwazulu Natal
RP Gamede, M (通讯作者)，Univ KwaZulu Natal, Coll Hlth Sci, Sch Lab Med & Med Sci, Dept Human Physiol, Room E3-408,54 Univ Rd, ZA-4000 Durban, South Africa.
EM gamede25@live.com
RI Khathi, Andile/S-9664-2019
OI Khathi, Andile/0000-0002-2246-0038; Gamede, Mlindeli/0000-0001-5512-1545
FU National Research Foundation (South Africa) [106041]
FX The authors disclosed receipt of the following financial support for the
   research, authorship, and/or publication of this article: National
   Research Foundation (South Africa) for financial support (grant number
   106041)
CR Adams RA, 2004, MOL INTERV, V4, P163
   Adeva-Andany MM, 2016, BBA CLIN, V5, P85, DOI 10.1016/j.bbacli.2016.02.001
   Apostolopoulos V, 2016, MOL NUTR FOOD RES, V60, P43, DOI 10.1002/mnfr.201500272
   Bailey CJ, 2015, CLIN PHARMACOL THER, V98, P170, DOI 10.1002/cpt.144
   Bluher M, 2016, CLIN SCI, V130, P1603, DOI 10.1042/CS20160005
   Moreira APB, 2012, BRIT J NUTR, V108, P801, DOI 10.1017/S0007114512001213
   Calder PC, 2011, EUR J PHARMACOL, V668, pS50, DOI 10.1016/j.ejphar.2011.05.085
   Chang YY, 2019, INFLAMMOPHARMACOLOGY, V27, P249, DOI 10.1007/s10787-019-00568-7
   Chen K, 2008, CIRC RES, V102, P1512, DOI 10.1161/CIRCRESAHA.108.172064
   Chen SH, 2015, DIGEST LIVER DIS, V47, P226, DOI 10.1016/j.dld.2014.11.015
   Cho HM, 2015, YONSEI MED J, V56, P921, DOI 10.3349/ymj.2015.56.4.921
   Choi HC, 2013, NUTRITION, V29, P1110, DOI 10.1016/j.nut.2013.02.015
   Croft M, 2017, NAT REV RHEUMATOL, V13, P217, DOI 10.1038/nrrheum.2017.22
   Del Giudice M, 2018, BRAIN BEHAV IMMUN, V70, P61, DOI 10.1016/j.bbi.2018.02.013
   Elkon K.B., 2019, DUBOISLUPUS ERYTHEMA, P93, DOI DOI 10.1016/B978-0-323-47927-1.00008-6
   Gamede M, 2019, DIABETES METAB SYNDR, V12, P1953, DOI 10.2147/DMSO.S218626
   Gamede M, 2019, MOLECULES, V24, DOI 10.3390/molecules24020340
   Gamede M, 2018, MOLECULES, V23, DOI 10.3390/molecules23040794
   Gao YQ, 2017, MOL METAB, V6, P897, DOI 10.1016/j.molmet.2017.06.008
   Glaros Trevor G, 2013, Front Biosci (Schol Ed), V5, P754
   Grandl G, 2018, SEMIN IMMUNOPATHOL, V40, P215, DOI 10.1007/s00281-017-0666-5
   Graves DT, 2008, FRONT BIOSCI-LANDMRK, V13, P1227, DOI 10.2741/2757
   Hansen HH., 2019, TRANSLATIONAL RES ME, P369
   Helvaci MR, 2018, WORLD FAM MED, V16, P12, DOI 10.5742/MEWFM.2018.93305
   Kang YE, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0154003
   Kashyap D, 2016, RECENT PATENTS INFLA, V10, P21, DOI 10.2174/1872213X10666160711143904
   Keles S, 2016, J ALLERGY CLIN IMMUN, V138, P1384, DOI 10.1016/j.jaci.2016.04.023
   Khathi A, 2015, ENDOCRINOL ABS, DOI DOI 10.1530/ENDOABS.38.P224
   Khathi A, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0081632
   Kilciler G, 2010, UPSALA J MED SCI, V115, P253, DOI 10.3109/03009734.2010.500062
   Knudsen SH, 2015, CURR DIABETES REP, V15, DOI 10.1007/s11892-015-0642-1
   Kopec AK, 2017, J HEPATOL, V66, P787, DOI 10.1016/j.jhep.2016.12.004
   Koupenova M, 2018, CIRC RES, V122, P337, DOI 10.1161/CIRCRESAHA.117.310795
   Larson P, 2017, ACS MED CHEM LETT, V8, P1148, DOI 10.1021/acsmedchemlett.7b00256
   Lee SY, 2017, J IMMUNOL, V198, P2661, DOI 10.4049/jimmunol.1403088
   Li M, 2015, EVID-BASED COMPL ALT, V2015, DOI 10.1155/2015/643102
   Luo HQ, 2017, ACTA BIOCH BIOPH SIN, V49, P349, DOI 10.1093/abbs/gmx013
   Meza C, 2017, INT J EXERCISE SCI C, V2
   Roman-Pintos LM, 2016, J DIABETES RES, V2016, DOI 10.1155/2016/3425617
   Miki C, 2004, DIGEST DIS SCI, V49, P970, DOI 10.1023/B:DDAS.0000034556.48527.6e
   Milic S, 2014, WORLD J GASTROENTERO, V20, P9330, DOI 10.3748/wjg.v20.i28.9330
   Mohamed Jamaludin, 2016, Sultan Qaboos Univ Med J, V16, pe132, DOI 10.18295/squmj.2016.16.02.002
   Monea A, 2017, AUSTRALAS MED J, V10, P550, DOI 10.21767/AMJ.2017.3053
   Mzimela NC, 2019, AUTOIMMUNITY, V52, P27, DOI 10.1080/08916934.2019.1575820
   Neeland IJ, 2012, JAMA-J AM MED ASSOC, V308, P1150, DOI 10.1001/2012.jama.11132
   Osunsanmi FO, 2016, TROP J PHARM RES, V15, P1613, DOI 10.4314/tjpr.v15i8.3
   Parillaud VR, 2017, J NEUROINFLAMM, V14, DOI 10.1186/s12974-017-0830-9
   Pillon NJ, 2018, J LIPID RES, V59, P1148, DOI 10.1194/jlr.M080788
   Pollack RM, 2016, DIABETES CARE, V39, pS244, DOI 10.2337/dcS15-3015
   Pollak M, 2017, DIABETOLOGIA, V60, P1662, DOI 10.1007/s00125-017-4352-x
   Punthakee Z, 2018, CAN J DIABETES, V42, pS10, DOI 10.1016/j.jcjd.2017.10.003
   Rahimi RA, 2018, ADV IMMUNOL, V138, P71, DOI 10.1016/bs.ai.2018.02.002
   Rothhammer V, 2016, CURR OPIN IMMUNOL, V43, P46, DOI 10.1016/j.coi.2016.09.002
   Santilli F., 2019, PLATELETS, P469, DOI DOI 10.1016/B978-0-12-813456-6.00027-8
   Schuiveling M, 2018, CURR DRUG TARGETS, V19, P945, DOI 10.2174/1389450118666170613081730
   Siegel-Axel D, 2008, CARDIOVASC RES, V78, P8, DOI 10.1093/cvr/cvn015
   Simeone P, 2018, NUTRIENTS, V10, DOI 10.3390/nu10121872
   Sproston NR, 2018, FRONT IMMUNOL, V9, DOI 10.3389/fimmu.2018.00754
   Tall AR, 2015, NAT REV IMMUNOL, V15, P104, DOI 10.1038/nri3793
   Thomas BJ, 2016, AM J RESP CELL MOL, V55, P759, DOI 10.1165/rcmb.2016-0248PS
   Tilg H, 2015, GASTROENTEROLOGY, V148, P1107, DOI 10.1053/j.gastro.2014.12.036
   Tramullas M, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0155367
   Wang A, 2019, SCIENCE, V363, P140, DOI 10.1126/science.aar3932
   Willecke F, 2017, CARD VASC BIOL, P137, DOI 10.1007/978-3-319-66224-4_9
   Xu HY, 2003, J CLIN INVEST, V112, P1821, DOI 10.1172/JCI200319451
   Yaribeygi H, 2019, J CELL PHYSIOL, V234, P8286, DOI 10.1002/jcp.27699
   Zhang X, 2017, MEDICINE, V96, DOI 10.1097/MD.0000000000006694
NR 67
TC 4
Z9 4
U1 1
U2 7
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 2042-0188
EI 2042-0196
J9 THER ADV ENDOCRINOL
JI Ther. Adv. Endocrinol. Metab.
PD JUL
PY 2020
VL 11
AR 2042018820935771
DI 10.1177/2042018820935771
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA MZ4CV
UT WOS:000559070300001
PM 32782775
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Wu, QF
   Wu, SY
   Cheng, Y
   Zhang, ZS
   Mao, GX
   Li, SJ
   Yang, Y
   Zhang, X
   Wu, MJ
   Tong, HB
AF Wu, Qifang
   Wu, Siya
   Cheng, Yang
   Zhang, Zhongshan
   Mao, Genxiang
   Li, Shijun
   Yang, Yue
   Zhang, Xu
   Wu, Mingjiang
   Tong, Haibin
TI Sargassum fusiforme fucoidan modifies gut microbiota and intestinal
   metabolites during alleviation of hyperglycemia in type 2 diabetic mice
SO FOOD & FUNCTION
LA English
DT Article
ID HIGH-FAT DIET; CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS; INDUCED
   OBESITY; POLYSACCHARIDES; CARNITINE; METFORMIN; MORTALITY; SULFONYLUREA;
   ASSOCIATION
AB Type 2 diabetic mellitus (T2DM) is a complicated metabolic disorder that is now considered as a major global public health problem. Fucoidan exhibits diverse biological activities, especially prevention of metabolic diseases. In this regard, we herein aimed to reveal the beneficial effect of Sargassum fusiforme fucoidan (SFF) on high-fat diet (HFD) and streptozotocin (STZ) induced T2DM mice. We noted that on the one hand, SFF significantly decreased fasting blood glucose, diet and water intake, and hyperlipidemia, while on the other hand, it improved glucose tolerance. Furthermore, SFF reduced epididymal fat deposition, attenuated the pathological changes in heart and liver tissues, and decreased oxidative stress in diabetic mice. To explore the underlying mechanisms of these ameliorative effects, the gut microbiota was analyzed. Notably, SFF highly enriched benign microbes including Bacteroides, Faecalibacterium and Blautia, as well as increased levels of (R)-carnitine and choline in the colon of diabetic mice. This may be a potential mechanism for alleviating T2DM, thus implying the benefits of SFF as an adjuvant agent for T2DM treatment. Taken together, this study demonstrated a promising application of fucoidan as one of the adjuvant agents for the management of T2DM in the future.
C1 [Wu, Qifang; Wu, Siya; Cheng, Yang; Li, Shijun; Yang, Yue; Zhang, Xu; Wu, Mingjiang; Tong, Haibin] Wenzhou Univ, Coll Life & Environm Sci, Wenzhou 325035, Peoples R China.
   [Zhang, Zhongshan] Huzhou Univ, Key Lab Vector Biol & Pathogen Control Zhejiang P, Huzhou Cent Hosp, Huzhou 313000, Peoples R China.
   [Mao, Genxiang] Zhejiang Hosp, Dept Geriatr, Zhejiang Prov Key Lab Geriatr, Hangzhou 310013, Peoples R China.
C3 Wenzhou University; Huzhou University
RP Wu, MJ; Tong, HB (通讯作者)，Wenzhou Univ, Coll Life & Environm Sci, Wenzhou 325035, Peoples R China.
EM wmj@wzu.edu.cn; tonghaibin@gmail.com
RI Liu, Jian/IQS-8197-2023; Li, Xiaomei/HNI-0635-2023; li,
   xiao/HKV-8405-2023; Zhang, Zhongshan/GRE-8458-2022; Zhang,
   Yiyang/HZI-3668-2023; wang, yue/ISA-4119-2023; zhang, yu/HNS-5948-2023;
   Liu, Han/HMD-9231-2023; Li, Li/IAQ-0885-2023
OI Zhang, Zhongshan/0000-0003-4991-0016; Liu, Han/0000-0002-5269-8477; 
FU National Natural Science Foundation of China [81872952, 41876197];
   National Key Research and Development Project [2018YFD0901503]; Natural
   Science Foundation of Zhejiang Province [LY18C020006]; Science and
   Technology Program of Wenzhou [ZY2019013]
FX This work was financially supported by the National Natural Science
   Foundation of China (81872952 and 41876197), the National Key Research
   and Development Project (2018YFD0901503), the Natural Science Foundation
   of Zhejiang Province (LY18C020006) and the Science and Technology
   Program of Wenzhou (ZY2019013).
CR Abdul-Ghani MA, 2009, DIABETES CARE, V32, pS194, DOI 10.2337/dc09-S309
   Ale MT, 2011, MAR DRUGS, V9, P2106, DOI 10.3390/md9102106
   Babidge W, 1998, MOL CELL BIOCHEM, V181, P117, DOI 10.1023/A:1006838231432
   Bene J, 2018, NUTR DIABETES, V8, DOI 10.1038/s41387-018-0017-1
   Blandino G, 2016, DIABETES METAB, V42, P303, DOI 10.1016/j.diabet.2016.04.004
   Tonucci L, 2017, CRIT REV FOOD SCI, V57, P2296, DOI 10.1080/10408398.2014.934438
   Britton KA, 2011, CIRCULATION, V124, pE837, DOI 10.1161/CIRCULATIONAHA.111.077602
   Candela M, 2016, BRIT J NUTR, V116, P80, DOI 10.1017/S0007114516001045
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Cani PD, 2007, CURR OPIN CLIN NUTR, V10, P729, DOI 10.1097/MCO.0b013e3282efdebb
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   Cao Y, 2019, J DIABETES RES, V2019, DOI 10.1155/2019/1872134
   Chen BJ, 2016, INT J BIOL MACROMOL, V92, P715, DOI 10.1016/j.ijbiomac.2016.07.082
   Chen XM, 2012, FOOD CHEM TOXICOL, V50, P695, DOI 10.1016/j.fct.2011.11.015
   Cheng Y, 2019, INT J BIOL MACROMOL, V131, P1162, DOI 10.1016/j.ijbiomac.2019.04.040
   Dandona P, 2004, TRENDS IMMUNOL, V25, P4, DOI 10.1016/j.it.2003.10.013
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   DeFronzo RA, 2015, NAT REV DIS PRIMERS, V1, DOI 10.1038/nrdp.2015.19
   den Besten G, 2013, J LIPID RES, V54, P2325, DOI 10.1194/jlr.R036012
   Dumas ME, 2006, P NATL ACAD SCI USA, V103, P12511, DOI 10.1073/pnas.0601056103
   Eckel RH, 2011, J CLIN ENDOCR METAB, V96, P1654, DOI 10.1210/jc.2011-0585
   Elmarakby AA, 2012, CARDIOVASC THER, V30, P49, DOI 10.1111/j.1755-5922.2010.00218.x
   Evans JL, 2003, DIABETES, V52, P1, DOI 10.2337/diabetes.52.1.1
   Fu XD, 2019, CRIT REV FOOD SCI, V59, pS130, DOI 10.1080/10408398.2018.1542587
   Gao X, 2015, FOOD FUNCT, V6, P1117, DOI 10.1039/c5fo00007f
   GARCIA MJ, 1974, DIABETES, V23, P105, DOI 10.2337/diab.23.2.105
   Gilbert ER, 2011, EXP DIABETES RES, DOI 10.1155/2011/416254
   Gravitz L, 2012, NATURE, V485, pS12, DOI 10.1038/485S12a
   Gurung M, 2020, EBIOMEDICINE, V51, DOI 10.1016/j.ebiom.2019.11.051
   He CX, 2015, NUTR RES, V35, P361, DOI 10.1016/j.nutres.2015.03.002
   Inan MS, 2000, GASTROENTEROLOGY, V118, P724, DOI 10.1016/S0016-5085(00)70142-9
   Jakobsson HE, 2015, EMBO REP, V16, P164, DOI 10.15252/embr.201439263
   Jeong MY, 2019, NEUROSCI LETT, V698, P51, DOI 10.1016/j.neulet.2019.01.006
   Jiang Jieying, 2013, Prev Med, V57, P60, DOI 10.1016/j.ypmed.2013.04.014
   KANNEL WB, 1979, JAMA-J AM MED ASSOC, V241, P2035, DOI 10.1001/jama.241.19.2035
   Kenchaiah S, 2002, NEW ENGL J MED, V347, P305, DOI 10.1056/NEJMoa020245
   Kerru N, 2018, EUR J MED CHEM, V152, P436, DOI 10.1016/j.ejmech.2018.04.061
   Kim KA, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0047713
   Kinoshita M, 2002, BIOCHEM BIOPH RES CO, V293, P827, DOI 10.1016/S0006-291X(02)00294-2
   Koeth RA, 2013, NAT MED, V19, P576, DOI 10.1038/nm.3145
   Koh HSA, 2020, FRONT PHARMACOL, V11, DOI 10.3389/fphar.2020.00831
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Lenzen S, 2008, DIABETOLOGIA, V51, P216, DOI 10.1007/s00125-007-0886-7
   Levelt E, 2016, J AM COLL CARDIOL, V68, P53, DOI 10.1016/j.jacc.2016.03.597
   Li B, 2008, MOLECULES, V13, P1671, DOI 10.3390/molecules13081671
   Li XL, 2012, EXP BIOL MED, V237, P1310, DOI 10.1258/ebm.2012.012157
   Lin H, 2016, SCI REP-UK, V6, DOI 10.1038/srep21618
   Liu RX, 2017, NAT MED, V23, P859, DOI 10.1038/nm.4358
   Long SL, 2017, MOL ASPECTS MED, V56, P54, DOI 10.1016/j.mam.2017.06.002
   Loubinoux J, 2000, J CLIN MICROBIOL, V38, P931, DOI 10.1128/JCM.38.2.931-934.2000
   Luo J, 1998, METABOLISM, V47, P663, DOI 10.1016/S0026-0495(98)90027-0
   Ma QT, 2019, BIOMED PHARMACOTHER, V117, DOI 10.1016/j.biopha.2019.109138
   Martel J, 2017, NAT REV ENDOCRINOL, V13, P149, DOI 10.1038/nrendo.2016.142
   Martinez-Guryn K, 2018, CELL HOST MICROBE, V23, P458, DOI 10.1016/j.chom.2018.03.011
   Munukka E, 2012, OBESITY, V20, P1082, DOI 10.1038/oby.2012.8
   Ng JSY, 2012, MOL BIOCHEM PARASIT, V185, P145, DOI 10.1016/j.molbiopara.2012.08.006
   Nie QX, 2019, FOOD HYDROCOLLOID, V86, P34, DOI 10.1016/j.foodhyd.2017.12.026
   Oliphant K, 2019, MICROBIOME, V7, DOI 10.1186/s40168-019-0704-8
   Pan YX, 2017, CARBOHYD POLYM, V164, P370, DOI 10.1016/j.carbpol.2017.01.092
   Petruzzelli M, 2010, CELL METAB, V11, P345, DOI 10.1016/j.cmet.2010.04.012
   Puddu Alessandra, 2014, Mediators Inflamm, V2014, P162021, DOI 10.1155/2014/162021
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Rankin LC, 2018, CELL, V173, P554, DOI 10.1016/j.cell.2018.03.013
   Rath S, 2017, MICROBIOME, V5, DOI 10.1186/s40168-017-0271-9
   Ringseis R, 2012, EUR J NUTR, V51, P1, DOI 10.1007/s00394-011-0284-2
   Romano KA, 2015, MBIO, V6, DOI 10.1128/mBio.02481-14
   Roumie CL, 2012, ANN INTERN MED, V157, P601, DOI 10.7326/0003-4819-157-9-201211060-00003
   Saeedi P, 2019, DIABETES RES CLIN PR, V157, DOI 10.1016/j.diabres.2019.107843
   Sangster T, 2006, ANALYST, V131, P1075, DOI 10.1039/b604498k
   Shang QS, 2016, FOOD FUNCT, V7, P3224, DOI [10.1039/C6FO00309E, 10.1039/c6fo00309e]
   Simpson SH, 2006, CAN MED ASSOC J, V174, P169, DOI 10.1503/cmaj.050748
   Srinivasan K, 2007, INDIAN J MED RES, V125, P451
   Van Hul M, 2018, AM J PHYSIOL-ENDOC M, V314, pE334, DOI 10.1152/ajpendo.00107.2017
   Vijay-Kumar M, 2010, SCIENCE, V328, P228, DOI 10.1126/science.1179721
   Wagner M, 1998, J BACTERIOL, V180, P2975, DOI 10.1128/JB.180.11.2975-2982.1998
   Wang ZN, 2011, NATURE, V472, P57, DOI 10.1038/nature09922
   Weglarz L, 2003, CELL MOL BIOL LETT, V8, P991
   Wu SY, 2019, INT J BIOL MACROMOL, V133, P656, DOI 10.1016/j.ijbiomac.2019.03.218
   Wu TR, 2019, GUT, V68, P248, DOI 10.1136/gutjnl-2017-315458
   Wu XD, 2014, FOOD CHEM, V145, P976, DOI 10.1016/j.foodchem.2013.09.019
   Yan HL, 2017, PHYTOMEDICINE, V26, P45, DOI 10.1016/j.phymed.2017.01.007
   Yu J, 2009, FOOD CHEM, V117, P42, DOI 10.1016/j.foodchem.2009.03.073
   Yu P, 2014, CARBOHYD POLYM, V99, P278, DOI 10.1016/j.carbpol.2013.08.033
   Zhang XY, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0071108
   Zhang X, 2015, SCI REP-UK, V5, DOI 10.1038/srep14405
   Zhang Y, 2020, J AGR FOOD CHEM, V68, P10626, DOI 10.1021/acs.jafc.0c02555
NR 86
TC 21
Z9 21
U1 13
U2 82
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD APR 21
PY 2021
VL 12
IS 8
BP 3572
EP 3585
DI 10.1039/d0fo03329d
EA MAR 2021
PG 14
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA RS9EI
UT WOS:000634724500001
PM 33900346
DA 2023-06-08
ER

PT J
AU Nguyen, T
   Gong, M
   Wen, S
   Yuan, XL
   Wang, CX
   Jin, JL
   Zhou, LG
AF Nguyen, Thiquynhnga
   Gong, Min
   Wen, Song
   Yuan, Xinlu
   Wang, Chaoxun
   Jin, Jianlan
   Zhou, Ligang
TI The Mechanism of Metabolic Influences on the Endogenous GLP-1 by Oral
   Antidiabetic Medications in Type 2 Diabetes Mellitus
SO JOURNAL OF DIABETES RESEARCH
LA English
DT Review
ID GLUCAGON-LIKE PEPTIDE-1; PANCREATIC BETA-CELLS; METFORMIN TREATMENT;
   GLUCOSE-PRODUCTION; INSULIN-SECRETION; INCRETIN HORMONE; GUT MICROBIOTA;
   PLASMA-INSULIN; OBESE-PATIENTS; LIRAGLUTIDE
AB Incretin-based therapy is now a prevalent treatment option for patients with type 2 diabetes mellitus (T2DM). It has been associated with considerably good results in the management of hyperglycemia with cardiac or nephron-benefits. For this reason, it is recommended for individuals with cardiovascular diseases in many clinical guidelines. As an incretin hormone, glucagon-like peptide-1 (GLP-1) possesses multiple metabolic benefits such as optimizing energy usage, maintaining body weight,beta cell preservation, and suppressing neurodegeneration. However, recent studies indicate that oral antidiabetic medications interact with endogenous or exogenous GLP-1. Since these drugs are transported to distal intestine portions, there are concerns whether these oral drugs directly stimulate intestinal L cells which release GLP-1, or whether they do so via indirect inhibition of the activity of dipeptidyl peptidase-IV (DPP-IV). In this review, we discuss the metabolic relationships between oral antihyperglycemic drugs from the aspect of gut, microbiota, hormones,beta cell function, central nervous system, and other cellular mechanisms.
C1 [Nguyen, Thiquynhnga; Gong, Min; Wen, Song; Yuan, Xinlu; Wang, Chaoxun; Jin, Jianlan; Zhou, Ligang] Fudan Univ, Shanghai Pudong Hosp, Dept Endocrinol, Shanghai 201399, Peoples R China.
C3 Fudan University
RP Zhou, LG (通讯作者)，Fudan Univ, Shanghai Pudong Hosp, Dept Endocrinol, Shanghai 201399, Peoples R China.
EM 2714618016@qq.com; gongmin9808@126.com; 379295093@qq.com;
   yuanxinlu1982@126.com; xunshdonger@hotmail.com; 1124292719@qq.com;
   zhouligang@yahoo.com
OI Wen, Song/0000-0001-6173-0507
FU National Natural Science Foundation of China [81370932]; United States
   MERCK IISP Fund [40313, 40309]; Outstanding Leaders Training Program of
   Pudong Health Bureau of Shanghai [PWR12014-06]; Integrative Medicine
   special fund of Shanghai Municipal Health Planning Committee
   [ZHYY-ZXYJHZX-2-201712]; Key studies (special) Department Fund of the
   Pudong New Area Health Planning Commission [PWZzk2017-03]
FX This work was funded by the National Natural Science Foundation of China
   (No. 81370932), the United States MERCK IISP Fund (No. 40313 and No.
   40309), the Outstanding Leaders Training Program of Pudong Health Bureau
   of Shanghai (Grant No. PWR12014-06), the Integrative Medicine special
   fund of Shanghai Municipal Health Planning Committee (No.
   ZHYY-ZXYJHZX-2-201712), and the Key studies (special) Department Fund of
   the Pudong New Area Health Planning Commission (No. PWZzk2017-03).
CR Adrian TE, 2012, DIABETOLOGIA, V55, P2343, DOI 10.1007/s00125-012-2593-2
   ADRIAN TE, 1993, GUT, V34, P1219, DOI 10.1136/gut.34.9.1219
   Ahn CH, 2018, DIABETES OBES METAB, V20, P370, DOI 10.1111/dom.13081
   Anderluh M, 2019, PHARMACOL THERAPEUT, V201, P1, DOI 10.1016/j.pharmthera.2019.05.007
   Baggio LL, 2007, GASTROENTEROLOGY, V132, P2131, DOI 10.1053/j.gastro.2007.03.054
   Bronden A, 2017, J CLIN ENDOCR METAB, V102, P4153, DOI 10.1210/jc.2017-01091
   Campbell JE, 2013, CELL METAB, V17, P819, DOI 10.1016/j.cmet.2013.04.008
   Chen LH, 2012, AM J PHYSIOL-ENDOC M, V302, pE68, DOI 10.1152/ajpendo.00323.2011
   Daniels SJ, 2019, BIOMED PHARMACOTHER, V111, P926, DOI 10.1016/j.biopha.2018.12.130
   de Heer J, 2007, DIABETES, V56, P438, DOI 10.2337/db06-0738
   Decara J, 2016, BIOFACTORS, V42, P600, DOI 10.1002/biof.1295
   den Besten G, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0136364
   DIABHYCAR Study Group Italian Repaglinide Study Group DPV-Wiss-Study Group KANWU Study Group 205-Nations Study Group AT.LANTUS Study Group Fidarestat Study Group North West Adelaide Health Study Team AT:LANTUS Study Group Euro Heart Survey Investigators The FinnDiane Study Group AUDIT Investigators DPV-Wiss-Study Group KORA Group Spanish Group of MODY (GEM) Israel Diabetes Research Group (IDRG) IMDIAB Group IMDIAB G. Belgian Diabetes Registry (Brussels Belgium) The RECORD Study Group HOE901/4009 Study Group Turkish Diabetes Centers Study Group The ASDIAB Study Group EURODIAB PCS Group FinnDiane Study Group, 2004, DIABETOLOGIA S1, V47, pA1, DOI [10.1007/BF03375463, DOI 10.1007/BF03375463]
   Do HJ, 2016, ENDOCR J, V63, P691, DOI 10.1507/endocrj.EJ15-0747
   Duca FA, 2015, NAT MED, V21, P506, DOI 10.1038/nm.3787
   ELRICK H, 1964, J CLIN ENDOCR METAB, V24, P1076, DOI 10.1210/jcem-24-10-1076
   Erdogan MA, 2018, BMC NEUROL, V18, DOI 10.1186/s12883-018-1086-4
   Farr OM, 2016, METABOLISM, V65, P945, DOI 10.1016/j.metabol.2016.03.009
   Ferrannini E, 2014, J CLIN INVEST, V124, P499, DOI 10.1172/JCI72227
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Gupta S, 2019, PHARMACOL RES, V147, DOI 10.1016/j.phrs.2019.104391
   Hauner H, 2002, DIABETES-METAB RES, V18, pS10, DOI 10.1002/dmrr.249
   Heerspink HJL, 2016, CIRCULATION, V134, P752, DOI 10.1161/CIRCULATIONAHA.116.021887
   Henquin JC, 2017, BIOCHIMIE, V143, P3, DOI 10.1016/j.biochi.2017.07.002
   Holst JJ, 2007, PHYSIOL REV, V87, P1409, DOI 10.1152/physrev.00034.2006
   Holz GG, 2004, DIABETES, V53, P5, DOI 10.2337/diabetes.53.1.5
   Hundal RS, 2000, DIABETES, V49, P2063, DOI 10.2337/diabetes.49.12.2063
   Iepsen EW, 2015, INT J OBESITY, V39, P834, DOI 10.1038/ijo.2014.177
   International Diabetes Federation, 2017, IDF DIAB ATL 2021, V8th
   Irwin N, 2011, HORM METAB RES, V43, P244, DOI 10.1055/s-0030-1269897
   Joshi SR, 2015, EXPERT OPIN PHARMACO, V16, P597, DOI 10.1517/14656566.2015.1009894
   Kimura T, 2015, MOL CELL ENDOCRINOL, V400, P78, DOI 10.1016/j.mce.2014.11.018
   Krentz AJ, 2005, DRUGS, V65, P385, DOI 10.2165/00003495-200565030-00005
   Kyriachenko Y, 2019, WORLD J DIABETES, V10, P154, DOI 10.4239/wjd.v10.i3.154
   Lee DM, 2018, CARDIOVASC DIABETOL, V17, DOI 10.1186/s12933-018-0708-x
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Lenhard JM, 2004, BIOCHEM BIOPH RES CO, V324, P92, DOI 10.1016/j.bbrc.2004.09.021
   Maida A, 2011, DIABETOLOGIA, V54, P339, DOI 10.1007/s00125-010-1937-z
   Mannucci E, 2004, DIABETES NUTR METAB, V17, P336
   Mannucci E, 2001, DIABETES CARE, V24, P489, DOI 10.2337/diacare.24.3.489
   McCarty MF, 2015, OPEN HEART, V2, DOI 10.1136/openhrt-2014-000205
   McCreight LJ, 2016, DIABETOLOGIA, V59, P426, DOI 10.1007/s00125-015-3844-9
   Meloni AR, 2013, DIABETES OBES METAB, V15, P15, DOI 10.1111/j.1463-1326.2012.01663.x
   Millar P, 2017, J ENDOCRINOL, V234, P255, DOI 10.1530/JOE-17-0263
   Miura H, 2019, J DIABETES INVEST, V10, P1254, DOI 10.1111/jdi.13015
   Mulherin AJ, 2011, ENDOCRINOLOGY, V152, P4610, DOI 10.1210/en.2011-1485
   Musi N, 2003, ACTA PHYSIOL SCAND, V178, P337, DOI 10.1046/j.1365-201X.2003.01168.x
   Napolitano A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100778
   Naznin F, 2017, EUR J PHARMACOL, V794, P37, DOI 10.1016/j.ejphar.2016.11.028
   Nunez DJ, 2016, DIABETES OBES METAB, V18, P654, DOI 10.1111/dom.12656
   Preiss D, 2017, DIABETES OBES METAB, V19, P356, DOI 10.1111/dom.12826
   Rahmoune H, 2005, DIABETES, V54, P3427, DOI 10.2337/diabetes.54.12.3427
   Scarpello JHB, 1998, DIABETIC MED, V15, P651, DOI 10.1002/(SICI)1096-9136(199808)15:8<651::AID-DIA628>3.0.CO;2-A
   Seino S, 2017, DIABETES OBES METAB, V19, P22, DOI 10.1111/dom.12995
   Serej ZA, 2017, BIOMED PHARMACOTHER, V91, P88, DOI 10.1016/j.biopha.2017.04.074
   Srinivasan S, 2018, DIABETES CARE, V41, P554, DOI 10.2337/dc17-1386
   Tahrani AA, 2016, NAT REV ENDOCRINOL, V12, P566, DOI 10.1038/nrendo.2016.86
   Takahashi H, 2015, DIABETES, V64, P1262, DOI 10.2337/db14-0576
   Takebayashi K, 2017, ENDOCR J, V64, P923, DOI 10.1507/endocrj.EJ17-0065
   Tanaka M, 2019, CURR HYPERTENS REP, V21, DOI 10.1007/s11906-019-0964-5
   Tasanen K, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.01238
   Julian MT, 2016, MOL CELL ENDOCRINOL, V426, P101, DOI 10.1016/j.mce.2016.02.014
   Thomas C, 2009, CELL METAB, V10, P167, DOI 10.1016/j.cmet.2009.08.001
   Thondam SK, 2012, DIABETIC MED, V29, pE205, DOI 10.1111/j.1464-5491.2012.03675.x
   Tolhurst G, 2012, DIABETES, V61, P364, DOI 10.2337/db11-1019
   Trabelsi MS, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms8629
   Ueno H, 2015, DIABETES THER, V6, P187, DOI 10.1007/s13300-015-0113-3
   Vardarli I, 2014, DIABETES, V63, P663, DOI 10.2337/db13-0805
   Vieira ELM, 2012, J NUTR BIOCHEM, V23, P430, DOI 10.1016/j.jnutbio.2011.01.007
   Wang LM, 2017, JAMA-J AM MED ASSOC, V317, P2515, DOI 10.1001/jama.2017.7596
   Wolever TMS, 2000, BRIT J NUTR, V84, P57
   Yki-Jarvinen H, 2004, NEW ENGL J MED, V351, P1106, DOI 10.1056/NEJMra041001
   Zhang JP, 2016, J DIABETES, V8, P559, DOI 10.1111/1753-0407.12337
   Zheng J, 2017, NUTRITION, V39-40, P82, DOI 10.1016/j.nut.2017.01.002
NR 74
TC 2
Z9 3
U1 1
U2 8
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6745
EI 2314-6753
J9 J DIABETES RES
JI J. Diabetes Res.
PD JUN 18
PY 2020
VL 2020
AR 4727390
DI 10.1155/2020/4727390
PG 11
WC Endocrinology & Metabolism; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Research & Experimental Medicine
GA MG5MU
UT WOS:000546076900001
PM 32656265
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Yue, CB
   Chu, CQ
   Zhao, JX
   Zhang, H
   Chen, W
   Zhai, QX
AF Yue, Chenbo
   Chu, Chuanqi
   Zhao, Jianxin
   Zhang, Hao
   Chen, Wei
   Zhai, Qixiao
TI Dietary strategies to promote the abundance of intestinal Akkermansia
   muciniphila, a focus on the effect of plant extracts
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Plant extracts; Dietary strategies; Next-generation probiotics;
   Abundance; Akkermansia muciniphila; Mechanism
ID GUT MICROBIOTA; INSULIN-RESISTANCE; HEPATIC STEATOSIS; INDUCED OBESITY;
   MICE; POLYPHENOLS; METFORMIN; GLUCOSE; HEALTH; MUCIN
AB As the next generation of probiotics, Akkermansia muciniphila has attracted a lot of attention and research because of its probiotic properties. However, it is not on the list of strains that can be added to food in any country, and its sensitivity to oxygen and the availability of animal-derived media limit its industrial production. Alternative dietary intervention strategies have broad application prospects. This review uses plant extracts as the main framework to summarize studies on increasing the abundance of A. muciniphila in recent years. Polyphenols, alkaloids, capsaicin, plant-derived carbohydrates, and some Chinese medicines can significantly increase the abundance of A. muciniphila in the gut. Promoting the abundance of A. muciniphila's mechanisms focused on promoting the secretion of mucins and their antibacterial ability. This paper provides a lot of theoretical basics for the development of dietary strategies that can improve intestinal A. muciniphila abundance in the future.
C1 [Yue, Chenbo; Chu, Chuanqi; Zhao, Jianxin; Zhang, Hao; Chen, Wei; Zhai, Qixiao] Jiangnan Univ, State Key Lab Food Sci & Technol, Wuxi 214122, Jiangsu, Peoples R China.
   [Yue, Chenbo; Chu, Chuanqi; Zhao, Jianxin; Zhang, Hao; Chen, Wei; Zhai, Qixiao] Jiangnan Univ, Sch Food Sci & Technol, Wuxi 214122, Jiangsu, Peoples R China.
   [Zhang, Hao; Chen, Wei] Jiangnan Univ, Natl Engn Res Ctr Funct Food, Wuxi 214122, Jiangsu, Peoples R China.
   [Zhang, Hao] Jiangsu Translat Med Res Inst Wuxi Branch, Wuxi Translat Med Res Ctr, Wuxi, Jiangsu, Peoples R China.
C3 Jiangnan University; Jiangnan University; Jiangnan University
RP Zhai, QX (通讯作者)，Jiangnan Univ, State Key Lab Food Sci & Technol, Wuxi 214122, Jiangsu, Peoples R China.
EM zhaiqixiao@sina.com
RI Chen, Wei/GZK-7348-2022; Zhang, Hao/HHM-1940-2022
FU Natural Science Foundation of Jiangsu Province [BK20200084]; National
   Natural Science Foun-dation of China [32001665, 31871773]; Collaborative
   Innovation Center of Food Safety and Quality Control in Jiangsu Province
FX Funding This work was supported by the Natural Science Foundation of
   Jiangsu Province (BK20200084) , the National Natural Science Foun-dation
   of China (No. 32001665 and No. 31871773) , and Collaborative Innovation
   Center of Food Safety and Quality Control in Jiangsu Province.
CR Al Khalaf AK, 2021, NUTRIENTS, V13, DOI 10.3390/nu13113885
   Alard J, 2016, ENVIRON MICROBIOL, V18, P1484, DOI 10.1111/1462-2920.13181
   Alrafas HR, 2019, J LEUKOCYTE BIOL, V106, P467, DOI 10.1002/JLB.3A1218-476RR
   Anhe FF, 2018, DIABETOLOGIA, V61, P919, DOI 10.1007/s00125-017-4520-z
   Anhe FF, 2017, MOL METAB, V6, P1563, DOI 10.1016/j.molmet.2017.10.003
   Anhe FF, 2015, GUT, V64, P872, DOI 10.1136/gutjnl-2014-307142
   Baboota RK, 2014, J NUTR BIOCHEM, V25, P893, DOI 10.1016/j.jnutbio.2014.04.004
   Bai YF, 2019, NUTR DIABETES, V9, DOI 10.1038/s41387-019-0097-6
   Barcena C, 2019, NAT MED, V25, P1234, DOI 10.1038/s41591-019-0504-5
   Burger-van Paassen N, 2009, BIOCHEM J, V420, P211, DOI 10.1042/BJ20082222
   Burokas A, 2017, BIOL PSYCHIAT, V82, P472, DOI 10.1016/j.biopsych.2016.12.031
   Cai YD, 2020, FOOD SCI HUM WELL, V9, P58, DOI 10.1016/j.fshw.2019.12.008
   Carey HV, 2013, AM J PHYSIOL-REG I, V304, pR33, DOI 10.1152/ajpregu.00387.2012
   Catry E, 2018, GUT, V67, P271, DOI 10.1136/gutjnl-2016-313316
   Chen KT, 2020, INT J FOOD SCI NUTR, V71, P965, DOI 10.1080/09637486.2020.1754351
   Chen MT, 2020, CLIN NUTR, V39, P1264, DOI 10.1016/j.clnu.2019.05.020
   Chen MY, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.02380
   Chen PY, 2019, J AGR FOOD CHEM, V67, P7869, DOI 10.1021/acs.jafc.9b03092
   Chen RZ, 2019, J NUTR BIOCHEM, V65, P101, DOI 10.1016/j.jnutbio.2018.12.004
   Chen Y, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.02307
   Choe U, 2020, FOOD SCI NUTR, V8, P1215, DOI 10.1002/fsn3.1410
   Daisley BA, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-18649-5
   Depommier C, 2019, NAT MED, V25, P1096, DOI 10.1038/s41591-019-0495-2
   Derrien M, 2004, INT J SYST EVOL MICR, V54, P1469, DOI 10.1099/ijs.0.02873-0
   Desai MS, 2016, CELL, V167, P1339, DOI 10.1016/j.cell.2016.10.043
   Ding YN, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.02800
   Dubourg G, 2013, INT J ANTIMICROB AG, V41, P149, DOI 10.1016/j.ijantimicag.2012.10.012
   Durazzo A, 2019, PHYTOTHER RES, V33, P2221, DOI 10.1002/ptr.6419
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Everard A, 2011, DIABETES, V60, P2775, DOI 10.2337/db11-0227
   Garcia-Mazcorro JF, 2018, PEERJ, V6, DOI 10.7717/peerj.4195
   Garcia-Villalba R, 2013, J AGR FOOD CHEM, V61, P8797, DOI 10.1021/jf402498b
   George NS, 2019, FOOD SCI NUTR, V7, P2565, DOI 10.1002/fsn3.1106
   Guan QQ, 2021, ENGINEERING-PRC, V7, P212, DOI 10.1016/j.eng.2020.03.018
   Gurley BJ, 2019, NUTRIENTS, V11, DOI 10.3390/nu11040776
   Halmos EP, 2015, GUT, V64, P93, DOI 10.1136/gutjnl-2014-307264
   Han F, 2018, J AGR FOOD CHEM, V66, P6326, DOI 10.1021/acs.jafc.8b01891
   Hansen CHF, 2012, DIABETOLOGIA, V55, P2285, DOI 10.1007/s00125-012-2564-7
   He K, 2016, BBA-MOL BASIS DIS, V1862, P1696, DOI 10.1016/j.bbadis.2016.06.006
   Henning SM, 2017, ANAEROBE, V43, P56, DOI 10.1016/j.anaerobe.2016.12.003
   Hsu CN, 2019, NUTRIENTS, V11, DOI 10.3390/nu11122908
   John OD, 2019, J FUNCT FOODS, V56, P204, DOI 10.1016/j.jff.2019.03.018
   Kemperman RA, 2013, FOOD RES INT, V53, P659, DOI 10.1016/j.foodres.2013.01.034
   Kleessen B, 2003, BRIT J NUTR, V89, P597, DOI 10.1079/BJN2002827
   Koistinen VM, 2019, MICROBIOME, V7, DOI 10.1186/s40168-019-0718-2
   Koutsoumanis K, 2020, EFSA J, V18, DOI 10.2903/j.efsa.2020.5966
   Lee H, 2018, GUT MICROBES, V9, P155, DOI 10.1080/19490976.2017.1405209
   Li CN, 2020, PHYTOTHER RES, V34, P1166, DOI 10.1002/ptr.6588
   Li F, 2020, FOOD FUNCT, V11, P1063, DOI [10.1039/c9fo01519a, 10.1039/C9FO01519A]
   Li JJ, 2020, J FUNCT FOODS, V75, DOI 10.1016/j.jff.2020.104246
   Li J, 2017, MICROBIOME, V5, DOI 10.1186/s40168-016-0222-x
   Li LY, 2020, GUT MICROBES, V11, P1348, DOI 10.1080/19490976.2020.1755413
   Li S, 2020, CLIN TRANSL MED, V10, DOI 10.1002/ctm2.112
   Li SY, 2021, J NUTR BIOCHEM, V93, DOI 10.1016/j.jnutbio.2021.108616
   Li ZP, 2015, FOOD FUNCT, V6, P2487, DOI [10.1039/C5FO00669D, 10.1039/c5fo00669d]
   Liu J, 2018, PHARMACOL RES, V134, P40, DOI 10.1016/j.phrs.2018.05.012
   Ma HT, 2019, INT J BIOL MACROMOL, V133, P1090, DOI 10.1016/j.ijbiomac.2019.04.209
   Masumoto S, 2016, SCI REP-UK, V6, DOI 10.1038/srep31208
   Monk JM, 2019, J NUTR BIOCHEM, V70, P91, DOI 10.1016/j.jnutbio.2019.04.009
   Morowitz MJ, 2017, CRIT CARE MED, V45, pE516, DOI [10.1097/ccm.0000000000002291, 10.1097/CCM.0000000000002291]
   Muniyandi K, 2019, FOOD SCI HUM WELL, V8, P73, DOI 10.1016/j.fshw.2019.03.005
   Nakano H, 2020, NUTRIENTS, V12, DOI 10.3390/nu12113252
   Nallathambi R, 2020, NUTRIENTS, V12, DOI 10.3390/nu12061623
   Neyrinck AM, 2017, MOL NUTR FOOD RES, V61, DOI 10.1002/mnfr.201500899
   Ottman N, 2017, BEST PRACT RES CL GA, V31, P637, DOI 10.1016/j.bpg.2017.10.001
   Ozkul C, 2019, TURK J GASTROENTEROL, V30, P1030, DOI 10.5152/tjg.2019.19185
   Pascale A, 2019, CURR OPIN PHARMACOL, V49, P1, DOI 10.1016/j.coph.2019.03.011
   Plovier H, 2017, NAT MED, V23, P107, DOI 10.1038/nm.4236
   Png CW, 2010, AM J GASTROENTEROL, V105, P2420, DOI 10.1038/ajg.2010.281
   Reunanen J, 2015, APPL ENVIRON MICROB, V81, P3655, DOI 10.1128/AEM.04050-14
   Ribo S, 2021, SCI TRANSL MED, V13, DOI 10.1126/scitranslmed.abb0322
   Roopchand DE, 2015, DIABETES, V64, P2847, DOI 10.2337/db14-1916
   Roshanravan N, 2017, J CARDIOVASC THORAC, V9, P183, DOI 10.15171/jcvtr.2017.32
   Routy B, 2018, SCIENCE, V359, P91, DOI 10.1126/science.aan3706
   Shang QS, 2017, J FUNCT FOODS, V28, P138, DOI 10.1016/j.jff.2016.11.002
   Shen W, 2017, FRONT MICROBIOL, V8, P1, DOI 10.3389/fmicb.2017.00272
   Sheng LL, 2018, FASEB J, V32, P6371, DOI 10.1096/fj.201800370R
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Song HZ, 2022, J SCI FOOD AGR, V102, P1968, DOI 10.1002/jsfa.11535
   Song HZ, 2021, NUTRITION, V86, DOI 10.1016/j.nut.2021.111176
   Song HZ, 2021, MOL NUTR FOOD RES, V65, DOI 10.1002/mnfr.202001090
   Sung MM, 2017, DIABETES, V66, P418, DOI 10.2337/db16-0680
   Teixeira C, 2018, MOL NUTR FOOD RES, V62, DOI 10.1002/mnfr.201701023
   Tian BM, 2021, MOL NUTR FOOD RES, V65, DOI 10.1002/mnfr.202000745
   Wang B, 2022, FRONT NUTR, V8, DOI 10.3389/fnut.2021.802352
   Wang FH, 2020, ACS OMEGA, V5, P1246, DOI 10.1021/acsomega.9b03798
   Wang JH, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0086117
   Wang JH, 2015, SCI REP-UK, V5, DOI 10.1038/srep08391
   Wang K, 2018, NUTRIENTS, V10, DOI 10.3390/nu10060791
   Wang L, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0218490
   Wang LJ, 2020, GUT, V69, P1988, DOI 10.1136/gutjnl-2019-320105
   Wang L, 2011, APPL ENVIRON MICROB, V77, P6718, DOI 10.1128/AEM.05212-11
   Wang YW, 2020, FOOD NUTR RES, V64, DOI 10.29219/fnr.v64.3525
   Wu T, 2020, FOOD RES INT, V128, DOI 10.1016/j.foodres.2019.108774
   Wu T, 2018, MOL NUTR FOOD RES, V62, DOI 10.1002/mnfr.201800607
   Wu Y, 2020, J AGR FOOD CHEM, V68, P11402, DOI 10.1021/acs.jafc.0c04119
   Xi ML, 2020, FOOD RES INT, V137, DOI 10.1016/j.foodres.2020.109288
   Yang JY, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0146144
   Zhai QX, 2019, CRIT REV FOOD SCI, V59, P3227, DOI 10.1080/10408398.2018.1517725
   Zhai XC, 2018, J AGR FOOD CHEM, V66, P12706, DOI 10.1021/acs.jafc.8b05036
   Zhang CG, 2019, FOOD SCI HUM WELL, V8, P102, DOI 10.1016/j.fshw.2019.03.007
   Zhang L, 2018, J NUTR BIOCHEM, V56, P142, DOI 10.1016/j.jnutbio.2018.02.009
   Zhang NN, 2018, MOLECULES, V23, DOI 10.3390/molecules23092188
   Zhang T, 2019, MICROB BIOTECHNOL, V12, P1109, DOI 10.1111/1751-7915.13410
   Zhang XW, 2019, J AGR FOOD CHEM, V67, P12796, DOI 10.1021/acs.jafc.9b06477
   Zhang YY, 2019, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.01929
   Zhang Z, 2017, NUTRIENTS, V9, DOI 10.3390/nu9070677
   Zhang Z, 2016, ONCOTARGET, V7, P31790, DOI 10.18632/oncotarget.9306
   Zheng XJ, 2018, FASEB J, V32, P4878, DOI 10.1096/fj.201700614R
   Zhou ZY, 2016, ACTA PHARMACOL SIN, V37, P1063, DOI 10.1038/aps.2016.21
   Zhu L, 2018, ATHEROSCLEROSIS, V268, P117, DOI 10.1016/j.atherosclerosis.2017.11.023
   Zhu W, 2020, BIOMED PHARMACOTHER, V121, DOI 10.1016/j.biopha.2019.109591
NR 112
TC 3
Z9 3
U1 14
U2 36
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD JUN
PY 2022
VL 93
AR 105093
DI 10.1016/j.jff.2022.105093
EA MAY 2022
PG 10
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA 1J8WZ
UT WOS:000798195300006
OA gold
DA 2023-06-08
ER

PT J
AU Partridge, L
   Fuentealba, M
   Kennedy, BK
AF Partridge, Linda
   Fuentealba, Matias
   Kennedy, Brian K.
TI The quest to slow ageing through drug discovery
SO NATURE REVIEWS DRUG DISCOVERY
LA English
DT Review
ID LIFE-SPAN EXTENSION; CALORIC RESTRICTION MIMETICS; GLUCOSE-LOWERING
   AGENTS; SENESCENT CELLS; CELLULAR SENESCENCE; RAPAMYCIN TREATMENT;
   ALZHEIMERS-DISEASE; NICOTINAMIDE RIBOSIDE; COGNITIVE FUNCTION; MAMMALIAN
   TARGET
AB Although death is inevitable, individuals have long sought to alter the course of the ageing process. Indeed, ageing has proved to be modifiable; by intervening in biological systems, such as nutrient sensing, cellular senescence, the systemic environment and the gut microbiome, phenotypes of ageing can be slowed sufficiently to mitigate age-related functional decline. These interventions can also delay the onset of many disabling, chronic diseases, including cancer, cardiovascular disease and neurodegeneration, in animal models. Here, we examine the most promising interventions to slow ageing and group them into two tiers based on the robustness of the preclinical, and some clinical, results, in which the top tier includes rapamycin, senolytics, metformin, acarbose, spermidine, NAD(+) enhancers and lithium. We then focus on the potential of the interventions and the feasibility of conducting clinical trials with these agents, with the overall aim of maintaining health for longer before the end of life. Several biological phenomena alter the ageing process. This Review discusses the most promising agents to slow ageing, separating them into two tiers based on their efficacy and evidence. The potential use of some interventions in clinical trials to expand overall healthspan as well as how those interventions could be assessed are also discussed.
C1 [Partridge, Linda] Max Planck Inst Biol Ageing, Dept Biol Mech Ageing, Cologne, Germany.
   [Partridge, Linda; Fuentealba, Matias] UCL, Inst Hlth Ageing, Dept Genet Evolut & Environm, London, England.
   [Kennedy, Brian K.] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Biochem, Singapore, Singapore.
   [Kennedy, Brian K.] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Physiol, Singapore, Singapore.
   [Kennedy, Brian K.] Natl Univ Singapore, Natl Univ Hlth Syst, Ctr Hlth Ageing, Singapore, Singapore.
   [Kennedy, Brian K.] ASTAR, Singapore Inst Clin Sci, Singapore, Singapore.
   [Kennedy, Brian K.] Buck Inst Res Aging, Novato, CA 94945 USA.
C3 Max Planck Society; University of London; University College London;
   National University of Singapore; National University of Singapore;
   National University of Singapore; Agency for Science Technology &
   Research (A*STAR); A*STAR - Singapore Institute for Clinical Sciences
   (SICS); Buck Institute for Research on Aging
RP Partridge, L (通讯作者)，Max Planck Inst Biol Ageing, Dept Biol Mech Ageing, Cologne, Germany.; Partridge, L (通讯作者)，UCL, Inst Hlth Ageing, Dept Genet Evolut & Environm, London, England.; Kennedy, BK (通讯作者)，Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Biochem, Singapore, Singapore.; Kennedy, BK (通讯作者)，Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Physiol, Singapore, Singapore.; Kennedy, BK (通讯作者)，Natl Univ Singapore, Natl Univ Hlth Syst, Ctr Hlth Ageing, Singapore, Singapore.; Kennedy, BK (通讯作者)，ASTAR, Singapore Inst Clin Sci, Singapore, Singapore.; Kennedy, BK (通讯作者)，Buck Inst Res Aging, Novato, CA 94945 USA.
EM linda.partridge@age.mpg.de; bkennedy@nus.edu.sg
RI Partridge, Linda/A-5501-2010
OI Partridge, Linda/0000-0001-9615-0094; Fuentealba,
   Matias/0000-0001-7353-4394
CR Adak T, 2018, REGUL TOXICOL PHARM, V92, P324, DOI 10.1016/j.yrtph.2017.12.023
   Admasu TD, 2018, DEV CELL, V47, P67, DOI 10.1016/j.devcel.2018.09.001
   Airhart SE, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0186459
   Alarcon-Aguilar FJ, 2008, EUR J PHARMACOL, V599, P152, DOI 10.1016/j.ejphar.2008.09.047
   Aliper A, 2016, AGING-US, V8, P2127, DOI 10.18632/aging.101047
   Alves A, 2019, NUTRIENTS, V11, DOI 10.3390/nu11061356
   An JY, 2017, GEROSCIENCE, V39, P457, DOI 10.1007/s11357-017-9994-6
   Anestakis D, 2015, INT J MOL SCI, V16, P1691, DOI 10.3390/ijms16011691
   Anisimov VN, 2013, CELL CYCLE, V12, P3483, DOI 10.4161/cc.26928
   Anisimov VN, 2011, CELL CYCLE, V10, P4230, DOI 10.4161/cc.10.24.18486
   [Anonymous], 2017, SCI TRANSL MED
   [Anonymous], 2016, STITCH CONS
   [Anonymous], 2015, DIGITAL AGING ATLAS
   [Anonymous], 2018, HUM AG GEN RES
   Apelo SIA, 2016, J GERONTOL A-BIOL, V71, P841, DOI 10.1093/gerona/glw090
   Araki K, 2009, NATURE, V460, P108, DOI 10.1038/nature08155
   Augustine JJ, 2007, DRUGS, V67, P369, DOI 10.2165/00003495-200767030-00004
   Baar MP, 2017, CELL, V169, P132, DOI 10.1016/j.cell.2017.02.031
   Baht GS, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms8131
   Bai X, 2015, PATHOBIOL AGING AGE, V5, DOI 10.3402/pba.v5.28743
   Baker DJ, 2016, NATURE, V530, P184, DOI 10.1038/nature16932
   Baker DJ, 2011, NATURE, V479, P232, DOI 10.1038/nature10600
   BALFOUR JA, 1993, DRUGS, V46, P1025, DOI 10.2165/00003495-199346060-00007
   Banerjee PS, 2016, MOL ASPECTS MED, V51, P1, DOI 10.1016/j.mam.2016.05.005
   Bannister CA, 2014, DIABETES OBES METAB, V16, P1165, DOI 10.1111/dom.12354
   Barardo DG, 2017, AGING-US, V9, P1721, DOI 10.18632/aging.101264
   Barzilai N, 2016, CELL METAB, V23, P1060, DOI 10.1016/j.cmet.2016.05.011
   Basisty N, 2020, PLOS BIOL, V18, DOI 10.1371/journal.pbio.3000599
   Beisswenger PJ, 1999, DIABETES, V48, P198, DOI 10.2337/diabetes.48.1.198
   Belenky P, 2007, CELL, V129, P473, DOI 10.1016/j.cell.2007.03.024
   Benedetti MG, 2008, EXP GERONTOL, V43, P882, DOI 10.1016/j.exger.2008.08.049
   Bertoldo MJ, 2020, CELL REP, V30, P1670, DOI 10.1016/j.celrep.2020.01.058
   Bhukel A, 2017, AUTOPHAGY, V13, P444, DOI 10.1080/15548627.2016.1265193
   Biagi E, 2016, CURR BIOL, V26, P1480, DOI 10.1016/j.cub.2016.04.016
   Bitto A, 2016, ELIFE, V5, DOI 10.7554/eLife.16351
   Bjedov I, 2010, CELL METAB, V11, P35, DOI 10.1016/j.cmet.2009.11.010
   Blankenburg H, 2018, BIOGERONTOLOGY, V19, P81, DOI 10.1007/s10522-017-9741-5
   Bos CL, 2006, ONCOGENE, V25, P6447, DOI 10.1038/sj.onc.1209658
   Bove J, 2011, NAT REV NEUROSCI, V12, P437, DOI 10.1038/nrn3068
   Bowker SL, 2010, DIABETOLOGIA, V53, P1631, DOI 10.1007/s00125-010-1750-8
   Bowman L, 2018, NEW ENGL J MED, V379, P1529, DOI 10.1056/NEJMoa1804988
   Brack AS, 2007, SCIENCE, V317, P807, DOI 10.1126/science.1144090
   Brewer Rachel A, 2016, Nutr Healthy Aging, V4, P31, DOI 10.3233/NHA-160007
   Brind J, 2011, FASEB J, V25
   Broad Institute, 2018, CONN MAP CMAP
   Brown AS, 2017, SCI DATA, V4, DOI 10.1038/sdata.2017.29
   Brunt KR, 2012, AM J PATHOL, V181, P2067, DOI 10.1016/j.ajpath.2012.08.021
   Cabreiro F, 2013, CELL, V153, P228, DOI 10.1016/j.cell.2013.02.035
   Cacicedo JM, 2004, BIOCHEM BIOPH RES CO, V324, P1204, DOI 10.1016/j.bbrc.2004.09.177
   Calvert S, 2016, AGING CELL, V15, P256, DOI 10.1111/acel.12432
   Cameron AR, 2016, CIRC RES, V119, P652, DOI 10.1161/CIRCRESAHA.116.308445
   Campbell JM, 2017, AGEING RES REV, V40, P31, DOI 10.1016/j.arr.2017.08.003
   Campisi J, 2013, ANNU REV PHYSIOL, V75, P685, DOI 10.1146/annurev-physiol-030212-183653
   Cao Y, 2016, JAMA ONCOL, V2, P762, DOI 10.1001/jamaoncol.2015.6396
   Castellano JM, 2017, NATURE, V544, P488, DOI 10.1038/nature22067
   Castillo-Quan JI, 2019, P NATL ACAD SCI USA, V116, P20817, DOI 10.1073/pnas.1913212116
   Castillo-Quan JI, 2016, CELL REP, V15, P638, DOI 10.1016/j.celrep.2016.03.041
   Cavalcante MB, 2020, AGING-US, V12, P2711, DOI 10.18632/aging.102772
   Chen C, 2009, SCI SIGNAL, V2, DOI 10.1126/scisignal.2000559
   Chen D, 2013, CELL REP, V5, P1600, DOI 10.1016/j.celrep.2013.11.018
   Chen J, 2017, ELIFE, V6, DOI 10.7554/eLife.31268
   Chen WY, 2015, CELL RES, V25, P574, DOI 10.1038/cr.2015.36
   Childs BG, 2017, NAT REV DRUG DISCOV, V16, P718, DOI 10.1038/nrd.2017.116
   Childs BG, 2016, SCIENCE, V354, P472, DOI 10.1126/science.aaf6659
   Ching TT, 2011, AGING CELL, V10, P506, DOI 10.1111/j.1474-9726.2011.00688.x
   Chiu CT, 2010, PHARMACOL THERAPEUT, V128, P281, DOI 10.1016/j.pharmthera.2010.07.006
   Claesen M, 2016, J CLIN ENDOCR METAB, V101, P461, DOI 10.1210/jc.2015-3184
   Clark RI, 2015, CELL REP, V12, P1656, DOI 10.1016/j.celrep.2015.08.004
   Collado M, 2010, NAT REV CANCER, V10, P51, DOI 10.1038/nrc2772
   Colman RJ, 2009, SCIENCE, V325, P201, DOI 10.1126/science.1173635
   Conboy IM, 2005, NATURE, V433, P760, DOI 10.1038/nature03260
   Conboy MJ, 2013, AGING CELL, V12, P525, DOI 10.1111/acel.12065
   Conze DB, 2016, HUM EXP TOXICOL, V35, P1149, DOI 10.1177/0960327115626254
   Coppe JP, 2008, PLOS BIOL, V6, P2853, DOI 10.1371/journal.pbio.0060301
   Cordey M, 2005, NEUROBIOL DIS, V19, P331, DOI 10.1016/j.nbd.2005.01.011
   Craig T, 2015, NUCLEIC ACIDS RES, V43, pD873, DOI 10.1093/nar/gku843
   Currie CJ, 2009, DIABETOLOGIA, V52, P1766, DOI 10.1007/s00125-009-1440-6
   Cuyas E, 2018, AGING CELL, V17, DOI 10.1111/acel.12772
   Cuzick J, 2017, LANCET ONCOL, V18, pE472, DOI 10.1016/S1470-2045(17)30536-3
   Dai DF, 2014, AGING CELL, V13, P529, DOI 10.1111/acel.12203
   Dai H, 2018, PHARMACOL THERAPEUT, V188, P140, DOI 10.1016/j.pharmthera.2018.03.004
   Dai LX, 2011, BMC BIOCHEM, V12, DOI 10.1186/1471-2091-12-18
   Dakik Pamela, 2019, Oncotarget, V10, P313, DOI 10.18632/oncotarget.26553
   Dalirfardouei R, 2016, LIFE SCI, V152, P21, DOI 10.1016/j.lfs.2016.03.028
   Danilov A, 2015, ONCOTARGET, V6, P19428, DOI 10.18632/oncotarget.5118
   de Cabo R, 2014, CELL, V157, P1515, DOI 10.1016/j.cell.2014.05.031
   De Cecco M, 2019, NATURE, V566, P73, DOI 10.1038/s41586-018-0784-9
   De Haes W, 2014, P NATL ACAD SCI USA, V111, pE2501, DOI 10.1073/pnas.1321776111
   de Magalhaes JP, 2017, TRENDS BIOTECHNOL, V35, P1062, DOI 10.1016/j.tibtech.2017.07.004
   de Oliveira MA, 2011, ORAL ONCOL, V47, P998, DOI 10.1016/j.oraloncology.2011.08.009
   de Picciotto NE, 2016, AGING CELL, V15, P522, DOI 10.1111/acel.12461
   Delgoffe GM, 2009, IMMUNITY, V30, P832, DOI 10.1016/j.immuni.2009.04.014
   Dellinger RW, 2017, NPJ AGING MECH DIS, V3, DOI 10.1038/s41514-017-0016-9
   Demaria M, 2017, CANCER DISCOV, V7, P165, DOI 10.1158/2159-8290.CD-16-0241
   Demaria M, 2014, DEV CELL, V31, P722, DOI 10.1016/j.devcel.2014.11.012
   Dhahbi JM, 2005, PHYSIOL GENOMICS, V23, P343, DOI 10.1152/physiolgenomics.00069.2005
   Dollerup OL, 2018, AM J CLIN NUTR, V108, P343, DOI 10.1093/ajcn/nqy132
   Donertas HM, 2019, TRENDS ENDOCRIN MET, V30, P118, DOI 10.1016/j.tem.2018.11.005
   Donertas HM, 2018, AGING CELL, V17, DOI 10.1111/acel.12819
   Dou XW, 2017, AGING CELL, V16, P825, DOI 10.1111/acel.12617
   Edwards C, 2015, BMC GENET, V16, DOI 10.1186/s12863-015-0167-2
   Egerman MA, 2015, CELL METAB, V22, P164, DOI 10.1016/j.cmet.2015.05.010
   Eisenberg T, 2016, NAT MED, V22, P1428, DOI 10.1038/nm.4222
   Eisenberg T, 2009, NAT CELL BIOL, V11, P1305, DOI 10.1038/ncb1975
   Elhassan YS, 2019, CELL REP, V28, P1717, DOI 10.1016/j.celrep.2019.07.043
   Evangelista L, 2019, LANCET, V393, P1493, DOI 10.1016/S0140-6736(19)30800-1
   Fabbiano S, 2018, CELL METAB, V28, P907, DOI 10.1016/j.cmet.2018.08.005
   Fan XL, 2015, ONCOTARGET, V6, P35274, DOI 10.18632/oncotarget.5895
   Farina F, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-04256-w
   Farr JN, 2017, NAT MED, V23, P1072, DOI 10.1038/nm.4385
   Figueira I, 2016, MECH AGEING DEV, V160, P69, DOI 10.1016/j.mad.2016.09.009
   Flynn JM, 2013, AGING CELL, V12, P851, DOI 10.1111/acel.12109
   Fontana L, 2015, CELL, V161, P106, DOI 10.1016/j.cell.2015.02.020
   Fontana L, 2010, SCIENCE, V328, P321, DOI 10.1126/science.1172539
   Forlenza OV, 2014, ACS CHEM NEUROSCI, V5, P443, DOI 10.1021/cn5000309
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Franceschi C, 2018, NAT REV ENDOCRINOL, V14, P576, DOI 10.1038/s41574-018-0059-4
   Franciosi M, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0071583
   Fransquet PD, 2019, CLIN EPIGENETICS, V11, DOI 10.1186/s13148-019-0656-7
   Fuentealba M, 2019, PLOS COMPUT BIOL, V15, DOI 10.1371/journal.pcbi.1006639
   Fuhrmann-Stroissnigg H, 2018, CELL CYCLE, V17, P1048, DOI 10.1080/15384101.2018.1475828
   Fuhrmann-Stroissnigg H, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-00314-z
   Gandini S, 2014, CANCER PREV RES, V7, P867, DOI 10.1158/1940-6207.CAPR-13-0424
   Garcia-Prat L, 2016, AUTOPHAGY, V12, P612, DOI 10.1080/15548627.2016.1143211
   Garratt M, 2019, AGING CELL, V18, DOI 10.1111/acel.12920
   Garratt M, 2017, AGING CELL, V16, P1256, DOI 10.1111/acel.12656
   Gasior SL, 2006, J MOL BIOL, V357, P1383, DOI 10.1016/j.jmb.2006.01.089
   Gelinas S, 2004, NEUROTOX RES, V6, P141, DOI 10.1007/BF03033216
   Gilbert N, 2002, CELL, V110, P315, DOI 10.1016/S0092-8674(02)00828-0
   Goldman D., 2015, COLD SPRING HARB PER, V6
   Gontier G, 2018, CELL REP, V22, P1974, DOI 10.1016/j.celrep.2018.02.001
   Goodwin K, 2006, VACCINE, V24, P1159, DOI 10.1016/j.vaccine.2005.08.105
   Grabiner BC, 2014, CANCER DISCOV, V4, P554, DOI 10.1158/2159-8290.CD-13-0929
   Green PS, 1997, J NEUROSCI, V17, P511
   Green PS, 1996, NEUROSCI LETT, V218, P165, DOI 10.1016/S0304-3940(96)13148-7
   Guerrero A, 2019, NAT METAB, V1, P1074, DOI 10.1038/s42255-019-0122-z
   Guirguis-Blake JM, 2015, ASPIRIN PRIMARY PREV
   Ha CW, 2011, NUCLEIC ACIDS RES, V39, P1336, DOI 10.1093/nar/gkq895
   Haller S, 2017, CELL STEM CELL, V21, P806, DOI 10.1016/j.stem.2017.11.008
   Halloran J, 2012, NEUROSCIENCE, V223, P102, DOI 10.1016/j.neuroscience.2012.06.054
   Hancks DC, 2012, CURR OPIN GENET DEV, V22, P191, DOI 10.1016/j.gde.2012.02.006
   HARA T, 1992, EMBO J, V11, P1875, DOI 10.1002/j.1460-2075.1992.tb05239.x
   Hardy J, 2017, BRAIN, V140, P853, DOI 10.1093/brain/awx059
   Harrison DE, 2019, AGING CELL, V18, DOI 10.1111/acel.12898
   Harrison DE, 2014, AGING CELL, V13, P273, DOI 10.1111/acel.12170
   Harrison DE, 2009, NATURE, V460, P392, DOI 10.1038/nature08221
   Hattori Y, 2006, HYPERTENSION, V47, P1183, DOI 10.1161/01.HYP.0000221429.94591.72
   Hawley SA, 2012, SCIENCE, V336, P918, DOI 10.1126/science.1215327
   Haxhinasto S, 2008, J EXP MED, V205, P565, DOI 10.1084/jem.20071477
   Hayden EC, 2015, NATURE, V522, P265, DOI 10.1038/522265a
   He C, 2014, PLOS GENET, V10, DOI 10.1371/journal.pgen.1004860
   He L, 2009, CELL, V137, P635, DOI 10.1016/j.cell.2009.03.016
   Herranz N, 2018, J CLIN INVEST, V128, P1238, DOI 10.1172/JCI95148
   Hikosaka K, 2021, NUTR NEUROSCI, V24, P371, DOI 10.1080/1028415X.2019.1637504
   Himmelstein DS, 2017, ELIFE, V6, DOI 10.7554/eLife.26726
   Hinken AC, 2016, AGING CELL, V15, P582, DOI 10.1111/acel.12475
   Hoose SA, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0036503
   Horiuchi T, 2017, J BIOL CHEM, V292, P8436, DOI 10.1074/jbc.M116.769380
   Horowitz Alana M, 2017, F1000Res, V6, P1291, DOI 10.12688/f1000research.11437.1
   Horvath S, 2018, NAT REV GENET, V19, P371, DOI 10.1038/s41576-018-0004-3
   Hotamisligil GS, 2017, NATURE, V542, P177, DOI 10.1038/nature21363
   Hou L, 2016, CELL METAB, V23, P529, DOI 10.1016/j.cmet.2016.02.002
   Hsieh MC, 2012, EXP DIABETES RES, DOI 10.1155/2012/413782
   Huang Q, 2018, J GERONTOL A-BIOL, V73, P421, DOI 10.1093/gerona/glx183
   Hurst JR, 2018, LANCET GLOB HEALTH, V6, pE1270, DOI 10.1016/S2214-109X(18)30391-7
   Hwang AB, 2014, P NATL ACAD SCI USA, V111, pE4458, DOI 10.1073/pnas.1411199111
   Ibanez L, 2006, HUM REPROD, V21, P451, DOI 10.1093/humrep/dei329
   IMS Institute for Healthcare Informatics, 2012, NAT PRESCR AUD DEC 2
   Iskow RC, 2010, CELL, V141, P1253, DOI 10.1016/j.cell.2010.05.020
   Janssens GE, 2019, CELL REP, V27, P467, DOI 10.1016/j.celrep.2019.03.044
   Jeon OH, 2018, J CLIN INVEST, V128, P1229, DOI 10.1172/JCI95147
   Jeon OH, 2017, NAT MED, V23, P775, DOI 10.1038/nm.4324
   Jia K, 2004, DEVELOPMENT, V131, P3897, DOI 10.1242/dev.01255
   Johnson SC, 2015, FRONT GENET, V6, DOI 10.3389/fgene.2015.00247
   Jones RB, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0001547
   Justice JN, 2019, EBIOMEDICINE, V40, P554, DOI 10.1016/j.ebiom.2018.12.052
   Justice JN, 2018, CARDIOVASC ENDOCR ME, V7, P80, DOI 10.1097/XCE.0000000000000159
   Kaeberlein M, 2005, SCIENCE, V310, P1193, DOI 10.1126/science.1115535
   Kapahi P, 2004, CURR BIOL, V14, P885, DOI 10.1016/j.cub.2004.03.059
   Kashyap D, 2019, BIOMOLECULES, V9, DOI 10.3390/biom9050174
   Katsimpardi L, 2014, SCIENCE, V344, P630, DOI 10.1126/science.1251141
   Kennedy BK, 2016, ANN AM THORAC SOC, V13, pS398, DOI 10.1513/AnnalsATS.201609-680AW
   Kennedy BK, 2016, CELL METAB, V23, P990, DOI 10.1016/j.cmet.2016.05.009
   Kenyon CJ, 2010, NATURE, V464, P504, DOI 10.1038/nature08980
   Khosla S, 2018, J CLIN ENDOCR METAB, V103, P1282, DOI 10.1210/jc.2017-02694
   Kiechl S, 2018, AM J CLIN NUTR, V108, P371, DOI 10.1093/ajcn/nqy102
   Kim S, 2016, NUCLEIC ACIDS RES, V44, pD1202, DOI 10.1093/nar/gkv951
   Kirkland JL, 2017, EBIOMEDICINE, V21, P21, DOI 10.1016/j.ebiom.2017.04.013
   Kirpichnikov D, 2002, ANN INTERN MED, V137, P25, DOI 10.7326/0003-4819-137-1-200207020-00009
   Kitada M, 2019, EBIOMEDICINE, V43, P632, DOI 10.1016/j.ebiom.2019.04.005
   Konopka AR, 2019, AGING CELL, V18, DOI 10.1111/acel.12880
   Kooy A, 2009, ARCH INTERN MED, V169, P616, DOI 10.1001/archinternmed.2009.20
   Kulkarni AS, 2018, AGING CELL, V17, DOI 10.1111/acel.12723
   Kumar Surinder, 2016, F1000Res, V5, DOI 10.12688/f1000research.7821.1
   Lamb J, 2006, SCIENCE, V313, P1929, DOI 10.1126/science.1132939
   Lamming DW, 2012, SCIENCE, V335, P1638, DOI 10.1126/science.1215135
   Lander ES, 2001, NATURE, V409, P860, DOI 10.1038/35057062
   Langille MG, 2014, MICROBIOME, V2, DOI 10.1186/s40168-014-0050-9
   Laplante M, 2012, CELL, V149, P274, DOI 10.1016/j.cell.2012.03.017
   Le S, 2019, CLIN DRUG INVEST, V39, P757, DOI 10.1007/s40261-019-00799-0
   Lelegren M, 2016, PATHOBIOL AGING AGE, V6, DOI 10.3402/pba.v6.31793
   Lesniewski LA, 2017, AGING CELL, V16, P17, DOI 10.1111/acel.12524
   Li J, 2014, CELL METAB, V19, P373, DOI 10.1016/j.cmet.2014.01.001
   Libby G, 2009, DIABETES CARE, V32, P1620, DOI 10.2337/dc08-2175
   Lin AL, 2017, J CEREBR BLOOD F MET, V37, P217, DOI 10.1177/0271678X15621575
   Liu H, 2016, BMC SYST BIOL, V10, DOI 10.1186/s12918-016-0362-4
   Liu YJ, 2019, PLOS GENET, V15, DOI 10.1371/journal.pgen.1007633
   Loffredo FS, 2013, CELL, V153, P828, DOI 10.1016/j.cell.2013.04.015
   Longo VD, 2015, AGING CELL, V14, P497, DOI 10.1111/acel.12338
   Lopez-Otin C, 2013, CELL, V153, P1194, DOI 10.1016/j.cell.2013.05.039
   Madeo F, 2018, SCIENCE, V359, P410, DOI 10.1126/science.aan2788
   Maglione M, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-56133-3
   Majumder S, 2012, AGING CELL, V11, P326, DOI 10.1111/j.1474-9726.2011.00791.x
   Mallikarjun V, 2016, EBIOMEDICINE, V14, P24, DOI 10.1016/j.ebiom.2016.11.020
   Mannick JB, 2018, SCI TRANSL MED, V10, DOI 10.1126/scitranslmed.aaq1564
   Mannick JB, 2014, SCI TRANSL MED, V6, DOI 10.1126/scitranslmed.3009892
   Margolis AM, 2014, J MED TOXICOL, V10, P26, DOI 10.1007/s13181-013-0325-8
   Marino G, 2014, MOL CELL, V53, P710, DOI 10.1016/j.molcel.2014.01.016
   Marshall SM, 2017, DIABETOLOGIA, V60, P1561, DOI 10.1007/s00125-017-4343-y
   Martin-Montalvo A, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms3192
   Martinsson L, 2013, TRANSL PSYCHIAT, V3, DOI 10.1038/tp.2013.37
   Massudi H, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0042357
   Mattison JA, 2017, NAT COMMUN, V8, DOI 10.1038/ncomms14063
   Mattison JA, 2012, NATURE, V489, P318, DOI 10.1038/nature11432
   McColl G, 2008, J BIOL CHEM, V283, P350, DOI 10.1074/jbc.M705028200
   McNeil JJ, 2018, NEW ENGL J MED, V379, P1519, DOI 10.1056/NEJMoa1803955
   McNeil JJ, 2018, NEW ENGL J MED, V379, P1499, DOI 10.1056/NEJMoa1800722
   McNeil JJ, 2018, NEW ENGL J MED, V379, P1509, DOI 10.1056/NEJMoa1805819
   Menzies FM, 2010, AUTOPHAGY, V6, P286, DOI 10.4161/auto.6.2.11078
   Middeldorp J, 2016, JAMA NEUROL, V73, P1325, DOI 10.1001/jamaneurol.2016.3185
   Miller RA, 2019, AGING CELL, V18, DOI 10.1111/acel.12953
   Miller RA, 2011, J GERONTOL A-BIOL, V66, P191, DOI 10.1093/gerona/glq178
   Mills KF, 2016, CELL METAB, V24, P795, DOI 10.1016/j.cmet.2016.09.013
   Moiseeva O, 2013, AGING CELL, V12, P489, DOI 10.1111/acel.12075
   Moskalev A, 2017, AGING DIS, V8, P354, DOI 10.14336/AD.2016.1022
   Moskalev A, 2016, AGING CELL, V15, P407, DOI 10.1111/acel.12463
   Moskalev A, 2015, AGING-US, V7, P616, DOI 10.18632/aging.100799
   Mostoslavsky R, 2006, CELL, V124, P315, DOI 10.1016/J.CEL.2005.11.044
   Mouchiroud L, 2013, CELL, V154, P430, DOI 10.1016/j.cell.2013.06.016
   Munoz-Espin D, 2014, NAT REV MOL CELL BIO, V15, P482, DOI 10.1038/nrm3823
   Munoz-Espin D, 2013, CELL, V155, P1104, DOI 10.1016/j.cell.2013.10.019
   Murphy Sherry L, 2013, Natl Vital Stat Rep, V61, P1
   Murray-Stewart TR, 2016, BIOCHEM J, V473, P2937, DOI 10.1042/BCJ20160383
   Nathan DM, 2006, DIABETES CARE, V29, P1963, DOI 10.2337/dc06-9912
   National Institute on Aging, 2019, INT TEST PROGR ITP
   Neff F, 2013, J CLIN INVEST, V123, P3272, DOI 10.1172/JCI67674
   Niccoli T, 2017, HUM MOL GENET, V26, pR105, DOI 10.1093/hmg/ddx247
   Niccoli T, 2012, CURR BIOL, V22, pR741, DOI 10.1016/j.cub.2012.07.024
   Noro T, 2015, CELL DEATH DIS, V6, DOI 10.1038/cddis.2015.93
   O'Toole PW, 2015, SCIENCE, V350, P1214, DOI 10.1126/science.aac8469
   Ogrodnik M, 2017, NAT COMMUN, V8, DOI 10.1038/ncomms15691
   Ohgami H, 2009, BRIT J PSYCHIAT, V194, P464, DOI 10.1192/bjp.bp.108.055798
   Olshansky SJ, 2016, CSH PERSPECT MED, V6, DOI 10.1101/cshperspect.a025940
   Onken B, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0008758
   Ozcelik S, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0062459
   Palmer AK, 2019, AGING CELL, V18, DOI 10.1111/acel.12950
   Palmer SC, 2016, JAMA-J AM MED ASSOC, V316, P313, DOI 10.1001/jama.2016.9400
   Parkhitko AA, 2019, AGING CELL, V18, DOI 10.1111/acel.13034
   Partridge L, 2018, NATURE, V561, P45, DOI 10.1038/s41586-018-0457-8
   Pegg AE, 2016, J BIOL CHEM, V291, P14904, DOI 10.1074/jbc.R116.731661
   Petrascheck M, 2007, NATURE, V450, P553, DOI 10.1038/nature05991
   Pietrocola F, 2015, CELL DEATH DIFFER, V22, P509, DOI 10.1038/cdd.2014.215
   Piper MDW, 2017, CELL METAB, V25, P1206, DOI 10.1016/j.cmet.2017.04.020
   Pollizzi KN, 2016, NAT IMMUNOL, V17, P704, DOI 10.1038/ni.3438
   Pollizzi KN, 2015, TRENDS IMMUNOL, V36, P13, DOI 10.1016/j.it.2014.11.005
   Poly TN, 2019, EUR J CLIN PHARMACOL, V75, P99, DOI 10.1007/s00228-018-2561-y
   Popovich IG, 2014, CANCER BIOL THER, V15, P586, DOI 10.4161/cbt.28164
   Powell JD, 2012, ANNU REV IMMUNOL, V30, P39, DOI 10.1146/annurev-immunol-020711-075024
   Powers RW, 2006, GENE DEV, V20, P174, DOI 10.1101/gad.1381406
   Qiu H, 2013, DIABETES OBES METAB, V15, P349, DOI 10.1111/dom.12036
   Quiroz JA, 2010, NEUROPSYCHOBIOLOGY, V62, P50, DOI 10.1159/000314310
   Rajman L, 2018, CELL METAB, V27, P529, DOI 10.1016/j.cmet.2018.02.011
   Ramsey KM, 2008, AGING CELL, V7, P78, DOI 10.1111/j.1474-9726.2007.00355.x
   Ravikumar B, 2004, NAT GENET, V36, P585, DOI 10.1038/ng1362
   Reifsnyder PC, 2016, AGING-US, V8, P3120, DOI 10.18632/aging.101117
   Reilly MT, 2013, J NEUROSCI, V33, P17577, DOI 10.1523/JNEUROSCI.3369-13.2013
   Ren TT, 2006, J MOL ENDOCRINOL, V37, P175, DOI 10.1677/jme.1.02061
   Rena G, 2017, DIABETOLOGIA, V60, P1577, DOI 10.1007/s00125-017-4342-z
   Renna M, 2010, J BIOL CHEM, V285, P11061, DOI 10.1074/jbc.R109.072181
   Richardson A, 2015, EXP GERONTOL, V68, P51, DOI 10.1016/j.exger.2014.12.002
   Roberts MN, 2017, CELL METAB, V26, P539, DOI 10.1016/j.cmet.2017.08.005
   Robida-Stubbs S, 2012, CELL METAB, V15, P713, DOI 10.1016/j.cmet.2012.04.007
   ROME LH, 1975, P NATL ACAD SCI USA, V72, P4863, DOI 10.1073/pnas.72.12.4863
   Roos CM, 2016, AGING CELL, V15, P973, DOI 10.1111/acel.12458
   Rosak C, 2012, DIABET METAB SYND OB, V5, P357, DOI 10.2147/DMSO.S28340
   Ross C, 2015, AGING-US, V7, P964, DOI 10.18632/aging.100843
   Rothwell PM, 2012, LANCET, V379, P1591, DOI 10.1016/S0140-6736(12)60209-8
   Rothwell PM, 2010, LANCET, V376, P1741, DOI 10.1016/S0140-6736(10)61543-7
   RSC ChemSpider, 2015, ROYAL SOC CHEM
   Ruckh JM, 2012, CELL STEM CELL, V10, P96, DOI 10.1016/j.stem.2011.11.019
   Ruiter R, 2012, DIABETES CARE, V35, P119, DOI 10.2337/dc11-0857
   Sacitharan PK, 2019, EXP MOL MED, V51, DOI 10.1038/s12276-019-0225-3
   Sadagurski M, 2017, AGING CELL, V16, P652, DOI 10.1111/acel.12590
   Sagi D, 2012, PLOS GENET, V8, DOI 10.1371/journal.pgen.1002780
   Salpeter SJ, 2013, DIABETES, V62, P2843, DOI 10.2337/db13-0160
   Sarbassov DD, 2006, MOL CELL, V22, P159, DOI 10.1016/j.molcel.2006.03.029
   Sarkar S, 2005, J CELL BIOL, V170, P1101, DOI 10.1083/jcb.200504035
   Sarkar S, 2008, HUM MOL GENET, V17, P170, DOI 10.1093/hmg/ddm294
   Sarnoski EA, 2017, CELL REP, V21, P2639, DOI 10.1016/j.celrep.2017.11.002
   Saxton RA, 2017, CELL, V168, P960, DOI [10.1016/j.cell.2017.02.004, 10.1016/j.cell.2017.03.035]
   SCALABRINO G, 1984, MECH AGEING DEV, V26, P149, DOI 10.1016/0047-6374(84)90090-3
   Schafer MJ, 2017, NAT COMMUN, V8, DOI 10.1038/ncomms14532
   Schrauzer GN, 2010, BRIT J PSYCHIAT, V196, P159, DOI 10.1192/bjp.196.2.159a
   Schreiber KH, 2015, AGING CELL, V14, P265, DOI 10.1111/acel.12313
   Schubert D, 2018, TRENDS PHARMACOL SCI, V39, P1004, DOI 10.1016/j.tips.2018.09.008
   Sciarretta S, 2018, CIRC RES, V122, P489, DOI 10.1161/CIRCRESAHA.117.311147
   Selman C, 2009, SCIENCE, V326, P140, DOI 10.1126/science.1177221
   Sha SJ, 2019, JAMA NEUROL, V76, P35, DOI 10.1001/jamaneurol.2018.3288
   Sharma M, 2016, BMJ OPEN, V6, DOI 10.1136/bmjopen-2015-010210
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Simon M, 2019, CELL METAB, V29, P871, DOI 10.1016/j.cmet.2019.02.014
   Simpson SJ, 2017, AGEING RES REV, V39, P78, DOI 10.1016/j.arr.2017.03.001
   Sinha M, 2014, SCIENCE, V344, P649, DOI 10.1126/science.1251152
   Slack C, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0047699
   Smith BJ, 2019, BMC MICROBIOL, V19, DOI 10.1186/s12866-019-1494-7
   Smith LK, 2015, NAT MED, V21, P932, DOI 10.1038/nm.3898
   Snell TW, 2018, BIOGERONTOLOGY, V19, P145, DOI 10.1007/s10522-018-9745-9
   Sofola-Adesakin O, 2014, FRONT AGING NEUROSCI, V6, DOI 10.3389/fnagi.2014.00190
   Song CC, 2017, EXP GERONTOL, V95, P54, DOI 10.1016/j.exger.2017.04.010
   Spilman P, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009979
   Stein BD, 2019, CELL REP, V29, P3331, DOI 10.1016/j.celrep.2019.10.117
   Stekovic S, 2019, CELL METAB, V30, P462, DOI 10.1016/j.cmet.2019.07.016
   Steyn FJ, 2018, AGING CELL, V17, DOI 10.1111/acel.12703
   Stout MB, 2017, J GERONTOL A-BIOL, V72, P3, DOI 10.1093/gerona/glv309
   Strong R, 2008, AGING CELL, V7, P641, DOI 10.1111/j.1474-9726.2008.00414.x
   Strong R, 2016, AGING CELL, V15, P872, DOI 10.1111/acel.12496
   Subramanian A, 2017, CELL, V171, P1437, DOI 10.1016/j.cell.2017.10.049
   Sun DN, 2017, CANCER LETT, V406, P105, DOI 10.1016/j.canlet.2017.06.029
   Sung JY, 2018, EXP GERONTOL, V109, P51, DOI 10.1016/j.exger.2017.08.001
   Tacutu R, 2018, NUCLEIC ACIDS RES, V46, pD1083, DOI 10.1093/nar/gkx1042
   Tain LS, 2020, AGING CELL, V19, DOI 10.1111/acel.13043
   Tam ZY, 2014, J GERONTOL A-BIOL, V69, P810, DOI 10.1093/gerona/glt210
   Tarakad A, 2017, SEMIN NEUROL, V37, P118, DOI 10.1055/s-0037-1601888
   Tardif S, 2015, J GERONTOL A-BIOL, V70, P577, DOI 10.1093/gerona/glu101
   Trammell SAJ, 2016, NAT COMMUN, V7, DOI 10.1038/ncomms12948
   Trendelenburg AU, 2019, MECH AGEING DEV, V180, P11, DOI 10.1016/j.mad.2019.03.002
   Triana-Martinez F, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-12888-x
   Turner RC, 1998, LANCET, V352, P854, DOI 10.1016/s0140-6736(98)07037-8
   Urfer SR, 2017, GEROSCIENCE, V39, P117, DOI 10.1007/s11357-017-9972-z
   Vaiserman AM, 2016, AGEING RES REV, V31, P9, DOI 10.1016/j.arr.2016.08.004
   van Deursen JM, 2014, NATURE, V509, P439, DOI 10.1038/nature13193
   Van Meter M, 2014, NAT COMMUN, V5, DOI 10.1038/ncomms6011
   Vane J, 2000, THORAX, V55, pS3, DOI 10.1136/thorax.55.suppl_2.S3
   Vatolin S, 2019, NPJ AGING MECH DIS, V5, DOI 10.1038/s41514-018-0032-4
   Vellai T, 2003, NATURE, V426, P620, DOI 10.1038/426620a
   Verbist KC, 2016, NATURE, V532, P389, DOI 10.1038/nature17442
   Villeda SA, 2014, NAT MED, V20, P659, DOI 10.1038/nm.3569
   Villeda SA, 2011, NATURE, V477, P90, DOI 10.1038/nature10357
   Vlad SC, 2008, NEUROLOGY, V70, P1672, DOI 10.1212/01.wnl.0000311269.57716.63
   Walters HE, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19082325
   Wan QL, 2013, EXP GERONTOL, V48, P499, DOI 10.1016/j.exger.2013.02.020
   Wang CP, 2017, J DIABETES COMPLICAT, V31, P679, DOI [10.1016/jjdiacomp.2017.01.013, 10.1016/j.jdiacomp.2017.01.013]
   Wang JY, 2020, AGING-US, V12, P650, DOI 10.18632/aging.102647
   Wang R, 2017, EXP GERONTOL, V94, P89, DOI 10.1016/j.exger.2017.01.026
   Wang R, 2017, AGING CELL, V16, P564, DOI 10.1111/acel.12587
   Wang TN, 2017, GENOME BIOL, V18, DOI 10.1186/s13059-017-1186-2
   Wang WW, 2013, AMINO ACIDS, V45, P463, DOI 10.1007/s00726-013-1493-1
   Waterston RH, 2002, NATURE, V420, P520, DOI 10.1038/nature01262
   Weimer S, 2014, NAT COMMUN, V5, DOI 10.1038/ncomms4563
   Wilkinson JE, 2012, AGING CELL, V11, P675, DOI 10.1111/j.1474-9726.2012.00832.x
   Witters LA, 2001, J CLIN INVEST, V108, P1105, DOI 10.1172/JCI14178
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Wu JJ, 2013, CELL REP, V4, P913, DOI 10.1016/j.celrep.2013.07.030
   Wyss-Coray T, 2016, NATURE, V539, P180, DOI 10.1038/nature20411
   Xu JN, 2016, J CLIN INVEST, V126, P3526, DOI 10.1172/JCI86120
   Xu M, 2018, NAT MED, V24, P1246, DOI 10.1038/s41591-018-0092-9
   Yamamoto M, 2006, METABOLISM, V55, P533, DOI 10.1016/j.metabol.2005.11.007
   Yanai H, 2018, AGEING RES REV, V41, P18, DOI 10.1016/j.arr.2017.10.004
   Yang JL, 2020, GEROSCIENCE, V42, P353, DOI 10.1007/s11357-019-00106-x
   Yang W, 2010, PLOS BIOL, V8, DOI 10.1371/journal.pbio.1000556
   Ye XL, 2014, AGING CELL, V13, P206, DOI 10.1111/acel.12163
   Yilmaz OH, 2012, NATURE, V486, P490, DOI 10.1038/nature11163
   Yin MJ, 1998, NATURE, V396, P77, DOI 10.1038/23948
   Yoshino J, 2018, CELL METAB, V27, P513, DOI 10.1016/j.cmet.2017.11.002
   Yousef H, 2019, NAT MED, V25, P988, DOI 10.1038/s41591-019-0440-4
   Yousefzadeh MJ, 2018, EBIOMEDICINE, V36, P18, DOI 10.1016/j.ebiom.2018.09.015
   Yue F, 2017, CANCER RES, V77, P2938, DOI 10.1158/0008-5472.CAN-16-3462
   Zarse K, 2011, EUR J NUTR, V50, P387, DOI 10.1007/s00394-011-0171-x
   Zhang HL, 2019, MOL CELL, V76, P110, DOI 10.1016/j.molcel.2019.08.005
   Zhang HB, 2016, SCIENCE, V352, P1436, DOI 10.1126/science.aaf2693
   Zhang X, 2015, TRANSL PSYCHIAT, V5, DOI 10.1038/tp.2015.31
   Zhang X, 2011, J ALZHEIMERS DIS, V24, P739, DOI 10.3233/JAD-2011-101875
   Zheng Y, 2007, J IMMUNOL, V178, P2163, DOI 10.4049/jimmunol.178.4.2163
   Zhong Z, 2003, CURR OPIN CLIN NUTR, V6, P229, DOI 10.1097/00075197-200303000-00013
   Zhou ZY, 2016, ACTA PHARMACOL SIN, V37, P1063, DOI 10.1038/aps.2016.21
   Zhu XH, 2015, P NATL ACAD SCI USA, V112, P2876, DOI 10.1073/pnas.1417921112
   Zhu Y, 2015, AGING CELL, V14, P644, DOI 10.1111/acel.12344
   Zimmermann A, 2018, FEMS YEAST RES, V18, DOI 10.1093/femsyr/foy020
NR 388
TC 157
Z9 161
U1 41
U2 199
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 1474-1776
EI 1474-1784
J9 NAT REV DRUG DISCOV
JI Nat. Rev. Drug Discov.
PD AUG
PY 2020
VL 19
IS 8
BP 513
EP 532
DI 10.1038/s41573-020-0067-7
PG 20
WC Biotechnology & Applied Microbiology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Biotechnology & Applied Microbiology; Pharmacology & Pharmacy
GA PG0FY
UT WOS:000599421200013
PM 32467649
OA Green Submitted
HC Y
HP N
DA 2023-06-08
ER

PT J
AU Verges, B
AF Verges, Bruno
TI Intestinal lipid absorption and transport in type 2 diabetes
SO DIABETOLOGIA
LA English
DT Review
DE Chylomicron; Diabetes; Glucagon-like peptide-1; Insulin; Intestine;
   Lipids; Postprandial hyperlipidaemia; Review
ID GLUCAGON-LIKE PEPTIDE-1; GASTRIC-INHIBITORY POLYPEPTIDE;
   TRIGLYCERIDE-RICH LIPOPROTEINS; PICK C1-LIKE 1; INSULIN-RESISTANCE;
   CHYLOMICRON PRODUCTION; POSTPRANDIAL LIPEMIA; APOLIPOPROTEIN B-48;
   TRANSFER PROTEIN; HIGH-FAT
AB Postprandial hyperlipidaemia is an important feature of diabetic dyslipidaemia and plays an important role in the development of cardiovascular disease in individuals with type 2 diabetes. Postprandial hyperlipidaemia in type 2 diabetes is secondary to increased chylomicron production by the enterocytes and delayed catabolism of chylomicrons and chylomicron remnants. Insulin and some intestinal hormones (e.g. glucagon-like peptide-1 [GLP-1]) influence intestinal lipid metabolism. In individuals with type 2 diabetes, insulin resistance and possibly reduced GLP-1 secretion are involved in the pathophysiology of postprandial hyperlipidaemia. Several factors are involved in the overproduction of chylomicrons: (1) increased expression of microsomal triglyceride transfer protein, which is a key enzyme in chylomicron synthesis; (2) higher stability and availability of apolipoprotein B-48; and (3) increased de novo lipogenesis. Individuals with type 2 diabetes present with disorders of cholesterol metabolism in the enterocytes with reduced absorption and increased synthesis. The increased production of chylomicrons in type 2 diabetes is also associated with a reduction in their catabolism, mostly because of a reduction in activity of lipoprotein lipase. Modification of the microbiota, which is observed in type 2 diabetes, may also generate disorders of intestinal lipid metabolism, but human data remain limited. Some glucose-lowering treatments significantly influence intestinal lipid absorption and transport. Postprandial hyperlipidaemia is reduced by metformin, pioglitazone, alpha-glucosidase inhibitors, dipeptidyl peptidase 4 inhibitors and GLP-1 agonists. The most pronounced effect is observed with GLP-1 agonists, which reduce chylomicron production significantly in individuals with type 2 diabetes and have a direct effect on the intestine by reducing the expression of genes involved in intestinal lipoprotein metabolism. The effect of sodium-glucose cotransporter 2 inhibitors on intestinal lipid metabolism needs to be clarified.
C1 [Verges, Bruno] Univ Hosp, Endocrinol Diabetol Dept, Dijon, France.
   [Verges, Bruno] Univ Burgundy Franche Comte, Med Sch, Inserm UMR 1231, Dijon, France.
C3 CHU Dijon Bourgogne; Institut Agro; AgroSup Dijon; Institut National de
   la Sante et de la Recherche Medicale (Inserm); Universite de Bourgogne
RP Verges, B (通讯作者)，Univ Hosp, Endocrinol Diabetol Dept, Dijon, France.; Verges, B (通讯作者)，Univ Burgundy Franche Comte, Med Sch, Inserm UMR 1231, Dijon, France.
EM bruno.verges@chu-dijon.fr
CR Al Majali K, 2006, DIABETOLOGIA, V49, P527, DOI 10.1007/s00125-005-0092-4
   Beliard S, 2009, DIABETIC MED, V26, P736, DOI 10.1111/j.1464-5491.2009.02757.x
   Black DD, 2007, AM J PHYSIOL-GASTR L, V293, pG519, DOI 10.1152/ajpgi.00189.2007
   Briand F, 2012, J NUTR, V142, P704, DOI 10.3945/jn.111.153197
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Chait A, 2020, DIABETES, V69, P508, DOI 10.2337/dbi19-0007
   Chan DC, 2003, CLIN SCI, V104, P383, DOI [10.1042/CS20020298, 10.1042/cs1040383]
   Chan DC, 2002, CLIN CHEM, V48, P278
   Chappuis B, 2007, DIABETES-METAB RES, V23, P392, DOI 10.1002/dmrr.715
   Chetiveaux M, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-72323-w
   Cotillard A, 2013, NATURE, V500, P585, DOI 10.1038/nature12480
   Couture P, 2014, J LIPID RES, V55, P128, DOI 10.1194/jlr.M040071
   Creely SJ, 2007, AM J PHYSIOL-ENDOC M, V292, pE740, DOI 10.1152/ajpendo.00302.2006
   Curtin A, 1996, ACTA DIABETOL, V33, P205
   Dahl K, 2021, DIABETES OBES METAB, V23, P1594, DOI 10.1111/dom.14373
   Dai Y, 2014, J CARDIOVASC PHARM, V64, P47, DOI 10.1097/FJC.0000000000000087
   Dash S, 2018, DIABETES OBES METAB, V20, P328, DOI 10.1111/dom.13069
   Duez H, 2006, ARTERIOSCL THROM VAS, V26, P1357, DOI 10.1161/01.ATV.0000222015.76038.14
   EBERT R, 1991, HORM METAB RES, V23, P517, DOI 10.1055/s-2007-1003745
   ECKEL RH, 1979, DIABETES, V28, P1141, DOI 10.2337/diabetes.28.12.1141
   Eliasson B, 2012, DIABETOLOGIA, V55, P915, DOI 10.1007/s00125-011-2447-3
   Farr S, 2015, ARTERIOSCL THROM VAS, V35, P1092, DOI 10.1161/ATVBAHA.114.304873
   Federico LM, 2006, DIABETES, V55, P1316, DOI 10.2337/db04-1084
   Giammanco A, 2015, FRONT PHYSIOL, V6, DOI 10.3389/fphys.2015.00061
   Ginsberg HN, 2009, J LIPID RES, V50, pS162, DOI 10.1194/jlr.R800090-JLR200
   Grande EM, 2022, DIABETES, V71, P1388, DOI 10.2337/db21-1053
   Grefhorst Aldo, 2019, Methodist Debakey Cardiovasc J, V15, P70, DOI 10.14797/mdcj-15-1-70
   Guevara-Cruz M, 2019, J AM HEART ASSOC, V8, DOI 10.1161/JAHA.119.012401
   Gutierrez-Repiso C, 2015, LAB INVEST, V95, P1409, DOI 10.1038/labinvest.2015.115
   Gylling H, 1997, DIABETES CARE, V20, P90, DOI 10.2337/diacare.20.1.90
   Haidari M, 2002, J BIOL CHEM, V277, P31646, DOI 10.1074/jbc.M200544200
   HANEFELD M, 1991, DIABETES CARE, V14, P732, DOI 10.2337/diacare.14.8.732
   Harbis A, 2001, DIABETES, V50, P462, DOI 10.2337/diabetes.50.2.462
   Hein GJ, 2013, DIABETES, V62, P373, DOI 10.2337/db12-0202
   Hermansen K, 2013, DIABETES OBES METAB, V15, P1040, DOI 10.1111/dom.12133
   Hogue JC, 2007, J LIPID RES, V48, P1336, DOI 10.1194/jlr.M600548-JLR200
   Hsieh J, 2010, DIABETOLOGIA, V53, P552, DOI 10.1007/s00125-009-1611-5
   Hsieh J, 2015, ENDOCRINOLOGY, V156, P3538, DOI 10.1210/EN.2015-1110
   Hsieh J, 2009, GASTROENTEROLOGY, V137, P997, DOI 10.1053/j.gastro.2009.05.051
   Hussain MM, 2014, CURR OPIN LIPIDOL, V25, P200, DOI 10.1097/MOL.0000000000000084
   Iqbal J, 2009, AM J PHYSIOL-ENDOC M, V296, pE1183, DOI 10.1152/ajpendo.90899.2008
   Jakulj L, 2016, CELL METAB, V24, P783, DOI 10.1016/j.cmet.2016.10.001
   James AP, 2005, DIABETES OBES METAB, V7, P381, DOI 10.1111/j.1463-1326.2004.00407.x
   JEPPESEN J, 1994, DIABETES CARE, V17, P1093, DOI 10.2337/diacare.17.10.1093
   JEPPESEN J, 1994, DIABETOLOGIA, V37, P781, DOI 10.1007/BF00404335
   Jin YX, 2016, TOXICOL SCI, V154, P140, DOI 10.1093/toxsci/kfw150
   Kamijo Y, 2019, CLIN MED INSIGHTS-EN, V12, DOI 10.1177/1179551419866811
   Kim SJ, 2010, J LIPID RES, V51, P3145, DOI 10.1194/jlr.M006841
   Koffert J, 2018, DIABETES OBES METAB, V20, P1384, DOI 10.1111/dom.13228
   Kooijman S, 2015, DIABETOLOGIA, V58, P2637, DOI 10.1007/s00125-015-3727-0
   Kumar NS, 1999, AM J PHYSIOL-GASTR L, V276, pG378, DOI 10.1152/ajpgi.1999.276.2.G378
   Lally S, 2007, ATHEROSCLEROSIS, V193, P343, DOI 10.1016/j.atherosclerosis.2006.09.031
   Lally S, 2006, DIABETOLOGIA, V49, P1008, DOI 10.1007/s00125-006-0177-8
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Le Chatelier E, 2013, NATURE, V500, P541, DOI 10.1038/nature12506
   Levy E, 1996, FEBS LETT, V393, P253, DOI 10.1016/0014-5793(96)00896-4
   Lewis GF, 2005, ENDOCRINOLOGY, V146, P247, DOI 10.1210/en.2004-1143
   Li X, 2019, J FUNCT FOODS, V59, P242, DOI 10.1016/j.jff.2019.05.032
   Lim S, 2021, CLIN NUTR, V40, P5538, DOI 10.1016/j.clnu.2021.09.004
   LIN MCM, 1995, J LIPID RES, V36, P1073
   Malhotra P, 2013, AM J PHYSIOL-GASTR L, V304, pG203, DOI 10.1152/ajpgi.00288.2012
   Mamo JCL, 2001, AM J PHYSIOL-ENDOC M, V281, pE626, DOI 10.1152/ajpendo.2001.281.3.E626
   Mansbach CM, 2007, AM J PHYSIOL-GASTR L, V293, pG645, DOI 10.1152/ajpgi.00299.2007
   Matikainen N, 2006, DIABETOLOGIA, V49, P2049, DOI 10.1007/s00125-006-0340-2
   Meier JJ, 2006, DIABETOLOGIA, V49, P452, DOI 10.1007/s00125-005-0126-y
   Mieszczanska H, 2007, J THROMB HAEMOST, V5, P942, DOI 10.1111/j.1538-7836.2007.02442.x
   Nahmias A, 2021, ARTERIOSCL THROM VAS, V41, P1893, DOI 10.1161/ATVBAHA.121.316311
   Nakano T, 2009, METABOLISM, V58, P583, DOI 10.1016/j.metabol.2009.02.003
   Nogueira JP, 2012, ARTERIOSCL THROM VAS, V32, P1039, DOI 10.1161/ATVBAHA.111.242073
   Ogawa S, 2004, DIABETES OBES METAB, V6, P384, DOI 10.1111/j.1462-8902.2004.00362.x
   Ooi EMM, 2009, DIABETES RES CLIN PR, V85, P310, DOI 10.1016/j.diabres.2009.06.003
   Pavlic M, 2010, DIABETES, V59, P580, DOI 10.2337/db09-1297
   Phillips C, 2002, ATHEROSCLEROSIS, V160, P355, DOI 10.1016/S0021-9150(01)00721-3
   Phillips C, 2006, ATHEROSCLEROSIS, V187, P57, DOI 10.1016/j.atherosclerosis.2005.08.020
   Preiss D, 2017, DIABETES OBES METAB, V19, P356, DOI 10.1111/dom.12826
   Qin XF, 2005, AM J PHYSIOL-GASTR L, V288, pG943, DOI 10.1152/ajpgi.00303.2004
   Ranganath LR, 1999, HORM METAB RES, V31, P262, DOI 10.1055/s-2007-978729
   Sasase T, 2007, DIABETES RES CLIN PR, V78, P8, DOI 10.1016/j.diabres.2007.02.020
   Sato D, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18061282
   Sato H, 2016, GASTROENTEROLOGY, V151, P923, DOI 10.1053/j.gastro.2016.07.009
   Sawada T, 2020, J ATHEROSCLER THROMB, V27, P644, DOI 10.5551/jat.50807
   Shojaee-Moradie F, 2013, DIABETES, V62, P4063, DOI 10.2337/db13-0935
   Simonen PP, 2002, DIABETES CARE, V25, P1511, DOI 10.2337/diacare.25.9.1511
   Stahl A, 2001, TRENDS ENDOCRIN MET, V12, P266, DOI 10.1016/S1043-2760(01)00427-1
   Taskinen MR, 2021, DIABETES OBES METAB, V23, P1191, DOI 10.1111/dom.14328
   Thomas C, 2009, CELL METAB, V10, P167, DOI 10.1016/j.cmet.2009.08.001
   Thondam SK, 2017, AM J PHYSIOL-ENDOC M, V312, pE224, DOI 10.1152/ajpendo.00347.2016
   Tolhurst G, 2012, DIABETES, V61, P364, DOI 10.2337/db11-1019
   Tremblay AJ, 2011, DIABETES OBES METAB, V13, P366, DOI 10.1111/j.1463-1326.2011.01362.x
   Vakkilainen J, 2002, DIABETES-METAB RES, V18, P484, DOI 10.1002/dmrr.324
   Van Wijk JPH, 2005, DIABETES CARE, V28, P844, DOI 10.2337/diacare.28.4.844
   Varin EM, 2020, JCI INSIGHT, V5, DOI 10.1172/jci.insight.140418
   Varin EM, 2019, CELL REP, V27, P3371, DOI 10.1016/j.celrep.2019.05.055
   Veilleux A, 2014, ARTERIOSCL THROM VAS, V34, P644, DOI 10.1161/ATVBAHA.113.302993
   Verges B, 2018, ARTERIOSCL THROM VAS, V38, P2198, DOI 10.1161/ATVBAHA.118.310990
   Verges B, 2015, DIABETOLOGIA, V58, P886, DOI 10.1007/s00125-015-3525-8
   Verges B, 2010, ATHEROSCLEROSIS, V211, P353, DOI 10.1016/j.atherosclerosis.2010.01.028
   Voukali M, 2014, J DIABETES RES, V2014, DOI 10.1155/2014/304032
   Wang J, 2015, J LIPID RES, V56, P319, DOI 10.1194/jlr.M054544
   Wang LJ, 2012, BBA-MOL CELL BIOL L, V1821, P964, DOI 10.1016/j.bbalip.2012.03.004
   WASADA T, 1981, J CLIN INVEST, V68, P1106, DOI 10.1172/JCI110335
   Whyte MB, 2019, J CLIN ENDOCR METAB, V104, P359, DOI 10.1210/jc.2018-01176
   Wong ATY, 2014, J CLIN ENDOCR METAB, V99, pE122, DOI 10.1210/jc.2013-2477
   Xiao CT, 2020, FRONT PHYSIOL, V10, DOI 10.3389/fphys.2019.01604
   Xiao CT, 2019, DIABETES OBES METAB, V21, P2535, DOI 10.1111/dom.13839
   Xiao CT, 2016, ARTERIOSCL THROM VAS, V36, P1457, DOI 10.1161/ATVBAHA.115.307044
   Xiao CT, 2014, DIABETES, V63, P2394, DOI 10.2337/db13-1654
   Xiao CT, 2013, ARTERIOSCL THROM VAS, V33, P1056, DOI 10.1161/ATVBAHA.112.300769
   Xiao CT, 2012, ARTERIOSCL THROM VAS, V32, P1513, DOI 10.1161/ATVBAHA.112.246207
   Xiao CT, 2011, DIABETES, V60, P383, DOI 10.2337/db10-0763
   Zoltowska M, 2003, DIABETES, V52, P2539, DOI 10.2337/diabetes.52.10.2539
NR 111
TC 2
Z9 2
U1 3
U2 8
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0012-186X
EI 1432-0428
J9 DIABETOLOGIA
JI Diabetologia
PD OCT
PY 2022
VL 65
IS 10
BP 1587
EP 1600
DI 10.1007/s00125-022-05765-8
EA JUL 2022
PG 14
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 4O6DC
UT WOS:000833467000001
PM 35908083
OA Bronze
DA 2023-06-08
ER

PT J
AU Greco, CM
   Garetto, S
   Montellier, E
   Liu, Y
   Chen, SW
   Baldi, P
   Sassone-Corsi, P
   Lucci, J
AF Greco, Carolina Magdalen
   Garetto, Stefano
   Montellier, Emilie
   Liu, Yu
   Chen, Siwei
   Baldi, Pierre
   Sassone-Corsi, Paolo
   Lucci, Jacopo
TI A non-pharmacological therapeutic approach in the gut triggers distal
   metabolic rewiring capable of ameliorating diet-induced dysfunctions
   encompassed by metabolic syndrome
SO SCIENTIFIC REPORTS
LA English
DT Article
ID HIGH-FAT DIET; CIRCADIAN CLOCK; INTESTINAL MICROBIOTA; METFORMIN ALTERS;
   OBESITY; INSULIN; LIVER; MOUSE; MODEL; NUTRITION
AB Metabolic syndrome has increased at a worrisome level. Lifestyle changes are not sufficient to prevent and improve the adverse effects of obesity, thus novel interventions are necessary. The aim of this study was to investigate the use and metabolic outcomes of a non-pharmacological intervention in a high-fat diet (HFD) fed mouse model, capable of recapitulating key aspects of metabolic syndrome. We show that Policaptil Gel Retard has remarkable, beneficial effects on metabolic dysfunction caused by consumption of HFD. We describe the mechanism by which such effects are obtained, highlighting the fact that the amelioration of metabolic function observed upon Policaptil Gel Retard administration is profound and of systemic nature, despite being originated by sequestering, therefore non-pharmacological events elicited in the gut lumen.
C1 [Greco, Carolina Magdalen; Montellier, Emilie; Sassone-Corsi, Paolo] Univ Calif Irvine UCI, Sch Med, Ctr Epigenet & Metab, Dept Biol Chem,INSERM,U1233, Irvine, CA 92697 USA.
   [Garetto, Stefano; Lucci, Jacopo] Nat Biomed SpA, Loc Aboca 20, I-52037 Sansepolcro, AR, Italy.
   [Garetto, Stefano; Lucci, Jacopo] Aboca SpA Soc Agr, Innovat & Med Sci Div, Loc Aboca 20, I-52037 Sansepolcro, AR, Italy.
   [Liu, Yu; Chen, Siwei; Baldi, Pierre] UCI, Inst Genom & Bioinformat, Dept Comp Sci, Irvine, CA 92697 USA.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   University of California System; University of California Irvine;
   University of California System; University of California Irvine
RP Sassone-Corsi, P (通讯作者)，Univ Calif Irvine UCI, Sch Med, Ctr Epigenet & Metab, Dept Biol Chem,INSERM,U1233, Irvine, CA 92697 USA.; Lucci, J (通讯作者)，Nat Biomed SpA, Loc Aboca 20, I-52037 Sansepolcro, AR, Italy.; Lucci, J (通讯作者)，Aboca SpA Soc Agr, Innovat & Med Sci Div, Loc Aboca 20, I-52037 Sansepolcro, AR, Italy.
EM psc@uci.edu; JLucci@naturalbiomedicine.it
RI Greco, Carolina/G-1882-2019; Garetto, Stefano/ABD-1709-2020; Greco,
   Carolina/GZG-2761-2022; Montellier, Emilie/ABE-9802-2020; Liu,
   Yu/C-3867-2016; Montellier, Emilie/N-4071-2017
OI Greco, Carolina/0000-0002-9895-5635; Montellier,
   Emilie/0000-0001-5069-3536; Liu, Yu/0000-0003-3698-4892; Garetto,
   Stefano/0000-0002-2421-3356
CR Allen NE, 2003, CANCER CAUSE CONTROL, V14, P65, DOI 10.1023/A:1022518321634
   Asher G, 2015, CELL, V161, P84, DOI 10.1016/j.cell.2015.03.015
   Backhed F, 2004, P NATL ACAD SCI USA, V101, P15718, DOI 10.1073/pnas.0407076101
   Bauer PV, 2018, CELL METAB, V27, P101, DOI 10.1016/j.cmet.2017.09.019
   Biddle A., 2013, DIVERSITY-BASEL, V5, P627, DOI [10.3390/d5030627, DOI 10.3390/d5030627]
   Birkenfeld AL, 2014, HEPATOLOGY, V59, P713, DOI 10.1002/hep.26672
   Bolger AM, 2014, BIOINFORMATICS, V30, P2114, DOI 10.1093/bioinformatics/btu170
   Brockman DA, 2014, J NUTR, V144, P1415, DOI 10.3945/jn.114.191577
   Carter S, 2014, ATHEROSCLEROSIS, V237, P645, DOI 10.1016/j.atherosclerosis.2014.09.022
   Chen EY, 2013, BMC BIOINFORMATICS, V14, DOI 10.1186/1471-2105-14-128
   Eckel-Mahan KL, 2013, CELL, V155, P1464, DOI 10.1016/j.cell.2013.11.034
   Feingold EA, 2004, SCIENCE, V306, P636, DOI 10.1126/science.1105136
   Greco CM, 2019, NAT REV NEUROSCI, V20, P71, DOI 10.1038/s41583-018-0096-y
   Guan DY, 2018, CELL, V174, P831, DOI 10.1016/j.cell.2018.06.031
   Halade GV, 2010, J NUTR BIOCHEM, V21, P1162, DOI 10.1016/j.jnutbio.2009.10.002
   Hedbacker K, 2010, CELL METAB, V11, P11, DOI 10.1016/j.cmet.2009.11.007
   Johnson AMF, 2013, CELL, V152, P673, DOI 10.1016/j.cell.2013.01.041
   Kang HS, 2016, SCI REP-UK, V6, DOI 10.1038/srep23665
   Karolchik D, 2003, NUCLEIC ACIDS RES, V31, P51, DOI 10.1093/nar/gkg129
   Keithley JK, 2013, J OBES, V2013, DOI 10.1155/2013/610908
   Kinouchi K, 2018, CELL REP, V25, P3299, DOI 10.1016/j.celrep.2018.11.077
   Kozich JJ, 2013, APPL ENVIRON MICROB, V79, P5112, DOI 10.1128/AEM.01043-13
   Kramer A, 2014, BIOINFORMATICS, V30, P523, DOI 10.1093/bioinformatics/btt703
   Kristensen M, 2013, NUTRIENTS, V5, P3287, DOI 10.3390/nu5083287
   Kristensen M, 2012, NUTR METAB, V9, DOI 10.1186/1743-7075-9-8
   Lachmann A, 2010, BIOINFORMATICS, V26, P2438, DOI 10.1093/bioinformatics/btq466
   Leone V, 2015, CELL HOST MICROBE, V17, P681, DOI 10.1016/j.chom.2015.03.006
   Ley RE, 2005, P NATL ACAD SCI USA, V102, P11070, DOI 10.1073/pnas.0504978102
   Ley RE, 2006, NATURE, V444, P1022, DOI 10.1038/4441022a
   Li GL, 2017, CELL METAB, V26, P801, DOI 10.1016/j.cmet.2017.10.007
   Lutsey PL, 2008, CIRCULATION, V117, P754, DOI 10.1161/CIRCULATIONAHA.107.716159
   Maury E, 2010, CIRC RES, V106, P447, DOI 10.1161/CIRCRESAHA.109.208355
   McCleary BV, 2001, ADV DIETARY FIBRE TE
   Mercati V, 2006, EU patent, Patent No. [EP1679009, 1679009]
   Murakami M, 2016, EMBO REP, V17, P1292, DOI 10.15252/embr.201642463
   Nam SY, 1997, INT J OBESITY, V21, P355, DOI 10.1038/sj.ijo.0800412
   Nolan CJ, 2011, LANCET, V378, P169, DOI 10.1016/S0140-6736(11)60614-4
   Otles S, 2014, ACTA SCI POLON-TECHN, V13, P191, DOI 10.17306/J.AFS.2014.2.8
   Panahi S, 2007, J AM COLL NUTR, V26, P639, DOI 10.1080/07315724.2007.10719641
   Panda S, 2016, SCIENCE, V354, P1008, DOI 10.1126/science.aah4967
   Renehan AG, 2006, TRENDS ENDOCRIN MET, V17, P328, DOI 10.1016/j.tem.2006.08.006
   Ridaura VK, 2013, SCIENCE, V341, P1079, DOI 10.1126/science.1241214
   Segata N, 2011, GENOME BIOL, V12, DOI 10.1186/gb-2011-12-6-r60
   Semova I, 2012, CELL HOST MICROBE, V12, P277, DOI 10.1016/j.chom.2012.08.003
   Stagi S, 2017, NUTRIENTS, V9, DOI 10.3390/nu9050524
   Stagi S, 2015, ITAL J PEDIATR, V41, DOI 10.1186/s13052-015-0109-7
   Sun LJ, 2018, PROTEIN CELL, V9, P397, DOI 10.1007/s13238-018-0546-3
   Sun LL, 2018, NAT MED, V24, P1919, DOI 10.1038/s41591-018-0222-4
   Turnbaugh PJ, 2008, CELL HOST MICROBE, V3, P213, DOI 10.1016/j.chom.2008.02.015
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   VidalPuig A, 1996, J CLIN INVEST, V97, P2553, DOI 10.1172/JCI118703
   Vita P M, 1992, Minerva Med, V83, P135
   Wang S, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-31353-1
   Wheatcroft SB, 2007, DIABETES, V56, P285, DOI 10.2337/db06-0436
   Winzell MS, 2004, DIABETES, V53, pS215, DOI 10.2337/diabetes.53.suppl_3.S215
   Wong SK, 2016, NUTR METAB, V13, DOI 10.1186/s12986-016-0123-9
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Xu F, 2013, MOL MED REP, V8, P823, DOI 10.3892/mmr.2013.1572
   Zhang M, 2016, WORLD J GASTROENTERO, V22, P8905, DOI 10.3748/wjg.v22.i40.8905
   Zietak M, 2017, BIOCHIMIE, V134, P93, DOI 10.1016/j.biochi.2016.12.006
   Zivkovic AM, 2007, AM J CLIN NUTR, V86, P285, DOI 10.1093/ajcn/86.2.285
NR 61
TC 3
Z9 3
U1 2
U2 4
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JUL 31
PY 2020
VL 10
IS 1
AR 12915
DI 10.1038/s41598-020-69469-y
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA MV5QB
UT WOS:000556411200014
PM 32737396
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Huang, J
   Liu, CC
   Yang, Y
   Kang, DY
   Xiao, JM
   Long, YJ
   Lang, B
   Peng, XJ
   Wang, WY
   Wang, XY
   Liu, FK
   Zhao, JP
   Shi, Z
   Yuan, TF
   Wu, RR
AF Huang, Jing
   Liu, Chenchen
   Yang, Ye
   Kang, Dongyu
   Xiao, Jingmei
   Long, Yujun
   Lang, Bing
   Peng, Xingjie
   Wang, Weiyan
   Wang, Xiaoyi
   Liu, Fangkun
   Zhao, Jingping
   Shi, Zhe
   Yuan, Ti-Fei
   Wu, Renrong
TI The effects of probiotics plus dietary fiber on antipsychotic-induced
   weight gain: a randomized clinical trial
SO TRANSLATIONAL PSYCHIATRY
LA English
DT Article
ID GUT MICROBIOME; SCHIZOPHRENIA; RISPERIDONE; OVERWEIGHT; METFORMIN;
   BACTERIA; DISEASE; OBESITY; HEALTH; RISK
AB Probiotics plus dietary fiber has demonstrated efficacy in improving metabolic abnormalities. However, the efficacy of probiotics and dietary fiber as well as their association with microbiota in attenuating antipsychotic-induced weight gain and metabolic disturbance remains poorly understood. Here we analyzed results from the double-blind, randomized, placebo-controlled study to compare and evaluate the effects of probiotics, dietary fiber, and their combination for antipsychotic-induced weight gain in patients with a severe mental disorder. We found that probiotics plus dietary fiber was significantly superior to probiotics alone, dietary fiber only, and the placebo for weight, BMI, and total cholesterol reduction; insulin resistance was worse in the placebo group, with significant increases during the 12-week treatment; probiotics plus dietary fiber significantly reduced weight and prevented further deterioration of metabolic disturbances; and probiotics or dietary fiber alone can prevent further weight gain. We further performed 16 S ribosomal RNA sequencing revealed an increased abundance of microbiota after probiotics plus dietary fiber treatment. Moreover, logistic regression analyses revealed that the higher richness of microbiota was associated with favorable weight loss. These findings suggested that probiotics and dietary fiber co-administration were safe and effective interventions to reduce weight gain in patients treated with antipsychotic medications.
C1 [Huang, Jing; Liu, Chenchen; Yang, Ye; Kang, Dongyu; Xiao, Jingmei; Long, Yujun; Lang, Bing; Peng, Xingjie; Wang, Weiyan; Wang, Xiaoyi; Zhao, Jingping; Shi, Zhe; Wu, Renrong] Cent South Univ, Xiangya Hosp 2, Dept Psychiat, Changsha 410011, Hunan, Peoples R China.
   [Huang, Jing; Liu, Chenchen; Yang, Ye; Kang, Dongyu; Xiao, Jingmei; Long, Yujun; Lang, Bing; Peng, Xingjie; Wang, Weiyan; Wang, Xiaoyi; Zhao, Jingping; Shi, Zhe; Wu, Renrong] Cent South Univ, Xiangya Hosp 2, Natl Clin Res Ctr Mental Disorders, Changsha 410011, Hunan, Peoples R China.
   [Liu, Fangkun] Cent South Univ, Xiangya Hosp, Dept Neurosurg, Changsha 410008, Hunan, Peoples R China.
   [Shi, Zhe] Hunan Univ Chinese Med, Key Lab Qual Evaluat Bulk Herbs Hunan Prov, Changsha 410208, Hunan, Peoples R China.
   [Shi, Zhe; Yuan, Ti-Fei] Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Shanghai Key Lab Psychot Disorders, Sch Med, Shanghai, Peoples R China.
   [Yuan, Ti-Fei] Nantong Univ, Coinnovat Ctr Neuroregenerat, Nantong, Peoples R China.
   [Yuan, Ti-Fei] Tongji Univ, Sch Med, Shanghai Peoples Hosp 4, Translat Res Inst Brain & Brain Intelligence, Shanghai, Peoples R China.
C3 Central South University; Central South University; Central South
   University; Hunan University of Chinese Medicine; Shanghai Jiao Tong
   University; Nantong University; Tongji University
RP Wu, RR (通讯作者)，Cent South Univ, Xiangya Hosp 2, Dept Psychiat, Changsha 410011, Hunan, Peoples R China.; Wu, RR (通讯作者)，Cent South Univ, Xiangya Hosp 2, Natl Clin Res Ctr Mental Disorders, Changsha 410011, Hunan, Peoples R China.; Yuan, TF (通讯作者)，Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Shanghai Key Lab Psychot Disorders, Sch Med, Shanghai, Peoples R China.; Yuan, TF (通讯作者)，Nantong Univ, Coinnovat Ctr Neuroregenerat, Nantong, Peoples R China.; Yuan, TF (通讯作者)，Tongji Univ, Sch Med, Shanghai Peoples Hosp 4, Translat Res Inst Brain & Brain Intelligence, Shanghai, Peoples R China.
EM ytf0707@126.com; wurenrong@csu.edu.cn
RI Zhao, Xujun/IRZ-4119-2023; Kang, Dongyu/HUF-7715-2023
OI Kang, Dongyu/0000-0002-3897-2302
FU Key R&D Program Projects, National Natural Science Foundation of China
   [2016YFC1306900]; National Natural Science Foundation of China
   [82072096, 81622018, 81901401]
FX The trial was supported by the Key R&D Program Projects, National
   Natural Science Foundation of China (Grant No. 2016YFC1306900), and the
   National Natural Science Foundation of China (Grant No. 82072096; Grant
   No. 81622018; Grant No. 81901401). We also want to express our thanks to
   the Shanghai Applied Protein Technology Co.Ltd for 16S rDNA sequencing
   and data analysis.
CR Allison DB, 1999, AM J PSYCHIAT, V156, P1686
   Anderson JW, 2009, NUTR REV, V67, P188, DOI 10.1111/j.1753-4887.2009.00189.x
   Arnoriaga-Rodriguez M, 2020, MICROBIOME, V8, DOI 10.1186/s40168-020-00837-6
   Bahr SM, 2015, TRANSL PSYCHIAT, V5, DOI 10.1038/tp.2015.135
   Bahr SM, 2015, EBIOMEDICINE, V2, P1725, DOI 10.1016/j.ebiom.2015.10.018
   Barichella M, 2016, NEUROLOGY, V87, P1274, DOI 10.1212/WNL.0000000000003127
   Bosch G, 2009, BRIT J NUTR, V102, P318, DOI 10.1017/S0007114508149194
   Cignarella F, 2018, CELL METAB, V27, P1222, DOI 10.1016/j.cmet.2018.05.006
   Davey KJ, 2013, TRANSL PSYCHIAT, V3, DOI 10.1038/tp.2013.83
   Davey KJ, 2012, PSYCHOPHARMACOLOGY, V221, P155, DOI 10.1007/s00213-011-2555-2
   Ghaderi A, 2019, BMC PSYCHIATRY, V19, DOI 10.1186/s12888-019-2059-x
   Hamer HM, 2008, ALIMENT PHARM THER, V27, P104, DOI 10.1111/j.1365-2036.2007.03562.x
   Henderson DC, 2015, LANCET PSYCHIAT, V2, P452, DOI 10.1016/S2215-0366(15)00115-7
   Kao ACC, 2019, SCHIZOPHR RES, V208, P460, DOI 10.1016/j.schres.2019.03.003
   Kao ACC, 2018, TRANSL PSYCHIAT, V8, DOI 10.1038/s41398-018-0116-8
   Kassaian N, 2018, ACTA DIABETOL, V55, P1019, DOI 10.1007/s00592-018-1175-2
   Kijmanawat A, 2019, J DIABETES INVEST, V10, P163, DOI 10.1111/jdi.12863
   Koliada A, 2017, BMC MICROBIOL, V17, DOI 10.1186/s12866-017-1027-1
   Krumbeck JA, 2018, MICROBIOME, V6, DOI 10.1186/s40168-018-0494-4
   Laursen TM, 2012, CURR OPIN PSYCHIATR, V25, P83, DOI 10.1097/YCO.0b013e32835035ca
   Le Chatelier E, 2013, NATURE, V500, P541, DOI 10.1038/nature12506
   Leigh SJ, 2020, TRANSL PSYCHIAT, V10, DOI 10.1038/s41398-020-0774-1
   Ley RE, 2006, NATURE, V444, P1022, DOI 10.1038/4441022a
   Liu CC, 2021, TRIALS, V22, DOI 10.1186/s13063-021-05123-w
   Liu RX, 2017, NAT MED, V23, P859, DOI 10.1038/nm.4358
   Ludwig DS, 1999, JAMA-J AM MED ASSOC, V282, P1539, DOI 10.1001/jama.282.16.1539
   Marchesi JR, 2016, GUT, V65, P330, DOI 10.1136/gutjnl-2015-309990
   Marder SR, 1997, J CLIN PSYCHIAT, V58, P538, DOI 10.4088/JCP.v58n1205
   McQuade JL, 2019, LANCET ONCOL, V20, pE77, DOI 10.1016/S1470-2045(18)30952-5
   Morgan AP, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0115225
   Parnell JA, 2009, AM J CLIN NUTR, V89, P1751, DOI 10.3945/ajcn.2009.27465
   Rajkumar H, 2015, J CARDIOVASC PHARM T, V20, P289, DOI 10.1177/1074248414555004
   Riva A, 2020, FRONT MICROBIOL, V11, DOI 10.3389/fmicb.2020.585428
   Stenman LK, 2016, EBIOMEDICINE, V13, P190, DOI 10.1016/j.ebiom.2016.10.036
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Vandeputte D, 2017, GUT, V66, P1968, DOI 10.1136/gutjnl-2016-313271
   Wu RR, 2016, MOL PSYCHIATR, V21, P1537, DOI 10.1038/mp.2015.221
   Wu RR, 2008, JAMA-J AM MED ASSOC, V299, P185, DOI 10.1001/jama.2007.56-b
   Wu TR, 2019, GUT, V68, P248, DOI 10.1136/gutjnl-2017-315458
   Yang JJ, 2020, JAMA ONCOL, V6, DOI 10.1001/jamaoncol.2019.4107
   Zhang CH, 2010, ISME J, V4, P232, DOI 10.1038/ismej.2009.112
   Zhao LP, 2018, SCIENCE, V359, P1151, DOI 10.1126/science.aao5774
NR 42
TC 5
Z9 5
U1 8
U2 18
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 2158-3188
J9 TRANSL PSYCHIAT
JI Transl. Psychiatr.
PD MAY 4
PY 2022
VL 12
IS 1
AR 185
DI 10.1038/s41398-022-01958-2
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA 0Z0HR
UT WOS:000790762400003
PM 35508529
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Liu, Y
   Qin, ST
   Feng, Y
   Song, YL
   Lv, N
   Liu, F
   Zhang, XM
   Wang, SX
   Wei, YM
   Li, S
   Su, SP
   Zhang, WY
   Xue, Y
   Hao, YN
   Zhu, BL
   Ma, JM
   Yang, HX
AF Liu, Yu
   Qin, Shengtang
   Feng, Ye
   Song, Yilin
   Lv, Na
   Liu, Fei
   Zhang, Xiaoming
   Wang, Shuxian
   Wei, Yumei
   Li, Shuang
   Su, Shiping
   Zhang, Wanyi
   Xue, Yong
   Hao, Yanan
   Zhu, Baoli
   Ma, Jingmei
   Yang, Huixia
TI Perturbations of gut microbiota in gestational diabetes mellitus
   patients induce hyperglycemia in germ-free mice
SO JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
LA English
DT Article; Proceedings Paper
CT 11th World Congress of Developmental Origins of Health and Disease
   (DOHaD)
CY OCT 20-23, 2019
CL Melbourne, AUSTRALIA
DE Gestational diabetes mellitus (GDM); gut microbiota; germ-free mice;
   fecal microbiota transplantation
ID CHAIN FATTY-ACIDS; AKKERMANSIA-MUCINIPHILA; METFORMIN; GLUCOSE; MOTHER;
   WOMEN; RISK
AB Shifts in the maternal gut microbiota have been implicated in the development of gestational diabetes mellitus (GDM). Understanding the interaction between gut microbiota and host glucose metabolism will provide a new target of prediction and treatment. In this nested case-control study, we aimed to investigate the causal effects of gut microbiota from GDM patients on the glucose metabolism of germ-free (GF) mice. Stool and peripheral blood samples, as well as clinical information, were collected from 45 GDM patients and 45 healthy controls (matched by age and prepregnancy body mass index (BMI)) in the first and second trimester. Gut microbiota profiles were explored by next-generation sequencing of the 16S rRNA gene, and inflammatory factors in peripheral blood were analyzed by enzyme-linked immunosorbent assay. Fecal samples from GDM and non-GDM donors were transferred to GF mice. The gut microbiota of women with GDM showed reduced richness, specifically decreased Bacteroides and Akkermansia, as well as increased Faecalibacterium. The relative abundance of Akkermansia was negatively associated with blood glucose levels, and the relative abundance of Faecalibacterium was positively related to inflammatory factor concentrations. The transfer of fecal microbiota from GDM and non-GDM donors to GF mice resulted in different gut microbiota colonization patterns, and hyperglycemia was induced in mice that received GDM donor microbiota. These results suggested that the shifting pattern of gut microbiota in GDM patients contributed to disease pathogenesis.
C1 [Liu, Yu; Qin, Shengtang; Feng, Ye; Song, Yilin; Zhang, Xiaoming; Wang, Shuxian; Wei, Yumei; Li, Shuang; Su, Shiping; Zhang, Wanyi; Ma, Jingmei; Yang, Huixia] Peking Univ First Hosp, Dept Obstet & Gynaecol, Beijing, Peoples R China.
   [Liu, Yu; Qin, Shengtang; Feng, Ye; Song, Yilin; Zhang, Xiaoming; Wang, Shuxian; Wei, Yumei; Li, Shuang; Su, Shiping; Zhang, Wanyi; Ma, Jingmei; Yang, Huixia] Beijing Key Lab Maternal Foetal Med Gestat Diabet, Beijing, Peoples R China.
   [Liu, Yu; Qin, Shengtang; Feng, Ye; Song, Yilin; Zhang, Xiaoming; Wang, Shuxian; Wei, Yumei; Li, Shuang; Su, Shiping; Zhang, Wanyi; Ma, Jingmei; Yang, Huixia] Peking Univ, Beijing, Peoples R China.
   [Lv, Na; Liu, Fei; Xue, Yong; Hao, Yanan; Zhu, Baoli] Chinese Acad Sci, Inst Microbiol, Beijing, Peoples R China.
C3 Peking University; Chinese Academy of Sciences; Institute of
   Microbiology, CAS
RP Ma, JM; Yang, HX (通讯作者)，Peking Univ First Hosp, Dept Obstet & Gynaecol, Beijing, Peoples R China.; Ma, JM; Yang, HX (通讯作者)，Beijing Key Lab Maternal Foetal Med Gestat Diabet, Beijing, Peoples R China.; Ma, JM; Yang, HX (通讯作者)，Peking Univ, Beijing, Peoples R China.; Zhu, BL (通讯作者)，Chinese Acad Sci, Inst Microbiol, Beijing, Peoples R China.
EM zhubaoli@im.ac.cn; jingmeima@bjmu.edu.cn; yanghuixia@bjmu.edu.cn
RI Ma, Jingmei/GLS-7998-2022
OI liu, fei/0000-0003-1175-4070
FU National Natural Science Foundation of China [81671483, 81830044];
   Beijing Natural Science Foundation [7171011, S150002]; National Key
   Technologies RD Program [2016YFC1000303]; Key Research Program of the
   Chinese Academy of Sciences [KFZD-SW-219]
FX This work was supported by the National Natural Science Foundation of
   China (81671483, 81830044), Beijing Natural Science Foundation (7171011,
   S150002), National Key Technologies R&D Program (2016YFC1000303), and
   Key Research Program of the Chinese Academy of Sciences (KFZD-SW-219).
CR [Anonymous], 2018, POST REPROD HLTH, V24, P133
   Backhed F, 2007, P NATL ACAD SCI USA, V104, P979, DOI 10.1073/pnas.0605374104
   Canfora EE, 2015, NAT REV ENDOCRINOL, V11, P577, DOI 10.1038/nrendo.2015.128
   Cani PD, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.01765
   CHAO A, 1984, SCAND J STAT, V11, P265
   Cho I, 2012, NAT REV GENET, V13, P260, DOI 10.1038/nrg3182
   Cortez RV, 2019, ENDOCRINE, V64, P254, DOI 10.1007/s12020-018-1813-z
   Crusell MKW, 2018, MICROBIOME, V6, DOI 10.1186/s40168-018-0472-x
   Damm P, 2016, DIABETOLOGIA, V59, P1396, DOI 10.1007/s00125-016-3985-5
   Dao MC, 2016, GUT, V65, P426, DOI 10.1136/gutjnl-2014-308778
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Depommier C, 2019, NAT MED, V25, P1096, DOI 10.1038/s41591-019-0495-2
   Edwards SM, 2017, MCN-AM J MATERN-CHIL, V42, P310, DOI 10.1097/NMC.0000000000000372
   Enquobahrie DA, 2005, DIABETES RES CLIN PR, V70, P134, DOI 10.1016/j.diabres.2005.03.022
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Fugmann M, 2015, SCI REP-UK, V5, DOI 10.1038/srep13212
   Goodrich JK, 2014, CELL, V159, P789, DOI 10.1016/j.cell.2014.09.053
   Ihaka R., 1996, J COMPUTATIONAL GRAP, V5, P299, DOI [DOI 10.1080/10618600.1996.10474713, 10.2307/1390807]
   India State Level Disease Burden Initiative Road Injury Collaborators, 2020, LANCET PUBLIC HEALTH, V5, pe86, DOI DOI 10.1128/MSYSTEMS.00109-20
   Jenmalm MC, 2017, J INTERN MED, V282, P484, DOI 10.1111/joim.12652
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Koren O, 2012, CELL, V150, P470, DOI 10.1016/j.cell.2012.07.008
   Krebs C.J., 1998, ECOLOGICAL METHODOLO
   Kuang YS, 2017, GIGASCIENCE, V6, DOI 10.1093/gigascience/gix058
   Lauenborg J, 2004, DIABETES CARE, V27, P1194, DOI 10.2337/diacare.27.5.1194
   Le Chatelier E, 2013, NATURE, V500, P541, DOI 10.1038/nature12506
   Lee H, 2018, GUT MICROBES, V9, P155, DOI 10.1080/19490976.2017.1405209
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Ley RE, 2006, NATURE, V444, P1022, DOI 10.1038/4441022a
   Lowe WL, 2016, CURR DIABETES REP, V16, DOI 10.1007/s11892-015-0709-z
   Magoc T, 2011, BIOINFORMATICS, V27, P2957, DOI 10.1093/bioinformatics/btr507
   Metzger BE, 2010, DIABETES CARE, V33, P676, DOI 10.2337/dc09-1848
   Newbern D, 2011, CURR OPIN ENDOCRINOL, V18, P409, DOI 10.1097/MED.0b013e32834c800d
   Nicholson JK, 2012, SCIENCE, V336, P1262, DOI 10.1126/science.1223813
   Plovier H, 2017, NAT MED, V23, P107, DOI 10.1038/nm.4236
   Ponzo V, 2019, NUTRIENTS, V11, DOI 10.3390/nu11020330
   Ridaura VK, 2013, SCIENCE, V341, P1079, DOI 10.1126/science.1241214
   Robertson RC, 2019, TRENDS MICROBIOL, V27, P131, DOI 10.1016/j.tim.2018.09.008
   Segata N, 2011, GENOME BIOL, V12, DOI 10.1186/gb-2011-12-6-r60
   SHANNON CE, 1948, BELL SYST TECH J, V27, P623, DOI 10.1002/j.1538-7305.1948.tb00917.x
   Smith PM, 2013, SCIENCE, V341, P569, DOI 10.1126/science.1241165
   Sokol H, 2008, P NATL ACAD SCI USA, V105, P16731, DOI 10.1073/pnas.0804812105
   Wahlstrom A, 2017, J LIPID RES, V58, P412, DOI 10.1194/jlr.M072819
   Wang JF, 2018, GUT, V67, P1614, DOI 10.1136/gutjnl-2018-315988
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Zhu WW, 2013, DIABETES CARE, V36, P586, DOI 10.2337/dc12-1157
NR 46
TC 12
Z9 15
U1 6
U2 30
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 2040-1744
EI 2040-1752
J9 J DEV ORIG HLTH DIS
JI J. Dev. Orig. Health Dis.
PD DEC
PY 2020
VL 11
IS 6
BP 580
EP 588
AR PII S2040174420000768
DI 10.1017/S2040174420000768
PG 9
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Public, Environmental & Occupational Health
GA OQ8PU
UT WOS:000589038900006
PM 32924908
DA 2023-06-08
ER

PT J
AU Eibl, G
   Rozengurt, E
AF Eibl, Guido
   Rozengurt, Enrique
TI KRAS, YAP, and obesity in pancreatic cancer: A signaling network with
   multiple loops
SO SEMINARS IN CANCER BIOLOGY
LA English
DT Review
DE Pancreatic cancer; Oncogenic kras; Obesity; Signaling network; YAP
ID PROTEIN-KINASE-D; COUPLED RECEPTOR AGONISTS; POTENTIATES DNA-SYNTHESIS;
   TYPE-2 DIABETES-MELLITUS; GROWTH IN-VITRO; HIPPO PATHWAY; CELL-LINE;
   HIGH-FAT; DUCTAL ADENOCARCINOMA; MAMMALIAN TARGET
AB Pancreatic ductal adenocarcinoma (PDAC) continues to be a lethal disease with no efficacious treatment modalities. The incidence of PDAC is expected to increase, at least partially because of the obesity epidemic. Increased efforts to prevent or intercept this disease are clearly needed. Mutations in KRAS are initiating events in pancreatic carcinogenesis supported by genetically engineered mouse models of the disease. However, oncogenic KRAS is not entirely sufficient for the development of fully invasive PDAC. Additional genetic mutations and/or environmental, nutritional, and metabolic stressors, e.g. inflammation and obesity, are required for efficient PDAC formation with activation of KRAS downstream effectors. Multiple factors "upstream" of KRAS associated with obesity, including insulin resistance, inflammation, changes in gut microbiota and GI peptides, can enhance/modulate downstream signals. Multiple signaling networks and feedback loops "downstream" of KRAS have been described that respond to obesogenic diets. We propose that KRAS mutations potentiate a signaling network that is promoted by environmental factors. Specifically, we envisage that KRAS mutations increase the intensity and duration of the growth-promoting signaling network. As the transcriptional activator YAP plays a critical role in the network, we conclude that the rationale for targeting the network (at different points), e.g. with FDA approved drugs such as statins and metformin, is therefore compelling.
C1 [Eibl, Guido] Univ Calif Los Angeles, David Geffen Sch Med, Dept Surg, 72-236 CHS,10833 Le Conte Ave, Los Angeles, CA 90095 USA.
   [Rozengurt, Enrique] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA.
   [Eibl, Guido; Rozengurt, Enrique] Univ Calif Los Angeles, CURE Digest Dis Res Ctr, Los Angeles, CA USA.
C3 University of California System; University of California Los Angeles;
   University of California Los Angeles Medical Center; David Geffen School
   of Medicine at UCLA; University of California System; University of
   California Los Angeles; University of California Los Angeles Medical
   Center; David Geffen School of Medicine at UCLA; University of
   California System; University of California Los Angeles
RP Eibl, G (通讯作者)，Univ Calif Los Angeles, David Geffen Sch Med, Dept Surg, 72-236 CHS,10833 Le Conte Ave, Los Angeles, CA 90095 USA.
EM Geibl@mednet.ucla.edu
FU NIH [P01CA163200, R01DK100405, P30DK41301]; Department of Veterans
   Affair Merit Award [1I01BX001473]; Hirshberg Foundation for Pancreatic
   Cancer Research
FX NIH Grant P01CA163200 supported the work of the laboratory of G.E. The
   work in the laboratory of E.R. was supported by NIH Grants R01DK100405,
   P30DK41301 and P01CA163200 and by the Department of Veterans Affair
   Merit Award1I01BX001473. Additional funding for G.E. and E.R.
   laboratories came from the Hirshberg Foundation for Pancreatic Cancer
   Research.
CR Aggarwal G, 2013, PANCREAS, V42, P198, DOI 10.1097/MPA.0b013e3182592c96
   Aguilar D, 2006, DRUGS, V66, P1169, DOI 10.2165/00003495-200666090-00001
   Aguirre AJ, 2003, GENE DEV, V17, P3112, DOI 10.1101/gad.1158703
   Albini A, 2016, CLIN CANCER RES, V22, P4322, DOI 10.1158/1078-0432.CCR-16-0695
   Ali SM, 2005, J BIOL CHEM, V280, P19445, DOI 10.1074/jbc.C500125200
   Allott EH, 2015, ENDOCR-RELAT CANCER, V22, pR365, DOI 10.1530/ERC-15-0400
   ALMOGUERA C, 1988, CELL, V53, P549, DOI 10.1016/0092-8674(88)90571-5
   Alshoukr P, 2009, BIOCONJUGATE CHEM, V20, P1602, DOI 10.1021/bc900151z
   Amin S, 2016, AM J GASTROENTEROL, V111, P1350, DOI 10.1038/ajg.2016.288
   An Y, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0072042
   Arafat HA, 2007, J AM COLL SURGEONS, V204, P996, DOI 10.1016/j.jamcollsurg.2007.01.067
   Armengol G, 2007, CANCER RES, V67, P7551, DOI 10.1158/0008-5472.CAN-07-0881
   Asano T, 2005, CANCER RES, V65, P9164, DOI 10.1158/0008-5472.CAN-05-0779
   Asano T, 2005, BIOCHEM BIOPH RES CO, V331, P295, DOI 10.1016/j.bbrc.2005.03.166
   Aune D, 2012, ANN ONCOL, V23, P843, DOI 10.1093/annonc/mdr398
   Bar-Peled L, 2014, TRENDS CELL BIOL, V24, P400, DOI 10.1016/j.tcb.2014.03.003
   Ben QW, 2011, EUR J CANCER, V47, P1928, DOI 10.1016/j.ejca.2011.03.003
   Ben Sahra I, 2008, ONCOGENE, V27, P3576, DOI 10.1038/sj.onc.1211024
   Ben Sahra I, 2010, MOL CANCER THER, V9, P1092, DOI 10.1158/1535-7163.MCT-09-1186
   Berker B, 2004, GYNECOL ENDOCRINOL, V19, P125, DOI 10.1080/09513590400007309
   Berridge MJ, 2000, NAT REV MOL CELL BIO, V1, P11, DOI 10.1038/35036035
   Biankin AV, 2012, NATURE, V491, P399, DOI 10.1038/nature11547
   Boukalova S, 2016, MOL CANCER THER, V15, P2875, DOI 10.1158/1535-7163.MCT-15-1021
   Bryant KL, 2014, TRENDS BIOCHEM SCI, V39, P91, DOI 10.1016/j.tibs.2013.12.004
   Caer C, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-02660-w
   Campbell PM, 2006, METHOD ENZYMOL, V407, P195, DOI 10.1016/S0076-6879(05)07017-5
   Cancer Genome Atlas Research Network. Electronic address: andrew_aguirre@dfci.harvard.edu, 2017, Cancer Cell, V32, P185, DOI 10.1016/j.ccell.2017.07.007
   Carey FJ, 2013, DIGEST DIS SCI, V58, P3308, DOI 10.1007/s10620-013-2778-7
   Cayrol C, 2006, ONCOGENE, V25, P4421, DOI 10.1038/sj.onc.1209484
   Cerullo M, 2016, J GASTROINTEST SURG, V20, P1572, DOI 10.1007/s11605-016-3173-4
   Chang HH, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0184455
   Chang HH, 2015, AM J PHYSIOL-CELL PH, V309, pC639, DOI 10.1152/ajpcell.00417.2014
   Chen MJ, 2016, INT J CANCER, V138, P594, DOI 10.1002/ijc.29813
   Clendening JW, 2010, P NATL ACAD SCI USA, V107, P15051, DOI 10.1073/pnas.0910258107
   Collins MA, 2012, J CLIN INVEST, V122, P639, DOI 10.1172/JCI59227
   Cui YF, 2012, ENDOCR-RELAT CANCER, V19, pF9, DOI 10.1530/ERC-12-0105
   Cully M, 2014, NAT REV DRUG DISCOV, V13, DOI 10.1038/nrd4372
   Daniluk J, 2012, J CLIN INVEST, V122, P1519, DOI 10.1172/JCI59743
   Dawson DW, 2013, CANCER PREV RES, V6, P1064, DOI 10.1158/1940-6207.CAPR-13-0065
   Deramaudt T, 2005, BBA-REV CANCER, V1756, P97, DOI 10.1016/j.bbcan.2005.08.003
   Di Agostino S, 2016, EMBO REP, V17, P188, DOI 10.15252/embr.201540488
   di Magliano MP, 2013, GASTROENTEROLOGY, V144, P1220, DOI 10.1053/j.gastro.2013.01.071
   DICKER P, 1980, NATURE, V287, P607, DOI 10.1038/287607a0
   Dixon JL, 2016, DIS ESOPHAGUS, V29, P747, DOI 10.1111/dote.12402
   Djuric Z, 2017, TRANSL RES, V179, P155, DOI 10.1016/j.trsl.2016.07.017
   Ehlers RA, 2000, BIOCHEM BIOPH RES CO, V269, P704, DOI 10.1006/bbrc.2000.2335
   Eibl G., 2017, J ACAD NUTR DIET
   El-Mir MY, 2000, J BIOL CHEM, V275, P223, DOI 10.1074/jbc.275.1.223
   Elek J, 2000, ANTICANCER RES, V20, P53
   Enzo E, 2015, EMBO J, V34, P1349, DOI 10.15252/embj.201490379
   Evans JMM, 2005, BMJ-BRIT MED J, V330, P1304, DOI 10.1136/bmj.38415.708634.F7
   Exton JH, 1996, ANNU REV PHARMACOL, V36, P481, DOI 10.1146/annurev.pa.36.040196.002405
   Fan R, 2013, P NATL ACAD SCI USA, V110, P2569, DOI 10.1073/pnas.1216462110
   Feng ZH, 2010, CSH PERSPECT BIOL, V2, DOI 10.1101/cshperspect.a001057
   Feng ZH, 2010, TRENDS CELL BIOL, V20, P427, DOI 10.1016/j.tcb.2010.03.004
   Fisher WE, 2001, WORLD J SURG, V25, P503, DOI 10.1007/s002680020344
   Foster KG, 2010, J BIOL CHEM, V285, P14071, DOI 10.1074/jbc.R109.094003
   Freed-Pastor WA, 2012, CELL, V148, P244, DOI 10.1016/j.cell.2011.12.017
   Funahashi H, 2007, CANCER RES, V67, P7068, DOI 10.1158/0008-5472.CAN-07-0970
   Garami A, 2003, MOL CELL, V11, P1457, DOI 10.1016/S1097-2765(03)00220-X
   Gavi S, 2006, TRENDS ENDOCRIN MET, V17, P46, DOI 10.1016/j.tem.2006.01.006
   Gong J, 2014, FRONT PHYSIOL, V5, DOI 10.3389/fphys.2014.00426
   Goodwin PJ, 2015, ANNU REV MED, V66, P281, DOI 10.1146/annurev-med-051613-012328
   Goodwin PJ, 2008, CLIN BREAST CANCER, V8, P501, DOI 10.3816/CBC.2008.n.060
   Gruber R, 2016, GASTROENTEROLOGY, V151, P526, DOI 10.1053/j.gastro.2016.05.006
   Guerra C, 2007, CANCER CELL, V11, P291, DOI 10.1016/j.ccr.2007.01.012
   Guha S, 2005, CANCER RES, V65, P2738, DOI 10.1158/0008-5472.CAN-04-3197
   Guha S, 2003, CANCER RES, V63, P2379
   Guha S, 2002, CANCER RES, V62, P1632
   Gutkind JS, 1998, ONCOGENE, V17, P1331, DOI 10.1038/sj.onc.1202186
   Gwinn DM, 2008, MOL CELL, V30, P214, DOI 10.1016/j.molcel.2008.03.003
   Haffner SM, 2006, AM J MED, V119, p3S, DOI 10.1016/j.amjmed.2006.01.008
   Hansel DE, 2003, ANNU REV GENOM HUM G, V4, P237, DOI 10.1146/annurev.genom.4.070802.110341
   Hansen CG, 2015, CELL RES, V25, P1299, DOI 10.1038/cr.2015.140
   Hao F, 2017, MOL CANCER RES, V15, P929, DOI 10.1158/1541-7786.MCR-17-0023
   Haque I, 2012, J BIOL CHEM, V287, P38569, DOI 10.1074/jbc.M112.389064
   Harikumar KB, 2010, MOL CANCER THER, V9, P1136, DOI 10.1158/1535-7163.MCT-09-1145
   Hart PA, 2016, LANCET GASTROENTEROL, V1, P226, DOI 10.1016/S2468-1253(16)30106-6
   Harvey AE, 2014, PLOS ONE, V9, DOI [10.1371/journal.pone.0094151, 10.1371/journal.pone.0101803]
   Hawley SA, 2010, CELL METAB, V11, P554, DOI 10.1016/j.cmet.2010.04.001
   Heasley LE, 2001, ONCOGENE, V20, P1563, DOI 10.1038/sj.onc.1204183
   Hertzer KM, 2016, PANCREAS, V45, P458, DOI 10.1097/MPA.0000000000000497
   Hezel AF, 2008, ONCOGENE, V27, P6908, DOI 10.1038/onc.2008.342
   Hingorani SR, 2003, CANCER CELL, V4, P437, DOI 10.1016/S1535-6108(03)00309-X
   Hingorani SR, 2005, CANCER CELL, V7, P469, DOI 10.1016/j.ccr.2005.04.023
   Hirata M, 1999, INT J ONCOL, V14, P1129
   Hong X, 2014, EMBO J, V33, P2447, DOI 10.15252/embj.201489385
   Horiuchi M, 2006, ENDOCR J, V53, P1, DOI 10.1507/endocrj.53.1
   Hruban RH, 2001, AM J SURG PATHOL, V25, P579, DOI 10.1097/00000478-200105000-00003
   Hruban RH, 2006, CANCER RES, V66, P95, DOI 10.1158/0008-5472.CAN-05-2168
   Hruban RH, 2000, CLIN CANCER RES, V6, P2969
   Huang HZ, 2013, PLOS ONE, V8, DOI [10.1371/journal.pone.0059482, 10.1371/journal.pone.0076982, 10.1371/journal.pone.0071808]
   Inoki K, 2006, TRENDS CELL BIOL, V16, P206, DOI 10.1016/j.tcb.2006.02.002
   Inoki K, 2003, CELL, V115, P577, DOI 10.1016/S0092-8674(03)00929-2
   Inoki K, 2006, CELL, V126, P955, DOI 10.1016/j.cell.2006.06.055
   Istvan ES, 2001, SCIENCE, V292, P1160, DOI 10.1126/science.1059344
   Jang WI, 2017, ONCOTARGET, V8, P9587, DOI 10.18632/oncotarget.14525
   Jemal A, 2010, CA-CANCER J CLIN, V60, P277, DOI [10.3322/caac.20073, 10.3322/caac.21551, 10.3322/caac.21654]
   Jeon CY, 2015, PLOS ONE, V10, DOI DOI 10.1371/JOURNAL.PONE.0121783
   Jian-Yu E, 2017, CANCER EPIDEM BIOMAR, V26, P1225, DOI [10.1158/1055-9965.EPI-17-0227, 10.1158/1055-9965.epi-17-0227]
   Jones S, 2008, SCIENCE, V321, P1801, DOI 10.1126/science.1164368
   Kaaks R, 2014, NAT REV ENDOCRINOL, V10, P644, DOI 10.1038/nrendo.2014.168
   Kahn BB, 2005, CELL METAB, V1, P15, DOI 10.1016/j.cmet.2004.12.003
   Kakoki M, 2006, J CLIN INVEST, V116, P1302, DOI 10.1172/JCI26958
   Kakoki M, 2004, P NATL ACAD SCI USA, V101, P13302, DOI 10.1073/pnas.0405449101
   Kalender A, 2010, CELL METAB, V11, P390, DOI 10.1016/j.cmet.2010.03.014
   Kan ZY, 2010, NATURE, V466, P869, DOI 10.1038/nature09208
   Kanda M, 2012, GASTROENTEROLOGY, V142, P730, DOI 10.1053/j.gastro.2011.12.042
   Kant P, 2011, NAT REV GASTRO HEPAT, V8, P224, DOI 10.1038/nrgastro.2011.23
   Kapoor A, 2014, CELL, V158, P185, DOI 10.1016/j.cell.2014.06.003
   Kawasaki D, 2008, CANCER CHEMOTH PHARM, V61, P883, DOI 10.1007/s00280-007-0591-8
   Kensler TW, 2016, CANCER PREV RES, V9, P2, DOI 10.1158/1940-6207.CAPR-15-0406
   Khasawneh J, 2009, P NATL ACAD SCI USA, V106, P3354, DOI 10.1073/pnas.0802864106
   Kim M, 2013, EMBO J, V32, P1543, DOI 10.1038/emboj.2013.102
   Kim NG, 2015, J CELL BIOL, V210, P503, DOI 10.1083/jcb.201501025
   Kisfalvi K, 2005, J CELL PHYSIOL, V202, P880, DOI 10.1002/jcp.20187
   Kisfalvi K, 2007, ENDOCRINOLOGY, V148, P3246, DOI 10.1210/en.2006-1711
   Kisfalvi K, 2013, PANCREAS, V42, P781, DOI 10.1097/MPA.0b013e31827aec40
   Kisfalvi K, 2010, J CELL PHYSIOL, V223, P309, DOI 10.1002/jcp.22036
   Kisfalvi K, 2009, CANCER RES, V69, P6539, DOI 10.1158/0008-5472.CAN-09-0418
   Korner M, 2015, EJNMMI RES, V5, DOI 10.1186/s13550-015-0094-2
   Kopelovich L, 2007, CANCER EPIDEM BIOMAR, V16, P1330, DOI 10.1158/1055-9965.EPI-07-0045
   Kusminski CM, 2016, NAT REV DRUG DISCOV, V15, P639, DOI 10.1038/nrd.2016.75
   Kuzu OF, 2016, CANCER RES, V76, P2063, DOI 10.1158/0008-5472.CAN-15-2613
   Kyrgiou M, 2017, BMJ-BRIT MED J, V356, DOI 10.1136/bmj.j477
   Laplante M, 2009, J CELL SCI, V122, P3589, DOI 10.1242/jcs.051011
   Lashinger LM, 2013, CANCER PREV RES, V6, P1046, DOI 10.1158/1940-6207.CAPR-13-0185
   Lauby-Secretan B, 2016, NEW ENGL J MED, V375, P794, DOI 10.1056/NEJMsr1606602
   Lee HS, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000003607
   Lee JK, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0013437
   Lega IC, 2014, CANCER EPIDEM BIOMAR, V23, P1974, DOI 10.1158/1055-9965.EPI-14-0327
   Li AH, 2011, AM J PATHOL, V178, P1340, DOI 10.1016/j.ajpath.2010.11.058
   Li DH, 2011, CANCER CAUSE CONTROL, V22, P189, DOI 10.1007/s10552-010-9686-3
   Li DH, 2009, GASTROENTEROLOGY, V137, P482, DOI 10.1053/j.gastro.2009.04.013
   Li J, 2016, NATURE, V533, P411, DOI 10.1038/nature17662
   Li XG, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-06207-x
   Liang N, 2014, J EXP MED, V211, P2249, DOI 10.1084/jem.20140341
   Libby G, 2009, DIABETES CARE, V32, P1620, DOI 10.2337/dc08-2175
   Lin LP, 2015, NAT GENET, V47, P250, DOI 10.1038/ng.3218
   Liou GY, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms7200
   Logsdon CD, 2016, INT J BIOL SCI, V12, P338, DOI 10.7150/ijbs.15020
   Loncle C, 2015, CANCER RES, V75, P4852, DOI 10.1158/0008-5472.CAN-15-0896
   Long X, 2004, Curr Top Microbiol Immunol, V279, P115
   Maitra A, 2005, ADV ANAT PATHOL, V12, P81, DOI 10.1097/01.pap.0000155055.14238.25
   Mann DJ, 1997, ONCOGENE, V14, P1759, DOI 10.1038/sj.onc.1201134
   Manning BD, 2002, MOL CELL, V10, P151, DOI 10.1016/S1097-2765(02)00568-3
   McAllister F, 2014, ONCOTARGET, V5, P9530, DOI 10.18632/oncotarget.2618
   Meng ZP, 2016, GENE DEV, V30, P1, DOI 10.1101/gad.274027.115
   Miller MS, 2016, PANCREAS, V45, P1080, DOI 10.1097/MPA.0000000000000705
   Ming M, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0114573
   Mishra AK, 2016, METABOLISM, V65, P48, DOI 10.1016/j.metabol.2015.10.008
   Mo JS, 2015, NAT CELL BIOL, V17, P500, DOI 10.1038/ncb3111
   Moroishi T, 2015, NAT REV CANCER, V15, P73, DOI 10.1038/nrc3876
   Mukhtar H., 2016, JNCI-J NATL CANCER I, P2016
   Neesse A, 2013, P NATL ACAD SCI USA, V110, P12325, DOI 10.1073/pnas.1300415110
   Ning JY, 2010, MOL ENDOCRINOL, V24, P1218, DOI 10.1210/me.2009-0474
   Nowell CS, 2016, NAT CELL BIOL, V18, P168, DOI 10.1038/ncb3290
   Ochi N, 2011, J CELL PHYSIOL, V226, P1074, DOI 10.1002/jcp.22421
   Olive KP, 2009, SCIENCE, V324, P1457, DOI 10.1126/science.1171362
   OMKUMAR RV, 1994, J BIOL CHEM, V269, P6810
   Owen MR, 2000, BIOCHEM J, V348, P607, DOI 10.1042/0264-6021:3480607
   Parekh PJ, 2015, CLIN TRANSL GASTROEN, V6, DOI 10.1038/ctg.2015.16
   Park J, 2014, NAT REV ENDOCRINOL, V10, P455, DOI 10.1038/nrendo.2014.94
   Park YY, 2016, HEPATOLOGY, V63, P159, DOI 10.1002/hep.28223
   Pham NA, 2008, BMC CANCER, V8, DOI 10.1186/1471-2407-8-43
   Philip B, 2013, GASTROENTEROLOGY, V145, P1449, DOI 10.1053/j.gastro.2013.08.018
   Preziosi G, 2014, SURG ONCOL, V23, P61, DOI 10.1016/j.suronc.2014.02.003
   Pylayeva-Gupta Y, 2011, NAT REV CANCER, V11, P761, DOI 10.1038/nrc3106
   QIN YF, 1994, CANCER RES, V54, P1035
   Rahib L, 2014, CANCER RES, V74, P2913, DOI 10.1158/0008-5472.CAN-14-0155
   Renehan AG, 2015, NAT REV CANCER, V15, P484, DOI 10.1038/nrc3967
   Reubi JC, 1998, GUT, V42, P546, DOI 10.1136/gut.42.4.546
   Rey O, 2003, J BIOL CHEM, V278, P23773, DOI 10.1074/jbc.M300226200
   Rey O, 2003, BIOCHEM BIOPH RES CO, V302, P817, DOI 10.1016/S0006-291X(03)00269-9
   Rogers CJ, 2014, CANCER J, V20, P176, DOI 10.1097/PPO.0000000000000049
   ROZENGURT E, 1979, P NATL ACAD SCI USA, V76, P1284, DOI 10.1073/pnas.76.3.1284
   Rozengurt E, 2002, TRENDS ENDOCRIN MET, V13, P128, DOI 10.1016/S1043-2760(01)00544-6
   Rozengurt E, 2005, J BIOL CHEM, V280, P13205, DOI 10.1074/jbc.R500002200
   ROZENGURT E, 1983, P NATL ACAD SCI-BIOL, V80, P2936, DOI 10.1073/pnas.80.10.2936
   Rozengurt E, 2001, ANNU REV PHYSIOL, V63, P49, DOI 10.1146/annurev.physiol.63.1.49
   Rozengurt E, 1998, J CELL PHYSIOL, V177, P507, DOI 10.1002/(SICI)1097-4652(199812)177:4<507::AID-JCP2>3.3.CO;2-B
   ROZENGURT E, 1986, SCIENCE, V234, P161, DOI 10.1126/science.3018928
   ROZENGURT E, 1992, Current Opinion in Cell Biology, V4, P161, DOI 10.1016/0955-0674(92)90027-A
   Rozengurt E., 2014, FRONT PHYSIOL, P2014
   Rozengurt Enrique, 1999, Current Opinion in Oncology, V11, P116
   Rozengurt E, 2007, J CELL PHYSIOL, V213, P589, DOI 10.1002/jcp.21246
   Rozengurt E, 2014, MOL CANCER THER, V13, P2477, DOI 10.1158/1535-7163.MCT-14-0330
   Rozengurt E, 2011, PHYSIOLOGY, V26, P23, DOI 10.1152/physiol.00037.2010
   Rozengurt E, 2010, CLIN CANCER RES, V16, P2505, DOI 10.1158/1078-0432.CCR-09-2229
   Ryder NM, 2001, J CELL PHYSIOL, V186, P53, DOI 10.1002/1097-4652(200101)186:1<53::AID-JCP1004>3.0.CO;2-Q
   Sadeghi N, 2012, CLIN CANCER RES, V18, P2905, DOI 10.1158/1078-0432.CCR-11-2994
   Sah RP, 2013, NAT REV GASTRO HEPAT, V10, P423, DOI 10.1038/nrgastro.2013.49
   Allende MTS, 2017, PANCREAS, V46, P913, DOI 10.1097/MPA.0000000000000867
   Santinon G, 2016, TRENDS CELL BIOL, V26, P289, DOI 10.1016/j.tcb.2015.11.004
   Schulz MD, 2014, NATURE, V514, P508, DOI 10.1038/nature13398
   Schwenk RW, 2013, MOL METAB, V2, P337, DOI 10.1016/j.molmet.2013.09.002
   Seckl MJ, 1997, CANCER RES, V57, P51
   Seufferlein T, 1999, GASTROENTEROLOGY, V116, P1441, DOI 10.1016/S0016-5085(99)70509-3
   Seufferlein T, 1996, J BIOL CHEM, V271, P21471, DOI 10.1074/jbc.271.35.21471
   Shaw RJ, 2005, SCIENCE, V310, P1642, DOI 10.1126/science.1120781
   Shaw RJ, 2004, CANCER CELL, V6, P91, DOI 10.1016/j.ccr.2004.06.007
   Singh R. G., 2017, CLIN EXP MED
   Sinnett-Smith J, 2000, J BIOL CHEM, V275, P30644, DOI 10.1074/jbc.M003702200
   Sinnett-Smith J, 2004, J BIOL CHEM, V279, P16883, DOI 10.1074/jbc.M313225200
   Sinnett-Smith J, 2013, BIOCHEM BIOPH RES CO, V430, P352, DOI 10.1016/j.bbrc.2012.11.010
   Sinnett-Smith J, 2009, J BIOL CHEM, V284, P13434, DOI 10.1074/jbc.M806554200
   SMIT VTHBM, 1988, NUCLEIC ACIDS RES, V16, P7773, DOI 10.1093/nar/16.16.7773
   Smith JP, 2004, REGUL PEPTIDES, V117, P167, DOI 10.1016/j.regpep.2003.10.013
   Soares HP, 2015, MOL CANCER THER, V14, P1014, DOI 10.1158/1535-7163.MCT-14-0669
   Soares HP, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0057289
   Song MS, 2012, NAT REV MOL CELL BIO, V13, P283, DOI 10.1038/nrm3330
   Sorrentino G, 2014, NAT CELL BIOL, V16, P357, DOI 10.1038/ncb2936
   Sowers JR, 2004, AM J PHYSIOL-HEART C, V286, pH1597, DOI 10.1152/ajpheart.00026.2004
   Strassburger K, 2012, DEV BIOL, V367, P187, DOI 10.1016/j.ydbio.2012.05.008
   Strnadel J, 2017, CANCER RES, V77, P1997, DOI 10.1158/0008-5472.CAN-16-2594
   Suissa S, 2014, DIABETES CARE, V37, P1786, DOI 10.2337/dc14-0500
   Sumara G, 2009, CELL, V136, P235, DOI 10.1016/j.cell.2008.11.018
   Sun K, 2011, J CLIN INVEST, V121, P2094, DOI 10.1172/JCI45887
   Swidnicka-Siergiejko AK, 2017, ONCOGENE, V36, P3149, DOI 10.1038/onc.2016.461
   Sze M. A., 2016, MBIO, P2016
   Tan JX, 2017, ONCOL LETT, V13, P1247, DOI 10.3892/ol.2017.5586
   Taniguchi CM, 2006, NAT REV MOL CELL BIO, V7, P85, DOI 10.1038/nrm1837
   Tanti JF, 2009, CURR OPIN PHARMACOL, V9, P753, DOI 10.1016/j.coph.2009.07.004
   Tee AR, 2002, P NATL ACAD SCI USA, V99, P13571, DOI 10.1073/pnas.202476899
   Tsujimoto T, 2017, INT J CANCER, V141, P102, DOI 10.1002/ijc.30729
   Tumaneng K, 2012, NAT CELL BIOL, V14, P1322, DOI 10.1038/ncb2615
   Tzatsos A, 2007, J BIOL CHEM, V282, P18069, DOI 10.1074/jbc.M610101200
   Uhlen M, 2017, SCIENCE, V357, P660, DOI 10.1126/science.aan2507
   Um SH, 2006, CELL METAB, V3, P393, DOI 10.1016/j.cmet.2006.05.003
   Umar A, 2012, NAT REV CANCER, V12, P835, DOI 10.1038/nrc3397
   Vallejo A, 2017, NAT COMMUN, V8, DOI 10.1038/ncomms14294
   Velloso LA, 2006, DIABETES-METAB RES, V22, P98, DOI 10.1002/dmrr.611
   Walker EJ, 2015, CANCER-AM CANCER SOC, V121, P1287, DOI 10.1002/cncr.29256
   Wang J, 2016, J BIOL CHEM, V291, P17988, DOI 10.1074/jbc.M115.711275
   Wang L, 2000, CLIN CANCER RES, V6, P566
   Wang WQ, 2015, NAT CELL BIOL, V17, P490, DOI 10.1038/ncb3113
   Wang Z, 2014, DIABETES RES CLIN PR, V106, P19, DOI 10.1016/j.diabres.2014.04.007
   Wang ZY, 2014, P NATL ACAD SCI USA, V111, pE89, DOI 10.1073/pnas.1319190110
   Withers DJ, 1997, J BIOL CHEM, V272, P2509
   Witters LA, 2001, J CLIN INVEST, V108, P1105, DOI 10.1172/JCI14178
   Wu BU, 2015, AM J GASTROENTEROL, V110, P1233, DOI 10.1038/ajg.2015.217
   Wullschleger S, 2006, CELL, V124, P471, DOI 10.1016/j.cell.2006.01.016
   Xiao AY, 2016, LANCET GASTROENTEROL, V1, P45, DOI 10.1016/S2468-1253(16)30004-8
   Xie DC, 2015, ONCOTARGET, V6, P35949, DOI 10.18632/oncotarget.5772
   Yang SP, 2015, ONCOTARGET, V6, P36019, DOI 10.18632/oncotarget.5935
   Yang WS, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0027326
   Ying HQ, 2016, GENE DEV, V30, P355, DOI 10.1101/gad.275776.115
   Yoshimoto S, 2013, NATURE, V499, P97, DOI 10.1038/nature12347
   Young SH, 2006, AM J PHYSIOL-CELL PH, V290, pC728, DOI 10.1152/ajpcell.00310.2005
   Yu FX, 2013, GENE DEV, V27, P355, DOI 10.1101/gad.210773.112
   Yuan J, 2008, J CELL BIOCHEM, V103, P648, DOI 10.1002/jcb.21439
   Yuan JZ, 2001, J BIOL CHEM, V276, P38619, DOI 10.1074/jbc.M105530200
   Zanconato F, 2015, NAT CELL BIOL, V17, P1218, DOI 10.1038/ncb3216
   Zhang WY, 2014, SCI SIGNAL, V7, DOI 10.1126/scisignal.2005049
   Zhang Y, 2003, NAT CELL BIOL, V5, P578, DOI 10.1038/ncb999
   Zhukova E, 2001, J BIOL CHEM, V276, P40298, DOI 10.1074/jbc.M106512200
NR 256
TC 40
Z9 45
U1 2
U2 28
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1044-579X
EI 1096-3650
J9 SEMIN CANCER BIOL
JI Semin. Cancer Biol.
PD FEB
PY 2019
VL 54
BP 50
EP 62
DI 10.1016/j.semcancer.2017.10.007
PG 13
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA HQ4ZS
UT WOS:000462420400006
PM 29079305
OA Green Accepted
DA 2023-06-08
ER

PT S
AU Deng, SY
   Zhou, XL
   Xu, J
AF Deng, Shouyan
   Zhou, Xiaolin
   Xu, Jie
BE Xu, J
TI Checkpoints Under Traffic Control: From and to Organelles
SO REGULATION OF CANCER IMMUNE CHECKPOINTS: MOLECULAR AND CELLULAR
   MECHANISMS AND THERAPY
SE Advances in Experimental Medicine and Biology
LA English
DT Article; Book Chapter
DE Immune checkpoints; TMD proteins; Trafficking; Exosomal PD-L1;
   Combinatorial immunotherapy
ID GROWTH-FACTOR RECEPTOR; T-CELL-ACTIVATION; IG-LIKE RECEPTORS; GUT
   MICROBIOTA; INTRACELLULAR TRAFFICKING; EXTRACELLULAR VESICLES; TUMOR
   MICROENVIRONMENT; MEMBRANE TRAFFICKING; ANTITUMOR IMMUNITY; SURFACE
   EXPRESSION
AB Immune checkpoints are variegated stimulatory and inhibitory signals that are fundamental in immune homeostasis. The regulative molecules for immune checkpoints include programmed cell death protein 1 (PD1), programmed death-ligand 1 or 2 (PD-L1 or PD-L2), cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), and so on. While the immune checkpoint molecules have gained soaring attention in recent years, the trafficking of them has been rarely studied. Since all of the discovered immune checkpoint molecules are transmembrane domain (TMD) proteins, they share similar pathophysiological characteristics which make studies about their trafficking and associated disorders resembled. PD-L1 is one of the most classic immune checkpoint molecules, and anti-PD1 monoantibodies have shown promising immunotherapeutic effects. PD-L1 trafficking has been particularly studied, the key regulators of which include metformin, chemokine-like factor-like MARVEL transmembrane domain-containing family member (CMTM), Huntingtin-interacting protein 1-related (HIP1R), exosomes, ALIX, polyI:C, and various post-translational modifications. Here, we focus on the checkpoints under traffic control, counting PD-L1, CTLA-4, lymphocyte-activation gene 3 (LAG-3), killer immunoglobulin-like receptors (KIRs), CD70, CD94, and attempt to shed light on the potentials of drug targets based on these findings and look forward to further studies in combinatorial therapeutic regimens in the meantime.
C1 [Deng, Shouyan] Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Shanghai, Peoples R China.
   [Zhou, Xiaolin] Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Sch Med, Dept Neurol, Shanghai 200080, Peoples R China.
   [Xu, Jie] Fudan Univ, Zhongshan Xuhui Hosp, Inst Biomed Sci, Shanghai 200032, Peoples R China.
C3 Shanghai Jiao Tong University; Shanghai Jiao Tong University; Fudan
   University
RP Deng, SY (通讯作者)，Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Shanghai, Peoples R China.
EM 19960528@sjtu.edu.cn; jie_xu@fudan.edu.cn
RI Xu, Jie/K-3712-2019
OI Xu, Jie/0000-0001-9163-3898
CR Abd Elmageed ZY, 2014, STEM CELLS, V32, P983, DOI 10.1002/stem.1619
   Aditi V, 2016, PLOS ONE, V11
   Akbay EA, 2013, CANCER DISCOV, V3, P1355, DOI 10.1158/2159-8290.CD-13-0310
   Anjos S, 2002, J BIOL CHEM, V277, P46478, DOI 10.1074/jbc.M206894200
   [Anonymous], ASCO M, DOI DOI 10.1200/JCO.2013.54.6911
   Azuma K, 2014, ANN ONCOL, V25, P1935, DOI 10.1093/annonc/mdu242
   Bae J, 2014, J IMMUNOL, V193, P3101, DOI 10.4049/jimmunol.1401025
   Bauer PO, 2010, NAT BIOTECHNOL, V28, P256, DOI 10.1038/nbt.1608
   Becart S, 2009, IMMUNOL REV, V232, P319, DOI 10.1111/j.1600-065X.2009.00839.x
   Becker A, 2016, CANCER CELL, V30, P836, DOI 10.1016/j.ccell.2016.10.009
   Biassoni R, 1997, EUR J IMMUNOL, V27, P3095, DOI 10.1002/eji.1830271203
   Bissig C, 2014, TRENDS CELL BIOL, V24, P19, DOI 10.1016/j.tcb.2013.10.009
   Bobrie A, 2012, CANCER RES, V72, P4920, DOI 10.1158/0008-5472.CAN-12-0925
   Boes M, 2015, CANCER LETT, V361, P49, DOI 10.1016/j.canlet.2015.02.027
   Bondeson DP, 2015, NAT CHEM BIOL, V11, P611, DOI [10.1038/NCHEMBIO.1858, 10.1038/nchembio.1858]
   Borel AC, 1996, CELL, V85, P379, DOI 10.1016/S0092-8674(00)81116-2
   Borrego F, 2006, IMMUNOL RES, V35, P263, DOI 10.1385/IR:35:3:263
   Boyce A.M., 1993, GENEREVIEWS
   Breitling J, 2013, CSH PERSPECT BIOL, V5, DOI 10.1101/cshperspect.a013359
   Bunnett NW, 2010, CNS NEUROL DISORD-DR, V9, P539
   Burgess SJ, 2006, J IMMUNOL, V176, P1490, DOI 10.4049/jimmunol.176.3.1490
   Burr ML, 2017, NATURE, V549, P101, DOI 10.1038/nature23643
   CAPORASO GL, 1994, J NEUROSCI, V14, P3122
   Carlton J, 2010, BIOCHEM SOC T, V38, P1397, DOI 10.1042/BST0381397
   Caskey M, 2011, J EXP MED, V208, P2357, DOI 10.1084/jem.20111171
   Cha JH, 2018, MOL CELL, V71, P606, DOI 10.1016/j.molcel.2018.07.030
   CHANG CH, 1995, J EXP MED, V181, P765, DOI 10.1084/jem.181.2.765
   Che TF, 2015, ONCOTARGET, V6, P37349, DOI 10.18632/oncotarget.5736
   Chen G, 2018, NATURE, V560, P382, DOI 10.1038/s41586-018-0392-8
   Chewning JH, 2007, J IMMUNOL, V179, P854, DOI 10.4049/jimmunol.179.2.854
   Chuang E, 1997, J IMMUNOL, V159, P144
   Chwae YJ, 2008, IMMUNOL CELL BIOL, V86, P372, DOI 10.1038/icb.2008.5
   Chwae YJ, 2007, IMMUNOL CELL BIOL, V85, P220, DOI 10.1038/sj.icb.7100031
   Cobbold C, 2003, TRENDS CELL BIOL, V13, P639, DOI 10.1016/j.tcb.2003.10.008
   Cocucci E, 2009, TRENDS CELL BIOL, V19, P43, DOI 10.1016/j.tcb.2008.11.003
   Colonna M, 2000, IMMUNOL TODAY, V21, P428, DOI 10.1016/S0167-5699(00)01697-2
   Corrado C, 2013, INT J MOL SCI, V14, P5338, DOI 10.3390/ijms14035338
   Dal Bello MG, 2017, DRUG DISCOV TODAY, V22, P1266, DOI 10.1016/j.drudis.2017.05.016
   Danzer KM, 2012, MOL NEURODEGENER, V7, DOI 10.1186/1750-1326-7-42
   Daud AI, 2014, AACR ANN M CT104
   Dauer W, 2003, NEURON, V39, P889, DOI 10.1016/S0896-6273(03)00568-3
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   de Rham C, 2007, ARTHRITIS RES THER, V9, DOI 10.1186/ar2336
   Ding L, 2015, ONCOTARGET, V6, P36441, DOI 10.18632/oncotarget.5541
   Eden ER, 2012, TRAFFIC, V13, P329, DOI 10.1111/j.1600-0854.2011.01305.x
   Eikawa S, 2015, P NATL ACAD SCI USA, V112, P1809, DOI 10.1073/pnas.1417636112
   Emanueli C, 2015, VASC PHARMACOL, V71, P24, DOI 10.1016/j.vph.2015.02.008
   Evans JMM, 2005, BMJ-BRIT MED J, V330, P1304, DOI 10.1136/bmj.38415.708634.F7
   Fan XL, 2014, NAT NEUROSCI, V17, P471, DOI 10.1038/nn.3637
   Feng YH, 2010, CANCER SCI, V101, P2033, DOI 10.1111/j.1349-7006.2010.01637.x
   Ferris SP, 2014, DIS MODEL MECH, V7, P331, DOI 10.1242/dmm.014589
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Frame S, 2001, BIOCHEM J, V359, P1, DOI 10.1042/0264-6021:3590001
   Freeman GJ, 2000, J EXP MED, V192, P1027, DOI 10.1084/jem.192.7.1027
   Friedl P, 2005, NAT REV IMMUNOL, V5, P532, DOI 10.1038/nri1647
   Gandhi L, 2014, AACR ANN M CT105
   Gargalionis AN, 2014, INT J CANCER, V134, P2019, DOI 10.1002/ijc.28299
   GOODWIN RG, 1993, CELL, V73, P447, DOI 10.1016/0092-8674(93)90133-B
   Gottfried I, 2010, BIOCHEM SOC T, V38, P187, DOI 10.1042/BST0380187
   Greenberg M, 1998, CURR BIOL, V8, P1239, DOI 10.1016/S0960-9822(07)00518-0
   GUMPERZ JE, 1995, NATURE, V378, P245, DOI 10.1038/378245a0
   Gyorgy B, 2011, CELL MOL LIFE SCI, V68, P2667, DOI 10.1007/s00018-011-0689-3
   Haderk F, 2017, SCI IMMUNOL, V2, DOI 10.1126/sciimmunol.aah5509
   Han WL, 2003, GENOMICS, V81, P609, DOI 10.1016/S0888-7543(03)00095-8
   Hanyaloglu AC, 2008, ANNU REV PHARMACOL, V48, P537, DOI 10.1146/annurev.pharmtox.48.113006.094830
   Henne WM, 2011, DEV CELL, V21, P77, DOI 10.1016/j.devcel.2011.05.015
   Huard B, 1997, P NATL ACAD SCI USA, V94, P5744, DOI 10.1073/pnas.94.11.5744
   HUARD B, 1995, EUR J IMMUNOL, V25, P2718, DOI 10.1002/eji.1830250949
   Hurley JH, 2015, EMBO J, V34, P2398, DOI 10.15252/embj.201592484
   Iida T, 2000, J IMMUNOL, V165, P5062, DOI 10.4049/jimmunol.165.9.5062
   Iwai Y, 2002, P NATL ACAD SCI USA, V99, P12293, DOI 10.1073/pnas.192461099
   Jain RN, 2008, J CLIN INVEST, V118, P2459, DOI 10.1172/JCI33569
   Kalra H, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17020170
   Keller AM, 2007, P NATL ACAD SCI USA, V104, P5989, DOI 10.1073/pnas.0700946104
   Khailaie S, 2018, BIOPHYS J, V115, P1330, DOI 10.1016/j.bpj.2018.08.020
   Kunisada Y, 2017, EBIOMEDICINE, V25, P154, DOI 10.1016/j.ebiom.2017.10.009
   Kyriachenko Y, 2019, WORLD J DIABETES, V10, P154, DOI 10.4239/wjd.v10.i3.154
   Kyttala A, 2005, J BIOL CHEM, V280, P10277, DOI 10.1074/jbc.M411862200
   Lanier LL, 1998, ANNU REV IMMUNOL, V16, P359, DOI 10.1146/annurev.immunol.16.1.359
   Latchman Y, 2001, NAT IMMUNOL, V2, P261, DOI 10.1038/85330
   Lee H, 2018, GUT MICROBES, V9, P155, DOI 10.1080/19490976.2017.1405209
   Lemmon MA, 2010, CELL, V141, P1117, DOI 10.1016/j.cell.2010.06.011
   Leroyer AS, 2007, J AM COLL CARDIOL, V49, P772, DOI 10.1016/j.jacc.2006.10.053
   LEUNG HT, 1995, J BIOL CHEM, V270, P25107, DOI 10.1074/jbc.270.42.25107
   Li CW, 2018, CANCER CELL, V33, P187, DOI 10.1016/j.ccell.2018.01.009
   Li CW, 2016, NAT COMMUN, V7, DOI 10.1038/ncomms12632
   Li JH, 2013, NAT IMMUNOL, V14, P793, DOI 10.1038/ni.2647
   Li NY, 2007, EMBO J, V26, P494, DOI 10.1038/sj.emboj.7601520
   Lim SO, 2016, CANCER CELL, V30, P925, DOI 10.1016/j.ccell.2016.10.010
   Linsley PS, 1996, IMMUNITY, V4, P535, DOI 10.1016/S1074-7613(00)80480-X
   Lo B, 2015, SCIENCE, V349, P436, DOI 10.1126/science.aaa1663
   Marchese A, 2001, J BIOL CHEM, V276, P45509, DOI 10.1074/jbc.C100527200
   Masilamani M, 2008, TRAFFIC, V9, P1019, DOI 10.1111/j.1600-0854.2008.00738.x
   Masyuk AI, 2013, J HEPATOL, V59, P621, DOI 10.1016/j.jhep.2013.03.028
   Meacham GC, 2001, NAT CELL BIOL, V3, P100, DOI 10.1038/35050509
   Mead KI, 2005, J IMMUNOL, V174, P4803, DOI 10.4049/jimmunol.174.8.4803
   Mendelsohn J, 2006, SEMIN ONCOL, V33, P369, DOI 10.1053/j.seminoncol.2006.04.003
   Monypenny J, 2018, CELL REP, V24, P630, DOI 10.1016/j.celrep.2018.06.066
   Moretta A, 1996, ANNU REV IMMUNOL, V14, P619, DOI 10.1146/annurev.immunol.14.1.619
   Mulrooney TJ, 2013, J LEUKOCYTE BIOL, V94, P301, DOI 10.1189/jlb.0213093
   Murillo MM, 2014, J CLIN INVEST, V124, P3601, DOI 10.1172/JCI74134
   Nabet B, 2018, NAT CHEM BIOL, V14, P431, DOI 10.1038/s41589-018-0021-8
   Nagato T, 2014, CLIN CANCER RES, V20, P1223, DOI 10.1158/1078-0432.CCR-13-2781
   Oshima H, 1998, INT IMMUNOL, V10, P517, DOI 10.1093/intimm/10.4.517
   Ostrowski M, 2010, NAT CELL BIOL, V12, P19, DOI 10.1038/ncb2000
   Park YP, 2011, BLOOD, V118, P3019, DOI 10.1182/blood-2011-04-346825
   Pereira Felipe V, 2018, Oncotarget, V9, P25808, DOI 10.18632/oncotarget.25380
   Pierre P, 1997, NATURE, V388, P787, DOI 10.1038/42039
   Poggio M, 2019, CELL, V177, P414, DOI 10.1016/j.cell.2019.02.016
   Pollak M, 2017, DIABETOLOGIA, V60, P1662, DOI 10.1007/s00125-017-4352-x
   Pradere JP, 2014, ONCOGENE, V33, P3485, DOI 10.1038/onc.2013.302
   Pulko V, 2009, J IMMUNOL, V183, P3634, DOI 10.4049/jimmunol.0900974
   Raiborg C, 2009, NATURE, V458, P445, DOI 10.1038/nature07961
   Rodig N, 2003, EUR J IMMUNOL, V33, P3117, DOI 10.1002/eji.200324270
   Roepstorff K, 2009, TRAFFIC, V10, P1115, DOI 10.1111/j.1600-0854.2009.00943.x
   Rutishauser J, 2002, SWISS MED WKLY, V132, P211
   Sakamoto KM, 2001, P NATL ACAD SCI USA, V98, P8554, DOI 10.1073/pnas.141230798
   Salmon H, 2016, IMMUNITY, V44, P924, DOI 10.1016/j.immuni.2016.03.012
   Sanni TB, 2004, MOL BIOL CELL, V15, P3210, DOI 10.1091/mbc.E03-11-0779
   Sansom DM, 2015, SCIENCE, V349, P377, DOI 10.1126/science.aac7888
   Sansom DM, 2000, IMMUNOLOGY, V101, P169, DOI 10.1046/j.1365-2567.2000.00121.x
   Schneider H, 1999, J IMMUNOL, V163, P1868
   Serwas NK, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-10812-x
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Shiratori T, 1997, IMMUNITY, V6, P583, DOI 10.1016/S1074-7613(00)80346-5
   Snyder MR, 2004, J IMMUNOL, V173, P3725, DOI 10.4049/jimmunol.173.6.3725
   Snyder MR, 2003, J EXP MED, V197, P437, DOI 10.1084/jem.20020383
   Steffens U, 1998, TISSUE ANTIGENS, V51, P398
   Stewart CA, 2005, P NATL ACAD SCI USA, V102, P13224, DOI 10.1073/pnas.0503594102
   Swanton E, 2003, MOL MEMBR BIOL, V20, P99, DOI 10.1080/0968768031000069241
   Tan XJ, 2016, TRENDS CELL BIOL, V26, P352, DOI 10.1016/j.tcb.2015.12.006
   Tesselaar K, 1997, J IMMUNOL, V159, P4959
   TRIEBEL F, 1990, J EXP MED, V171, P1393, DOI 10.1084/jem.171.5.1393
   Turley SJ, 2000, SCIENCE, V288, P522, DOI 10.1126/science.288.5465.522
   Valk E, 2006, IMMUNITY, V25, P807, DOI 10.1016/j.immuni.2006.08.024
   van der Pol E, 2012, PHARMACOL REV, V64, P676, DOI 10.1124/pr.112.005983
   Verdura S, 2019, ONCOIMMUNOLOGY, V8, DOI 10.1080/2162402X.2019.1633235
   Walsh AM, 2013, J CELL SCI, V126, P4339, DOI 10.1242/jcs.123208
   Wang HB, 2019, NAT CHEM BIOL, V15, P42, DOI 10.1038/s41589-018-0161-x
   Woo SR, 2010, EUR J IMMUNOL, V40, P1768, DOI 10.1002/eji.200939874
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Wubbolts R, 1999, J CELL SCI, V112, P785
   Xu CC, 2015, NAT REV MOL CELL BIO, V16, P742, DOI 10.1038/nrm4073
   Yang Y, 2019, CELL RES, V29, P83, DOI 10.1038/s41422-018-0124-5
   Yang Y, 2018, CELL RES, V28, P862, DOI 10.1038/s41422-018-0060-4
   Yao H, 2019, NAT BIOMED ENG, V3, P306, DOI 10.1038/s41551-019-0375-6
   Zaborowski MP, 2015, BIOSCIENCE, V65, P783, DOI 10.1093/biosci/biv084
   Zhang JF, 2018, NATURE, V553, P91, DOI 10.1038/nature25015
   Zhang XF, 2015, J INEQUAL APPL, DOI 10.1186/1029-242X-2015-1
   Zhang Y, 1997, P NATL ACAD SCI USA, V94, P9273, DOI 10.1073/pnas.94.17.9273
   Zitvogel L, 2016, NAT REV CLIN ONCOL, V13, P431, DOI 10.1038/nrclinonc.2016.41
NR 151
TC 5
Z9 6
U1 0
U2 11
PU SPRINGER INTERNATIONAL PUBLISHING AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 0065-2598
EI 2214-8019
BN 978-981-15-3266-5; 978-981-15-3265-8
J9 ADV EXP MED BIOL
JI Adv.Exp.Med.Biol.
PY 2020
VL 1248
BP 431
EP 453
DI 10.1007/978-981-15-3266-5_18
D2 10.1007/978-981-15-3266-5
PG 23
WC Oncology; Immunology; Medicine, Research & Experimental
WE Book Citation Index– Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Immunology; Research & Experimental Medicine
GA BP4YC
UT WOS:000554918800018
PM 32185721
DA 2023-06-08
ER

PT J
AU Jones, BDM
   Farooqui, S
   Kloiber, S
   Husain, MO
   Mulsant, BH
   Husain, MI
AF Jones, Brett D. M.
   Farooqui, Salman
   Kloiber, Stefan
   Husain, Muhammad Omair
   Mulsant, Benoit H.
   Husain, Muhammad Ishrat
TI Targeting Metabolic Dysfunction for the Treatment of Mood Disorders:
   Review of the Evidence
SO LIFE-BASEL
LA English
DT Review
DE major depressive disorder; bipolar disorder; metabolic function
ID MAJOR DEPRESSIVE DISORDER; PIOGLITAZONE ADJUNCTIVE THERAPY;
   POLYUNSATURATED FATTY-ACIDS; FORCED SWIMMING TEST; DOUBLE-BLIND; BIPOLAR
   DISORDER; PPAR-GAMMA; INTRANASAL INSULIN; CONTROLLED-TRIAL;
   BIDIRECTIONAL ASSOCIATION
AB Major depressive disorder (MDD) and bipolar disorder (BD) are often chronic with many patients not responding to available treatments. As these mood disorders are frequently associated with metabolic dysfunction, there has been increased interest in novel treatments that would target metabolic pathways. The objectives of this scoping review were to synthesize evidence on the impact on mood symptoms of lipid lowering agents and anti-diabetics drugs, while also reviewing current knowledge on the association between mood disorders and dyslipidemia or hyperglycemia. We propose that metabolic dysfunction is prevalent in both MDD and BD and it may contribute to the development of these disorders through a variety of pathophysiological processes including inflammation, brain structural changes, hormonal alterations, neurotransmitter disruptions, alteration on brain cholesterol, central insulin resistance, and changes in gut microbiota. Current evidence is conflicting on the use of statins, polyunsaturated fatty acids, thiazolidinediones, glucagon-like peptide agonists, metformin, or insulin for the treatment of MDD and BD. Given the paucity of high-quality randomized controlled trials, additional studies are needed before any of these medications can be repurposed in routine clinical practice. Future trials need to enrich patient recruitment, include evaluations of mechanism of action, and explore differential effects on specific symptom domains such as anhedonia, suicidality, and cognition.
C1 [Jones, Brett D. M.; Kloiber, Stefan; Husain, Muhammad Omair; Mulsant, Benoit H.; Husain, Muhammad Ishrat] Univ Toronto, Dept Psychiat, Toronto, ON M5T 1R8, Canada.
   [Jones, Brett D. M.; Kloiber, Stefan; Husain, Muhammad Omair; Mulsant, Benoit H.; Husain, Muhammad Ishrat] Ctr Addict & Mental Hlth, Toronto, ON M6J 1H4, Canada.
   [Farooqui, Salman] Univ Ottawa, Dept Biol, Ottawa, ON K1N 6N5, Canada.
C3 University of Toronto; University of Toronto; Centre for Addiction &
   Mental Health - Canada; University of Ottawa
RP Husain, MI (通讯作者)，Univ Toronto, Dept Psychiat, Toronto, ON M5T 1R8, Canada.; Husain, MI (通讯作者)，Ctr Addict & Mental Hlth, Toronto, ON M6J 1H4, Canada.
EM Brett.jones@mail.utoronto.ca; sifarooqui01@gmail.com;
   stefan.kloiber@camh.ca; Omair.Husain@camh.ca;
   Benoit.Mulsant@utoronto.ca; Ishrat.husain@camh.ca
RI Kloiber, Stefan/AAW-8786-2021
OI Kloiber, Stefan/0000-0002-6838-4114; Mulsant,
   Benoit/0000-0002-0303-6450; Jones, Brett/0000-0003-3248-1059
FU Department of Psychiatry, University of Toronto; Labatt Family Chair in
   Biology of Depression in Late-Life Adults at the University of Toronto
FX This work was supported in part by Academic Scholars Awards to M.I.H.
   and S.K. from the Department of Psychiatry, University of Toronto and by
   B.H.M.'s Labatt Family Chair in Biology of Depression in Late-Life
   Adults at the University of Toronto.
CR Abbasi SH, 2015, J AFFECT DISORDERS, V183, P149, DOI 10.1016/j.jad.2015.04.049
   Abdallah MS, 2020, NEUROTHERAPEUTICS, V17, P1897, DOI 10.1007/s13311-020-00878-7
   Abrahamian H, 2009, NEUROPSYCH DIS TREAT, V5, P261
   Aftab A, 2019, J AFFECT DISORDERS, V245, P957, DOI 10.1016/j.jad.2018.11.090
   Ahmed AAE, 2009, BEHAV PHARMACOL, V20, P635, DOI 10.1097/FBP.0b013e328331b9bf
   Albracht-Schulte K, 2018, J NUTR BIOCHEM, V58, P1, DOI 10.1016/j.jnutbio.2018.02.012
   Ali S, 2006, DIABETIC MED, V23, P1165, DOI 10.1111/j.1464-5491.2006.01943.x
   Almeida OP, 2014, MOL PSYCHIATR, V19, P637, DOI 10.1038/mp.2013.113
   American Psychiatric Association, 2022, DIAGNOSTIC STAT MANU, V5th
   Ancelin ML, 2010, BIOL PSYCHIAT, V68, P125, DOI 10.1016/j.biopsych.2010.04.011
   Anderson RJ, 2001, DIABETES CARE, V24, P1069, DOI 10.2337/diacare.24.6.1069
   Benedict C, 2004, PSYCHONEUROENDOCRINO, V29, P1326, DOI 10.1016/j.psyneuen.2004.04.003
   Berk M, 2020, BMC MED, V18, DOI 10.1186/s12916-019-1475-6
   Bot M, 2020, BIOL PSYCHIAT, V87, P409, DOI 10.1016/j.biopsych.2019.08.016
   Bowden CL, 2012, CNS NEUROSCI THER, V18, P243, DOI 10.1111/j.1755-5949.2011.00257.x
   Budni J, 2012, J PSYCHOPHARMACOL, V26, P714, DOI 10.1177/0269881111424456
   Cabou C, 2008, DIABETES, V57, P2577, DOI 10.2337/db08-0121
   Calkin CV, 2013, ANN MED, V45, P171, DOI 10.3109/07853890.2012.687835
   Cha DS, 2017, J AFFECT DISORDERS, V210, P57, DOI 10.1016/j.jad.2016.12.006
   Chen PH, 2021, J AFFECT DISORDERS, V281, P99, DOI 10.1016/j.jad.2020.11.127
   Chien IC, 2013, J PSYCHOSOM RES, V75, P270, DOI 10.1016/j.jpsychores.2013.06.003
   Chien IC, 2010, GEN HOSP PSYCHIAT, V32, P577, DOI 10.1016/j.genhosppsych.2010.09.005
   Chuang CS, 2014, GEN HOSP PSYCHIAT, V36, P497, DOI 10.1016/j.genhosppsych.2014.05.008
   Ciappolino V, 2020, NUTRIENTS, V12, DOI 10.3390/nu12030708
   De Berardis Domenico, 2012, ISRN Psychiatry, V2012, P387901, DOI 10.5402/2012/387901
   De Berardis D, 2008, PROG NEURO-PSYCHOPH, V32, P1982, DOI 10.1016/j.pnpbp.2008.09.022
   De Giorgi R, 2021, PLOS ONE, V16, DOI 10.1371/journal.pone.0249409
   During MJ, 2003, NAT MED, V9, P1173, DOI 10.1038/nm919
   Geraets AFJ, 2020, DIABETOLOGIA, V63, P2315, DOI 10.1007/s00125-020-05247-9
   Gerard C, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00029
   Ghanizadeh Ahmad, 2014, Depress Res Treat, V2014, P730505, DOI 10.1155/2014/730505
   Ghanizadeh A, 2013, DEPRESS ANXIETY, V30, P1084, DOI 10.1002/da.22195
   GOFMAN JW, 1950, SCIENCE, V111, P166, DOI 10.1126/science.111.2877.166
   Golden SH, 2008, JAMA-J AM MED ASSOC, V299, P2751, DOI 10.1001/jama.299.23.2751
   Gougol A, 2015, J PSYCHOPHARMACOL, V29, P575, DOI 10.1177/0269881115578160
   Guo M, 2014, CLIN EXP PHARMACOL P, V41, P650, DOI 10.1111/1440-1681.12265
   Haghighi M, 2014, J PSYCHIATR RES, V58, P109, DOI 10.1016/j.jpsychires.2014.07.018
   Hibbeln JR, 1998, LANCET, V351, P1213, DOI 10.1016/S0140-6736(05)79168-6
   Hirayama T, 1990, CONTRIB EPIDEMIOL BI
   Holt RIG, 2014, CURR DIABETES REP, V14, DOI 10.1007/s11892-014-0491-3
   Hsu JH, 2015, GEN HOSP PSYCHIAT, V37, P294, DOI 10.1016/j.genhosppsych.2015.04.003
   Jones BDM, 2020, BJPSYCH OPEN, V6, DOI 10.1192/bjo.2020.43
   Kaiser CC, 2009, J NEUROIMMUNOL, V211, P124, DOI 10.1016/j.jneuroim.2009.04.011
   Kashani L, 2013, PSYCHONEUROENDOCRINO, V38, P767, DOI 10.1016/j.psyneuen.2012.08.010
   Kemp DE, 2014, CNS DRUGS, V28, P571, DOI 10.1007/s40263-014-0158-2
   Kemp DE, 2012, J AFFECT DISORDERS, V136, P1164, DOI 10.1016/j.jad.2011.06.033
   Kim SW, 2015, TRANSL PSYCHIAT, V5, DOI 10.1038/tp.2015.116
   Kodas E, 2002, NEUROSCI LETT, V321, P95, DOI 10.1016/S0304-3940(01)02481-8
   Liao YH, 2019, TRANSL PSYCHIAT, V9, DOI 10.1038/s41398-019-0515-5
   Lin KW, 2015, PSYCHIAT RES, V230, P846, DOI 10.1016/j.psychres.2015.10.013
   Lin PY, 2010, BIOL PSYCHIAT, V68, P140, DOI 10.1016/j.biopsych.2010.03.018
   Lotfi M, 2016, RECENT PATENTS INFLA, V10, P133, DOI 10.2174/1872213X10666161028153258
   Luo XD, 2020, BMC PSYCHIATRY, V20, DOI 10.1186/s12888-020-02656-3
   Silva NDLE, 2019, FRONT PSYCHIATRY, V10, DOI 10.3389/fpsyt.2019.00057
   Mansur RB, 2017, J AFFECT DISORDERS, V207, P114, DOI 10.1016/j.jad.2016.09.056
   Marijnissen RM, 2017, PSYCHOL MED, V47, P1041, DOI 10.1017/S0033291716003196
   McClean PL, 2010, EUR J PHARMACOL, V630, P158, DOI 10.1016/j.ejphar.2009.12.023
   McIntyre RS, 2012, BIPOLAR DISORD, V14, P697, DOI 10.1111/bdi.12006
   McNamara RK, 2016, BIPOLAR DISORD, V18, P300, DOI 10.1111/bdi.12386
   McNamara RK, 2010, PROSTAG LEUKOTR ESS, V83, P185, DOI 10.1016/j.plefa.2010.08.004
   McPhilemy G, 2021, BIPOLAR DISORD, V23, P697, DOI 10.1111/bdi.13037
   Messamore E, 2017, PROG LIPID RES, V66, P1, DOI 10.1016/j.plipres.2017.01.001
   Miller BW, 2011, ANN PHARMACOTHER, V45, P1416, DOI 10.1345/aph.1Q238
   Muller CP, 2015, BBA-MOL CELL BIOL L, V1851, P1052, DOI 10.1016/j.bbalip.2014.12.014
   Noaghiul S, 2003, AM J PSYCHIAT, V160, P2222, DOI 10.1176/appi.ajp.160.12.2222
   Owens SD, 1999, J NUTR, V129, P2088, DOI 10.1093/jn/129.11.2088
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Parekh A, 2017, HEALTHCARE-BASEL, V5, DOI 10.3390/healthcare5010005
   Partonen T, 1999, BRIT J PSYCHIAT, V175, P259, DOI 10.1192/bjp.175.3.259
   Penninx B.W, 2021, ACTA PSYCHIAT SCAND, DOI [10.1016/j.euroneuro.2020.09.531, DOI 10.1111/acps.13310]
   Persons JE, 2016, J AFFECT DISORDERS, V206, P55, DOI 10.1016/j.jad.2016.07.033
   Rapaport MH, 2016, MOL PSYCHIATR, V21, P71, DOI 10.1038/mp.2015.22
   Rasgon NL, 2010, THESCIENTIFICWORLDJO, V10, P321, DOI 10.1100/tsw.2010.32
   Rosa AO, 2008, PROG NEURO-PSYCHOPH, V32, P1549, DOI 10.1016/j.pnpbp.2008.05.020
   Ruscica M, 2018, ANN MED, V50, P461, DOI 10.1080/07853890.2018.1498118
   Rush AJ, 2006, AM J PSYCHIAT, V163, P1905, DOI 10.1176/appi.ajp.163.11.1905
   Sadaghiani MS, 2011, BEHAV BRAIN RES, V224, P336, DOI 10.1016/j.bbr.2011.06.011
   Salvucci E, 2019, INT J FOOD SCI NUTR, V70, P781, DOI 10.1080/09637486.2019.1580682
   Saunders EFH, 2016, J CLIN PSYCHIAT, V77, pE1301, DOI 10.4088/JCP.15r09925
   Sepanjnia K, 2012, NEUROPSYCHOPHARMACOL, V37, P2093, DOI 10.1038/npp.2012.58
   Shanmugam N, 2003, DIABETES, V52, P1256, DOI 10.2337/diabetes.52.5.1256
   Shin JY, 2008, ANN BEHAV MED, V36, P33, DOI 10.1007/s12160-008-9045-8
   Soh JF, 2020, J AFFECT DISORDERS, V262, P149, DOI 10.1016/j.jad.2019.11.013
   Spiegelman BM, 1998, DIABETES, V47, P507, DOI 10.2337/diabetes.47.4.507
   Tanskanen A, 2001, PSYCHIATR SERV, V52, P529, DOI 10.1176/appi.ps.52.4.529
   Vancampfort D, 2015, DEPRESS ANXIETY, V32, P763, DOI 10.1002/da.22387
   Vancampfort D, 2013, AM J PSYCHIAT, V170, P265, DOI 10.1176/appi.ajp.2012.12050620
   Vogelzangs N, 2014, NEUROPSYCHOPHARMACOL, V39, P1624, DOI 10.1038/npp.2014.9
   Vogelzangs N, 2011, J CLIN PSYCHIAT, V72, P598, DOI 10.4088/JCP.10m06559
   Wandell P, 2014, J PSYCHOSOM RES, V77, P169, DOI 10.1016/j.jpsychores.2014.06.012
   Winter G, 2018, REV NEUROSCIENCE, V29, P629, DOI 10.1515/revneuro-2017-0072
   World Health Organization, 2008, WHO GLOB BURD DIS
   World Health Organization, 2019, INT STAT CLASS DIS R, DOI DOI 10/2019/EN(2019
   Wulsin LR, 1999, PSYCHOSOM MED, V61, P6, DOI 10.1097/00006842-199901000-00003
   Zeinoddini A, 2015, DEPRESS ANXIETY, V32, P167, DOI 10.1002/da.22340
   Zhou J, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19102863
   Zimmer L, 2000, NEUROSCI LETT, V284, P25, DOI 10.1016/S0304-3940(00)00950-2
   Zimmer L, 1998, NEUROSCI LETT, V240, P177, DOI 10.1016/S0304-3940(97)00938-5
NR 98
TC 10
Z9 10
U1 5
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2075-1729
J9 LIFE-BASEL
JI Life-Basel
PD AUG
PY 2021
VL 11
IS 8
AR 819
DI 10.3390/life11080819
PG 19
WC Biology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Life Sciences & Biomedicine - Other Topics; Microbiology
GA UG9MT
UT WOS:000689567600001
PM 34440563
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Beger, RD
   Schmidt, MA
   Kaddurah-Daouk, R
AF Beger, Richard D.
   Schmidt, Michael A.
   Kaddurah-Daouk, Rima
TI Current Concepts in Pharmacometabolomics, Biomarker Discovery, and
   Precision Medicine
SO METABOLITES
LA English
DT Review
DE pharmacometabolomics; pharmacometabonomics; precision medicine; drug
   response; metabotypes
ID GUT MICROBIOTA; DRUG RESPONSE; METFORMIN USE; PHARMACOGENOMICS;
   VARIABILITY; METABOLOMICS; TOXICITY; THERAPY; ASSOCIATION; DEFICIENCY
AB Pharmacometabolomics (PMx) studies use information contained in metabolic profiles (or metabolome) to inform about how a subject will respond to drug treatment. Genome, gut microbiome, sex, nutrition, age, stress, health status, and other factors can impact the metabolic profile of an individual. Some of these factors are known to influence the individual response to pharmaceutical compounds. An individual's metabolic profile has been referred to as his or her "metabotype." As such, metabolomic profiles obtained prior to, during, or after drug treatment could provide insights about drug mechanism of action and variation of response to treatment. Furthermore, there are several types of PMx studies that are used to discover and inform patterns associated with varied drug responses (i.e., responders vs. non-responders; slow or fast metabolizers). The PMx efforts could simultaneously provide information related to an individual's pharmacokinetic response during clinical trials and be used to predict patient response to drugs making pharmacometabolomic clinical research valuable for precision medicine. PMx biomarkers can also be discovered and validated during FDA clinical trials. Using biomarkers during medical development is described in US Law under the 21st Century Cures Act. Information on how to submit biomarkers to the FDA and their context of use is defined herein.
C1 [Beger, Richard D.] US FDA, Natl Ctr Toxicol Res, Div Syst Biol, Jefferson, AR 72079 USA.
   [Schmidt, Michael A.] Adv Pattern Anal & Countermeasures Grp, Boulder, CO 80301 USA.
   [Schmidt, Michael A.] Sovaris Aerosp, Boulder, CO 80301 USA.
   [Kaddurah-Daouk, Rima] Duke Univ, Med Ctr, Duke Med, Psychiat & Behav Sci, Box 3903, Durham, NC 27710 USA.
   [Kaddurah-Daouk, Rima] Duke Univ, Med Ctr, Duke Inst Brain Sci, Box 3903, Durham, NC 27710 USA.
C3 US Food & Drug Administration (FDA); Duke University; Duke University
RP Beger, RD (通讯作者)，US FDA, Natl Ctr Toxicol Res, Div Syst Biol, Jefferson, AR 72079 USA.
EM Richard.Beger@fda.hhs.gov; mschmidtphd@patternanalysis.org;
   rima.kaddurahdaouk@duke.edu
OI Beger, Richard/0000-0003-4380-2356
CR Abo R, 2012, PHARMACOGENET GENOM, V22, P247, DOI 10.1097/FPC.0b013e32835001c9
   Ahmed MA, 2016, BMC PHARMACOL TOXICO, V17, DOI 10.1186/s40360-016-0088-3
   Ahmed S, 2016, GENOM PROTEOM BIOINF, V14, P298, DOI 10.1016/j.gpb.2016.03.008
   Alharbi TJ, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0204420
   Alvarez M, 2019, ENDOCR CONNECT, V8, P1324, DOI 10.1530/EC-19-0382
   [Anonymous], 2000, PHARMSCI
   Aroda VR, 2016, J CLIN ENDOCR METAB, V101, P1754, DOI 10.1210/jc.2015-3754
   Backshall A, 2011, CLIN CANCER RES, V17, P3019, DOI 10.1158/1078-0432.CCR-10-2474
   Beger RD, 2016, METABOLOMICS, V12, DOI 10.1007/s11306-016-1094-6
   Beger RD, 2016, METABOLOMICS, V12, DOI 10.1007/s11306-016-1061-2
   Ben-Shachar R, 2012, THEOR BIOL MED MODEL, V9, DOI 10.1186/1742-4682-9-55
   Bhattacharyya S, 2019, TRANSL PSYCHIAT, V9, DOI 10.1038/s41398-019-0507-5
   Bhattacharyya S, 2014, BIOMARK MED, V8, P147, DOI 10.2217/bmm.13.150
   Bi Y, 2015, INFECT DIS TRANSLAT, V1, P63
   Burt T, 2013, PHARMACOGENOMICS, V14, P1085, DOI [10.2217/PGS.13.81, 10.2217/pgs.13.81]
   Bushra Rabia, 2011, Oman Med J, V26, P77, DOI 10.5001/omj.2011.21
   Cao ZJ, 2019, J PROTEOME RES, V18, P2411, DOI 10.1021/acs.jproteome.8b00903
   Caterina P, 2013, J RES MED SCI, V18, P600
   Cattaneo D, 2012, J ANTIMICROB CHEMOTH, V67, P460, DOI 10.1093/jac/dkr498
   Chagoyen M, 2013, BRIEF BIOINFORM, V14, P737, DOI 10.1093/bib/bbs055
   Chapman L.E., 2019, MEDICINE, V98, pe17918
   Chen C, 2008, J BIOL CHEM, V283, P4543, DOI 10.1074/jbc.M706299200
   Clarke G, 2019, PHARMACOL REV, V71, P198, DOI 10.1124/pr.118.015768
   Clayton TA, 2009, P NATL ACAD SCI USA, V106, P14728, DOI 10.1073/pnas.0904489106
   Clayton TA, 2006, NATURE, V440, P1073, DOI 10.1038/nature04648
   Cooper-DeHoff RM, 2014, CIRC-CARDIOVASC GENE, V7, P199, DOI 10.1161/CIRCGENETICS.113.000421
   Daly AK, 2010, NAT REV GENET, V11, P241, DOI 10.1038/nrg2751
   David LA, 2014, NATURE, V505, P559, DOI 10.1038/nature12820
   de Jager J, 2010, BMJ-BRIT MED J, V340, DOI 10.1136/bmj.c2181
   de Oliveira FA, 2016, METABOLOMICS, V12, DOI 10.1007/s11306-016-1076-8
   Dethlefsen L, 2011, P NATL ACAD SCI USA, V108, P4554, DOI 10.1073/pnas.1000087107
   Drozda K, 2018, JACC-BASIC TRANSL SC, V3, P545, DOI 10.1016/j.jacbts.2018.06.001
   Ebbels TMD, 2007, J PROTEOME RES, V6, P4407, DOI 10.1021/pr0703021
   Elbadawi-Sidhu M, 2017, METABOLOMICS, V13, DOI 10.1007/s11306-016-1141-3
   Ellero-Simatos S, 2014, CPT-PHARMACOMET SYST, V3, DOI 10.1038/psp.2014.22
   Everett JR, 2015, PHARMACOGENOMICS, V16, P737, DOI [10.2217/PGS.15.20, 10.2217/pgs.15.20]
   Everett JR, 2013, ANN CLIN BIOCHEM, V50, P523, DOI 10.1177/0004563213497929
   Fearnley LG, 2016, INT J EPIDEMIOL, V45, P1319, DOI 10.1093/ije/dyw046
   Flores R, 2012, J TRANSL MED, V10, DOI 10.1186/1479-5876-10-253
   Frankel AE, 2017, NEOPLASIA, V19, P848, DOI 10.1016/j.neo.2017.08.004
   Garrett-Bakelman FE, 2019, SCIENCE, V364, P144, DOI 10.1126/science.aau8650
   Gerke S, 2018, PROCEDIA STRUCT INTE, V13, P39, DOI 10.1016/j.prostr.2018.12.007
   Goldsmith PM, 2017, BMJ OPEN, V7, DOI 10.1136/bmjopen-2017-016144
   Haiser HJ, 2012, SCIENCE, V336, P1253, DOI 10.1126/science.1224396
   Heintz-Buschart A, 2018, TRENDS MICROBIOL, V26, P563, DOI 10.1016/j.tim.2017.11.002
   Heruth DP, 2018, J PHARMACOL EXP THER, V367, P95, DOI 10.1124/jpet.118.248583
   Holbrook AM, 2005, ARCH INTERN MED, V165, P1095, DOI 10.1001/archinte.165.10.1095
   Hollands A, 2016, J BIOL CHEM, V291, P13964, DOI 10.1074/jbc.M115.695866
   Huang RL, 2011, SCI TRANSL MED, V3, DOI 10.1126/scitranslmed.3001862
   Huttenhower C, 2012, NATURE, V486, P207, DOI 10.1038/nature11234
   Jain D, 2017, ANN TRANSL MED, V5, DOI 10.21037/atm.2017.06.35
   Ji Y, 2011, CLIN PHARMACOL THER, V89, P97, DOI 10.1038/clpt.2010.250
   Kaddurah-Daouk R, 2007, MOL PSYCHIATR, V12, P934, DOI 10.1038/sj.mp.4002000
   Kaddurah-Daouk R, 2015, CLIN PHARMACOL THER, V98, P71, DOI 10.1002/cpt.134
   Kaddurah-Daouk R, 2014, CLIN PHARMACOL THER, V95, P154, DOI 10.1038/clpt.2013.217
   Kaddurah-Daouk R, 2008, ANNU REV PHARMACOL, V48, P653, DOI 10.1146/annurev.pharmtox.48.113006.094715
   Kaddurah-Daouk R, 2018, CPT-PHARMACOMET SYST, V7, P525, DOI 10.1002/psp4.12309
   Kaddurah-Daouk R, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0025482
   Kaddurah-Daouk R, 2010, METABOLOMICS, V6, P191, DOI 10.1007/s11306-010-0207-x
   Kantae V, 2017, METABOLOMICS, V13, DOI 10.1007/s11306-016-1143-1
   Ko SH, 2014, J KOREAN MED SCI, V29, P965, DOI 10.3346/jkms.2014.29.7.965
   Koppel N, 2017, SCIENCE, V356, DOI 10.1126/science.aag2770
   Lanznaster D, 2018, FRONT NEUROL, V9, DOI 10.3389/fneur.2018.01126
   Lazarou J, 1998, JAMA-J AM MED ASSOC, V279, P1200, DOI 10.1001/jama.279.15.1200
   Leptak C, 2017, SCI TRANSL MED, V9, DOI 10.1126/scitranslmed.aal4599
   Lewis JP, 2013, CLIN PHARMACOL THER, V94, P570, DOI 10.1038/clpt.2013.153
   Lindon JC, 2003, TOXICOL APPL PHARM, V187, P137, DOI 10.1016/S0041-008X(02)00079-0
   McEvoy J, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0068717
   Miller R, 2005, J PHARMACOKINET PHAR, V32, P185, DOI 10.1007/s10928-005-0074-7
   Miolo G, 2016, ONCOTARGET, V7, P39809, DOI 10.18632/oncotarget.9489
   MITCHELL JR, 1973, J PHARMACOL EXP THER, V187, P185
   Mohn ES, 2018, PHARMACEUTICS, V10, DOI 10.3390/pharmaceutics10010036
   Morais SM, 2017, PHARMACEUTICALS-BASE, V10, DOI 10.3390/ph10010031
   Mosedale M, 2017, CLIN PHARMACOL THER, V101, P469, DOI 10.1002/cpt.564
   Moyer AM, 2011, TOXICOL SCI, V120, P33, DOI 10.1093/toxsci/kfq375
   Muhrez K, 2017, PHARMACOL RES, V118, P121, DOI 10.1016/j.phrs.2016.05.021
   Neavin D, 2016, METABOLOMICS, V12, DOI 10.1007/s11306-016-1066-x
   Nicholson JK, 2006, MOL SYST BIOL, V2, DOI 10.1038/msb4100095
   Oh Jaeseong, 2018, Genomics & Informatics, V16, P52, DOI 10.5808/GI.2018.16.3.52
   Orlenko A, 2018, BIOCOMPUT-PAC SYM, P460
   Out M, 2018, J DIABETES COMPLICAT, V32, P171, DOI 10.1016/j.jdiacomp.2017.11.001
   Pirmohamed M, 2001, BRIT J CLIN PHARMACO, V52, P345, DOI 10.1046/j.0306-5251.2001.01498.x
   Rasool M, 2015, BMC MED GENOMICS, V8, DOI 10.1186/1755-8794-8-S1-S5
   Rattray NJW, 2017, METABOLOMICS, V13, DOI 10.1007/s11306-017-1191-1
   Reinstatler L, 2012, DIABETES CARE, V35, P327, DOI 10.2337/dc11-1582
   Roden DM, 2011, CIRCULATION, V123, P1661, DOI 10.1161/CIRCULATIONAHA.109.914820
   Rotroff DM, 2016, TRANSL PSYCHIAT, V6, DOI 10.1038/tp.2016.145
   Rotroff DM, 2015, CPT-PHARMACOMET SYST, V4, P669, DOI 10.1002/psp4.12017
   Saito Y, 2018, FEMS MICROBIOL ECOL, V94, DOI 10.1093/femsec/fiyD25
   Sanderson SM, 2019, NAT REV CANCER, V19, P625, DOI 10.1038/s41568-019-0187-8
   Sender R, 2016, PLOS BIOL, V14, DOI 10.1371/journal.pbio.1002533
   Shahin MH, 2018, J AM HEART ASSOC, V7, DOI 10.1161/JAHA.117.006656
   Shepherd G, 2012, ANN PHARMACOTHER, V46, P169, DOI 10.1345/aph.1P592
   Shuker N, 2016, TRANSPL INT, V29, P1158, DOI 10.1111/tri.12798
   Siccardi M, 2012, THER DRUG MONIT, V34, P232, DOI 10.1097/FTD.0b013e31824aa50a
   Stone NJ, 2014, CIRCULATION, V129, pS1, DOI 10.1161/01.cir.0000437738.63853.7a
   Swanson HI, 2015, DRUG METAB DISPOS, V43, P1499, DOI 10.1124/dmd.115.065714
   Szymanska E, 2012, METABOLOMICS, V8, pS3, DOI 10.1007/s11306-011-0330-3
   Trupp M, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0038386
   Turner RM, 2015, WIRES SYST BIOL MED, V7, P221, DOI 10.1002/wsbm.1302
   van Roekel EH, 2019, METABOLOMICS, V15, DOI 10.1007/s11306-018-1468-z
   Ventola C Lee, 2013, P T, V38, P545
   Wikoff WR, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0057639
   Wilkinson GR, 2005, NEW ENGL J MED, V352, P2211, DOI 10.1056/NEJMra032424
   Wilson ID, 2017, TRANSL RES, V179, P204, DOI 10.1016/j.trsl.2016.08.002
   Wilson ID, 2009, P NATL ACAD SCI USA, V106, P14187, DOI 10.1073/pnas.0907721106
   Xia JG, 2010, BIOINFORMATICS, V26, P2342, DOI 10.1093/bioinformatics/btq418
   Yerges-Armstrong LM, 2013, CLIN PHARMACOL THER, V94, P525, DOI 10.1038/clpt.2013.119
   Yip LY, 2015, DRUG METAB DISPOS, V43, P1619, DOI 10.1124/dmd.115.063750
NR 109
TC 32
Z9 33
U1 7
U2 20
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD APR
PY 2020
VL 10
IS 4
AR 129
DI 10.3390/metabo10040129
PG 19
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA LO8WV
UT WOS:000533907300025
PM 32230776
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Chen, PC
   Chien, YW
   Yang, SC
AF Chen, Pei-Chi
   Chien, Yi-Wen
   Yang, Suh-Ching
TI The alteration of gut microbiota in newly diagnosed type 2 diabetic
   patients
SO NUTRITION
LA English
DT Article
DE Human gut microbiota; Type 2 diabetes; Dysbiosis; Lactobacillus;
   Clostridium
ID BUTYRATE-PRODUCING BACTERIA; METFORMIN; OBESITY; METAGENOME
AB Objectives: Gut microbiota dysbiosis is known to be associated with diabetes; however, the findings of previous studies are conflicting. To clarify the association between type 2 diabetes and the gut microbiota, the present study analyzed the composition of fecal gut microbiota and its correlation with specific clinical parameters in newly diagnosed, treatment-naive diabetic patients and healthy controls.
   Methods: A total of 50 patients with newly diagnosed type 2 diabetes and 50 healthy control participants were enrolled in the study. Fecal samples, blood samples, and food diaries were collected from the diabetic patients before and 3 mo after the start of their antidiabetic treatment. These samples were also collected from the healthy controls. The gut microbiota was characterized by 16S ribosomal RNA analysis using quantitative polymerase chain reaction.
   Results: The fecal count of Lactobacillus was significantly higher, whereas Clostridium coccoides and Clostridium leptum were significantly lower in the diabetic patients compared with the healthy controls. Lactobacillus was significantly positively correlated with glucose, glycated hemoglobin, and the homeostatic model assessment, whereas C. coccoides and C. leptum were significantly negatively correlated with the diabetic parameters. In addition, the newly diagnosed diabetic patients had a significant decrease in the presence of C. coccoides and C. leptum after 3 mo of treatment compared with before treatment.
   Conclusions: The amount of fecal Lactobacillus, C coccoides, and C. leptum was significantly different between the patients with type 2 diabetes and the healthy controls. The levels of Clostridium were also significantly changed after 3 mo of treatment in the diabetic patients. Further research is needed to clarify the correlation or causal relationship between the gut microbiota dysbiosis and type 2 diabetes. (C) 2018 Elsevier Inc. All rights reserved.
C1 [Chen, Pei-Chi] Shin Kong Wu Ho Su Mem Hosp, Div Endocrinol & Metab, Taipei, Taiwan.
   [Chen, Pei-Chi; Chien, Yi-Wen; Yang, Suh-Ching] Taipei Med Univ, Sch Nutr & Hlth Sci, Taipei, Taiwan.
   [Chien, Yi-Wen; Yang, Suh-Ching] Taipei Med Univ, Coll Nutr, Res Ctr Geriatr Nutr, Taipei, Taiwan.
   [Yang, Suh-Ching] Taipei Med Univ Hosp, Nutr Res Ctr, Taipei, Taiwan.
C3 Shin Kong Wu Ho Su Memorial Hospital; Taipei Medical University; Taipei
   Medical University; Taipei Medical University; Taipei Medical University
   Hospital
RP Yang, SC (通讯作者)，Taipei Med Univ, Sch Nutr & Hlth Sci, Taipei, Taiwan.; Yang, SC (通讯作者)，Taipei Med Univ, Coll Nutr, Res Ctr Geriatr Nutr, Taipei, Taiwan.; Yang, SC (通讯作者)，Taipei Med Univ Hosp, Nutr Res Ctr, Taipei, Taiwan.
EM sokei@tmu.edu.tw
FU Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan
   [SKH-8302-102-DR-08]
FX The present study was supported by a research grant (grant no.
   SKH-8302-102-DR-08) from the Shin Kong Wu Ho-Su Memorial Hospital,
   Taipei, Taiwan.
CR American Diabetes Association, 2018, Diabetes Care, V41, pS13, DOI 10.2337/dc18-S002
   Angelakis E, 2012, FUTURE MICROBIOL, V7, P91, DOI [10.2217/FMB.11.142, 10.2217/fmb.11.142]
   Bhute SS, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.00214
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Duncan SH, 2007, APPL ENVIRON MICROB, V73, P1073, DOI 10.1128/AEM.02340-06
   Duvallet C, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-01973-8
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Fraher MH, 2012, NAT REV GASTRO HEPAT, V9, P312, DOI 10.1038/nrgastro.2012.44
   Hartstra AV, 2015, DIABETES CARE, V38, P159, DOI 10.2337/dc14-0769
   Hippe B, 2016, BENEF MICROBES, V7, P511, DOI 10.3920/BM2015.0075
   Hur KY, 2015, DIABETES METAB J, V39, P198, DOI 10.4093/dmj.2015.39.3.198
   Jackson MA, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-018-05184-7
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Lai MS, 2012, J FORMOS MED ASSOC, V111, P587, DOI 10.1016/j.jfma.2012.08.016
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Lau E, 2015, HORM-INT J ENDOCRINO, V14, P358, DOI 10.14310/horm.2002.1571
   Lin HV, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0035240
   Louis P, 2009, FEMS MICROBIOL LETT, V294, P1, DOI 10.1111/j.1574-6968.2009.01514.x
   McCreight LJ, 2016, DIABETOLOGIA, V59, P426, DOI 10.1007/s00125-015-3844-9
   Mehta NN, 2010, DIABETES, V59, P172, DOI 10.2337/db09-0367
   Montandon SA, 2017, GENES-BASEL, V8, DOI 10.3390/genes8100250
   Musso G, 2010, DIABETES CARE, V33, P2277, DOI 10.2337/dc10-0556
   Poretsky R, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0093827
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Riviere A, 2016, FRONT MICROBIOL, V7, DOI 10.3389/fmicb.2016.00979
   Sato J, 2014, DIABETES CARE, V37, P2343, DOI 10.2337/dc13-2817
   Singh RK, 2017, J TRANSL MED, V15, DOI 10.1186/s12967-017-1175-y
   Teixeira TFS, 2013, CLIN NUTR, V32, P1017, DOI 10.1016/j.clnu.2013.02.008
   Thursby E, 2017, BIOCHEM J, V474, P1823, DOI 10.1042/BCJ20160510
   Wang HB, 2012, DIGEST DIS SCI, V57, P3126, DOI 10.1007/s10620-012-2259-4
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Xu F, 2009, DIABETES, V58, pA3, DOI 10.2337/db08-1637
NR 32
TC 28
Z9 30
U1 3
U2 25
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD JUL-AUG
PY 2019
VL 63-64
BP 51
EP 56
DI 10.1016/j.nut.2018.11.019
PG 6
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA ID5SC
UT WOS:000471735300008
PM 30933725
DA 2023-06-08
ER

PT J
AU Li, JJ
   Yuan, HM
   Zhao, ZQ
   Li, L
   Li, XQ
   Zhu, LY
   Wang, X
   Sun, P
   Xiao, YP
AF Li, Jinjun
   Yuan, Huimin
   Zhao, Zhiqi
   Li, Li
   Li, Xiaoqiong
   Zhu, Liying
   Wang, Xin
   Sun, Ping
   Xiao, Yinping
TI The mitigative effect of isorhamnetin against type 2 diabetes via gut
   microbiota regulation in mice
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE isorhamnetin; type 2 diabetes; fasting blood glucose; gut microbiota;
   lipid metabolism
ID INSULIN; ASSOCIATION; METFORMIN; OBESITY; DIET
AB In order to demonstrate the effects of isorhamnetin (IH) on the symptoms of type 2 diabetes mellitus (T2DM) and the role of gut microbiota in this process, an T2DM mouse model was established via a high-fat diet and streptozotocin. After 6 weeks of IH intervention and diabetes phenotype monitoring, the mice were dissected. We detected blood indicators and visceral pathology. Contents of the cecum were collected for 16S rRNA sequencing and short chain fatty acid (SCFAs) detection. The results showed that after IH intervention, the body weight of type 2 diabetic mice was gradually stabilized, fasting blood glucose was significantly decreased, and food intake was reduced (P < 0.05). Isorhamnetin significantly increased the level of SCFAs and decreased the levels of blood lipids and inflammatory factors in mice (P < 0.05). 16S rRNA sequencing results showed that Lactobacillus were significantly decreased and Bacteroidales S24-7 group_norank were significantly increased (P < 0.05). Interestingly, gut microbiota was significantly correlated with inflammatory factors, blood lipids, and SCFAs (P < 0.05). Taken together, our data demonstrated that isorhamnetin could improve the diabetic effects in T2DM mice, which might be mediated by gut microbiota.
C1 [Li, Jinjun; Zhao, Zhiqi; Li, Xiaoqiong; Wang, Xin; Xiao, Yinping] Zhejiang Acad Agr Sci, State Key Lab Managing Biot & Chem Threats Qual &, Hangzhou, Peoples R China.
   [Li, Jinjun; Yuan, Huimin; Li, Xiaoqiong; Wang, Xin] Zhejiang Acad Agr Sci, Inst Food Sci, Hangzhou, Peoples R China.
   [Li, Jinjun] Minist Agr & Rural Affairs, Key Lab Postharvest Preservat & Proc Vegetables Co, Hangzhou, Peoples R China.
   [Yuan, Huimin; Zhu, Liying; Sun, Ping] Shanxi Med Univ, Sch Publ Hlth, Taiyuan, Peoples R China.
   [Zhao, Zhiqi] Shanxi Med Univ, Sch Basic Med Sci, Dept Pharmacol, Taiyuan, Peoples R China.
   [Li, Li] Hangzhou Normal Univ, Clin Med Coll, Hangzhou, Peoples R China.
C3 Zhejiang Academy of Agricultural Sciences; Zhejiang Academy of
   Agricultural Sciences; Ministry of Agriculture & Rural Affairs; Shanxi
   Medical University; Shanxi Medical University; Hangzhou Normal
   University
RP Xiao, YP (通讯作者)，Zhejiang Acad Agr Sci, State Key Lab Managing Biot & Chem Threats Qual &, Hangzhou, Peoples R China.; Sun, P (通讯作者)，Shanxi Med Univ, Sch Publ Hlth, Taiyuan, Peoples R China.
EM sunping888@126.com; xiaozj@hotmail.com
RI li, yang/IQV-3559-2023; LI, XIAO/IQV-9318-2023
FU R&D Program of Zhejiang; Zhejiang Provincial Natural Science Foundation
   of China [2022C03138]; Zhendong National Human Quality and Health
   Research Fund [LQ20C200009];  [CNS-ZD2020-88]
FX This research was funded by "Pioneer" and "Leading Goose" R & D Program
   of Zhejiang, grant/award number: 2022C03138, Zhejiang Provincial Natural
   Science Foundation of China under Grant No. LQ20C200009, and Zhendong
   National Human Quality and Health Research Fund (Grant No.
   CNS-ZD2020-88).
CR Cheru L, 2019, CURR OBES REP, V8, P165, DOI 10.1007/s13679-019-00332-6
   Christensen DP, 2011, MOL MED, V17, P378, DOI 10.2119/molmed.2011.00021
   Dalekos GN, 1997, J LAB CLIN MED, V129, P300, DOI 10.1016/S0022-2143(97)90178-5
   DeFronzo RA, 2015, NAT REV DIS PRIMERS, V1, DOI 10.1038/nrdp.2015.19
   Dror E, 2017, NAT IMMUNOL, V18, P283, DOI 10.1038/ni.3659
   Dujic T, 2015, DIABETES, V64, P1786, DOI 10.2337/db14-1388
   Elbere I, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0204317
   Galicia-Garcia U, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21176275
   Gao L, 2017, MOL CELL BIOCHEM, V429, P167, DOI 10.1007/s11010-017-2944-x
   Gheibi S, 2017, BIOMED PHARMACOTHER, V95, P605, DOI 10.1016/j.biopha.2017.08.098
   Horie M, 2017, EXP ANIM TOKYO, V66, P405, DOI 10.1538/expanim.17-0021
   Ishola IO, 2019, BRAIN RES, V1712, P188, DOI 10.1016/j.brainres.2019.02.017
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Li J, 2021, ANN TRANSL MED, V9, DOI 10.21037/atm-21-3532
   Luo Y, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0120259
   Ma QT, 2019, BIOMED PHARMACOTHER, V117, DOI 10.1016/j.biopha.2019.109138
   Macfarlane S, 2003, P NUTR SOC, V62, P67, DOI 10.1079/PNS2002207
   Mandaliya DK, 2019, PANCREATOLOGY, V19, P280, DOI 10.1016/j.pan.2019.01.021
   Matboli M, 2021, EPIGENOMICS-UK, V13, P187, DOI 10.2217/epi-2020-0353
   Matboli M, 2021, BIOMED PHARMACOTHER, V135, DOI 10.1016/j.biopha.2020.111176
   Otify AM, 2021, STEROIDS, V173, DOI 10.1016/j.steroids.2021.108888
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Qiu J, 2019, J CLIN LAB ANAL, V33, DOI 10.1002/jcla.22842
   Qiu SJ, 2016, BIOMED REP, V4, P628, DOI 10.3892/br.2016.636
   Rabkin SW, 2009, NAT CLIN PRACT CARD, V6, P192, DOI 10.1038/ncpcardio1453
   Raso GM, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0068626
   Rodriguez-Rodriguez C, 2015, FOOD FUNCT, V6, P805, DOI [10.1039/c4fo01092b, 10.1039/C4FO01092B]
   Roy Claude C, 2006, Nutr Clin Pract, V21, P351, DOI 10.1177/0115426506021004351
   Saeedi P, 2019, DIABETES RES CLIN PR, V157, DOI 10.1016/j.diabres.2019.107843
   Salaritabar A, 2017, WORLD J GASTROENTERO, V23, P5097, DOI 10.3748/wjg.v23.i28.5097
   Sanchez-Rangel E, 2017, DIABETOLOGIA, V60, P1586, DOI 10.1007/s00125-017-4336-x
   Sato J, 2014, DIABETES CARE, V37, P2343, DOI 10.2337/dc13-2817
   Shen J, 2013, MOL ASPECTS MED, V34, P39, DOI 10.1016/j.mam.2012.11.001
   Tedelind S, 2007, WORLD J GASTROENTERO, V13, P2826, DOI 10.3748/wjg.v13.i20.2826
   Thaiss CA, 2018, SCIENCE, V362, P903, DOI 10.1126/science.aav6870
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Wang H, 2022, FOODS, V11, DOI 10.3390/foods11121747
   Wang K, 2021, EXP THER MED, V22, DOI 10.3892/etm.2021.10484
   Wang MM, 2018, MOL THER, V26, P1921, DOI 10.1016/j.ymthe.2018.06.013
   Wang Shao-Jin, 2008, Zhen Ci Yan Jiu, V33, P154
   Wang Y, 2012, APPL ENVIRON MICROB, V78, P8264, DOI 10.1128/AEM.01821-12
   Wang Zhu, 2010, Wei Sheng Yan Jiu, V39, P133
   Wen HT, 2011, NAT IMMUNOL, V12, P408, DOI 10.1038/ni.2022
   Xu L, 2018, THERANOSTICS, V8, P5593, DOI 10.7150/thno.27425
   Xue BH, 2021, STEM CELL RES THER, V12, DOI 10.1186/s13287-021-02205-z
   Yonekura-Sakakibara K, 2019, FRONT PLANT SCI, V10, DOI 10.3389/fpls.2019.00943
   Zhang XY, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0071108
NR 47
TC 2
Z9 2
U1 6
U2 6
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD DEC 22
PY 2022
VL 9
AR 1070908
DI 10.3389/fnut.2022.1070908
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 7O0RS
UT WOS:000907741300001
PM 36618710
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Wu, BW
   Tan, L
   Wang, WH
   Feng, XZ
   Yan, D
AF Wu, Bowen
   Tan, Li
   Wang, Weihua
   Feng, Xingzhong
   Yan, Dan
TI Imidazole Propionate is Increased in Diabetes and Associated with Stool
   Consistency
SO DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
LA English
DT Article
DE ImP; T2DM; stool consistency; bile acids
ID BILE-ACIDS; GUT MICROBIOTA; POPULATION; RECEPTOR
AB Background: Imidazole Propionate (ImP) is a new marker of Type 2 diabetes mellitus (T2DM), which can induce impaired glucose metabolism and weaken the efficacy of metformin. An extensive exploration into literature suggests that ImP may be associated with stool consistency. Purpose: Through an in-depth study of the relationship between stool consistency, bile acids, fecal microbiota and ImP, we intend to explore the mechanism driving the ImP content difference in T2DM. Patients Under Study and Methods: This is a single-center, prospective, cross-sectional study. Plasma ImP and stool consistency were analyzed among 96 diabetic subjects and 45 healthy subjects. All subjects were divided into the stool consistency normal (N) group and the stool consistency abnormal group, of which the abnormal group was sub-divided into the hard stool (H) group and the soft stool (S) group. After identifying the correlation between ImP and stool consistency, we analyzed the influence of bile acids and fecal microbiota on ImP in diabetic subjects. Results: For T2DM patients, the ImP level of the abnormal stool consistency group was significantly higher than that of the normal stool consistency group (P < 0.001). Results were verified in 45 healthy subjects (P = 0.002). ImP was significantly associated with taurocholic acid (TCA) (P = 0.003) in feces, taurodeoxycholate (TDCA) (P = 0.003), glycochenodeoxycholate (GCDCA) (P = 0.021), and glycocholic acid (GCA) (P = 0.031) in plasma. The Shannon index of Group N was significantly higher than that of Group H (P = 0.041) and Group S (P = 0.003). Conclusion: ImP was higher in diabetic patients with abnormal stool consistency than in those with normal stool consistency, which was related to the proportion of bile acids and fecal microbial structure. These findings may improve our understanding of ImP and contribute to the treatment of T2DM by improving stool consistency.
C1 [Wu, Bowen; Yan, Dan] Capital Med Univ, Beijing Friendship Hosp, 95 Yongan Rd, Beijing, Peoples R China.
   [Tan, Li] Capital Med Univ, Beijing Shijitan Hosp, Beijing, Peoples R China.
   [Wang, Weihua] Tsinghua Univ, Ctr Pharmaceut Technol, Beijing, Peoples R China.
   [Feng, Xingzhong] Tsinghua Univ, Yuquan Hosp, 5 Shijingshan Rd, Beijing, Peoples R China.
   [Yan, Dan] Beijing Inst Clin Pharm, Beijing, Peoples R China.
   [Yan, Dan] Beijing Lab Evaluat Rational Drug Use, Beijing, Peoples R China.
C3 Capital Medical University; Capital Medical University; Tsinghua
   University; Tsinghua University
RP Yan, D (通讯作者)，Capital Med Univ, Beijing Friendship Hosp, 95 Yongan Rd, Beijing, Peoples R China.; Feng, XZ (通讯作者)，Tsinghua Univ, Yuquan Hosp, 5 Shijingshan Rd, Beijing, Peoples R China.
EM fengxz9797@sina.com; pharmsci@126.com
FU Capital Clinical Characteristic Application Research and Achievement
   Promotion Project [Z161100000516076]; National Natural Science
   Foundation of China [82130112]
FX We would like to thank all participants in the present study. This work
   was supported by Capital Clinical Characteristic Application Research
   and Achievement Promotion Project (Z161100000516076) and the National
   Natural Science Foundation of China (82130112) . The authors declare no
   competing financial interests.
CR Ahmed F, 2022, GUT, V71, P214, DOI 10.1136/gutjnl-2021-324396
   Alemi F, 2013, GASTROENTEROLOGY, V144, P145, DOI 10.1053/j.gastro.2012.09.055
   Allada R, 2021, NEW ENGL J MED, V384, P550, DOI 10.1056/NEJMra1802337
   Bogachev AV, 2012, MOL MICROBIOL, V86, P1452, DOI 10.1111/mmi.12067
   Bunnett NW, 2014, J PHYSIOL-LONDON, V592, P2943, DOI 10.1113/jphysiol.2014.271155
   Burton Jeffrey H, 2015, J Diabetes Sci Technol, V9, P808, DOI 10.1177/1932296815577425
   Camilleri M, 2020, AM J GASTROENTEROL, V115, P1596, DOI 10.14309/ajg.0000000000000696
   Cani PD, 2019, NAT REV ENDOCRINOL, V15, P69, DOI 10.1038/s41574-018-0143-9
   Chen PB, 2020, NAT BIOTECHNOL, V38, P1288, DOI 10.1038/s41587-020-0549-5
   Fan Y, 2021, NAT REV MICROBIOL, V19, P55, DOI 10.1038/s41579-020-0433-9
   Gram-Kampmann EM, 2022, DIABETES OBES METAB, V24, P693, DOI 10.1111/dom.14633
   Hibberd AA, 2019, BENEF MICROBES, V10, P121, DOI 10.3920/BM2018.0028
   Jia W, 2021, PROTEIN CELL, V12, P411, DOI 10.1007/s13238-020-00804-9
   Koh A, 2020, CELL METAB, V32, P643, DOI 10.1016/j.cmet.2020.07.012
   Koh A, 2018, CELL, V175, P947, DOI 10.1016/j.cell.2018.09.055
   Misawa N, 2020, ALIMENT PHARM THER, V52, P821, DOI 10.1111/apt.15950
   Molinaro A, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-19589-w
   Pedersen HK, 2016, NATURE, V535, P376, DOI 10.1038/nature18646
   Riba B, 2020, SCI TRANSL MED, V12, DOI 10.1126/scitranslmed.aay7019
   Tanes C, 2021, CELL HOST MICROBE, V29, P394, DOI 10.1016/j.chom.2020.12.012
   Tian Y, 2020, GUT MICROBES, V11, DOI 10.1080/19490976.2020.1732268
   van Best N, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-17183-8
   Vandeputte D, 2016, GUT, V65, P57, DOI 10.1136/gutjnl-2015-309618
   VANDERHEIDEN C, 1972, CLIN CHIM ACTA, V39, P201, DOI 10.1016/0009-8981(72)90317-8
   Vijayvargiya P, 2019, ALIMENT PHARM THER, V49, P744, DOI 10.1111/apt.15106
   von Schwartzenberg RJ, 2021, NATURE, V595, P272, DOI 10.1038/s41586-021-03663-4
   Vuong HE, 2020, NATURE, V586, P281, DOI 10.1038/s41586-020-2745-3
   Wang LY, 2020, GUT MICROBES, V12, P1, DOI 10.1080/19490976.2020.1819155
   Wang S, 2019, MICROBIOME, V7, DOI 10.1186/s40168-019-0740-4
   Wilmanski T, 2019, NAT BIOTECHNOL, V37, P1217, DOI 10.1038/s41587-019-0233-9
   Worthmann A, 2017, NAT MED, V23, P839, DOI 10.1038/nm.4357
   Wu H, 2020, CELL METAB, V32, P379, DOI 10.1016/j.cmet.2020.06.011
   Yamamoto M, 2019, METABOLOMICS, V15, DOI 10.1007/s11306-019-1543-0
   Yap CX, 2021, CELL, V184, P5916, DOI 10.1016/j.cell.2021.10.015
NR 34
TC 1
Z9 1
U1 1
U2 2
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7007
J9 DIABET METAB SYND OB
JI Diabetes Metab. Syndr. Obes.
PY 2022
VL 15
BP 1715
EP 1724
DI 10.2147/DMSO.S362715
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 2D4KE
UT WOS:000811517200002
PM 35698651
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Feng, XP
   Wang, DC
   Hu, LL
   Lu, HS
   Ling, B
   Huang, YN
   Jiang, QY
AF Feng, Xueping
   Wang, Decai
   Hu, Linlin
   Lu, Haishan
   Ling, Bo
   Huang, Yanna
   Jiang, Qinyang
TI Dendrobium officinale polysaccharide ameliorates polycystic ovary
   syndrome via regulating butyrate dependent gut-brain-ovary axis
   mechanism
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE dendrobium officinale polysaccharide; polycystic ovary syndrome; ovary;
   gut microbiota; butyrate
ID METFORMIN; PCOS; MICROBIOTA; WOMEN; RAT
AB Research has shown that dendrobium officinale polysaccharide (DOP) can promote follicular development and inhibit the apoptosis of ovarian granular cells in PCOS rats. However, DOP cannot be absorbed directly by the stomach and small intestine but is degraded into short-chain fatty acids by gut microbiota in the large intestine and regulates the composition of gut microbiota. How DOP improved ovarian function in PCOS rats through the blood-brain barrier is unclear. In this study, we generated letrozole-induced PCOS rat models and studied the therapeutic effect and mechanism of DOP. 16S rRNA amplicon sequencing analysis, GC-MS short-chain fatty acid detection, and Gene Expression Omnibus database searching were conducted to screen the significantly changed pathways, and a series of experiments, such as enzyme-linked immunosorbent assay, RT-qPCR, Western blot, and immunohistochemistry, were performed. We found that DOP treatment could improve ovarian morphology and endocrine disorders, restore the normal estrus cycle, increase gut microbiota a diversity, and alter beta diversity and enrichment of butyrate-producing bacterium in PCOS rats. In addition, compared with PCOS rats, those treated with DOP exhibited higher butyrate and polypeptide YY levels, possibly due to the regulation of G protein-coupled receptor 41 expression. These results indicated that DOP relieved the symptoms of PCOS rats which may be related to the mechanism of butyrate dependent gut-brain-ovary axis protection.
C1 [Feng, Xueping; Huang, Yanna; Jiang, Qinyang] Guangxi Univ, Coll Anim Sci & Technol, Nanning, Peoples R China.
   [Feng, Xueping] Youjiang Med Univ Nationalities, Coll Basic Med, Baise, Peoples R China.
   [Wang, Decai] Youjiang Med Univ Nationalities, Dept Lib, Baise, Peoples R China.
   [Hu, Linlin] Youjiang Med Univ Nationalities, Reprod Med Ctr, Affiliated Hosp, Baise, Peoples R China.
   [Lu, Haishan] Youjiang Med Univ Nationalities, Dept Pathol, Affiliated Hosp, Baise, Peoples R China.
   [Ling, Bo] Youjiang Med Univ Nationalities, Coll Pharm, Baise, Peoples R China.
C3 Guangxi University; Youjiang Medical University for Nationalities;
   Youjiang Medical University for Nationalities; Youjiang Medical
   University for Nationalities; Youjiang Medical University for
   Nationalities; Youjiang Medical University for Nationalities
RP Huang, YN; Jiang, QY (通讯作者)，Guangxi Univ, Coll Anim Sci & Technol, Nanning, Peoples R China.
EM huangyn@.gxu.edu.cn; jiangqinyang2013@gxu.edu.cn
RI wang, decai/GQP-8840-2022
FU Natural Science Foundation of Guangxi Province [2020JJB140033]
FX This work was supported by the Natural Science Foundation of Guangxi
   Province (Grant No. 2020JJB140033) in China.
CR Bozdag G, 2016, HUM REPROD, V31, P2841, DOI 10.1093/humrep/dew218
   Chen MY, 2020, INT J BIOL MACROMOL, V155, P890, DOI 10.1016/j.ijbiomac.2019.11.047
   Chen MY, 2022, THERANOSTICS, V12, P782, DOI 10.7150/thno.67167
   Cora MC, 2015, TOXICOL PATHOL, V43, P776, DOI 10.1177/0192623315570339
   D'Afflitto M, 2022, J CLIN GASTROENTEROL, V56, P384, DOI 10.1097/MCG.0000000000001676
   Demirel F, 2007, CLIN ENDOCRINOL, V67, P129, DOI 10.1111/j.1365-2265.2007.02849.x
   Domecq JP, 2013, J CLIN ENDOCR METAB, V98, P4646, DOI 10.1210/jc.2013-2374
   Ejtahed HS, 2016, HORM METAB RES, V48, P349, DOI 10.1055/s-0042-107792
   Ejtahed HS, 2019, EUR J ENDOCRINOL, V180, P165, DOI [10.1530/EJE-18-0826, 10.1530/eje-18-0826]
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Fruzzetti F, 2017, GYNECOL ENDOCRINOL, V33, P39, DOI 10.1080/09513590.2016.1236078
   Graff SK, 2016, INT J CLIN PRACT, V70, P450, DOI 10.1111/ijcp.12787
   Guo YJ, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0153196
   Haudum C, 2020, NUTRIENTS, V12, DOI 10.3390/nu12061622
   He JW, 2020, ENVIRON POLLUT, V266, DOI 10.1016/j.envpol.2020.115111
   He L, 2020, TRENDS PHARMACOL SCI, V41, P868, DOI 10.1016/j.tips.2020.09.001
   He YF, 2022, CARBOHYD POLYM, V287, DOI 10.1016/j.carbpol.2022.119304
   He YF, 2020, FOOD FUNCT, V11, P5192, DOI [10.1039/c9fo02554e, 10.1039/C9FO02554E]
   Henning SM, 2018, EUR J NUTR, V57, P2759, DOI 10.1007/s00394-017-1542-8
   Hu TG, 2019, J NAT PROD, V82, P2189, DOI 10.1021/acs.jnatprod.9b00205
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Koh A, 2016, CELL, V165, P1332, DOI 10.1016/j.cell.2016.05.041
   Li LF, 2019, J AGR FOOD CHEM, V67, P5968, DOI 10.1021/acs.jafc.9b01489
   Li X, 2015, AM J TRANSL RES, V7, P574
   Liu R, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.00324
   Luo AX, 2009, INT J BIOL MACROMOL, V45, P359, DOI 10.1016/j.ijbiomac.2009.07.008
   Nishitsuji K, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-16189-5
   Pedersen HK, 2016, NATURE, V535, P376, DOI 10.1038/nature18646
   Prattichizzo F, 2018, AGEING RES REV, V48, P87, DOI 10.1016/j.arr.2018.10.003
   Qu J, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.659626
   Richter EL., 2011, RUMEN MICROBIAL POPU, P26
   Roa J, 2009, ENDOCRINOLOGY, V150, P5016, DOI 10.1210/en.2009-0096
   Rodriguez J, 2018, CURR OPIN CLIN NUTR, V21, P294, DOI 10.1097/MCO.0000000000000468
   Saad MJA, 2016, PHYSIOLOGY, V31, P283, DOI 10.1152/physiol.00041.2015
   Song Xi, 2018, Oncotarget, V9, P11905, DOI 10.18632/oncotarget.24190
   Teede HJ, 2018, MED J AUSTRALIA, V209, pS3, DOI 10.5694/mja18.00656
   Wang MX, 2020, MED SCI MONITOR, V26, DOI 10.12659/MSM.922136
   Wang T, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.00284
   Wang XJ, 2022, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.806331
   Wang Z, 2019, CARBOHYD POLYM, V207, P502, DOI 10.1016/j.carbpol.2018.11.091
   Wei W, 2017, MOLECULES, V22, DOI 10.3390/molecules22010155
   Wickenheisser JK, 2000, J CLIN ENDOCR METAB, V85, P2304, DOI 10.1210/jc.85.6.2304
   Wu YY, 2018, BIOMED PHARMACOTHER, V101, P953, DOI 10.1016/j.biopha.2018.03.030
   Wu Y, 2016, MEDIAT INFLAMM, V2016, DOI 10.1155/2016/6456018
   Xie SZ, 2016, FOOD FUNCT, V7, P2789, DOI 10.1039/c6fo00172f
   Yaba A, 2012, J OVARIAN RES, V5, DOI 10.1186/1757-2215-5-38
   Yang S, 2014, PHYTOMEDICINE, V21, P712, DOI 10.1016/j.phymed.2013.10.026
   Yurtdas G, 2020, J AM COLL NUTR, V39, P371, DOI 10.1080/07315724.2019.1657515
   Zeng B, 2019, RES MICROBIOL, V170, P43, DOI 10.1016/j.resmic.2018.09.002
   Zhang GY, 2016, J AGR FOOD CHEM, V64, P2485, DOI 10.1021/acs.jafc.5b03117
   Zhang JC, 2019, MSYSTEMS, V4, DOI 10.1128/mSystems.00017-19
   Zhang S, 2020, INT J BIOL MACROMOL, V149, P826, DOI 10.1016/j.ijbiomac.2020.01.196
   Zhao H, 2021, REPROD HEALTH, V18, DOI 10.1186/s12978-021-01207-7
   Zhao XX, 2020, GEBURTSH FRAUENHEILK, V80, P161, DOI 10.1055/a-1081-2036
NR 54
TC 0
Z9 0
U1 5
U2 13
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD AUG 5
PY 2022
VL 13
AR 962775
DI 10.3389/fendo.2022.962775
PG 15
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 4I8AQ
UT WOS:000850796800001
PM 35992123
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Yoon, HJ
   Kim, HN
   Yun, Y
   Kim, Y
   Ha, AN
   Kim, HL
   Kim, BS
AF Yoon, Hai-Jeon
   Kim, Han-Na
   Yun, Yeojun
   Kim, Yemi
   Ha, Ae-Na
   Kim, Hyung-Lae
   Kim, Bom Sahn
TI Background Intestinal F-18-FDG Uptake Is Related to Serum Lipid Profile
   and Obesity in Breast Cancer Patients
SO PLOS ONE
LA English
DT Article
ID GUT MICROBIOTA; GLUCOSE; METABOLISM; METFORMIN
AB Background
   This study investigated the relationships between background intestinal uptake on F-18-FDG PET and cardio-metabolic risk (CMR) factors.
   Methods
   A total of 326 female patients that underwent F-18-FDG PET to determine the initial stage of breast cancer were enrolled. None of the patients had history of diabetes or hypertension. The background intestinal uptake on PET was visually graded (low vs. high uptake group) and quantitatively measured using the maximal standardized uptake value (SUVmax). SUVmax of 7 bowel segments (duodenum, jejunum, ileum, cecum, hepatic flexure, splenic flexure, and descending colon-sigmoid junction) were averaged for the total bowel (TB SUVmax). Age, body mass index (BMI), fasting blood glucose level (BST), triglyceride (TG), cholesterol, high density lipoprotein (HDL), and low density lipoprotein (LDL) were the considered CMR factors. The relationships between background intestinal F-18-FDG uptake on PET and diverse CMR factors were analyzed.
   Results
   The visual grades based on background intestinal F-18-FDG uptake classified 100 (30.7%) patients into the low uptake group, while 226 (69.3%) were classified into the high uptake group. Among CMR factors, age (p = 0.004), BMI (p<0.001), and TG (p<0.001) were significantly different according to visual grade of background intestinal F-18-FDG uptake. Quantitative TB SUVmax showed significant positive correlation with age (r = 0.203, p<0.001), BMI (r = 0.373, p<0.001), TG (r = 0.338, p<0.001), cholesterol (r = 0.148, p = 0.008), and LDL (r = 0.143, p = 0.024) and significant negative correlation with HDL (r = -0.147, p = 0.022). Multivariate analysis indicated that BMI and TG were independent factors in both visually graded background intestinal F-18-FDG uptake (p = 0.027 and p = 0.023, respectively) and quantitatively measured TB SUVmax (p = 0.006 and p = 0.004, respectively).
   Conclusion
   Increased background intestinal 18F-FDG uptake on PET may suggest alteration of lipid metabolism and risk of cardio-metabolic disease in non-diabetic and non-hypertensive breast cancer patients.
C1 [Yoon, Hai-Jeon; Kim, Bom Sahn] Ewha Womans Univ, Sch Med, Dept Nucl Med, Seoul, South Korea.
   [Kim, Han-Na; Yun, Yeojun; Kim, Hyung-Lae] Ewha Womans Univ, Dept Biochem, Sch Med, Seoul, South Korea.
   [Kim, Yemi; Ha, Ae-Na; Kim, Bom Sahn] Ewha Womans Univ, Med Res Inst, Sch Med, Seoul, South Korea.
C3 Ewha Womans University; Ewha Womans University; Ewha Womans University
RP Kim, HL (通讯作者)，Ewha Womans Univ, Dept Biochem, Sch Med, Seoul, South Korea.
EM hyung@ewha.ac.kr; kbomsahn@ewha.ac.kr
FU Ewha Womans University [1-2015-1057-001-1, 1-2014-1676-001-1]; National
   Research Foundation [2015R1C1A1A02037051, 2012M3A9B6055379,
   NRF-2014R1A2A2A04006291]
FX This research was supported by grants from Ewha Womans University
   (1-2015-1057-001-1 and 1-2014-1676-001-1) and the National Research
   Foundation (2015R1C1A1A02037051, 2012M3A9B6055379, and
   NRF-2014R1A2A2A04006291). The funders had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript.
CR Backhed F, 2004, P NATL ACAD SCI USA, V101, P15718, DOI 10.1073/pnas.0407076101
   Backhed F, 2007, P NATL ACAD SCI USA, V104, P979, DOI 10.1073/pnas.0605374104
   BAILEY CJ, 1994, BRIT J PHARMACOL, V112, P671, DOI 10.1111/j.1476-5381.1994.tb13128.x
   Chatterjee A, 2012, CAN FAM PHYSICIAN, V58, P389
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Cook GJR, 2004, SEMIN NUCL MED, V34, P122, DOI 10.1053/j.semnuclmed.2003.12.003
   Fava F, 2006, CURR MED CHEM, V13, P3005, DOI 10.2174/092986706778521814
   FEINGOLD KR, 1992, J LIPID RES, V33, P1765
   Franquet E, 2014, NUCL MED COMMUN, V35, P1026, DOI 10.1097/MNM.0000000000000170
   Gill SR, 2006, SCIENCE, V312, P1355, DOI 10.1126/science.1124234
   Gontier E, 2008, EUR J NUCL MED MOL I, V35, P95, DOI 10.1007/s00259-007-0563-6
   GORBACH SL, 1984, REV INFECT DIS, V6, pS85
   Greiner T, 2011, TRENDS ENDOCRIN MET, V22, P117, DOI 10.1016/j.tem.2011.01.002
   Harris K, 2012, J OBES, V2012, DOI 10.1155/2012/879151
   Kim Seok ki, 1999, Clin Positron Imaging, V2, P273, DOI 10.1016/S1095-0397(99)00030-8
   Ley RE, 2008, SCIENCE, V320, P1647, DOI 10.1126/science.1155725
   Maitra U, 2011, J IMMUNOL, V186, P4467, DOI 10.4049/jimmunol.1003300
   Oh JR, 2010, AM J ROENTGENOL, V195, P1404, DOI 10.2214/AJR.10.4663
   PENICAUD L, 1989, BIOCHEM J, V262, P881, DOI 10.1042/bj2620881
   Stephenson GD, 2003, NUTR CANCER, V45, P1, DOI 10.1207/S15327914NC4501_1
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Walker J, 2005, BIOCHEM J, V385, P485, DOI 10.1042/BJ20040694
   Xu DB, 2014, GASTROENTEROLOGY, V146, P484, DOI 10.1053/j.gastro.2013.10.026
   Yasuda Seiei, 1998, Tokai Journal of Experimental and Clinical Medicine, V23, P241
NR 24
TC 6
Z9 6
U1 0
U2 11
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD NOV 2
PY 2015
VL 10
IS 11
AR e0141473
DI 10.1371/journal.pone.0141473
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA CV1PG
UT WOS:000364029800010
PM 26523374
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Kim, J
   Lee, H
   An, J
   Song, Y
   Lee, CK
   Kim, K
   Kong, H
AF Kim, Jiyeon
   Lee, Heetae
   An, Jinho
   Song, Youngcheon
   Lee, Chong-Kil
   Kim, Kyungjae
   Kong, Hyunseok
TI Alterations in Gut Microbiota by Statin Therapy and Possible
   Intermediate Effects on Hyperglycemia and Hyperlipidemia
SO FRONTIERS IN MICROBIOLOGY
LA English
DT Article
DE atorvastatin; rosuvastatin; gut microbiota; IL-1 beta; TGF beta 1;
   short-chain fatty acid
ID CHAIN FATTY-ACIDS; INSULIN SENSITIVITY; IMMUNE-SYSTEM; ROSUVASTATIN;
   OBESITY; METFORMIN; DISEASE; ATORVASTATIN; CHOLESTEROL; IMPROVEMENT
AB Dysbiosis of the gut microbiota is a contributing factor for obesity-related metabolic diseases such as hyperglycemia and hyperlipidemia. Pharmacotherapy for metabolic diseases involves the modulation of gut microbiota, which is suggested to be a potential therapeutic target. In this study, the modulation of gut microbiota by statins (cholesterol-lowering drugs: atorvastatin and rosuvastatin) was investigated in an aged mouse model of high-fat diet-induced obesity, and the association between gut microbiota and immune responses was described. Atorvastatin and rosuvastatin significantly increased the abundance of the genera Bacteroides, Butyricimonas, and Mucispirillum. Moreover, the abundance of these genera was correlated with the inflammatory response, including levels of IL-1 beta and TGF beta 1 in the ileum. In addition, oral fecal microbiota transplantation with fecal material collected from rosuvastatin-treated mouse groups improved hyperglycemia. From these results, the effect of statins on metabolic improvements could be explained by altered gut microbiota. Our findings suggest that the modulation of gut microbiota by statins has an important role in the therapeutic actions of these drugs.
C1 [Kim, Jiyeon; Lee, Heetae; An, Jinho; Song, Youngcheon; Kim, Kyungjae] Sahmyook Univ, Coll Pharm, Seoul, South Korea.
   [Lee, Chong-Kil] Chungbuk Natl Univ, Coll Pharm, Cheongju, South Korea.
   [Kong, Hyunseok] Sahmyook Univ, Coll Anim Biotechnol & Resource, Seoul, South Korea.
C3 Sahmyook University; Chungbuk National University; Sahmyook University
RP Kong, H (通讯作者)，Sahmyook Univ, Coll Anim Biotechnol & Resource, Seoul, South Korea.
EM hskong0813@gmail.com
FU Korea Institute of Planning and Evaluation for Technology in Food,
   Agriculture, Forestry, and Fisheries, IPET [314044-3]
FX This research was supported by the Korea Institute of Planning and
   Evaluation for Technology in Food, Agriculture, Forestry, and Fisheries,
   IPET (No. 314044-3).
CR Abbas A, 2012, CLIN MED INSIGHTS-EN, V5, P13, DOI 10.4137/CMED.S7591
   Al-Sadi RM, 2007, J IMMUNOL, V178, P4641, DOI 10.4049/jimmunol.178.7.4641
   Bauche D, 2017, CLIN TRANSL IMMUNOL, V6, DOI 10.1038/cti.2017.9
   Cahenzli J, 2013, CELL HOST MICROBE, V14, P559, DOI 10.1016/j.chom.2013.10.004
   Caparros-Martin JA, 2017, MICROBIOME, V5, DOI 10.1186/s40168-017-0312-4
   Caporaso JG, 2010, NAT METHODS, V7, P335, DOI 10.1038/nmeth.f.303
   Clarke SF, 2012, GUT MICROBES, V3, P186, DOI 10.4161/gmic.20168
   Collado MC, 2007, APPL ENVIRON MICROB, V73, P7767, DOI 10.1128/AEM.01477-07
   Delzenne NM, 2011, NAT REV ENDOCRINOL, V7, P639, DOI 10.1038/nrendo.2011.126
   den Besten G, 2013, J LIPID RES, V54, P2325, DOI 10.1194/jlr.R036012
   Esquivel-Elizondo S, 2017, MSYSTEMS, V2, DOI 10.1128/mSystems.00051-17
   Felix-Redondo FJ, 2013, AGING DIS, V4, P154
   Fentoglu O, 2011, J CLIN PERIODONTOL, V38, P8, DOI 10.1111/j.1600-051X.2010.01644.x
   Finlayson A, 2015, WORLD J GASTRO ENDOS, V7, P1103, DOI [10.4253/wjge.v7.i13.1103, 10.4291/wjgp.v6.i4.110]
   Fuks G, 2018, MICROBIOME, V6, DOI 10.1186/s40168-017-0396-x
   Geirnaert A, 2014, ANAEROBE, V30, P70, DOI 10.1016/j.anaerobe.2014.08.010
   Gilbert JA, 2010, STAND GENOMIC SCI, V3, P249, DOI [10.4056/aigs.1443528, 10.4056/sigs.1433550]
   Goncalves P, 2018, INFLAMM BOWEL DIS, V24, P558, DOI 10.1093/ibd/izx029
   Gordon A., 2010, FASTX TOOLKIT FASTQ
   Hong SW, 2017, IMMUNE NETW, V17, P48, DOI 10.4110/in.2017.17.1.48
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Jia LL, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-07335-0
   Karkman A, 2017, ANN NY ACAD SCI, V1399, P78, DOI 10.1111/nyas.13326
   Kashiwagi I, 2015, IMMUNITY, V43, P65, DOI 10.1016/j.immuni.2015.06.010
   Khan TJ, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-017-19013-2
   Kootte RS, 2017, CELL METAB, V26, P611, DOI 10.1016/j.cmet.2017.09.008
   Layton A, 2006, APPL ENVIRON MICROB, V72, P4214, DOI 10.1128/AEM.01036-05
   Lee H, 2018, GUT MICROBES, V9, P155, DOI 10.1080/19490976.2017.1405209
   Lee H, 2016, SCI REP-UK, V6, DOI 10.1038/srep25835
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Lee SE, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0194490
   Lee S, 2016, BIOCHEM BIOPH RES CO, V478, P1242, DOI 10.1016/j.bbrc.2016.08.101
   Letterio JJ, 1998, ANNU REV IMMUNOL, V16, P137, DOI 10.1146/annurev.immunol.16.1.137
   Ley RE, 2006, NATURE, V444, P1022, DOI 10.1038/4441022a
   Liu YH, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.00530
   Louis S, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0149564
   Loy A, 2017, MSYSTEMS, V2, DOI 10.1128/mSystems.00171-16
   Mardinoglu A, 2016, CELL METAB, V23, P10, DOI 10.1016/j.cmet.2015.12.012
   Markowiak P, 2017, NUTRIENTS, V9, DOI 10.3390/nu9091021
   Massague J, 2012, NAT REV MOL CELL BIO, V13, P616, DOI 10.1038/nrm3434
   Nolan JA, 2017, AM J PHYSIOL-GASTR L, V312, pG488, DOI 10.1152/ajpgi.00149.2016
   Porreca E, 2002, J AM COLL CARDIOL, V39, P1752, DOI 10.1016/S0735-1097(02)01857-0
   Rintala Anniina, 2017, J Biomol Tech, V28, P19, DOI 10.7171/jbt.17-2801-003
   Rotter V, 2003, J BIOL CHEM, V278, P45777, DOI 10.1074/jbc.M301977200
   Round JL, 2010, P NATL ACAD SCI USA, V107, P12204, DOI 10.1073/pnas.0909122107
   Safeer RS, 2000, AM FAM PHYSICIAN, V61, P3371
   Sanz Y, 2015, PEDIATR RES, V77, P236, DOI 10.1038/pr.2014.170
   Segata N, 2011, GENOME BIOL, V12, DOI 10.1186/gb-2011-12-6-r60
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Stancu C, 2001, J CELL MOL MED, V5, P378, DOI 10.1111/j.1582-4934.2001.tb00172.x
   Stone NJ, 2014, CIRCULATION, V129, pS1, DOI 10.1161/01.cir.0000437738.63853.7a
   Talsness CE, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0188011
   Wang YF, 2008, OBESITY, V16, P2323, DOI 10.1038/oby.2008.351
   Wilson ID, 2009, CURR PHARM DESIGN, V15, P1519, DOI 10.2174/138161209788168173
   Winer DA, 2016, CELL METAB, V23, P413, DOI 10.1016/j.cmet.2016.01.003
   Wu HJ, 2012, GUT MICROBES, V3, P4, DOI 10.4161/gmic.19320
   Xu F, 2009, DIABETES, V58, pA3, DOI 10.2337/db08-1637
   Yang JY, 2017, MUCOSAL IMMUNOL, V10, P104, DOI 10.1038/mi.2016.42
   Young SG, 2012, NEW ENGL J MED, V366, P1154, DOI 10.1056/NEJMe1202168
NR 59
TC 78
Z9 82
U1 0
U2 13
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-302X
J9 FRONT MICROBIOL
JI Front. Microbiol.
PD SEP 4
PY 2019
VL 10
AR 1947
DI 10.3389/fmicb.2019.01947
PG 10
WC Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology
GA IU7CI
UT WOS:000483741600001
PM 31551944
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Afolayan, AO
   Adebusoye, LA
   Cadmus, EO
   Ayeni, FA
AF Afolayan, A. O.
   Adebusoye, L. A.
   Cadmus, E. O.
   Ayeni, F. A.
TI Insights into the gut microbiota of Nigerian elderly with type 2
   diabetes and non-diabetic elderly persons
SO HELIYON
LA English
DT Article
DE Microbiology; Ecology; Bioinformatics; Genetics; Health sciences; Type 2
   diabetes; Elderly; Gut microbiota; Nigeria
ID S-ADENOSYLMETHIONINE; ALTERS; METAGENOME; SIGNATURE; METFORMIN; MICE;
   DIET
AB Type 2 diabetes (T2D) is a prevalent non-communicable disease among the world's growing elderly population. The contribution of the gut microbiota to T2D in several Westernized countries has been established. However, there is little information on the role of the gut microbiota in T2D from the African continent where lifestyle and life expectancy are different.
   Aims: This study sought to investigate gut microbiota variation in relation to elderly people living with T2D. in Nigeria.
   Methods: Whole microbial community DNA were derived from the stool samples of healthy urban-dwelling elderly individuals and urban-dwelling elderly individuals with T2D. The V4 region of the 16S rRNA gene was Illumina-sequenced and analyzed using QIIME2.
   Results: Beta taxonomic diversity was significantly different between healthy elderly individuals and elderly individuals with T2D. However, no difference in the alpha taxonomic diversity and predicted functional alpha diversity of the gut microbiota was observed. The genus Ruminococcus (T2D versus Healthy: 2.89% vs 2.21%), families Coriobacteriaceae (Collinsella, T2D versus Healthy: 2.62 % vs 1.25%) and Bifidobacteriaceae were enriched in elderly individuals with T2D, while members of Clostridiaceae (Clostridium, Healthy versus T2D: 5.6% vs 3.2%) and Peptostreptococcaceae (Healthy versus T2D: 3.45% vs 1.99%) were enriched in healthy volunteers. Pathways involved in amino acid biosynthesis were enriched in elderly individuals with T2D, while pathways involved in respiration and the biosynthesis of vital building blocks were enriched in healthy volunteers.
   Conclusions: The study demonstrated for the first time in an African elderly population that the abundance of Bifidobacteriaceae, Collinsella, and Ruminococcus within the gut varies in relation to T2D. Findings from this study suggest that the restoration of features associated with healthiness via the way of gut microbiota modification could be one step needed to improve elderly patient care.
C1 [Afolayan, A. O.; Ayeni, F. A.] Univ Ibadan, Fac Pharm, Dept Pharmaceut Microbiol, Ibadan, Nigeria.
   [Adebusoye, L. A.; Cadmus, E. O.] Univ Coll Hosp, Chief Tony Anenih Geriatr Ctr, Ibadan, Oyo State, Nigeria.
   [Cadmus, E. O.] Univ Ibadan, Coll Med, Dept Community Med, Ibadan, Nigeria.
C3 University of Ibadan; University of Ibadan; University College Hospital,
   Ibadan; University of Ibadan
RP Ayeni, FA (通讯作者)，Univ Ibadan, Fac Pharm, Dept Pharmaceut Microbiol, Ibadan, Nigeria.
EM funmiyeni@yahoo.co.uk
OI Afolayan, Ayorinde/0000-0003-1405-2365; Cadmus,
   Eniola/0000-0002-0201-1462
FU Austrian Agency for International Cooperation in Education and Research
   (OEAD-GmbH)
FX This work was supported by an Austrian Agency for International
   Cooperation in Education and Research (OEAD-GmbH). postdoctoral
   fellowship awarded to Afolayan AO tenable at Medical University of Graz,
   Graz, Austria.
CR Adeloye D, 2017, BMJ OPEN, V7, DOI 10.1136/bmjopen-2016-015424
   Afolayan AO, 2019, FRONT MICROBIOL, V10, DOI 10.3389/fmicb.2019.02138
   Anjana RM, 2011, DIABETOLOGIA, V54, P3022, DOI 10.1007/s00125-011-2291-5
   Ayeni FA, 2018, CELL REP, V23, P3056, DOI 10.1016/j.celrep.2018.05.018
   Bansal N, 2015, MED CLIN N AM, V99, P351, DOI 10.1016/j.mcna.2014.11.008
   Barengolts E, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0194171
   Bhute SS, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.00214
   Biagi E, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0010667
   Blekhman R, 2016, SCI REP-UK, V6, DOI 10.1038/srep31519
   Bolyen E., 2018, PEERJPREPRINTS, V6
   Cai LH, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0140827
   Callahan BJ, 2016, NAT METHODS, V13, P581, DOI [10.1038/NMETH.3869, 10.1038/nmeth.3869]
   Cani PD, 2009, GUT, V58, P1091, DOI 10.1136/gut.2008.165886
   Cinek O, 2018, DIABETES RES CLIN PR, V144, P51, DOI 10.1016/j.diabres.2018.08.010
   Daniel H, 2014, ISME J, V8, P295, DOI 10.1038/ismej.2013.155
   Fan PX, 2017, SCI REP-UK, V7, DOI 10.1038/srep43412
   Flint H.J., 2012, GUT MICROB, V3
   Giesbertz P, 2015, DIABETOLOGIA, V58, P2133, DOI 10.1007/s00125-015-3656-y
   Herrmann W, 2005, CLIN CHEM, V51, P891, DOI 10.1373/clinchem.2004.044453
   International Diabetes Federation, 2019, IDF DIABETES ATLAS, P119
   International Diabetes Federation, 2017, IDF DIAB ATL 2021, V8th
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Karlsson JC, 2012, ORGANIZATIONAL MISBEHAVIOUR IN THE WORKPLACE: NARRATIVES OF DIGNITY AND RESISTANCE, P3
   Klymiuk I, 2016, FRONT MICROBIOL, V7, DOI 10.3389/fmicb.2016.02012
   Landgraf BJ, 2016, ANNU REV BIOCHEM, V85, P485, DOI 10.1146/annurev-biochem-060713-035504
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Ley RE, 2006, NATURE, V444, P1022, DOI 10.1038/4441022a
   Loftfield E, 2016, CANCER EPIDEM BIOMAR, V25, P1483, DOI 10.1158/1055-9965.EPI-16-0409
   Lu YH, 2019, METABOLITES, V9, DOI 10.3390/metabo9010014
   Marlene R., 2013, J DIABETES METABOL, P1
   Mathers CD, 2006, PLOS MED, V3, DOI 10.1371/journal.pmed.0030442
   McCreight LJ, 2016, DIABETOLOGIA, V59, P426, DOI 10.1007/s00125-015-3844-9
   Newton RJ, 2013, MICROB ECOL, V65, P1011, DOI 10.1007/s00248-013-0200-9
   Nsubuga AM, 2004, MOL ECOL, V13, P2089, DOI 10.1111/j.1365-294X.2004.02207.x
   Ogbera AO, 2014, WORLD J DIABETES, V5, P905, DOI 10.4239/wjd.v5.i6.905
   Ou JH, 2013, AM J CLIN NUTR, V98, P111, DOI 10.3945/ajcn.112.056689
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Ramezani A, 2016, AM J KIDNEY DIS, V67, P483, DOI 10.1053/j.ajkd.2015.09.027
   Samuel G, 2003, CARBOHYD RES, V338, P2503, DOI 10.1016/j.carres.2003.07.009
   Schnorr SL, 2014, NAT COMMUN, V5, DOI 10.1038/ncomms4654
   Sedighi M, 2017, MICROB PATHOGENESIS, V111, P362, DOI 10.1016/j.micpath.2017.08.038
   Shin NR, 2015, TRENDS BIOTECHNOL, V33, P496, DOI 10.1016/j.tibtech.2015.06.011
   Vazquez-Baeza Y, 2013, GIGASCIENCE, V2, DOI 10.1186/2047-217X-2-16
   Wang Y, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0172774
   Wiklund P, 2016, SCI REP-UK, V6, DOI 10.1038/srep24540
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Wu XK, 2010, CURR MICROBIOL, V61, P69, DOI 10.1007/s00284-010-9582-9
   Zakrzewski M, 2017, BIOINFORMATICS, V33, P782, DOI 10.1093/bioinformatics/btw725
   Zhang XY, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0071108
NR 49
TC 8
Z9 9
U1 0
U2 11
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
EI 2405-8440
J9 HELIYON
JI Heliyon
PD MAY
PY 2020
VL 6
IS 5
AR e03971
DI 10.1016/j.heliyon.2020.e03971
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA LU4TO
UT WOS:000537749900124
PM 32490229
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Liang, Z
   Di, N
   Li, L
   Yang, D
AF Liang, Z.
   Di, N.
   Li, L.
   Yang, D.
TI Gut microbiota alterations reveal potential gut-brain axis changes in
   polycystic ovary syndrome
SO JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
LA English
DT Article
DE Polycystic ovary syndrome; Overweight; Gut microbiota;
   Gamma-aminobutyric acid; Gut&#8211; brain axis
ID PREVALENCE; CRITERIA; OBESITY; WOMEN
AB Purpose Polycystic ovary syndrome (PCOS) is a common heterogeneous endocrine disorder companied with neuroendocrine and metabolic disorders. Gut microbiota has been implicated to play a key role in metabolic diseases and the production of neurotransmitters. Previous studies have reported the alterations in the gut microbiota of PCOS patients and animal models, however, most of the articles did not take the effect of age or diet on gut microbiota into account. The aim of this study was to identify the differential gut microbial species in PCOS patients compared with age and BMI-matched healthy control women. Methods We performed physical examinations and dietary survey in 20 women with PCOS (lean PCOS, PL, n = 10; overweight PCOS, PO, n = 10) and 20 healthy control women (lean control, CL, n = 10; overweight control, CO, n = 10), and collected the blood on the days 1-3 of the menstrual cycle for the measurement of endocrine and metabolic profiles, and inflammatory factors; and collected the feces in non-menstrual period to investigate the composition of gut microbiota by sequencing the V4 region of the 16S rDNA gene in fecal samples. The correlations between clinical parameters and the differential species were evaluated. Results Dietary analysis showed that the intake of dietary fiber, vitamin D were significantly decreased in PCOS. For the first time, our study found an increase of gamma-aminobutyric acid (GABA)-producing species in PCOS, including Parabacteroides distasonis, Bacteroides fragilis and Escherichia coli, which significantly positively correlated with serum LH levels and LH:FSH ratios. Conclusions GABA-producing bacteria that were increased in PCOS, including Parabacteroides distasonis, Bacteroides fragilis and Escherichia coli, showed positive relationship with serum LH levels and LH:FSH ratios. In conclusion, gut microbial dysbiosis in women with PCOS is associated with neuroendocrine changes, revealing a potential gut-brain axis in PCOS.
C1 [Liang, Z.; Li, L.; Yang, D.] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Obstet & Gynecol, Guangzhou, Peoples R China.
   [Di, N.] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Ultrasound, Guangzhou, Peoples R China.
C3 Sun Yat Sen University; Sun Yat Sen University
RP Li, L; Yang, D (通讯作者)，Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Obstet & Gynecol, Guangzhou, Peoples R China.
EM lilinsums@163.com; yangfuchanke@163.com
FU National Natural Science Youth Fund [81703784]; Sun Yat-sen University
   5010 Youth Project [2017015]; National Key Research and development
   Program of China [SQ2017YFSF080004]; Sun Yat-sen University 5010 project
   [2014005]
FX This research and researchers were funded as follows: Lin Li by the
   National Natural Science Youth Fund (81703784), and 2017 Sun Yat-sen
   University 5010 Youth Project: A randomized controlled trial comparing
   the efficacy and safety of berberine versus metformin for polycystic
   ovary syndrome with metabolic disorders (2017015). Dongzi Yang by the
   National Key Research and development Program of China
   (SQ2017YFSF080004), and 2014 Sun Yat-sen University 5010 project: A
   long-term follow-up study on metabolic abnormalities and outcomes in
   patients with polycystic ovary syndrome (2014005).
CR Azziz R., 2006, ANDROGEN EXCESS DISO, V2nd
   Barba C, 2004, LANCET, V363, P157, DOI 10.1016/S0140-6736(03)15268-3
   Boursier J, 2015, PLOS PATHOG, V11, DOI 10.1371/journal.ppat.1004559
   Brandsma E, 2015, CURR OPIN LIPIDOL, V26, P73, DOI 10.1097/MOL.0000000000000154
   Caporaso JG, 2010, NAT METHODS, V7, P335, DOI 10.1038/nmeth.f.303
   Chen XL, 2010, HUM REPROD, V25, P1295, DOI 10.1093/humrep/deq028
   DiBaise JK, 2008, MAYO CLIN PROC, V83, P460, DOI 10.4065/83.4.460
   Edgar RC, 2013, NAT METHODS, V10, P996, DOI [10.1038/nmeth.2604, 10.1038/NMETH.2604]
   Edgar RC, 2011, BIOINFORMATICS, V27, P2194, DOI 10.1093/bioinformatics/btr381
   Edgar RC, 2010, BIOINFORMATICS, V26, P2460, DOI 10.1093/bioinformatics/btq461
   Escobar-Morreale HF, 2011, FERTIL STERIL, V95, P1048, DOI 10.1016/j.fertnstert.2010.11.036
   Fadrosh DW, 2014, MICROBIOME, V2, DOI 10.1186/2049-2618-2-6
   Fauser BCJM, 2004, HUM REPROD, V19, P41, DOI 10.1093/humrep/deh098
   Filippou P, 2017, HUM REPROD UPDATE, V23, P421, DOI 10.1093/humupd/dmx013
   Goodarzi MO, 2011, NAT REV ENDOCRINOL, V7, P219, DOI 10.1038/nrendo.2010.217
   Insenser M, 2018, J CLIN ENDOCR METAB, V103, P2552, DOI 10.1210/jc.2017-02799
   Janssen AWF, 2015, FASEB J, V29, P3111, DOI 10.1096/fj.14-269514
   Karlsson FH, 2012, NAT COMMUN, V3, DOI 10.1038/ncomms2266
   Kawwass JF, 2017, HUM REPROD, V32, P1450, DOI 10.1093/humrep/dex086
   Kerckhoffs APM, 2009, WORLD J GASTROENTERO, V15, P2887, DOI 10.3748/wjg.15.2887
   Lauritsen MP, 2014, HUM REPROD, V29, P791, DOI 10.1093/humrep/det469
   Li R, 2013, HUM REPROD, V28, P2562, DOI 10.1093/humrep/det262
   Lim SS, 2012, HUM REPROD UPDATE, V18, P618, DOI 10.1093/humupd/dms030
   Lindheim L, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0168390
   Liu R, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.00324
   Magoc T, 2011, BIOINFORMATICS, V27, P2957, DOI 10.1093/bioinformatics/btr507
   March WA, 2010, HUM REPROD, V25, P544, DOI 10.1093/humrep/dep399
   Mathur R, 2010, DIGEST DIS SCI, V55, P1085, DOI 10.1007/s10620-009-0890-5
   Olson CA, 2018, CELL, V173, P1728, DOI [10.1016/j.cell.2018.06.051, 10.1016/j.cell.2018.04.027]
   Porter DT, 2019, ENDOCRINOLOGY, V160, P2529, DOI 10.1210/en.2019-00137
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Schloss PD, 2009, APPL ENVIRON MICROB, V75, P7537, DOI 10.1128/AEM.01541-09
   Sherman SB, 2018, GUT MICROBES, V9, P400, DOI 10.1080/19490976.2018.1441664
   Silva MSB, 2019, EBIOMEDICINE, V44, P582, DOI 10.1016/j.ebiom.2019.05.065
   Sonnenburg ED, 2016, NATURE, V529, P212, DOI 10.1038/nature16504
   Strandwitz P, 2019, NAT MICROBIOL, V4, P396, DOI 10.1038/s41564-018-0307-3
   Targher G, 2016, ENDOCRINE, V51, P211, DOI 10.1007/s12020-015-0640-8
   Torres PJ, 2018, J CLIN ENDOCR METAB, V103, P1502, DOI 10.1210/jc.2017-02153
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Wilkinson TJ, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.01095
   Zeng B, 2019, RES MICROBIOL, V170, P43, DOI 10.1016/j.resmic.2018.09.002
   Zhang JC, 2019, MSYSTEMS, V4, DOI 10.1128/mSystems.00017-19
NR 42
TC 18
Z9 19
U1 4
U2 28
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0391-4097
EI 1720-8386
J9 J ENDOCRINOL INVEST
JI J. Endocrinol. Invest.
PD AUG
PY 2021
VL 44
IS 8
BP 1727
EP 1737
DI 10.1007/s40618-020-01481-5
EA JAN 2021
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA TJ4CT
UT WOS:000604169400002
PM 33387350
DA 2023-06-08
ER

PT J
AU Zhang, FF
   Mao, T
   Cui, P
   Tamadon, A
   He, S
   Huo, CB
   Yierfulati, G
   Xu, XQ
   Hu, W
   Li, X
   Shao, LR
   Guol, HW
   Feng, Y
   Xu, CJ
AF Zhang, Feifei
   Mao, Tong
   Cui, Peng
   Tamadon, Amin
   He, Shan
   Huo, Chuanbing
   Yierfulati, Gulinazi
   Xu, Xiaoqing
   Hu, Wei
   Li, Xin
   Shao, Linus R.
   Guol, Hongwei
   Feng, Yi
   Xu, Congjian
TI Diversity of the Gut Microbiota in Dihydrotestosterone-Induced PCOS Rats
   and the Pharmacologic Effects of Diane-35, Probiotics, and Berberine
SO FRONTIERS IN MICROBIOLOGY
LA English
DT Article
DE gut microbiota; PCOS; DHT; Diane-35; probiotics; berberine
ID POLYCYSTIC-OVARY-SYNDROME; HIGH-FAT-DIET; INSULIN-RESISTANCE; WOMEN;
   OBESITY; MANAGEMENT; METFORMIN; FEATURES; SENSITIVITY; PREVALENCE
AB Polycystic ovary syndrome (PCOS) is a frequent endocrine and metabolic syndrome in reproductive-age women. Recently, emerging evidence has shown that gut microbiota is closely related to metabolic diseases such as type 2 diabetes, obesity and PCOS. In the present study, we established dihydrotestosterone (DHT)-induced PCOS rats and used Illumina MiSeq sequencing (PE300) to examine the composition, diversity, and abundance of the gut microbiota in PCOS. We compared the effects of three PCOS treatments: Diane-35 (estrogen and progesterone), probiotics and berberine. The DHT-induced rats showed constant estrous cycles, the loss of mature ovarian follicles, insulin resistance and obesity. The reproductive and metabolic functions in the PCOS rats were improved by treatment with Diane-35 and probiotics. Diane-35 and probiotics could restore the diversity of the gut microbiota, and the recovery of gut microbiota disorders improved the reproductive function in PCOS-like rats. However, berberine drastically reduced the species diversity and amount of gut microbiota and showed no improvement in PCOS. The findings of this study will help us to better understand the influence of the gut microbiota in the metabolic and reproductive alterations in PCOS as well as suggest opportunities for future personal dietary guidance for PCOS.
C1 [Zhang, Feifei; Guol, Hongwei] Fudan Univ, Sch Publ Hlth, Shanghai, Peoples R China.
   [Zhang, Feifei; Li, Xin; Xu, Congjian] Fudan Univ, Obstet & Gynecol, Shanghai Med Coll, Shanghai, Peoples R China.
   [Zhang, Feifei; Li, Xin; Xu, Congjian] Shanghai Key Lab Female Reprod Endocrine Related, Shanghai, Peoples R China.
   [Mao, Tong; Cui, Peng; Tamadon, Amin; He, Shan; Huo, Chuanbing; Yierfulati, Gulinazi; Xu, Xiaoqing; Hu, Wei; Feng, Yi] Fudan Univ, Dept Integrat Med & Neurobiol, State Key Lab Med Neurobiol,Brain Sci Collaborat, Inst Brain Sci,Sch Basic Med Sci,Fudan Inst Integ, Shanghai, Peoples R China.
   [Shao, Linus R.] Univ Gothenburg, Sahlgrenska Acad, Dept Physiol Endocrinol, Inst Neurosci & Physiol, Gothenburg, Sweden.
C3 Fudan University; Fudan University; Fudan University; University of
   Gothenburg
RP Xu, CJ (通讯作者)，Fudan Univ, Obstet & Gynecol, Shanghai Med Coll, Shanghai, Peoples R China.; Xu, CJ (通讯作者)，Shanghai Key Lab Female Reprod Endocrine Related, Shanghai, Peoples R China.; Feng, Y (通讯作者)，Fudan Univ, Dept Integrat Med & Neurobiol, State Key Lab Med Neurobiol,Brain Sci Collaborat, Inst Brain Sci,Sch Basic Med Sci,Fudan Inst Integ, Shanghai, Peoples R China.
EM fengi17@fuden.edu.cn; xuconjian@fuden.edu.cn
RI Shao, Linus R/M-3134-2019; xu, cj/HJZ-3488-2023; Feng, Yi/P-6817-2019;
   Shao, Linus R/M-3059-2019; Tamadon, Amin/J-5794-2013
OI Shao, Linus R/0000-0002-1339-9570; Feng, Yi/0000-0002-7156-6023; Shao,
   Linus R/0000-0002-1339-9570; Tamadon, Amin/0000-0002-0222-3035; Cui,
   Peng/0000-0002-4566-6223
FU National Natural Science Foundation of China [NSFC 81673766, NSFC
   81572555]; Development Project of Shanghai Peak Disciplines-Integrative
   Medicine [20180101]; Shanghai Municipal Commission of Health and Family
   Planning [2017ZZ01016, 201640362]
FX This research was funded by the National Natural Science Foundation of
   China (NSFC 81673766) and Development Project of Shanghai Peak
   Disciplines-Integrative Medicine (20180101) to YF, the Shanghai
   Municipal Commission of Health and Family Planning (201640362) to FZ,
   the National Natural Science Foundation of China (NSFC 81572555) to XL,
   the Shanghai Municipal Commission of Health and Family Planning
   (2017ZZ01016) to CX.
CR Akcali A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0108074
   Ali Aus Tariq, 2015, Ceska Gynekol, V80, P279
   Bargiota A, 2012, THER ADV ENDOCRINOL, V3, P27, DOI 10.1177/2042018812437355
   Ben-Shlomo Izhar, 2003, Reprod Biomed Online, V6, P36
   Brook I, 2005, J LARYNGOL OTOL, V119, P251, DOI 10.1258/0022215054020304
   Cani PD, 2007, DIABETOLOGIA, V50, P2374, DOI 10.1007/s00125-007-0791-0
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   Conway G, 2014, EUR J ENDOCRINOL, V171, pP1, DOI 10.1530/EJE-14-0253
   Diamanti-Kandarakis E, 2007, TRENDS ENDOCRIN MET, V18, P280, DOI 10.1016/j.tem.2007.07.004
   DiBaise JK, 2008, MAYO CLIN PROC, V83, P460, DOI 10.4065/83.4.460
   Fadrosh DW, 2014, MICROBIOME, V2, DOI 10.1186/2049-2618-2-6
   Faghfoori Z, 2017, DIABETES METAB SYND, V11, pS429, DOI 10.1016/j.dsx.2017.03.030
   Fernandez-Real JM, 2012, DIABETOLOGIA, V55, P273, DOI 10.1007/s00125-011-2387-y
   Guo YJ, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0153196
   Hildebrandt MA, 2009, GASTROENTEROLOGY, V137, P1716, DOI 10.1053/j.gastro.2009.08.042
   Hoeger KM, 2012, FERTIL STERIL, V97, P13, DOI 10.1016/j.fertnstert.2011.11.026
   Holzapfel WH, 2001, AM J CLIN NUTR, V73, p365S, DOI 10.1093/ajcn/73.2.365s
   Huang JC, 2016, J FUNCT FOODS, V26, P763, DOI 10.1016/j.jff.2016.08.042
   Ibanez L, 2004, J CLIN ENDOCR METAB, V89, P1592, DOI 10.1210/jc.2003-031281
   Kelley ST, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0146509
   KIDDY DS, 1992, CLIN ENDOCRINOL, V36, P105, DOI 10.1111/j.1365-2265.1992.tb02909.x
   Le Chatelier E, 2013, NATURE, V500, P541, DOI 10.1038/nature12506
   Lecomte V, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0126931
   Ley RE, 2006, CELL, V124, P837, DOI 10.1016/j.cell.2006.02.017
   Ley RE, 2005, P NATL ACAD SCI USA, V102, P11070, DOI 10.1073/pnas.0504978102
   Li GH, 2012, GASTROENT RES PRACT, V2012, DOI 10.1155/2012/404752
   Li R, 2013, HUM REPROD, V28, P2562, DOI 10.1093/humrep/det262
   Li Y, 2013, TRIALS, V14, DOI 10.1186/1745-6215-14-226
   Li ZH, 2008, WORLD J PEDIATR, V4, P45, DOI 10.1007/s12519-008-0009-7
   Lim MY, 2017, GUT, V66, P1031, DOI 10.1136/gutjnl-2015-311326
   March WA, 2010, HUM REPROD, V25, P544, DOI 10.1093/humrep/dep399
   MARCONDES F. K., 2002, Braz. J. Biol., V62, P609, DOI 10.1590/S1519-69842002000400008
   Marotz Clarisse A., 2016, Yale Journal of Biology and Medicine, V89, P383
   Mayer EA, 2011, NAT REV NEUROSCI, V12, P453, DOI 10.1038/nrn3071
   McElhoe JA, 2014, FORENSIC SCI INT-GEN, V13, P20, DOI 10.1016/j.fsigen.2014.05.007
   Michelmore KF, 1999, CLIN ENDOCRINOL, V51, P779, DOI 10.1046/j.1365-2265.1999.00886.x
   Moghetti P, 2000, J CLIN ENDOCR METAB, V85, P139, DOI 10.1210/jc.85.1.139
   Moran LJ, 2011, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD007506.pub3
   Moran LJ, 2009, FERTIL STERIL, V92, P1966, DOI 10.1016/j.fertnstert.2008.09.018
   Moran LJ, 2003, J CLIN ENDOCR METAB, V88, P812, DOI 10.1210/jc.2002-020815
   Morgante G, 2018, GYNECOL ENDOCRINOL, V34, P4, DOI 10.1080/09513590.2017.1370644
   Oakley BB, 2008, APPL ENVIRON MICROB, V74, P4898, DOI 10.1128/AEM.02884-07
   Paramsothy S, 2017, LANCET, V389, P1218, DOI 10.1016/S0140-6736(17)30182-4
   Parekh PJ, 2014, FRONT ENDOCRINOL, V5, DOI 10.3389/fendo.2014.00047
   Rial SA, 2016, NUTRIENTS, V8, DOI 10.3390/nu8050281
   Ridlon JM, 2013, J LIPID RES, V54, P2437, DOI 10.1194/jlr.M038869
   Sherman SB, 2018, GUT MICROBES, V9, P400, DOI 10.1080/19490976.2018.1441664
   Shi YY, 2012, NAT GENET, V44, P1020, DOI 10.1038/ng.2384
   Skubleny D, 2016, OBES SURG, V26, P169, DOI 10.1007/s11695-015-1902-5
   Sun LY, 2012, J PROTEOME RES, V11, P2937, DOI 10.1021/pr3000317
   Tan S, 2010, BMC MED GENET, V11, DOI 10.1186/1471-2350-11-12
   Tang T, 2003, COCHRANE DB SYST REV, DOI [10.1002/14651858.Cd003053, DOI 10.1002/14651858.CD003053, 10.1002/14651858.CD003053]
   Teede H, 2010, BMC MED, V8, DOI 10.1186/1741-7015-8-41
   Teles FR, 2012, J PERIODONTAL RES, V47, P95, DOI 10.1111/j.1600-0765.2011.01409.x
   Theriot CM, 2014, NAT COMMUN, V5, DOI 10.1038/ncomms4114
   Torres PJ, 2018, J CLIN ENDOCR METAB, V103, P1502, DOI 10.1210/jc.2017-02153
   Tremellen K, 2012, MED HYPOTHESES, V79, P104, DOI 10.1016/j.mehy.2012.04.016
   Turnbaugh PJ, 2009, SCI TRANSL MED, V1, DOI 10.1126/scitranslmed.3000322
   Umeda M, 1998, J PERIODONTOL, V69, P1111, DOI 10.1902/jop.1998.69.10.1111
   Vrieze A, 2012, GASTROENTEROLOGY, V143, P913, DOI 10.1053/j.gastro.2012.06.031
   Wei W, 2012, EUR J ENDOCRINOL, V166, P99, DOI 10.1530/EJE-11-0616
   Zhang DM, 2015, EUR J ENDOCRINOL, V172, DOI 10.1530/EJE-14-0589
   Zhang JW, 2012, AM J MED SCI, V343, P199, DOI 10.1097/MAJ.0b013e31823aace6
   Zheng Y, 2018, MICROB PATHOGENESIS, V121, P70, DOI 10.1016/j.micpath.2018.04.043
NR 64
TC 38
Z9 48
U1 2
U2 34
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-302X
J9 FRONT MICROBIOL
JI Front. Microbiol.
PD FEB 8
PY 2019
VL 10
AR 175
DI 10.3389/fmicb.2019.00175
PG 14
WC Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology
GA HK7VF
UT WOS:000458197100002
PM 30800111
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Vivo-Barrachina, L
   Rojas-Chacon, MJ
   Navarro-Salazar, R
   Belda-Sanchis, V
   Perez-Murillo, J
   Peiro-Puig, A
   Herran-Gonzalez, M
   Perez-Bermejo, M
AF Vivo-Barrachina, Lucia
   Rojas-Chacon, Maria Jose
   Navarro-Salazar, Rocio
   Belda-Sanchis, Victoria
   Perez-Murillo, Javier
   Peiro-Puig, Alicia
   Herran-Gonzalez, Mariana
   Perez-Bermejo, Marcelino
TI The Role of Natural Products on Diabetes Mellitus Treatment: A
   Systematic Review of Randomized Controlled Trials
SO PHARMACEUTICS
LA English
DT Review
DE diabetes mellitus; type 2; biological products; plants; antioxidants;
   therapeutics; natural products; phenols
ID TYPE-2; METFORMIN; EFFICACY; SAFETY
AB The present study was carried out to relate the role of natural products in the metabolism of an increasingly prevalent disease, type 2 diabetes mellitus. At present, in addition to the pharmacological resources, an attempt is being made to treat diabetes mellitus with natural products. We carried out a systematic review of studies focusing on the role of natural products on diabetes mellitus treatment. The bibliographic search was done through Medline (Pubmed) and Web of Science. From 193 records, the title and summary of each were examined according to the criteria and whether they met the selection criteria. A total of 15 articles were included; after reviewing the literature, it is apparent that the concept of natural products is ambiguous as no clear boundary has been established between what is natural and what is synthetic, therefore we feel that a more explicit definition of the concept of "natural product" is needed. Gut microbiota is a promising therapeutic target in the treatment of diabetes. Therefore, it would be necessary to work on the relationship between the microbiome and the benefits in the treatment of diabetes mellitus. Treatment based solely on these natural products is not currently recommended as more studies are needed.
C1 [Vivo-Barrachina, Lucia; Rojas-Chacon, Maria Jose; Navarro-Salazar, Rocio; Belda-Sanchis, Victoria; Perez-Murillo, Javier; Peiro-Puig, Alicia; Herran-Gonzalez, Mariana] Catholic Univ Valencia San Vicente Martir, Sch Med & Hlth Sci, Dept Nutr, C Quevedo 2, Valencia 46001, Spain.
   [Perez-Bermejo, Marcelino] Catholic Univ Valencia San Vicente Martir, Sch Med & Hlth Sci, SONEV Res Grp, C Quevedo 2, Valencia 46001, Spain.
C3 Universidad Catolica de Valencia San Vicente Martir; Universidad
   Catolica de Valencia San Vicente Martir
RP Perez-Bermejo, M (通讯作者)，Catholic Univ Valencia San Vicente Martir, Sch Med & Hlth Sci, SONEV Res Grp, C Quevedo 2, Valencia 46001, Spain.
EM luviba@mail.ucv.es; mariarojaas96@mail.ucv.es;
   rocioinmaculada.navarro@mail.ucv.es; victoria.belda@mail.ucv.es;
   javierperezmurillo@mail.ucv.es; alicia.peiro@mail.ucv.es;
   mariana.herran@mail.ucv.es; marcelino.perez@ucv.es
RI Pérez-Bermejo, Marcelino/L-7161-2018
OI Pérez-Bermejo, Marcelino/0000-0002-5027-4785
CR Abu-Odeh AM, 2021, MOLECULES, V26, DOI 10.3390/molecules26030742
   Aziz TA, 2018, DRUG DES DEV THER, V12, P735, DOI 10.2147/DDDT.S157113
   Bedekar A, 2010, ADV APPL MICROBIOL, V71, P21, DOI 10.1016/S0065-2164(10)71002-9
   Briggs Joanna, 2017, JOANNA BRIGGS I CRIT
   Foretz M, 2014, CELL METAB, V20, P953, DOI 10.1016/j.cmet.2014.09.018
   Funamoto M, 2019, J DIABETES RES, V2019, DOI 10.1155/2019/8208237
   Garg SK, 2020, DIABETES TECHNOL THE, V22, P85, DOI 10.1089/dia.2019.0382
   Gori M, 1998, DIABETES EDUCATOR, V24, P201, DOI 10.1177/014572179802400210
   Hsieh MC, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-35014-1
   Hwang HG, 2016, J MICROBIOL BIOTECHN, V26, P1781, DOI 10.4014/jmb.1602.02053
   Kaneto Hideaki, 2015, Nihon Rinsho, V73, P2003
   Khalid M, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22168590
   Khalili N, 2017, J EVID-BASED INTEGR, V22, P603, DOI 10.1177/2156587217696929
   Lambert C, 2018, NUTRIENTS, V10, DOI 10.3390/nu10030271
   Ros JL, 2015, PLANTA MED, V81, P975, DOI 10.1055/s-0035-1546131
   Mendoza Romo Miguel Angel, 2017, Rev Panam Salud Publica, V41, pe103, DOI 10.26633/RPSP.2017.103
   Merkevicius K, 2021, MEDICINA-LITHUANIA, V57, DOI 10.3390/medicina57101084
   Moher D, 2010, INT J SURG, V8, P336, DOI [10.1136/bmj.b2535, 10.1016/j.ijsu.2010.02.007, 10.1016/j.ijsu.2010.07.299, 10.1186/s13643-015-0087-2]
   Moszak M, 2020, NUTRIENTS, V12, DOI 10.3390/nu12041096
   Odeyemi S, 2018, MOLECULES, V23, DOI 10.3390/molecules23112759
   Patle D, 2021, CURR DIABETES REV, V17, P186, DOI 10.2174/1573399816666200408090058
   Pepato MT, 2002, J ETHNOPHARMACOL, V81, P191, DOI 10.1016/S0378-8741(02)00075-2
   Pereira ASP, 2019, MOLECULES, V24, DOI 10.3390/molecules24224030
   Poblete-Aro C, 2018, REV MED CHILE, V146, P362, DOI 10.4067/s0034-98872018000300362
   Qin Q, 2021, FRONT CELL INFECT MI, V11, DOI 10.3389/fcimb.2021.719542
   Quinn L, 2001, NURS CLIN N AM, V36, P175
   Rabiei K, 2018, BMC COMPLEM ALTERN M, V18, DOI 10.1186/s12906-018-2268-8
   Rashad H, 2017, PHARM BIOL, V55, DOI 10.1080/13880209.2017.1354388
   Salehi B, 2019, BIOMOLECULES, V9, DOI 10.3390/biom9100551
   Shin NR, 2020, AM J PHYSIOL-ENDOC M, V318, pE52, DOI 10.1152/ajpendo.00221.2019
   Shokoohi R, 2017, J EVID-BASED INTEGR, V22, P798, DOI 10.1177/2156587217737683
   Solverson PM, 2019, NUTRIENTS, V11, DOI 10.3390/nu11122876
   Talaei B, 2017, NUTRIENTS, V9, DOI 10.3390/nu9090991
   Thazhath SS, 2016, AM J CLIN NUTR, V103, P66, DOI 10.3945/ajcn.115.117440
   Thota RN, 2019, LIPIDS HEALTH DIS, V18, DOI 10.1186/s12944-019-0967-x
   Tong XL, 2018, MBIO, V9, DOI 10.1128/mBio.02392-17
   Xu LN, 2018, PHARMACOL RES, V130, P451, DOI 10.1016/j.phrs.2018.01.015
   Yeung AWK, 2021, NAT PROD RES, V35, P5813, DOI 10.1080/14786419.2020.1821019
   Zakerkish M, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-43838-8
NR 39
TC 4
Z9 4
U1 7
U2 36
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1999-4923
J9 PHARMACEUTICS
JI Pharmaceutics
PD JAN
PY 2022
VL 14
IS 1
AR 101
DI 10.3390/pharmaceutics14010101
PG 12
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA YN5QE
UT WOS:000747312200001
PM 35056997
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Gu, YY
   Wang, XK
   Li, JH
   Zhang, YF
   Zhong, HZ
   Liu, RX
   Zhang, DY
   Feng, Q
   Xie, XY
   Hong, J
   Ren, HH
   Liu, W
   Ma, J
   Su, Q
   Zhang, HM
   Yang, JL
   Wang, XL
   Zhao, XJ
   Gu, WQ
   Bi, YF
   Peng, YD
   Xu, XQ
   Xia, HH
   Li, F
   Xu, X
   Yang, HM
   Xu, GW
   Madsen, L
   Kristiansen, K
   Ning, G
   Wang, WQ
AF Gu, Yanyun
   Wang, Xiaokai
   Li, Junhua
   Zhang, Yifei
   Zhong, Huanzi
   Liu, Ruixin
   Zhang, Dongya
   Feng, Qiang
   Xie, Xiaoyan
   Hong, Jie
   Ren, Huahui
   Liu, Wei
   Ma, Jing
   Su, Qing
   Zhang, Hongmei
   Yang, Jialin
   Wang, Xiaoling
   Zhao, Xinjie
   Gu, Weiqiong
   Bi, Yufang
   Peng, Yongde
   Xu, Xiaoqiang
   Xia, Huihua
   Li, Fang
   Xu, Xun
   Yang, Huanming
   Xu, Guowang
   Madsen, Lise
   Kristiansen, Karsten
   Ning, Guang
   Wang, Weiqing
TI Analyses of gut microbiota and plasma bile acids enable stratification
   of patients for antidiabetic treatment
SO NATURE COMMUNICATIONS
LA English
DT Article
ID FARNESOID-X-RECEPTOR; INSULIN-RESISTANCE; BARIATRIC SURGERY;
   RANDOMIZED-TRIAL; SERUM METABOLOME; METFORMIN; GLUCOSE; ENTEROTYPES;
   METAGENOME; ACARBOSE
AB Antidiabetic medication may modulate the gut microbiota and thereby alter plasma and faecal bile acid (BA) composition, which may improve metabolic health. Here we show that treatment with Acarbose, but not Glipizide, increases the ratio between primary BAs and secondary BAs and plasma levels of unconjugated BAs in treatment-naive type 2 diabetes (T2D) patients, which may beneficially affect metabolism. Acarbose increases the relative abundances of Lactobacillus and Bifidobacterium in the gut microbiota and depletes Bacteroides, thereby changing the relative abundance of microbial genes involved in BA metabolism. Treatment outcomes of Acarbose are dependent on gut microbiota compositions prior to treatment. Compared to patients with a gut microbiota dominated by Prevotella, those with a high abundance of Bacteroides exhibit more changes in plasma BAs and greater improvement in metabolic parameters after Acarbose treatment. Our work highlights the potential for stratification of T2D patients based on their gut microbiota prior to treatment.
C1 [Gu, Yanyun; Zhang, Yifei; Liu, Ruixin; Xie, Xiaoyan; Hong, Jie; Gu, Weiqiong; Bi, Yufang; Ning, Guang; Wang, Weiqing] Shanghai Jiao Tong Univ, Shanghai Natl Res Ctr Endocrine & Metab Dis, Ruijin Hosp,State Key Lab Med Genom, Shanghai Inst Endocrine & Metab Dis,Sch Med, Shanghai 200025, Peoples R China.
   [Wang, Xiaokai; Li, Junhua; Zhong, Huanzi; Zhang, Dongya; Feng, Qiang; Ren, Huahui; Xu, Xiaoqiang; Xia, Huihua; Li, Fang; Xu, Xun; Yang, Huanming; Madsen, Lise; Kristiansen, Karsten] China Natl GeneBank Shenzhen, BGI Shenzhen, Shenzhen 518083, Peoples R China.
   [Wang, Xiaokai; Xu, Xiaoqiang; Madsen, Lise] Univ Chinese Acad Sci, BGI Educ Ctr, Shenzhen 518083, Peoples R China.
   [Li, Junhua; Ren, Huahui; Xia, Huihua; Li, Fang] BGI Shenzhen, Shenzhen Key Lab Human Commensal Microorganisms &, Shenzhen 518083, Peoples R China.
   [Zhong, Huanzi; Kristiansen, Karsten] Univ Copenhagen, Dept Biol, Lab Genom & Mol Biomed, DK-2100 Copenhagen, Denmark.
   [Ren, Huahui; Li, Fang] BGI Shenzhen, Shenzhen Engn Lab Detect & Intervent Human Intest, Shenzhen 518083, Peoples R China.
   [Liu, Wei; Ma, Jing] Shanghai Jiao Tong Univ, Med Sch, Renji Hosp, Shanghai 200127, Peoples R China.
   [Su, Qing; Zhang, Hongmei] Shanghai Jiao Tong Univ, Med Sch, Xinhua Hosp, Shanghai 200092, Peoples R China.
   [Yang, Jialin] Fudan Univ, Med Sch, MinHang Cent Hosp, Shanghai 201100, Peoples R China.
   [Wang, Xiaoling; Zhao, Xinjie; Xu, Guowang] Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116011, Peoples R China.
   [Peng, Yongde] Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Shanghai 200080, Peoples R China.
   [Yang, Huanming] James D Watson Inst Genome Sci, Hangzhou 310008, Zhejiang, Peoples R China.
   [Madsen, Lise] Natl Inst Nutr & Seafood Res NIFES, N-5817 Bergen, Norway.
C3 Chinese Academy of Sciences; Shanghai Jiao Tong University; Beijing
   Genomics Institute (BGI); Chinese Academy of Sciences; University of
   Chinese Academy of Sciences, CAS; Beijing Genomics Institute (BGI);
   University of Copenhagen; Beijing Genomics Institute (BGI); Shanghai
   Jiao Tong University; Shanghai Jiao Tong University; Fudan University;
   Chinese Academy of Sciences; Dalian Institute of Chemical Physics, CAS;
   Shanghai Jiao Tong University
RP Ning, G; Wang, WQ (通讯作者)，Shanghai Jiao Tong Univ, Shanghai Natl Res Ctr Endocrine & Metab Dis, Ruijin Hosp,State Key Lab Med Genom, Shanghai Inst Endocrine & Metab Dis,Sch Med, Shanghai 200025, Peoples R China.; Kristiansen, K (通讯作者)，China Natl GeneBank Shenzhen, BGI Shenzhen, Shenzhen 518083, Peoples R China.; Kristiansen, K (通讯作者)，Univ Copenhagen, Dept Biol, Lab Genom & Mol Biomed, DK-2100 Copenhagen, Denmark.
EM kk@bio.ku.dk; gning@sibs.ac.cn; wqingw61@163.com
RI wang, xiao/HZI-9156-2023; Xu, Guowang/L-6910-2014; Zhang,
   Yifei/GRO-3001-2022; Xu, Xun/AAI-6763-2020; Madsen, Lise/C-6246-2012;
   LI, Junhua/AAG-3919-2019; Zhong, Huanzi/ISA-4702-2023
OI Xu, Guowang/0000-0003-4298-3554; Xu, Xun/0000-0002-5338-5173; Madsen,
   Lise/0000-0003-4468-1947; LI, Junhua/0000-0001-6784-1873; wang,
   xiaokai/0000-0002-6055-0325; Zhong, Huanzi/0000-0001-9512-1750
FU National Basic Research Program of China [2015CB5536003]; Bayer
   HealthCare; National Nature Science Foundation of China [81621061,
   81670761, 81370963]; National International Science Cooperation
   Foundation [2015DFA30560]; Shanghai Rising-Star Program [17QA1403300];
   Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant
   [20161411]; Shanghai Municipal Education Commission; Shanghai Education
   Development Foundation [14SG17]; Three year Action Plan and Public
   Health, Phase IV, Shanghai [15GWZK0802]; National Key R&D program of
   China [2016YFC1305601]; Shenzhen Municipal Government of China
   [JSGG20160229172752028, CXB201108250098A]
FX We thank Mr. Yixin Wu, Mr. Wenzhong Zhou and Ms. Qun Zhang of the
   Central Laboratory, Shanghai Institute of Endocrine and Metabolic
   Diseases, for help with analysing HbA1c levels. We also thank Dr. H.
   Bjorn Nielsen and Dr. Susanne Brix of the Technical University of
   Denmark for their valuable inputs and discussions. We also thank
   Shanghai ProfLeader Biotech Co., Ltd. for the assistance with the
   analysis of faecal BAs. This work was supported by grants from the
   National Basic Research Program of China (2015CB5536003), Bayer
   HealthCare, the National Nature Science Foundation of China (81621061,
   81670761, 81370963), National International Science Cooperation
   Foundation (no. 2015DFA30560), Shanghai Rising-Star Program
   (17QA1403300), Shanghai Municipal Education Commission-Gaofeng Clinical
   Medicine Grant (No. 20161411), Shanghai Municipal Education Commission
   and Shanghai Education Development Foundation (No. 14SG17), Three year
   Action Plan and Public Health, Phase IV, Shanghai (No. 15GWZK0802),
   National Key R&D program of China (2016YFC1305601) and Shenzhen
   Municipal Government of China (JSGG20160229172752028 and
   CXB201108250098A).
CR [Anonymous], 2012, DIABETES CARE S1, V35, pS4, DOI DOI 10.2337/DC12-S004
   Aron-Wisnewsky J, 2012, NAT REV GASTRO HEPAT, V9, P590, DOI 10.1038/nrgastro.2012.161
   Arumugam M, 2011, NATURE, V473, P174, DOI 10.1038/nature09944
   Backhed F, 2015, CELL HOST MICROBE, V17, P690, DOI [10.1016/j.chom.2015.04.004, 10.1016/j.chom.2015.05.012]
   Bedogni G, 2006, BMC GASTROENTEROL, V6, DOI 10.1186/1471-230X-6-33
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   Chiasson JL, 2002, LANCET, V359, P2072, DOI 10.1016/S0140-6736(02)08905-5
   De-Souza DA, 2005, CRIT CARE MED, V33, P1125, DOI 10.1097/01.CCM.0000162680.52397.97
   Degirolamo C, 2016, NAT REV DRUG DISCOV, V15, P51, DOI 10.1038/nrd.2015.9
   Degirolamo C, 2014, CELL REP, V7, P12, DOI 10.1016/j.celrep.2014.02.032
   DEITCH EA, 1990, ARCH SURG-CHICAGO, V125, P403
   Deng YY, 2015, J DIABETES, V7, P820, DOI 10.1111/1753-0407.12245
   Ferrannini E, 2015, DIABETES, V64, P3377, DOI 10.2337/db15-0214
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Gabir MM, 2000, DIABETES CARE, V23, P1108, DOI 10.2337/diacare.23.8.1108
   Haeusler RA, 2013, DIABETES, V62, P4184, DOI 10.2337/db13-0639
   Jiang CT, 2015, J CLIN INVEST, V125, P386, DOI 10.1172/JCI76738
   John C, 2014, J CHROMATOGR A, V1371, P184, DOI 10.1016/j.chroma.2014.10.064
   Joyce SA, 2016, ANNU REV FOOD SCI T, V7, P313, DOI 10.1146/annurev-food-041715-033159
   Joyce SA, 2014, P NATL ACAD SCI USA, V111, P7421, DOI 10.1073/pnas.1323599111
   Kahn SE, 2014, LANCET, V383, P1068, DOI 10.1016/S0140-6736(13)62154-6
   Kanehisa M, 2016, J MOL BIOL, V428, P726, DOI 10.1016/j.jmb.2015.11.006
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Knights D, 2014, CELL HOST MICROBE, V16, P433, DOI 10.1016/j.chom.2014.09.013
   Ko SH, 2011, DIABETES METAB J, V35, P431, DOI 10.4093/dmj.2011.35.5.431
   Le Chatelier E, 2013, NATURE, V500, P541, DOI 10.1038/nature12506
   Lebovitz HE, 1997, ENDOCRIN METAB CLIN, V26, P539, DOI 10.1016/S0889-8529(05)70266-8
   Li JH, 2014, NAT BIOTECHNOL, V32, P834, DOI 10.1038/nbt.2942
   Li TG, 2014, PHARMACOL REV, V66, P948, DOI 10.1124/pr.113.008201
   Lien F, 2014, J CLIN INVEST, V124, P1037, DOI 10.1172/JCI68815
   Liou AP, 2013, SCI TRANSL MED, V5, DOI 10.1126/scitranslmed.3005687
   Liu RX, 2017, NAT MED, V23, P859, DOI 10.1038/nm.4358
   Lynch SV, 2016, NEW ENGL J MED, V375, P2369, DOI 10.1056/NEJMra1600266
   Ma K, 2006, J CLIN INVEST, V116, P1102, DOI 10.1172/JCI25604
   Manichanh C, 2012, NAT REV GASTRO HEPAT, V9, P599, DOI 10.1038/nrgastro.2012.152
   Mingrone G, 2012, NEW ENGL J MED, V366, P1577, DOI 10.1056/NEJMoa1200111
   Pedersen HK, 2016, NATURE, V535, P376, DOI 10.1038/nature18646
   Pussinen PJ, 2011, DIABETES CARE, V34, P392, DOI 10.2337/dc10-1676
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Rey FE, 2013, P NATL ACAD SCI USA, V110, P13582, DOI 10.1073/pnas.1312524110
   Ridlon JM, 2014, CURR OPIN GASTROEN, V30, P332, DOI 10.1097/MOG.0000000000000057
   Ridlon JM, 2006, J LIPID RES, V47, P241, DOI 10.1194/jlr.R500013-JLR200
   Ryan KK, 2014, NATURE, V509, P183, DOI 10.1038/nature13135
   Shapiro H, 2017, J DIABETES, V9, P226, DOI 10.1111/1753-0407.12501
   Song KH, 2009, HEPATOLOGY, V49, P297, DOI 10.1002/hep.22627
   Sunagawa S, 2013, NAT METHODS, V10, P1196, DOI [10.1038/nmeth.2693, 10.1038/NMETH.2693]
   TAKAHASHI T, 1994, J DAIRY SCI, V77, P3275, DOI 10.3168/jds.S0022-0302(94)77268-4
   TANNOCK GW, 1989, APPL ENVIRON MICROB, V55, P1848, DOI 10.1128/AEM.55.7.1848-1851.1989
   Vetizou M, 2015, SCIENCE, V350, P1079, DOI 10.1126/science.aad1329
   Wahlstrom A, 2016, CELL METAB, V24, P41, DOI 10.1016/j.cmet.2016.05.005
   Weng JP, 2016, DIABETES-METAB RES, V32, P442, DOI 10.1002/dmrr.2827
   Wewalka M, 2014, J CLIN ENDOCR METAB, V99, P1442, DOI 10.1210/jc.2013-3367
   Wu GD, 2011, SCIENCE, V334, P105, DOI 10.1126/science.1208344
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Xu Y, 2016, J DIABETES, V8, P378, DOI 10.1111/1753-0407.12305
   Yang WY, 2014, LANCET DIABETES ENDO, V2, P46, DOI 10.1016/S2213-8587(13)70021-4
   Zhang JP, 2016, J DIABETES, V8, P559, DOI 10.1111/1753-0407.12337
   Zhang X, 2015, NAT MED, V21, P895, DOI 10.1038/nm.3914
   Zhang YQ, 2006, P NATL ACAD SCI USA, V103, P1006, DOI 10.1073/pnas.0506982103
NR 59
TC 217
Z9 252
U1 19
U2 164
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2041-1723
J9 NAT COMMUN
JI Nat. Commun.
PD NOV 27
PY 2017
VL 8
AR 1785
DI 10.1038/s41467-017-01682-2
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA FN8RQ
UT WOS:000416293600001
PM 29176714
OA Green Published, gold
HC Y
HP N
DA 2023-06-08
ER

PT J
AU Fang, XY
   Wu, HR
   Wang, XM
   Lian, FM
   Li, M
   Miao, RY
   Wei, JH
   Tian, JX
AF Fang, Xinyi
   Wu, Haoran
   Wang, Xinmiao
   Lian, Fengmei
   Li, Min
   Miao, Runyu
   Wei, Jiahua
   Tian, Jiaxing
TI Modulation of Gut Microbiota and Metabolites by Berberine in Treating
   Mice With Disturbances in Glucose and Lipid Metabolism
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE glucose and lipid metabolism disturbances; berberine; gut microbiota;
   metagenomics; metabolomics
ID SERUM METABOLOME; OBESITY; METFORMIN; ACIDS
AB Introduction: Glucose and lipid metabolism disturbances has become the third major disease after cancer and cardio-cerebrovascular diseases. Emerging evidence shows that berberine can effectively intervene glucose and lipid metabolism disturbances, but the underlying mechanisms of this remain unclear. To investigate this issue, we performed metagenomic and metabolomic analysis in a group of normal mice (the NC group), mice with disturbances in glucose and lipid metabolism (the MC group) and mice with disturbances in glucose and lipid metabolism after berberine intervention (the BER group).Result: Firstly, analysis of the clinical indicators revealed that berberine significantly improved the blood glucose and blood lipid of the host. The fasting blood glucose level decreased by approximately 30% in the BER group after 8 weeks and the oral glucose tolerance test showed that the blood glucose level of the BER group was lower than that of the MC group at any time. Besides, berberine significantly reduced body weight, total plasma cholesterol and triglyceride. Secondly, compared to the NC group, we found dramatically decreased microbial richness and diversity in the MC group and BER group. Thirdly, LDA effect size suggested that berberine significantly altered the overall gut microbiota structure and enriched many bacteria, including Akkermansia (p < 0.01), Eubacterium (p < 0.01) and Ruminococcus (p < 0.01). Fourthly, the metabolomic analysis suggested that there were significant differences in the metabolomics signature of each group. For example, isoleucine (p < 0.01), phenylalanine (p < 0.05), and arbutin (p < 0.05) significantly increased in the MC group, and berberine intervention significantly reduced them. The arbutin content in the BER group was even lower than that in the NC group. Fifthly, by combined analysis of metagenomics and metabolomics, we observed that there were significantly negative correlations between the reduced faecal metabolites (e.g., arbutin) in the BER group and the enriched gut microbiota (e.g., Eubacterium and Ruminococcus) (p < 0.05). Finally, the correlation analysis between gut microbiota and clinical indices indicated that the bacteria (e.g., Eubacterium) enriched in the BER group were negatively associated with the above-mentioned clinical indices (p < 0.05).Conclusion: Overall, our results describe that the changes of gut microbiota and metabolites are associated with berberine improving glucose and lipid metabolism disturbances.
C1 [Fang, Xinyi; Li, Min; Tian, Jiaxing] China Acad Chinese Med Sci, Guanganmen Hosp, Dept Endocrinol, Beijing, Peoples R China.
   [Fang, Xinyi] Beijing Univ Chinese Med, Grad Coll, Beijing, Peoples R China.
   Changchun Univ Chinese Med, Grad Coll, Changchun, Peoples R China.
C3 China Academy of Chinese Medical Sciences; Guang'anmen Hospital, CACMS;
   Beijing University of Chinese Medicine; Changchun University of Chinese
   Medicine
RP Tian, JX (通讯作者)，China Acad Chinese Med Sci, Guanganmen Hosp, Dept Endocrinol, Beijing, Peoples R China.
EM tina_yai@126.com
FU National Natural Science Foundation of China [81904187]; Capital Health
   Development Research Project [CD2020-4-4155]; CACMS Outstanding Young
   Scientific and Technological Talents Program [ZZ13-YQ-026]; Scientific
   and technological innovation project of China Academy of Chinese Medical
   Sciences [CI 2021A01601]; Innovation Team and Talents Cultivation
   Program of National Administration of Traditional Chinese Medicine
   [ZYYCXTD-D-202001]; Open Project of National Facility for Translational
   Medicine [TMSK-2021-407]
FX This work was supported by National Natural Science Foundation of China
   (81904187), Capital Health Development Research Project (CD2020-4-4155),
   CACMS Outstanding Young Scientific and Technological Talents Program
   (ZZ13-YQ-026), Scientific and technological innovation project of China
   Academy of Chinese Medical Sciences (CI 2021A01601), Innovation Team and
   Talents Cultivation Program of National Administration of Traditional
   Chinese Medicine (ZYYCXTD-D-202001), Open Project of National Facility
   for Translational Medicine (TMSK-2021-407).
CR Agus A, 2021, GUT, V70, P1174, DOI 10.1136/gutjnl-2020-323071
   Aye ILMH, 2015, P NATL ACAD SCI USA, V112, P12858, DOI 10.1073/pnas.1515484112
   Bisanz JE, 2019, CELL HOST MICROBE, V26, P265, DOI 10.1016/j.chom.2019.06.013
   Bodogai M, 2018, SCI TRANSL MED, V10, DOI 10.1126/scitranslmed.aat4271
   Dai ZL, 2011, FRONT BIOSCI-LANDMRK, V16, P1768, DOI 10.2741/3820
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Fan Y, 2021, NAT REV MICROBIOL, V19, P55, DOI 10.1038/s41579-020-0433-9
   Fang Y, 2021, PHARMACOL RES, V165, DOI 10.1016/j.phrs.2021.105439
   Fiamoncini J, 2018, FASEB J, V32, P5447, DOI 10.1096/fj.201800330R
   Foley KP, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-018-07146-5
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Gannon NP, 2018, MOL NUTR FOOD RES, V62, DOI 10.1002/mnfr.201700756
   Gurung M, 2020, EBIOMEDICINE, V51, DOI 10.1016/j.ebiom.2019.11.051
   Han YB, 2020, INT IMMUNOPHARMACOL, V86, DOI 10.1016/j.intimp.2020.106741
   Hartstra AV, 2015, DIABETES CARE, V38, P159, DOI 10.2337/dc14-0769
   Kassambara A, 2020, GGPUBRGGPLOT2 BASED
   Lee G, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-18754-5
   Li LY, 2020, GUT MICROBES, V11, P1348, DOI 10.1080/19490976.2020.1755413
   Li YY, 2019, MOL NUTR FOOD RES, V63, DOI 10.1002/mnfr.201801219
   Liu RX, 2017, NAT MED, V23, P859, DOI 10.1038/nm.4358
   Louis P, 2014, NAT REV MICROBIOL, V12, P661, DOI 10.1038/nrmicro3344
   Maifeld A, 2021, NAT COMMUN, V12, DOI 10.1038/s41467-021-22097-0
   Moreno-Navarrete JM, 2018, MOL NUTR FOOD RES, V62, DOI 10.1002/mnfr.201700721
   Maruvada P, 2017, CELL HOST MICROBE, V22, P589, DOI 10.1016/j.chom.2017.10.005
   Min Y, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-10440-5
   Mukherjee A, 2020, GUT MICROBES, V12, DOI 10.1080/19490976.2020.1802866
   Newman N.K., 2020, BIORXIV, DOI [10.1101/2020.12.08.416487, DOI 10.1101/2020.12.08.416487]
   Nie QX, 2019, CRIT REV FOOD SCI, V59, P848, DOI 10.1080/10408398.2018.1536646
   Org E, 2017, GENOME BIOL, V18, DOI 10.1186/s13059-017-1194-2
   Pedersen HK, 2016, NATURE, V535, P376, DOI 10.1038/nature18646
   Rodrigues RR, 2021, NAT COMMUN, V12, DOI 10.1038/s41467-020-20313-x
   Shapiro H, 2018, J EXP MED, V215, P383, DOI 10.1084/jem.20171965
   Son JS, 2022, EBIOMEDICINE, V76, DOI 10.1016/j.ebiom.2022.103842
   Son JS, 2019, J PHYSIOL-LONDON, V597, P3333, DOI 10.1113/JP277698
   Song XF, 2019, GENOM PROTEOM BIOINF, V17, P64, DOI 10.1016/j.gpb.2019.03.001
   Stewart CJ, 2018, NATURE, V562, P583, DOI 10.1038/s41586-018-0617-x
   Surowiec I, 2019, METABOLOMICS, V15, DOI 10.1007/s11306-019-1484-7
   Thioulouse J., 2018, MULTIVARIATE ANAL EC, DOI [10.1007/978-1-4939-8850-1, DOI 10.1007/978-1-4939-8850-1]
   Tillin T, 2015, DIABETOLOGIA, V58, P968, DOI 10.1007/s00125-015-3517-8
   Vrieze A, 2012, GASTROENTEROLOGY, V143, P913, DOI 10.1053/j.gastro.2012.06.031
   Wang L, 2021, FRONT CELL INFECT MI, V11, DOI 10.3389/fcimb.2021.598672
   Wang XY, 2019, CELL RES, V29, P787, DOI 10.1038/s41422-019-0216-x
   Wickham H, 2016, USE R, DOI DOI 10.1007/978-0-387-98141-3_1
   Wopereis H, 2018, J ALLERGY CLIN IMMUN, V141, P1334, DOI 10.1016/j.jaci.2017.05.054
   Wu JS, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.02081
   Wu JY, 2021, PROTEIN CELL, V12, P360, DOI 10.1007/s13238-020-00814-7
   Xu JH, 2017, MOL MED REP, V15, P2765, DOI 10.3892/mmr.2017.6321
   Xu XZ, 2020, GENOM PROTEOM BIOINF, V18, P721, DOI [10.1016/j.gpb.2019.09.0071672-0229, 10.1016/j.gpb.2019.09.007]
   Yang QY, 2016, CELL METAB, V24, P542, DOI 10.1016/j.cmet.2016.08.010
   Yin J, 2002, METABOLISM, V51, P1439, DOI 10.1053/meta.2002.34715
   Yin J, 2012, ACTA PHARM SIN B, V2, P327, DOI 10.1016/j.apsb.2012.06.003
   Yoon HS, 2021, NAT MICROBIOL, V6, P563, DOI 10.1038/s41564-021-00880-5
   Zhang CH, 2015, EBIOMEDICINE, V2, P968, DOI 10.1016/j.ebiom.2015.07.007
   Zhang X, 2015, SCI REP-UK, V5, DOI 10.1038/srep14405
   Zhang X, 2012, PLOS ONE, V7, DOI [10.1371/journal.pone.0042529, 10.1371/journal.pone.0035700]
   Zhu XT, 2018, APPL MICROBIOL BIOT, V102, P8145, DOI 10.1007/s00253-018-9241-9
NR 56
TC 3
Z9 3
U1 5
U2 14
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD JUN 3
PY 2022
VL 13
AR 870407
DI 10.3389/fphar.2022.870407
PG 15
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 2F3TK
UT WOS:000812834700001
PM 35721198
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Barone, M
   D'Amico, F
   Rampelli, S
   Brigidi, P
   Turroni, S
AF Barone, Monica
   D'Amico, Federica
   Rampelli, Simone
   Brigidi, Patrizia
   Turroni, Silvia
TI Age-related diseases, therapies and gut microbiome: A new frontier for
   healthy aging
SO MECHANISMS OF AGEING AND DEVELOPMENT
LA English
DT Article
DE Aging; Gut microbiome; Age -related diseases; Anti -age therapies;
   Microbiome-based therapies
ID PUMP INHIBITORS ALTER; CHAIN FATTY-ACIDS; RESISTANT MALTODEXTRIN;
   CELLULAR SENESCENCE; PARKINSONS-DISEASE; SENOLYTIC AGENT;
   BLOOD-PRESSURE; LIFE-SPAN; METFORMIN; HYPERTENSION
AB The gut microbiome is undoubtedly a key modulator of human health, which can promote or impair homeostasis throughout life. This is even more relevant in old age, when there is a gradual loss of function in multiple organ systems, related to growth, metabolism, and immunity. Several studies have described changes in the gut microbiome across age groups up to the extreme limits of lifespan, including maladaptations that occur in the context of age-related conditions, such as frailty, neurodegenerative diseases, and cardiometabolic diseases. The gut microbiome can also interact bi-directionally with anti-age-related disease therapies, being affected and in turn influencing their efficacy. In this framework, the development of integrated microbiome-based intervention strategies, aimed at favoring a eubiotic configuration and trajectory, could therefore represent an innovative approach for the promotion of healthy aging and the achievement of longevity.
C1 [Barone, Monica; D'Amico, Federica; Brigidi, Patrizia] Univ Bologna, Dept Med & Surg Sci, Microbi Unit, I-40138 Bologna, Italy.
   [Barone, Monica; D'Amico, Federica; Rampelli, Simone; Turroni, Silvia] Univ Bologna, Dept Pharm & Biotechnol, Unit Microbiome Sci & Biotechnol, I-40126 Bologna, Italy.
C3 University of Bologna; University of Bologna
RP Turroni, S (通讯作者)，Univ Bologna, Dept Pharm & Biotechnol, Unit Microbiome Sci & Biotechnol, I-40126 Bologna, Italy.
EM monica.barone@unibo.it; federica.damico8@unibo.it;
   simone.rampelli@unibo.it; patrizia.brigidi@unibo.it;
   silvia.turroni@unibo.it
RI D'Amico, Federica/AAA-7556-2019; Rampelli, Simone/K-5675-2016; Barone,
   Monica/AAA-3514-2019
OI D'Amico, Federica/0000-0002-2136-9558; Rampelli,
   Simone/0000-0002-5655-6695; Barone, Monica/0000-0001-5229-570X
CR Adak T, 2018, REGUL TOXICOL PHARM, V92, P324, DOI 10.1016/j.yrtph.2017.12.023
   Adnan S, 2017, PHYSIOL GENOMICS, V49, P96, DOI 10.1152/physiolgenomics.00081.2016
   Akbari E, 2016, FRONT AGING NEUROSCI, V8, DOI 10.3389/fnagi.2016.00256
   Apelo SIA, 2016, J GERONTOL A-BIOL, V71, P841, DOI 10.1093/gerona/glw090
   Armstrong MJ, 2020, JAMA-J AM MED ASSOC, V323, P548, DOI 10.1001/jama.2019.22360
   Ashburn TT, 2004, NAT REV DRUG DISCOV, V3, P673, DOI 10.1038/nrd1468
   Augustine JJ, 2007, DRUGS, V67, P369, DOI 10.2165/00003495-200767030-00004
   Baer DJ, 2014, J NUTR, V144, P1023, DOI 10.3945/jn.113.185298
   Bailey CJ, 2017, DIABETOLOGIA, V60, P1566, DOI 10.1007/s00125-017-4318-z
   Baker DJ, 2016, NATURE, V530, P184, DOI 10.1038/nature16932
   Baker DJ, 2011, NATURE, V479, P232, DOI 10.1038/nature10600
   Balasuriya N, 2012, FOOD CHEM, V135, P2320, DOI 10.1016/j.foodchem.2012.07.023
   Barichella M, 2016, NEUROLOGY, V87, P1274, DOI 10.1212/WNL.0000000000003127
   Barone M, 2021, WORLD J GASTROENTERO, V27, P7041, DOI 10.3748/wjg.v27.i41.7041
   Barone M, 2021, J MED CHEM, V64, P17277, DOI 10.1021/acs.jmedchem.1c01333
   Baumann-Dudenhoeffer AM, 2018, NAT MED, V24, P1822, DOI 10.1038/s41591-018-0216-2
   Bechshoft RL, 2016, TRIALS, V17, DOI 10.1186/s13063-016-1512-0
   Bellikci-Koyu E, 2019, NUTRIENTS, V11, DOI 10.3390/nu11092089
   Benavente-Garcia O, 2008, J AGR FOOD CHEM, V56, P6185, DOI 10.1021/jf8006568
   Benetos A, 2019, CIRC RES, V124, P1045, DOI 10.1161/CIRCRESAHA.118.313236
   de Jesus BB, 2011, AGING CELL, V10, P604, DOI 10.1111/j.1474-9726.2011.00700.x
   Biagi E, 2017, MECH AGEING DEV, V165, P180, DOI 10.1016/j.mad.2016.12.013
   Biagi E, 2016, CURR BIOL, V26, P1480, DOI 10.1016/j.cub.2016.04.016
   Biagi E, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0112023
   Bitto A, 2016, ELIFE, V5, DOI 10.7554/eLife.16351
   Bjedov I, 2020, GENES-BASEL, V11, DOI 10.3390/genes11091043
   Blagosklonny MV, 2012, AM J PATHOL, V181, P1142, DOI 10.1016/j.ajpath.2012.06.024
   Bosco N, 2021, GENES IMMUN, V22, P289, DOI 10.1038/s41435-021-00126-8
   Bowker SL, 2010, DIABETOLOGIA, V53, P1631, DOI 10.1007/s00125-010-1750-8
   Buffie CG, 2015, NATURE, V517, P205, DOI 10.1038/nature13828
   Buffie CG, 2013, NAT REV IMMUNOL, V13, P790, DOI 10.1038/nri3535
   Buford TW, 2017, MICROBIOME, V5, DOI 10.1186/s40168-017-0296-0
   Buford TW, 2016, AGEING RES REV, V26, P96, DOI 10.1016/j.arr.2016.01.007
   Calderon-Perez L, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-63475-w
   Cameron AR, 2016, CIRC RES, V119, P652, DOI 10.1161/CIRCRESAHA.116.308445
   Campbell JM, 2017, AGEING RES REV, V40, P31, DOI 10.1016/j.arr.2017.08.003
   Carloni S, 2021, SCIENCE, V374, P439, DOI 10.1126/science.abc6108
   Carlson JL, 2017, NUTRIENTS, V9, DOI 10.3390/nu9121361
   Casati M, 2019, EXP GERONTOL, V124, DOI 10.1016/j.exger.2019.110639
   Cassani E, 2015, PARKINSONISM RELAT D, V21, P389, DOI 10.1016/j.parkreldis.2015.02.004
   Cattaneo A, 2017, NEUROBIOL AGING, V49, P60, DOI 10.1016/j.neurobiolaging.2016.08.019
   Cersosimo MG, 2012, NEUROBIOL DIS, V46, P559, DOI 10.1016/j.nbd.2011.10.014
   Chen C, 2009, SCI SIGNAL, V2, DOI 10.1126/scisignal.2000559
   Chen J, 2017, ELIFE, V6, DOI 10.7554/eLife.31268
   Chen LH, 2019, AGING-US, V11, P756, DOI 10.18632/aging.101782
   Chen YM, 2016, NUTRIENTS, V8, DOI 10.3390/nu8040205
   Claesson MJ, 2012, NATURE, V488, P178, DOI 10.1038/nature11319
   D'Amico F, 2022, CURR MED CHEM, V29, P3202, DOI 10.2174/0929867329666220105121754
   Ghizi ACD, 2021, PHARMANUTRITION, V16, DOI 10.1016/j.phanu.2021.100266
   Danchin A, 2018, ENVIRON MICROBIOL, V20, P1966, DOI 10.1111/1462-2920.14255
   de Oliveira MA, 2011, ORAL ONCOL, V47, P998, DOI 10.1016/j.oraloncology.2011.08.009
   Depommier C, 2019, NAT MED, V25, P1096, DOI 10.1038/s41591-019-0495-2
   Derrien M, 2019, TRENDS MICROBIOL, V27, P997, DOI 10.1016/j.tim.2019.08.001
   Derrien M, 2017, TRENDS MICROBIOL, V25, P100, DOI 10.1016/j.tim.2016.09.011
   Deschasaux M, 2018, NAT MED, V24, P1526, DOI 10.1038/s41591-018-0160-1
   Dhahbi JM, 2005, PHYSIOL GENOMICS, V23, P343, DOI 10.1152/physiolgenomics.00069.2005
   Di Pede G, 2020, FOODS, V9, DOI 10.3390/foods9081121
   Dinan TG, 2013, BIOL PSYCHIAT, V74, P720, DOI 10.1016/j.biopsych.2013.05.001
   Duvallet C, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-01973-8
   Emoto T, 2016, J ATHEROSCLER THROMB, V23, P908, DOI 10.5551/jat.32672
   Falony G, 2016, SCIENCE, V352, P560, DOI 10.1126/science.aad3503
   Fan XL, 2015, ONCOTARGET, V6, P35274, DOI 10.18632/oncotarget.5895
   Fassarella M, 2021, GUT, V70, P595, DOI 10.1136/gutjnl-2020-321747
   Ferretti P, 2018, CELL HOST MICROBE, V24, P133, DOI 10.1016/j.chom.2018.06.005
   Flanagan E, 2020, AGEING RES REV, V62, DOI 10.1016/j.arr.2020.101079
   Flynn JM, 2013, AGING CELL, V12, P851, DOI 10.1111/acel.12109
   Ford AC, 2014, AM J GASTROENTEROL, V109, P1547, DOI 10.1038/ajg.2014.202
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Freedberg DE, 2015, GASTROENTEROLOGY, V149, P883, DOI 10.1053/j.gastro.2015.06.043
   Gandini S, 2014, CANCER PREV RES, V7, P867, DOI 10.1158/1940-6207.CAPR-13-0424
   Gensous N, 2020, SEMIN IMMUNOPATHOL, V42, P635, DOI 10.1007/s00281-020-00804-1
   Ghosh TS, 2020, GUT, V69, P1218, DOI 10.1136/gutjnl-2019-319654
   Greenhill C, 2018, NAT REV ENDOCRINOL, V15, P2, DOI 10.1038/s41574-018-0133-y
   Halloran J, 2012, NEUROSCIENCE, V223, P102, DOI 10.1016/j.neuroscience.2012.06.054
   Haran JP, 2019, MBIO, V10, DOI 10.1128/mBio.00632-19
   Haran JP, 2018, J MED MICROBIOL, V67, P40, DOI 10.1099/jmm.0.000640
   Harrison DE, 2009, NATURE, V460, P392, DOI 10.1038/nature08221
   Hayden EC, 2015, NATURE, V522, P265, DOI 10.1038/522265a
   He Y, 2018, NAT MED, V24, P1532, DOI 10.1038/s41591-018-0164-x
   Hickson LJ, 2019, EBIOMEDICINE, V47, P446, DOI 10.1016/j.ebiom.2019.08.069
   Hoyles L, 2021, MICROBIOME, V9, DOI 10.1186/s40168-021-01181-z
   Huang CC, 2014, INT J MOL SCI, V15, P8280, DOI 10.3390/ijms15058280
   Huang WC, 2019, NUTRIENTS, V11, DOI 10.3390/nu11112836
   Ibanez L, 2006, HUM REPROD, V21, P451, DOI 10.1093/humrep/dei329
   Iliev ID, 2017, NAT REV IMMUNOL, V17, P635, DOI 10.1038/nri.2017.55
   Jackson M, 2016, GENOME MED, V8, DOI 10.1186/s13073-016-0262-7
   Jackson MA, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-018-05184-7
   Jackson MA, 2016, GUT, V65, P749, DOI 10.1136/gutjnl-2015-310861
   Jie ZY, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-00900-1
   Jochum L, 2020, TRENDS MICROBIOL, V28, P789, DOI 10.1016/j.tim.2020.04.011
   Justice JN, 2019, EBIOMEDICINE, V40, P554, DOI 10.1016/j.ebiom.2018.12.052
   Kawabata K, 2019, MOLECULES, V24, DOI 10.3390/molecules24020370
   Keshavarzian A, 2015, MOVEMENT DISORD, V30, P1351, DOI 10.1002/mds.26307
   Khalesi S, 2014, HYPERTENSION, V64, P897, DOI 10.1161/HYPERTENSIONAHA.114.03469
   Kirkland JL, 2017, EBIOMEDICINE, V21, P21, DOI 10.1016/j.ebiom.2017.04.013
   Klunemann M, 2021, NATURE, V597, P533, DOI 10.1038/s41586-021-03891-8
   Konikoff T, 2016, TRENDS MICROBIOL, V24, P523, DOI 10.1016/j.tim.2016.02.015
   Kooy A, 2009, ARCH INTERN MED, V169, P616, DOI 10.1001/archinternmed.2009.20
   Koren O, 2011, P NATL ACAD SCI USA, V108, P4592, DOI 10.1073/pnas.1011383107
   Kundu P, 2017, CELL, V171, P1481, DOI 10.1016/j.cell.2017.11.024
   Latorre E, 2017, BMC CELL BIOL, V18, DOI 10.1186/s12860-017-0147-7
   Lee MC, 2021, MICROORGANISMS, V9, DOI 10.3390/microorganisms9071466
   Leffler DA, 2015, NEW ENGL J MED, V372, P1539, DOI 10.1056/NEJMra1403772
   Levy M, 2017, NAT REV IMMUNOL, V17, P219, DOI 10.1038/nri.2017.7
   Li W, 2017, SCI CHINA LIFE SCI, V60, P1223, DOI 10.1007/s11427-016-9001-4
   Liang GX, 2021, NAT REV MICROBIOL, V19, P514, DOI 10.1038/s41579-021-00536-5
   Liao XL, 2020, NEUROL SCI, V41, P2045, DOI 10.1007/s10072-020-04303-x
   Lim ES, 2018, MICROBIOME, V6, DOI 10.1186/s40168-018-0475-7
   Lin R, 2017, AMINO ACIDS, V49, P2083, DOI 10.1007/s00726-017-2493-3
   Lochlainn MN, 2021, BMC GERIATR, V21, DOI 10.1186/s12877-021-02301-y
   Longo VD, 2015, AGING CELL, V14, P497, DOI 10.1111/acel.12338
   Ma JH, 2022, MICROB CELL FACT, V21, DOI 10.1186/s12934-022-01799-0
   Mahler A, 2020, TRIALS, V21, DOI 10.1186/s13063-020-04973-0
   Maier L, 2018, NATURE, V555, P623, DOI 10.1038/nature25979
   Maier R, 2020, JMIR RES PROTOC, V9, DOI 10.2196/19456
   Makivuokko H, 2010, BRIT J NUTR, V103, P227, DOI 10.1017/S0007114509991553
   Marshall SM, 2017, DIABETOLOGIA, V60, P1561, DOI 10.1007/s00125-017-4343-y
   Martin-Montalvo A, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms3192
   Mas-Capdevila A, 2020, NUTRIENTS, V12, DOI 10.3390/nu12051488
   Maseda D, 2020, FRONT PHARMACOL, V11, DOI 10.3389/fphar.2020.01153
   Matchado MS, 2021, COMPUT STRUCT BIOTEC, V19, P2687, DOI 10.1016/j.csbj.2021.05.001
   Mertz KH, 2021, AM J CLIN NUTR, V113, P790, DOI 10.1093/ajcn/nqaa372
   Minato T, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0187307
   Miyazato S, 2016, BIOSCI MICROB FOOD H, V35, P1, DOI 10.12938/bmfh.2015-009
   Moiseeva O, 2013, AGING CELL, V12, P489, DOI 10.1111/acel.12075
   MORTENSEN FV, 1990, GUT, V31, P1391, DOI 10.1136/gut.31.12.1391
   Mulak A, 2015, WORLD J GASTROENTERO, V21, P10609, DOI 10.3748/wjg.v21.i37.10609
   Munoz-Espin D, 2014, NAT REV MOL CELL BIO, V15, P482, DOI 10.1038/nrm3823
   Nagpal Ravinder, 2018, Nutr Healthy Aging, V4, P267, DOI 10.3233/NHA-170030
   Narasimhan H, 2021, MICROORGANISMS, V9, DOI 10.3390/microorganisms9030555
   Oliveros E, 2020, CLIN CARDIOL, V43, P99, DOI 10.1002/clc.23303
   Onken B, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0008758
   Palmer AK, 2019, AGING CELL, V18, DOI 10.1111/acel.12950
   Palmu J, 2020, J AM HEART ASSOC, V9, DOI 10.1161/JAHA.120.016641
   Parker SE, 2010, BIRTH DEFECTS RES A, V88, P1008, DOI 10.1002/bdra.20735
   Partridge L, 2020, NAT REV DRUG DISCOV, V19, P513, DOI 10.1038/s41573-020-0067-7
   Patterson D, 2012, MECH AGEING DEV, V133, P133, DOI 10.1016/j.mad.2011.10.001
   Perez-Vizcaino F, 2009, PHARMACOL REP, V61, P67, DOI 10.1016/S1734-1140(09)70008-8
   Petrov VA, 2017, B EXP BIOL MED+, V162, P734, DOI 10.1007/s10517-017-3700-7
   Piggott DA, 2020, TRANSL RES, V221, P23, DOI 10.1016/j.trsl.2020.03.012
   Piggott DA, 2016, CURR HIV-AIDS REP, V13, P340, DOI 10.1007/s11904-016-0334-8
   Pluznick JL, 2014, GUT MICROBES, V5, P202, DOI 10.4161/gmic.27492
   Pollizzi KN, 2016, NAT IMMUNOL, V17, P704, DOI 10.1038/ni.3438
   Pushpakom S, 2019, NAT REV DRUG DISCOV, V18, P41, DOI 10.1038/nrd.2018.168
   Qian YW, 2018, BRAIN BEHAV IMMUN, V70, P194, DOI 10.1016/j.bbi.2018.02.016
   Rampelli S, 2020, MSYSTEMS, V5, DOI 10.1128/mSystems.00124-20
   Rekdal VM, 2019, SCIENCE, V364, P1055, DOI 10.1126/science.aau6323
   Ren SM, 2022, EUR CHILD ADOLES PSY, V31, P189, DOI 10.1007/s00787-021-01799-2
   Rocha DM, 2016, ATHEROSCLEROSIS, V244, P211, DOI 10.1016/j.atherosclerosis.2015.11.015
   Rogers MAM, 2016, CLIN MICROBIOL INFEC, V22, DOI 10.1016/j.cmi.2015.10.003
   Romano S, 2021, NPJ PARKINSONS DIS, V7, DOI 10.1038/s41531-021-00156-z
   Rothschild D, 2018, NATURE, V555, P210, DOI 10.1038/nature25973
   Ruiter R, 2012, DIABETES CARE, V35, P119, DOI 10.2337/dc11-0857
   Santisteban MM, 2017, CIRC RES, V120, P312, DOI 10.1161/CIRCRESAHA.116.309006
   Santoro A, 2018, CELL MOL LIFE SCI, V75, P129, DOI 10.1007/s00018-017-2674-y
   Satoh T, 2016, MICROBIOL SPECTR, V4, DOI 10.1128/microbiolspec.MCHD-0040-2016
   Saxton RA, 2017, CELL, V168, P960, DOI [10.1016/j.cell.2017.02.004, 10.1016/j.cell.2017.03.035]
   Schinaman JM, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-44106-5
   Segal A, 2021, CLIN NEUROL NEUROSUR, V207, DOI 10.1016/j.clineuro.2021.106791
   Shanahan F, 2014, GASTROENTEROLOGY, V146, P1554, DOI 10.1053/j.gastro.2014.01.050
   Shao Z, 2021, OSTEOARTHR CARTILAGE, V29, P413, DOI 10.1016/j.joca.2020.11.006
   Sharon G, 2016, CELL, V167, P915, DOI 10.1016/j.cell.2016.10.027
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Siddharth J, 2017, AGING-US, V9, P1698, DOI 10.18632/aging.101262
   Silveira-Nunes G, 2020, FRONT PHARMACOL, V11, DOI 10.3389/fphar.2020.00258
   Slavin J, 2013, NUTRIENTS, V5, P1417, DOI 10.3390/nu5041417
   Spanogiannopoulos P, 2016, NAT REV MICROBIOL, V14, P273, DOI 10.1038/nrmicro.2016.17
   Springer M, 2019, NUTRIENTS, V11, DOI 10.3390/nu11010143
   Sterpu I, 2021, AM J OBSTET GYNECOL, V224, DOI 10.1016/j.ajog.2020.08.103
   Stewart CJ, 2018, NATURE, V562, P583, DOI 10.1038/s41586-018-0617-x
   Syed YY, 2020, DRUGS, V80, P441, DOI 10.1007/s40265-020-01268-1
   Tan AH, 2021, NEUROLOGY, V96, pE772, DOI 10.1212/WNL.0000000000010998
   Tavella T, 2021, MSPHERE, V6, DOI 10.1128/mSphere.00691-21
   Tavella T, 2021, GUT MICROBES, V13, DOI 10.1080/19490976.2021.1880221
   Ticinesi A, 2019, NUTRIENTS, V11, DOI 10.3390/nu11071633
   Ticinesi A, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-10734-y
   Trotta MBF, 2011, IMMUN AGEING, V8, DOI 10.1186/1742-4933-8-4
   Tsoukalas D, 2019, MOL MED REP, V20, P3701, DOI 10.3892/mmr.2019.10614
   Turck D, 2021, EFSA J, V19, DOI 10.2903/j.efsa.2021.6780
   Turner RC, 1998, LANCET, V352, P854, DOI 10.1016/s0140-6736(98)07037-8
   Turroni S, 2018, J MED CHEM, V61, P47, DOI 10.1021/acs.jmedchem.7b00244
   Unger MM, 2016, PARKINSONISM RELAT D, V32, P66, DOI 10.1016/j.parkreldis.2016.08.019
   van Kessel SP, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-08294-y
   van Tongeren SP, 2005, APPL ENVIRON MICROB, V71, P6438, DOI 10.1128/AEM.71.10.6438-6442.2005
   Verbist KC, 2016, NATURE, V532, P389, DOI 10.1038/nature17442
   Verdi S, 2018, FRONT AGING NEUROSCI, V10, DOI 10.3389/fnagi.2018.00398
   Verhaar B.J.H., 2020, EUR HEART J, DOI DOI 10.1093/eurheartj/ehaa704
   Vila AV, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-019-14177-z
   Vogt NM, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-13601-y
   Vujkovic-Cvijin I, 2020, NATURE, V587, P448, DOI 10.1038/s41586-020-2881-9
   Wang CP, 2017, J DIABETES COMPLICAT, V31, P679, DOI [10.1016/jjdiacomp.2017.01.013, 10.1016/j.jdiacomp.2017.01.013]
   Wang SP, 2021, GUT MICROBES, V13, DOI 10.1080/19490976.2021.1911571
   Wang X, 2021, OPEN MED-WARSAW, V16, P1525, DOI 10.1515/med-2021-0364
   Wang XY, 2019, CELL RES, V29, P787, DOI 10.1038/s41422-019-0216-x
   Wang ZN, 2011, NATURE, V472, P57, DOI 10.1038/nature09922
   Weersma RK, 2020, GUT, V69, P1510, DOI 10.1136/gutjnl-2019-320204
   Wilmanski T, 2021, NAT METAB, V3, P274, DOI 10.1038/s42255-021-00348-0
   Wilms E, 2021, CLIN NUTR, V40, P3019, DOI 10.1016/j.clnu.2020.12.034
   Wilson ID, 2017, TRANSL RES, V179, P204, DOI 10.1016/j.trsl.2016.08.002
   Witkowski M, 2020, CIRC RES, V127, P553, DOI 10.1161/CIRCRESAHA.120.316242
   Wu CS, 2020, J GERONTOL A-BIOL, V75, P621, DOI 10.1093/gerona/gly256
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Xiao LW, 2021, GENOME BIOL, V22, DOI 10.1186/s13059-021-02463-3
   Xu L, 2020, LIFE SCI, V253, DOI 10.1016/j.lfs.2020.117747
   Xu M, 2018, NAT MED, V24, P1246, DOI 10.1038/s41591-018-0092-9
   Xue QL, 2011, CLIN GERIATR MED, V27, P1, DOI 10.1016/j.cger.2010.08.009
   Yousefzadeh MJ, 2018, EBIOMEDICINE, V36, P18, DOI 10.1016/j.ebiom.2018.09.015
   Zhong HZ, 2019, MICROBIOME, V7, DOI 10.1186/s40168-018-0608-z
   Zhu WF, 2016, CELL, V165, P111, DOI 10.1016/j.cell.2016.02.011
   Zhu Y, 2016, AGING CELL, V15, P428, DOI 10.1111/acel.12445
   Zhu Y, 2015, AGING CELL, V14, P644, DOI 10.1111/acel.12344
   Zhuang ZQ, 2018, J ALZHEIMERS DIS, V63, P1337, DOI 10.3233/JAD-180176
   Zimmermann M, 2019, NATURE, V570, P462, DOI 10.1038/s41586-019-1291-3
NR 213
TC 5
Z9 5
U1 10
U2 20
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0047-6374
EI 1872-6216
J9 MECH AGEING DEV
JI Mech. Ageing Dev.
PD SEP
PY 2022
VL 206
AR 111711
DI 10.1016/j.mad.2022.111711
EA JUL 2022
PG 17
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Geriatrics & Gerontology
GA 3Z8BG
UT WOS:000844639900001
PM 35868543
DA 2023-06-08
ER

PT J
AU Lang, UE
   Beglinger, C
   Schweinfurth, N
   Walter, M
   Borgwardt, S
AF Lang, Undine E.
   Beglinger, Christoph
   Schweinfurth, Nina
   Walter, Marc
   Borgwardt, Stefan
TI Nutritional Aspects of Depression
SO CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Review
DE Nutrition; Food; Diet; Depression; Microbiota; Leptin; Ghrelin; IGF;
   BDNF; Insulin
ID PIOGLITAZONE ADJUNCTIVE THERAPY; MEDITERRANEAN DIETARY PATTERN; FACTOR
   SERUM CONCENTRATIONS; MENTAL-HEALTH PROBLEMS; GREEN TEA EXTRACT;
   QUALITY-OF-LIFE; DOUBLE-BLIND; MAJOR DEPRESSION; RISK-FACTOR; FURUKAWA
   NUTRITION
AB Several nutrition, food and dietary compounds have been suggested to be involved in the onset and maintenance of depressive disorders and in the severity of depressive symptoms. Nutritional compounds might modulate depression associated biomarkers and parallel the development of depression, obesity and diabetes. In this context, recent studies revealed new mediators of both energy homeostasis and mood changes (i.e. IGF-1, NPY, BDNF, ghrelin, leptin, CCK, GLP-1, AGE, glucose metabolism and microbiota) acting in gut brain circuits. In this context several healthy foods such as olive oil, fish, fruits, vegetables, nuts, legumes, poultry, dairy and unprocessed meat have been inversely associated with depression risk and even have been postulated to improve depressive symptoms. In contrast, unhealthy western dietary patterns including the consumption of sweetened beverage, refined food, fried food, processed meat, refined grain, and high fat diary, biscuits, snacking and pastries have been shown to be associated with an increased risk of depression in longitudinal studies. However, it is always difficult to conclude a real prospective causal relationship from these mostly retrospective studies as depressed individuals might also change their eating habits secondarily to their depression. Additionally specific selected nutritional compounds, e.g. calcium, chromium, folate, PUFAs, vitamin D, B12, zinc, magnesium and D-serine have been postulated to be used as ad-on strategies in antidepressant treatment. In this context, dietary and lifestyle interventions may be a desirable, effective, pragmatical and non-stigmatizing prevention and treatment strategy for depression. At last, several medications (pioglitazone, metformin, exenatide, atorvastatin, gram-negative antibiotics), which have traditionally been used to treat metabolic disorders showed a certain potential to treat depression in first randomized controlled clinical trials. (C) 2015 The Author(s) Published by S. Karger AG, Basel
C1 [Lang, Undine E.; Schweinfurth, Nina; Walter, Marc; Borgwardt, Stefan] Univ Psychiat Clin UPK, Dept Psychiat & Psychotherapy, CH-4012 Basel, Switzerland.
   [Beglinger, Christoph] Univ Basel Hosp, Dept Gastroenterol, Basel, Switzerland.
C3 University of Basel
RP Lang, UE (通讯作者)，Univ Psychiat Clin UPK, Dept Psychiat & Psychotherapy, Wilhelm Klein Str 27, CH-4012 Basel, Switzerland.
EM undine.lang@upkbs.ch
RI Borgwardt, Stefan/Q-6168-2018
OI Borgwardt, Stefan/0000-0002-5792-3987; Walter, Marc/0000-0002-2238-2017
CR Aberg MAI, 2000, J NEUROSCI, V20, P2896
   Ackermann TF, 2010, CELL PHYSIOL BIOCHEM, V25, P775, DOI 10.1159/000315097
   Ackermann TF, 2008, CELL PHYSIOL BIOCHEM, V22, P735, DOI 10.1159/000185557
   Akhondzadeh S, 2013, PSYCHIAT CLIN N AM, V36, P25, DOI 10.1016/j.psc.2012.12.003
   Almeida OP, 2010, ANN NEUROL, V68, P503, DOI 10.1002/ana.22189
   Anderson MF, 2002, DEV BRAIN RES, V134, P115
   Arey RN, 2014, MOL PSYCHIATR, V19, P342, DOI 10.1038/mp.2013.12
   Bandaru SS, 2010, PHYSIOL BEHAV, V100, P239, DOI 10.1016/j.physbeh.2009.10.019
   Barragan-Rodriguez L, 2008, MAGNESIUM RES, V21, P218
   Becker C, 2008, MOL PSYCHIATR, V13, P1079, DOI 10.1038/sj.mp.4002097
   Beezhold BL, 2012, NUTR J, V11, DOI 10.1186/1475-2891-11-9
   Beezhold BL, 2010, NUTR J, V9, DOI 10.1186/1475-2891-9-26
   Belue R, 2009, PEDIATRICS, V123, P697, DOI 10.1542/peds.2008-0687
   Bloch MH, 2012, MOL PSYCHIATR, V17, P1272, DOI 10.1038/mp.2011.100
   Borgwardt S, 2012, EUR J CLIN NUTR, V66, P1187, DOI 10.1038/ejcn.2012.105
   Bouwman V, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009971
   Bravo JA, 2011, P NATL ACAD SCI USA, V108, P16050, DOI 10.1073/pnas.1102999108
   Chan R, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0105760
   Ciarambino T, 2012, CLIN NEPHROL, V78, P122, DOI 10.5414/CN107279
   Cline BH, 2012, BMC NEUROSCI, V13, DOI 10.1186/1471-2202-13-110
   Convit A, 2003, P NATL ACAD SCI USA, V100, P2019, DOI 10.1073/pnas.0336073100
   Cooke L, 2007, DEPRESSION AND PHYSICAL ILLNESS, P238
   Cryan JF, 2012, NAT REV NEUROSCI, V13, P701, DOI 10.1038/nrn3346
   David LA, 2014, NATURE, V505, P559, DOI 10.1038/nature12820
   Davidson JRT, 2003, BIOL PSYCHIAT, V53, P261, DOI 10.1016/S0006-3223(02)01500-7
   Davis J D, 2007, Minerva Endocrinol, V32, P49
   Deutschenbaur L, 2016, PROG NEURO-PSYCHOPH, V64, P325, DOI 10.1016/j.pnpbp.2015.02.015
   Dipnall JF, 2015, J AFFECT DISORDERS, V174, P215, DOI 10.1016/j.jad.2014.11.030
   Dowlati Y, 2010, BIOL PSYCHIAT, V67, P446, DOI 10.1016/j.biopsych.2009.09.033
   Dumville JC, 2006, J NUTR HEALTH AGING, V10, P151
   Eby GA, 2010, MED HYPOTHESES, V74, P649, DOI 10.1016/j.mehy.2009.10.051
   Engali L., 2014, J VASC MED SURG, V2, P3, DOI DOI 10.4172/2329-6925.1000141
   Faith MS, 2011, OBES REV, V12, pe438, DOI 10.1111/j.1467-789X.2010.00843.x
   Fares H, 2014, CURR ATHEROSCLER REP, V16, DOI 10.1007/s11883-013-0389-6
   Florez KR, 2015, J ACAD NUTR DIET, V115, P1102, DOI 10.1016/j.jand.2015.01.001
   Forman-Hoffman VL, 2007, J GERONTOL B-PSYCHOL, V62, pS43, DOI 10.1093/geronb/62.1.S43
   Frey A, 2007, NEUROPSYCHOBIOLOGY, V56, P123, DOI 10.1159/000112954
   Friedman MA, 2002, EATING DISORDERS OBE, P50
   Fulton S, 2006, NEURON, V51, P811, DOI 10.1016/j.neuron.2006.09.006
   Gallinat J, 2010, NEUROIMAGE, V49, P767, DOI 10.1016/j.neuroimage.2009.08.018
   Gangwisch JE, 2015, AM J CLIN NUTR, V102, P454, DOI 10.3945/ajcn.114.103846
   Garate I, 2013, BIOL PSYCHIAT, V73, P32, DOI 10.1016/j.biopsych.2012.07.005
   Garza JC, 2012, MOL PSYCHIATR, V17, P790, DOI 10.1038/mp.2011.161
   Ghafari M, 2015, BRAIN STRUCT FUNCT, V220, P2209, DOI 10.1007/s00429-014-0779-8
   Gois C, 2012, J AFFECT DISORDERS, V142, pS67, DOI 10.1016/S0165-0327(12)70010-1
   Gold SM, 2007, DIABETOLOGIA, V50, P711, DOI 10.1007/s00125-007-0602-7
   Grant P, 2011, J DIABETES COMPLICAT, V25, P244, DOI 10.1016/j.jdiacomp.2011.03.002
   Green RC, 2003, ARCH NEUROL-CHICAGO, V60, P753, DOI 10.1001/archneur.60.5.753
   Grunbaum-Novak N, 2008, EUR NEUROPSYCHOPHARM, V18, P431, DOI 10.1016/j.euroneuro.2007.08.004
   Guo M, 2014, CLIN EXP PHARMACOL P, V41, P650, DOI 10.1111/1440-1681.12265
   Hafner S, 2012, BIOL PSYCHOL, V89, P163, DOI 10.1016/j.biopsycho.2011.10.005
   Haghighi M, 2014, J PSYCHIATR RES, V58, P109, DOI 10.1016/j.jpsychires.2014.07.018
   Hesdorffer DC, 2000, ANN NEUROL, V47, P246, DOI 10.1002/1531-8249(200002)47:2<246::AID-ANA17>3.0.CO;2-E
   Hoang MT, 2011, MAYO CLIN PROC, V86, P1050, DOI 10.4065/mcp.2011.0208
   Homan P, 2014, INT J NEUROPSYCHOPH, V18, P5
   Hommel JD, 2006, NEURON, V51, P801, DOI 10.1016/j.neuron.2006.08.023
   Hoshaw BA, 2008, EUR J PHARMACOL, V594, P109, DOI 10.1016/j.ejphar.2008.07.023
   Jacka FN, 2013, SOC PSYCH PSYCH EPID, V48, P1297, DOI 10.1007/s00127-012-0623-5
   Jorgensen BP, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0103398
   KAY DSG, 1984, PSYCHOL MED, V14, P533, DOI 10.1017/S0033291700015142
   Kilhovd BK, 2007, DIABETOLOGIA, V50, P1409, DOI 10.1007/s00125-007-0687-z
   Kluge M, 2011, J PSYCHIATR RES, V45, P421, DOI 10.1016/j.jpsychires.2010.09.002
   Knight A, 2015, BMC GERIATR, V15, DOI 10.1186/s12877-015-0054-8
   Kuo LE, 2007, NAT MED, V13, P803, DOI 10.1038/nm1611
   Lang UE, 2005, PSYCHOPHARMACOLOGY, V180, P95, DOI 10.1007/s00213-004-2137-7
   Lang UE, 2006, PSYCHOPHARMACOLOGY, V187, P56, DOI 10.1007/s00213-006-0399-y
   Lang UE, 2013, CELL PHYSIOL BIOCHEM, V31, P761, DOI 10.1159/000350094
   Lazarou Chrystalleni, 2010, Complement Ther Clin Pract, V16, P161, DOI 10.1016/j.ctcp.2010.01.003
   Leclercq S, 2014, P NATL ACAD SCI USA, V111, pE4485, DOI 10.1073/pnas.1415174111
   Leibrock C, 2013, CELL PHYSIOL BIOCHEM, V32, P766, DOI 10.1159/000354478
   Logan AC, 2005, MED HYPOTHESES, V64, P533, DOI 10.1016/j.mehy.2004.08.019
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Malberg JE, 2007, NEUROPSYCHOPHARMACOL, V32, P2360, DOI 10.1038/sj.npp.1301358
   Malkesman O, 2012, INT J NEUROPSYCHOPH, V15, P1135, DOI 10.1017/S1461145711001386
   Marano CM, 2014, PSYCHIAT RES-NEUROIM, V222, P84, DOI 10.1016/j.pscychresns.2014.01.009
   Markowitz S, 2008, CLIN PSYCHOL-SCI PR, V15, P1, DOI 10.1111/j.1468-2850.2008.00106.x
   Mason BL, 2013, OBESITY, V21, P2372, DOI 10.1002/oby.20382
   Mayer EA, 2015, J CLIN INVEST, V125, P926, DOI 10.1172/JCI76304
   MCCARTY MF, 1994, MED HYPOTHESES, V43, P253, DOI 10.1016/0306-9877(94)90076-0
   McLean A, 2004, PSYCHOPHARMACOLOGY, V171, P286, DOI 10.1007/s00213-003-1586-8
   McLeod MN, 1999, J CLIN PSYCHIAT, V60, P237, DOI 10.4088/JCP.v60n0406
   McLeod MN, 2000, INT J NEUROPSYCHOPH, V3, P311, DOI 10.1017/S146114570000208X
   Messaoudi M, 2011, BRIT J NUTR, V105, P755, DOI 10.1017/S0007114510004319
   Miki T, 2015, NUTRITION, V31, P686, DOI 10.1016/j.nut.2014.11.002
   Miyake Y, 2015, BJOG-INT J OBSTET GY, V122, P336, DOI 10.1111/1471-0528.12972
   Morales-Medina JC, 2010, BRAIN RES, V1314, P194, DOI 10.1016/j.brainres.2009.09.077
   Muller TD, 2015, MOL METAB, V4, P437, DOI 10.1016/j.molmet.2015.03.005
   Murck H, 2013, J PSYCHIATR RES, V47, P955, DOI 10.1016/j.jpsychires.2013.02.015
   Nanri A, 2014, PSYCHIAT RES, V220, P263, DOI 10.1016/j.psychres.2014.08.026
   Naseribafrouei A, 2014, NEUROGASTROENT MOTIL, V26, P1155, DOI 10.1111/nmo.12378
   NAYLOR GJ, 1981, PSYCHOL MED, V11, P249, DOI 10.1017/S0033291700052065
   Neufeld KM, 2011, NEUROGASTROENT MOTIL, V23, DOI 10.1111/j.1365-2982.2010.01620.x
   Nouwen Arie, 2009, Diabetes Care, V32, pe57, DOI 10.2337/dc09-0027
   Onyike CU, 2003, AM J EPIDEMIOL, V158, P1139, DOI 10.1093/aje/kwg275
   Opie RS, 2015, PUBLIC HEALTH NUTR, V18, P2074, DOI 10.1017/S1368980014002614
   Otte DM, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0067131
   Panagiotakos DB, 2010, J AM COLL NUTR, V29, P586, DOI 10.1080/07315724.2010.10719897
   Park Y, 2015, ANN NUTR METAB, V66, P141, DOI 10.1159/000377640
   Penninx BWJH, 1998, J NATL CANCER I, V90, P1888, DOI 10.1093/jnci/90.24.1888
   Perez-Cornago A, 2014, NUTR J, V24, P13
   Pochwat B, 2014, EXPERT OPIN INV DRUG, V23, P1181, DOI 10.1517/13543784.2014.918951
   Preiss K, 2013, OBES REV, V14, P906, DOI 10.1111/obr.12052
   Prohan M, 2014, REDOX REP, V19, P133, DOI 10.1179/1351000214Y.0000000085
   Psaltopoulou T, 2013, ANN NEUROL, V74, P580, DOI 10.1002/ana.23944
   Ramasubbu R, 2003, CAN J PSYCHIAT, V48, P250, DOI 10.1177/070674370304800409
   Reynolds CF, 2012, ANNU REV PUBL HEALTH, V33, P123, DOI 10.1146/annurev-publhealth-031811-124544
   Reynolds EH, 2002, BMJ-BRIT MED J, V324, P1512, DOI 10.1136/bmj.324.7352.1512
   Ricken R, 2013, J CLIN PSYCHOPHARM, V33, P806, DOI 10.1097/JCP.0b013e3182a412b8
   Roesler R., 2006, CNS & Neurological Disorders-Drug Targets, V5, P197, DOI 10.2174/187152706776359673
   Rondanelli M, 2009, BRIT J NUTR, V101, P457, DOI 10.1017/S0007114508024008
   Ruusunen A, 2014, J AFFECT DISORDERS, V159, P1, DOI 10.1016/j.jad.2014.01.020
   Sahraian A, 2015, TRIALS, V16, DOI 10.1186/s13063-015-0609-1
   Salehi-Sadaghiani M, 2012, PSYCHOPHARMACOLOGY, V223, P345, DOI 10.1007/s00213-012-2722-0
   Sanchez-Villegas A, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-208
   Sawada T, 2010, EUR J CLIN NUTR, V64, P331, DOI 10.1038/ejcn.2009.158
   Saxholt E., 2009, DANISH FOOD COMPOSIT
   Schellekens H, 2012, PHARMACOL THERAPEUT, V135, P316, DOI 10.1016/j.pharmthera.2012.06.004
   Schmidt A, 2014, PSYCHOPHARMACOLOGY, V231, P3879, DOI 10.1007/s00213-014-3526-1
   Schmidt K, 2015, PSYCHOPHARMACOLOGY, V232, P1793, DOI 10.1007/s00213-014-3810-0
   Scott LV, 2013, MOD TR PHARMACOPSYCH, V28, P90, DOI 10.1159/000343971
   Sepanjnia K, 2012, NEUROPSYCHOPHARMACOL, V37, P2093, DOI 10.1038/npp.2012.58
   Ripoll MJS, 2015, J AFFECT DISORDERS, V183, P221, DOI 10.1016/j.jad.2015.04.059
   Sharpley AL, 2014, J AFFECT DISORDERS, V167, P306, DOI 10.1016/j.jad.2014.06.011
   Shonesy BC, 2014, PROG MOL BIOL TRANSL, V122, P61, DOI 10.1016/B978-0-12-420170-5.00003-9
   Smith KJ, 2014, AM J EPIDEMIOL, V179, P1228, DOI 10.1093/aje/kwu050
   Stafford L, 2011, J CLIN PSYCHIAT, V72, P1229, DOI 10.4088/JCP.09m05825blu
   Stahl ST, 2014, AM J PSYCHIAT, V171, P499, DOI 10.1176/appi.ajp.2013.13101373
   Strohle A, 2003, ARCH GEN PSYCHIAT, V60, P161, DOI 10.1001/archpsyc.60.2.161
   Surwit RS, 1997, AM J CLIN NUTR, V65, P908, DOI 10.1093/ajcn/65.4.908
   Szegedi V, 2011, NEUROCHEM INT, V59, P1109, DOI 10.1016/j.neuint.2011.10.008
   Tan KCB, 2002, DIABETES CARE, V25, P1055, DOI 10.2337/diacare.25.6.1055
   Ubbenhorst A, 2011, PSYCHOPHARMACOLOGY, V215, P733, DOI 10.1007/s00213-011-2175-x
   Van der Kooy K, 2007, INT J GERIATR PSYCH, V22, P613, DOI 10.1002/gps.1723
   Vashum KP, 2014, J AFFECT DISORDERS, V166, P249, DOI 10.1016/j.jad.2014.05.016
   Vasselli JR, 2013, ADV NUTR, V4, P164, DOI 10.3945/an.112.003152
   Vlassara H, 2011, NAT REV ENDOCRINOL, V7, P526, DOI 10.1038/nrendo.2011.74
   Wexler DJ, 2012, DIABETES CARE, V35, P1575, DOI 10.2337/dc11-2266
   Widmer RJ, 2015, AM J MED, V128, P229, DOI 10.1016/j.amjmed.2014.10.014
   Wolnerhanssen BK, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0130280
   Zeinoddini A, 2015, DEPRESS ANXIETY, V32, P167, DOI 10.1002/da.22340
   Zhou LH, 2015, NEUROPSYCH DIS TREAT, V11, P715, DOI 10.2147/NDT.S61997
NR 141
TC 136
Z9 142
U1 4
U2 179
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1015-8987
EI 1421-9778
J9 CELL PHYSIOL BIOCHEM
JI Cell. Physiol. Biochem.
PD SEP
PY 2015
VL 37
IS 3
BP 1029
EP 1043
DI 10.1159/000430229
PG 15
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA CT0YT
UT WOS:000362524800019
PM 26402520
OA gold, Green Accepted
DA 2023-06-08
ER

PT J
AU Lee, NY
   Yoon, SJ
   Han, DH
   Gupta, H
   Youn, GS
   Shin, MJ
   Ham, YL
   Kwak, MJ
   Kim, BY
   Yu, JS
   Lee, D
   Park, TS
   Park, SH
   Kim, BK
   Joung, HC
   Choi, IS
   Hong, JT
   Kim, DJ
   Han, SH
   Suk, KT
AF Lee, Na Young
   Yoon, Sang Jun
   Han, Dae Hee
   Gupta, Haripriya
   Youn, Gi Soo
   Shin, Min Jea
   Ham, Young Lim
   Kwak, Min Jung
   Kim, Byung Yong
   Yu, Jeong Seok
   Lee, Do Yup
   Park, Tae-Sik
   Park, Si-Hyun
   Kim, Byoung Kook
   Joung, Hyun Chae
   Choi, In Suk
   Hong, Ji Taek
   Kim, Dong Joon
   Han, Sang Hak
   Suk, Ki Tae
TI Lactobacillus and Pediococcus ameliorate progression of non-alcoholic
   fatty liver disease through modulation of the gut microbiome
SO GUT MICROBES
LA English
DT Article
DE Nonalcoholic fatty liver disease; gut liver axis; liver function;
   strains; microbiome
ID PROBIOTICS; STEATOHEPATITIS; METFORMIN; SYSTEM
AB Targeting the gut-liver axis by modulating the gut-microbiome can be a promising therapeutic approach in nonalcoholic fatty liver disease (NAFLD). The aim of this study was to evaluate the effects of single species and a combination of Lactobacillus and Pediococcus in NAFLD mice model. Six-week male C57BL/6J mice were divided into 9 groups (n = 10/group; normal, Western diet, and 7 Western diet-strains [10(9) CFU/g, 8 weeks]). The strains used were L. bulgaricus, L. casei, L. helveticus, P. pentosaceus KID7, and three combinations (1: L. casei+L. helveticus, 2: L. casei+L. helveticus+P. pentosaceus KID7, and 3: L. casei+L. helveticus+L. bulgaricus). Liver/Body weight ratio, serum and stool analysis, liver pathology, and metagenomics by 16S rRNA-sequencing were examined. In the liver/body ratio, L. bulgaricus (5.1 +/- 0.5), L. helveticus (5.2 +/- 0.4), P. pentosaceus KID7 (5.5 +/- 0.5), and combination1 and 2 (4.2 +/- 0.6 and 4.8 +/- 0.7) showed significant reductions compared with Western (6.2 +/- 0.6)(p < 0.001). In terms of cholesterol and steatosis/inflammation/NAFLD activity, all groups except for L. casei were associated with an improvement (p < .05). The elevated level of tumor necrosis factor-alpha/interleukin-1 beta (pg/ml) in Western (65.8 +/- 7.9/163.8 +/- 12.2) was found to be significantly reduced in L. bulgaricus (24.2 +/- 1.0/58.9 +/- 15.3), L. casei (35.6 +/- 2.1/62.9 +/- 6.0), L. helveticus (43.4 +/- 3.2/53.6 +/- 7.5), and P. pentosaceus KID7 (22.9 +/- 3.4/59.7 +/- 12.2)(p < 0.01). Cytokines were improved in the combination groups. In metagenomics, each strains revealed a different composition and elevated Firmicutes/Bacteroidetes ratio in the western (47.1) was decreased in L. bulgaricus (14.5), L. helveticus (3.0), and P. pentosaceus KID7 (13.3). L. bulgaricus, L. casei, L. helveticus, and P. pentosaceus KID7 supplementation can improve NAFLD-progression by modulating gut-microbiome and inflammatory pathway.
C1 [Lee, Na Young; Yoon, Sang Jun; Han, Dae Hee; Gupta, Haripriya; Youn, Gi Soo; Shin, Min Jea; Yu, Jeong Seok; Hong, Ji Taek; Kim, Dong Joon; Suk, Ki Tae] Hallym Univ, Inst Liver & Digest Dis, Chunchon, South Korea.
   [Ham, Young Lim] Daewon Univ Coll, Dept Nursing, Jaecheon, South Korea.
   [Kwak, Min Jung; Kim, Byung Yong] ChunLab Inc, Seoul, South Korea.
   [Yu, Jeong Seok] Kookmin Univ, Dept Bio & Fermentat Convergence Technol, Plus Program BK21, Seoul, South Korea.
   [Lee, Do Yup] Seoul Natl Univ, Dept Agr Biotechnol, Seoul, South Korea.
   [Park, Tae-Sik; Park, Si-Hyun] Gachon Univ, Dept Life Sci, Sungnam, South Korea.
   [Kim, Byoung Kook; Joung, Hyun Chae; Choi, In Suk] Chong Kun Dang Bio Res Inst, Ansan, Gyeonggi Do, South Korea.
   [Hong, Ji Taek; Kim, Dong Joon; Suk, Ki Tae] Hallym Univ, Dept Internal Med, Coll Med, Chunchon, South Korea.
   [Han, Sang Hak] Hallym Univ, Dept Pathol, Coll Med, Chunchon, South Korea.
C3 Hallym University; Kookmin University; Seoul National University (SNU);
   Gachon University; Hallym University; Hallym University
RP Suk, KT (通讯作者)，Hallym Univ, Chuncheon Sacred Heart Hosp, Dept Internal Med, Coll Med, Chunchon 24253, South Korea.
EM ktsuk@hallym.ac.kr
OI lee, nayoung/0000-0002-7922-4634; Youn, Gi Soo/0000-0003-3241-477X;
   Yoon, Sang Jun/0000-0003-4712-6359
FU Korea National Research Foundation [NRF-2018M3A9F3020956,
   NRF-2018M3A9F3020942]; Hallym University [HURF-2018-67]
FX This research was supported by Hallym University Research Fund, Korea
   National Research Foundation (NRF-2018M3A9F3020956 and
   NRF-2018M3A9F3020942), and Hallym University Research Fund 2018
   (HURF-2018-67).
CR Amin KA, 2011, LIPIDS HEALTH DIS, V10, DOI 10.1186/1476-511X-10-6
   Anderson RC, 2010, BMC MICROBIOL, V10, DOI 10.1186/1471-2180-10-316
   Bahl MI, 2012, FEMS MICROBIOL LETT, V329, P193, DOI 10.1111/j.1574-6968.2012.02523.x
   Brunt EM, 1999, AM J GASTROENTEROL, V94, P2467, DOI 10.1016/S0002-9270(99)00433-5
   Cats A, 2003, ALIMENT PHARM THER, V17, P429, DOI 10.1046/j.1365-2036.2003.01452.x
   Caussy C, 2017, J CLIN INVEST, V127, P2697, DOI 10.1172/JCI93465
   Chen JZ, 2019, J CELL BIOCHEM, V120, P2713, DOI 10.1002/jcb.27635
   Chen YY, 2019, TOXINS, V11, DOI 10.3390/toxins11010017
   Cho MS, 2018, J MICROBIOL, V56, P855, DOI 10.1007/s12275-018-8346-2
   Cui X, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-017-18756-2
   Damodharan K, 2015, FRONT MICROBIOL, V6, DOI 10.3389/fmicb.2015.00768
   De Santis A, 2000, AM J GASTROENTEROL, V95, P323, DOI 10.1016/S0002-9270(99)00785-6
   Edgar RC, 2010, BIOINFORMATICS, V26, P2460, DOI 10.1093/bioinformatics/btq461
   Foster KR, 2017, NATURE, V548, P43, DOI 10.1038/nature23292
   Fourie NH, 2016, GUT MICROBES, V7, P286, DOI 10.1080/19490976.2016.1162363
   Ghouri YA, 2014, CLIN EXP GASTROENTER, V7, P473, DOI 10.2147/CEG.S27530
   Hong M, 2019, PROBIOTICS ANTIMICRO, V11, P335, DOI 10.1007/s12602-018-9419-6
   Humphries C, 2017, NATURE, V550, pS12, DOI 10.1038/550S12a
   Jauhiainen T, 2010, EUR J CLIN NUTR, V64, P424, DOI 10.1038/ejcn.2010.3
   Ji DY, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-27600-0
   Ji Y, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.00710
   Jiang WW, 2015, SCI REP-UK, V5, DOI 10.1038/srep08096
   Kim DH, 2017, MOL NUTR FOOD RES, V61, DOI 10.1002/mnfr.201700252
   Kleiner DE, 2005, HEPATOLOGY, V41, P1313, DOI 10.1002/hep.20701
   Kneeman JM, 2012, THER ADV GASTROENTER, V5, P199, DOI 10.1177/1756283X11430859
   Koliada A, 2017, BMC MICROBIOL, V17, DOI 10.1186/s12866-017-1027-1
   Koutnikova H, 2019, BMJ OPEN, V9, DOI 10.1136/bmjopen-2017-017995
   Kundu P, 2017, CELL, V171, P1481, DOI 10.1016/j.cell.2017.11.024
   Lee EM, 2019, FOOD RES INT, V120, P12, DOI 10.1016/j.foodres.2019.02.021
   Li B, 2017, NUCLEIC ACIDS RES, V45, pW162, DOI 10.1093/nar/gkx449
   Li ZP, 2003, HEPATOLOGY, V37, P343, DOI 10.1053/jhep.2003.50048
   Lindheim L, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0168390
   Lirussi F, 2007, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD005165.pub2
   Ma YY, 2013, WORLD J GASTROENTERO, V19, P6911, DOI 10.3748/wjg.v19.i40.6911
   Mavrogiannaki AN, 2013, INT J ENDOCRINOL, V2013, DOI 10.1155/2013/450639
   Messaoudi M, 2011, BRIT J NUTR, V105, P755, DOI 10.1017/S0007114510004319
   Million M, 2012, MICROB PATHOGENESIS, V53, P100, DOI 10.1016/j.micpath.2012.05.007
   Mykhal'chyshyn H P, 2013, Lik Sprava, P56
   Nagata Kiyoshi, 2007, Journal of Toxicological Sciences, V32, P453, DOI 10.2131/jts.32.453
   Okubo H, 2013, AM J PHYSIOL-GASTR L, V305, pG911, DOI 10.1152/ajpgi.00225.2013
   Paolella G, 2014, WORLD J GASTROENTERO, V20, P15518, DOI 10.3748/wjg.v20.i42.15518
   Park SJ, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-018-37572-w
   Polyzos AA, 2019, CELL METAB, V29, P1258, DOI 10.1016/j.cmet.2019.03.004
   PRITCHARD GG, 1993, FEMS MICROBIOL REV, V12, P179, DOI [10.1016/0168-6445(93)90063-F, 10.1111/j.1574-6976.1993.tb00018.x]
   Rinella ME, 2015, JAMA-J AM MED ASSOC, V313, P2263, DOI 10.1001/jama.2015.5370
   Shavakhi A, 2013, INT J PREVENTIVE MED, V4, P531
   Suk KT, 2019, EXPERT REV GASTROENT, V13, P193, DOI 10.1080/17474124.2019.1569513
   Sung H, 2016, WORLD J GASTROENTERO, V22, P6673, DOI 10.3748/wjg.v22.i29.6673
   Wang ZN, 2011, NATURE, V472, P57, DOI 10.1038/nature09922
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Yoon SH, 2017, INT J SYST EVOL MICR, V67, P1613, DOI 10.1099/ijsem.0.001755
   Yoshida N, 2018, CIRCULATION, V138, P2486, DOI 10.1161/CIRCULATIONAHA.118.033714
   Yuan J, 2019, CELL METAB, V30, P675, DOI 10.1016/j.cmet.2019.08.018
NR 53
TC 56
Z9 61
U1 6
U2 42
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1949-0976
EI 1949-0984
J9 GUT MICROBES
JI Gut Microbes
PY 2020
VL 11
IS 4
DI 10.1080/19490976.2020.1712984
EA JAN 2020
PG 18
WC Gastroenterology & Hepatology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Microbiology
GA OS5WI
UT WOS:000508842600001
PM 31965894
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Tierney, BT
   Tan, YX
   Yang, Z
   Shui, B
   Walker, MJ
   Kent, BM
   Kostic, AD
   Patel, CJ
AF Tierney, Braden T.
   Tan, Yingxuan
   Yang, Zhen
   Shui, Bing
   Walker, Michaela J.
   Kent, Benjamin M.
   Kostic, Aleksandar D.
   Patel, Chirag J.
TI Systematically assessing microbiome-disease associations identifies
   drivers of inconsistency in metagenomic research
SO PLOS BIOLOGY
LA English
DT Article
ID HUMAN GUT MICROBIOME; FAECALIBACTERIUM-PRAUSNITZII;
   AKKERMANSIA-MUCINIPHILA; ENVIRONMENT; METFORMIN
AB Evaluating the relationship between the human gut microbiome and disease requires computing reliable statistical associations. Here, using millions of different association modeling strategies, we evaluated the consistency-or robustness-of microbiome-based disease indicators for 6 prevalent and well-studied phenotypes (across 15 public cohorts and 2,343 individuals). We were able to discriminate between analytically robust versus nonrobust results. In many cases, different models yielded contradictory associations for the same taxon-disease pairing, some showing positive correlations and others negative. When querying a subset of 581 microbe-disease associations that have been previously reported in the literature, 1 out of 3 taxa demonstrated substantial inconsistency in association sign. Notably, >90% of published findings for type 1 diabetes (T1D) and type 2 diabetes (T2D) were particularly nonrobust in this regard. We additionally quantified how potential confounders-sequencing depth, glucose levels, cholesterol, and body mass index, for example-influenced associations, analyzing how these variables affect the ostensible correlation between Faecalibacterium prausnitzii abundance and a healthy gut. Overall, we propose our approach as a method to maximize confidence when prioritizing findings that emerge from microbiome association studies.
C1 [Tierney, Braden T.; Tan, Yingxuan; Patel, Chirag J.] Harvard Med Sch, Dept Biomed Informat, Boston, MA 02115 USA.
   [Tierney, Braden T.; Yang, Zhen; Kostic, Aleksandar D.] Joslin Diabet Ctr, Sect Pathophysiol & Mol Pharmacol, Boston, MA 02115 USA.
   [Tierney, Braden T.; Yang, Zhen; Kostic, Aleksandar D.] Joslin Diabet Ctr, Sect Islet Cell & Regenerat Biol, Boston, MA 02115 USA.
   [Tierney, Braden T.; Yang, Zhen; Kostic, Aleksandar D.] Harvard Med Sch, Dept Microbiol & Immunobiol, Boston, MA 02115 USA.
   [Shui, Bing] Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02115 USA.
   [Walker, Michaela J.] UPSIDE Foods, Berkeley, CA USA.
   [Kent, Benjamin M.] US Marine Corps, Camp Pendleton, CA USA.
   [Tan, Yingxuan] Stanford Univ, Dept Comp Sci, Stanford, CA 94305 USA.
C3 Harvard University; Harvard Medical School; Harvard University; Joslin
   Diabetes Center, Inc.; Harvard University; Joslin Diabetes Center, Inc.;
   Harvard University; Harvard Medical School; Harvard University;
   Dana-Farber Cancer Institute; Stanford University
RP Patel, CJ (通讯作者)，Harvard Med Sch, Dept Biomed Informat, Boston, MA 02115 USA.; Kostic, AD (通讯作者)，Joslin Diabet Ctr, Sect Pathophysiol & Mol Pharmacol, Boston, MA 02115 USA.; Kostic, AD (通讯作者)，Joslin Diabet Ctr, Sect Islet Cell & Regenerat Biol, Boston, MA 02115 USA.; Kostic, AD (通讯作者)，Harvard Med Sch, Dept Microbiol & Immunobiol, Boston, MA 02115 USA.
EM Aleksandar.Kostic@joslin.harvard.edu; chirag_patel@hms.harvard.edu
OI Shui, Bing/0000-0002-5956-130X; Yang, Zhen/0000-0001-6057-6958; Tan,
   Yingxuan/0000-0001-6674-3219
FU National Science Foundation [1636870]; National Institute of Allergy and
   Infectious Diseases [R01AI127250]; National Institute of Health Sciences
   [R01ES032470]; American Diabetes Association Pathway to Stop Diabetes
   Initiator Award [1-17-INI-13]; Smith Family Foundation Award for
   Excellence in Biomedical Research; Office of Advanced
   Cyberinfrastructure (OAC); Direct For Computer & Info Scie & Enginr
   [1636870] Funding Source: National Science Foundation
FX CJP and BTT were funded by the National Science Foundation (#1636870),
   the National Institute of Allergy and Infectious Diseases (R01AI127250),
   and the National Institute of Health Sciences (R01ES032470). ADK was
   funded by an American Diabetes Association Pathway to Stop Diabetes
   Initiator Award (#1-17-INI-13) and the Smith Family Foundation Award for
   Excellence in Biomedical Research. The funders had no role in study
   design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
CR Abubucker S, 2017, HUMANN2 HMP UNIFIED
   Armitage P, 2003, INT J EPIDEMIOL, V32, P925, DOI 10.1093/ije/dyg286
   BARON RM, 1986, J PERS SOC PSYCHOL, V51, P1173, DOI 10.1037/0022-3514.51.6.1173
   Bolyen E, 2019, NAT BIOTECHNOL, V37, P852, DOI 10.1038/s41587-019-0209-9
   Chu LZ, 2020, INT J EPIDEMIOL, V49, P608, DOI 10.1093/ije/dyz271
   Duvallet C, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-01973-8
   El-Semman IE, 2014, BMC SYST BIOL, V8, DOI 10.1186/1752-0509-8-41
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Ferreira-Halder CV, 2017, BEST PRACT RES CL GA, V31, P643, DOI 10.1016/j.bpg.2017.09.011
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Forstmeier W, 2017, BIOL REV, V92, P1941, DOI 10.1111/brv.12315
   Fragoso TM., BAYESIAN MODEL AVERA
   Gevers D, 2014, CELL HOST MICROBE, V15, P382, DOI 10.1016/j.chom.2014.02.005
   Ghosh TS, 2020, ELIFE, V9, DOI 10.7554/eLife.50240
   Gilbert JA, 2016, GUT, V65, P1, DOI 10.1136/gutjnl-2015-310043
   Goodman SN, 2016, SCI TRANSL MED, V8, DOI 10.1126/scitranslmed.aaf5027
   Hannigan GD, 2018, MBIO, V9, DOI 10.1128/mBio.02248-18
   Harder JA, 2020, PERSPECT PSYCHOL SCI, V15, P1158, DOI 10.1177/1745691620917678
   HILL AB, 1965, P ROY SOC MED, V58, P295, DOI 10.1177/003591576505800503
   Hofler M, 2005, BMC Med Res Methodol, V5, P28, DOI 10.1186/1471-2288-5-28
   Ioannidis JPA, 2016, STAT MED, V35, P1749, DOI 10.1002/sim.6825
   Ioannidis JPA, 2011, EPIDEMIOLOGY, V22, P450, DOI 10.1097/EDE.0b013e31821b506e
   Kim D, 2017, MICROBIOME, V5, DOI 10.1186/s40168-017-0267-5
   Klau S, 2021, INT J EPIDEMIOL, V50, P266, DOI 10.1093/ije/dyaa164
   Kostic AD, 2012, GENOME RES, V22, P292, DOI 10.1101/gr.126573.111
   Le Goallec A, 2020, PLOS COMPUT BIOL, V16, DOI 10.1371/journal.pcbi.1007895
   Lloyd-Price J, 2019, NATURE, V569, P655, DOI 10.1038/s41586-019-1237-9
   Loomba R, 2017, CELL METAB, V25, P1054, DOI 10.1016/j.cmet.2017.04.001
   Mardinoglu A, 2016, CELL METAB, V23, P10, DOI 10.1016/j.cmet.2015.12.012
   Miquel S, 2013, CURR OPIN MICROBIOL, V16, P255, DOI 10.1016/j.mib.2013.06.003
   Moossavi S, 2021, MICROBIOME, V9, DOI 10.1186/s40168-020-00998-4
   Nearing J.T., 2021, BIOINFORMATICS, DOI DOI 10.1101/2021.05.10.443486
   Nearing JT, 2022, NAT COMMUN, V13, DOI 10.1038/s41467-022-28034-z
   Palpacuer C, 2019, BMC MED, V17, DOI 10.1186/s12916-019-1409-3
   Parsonnet J, 1997, GUT, V40, P297, DOI 10.1136/gut.40.3.297
   Pasolli E, 2017, NAT METHODS, V14, P1023, DOI 10.1038/nmeth.4468
   Patel CJ, 2015, J CLIN EPIDEMIOL, V68, P1046, DOI 10.1016/j.jclinepi.2015.05.029
   Qin N, 2014, NATURE, V513, P59, DOI 10.1038/nature13568
   Remely M, 2016, ENDOCR METAB IMMUNE, V16, P99, DOI 10.2174/1871530316666160831093813
   Rothschild D, 2018, NATURE, V555, P210, DOI 10.1038/nature25973
   Schloss PD, 2018, MBIO, V9, DOI 10.1128/mBio.00525-18
   Siljander H, 2019, EBIOMEDICINE, V46, P512, DOI 10.1016/j.ebiom.2019.06.031
   Sokol H, 2009, INFLAMM BOWEL DIS, V15, P1183, DOI 10.1002/ibd.20903
   Steegen S, 2016, PERSPECT PSYCHOL SCI, V11, P702, DOI 10.1177/1745691616658637
   Sze MA, 2016, MBIO, V7, DOI 10.1128/mBio.01018-16
   Tierney BT, 2021, PLOS BIOL, V19, DOI 10.1371/journal.pbio.3001398
   Tierney BT, 2021, NAT COMMUN, V12, DOI 10.1038/s41467-021-23029-8
   Viechtbauer W, 2010, J STAT SOFTW, V36, P1, DOI 10.18637/jss.v036.i03
   Vieira-Silva S, 2020, NATURE, V581, P310, DOI 10.1038/s41586-020-2269-x
   Vujkovic-Cvijin I, 2020, NATURE, V587, P448, DOI 10.1038/s41586-020-2881-9
   Wickham H, 2009, USE R, P1, DOI 10.1007/978-0-387-98141-3_1
   Wirbel J, 2019, NAT MED, V25, P679, DOI 10.1038/s41591-019-0406-6
NR 52
TC 4
Z9 5
U1 2
U2 8
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1544-9173
EI 1545-7885
J9 PLOS BIOL
JI PLoS. Biol.
PD MAR
PY 2022
VL 20
IS 3
AR e3001556
DI 10.1371/journal.pbio.3001556
PG 18
WC Biochemistry & Molecular Biology; Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics
GA 0A8KQ
UT WOS:000774196600002
PM 35235560
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Huda, MN
   Kim, M
   Bennett, BJ
AF Huda, M. Nazmul
   Kim, Myungsuk
   Bennett, Brian J.
TI Modulating the Microbiota as a Therapeutic Intervention for Type 2
   Diabetes
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE microbiota (16S); type 2 diabetes (T2D); metabolites; probiotics;
   prebioitcs; intermittent fasting; genetics; epigenetics
ID TRIMETHYLAMINE-N-OXIDE; GUT MICROBIOTA; AKKERMANSIA-MUCINIPHILA; INSULIN
   SENSITIVITY; BILE-ACIDS; GLUCOSE; METABOLISM; METFORMIN; BACTERIA; DIET
AB Mounting evidence suggested that the gut microbiota has a significant role in the metabolism and disease status of the host. In particular, Type 2 Diabetes (T2D), which has a complex etiology that includes obesity and chronic low-grade inflammation, is modulated by the gut microbiota and microbial metabolites. Current literature supports that unbalanced gut microbial composition (dysbiosis) is a risk factor for T2D. In this review, we critically summarize the recent findings regarding the role of gut microbiota in T2D. Beyond these associative studies, we focus on the causal relationship between microbiota and T2D established using fecal microbiota transplantation (FMT) or probiotic supplementation, and the potential underlying mechanisms such as byproducts of microbial metabolism. These microbial metabolites are small molecules that establish communication between microbiota and host cells. We critically summarize the associations between T2D and microbial metabolites such as short-chain fatty acids (SCFAs) and trimethylamine N-Oxide (TMAO). Additionally, we comment on how host genetic architecture and the epigenome influence the microbial composition and thus how the gut microbiota may explain part of the missing heritability of T2D found by GWAS analysis. We also discuss future directions in this field and how approaches such as FMT, prebiotics, and probiotics supplementation are being considered as potential therapeutics for T2D.
C1 [Huda, M. Nazmul; Kim, Myungsuk; Bennett, Brian J.] Univ Calif Davis, Dept Nutr, Davis, CA 95616 USA.
   [Huda, M. Nazmul; Kim, Myungsuk; Bennett, Brian J.] ARS, Obes & Metab Res Unit, USDA, Western Human Nutr Res Ctr, Davis, CA 95616 USA.
C3 University of California System; University of California Davis; United
   States Department of Agriculture (USDA)
RP Bennett, BJ (通讯作者)，Univ Calif Davis, Dept Nutr, Davis, CA 95616 USA.; Bennett, BJ (通讯作者)，ARS, Obes & Metab Res Unit, USDA, Western Human Nutr Res Ctr, Davis, CA 95616 USA.
EM brian.bennett@usda.gov
RI Huda, M. Nazmul/AAW-1398-2021; Kim, Myungsuk/GYD-6322-2022
OI Huda, M. Nazmul/0000-0003-2775-4470; Kim, Myungsuk/0000-0002-5618-3040
FU NIH [5R01HL128572]; NIFA [2019-07731]; USDA project [2032-51530-025-00D]
FX This research was supported in part by NIH grant 5R01HL128572 (BB), NIFA
   grant 2019-07731 (BB) and USDA project 2032-51530-025-00D (BB). The USDA
   is an equal-opportunity employer.
CR Adeshirlarijaney A, 2019, AM J PHYSIOL-ENDOC M, V317, pE1121, DOI 10.1152/ajpendo.00245.2019
   Anson RM, 2003, P NATL ACAD SCI USA, V100, P6216, DOI 10.1073/pnas.1035720100
   Ardlie KG, 2015, SCIENCE, V348, P648, DOI 10.1126/science.1262110
   Atarashi K, 2013, NATURE, V500, P232, DOI 10.1038/nature12331
   Backhed F, 2004, P NATL ACAD SCI USA, V101, P15718, DOI 10.1073/pnas.0407076101
   Baur JA, 2014, CELL METAB, V20, P197, DOI 10.1016/j.cmet.2014.07.013
   Bennett BJ, 2013, CELL METAB, V17, P49, DOI 10.1016/j.cmet.2012.12.011
   Berg G, 2020, MICROBIOME, V8, DOI 10.1186/s40168-020-00875-0
   Berry SE, 2020, NAT MED, V26, P964, DOI 10.1038/s41591-020-0934-0
   Birkeland E, 2020, EUR J NUTR, V59, P3325, DOI 10.1007/s00394-020-02282-5
   Bloomgarden Z, 2018, J DIABETES, V10, P350, DOI 10.1111/1753-0407.12645
   Bock PM, 2021, DIABETOLOGIA, V64, P26, DOI 10.1007/s00125-020-05295-1
   Bolduc JF, 2017, J VIROL, V91, DOI 10.1128/JVI.01943-16
   BONORA E, 1984, CURR MED RES OPIN, V9, P47, DOI 10.1185/03007998409109558
   Brandhorst S, 2015, CELL METAB, V22, P86, DOI 10.1016/j.cmet.2015.05.012
   Cani PD, 2007, DIABETOLOGIA, V50, P2374, DOI 10.1007/s00125-007-0791-0
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Cani PD, 2004, BRIT J NUTR, V92, P521, DOI 10.1079/BJN20041225
   Chang YC, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0180025
   Chen ML, 2016, MBIO, V7, DOI 10.1128/mBio.02210-15
   Chen P, 2014, NUTRITION, V30, P1061, DOI 10.1016/j.nut.2014.03.022
   Chen PB, 2020, NAT BIOTECHNOL, V38, P1288, DOI 10.1038/s41587-020-0549-5
   Chen XP, 2015, J DIABETES INVEST, V6, P369, DOI 10.1111/jdi.12345
   Chiang JYL, 2009, J LIPID RES, V50, P1955, DOI 10.1194/jlr.R900010-JLR200
   Chimerel C, 2014, CELL REP, V9, P1202, DOI 10.1016/j.celrep.2014.10.032
   Coady MJ, 2002, J BIOL CHEM, V277, P35219, DOI 10.1074/jbc.M204321200
   Cohen LJ, 2017, NATURE, V549, P48, DOI 10.1038/nature23874
   Control CfD Prevention, 2020, NAT DIAB STAT REP 20
   Dagdeviren S, 2017, FASEB J, V31, P701, DOI 10.1096/fj.201600832R
   Dambrova M, 2016, EXP CLIN ENDOCR DIAB, V124, P251, DOI 10.1055/s-0035-1569330
   Davie JR, 2003, J NUTR, V133, p2485S, DOI 10.1093/jn/133.7.2485S
   Dayeh T, 2014, PLOS GENET, V10, DOI 10.1371/journal.pgen.1004160
   de Cabo R, 2019, NEW ENGL J MED, V381, P2541, DOI 10.1056/NEJMra1905136
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Depommier C, 2019, NAT MED, V25, P1096, DOI 10.1038/s41591-019-0495-2
   Dodd D, 2017, NATURE, V551, P648, DOI 10.1038/nature24661
   Doumatey AP, 2020, FRONT CELL INFECT MI, V10, DOI 10.3389/fcimb.2020.00063
   Ejtahed HS, 2019, EUR J ENDOCRINOL, V180, P165, DOI [10.1530/EJE-18-0826, 10.1530/eje-18-0826]
   El-Mir MY, 2000, J BIOL CHEM, V275, P223, DOI 10.1074/jbc.275.1.223
   Everard A, 2014, REV ENDOCR METAB DIS, V15, P189, DOI 10.1007/s11154-014-9288-6
   Fang S, 2015, NAT MED, V21, P159, DOI 10.1038/nm.3760
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Fuchsberger C, 2016, NATURE, V536, P41, DOI 10.1038/nature18642
   Furet JP, 2010, DIABETES, V59, P3049, DOI 10.2337/db10-0253
   Furusawa Y, 2013, NATURE, V504, P446, DOI 10.1038/nature12721
   Gao X, 2014, J BIOSCI BIOENG, V118, P476, DOI 10.1016/j.jbiosc.2014.03.001
   Gerard P, 2014, PATHOGENS, V3, P14, DOI 10.3390/pathogens3010014
   GIBSON GR, 1995, J NUTR, V125, P1401, DOI 10.1093/jn/125.6.1401
   Goodrich JK, 2016, CELL HOST MICROBE, V19, P731, DOI 10.1016/j.chom.2016.04.017
   Goodrich JK, 2014, CELL, V159, P789, DOI 10.1016/j.cell.2014.09.053
   Gu YY, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-01682-2
   Gulden E, 2018, CURR DIABETES REP, V18, DOI 10.1007/s11892-018-1098-x
   Gurung M, 2020, EBIOMEDICINE, V51, DOI 10.1016/j.ebiom.2019.11.051
   Hamer HM, 2008, ALIMENT PHARM THER, V27, P104, DOI 10.1111/j.1365-2036.2007.03562.x
   Hatori M, 2012, CELL METAB, V15, P848, DOI 10.1016/j.cmet.2012.04.019
   Hirasawa A, 2008, BIOL PHARM BULL, V31, P1847, DOI 10.1248/bpb.31.1847
   Hoffmann TW, 2016, ISME J, V10, P460, DOI 10.1038/ismej.2015.127
   Holst JJ, 2007, PHYSIOL REV, V87, P1409, DOI 10.1152/physrev.00034.2006
   Hove KD, 2015, EUR J ENDOCRINOL, V172, DOI 10.1530/EJE-14-0554
   Hughes DA, 2020, NAT MICROBIOL, V5, P1079, DOI 10.1038/s41564-020-0743-8
   IDF, 2019, IDF DIABETES ATLAS, V2019
   Jia JZ, 2019, DIABETES, V68, P1747, DOI 10.2337/db19-0153
   Jia W, 2018, NAT REV GASTRO HEPAT, V15, P111, DOI 10.1038/nrgastro.2017.119
   Johnson AJ, 2019, CELL HOST MICROBE, V25, P789, DOI 10.1016/j.chom.2019.05.005
   Ju F, 2015, APPL MICROBIOL BIOT, V99, P4119, DOI 10.1007/s00253-015-6536-y
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kasinska MA, 2015, POL ARCH MED WEWN, V125, P803, DOI 10.20452/pamw.3156
   Kassam Z, 2013, AM J GASTROENTEROL, V108, P500, DOI 10.1038/ajg.2013.59
   Katsuma S, 2005, BIOCHEM BIOPH RES CO, V329, P386, DOI 10.1016/j.bbrc.2005.01.139
   Kechagia Maria, 2013, ISRN Nutr, V2013, P481651, DOI 10.5402/2013/481651
   Khoruts A, 2016, NAT REV GASTRO HEPAT, V13, DOI 10.1038/nrgastro.2016.98
   Kim YA, 2018, NUTR RES REV, V31, P35, DOI 10.1017/S095442241700018X
   Koeth RA, 2013, NAT MED, V19, P576, DOI 10.1038/nm.3145
   Koh A, 2020, CELL METAB, V32, P643, DOI 10.1016/j.cmet.2020.07.012
   Koh A, 2018, CELL, V175, P947, DOI 10.1016/j.cell.2018.09.055
   Kootte RS, 2017, CELL METAB, V26, P611, DOI 10.1016/j.cmet.2017.09.008
   Krautkramer KA, 2016, MOL CELL, V64, P982, DOI 10.1016/j.molcel.2016.10.025
   Kuka J, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-71470-4
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Lee KTY, 2011, ENDOCRINOLOGY, V152, P3005, DOI 10.1210/en.2011-0060
   Lee YS, 2018, CELL, V172, P22, DOI 10.1016/j.cell.2017.12.025
   Ley RE, 2005, P NATL ACAD SCI USA, V102, P11070, DOI 10.1073/pnas.0504978102
   Ley RE, 2006, NATURE, V444, P1022, DOI 10.1038/4441022a
   Li K, 2019, FOOD FUNCT, V10, P1915, DOI 10.1039/c8fo02265h
   Li Q, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-62224-3
   Li X, 2016, J APPL MICROBIOL, V121, P1727, DOI 10.1111/jam.13276
   Liu WC, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0196511
   Liu ZG, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-14676-4
   Macia L, 2012, IMMUNOL REV, V245, P164, DOI 10.1111/j.1600-065X.2011.01080.x
   Mahboobi S, 2018, ADV PHARM BULL, V8, P565, DOI 10.15171/apb.2018.065
   Maher B, 2008, NATURE, V456, P18, DOI 10.1038/456018a
   Malik F, 2018, DIABETES-METAB RES, V34, DOI 10.1002/dmrr.2975
   Mandaliya DK, 2019, PANCREATOLOGY, V19, P280, DOI 10.1016/j.pan.2019.01.021
   Markowiak P, 2017, NUTRIENTS, V9, DOI 10.3390/nu9091021
   McCreight LJ, 2016, DIABETOLOGIA, V59, P426, DOI 10.1007/s00125-015-3844-9
   McRorie JW, 2017, EUR J CLIN NUTR, V71, P677, DOI 10.1038/ejcn.2017.15
   Mell B, 2015, PHYSIOL GENOMICS, V47, P187, DOI 10.1152/physiolgenomics.00136.2014
   Morrison DJ, 2016, GUT MICROBES, V7, P189, DOI 10.1080/19490976.2015.1134082
   Morshedi M, 2020, J TRANSL MED, V18, DOI 10.1186/s12967-019-02169-y
   Mutaguchi Y, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.01540
   Naderpoor N, 2019, J CLIN MED, V8, DOI 10.3390/jcm8040452
   Huda MN, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-63214-1
   Nazzaro F, 2012, ANAEROBE, V18, P280, DOI 10.1016/j.anaerobe.2012.03.002
   Newgard CB, 2009, CELL METAB, V9, P311, DOI 10.1016/j.cmet.2009.02.002
   Oh TG, 2020, CELL METAB, V32, P878, DOI 10.1016/j.cmet.2020.06.005
   Parnell JA, 2009, AM J CLIN NUTR, V89, P1751, DOI 10.3945/ajcn.2009.27465
   Pedersen HK, 2016, NATURE, V535, P376, DOI 10.1038/nature18646
   Peng J, 2014, J AUTOIMMUN, V53, P85, DOI 10.1016/j.jaut.2014.03.005
   Plovier H, 2017, NAT MED, V23, P107, DOI 10.1038/nm.4236
   Qi JQ, 2018, J CELL MOL MED, V22, P185, DOI 10.1111/jcmm.13307
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Qin YF, 2018, J BIOCHEM, V163, P105, DOI 10.1093/jb/mvx080
   Ramos-Molinau B, 2019, FRONT GENET, V10, DOI 10.3389/fgene.2019.00613
   Rathinam VAK, 2019, NAT IMMUNOL, V20, P527, DOI 10.1038/s41590-019-0368-3
   Roager HM, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-018-05470-4
   Roberfroid MB, 2005, BRIT J NUTR, V93, pS13, DOI 10.1079/BJN20041350
   Rodriguez J, 2018, CURR OPIN CLIN NUTR, V21, P294, DOI 10.1097/MCO.0000000000000468
   Rosario D, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.00775
   Ross SA, 2010, CAN FAM PHYSICIAN, V56, P639
   Salamon D, 2018, POL ARCH INTERN MED, V128, P336, DOI 10.20452/pamw.4246
   Sato J, 2014, DIABETES CARE, V37, P2343, DOI 10.2337/dc13-2817
   SAVAGE DC, 1977, ANNU REV MICROBIOL, V31, P107, DOI 10.1146/annurev.mi.31.100177.000543
   Schrezenmeir J, 2001, AM J CLIN NUTR, V73, p361S, DOI 10.1093/ajcn/73.2.361s
   Scott KP, 2013, PHARMACOL RES, V69, P52, DOI 10.1016/j.phrs.2012.10.020
   Sekirov I, 2010, PHYSIOL REV, V90, P859, DOI 10.1152/physrev.00045.2009
   Sharma P, 2016, INT J PREVENTIVE MED, V7, DOI 10.4103/2008-7802.188870
   Shen ZH, 2018, J GASTROEN HEPATOL, V33, P1751, DOI 10.1111/jgh.14144
   Shi H, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.02716
   Shih DM, 2015, J LIPID RES, V56, P22, DOI 10.1194/jlr.M051680
   Sircana A, 2018, CURR DIABETES REP, V18, DOI 10.1007/s11892-018-1057-6
   Smits LP, 2018, J AM HEART ASSOC, V7, DOI 10.1161/JAHA.117.008342
   So JS, 2008, MOL IMMUNOL, V45, P2690, DOI 10.1016/j.molimm.2007.12.010
   Spinner JA, 2020, PEDIATR TRANSPLANT, V24, DOI 10.1111/petr.13598
   Su BL, 2015, J DIABETES, V7, P729, DOI 10.1111/1753-0407.12232
   Tang WHW, 2017, CLIN CHEM, V63, P297, DOI 10.1373/clinchem.2016.263640
   Thaiss CA, 2016, NATURE, V540, P544, DOI 10.1038/nature20796
   Thomas Torsten, 2012, Microb Inform Exp, V2, P3, DOI 10.1186/2042-5783-2-3
   Tian PJ, 2016, FOOD FUNCT, V7, P3789, DOI [10.1039/c6fo00831c, 10.1039/C6FO00831C]
   Tilg H, 2020, NAT REV IMMUNOL, V20, P40, DOI 10.1038/s41577-019-0198-4
   Torres LE, 2009, WORLD J GASTROENTERO, V15, P204, DOI 10.3748/wjg.15.204
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Venkatesh M, 2014, IMMUNITY, V41, P296, DOI 10.1016/j.immuni.2014.06.014
   Verhoog S, 2019, NUTRIENTS, V11, DOI 10.3390/nu11071565
   Vijayan A, 2018, TRENDS MICROBIOL, V26, P423, DOI 10.1016/j.tim.2017.10.008
   Villarini M, 2008, ENVIRON MOL MUTAGEN, V49, P192, DOI 10.1002/em.20367
   Wang JJ, 2020, J DIABETES RES, V2020, DOI 10.1155/2020/6047145
   Wang L., 2016, SCI REP-UK, V6, P33251, DOI [10.1038/srep33251, DOI 10.1038/srep33251]
   Wang TJ, 2011, NAT MED, V17, P448, DOI 10.1038/nm.2307
   Wang XT, 2014, NATURE, V514, P237, DOI 10.1038/nature13564
   Wang ZN, 2011, NATURE, V472, P57, DOI 10.1038/nature09922
   Watson MM, 2017, HANDBOOK OF EPIGENETICS: THE NEW MOLECULAR AND MEDICAL GENETICS, 2ND EDITION, P495, DOI 10.1016/B978-0-12-805388-1.00032-8
   Wei SY, 2018, NUTR METAB, V15, DOI 10.1186/s12986-018-0318-3
   Wolf AJ, 2018, NAT REV IMMUNOL, V18, P243, DOI 10.1038/nri.2017.136
   Wu GD, 2016, GUT, V65, P63, DOI 10.1136/gutjnl-2014-308209
   Wu H, 2020, CELL METAB, V32, P379, DOI 10.1016/j.cmet.2020.06.011
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Yun SI, 2009, J APPL MICROBIOL, V107, P1681, DOI 10.1111/j.1365-2672.2009.04350.x
   Zarrinpar A, 2014, CELL METAB, V20, P1006, DOI 10.1016/j.cmet.2014.11.008
   Zhang CH, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms3163
   Zhang L, 2018, PATHOG DIS, V76, DOI 10.1093/femspd/fty028
   Zhang PP, 2020, ACTA PHARMACOL SIN, V41, P678, DOI 10.1038/s41401-019-0330-9
   Zhang Q, 2018, EXP BIOL MED, V243, P34, DOI 10.1177/1535370217743765
   Zhang XY, 2017, DIABETES THER, V8, P293, DOI 10.1007/s13300-017-0226-y
   Zhang XY, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0071108
   Zhang YF, 2008, J CLIN ENDOCR METAB, V93, P2559, DOI 10.1210/jc.2007-2404
   Zhang YF, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-18414-8
   Zhao LP, 2018, SCIENCE, V359, P1151, DOI 10.1126/science.aao5774
   Zhou GC, 2001, J CLIN INVEST, V108, P1167, DOI 10.1172/JCI200113505
   Zhou HP, 2014, STEROIDS, V86, P62, DOI 10.1016/j.steroids.2014.04.016
   Zhou LX, 2018, INFLAMM BOWEL DIS, V24, P1926, DOI 10.1093/ibd/izy182
   Zhu SJ, 2020, CURR OPIN CLIN NUTR, V23, P387, DOI 10.1097/MCO.0000000000000694
   Zhuang RL, 2019, OBES REV, V20, P883, DOI 10.1111/obr.12843
NR 173
TC 34
Z9 34
U1 3
U2 31
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD APR 7
PY 2021
VL 12
AR 632335
DI 10.3389/fendo.2021.632335
PG 17
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA RQ0CN
UT WOS:000642088000001
PM 33897618
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Lee, H
   Kim, J
   An, J
   Lee, S
   Kong, H
   Song, Y
   Choi, HR
   Lee, SJ
   Chae, KS
   Kwon, JW
   Kim, K
AF Lee, Heetae
   Kim, Jiyeon
   An, Jinho
   Lee, Sungwon
   Kong, Hyunseok
   Song, Youngcheon
   Choi, Hye Ran
   Lee, Su Jung
   Chae, Kyu Seo
   Kwon, Ji Wung
   Kim, Kyungjae
TI Amelioration of hyperglycemia by Rubus occidentalis (black raspberry)
   and increase in short-chain fatty acids producing bacteria
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Rubus occidentalis (RO); Black raspberry; Gut microbiota; Short-chain
   fatty acids; Hyperglycemia
ID DIET-INDUCED OBESITY; GUT MICROBIOTA; INSULIN-RESISTANCE; EXTRACT;
   IMPACT; METFORMIN; PROFILES
AB Increasing evidence suggests that gut microbiota play an important role in metabolic disorders. Rubus occidentalis (RO) (black raspberry) has antioxidant and anti-inflammatory effects and improves metabolic disorders such as hypertension and insulin resistance. This study investigated the composition of gut microbiota in RO-treated mice using an aged mouse model of high-fat diet-induced obesity. RO significantly improved mouse glucose profiles, including serum glucose levels and intraperitoneal glucose tolerance test results. RO treatment caused significant increases in the relative abundance of various genera including Bacteroides, Butyricimonas, Mucispirillum, and Ruminococcus. Moreover, these increased genera correlated with the glucose profiles. Our findings suggest that the effect of RO on glucose control is associated with an increase in short-chain fatty acids producing bacteria.
C1 [Lee, Heetae; Kim, Jiyeon; An, Jinho; Lee, Sungwon; Kong, Hyunseok; Song, Youngcheon; Kim, Kyungjae] Sahmyook Univ, Coll Pharm, Seoul 01795, South Korea.
   [Choi, Hye Ran; Lee, Su Jung; Chae, Kyu Seo; Kwon, Ji Wung] Berry & Biofood Res Inst, Jeonbuk 56417, South Korea.
C3 Sahmyook University
RP Kong, H (通讯作者)，Sahmyook Univ, Coll Pharm, Seoul 01795, South Korea.
EM hskong0813@gmail.com
OI Kong, Hyunseok/0000-0002-4880-6340
FU Korea Institute of Planning & Evaluation for Technology in Food,
   Agriculture, Forestry and Fisheries (iPET) [314044-3]
FX This work was supported by Korea Institute of Planning & Evaluation for
   Technology in Food, Agriculture, Forestry and Fisheries (iPET)
   (314044-3).
CR An JH, 2016, PHYTOTHER RES, V30, P1634, DOI 10.1002/ptr.5664
   Anhe FF, 2015, GUT, V64, P872, DOI 10.1136/gutjnl-2014-307142
   Batista AG, 2017, MOL NUTR FOOD RES, V61, DOI 10.1002/mnfr.201600952
   Blumberg JB, 2016, ADV NUTR, V7, p759S, DOI 10.3945/an.116.012583
   Caporaso JG, 2010, NAT METHODS, V7, P335, DOI 10.1038/nmeth.f.303
   Chen F, 2016, J ETHNOPHARMACOL, V179, P253, DOI 10.1016/j.jep.2015.12.031
   Chen YW, 2017, MICROBIOME, V5, DOI 10.1186/s40168-017-0232-3
   Chiu CM, 2014, BIOMED RES INT, V2014, DOI 10.1155/2014/906168
   Clarke SF, 2012, GUT MICROBES, V3, P186, DOI 10.4161/gmic.20168
   Derrien M, 2004, INT J SYST EVOL MICR, V54, P1469, DOI 10.1099/ijs.0.02873-0
   Ejtahed HS, 2016, HORM METAB RES, V48, P349, DOI 10.1055/s-0042-107792
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Firdous SM, 2014, EXCLI J, V13, P451
   Cano PG, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0041079
   Gerard P, 2007, APPL ENVIRON MICROB, V73, P5742, DOI 10.1128/AEM.02806-06
   Gilbert JA, 2010, STAND GENOMIC SCI, V3, P249, DOI [10.4056/aigs.1443528, 10.4056/sigs.1433550]
   Jakobsdottir G, 2013, J NUTR METAB, V2013, DOI 10.1155/2013/202534
   Jeong HS, 2016, NUTRITION, V32, P461, DOI 10.1016/j.nut.2015.10.014
   Jeong HS, 2014, PHYTOTHER RES, V28, P1492, DOI 10.1002/ptr.5154
   Jia LL, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-07335-0
   Joung Hyojee, 2012, Korean J Pediatr, V55, P128, DOI 10.3345/kjp.2012.55.4.128
   Kasubuchi M, 2015, NUTRIENTS, V7, P2839, DOI 10.3390/nu7042839
   Kim J, 2018, NUTRIENTS, V10, DOI 10.3390/nu10121846
   Kinross JM, 2011, GENOME MED, V3, DOI 10.1186/gm228
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Lee J, 2014, MOLECULES, V19, P10524, DOI 10.3390/molecules190710524
   Lee Y, 2017, BIOMOL THER, V25, P140, DOI 10.4062/biomolther.2016.052
   Leite AZ, 2017, FRONT IMMUNOL, V8, DOI 10.3389/fimmu.2017.01107
   Loy A, 2017, MSYSTEMS, V2, DOI 10.1128/mSystems.00171-16
   Marques C, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-29744-5
   Moreno-Indias I, 2016, AM J TRANSL RES, V8, P5672
   Morrison DJ, 2016, GUT MICROBES, V7, P189, DOI 10.1080/19490976.2015.1134082
   Piwowarski JP, 2014, J ETHNOPHARMACOL, V155, P801, DOI 10.1016/j.jep.2014.06.032
   Puddu Alessandra, 2014, Mediators Inflamm, V2014, P162021, DOI 10.1155/2014/162021
   Puupponen-Pimia R, 2013, MOL NUTR FOOD RES, V57, P2258, DOI 10.1002/mnfr.201300280
   Rios-Covian D, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.00376
   Robinson LE, 2004, CAN J APPL PHYSIOL, V29, P808, DOI 10.1139/h04-053
   Rosenbaum M, 2015, TRENDS ENDOCRIN MET, V26, P493, DOI 10.1016/j.tem.2015.07.002
   Sardo CL, 2016, AM J THER, V23, pE86, DOI 10.1097/MJT.0b013e3182a40bf8
   Segata N, 2011, GENOME BIOL, V12, DOI 10.1186/gb-2011-12-6-r60
   Shin D, 2018, ITAL J FOOD SCI, V30, P428
   Stull AJ, 2016, ANTIOXIDANTS-BASEL, V5, DOI 10.3390/antiox5040044
   Turnbaugh PJ, 2008, CELL HOST MICROBE, V3, P213, DOI 10.1016/j.chom.2008.02.015
   Vendrame S, 2016, ANTIOXIDANTS-BASEL, V5, DOI 10.3390/antiox5040034
   Wang HL, 2017, FOOD CHEM, V217, P773, DOI 10.1016/j.foodchem.2016.09.002
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Xiong T, 2020, SENSOR ACTUAT B-CHEM, V304, DOI [10.1126/scitranslmed.3009124, 10.1016/j.snb.2019.127310]
   Yoo JY, 2016, NUTRIENTS, V8, DOI 10.3390/nu8030173
   Zhang XQ, 2015, SCI REP-UK, V5, DOI 10.1038/srep10737
   김이선, 2014, [Journal of the Korean Society of Food Science and Nutrition, 한국식품영양과학회지], V43, P1357
   김진경, 2007, [Korean Journal of Food Science and Technology, 한국식품과학회지], V39, P342
NR 51
TC 19
Z9 19
U1 0
U2 12
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD MAR
PY 2019
VL 54
BP 433
EP 439
DI 10.1016/j.jff.2019.01.045
PG 7
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA HQ8RN
UT WOS:000462693100046
DA 2023-06-08
ER

PT J
AU Kitten, AK
   Ryan, L
   Lee, GC
   Flores, BE
   Reveles, KR
AF Kitten, Amanda K.
   Ryan, Laurajo
   Lee, Grace C.
   Flores, Bertha E.
   Reveles, Kelly R.
TI Gut microbiome differences among Mexican Americans with and without type
   2 diabetes mellitus
SO PLOS ONE
LA English
DT Article
ID METAGENOME; METFORMIN
AB Purpose Type 2 diabetes mellitus (T2DM) is an urgent public health problem and disproportionately affects Mexican Americans. The gut microbiome contributes to the pathophysiology of diabetes; however, no studies have examined this association in Mexican-Americans. The objective of this study was to compare gut microbiome composition between Mexican-Americans with and without T2DM.
   Methods This was a cross-sectional study of volunteers from San Antonio, TX. Subjects were 18 years or older and self-identified as Mexican American. Subjects were grouped by prior T2DM diagnosis. Eligible subjects attended a clinic visit to provide demographic and medical information. Thereafter, subjects recorded their dietary intake for three days and collected a stool sample on the fourth day. Stool 16s rRNA sequences were classified into operational taxonomic units (OTUs) via the mothur bayesian classifier and referenced to the Greengenes database. Shannon diversity and bacterial taxa relative abundance were compared between groups using the Wilcoxon rank sum test. Beta diversity was estimated using Bray-Curtis indices and compared between groups using PERMANOVA.
   Results Thirty-seven subjects were included, 14 (38%) with diabetes and 23 (62%) without diabetes. Groups were well-matched by body mass index and comorbid conditions. Shannon diversity was not significantly different between those with and without T2DM (3.26 vs. 3.31; p = 0.341). Beta diversity was not significantly associated with T2DM diagnosis (p = 0.201). The relative abundance of the most common bacterial phyla and families did not significantly differ between groups; however, 16 OTUs were significantly different between groups.
   Conclusions Although alpha diversity was not significantly different between diabetic and non-diabetic Mexican Americans, the abundance of certain bacterial taxa were significantly different between groups.
C1 [Kitten, Amanda K.; Ryan, Laurajo; Lee, Grace C.; Reveles, Kelly R.] Univ Texas Austin, Coll Pharm, Austin, TX 78712 USA.
   [Kitten, Amanda K.; Ryan, Laurajo; Lee, Grace C.; Reveles, Kelly R.] Univ Texas Hlth San Antonio, Pharmacotherapy Educ & Res Ctr, San Antonio, TX 78229 USA.
   [Flores, Bertha E.] Univ Texas Hlth San Antonio, Sch Nursing, San Antonio, TX USA.
   [Flores, Bertha E.; Reveles, Kelly R.] Univ Texas Hlth San Antonio, Res Adv Community Hlth Ctr, San Antonio, TX 78229 USA.
C3 University of Texas System; University of Texas Austin; University of
   Texas System; University of Texas Health San Antonio; University of
   Texas System; University of Texas Health San Antonio; University of
   Texas System; University of Texas Health San Antonio
RP Reveles, KR (通讯作者)，Univ Texas Austin, Coll Pharm, Austin, TX 78712 USA.; Reveles, KR (通讯作者)，Univ Texas Hlth San Antonio, Pharmacotherapy Educ & Res Ctr, San Antonio, TX 78229 USA.; Reveles, KR (通讯作者)，Univ Texas Hlth San Antonio, Res Adv Community Hlth Ctr, San Antonio, TX 78229 USA.
EM kdaniels46@utexas.edu
FU Research to Advance Community Health Center, University of Texas San
   Antonio; FIRST Outpatient Research Unit, Institute for Integration of
   Medicine & Science/Clinical & Translational Science Award, UT Health San
   Antonio [UL1 TR002645]
FX This study was funded by the Research to Advance Community Health
   Center, University of Texas San Antonio (reach.uthscsa.edu) awarded to
   KRR. The funders had no role in study design, data collection and
   analysis, decision to publish, or preparation of the manuscript.
   Research support was provided by the FIRST Outpatient Research Unit,
   Institute for Integration of Medicine & Science/Clinical & Translational
   Science Award, UT Health San Antonio (UL1 TR002645).
CR Aguayo-Mazzucato C, 2019, DIABETES-METAB RES, V35, DOI 10.1002/dmrr.3097
   Ahn J, 2013, JNCI-J NATL CANCER I, V105, P1907, DOI 10.1093/jnci/djt300
   Allin KH, 2015, EUR J ENDOCRINOL, V172, pR167, DOI 10.1530/EJE-14-0874
   Amer Diabet Assoc, 2020, DIABETES CARE, V43, pS14, DOI 10.2337/dc20-S002
   Amer Diabet Assoc, 2018, DIABETES CARE, V41, pS73, DOI 10.2337/dc18-S008
   [Anonymous], 2019, HLTH EAT IND
   [Anonymous], 2019, FOOD COMPOSITION
   Armougom F, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0007125
   Brown CT, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0025792
   Cani PD, 2007, DIABETOLOGIA, V50, P2374, DOI 10.1007/s00125-007-0791-0
   Cho I, 2012, NAT REV GENET, V13, P260, DOI 10.1038/nrg3182
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Flint HJ, 2012, NAT REV GASTRO HEPAT, V9, P577, DOI 10.1038/nrgastro.2012.156
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Jie ZY, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-00900-1
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kirkpatrick SI, 2018, J ACAD NUTR DIET, V118, P1603, DOI 10.1016/j.jand.2018.05.020
   Lambeth Stacey M, 2015, J Diabetes Obes, V2, P1
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Le Chatelier E, 2013, NATURE, V500, P541, DOI 10.1038/nature12506
   Elena RIM, 2019, CURR DIABETES REV, V15, P294, DOI 10.2174/1573399814666180730124817
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Ross MC, 2015, MICROBIOME, V3, DOI 10.1186/s40168-015-0072-y
   Schwartz SS, 2016, DIABETES CARE, V39, P179, DOI 10.2337/dc15-1585
   Sedighi M, 2017, MICROB PATHOGENESIS, V111, P362, DOI 10.1016/j.micpath.2017.08.038
   Toh Michael C., 2015, Microbial Ecology in Health and Disease, V26, P26309, DOI 10.3402/mehd.v26.26309
   Wu XK, 2010, CURR MICROBIOL, V61, P69, DOI 10.1007/s00284-010-9582-9
   Zeuthen LH, 2006, CLIN VACCINE IMMUNOL, V13, P365, DOI 10.1128/CVI.13.3.365-375.2006
   Zhang XY, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0071108
   Zhu WF, 2016, CELL, V165, P111, DOI 10.1016/j.cell.2016.02.011
NR 30
TC 1
Z9 1
U1 0
U2 1
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 13
PY 2021
VL 16
IS 5
AR e0251245
DI 10.1371/journal.pone.0251245
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA SW6MO
UT WOS:000664628200054
PM 33983982
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Hung, WC
   Hung, WW
   Tsai, HJ
   Chang, CC
   Chiu, YW
   Hwang, SJ
   Kuo, MC
   Chen, SC
   Dai, CY
   Tsai, YC
AF Hung, Wei-Chun
   Hung, Wei-Wen
   Tsai, Hui-Ju
   Chang, Chen-Chia
   Chiu, Yi-Wen
   Hwang, Shang-Jyh
   Kuo, Mei-Chuan
   Chen, Szu-Chia
   Dai, Chia-Yen
   Tsai, Yi-Chun
TI The Association of Targeted Gut Microbiota with Body Composition in Type
   2 Diabetes Mellitus
SO INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
LA English
DT Article
DE Type 2 diabetes mellitus; gut microbiota; lean tissue index; Firmicutes;
   Bacteroidetes
ID MUSCLE MASS; METFORMIN; OBESITY; MALNUTRITION; METAGENOME; STRENGTH;
   FLUID
AB The association between body composition and gut microbiota in type 2 diabetes mellitus (DM) remains unknown. To elucidate the correlation of body composition and gut microbiota, we conducted a clinical study to enroll 179 patients with type 2 DM. Body composition of lean tissue index (LTI) and fat tissue index was measured by Body Composition Monitor. Eight pairs of 16S rRNA gene primers specific to Firmicutes, Bacteroidetes, the Clostridium leptum group, Bacteroides, Bifidobacterium, Akkermansia muciniphila, Escherichia coli, and Faecalibacterium prausnitzii were used to measure their abundance by quantitative polymerase chain reaction. The results showed that type 2 DM with higher abundance of phylum Firmicutes and a higher ratio of phyla Firmicutes to Bacteroidetes (phyla F/B ratio) had higher LTI. This significant correlation between phyla F/B ratio and LTI was especially evident in type 2 DM with high body mass index, and independent of glycemic control or dipeptidyl peptidase-4 inhibitor usage. In conclusion, our study demonstrated the positive association of LTI with the abundance of phylum Firmicutes and the phyla F/B ratio in type 2 DM.
C1 [Hung, Wei-Chun; Chang, Chen-Chia] Kaohsiung Med Univ, Coll Med, Dept Microbiol & Immunol, Kaohsiung, Taiwan.
   [Hung, Wei-Wen] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Endocrinol & Metab, Kaohsiung, Taiwan.
   [Tsai, Hui-Ju] Kaohsiung Med Univ, Kaohsiung Municipal Ta Tung Hosp, Dept Family Med, Kaohsiung, Taiwan.
   [Chiu, Yi-Wen; Hwang, Shang-Jyh; Kuo, Mei-Chuan; Chen, Szu-Chia; Tsai, Yi-Chun] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Nephrol, Kaohsiung, Taiwan.
   [Chiu, Yi-Wen; Hwang, Shang-Jyh; Kuo, Mei-Chuan; Chen, Szu-Chia; Tsai, Yi-Chun] Kaohsiung Med Univ, Coll Med, Fac Renal Care, Kaohsiung, Taiwan.
   [Chen, Szu-Chia; Dai, Chia-Yen; Tsai, Yi-Chun] Kaohsiung Med Univ, Coll Med, Sch Med, Kaohsiung, Taiwan.
   [Chen, Szu-Chia] Kaohsiung Med Univ, Kaohsiung Municipal Hsiao Kang Hosp, Dept Internal Med, Kaohsiung, Taiwan.
   [Dai, Chia-Yen] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Hepatobiliary, Kaohsiung, Taiwan.
   [Tsai, Yi-Chun] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Gen Med, Kaohsiung, Taiwan.
   [Tsai, Yi-Chun] Kaohsiung Med Univ, Cohort Res Ctr, Kaohsiung, Taiwan.
C3 Kaohsiung Medical University; Kaohsiung Medical University; Kaohsiung
   Medical University Hospital; Kaohsiung Medical University; Kaohsiung
   Municipal Ta-Tung Hospital; Kaohsiung Medical University; Kaohsiung
   Medical University Hospital; Kaohsiung Medical University; Kaohsiung
   Medical University; Kaohsiung Medical University; Kaohsiung Municipal
   Siao-Gang Hospital; Kaohsiung Medical University; Kaohsiung Medical
   University Hospital; Kaohsiung Medical University; Kaohsiung Medical
   University Hospital; Kaohsiung Medical University
RP Tsai, YC (通讯作者)，Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Gen Med, Kaohsiung, Taiwan.
EM lidam65@yahoo.com.tw
RI Chiu, Yi-Wen/D-5041-2009
FU Ministry of Science and Technology [MOST 108-2635-B-037004]; Kaohsiung
   Medical University [KMU-TC108B07, KMU-DK108004, SA10802]; Kaohsiung
   Medical University Hospital [KMUH106-6M11, KMUH1077M10, KMUH108-8R20,
   KMUH108-8R29]; Kaohsiung Municipal Siaogang Hospital [KMHK-A107-002]
FX This study was funded by grants from Ministry of Science and Technology
   (MOST 108-2635-B-037004), Kaohsiung Medical University (KMU-TC108B07,
   KMU-DK108004, and SA10802), Kaohsiung Medical University Hospital
   (KMUH106-6M11, KMUH1077M10, KMUH108-8R20, and KMUH108-8R29), and
   Kaohsiung Municipal Siaogang Hospital (KMHK-A107-002). The funders had
   no role in study design, data collection and analysis, decision to
   publish, or preparation of the manuscript.
CR Abbatecola AM, 2012, DRUG SAFETY, V35, P63, DOI 10.1007/BF03319104
   Allin KH, 2015, EUR J ENDOCRINOL, V172, pR167, DOI 10.1530/EJE-14-0874
   Atlantis E, 2009, METABOLISM, V58, P1013, DOI 10.1016/j.metabol.2009.02.027
   Backhed F, 2004, P NATL ACAD SCI USA, V101, P15718, DOI 10.1073/pnas.0407076101
   Brunkwall L, 2017, DIABETOLOGIA, V60, P943, DOI 10.1007/s00125-017-4278-3
   Chamney PW, 2007, AM J CLIN NUTR, V85, P80, DOI 10.1093/ajcn/85.1.80
   Cho NH, 2018, DIABETES RES CLIN PR, V138, P271, DOI 10.1016/j.diabres.2018.02.023
   Cox MA, 2009, WORLD J GASTROENTERO, V15, P5549, DOI 10.3748/wjg.15.5549
   Depommier C, 2019, NAT MED, V25, P1096, DOI 10.1038/s41591-019-0495-2
   Dugas LR, 2016, EMERG THEMES EPIDEMI, V13, DOI 10.1186/s12982-015-0044-5
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Gao ZG, 2009, DIABETES, V58, P1509, DOI 10.2337/db08-1637
   Genuth S, 2003, DIABETES CARE, V26, P3160
   Grosicki GJ, 2018, CALCIFIED TISSUE INT, V102, P433, DOI 10.1007/s00223-017-0345-5
   Heshka S, 2008, INT J OBESITY, V32, P780, DOI 10.1038/sj.ijo.0803802
   Hsiao Y.C., 2011, J INT MED TAIWAN, V22, P48
   Janssen I, 2002, J AM GERIATR SOC, V50, P889, DOI 10.1046/j.1532-5415.2002.50216.x
   Karlsson CLJ, 2012, OBESITY, V20, P2257, DOI 10.1038/oby.2012.110
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Koliada A, 2017, BMC MICROBIOL, V17, DOI 10.1186/s12866-017-1027-1
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Le KA, 2013, FRONT PHYSIOL, V3, DOI 10.3389/fphys.2012.00496
   Lin TY, 2018, KIDNEY INT, V93, P733, DOI 10.1016/j.kint.2017.08.025
   Lipsky LM, 2016, DIABETES RES CLIN PR, V120, P97, DOI 10.1016/j.diabres.2016.07.028
   Metter EJ, 2002, J GERONTOL A-BIOL, V57, pB359, DOI 10.1093/gerona/57.10.B359
   Navab-Moghadam F, 2017, MICROB PATHOGENESIS, V110, P630, DOI 10.1016/j.micpath.2017.07.034
   Pascale A, 2019, CURR OPIN PHARMACOL, V49, P1, DOI 10.1016/j.coph.2019.03.011
   Peng LY, 2009, J NUTR, V139, P1619, DOI 10.3945/jn.109.104638
   Plovier H, 2017, NAT MED, V23, P107, DOI 10.1038/nm.4236
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Rajilic-Stojanovic M, 2014, FEMS MICROBIOL REV, V38, P996, DOI 10.1111/1574-6976.12075
   Riviere A, 2016, FRONT MICROBIOL, V7, DOI 10.3389/fmicb.2016.00979
   Rosenberger J, 2014, J RENAL NUTR, V24, P172, DOI 10.1053/j.jrn.2014.01.002
   Silva WS, 2019, J DIABETES RES, V2019, DOI 10.1155/2019/5238013
   Sola D, 2015, ARCH MED SCI, V11, P840, DOI 10.5114/aoms.2015.53304
   Solanki JD, 2015, INT J PREVENTIVE MED, V6, DOI 10.4103/2008-7802.172376
   Solanki Jayesh Dalpatbhai, 2016, Niger Med J, V57, P5, DOI 10.4103/0300-1652.180562
   Thingholm LB, 2019, CELL HOST MICROBE, V26, P252, DOI 10.1016/j.chom.2019.07.004
   Tsai YC, 2014, AM J KIDNEY DIS, V63, P68, DOI 10.1053/j.ajkd.2013.06.011
   Vallianou NG, 2019, HORM-INT J ENDOCRINO, V18, P141, DOI 10.1007/s42000-019-00093-w
   Wabel P, 2009, BLOOD PURIFICAT, V27, P75, DOI 10.1159/000167013
   Wang YW, 2017, NUTRIENTS, V9, DOI 10.3390/nu9050434
   Wierzbicka E, 2018, J DIABETES RES, V2018, DOI 10.1155/2018/8121634
   Wieskotten S, 2008, PHYSIOL MEAS, V29, P639, DOI 10.1088/0967-3334/29/5/009
   Woo J, 2007, OBESITY, V15, P1886, DOI 10.1038/oby.2007.223
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Xourgia E, 2019, FRONT BIOSCI-LANDMRK, V24, P688, DOI 10.2741/4743
   Yach D, 2006, NAT MED, V12, P62, DOI 10.1038/nm0106-62
   Zhang W, 2019, BIOMED PHARMACOTHER, V118, DOI 10.1016/j.biopha.2019.109131
   Zhao LP, 2013, NAT REV MICROBIOL, V11, P639, DOI 10.1038/nrmicro3089
   Zmora N, 2019, NAT REV GASTRO HEPAT, V16, P35, DOI 10.1038/s41575-018-0061-2
NR 51
TC 12
Z9 12
U1 4
U2 16
PU IVYSPRING INT PUBL
PI LAKE HAVEN
PA PO BOX 4546, LAKE HAVEN, NSW 2263, AUSTRALIA
SN 1449-1907
J9 INT J MED SCI
JI Int. J. Med. Sci.
PY 2021
VL 18
IS 2
BP 511
EP 519
DI 10.7150/ijms.51164
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA PH7MZ
UT WOS:000600593200023
PM 33390820
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Cortellini, A
   Tucci, M
   Adamo, V
   Stucci, LS
   Russo, A
   Tanda, ET
   Spagnolo, F
   Rastelli, F
   Bisonni, R
   Santini, D
   Russano, M
   Anesi, C
   Giusti, R
   Filetti, M
   Marchetti, P
   Botticelli, A
   Gelibter, A
   Occhipinti, MA
   Marconcini, R
   Vitale, MG
   Nicolardi, L
   Chiari, R
   Bareggi, C
   Nigro, O
   Tuzi, A
   De Tursi, M
   Petragnani, N
   Pala, L
   Bracarda, S
   Macrini, S
   Inno, A
   Zoratto, F
   Veltri, E
   Di Cocco, B
   Mallardo, D
   Vitale, MG
   Pinato, DJ
   Porzio, G
   Ficorella, C
   Ascierto, PA
AF Cortellini, Alessio
   Tucci, Marco
   Adamo, Vincenzo
   Stucci, Luigia Stefania
   Russo, Alessandro
   Tanda, Enrica Teresa
   Spagnolo, Francesco
   Rastelli, Francesca
   Bisonni, Renato
   Santini, Daniele
   Russano, Marco
   Anesi, Cecilia
   Giusti, Raffaele
   Filetti, Marco
   Marchetti, Paolo
   Botticelli, Andrea
   Gelibter, Alain
   Occhipinti, Mario Alberto
   Marconcini, Riccardo
   Vitale, Maria Giuseppa
   Nicolardi, Linda
   Chiari, Rita
   Bareggi, Claudia
   Nigro, Olga
   Tuzi, Alessandro
   De Tursi, Michele
   Petragnani, Nicola
   Pala, Laura
   Bracarda, Sergio
   Macrini, Serena
   Inno, Alessandro
   Zoratto, Federica
   Veltri, Enzo
   Di Cocco, Barbara
   Mallardo, Domenico
   Vitale, Maria Grazia
   Pinato, David James
   Porzio, Giampiero
   Ficorella, Corrado
   Ascierto, Paolo Antonio
TI Integrated analysis of concomitant medications and oncological outcomes
   from PD-1/PD-L1 checkpoint inhibitors in clinical practice
SO JOURNAL FOR IMMUNOTHERAPY OF CANCER
LA English
DT Article
DE immunotherapy
ID PROTON PUMP INHIBITORS; ELDERLY-PATIENTS; GUT MICROBIOME; CANCER;
   CHOLESTEROL; ASPIRIN; ANTIBIOTICS; ASSOCIATION; METASTASIS; MELANOMA
AB Background Concomitant medications, such as steroids, proton pump inhibitors (PPI) and antibiotics, might affect clinical outcomes with immune checkpoint inhibitors. Methods We conducted a multicenter observational retrospective study aimed at evaluating the impact of concomitant medications on clinical outcomes, by weighing their associations with baseline clinical characteristics (including performance status, burden of disease and body mass index) and the underlying causes for their prescription. This analysis included consecutive stage IV patients with cancer, who underwent treatment with single agent antiprogrammed death-1/programmed death ligand-1 (PD-1/PD-L1) with standard doses and schedules at the medical oncology departments of 20 Italian institutions. Each medication taken at the immunotherapy initiation was screened and collected into key categories as follows: corticosteroids, antibiotics, gastric acid suppressants (including proton pump inhibitors - PPIs), statins and other lipid-lowering agents, aspirin, anticoagulants, non-steroidal anti-inflammatory drugs (NSAIDs), ACE inhibitors/Angiotensin II receptor blockers, calcium antagonists, beta-blockers, metformin and other oral antidiabetics, opioids. Results From June 2014 to March 2020, 1012 patients were included in the analysis. Primary tumors were: non-small cell lung cancer (52.2%), melanoma (26%), renal cell carcinoma (18.3%) and others (3.6%). Baseline statins (HR 1.60 (95% CI 1.14 to 2.25), p=0.0064), aspirin (HR 1.47 (95% CI 1.04 to 2.08, p=0.0267) and beta-blockers (HR 1.76 (95% CI 1.16 to 2.69), p=0.0080) were confirmed to be independently related to an increased objective response rate. Patients receiving cancer-related steroids (HR 1.72 (95% CI 1.43 to 2.07), p<0.0001), prophylactic systemic antibiotics (HR 1.85 (95% CI 1.23 to 2.78), p=0.0030), prophylactic gastric acid suppressants (HR 1.29 (95% CI 1.09 to 1.53), p=0.0021), PPIs (HR 1.26 (95% CI 1.07 to 1.48), p=0.0050), anticoagulants (HR 1.43 (95% CI: 1.16 to 1.77), p=0.0007) and opioids (HR 1.71 (95% CI 1.28 to 2.28), p=0.0002) were confirmed to have a significantly higher risk of disease progression. Patients receiving cancer-related steroids (HR 2.16 (95% CI 1.76 to 2.65), p<0.0001), prophylactic systemic antibiotics (HR 1.93 (95% CI 1.25 to 2.98), p=0.0030), prophylactic gastric acid suppressants (HR 1.29 (95% CI 1.06 to 1.57), p=0.0091), PPI (HR 1.26 (95% CI 1.04 to 1.52), p=0.0172), anticoagulants (HR 1.45 (95% CI 1.14 to 1.84), p=0.0024) and opioids (HR 1.53 (95% CI 1.11 to 2.11), p=0.0098) were confirmed to have a significantly higher risk of death. Conclusion We confirmed the association between baseline steroids administered for cancer-related indication, systemic antibiotics, PPIs and worse clinical outcomes with PD-1/PD-L1 checkpoint inhibitors, which can be assumed to have immune-modulating detrimental effects.
C1 [Cortellini, Alessio; Ficorella, Corrado] Univ Aquila, Dept Biotechnol & Appl Clin Sci, Laquila, Italy.
   [Cortellini, Alessio; Porzio, Giampiero; Ficorella, Corrado] Salvatore Hosp, Med Oncol, Laquila, Italy.
   [Tucci, Marco; Stucci, Luigia Stefania] Univ Bari, Dept Biomed Sci & Human Oncol, Med Oncol Unit, Bary, Italy.
   [Tucci, Marco] Tumori Inst IRCCS Giovanni Paolo II, Natl Canc Res Ctr, Bari, Italy.
   [Adamo, Vincenzo; Russo, Alessandro] Univ Messina, Dept Human Pathol, Med Oncol, AO Papardo, Messina, Italy.
   [Tanda, Enrica Teresa; Spagnolo, Francesco] IRCCS Osped Policlin San Martino, Genoa, Italy.
   [Rastelli, Francesca; Bisonni, Renato] ASUR Dist Area 4 Fermo, Med Oncol, Fermo, Italy.
   [Santini, Daniele; Russano, Marco; Anesi, Cecilia] Campus Biomed Univ, Med Oncol, Rome, Italy.
   [Giusti, Raffaele; Filetti, Marco; Marchetti, Paolo] St Andrea Hosp Rome, Med Oncol Unit, Rome, Italy.
   [Marchetti, Paolo; Botticelli, Andrea] Sapienza Univ Rome, Dept Clin & Mol Med, Rome, Italy.
   [Marchetti, Paolo; Gelibter, Alain; Occhipinti, Mario Alberto] Sapienza Univ Rome, Med Oncol Unit B, Policlin Umberto 1, Rome, Italy.
   [Marconcini, Riccardo] Azienda Osped Univ Pisana, Med Oncol, Pisa, Italy.
   [Vitale, Maria Giuseppa] Univ Hosp Modena, Med Oncol, Modena, Italy.
   [Nicolardi, Linda; Chiari, Rita] Azienda ULSS 6 Euganea, UOC Oncol Padova Sud, Padua, Italy.
   [Bareggi, Claudia] Fdn IRCCS Ca Granda Osped Maggiore Milano Policli, Med Oncol Unit, Milan, Italy.
   [Nigro, Olga; Tuzi, Alessandro] Osped Circolo & Fdn Macchi, Med Oncol, ASST Sette Laghi, Varese, Italy.
   [De Tursi, Michele] Gabriele dAnnunzio Univ Chieti & Pescara, Dept Med Oral & Biotechnol Sci, Chieti, Italy.
   [Petragnani, Nicola] Univ G DAnnunzio Chieti & Pescara, Dept Psychol Hlth & Terr Sci, Chieti, Italy.
   [Pala, Laura] IEO European Inst Oncol IRCCS, Div Med Oncol Melanoma, Sarcoma & Rare Tumors, Milan, Italy.
   [Bracarda, Sergio; Macrini, Serena] Azienda Osped S Maria, Med Oncol, Terni, Italy.
   [Inno, Alessandro] IRCCS Osped Sacro Cuore Don Calabria, Oncol Unit, Negrar, Italy.
   [Zoratto, Federica; Veltri, Enzo; Di Cocco, Barbara] Santa Maria Goretti Hosp, Med Oncol, Latina, Italy.
   [Mallardo, Domenico; Vitale, Maria Grazia; Ascierto, Paolo Antonio] Ist Nazl Tumori IRCCS Fdn G Pascale, Melanoma Canc Immunotherapy & Dev Therapeut Unit, Naples, Italy.
   [Pinato, David James] Imperial Coll London, Hammersmith Hosp, Dept Surg & Canc, Div Canc, London, England.
C3 University of L'Aquila; Universita degli Studi di Bari Aldo Moro; IRCCS
   Istituto Tumori Bari Giovanni Paolo II; University of Messina;
   University Campus Bio-Medico - Rome Italy; Sapienza University Rome;
   Azienda Ospedaliera Sant'Andrea; Sapienza University Rome; Sapienza
   University Rome; University Hospital Sapienza Rome; University of Pisa;
   Azienda Ospedaliero Universitaria Pisana; Universita di Modena e Reggio
   Emilia; Universita di Modena e Reggio Emilia Hospital; Ospedale Circolo
   & Fondazione Macchi; G d'Annunzio University of Chieti-Pescara; G
   d'Annunzio University of Chieti-Pescara; IRCCS Sacro Cuore Don Calabria;
   IRCCS Fondazione Pascale; Imperial College London
RP Cortellini, A (通讯作者)，Univ Aquila, Dept Biotechnol & Appl Clin Sci, Laquila, Italy.; Cortellini, A (通讯作者)，Salvatore Hosp, Med Oncol, Laquila, Italy.
EM alessiocortellini@gmail.com
RI Pala, Laura/AHD-9154-2022; Filetti, Marco/ABE-8668-2021; Vitale,
   Maria/HJZ-2156-2023; Inno, Alessandro/AAA-8268-2022; stucci, luigia
   stefania/I-7465-2018; Inno, Alessandro/ISB-4184-2023; DE TURSI,
   MICHELE/L-3427-2016; Giusti, Raffaele/AAC-9723-2020; Petragnani,
   Nicola/HGE-9328-2022; Botticelli, Andrea/J-9926-2018; Mallardo,
   Domenico/I-8649-2018; Russo, Alessandro/P-9929-2019
OI Vitale, Maria/0000-0002-4399-3132; Inno, Alessandro/0000-0001-6331-6908;
   Inno, Alessandro/0000-0001-6331-6908; DE TURSI,
   MICHELE/0000-0002-1411-1946; Giusti, Raffaele/0000-0003-4592-8868;
   Petragnani, Nicola/0000-0001-6460-3028; Botticelli,
   Andrea/0000-0002-6425-9893; Mallardo, Domenico/0000-0002-1081-5313;
   Russo, Alessandro/0000-0002-3365-1972; chiari, rita/0000-0002-7649-273X;
   gelibter, alain/0000-0002-7832-5281; Bracarda,
   Sergio/0000-0002-0703-2959; Pinato, David James/0000-0002-3529-0103;
   Vitale, Maria Giuseppa/0000-0001-8551-266X; Cortellini,
   Alessio/0000-0002-1209-5735
FU Consorzio Interuniversitario Nazionale per la Bio-Oncologia (CINBO);
   Wellcome Trust Strategic Fund [PS3416]; NIHR Imperial Biomedical
   Research Center (BRC) ITMAT Push for Impact Scheme 2019
FX This work was supported by the Consorzio Interuniversitario Nazionale
   per la Bio-Oncologia (CINBO). DP is supported by grant funding from the
   Wellcome Trust Strategic Fund (PS3416) and from the NIHR Imperial
   Biomedical Research Center (BRC) ITMAT Push for Impact Scheme 2019 and
   acknowledges infrastructural support by the Cancer Research UK Imperial
   Center and the Imperial Experimental Cancer Medicine Center (ECMC).
CR Acharya C, 2017, ALIMENT PHARM THER, V45, P319, DOI [10.1111/apt.13858, 10.1111/apt.14585]
   Afzal MZ, 2018, J IMMUNOTHER CANCER, V6, DOI 10.1186/s40425-018-0375-1
   Algra AM, 2012, LANCET ONCOL, V13, P518, DOI 10.1016/S1470-2045(12)70112-2
   Arbour KC, 2018, J CLIN ONCOL, V36, P2872, DOI 10.1200/JCO.2018.79.0006
   Azawi NH, 2016, ACTA ONCOL, V55, P79, DOI 10.3109/0284186X.2015.1115121
   Banerjee S, 2016, MUCOSAL IMMUNOL, V9, P1418, DOI 10.1038/mi.2016.9
   Biswas S, 2012, BMC MED, V10, DOI 10.1186/1741-7015-10-57
   Botti G, 2017, J TRANSL MED, V15, DOI 10.1186/s12967-017-1150-7
   Bruno G, 2019, WORLD J GASTROENTERO, V25, P2706, DOI 10.3748/wjg.v25.i22.2706
   Chalabi M, 2020, ANN ONCOL, V31, P525, DOI [10.1016/j.annonc.2020.01.006, 10.1016/j.annoc.2020.01.006]
   Ciocan D, 2013, JAMA DERMATOL, V149, P1150, DOI 10.1001/jamadermatol.2013.706
   Cortellini A, 2020, EUR J CANCER, V128, P17, DOI 10.1016/j.ejca.2019.12.031
   Cortellini A, 2020, ONCOIMMUNOLOGY, V9, DOI 10.1080/2162402X.2019.1710389
   Cortellini A, 2019, J TRANSL MED, V17, DOI 10.1186/s12967-019-02132-x
   Cortellini A, 2019, CLIN LUNG CANCER, V20, P237, DOI 10.1016/j.cllc.2019.02.006
   Cortellini A, 2019, J IMMUNOTHER CANCER, V7, DOI 10.1186/s40425-019-0527-y
   Cortellini A, 2019, ONCOLOGIST, V24, pE327, DOI 10.1634/theoncologist.2018-0618
   Coutinho AE, 2011, MOL CELL ENDOCRINOL, V335, P2, DOI 10.1016/j.mce.2010.04.005
   Dai XY, 2017, CLIN CANCER RES, V23, P6267, DOI 10.1158/1078-0432.CCR-17-0242
   De Giorgi V, 2018, JAMA ONCOL, V4, DOI 10.1001/jamaoncol.2017.2908
   Derosa L, 2018, ANN ONCOL, V29, P1437, DOI 10.1093/annonc/mdy103
   Diebel LN, 2011, SURGERY, V150, P736, DOI 10.1016/j.surg.2011.07.067
   Eisenhauer EA, 2009, EUR J CANCER, V45, P228, DOI 10.1016/j.ejca.2008.10.026
   European Medicines Agencies, EMA REV RAN MED FOLL
   Gandhi S, 2020, IMMUNOTHERAPY-UK, V12, P141, DOI 10.2217/imt-2019-0064
   Gao CX, 2015, MBIO, V6, DOI 10.1128/mBio.01358-15
   Giles AJ, 2018, J IMMUNOTHER CANCER, V6, DOI 10.1186/s40425-018-0371-5
   Gopalakrishnan V, 2018, CANCER CELL, V33, P570, DOI 10.1016/j.ccell.2018.03.015
   Gridelli C, 2015, CLIN LUNG CANCER, V16, P325, DOI 10.1016/j.cllc.2015.02.006
   Hagan T, 2019, CELL, V178, P1313, DOI 10.1016/j.cell.2019.08.010
   Hakozaki T, 2020, J CANCER RES CLIN, V146, P2659, DOI 10.1007/s00432-020-03252-4
   He ZX, 2019, FRONT MICROBIOL, V10, DOI 10.3389/fmicb.2019.00978
   Homicsko K, 2018, ANN ONCOL, V29, P40
   Hussain M, 2012, INT IMMUNOPHARMACOL, V12, P10, DOI 10.1016/j.intimp.2011.11.021
   Hussain N, 2021, HUM VACC IMMUNOTHER, V17, P55, DOI 10.1080/21645515.2020.1769398
   Jackson MA, 2016, GUT, V65, P749, DOI 10.1136/gutjnl-2015-310861
   Kichenadasse G, 2020, JAMA ONCOL, V6, P512, DOI 10.1001/jamaoncol.2019.5241
   Kokolus KM, 2018, ONCOIMMUNOLOGY, V7, DOI 10.1080/2162402X.2017.1405205
   Li ZY, 2016, ACTA PHARMACOL SIN, V37, P1458, DOI 10.1038/aps.2016.70
   Luo Y, 2016, FRONT IMMUNOL, V7, DOI 10.3389/fimmu.2016.00604
   Ma XZ, 2019, CELL METAB, V30, P143, DOI 10.1016/j.cmet.2019.04.002
   Malmberg KJ, 2004, CANCER IMMUNOL IMMUN, V53, P879, DOI 10.1007/s00262-004-0577-x
   Minana B, 2014, J UROLOGY, V191, P323, DOI 10.1016/j.juro.2013.08.049
   Mok EHK, 2020, CANCERS, V12, DOI 10.3390/cancers12061410
   Perrone F, 2020, J IMMUNOTHER, V43, P196, DOI 10.1097/CJI.0000000000000321
   Petrelli F, 2020, CANCERS, V12, DOI 10.3390/cancers12030546
   Pinato DJ, 2019, JAMA ONCOL, V5, P1774, DOI 10.1001/jamaoncol.2019.2785
   Ren MH, 2020, BEHAV PHARMACOL, V31, P113, DOI 10.1097/FBP.0000000000000538
   Ricciuti B, 2019, J CLIN ONCOL, V37, P1927, DOI 10.1200/JCO.19.00189
   Scripture CD, 2006, NAT REV CANCER, V6, P546, DOI 10.1038/nrc1887
   Strobel L, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-28583-8
   Taylor A., 2018, J PAIN, V19, P1
   Thiele M, 2013, MED HYPOTHESES, V81, P871, DOI 10.1016/j.mehy.2013.08.026
   Thompson F., 1997, MULTIPLE LINES REGRE, V24, P11
   U.S. Food & Drug Administration, QUEST ANSW NDMA IMP
   Wang DY, 2020, ONCOLOGIST, V25, pE602, DOI 10.1634/theoncologist.2019-0518
   Woolley K. K., 1997, ANN M SW ED RES ASS
   Wu T, 2018, LIFE SCI, V192, P173, DOI 10.1016/j.lfs.2017.11.049
   Yang W, 2016, NATURE, V531, P651, DOI 10.1038/nature17412
   Zelenay S, 2015, CELL, V162, P1257, DOI 10.1016/j.cell.2015.08.015
NR 60
TC 89
Z9 92
U1 3
U2 20
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
EI 2051-1426
J9 J IMMUNOTHER CANCER
JI J. Immunother. Cancer
PY 2020
VL 8
IS 2
AR e001361
DI 10.1136/jitc-2020-001361
PG 16
WC Oncology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Immunology
GA OT3CA
UT WOS:000590726400002
PM 33154150
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Chen, WW
   Yu, YY
   Liu, Y
   Song, CJ
   Chen, HH
   Tang, C
   Song, Y
   Zhang, XL
AF Chen, Weiwei
   Yu, Yingying
   Liu, Yang
   Song, ChaoJie
   Chen, HuanHuan
   Tang, Cong
   Song, Yu
   Zhang, Xiaoli
TI Ursolic acid regulates gut microbiota and corrects the imbalance of
   Th17/Treg cells in T1DM rats
SO PLOS ONE
LA English
DT Article
ID T-CELLS; TH17 CELLS; TYPE-1; METFORMIN; RECEPTOR; MICE
AB Ursolic acid (UA), a natural pentacyclic triterpenoid obtained from fruit and several traditional Chinese medicinal plants, exhibits anti-inflammatory and hypoglycemic properties. However, its protective effects against type 1 diabetes mellitus (T1DM) have not been explored. In this study, streptozotocin-induced T1DM rat models were established and treated with UA for six weeks. T1DM rats treated with UA were used to observe the effects of UA on body weight and fasting blood glucose (FBG) levels. Pathological changes in the pancreas were observed using immunohistochemical staining. The gut microbiota distribution was measured using 16S rDNA high-throughput sequencing. The proportions of Th17 and Treg cells were examined using flow cytometry. Protein and mRNA expression of molecules involved in Th17/Treg cell differentiation were assessed by quantitative real-time PCR and western blotting. The correlation between gut microbiota and Th17/Treg cell differentiation in T1DM was analyzed using redundancy analysis (RDA) analysis. Compared with the model group, FBG levels declined, and the progressive destruction of pancreatic beta cells was alleviated. The diversity and uniformity of gut microbiota in T1DM rats treated with UA increased significantly. Interestingly, the Th17/Treg cell differentiation imbalance was corrected and positively correlated with the expression of Foxp3 and IL-10, and negatively correlated with the expression of ROR gamma t, IL-17A, and TNF-alpha. These findings suggest that UA can lower FBG levels in T1DM rats, delay the progressive destruction of pancreatic beta-cells, and modulate gut microbiota homeostasis and immune function in streptozotocin-induced T1DM rats.
C1 [Chen, Weiwei; Liu, Yang] Henan Univ Chinese Med, Tradit Chinese Med Zhong Jing Sch, Zhengzhou, Henan, Peoples R China.
   [Yu, Yingying] Luohe Med Coll, Affiliated Hosp 2, Luohe, Henan, Peoples R China.
   [Yu, Yingying; Song, ChaoJie; Chen, HuanHuan; Tang, Cong; Song, Yu; Zhang, Xiaoli] Henan Univ Chinese Med, Sch Med, Zhengzhou, Henan, Peoples R China.
C3 Henan University of Traditional Chinese Medicine; Henan University of
   Traditional Chinese Medicine
RP Zhang, XL (通讯作者)，Henan Univ Chinese Med, Sch Med, Zhengzhou, Henan, Peoples R China.
EM zxl7666@163.com
RI yu, yingying/GRR-7851-2022; Chen, Huanhuan/HTO-5007-2023
FU Henan Province Key University Project: Study on the hypoglycemic
   mechanism of ursolic acid based on the regulation of Th17/Treg cell
   balance by gut microbiota [20B310005]; Henan Province Science and
   Technology Research Project: The mechanism of ursolic acid in
   alleviating type 1 diabetes based on the regulation of RORgammat/Foxp3
   signaling pathway by gut microbiota [212102311081]; Henan Province Key
   University [172102310091]
FX This work was supported by the Henan Province Key University Project:
   Study on the hypoglycemic mechanism of ursolic acid based on the
   regulation of Th17/Treg cell balance by gut microbiota(20B310005),the
   Henan Province Science and Technology Research Project: The mechanism of
   ursolic acid in alleviating type 1 diabetes based on the regulation of
   ROR gamma t/Foxp3 signaling pathway by gut microbiota (212102311081) and
   the Henan Province Key University Project: Study on the mechanism of
   ursolic acid on IFN-gamma and IL-4 cytokine signal transduction in
   diabetes(172102310091).
CR Alkreathy HM, 2020, OXID MED CELL LONGEV, V2020, DOI 10.1155/2020/8565760
   [Anonymous], 2005, DIABETES CARE, V28, pS4
   Atarashi K, 2011, SCIENCE, V331, P337, DOI 10.1126/science.1198469
   Baek SY, 2014, ACTA PHARMACOL SIN, V35, P1177, DOI 10.1038/aps.2014.58
   Bjornstad P, 2018, CIRCULATION, V138, P2895, DOI 10.1161/CIRCULATIONAHA.118.035525
   Chen H, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.01662
   Chen K, 2017, MOL NUTR FOOD RES, V61, DOI 10.1002/mnfr.201601006
   Demirci M, 2020, J DIABETES COMPLICAT, V34, DOI 10.1016/j.jdiacomp.2019.107449
   DiMeglio LA, 2018, LANCET, V391, P2449, DOI 10.1016/S0140-6736(18)31320-5
   Ding H, 2017, NEUROCHEM RES, V42, P337, DOI 10.1007/s11064-016-2077-8
   Duan W, 2019, AM J TRANSL RES, V11, P2393
   Dujic T, 2015, DIABETES, V64, P1786, DOI 10.2337/db14-1388
   Emamaullee JA, 2009, DIABETES, V58, P1302, DOI 10.2337/db08-1113
   Mejia-Leon ME, 2014, SCI REP-UK, V4, DOI 10.1038/srep03814
   Fabbri M, 2019, DIABETES, V68, P258, DOI 10.2337/db18-0627
   Fassatoui M, 2019, BIOSCIENCE REP, V39, DOI 10.1042/BSR20182348
   Ferraro A, 2011, DIABETES, V60, P2903, DOI 10.2337/db11-0090
   Gudi R, 2019, IMMUNOLOGY, V157, P70, DOI 10.1111/imm.13048
   Gudoityte E, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22094599
   Guzman-Avila R, 2018, DRUG DEVELOP RES, V79, P70, DOI 10.1002/ddr.21422
   Harbison JE, 2019, PEDIATR DIABETES, V20, P574, DOI 10.1111/pedi.12865
   Homann D, 2004, CLIN IMMUNOL, V112, P202, DOI 10.1016/j.clim.2004.03.020
   Hu CY, 2015, PHARMACOL RES, V98, P9, DOI 10.1016/j.phrs.2015.02.006
   Huang Y, 2018, DIABETES RES CLIN PR, V141, P256, DOI 10.1016/j.diabres.2018.04.032
   Hunter RW, 2018, NAT MED, V24, P1395, DOI 10.1038/s41591-018-0159-7
   Nguyen HN, 2018, ATHEROSCLEROSIS, V275, P333, DOI 10.1016/j.atherosclerosis.2018.06.882
   Ichiyama K, 2008, J BIOL CHEM, V283, P17003, DOI 10.1074/jbc.M801286200
   Jang SE, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-25775-0
   Jang SM, 2009, INT IMMUNOPHARMACOL, V9, P113, DOI 10.1016/j.intimp.2008.10.013
   Kang DY, 2021, BIOMEDICINES, V9, DOI 10.3390/biomedicines9030297
   Kim TK, 2020, FRONT IMMUNOL, V11, DOI 10.3389/fimmu.2020.01832
   Kristensen JM, 2014, AM J PHYSIOL-ENDOC M, V306, pE1099, DOI 10.1152/ajpendo.00417.2013
   Kuriya G, 2013, DIABETOLOGIA, V56, P1773, DOI 10.1007/s00125-013-2935-8
   Lee GR, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19030730
   Liang X, 2020, J IMMUNOL RES, V2020, DOI 10.1155/2020/6841078
   Liu X, 2021, WORLD J GASTROENTERO, V27, P2394, DOI 10.3748/wjg.v27.i19.2394
   Lo SH, 2017, N-S ARCH PHARMACOL, V390, P1097, DOI 10.1007/s00210-017-1409-9
   Luchnikova NA, 2020, MOLECULES, V25, DOI 10.3390/molecules25235526
   Mayer-Davis EJ, 2017, NEW ENGL J MED, V376, P1419, DOI 10.1056/NEJMoa1610187
   McCreight LJ, 2016, DIABETOLOGIA, V59, P426, DOI 10.1007/s00125-015-3844-9
   Mlala S, 2019, MOLECULES, V24, DOI 10.3390/molecules24152751
   Murri M, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-46
   Omenetti S, 2015, FRONT IMMUNOL, V6, DOI 10.3389/fimmu.2015.00639
   Papaccio G, 2002, J CELL BIOCHEM, V86, P651, DOI 10.1002/jcb.10250
   Patterson CC, 2019, DIABETES RES CLIN PR, V157, DOI 10.1016/j.diabres.2019.107842
   Peng F, 2021, FRONT PHYSIOL, V12, DOI 10.3389/fphys.2021.650190
   Peshattiwar V, 2020, BRAIN RES BULL, V160, P150, DOI 10.1016/j.brainresbull.2020.03.003
   Rewers M, 2016, LANCET, V387, P2340, DOI 10.1016/S0140-6736(16)30507-4
   Ryba-Stanislawowska M, 2013, HUM IMMUNOL, V74, P701, DOI 10.1016/j.humimm.2013.01.024
   Salomon B, 2000, IMMUNITY, V12, P431, DOI 10.1016/S1074-7613(00)80195-8
   Seven A, 2004, YONSEI MED J, V45, P703, DOI 10.3349/ymj.2004.45.4.703
   Stewart CJ, 2018, NATURE, V562, P583, DOI 10.1038/s41586-018-0617-x
   Sun Q, 2020, FITOTERAPIA, V147, DOI 10.1016/j.fitote.2020.104735
   Tang SG, 2022, J OLEO SCI, V71, P289, DOI 10.5650/jos.ess21258
   Theurey P, 2022, PHYSIOL REP, V10, DOI 10.14814/phy2.15151
   Vignali DAA, 2008, NAT REV IMMUNOL, V8, P523, DOI 10.1038/nri2343
   Vojislav C, 2020, BMC ENDOCR DISORD, V20, DOI 10.1186/s12902-020-0504-y
   Wang J, 2020, J SCI FOOD AGR, V100, P986, DOI 10.1002/jsfa.10098
   Xu H, 2015, J NEUROIMMUNOL, V281, P61, DOI 10.1016/j.jneuroim.2015.02.010
   Xue ML, 2019, BIOMED PHARMACOTHER, V118, DOI 10.1016/j.biopha.2019.109393
   Zhang W, 2006, BBA-GEN SUBJECTS, V1760, P1505, DOI 10.1016/j.bbagen.2006.05.009
   Zhao HL, 2021, DRUG DES DEV THER, V15, P2339, DOI 10.2147/DDDT.S288011
   Zheng PL, 2018, DIABETES-METAB RES, V34, DOI 10.1002/dmrr.3043
   Zhou H, 2020, DIS MARKERS, V2020, DOI 10.1155/2020/3936247
NR 64
TC 0
Z9 0
U1 12
U2 14
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD NOV 3
PY 2022
VL 17
IS 11
AR e0277061
DI 10.1371/journal.pone.0277061
PG 17
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 8N3RJ
UT WOS:000925067300090
PM 36327331
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Maier, L
   Pruteanu, M
   Kuhn, M
   Zeller, G
   Telzerow, A
   Anderson, EE
   Brochado, AR
   Fernandez, KC
   Dose, H
   Mori, H
   Patil, KR
   Bork, P
   Typas, A
AF Maier, Lisa
   Pruteanu, Mihaela
   Kuhn, Michael
   Zeller, Georg
   Telzerow, Anja
   Anderson, Exene Erin
   Brochado, Ana Rita
   Fernandez, Keith Conrad
   Dose, Hitomi
   Mori, Hirotada
   Patil, Kiran Raosaheb
   Bork, Peer
   Typas, Athanasios
TI Extensive impact of non-antibiotic drugs on human gut bacteria
SO NATURE
LA English
DT Article
ID ESCHERICHIA-COLI; MICROBIOME; SUSCEPTIBILITY; IDENTIFICATION;
   INHIBITORS; METFORMIN; PROTEIN; ANNOTATION; RESISTANCE; INTESTINE
AB A few commonly used non-antibiotic drugs have recently been associated with changes in gut microbiome composition, but the extent of this phenomenon is unknown. Here, we screened more than 1,000 marketed drugs against 40 representative gut bacterial strains, and found that 24% of the drugs with human targets, including members of all therapeutic classes, inhibited the growth of at least one strain in vitro. Particular classes, such as the chemically diverse antipsychotics, were overrepresented in this group. The effects of human-targeted drugs on gut bacteria are reflected on their antibiotic-like side effects in humans and are concordant with existing human cohort studies. Susceptibility to antibiotics and human-targeted drugs correlates across bacterial species, suggesting common resistance mechanisms, which we verified for some drugs. The potential risk of non-antibiotics promoting antibiotic resistance warrants further exploration. Our results provide a resource for future research on drug-microbiome interactions, opening new paths for side effect control and drug repurposing, and broadening our view of antibiotic resistance.
C1 [Maier, Lisa; Pruteanu, Mihaela; Telzerow, Anja; Anderson, Exene Erin; Brochado, Ana Rita; Fernandez, Keith Conrad; Typas, Athanasios] European Mol Biol Lab, Genome Biol Unit, D-69117 Heidelberg, Germany.
   [Kuhn, Michael; Zeller, Georg; Patil, Kiran Raosaheb; Bork, Peer; Typas, Athanasios] European Mol Biol Lab, Struct & Computat Biol Unit, D-69117 Heidelberg, Germany.
   [Dose, Hitomi; Mori, Hirotada] Nara Inst Sci & Technol, Grad Sch Biol Sci, Ikoma 6300101, Japan.
   [Bork, Peer] Max Delbruck Ctr Mol Med, D-13125 Berlin, Germany.
   [Bork, Peer] Mol Med Partnership Unit, D-69120 Heidelberg, Germany.
   [Bork, Peer] Univ Wurzburg, Dept Bioinformat, Bioctr, D-97024 Wurzburg, Germany.
   [Pruteanu, Mihaela] Humboldt Univ, Inst Biol, D-10115 Berlin, Germany.
C3 European Molecular Biology Laboratory (EMBL); European Molecular Biology
   Laboratory (EMBL); Nara Institute of Science & Technology; Helmholtz
   Association; Max Delbruck Center for Molecular Medicine; University of
   Wurzburg; Humboldt University of Berlin
RP Typas, A (通讯作者)，European Mol Biol Lab, Genome Biol Unit, D-69117 Heidelberg, Germany.; Zeller, G; Patil, KR; Bork, P; Typas, A (通讯作者)，European Mol Biol Lab, Struct & Computat Biol Unit, D-69117 Heidelberg, Germany.; Bork, P (通讯作者)，Max Delbruck Ctr Mol Med, D-13125 Berlin, Germany.; Bork, P (通讯作者)，Mol Med Partnership Unit, D-69120 Heidelberg, Germany.; Bork, P (通讯作者)，Univ Wurzburg, Dept Bioinformat, Bioctr, D-97024 Wurzburg, Germany.
EM zeller@embl.de; patil@embl.de; bork@embl.de; typas@embl.de
RI Patil, Kiran R/B-9709-2009; Kuhn, Michael/D-4978-2009; Bork,
   Peer/F-1813-2013; Maier, Lisa/ABH-1893-2021; Zeller, Georg/M-6484-2013
OI Patil, Kiran R/0000-0002-6166-8640; Kuhn, Michael/0000-0002-2841-872X;
   Bork, Peer/0000-0002-2627-833X; Maier, Lisa/0000-0002-6473-4762;
   Brochado, Ana Rita/0000-0003-1703-383X; Zeller,
   Georg/0000-0003-1429-7485; Typas, Athanasios/0000-0002-0797-9018;
   Telzerow, Anja/0000-0001-9855-0809; Pruteanu,
   Mihaela/0000-0003-0484-8503; Fernandez, Keith Conrad/0000-0003-3757-8271
FU European Research Council [669830] Funding Source: Medline
CR ARIZA RR, 1995, J BACTERIOL, V177, P1655, DOI 10.1128/jb.177.7.1655-1661.1995
   Arumugam M, 2011, NATURE, V473, P174, DOI 10.1038/nature09944
   Bailey CJ, 2008, DIABETOLOGIA, V51, P1552, DOI 10.1007/s00125-008-1053-5
   BENJAMINI Y, 1995, J R STAT SOC B, V57, P289, DOI 10.1111/j.2517-6161.1995.tb02031.x
   Blaser MJ, 2016, SCIENCE, V352, P544, DOI 10.1126/science.aad9358
   BODET CA, 1985, ANTIMICROB AGENTS CH, V28, P437, DOI 10.1128/AAC.28.3.437
   Cacace Elisabetta, 2017, Curr Opin Syst Biol, V4, P35, DOI 10.1016/j.coisb.2017.05.020
   Campillos M, 2008, SCIENCE, V321, P263, DOI 10.1126/science.1158140
   Clemente JC, 2015, SCI ADV, V1, DOI 10.1126/sciadv.1500183
   Deghou S, 2016, BIOINFORMATICS, V32, P2869, DOI 10.1093/bioinformatics/btw233
   Roldan M, 2008, FEMS MICROBIOL REV, V32, P474, DOI 10.1111/j.1574-6976.2008.00107.x
   Donaldson GP, 2016, NAT REV MICROBIOL, V14, P20, DOI 10.1038/nrmicro3552
   Ejim L, 2011, NAT CHEM BIOL, V7, P348, DOI [10.1038/NCHEMBIO.559, 10.1038/nchembio.559]
   Falony G, 2016, SCIENCE, V352, P560, DOI 10.1126/science.aad3503
   Farha MA, 2015, P NATL ACAD SCI USA, V112, P11048, DOI 10.1073/pnas.1511751112
   Flowers SA, 2017, PHARMACOTHERAPY, V37, P261, DOI 10.1002/phar.1890
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Goodman AL, 2011, P NATL ACAD SCI USA, V108, P6252, DOI 10.1073/pnas.1102938108
   Gustafsson C, 1998, J BACTERIOL, V180, P359, DOI 10.1128/JB.180.2.359-365.1998
   Harbut MB, 2015, P NATL ACAD SCI USA, V112, P4453, DOI 10.1073/pnas.1504022112
   Hens B, 2016, J PHARM SCI-US, V105, P2677, DOI 10.1002/jps.24690
   Huttenhower C, 2012, NATURE, V486, P207, DOI 10.1038/nature11234
   Imhann F, 2016, GUT, V65, P740, DOI 10.1136/gutjnl-2015-310376
   Jackson MA, 2016, GUT, V65, P749, DOI 10.1136/gutjnl-2015-310861
   Kahrstrom CT, 2016, NATURE, V535, P47, DOI 10.1038/535047a
   Kim ER, 2012, J NEUROGASTROENTEROL, V18, P94, DOI 10.5056/jnm.2012.18.1.94
   Kim S, 2016, NUCLEIC ACIDS RES, V44, pD1202, DOI 10.1093/nar/gkv951
   Koh A, 2016, CELL, V165, P1332, DOI 10.1016/j.cell.2016.05.041
   Kritikos G, 2017, NAT MICROBIOL, V2, DOI 10.1038/nmicrobiol.2017.14
   Kruschke JK, 2013, J EXP PSYCHOL GEN, V142, P573, DOI 10.1037/a0029146
   Kuhn M, 2016, NUCLEIC ACIDS RES, V44, pD1075, DOI 10.1093/nar/gkv1075
   Kuhn M, 2014, NUCLEIC ACIDS RES, V42, pD401, DOI 10.1093/nar/gkt1207
   Kultima JR, 2016, BIOINFORMATICS, V32, P2520, DOI 10.1093/bioinformatics/btw183
   Law V, 2014, NUCLEIC ACIDS RES, V42, pD1091, DOI 10.1093/nar/gkt1068
   Li XZ, 2015, CLIN MICROBIOL REV, V28, P337, DOI 10.1128/CMR.00117-14
   MATTHEWS DA, 1977, SCIENCE, V197, P452, DOI 10.1126/science.17920
   Mende DR, 2013, NAT METHODS, V10, P881, DOI [10.1038/NMETH.2575, 10.1038/nmeth.2575]
   Morgan AP, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0115225
   Mori H, 2015, METHOD MOL BIOL, P45
   Morita Y, 1998, ANTIMICROB AGENTS CH, V42, P1778, DOI 10.1128/AAC.42.7.1778
   Mudie DM, 2014, MOL PHARMACEUT, V11, P3039, DOI 10.1021/mp500210c
   Nagy E, 2011, CLIN MICROBIOL INFEC, V17, P371, DOI 10.1111/j.1469-0691.2010.03256.x
   Nasie I, 2012, J BACTERIOL, V194, P6766, DOI 10.1128/JB.01318-12
   Nichols RJ, 2011, CELL, V144, P143, DOI 10.1016/j.cell.2010.11.052
   Nielsen HB, 2014, NAT BIOTECHNOL, V32, P822, DOI 10.1038/nbt.2939
   Otsuka Y, 2015, NUCLEIC ACIDS RES, V43, pD606, DOI 10.1093/nar/gku1164
   Pasolli E, 2016, PLOS COMPUT BIOL, V12, DOI 10.1371/journal.pcbi.1004977
   Pritchard SE, 2014, NEUROGASTROENT MOTIL, V26, P124, DOI 10.1111/nmo.12243
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Qin JJ, 2010, NATURE, V464, P59, DOI 10.1038/nature08821
   Rani N, 2013, MINI-REV MED CHEM, V13, P1812
   Rettedal EA, 2014, NAT COMMUN, V5, DOI 10.1038/ncomms5714
   Rogers M. A., 2016, CLIN MICROBIOL INFEC, V22, P171
   Schloissnig S, 2013, NATURE, V493, P45, DOI 10.1038/nature11711
   Sharma S, 2011, EXPERT OPIN INV DRUG, V20, P1665, DOI 10.1517/13543784.2011.628657
   Spanogiannopoulos P, 2016, NAT REV MICROBIOL, V14, P273, DOI 10.1038/nrmicro.2016.17
   Steinbeck C, 2006, CURR PHARM DESIGN, V12, P2111, DOI 10.2174/138161206777585274
   Stringer AM, 2009, CURR DRUG METAB, V10, P79, DOI 10.2174/138920009787048419
   Sulavik MC, 2001, ANTIMICROB AGENTS CH, V45, P1126, DOI 10.1128/AAC.45.4.1126-1136.2001
   TABER HW, 1987, MICROBIOL REV, V51, P439, DOI 10.1128/MMBR.51.4.439-457.1987
   Tramontano M., 2018, NAT MICROBIOL
   Turnidge J, 2007, CLIN MICROBIOL REV, V20, P391, DOI 10.1128/CMR.00047-06
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
NR 63
TC 916
Z9 945
U1 14
U2 441
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0028-0836
EI 1476-4687
J9 NATURE
JI Nature
PD MAR 29
PY 2018
VL 555
IS 7698
BP 623
EP +
DI 10.1038/nature25979
PG 24
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA GA8UX
UT WOS:000428617600042
PM 29555994
OA Green Accepted
HC Y
HP N
DA 2023-06-08
ER

PT J
AU Hariyanto, TI
   Intan, D
   Hananto, JE
   Putri, C
   Kurniawan, A
AF Hariyanto, Timotius Ivan
   Intan, Denny
   Hananto, Joshua Edward
   Putri, Cynthia
   Kurniawan, Andree
TI Pre-admission glucagon-like peptide-1 receptor agonist (GLP-1RA) and
   mortality from coronavirus disease 2019 (Covid-19): A systematic review,
   meta-analysis, and meta-regression
SO DIABETES RESEARCH AND CLINICAL PRACTICE
LA English
DT Review
DE Coronavirus disease 2019; Covid-19; Diabetes; GLP-1RA; Anti-diabetic
ID OBSTRUCTIVE SLEEP-APNEA; LUNG-FUNCTION; 3.0 MG; LIRAGLUTIDE; WEIGHT;
   SCALE; INFLAMMATION; PNEUMONIA; OUTCOMES
AB Aims: GLP-1RA has many beneficial properties, including anti-inflammatory, anti-obesogenic, pulmonary protective effects as well as beneficial impact on gut microbiome. However, the evidence regarding the benefit of GLP-1RA in Covid-19 patients with diabetes is still unclear. This study sought to analyze the benefit of pre-admission use of GLP-1RA in altering the mortality outcomes of coronavirus disease 2019 (Covid-19) patients with diabetes mellitus.
   Methods: Using specific keywords, we comprehensively searched the potential articles on PubMed, Europe PMC, and medRxiv database until June 12th, 2021. All published studies on Covid-19 and GLP-1RA were retrieved. Statistical analysis was conducted using Review Manager 5.4 and Comprehensive Meta-Analysis version 3 software.
   Results: A total of 9 studies with 19,660 diabetes mellitus patients who were infected by SARS-CoV-2 were included in the meta-analysis. Our data suggested that pre-admission use of GLP-1RA was associated with reduction in mortality rate from Covid-19 in patients with diabetes mellitus (OR 0.53; 95 %CI: 0.43-0.66, p < 0.00001, I-2 = 0%, random-effect modelling). Further analysis showed that the associations were not influenced by age (p = 0.213), gender (p = 0.421), hypertension (p = 0.131), cardiovascular disease (p = 0.293), nor the use of metformin (p = 0.189) and insulin (p = 0.117).
   Conclusions: Our study suggests that pre-admission use of GLP-1RA may offer beneficial effects on Covid-19 mortality in patients with diabetes mellitus. However, more randomized clinical trials are required to confirm this conclusion. (C) 2021 Elsevier B.V. All rights reserved.
C1 [Hariyanto, Timotius Ivan; Intan, Denny; Hananto, Joshua Edward; Putri, Cynthia] Pelita Harapan Univ, Fac Med, Karawaci 15811, Tangerang, Indonesia.
   [Kurniawan, Andree] Pelita Harapan Univ, Fac Med, Dept Internal Med, Blvd Jendral Sudirman St, Karawaci 15811, Tangerang, Indonesia.
C3 Universitas Pelita Harapan; Universitas Pelita Harapan
RP Kurniawan, A (通讯作者)，Pelita Harapan Univ, Fac Med, Dept Internal Med, Blvd Jendral Sudirman St, Karawaci 15811, Tangerang, Indonesia.
EM andree.kurniawan@uph.edu
RI Kurniawan, Andree/AAP-9471-2020; Putri, Cynthia/HDO-0791-2022;
   Hariyanto, Timotius Ivan/ABI-2074-2020
OI Kurniawan, Andree/0000-0002-5219-9029; Hariyanto, Timotius
   Ivan/0000-0002-1748-9776
CR Aroda VR, 2018, DIABETES OBES METAB, V20, P22, DOI 10.1111/dom.13162
   Belancic A, 2021, CLIN OBES, V11, DOI 10.1111/cob.12439
   Belancic Andrej, 2020, Obes Med, V20, P100302, DOI 10.1016/j.obmed.2020.100302
   Bettermann K, 2020, SSRN ELECT J, DOI [10.2139/ssrn.3725612, DOI 10.2139/SSRN.3725612]
   Blackman A, 2016, INT J OBESITY, V40, P1310, DOI 10.1038/ijo.2016.52
   Bornstein SR, 2020, LANCET DIABETES ENDO, V8, P546, DOI 10.1016/S2213-8587(20)30152-2
   Cariou B, 2020, DIABETOLOGIA, V63, P1500, DOI 10.1007/s00125-020-05180-x
   Codo AC, 2020, CELL METAB, V32, P437, DOI 10.1016/j.cmet.2020.07.007
   Davies MJ, 2015, JAMA-J AM MED ASSOC, V314, P687, DOI 10.1001/jama.2015.9676
   Drucker DJ, 2020, ENDOCR REV, V41, P457, DOI 10.1210/endrev/bnaa011
   Egger M, 1997, BMJ-BRIT MED J, V315, P629, DOI 10.1136/bmj.315.7109.629
   Erener S, 2020, MOL METAB, V39, DOI 10.1016/j.molmet.2020.101044
   Gabery S, 2020, JCI INSIGHT, V5, DOI 10.1172/jci.insight.133429
   Haffner SM, 2006, AM J CARDIOL, V97, p3A, DOI 10.1016/j.amjcard.2005.11.010
   Hariyanto TI, 2021, S AFR J HIV MED, V22, DOI 10.4102/sajhivmed.v22i1.1220
   Hariyanto TI, 2021, NUTR METAB CARDIOVAS, V31, P1662, DOI 10.1016/j.numecd.2021.02.020
   Hariyanto TI, 2022, REV MED VIROL, V32, DOI 10.1002/rmv.2265
   Hariyanto TI, 2021, SLEEP MED, V82, P47, DOI 10.1016/j.sleep.2021.03.029
   Hariyanto TI, 2021, J DIABETES METAB DIS, V20, P543, DOI 10.1007/s40200-021-00777-4
   Hariyanto TI, 2021, CLIN EXP PHARMACOL P, V48, P823, DOI 10.1111/1440-1681.13488
   Hariyanto TI, 2021, DRUG RES, V71, P265, DOI 10.1055/a-1336-2371
   Hariyanto TI, 2021, J MED VIROL, V93, P1832, DOI 10.1002/jmv.26698
   Hariyanto Timotius Ivan, 2020, Obes Med, V19, P100290, DOI 10.1016/j.obmed.2020.100290
   Hariyanto TI, 2020, DIABETES METAB SYND, V14, P1463, DOI 10.1016/j.dsx.2020.07.054
   Huang Y, 2020, METABOLISM, V113, DOI 10.1016/j.metabol.2020.154378
   Israelsen SB, 2021, DIABETES OBES METAB, V23, P1397, DOI 10.1111/dom.14329
   Izzi-Engbeaya C, 2021, BMJ OPEN DIAB RES CA, V9, DOI 10.1136/bmjdrc-2020-001858
   Jin TR, 2020, ACTA PHARM SIN B, V10, P1249, DOI 10.1016/j.apsb.2020.05.006
   Ku HC, 2010, N-S ARCH PHARMACOL, V382, P463, DOI 10.1007/s00210-010-0559-9
   Kuba K, 2006, J MOL MED, V84, P814, DOI 10.1007/s00109-006-0094-9
   Lee YS, 2016, MEDIAT INFLAMM, V2016, DOI 10.1155/2016/3094642
   Lim S, 2021, NAT REV ENDOCRINOL, V17, P11, DOI 10.1038/s41574-020-00435-4
   Ramos-Rincon JM, 2021, J GERONTOL A-BIOL, V76, pE102, DOI 10.1093/gerona/glab124
   Margulis AV, 2014, CLIN EPIDEMIOL, V6, P359, DOI 10.2147/CLEP.S66677
   Mirabelli M, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17103664
   Monda VM, 2020, DIABETES THER, V11, P1909, DOI 10.1007/s13300-020-00898-8
   Orioli L, 2021, DIABETES METAB SYND, V15, P149, DOI 10.1016/j.dsx.2020.12.020
   Pang Juan, 2021, Obes Med, V22, P100312, DOI 10.1016/j.obmed.2020.100312
   Pi-Sunyer X, 2015, NEW ENGL J MED, V373, P11, DOI 10.1056/NEJMoa1411892
   Putri C, 2021, PARKINSONISM RELAT D, V87, P155, DOI 10.1016/j.parkreldis.2021.04.019
   Rogliani P, 2019, RESP MED, V154, P86, DOI 10.1016/j.rmed.2019.06.015
   Romani-Perez M, 2015, ENDOCRINOLOGY, V156, P3559, DOI 10.1210/en.2014-1685
   Silverii GA, 2021, NUTR METAB CARDIOVAS, V31, P396, DOI 10.1016/j.numecd.2020.09.028
   Sourij H, 2021, DIABETES OBES METAB, V23, P589, DOI 10.1111/dom.14256
   Toki S, 2018, J ALLERGY CLIN IMMUN, V142, P1515, DOI 10.1016/j.jaci.2017.11.043
   Viby NE, 2013, ENDOCRINOLOGY, V154, P4503, DOI 10.1210/en.2013-1666
   Wargny M, 2021, DIABETOLOGIA, V64, P778, DOI 10.1007/s00125-020-05351-w
   WHO, 2010, SCREENING DONATED BLOOD FOR TRANSFUSION: TRANSMISSIBLE INFECTIONS, P1
   Wu ZH, 2021, ACTA DIABETOL, V58, P139, DOI 10.1007/s00592-020-01546-0
   Zhao L, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00233
   Zhou F, 2016, EUR J PHARMACOL, V791, P735, DOI 10.1016/j.ejphar.2016.10.016
   Zhu T, 2015, INT J MOL SCI, V16, P20195, DOI 10.3390/ijms160920195
NR 52
TC 32
Z9 32
U1 1
U2 3
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0168-8227
EI 1872-8227
J9 DIABETES RES CLIN PR
JI Diabetes Res. Clin. Pract.
PD SEP
PY 2021
VL 179
AR 109031
DI 10.1016/j.diabres.2021.109031
EA SEP 2021
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA UR7MT
UT WOS:000696929400017
PM 34461139
OA Green Published, Bronze
DA 2023-06-08
ER

PT J
AU Li, CF
   Zhao, X
   Gu, XQ
   Chen, Y
   Yu, GZ
AF Li, Chaofu
   Zhao, Xing
   Gu, Xiaoqiang
   Chen, Ying
   Yu, Guanzhen
TI The Preventive Role of Hydrogen-Rich Water in Thioacetamide-Induced
   Cholangiofibrosis in Rat Assessed by Automated Histological
   Classification
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE H-2; cancer prevention; artificial intelligence; quality of life;
   cholangiofibrosis
ID CANCER PREVENTION; MOLECULAR-HYDROGEN; CHOLANGIOCARCINOMA;
   CHEMOPREVENTION; PROGRESSION; MORTALITY; METFORMIN; ASPIRIN; RISK
AB Background: Cholangiofibrosis is a controversial intrahepatic cholangial lesion that precedes the development of cholangiocarcinoma. Here, we demonstrate that molecular hydrogen (H-2) can be used to effectively prevent cholangiofibrosis.Methods: The safety and quality of life (QOL) of rats was firstly evaluated. H-2 was administered to rats subjected to thioacetamide (TAA)-induced cholangiofibrosis throughout the whole process. Then, rats were administrated with TAA for 3 months and then followed by H-2 intervention. Rat livers were harvested and assessed by light microscopy and convolutional neural network. RNA-seq was performed to analyze the genetic changes in these animal models.Results: Continuous use of H-2-rich water was safe and improved QOL.The incidence and average number of cholangiofibrosis in the liver were higher in the TAA group (100%, 12.0 +/- 10.07) than that in the H-2 group (57.1%, 2.86 +/- 5.43). The AI algorithm revealed higher Alesion/Aliver in the TAA group (19.6% +/- 9.01) than that in the H-2 group (7.54% +/- 11.0). RNA-seq analysis revealed that H-2 results in a decline in glycolysis. Moreover, in the third experiment, the incidence of microscopic or suspicious tumors and the ratio of liver lesions was decreased after long-term use of H-2 (12.5%, 0.57% +/- 0.45) compared with untreated group (100%, 0.98% +/- 0.73). A number of intestinal microbiota was changed after H-2 usage, including clostridiaceae_1, ruminococcus, turicibacter, coriobacteriales, actinobacteria, and firmicutes_bacterium.Conclusion: Hydrogen-rich water protects against liver injury and cholangiofibrosis and improved quality of life partially through regulating the composition of intestinal flora.
C1 [Li, Chaofu; Gu, Xiaoqiang; Yu, Guanzhen] Shanghai Univ Tradit Chinese Med, Longhua Hosp, Dept Oncol, Shanghai, Peoples R China.
   [Li, Chaofu] Guangxi Med Univ, Affiliated Hosp 4, Dept Oncol, Liuzhou, Peoples R China.
   [Zhao, Xing] Hubei Univ Arts & Sci, Affiliated Hosp, Xiangyang Cent Hosp, Dept Oncol, Xiangyang, Peoples R China.
   [Chen, Ying] Changhai Hosp, Dept Pathol, Shanghai, Peoples R China.
   [Yu, Guanzhen] East China Normal Univ, Shanghai Key Lab Multidimens Informat Proc, Shanghai, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine; Guangxi Medical
   University; Hubei University of Arts & Science; Naval Medical
   University; East China Normal University
RP Yu, GZ (通讯作者)，Shanghai Univ Tradit Chinese Med, Longhua Hosp, Dept Oncol, Shanghai, Peoples R China.; Yu, GZ (通讯作者)，East China Normal Univ, Shanghai Key Lab Multidimens Informat Proc, Shanghai, Peoples R China.
EM gzyu@cee.ecnu.edu.cn
FU National Natural Science Foundation of China [81972721]
FX Funding This research was partly supported by the projects from National
   Natural Science Foundation of China (No. 81972721).
CR Adams ET, 2011, TOXICOL PATHOL, V39, P240, DOI 10.1177/0192623310391680
   Albini A, 2016, CLIN CANCER RES, V22, P4322, DOI 10.1158/1078-0432.CCR-16-0695
   Binda C, 2018, DIGEST LIVER DIS, V50, P421, DOI 10.1016/j.dld.2018.02.012
   Bode AM, 2016, NATL SCI REV, V3, P117, DOI 10.1093/nsr/nwv054
   Chan AT, 2016, LANCET ONCOL, V17, P407, DOI 10.1016/S1470-2045(16)00006-1
   Chen HY, 2014, AM J CANCER RES, V4, P89
   Chen WQ, 2016, CA-CANCER J CLIN, V66, P115, DOI 10.3322/caac.21338
   Dehmer SP, 2015, ASPIRIN USE PREVENT
   DOLE M, 1975, SCIENCE, V190, P152, DOI 10.1126/science.1166304
   Dwyer BJ, 2021, J HEPATOL, V74, P860, DOI 10.1016/j.jhep.2020.11.018
   Edgar RC, 2013, NAT METHODS, V10, P996, DOI [10.1038/nmeth.2604, 10.1038/NMETH.2604]
   Gao YS, 2014, BMC CANCER, V14, DOI 10.1186/1471-2407-14-520
   Hickling KC, 2010, TOXICOL PATHOL, V38, P213, DOI 10.1177/0192623309357945
   Higurashi T, 2016, LANCET ONCOL, V17, P475, DOI 10.1016/S1470-2045(15)00565-3
   Ichihara M, 2015, MED GAS RES, V5, DOI 10.1186/s13618-015-0035-1
   Itoh T, 2011, BIOCHEM BIOPH RES CO, V411, P143, DOI 10.1016/j.bbrc.2011.06.116
   Jiao N, 2018, PHYSIOL GENOMICS, V50, P244, DOI 10.1152/physiolgenomics.00114.2017
   Krogius-Kurikka L, 2009, BMC MICROBIOL, V9, DOI 10.1186/1471-2180-9-68
   Li C., 2019, ACAD J CHIN PLA MED, V40, P586, DOI [10.3969/j.issn.2095-5227.2019.06.018, DOI 10.3969/J.ISSN.2095-5227.2019.06.018]
   Lu YL, 2015, ENVIRON INT, V77, P5, DOI 10.1016/j.envint.2014.12.010
   Mangtani P, 2010, BRIT J CANCER, V102, P1438, DOI 10.1038/sj.bjc.6605645
   Molokhia EA, 2008, PRIMARY CARE, V35, P609, DOI 10.1016/j.pop.2008.07.009
   Ohsawa I, 2007, NAT MED, V13, P688, DOI 10.1038/nm1577
   Ohta S, 2011, CURR PHARM DESIGN, V17, P2241, DOI 10.2174/138161211797052664
   Rizvi S, 2018, NAT REV CLIN ONCOL, V15, P95, DOI 10.1038/nrclinonc.2017.157
   Rondanina G, 2017, BREAST, V34, P108, DOI 10.1016/j.breast.2017.05.008
   Rothwell PM, 2012, LANCET, V379, P1591, DOI 10.1016/S0140-6736(12)60209-8
   Rothwell PM, 2010, LANCET, V376, P1741, DOI 10.1016/S0140-6736(10)61543-7
   Runtuwene J, 2015, PEERJ, V3, DOI 10.7717/peerj.859
   Saitoh Y, 2008, ONCOL RES, V17, P247, DOI 10.3727/096504008786991620
   Unno T, 2015, J MICROBIOL BIOTECHN, V25, P431, DOI 10.4014/jmb.1408.08063
   Walczak K, 2017, POSTEP HIG MED DOSW, V71, P149
   [王革芳 Wang Gefang], 2018, [第二军医大学学报, Academic Journal of Second Military Medical University], V39, P285
   Xie MH, 2017, J AGR FOOD CHEM, V65, P10185, DOI 10.1021/acs.jafc.7b03992
   Ye J, 2008, BIOL PHARM BULL, V31, P19, DOI 10.1248/bpb.31.19
   Yeh CN, 2004, CARCINOGENESIS, V25, P631, DOI 10.1093/carcin/bgh037
   Zhang J, 2018, FRONT PHARMACOL, V9, DOI 10.3389/fphar.2018.00847
   Zhao LQ, 2011, INT J BIOL SCI, V7, P297, DOI 10.7150/ijbs.7.297
NR 38
TC 1
Z9 2
U1 1
U2 10
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD AUG 20
PY 2021
VL 12
AR 632045
DI 10.3389/fphar.2021.632045
PG 12
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA XM5AR
UT WOS:000728840300001
PM 34489690
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Takada, K
   Shimokawa, M
   Takamori, S
   Shimamatsu, S
   Hirai, F
   Tagawa, T
   Okamoto, T
   Hamatake, M
   Tsuchiya-Kawano, Y
   Otsubo, K
   Inoue, K
   Yoneshima, Y
   Tanaka, K
   Okamoto, I
   Nakanishi, Y
   Mori, M
AF Takada, Kazuki
   Shimokawa, Mototsugu
   Takamori, Shinkichi
   Shimamatsu, Shinichiro
   Hirai, Fumihiko
   Tagawa, Tetsuzo
   Okamoto, Tatsuro
   Hamatake, Motoharu
   Tsuchiya-Kawano, Yuko
   Otsubo, Kohei
   Inoue, Koji
   Yoneshima, Yasuto
   Tanaka, Kentaro
   Okamoto, Isamu
   Nakanishi, Yoichi
   Mori, Masaki
TI Clinical impact of probiotics on the efficacy of anti-PD-1 monotherapy
   in patients with nonsmall cell lung cancer: A multicenter retrospective
   survival analysis study with inverse probability of treatment weighting
SO INTERNATIONAL JOURNAL OF CANCER
LA English
DT Article
DE Nivolumab; nonsmall cell lung cancer; pembrolizumab; probiotics;
   prognostic factor
ID PROMOTES ANTITUMOR IMMUNITY; OPEN-LABEL; DOCETAXEL; NIVOLUMAB;
   METFORMIN; PEMBROLIZUMAB; ATEZOLIZUMAB; ANTIBODY; CHEMOTHERAPY;
   MICROBIOME
AB The gastrointestinal microbiota was reported as an important factor for the response to cancer immunotherapy. Probiotics associated with gastrointestinal dysbiosis and bacterial richness may affect the efficacy of cancer immunotherapy drugs. However, the clinical impact of probiotics on the efficacy of cancer immunotherapy in patients with nonsmall cell lung cancer (NSCLC) is poorly understood. The outcomes of 294 patients with advanced or recurrent NSCLC who received antiprogrammed cell death-1 (PD-1) therapy (nivolumab or pembrolizumab monotherapy) at three medical centers in Japan were analyzed in our study. We used inverse probability of treatment weighting (IPTW) to minimize the bias arising from the patients' backgrounds. The IPTW-adjusted Kaplan-Meier curves showed that progression-free survival (nonuse vs use: hazard ratio [HR] [95% confidence interval {CI}] = 1.73 [1.42-2.11], log-rank test P = .0229), but not overall survival (nonuse vs use: HR [95%CI] = 1.40 [1.13-1.74], log-rank test P = .1835), was significantly longer in patients who received probiotics. Moreover, the IPTW-adjusted univariate analyses showed that nonuse or use of probiotics was significantly associated with disease control (nonuse vs use: odds ratio [OR] [95%CI] = 0.51 [0.35-0.74], P = .0004) and overall response (nonuse vs use: OR [95%CI] = 0.43 [0.29-0.63], P < .0001). In this multicenter and retrospective study, probiotics use was associated with favorable clinical outcomes in patients with advanced or recurrent NSCLC who received anti-PD-1 monotherapy. The findings should be validated in a future prospective study.
C1 [Takada, Kazuki; Shimamatsu, Shinichiro; Hirai, Fumihiko; Hamatake, Motoharu] Kitakyushu Municipal Med Ctr, Dept Thorac Surg, Fukuoka, Japan.
   [Shimokawa, Mototsugu] Yamaguchi Univ, Dept Biostat, Grad Sch Med, Yamaguchi, Japan.
   [Takamori, Shinkichi; Okamoto, Tatsuro] Natl Hosp Org Kyushu Canc Ctr, Dept Thorac Oncol, Fukuoka, Fukuoka, Japan.
   [Tagawa, Tetsuzo; Mori, Masaki] Kyushu Univ, Grad Sch Med Sci, Dept Surg & Sci, Fukuoka, Fukuoka, Japan.
   [Tsuchiya-Kawano, Yuko; Otsubo, Kohei; Inoue, Koji; Nakanishi, Yoichi] Kitakyushu Municipal Med Ctr, Dept Resp Med, Fukuoka, Japan.
   [Yoneshima, Yasuto; Tanaka, Kentaro; Okamoto, Isamu] Kyushu Univ, Res Inst Dis Chest, Grad Sch Med Sci, Fukuoka, Fukuoka, Japan.
C3 Yamaguchi University; Kyushu Cancer Center; Kyushu University; Kyushu
   University
RP Takada, K (通讯作者)，Kitakyushu Municipal Med Ctr, Dept Thorac Surg, Kokurakita Ku, 2-1-1 Bashaku, Kitakyushu, Fukuoka 8028561, Japan.
EM k_takada@surg2.med.kyushu-u.ac.jp
RI FUMIHIKO, HIRAI/GXF-5357-2022
OI Hamatake, Motoharu/0000-0002-7643-5444; Tanaka,
   Kentaro/0000-0003-4602-4465
CR Afzal MZ, 2019, LUNG CANCER MANAG, V8, DOI 10.2217/lmt-2018-0016
   Afzal MZ, 2018, J IMMUNOTHER CANCER, V6, DOI 10.1186/s40425-018-0375-1
   Antonia SJ, 2019, LANCET ONCOL, V20, P1395, DOI 10.1016/S1470-2045(19)30407-3
   Borghaei H, 2015, NEW ENGL J MED, V373, P1627, DOI 10.1056/NEJMoa1507643
   Brahmer J, 2015, NEW ENGL J MED, V373, P123, DOI 10.1056/NEJMoa1504627
   Brahmer JR, 2012, NEW ENGL J MED, V366, P2455, DOI 10.1056/NEJMoa1200694
   Cha JH, 2018, MOL CELL, V71, P606, DOI 10.1016/j.molcel.2018.07.030
   Chalabi M, 2020, ANN ONCOL, V31, P525, DOI [10.1016/j.annonc.2020.01.006, 10.1016/j.annoc.2020.01.006]
   Derosa L, 2018, ANN ONCOL, V29, P1437, DOI 10.1093/annonc/mdy103
   Deschasaux M, 2018, NAT MED, V24, P1526, DOI 10.1038/s41591-018-0160-1
   Eisenhauer EA, 2009, EUR J CANCER, V45, P228, DOI 10.1016/j.ejca.2008.10.026
   Facchinetti F, 2020, EUR J CANCER, V130, P155, DOI 10.1016/j.ejca.2020.02.023
   Fehrenbacher L, 2016, LANCET, V387, P1837, DOI 10.1016/S0140-6736(16)00587-0
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Garon EB, 2015, NEW ENGL J MED, V372, P2018, DOI 10.1056/NEJMoa1501824
   Gopalakrishnan V, 2018, SCIENCE, V359, P97, DOI 10.1126/science.aan4236
   Herbst RS, 2016, LANCET, V387, P1540, DOI 10.1016/S0140-6736(15)01281-7
   Herbst RS, 2014, NATURE, V515, P563, DOI 10.1038/nature14011
   Huang XZ, 2019, ONCOIMMUNOLOGY, V8, DOI 10.1080/2162402X.2019.1665973
   Kazandjian D, 2016, ONCOLOGIST, V21, P634, DOI 10.1634/theoncologist.2015-0507
   Kim SH, 2017, J INVEST DERMATOL, V137, P1740, DOI 10.1016/j.jid.2017.03.033
   Lang D, 2019, TARGET ONCOL, V14, P707, DOI 10.1007/s11523-019-00679-9
   Marchetti A, 2016, J THORAC ONCOL, V11, P487, DOI 10.1016/j.jtho.2015.12.111
   Matson V, 2018, SCIENCE, V359, P104, DOI 10.1126/science.aao3290
   Miao RX, 2018, EXP THER MED, V15, P1081, DOI 10.3892/etm.2017.5461
   Mok TSK, 2019, LANCET, V393, P1819, DOI 10.1016/S0140-6736(18)32409-7
   Munoz-Garach A, 2016, ENDOCRINOL NUTR, V63, P560, DOI 10.1016/j.endonu.2016.07.008
   Nagai Y, 2005, CANCER RES, V65, P7276, DOI 10.1158/0008-5472.CAN-05-0331
   Pardoll DM, 2012, NAT REV CANCER, V12, P252, DOI 10.1038/nrc3239
   Reck M, 2019, J CLIN ONCOL, V37, P537, DOI 10.1200/JCO.18.00149
   Reck M, 2016, NEW ENGL J MED, V375, P1823, DOI 10.1056/NEJMoa1606774
   Rittmeyer A, 2017, LANCET, V389, P255, DOI 10.1016/S0140-6736(16)32517-X
   Routy B, 2018, SCIENCE, V359, P91, DOI 10.1126/science.aan3706
   Rubin DB, 2000, J AM STAT ASSOC, V95, P573, DOI 10.2307/2669400
   Scharping NE, 2017, CANCER IMMUNOL RES, V5, P9, DOI 10.1158/2326-6066.CIR-16-0103
   Sen S, 2018, ANN ONCOL, V29, P2396, DOI 10.1093/annonc/mdy453
   Sivan A, 2015, SCIENCE, V350, P1084, DOI 10.1126/science.aac4255
   Sugihara M, 2010, PHARM STAT, V9, P21, DOI 10.1002/pst.365
   Suresh K, 2018, J THORAC ONCOL, V13, P1930, DOI 10.1016/j.jtho.2018.08.2035
   Svaton M, 2020, ANTICANCER RES, V40, P2209, DOI 10.21873/anticanres.14182
   Teraoka S, 2017, J THORAC ONCOL, V12, P1798, DOI 10.1016/j.jtho.2017.08.022
   Tomita Y, 2020, CANCER IMMUNOL RES, V8, P1236, DOI 10.1158/2326-6066.CIR-20-0051
   Topalian SL, 2012, NEW ENGL J MED, V366, P2443, DOI 10.1056/NEJMoa1200690
   Wang DY, 2020, ONCOLOGIST, V25, pE602, DOI 10.1634/theoncologist.2019-0518
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Xie J, 2005, STAT MED, V24, P3089, DOI 10.1002/sim.2174
   Zhao X, 2017, ANN ONCOL, V28, P2002, DOI 10.1093/annonc/mdx235
NR 47
TC 22
Z9 23
U1 4
U2 18
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0020-7136
EI 1097-0215
J9 INT J CANCER
JI Int. J. Cancer
PD JUL 15
PY 2021
VL 149
IS 2
BP 473
EP 482
DI 10.1002/ijc.33557
EA MAR 2021
PG 10
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA SE6OR
UT WOS:000632925700001
PM 33720422
OA Bronze
DA 2023-06-08
ER

PT J
AU Li, QP
   Dou, YX
   Huang, ZW
   Chen, HB
   Li, YC
   Chen, JN
   Liu, YH
   Huang, XQ
   Zeng, HF
   Yang, XB
   Su, ZR
   Xie, JH
AF Li, Qiao-Ping
   Dou, Yao-Xing
   Huang, Zi-Wei
   Chen, Han-Bin
   Li, Yu-Cui
   Chen, Jian-Nan
   Liu, Yu-Hong
   Huang, Xiao-Qi
   Zeng, Hui-Fang
   Yang, Xiao-Bo
   Su, Zi-Ren
   Xie, Jian-Hui
TI Therapeutic effect of oxyberberine on obese non-alcoholic fatty liver
   disease rats
SO PHYTOMEDICINE
LA English
DT Article
DE Non-alcoholic fatty liver disease; Obesity; Oxyberberine; Berberine;
   Insulin signaling pathway; AMPK signaling pathway
ID ACTIVATED PROTEIN-KINASE; INSULIN-RESISTANCE; ADIPOSE-TISSUE; BERBERINE;
   AMPK; INHIBITION; MECHANISMS; PHARMACOLOGY; METABOLISM; GUIDELINES
AB Background: Berberine (BBR) has been widely used to treat non-alcoholic fatty liver disease (NAFLD). The metabolites of BBR were believed to contribute significantly to its pharmacological effects. Oxyberberine (OBB), a gut microbiota-mediated oxidative metabolite of BBR, has been firstly identified in our recent work.
   Purpose: Here, we aimed to comparatively investigate the anti-NAFLD properties of OBB and BBR.
   Methods: The anti-NAFLD effect was evaluated in high-fat diet-induced obese NAFLD rats with biochemical/ ELISA tests and histological staining. The related gene and protein expressions were detected by qRT-PCR and Western blotting respectively. Molecular docking and dynamic simulation were also performed to provide further insight.
   Results: Results indicated OBB remarkably and dose-dependently attenuated the clinical manifestations of NAFLD, which (100 mg/kg) achieved similar therapeutic effect to metformin (300 mg/kg) and was superior to BBR of the same dose. OBB significantly inhibited aberrant phosphorylation of IRS-1 and up-regulated the downstream protein expression and phosphorylation (PI3K, p-Akt/Akt and p-GSK-3 ss/GSK-3 ss) to improve hepatic insulin signal transduction. Meanwhile, OBB treatment remarkably alleviated inflammation via downregulating the mRNA expression of MCP-1, Cd68, Nos2, Cd11c, while enhancing Arg1 mRNA expression in white adipose tissue. Moreover, OBB exhibited closer affinity with AMPK in silicon and superior hyperphosphorylation of AMPK in vivo, leading to increased ACC mRNA expression in liver and UCP-1 protein expression in adipose tissue.
   Conclusion: Taken together, compared with BBR, OBB was more capable of maintaining lipid homeostasis between liver and WAT via attenuating hepatic insulin pathway and adipocyte inflammation, which was associated with its property of superior AMPK activator.
C1 [Li, Qiao-Ping; Dou, Yao-Xing; Li, Yu-Cui; Chen, Jian-Nan; Liu, Yu-Hong; Huang, Xiao-Qi; Su, Zi-Ren] Guangzhou Univ Chinese Med, Sch Pharmaceut Sci, Guangzhou 510006, Peoples R China.
   [Huang, Zi-Wei; Zeng, Hui-Fang] Guangzhou Univ Chinese Med, Affiliated Hosp Chinese Med 1, Guangzhou 510405, Peoples R China.
   [Chen, Han-Bin] Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau, Peoples R China.
   [Yang, Xiao-Bo; Xie, Jian-Hui] Guangzhou Univ Chinese Med, Affiliated Hosp 2, Guangzhou 510120, Peoples R China.
   [Yang, Xiao-Bo; Xie, Jian-Hui] Guangzhou Univ Chinese Med, State Key Lab Dampness Syndrome Chinese Med, Affiliated Hosp 2, Guangzhou 510120, Peoples R China.
   [Xie, Jian-Hui] Guangdong Prov Key Lab Clin Res Tradit Chinese Me, Guangzhou 510120, Peoples R China.
C3 Guangzhou University of Chinese Medicine; Guangzhou University of
   Chinese Medicine; University of Macau; Guangzhou University of Chinese
   Medicine; Guangzhou University of Chinese Medicine; Guangzhou University
   of Chinese Medicine
RP Su, ZR (通讯作者)，Guangzhou Univ Chinese Med, Sch Pharmaceut Sci, Guangzhou 510006, Peoples R China.; Xie, JH (通讯作者)，Guangzhou Univ Chinese Med, Affiliated Hosp 2, Guangzhou 510120, Peoples R China.; Xie, JH (通讯作者)，Guangzhou Univ Chinese Med, State Key Lab Dampness Syndrome Chinese Med, Affiliated Hosp 2, Guangzhou 510120, Peoples R China.; Xie, JH (通讯作者)，Guangdong Prov Key Lab Clin Res Tradit Chinese Me, Guangzhou 510120, Peoples R China.
EM suziren@gzucm.edu.cn; xiejianhui@gzucm.edu.cn
RI Liu, Yuhong/Y-4597-2019; yang, xiao/HJI-7815-2023; Liu,
   Yuhong/AAT-9680-2021; Xiaoqi, Huang/AAK-7124-2020
OI Liu, Yuhong/0000-0001-8070-6369; Xiaoqi, Huang/0000-0003-3401-5000;
   chen, han bin/0000-0003-2271-7769
FU National Science Foundation of China [82074082, 81673845]; Key Program
   for Subject Research of Guangzhou University of Chinese Medicine
   [XK2019002]; Characteristic Cultivation Program for Subject Research of
   Guangzhou University of Chinese Medicine [XKP2019007]; Guangdong
   Provincial Research and Demonstration Project for Ecological Restoration
   and Function Improvement Techniques of Mangrove [2020B020214001];
   Special Project of State Key Laboratory of Dampness Syndrome of Chinese
   Medicine [SZ2020ZZ03]; Key-Area Research and Development Program of
   Guangdong Province [2020B1111100010]; Science and Technology Research
   Project of Guangdong Provincial Hospital of Chinese Medicine
   [YN2018ZD02]; Guangdong Natural Science Foundation [2021A1515011490,
   2019A1515010819]
FX This research was financed by grants from National Science Foundation of
   China (No. 82074082 & No. 81673845), Key Program for Subject Research of
   Guangzhou University of Chinese Medicine (No. XK2019002), Characteristic
   Cultivation Program for Subject Research of Guangzhou University of
   Chinese Medicine (No. XKP2019007), Guangdong Provincial Research and
   Demonstration Project for Ecological Restoration and Function
   Improvement Techniques of Mangrove (2020B020214001), Special Project of
   State Key Laboratory of Dampness Syndrome of Chinese Medicine (No.
   SZ2020ZZ03), Key-Area Research and Development Program of Guangdong
   Province (No. 2020B1111100010), and Science and Technology Research
   Project of Guangdong Provincial Hospital of Chinese Medicine
   (YN2018ZD02), Guangdong Natural Science Foundation (Nos. 2021A1515011490
   & 2019A1515010819).
CR Akash MSH, 2018, J CELL BIOCHEM, V119, P105, DOI 10.1002/jcb.26174
   Antonopoulos AS, 2017, CARDIOVASC RES, V113, P1074, DOI 10.1093/cvr/cvx106
   Bessone F, 2019, CELL MOL LIFE SCI, V76, P99, DOI 10.1007/s00018-018-2947-0
   Birkenfeld AL, 2014, HEPATOLOGY, V59, P713, DOI 10.1002/hep.26672
   Boden G, 2008, ENDOCRIN METAB CLIN, V37, P635, DOI 10.1016/j.ecl.2008.06.007
   Brunt EM, 2011, HEPATOLOGY, V53, P810, DOI 10.1002/hep.24127
   Bustin SA, 2009, CLIN CHEM, V55, P611, DOI 10.1373/clinchem.2008.112797
   Cameron KO, 2016, J MED CHEM, V59, P8068, DOI 10.1021/acs.jmedchem.6b00866
   Cao SJ, 2013, J ETHNOPHARMACOL, V149, P576, DOI 10.1016/j.jep.2013.07.025
   Carling D, 2017, CURR OPIN CELL BIOL, V45, P31, DOI 10.1016/j.ceb.2017.01.005
   Chen KK, 2014, APOPTOSIS, V19, P946, DOI 10.1007/s10495-014-0977-0
   Chi JF, 1996, BRIT J PHARMACOL, V118, P503, DOI 10.1111/j.1476-5381.1996.tb15431.x
   Chopra I, 2012, DIABETOLOGIA, V55, P783, DOI 10.1007/s00125-011-2407-y
   Cicero AFG, 2018, NUTRIENTS, V10, DOI 10.3390/nu10091153
   Cohen P, 2004, NAT REV DRUG DISCOV, V3, P479, DOI 10.1038/nrd1415
   Cole BK, 2018, EXPERT OPIN DRUG DIS, V13, P193, DOI 10.1080/17460441.2018.1410135
   Corey KE, 2014, CLIN LIVER DIS, V18, P1, DOI 10.1016/j.cld.2013.09.019
   Day EA, 2017, TRENDS ENDOCRIN MET, V28, P545, DOI 10.1016/j.tem.2017.05.004
   de I'Hortet AC, 2019, CELL METAB, V30, P385, DOI 10.1016/j.cmet.2019.06.017
   Demine S, 2019, CELLS-BASEL, V8, DOI 10.3390/cells8080795
   Dou YX, 2021, BIOMED PHARMACOTHER, V137, DOI 10.1016/j.biopha.2021.111312
   Duwaerts CC, 2019, CELL MOL GASTROENTER, V7, P749, DOI 10.1016/j.jcmgh.2019.02.001
   Dyson JK, 2014, FRONTLINE GASTROENTE, V5, P211, DOI 10.1136/flgastro-2013-100403
   El-Zeftawy M, 2019, J FOOD BIOCHEM, V43, DOI 10.1111/jfbc.13049
   Engin AB, 2017, ADV EXP MED BIOL, V960, P197, DOI 10.1007/978-3-319-48382-5_8
   Feng XJ, 2019, THERANOSTICS, V9, P1923, DOI 10.7150/thno.30787
   Forli S, 2016, NAT PROTOC, V11, P905, DOI 10.1038/nprot.2016.051
   Friedman SL, 2018, NAT MED, V24, P908, DOI 10.1038/s41591-018-0104-9
   Green CJ, 2019, DIABETES OBES METAB, V21, P749, DOI 10.1111/dom.13592
   Guo T, 2016, SCI REP-UK, V6, DOI 10.1038/srep22612
   Hu XF, 2018, AM J TRANSL RES, V10, P3322
   Huang TH, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18071408
   Kim J, 2016, EXP MOL MED, V48, DOI 10.1038/emm.2016.16
   Kusminski CM, 2016, NAT REV DRUG DISCOV, V15, P639, DOI 10.1038/nrd.2016.75
   Li CL, 2019, PHYTOMEDICINE, V52, P272, DOI 10.1016/j.phymed.2018.09.228
   Li CL, 2020, PHARMACOL RES, V152, DOI 10.1016/j.phrs.2019.104603
   Li Y, 2011, J TRANSL MED, V9, DOI 10.1186/1479-5876-9-62
   Li YY, 2019, COMPUT BIOL CHEM, V79, P165, DOI 10.1016/j.compbiolchem.2019.02.007
   Liu YT, 2010, DRUG METAB DISPOS, V38, P1779, DOI 10.1124/dmd.110.033936
   Liu YH, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-05996-5
   Lou TJ, 2011, INFLAMMATION, V34, P659, DOI 10.1007/s10753-010-9276-2
   Mancini SJ, 2017, MOL CELL ENDOCRINOL, V440, P44, DOI 10.1016/j.mce.2016.11.010
   Manning BD, 2017, CELL, V169, P381, DOI 10.1016/j.cell.2017.04.001
   Marchesini G, 2016, J HEPATOL, V64, P1388, DOI 10.1016/j.jhep.2015.11.004
   MISIK V, 1995, PLANTA MED, V61, P372, DOI 10.1055/s-2006-958107
   Ning JY, 2010, MOL ENDOCRINOL, V24, P1218, DOI 10.1210/me.2009-0474
   Pang B, 2015, INT J ENDOCRINOL, V2015, DOI 10.1155/2015/905749
   Parker R., 2018, LIVER RES, V2, P35, DOI [10.1016/j.livres.2018.02.002, DOI 10.1016/J.LIVRES.2018.02.002]
   Patel S, 2004, BIOCHEM SOC T, V32, P803, DOI 10.1042/BST0320803
   Petersen MC, 2018, PHYSIOL REV, V98, P2133, DOI 10.1152/physrev.00063.2017
   Petroni ML, 2021, BMJ-BRIT MED J, V372, DOI 10.1136/bmj.m4747
   Qiang XY, 2016, BIOCHEM BIOPH RES CO, V472, P603, DOI 10.1016/j.bbrc.2016.03.019
   Russo L, 2018, IMMUNOLOGY, V155, P407, DOI 10.1111/imm.13002
   Samuel VT, 2018, CELL METAB, V27, P22, DOI 10.1016/j.cmet.2017.08.002
   Sengupta B, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0179777
   Singh Amitabh, 2009, Journal of Plant Protection Research, V49, P287, DOI 10.2478/v10045-009-0046-9
   Singh S, 2016, PHARM BIOL, V54, P740, DOI 10.3109/13880209.2015.1073334
   Tan HL, 2016, FRONT PHARMACOL, V7, DOI 10.3389/fphar.2016.00362
   Tan LH, 2019, INT IMMUNOPHARMACOL, V75, DOI 10.1016/j.intimp.2019.105802
   Titchenell PM, 2017, TRENDS ENDOCRIN MET, V28, P497, DOI 10.1016/j.tem.2017.03.003
   Wang GX, 2015, TRENDS ENDOCRIN MET, V26, P231, DOI 10.1016/j.tem.2015.03.002
   Wang H., 2018, ONCOTARGET, V9, P10135, DOI [10.18632/oncotarget, DOI 10.18632/ONCOTARGET.20807]
   Wang J, 2019, PHARM BIOL, V57, P193, DOI 10.1080/13880209.2019.1577466
   Winder WW, 1999, AM J PHYSIOL-ENDOC M, V277, pE1, DOI 10.1152/ajpendo.1999.277.1.E1
   Zhang JW, 2012, CURR DRUG METAB, V13, P558, DOI 10.2174/1389200211209050558
   Zhang YP, 2019, CURR MED SCI, V39, P37, DOI 10.1007/s11596-019-1997-3
   Zhang ZB, 2018, FRONT PHARMACOL, V9, DOI 10.3389/fphar.2018.01181
   Zhang ZB, 2018, FOOD FUNCT, V9, P2005, DOI [10.1039/c7fo02048a, 10.1039/C7FO02048A]
   Zhang ZG, 2014, NAT COMMUN, V5, DOI 10.1038/ncomms6493
   Zhu XP, 2016, MOLECULES, V21, DOI 10.3390/molecules21101336
NR 70
TC 12
Z9 13
U1 7
U2 46
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0944-7113
EI 1618-095X
J9 PHYTOMEDICINE
JI Phytomedicine
PD MAY
PY 2021
VL 85
AR 153550
DI 10.1016/j.phymed.2021.153550
EA APR 2021
PG 12
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA RN1IG
UT WOS:000640107200048
PM 33831691
DA 2023-06-08
ER

PT J
AU Jullig, M
   Yip, S
   Xu, AM
   Smith, G
   Middleditch, M
   Booth, M
   Babor, R
   Beban, G
   Murphy, R
AF Juellig, Mia
   Yip, Shelley
   Xu, Aimin
   Smith, Greg
   Middleditch, Martin
   Booth, Michael
   Babor, Richard
   Beban, Grant
   Murphy, Rinki
TI Lower Fetuin-A, Retinol Binding Protein 4 and Several Metabolites after
   Gastric Bypass Compared to Sleeve Gastrectomy in Patients with Type 2
   Diabetes
SO PLOS ONE
LA English
DT Article
ID INSULIN-RESISTANCE; BARIATRIC SURGERY; GUT MICROBIOTA; SERUM
   RETINOL-BINDING-PROTEIN-4; GLUCOSE-METABOLISM; CITRATE METABOLISM;
   OBESITY; CHILDREN; MARKERS; TISSUE
AB Background: Bypass of foregut secreted factors promoting insulin resistance is hypothesized to be one of the mechanisms by which resolution of type 2 diabetes (T2D) follows roux-en-y gastric bypass (GBP) surgery. Aim: To identify insulin resistance-associated proteins and metabolites which decrease more after GBP than after sleeve gastrectomy (SG) prior to diabetes remission.
   Methods: Fasting plasma from 15 subjects with T2D undergoing GBP or SG was analyzed by proteomic and metabolomic methods 3 days before and 3 days after surgery. Subjects were matched for age, BMI, metformin therapy and glycemic control. Insulin resistance was calculated using homeostasis model assessment (HOMA-IR). For proteomics, samples were depleted of abundant plasma proteins, digested with trypsin and labeled with iTRAQ isobaric tags prior to liquid chromatography-tandem mass spectrometry analysis. Metabolomic analysis was performed using gas chromatography-mass spectrometry. The effect of the respective bariatric surgery on identified proteins and metabolites was evaluated using two-way analysis of variance and appropriate post-hoc tests.
   Results: HOMA-IR improved, albeit not significantly, in both groups after surgery. Proteomic analysis yielded seven proteins which decreased significantly after GBP only, including Fetuin-A and Retinol binding protein 4, both previously linked to insulin resistance. Significant decrease in Fetuin-A and Retinol binding protein 4 after GBP was confirmed using ELISA and immunoassay. Metabolomic analysis identified significant decrease of citrate, proline, histidine and decanoic acid specifically after GBP.
   Conclusion: Greater early decrease was seen for Fetuin-A, Retinol binding protein 4, and several metabolites after GBP compared to SG, preceding significant weight loss. This may contribute to enhanced T2D remission observed following foregut bypass procedures.
C1 [Juellig, Mia; Middleditch, Martin] Univ Auckland, Maurice Wilkins Ctr Mol Biodiscovery, Auckland 1, New Zealand.
   [Juellig, Mia; Middleditch, Martin] Univ Auckland, Sch Biol Sci, Auckland 1, New Zealand.
   [Yip, Shelley; Murphy, Rinki] Univ Auckland, Dept Med, Auckland, New Zealand.
   [Xu, Aimin] Univ Hong Kong, Dept Med, Dept Pharmacol & Pharm, Hong Kong, Hong Kong, Peoples R China.
   [Smith, Greg] Univ New S Wales, Dept Pharmacol, Sydney, NSW, Australia.
   [Booth, Michael] North Shore Hosp, Dept Surg, Auckland, New Zealand.
   [Babor, Richard] Middlemore Hosp, Dept Surg, Auckland 6, New Zealand.
   [Beban, Grant] Auckland City Hosp, Dept Surg, Auckland, New Zealand.
C3 University of Auckland; University of Auckland; University of Auckland;
   University of Hong Kong; University of New South Wales Sydney; Auckland
   City Hospital
RP Murphy, R (通讯作者)，Univ Auckland, Dept Med, Auckland, New Zealand.
EM R.Murphy@auckland.ac.nz
FU Jens Henrick Jensen fund; NovoNordisk Diabetes grant fund
FX This work was supported by the Jens Henrick Jensen fund and the
   NovoNordisk Diabetes grant fund. The funders had no role in study
   design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
CR Abbatini F, 2010, SURG ENDOSC, V24, P1005, DOI 10.1007/s00464-009-0715-9
   Adeva MM, 2012, AMINO ACIDS, V43, P171, DOI 10.1007/s00726-011-1088-7
   Alapatt P, 2013, J BIOL CHEM, V288, P1250, DOI 10.1074/jbc.M112.369132
   Aron-Wisnewsky J, 2012, NAT REV GASTRO HEPAT, V9, P590, DOI 10.1038/nrgastro.2012.161
   Blonder J, 2011, ELECTROPHORESIS, V32, P1541, DOI 10.1002/elps.201000585
   Brix JM, 2010, J CLIN ENDOCR METAB, V95, P4877, DOI 10.1210/jc.2010-0148
   Buchwald H, 2009, AM J MED, V122, P248, DOI 10.1016/j.amjmed.2008.09.041
   Christou GA, 2012, HORM METAB RES, V44, P6, DOI 10.1055/s-0031-1295491
   Cummings DE, 2009, INT J OBESITY, V33, pS33, DOI 10.1038/ijo.2009.15
   Cummings DE, 2007, SURG OBES RELAT DIS, V3, P109, DOI 10.1016/j.soard.2007.02.003
   Cupisti A, 2007, BIOMED PHARMACOTHER, V61, P86, DOI 10.1016/j.biopha.2006.09.012
   DEVILLIERS DC, 1966, METABOLIS, V15, P458, DOI 10.1016/0026-0495(66)90088-6
   Fiehn O, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0015234
   Friedrich N, 2012, J ENDOCRINOL, V215, P29, DOI 10.1530/JOE-12-0120
   Gall WE, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0010883
   Gomez-Ambrosi J, 2008, CLIN ENDOCRINOL, V69, P208, DOI 10.1111/j.1365-2265.2007.03156.x
   Graham TE, 2006, NEW ENGL J MED, V354, P2552, DOI 10.1056/NEJMoa054862
   GROOP LC, 1991, J CLIN ENDOCR METAB, V72, P96, DOI 10.1210/jcem-72-1-96
   Gunduz FO, 2011, DIABETES METAB J, V35, P523, DOI 10.4093/dmj.2011.35.5.523
   Huffman KM, 2009, DIABETES CARE, V32, P1678, DOI 10.2337/dc08-2075
   Isken F, 2006, HORM METAB RES, V38, P543, DOI 10.1055/s-2006-949528
   Janke J, 2006, DIABETES, V55, P2805, DOI 10.2337/db06-0616
   Jullig M, 2010, PROTEOMICS, V10, P3367, DOI 10.1002/pmic.201000276
   Khoo CM, 2013, ANN SURG
   Kong LC, 2013, AM J CLIN NUTR, V98, P16, DOI 10.3945/ajcn.113.058743
   Li HK, 2008, J PROTEOME RES, V7, P4775, DOI 10.1021/pr800352k
   Li W, 2011, PLOS ONE, V6, DOI [10.1371/journal.pone.0016945, 10.1371/journal.pone.0021082]
   Li X, 2009, ANAL CHIM ACTA, V633, P257, DOI 10.1016/j.aca.2008.11.058
   Merrell Karen, 2004, J Biomol Tech, V15, P238
   Millioni R, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0019603
   Mori K, 2012, ADV CLIN CHEM, V56, P175, DOI 10.1016/B978-0-12-394317-0.00010-8
   Mutch DM, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0007905
   Oberbach A, 2012, J LAPAROENDOSC ADV S, V22, P184, DOI 10.1089/lap.2011.0115
   Oberbach A, 2011, J PROTEOME RES, V10, P4769, DOI 10.1021/pr2005555
   Ou HY, 2011, CLIN ENDOCRINOL, V75, P450, DOI 10.1111/j.1365-2265.2011.04070.x
   Pal D, 2012, NAT MED, V18, P1279, DOI 10.1038/nm.2851
   Patil DP, 2012, J BIOSCIENCES, V37, P647, DOI 10.1007/s12038-012-9244-0
   Peterli R, 2009, ANN SURG, V250, P234, DOI 10.1097/SLA.0b013e3181ae32e3
   Petrescu O, 2005, INT J OBESITY, V29, P196, DOI 10.1038/sj.ijo.0802868
   Rao RS, 2012, OBES REV, V13, P316, DOI 10.1111/j.1467-789X.2011.00955.x
   Reinehr T, 2008, J CLIN ENDOCR METAB, V93, P4479, DOI 10.1210/jc.2008-1505
   Rubino F, 2004, ANN SURG, V240, P236, DOI 10.1097/01.sla.0000133117.12646.48
   Sjostrom L, 2008, INT J OBESITY, V32, pS93, DOI 10.1038/ijo.2008.244
   Stefan N, 2008, DIABETES, V57, P2762, DOI 10.2337/db08-0538
   Tuttolomondo A, 2010, ATHEROSCLEROSIS, V208, P290, DOI 10.1016/j.atherosclerosis.2009.07.032
   Wang Haichao, 2008, Expert Reviews in Molecular Medicine, V10, P1, DOI 10.1017/S1462399408000884
   Weikert C, 2008, CIRCULATION, V118, P2555, DOI 10.1161/CIRCULATIONAHA.108.814418
   Wickremesekera K, 2005, OBES SURG, V15, P474, DOI 10.1381/0960892053723402
   Yang Q, 2005, NATURE, V436, P356, DOI 10.1038/nature03711
   Yip S, 2014, OBES SURG, V24, P62, DOI 10.1007/s11695-013-1043-7
NR 50
TC 37
Z9 37
U1 1
U2 8
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 6
PY 2014
VL 9
IS 5
AR e96489
DI 10.1371/journal.pone.0096489
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA AJ9KS
UT WOS:000338029800077
PM 24800810
OA Green Submitted, Green Published, gold
DA 2023-06-08
ER

PT J
AU Tilves, C
   Yeh, HC
   Maruthur, N
   Juraschek, SP
   Miller, E
   White, K
   Appel, LJ
   Mueller, NT
AF Tilves, Curtis
   Yeh, Hsin-Chieh
   Maruthur, Nisa
   Juraschek, Stephen P.
   Miller, Edgar
   White, Karen
   Appel, Lawrence J.
   Mueller, Noel T.
TI Increases in Circulating and Fecal Butyrate are Associated With Reduced
   Blood Pressure and Hypertension: Results From the SPIRIT Trial
SO JOURNAL OF THE AMERICAN HEART ASSOCIATION
LA English
DT Article
DE acetic acid; blood pressure; butyric acid; fatty acids, volatile;
   hypertension
ID CHAIN FATTY-ACIDS; SEX-DIFFERENCES; GUT MICROBIOME; OVERWEIGHT
AB BACKGROUND: Short chain fatty acids (SCFAs) are microbially derived end products of dietary fiber fermentation. The SCFA butyrate reduces blood pressure (BP) in mouse models. The association of SCFAs, including butyrate, with BP in humans is unclear, due in part to predominantly cross-sectional analyses and different biospecimens (blood versus fecal) for SOFA measurement. Longitudinal studies including both circulating and fecal SCFAs are lacking.
   METHODS AND RESULTS: We leveraged existing data from the SPIRIT (Survivorship Promotion In Reducing IGF-1 Trial), which randomized 121 adult cancer survivors with overweight/obesity to a behavioral weight-loss intervention, metformin, or self-directed weight-loss. Of participants with baseline serum and fecal SCFAs measured (n=111), a subset had serum (n=93) and fecal (n=89) SCFA measurements 12 months later. We used Poisson regression with robust error variance to estimate baseline associations of SCFAs with hypertension, and we assessed the percent change in SCFAs from baseline with corresponding 12-month changes in BP using multiple linear regression. Baseline fecal butyrate was inversely associated with prevalent hypertension (standardized PR [95%CI]: 0.71 [0.54, 0.92]). A 10% increase in fecal butyrate from baseline was associated with decreased systolic BP (beta [95%CI]: -0.56 [-1.01, -0.10] mm Hg), and a 10% increase in serum butyrate was associated with decreased systolic (beta [95%CI]: -1.39 [-2.15, -0.63] mm Hg) and diastolic (beta [95%CI]: -0.55 [-1.03, -0.08] mm Hg) BPs. Butyrate associations with systolic BP were linear and not modified by sex, race, or intervention arm.
   CONCLUSIONS: Increased serum or fecal butyrate is associated with lowered BP. Butyrate may be a target for SOFA-centered BP-lowering interventions.
C1 [Tilves, Curtis; Miller, Edgar; Appel, Lawrence J.; Mueller, Noel T.] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA.
   [Tilves, Curtis; Yeh, Hsin-Chieh; Maruthur, Nisa; White, Karen; Appel, Lawrence J.; Mueller, Noel T.] Johns Hopkins Univ, Welch Ctr Prevent Epidemiol & Clin Res, Baltimore, MD USA.
   [Juraschek, Stephen P.] Beth Israel Deaconess Med Ctr, Div Gen Med & Primary Care, Boston, MA 02215 USA.
C3 Johns Hopkins University; Johns Hopkins Bloomberg School of Public
   Health; Johns Hopkins University; Harvard University; Beth Israel
   Deaconess Medical Center
RP Mueller, NT (通讯作者)，2024 E Monument St,Suite 2-600,Room 2-636, Baltimore, MD 21205 USA.
EM nmuelle4@jhu.edu
RI Appel, Larry/GLT-2608-2022
OI Appel, Lawrence/0000-0002-0673-6823; Mueller, Noel/0000-0002-7412-8352;
   Miller, Edgar/0000-0003-0157-6258; Juraschek,
   Stephen/0000-0003-4168-2696
FU Maryland Cigarette Restitution Fund; National Heart, Lung, and Blood
   Institute [T32HL007024, K01HL141589]; National Cancer Institute's Cancer
   Centers Support Grant [5P30CA006973]
FX The SPIRIT study was funded by the Maryland Cigarette Restitution Fund.
   N.T.M. was supported by the National Heart, Lung, and Blood Institute
   (K01HL141589). H.C.Y. was supported in part by the National Cancer
   Institute's Cancer Centers Support Grant to the Sidney Kimmel
   Comprehensive Cancer Center at Johns Hopkins (5P30CA006973). C.T. was
   supported by the National Heart, Lung, and Blood Institute grant
   T32HL007024.
CR Bobb JF, 2018, ENVIRON HEALTH-GLOB, V17, DOI 10.1186/s12940-018-0413-y
   Bobb JF, 2015, BIOSTATISTICS, V16, P493, DOI 10.1093/biostatistics/kxu058
   Bolnick DI, 2014, NAT COMMUN, V5, DOI 10.1038/ncomms5500
   Buckley JP, 2017, ENVIRON HEALTH PERSP, V125, DOI 10.1289/EHP334
   Calderon-Perez L, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-63475-w
   Chambers ES, 2015, GUT, V64, P1744, DOI 10.1136/gutjnl-2014-307913
   Chang YL, 2020, CLIN SCI, V134, P289, DOI 10.1042/CS20191253
   Chen L, 2020, HYPERTENSION, V76, P73, DOI 10.1161/HYPERTENSIONAHA.120.14800
   de la Cuesta-Zuluaga J, 2019, NUTRIENTS, V11, DOI 10.3390/nu11010051
   Gillis EE, 2016, HYPERTENSION, V68, P1322, DOI 10.1161/HYPERTENSIONAHA.116.06602
   Harrell Jr FE, 2017, RMS REGRESSION MODEL
   Huart J, 2019, HYPERTENSION, V74, P1005, DOI 10.1161/HYPERTENSIONAHA.118.12588
   Kaye DM, 2020, CIRCULATION, V141, P1393, DOI 10.1161/CIRCULATIONAHA.119.043081
   Kim S, 2018, CLIN SCI, V132, P701, DOI [10.1042/CS20180087, 10.1042/cs20180087]
   Klein SL, 2016, NAT REV IMMUNOL, V16, P626, DOI 10.1038/nri.2016.90
   Lin HV, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0035240
   Liu H, 2018, ADV NUTR, V9, P21, DOI 10.1093/advances/nmx009
   Lu YY, 2016, SCI REP-UK, V6, DOI 10.1038/srep37589
   Markle JGM, 2013, SCIENCE, V339, P1084, DOI 10.1126/science.1233521
   Mueller NT, 2021, DIABETES CARE, V44, P1462, DOI 10.2337/dc20-2257
   Mueller NT, 2020, AM J CLIN NUTR, V111, P545, DOI 10.1093/ajcn/nqz322
   Muller M, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-48775-0
   Onyszkiewicz M, 2019, PFLUG ARCH EUR J PHY, V471, P1441, DOI 10.1007/s00424-019-02322-y
   Venegas DP, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.00277
   Pluznick JL, 2017, CURR HYPERTENS REP, V19, DOI 10.1007/s11906-017-0722-5
   Poll BG, 2020, PHYSIOLOGY, V35, P275, DOI 10.1152/physiol.00004.2020
   Rahat-Rozenbloom S, 2014, INT J OBESITY, V38, P1525, DOI 10.1038/ijo.2014.46
   Regitz-Zagrosek V, 2017, PHYSIOL REV, V97, P1, DOI 10.1152/physrev.00021.2015
   Robles-Vera I, 2020, MOL NUTR FOOD RES, V64, DOI 10.1002/mnfr.201900616
   Schwiertz A, 2010, OBESITY, V18, P190, DOI 10.1038/oby.2009.167
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Verhaar BJH, 2020, EUR HEART J, V41, P4259, DOI 10.1093/eurheartj/ehaa704
   Vijay A, 2021, FRONT CARDIOVASC MED, V8, DOI 10.3389/fcvm.2021.691564
   Wallis A, 2016, SCI REP-UK, V6, DOI 10.1038/srep19171
   Whelton PK, 2018, HYPERTENSION, V71, pE13, DOI [10.1161/HYP.0000000000000065, 10.1161/HYP.0000000000000066]
   Wilck N, 2017, NATURE, V551, P585, DOI 10.1038/nature24628
   Yang T, 2019, ACTA PHYSIOL, V226, DOI 10.1111/apha.13256
   Yeh HC, 2021, J CLIN ENDOCR METAB, V106, pE4179, DOI 10.1210/clinem/dgab266
   Zhao GH, 2006, BIOMED CHROMATOGR, V20, P674, DOI 10.1002/bmc.580
NR 39
TC 2
Z9 2
U1 3
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2047-9980
J9 J AM HEART ASSOC
JI J. Am. Heart Assoc.
PD JUL 5
PY 2022
VL 11
IS 13
AR e024763
DI 10.1161/JAHA.121.024763
PG 22
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 2R3YF
UT WOS:000821048200027
PM 35730613
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Wang, X
   Kang, JH
   Liu, Q
   Tong, T
   Quan, HL
AF Wang, Xin
   Kang, Jinhong
   Liu, Qing
   Tong, Tao
   Quan, Helong
TI Fighting Diabetes Mellitus: Pharmacological and Non-pharmacological
   Approaches
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Review
DE Diabetes mellitus; cyclic adenosine monophosphate; G protein-coupled
   receptors; peroxisome proliferator activated-receptor gamma;
   sodium-glucose cotransporters; 2,5 '-adenosine monophosphate-activated
   protein kinase; glucagon-like peptide-1 receptor; glucose homeostasis
ID PROTEIN-COUPLED RECEPTORS; HEPATIC GLUCOSE-PRODUCTION; LIFE-STYLE
   INTERVENTION; GLUCAGON-LIKE PEPTIDE-1; INSULIN-RESISTANCE; PPAR-GAMMA;
   INTESTINAL MICROBIOTA; THERAPEUTIC TARGET; METABOLIC SYNDROME; TYPE-2
AB Background: The increasing worldwide prevalence of diabetes mellitus confers heavy public health issues and points to a large medical need for effective and novel anti-diabetic approaches with negligible adverse effects. Developing effective and novel anti-diabetic approaches to curb diabetes is one of the most foremost scientific challenges.
   Objectives: This article aims to provide an overview of current pharmacological and non-pharmacological approaches available for the management of diabetes mellitus.
   Methods: Research articles that focused on pharmacological and non-pharmacological interventions for diabetes were collected from various search engines such as Science Direct and Scopus, using keywords like diabetes, glucagon-like peptide-1, glucose homeostasis, etc.
   Results: We review in detail several key pathways and pharmacological targets (e.g., the G protein-coupled receptors-cyclic adenosine monophosphate, 5'-adenosine monophosphate-activated protein kinase, sodium-glucose cotransporters 2, and peroxisome proliferator activated-receptor gamma signaling pathways) that are vital in the regulation of glucose homeostasis. The currently approved diabetes medications, the pharmacological potentials of naturally occurring compounds as promising interventions for diabetes, and the non-pharmacological methods designed to mitigate diabetes are summarized and discussed.
   Conclusion: Pharmacological-based approaches such as insulin, metformin, sodium-glucose cotransporters 2 inhibitor, sulfonylureas, glucagon-like peptide-1 receptor agonists, and dipeptidyl peptidase IV inhibitors represent the most important strategies in diabetes management. These approved diabetes medications work via targeting the central signaling pathways related to the etiology of diabetes. Non-pharmacological approaches, including dietary modification, increased physical activity, and micmbiota-based therapy are the other cornerstones for diabetes treatment. Pharmacological-based approaches may be incorporated when lifestyle modification alone is insufficient to achieve positive outcomes.
C1 [Wang, Xin; Tong, Tao] China Agr Univ, Coll Food Sci & Nutr Engn, Beijing Adv Innovat Ctr Food Nutr & Human Hlth, 17 Qinghua Donglu, Beijing 100083, Peoples R China.
   [Kang, Jinhong] Korea Univ, Coll Pharm, Sejong 30019, South Korea.
   [Liu, Qing] Jilin Green Food Engn Res Inst, Changchun 130022, Peoples R China.
   [Quan, Helong] Zhejiang Normal Univ, Coll Phys Educ & Hlth Sci, Exercise & Metab Res Ctr, 688 Yingbin Ave, Jinhua 321004, Zhejiang, Peoples R China.
C3 China Agricultural University; Korea University; Zhejiang Normal
   University
RP Tong, T (通讯作者)，China Agr Univ, Coll Food Sci & Nutr Engn, Beijing Adv Innovat Ctr Food Nutr & Human Hlth, 17 Qinghua Donglu, Beijing 100083, Peoples R China.; Quan, HL (通讯作者)，Zhejiang Normal Univ, Coll Phys Educ & Hlth Sci, Exercise & Metab Res Ctr, 688 Yingbin Ave, Jinhua 321004, Zhejiang, Peoples R China.
EM tongtao1028@cau.edu.cn; quanhelong@zjnu.edu.cn
RI Tong, Tao/Q-8856-2016
OI Tong, Tao/0000-0002-9309-2893; Quan, Helong/0000-0002-7665-5930
FU Zhejiang Education Department General Project of China [KYZ04Y18258]
FX The study was funded by Zhejiang Education Department General Project of
   China, (No. KYZ04Y18258).
CR Acharjee S, 2013, CAN J DIABETES, V37, P269, DOI 10.1016/j.jcjd.2013.05.001
   Aguayo-Mazzucato C, 2018, CELL METAB, V27, P57, DOI 10.1016/j.cmet.2017.08.007
   Ahren B, 2009, NAT REV DRUG DISCOV, V8, P369, DOI 10.1038/nrd2782
   Ahren B, 2008, VASC HEALTH RISK MAN, V4, P383, DOI 10.2147/VHRM.S1944
   Allen JA, 2005, MOL PHARMACOL, V67, P1493, DOI 10.1124/mol.104.008342
   Allin KH, 2018, DIABETOLOGIA, V61, P810, DOI 10.1007/s00125-018-4550-1
   [Anonymous], QUEST ANSW REV PIOGL
   Bailey CJ, 2017, DIABETOLOGIA, V60, P1566, DOI 10.1007/s00125-017-4318-z
   Bansal G, 2020, J ADV RES, V23, P163, DOI 10.1016/j.jare.2020.01.008
   Blad CC, 2012, NAT REV DRUG DISCOV, V11, P603, DOI 10.1038/nrd3777
   Caesar R, 2019, CAN J DIABETES, V43, P224, DOI 10.1016/j.jcjd.2019.01.007
   Cao H, 2019, CRIT REV FOOD SCI, V59, P3371, DOI 10.1080/10408398.2018.1492900
   CARTEE GD, 1990, AM J PHYSIOL, V258, pE390, DOI 10.1152/ajpendo.1990.258.2.E390
   Chen M, 2005, P NATL ACAD SCI USA, V102, P7386, DOI 10.1073/pnas.0408268102
   Coughlan KA, 2014, DIABET METAB SYND OB, V7, P241, DOI 10.2147/DMSO.S43731
   D'Alessio DA, 2004, AM J PHYSIOL-ENDOC M, V286, pE882, DOI 10.1152/ajpendo.00014.2004
   Day EA, 2017, TRENDS ENDOCRIN MET, V28, P545, DOI 10.1016/j.tem.2017.05.004
   De Marinis YZ, 2010, CELL METAB, V11, P543, DOI 10.1016/j.cmet.2010.04.007
   DEFRONZO RA, 1992, DIABETES CARE, V15, P318, DOI 10.2337/diacare.15.3.318
   Diaz-Trastoy O, 2020, CLIN THER, V42, pE1, DOI 10.1016/j.clinthera.2019.12.012
   Ding WG, 1997, DIABETES, V46, P792, DOI 10.2337/diabetes.46.5.792
   dos Santos JM, 2015, METABOLISM, V64, P1619, DOI 10.1016/j.metabol.2015.09.013
   Dowarah J, 2020, BIOORGAN MED CHEM, V28, DOI 10.1016/j.bmc.2019.115263
   Drucker DJ, 2010, DIABETES CARE, V33, P428, DOI 10.2337/dc09-1499
   Duca FA, 2015, NAT MED, V21, P506, DOI 10.1038/nm.3787
   Elekofehinti Olusola Olalekan, 2015, Pathophysiology, V22, P95, DOI 10.1016/j.pathophys.2015.02.001
   Franz MJ, 2018, DIABETES METAB SYNDR, V11, P265, DOI 10.2147/DMSO.S141952
   Fruchter O, 2001, NEW ENGL J MED, V345, P696
   Garcia-Hermoso A, 2014, EUR J ENDOCRINOL, V171, pR163, DOI 10.1530/EJE-14-0291
   GONZALEZ GA, 1989, CELL, V59, P675, DOI 10.1016/0092-8674(89)90013-5
   Gregg EW, 2012, JAMA-J AM MED ASSOC, V308, P2489, DOI 10.1001/jama.2012.67929
   Gromada J, 1997, J GEN PHYSIOL, V110, P217, DOI 10.1085/jgp.110.3.217
   Gu JJ, 2012, J PHYSIOL PHARMACOL, V63, P505
   Guo SD, 2014, J ENDOCRINOL, V220, pT1, DOI 10.1530/JOE-13-0327
   Gurung M, 2020, EBIOMEDICINE, V51, DOI 10.1016/j.ebiom.2019.11.051
   Hahr Allison J, 2015, Clin Diabetes Endocrinol, V1, P2, DOI 10.1186/s40842-015-0001-9
   He JH, 2019, FITOTERAPIA, V134, P270, DOI 10.1016/j.fitote.2019.02.033
   He WM, 2003, P NATL ACAD SCI USA, V100, P15712, DOI 10.1073/pnas.2536828100
   HEDIGER MA, 1994, PHYSIOL REV, V74, P993, DOI 10.1152/physrev.1994.74.4.993
   Ivanova MI, 2009, P NATL ACAD SCI USA, V106, P18990, DOI 10.1073/pnas.0910080106
   Janani C, 2015, DIABETES METAB SYND, V9, P46, DOI 10.1016/j.dsx.2014.09.015
   JONES DT, 1989, SCIENCE, V244, P790, DOI 10.1126/science.2499043
   Kahn SE, 2014, LANCET, V383, P1068, DOI 10.1016/S0140-6736(13)62154-6
   Kaihara KA, 2015, DIABETES, V64, P1688, DOI 10.2337/db14-1051
   Kaihara KA, 2013, DIABETES, V62, P1527, DOI 10.2337/db12-1013
   Keung W, 2013, DIABETES, V62, P711, DOI 10.2337/db12-0259
   Khunti K, 2018, LANCET DIABETES ENDO, V6, P821, DOI 10.1016/S2213-8587(18)30025-1
   Kintscher U, 2005, AM J PHYSIOL-ENDOC M, V288, pE287, DOI 10.1152/ajpendo.00440.2004
   Klein J, 1999, J BIOL CHEM, V274, P34795, DOI 10.1074/jbc.274.49.34795
   Kootte RS, 2017, CELL METAB, V26, P611, DOI 10.1016/j.cmet.2017.09.008
   Langer O, 2018, AM J OBSTET GYNECOL, V218, P490, DOI 10.1016/j.ajog.2018.01.024
   Lee JH, 2015, J PHARM SCI-US, V104, P3049, DOI 10.1002/jps.24378
   Lee NJ, 2015, MOL METAB, V4, P164, DOI 10.1016/j.molmet.2014.12.010
   Li EW, 2019, CELL METAB, V30, P319, DOI 10.1016/j.cmet.2019.05.022
   Li G, 2020, EUR J MED CHEM, V188, DOI 10.1016/j.ejmech.2019.112017
   Li G, 2016, EUR J MED CHEM, V124, P103, DOI 10.1016/j.ejmech.2016.08.023
   Li WH, 2020, SEMIN CELL DEV BIOL, V103, P14, DOI 10.1016/j.semcdb.2020.02.002
   Lin HV, 2011, CELL METAB, V14, P9, DOI 10.1016/j.cmet.2011.06.003
   MacDonald PE, 2002, DIABETES, V51, pS434, DOI 10.2337/diabetes.51.2007.S434
   Miller RA, 2013, NATURE, V494, P256, DOI 10.1038/nature11808
   Mukaida S, 2017, PHARMACOL RES, V116, P87, DOI 10.1016/j.phrs.2016.12.022
   Muoio DM, 2008, NAT REV MOL CELL BIO, V9, P193, DOI 10.1038/nrm2327
   Nanjan MJ, 2018, BIOORG CHEM, V77, P548, DOI 10.1016/j.bioorg.2018.02.009
   Nauck M, 2009, DIABETES CARE, V32, P84, DOI 10.2337/dc08-1355
   Nevzorova J, 2006, BRIT J PHARMACOL, V147, P446, DOI 10.1038/sj.bjp.0706626
   Nevzorova J, 2002, BRIT J PHARMACOL, V137, P9, DOI 10.1038/sj.bjp.0704845
   O'Neill HM, 2011, P NATL ACAD SCI USA, V108, P16092, DOI 10.1073/pnas.1105062108
   Pan XR, 1997, DIABETES CARE, V20, P537, DOI 10.2337/diacare.20.4.537
   Papatheodorou K, 2016, J DIABETES RES, V2016, DOI 10.1155/2016/6989453
   Patel BM, 2019, EUR J PHARMACOL, V862, DOI 10.1016/j.ejphar.2019.172657
   Quintal A, 2019, DIABETES METAB, V45, P1, DOI 10.1016/j.diabet.2018.04.003
   Ramsay RR, 2018, CLIN TRANSL MED, V7, DOI 10.1186/s40169-017-0181-2
   Raveendran Arkiath V, 2018, Eur Endocrinol, V14, P31, DOI 10.17925/EE.2018.14.2.31
   Rege NK, 2017, CURR OPIN ENDOCRINOL, V24, P267, DOI 10.1097/MED.0000000000000345
   Richards P, 2014, DIABETES, V63, P1224, DOI 10.2337/db13-1440
   Rosen ED, 2001, J BIOL CHEM, V276, P37731, DOI 10.1074/jbc.R100034200
   Rosenstock J, 2015, DIABETES CARE, V38, P376, DOI 10.2337/dc14-1142
   Rourke JL, 2018, TRENDS ENDOCRIN MET, V29, P111, DOI 10.1016/j.tem.2017.11.007
   */* S  73, 2018, DIABETES CARE S1, V41, pS7, DOI DOI 10.2337/DC18-S008
   Saeedi P, 2019, DIABETES RES CLIN PR, V157, DOI 10.1016/j.diabres.2019.107843
   Samuel VT, 2012, CELL, V148, P852, DOI 10.1016/j.cell.2012.02.017
   Sato M, 2014, DIABETES, V63, P4115, DOI 10.2337/db13-1860
   Sebastiani G, 2018, BEST PRACT RES CL EN, V32, P201, DOI 10.1016/j.beem.2018.02.005
   Sharma AK, 2011, BRIT J NUTR, V106, P1713, DOI 10.1017/S000711451100225X
   Smith U, 2002, INT J OBESITY, V26, P897, DOI 10.1038/sj.ijo.0802028
   Storgaard H, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0166125
   Storz MA, 2020, CAN J DIABETES, V44, P301, DOI 10.1016/j.jcjd.2019.08.020
   Svegliati-Baroni G, 2011, LIVER INT, V31, P1285, DOI 10.1111/j.1478-3231.2011.02462.x
   THIAZOLIDINEDIO.YJ, 2004, NEW ENGL J MED, V351, P1106
   Thule PM, 2012, ADV PHYSIOL EDUC, V36, P275, DOI 10.1152/advan.00094.2012
   Toft-Nielsen MB, 2001, J CLIN ENDOCR METAB, V86, P3717, DOI 10.1210/jc.86.8.3717
   Tomaro ES, 2017, NUTR METAB CARDIOVAS, V27, P688, DOI 10.1016/j.numecd.2017.06.009
   Tong T, 2019, INT J OBESITY, V43, P202, DOI 10.1038/s41366-018-0176-0
   Tong T, 2018, NUTRIENTS, V10, DOI 10.3390/nu10111781
   Tong T, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-10379-x
   Tu Y Y, 1981, Yao Xue Xue Bao, V16, P366
   Ulloa-Aguirre A, 1999, ARCH MED RES, V30, P420, DOI 10.1016/S0188-0128(99)00041-X
   Underwood CR, 2010, J BIOL CHEM, V285, P723, DOI 10.1074/jbc.M109.033829
   VANBEERS EH, 1995, CRIT REV BIOCHEM MOL, V30, P197, DOI 10.3109/10409239509085143
   Vrieze A, 2012, GASTROENTEROLOGY, V143, P913, DOI 10.1053/j.gastro.2012.06.031
   Wang SB, 2016, PHARMACOL RES, V111, P76, DOI 10.1016/j.phrs.2016.02.028
   Whitlock RH, 2020, MAYO CLIN PROC, V95, P90, DOI 10.1016/j.mayocp.2019.07.017
   Xie T, 2007, P NATL ACAD SCI USA, V104, P19601, DOI 10.1073/pnas.0704796104
   Xu LN, 2018, PHARMACOL RES, V130, P451, DOI 10.1016/j.phrs.2018.01.015
   Xu X, 2014, EXPERT OPIN DRUG DIS, V9, P1047, DOI 10.1517/17460441.2014.941352
   Yang HH, 2016, J MOL ENDOCRINOL, V57, pR93, DOI 10.1530/JME-15-0316
   Zheng W, 2013, DRUG DISCOV TODAY, V18, P1067, DOI 10.1016/j.drudis.2013.07.001
   Zhou GC, 2001, J CLIN INVEST, V108, P1167, DOI 10.1172/JCI200113505
   Zhou TT, 2018, BIOMED PHARMACOTHER, V106, P1227, DOI 10.1016/j.biopha.2018.07.085
   Zimmet P, 2001, NATURE, V414, P782, DOI 10.1038/414782a
NR 110
TC 5
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PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PY 2020
VL 26
IS 39
BP 4992
EP 5001
DI 10.2174/1381612826666200728144200
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA OS5RV
UT WOS:000590221800005
PM 32723251
DA 2023-06-08
ER

PT J
AU Zhang, GL
   Zhang, PY
   Li, W
   Hao, FQ
   Chen, FM
   Yang, Y
   Hou, Y
   Tao, YT
AF Zhang Guilin
   Zhang Pengyu
   Li Wei
   Hao Fengqi
   Chen, Fangmei
   Yang Yu
   Hou Yue
   Tao Yuting
TI Reduction of gut microbial diversity and short chain fatty acids in
   BALB/c mice exposure to microcystin-LR
SO ECOTOXICOLOGY
LA English
DT Article
DE Microcystin; Gut microbiota; Metagenomics; Short-chain fatty acid
ID COLORECTAL-CANCER; DIETARY FIBER; BUTYRATE; GROWTH; DETOXIFICATION;
   CYANOBACTERIA; GLUTATHIONE; EXPRESSION; METFORMIN; RELEASE
AB Gut microbiota has been shown to play critical roles in host health. The present study was to determine the toxicological effects of microcystin-LR (MCLR) on gut microbial community and metabolites using 16S rDNA sequencing and gas chromatography-mass spectrometry (GC-MS). MCLR was administered to BALB/c mice by gavage for eight weeks. Results of the microbial alpha-diversity (Sobs, Chao1, ACE and Shannon indexes) decreased in MCLR-treated group versus controls. PhylumCandidatus Saccharibacteriadecreased significantly in MCLR-treated group versus controls. Correspondingly, more than thirties genera in relative abundance decreased, especially short chain fatty acid (SCFA)-producing bacteria (e.g.,AlistipesandRuminococcus). These results indicated that the gut microbial community structure was remarkably changed by MCLR. Furthermore, concentrations of SCFAs were significantly decreased after MCLR exposure (P < 0.01), where butyrate decreased as high as 4.9-fold. Consequently, sub-chronic exposure to MCLR could not only alter the microbial composition but metabolites. This study offered novel insights into the toxic mechanism of MCs from gut microbiota, and facilitated further clarification of risks to human health from MCs exposure.
C1 [Zhang Guilin; Zhang Pengyu; Li Wei; Hao Fengqi; Chen, Fangmei; Yang Yu; Hou Yue; Tao Yuting] Changchun Univ Sci & Technol, Sch Life Sci & Technol, Changchun 130022, Peoples R China.
   [Li Wei] Wuhan Haidian Foreign Language Shi Yan Sch, Wuhan 430220, Peoples R China.
C3 Changchun University of Science & Technology
RP Li, W (通讯作者)，Changchun Univ Sci & Technol, Sch Life Sci & Technol, Changchun 130022, Peoples R China.; Li, W (通讯作者)，Wuhan Haidian Foreign Language Shi Yan Sch, Wuhan 430220, Peoples R China.
EM liwei5695084@163.com
FU Youth Foundations of Changchun University of Science and Technology,
   China [XQNJJ-2016-16]; Science and Technology Research Project of Jilin
   Province, China [JJKH20181128KJ]; Undergraduate Innovation and
   Entrepreneurship Training Program of JiLin Province [201910186177,
   201910186187]
FX The project was supported by Youth Foundations of Changchun University
   of Science and Technology, China (XQNJJ-2016-16), Science and Technology
   Research Project of Jilin Province, China (JJKH20181128KJ) and
   Undergraduate Innovation and Entrepreneurship Training Program of JiLin
   Province (201910186177, 201910186187).
CR Amado LL, 2010, ENVIRON INT, V36, P226, DOI 10.1016/j.envint.2009.10.010
   Barcelo A, 2000, GUT, V46, P218, DOI 10.1136/gut.46.2.218
   Bates JM, 2007, CELL HOST MICROBE, V2, P371, DOI 10.1016/j.chom.2007.10.010
   Bingham SA, 2003, LANCET, V361, P1496, DOI 10.1016/S0140-6736(03)13174-1
   Botha N, 2004, TOXICON, V43, P251, DOI 10.1016/j.toxicon.2003.11.026
   Caliz J, 2012, CHEMOSPHERE, V89, P494, DOI 10.1016/j.chemosphere.2012.05.002
   Chen J, 2015, J TOXICOL SCI, V40, P485, DOI 10.2131/jts.40.485
   Chi YL, 2018, ENVIRON POLLUT, V239, P332, DOI 10.1016/j.envpol.2018.04.001
   Christen V, 2013, ENVIRON SCI TECHNOL, V47, P3378, DOI 10.1021/es304886y
   Cotillard A, 2013, NATURE, V500, P585, DOI 10.1038/nature12480
   Daien CI, 2017, FRONT IMMUNOL, V8, DOI 10.3389/fimmu.2017.00548
   Deutscher J, 2006, MICROBIOL MOL BIOL R, V70, P939, DOI 10.1128/MMBR.00024-06
   Ding WX, 2001, J TOXICOL ENV HEAL A, V64, P507, DOI 10.1080/152873901753215966
   Dixon RA, 2004, FEMS MICROBIOL LETT, V230, P167, DOI 10.1016/S0378-1097(03)00910-8
   Forslund K, 2017, NATURE, V545, P116, DOI 10.1038/nature22318
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Foxall TL, 1998, ALGAL TOXINS HLTH
   Goel A, 2014, J GASTROEN HEPATOL, V29, P1139, DOI 10.1111/jgh.12556
   Guo MZ, 2014, TOXICOL SCI, V141, P314, DOI 10.1093/toxsci/kfu128
   Guo XC, 2014, CHEMOSPHERE, V112, P1, DOI 10.1016/j.chemosphere.2014.03.068
   Hamer HM, 2008, ALIMENT PHARM THER, V27, P104, DOI 10.1111/j.1365-2036.2007.03562.x
   Hatayama H, 2007, BIOCHEM BIOPH RES CO, V356, P599, DOI 10.1016/j.bbrc.2007.03.025
   He J, 2017, ARCH TOXICOL, V91, P465, DOI 10.1007/s00204-016-1681-3
   He J, 2012, AQUAT TOXICOL, V116, P61, DOI 10.1016/j.aquatox.2012.03.004
   Horng YT, 2018, J MICROBIOL IMMUNOL, V51, P174, DOI 10.1016/j.jmii.2017.01.007
   Ito E, 2000, TOXICON, V38, P37, DOI 10.1016/S0041-0101(99)00084-7
   Langille MGI, 2013, NAT BIOTECHNOL, V31, P814, DOI 10.1038/nbt.2676
   Li HY, 2012, ENVIRON TOXICOL PHAR, V34, P324, DOI 10.1016/j.etap.2012.04.011
   Li W, 2018, CHEMOSPHERE, V191, P357, DOI 10.1016/j.chemosphere.2017.09.083
   LIN J.-A., 2015, THESIS
   Liu LuYi, 2014, Acta Hydrobiologica Sinica, V38, P533
   Lloyd CR, 2017, J BACTERIOL, V199, DOI 10.1128/JB.00869-16
   Loh G, 2012, GUT MICROBES, V3, P544, DOI 10.4161/gmic.22156
   Looft T, 2012, P NATL ACAD SCI USA, V109, P1691, DOI 10.1073/pnas.1120238109
   Mardinoglu A, 2016, CELL METAB, V23, P10, DOI 10.1016/j.cmet.2015.12.012
   Meijer HP, 2000, DIS COLON RECTUM, V43, P1427, DOI 10.1007/BF02236640
   Merel S, 2013, ENVIRON INT, V59, P303, DOI 10.1016/j.envint.2013.06.013
   Moreno IM, 2003, J PHYSIOL BIOCHEM, V59, P293, DOI 10.1007/BF03179887
   Mutlu EA, 2018, ENVIRON POLLUT, V240, P817, DOI 10.1016/j.envpol.2018.04.130
   NISHIWAKIMATSUSHIMA R, 1992, J CANCER RES CLIN, V118, P420, DOI 10.1007/BF01629424
   Park Y, 2005, JAMA-J AM MED ASSOC, V294, P2849, DOI 10.1001/jama.294.22.2849
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Ren ZG, 2019, GUT, V68, P1014, DOI 10.1136/gutjnl-2017-315084
   Roda A, 2007, WORLD J GASTROENTERO, V13, P1079, DOI 10.3748/wjg.v13.i7.1079
   Sands BE, 2007, J GASTROENTEROL, V42, P16, DOI 10.1007/s00535-006-1995-7
   Topping DL, 2001, PHYSIOL REV, V81, P1031, DOI 10.1152/physrev.2001.81.3.1031
   Vaishnava S, 2011, SCIENCE, V334, P255, DOI 10.1126/science.1209791
   Valdor R, 2007, TOXICON, V49, P769, DOI 10.1016/j.toxicon.2006.11.025
   Veldee MV, 1931, AM J PUBLIC HEALTH N, V21, P1227, DOI 10.2105/AJPH.21.11.1227
   Vonaesch P, 2018, P NATL ACAD SCI USA, V115, pE8489, DOI 10.1073/pnas.1806573115
   Wilck N, 2017, NATURE, V551, P585, DOI 10.1038/nature24628
   Wood R, 2016, ENVIRON INT, V91, P276, DOI 10.1016/j.envint.2016.02.026
   Wu BY, 2014, ECOTOX ENVIRON SAFE, V109, P70, DOI 10.1016/j.ecoenv.2014.08.002
   Wu Y., 2018, SCI REP, V8
   Yang Cui-Yun, 2008, Acta Hydrobiologica Sinica, V32, P818, DOI [10.3724/SP.J.0000.2008.60818, 10.3724/SP.J.1035.2008.00818]
   Yin NY, 2017, CHEMOSPHERE, V168, P358, DOI 10.1016/j.chemosphere.2016.10.091
   Yoshida Toshinori, 1997, Natural Toxins, V5, P91, DOI 10.1002/nt.1
   Zhang SQ, 2018, CHEMOSPHERE, V195, P108, DOI 10.1016/j.chemosphere.2017.12.067
   Zhang X, 2012, PLOS ONE, V7, DOI [10.1371/journal.pone.0040320, 10.1371/journal.pone.0042529]
   Zhao XY, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0167032
   Zhou Lun, 2000, Zhonghua Yufang Yixue Zazhi, V34, P224
NR 61
TC 11
Z9 12
U1 4
U2 26
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0963-9292
EI 1573-3017
J9 ECOTOXICOLOGY
JI Ecotoxicology
PD NOV
PY 2020
VL 29
IS 9
BP 1347
EP 1357
DI 10.1007/s10646-020-02254-9
EA AUG 2020
PG 11
WC Ecology; Environmental Sciences; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Toxicology
GA OF6YU
UT WOS:000557727500001
PM 32772242
DA 2023-06-08
ER

PT J
AU Ballan, R
   Saad, SMI
AF Ballan, Rafael
   Saad, Susana Marta Isay
TI Characteristics of the Gut Microbiota and Potential Effects of Probiotic
   Supplements in Individuals with Type 2 Diabetes mellitus
SO FOODS
LA English
DT Review
DE diabetes mellitus type 2; gut microbiota; microbial metabolites;
   dysbiosis; probiotics
ID TRIMETHYLAMINE-N-OXIDE; CHAIN AMINO-ACIDS; GLYCEMIC CONTROL;
   FATTY-ACIDS; GLUCOSE; RISK; METAANALYSIS; METFORMIN; OBESITY;
   ASSOCIATION
AB The increasing prevalence of type 2 diabetes mellitus (T2DM) worldwide has become a burden to healthcare systems. In 2019, around 463 million adults were living with diabetes mellitus, and T2DM accounted for 90 to 95% of cases. The relationship between the gut microbiota and T2DM has been explored with the advent of metagenomic techniques. Genome-wide association studies evaluating the microbiota of these individuals have pointed to taxonomic, functional, and microbial metabolite imbalances and represent a potential intervention in T2DM management. Several microbial metabolites and components, such as imidazole propionate, trimethylamine, and lipopolysaccharides, appear to impair insulin signaling, while short-chain fatty acids, secondary bile acids, and tryptophan metabolites may improve it. In addition, the use of probiotics with the aim of transiently restoring the microbial balance or reducing the effects of microbial metabolites that impair insulin sensitivity has been explored. Herein, we critically review the available literature on the changes in the gut microbiota in T2DM together with potential adjuvant therapies that may improve the health status of this population.
C1 [Ballan, Rafael; Saad, Susana Marta Isay] Univ Sao Paulo, Sch Pharmaceut Sci, Dept Pharmaceut & Biochem Technol, BR-05508000 Sao Paulo, SP, Brazil.
   [Ballan, Rafael; Saad, Susana Marta Isay] Univ Sao Paulo, Food Res Ctr, BR-05508080 Sao Paulo, SP, Brazil.
C3 Universidade de Sao Paulo; Universidade de Sao Paulo
RP Saad, SMI (通讯作者)，Univ Sao Paulo, Sch Pharmaceut Sci, Dept Pharmaceut & Biochem Technol, BR-05508000 Sao Paulo, SP, Brazil.; Saad, SMI (通讯作者)，Univ Sao Paulo, Food Res Ctr, BR-05508080 Sao Paulo, SP, Brazil.
EM Rafael.maluhy@gmail.com; susaad@usp.br
RI Saad, Susana Marta Isay/C-1354-2012
OI Saad, Susana Marta Isay/0000-0001-9682-8491
FU Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
   [2013/07914-8]; Coordenacao de Aperfeicoamento de Pessoal de Nivel
   Superior (CAPES) [88882.376365/2019-01]; Conselho Nacional de
   Desenvolvimento Cientifico e Tecnologico (CNPq) [305380/2019-2]
FX This work was supported by the Fundacao de Amparo a Pesquisa do Estado
   de Sao Paulo (FAPESP) under Grant number 2013/07914-8-FoRC-Food Research
   Center, by the Coordenacao de Aperfeicoamento de Pessoal de Nivel
   Superior (CAPES)-fellowship number 88882.376365/2019-01, and Conselho
   Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)-fellowship
   number 305380/2019-2.
CR Akbari M, 2020, INFLAMMOPHARMACOLOGY, V28, P345, DOI 10.1007/s10787-019-00663-9
   Amer Diabet Assoc, 2020, DIABETES CARE, V43, pS14, DOI 10.2337/dc20-S002
   Amer Diabet Assoc, 2014, DIABETES CARE, V37, pS81, DOI [10.2337/dc13-S067, 10.2337/dc14-S081, 10.2337/dc13-S011, 10.2337/dc10-S062, 10.2337/dc10-S011, 10.2337/dc11-S062, 10.2337/dc12-s064, 10.2337/dc11-S011]
   Asghari G, 2018, J DIABETES, V10, P357, DOI 10.1111/1753-0407.12639
   Berg G, 2020, MICROBIOME, V8, DOI 10.1186/s40168-020-00875-0
   Bicsak TA, 2017, DIABETES OBES METAB, V19, P1499, DOI 10.1111/dom.12994
   Canfora EE, 2015, NAT REV ENDOCRINOL, V11, P577, DOI 10.1038/nrendo.2015.128
   Chang CJ, 2019, J FOOD DRUG ANAL, V27, P615, DOI 10.1016/j.jfda.2018.12.011
   Chiang JYL, 2019, ANNU REV NUTR, V39, P175, DOI 10.1146/annurev-nutr-082018-124344
   Chimerel C, 2014, CELL REP, V9, P1202, DOI 10.1016/j.celrep.2014.10.032
   Cho NH, 2018, DIABETES RES CLIN PR, V138, P271, DOI 10.1016/j.diabres.2018.02.023
   de Mello VD, 2017, SCI REP-UK, V7, DOI 10.1038/srep46337
   Depommier C, 2019, NAT MED, V25, P1096, DOI 10.1038/s41591-019-0495-2
   Doumatey AP, 2020, FRONT CELL INFECT MI, V10, DOI 10.3389/fcimb.2020.00063
   Dujic T, 2016, DIABETIC MED, V33, P511, DOI 10.1111/dme.13040
   Esser N, 2014, DIABETES RES CLIN PR, V105, P141, DOI 10.1016/j.diabres.2014.04.006
   Everard A, 2014, ISME J, V8, P2116, DOI 10.1038/ismej.2014.45
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Firouzi S, 2017, EUR J NUTR, V56, P1535, DOI 10.1007/s00394-016-1199-8
   Galicia-Garcia U, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21176275
   Gao X, 2014, J BIOSCI BIOENG, V118, P476, DOI 10.1016/j.jbiosc.2014.03.001
   Gurung M, 2020, EBIOMEDICINE, V51, DOI 10.1016/j.ebiom.2019.11.051
   Hameed I, 2015, WORLD J DIABETES, V6, P598, DOI 10.4239/wjd.v6.i4.598
   Heianza Y, 2019, GUT, V68, P263, DOI 10.1136/gutjnl-2018-316155
   Hemert S. van, 2014, Food and Nutrition Sciences, V5, P1739
   Hill C, 2014, NAT REV GASTRO HEPAT, V11, P506, DOI 10.1038/nrgastro.2014.66
   Holst JJ, 2007, PHYSIOL REV, V87, P1409, DOI 10.1152/physrev.00034.2006
   Hsieh MC, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-35014-1
   Hummel S, 2012, APPL ENVIRON MICROB, V78, P1140, DOI 10.1128/AEM.06983-11
   Jennis M, 2018, NEUROGASTROENT MOTIL, V30, DOI 10.1111/nmo.13178
   Jia JZ, 2019, DIABETES, V68, P1747, DOI 10.2337/db19-0153
   Jia W, 2018, NAT REV GASTRO HEPAT, V15, P111, DOI 10.1038/nrgastro.2017.119
   Karczewski J, 2010, AM J PHYSIOL-GASTR L, V298, pG851, DOI 10.1152/ajpgi.00327.2009
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kerner W, 2014, EXP CLIN ENDOCR DIAB, V122, P384, DOI 10.1055/s-0034-1366278
   Khalili Leila, 2019, Iranian Biomedical Journal, V23, P68, DOI [10.29252/.23.1.68, 10.29252/ibj.23.1.68]
   Kobyliak N, 2018, DIABETES METAB SYND, V12, P617, DOI 10.1016/j.dsx.2018.04.015
   Kocsis T, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-68440-1
   Koh A, 2018, CELL, V175, P947, DOI 10.1016/j.cell.2018.09.055
   Kolb H, 2017, BMC MED, V15, DOI 10.1186/s12916-017-0901-x
   Kumar H, 2009, BIOCHEM BIOPH RES CO, V388, P621, DOI 10.1016/j.bbrc.2009.08.062
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Ley RE, 2005, P NATL ACAD SCI USA, V102, P11070, DOI 10.1073/pnas.0504978102
   Li Q, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-62224-3
   Lynch CJ, 2014, NAT REV ENDOCRINOL, V10, P723, DOI 10.1038/nrendo.2014.171
   Marchesi JR, 2016, GUT, V65, P330, DOI 10.1136/gutjnl-2015-309990
   Markowiak-Kopec P, 2020, NUTRIENTS, V12, DOI 10.3390/nu12041107
   Mazloom Z, 2013, IRAN J MED SCI, V38, P38
   Medzhitov R, 2008, NATURE, V454, P428, DOI 10.1038/nature07201
   Mobini R, 2017, DIABETES OBES METAB, V19, P579, DOI 10.1111/dom.12861
   Molinaro A, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-19589-w
   Morrison DJ, 2016, GUT MICROBES, V7, P189, DOI 10.1080/19490976.2015.1134082
   Munoz-Garach A, 2016, ENDOCRINOL NUTR, V63, P560, DOI 10.1016/j.endonu.2016.07.008
   Mutaguchi Y, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.01540
   Nagata C, 2013, AM J EPIDEMIOL, V178, P1226, DOI 10.1093/aje/kwt112
   Newgard CB, 2009, CELL METAB, V9, P311, DOI 10.1016/j.cmet.2009.02.002
   Ouwehand AC, 2017, BENEF MICROBES, V8, P143, DOI [10.3920/BM2016.0140, 10.3920/bm2016.0140]
   Palacios T, 2020, NUTRIENTS, V12, DOI 10.3390/nu12072041
   Pathak P, 2018, HEPATOLOGY, V68, P1574, DOI 10.1002/hep.29857
   Pedersen HK, 2016, NATURE, V535, P376, DOI 10.1038/nature18646
   Plovier H, 2017, NAT MED, V23, P107, DOI 10.1038/nm.4236
   Qi JQ, 2018, J CELL MOL MED, V22, P185, DOI 10.1111/jcmm.13307
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Roager HM, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-018-05470-4
   Rowland I, 2018, EUR J NUTR, V57, P1, DOI 10.1007/s00394-017-1445-8
   Sabico S, 2019, CLIN NUTR, V38, P1561, DOI 10.1016/j.clnu.2018.08.009
   Sabico S, 2017, J TRANSL MED, V15, DOI 10.1186/s12967-017-1354-x
   Salamon D, 2018, POL ARCH INTERN MED, V128, P336, DOI 10.20452/pamw.4246
   Saltiel AR, 2001, NATURE, V414, P799, DOI 10.1038/414799a
   Sanders ME, 2019, NAT REV GASTRO HEPAT, V16, P605, DOI 10.1038/s41575-019-0173-3
   Schneeberger M, 2015, SCI REP-UK, V5, DOI 10.1038/srep16643
   Sircana A, 2018, CURR DIABETES REP, V18, DOI 10.1007/s11892-018-1057-6
   Suez J, 2019, NAT MED, V25, P716, DOI 10.1038/s41591-019-0439-x
   Sun J, 2016, BRIT J NUTR, V115, P1167, DOI 10.1017/S0007114516000076
   Taesuwan S, 2017, J NUTR BIOCHEM, V45, P77, DOI 10.1016/j.jnutbio.2017.02.010
   Tang WHW, 2017, CLIN CHEM, V63, P297, DOI 10.1373/clinchem.2016.263640
   Tanimura N, 2008, BIOCHEM BIOPH RES CO, V368, P94, DOI 10.1016/j.bbrc.2008.01.061
   Tett A, 2019, CELL HOST MICROBE, V26, P666, DOI 10.1016/j.chom.2019.08.018
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Venkatesh M, 2014, IMMUNITY, V41, P296, DOI 10.1016/j.immuni.2014.06.014
   Wang JJ, 2020, J DIABETES RES, V2020, DOI 10.1155/2020/6047145
   Williams R, 2020, DIABETES RES CLIN PR, V162, DOI 10.1016/j.diabres.2020.108072
   Wlodarska M, 2017, CELL HOST MICROBE, V22, P25, DOI 10.1016/j.chom.2017.06.007
   Wu H, 2020, CELL METAB, V32, P379, DOI 10.1016/j.cmet.2020.06.011
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Yaribeygi H, 2019, LIFE SCI, V234, DOI 10.1016/j.lfs.2019.116776
   Yu LL, 2019, MEDIAT INFLAMM, V2019, DOI 10.1155/2019/5271295
   Zeisel SH, 2017, ANNU REV NUTR, V37, P157, DOI 10.1146/annurev-nutr-071816-064732
   Zhang QQ, 2016, MEDICINA-LITHUANIA, V52, P28, DOI 10.1016/j.medici.2015.11.008
   Zhang XY, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0071108
   Zhao LP, 2018, SCIENCE, V359, P1151, DOI 10.1126/science.aao5774
NR 91
TC 6
Z9 7
U1 2
U2 22
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2304-8158
J9 FOODS
JI Foods
PD NOV
PY 2021
VL 10
IS 11
AR 2528
DI 10.3390/foods10112528
PG 20
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA XI0QR
UT WOS:000725828200001
PM 34828808
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Zhong, RT
   Chen, LB
   Liu, YY
   Xie, SX
   Li, SM
   Liu, B
   Zhao, C
AF Zhong, Ruting
   Chen, Lanbin
   Liu, Yuanyuan
   Xie, Shouxia
   Li, Sumei
   Liu, Bin
   Zhao, Chao
TI Anti-diabetic effect of aloin via JNK-IRS1/PI3K pathways and regulation
   of gut microbiota
SO FOOD SCIENCE AND HUMAN WELLNESS
LA English
DT Article
DE Aloin; Antidiabetic; Gut microbiota; Insulin signaling pathway
ID INSULIN-RESISTANCE; IN-VITRO; VERA GEL; HEPG2; ASSOCIATION; ANTIOXIDANT;
   METABOLISM; METFORMIN; OBESITY; GROWTH
AB This research aimed to investigate the antidiabetic activity, underlying mechanisms, and gut microbiota regulation of aloin. The insulin-resistant HepG2 (IR-HepG2) cell model and the type 2 diabetic (T2D) mouse model were successfully established using dexamethasone and a high-fat high-sucrose diet with low-dose streptozotocin, respectively. Aloin intervention increased glucose consumption and stimulated the activity of hexokinase and pyruvate dehydrogenase in IR-HepG2 cells. Additionally, it diminished the weight loss, reduced fasting blood glucose levels and hemoglobin A1c activity, and promoted glucose tolerance and fasting serum insulin activity in T2D mice. Histopathological analysis of the liver indicated hepatic protection by aloin. Additionally, aloin treatment inhibited the protein expression of c-Jun N-terminal kinases and activated that of IRS1/PI3K/Akt in the liver. Moreover, aloin modulated the bacterial community in the gut by raising the abundance of Bacteroidota and reducing the richness of Firmicutes, Proteobacteria, and Actinobacteriota. Thus, aloin ameliorated IR via activating IRS1/PI3K/Akt signaling pathway and regulating the gut microbiota, and it may be promising candidate as functional food for diabetic therapy. (C) 2021 Beijing Academy of Food Sciences. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.
C1 [Zhong, Ruting; Chen, Lanbin; Liu, Yuanyuan; Liu, Bin; Zhao, Chao] Fujian Agr & Forestry Univ, Coll Food Sci, Fuzhou 350002, Peoples R China.
   [Xie, Shouxia; Li, Sumei] Jinan Univ, Clin Med Coll 2, Shenzhen Peoples Hosp, Dept Pharmacol, Shenzhen 518020, Guangdong, Peoples R China.
   [Xie, Shouxia; Li, Sumei] Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen 518020, Guangdong, Peoples R China.
   [Liu, Bin; Zhao, Chao] Minist Educ, Engn Res Ctr Fujian Taiwan Special Marine Food Pr, Fuzhou 350002, Peoples R China.
C3 Fujian Agriculture & Forestry University; Jinan University; Southern
   University of Science & Technology
RP Zhao, C (通讯作者)，Fujian Agr & Forestry Univ, Coll Food Sci, Fuzhou 350002, Peoples R China.; Li, SM (通讯作者)，Jinan Univ, Clin Med Coll 2, Shenzhen Peoples Hosp, Dept Pharmacol, Shenzhen 518020, Guangdong, Peoples R China.; Li, SM (通讯作者)，Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen 518020, Guangdong, Peoples R China.; Zhao, C (通讯作者)，Minist Educ, Engn Res Ctr Fujian Taiwan Special Marine Food Pr, Fuzhou 350002, Peoples R China.
EM lism81@163.com; zhchao@live.cn
RI Zhao, Chao/P-1847-2017; liu, yuanyuan/IQS-2755-2023; liu,
   qi/IQR-4870-2023; liu, yuanyuan/HSG-8372-2023; liu,
   yuanyuan/GWZ-5838-2022; LI, XIAO/IQV-9318-2023; liu, xiao/HKE-9880-2023;
   liu, 园园/HJI-4438-2023
OI Zhao, Chao/0000-0003-1096-632X; 
FU Key Project of the Natural Science Foundation of Fujian Province
   [2020J02032]; Double First-Class Construction Plan of Fujian Agriculture
   and Forestry University [KSYLX013]; Shenzhen Key Medical Discipline
   Construction Fund [SZXK059]
FX This work was supported by Key Project of the Natural Science Foundation
   of Fujian Province (2020J02032), Double First-Class Construction Plan of
   Fujian Agriculture and Forestry University (KSYLX013), and Shenzhen Key
   Medical Discipline Construction Fund (SZXK059).
CR ALLERT S, 1991, EUR J BIOCHEM, V200, P19, DOI 10.1111/j.1432-1033.1991.tb21043.x
   Bao T, 2016, J ZHEJIANG UNIV-SC B, V17, P941, DOI 10.1631/jzus.B1600243
   Barcenilla A, 2000, APPL ENVIRON MICROB, V66, P1654, DOI 10.1128/AEM.66.4.1654-1661.2000
   Brandon EFA, 2006, TOXICOL APPL PHARM, V211, P1, DOI 10.1016/j.taap.2005.05.004
   Chaudhury A, 2017, FRONT ENDOCRINOL, V8, DOI 10.3389/fendo.2017.00006
   Chen YQ, 2019, FOOD CHEM TOXICOL, V126, P295, DOI 10.1016/j.fct.2019.02.034
   Chen YQ, 2018, CARBOHYD POLYM, V198, P452, DOI 10.1016/j.carbpol.2018.06.077
   Clemente JC, 2012, CELL, V148, P1258, DOI 10.1016/j.cell.2012.01.035
   Downes J, 2013, INT J SYST EVOL MICR, V63, P1214, DOI 10.1099/ijs.0.041376-0
   Favaretto F, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0109540
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Gowd V, 2019, TRENDS FOOD SCI TECH, V93, P81, DOI 10.1016/j.tifs.2019.09.005
   Gowd V, 2019, CRIT REV BIOTECHNOL, V39, P524, DOI 10.1080/07388551.2019.1576025
   Gowd V, 2018, FOOD CHEM, V269, P618, DOI 10.1016/j.foodchem.2018.07.020
   Gowd V, 2017, TRENDS FOOD SCI TECH, V68, P1, DOI 10.1016/j.tifs.2017.07.015
   Harazaki T, 2014, NUTRITION, V30, P590, DOI 10.1016/j.nut.2013.10.020
   Hirosumi J, 2002, NATURE, V420, P333, DOI 10.1038/nature01137
   Hostalek U, 2015, DRUGS, V75, P1071, DOI 10.1007/s40265-015-0416-8
   Hu RK, 2018, J FUNCT FOODS, V46, P403, DOI 10.1016/j.jff.2018.05.020
   Ismail NA, 2011, ARCH MED SCI, V7, P501, DOI 10.5114/aoms.2011.23418
   Kadowaki T, 2012, CELL, V148, P624, DOI 10.1016/j.cell.2012.01.034
   Karim N., 2018, WALAILAK J SCI TECHN, V16, P143, DOI [10.13140/RG.2.2.25576.93441, DOI 10.13140/RG.2.2.25576.93441]
   Karim N, 2020, J AM COLL NUTR, V39, P501, DOI 10.1080/07315724.2019.1696251
   Kelder T, 2014, NUTR DIABETES, V4, DOI 10.1038/nutd.2014.18
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   LeRoith D, 2006, INT J BIOCHEM CELL B, V38, P904, DOI 10.1016/j.biocel.2005.01.019
   Lin CL, 2008, MOL NUTR FOOD RES, V52, P930, DOI 10.1002/mnfr.200700437
   Lin CL, 2007, J LIPID RES, V48, P2334, DOI 10.1194/jlr.M700128-JLR200
   Lin GP, 2021, PHARMACOL RES, V165, DOI 10.1016/j.phrs.2021.105436
   Liu FW, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0143528
   Martinez I, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0069621
   MOSMANN T, 1983, J IMMUNOL METHODS, V65, P55, DOI 10.1016/0022-1759(83)90303-4
   Naderpoor N, 2019, J CLIN MED, V8, DOI 10.3390/jcm8040452
   Navab-Moghadam F, 2017, MICROB PATHOGENESIS, V110, P630, DOI 10.1016/j.micpath.2017.07.034
   Perez YY, 2007, AM J CHINESE MED, V35, P1037, DOI 10.1142/S0192415X07005491
   Plovier H, 2017, NAT MED, V23, P107, DOI 10.1038/nm.4236
   RODE LM, 1981, APPL ENVIRON MICROB, V42, P20, DOI 10.1128/AEM.42.1.20-22.1981
   Shang QS, 2016, MAR DRUGS, V14, DOI 10.3390/md14120224
   Shibayama A, 2016, J AM GERIATR SOC, V64, P1376, DOI 10.1111/jgs.14169
   Su HM, 2020, OXID MED CELL LONGEV, V2020, DOI 10.1155/2020/6538930
   Su HM, 2020, J FUNCT FOODS, V64, DOI 10.1016/j.jff.2019.103657
   Su HM, 2020, J AGR FOOD CHEM, V68, P13025, DOI 10.1021/acs.jafc.9b03338
   Sun HL, 2019, EUR J PHARMACOL, V859, DOI 10.1016/j.ejphar.2019.172526
   Sung KC, 2012, DIABETES CARE, V35, P717, DOI 10.2337/dc11-1853
   Tabatabaei SRF, 2017, BIOMED PHARMACOTHER, V96, P279, DOI 10.1016/j.biopha.2017.09.146
   Thiruppathi M, 2021, SENSOR ACTUAT B-CHEM, V329, DOI 10.1016/j.snb.2020.129119
   Tsai S, 2015, DIABETES, V64, P1886, DOI 10.2337/db14-1488
   Wamer WG, 2003, FREE RADICAL BIO MED, V34, P233, DOI 10.1016/S0891-5849(02)01242-X
   Wan XZ, 2020, J AGR FOOD CHEM, V68, P1186, DOI 10.1021/acs.jafc.9b06282
   Wan XZ, 2019, FOOD CHEM TOXICOL, V128, P233, DOI 10.1016/j.fct.2019.04.017
   Wu WL, 2011, MOL GENET METAB, V102, P374, DOI 10.1016/j.ymgme.2010.11.165
   Yan X, 2019, J FOOD SCI, V84, P165, DOI 10.1111/1750-3841.14415
   Yang CF, 2019, FOOD CHEM TOXICOL, V131, DOI 10.1016/j.fct.2019.110562
   Zhao C, 2019, CRIT REV FOOD SCI, V59, P830, DOI 10.1080/10408398.2018.1501658
   Zhao C, 2018, MOL NUTR FOOD RES, V62, DOI 10.1002/mnfr.201700730
   Zhao C, 2018, TRENDS FOOD SCI TECH, V72, P1, DOI 10.1016/j.tifs.2017.12.001
   Zhou WT, 2020, J FUNCT FOODS, V75, DOI 10.1016/j.jff.2020.104222
NR 57
TC 6
Z9 6
U1 15
U2 53
PU KEAI PUBLISHING LTD
PI BEIJING
PA 16 DONGHUANGCHENGGEN NORTH ST, BEIJING, DONGHENG DISTRICT 100717,
   PEOPLES R CHINA
EI 2213-4530
J9 FOOD SCI HUM WELL
JI Food Sci. Human Wellness
PD JAN
PY 2022
VL 11
IS 1
BP 189
EP 198
DI 10.1016/j.fshw.2021.07.019
PG 10
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA UP7BG
UT WOS:000695531000019
OA gold
DA 2023-06-08
ER

PT J
AU Lustig, RH
   Collier, D
   Kassotis, C
   Roepke, TA
   Kim, MJ
   Blanc, E
   Barouki, R
   Bansal, A
   Cave, MC
   Chatterjee, S
   Choudhury, M
   Gilbertson, M
   Lagadic-Gossmann, D
   Howard, S
   Lind, L
   Tomlinson, CR
   Vondracek, J
   Heindel, JJ
AF Lustig, Robert H.
   Collier, David
   Kassotis, Christopher
   Roepke, Troy A.
   Kim, Min Ji
   Blanc, Etienne
   Barouki, Robert
   Bansal, Amita
   Cave, Matthew C.
   Chatterjee, Saurabh
   Choudhury, Mahua
   Gilbertson, Michael
   Lagadic-Gossmann, Dominique
   Howard, Sarah
   Lind, Lars
   Tomlinson, Craig R.
   Vondracek, Jan
   Heindel, Jerrold J.
TI Obesity I: Overview and molecular and biochemical mechanisms
SO BIOCHEMICAL PHARMACOLOGY
LA English
DT Review
DE Obesity; Metabolism; Hormone receptors; Adipose tissue; Microbiome;
   Energy balance
ID FARNESOID-X-RECEPTOR; FATTY LIVER-DISEASE; MESENCHYMAL STEM-CELLS;
   BODY-MASS INDEX; NUTRITION EXAMINATION SURVEY; FLUTAMIDE-METFORMIN
   THERAPY; ADIPOSE-TISSUE INFLAMMATION; CARDIOVASCULAR RISK-FACTORS;
   DIET-INDUCED OBESITY; DEFICIENT ARKO MICE
AB Obesity is a chronic, relapsing condition characterized by excess body fat. Its prevalence has increased globally since the 1970s, and the number of obese and overweight people is now greater than those underweight. Obesity is a multifactorial condition, and as such, many components contribute to its development and pathogenesis. This is the first of three companion reviews that consider obesity. This review focuses on the genetics, viruses, insulin resistance, inflammation, gut microbiome, and circadian rhythms that promote obesity, along with hormones, growth factors, and organs and tissues that control its development. It shows that the regulation of energy balance (intake vs. expenditure) relies on the interplay of a variety of hormones from adipose tissue, gastrointestinal tract, pancreas, liver, and brain. It details how integrating central neurotransmitters and peripheral metabolic signals (e.g., leptin, insulin, ghrelin, peptide YY3-36) is essential for controlling energy homeostasis and feeding behavior. It describes the distinct types of adipocytes and how fat cell development is controlled by hormones and growth factors acting via a variety of receptors, including peroxisome proliferator-activated receptor-gamma, retinoid X, insulin, estrogen, androgen, glucocorticoid, thyroid hormone, liver X, constitutive androstane, pregnane X, farnesoid, and aryl hydrocarbon receptors. Finally, it demonstrates that obesity likely has origins in utero. Understanding these biochemical drivers of adiposity and metabolic dysfunction throughout the life cycle lends plausibility and credence to the "obesogen hypothesis " (i.e., the importance of environmental chemicals that disrupt these receptors to promote adiposity or alter metabolism), elucidated more fully in the two companion reviews.
C1 [Lustig, Robert H.] Univ Calif San Francisco, Dept Pediat, Div Endocrinol, San Francisco, CA 94143 USA.
   [Collier, David] East Carolina Univ, Brody Sch Med, Greenville, NC 27834 USA.
   [Kassotis, Christopher] Wayne State Univ, Inst Environm Hlth Sci, Dept Pharmacol, Detroit, MI 48202 USA.
   [Roepke, Troy A.] Rutgers State Univ, Sch Environm & Biol Sci, New Brunswick, NJ 08901 USA.
   [Kim, Min Ji] Sorbonne Paris Nord Univ, INSERM U1124 T3S, Bobigny, Paris, France.
   [Blanc, Etienne; Barouki, Robert] Univ Paris, Dept Biochem & Toxicol, INSERM U1224 T3S, F-75006 Paris, France.
   [Bansal, Amita] Australian Natl Univ, Coll Hlth & Med, Canberra, Australia.
   [Cave, Matthew C.] Univ Louisville, Div Gastroenterol Hepatol & Nutr, Louisville, KY 40402 USA.
   [Chatterjee, Saurabh] Univ South Carolina, Environm Hlth & Dis Lab, Columbia, SC 29208 USA.
   [Choudhury, Mahua] Texas A&M Univ, Coll Pharm, College Stn, TX 77843 USA.
   [Gilbertson, Michael] Univ Stirling, Occupat & Environm Hlth Res Grp, Stirling, Scotland.
   [Lagadic-Gossmann, Dominique] Univ Rennes, INSERM, EHESP, IRSET-UMR S 1085, F-35000 Rennes, France.
   [Howard, Sarah; Heindel, Jerrold J.] Hlth Environm & Endocrine Disruptor Strategies, Commonweal, Bolinas, CA 92924 USA.
   [Lind, Lars] Uppsala Univ, Dept Med Sci, Uppsala, Sweden.
   [Tomlinson, Craig R.] Norris Cotton Canc Ctr, Geisel Sch Med Dartmouth, Dept Mol & Syst Biol, Lebanon, NH 03756 USA.
   [Vondracek, Jan] Inst Biophys Czech Acad Sci, Dept Cytokinet, Brno, Czech Republic.
   [Heindel, Jerrold J.] HEEDS, Commonweal, 451 Mesa Rd, Bolinas, CA 92924 USA.
C3 University of California System; University of California San Francisco;
   University of North Carolina; East Carolina University; Wayne State
   University; Rutgers State University New Brunswick; UDICE-French
   Research Universities; Universite Paris Cite; UDICE-French Research
   Universities; Universite Paris Cite; Australian National University;
   University of Louisville; University of South Carolina System;
   University of South Carolina Columbia; Texas A&M University System;
   Texas A&M University College Station; University of Stirling; Ecole des
   Hautes Etudes en Sante Publique (EHESP); Institut National de la Sante
   et de la Recherche Medicale (Inserm); Universite de Rennes; Uppsala
   University; Dartmouth College; Norris Cotton Cancer Center
RP Heindel, JJ (通讯作者)，Hlth Environm & Endocrine Disruptor Strategies, Commonweal, Bolinas, CA 92924 USA.; Heindel, JJ (通讯作者)，HEEDS, Commonweal, 451 Mesa Rd, Bolinas, CA 92924 USA.
EM jerryheindel@gmail.com
RI kim, minji/GRX-9996-2022; Tomlinson, Craig R./F-1319-2017
OI Bansal, Amita/0000-0001-8716-9922; Kassotis,
   Christopher/0000-0002-0990-2428; CHATTERJEE,
   SAURABH/0000-0003-1649-7149; Howard, Sarah/0000-0001-8925-5517; kim, Min
   Ji/0000-0002-1403-9331
FU NIH [R00ES030405, R01MH12 3544, P30ES005022, R35ES028373, R01ES032189,
   T32ES011564, P42ES023716, P30ES030283, R21ES031510, P20GM103641,
   P01ES028942, P01AT003961, P30ES025128]; European Union [825712]; Swedish
   Research Council for Sustainable Development (FORMAS) [2019-00375];
   USDA/NIFA [NJ6195]; Czech Science Foundation [21-005335]; Institute of
   Biophysics of the Czech Academy of Science [RVO-68081707]; Diabetes
   Australia [S5610040]; Morris L Lichtenstein Jr Medical Research
   Foundation; DoD-IIRFA [W81XWH1810374]
FX Christopher Kassotis, NIH, R00ES030405.; Dominique Lagadic-Gossman,
   European Union Horizon 2020 Research and Innovation Program, Oberon
   #825712.; Vesna Munic Kos, Swedish Research Council for Sustainable
   Development (FORMAS) #2019-00375.; Troy Roepke, NIH, R01MH12 3544,
   P30ES005022, USDA/NIFA NJ6195.; Jan Vondracek, Czech Science Foundation
   #21-005335, Institute of Biophysics of the Czech Academy of Science,
   RVO-68081707.; Robert Barouki, European Union Horizon 2020 Research and
   Innovation Program, Oberon #825712.; Amita Bansal, Diabetes Australia
   #S5610040.; Mathew Cave, NIH, R35ES028373, R01ES032189, T32ES011564,
   P42ES023716, P30ES030283, R21ES031510.; Saurabh Chatterjee, NIH,
   P20GM103641, P01ES028942, P01AT003961, DoD-IIRFA W81XWH1810374.; Mahua
   Choudhury, Morris L Lichtenstein Jr Medical Research Foundation.; David
   Collier, NIH, P30ES025128.
CR Abbasi F, 2004, DIABETES, V53, P585, DOI 10.2337/diabetes.53.3.585
   Abdelkarim M, 2010, J BIOL CHEM, V285, P36759, DOI 10.1074/jbc.M110.166231
   Abenavoli L, 2019, NUTRIENTS, V11, DOI 10.3390/nu11112690
   Aguilar T, 2020, CHILD OBES, V16, P358, DOI 10.1089/chi.2019.0312
   Aguilera CM, 2013, NUTR HOSP, V28, P44, DOI 10.3305/nh.2013.28.sup5.6917
   Agus A, 2018, CELL HOST MICROBE, V23, P716, DOI 10.1016/j.chom.2018.05.003
   Allard C, 2015, EPIGENETICS-US, V10, P342, DOI 10.1080/15592294.2015.1029700
   Andolfi C, 2018, J LAPAROENDOSC ADV S, V28, P919, DOI 10.1089/lap.2018.0380
   Andriessen C, 2021, INT J OBESITY, V45, P479, DOI 10.1038/s41366-020-00719-9
   Araujo J, 2019, METAB SYNDR RELAT D, V17, P46, DOI 10.1089/met.2018.0105
   Archer A, 2013, J LIPID RES, V54, P1300, DOI 10.1194/jlr.M033977
   Arends NJT, 2005, CLIN ENDOCRINOL, V62, P44, DOI 10.1111/j.1365-2265.2004.02171.x
   Arner Peter, 2018, Nestle Nutr Inst Workshop Ser, V89, P37, DOI 10.1159/000486491
   Asada M, 2011, LAB INVEST, V91, P203, DOI 10.1038/labinvest.2010.170
   Atkinson RL, 2007, MAYO CLIN PROC, V82, P1192, DOI 10.4065/82.10.1192
   Atkinson RL, 2005, INT J OBESITY, V29, P281, DOI 10.1038/sj.ijo.0802830
   Baik JH, 2021, ENDOCRINOL METAB, V36, P229, DOI 10.3803/EnM.2021.979
   Baik JH, 2013, FRONT NEURAL CIRCUIT, V7, DOI 10.3389/fncir.2013.00152
   Bansal A, 2018, ENDOCRINOLOGY, V159, P32, DOI 10.1210/en.2017-00882
   Barbatelli G, 2010, AM J PHYSIOL-ENDOC M, V298, pE1244, DOI 10.1152/ajpendo.00600.2009
   Barber TM, 2021, INT J MOL SCI, V22
   Barker DJP, 2007, J INTERN MED, V261, P412, DOI 10.1111/j.1365-2796.2007.01809.x
   BARKER DJP, 1990, BRIT MED J, V301, P1111, DOI 10.1136/bmj.301.6761.1111
   Barouki R, 2018, ENVIRON INT, V114, P77, DOI 10.1016/j.envint.2018.02.014
   Bastien M, 2019, AM J PHYSIOL-ENDOC M, V317, pE65, DOI 10.1152/ajpendo.00505.2018
   Basu S, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0057873
   Beltrand J, 2020, FRONT PEDIATR, V8, DOI 10.3389/fped.2020.540718
   Benziger CP, 2016, GLOB HEART, V11, P393, DOI 10.1016/j.gheart.2016.10.024
   Bhattacharya J, 2009, J HEALTH ECON, V28, P649, DOI 10.1016/j.jhealeco.2009.02.009
   Birkenfeld AL, 2014, HEPATOLOGY, V59, P713, DOI 10.1002/hep.26672
   Bjornstad P, 2021, NEW ENGL J MED, V385, P416, DOI 10.1056/NEJMoa2100165
   BJORNTORP P, 1990, J INTERN MED, V227, P147
   Blaak E, 2001, CURR OPIN CLIN NUTR, V4, P499, DOI 10.1097/00075197-200111000-00006
   Bloom SL, 2001, OBSTET GYNECOL, V97, P485, DOI 10.1016/S0029-7844(00)01206-0
   Blouin K, 2008, J STEROID BIOCHEM, V108, P272, DOI 10.1016/j.jsbmb.2007.09.001
   Blouin K, 2010, CLIN ENDOCRINOL, V72, P176, DOI 10.1111/j.1365-2265.2009.03645.x
   Bluher M, 2020, ENDOCR REV, V41, P405, DOI 10.1210/endrev/bnaa004
   Bluher M, 2019, NAT REV ENDOCRINOL, V15, P288, DOI 10.1038/s41574-019-0176-8
   Boney CM, 2005, PEDIATRICS, V115, pE290, DOI 10.1542/peds.2004-1808
   Boucher J, 2016, DIABETES, V65, P2201, DOI 10.2337/db16-0212
   Bouret SG, 2004, ENDOCRINOLOGY, V145, P2621, DOI 10.1210/en.2004-0231
   Boursier J, 2016, HEPATOLOGY, V63, P764, DOI 10.1002/hep.28356
   Boyle KE, 2017, MOL METAB, V6, P1503, DOI 10.1016/j.molmet.2017.08.012
   BRATUSCHMARRAIN P, 1978, HORM METAB RES, V10, P412, DOI 10.1055/s-0028-1093403
   Braun JM, 2016, OBESITY, V24, P231, DOI 10.1002/oby.21258
   Bremer AA, 2011, J CLIN ENDOCR METAB, V96, pE1782, DOI 10.1210/jc.2011-1577
   Brestoff JR, 2015, CELL, V161, P146, DOI 10.1016/j.cell.2015.02.022
   Britton KA, 2011, CIRCULATION, V124, pE837, DOI 10.1161/CIRCULATIONAHA.111.077602
   Brun RP, 1996, GENE DEV, V10, P974, DOI 10.1101/gad.10.8.974
   Bryzgalova G, 2008, J STEROID BIOCHEM, V111, P262, DOI 10.1016/j.jsbmb.2008.06.010
   Calle EE, 1999, NEW ENGL J MED, V341, P1097, DOI 10.1056/NEJM199910073411501
   Cani PD, 2018, GUT, V67, P1716, DOI 10.1136/gutjnl-2018-316723
   Cao WH, 2004, MOL CELL BIOL, V24, P3057, DOI 10.1128/MCB.24.7.3057-3067.2004
   Cariou B, 2006, J BIOL CHEM, V281, P11039, DOI 10.1074/jbc.M510258200
   Carobbio S, 2021, STEM CELL REP, V16, P641, DOI 10.1016/j.stemcr.2021.01.013
   Carpentier AC, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00447
   CARTER JK, 1983, INFECT IMMUN, V39, P410, DOI 10.1128/IAI.39.1.410-422.1983
   Castaner O, 2018, INT J ENDOCRINOL, V2018, DOI 10.1155/2018/4095789
   CATALANO PM, 1995, AM J OBSTET GYNECOL, V172, P1464, DOI 10.1016/0002-9378(95)90479-4
   Chan JCN, 2002, INT J OBESITY, V26, P994, DOI 10.1038/sj.ijo.0802017
   CHAN JM, 1994, DIABETES CARE, V17, P961, DOI 10.2337/diacare.17.9.961
   Charbogne P, 2017, BIOL PSYCHIAT, V81, P778, DOI 10.1016/j.biopsych.2016.12.022
   CHAWLA A, 1994, ENDOCRINOLOGY, V135, P798, DOI 10.1210/en.135.2.798
   Chazenbalk G, 2013, STEROIDS, V78, P920, DOI 10.1016/j.steroids.2013.05.001
   Chehab FF, 2008, ENDOCRINOLOGY, V149, P925, DOI 10.1210/en.2007-1355
   Chen DL, 2015, J CLIN ENDOCR METAB, V100, P4082, DOI 10.1210/jc.2015-2712
   Chen Y, 2019, NATURE, V565, P180, DOI 10.1038/s41586-018-0801-z
   Cildir G, 2013, TRENDS MOL MED, V19, P487, DOI 10.1016/j.molmed.2013.05.001
   Cinti S, 2018, TRENDS ENDOCRIN MET, V29, P651, DOI 10.1016/j.tem.2018.05.007
   Contador D, 2015, EXP BIOL MED, V240, P1235, DOI 10.1177/1535370214566565
   Cooke PS, 2004, EXP BIOL MED, V229, P1127, DOI 10.1177/153537020422901107
   Crewe C, 2017, J CLIN INVEST, V127, P74, DOI 10.1172/JCI88883
   Crocker MK, 2014, J CLIN ENDOCR METAB, V99, pE1519, DOI 10.1210/jc.2014-1384
   Curhan GC, 1996, CIRCULATION, V94, P1310, DOI 10.1161/01.CIR.94.6.1310
   Curhan GC, 1996, CIRCULATION, V94, P3246, DOI 10.1161/01.CIR.94.12.3246
   Cypess AM, 2012, P NATL ACAD SCI USA, V109, P10001, DOI 10.1073/pnas.1207911109
   D'Adamo E, 2010, DIABETES CARE, V33, P1817, DOI 10.2337/dc10-0284
   Dahlman I, 2006, PHARMACOGENET GENOM, V16, P881, DOI 10.1097/01.fpc.0000236334.49422.48
   Dale J, 2001, CLIN ENDOCRINOL, V55, P233, DOI 10.1046/j.1365-2265.2001.01329.x
   Dallman MF, 2005, BRAIN BEHAV IMMUN, V19, P275, DOI 10.1016/j.bbi.2004.11.004
   Dallman MF, 2003, P NATL ACAD SCI USA, V100, P11696, DOI 10.1073/pnas.1934666100
   DARIMONT C, 1993, MOL CELL ENDOCRINOL, V98, P67, DOI 10.1016/0303-7207(93)90238-F
   Das M, 2015, FRONT GENET, V6, DOI 10.3389/fgene.2015.00304
   Davis SR, 2012, CLIMACTERIC, V15, P419, DOI 10.3109/13697137.2012.707385
   de Almeida DC, 2017, WORLD J STEM CELLS, V9, P152, DOI 10.4252/wjsc.v9.i9.152
   de Vegt F, 1999, DIABETOLOGIA, V42, P926, DOI 10.1007/s001250051249
   der Weij JD, 2009, ENDOCRINOLOGY, V150, P2368, DOI 10.1210/en.2008-1540
   DEMPSTER P, 1995, MED SCI SPORT EXER, V27, P1692
   Derby CA, 2009, AM J EPIDEMIOL, V169, P1352, DOI 10.1093/aje/kwp043
   Desai MS, 2016, CELL, V167, P1339, DOI 10.1016/j.cell.2016.10.043
   Diamanti-Kandarakis E, 1998, J CLIN ENDOCR METAB, V83, P2699, DOI 10.1210/jc.83.8.2699
   Dieudonne MN, 2000, ENDOCRINOLOGY, V141, P649, DOI 10.1210/en.141.2.649
   Dobner J, 2018, CLIN MICROBIOL INFEC, V24, P24, DOI 10.1016/j.cmi.2017.02.013
   Durack J, 2019, J EXP MED, V216, P20, DOI 10.1084/jem.20180448
   Ehtesham N, 2021, MOL BIOL REP, V48, P2817, DOI 10.1007/s11033-021-06275-3
   Emilsson V, 2000, METABOLISM, V49, P1610, DOI 10.1053/meta.2000.18692
   Entringer S, 2008, AM J OBSTET GYNECOL, V199, DOI 10.1016/j.ajog.2008.03.006
   Fagman JB, 2015, FASEB J, V29, P1540, DOI 10.1096/fj.14-259234
   Fan WQ, 2005, DIABETES, V54, P1000, DOI 10.2337/diabetes.54.4.1000
   Fan ZQ, 2020, ADV EXP MED BIOL, V1228, P63, DOI 10.1007/978-981-15-1792-1_4
   Fandriks L, 2017, J INTERN MED, V281, P319, DOI 10.1111/joim.12584
   Farmer SR, 2006, CELL METAB, V4, P263, DOI 10.1016/j.cmet.2006.07.001
   Farol Len T, 2004, Expert Rev Anticancer Ther, V4, P180, DOI 10.1586/14737140.4.2.180
   Farooqi IS, 2007, SCIENCE, V317, P1355, DOI 10.1126/science.1144599
   Fazakerley DJ, 2019, J LIPID RES, V60, P1720, DOI 10.1194/jlr.R087510
   Feldman BJ, 2006, P NATL ACAD SCI USA, V103, P15675, DOI 10.1073/pnas.0607501103
   Feldman BJ, 2009, PEDIATR RES, V65, P249, DOI 10.1203/PDR.0b013e3181989667
   Ferrarese R, 2018, EUR REV MED PHARMACO, V22, P7588, DOI 10.26355/eurrev_201811_16301
   Figlewicz DP, 2003, BRAIN RES, V964, P107, DOI 10.1016/S0006-8993(02)04087-8
   Forcheron F, 2002, DIABETES, V51, P3486, DOI 10.2337/diabetes.51.12.3486
   FOSTERPOWELL K, 1995, AM J CLIN NUTR, V62, p871S, DOI 10.1093/ajcn/62.4.871S
   FRANTZ ID, 1989, ARTERIOSCLEROSIS, V9, P129, DOI 10.1161/01.ATV.9.1.129
   French NP, 1999, AM J OBSTET GYNECOL, V180, P114, DOI 10.1016/S0002-9378(99)70160-2
   Fu SN, 2012, CELL METAB, V15, P623, DOI 10.1016/j.cmet.2012.03.007
   Fuentes N, 2019, ADV PROTEIN CHEM STR, V116, P135, DOI 10.1016/bs.apcsb.2019.01.001
   Funcke JB, 2019, J LIPID RES, V60, P1648, DOI 10.1194/jlr.R094060
   Gallagher EJ, 2015, PHYSIOL REV, V95, P727, DOI 10.1152/physrev.00030.2014
   Gao J, 2012, TRENDS PHARMACOL SCI, V33, P552, DOI 10.1016/j.tips.2012.07.003
   Gao J, 2009, J BIOL CHEM, V284, P25984, DOI 10.1074/jbc.M109.016808
   Geer EB, 2012, J CLIN ENDOCR METAB, V97, P1702, DOI 10.1210/jc.2011-3123
   Gerin I, 2005, J BIOL CHEM, V280, P23024, DOI 10.1074/jbc.M412564200
   Girer NG, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20040950
   Gonzalez-Gil AM, 2020, NUTRIENTS, V12, DOI 10.3390/nu12061899
   Gooley JJ, 2016, P NUTR SOC, V75, P440, DOI 10.1017/S0029665116000288
   Goossens GH, 2017, OBESITY FACTS, V10, P207, DOI 10.1159/000471488
   Goran MI, 2013, NAT REV ENDOCRINOL, V9, P494, DOI 10.1038/nrendo.2013.108
   Grover GJ, 2007, CURR VASC PHARMACOL, V5, P141, DOI 10.2174/157016107780368271
   Gruzdeva OV, 2018, TERAPEVT ARKH, V90, P71, DOI [10.26442/terarkh2018901071-78, 10.26442/terarkh201890104-78]
   Guan DY, 2021, J CLIN INVEST, V131, DOI 10.1172/JCI148278
   Guerre-Millo M, 2000, J BIOL CHEM, V275, P16638, DOI 10.1074/jbc.275.22.16638
   Guilherme A, 2020, CELL REP, V31, DOI 10.1016/j.celrep.2020.107598
   Gupta V, 2008, MOL CELL ENDOCRINOL, V296, P32, DOI 10.1016/j.mce.2008.08.019
   HALES CN, 1991, BMJ-BRIT MED J, V303, P1019, DOI 10.1136/bmj.303.6809.1019
   Hales Craig M, 2017, NCHS Data Brief, P1
   Halldorsson TI, 2012, ENVIRON HEALTH PERSP, V120, P668, DOI 10.1289/ehp.1104034
   Harris JE, 2018, TRENDS ENDOCRIN MET, V29, P164, DOI 10.1016/j.tem.2018.01.003
   He JH, 2013, DIABETES, V62, P1876, DOI 10.2337/db12-1039
   Heeren J, 2013, ENDOCRIN METAB CLIN, V42, P89, DOI 10.1016/j.ecl.2012.11.004
   Heerwagen MJR, 2010, AM J PHYSIOL-REG I, V299, pR711, DOI 10.1152/ajpregu.00310.2010
   Heindel JJ, 2009, MOL CELL ENDOCRINOL, V304, P90, DOI 10.1016/j.mce.2009.02.025
   Heine PA, 2000, P NATL ACAD SCI USA, V97, P12729, DOI 10.1073/pnas.97.23.12729
   Heinonen S, 2020, OBES REV, V21, DOI 10.1111/obr.12958
   Heisler LK, 2017, CURR OPIN PHARMACOL, V37, P100, DOI 10.1016/j.coph.2017.09.002
   Henao-Mejia J, 2012, NATURE, V482, P179, DOI 10.1038/nature10809
   Henderson CJ, 2015, BIOCHEM J, V465, P479, DOI 10.1042/BJ20140582
   Hill JO, 2006, ENDOCR REV, V27, P750, DOI 10.1210/er.2006-0032
   Hill JW, 2008, J CLIN INVEST, V118, P1796, DOI 10.1172/JCI32964
   Hofman PL, 2004, NEW ENGL J MED, V351, P2179, DOI 10.1056/NEJMoa042275
   Homan EP, 2021, J CLIN INVEST, V131, DOI 10.1172/JCI143328
   Hong L, 2006, TISSUE ENG, V12, P2747, DOI 10.1089/ten.2006.12.2747
   Howard BV, 2006, JAMA-J AM MED ASSOC, V295, P39, DOI 10.1001/jama.295.1.39
   Howard BV, 2006, JAMA-J AM MED ASSOC, V295, P655, DOI 10.1001/jama.295.6.655
   Hruby A, 2015, PHARMACOECONOMICS, V33, P673, DOI 10.1007/s40273-014-0243-x
   Ibanez L, 2003, J CLIN ENDOCR METAB, V88, P4720, DOI 10.1210/jc.2003-030117
   Ibanez L, 2003, J CLIN ENDOCR METAB, V88, P2600, DOI 10.1210/jc.2002-022002
   Ibanez L, 2006, J CLIN ENDOCR METAB, V91, P2153, DOI 10.1210/jc.2005-2778
   Ibrahim MM, 2010, OBES REV, V11, P11, DOI 10.1111/j.1467-789X.2009.00623.x
   Imai T, 2001, P NATL ACAD SCI USA, V98, P224, DOI 10.1073/pnas.011528898
   Imika M., 2020, BIOMOLECULES, V10
   Caria ACI, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19113608
   Isserow JA, 1999, AM J ROENTGENOL, V173, P1263, DOI 10.2214/ajr.173.5.10541101
   Itoh M, 2011, INT J INFLAMM, V2011, DOI 10.4061/2011/720926
   Iwen KA, 2013, EUR THYROID J, V2, P83, DOI 10.1159/000351249
   Jaacks LM, 2019, LANCET DIABETES ENDO, V7, P231, DOI 10.1016/S2213-8587(19)30026-9
   Jasik CB, 2008, ANN NY ACAD SCI, V1135, P265, DOI 10.1196/annals.1429.009
   Jastreboff AM, 2019, OBESITY, V27, P7, DOI 10.1002/oby.22378
   Jeong S, 2009, EXP MOL MED, V41, P397, DOI 10.3858/emm.2009.41.6.045
   Jiang W, 2004, J ENDOCRINOL, V182, P295, DOI 10.1677/joe.0.1820295
   Jiao Y, 2015, ACTA PHARMACOL SIN, V36, P44, DOI 10.1038/aps.2014.116
   John K, 2016, AM J PHYSIOL-ENDOC M, V310, pE249, DOI 10.1152/ajpendo.00478.2015
   Johnston CS, 2002, J AM COLL NUTR, V21, P55, DOI 10.1080/07315724.2002.10719194
   Jones MEE, 2000, P NATL ACAD SCI USA, V97, P12735, DOI 10.1073/pnas.97.23.12735
   Jones MEE, 2001, J STEROID BIOCHEM, V79, P3, DOI 10.1016/S0960-0760(01)00136-4
   Juvet LK, 2003, MOL ENDOCRINOL, V17, P172, DOI 10.1210/me.2001-0210
   Kabir M, 2005, AM J PHYSIOL-ENDOC M, V288, pE454, DOI 10.1152/ajpendo.00203.2004
   Kalaany NY, 2005, CELL METAB, V1, P231, DOI 10.1016/j.cmet.2005.03.001
   KANNEL WB, 1976, ANN INTERN MED, V85, P447, DOI 10.7326/0003-4819-85-4-447
   Kassotis CD, 2017, SCI REP-UK, V7, DOI 10.1038/srep42104
   Kershaw EE, 2005, DIABETES, V54, P1023, DOI 10.2337/diabetes.54.4.1023
   Kessler RM, 2016, NEUROSCI BIOBEHAV R, V63, P223, DOI 10.1016/j.neubiorev.2016.01.013
   Kim JY, 2020, ANN PEDIATR ENDOCRIN, V25, P208, DOI 10.6065/apem.2040140.070
   Kirchgessner TG, 2016, CELL METAB, V24, P223, DOI 10.1016/j.cmet.2016.07.016
   Kitamura T, 2003, ANNU REV PHYSIOL, V65, P313, DOI 10.1146/annurev.physiol.65.092101.142540
   Kleinridders A, 2014, DIABETES, V63, P2232, DOI 10.2337/db14-0568
   Klimentidis YC, 2011, P ROY SOC B-BIOL SCI, V278, P1626, DOI 10.1098/rspb.2010.1890
   Koch SSC, 1999, J MED CHEM, V42, P742, DOI 10.1021/jm980621r
   Kohsaka A, 2007, TRENDS ENDOCRIN MET, V18, P4, DOI 10.1016/j.tem.2006.11.005
   Kolb R, 2016, CURR OPIN PHARMACOL, V29, P77, DOI 10.1016/j.coph.2016.07.005
   Koliaki C, 2020, CURR OBES REP, V9, P255, DOI 10.1007/s13679-020-00396-9
   Kolyvanos Naumann U, 2007, Praxis (Bern 1994), V96, P1411, DOI 10.1024/1661-8157.96.38.1411
   Korach-Andre M, 2011, P NATL ACAD SCI USA, V108, P403, DOI 10.1073/pnas.1017884108
   Korakas E, 2020, AM J PHYSIOL-ENDOC M, V319, pE105, DOI 10.1152/ajpendo.00198.2020
   Koroukian SM, 2019, JAMA NETW OPEN, V2, DOI 10.1001/jamanetworkopen.2019.9261
   Kral JG, 2006, PEDIATRICS, V118, pE1644, DOI 10.1542/peds.2006-1379
   Landsberg L, 2013, J CLIN HYPERTENS, V15, P14, DOI 10.1111/jch.12049
   Laurans L, 2018, NAT MED, V24, P1113, DOI 10.1038/s41591-018-0060-4
   Laurens C, 2020, FRONT PHYSIOL, V11, DOI 10.3389/fphys.2020.00091
   Lawlor DA, 2007, AM J EPIDEMIOL, V165, P418, DOI 10.1093/aje/kwk030
   Lawrence JM, 2021, JAMA-J AM MED ASSOC, V326, P717, DOI 10.1001/jama.2021.11165
   Lee EH, 2021, PEDIATR OBES, V16, DOI 10.1111/ijpo.12793
   Lee MJ, 2014, INT J OBESITY, V38, P1228, DOI 10.1038/ijo.2014.6
   LEHMANN JM, 1995, J BIOL CHEM, V270, P12953, DOI 10.1074/jbc.270.22.12953
   Lehrke M, 2005, GENE DEV, V19, P1737, DOI 10.1101/gad.1341005
   LEWIS GF, 1993, DIABETES, V42, P833, DOI 10.2337/diabetes.42.6.833
   Lewis GF, 2002, ENDOCR REV, V23, P201, DOI 10.1210/er.23.2.201
   Ley RE, 2006, NATURE, V444, P1022, DOI 10.1038/4441022a
   Li H, 2021, LIFE SCI, V273, DOI 10.1016/j.lfs.2021.119314
   Li M, 2018, EUR J PHARMACOL, V831, P52, DOI 10.1016/j.ejphar.2018.05.003
   Li YJ, 2020, LIPIDS HEALTH DIS, V19, DOI 10.1186/s12944-020-01342-3
   Lin XY, 2004, J CLIN INVEST, V114, P908, DOI 10.1172/JCI22217
   Liu YY, 2003, J BIOL CHEM, V278, P38913, DOI 10.1074/jbc.M306120200
   Lobo Sandra, 2007, Novartis Found Symp, V286, P113
   Lonn L, 1998, J CLIN ENDOCR METAB, V83, P4269, DOI 10.1210/jc.83.12.4269
   Loomis AK, 2016, J CLIN ENDOCR METAB, V101, P945, DOI 10.1210/jc.2015-3444
   Los HS., 2021, INT J EMRIRAN RES PU, V18
   Lu CX, 2010, J MOL ENDOCRINOL, V44, P143, DOI 10.1677/JME-09-0107
   Lu Y, 2014, GUT, V63, P170, DOI 10.1136/gutjnl-2012-303150
   Ludwig D.S., 2021, AM J CLIN NUTR
   Ludwig DS, 2018, BMJ-BRIT MED J, V361, DOI 10.1136/bmj.k2340
   Lusis AJ, 2008, NAT REV GENET, V9, P819, DOI 10.1038/nrg2468
   Lustig RH, 2004, INT J OBESITY, V28, P1344, DOI 10.1038/sj.ijo.0802753
   Lustig RH, 2006, NAT CLIN PRACT ENDOC, V2, P447, DOI 10.1038/ncpendmet0220
   Lustig RH, 2016, OBESITY, V24, P453, DOI 10.1002/oby.21371
   Lutter M, 2009, J NUTR, V139, P629, DOI 10.3945/jn.108.097618
   Lynes MD, 2018, ANN NY ACAD SCI, V1411, P5, DOI 10.1111/nyas.13398
   LYONS MJ, 1982, SCIENCE, V216, P82, DOI 10.1126/science.7038878
   Magkos F, 2020, NAT REV ENDOCRINOL, V16, P545, DOI 10.1038/s41574-020-0381-5
   Makris MC, 2017, IN VIVO, V31, P1047, DOI 10.21873/invivo.11168
   Mammi C, 2012, INT J ENDOCRINOL, V2012, DOI 10.1155/2012/789653
   Maneschi E, 2013, J ENDOCRINOL, V218, P215, DOI 10.1530/JOE-13-0109
   Masuzaki H, 2001, SCIENCE, V294, P2166, DOI 10.1126/science.1066285
   Matafome P, 2017, ADV NEUROBIOL, V19, P33, DOI 10.1007/978-3-319-63260-5_2
   Mathieu P, 2010, CLIN PHARMACOL THER, V87, P407, DOI 10.1038/clpt.2009.311
   Matsumoto M, 2006, J CLIN INVEST, V116, P2464, DOI 10.1172/JCI27047
   Mayeuf-Louchart A, 2017, BIOCHIMIE, V143, P42, DOI 10.1016/j.biochi.2017.07.017
   McCarthy SF, 2020, AM J PHYSIOL-ENDOC M, V319, pE814, DOI 10.1152/ajpendo.00256.2020
   McIntosh BE, 2010, ANNU REV PHYSIOL, V72, P625, DOI 10.1146/annurev-physiol-021909-135922
   McLaughlin T, 2003, ANN INTERN MED, V139, P802, DOI 10.7326/0003-4819-139-10-200311180-00007
   Mechanick JI, 2012, ENDOCR PRACT, V18, P642, DOI 10.4158/EP12160.PS
   Mietus-Snyder ML, 2008, ANNU REV MED, V59, P147, DOI 10.1146/annurev.med.59.103106.105628
   Mohammed BS, 2008, OBESITY, V16, P2648, DOI 10.1038/oby.2008.418
   Camacho WJM, 2019, DIABETES-METAB RES, V35, DOI 10.1002/dmrr.3203
   Moreau A, 2008, MOL PHARM, V5, P35, DOI 10.1021/mp700103m
   Morton GJ, 2014, NAT REV NEUROSCI, V15, P367, DOI 10.1038/nrn3745
   Moseti D, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17010124
   Mukherjee R, 1997, NATURE, V386, P407, DOI 10.1038/386407a0
   Mukherji A, 2019, J HEPATOL, V71, P200, DOI 10.1016/j.jhep.2019.03.020
   Munzberg H, 2005, NAT NEUROSCI, V8, P566, DOI 10.1038/nn1454
   Murata Y, 2002, MOL CELL ENDOCRINOL, V193, P7, DOI 10.1016/S0303-7207(02)00090-4
   Nadal A, 2000, P NATL ACAD SCI USA, V97, P11603, DOI 10.1073/pnas.97.21.11603
   Naghavi M, 2017, LANCET LOND ENGL, V390, P1151, DOI [10.1016/S0140-6736(17)32152, 10.1016/S0140-6736(17)32152-9]
   Naimi M, 2007, ENDOCRINOLOGY, V148, P2424, DOI 10.1210/en.2006-1411
   Ng M, 2014, LANCET, V384, P766, DOI 10.1016/S0140-6736(14)60460-8
   Nguyen P, 2008, J ANIM PHYSIOL AN N, V92, P272, DOI 10.1111/j.1439-0396.2007.00752.x
   Nielsen R, 2008, GENE DEV, V22, P2953, DOI 10.1101/gad.501108
   O'Reilly MW, 2014, J STEROID BIOCHEM, V143, P277, DOI 10.1016/j.jsbmb.2014.04.008
   Oberlander TF, 2008, EPIGENETICS-US, V3, P97, DOI 10.4161/epi.3.2.6034
   Obregon MJ, 2008, THYROID, V18, P185, DOI 10.1089/thy.2007.0254
   Ogden Cynthia L, 2015, NCHS Data Brief, P1
   Oguri Y, 2020, CELL, V182, P563, DOI 10.1016/j.cell.2020.06.021
   Ohlsson C, 2000, BIOCHEM BIOPH RES CO, V278, P640, DOI 10.1006/bbrc.2000.3827
   Oken E, 2008, INT J OBESITY, V32, P201, DOI 10.1038/sj.ijo.0803760
   Oken E, 2003, OBES RES, V11, P496, DOI 10.1038/oby.2003.69
   Oliver WR, 2001, P NATL ACAD SCI USA, V98, P5306, DOI 10.1073/pnas.091021198
   Ong KKL, 2000, BRIT MED J, V320, P967, DOI 10.1136/bmj.320.7240.967
   Osborn O, 2012, NAT MED, V18, P363, DOI 10.1038/nm.2627
   Ouchi N, 2011, NAT REV IMMUNOL, V11, P85, DOI 10.1038/nri2921
   Pan XY, 2020, ADV EXP MED BIOL, V1276, P53, DOI 10.1007/978-981-15-6082-8_5
   Pantoja C, 2008, MOL BIOL CELL, V19, P4032, DOI 10.1091/mbc.E08-04-0420
   Park YW, 2003, ARCH INTERN MED, V163, P427, DOI 10.1001/archinte.163.4.427
   Parkar SG, 2019, MICROORGANISMS, V7, DOI 10.3390/microorganisms7020041
   Pasquali R, 2006, FERTIL STERIL, V85, P1319, DOI 10.1016/j.fertnstert.2005.10.054
   Pelletier P, 2008, ENDOCRINOLOGY, V149, P6471, DOI 10.1210/en.2008-0718
   Peters JM, 2000, MOL CELL BIOL, V20, P5119, DOI 10.1128/MCB.20.14.5119-5128.2000
   Petry CJ, 2000, HORM METAB RES, V32, P233, DOI 10.1055/s-2007-978627
   Pickering RT, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0167337
   Pilkington AC, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.599134
   Pinaire JA, 2007, PPAR RES, V2007, DOI 10.1155/2007/94156
   Pinney SE, 2012, CURR DIABETES REP, V12, P67, DOI 10.1007/s11892-011-0248-1
   Pinto S, 2004, SCIENCE, V304, P110, DOI 10.1126/science.1089459
   Plamper M, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19051268
   Ponterio E, 2015, VIRUSES-BASEL, V7, P3719, DOI 10.3390/v7072787
   Popkin BM, 2020, OBES REV, V21, DOI 10.1111/obr.13128
   Porter SA, 2009, DIABETES CARE, V32, P1068, DOI 10.2337/dc08-2280
   Prawitt J., 2009, DRUG DISCOV TODAY DI, V6, pe55 e64
   Prawitt J, 2011, DIABETES, V60, P1861, DOI 10.2337/db11-0030
   Qian SW, 2021, J BIOL CHEM, V296, DOI 10.1016/j.jbc.2021.100678
   Qin JJ, 2010, NATURE, V464, P59, DOI 10.1038/nature08821
   Rader DJ, 2007, AM J CARDIOL, V100, p15N, DOI 10.1016/j.amjcard.2007.08.008
   Ramsden CE, 2016, BMJ-BRIT MED J, V353, DOI 10.1136/bmj.i1246
   Ravussin E, 2002, ANN NY ACAD SCI, V967, P363
   Reilly SM, 2017, NAT REV ENDOCRINOL, V13, P633, DOI 10.1038/nrendo.2017.90
   Ren-Neto J., 2020, INT J MOL SCI, V21
   Ridaura VK, 2013, SCIENCE, V341, P1079, DOI 10.1126/science.1241214
   Rizzo G, 2006, MOL PHARMACOL, V70, P1164, DOI 10.1124/mol.106.023820
   Rogers I, 2003, INT J OBESITY, V27, P755, DOI 10.1038/sj.ijo.0802316
   RONCARI DAK, 1978, J CLIN INVEST, V62, P503, DOI 10.1172/JCI109153
   Roseboom TJ, 2001, MOL CELL ENDOCRINOL, V185, P93, DOI 10.1016/S0303-7207(01)00721-3
   Rosen ED, 1999, MOL CELL, V4, P611, DOI 10.1016/S1097-2765(00)80211-7
   Rosenbaum M, 2002, J CLIN ENDOCR METAB, V87, P2391, DOI 10.1210/jc.87.5.2391
   ROSENBLOOM AL, 1990, NEW ENGL J MED, V323, P1367, DOI 10.1056/NEJM199011153232002
   Rossi MA, 2018, CELL METAB, V27, P42, DOI 10.1016/j.cmet.2017.09.021
   Russo L, 2018, IMMUNOLOGY, V155, P407, DOI 10.1111/imm.13002
   Sadasivuni MK, 2014, DIABETOL METAB SYNDR, V6, DOI 10.1186/1758-5996-6-83
   Saltiel AR, 2017, J CLIN INVEST, V127, P1, DOI [10.1172/JCI92035, 10.1172/jci92035]
   Samocha-Bonet D, 2014, OBES REV, V15, P697, DOI 10.1111/obr.12199
   Sanchez-De la Torre Y, 2018, HORM MOL BIOL CLIN I, V33, DOI 10.1515/hmbci-2017-0076
   Sanna S, 2019, NAT GENET, V51, P600, DOI 10.1038/s41588-019-0350-x
   Sapunar J, 2020, INT J OBESITY, V44, P159, DOI 10.1038/s41366-019-0321-4
   Saran AR, 2020, GASTROENTEROLOGY, V158, P1948, DOI 10.1053/j.gastro.2020.01.050
   Sargis RM, 2010, OBESITY, V18, P1283, DOI 10.1038/oby.2009.419
   Sarwar R, 2018, DIABET METAB SYND OB, V11, P533, DOI 10.2147/DMSO.S146339
   Sato T, 2003, BIOCHEM BIOPH RES CO, V300, P167, DOI 10.1016/S0006-291X(02)02774-2
   Schwartz MW, 2017, ENDOCR REV, V38, P267, DOI 10.1210/er.2017-00111
   Schwarz JM, 2017, GASTROENTEROLOGY, V153, P743, DOI 10.1053/j.gastro.2017.05.043
   Seale P, 2008, NATURE, V454, P961, DOI 10.1038/nature07182
   Sekikawa A, 2010, J INTERF CYTOK RES, V30, P541, DOI 10.1089/jir.2009.0114
   Sell H, 2012, NAT REV ENDOCRINOL, V8, P709, DOI 10.1038/nrendo.2012.114
   Seo JB, 2004, MOL CELL BIOL, V24, P3430, DOI 10.1128/MCB.24.8.3430-3444.2004
   Sepulveda J, 2014, SCIENCE, V345, P1275, DOI 10.1126/science.1257099
   Serin Y, 2019, ANN NUTR METAB, V74, P322, DOI 10.1159/000500071
   Shang QL, 2014, OBESITY, V22, P895, DOI 10.1002/oby.20533
   Shimizu Y, 2000, P NATL ACAD SCI USA, V97, P779, DOI 10.1073/pnas.97.2.779
   Shoelson SE, 2006, J CLIN INVEST, V116, P1793, DOI 10.1172/JCI29069
   Shoucri BM, 2018, ENDOCRINOLOGY, V159, P2863, DOI 10.1210/en.2018-00056
   Shoucri BM, 2017, ENDOCRINOLOGY, V158, P3109, DOI 10.1210/en.2017-00348
   Shreiner AB, 2015, CURR OPIN GASTROEN, V31, P69, DOI 10.1097/MOG.0000000000000139
   Shulman AI, 2005, NEW ENGL J MED, V353, P604, DOI 10.1056/NEJMra043590
   Sidossis L, 2015, J CLIN INVEST, V125, P478, DOI 10.1172/JCI78362
   Silverman BL, 1998, DIABETES CARE, V21, pB142
   SILVERMAN BL, 1993, ANN NY ACAD SCI, V699, P36, DOI 10.1111/j.1749-6632.1993.tb18835.x
   Simmons RA, 2001, DIABETES, V50, P2279, DOI 10.2337/diabetes.50.10.2279
   Singh R, 2003, ENDOCRINOLOGY, V144, P5081, DOI 10.1210/en.2003-0741
   SLABBER M, 1994, AM J CLIN NUTR, V60, P48, DOI 10.1093/ajcn/60.1.48
   Smith GI, 2019, J CLIN INVEST, V129, P3978, DOI 10.1172/JCI129186
   Smith U, 2016, J INTERN MED, V280, P465, DOI 10.1111/joim.12540
   Sohn JW, 2015, BMB REP, V48, P229, DOI 10.5483/BMBRep.2015.48.4.272
   Soltani N, 2020, DIABET METAB SYND OB, V13, P785, DOI 10.2147/DMSO.S234992
   Spalding KL, 2008, NATURE, V453, P783, DOI 10.1038/nature06902
   Sripetchwandee J, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00496
   Stanhope KL, 2018, OBES REV, V19, P1205, DOI 10.1111/obr.12699
   Starling AP, 2015, AM J CLIN NUTR, V101, P302, DOI 10.3945/ajcn.114.094946
   Stefan N, 2020, LANCET DIABETES ENDO, V8, P616, DOI 10.1016/S2213-8587(20)30110-8
   Stenson BM, 2011, J BIOL CHEM, V286, P370, DOI 10.1074/jbc.M110.179499
   Stephan BCM, 2018, J ALZHEIMERS DIS, V66, P653, DOI 10.3233/JAD-180375
   Steppan CM, 2001, P NATL ACAD SCI USA, V98, P502, DOI 10.1073/pnas.98.2.502
   Stincic TL, 2018, HORM BEHAV, V104, P146, DOI 10.1016/j.yhbeh.2018.04.001
   Stine RR, 2016, MOL METAB, V5, P57, DOI 10.1016/j.molmet.2015.11.001
   Stubbins RE, 2012, EUR J NUTR, V51, P861, DOI 10.1007/s00394-011-0266-4
   SUCOV HM, 1994, GENE DEV, V8, P1007, DOI 10.1101/gad.8.9.1007
   Sun Y., 2020, INT J MAL 6, V21
   Tamashiro KLK, 2009, DIABETES, V58, P1116, DOI 10.2337/db08-1129
   Tanos R, 2012, TOXICOL SCI, V129, P372, DOI 10.1093/toxsci/kfs204
   Tanos R, 2012, HEPATOLOGY, V55, P1994, DOI 10.1002/hep.25571
   Taylor PD, 2007, EXP PHYSIOL, V92, P287, DOI 10.1113/expphysiol.2005.032854
   Temelkova-Kurktschiev T, 2002, METABOLISM, V51, P743, DOI 10.1053/meta.2002.32804
   ter Horst R, 2020, ARTERIOSCL THROM VAS, V40, P1787, DOI 10.1161/ATVBAHA.120.314508
   Thomas EL, 2013, PROG NUCL MAG RES SP, V73, P56, DOI 10.1016/j.pnmrs.2013.04.001
   Thompson BR, 2010, MOL CELL ENDOCRINOL, V318, P24, DOI 10.1016/j.mce.2009.08.015
   Thorp Audrey, 2020, Curr Hepatol Rep, V19, P402, DOI 10.1007/s11901-020-00543-9
   Tilg H, 2020, NAT REV IMMUNOL, V20, P40, DOI 10.1038/s41577-019-0198-4
   Tontonoz P, 1997, P NATL ACAD SCI USA, V94, P237, DOI 10.1073/pnas.94.1.237
   Trovato E, 2019, FRONT PHYSIOL, V10, DOI 10.3389/fphys.2019.00522
   Tsuchida A, 2005, DIABETES, V54, P3358, DOI 10.2337/diabetes.54.12.3358
   Ulven SM, 2005, PROSTAG LEUKOTR ESS, V73, P59, DOI 10.1016/j.plefa.2005.04.009
   Ussar S, 2014, SCI TRANSL MED, V6, DOI 10.1126/scitranslmed.3008490
   Valassi E, 2008, NUTR METAB CARDIOVAS, V18, P158, DOI 10.1016/j.numecd.2007.06.004
   Valdearcos M, 2017, CELL METAB, V26, P185, DOI 10.1016/j.cmet.2017.05.015
   Vangipuram SD, 2007, INT J OBESITY, V31, P87, DOI 10.1038/sj.ijo.0803366
   Vechetti IJ, 2021, J PHYSIOL-LONDON, V599, P845, DOI 10.1113/JP278929
   Vickers MH, 2005, ENDOCRINOLOGY, V146, P4211, DOI 10.1210/en.2005-0581
   VidalPuig AJ, 1997, J CLIN INVEST, V99, P2416, DOI 10.1172/JCI119424
   Vigouroux C, 1998, DIABETES, V47, P490, DOI 10.2337/diabetes.47.3.490
   Virani SS, 2021, CIRCULATION, V143, pe254, DOI 10.1161/CIR.0000000000000950
   Virtue AT, 2019, SCI TRANSL MED, V11, DOI 10.1126/scitranslmed.aav1892
   Vishvanath L, 2019, J CLIN INVEST, V129, P4022, DOI 10.1172/JCI129191
   Voulgari C, 2011, J AM COLL CARDIOL, V58, P1343, DOI 10.1016/j.jacc.2011.04.047
   Vrijheid M, 2020, ENVIRON HEALTH PERSP, V128, DOI 10.1289/EHP5975
   Wada T, 2009, TRENDS ENDOCRIN MET, V20, P273, DOI 10.1016/j.tem.2009.03.003
   Walker BR, 2000, J INTERN MED, V247, P198, DOI 10.1046/j.1365-2796.2000.00609.x
   Wang R, 2021, CELL MOL IMMUNOL, V18, P4, DOI 10.1038/s41423-020-00592-6
   Wang YX, 2003, CELL, V113, P159, DOI 10.1016/S0092-8674(03)00269-1
   Watanabe M, 2011, J BIOL CHEM, V286, P26913, DOI 10.1074/jbc.M111.248203
   Weickert MO, 2008, J NUTR, V138, P439, DOI 10.1093/jn/138.3.439
   Weiss RE, 1998, ENDOCRINOLOGY, V139, P4945, DOI 10.1210/en.139.12.4945
   Whirledge S, 2018, ENDOCRINOLOGY, V159, P46, DOI 10.1210/en.2017-00728
   Whitaker RC, 1998, J PEDIATR-US, V132, P768, DOI 10.1016/S0022-3476(98)70302-6
   Wildman RP, 2008, ARCH INTERN MED, V168, P1617, DOI 10.1001/archinte.168.15.1617
   Williams EP, 2015, CURR OBES REP, V4, P363, DOI 10.1007/s13679-015-0169-4
   Wiss DA, 2017, APPETITE, V115, P19, DOI 10.1016/j.appet.2016.12.019
   Xanthakos SA, 2020, GASTROENTEROLOGY, V159, P1731, DOI 10.1053/j.gastro.2020.07.034
   Xiao H, 2020, FRONT GENET, V11, DOI 10.3389/fgene.2020.00297
   Xu HY, 2003, J CLIN INVEST, V112, P1821, DOI 10.1172/JCI200319451
   Yajnik CS, 2002, J CLIN ENDOCR METAB, V87, P5575, DOI 10.1210/jc.2002-020434
   Yanase T, 2008, J STEROID BIOCHEM, V109, P254, DOI 10.1016/j.jsbmb.2008.03.017
   Yang JY, 2008, OBESITY, V16, P16, DOI 10.1038/oby.2007.24
   Yeh SY, 2002, P NATL ACAD SCI USA, V99, P13498, DOI 10.1073/pnas.212474399
   Yu YH, 2015, OBES REV, V16, P234, DOI 10.1111/obr.12246
   Yu YH, 2017, J DIABETES, V9, P656, DOI 10.1111/1753-0407.12529
   Zabolotny JM, 2002, DEV CELL, V2, P489, DOI 10.1016/S1534-5807(02)00148-X
   Zanchi D, 2017, NEUROSCI BIOBEHAV R, V80, P457, DOI 10.1016/j.neubiorev.2017.06.013
   Zhang YQ, 2012, MOL ENDOCRINOL, V26, P272, DOI 10.1210/me.2011-1157
   Zhao P, 2018, CELL, V172, P731, DOI 10.1016/j.cell.2018.01.007
   Zheng J, 2020, CHINESE MED J-PEKING, V133, P863, DOI 10.1097/CM9.0000000000000731
   Zhou J, 2008, GASTROENTEROLOGY, V134, P556, DOI 10.1053/j.gastro.2007.11.037
   Zhou ZY, 2021, DIABETOLOGIA, V64, P1963, DOI 10.1007/s00125-021-05484-6
   Zhu P, 2013, GEN COMP ENDOCR, V193, P19, DOI 10.1016/j.ygcen.2013.07.004
NR 407
TC 21
Z9 22
U1 11
U2 30
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0006-2952
EI 1873-2968
J9 BIOCHEM PHARMACOL
JI Biochem. Pharmacol.
PD MAY
PY 2022
VL 199
AR 115012
DI 10.1016/j.bcp.2022.115012
EA APR 2022
PG 22
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 1N1ND
UT WOS:000800429000002
PM 35393120
DA 2023-06-08
ER

EF
FN Clarivate Analytics Web of Science
VR 1.0
PT J
AU Meier, K
   Nordestgaard, AT
   Eid, AI
   Kongkaewpaisan, N
   Lee, JM
   Kongwibulwut, M
   Han, KR
   Kokoroskos, N
   Mendoza, AE
   Saillant, N
   King, DR
   Velmahos, GC
   Kaafarani, HMA
AF Meier, Karien
   Nordestgaard, Ask T.
   Eid, Ahmed I.
   Kongkaewpaisan, Napaporn
   Lee, Jae Moo
   Kongwibulwut, Manansun
   Han, Kelsey R.
   Kokoroskos, Nikolaos
   Mendoza, April E.
   Saillant, Noelle
   King, David R.
   Velmahos, George C.
   Kaafarani, Haytham M. A.
TI Obesity as protective against, rather than a risk factor for,
   postoperative Clostridium difficile infection: A nationwide
   retrospective analysis of 1,426,807 surgical patients
SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
LA English
DT Article
DE Obesity; Clostridium difficile infection; ACS NSQIP
ID BODY-MASS INDEX; GUT MICROBIOME; UNDERWEIGHT; METFORMIN; OVERWEIGHT;
   DISEASE; HOSPITALS; DIARRHEA
AB BACKGROUND: Recent studies suggest that obesity is a risk factor for Clostridium difficile infection, possibly due to disruptions in the intestinal microbiome composition. We hypothesized that body mass index (BMI) is associated with increased incidence of C. difficile infection in surgical patients.
   METHODS: In this nationwide retrospective cohort study in 680 American College of Surgeons National Surgical Quality Improvement Program participating sites across the United States, the occurrence of C. difficile infection within 30 days postoperatively between different BMI groups was compared. All American College of Surgeons National Surgical Quality Improvement Program patients between 2015 and 2016 were classified as underweight, normal-weight, overweight, or obese class I-III if their BMI was less than 18.5, 18.5 to 25, 25 to 30, 30 to 35, 35 to 40 or greater than 40, respectively.
   RESULTS: A total of 1,426,807 patients were included; median agewas 58 years, 43.4% were male, and 82.9% were white. The postoperative incidence of C. difficile infection was 0.42% overall: 1.11%, 0.56%, 0.39%, 0.35%, 0.33% and 0.36% from the lowest to the highest BMI group, respectively (p < 0.001 for trend). In univariate then multivariable logistic regression analyses, adjusting for patient demographics (e.g., age, sex), comorbidities (e.g., diabetes, systemic sepsis, immunosuppression), preoperative laboratory values (e.g., albumin, white blood cell count), procedure complexity (work relative unit as a proxy) and procedure characteristics (e.g., emergency, type of surgery [general, vascular, other]), compared with patients with normal BMI, high BMI was inversely and incrementally correlated with the postoperative occurrence of C. difficile infection. The underweight were at increased risk (odds ratio, 1.15 [1.00-1.32]) while the class III obese were at the lowest risk (odds ratio, 0.73 [0.65-0.81]).
   CONCLUSION: In this nationwide retrospective cohort study, obesity is independently and in a stepwise fashion associated with a decreased risk of postoperative C. difficile infection. Further studies are warranted to explore the potential and unexpected association. (Copyright (c) 2019 Wolters Kluwer Health, Inc. All rights reserved.) LEVEL OF EVIDENCE: Prognostic/Epidemiologic, Level IV.
C1 [Meier, Karien; Nordestgaard, Ask T.; Eid, Ahmed I.; Kongkaewpaisan, Napaporn; Lee, Jae Moo; Kongwibulwut, Manansun; Han, Kelsey R.; Kokoroskos, Nikolaos; Mendoza, April E.; Saillant, Noelle; King, David R.; Velmahos, George C.; Kaafarani, Haytham M. A.] Harvard Med Sch, Massachusetts Gen Hosp, Div Trauma Emergency Surg & Surg Crit Care, Dept Surg, Boston, MA 02115 USA.
   [Meier, Karien] Leiden Univ, Med Ctr, Dept Trauma Surg, Leiden, Netherlands.
   [Nordestgaard, Ask T.] Univ Copenhagen, Rigshosp, Ctr Head & Orthopaed, Dept Anaesthesia, Copenhagen, Denmark.
C3 Harvard University; Harvard Medical School; Massachusetts General
   Hospital; Leiden University; Leiden University Medical Center (LUMC);
   Leiden University - Excl LUMC; Rigshospitalet; University of Copenhagen
RP Kaafarani, HMA (通讯作者)，Massachusetts Gen Hosp, Div Trauma Emergency Surg & Surg Crit Care, 165 Cambridge St,Suite 810, Boston, MA 02114 USA.
EM hkaafarani@mgh.harvard.edu
OI Meier, Karien/0000-0003-4855-1576; Nordestgaard, Ask
   Tybjaerg/0000-0002-5500-686X; Lee, Jae Moo/0000-0002-4643-2648
CR ACS NSQIP, 2016, US GUID 2016 ACS NSQ
   Armougom F, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0007125
   Bamgbade OA, 2007, WORLD J SURG, V31, P556, DOI 10.1007/s00268-006-0305-0
   Banaei N, 2015, NEW ENGL J MED, V372, P2368, DOI 10.1056/NEJMc1505190
   Bishara J, 2013, CLIN INFECT DIS, V57, P489, DOI 10.1093/cid/cit280
   Bohnen JD, 2017, ANN SURG, V265, P1119, DOI 10.1097/SLA.0000000000001906
   BURNS HJG, 1988, BAILLIERE CLIN GASTR, V2, P849, DOI 10.1016/0950-3528(88)90038-3
   Cameron AR, 2016, CIRC RES, V119, P652, DOI 10.1161/CIRCRESAHA.116.308445
   Cao HM, 2014, J ENDOCRINOL, V220, pT47, DOI 10.1530/JOE-13-0339
   Chandler RE, 2007, INFECT CONT HOSP EP, V28, P116, DOI 10.1086/511795
   Ciricillo J, 2016, TRANSPL INFECT DIS, V18, P706, DOI 10.1111/tid.12584
   Dallal RM, 2002, ANN SURG, V235, P363, DOI 10.1097/00000658-200203000-00008
   Davenport DL, 2005, ANN SURG, V242, P463, DOI 10.1097/01.sla.0000183348.15117.ab
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   Dobner J, 2018, CLIN MICROBIOL INFEC, V24, P24, DOI 10.1016/j.cmi.2017.02.013
   Eliakim-Raz N, 2015, EUR J CLIN MICROBIOL, V34, P1201, DOI 10.1007/s10096-015-2348-3
   Fine JP, 1999, J AM STAT ASSOC, V94, P496, DOI 10.2307/2670170
   Flegal KM, 2005, JAMA-J AM MED ASSOC, V293, P1861, DOI 10.1001/jama.293.15.1861
   Freckelton J, 2017, SCAND J GASTROENTERO, V52, P969, DOI 10.1080/00365521.2017.1325930
   Gooley TA, 1999, STAT MED, V18, P695, DOI 10.1002/(SICI)1097-0258(19990330)18:6<695::AID-SIM60>3.0.CO;2-O
   Hales Craig M, 2017, NCHS Data Brief, P1
   Hourigan Jon Stuart, 2011, Clin Colon Rectal Surg, V24, P283, DOI 10.1055/s-0031-1295691
   Kazakova SV, 2006, ARCH INTERN MED, V166, P2518, DOI 10.1001/archinte.166.22.2518
   Lagier J., 2016, HUM MICROBIOME J, V2, P10, DOI [10.1016/j.humic.2016.10.003, DOI 10.1016/J.HUMIC.2016.10.003]
   Le Chatelier E, 2013, NATURE, V500, P541, DOI 10.1038/nature12506
   Leung J, 2013, EMERG INFECT DIS, V19, P1791, DOI 10.3201/eid1911.130618
   Madan R, 2015, ANAEROBE, V34, P182, DOI 10.1016/j.anaerobe.2014.12.009
   Mansoor MS, 2015, GASTROENTEROLOGY, V148, pS484
   McDonald LC, 2006, EMERG INFECT DIS, V12, P409, DOI 10.3201/eid1203.051064
   McFarland LV, 2009, CURR OPIN GASTROEN, V25, P24, DOI 10.1097/MOG.0b013e32831da7c4
   Mulki R, 2017, ALIMENT PHARM THER, V45, P75, DOI 10.1111/apt.13832
   Nathanson BH, 2017, INFECTION, V45, P787, DOI 10.1007/s15010-017-1036-x
   Phung DT, 2013, OBES REV, V14, P839, DOI 10.1111/obr.12055
   Punni E, 2015, OBES RES CLIN PRACT, V9, P50, DOI 10.1016/j.orcp.2013.12.007
   Reveles KR, 2014, AM J INFECT CONTROL, V42, P1028, DOI 10.1016/j.ajic.2014.06.011
   Ridaura VK, 2013, SCIENCE, V341, P1079, DOI 10.1126/science.1241214
   Romero-Corral A, 2008, INT J OBESITY, V32, P959, DOI 10.1038/ijo.2008.11
   Saisho Y, 2015, ENDOCR METAB IMMUNE, V15, P196, DOI 10.2174/1871530315666150316124019
   Tan ET, 2007, EMERG INFECT DIS, V13, P498, DOI 10.3201/eid1303.060294
   Tucker CE, 2014, CLIN OBES, V4, P287, DOI 10.1111/cob.12076
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Weitoft GR, 2008, SCAND J PUBLIC HEALT, V36, P169, DOI 10.1177/1403494807085080
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
NR 43
TC 11
Z9 14
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2163-0755
EI 2163-0763
J9 J TRAUMA ACUTE CARE
JI J. Trauma Acute Care Surg.
PD JUN
PY 2019
VL 86
IS 6
BP 1001
EP 1009
DI 10.1097/TA.0000000000002249
PG 9
WC Critical Care Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Surgery
GA IB1CM
UT WOS:000470001200009
PM 31124898
DA 2023-06-08
ER

PT J
AU Guo, WL
   Chen, M
   Pan, WL
   Zhang, Q
   Xu, JX
   Lin, YC
   Li, L
   Liu, B
   Bai, WD
   Zhang, YY
   Ni, L
   Rao, PF
   Lv, XC
AF Guo, Wei-Ling
   Chen, Min
   Pan, Wen-Li
   Zhang, Qing
   Xu, Jia-Xin
   Lin, Yi-Chen
   Li, Lu
   Liu, Bin
   Bai, Wei-Dong
   Zhang, Yan-Yan
   Ni, Li
   Rao, Ping-Fan
   Lv, Xu-Cong
TI Hypoglycemic and hypolipidemic mechanism of organic chromium derived
   from chelation of Grifola frondosa polysaccharide-chromium (III) and its
   modulation of intestinal microflora in high fat-diet and STZ-induced
   diabetic mice
SO INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
LA English
DT Article
DE Organic chromium; Grifola frondosa polysaccharide; Hypoglycemic and
   hypolipidemic activities; Intestinal microflora; Hepatic mRNA expression
ID STRUCTURAL-CHARACTERIZATION; OBESITY; ACID; HETEROPOLYSACCHARIDE;
   HYPERLIPIDEMIA; HYPERGLYCEMIA; INFLAMMATION; METFORMIN; DISEASE; CULTURE
AB Polysaccharide from Grifola frondosa is an excellent metal-ion chelating agent owing to its distinctive structure and outstanding functional activities. Our previous research has successfully synthesized novel organic chromium derived from the chelation of G. frondosa polysaccharide-chromium (III) [GFP-Cr(III)]. The purpose of present research was to reveal the hypoglycemic and hypolipidemic mechanism of GFP-Cr (III), and its relationship with the modulation of intestinal microflora. Successful fabrication of GFP-Cr(III) was verified by thermogravimetric analysis (TGA), powder X-ray diffraction (XRD) and H-1 NMR spectrum. The hypoglycemic and hypolipidemic effects were examined using type 2 diabetic mice induced by a high-fat diet (HFD) and streptozocin (STZ). Results indicated that GFP-Cr(III) intervention improved abnormal serum biochemical indicators (triglyceride (TG), cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and glucose), inhibited lipid accumulation and steatosis in the liver. Metagenomic analysis revealed that GFP-Cr(III) treatment produced obvious changes on the intestinal microflora in T2DM mice. The correlation network analysis further revealed that the serum and hepatic lipid profiles were positively correlated with Streptococcus and Enterococcus, but negatively correlated with Enterorhabdus, Ruminococcaceae-UCG-011, Coriobacteriaceae and Micrococcaceae. Meanwhile, oral administration with GFP-Cr(III) regulated the mRNA expression related to glucose and lipid metabolism. These results of present study suggest that GFP-Cr(III) could be used as potential functional food ingredients for the amelioration of hyperglycemia and hyperlipidemia. (C) 2019 Elsevier B.V. All rights reserved.
C1 [Guo, Wei-Ling; Chen, Min; Pan, Wen-Li; Zhang, Yan-Yan; Ni, Li; Rao, Ping-Fan; Lv, Xu-Cong] Fuzhou Univ, Coll Biol Sci & Technol, Inst Food Sci & Technol, Fuzhou 350108, Fujian, Peoples R China.
   [Guo, Wei-Ling; Chen, Min; Zhang, Qing; Xu, Jia-Xin; Lin, Yi-Chen; Li, Lu; Liu, Bin; Lv, Xu-Cong] Fujian Agr & Forestry Univ, Natl Engn Res Ctr JUNCAO Technol, Fuzhou 350002, Fujian, Peoples R China.
   [Bai, Wei-Dong; Lv, Xu-Cong] Zhongkai Univ Agr & Engn, Coll Light Ind & Food Sci, Guangzhou 510225, Guangdong, Peoples R China.
   [Zhang, Yan-Yan] Univ Hohenheim, Inst Food Sci & Biotechnol, Dept Flavor Chem, D-70599 Stuttgart, Germany.
   [Liu, Bin; Lv, Xu-Cong] Fujian Agr & Forestry Univ, Coll Food Sci, Fuzhou 350002, Fujian, Peoples R China.
C3 Chinese Academy of Agricultural Sciences; Institute of Food Science &
   Technology, CAAS; Fuzhou University; Fujian Agriculture & Forestry
   University; Zhongkai University of Agriculture & Engineering; University
   Hohenheim; Fujian Agriculture & Forestry University
RP Lv, XC (通讯作者)，Fuzhou Univ, Coll Biol Sci & Technol, Inst Food Sci & Technol, Fuzhou 350108, Fujian, Peoples R China.
EM xucong1154@163.com
RI Zhang, Yanyan/AFT-0833-2022; Lv, Xu-Cong/AAP-8623-2020; Xu,
   Jiaxin/GPS-4486-2022
OI Lv, Xu-Cong/0000-0002-0594-4284; Xu, Jiaxin/0000-0003-3297-7118; Zhang,
   Yanyan/0000-0002-2827-8042; chen, min/0000-0001-8033-9116
FU Natural Science Foundation of Fujian Province [2019J06013]; National
   Natural Science Foundation of China [31601466]; fund for outstanding
   young scientific talents of Fujian Agriculture and Forestry University
   [XJQ201607]; National Key R&D Program of China [2018YFD0901003]; China
   Postdoctoral Science Foundation [2016T90591]
FX This work was supported by funding from Natural Science Foundation of
   Fujian Province (2019J06013), National Natural Science Foundation of
   China (No. 31601466), fund for outstanding young scientific talents of
   Fujian Agriculture and Forestry University (XJQ201607), National Key R&D
   Program of China (2018YFD0901003), Project Funded by China Postdoctoral
   Science Foundation (2016T90591).
CR Al-Harbi NO, 2018, INT IMMUNOPHARMACOL, V58, P24, DOI 10.1016/j.intimp.2018.02.023
   Alva-Murillo N, 2012, VET MICROBIOL, V155, P324, DOI 10.1016/j.vetmic.2011.08.025
   [Anonymous], [No title captured]
   [Anonymous], [No title captured]
   [Anonymous], [No title captured]
   [Anonymous], [No title captured]
   [Anonymous], [No title captured]
   Bae J, 2019, J NUTR BIOCHEM, V64, P152, DOI 10.1016/j.jnutbio.2018.10.014
   Bezerra ID, 2019, CARBOHYD POLYM, V210, P254, DOI 10.1016/j.carbpol.2019.01.025
   Byndloss MX, 2018, NAT REV MICROBIOL, V16, P103, DOI 10.1038/nrmicro.2017.158
   Chen YY, 2018, INT J BIOL MACROMOL, V120, P1087, DOI 10.1016/j.ijbiomac.2018.08.160
   Chen YQ, 2018, CARBOHYD POLYM, V198, P452, DOI 10.1016/j.carbpol.2018.06.077
   Chiu CY, 2017, J FOOD DRUG ANAL, V25, P919, DOI 10.1016/j.jfda.2016.11.015
   Delzenne NM, 2011, ANNU REV NUTR, V31, P15, DOI 10.1146/annurev-nutr-072610-145146
   Ding MF, 2019, FOOD FUNCT, V10, P554, DOI [10.1039/c8fo02182a, 10.1039/C8FO02182A]
   Fabbrini E, 2010, HEPATOLOGY, V51, P679, DOI 10.1002/hep.23280
   Fan YN, 2011, INT J BIOL MACROMOL, V48, P798, DOI 10.1016/j.ijbiomac.2011.03.013
   Feng KL, 2019, J AGR FOOD CHEM, V67, P2476, DOI 10.1021/acs.jafc.8b05632
   Fernandes JD, 2016, DIABETES RES CLIN PR, V117, P48, DOI 10.1016/j.diabres.2016.04.016
   Gao Z, 2018, CARBOHYD POLYM, V181, P1224, DOI 10.1016/j.carbpol.2017.12.007
   Goncalves FJ, 2018, FOOD CHEM, V243, P1, DOI 10.1016/j.foodchem.2017.09.097
   Gujjala S, 2016, BIOMED PHARMACOTHER, V84, P215, DOI 10.1016/j.biopha.2016.09.029
   Guo WL, 2019, INT J BIOL MACROMOL, V131, P81, DOI 10.1016/j.ijbiomac.2019.03.042
   Guo WL, 2018, FOOD FUNCT, V9, P3419, DOI 10.1039/c8fo00836a
   Hentati F, 2018, CARBOHYD POLYM, V198, P589, DOI 10.1016/j.carbpol.2018.06.098
   Hou GH, 2019, CARBOHYD POLYM, V206, P446, DOI 10.1016/j.carbpol.2018.09.067
   Huang S, 2014, J DIABETES RES, V2014, DOI 10.1155/2014/717219
   JEEJEEBHOY KN, 1977, AM J CLIN NUTR, V30, P531
   Kastele X, 2014, EUR J PHARM BIOPHARM, V86, P469, DOI 10.1016/j.ejpb.2013.11.003
   Kim M, 2017, J FUNCT FOODS, V37, P658, DOI 10.1016/j.jff.2017.08.036
   Kothari D, 2018, BIOMED PHARMACOTHER, V105, P377, DOI 10.1016/j.biopha.2018.05.138
   Langley G, 2016, CLIN INFECT DIS, V62, P845, DOI 10.1093/cid/civ1032
   Lechner PS, 2001, J BIOL CHEM, V276, P22675, DOI 10.1074/jbc.M102422200
   Lee BC, 2003, ENZYME MICROB TECH, V32, P574, DOI 10.1016/S0141-0229(03)00026-7
   Li L, 2019, FOOD FUNCT, V10, P2560, DOI [10.1039/C9FO00075E, 10.1039/c9fo00075e]
   Li XF, 2018, J FUNCT FOODS, V49, P510, DOI 10.1016/j.jff.2018.09.016
   Liu HB, 2019, FASEB J, V33, P4490, DOI 10.1096/fj.201801221RR
   Liu W, 2018, CARBOHYD POLYM, V197, P215, DOI 10.1016/j.carbpol.2018.05.067
   Ma XL, 2014, GLYCOCONJUGATE J, V31, P355, DOI 10.1007/s10719-014-9526-x
   Million M, 2016, SCI REP-UK, V6, DOI 10.1038/srep26051
   Mithieux G, 1997, EUR J ENDOCRINOL, V136, P137, DOI 10.1530/eje.0.1360137
   Nandi G, 2019, CARBOHYD POLYM, V215, P213, DOI 10.1016/j.carbpol.2019.03.088
   Novotnik B, 2016, CHEMOSPHERE, V154, P124, DOI 10.1016/j.chemosphere.2016.03.118
   Ogurtsova K, 2017, DIABETES RES CLIN PR, V128, P40, DOI 10.1016/j.diabres.2017.03.024
   Okon EB, 2007, CAN J PHYSIOL PHARM, V85, P562, DOI 10.1139/Y07-026
   Oliveira WH, 2016, BRAIN RES, V1644, P149, DOI 10.1016/j.brainres.2016.05.013
   Ossenkopp KP, 2012, BEHAV BRAIN RES, V227, P134, DOI 10.1016/j.bbr.2011.10.045
   Refat MS, 2017, SPECTROCHIM ACTA A, V173, P122, DOI 10.1016/j.saa.2016.08.053
   Rosenblit PD, 2016, CARDIOVASC DIABETOL, V15, DOI 10.1186/s12933-016-0412-7
   Saravanan S, 2015, EUR J PHARMACOL, V761, P279, DOI 10.1016/j.ejphar.2015.05.034
   Shi JM, 2013, INT J BIOL MACROMOL, V60, P341, DOI 10.1016/j.ijbiomac.2013.06.001
   Spiegelman BM, 2001, CELL, V104, P531, DOI 10.1016/S0092-8674(01)00240-9
   Staniek H, 2010, FOOD CHEM TOXICOL, V48, P89, DOI 10.1016/j.fct.2009.09.020
   Tsave O, 2018, J INORG BIOCHEM, V184, P50, DOI 10.1016/j.jinorgbio.2018.02.001
   Wang HY, 2019, CARBOHYD POLYM, V211, P39, DOI 10.1016/j.carbpol.2019.01.101
   Wang J, 2017, BIOMED PHARMACOTHER, V95, P1669, DOI 10.1016/j.biopha.2017.09.104
   Wang J, 2015, INT J BIOL MACROMOL, V75, P210, DOI 10.1016/j.ijbiomac.2015.01.041
   Wu MJ, 2006, J AGR FOOD CHEM, V54, P2906, DOI 10.1021/jf052893q
   Wu T, 2016, J ETHNOPHARMACOL, V190, P22, DOI 10.1016/j.jep.2016.05.056
   Yan Y, 2019, OBES SURG, V29, P2912, DOI 10.1007/s11695-019-03918-0
   Yang BK, 2002, J MICROBIOL BIOTECHN, V12, P957
   Ye H, 2019, BIOORG CHEM, V88, DOI 10.1016/j.bioorg.2019.102942
   Zhang XY, 2016, NUTR RES, V36, P349, DOI 10.1016/j.nutres.2015.12.002
   Zhang Y, 2019, INT J BIOL MACROMOL, V121, P1029, DOI 10.1016/j.ijbiomac.2018.10.068
   Zhao C, 2016, CARBOHYD POLYM, V144, P382, DOI 10.1016/j.carbpol.2015.12.005
NR 65
TC 46
Z9 50
U1 7
U2 126
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29a, 1043 NX AMSTERDAM, NETHERLANDS
SN 0141-8130
EI 1879-0003
J9 INT J BIOL MACROMOL
JI Int. J. Biol. Macromol.
PD FEB 15
PY 2020
VL 145
BP 1208
EP 1218
DI 10.1016/j.ijbiomac.2019.09.206
PG 11
WC Biochemistry & Molecular Biology; Chemistry, Applied; Polymer Science
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry; Polymer Science
GA KN9VX
UT WOS:000515196500125
PM 31726162
DA 2023-06-08
ER

PT J
AU Chen, YY
   Liu, S
   Leng, SX
AF Chen, Yiyin
   Liu, Sally
   Leng, Sean X.
TI Chronic Low-grade Inflammatory Phenotype (CLIP) and Senescent Immune
   Dysregulation
SO CLINICAL THERAPEUTICS
LA English
DT Review
DE CLIP; inflammaging; frailty; immune senescent remodeling;
   cytomegalovirus; aging
ID REGULATORY T-CELLS; C-REACTIVE PROTEIN; OLDER WOMEN;
   CYTOMEGALOVIRUS-INFECTION; CARDIOVASCULAR-DISEASE; SYSTEMIC
   INFLAMMATION; RHEUMATOID-ARTHRITIS; SERUM INTERLEUKIN-6; GERIATRIC
   SYNDROME; ENERGY-METABOLISM
AB Purpose: The aim was to provide an overview of chronic low-grade inflammatory phenotype (CLIP) and evidence for its role in the pathogenesis of frailty and other chronic conditions as well as potential causative factors and interventions.
   Methods: We reviewed evidence from published clinical and laboratory studies and summarized the opinions of experts from published reviews.
   Findings: CLIP is a low-grade, systemic, unresolved, and smoldering chronic inflammatory state clearly indicated by a 2- to 4-fold increase in serum levels of inflammatory mediators, such as interleukin-6 and C-reactive protein. It involves many other cellular and molecular inflammatory mediators. CLIP typically occurs during aging, also known as "inflammaging," and is an integral part of the spectrum of immunosenescence. Causative factors likely include persistent viral infections, particularly chronic cytomegalovirus infection, cellular senescence, failure to eliminate degraded materials and waste products, dysregulated microbiota and gut permeability, obesity, and others. Substantial evidence supports CLIP as a powerful contributing factor to frailty and many other chronic conditions and adverse health outcomes. Many of the inflammatory mediators and their regulatory mechanisms in CLIP may serve as potential targets for therapeutic intervention. However, development of new interventional strategies for CLIP and its associated chronic conditions should take the complexity of the inflammatory network into consideration. Nonpharmacologic interventions, such as caloric restriction and exercise, may have significant impact on CLIP and its causative factors, leading to substantial health benefits. Metformin and resveratrol have anti-inflammatory property and may serve as a promising therapeutic agent for treatment of CLIP and frailty.
   Implications: CLIP is a chronic inflammatory pathophysiologic process that plays an important role in the pathogenesis of frailty and many other chronic conditions. Improving our understanding of this phenotype may provide opportunities to identify potential targets of effective prevention and therapeutic strategies for frailty and other CLIP associated conditions. (C) 2019 Published by Elsevier Inc.
C1 [Chen, Yiyin] Cent S Univ, Xianga Hosp 2, Div Geriatr, Changsha, Hunan, Peoples R China.
   [Liu, Sally; Leng, Sean X.] Johns Hopkins Univ, Sch Med, Dept Med, Div Geriatr Med & Gerontol, Baltimore, MD 21205 USA.
C3 Central South University; Johns Hopkins University
RP Leng, SX (通讯作者)，Johns Hopkins Univ, Sch Med, Johns Hopkins Asthma & Allergy Ctr, Div Geriatr Med & Gerontol,Dept Med, Room 1A-38A,5501 Hopkins Bayview Circle, Baltimore, MD 21224 USA.
EM sleng1@jhmi.edu
RI Chen, Yiyin/ISA-3880-2023
FU National Institutes of Health [R21-AG-043874, R01AI108907]; Fundamental
   Research Funds for the Central Universities of Central South University
   - Central South University [2016zzts150]; Milstein Medical Asian
   American Partnership (MMAAP) Foundation
FX This work was supported in part by National Institutes of Health grants
   R21-AG-043874 and R01AI108907, the Fundamental Research Funds for the
   Central Universities of Central South University granted by the Central
   South University (grant 2016zzts150), and by funding from the Milstein
   Medical Asian American Partnership (MMAAP) Foundation
   (http://www.mmaapf.org) to Dr. S.X. Leng.
CR [Anonymous], [No title captured]
   Barzilai N, 2016, CELL METAB, V23, P1060, DOI 10.1016/j.cmet.2016.05.011
   Borodkina AV, 2018, ACTA NATURAE, V10, P4, DOI 10.32607/20758251-2018-10-1-4-14
   Cameron AR, 2016, CIRC RES, V119, P652, DOI 10.1161/CIRCRESAHA.116.308445
   Chaves PHM, 2005, J GERONTOL A-BIOL, V60, P729, DOI 10.1093/gerona/60.6.729
   Chen XJ, 2014, CLIN INTERV AGING, V9, P433, DOI 10.2147/CIA.S45300
   Chovatiya R, 2014, MOL CELL, V54, P281, DOI 10.1016/j.molcel.2014.03.030
   Clement K, 2004, FASEB J, V18, P1657, DOI 10.1096/fj.04-2204com
   Collerton J, 2012, MECH AGEING DEV, V133, P456, DOI 10.1016/j.mad.2012.05.005
   De Fanis U, 2008, J AM GERIATR SOC, V56, P904, DOI 10.1111/j.1532-5415.2008.01673.x
   Feldmann M, 1996, J ROY COLL PHYS LOND, V30, P560
   Ferrucci L, 2018, NAT REV CARDIOL, V15, P505, DOI 10.1038/s41569-018-0064-2
   Feuerer M, 2009, NAT IMMUNOL, V10, P689, DOI 10.1038/ni.1760
   Franceschi C, 2000, ANN NY ACAD SCI, V908, P244
   Franceschi C, 2014, J GERONTOL A-BIOL, V69, pS4, DOI 10.1093/gerona/glu057
   Fried LP, 2009, J GERONTOL A-BIOL, V64, P1049, DOI 10.1093/gerona/glp076
   Fried LP, 2001, J GERONTOL A-BIOL, V56, pM146, DOI 10.1093/gerona/56.3.M146
   Goldberg EL, 2015, IMMUNOL REV, V265, P63, DOI 10.1111/imr.12295
   Guarner V, 2015, INTERD T GERONT GERI, V40, P99, DOI 10.1159/000364934
   Illan-Gomez F, 2012, OBES SURG, V22, P950, DOI 10.1007/s11695-012-0643-y
   Jagger A, 2014, GERONTOLOGY, V60, P130, DOI 10.1159/000355303
   Jankord R, 2004, MED SCI SPORT EXER, V36, P960, DOI 10.1249/01.MSS.0000128186.09416.18
   Kalain R, 2006, J GERONTOL A-BIOL, V61, P211, DOI 10.1093/gerona/61.3.211
   Kirk GD, 2017, FRONT IMMUNOL, V8, DOI 10.3389/fimmu.2017.01343
   Krabbe KS, 2004, EXP GERONTOL, V39, P687, DOI 10.1016/j.exger.2004.01.009
   Lawrence T, 2002, NAT REV IMMUNOL, V2, P787, DOI 10.1038/nri915
   Leng S, 2002, J AM GERIATR SOC, V50, P1268, DOI 10.1046/j.1532-5415.2002.50315.x
   Leng SX, 2007, J AM GERIATR SOC, V55, P864, DOI 10.1111/j.1532-5415.2007.01186.x
   Leng SX, 2015, AIDS RES HUM RETROV, V31, P1257, DOI [10.1089/aid.2015.0134, 10.1089/AID.2015.0134]
   Leng SX, 2011, EXP GERONTOL, V46, P679, DOI 10.1016/j.exger.2011.04.002
   Leng SX, 2011, AGE AGEING, V40, P475, DOI 10.1093/ageing/afr047
   Leng SX, 2011, AGE, V33, P607, DOI 10.1007/s11357-011-9205-9
   Leng SX, 2009, J GERONTOL A-BIOL, V64, P499, DOI 10.1093/gerona/gln047
   Leng SX, 2009, EXP GERONTOL, V44, P511, DOI 10.1016/j.exger.2009.05.005
   Leng SX, 2004, AGING CLIN EXP RES, V16, P153
   Li HF, 2014, J INFECT DIS, V210, P400, DOI 10.1093/infdis/jiu093
   Li HF, 2014, EXP GERONTOL, V54, P84, DOI 10.1016/j.exger.2014.01.010
   Libby P, 2011, NATURE, V473, P317, DOI 10.1038/nature10146
   Loetscher P, 1998, NATURE, V391, P344, DOI 10.1038/34814
   Mao GX, 2016, MECH AGEING DEV, V158, P62, DOI 10.1016/j.mad.2015.12.005
   Margolick JB, 2018, J INFECT DIS, V218, P249, DOI 10.1093/infdis/jiy005
   Mathei C, 2011, J AM GERIATR SOC, V59, P2201, DOI 10.1111/j.1532-5415.2011.03719.x
   McDade TW, 2012, P NATL ACAD SCI USA, V109, P17281, DOI 10.1073/pnas.1202244109
   Medina CB, 2016, CELL DEATH DIFFER, V23, P979, DOI 10.1038/cdd.2016.13
   Michelon E, 2006, J GERONTOL A-BIOL, V61, P600, DOI 10.1093/gerona/61.6.600
   Minihane AM, 2015, BRIT J NUTR, V114, P999, DOI 10.1017/S0007114515002093
   Naeger DM, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0008886
   Newman AB, 2001, J GERONTOL A-BIOL, V56, pM158, DOI 10.1093/gerona/56.3.M158
   Pawelec G, 2005, IMMUNOL REV, V205, P257, DOI 10.1111/j.0105-2896.2005.00271.x
   Qu T, 2009, MECH AGEING DEV, V130, P161, DOI 10.1016/j.mad.2008.10.005
   Rampelli S, 2013, AGING-US, V5, P902, DOI 10.18632/aging.100623
   Ridker PM, 2017, NEW ENGL J MED, V377, P1119, DOI 10.1056/NEJMoa1707914
   Ridker PM, 2009, CLIN CHEM, V55, P209, DOI 10.1373/clinchem.2008.119214
   Rocha VZ, 2009, NAT REV CARDIOL, V6, P399, DOI 10.1038/nrcardio.2009.55
   Sansoni P, 2014, EXP GERONTOL, V55, P54, DOI 10.1016/j.exger.2014.03.020
   Schmaltz HN, 2005, J AM GERIATR SOC, V53, P747, DOI 10.1111/j.1532-5415.2005.53250.x
   Semba RD, 2005, EXP GERONTOL, V40, P81, DOI 10.1016/j.exger.2004.09.006
   Serio I, 2018, DRUG TODAY, V54, P219, DOI 10.1358/dot.2018.54.3.2788019
   Sylwester AW, 2005, J EXP MED, V202, P673, DOI 10.1084/jem.20050882
   Thevaranjan N, 2017, CELL HOST MICROBE, V21, P455, DOI 10.1016/j.chom.2017.03.002
   Timmers S, 2011, CELL METAB, V14, P612, DOI 10.1016/j.cmet.2011.10.002
   Vasto S, 2007, ANN NY ACAD SCI, V1100, P111, DOI 10.1196/annals.1395.009
   Walston J, 2002, ARCH INTERN MED, V162, P2333, DOI 10.1001/archinte.162.20.2333
   Ye JP, 2010, AGING-US, V2, P361, DOI 10.18632/aging.100155
   Zomer E, 2016, OBES REV, V17, P1001, DOI 10.1111/obr.12433
NR 65
TC 27
Z9 27
U1 0
U2 9
PU ELSEVIER
PI BRIDGEWATER
PA 685 ROUTE 202-206, BRIDGEWATER, NJ 08807 USA
SN 0149-2918
EI 1879-114X
J9 CLIN THER
JI Clin. Ther.
PD MAR
PY 2019
VL 41
IS 3
BP 400
EP 409
DI 10.1016/j.clinthera.2019.02.001
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pharmacology & Pharmacy
GA HT5TF
UT WOS:000464625500005
PM 30833113
OA Bronze
DA 2023-06-08
ER

PT J
AU Zhu, LL
   Ma, ZJ
   Ren, M
   Wei, YM
   Liao, YH
   Shen, YL
   Fan, SM
   Li, L
   Wu, QX
   Gao, ZS
   Song, JF
   Ma, YL
AF Zhu, Lu-lu
   Ma, Zhi-jun
   Ren, Ming
   Wei, Yu-miao
   Liao, Yu-hua
   Shen, You-lu
   Fan, Shi-ming
   Li, Lin
   Wu, Qing-xia
   Gao, Zhong-shan
   Song, Jing-fu
   Ma, Yu-lan
TI Distinct Features of Gut Microbiota in High-Altitude Tibetan and
   Middle-Altitude Han Hypertensive Patients
SO CARDIOLOGY RESEARCH AND PRACTICE
LA English
DT Article
ID AKKERMANSIA-MUCINIPHILA; INFLAMMATION; ENDOTOXEMIA; DIVERSITY; METFORMIN
AB Indigenous animals show unique gut microbiota (GM) in the Tibetan plateau. However, it is unknown whether the hypertensive indigenous people in plateau also have the distinct gut bacteria, different from those living in plains. We sequenced the V3-V4 region of the gut bacteria 16S ribosomal RNA (rRNA) gene of feces samples among hypertensive patients (HPs) and healthy individuals (HIs) from 3 distinct altitudes: Tibetans from high altitude (3600-4500 m, n = 38 and 34), Hans from middle altitude (2260 m, n = 49 and 35), and Hans from low altitude (13 m, n = 34 and 35) and then analyzed the GM composition among hypertensive and healthy subgroups using the bioinformatics analysis, respectively. The GM of high-altitude Tibetan and middle-altitude Han HPs presented greater alpha- and beta-diversities, lower ratio of Firmicutes/Bacteroidetes (F/B), and higher abundance of beneficial Verrucomicrobia and Akkermansia than the low-altitudes HPs did. The GM of high-altitude Tibetan and middle-altitude HIs showed greater alpha-diversity and lower ratio of F/B than the low-altitudes HIs did. But, beta-diversity and abundance of Verrucomicrobia and Akkermansia among different subgroups of HIs did not show any differences. Conclusively, the high-altitude Tibetan and middle-altitude Han HPs have a distinct feature of GM, which may be important in their adaptation to hypertension in the plateau environments.
C1 [Zhu, Lu-lu; Ren, Ming; Shen, You-lu; Fan, Shi-ming; Li, Lin; Wu, Qing-xia; Gao, Zhong-shan; Ma, Yu-lan] Qinghai Univ, Affiliated Hosp, Dept Cardiol, Xining 810001, Peoples R China.
   [Ma, Zhi-jun] Qinghai Univ, Affiliated Hosp, Dept Surg Oncol, Xining 810001, Peoples R China.
   [Wei, Yu-miao; Liao, Yu-hua] Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Lab Cardiovasc Immunol,Inst Cardiol, Wuhan 430074, Peoples R China.
   [Song, Jing-fu] Qinghai Univ, Affiliated Hosp, Dept Urol, Xining 810001, Peoples R China.
C3 Qinghai University; Qinghai University; Huazhong University of Science &
   Technology; Qinghai University
RP Ma, YL (通讯作者)，Qinghai Univ, Affiliated Hosp, Dept Cardiol, Xining 810001, Peoples R China.
EM 1305321913@qq.com; 41146279@qq.com; qhrm-0971@163.com; yumiaowei@qq.com;
   liaoyh27@163.com; 3166875870@qq.com; 2172083996@qq.com;
   2522788873@qq.com; 2461505098@qq.com; 1461415329@qq.com;
   1284586373@qq.com; mylfamai@163.com
FU Sangon BioTech (Shanghai, China); National Natural Science Foundation of
   China [81760084]; Qinghai Provincial Science and Technology Foundation
   [2017-ZJ-921Q, 2018-ZJ-934Q]; Qinghai Province Clinical Research Center
   Foundation [2019-SF-L2]
FX Our work was approved and supported by the Sangon BioTech (Shanghai,
   China). The authors sincerely thank all volunteers who took part in this
   study. The authors would also like to thank all the researchers, support
   staff, and students of Affiliated Hospital, Qinghai University and Union
   Hospital, Tongji Medical College, and Huazhong University of Science and
   Technology for their support and dedication. This work was financially
   supported by the National Natural Science Foundation of China (no.
   81760084), Qinghai Provincial Science and Technology Foundation (nos.
   2017-ZJ-921Q and 2018-ZJ-934Q), and Qinghai Province Clinical Research
   Center Foundation (no. 2019-SF-L2).
CR Bestion E, 2017, NAT ECOL EVOL, V1, DOI 10.1038/s41559-017-0161
   Bo TB, 2019, ISME J, V13, P3037, DOI 10.1038/s41396-019-0492-y
   Bradley CA, 2017, NAT REV GASTRO HEPAT, V14, DOI 10.1038/nrgastro.2017.73
   Cani PD, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.01765
   Caporaso JG, 2010, NAT METHODS, V7, P335, DOI 10.1038/nmeth.f.303
   Cardman Z, 2014, APPL ENVIRON MICROB, V80, P3749, DOI 10.1128/AEM.00899-14
   Chevalier C, 2015, CELL, V163, P1360, DOI 10.1016/j.cell.2015.11.004
   Cox AJ, 2015, LANCET DIABETES ENDO, V3, P207, DOI 10.1016/S2213-8587(14)70134-2
   De Filippo C, 2010, P NATL ACAD SCI USA, V107, P14691, DOI 10.1073/pnas.1005963107
   Deschasaux M, 2018, NAT MED, V24, P1526, DOI 10.1038/s41591-018-0160-1
   Edgar RC, 2013, NAT METHODS, V10, P996, DOI [10.1038/nmeth.2604, 10.1038/NMETH.2604]
   Edgar RC, 2011, BIOINFORMATICS, V27, P2194, DOI 10.1093/bioinformatics/btr381
   Edgar RC, 2010, BIOINFORMATICS, V26, P2460, DOI 10.1093/bioinformatics/btq461
   Ehlers S, 2010, TRENDS IMMUNOL, V31, P184, DOI 10.1016/j.it.2010.02.003
   Erridge C, 2007, AM J CLIN NUTR, V86, P1286, DOI 10.1093/ajcn/86.5.1286
   Fontaine SS, 2018, J EXP BIOL, V221, DOI 10.1242/jeb.187559
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Fujio-Vejar S, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.01221
   Goodrich JK, 2014, CELL, V159, P789, DOI 10.1016/j.cell.2014.09.053
   Han F, 2018, J AGR FOOD CHEM, V66, P6326, DOI 10.1021/acs.jafc.8b01891
   Hansen MEB, 2019, GENOME BIOL, V20, DOI 10.1186/s13059-018-1616-9
   He Y, 2018, NAT MED, V24, P1532, DOI 10.1038/s41591-018-0164-x
   Jia ZL, 2020, MSYSTEMS, V5, DOI 10.1128/mSystems.00660-19
   Jufri NF, 2015, VASC CELL, V7, DOI 10.1186/s13221-015-0033-z
   Karl JP, 2018, AM J PHYSIOL-GASTR L, V315, pG1003, DOI 10.1152/ajpgi.00253.2018
   Kelly D, 2005, TRENDS IMMUNOL, V26, P326, DOI 10.1016/j.it.2005.04.008
   Khalesi S, 2014, HYPERTENSION, V64, P897, DOI 10.1161/HYPERTENSIONAHA.114.03469
   Kleessen B, 2005, MED SCI SPORT EXER, V37, P1313, DOI 10.1249/01.mss.0000174888.22930.e0
   Koliada A, 2017, BMC MICROBIOL, V17, DOI 10.1186/s12866-017-1027-1
   Kumar A, 2016, BMC MICROBIOL, V16, DOI 10.1186/s12866-016-0700-0
   Ley RE, 2006, CELL, V124, P837, DOI 10.1016/j.cell.2006.02.017
   Li J, 2016, CIRCULATION, V133, P2434, DOI 10.1161/CIRCULATIONAHA.115.019645
   Li J, 2017, MICROBIOME, V5, DOI 10.1186/s40168-016-0222-x
   Li LH, 2015, SCI REP-UK, V5, DOI 10.1038/srep09028
   Liu HH, 2019, MICROBIOME, V7, DOI 10.1186/s40168-019-0683-9
   Magoc T, 2011, BIOINFORMATICS, V27, P2957, DOI 10.1093/bioinformatics/btr507
   Marchesi JR, 2016, GUT, V65, P330, DOI 10.1136/gutjnl-2015-309990
   Mariat D, 2009, BMC MICROBIOL, V9, DOI 10.1186/1471-2180-9-123
   Moreno-Indias I, 2015, EUR RESPIR J, V45, P1055, DOI 10.1183/09031936.00184314
   Norlander AE, 2018, J EXP MED, V215, P21, DOI 10.1084/jem.20171773
   Peng Y, 2011, MOL BIOL EVOL, V28, P1075, DOI 10.1093/molbev/msq290
   Quast C, 2013, NUCLEIC ACIDS RES, V41, pD590, DOI 10.1093/nar/gks1219
   Shen J, 2016, ARTERIOSCL THROM VAS, V36, P1448, DOI 10.1161/ATVBAHA.116.307597
   Sun S, 2019, HYPERTENSION, V73, P998, DOI 10.1161/HYPERTENSIONAHA.118.12109
   Tap J, 2015, ENVIRON MICROBIOL, V17, P4954, DOI 10.1111/1462-2920.13006
   Wilck N, 2017, NATURE, V551, P585, DOI 10.1038/nature24628
   Yang YZ, 2017, GASTROENTEROLOGY, V152, P851, DOI 10.1053/j.gastro.2016.11.018
NR 47
TC 4
Z9 5
U1 1
U2 12
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2090-8016
EI 2090-0597
J9 CARDIOL RES PRACT
JI Cardiol. Res. Pract.
PD NOV 21
PY 2020
VL 2020
AR 1957843
DI 10.1155/2020/1957843
PG 15
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA PB7KN
UT WOS:000596495700001
PM 33294219
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Simoens, C
   Philippaert, K
   Wuyts, C
   Goscinny, S
   Van Hoeck, E
   Van Loco, J
   Billen, J
   de Hoon, J
   Ampe, E
   Vangoitsenhoven, R
   Mertens, A
   Vennekens, R
   Van der Schueren, B
AF Simoens, Caroline
   Philippaert, Koenraad
   Wuyts, Caroline
   Goscinny, Severine
   Van Hoeck, Els
   Van Loco, Joris
   Billen, Jaak
   de Hoon, Jan
   Ampe, Els
   Vangoitsenhoven, Roman
   Mertens, Ann
   Vennekens, Rudi
   Van der Schueren, Bart
TI Pharmacokinetics of Oral Rebaudioside A in Patients with Type 2 Diabetes
   Mellitus and Its Effects on Glucose Homeostasis: A Placebo-Controlled
   Crossover Trial
SO EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS
LA English
DT Article
ID GLYCOSIDIC SWEETENERS; NATURAL SWEETENER; STEVIOL GLYCOSIDE; METABOLISM;
   ABSORPTION; MIXTURE; INSULIN
AB Background and Objectives Rebaudioside A, a steviol glycoside, is deglycosylated by intestinal microflora prior to the absorption of steviol and conjugation to steviol glucuronide. While glucose-lowering properties are observed for rebaudioside A in mice, they have been attributed to the metabolites steviol and steviol glucuronide. We aimed to characterize the pharmacokinetic and pharmacodynamic properties of rebaudioside A and its metabolites in patients with early-onset type 2 diabetes mellitus (T2DM). Methods This randomized, placebo-controlled, open-label, two-way crossover trial was performed in subjects with T2DM on metformin or no therapy at the University Hospitals Leuven, Belgium. Following oral rebaudioside A (3 g), plasma concentrations of rebaudioside A, steviol and steviol glucuronide were determined. The effect on glucose homeostasis was examined by an oral glucose tolerance test (OGTT) performed 19 h following rebaudioside A administration, i.e. the presumed time of maximal steviol and steviol glucuronide concentrations. The primary pharmacodynamic endpoint was the difference in area under the blood glucose concentration-time curve during the first 2 h of the OGTT (AUC(Glucose(0-2h))) for rebaudioside A vs. placebo. Results In total, 30 subjects [63.5 (57.8-69.0) years of age, 86.7% male] completed the trial. Rebaudioside A was detected as early as 1 h after administration in nearly all subjects. As expected, steviol and steviol glucuronide reached their maximal concentrations at 19.5 h following rebaudioside A administration. Rebaudioside A did not lower the AUC(Glucose(0-2h)) compared to placebo (- 0.7 (95% CI - 22.3; 20.9) h center dot mg/dL, P = 0.95). Insulin and C-peptide concentrations were also comparable between both conditions (P > 0.05). Conclusion Rebaudioside A is readily absorbed after oral administration and metabolized to steviol and steviol glucuronide. However, no effect on glucose nor insulin or C-peptide excursion was observed during the OGTT at the time of maximal metabolite concentrations. Thus, no antidiabetic properties of rebaudioside A could be observed in patients with T2DM after single oral use.
C1 [Simoens, Caroline; Philippaert, Koenraad; Wuyts, Caroline; Vennekens, Rudi] Katholieke Univ Leuven, Lab Ion Channel Res, Dept Cellular & Mol Med, Leuven, Belgium.
   [Simoens, Caroline; Philippaert, Koenraad; Wuyts, Caroline; Vennekens, Rudi] VIB Ctr Brain & Dis Res, Leuven, Belgium.
   [Simoens, Caroline; Vangoitsenhoven, Roman; Mertens, Ann; Van der Schueren, Bart] Katholieke Univ Leuven, Dept Chron Dis & Metab, Clin & Expt Endocrinol, Leuven, Belgium.
   [Goscinny, Severine; Van Hoeck, Els; Van Loco, Joris] Sciensano, Chem & Phys Hlth Risks, Elsene, Belgium.
   [Billen, Jaak] Univ Hosp Leuven, Dept Lab Med, Leuven, Belgium.
   [de Hoon, Jan; Ampe, Els] Katholieke Univ Leuven, Dept Pharmaceut & Pharmacol Sci, Ctr Clin Pharmacol, Leuven, Belgium.
   [Vangoitsenhoven, Roman; Mertens, Ann; Van der Schueren, Bart] Univ Hosp Leuven, Dept Endocrinol, Leuven, Belgium.
C3 KU Leuven; Flanders Institute for Biotechnology (VIB); KU Leuven;
   Sciensano; KU Leuven; University Hospital Leuven; KU Leuven; KU Leuven;
   University Hospital Leuven
RP Van der Schueren, B (通讯作者)，Katholieke Univ Leuven, Dept Chron Dis & Metab, Clin & Expt Endocrinol, Leuven, Belgium.; Van der Schueren, B (通讯作者)，Univ Hosp Leuven, Dept Endocrinol, Leuven, Belgium.
EM caroline.simoens@kuleuven.be; koenraad.philippaert@gmail.com;
   caroline.wuyts@kuleuven.be; severine.goscinny@sciensano.be;
   els.vanhoeck@sciensano.be; joris.vanloco@sciensano.be;
   jaak.billen@kuleuven.be; jan.dehoon@kuleuven.be; els.ampe@uzleuven.be;
   roman.vangoitsenhoven@kuleuven.be; ann.mertens@kuleuven.be;
   rudi.vennekens@kuleuven.be; bart.vanderschueren@kuleuven.be
RI Vangoitsenhoven, Roman/B-3196-2018; vennekens, rudi/AHD-0495-2022
OI Vangoitsenhoven, Roman/0000-0003-3523-669X; vennekens,
   rudi/0000-0002-2564-5150; Van der Schueren, Bart/0000-0003-4754-784X;
   Philippaert, Koenraad/0000-0002-5861-2275; Van Hoeck,
   Els/0000-0002-1172-2338; Mertens, Ann/0000-0002-1649-4311; Simoens,
   Caroline/0000-0001-8446-052X; Billen, Jaak/0000-0003-4852-4340; Wuyts,
   Caroline/0000-0002-9526-1590
FU KU Leuven Grant (TRPLe: TRP Research Platform Leuven) [C14/17/091]; FWO
   Vlaanderen [G0C2420N, GOE0217N]
FX The study was funded by a KU Leuven Grant (TRPLe: TRP Research Platform
   Leuven -C14/17/091) and FWO Vlaanderen (G0C2420N and GOE0217N).
CR Aguilar F, 2010, EFSA J, V8, DOI 10.2903/j.efsa.2010.1537
   Anker CCB, 2019, NUTRIENTS, V11, DOI 10.3390/nu11091965
   [Anonymous], 2005, GUID IND EST MAX SAF, P1
   Barriocanal LA, 2008, REGUL TOXICOL PHARM, V51, P37, DOI 10.1016/j.yrtph.2008.02.006
   Chang JC, 2005, HORM METAB RES, V37, P610, DOI 10.1055/s-2005-870528
   Chen TH, 2005, PLANTA MED, V71, P108, DOI 10.1055/s-2005-837775
   Davies MJ, 2018, DIABETOLOGIA, V61, P2461, DOI [10.1007/s00125-018-4729-5, 10.2337/dci18-0033]
   European Commission, 2011, AM ANN 2 REG EC 1333
   FDA, 2012, GRAS NOT GRN 000395
   Gardana C, 2003, J AGR FOOD CHEM, V51, P6618, DOI 10.1021/jf0303619
   Geuns JMC, 2007, EXP BIOL MED, V232, P164
   Geuns JMC, 2006, J AGR FOOD CHEM, V54, P2794, DOI 10.1021/jf052693e
   Geuns JMC, 2003, FOOD CHEM TOXICOL, V41, P1599, DOI 10.1016/S0278-6915(03)00191-1
   Gregersen S, 2004, METABOLISM, V53, P73, DOI 10.1016/j.metabol.2003.07.013
   Gu Wenqian, 2019, Endocrinol Diabetes Metab, V2, pe00093, DOI 10.1002/edm2.93
   Guilbert A, 2019, SCI TOTAL ENVIRON, V649, P620, DOI 10.1016/j.scitotenv.2018.08.338
   Hutapea AM, 1997, J CLIN BIOCHEM NUTR, V23, P177
   Jeppesen PB, 2003, METABOLISM, V52, P372, DOI 10.1053/meta.2003.50058
   Jeppesen PB, 2002, PHYTOMEDICINE, V9, P9, DOI 10.1078/0944-7113-00081
   Jeppesen PB, 2000, METABOLISM, V49, P208, DOI 10.1016/S0026-0495(00)91325-8
   Kennelly EJ, 2002, STEVIA GENUS STEVIA, P68
   Koyama E, 2003, FOOD CHEM TOXICOL, V41, P875, DOI 10.1016/S0278-6915(03)00039-5
   Koyama E, 2003, FOOD CHEM TOXICOL, V41, P359, DOI 10.1016/S0278-6915(02)00235-1
   Maki KC, 2008, FOOD CHEM TOXICOL, V46, pS47, DOI 10.1016/j.fct.2008.05.007
   Myint KZ, 2020, J SCI FOOD AGR, V100, P3841, DOI 10.1002/jsfa.10421
   Nikiforov AI, 2013, INT J TOXICOL, V32, P261, DOI 10.1177/1091581813492828
   Onakpoya IJ, 2015, EUR J PREV CARDIOL, V22, P1575, DOI 10.1177/2047487314560663
   Philippaert K, 2017, NAT COMMUN, V8, DOI 10.1038/ncomms14733
   Roberts A, 2016, REGUL TOXICOL PHARM, V79, P91, DOI 10.1016/j.yrtph.2016.05.017
   Wheeler A, 2008, FOOD CHEM TOXICOL, V46, pS54, DOI 10.1016/j.fct.2008.04.041
   Zheng Y, 2018, NAT REV ENDOCRINOL, V14, P88, DOI 10.1038/nrendo.2017.151
NR 31
TC 0
Z9 0
U1 2
U2 4
PU SPRINGER FRANCE
PI PARIS
PA 22 RUE DE PALESTRO, PARIS, 75002, FRANCE
SN 0378-7966
EI 2107-0180
J9 EUR J DRUG METAB PH
JI Eur. J. Drug Metabol. Pharmacokinet.
PD NOV
PY 2022
VL 47
IS 6
BP 827
EP 839
DI 10.1007/s13318-022-00792-7
EA SEP 2022
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 5X6CG
UT WOS:000849462900001
PM 36057030
OA Green Accepted, Bronze, Green Published
DA 2023-06-08
ER

PT J
AU Gaucher, L
   Adda, L
   Sejourne, A
   Joachim, C
   Guillaume, C
   Poulet, C
   Liabeuf, S
   Gras-Champel, V
   Masmoudi, K
   Houessinon, A
   Bennis, Y
   Batteux, B
AF Gaucher, Louis
   Adda, Leslie
   Sejourne, Alice
   Joachim, Camille
   Guillaume, Chaby
   Poulet, Claire
   Liabeuf, Sophie
   Gras-Champel, Valerie
   Masmoudi, Kamel
   Houessinon, Aline
   Bennis, Youssef
   Batteux, Benjamin
TI Associations between dysbiosis-inducing drugs, overall survival and
   tumor response in patients treated with immune checkpoint inhibitors
SO THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
LA English
DT Article
DE antibiotic; drug-induced dysbiosis; dysbiosis; immune checkpoint
   inhibitor; melanoma
AB Background:
   There are conflicting data on the effects of dysbiosis-inducing drugs, and especially antibiotics (ATBs), on clinical outcomes in patients treated with immune checkpoint inhibitors (ICIs). There is a particular lack of data for patients with melanoma.
   Methods:
   We performed a single-center retrospective study of the associations between ATBs and other drugs known to modify the gut microbiota (proton pump inhibitors, nonsteroidal anti-inflammatory drugs, statins, opioids, anti-vitamin K, levothyroxine, vitamin D3, antiarrhythmics, metformin and phloroglucinol), overall survival (OS) and tumor response in consecutive cancer patients (particularly those with melanoma) treated with an ICI (ipilimumab, nivolumab or pembrolizumab) over a 9-year period.
   Results:
   A total of 372 patients were included. The mean +/- standard deviation age was 64.0 +/- 12.1 years. The most frequently prescribed ICI was nivolumab (in 58.3% of patients) and the most frequent indications were lung cancer (44.6%) and melanoma (29.6%). Overall, 112 patients (30.1%) had received ATBs. ATB use was associated with (1) shorter OS in the study population as a whole [adjusted hazard ratio [95% confidence interval (CI)]: 1.38 (1.00-1.90), p = 0.048] and in patients with melanoma [adjusted hazard ratio (95% CI): 2.60 (1.06-6.39), p = 0.037], and (2) a lower response rate in the study population as a whole [8.1%, versus 31.1% in patients not treated with ATBs; adjusted odds ratio (95% CI): 6.06 (2.80-14.53), p < 0.001] and in patients with melanoma [adjusted odds ratio (95% CI): 4.41 (1.04-22.80), p = 0.045]. Sensitivity analyses that minimized the indication bias did not reveal an association between OS and the presence of an infection requiring ATBs (quantified as the severity of infection, hospitalization for an infection, or ICI discontinuation). Other dysbiosis-inducing drugs were not associated with a difference in OS.
   Conclusion:
   Unlike other dysbiosis-inducing drugs, ATBs were associated with poorer clinical outcomes in ICI-treated patients overall and in the subset of patients with melanoma.
C1 [Gaucher, Louis; Adda, Leslie; Liabeuf, Sophie; Gras-Champel, Valerie; Masmoudi, Kamel; Bennis, Youssef; Batteux, Benjamin] Amiens Univ, Dept Clin Pharmacol, Med Ctr, Rue Prof Christian Cabrol, F-80000 Amiens, France.
   [Batteux, Benjamin] St Quentin Med Ctr, St Quentin en Yvelines, France.
   [Liabeuf, Sophie; Gras-Champel, Valerie; Bennis, Youssef; Batteux, Benjamin] Jules Verne Univ Picardie, MP3CV Lab, EA7517, Amiens, France.
   [Batteux, Benjamin] Amiens Univ, RECIF, Med Ctr, Amiens, France.
   [Sejourne, Alice] St Quentin Med Ctr, Dept Rheumatol, St Quentin en Yvelines, France.
   [Sejourne, Alice; Houessinon, Aline] Amiens Univ, Dept Oncol, Med Ctr, Amiens, France.
   [Joachim, Camille; Guillaume, Chaby] Amiens Univ, Dept Dermatol, Med Ctr, Amiens, France.
   [Poulet, Claire] Amiens Univ, Dept Pneumol, Med Ctr, Amiens, France.
C3 Picardie Universites; Universite de Picardie Jules Verne (UPJV); CHU
   Amiens; Picardie Universites; Universite de Picardie Jules Verne (UPJV);
   Picardie Universites; Universite de Picardie Jules Verne (UPJV); CHU
   Amiens; Picardie Universites; Universite de Picardie Jules Verne (UPJV);
   CHU Amiens; Picardie Universites; Universite de Picardie Jules Verne
   (UPJV); CHU Amiens; Picardie Universites; Universite de Picardie Jules
   Verne (UPJV); CHU Amiens
RP Batteux, B (通讯作者)，Amiens Univ, Dept Clin Pharmacol, Med Ctr, Rue Prof Christian Cabrol, F-80000 Amiens, France.; Batteux, B (通讯作者)，St Quentin Med Ctr, St Quentin en Yvelines, France.; Batteux, B (通讯作者)，Jules Verne Univ Picardie, MP3CV Lab, EA7517, Amiens, France.; Batteux, B (通讯作者)，Amiens Univ, RECIF, Med Ctr, Amiens, France.
EM batteux.benjamin@chu-amiens.fr
RI , liabeuf/AFB-7848-2022; LIABEUF, Sophie/CAH-7505-2022; Bennis,
   Youssef/F-3662-2015
OI Bennis, Youssef/0000-0002-0186-4797; Batteux,
   Benjamin/0000-0001-9466-7110
CR Acharya C, 2017, ALIMENT PHARM THER, V45, P319, DOI [10.1111/apt.13858, 10.1111/apt.14585]
   Afzal MZ, 2019, J CLIN ONCOL, V37, DOI 10.1200/JCO.2019.37.15_suppl.e21040
   Alsaab HO, 2017, FRONT PHARMACOL, V8, DOI 10.3389/fphar.2017.00561
   Arbour KC, 2018, J CLIN ONCOL, V36, P2872, DOI 10.1200/JCO.2018.79.0006
   Bartlett EK, 2015, SURG ONCOL CLIN N AM, V24, P215, DOI 10.1016/j.soc.2014.12.001
   Bruno G, 2019, WORLD J GASTROENTERO, V25, P2706, DOI 10.3748/wjg.v25.i22.2706
   Caparros-Martin JA, 2017, MICROBIOME, V5, DOI 10.1186/s40168-017-0312-4
   Chalabi M, 2020, ANN ONCOL, V31, P525, DOI [10.1016/j.annonc.2020.01.006, 10.1016/j.annoc.2020.01.006]
   CHARLSON ME, 1987, J CHRON DIS, V40, P373, DOI 10.1016/0021-9681(87)90171-8
   Charoenngam N, 2020, ANTICANCER RES, V40, P551, DOI 10.21873/anticanres.13984
   Chasset F, 2015, EUR J DERMATOL, V25, P36, DOI 10.1684/ejd.2014.2471
   Chen DS, 2017, NATURE, V541, P321, DOI 10.1038/nature21349
   Cussotto S, 2019, PSYCHOPHARMACOLOGY, V236, P1411, DOI 10.1007/s00213-019-5185-8
   Derosa L, 2018, ANN ONCOL, V29, P1437, DOI 10.1093/annonc/mdy103
   Dias AM, 2020, PHARMACOL RES PERSPE, V8, DOI 10.1002/prp2.601
   Eisenhauer EA, 2009, EUR J CANCER, V45, P228, DOI 10.1016/j.ejca.2008.10.026
   Failing JJ, 2016, MELANOMA RES, V26, P609, DOI 10.1097/CMR.0000000000000299
   Fakhoury HMA, 2020, J STEROID BIOCHEM, V200, DOI 10.1016/j.jsbmb.2020.105663
   Farrokhi AS, 2019, J CELL PHYSIOL, V234, P14941, DOI 10.1002/jcp.28333
   Freeman-Keller M, 2016, CLIN CANCER RES, V22, P886, DOI 10.1158/1078-0432.CCR-15-1136
   Gaboriau-Routhiau V, 2016, M S-MED SCI, V32, P961, DOI 10.1051/medsci/20163211011
   Hakozaki T, 2019, ONCOL LETT, V17, P2946, DOI 10.3892/ol.2019.9899
   Haslam A, 2019, JAMA NETW OPEN, V2, DOI 10.1001/jamanetworkopen.2019.2535
   Homicsko K, 2018, ANN ONCOL, V29, P40
   Hopkins AM, 2020, EUR UROL, V78, P540, DOI 10.1016/j.eururo.2020.06.061
   Hopkins AM, 2020, CLIN CANCER RES, V26, P5487, DOI 10.1158/1078-0432.CCR-20-1876
   Horvat TZ, 2015, J CLIN ONCOL, V33, P3193, DOI 10.1200/JCO.2015.60.8448
   Huemer Florian, 2018, Oncotarget, V9, P16512, DOI 10.18632/oncotarget.24751
   Humphries A, 2018, HUM VACC IMMUNOTHER, V14, P2178, DOI 10.1080/21645515.2018.1442970
   Iglesias-Santamaria A, 2020, CLIN TRANSL ONCOL, V22, P1481, DOI 10.1007/s12094-019-02282-w
   Imhann F, 2016, GUT, V65, P740, DOI 10.1136/gutjnl-2015-310376
   Inamura K, 2020, SEMIN CANCER BIOL, V65, P164, DOI 10.1016/j.semcancer.2019.12.026
   Jackson MA, 2016, GUT, V65, P749, DOI 10.1136/gutjnl-2015-310861
   Kaderbhai C, 2017, ANTICANCER RES, V37, P3195, DOI 10.21873/anticanres.11680
   Kapoor A., 2019, CANC RES STAT TREAT, V2, P204, DOI [10.4103/CRST.CRST_88_19, DOI 10.4103/CRST.CRST_88_19]
   Le Bastard Q, 2018, ALIMENT PHARM THER, V47, P332, DOI 10.1111/apt.14451
   Levy MM, 2003, CRIT CARE MED, V31, P1250, DOI 10.1097/01.CCM.0000050454.01978.3B
   Maier L, 2018, NATURE, V555, P623, DOI 10.1038/nature25979
   McDermott D, 2014, CANCER TREAT REV, V40, P1056, DOI 10.1016/j.ctrv.2014.06.012
   Okada N, 2019, CLIN THER, V41, P59, DOI 10.1016/j.clinthera.2018.11.004
   Pinato DJ, 2019, J IMMUNOTHER CANCER, V7, DOI 10.1186/s40425-019-0775-x
   Pollak M, 2017, DIABETOLOGIA, V60, P1662, DOI 10.1007/s00125-017-4352-x
   Ricciuti B, 2019, J CLIN ONCOL, V37, P1927, DOI 10.1200/JCO.19.00189
   Rodriguez-Cerdeira C, 2017, MEDIAT INFLAMM, V2017, DOI 10.1155/2017/3264217
   Rogers MAM, 2016, CLIN MICROBIOL INFEC, V22, DOI 10.1016/j.cmi.2015.10.003
   Routy B, 2018, SCIENCE, V359, P91, DOI 10.1126/science.aan3706
   Ruiz-Patino A, 2020, THORAC CANCER, V11, P353, DOI 10.1111/1759-7714.13272
   Scott SC, 2018, J THORAC ONCOL, V13, P1771, DOI 10.1016/j.jtho.2018.06.004
   Sivan A, 2015, SCIENCE, V350, P1084, DOI 10.1126/science.aac4255
   Tamanai-Shacoori Z, 2007, ANESTH ANALG, V105, P524, DOI 10.1213/01.ane.0000267525.51017.b8
   Teulings HE, 2015, J CLIN ONCOL, V33, P773, DOI 10.1200/JCO.2014.57.4756
   Tinsley N, 2020, ONCOLOGIST, V25, P55, DOI 10.1634/theoncologist.2019-0160
   Ueda K, 2019, ANTICANCER RES, V39, P6265, DOI 10.21873/anticanres.13836
   Vetizou M, 2015, SCIENCE, V350, P1079, DOI 10.1126/science.aad1329
   Vivarelli S, 2019, CANCERS, V11, DOI 10.3390/cancers11010038
   Weber JS., 2017, J CLIN ONCOL, V35, P9523
   Wolchok JD, 2008, ONCOLOGIST, V13, P2, DOI 10.1634/theoncologist.13-S4-2
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Zimmermann P, 2019, J INFECTION, V79, P471, DOI 10.1016/j.jinf.2019.10.008
NR 59
TC 17
Z9 17
U1 0
U2 1
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1758-8340
EI 1758-8359
J9 THER ADV MED ONCOL
JI Ther. Adv. Med. Oncol.
PD MAR
PY 2021
VL 13
AR 17588359211000591
DI 10.1177/17588359211000591
PG 23
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA QX4ZH
UT WOS:000629355900001
PM 33796151
OA Green Published, gold
DA 2023-06-08
ER

PT J
AU Xie, XH
   Liao, JB
   Ai, YL
   Gao, JM
   Zhao, J
   Qu, F
   Xu, C
   Zhang, ZY
   Wen, WB
   Cui, HT
   Wang, HW
AF Xie, Xuehua
   Liao, Jiabao
   Ai, Yuanliang
   Gao, Jinmei
   Zhao, Jie
   Qu, Fei
   Xu, Chao
   Zhang, Zhaiyi
   Wen, Weibo
   Cui, Huantian
   Wang, Hongwu
TI Pi-Dan-Jian-Qing Decoction Ameliorates Type 2 Diabetes Mellitus Through
   Regulating the Gut Microbiota and Serum Metabolism
SO FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
LA English
DT Article
DE type 2 diabetes mellitus; Pi-Dan-Jian-Qing decoction; gut microbiota;
   tryptophan metabolism; histamine metabolism; TCA cycle
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; HISTIDINE; CELLS; INFLAMMATION;
   MANAGEMENT; CARNOSINE; METFORMIN; DISEASE
AB Pi-Dan-Jian-Qing decoction (PDJQ) can been used in the treatment of type 2 diabetes mellitus (T2DM) in clinic. However, the protective mechanisms of PDJQ on T2DM remain unknown. Recent studies have shown that the changes in gut microbiota could affect the host metabolism and contribute to progression of T2DM. In this study, we first investigated the therapeutic effects of PDJQ on T2DM rats. 16S rRNA sequencing and untargeted metabolomics analyses were used to investigate the mechanisms of action of PDJQ in the treatment of T2DM. Our results showed that PDJQ treatment could improve the hyperglycemia, hyperlipidemia, insulin resistance (IR) and pathological changes of liver, pancreas, kidney, and colon in T2DM rats. PDJQ could also decrease the levels of pro-inflammatory cytokines and inhibit the oxidative stress. 16S rRNA sequencing showed that PDJQ could decrease the Firmicutes/Bacteroidetes (F to B) ratio at the phylum level. At the genus level, PDJQ could increase the relative abundances of Lactobacillus, Blautia, Bacteroides, Desulfovibrio and Akkermansia and decrease the relative abundance of Prevotella. Serum untargeted metabolomics analysis showed that PDJQ could regulate tryptophan metabolism, histidine metabolism, tricarboxylic acid (TCA) cycle, phenylalanine, tyrosine and tryptophan biosynthesis and tyrosine metabolism pathways. Correlation analysis indicated that the modulatory effects of PDJQ on the tryptophan metabolism, histidine metabolism and TCA cycle pathways were related to alterations in the abundance of Lactobacillus, Bacteroides and Akkermansia. In conclusion, our study revealed the various ameliorative effects of PDJQ on T2DM, including improving the liver and kidney functions and alleviating the hyperglycemia, hyperlipidemia, IR, pathological changes, oxidative stress and inflammatory response. The mechanisms of PDJQ on T2DM are likely linked to an improvement in the dysbiosis of gut microbiota and modulation of tryptophan metabolism, histamine metabolism, and the TCA cycle.
C1 [Xie, Xuehua] Nanjing Univ Tradit Chinese Med, Coll Clin Med 1, Nanjing, Jiangsu, Peoples R China.
   [Xie, Xuehua; Zhao, Jie; Xu, Chao; Wen, Weibo] Yunnan Prov Hosp Chinese Med, Dept Endocrinol, Kunming, Yunnan, Peoples R China.
   [Liao, Jiabao; Qu, Fei] Jiaxing Hosp Tradit Chinese Med, Dept Emergency, Jiaxing, Zhejiang, Peoples R China.
   [Liao, Jiabao] Jiaxing Hosp Tradit Chinese Med, Jiaxing Key Lab Diabet Angiopathy Res, Jiaxing, Zhejiang, Peoples R China.
   [Ai, Yuanliang] Kunming Municipal Hosp Tradit Chinese Med, Dept Orthped, Kunming, Yunnan, Peoples R China.
   [Gao, Jinmei] Fujian Peoples Hosp Tradit Chinese Med, Dept Rehabil, Fuzhou, Fujian, Peoples R China.
   [Zhang, Zhaiyi] Tianjin Univ Tradit Chinese Med, Coll Integrated Chinese & Western Med, Tianjin, Peoples R China.
   [Cui, Huantian] Shandong Univ, Sch Life Sciences, Shandong Prov Key Lab Anim Cell & Dev Biol, Jinan, Shandong, Peoples R China.
   [Wang, Hongwu] Tianjin Univ Tradit Chinese Med, Coll Tradit Chinese Med, Tianjin, Peoples R China.
C3 Nanjing University of Chinese Medicine; Tianjin University of
   Traditional Chinese Medicine; Shandong University; Tianjin University of
   Traditional Chinese Medicine
RP Wen, WB (通讯作者)，Yunnan Prov Hosp Chinese Med, Dept Endocrinol, Kunming, Yunnan, Peoples R China.; Cui, HT (通讯作者)，Shandong Univ, Sch Life Sciences, Shandong Prov Key Lab Anim Cell & Dev Biol, Jinan, Shandong, Peoples R China.; Wang, HW (通讯作者)，Tianjin Univ Tradit Chinese Med, Coll Tradit Chinese Med, Tianjin, Peoples R China.
EM wenweibo2020@163.com; 1762316411@qq.com; whw2009@tjutcm.edu.cn
RI Cui, Huantian/AAS-4283-2021; wang, hw/HZH-3227-2023
FU National Science Foundation of China [82104802]; Science and Technology
   Projects of Yunnan Province [202101AT070246]; Key scientific project of
   Yunnan province [2019ZF005]
FX Funding This work was supported by National Science Foundation of China
   (No. 82104802); Science and Technology Projects of Yunnan Province (No.
   202101AT070246); Key scientific project of Yunnan province (No.
   2019ZF005).
CR Baek SM, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-73994-1
   Brandacher G, 2006, OBES SURG, V16, P541, DOI 10.1381/096089206776945066
   Chavez-Carbajal A, 2020, MICROORGANISMS, V8, DOI 10.3390/microorganisms8010094
   Chen LL, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0115708
   Chen MY, 2020, INT J BIOL MACROMOL, V155, P890, DOI 10.1016/j.ijbiomac.2019.11.047
   Chen MY, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.02380
   Chen SK, 2013, INT J MOL SCI, V14, P19399, DOI 10.3390/ijms141019399
   Chen TL, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0162192
   Cheung SG, 2019, FRONT PSYCHIATRY, V10, DOI 10.3389/fpsyt.2019.00034
   Choi I, 2021, LIFE-BASEL, V11, DOI 10.3390/life11010069
   Dai JR, 2011, CYTOTECHNOLOGY, V63, P599, DOI 10.1007/s10616-011-9381-6
   Dai WD, 2017, FOOD RES INT, V96, P40, DOI 10.1016/j.foodres.2017.03.028
   Dayer M R, 2009, Pak J Biol Sci, V12, P1025, DOI 10.3923/pjbs.2009.1025.1030
   Ding XQ, 2019, BIOMED PHARMACOTHER, V110, P85, DOI 10.1016/j.biopha.2018.11.018
   Douzi W, 2020, METABOLITES, V10, DOI 10.3390/metabo10110460
   Edgar RC, 2004, NUCLEIC ACIDS RES, V32, P1792, DOI 10.1093/nar/gkh340
   Edgar RC, 2013, NAT METHODS, V10, P996, DOI [10.1038/nmeth.2604, 10.1038/NMETH.2604]
   Fan YB, 2018, BIOMED PHARMACOTHER, V106, P733, DOI 10.1016/j.biopha.2018.06.089
   Feng RN, 2013, DIABETOLOGIA, V56, P985, DOI 10.1007/s00125-013-2839-7
   Gao Z, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-35706-8
   Huang S, 2014, J DIABETES RES, V2014, DOI 10.1155/2014/717219
   Huda MN, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.632335
   Iacobazzi V, 2014, BIOL CHEM, V395, P387, DOI 10.1515/hsz-2013-0271
   Inzucchi SE, 2012, DIABETES CARE, V35, P1364, DOI 10.2337/dc12-0413
   Jasirwan COM, 2021, BIOSCI MICROB FOOD H, V40, P50, DOI 10.12938/bmfh.2020-046
   Jenq RR, 2015, BIOL BLOOD MARROW TR, V21, P1373, DOI 10.1016/j.bbmt.2015.04.016
   Kartika R, 2020, INT J TRYPTOPHAN RES, V13, DOI 10.1177/1178646920978236
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Lee YT, 2005, EUR J PHARMACOL, V513, P145, DOI 10.1016/j.ejphar.2005.02.010
   Liu JL, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21030910
   Liu WH, 2008, FOOD CHEM TOXICOL, V46, P1503, DOI 10.1016/j.fct.2007.12.013
   Magoc T, 2011, BIOINFORMATICS, V27, P2957, DOI 10.1093/bioinformatics/btr507
   Morshedi M, 2020, J TRANSL MED, V18, DOI 10.1186/s12967-019-02169-y
   Munhoz AC, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0158166
   Ortega MA, 2020, NUTRIENTS, V12, DOI 10.3390/nu12092749
   Pang B, 2017, DIABETES RES CLIN PR, V131, P242, DOI 10.1016/j.diabres.2017.07.020
   Qiao SS, 2020, CELL REP, V32, DOI 10.1016/j.celrep.2020.108005
   Quast C, 2013, NUCLEIC ACIDS RES, V41, pD590, DOI 10.1093/nar/gks1219
   Rivera-Mancia S, 2015, EUR J PHARMACOL, V756, P30, DOI 10.1016/j.ejphar.2015.02.045
   Rotter V, 2003, J BIOL CHEM, V278, P45777, DOI 10.1074/jbc.M301977200
   Said E, 2021, J ADV RES, V28, P27, DOI 10.1016/j.jare.2020.06.013
   Senn JJ, 2002, DIABETES, V51, P3391, DOI 10.2337/diabetes.51.12.3391
   Shao J, 2020, OXID MED CELL LONGEV, V2020, DOI 10.1155/2020/1805418
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Stojanov S, 2020, MICROORGANISMS, V8, DOI 10.3390/microorganisms8111715
   Tanase DM, 2020, NUTRIENTS, V12, DOI 10.3390/nu12123719
   Tsai JC, 2019, MOLECULES, V24, DOI 10.3390/molecules24061112
   Vera-Aviles M, 2018, PHARMACEUTICALS-BASE, V11, DOI 10.3390/ph11040111
   Wake H, 2020, FREE RADICAL RES, V54, P649, DOI 10.1080/10715762.2020.1825703
   Wang YW, 2021, NAT COMMUN, V12, DOI 10.1038/s41467-020-20315-9
   Watanabe M, 2008, AM J CLIN NUTR, V87, P1860, DOI 10.1093/ajcn/87.6.1860
   Xia F, 2021, WORLD J DIABETES, V12, P1146, DOI 10.4239/wjd.v12.i8.1146
   Xie XH., 2021, TMR PHARM, V1, P23, DOI [10.53388/tmrpr20211009023, DOI 10.53388/TMRPR20211009023]
   Yanagisawa M, 2006, CURR MICROBIOL, V52, P375, DOI 10.1007/s00284-005-0261-1
   Yang CM, 2010, J CELL PHYSIOL, V224, P516, DOI 10.1002/jcp.22153
   Yang L, 2020, BIOLOGY-BASEL, V9, DOI 10.3390/biology9080203
   Yang ZD, 2021, MOLECULES, V26, DOI 10.3390/molecules26092464
   Yaribeygi H, 2020, OXID MED CELL LONGEV, V2020, DOI 10.1155/2020/8609213
   Yu B, 2015, CIRC-CARDIOVASC GENE, V8, P351, DOI 10.1161/CIRCGENETICS.114.000697
   Zhang Q, 2020, DIABET METAB SYND OB, V13, P5003, DOI 10.2147/DMSO.S286430
   Zheng L, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms7001
   Zhou W, 2018, CELL BIOL INT, V42, P1282, DOI 10.1002/cbin.11015
NR 62
TC 9
Z9 10
U1 7
U2 29
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2235-2988
J9 FRONT CELL INFECT MI
JI Front. Cell. Infect. Microbiol.
PD DEC 6
PY 2021
VL 11
AR 748872
DI 10.3389/fcimb.2021.748872
PG 16
WC Immunology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Microbiology
GA XR1LY
UT WOS:000732001100001
PM 34938667
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Hasain, Z
   Ali, RAR
   Ahmad, HF
   Rauf, UFA
   Oon, SF
   Mokhtar, NM
AF Hasain, Zubaidah
   Raja Ali, Raja Affendi
   Ahmad, Hajar Fauzan
   Abdul Rauf, Ummul Fahri
   Oon, Seok Fang
   Mokhtar, Norfilza Mohd
TI The Roles of Probiotics in the Gut Microbiota Composition and Metabolic
   Outcomes in Asymptomatic Post-Gestational Diabetes Women: A Randomized
   Controlled Trial
SO NUTRIENTS
LA English
DT Article
DE gestational diabetes; gut microbiota; insulin resistance; probiotic;
   glycemic control; inflammation
ID GLYCEMIC CONTROL; DOUBLE-BLIND; HIGH-FAT; MELLITUS; INTERVENTION;
   MANAGEMENT; METFORMIN; HISTORY; RISK
AB Probiotics are widely used as an adjuvant therapy in various diseases. Nonetheless, it is uncertain how they affect the gut microbiota composition and metabolic and inflammatory outcomes in women who have recently experienced gestational diabetes mellitus (post-GDM). A randomized, double-blind, placebo-controlled clinical trial involving 132 asymptomatic post-GDM women was conducted to close this gap (Clinical Trial Registration: NCT05273073). The intervention (probiotics) group received a cocktail of six probiotic strains from Bifidobacterium and Lactobacillus for 12 weeks, while the placebo group received an identical sachet devoid of living microorganisms. Anthropometric measurements, biochemical analyses, and 16S rRNA gene sequencing results were evaluated pre- and post-intervention. After the 12-week intervention, the probiotics group's fasting blood glucose level significantly decreased (mean difference -0.20 mmol/L; p = 0.0021). The HbA1c, total cholesterol, triglycerides, and high-sensitivity C-reactive protein levels were significantly different between the two groups (p < 0.05). Sequencing data also demonstrated a large rise in the Bifidobacterium adolescentis following probiotic supplementation. Our findings suggest that multi-strain probiotics are beneficial for improved metabolic and inflammatory outcomes in post-GDM women by modulating gut dysbiosis. This study emphasizes the necessity for a comprehensive strategy for postpartum treatment that includes probiotics to protect post-GDM women from developing glucose intolerance.
C1 [Hasain, Zubaidah; Mokhtar, Norfilza Mohd] Univ Kebangsaan Malaysia, Fac Med, Dept Physiol, Kuala Lumpur 56000, Malaysia.
   [Hasain, Zubaidah] Univ Pertahanan Nasl Malaysia, Fac Med & Def Hlth, Unit Physiol, Kuala Lumpur 57000, Malaysia.
   [Raja Ali, Raja Affendi] Univ Kebangsaan Malaysia, Fac Med, Dept Med, Gastroenterol Unit, Kuala Lumpur 56000, Malaysia.
   [Raja Ali, Raja Affendi; Mokhtar, Norfilza Mohd] Univ Kebangsaan Malaysia, Fac Med, GUT Res Grp, Kuala Lumpur 56000, Malaysia.
   [Ahmad, Hajar Fauzan] Univ Malaysia Pahang, Fac Ind Sci & Technol, Dept Ind Biotechnol, Gambang 26300, Malaysia.
   [Ahmad, Hajar Fauzan] Univ Malaysia Pahang, Ctr Res Adv Trop Biosci, Gambang 26300, Malaysia.
   [Abdul Rauf, Ummul Fahri] Univ Pertahanan Nasl Malaysia, Ctr Fdn Studies, Dept Math, Kuala Lumpur 56000, Malaysia.
   [Oon, Seok Fang] B Crobes Lab Sdn Bhd, Perak 31400, Malaysia.
C3 Universiti Kebangsaan Malaysia; Universiti Pertahanan Nasional Malaysia;
   Universiti Kebangsaan Malaysia; Universiti Kebangsaan Malaysia;
   Universiti Malaysia Pahang; Universiti Malaysia Pahang; Universiti
   Pertahanan Nasional Malaysia
RP Mokhtar, NM (通讯作者)，Univ Kebangsaan Malaysia, Fac Med, Dept Physiol, Kuala Lumpur 56000, Malaysia.; Mokhtar, NM (通讯作者)，Univ Kebangsaan Malaysia, Fac Med, GUT Res Grp, Kuala Lumpur 56000, Malaysia.
EM norfilza@ppukm.ukm.edu.my
RI Ahmad, Hajar Fauzan/AAH-9911-2019; Hasain, Zubaidah/HHD-1313-2022;
   Mokhtar, Norfilza/AAK-8196-2020
OI Ahmad, Hajar Fauzan/0000-0003-2985-2496; Oon, Seok
   Fang/0000-0001-6589-3602; Mokhtar, Norfilza/0000-0002-4863-100X
FU Faculty of Medicine, Universiti Kebangsaan Malaysia [FF-2019-064/1];
   Universiti Pertahanan Nasional Malaysia (UPNM); B-Crobes Laboratory Sdn.
   Bhd.
FX This research was funded by a matching grant from the Faculty of
   Medicine, Universiti Kebangsaan Malaysia (FF-2019-064/1) and in
   collaboration with B-Crobes Laboratory Sdn. Bhd. The publication fee was
   jointly funded by the Faculty of Medicine, Universiti Kebangsaan
   Malaysia, and Universiti Pertahanan Nasional Malaysia (UPNM).
CR Amer Diabet Assoc, 2021, DIABETES CARE, V44, pS200, DOI 10.2337/dc21-S014
   Amer Diabet Assoc, 2021, DIABETES CARE, V44, pS15, DOI 10.2337/dc21-S002
   [Anonymous], 2019, IDF DIABETES ATLAS
   Ardeshirlarijani E, 2019, DARU, V27, P827, DOI 10.1007/s40199-019-00302-2
   Aroda VR, 2015, J CLIN ENDOCR METAB, V100, P1646, DOI 10.1210/jc.2014-3761
   Babadi M, 2019, PROBIOTICS ANTIMICRO, V11, P1227, DOI 10.1007/s12602-018-9490-z
   Badehnoosh B, 2018, J MATERN-FETAL NEO M, V31, P1128, DOI 10.1080/14767058.2017.1310193
   Bell A, 2021, GLYCOBIOLOGY, V31, P691, DOI 10.1093/glycob/cwaa097
   Bellamy L, 2009, LANCET, V373, P1773, DOI 10.1016/S0140-6736(09)60731-5
   Benhalima K, 2019, J CLIN MED, V8, DOI 10.3390/jcm8030383
   Borsini A, 2020, INT J NEUROPSYCHOPH, V23, P738, DOI 10.1093/ijnp/pyaa055
   Briliute J, 2019, NAT MICROBIOL, V4, P1571, DOI 10.1038/s41564-019-0466-x
   Buchanan TA, 2012, NAT REV ENDOCRINOL, V8, P639, DOI 10.1038/nrendo.2012.96
   Buelo AK, 2019, PREV MED REP, V14, DOI 10.1016/j.pmedr.2019.100877
   Chen P, 2014, J FUNCT FOODS, V10, P318, DOI 10.1016/j.jff.2014.06.014
   Chen Y, 2020, MED CLIN-BARCELONA, V154, P199, DOI 10.1016/j.medcli.2019.05.041
   Chong J, 2020, NAT PROTOC, V15, P799, DOI 10.1038/s41596-019-0264-1
   Crusell MKW, 2018, MICROBIOME, V6, DOI 10.1186/s40168-018-0472-x
   Davidson MB, 2020, DIABETES CARE, V43, P1983, DOI 10.2337/dc19-2221
   Di Lorenzo F, 2020, ACS CENTRAL SCI, V6, P1602, DOI 10.1021/acscentsci.0c00791
   Dolatkhah N, 2015, J HEALTH POPUL NUTR, V33, DOI 10.1186/s41043-015-0034-9
   Douglas GM, 2020, NAT BIOTECHNOL, V38, P685, DOI 10.1038/s41587-020-0548-6
   Ferrocino I, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-30735-9
   Firouzi S, 2017, EUR J NUTR, V56, P1535, DOI 10.1007/s00394-016-1199-8
   Fugmann M, 2015, SCI REP-UK, V5, DOI 10.1038/srep13212
   Gomes AC, 2014, NUTR J, V13, DOI 10.1186/1475-2891-13-60
   Guo J, 2016, J WOMENS HEALTH, V25, P38, DOI 10.1089/jwh.2015.5262
   Hajifaraji M, 2018, ASIA PAC J CLIN NUTR, V27, P581, DOI 10.6133/apjcn.082017.03
   Halkjaer SI, 2020, CURR DEV NUTR, V4, DOI 10.1093/cdn/nzaa095
   Hasain Z, 2021, NUTRIENTS, V13, DOI 10.3390/nu13093045
   Hasain Z, 2021, FRONT MICROBIOL, V12, DOI 10.3389/fmicb.2021.680622
   Hasain Z, 2020, FRONT CELL INFECT MI, V10, DOI 10.3389/fcimb.2020.00188
   Hasan S, 2018, ACTA OBSTET GYN SCAN, V97, P38, DOI 10.1111/aogs.13252
   Hashimoto Y, 2020, J DIABETES INVEST, V11, P1623, DOI 10.1111/jdi.13293
   Ida S, 2017, DIABETOLOGIA, V60, P1761, DOI 10.1007/s00125-017-4327-y
   Molli AEI, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-66751-x
   Jafarnejad S, 2016, J NUTR METAB, V2016, DOI 10.1155/2016/5190846
   Jamilian M, 2019, CLIN NUTR, V38, P2098, DOI 10.1016/j.clnu.2018.10.028
   Jiang JC, 2020, J FUNCT FOODS, V74, DOI 10.1016/j.jff.2020.104177
   Kamath DY, 2015, INDIAN J MED RES, V142, P261, DOI 10.4103/0971-5916.166582
   Karamali M, 2016, DIABETES METAB, V42, P234, DOI 10.1016/j.diabet.2016.04.009
   Kassaian N, 2019, DIABETES METAB SYND, V13, P2991, DOI 10.1016/j.dsx.2018.07.016
   Kassaian N, 2018, ACTA DIABETOL, V55, P1019, DOI 10.1007/s00592-018-1175-2
   Kijmanawat A, 2019, J DIABETES INVEST, V10, P163, DOI 10.1111/jdi.12863
   Kim C, 2014, DIABETIC MED, V31, P292, DOI 10.1111/dme.12382
   Kocsis T, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-68440-1
   Kong C, 2019, NUTRITION, V60, P175, DOI 10.1016/j.nut.2018.10.002
   Krueger Kem P, 2003, J Am Pharm Assoc (2003), V43, P668, DOI 10.1331/154434503322642598
   Kuang YS, 2017, GIGASCIENCE, V6, DOI 10.1093/gigascience/gix058
   Laitinen K, 2009, BRIT J NUTR, V101, P1679, DOI 10.1017/S0007114508111461
   Lakens D, 2013, FRONT PSYCHOL, V4, DOI 10.3389/fpsyg.2013.00863
   Larsen MP, 2017, J DIABETES RES, V2017, DOI 10.1155/2017/7583506
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Le Chatelier E, 2013, NATURE, V500, P541, DOI 10.1038/nature12506
   Lee CH, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0163424
   Lindsay KL, 2015, AM J OBSTET GYNECOL, V212, DOI 10.1016/j.ajog.2015.02.008
   Lindsay KL, 2014, INT J GYNECOL OBSTET, V125, P279, DOI 10.1016/j.ijgo.2014.01.004
   Maity C, 2021, J DIET SUPPL, V18, P577, DOI 10.1080/19390211.2020.1814931
   Ministry of Health Malaysia, 2015, CPG MANAGEMENT TYPE, V5th
   Mirza S, 2012, CYTOKINE, V57, P136, DOI 10.1016/j.cyto.2011.09.029
   Mohd Yusoff Z., 2018, SHS WEB C, V45, P05002, DOI [10.1051/shsconf/20184505002, DOI 10.1051/SHSCONF/20184505002]
   Moher D, 2010, BMJ-BRIT MED J, V340, DOI 10.1136/bmj.c869
   Morisset AS, 2011, ACTA OBSTET GYN SCAN, V90, P524, DOI 10.1111/j.1600-0412.2011.01094.x
   Nor MHM, 2021, NUTRIENTS, V13, DOI 10.3390/nu13093192
   Panwar H, 2013, DIABETES-METAB RES, V29, P103, DOI 10.1002/dmrr.2376
   Probiotics and Prebiotics|World Gastroenterology Organisation, US
   Quast C, 2013, NUCLEIC ACIDS RES, V41, pD590, DOI 10.1093/nar/gks1219
   Rayanagoudar G, 2016, DIABETOLOGIA, V59, P1403, DOI 10.1007/s00125-016-3927-2
   Razee H, 2010, HEALTH PROMOT J AUST, V21, P130, DOI 10.1071/HE10130
   Said EA, 2021, J MED VIROL, V93, P3915, DOI 10.1002/jmv.26654
   Sato J, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-12535-9
   Stein SA, 2013, EXPERT OPIN DRUG SAF, V12, P153, DOI 10.1517/14740338.2013.752813
   Swanson KS, 2020, NAT REV GASTRO HEPAT, V17, P687, DOI 10.1038/s41575-020-0344-2
   Tanase DM, 2020, NUTRIENTS, V12, DOI 10.3390/nu12123719
   Tarry-Adkins JL, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-88650-5
   Tonucci LB, 2017, CLIN NUTR, V36, P85, DOI 10.1016/j.clnu.2015.11.011
   Vounzoulaki E, 2020, BMJ-BRIT MED J, V369, DOI 10.1136/bmj.m1361
   Zaharuddin L, 2019, BMC GASTROENTEROL, V19, DOI 10.1186/s12876-019-1047-4
   Zhang JY, 2019, J DIABETES RES, V2019, DOI 10.1155/2019/5364730
   Zheng QX, 2021, J MICROBIOL, V59, P827, DOI 10.1007/s12275-021-1094-8
NR 80
TC 2
Z9 2
U1 3
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD SEP
PY 2022
VL 14
IS 18
AR 3878
DI 10.3390/nu14183878
PG 24
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 4R7VX
UT WOS:000856967700001
PM 36145254
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Meng, QH
   Xu, YD
   Li, Y
   Wang, YW
AF Meng, Qinghao
   Xu, Yidong
   Li, Ying
   Wang, Yiwen
TI Novel studies on Drosophila melanogaster model reveal the roles of
   JNK-Jak/STAT axis and intestinal microbiota in insulin resistance
SO JOURNAL OF DRUG TARGETING
LA English
DT Review
DE Drosophila melanogaster; Type 2 diabetes mellitus; Insulin resistance;
   JNK pathway; Intestinal microbiota
ID INNATE IMMUNE HOMEOSTASIS; ADIPOSE-TISSUE; HIGH-FAT; OBESITY;
   INFLAMMATION; CELLS; SUGAR; MECHANISMS; METFORMIN; RECEPTOR
AB The JNK pathway play a critical role in insulin resistance induced by a long-term high-sugar diet. However, the roles of up- and downstream molecules of the JNK pathway in insulin resistance are less known in vertebrates and invertebrates. As a classical organism in biological research, Drosophila melanogaster (D. melanogaster) has been widely applied to the studies of mechanism of insulin resistance. Based on previous studies, we found a novel predictive mechanism of the formation of insulin resistance in D. melanogaster. We found that JNK activated by high-sugar diet and dysregulated intestinal microbiota could mediate inflammation, and then the activated JNK released Upd3, which in turn stimulated Jak/STAT pathway to release ImpL2. ImpL2 can compete with Drosophila insulin-like peptides (Dilps) for binding with the insulin receptor and inhibit the activation of insulin pathway. In this study, we reviewed novel studies on the insulin signalling pathway based on the D. melanogaster model. The findings support our hypothesis. We, therefore, described how a long-term high-sugar diet disrupts intestinal microbiota to induce inflammation and the disruption of JNK-Jak/STAT axis. This description may offer some new clues to the formation of insulin resistance.
C1 [Meng, Qinghao; Xu, Yidong; Li, Ying; Wang, Yiwen] Tianjin Univ, Sch Pharmaceut Sci & Technol, Tianjin, Peoples R China.
C3 Tianjin University
RP Wang, YW (通讯作者)，Tianjin Univ, Sch Pharmaceut Sci & Technol, Tianjin, Peoples R China.
EM yiwen.wang@tju.edu.cn
RI Meng, Qinghao/GPX-4444-2022
OI Meng, Qinghao/0000-0001-7659-435X
FU Tianjin Research Innovation Project for Postgraduate Students
FX This work was supported by Tianjin Research Innovation Project for
   Postgraduate Students.
CR Alfa RW, 2016, DIS MODEL MECH, V9, P365, DOI 10.1242/dmm.023887
   Alfa RW, 2015, CELL METAB, V21, P323, DOI 10.1016/j.cmet.2015.01.006
   Arbouzova NI, 2006, DEVELOPMENT, V133, P2605, DOI 10.1242/dev.02411
   Baker KD, 2007, CELL METAB, V6, P257, DOI 10.1016/j.cmet.2007.09.002
   Bako HY, 2019, LIFE SCI, V239, DOI 10.1016/j.lfs.2019.117045
   Bayliak MM, 2019, COMP BIOCHEM PHYS A, V228, P18, DOI 10.1016/j.cbpa.2018.09.027
   Bischoff V, 2004, NAT IMMUNOL, V5, P1175, DOI 10.1038/ni1123
   Cangoz S, 2013, J CLIN PHARM THER, V38, P350, DOI 10.1111/jcpt.12077
   Charroux B, 2010, FLY, V4, P40, DOI 10.4161/fly.4.1.10810
   Chen L-W., 2014, AM ASS IMMNOL, V192, P133
   Chevee V, 2019, MICROB PATHOGENESIS, V136, DOI 10.1016/j.micpath.2019.103664
   Chimnaronk S, 2015, BMC STRUCT BIOL, V15, DOI 10.1186/s12900-015-0045-1
   CLISSOLD SP, 1988, DRUGS, V35, P214, DOI 10.2165/00003495-198835030-00003
   Deng J, 2018, J CELL MOL MED, V22, P546, DOI 10.1111/jcmm.13342
   Di Meo S, 2017, J ENDOCRINOL, V233, pR15, DOI 10.1530/JOE-16-0598
   Ding GM, 2021, CELL REP, V36, DOI 10.1016/j.celrep.2021.109553
   Dongre Utpal Jagdish, 2021, Biosciences Biotechnology Research Asia, V18, P357, DOI 10.13005/bbra/2922
   Dus M, 2013, NAT NEUROSCI, V16, P526, DOI 10.1038/nn.3372
   El-Kenawi A, 2017, CANCER CELL, V32, P727, DOI 10.1016/j.ccell.2017.11.015
   Figueroa-Clarevega A, 2015, DEV CELL, V33, P47, DOI 10.1016/j.devcel.2015.03.001
   Foley KP, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-018-07146-5
   Gao WW, 2018, J CELL MOL MED, V22, P3408, DOI 10.1111/jcmm.13617
   Geminard C, 2009, CELL METAB, V10, P199, DOI 10.1016/j.cmet.2009.08.002
   Gobert V, 2003, SCIENCE, V302, P2126, DOI 10.1126/science.1085432
   Goldstein BJ, 2002, AM J CARDIOL, V90, p3G
   Griffith B, 2009, ANTIOXID REDOX SIGN, V11, P2505, DOI [10.1089/ars.2009.2599, 10.1089/ARS.2009.2599]
   Guo SD, 2014, J ENDOCRINOL, V220, pT1, DOI 10.1530/JOE-13-0327
   Gupta D, 2008, CELL HOST MICROBE, V3, P273, DOI 10.1016/j.chom.2008.04.006
   HAKIM J, 1993, CR SOC BIOL, V187, P286
   Hay N, 2011, BBA-MOL CELL RES, V1813, P1965, DOI 10.1016/j.bbamcr.2011.03.013
   Hedengren M, 1999, MOL CELL, V4, P827, DOI 10.1016/S1097-2765(00)80392-5
   Hirosumi J, 2002, NATURE, V420, P333, DOI 10.1038/nature01137
   Holman RR, 1999, DIABETES CARE, V22, P960, DOI 10.2337/diacare.22.6.960
   Honegger Basil, 2008, J Biol, V7, P10, DOI 10.1186/jbiol72
   Hotamisligil GS, 2008, INT J OBESITY, V32, pS52, DOI 10.1038/ijo.2008.238
   Ikeya T, 2002, CURR BIOL, V12, P1293, DOI 10.1016/S0960-9822(02)01043-6
   Inoue YH., 2018, DROSOPHILA MODELS IN
   Jamar G, 2021, CRIT REV FOOD SCI, V61, P836, DOI 10.1080/10408398.2020.1747046
   Jiang HQ, 2009, CELL, V137, P1343, DOI 10.1016/j.cell.2009.05.014
   Jimenez-Gomez Y, 2013, CELL METAB, V18, P533, DOI 10.1016/j.cmet.2013.09.004
   Junger Martin A, 2003, J Biol, V2, P20, DOI 10.1186/1475-4924-2-20
   Kabel AM, 2021, FUND CLIN PHARMACOL, V35, P968, DOI 10.1111/fcp.12661
   Kim DH, 2013, J DIABETES, V5, P233, DOI 10.1111/1753-0407.12027
   Kim J, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms7846
   Kim SK, 2004, NATURE, V431, P316, DOI 10.1038/nature02897
   Kitade H, 2012, DIABETES, V61, P1680, DOI 10.2337/db11-1506
   Lemaitre B, 2007, ANNU REV IMMUNOL, V25, P697, DOI 10.1146/annurev.immunol.25.022106.141615
   Liggett MR, 2015, AGING-US, V7, P383, DOI 10.18632/aging.100759
   Lourido F, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-82944-4
   Ma T, 2022, NATURE, V603, P159, DOI 10.1038/s41586-022-04431-8
   Maillet F, 2008, CELL HOST MICROBE, V3, P293, DOI 10.1016/j.chom.2008.04.002
   Micchelli CA, 2006, NATURE, V439, P475, DOI 10.1038/nature04371
   Michel T, 2001, NATURE, V414, P756, DOI 10.1038/414756a
   Mishra AK, 2019, LEUKEMIA, V33, P2695, DOI 10.1038/s41375-019-0470-4
   Mo D, 2019, DRUG DES DEV THER, V13, P2769, DOI 10.2147/DDDT.S208327
   Moshapa FT, 2019, CARDIOL RES PRACT, V2019, DOI 10.1155/2019/9846312
   Mukherji A, 2013, CELL, V153, P812, DOI 10.1016/j.cell.2013.04.020
   Musial B, 2014, PLACENTA, V35, pA70, DOI 10.1016/j.placenta.2014.06.226
   Musselman LP, 2011, DIS MODEL MECH, V4, P842, DOI 10.1242/dmm.007948
   Musso G, 2011, ANNU REV MED, V62, P361, DOI 10.1146/annurev-med-012510-175505
   Ohlstein B, 2006, NATURE, V439, P470, DOI 10.1038/nature04333
   Oldefest M, 2013, BIOCHEM BIOPH RES CO, V436, P66, DOI 10.1016/j.bbrc.2013.04.107
   Persson C, 2007, INSECT BIOCHEM MOLEC, V37, P1309, DOI 10.1016/j.ibmb.2007.08.003
   Plosker GL, 2012, DRUGS, V72, P2289, DOI 10.2165/11209910-000000000-00000
   Post S, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00245
   Puig O, 2005, GENE DEV, V19, P2435, DOI 10.1101/gad.1340505
   Rambur A, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-16123-w
   Roglic G., 2016, INT J NONCOMMUN DIS, V1, P3, DOI [10.4103/2468-8827.184853, DOI 10.4103/2468-8827.184853]
   Roh SW, 2008, APPL ENVIRON MICROB, V74, P6171, DOI 10.1128/AEM.00301-08
   Ryu JH, 2008, SCIENCE, V319, P777, DOI 10.1126/science.1149357
   Schellenberg ES, 2013, ANN INTERN MED, V159, P543, DOI 10.7326/0003-4819-159-8-201310150-00007
   Shin SC, 2011, SCIENCE, V334, P670, DOI 10.1126/science.1212782
   Shoelson SE, 2007, GASTROENTEROLOGY, V132, P2169, DOI 10.1053/j.gastro.2007.03.059
   Storelli G, 2011, CELL METAB, V14, P403, DOI 10.1016/j.cmet.2011.07.012
   SUPEK F, 1994, J BIOL CHEM, V269, P24102
   von Frieling J, 2020, PLOS GENET, V16, DOI 10.1371/journal.pgen.1008789
   Wang HF, 2019, FOOD FUNCT, V10, P4102, DOI [10.1039/C9FO00109C, 10.1039/c9fo00109c]
   Weina T, 2022, HELIYON, V8, DOI 10.1016/j.heliyon.2022.e09957
   Westfall S, 2019, MOL BIOTECHNOL, V61, P1, DOI 10.1007/s12033-018-0119-y
   Winzell MS, 2004, DIABETES, V53, pS215, DOI 10.2337/diabetes.53.suppl_3.S215
   Yamanaka Y, 1997, J BIOL CHEM, V272, P30729, DOI 10.1074/jbc.272.49.30729
   Yu SC, 2018, EXP CELL RES, V368, P215, DOI 10.1016/j.yexcr.2018.04.032
   Zaidman-Remy A, 2006, IMMUNITY, V24, P463, DOI 10.1016/j.immuni.2006.02.012
   Zhang CS, 2017, NATURE, V548, P112, DOI 10.1038/nature23275
   Zhang XY, 2017, BIOCHEM BIOPH RES CO, V487, P910, DOI 10.1016/j.bbrc.2017.04.156
   Zhou J, 2020, P NATL ACAD SCI USA, V117, P9401, DOI 10.1073/pnas.1913976117
   Zhu ZX, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0144495
NR 87
TC 1
Z9 1
U1 6
U2 9
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1061-186X
EI 1029-2330
J9 J DRUG TARGET
JI J. Drug Target.
PD MAR 16
PY 2023
VL 31
IS 3
BP 261
EP 268
DI 10.1080/1061186X.2022.2144869
EA NOV 2022
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 8Z5RE
UT WOS:000882142400001
PM 36343203
DA 2023-06-08
ER

PT J
AU Davis, PJ
   Liu, ML
   Alemi, F
   Jensen, A
   Avramovic, S
   Levy, E
   Hayes, RB
   Schwartz, MD
AF Davis, P. Jordan
   Liu, Mengling
   Alemi, Farrokh
   Jensen, Ashley
   Avramovic, Sanja
   Levy, Esther
   Hayes, Richard B.
   Schwartz, Mark D.
TI Prior antibiotic exposure and risk of type 2 diabetes among Veterans
SO PRIMARY CARE DIABETES
LA English
DT Article
DE Type 2 diabetes; Antibiotics; Epidemiology; Veterans
ID GUT MICROBIOTA; OBESITY; MODULATION; ASSOCIATION; VANCOMYCIN
AB Background: Exposure to antibiotics may increase the risk of type 2 diabetes. Veterans are at increased risk for diabetes and for exposure to antibiotics.
   Objective: To determine the impact of antibiotic exposure for risk of diabetes.
   Design: Retrospective cohort study.
   Participants: Veterans at the New York Harbor Healthcare System enrolled in primary care, 2004-2014, with >= 2 glycosylated hemoglobin test results <6.5%.
   Main measures: The primary exposure was any antimicrobial prescribed >6 months prior to the date of diabetes diagnosis, loss to follow-up, death, or the end of the study, measured as the number of courses of antimicrobial prescriptions filled and the mean daily dose (MDD). The primary outcome was incident diagnosis of diabetes through 2014, defined >= 2 ICD-9 codes for diabetes or >= 2 prescriptions of diabetes medications, other than metformin. Cox proportional hazards regression was used to model antimicrobial medications, demographic and anthropometric measures, and comorbid cardiovascular conditions to incident diabetes. Models incorporated time varying covariates of antimicrobial medication and MDD to analyze associations by antimicrobial class.
   Key results: Among 14,361 Veterans, 9922 (69.1%) were prescribed any antimicrobial medication during the study period. 1413 (9.8%) individuals developed type 2 diabetes. Increased risk of diabetes was associated with >1 prescription (HR 1.13 [1.01-1.26]) compared to none. Time varying analysis of the total number of cumulative courses prescribed showed increased diabetes risk for cephalosporin (HR 1.17 [1.04-1.31]), macrolide (HR 1.08 [1.03-1.13]) and penicillin (HR 1.05 [1.02-1.07]). MDD showed increased risk per 100-unit (mg) increase in antibiotic exposure from (HR 1.05 [1.02-1.08]) for sulfonamide to (HR 1.70 [1.51-1.92]) for cephalosporin.
   Conclusion: Any and repeated exposure to certain antibiotics may increase diabetes risk among Veterans. Results from this study add to the growing evidence suggesting that antibiotic exposure increases risk for diabetes. Antibiotic stewardship may be enhanced by better understanding this risk, and may lower the incidence of diabetes in populations at risk. Published by Elsevier Ltd on behalf of Primary Care Diabetes Europe.
C1 [Davis, P. Jordan; Liu, Mengling; Levy, Esther; Hayes, Richard B.; Schwartz, Mark D.] NYU, Dept Populat Hlth, Sch Med, 227 East 30th St,704, New York, NY 10016 USA.
   [Jensen, Ashley; Schwartz, Mark D.] VA New York Harbor Healthcare Syst, New York, NY USA.
   [Alemi, Farrokh; Avramovic, Sanja] George Mason Univ, Fairfax, VA 22030 USA.
   [Jensen, Ashley] Univ Calgary, Fac Med, Calgary, AB, Canada.
C3 New York University; George Mason University; University of Calgary
RP Schwartz, MD (通讯作者)，NYU, Dept Populat Hlth, Sch Med, 227 East 30th St,704, New York, NY 10016 USA.
EM Mark.Schwartz@nyumc.org
RI Jensen, Ashley E/B-6452-2015; Avramovic, Sanja/AAK-8915-2020
OI Jensen, Ashley E/0000-0002-5702-2978; Avramovic,
   Sanja/0000-0002-6155-9241; Liu, Mengling/0000-0001-9758-8522; Hayes,
   Richard/0000-0002-0918-661X; Schwartz, Mark/0000-0002-7123-0060
CR Amar J, 2011, DIABETOLOGIA, V54, P3055, DOI 10.1007/s00125-011-2329-8
   Amer Diabet Assoc, 2014, DIABETES CARE, V37, pS81, DOI [10.2337/dc13-S067, 10.2337/dc14-S081, 10.2337/dc13-S011, 10.2337/dc10-S062, 10.2337/dc10-S011, 10.2337/dc11-S062, 10.2337/dc12-s064, 10.2337/dc11-S011]
   Backhed F, 2004, P NATL ACAD SCI USA, V101, P15718, DOI 10.1073/pnas.0407076101
   Blaser M, 2011, NATURE, V476, P393, DOI 10.1038/476393a
   Boursi B, 2015, EUR J ENDOCRINOL, V172, P639, DOI 10.1530/EJE-14-1163
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   Carvalho BM, 2012, DIABETOLOGIA, V55, P2823, DOI 10.1007/s00125-012-2648-4
   Centers for Disease Control and Prevention, 2017, NAT DIAB STAT REP, P2017
   Cho I, 2012, NATURE, V488, P621, DOI 10.1038/nature11400
   Chou HW, 2013, CLIN INFECT DIS, V57, P971, DOI 10.1093/cid/cit439
   Cox LM, 2014, CELL, V158, P705, DOI 10.1016/j.cell.2014.05.052
   De La Cochetiere MF, 2005, J CLIN MICROBIOL, V43, P5588, DOI 10.1128/JCM.43.11.5588-5592.2005
   Del Fiol FD, 2014, CHEMOTHERAPY, V60, P162, DOI 10.1159/000371737
   Department of Veterans Affairs. Health Services Research & Development, IMPR HLTH CAR VET DI
   Department of Veterans Affairs. VA Information Resource Center (VIReC). VA Corporate Data Warehouse (CDW), VA CORP DAT WAR CDW
   Dethlefsen L, 2011, P NATL ACAD SCI USA, V108, P4554, DOI 10.1073/pnas.1000087107
   Fonseca VA, 2009, DIABETES CARE, V32, P1, DOI [10.2337/dc09-S301, 10.2337/dc09-9033]
   Franck AJ, 2010, J AM PHARM ASSOC, V50, P726, DOI 10.1331/JAPhA.2010.09103
   Grundy SM, 2012, J AM COLL CARDIOL, V59, P635, DOI 10.1016/j.jacc.2011.08.080
   Hartstra AV, 2015, DIABETES CARE, V38, P159, DOI 10.2337/dc14-0769
   Hicks L.A., 2013, NEW ENGL J MED, V368, P1461
   Hwang I, 2015, FASEB J, V29, P2397, DOI 10.1096/fj.14-265983
   Jakobsson HE, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009836
   Jernberg C, 2007, ISME J, V1, P56, DOI 10.1038/ismej.2007.3
   Johnson AMF, 2013, CELL, V152, P673, DOI 10.1016/j.cell.2013.01.041
   Karlsson FH, 2012, NAT COMMUN, V3, DOI 10.1038/ncomms2266
   Kochanek Kenneth D, 2014, NCHS Data Brief, P1
   Lang A. J., 2016, General Technical Report - Southern Research Station, USDA Forest Service, P8
   Management of Diabetes Mellitus Update Working Group, 2010, VA DOD CLIN PRACT GU
   Membrez M, 2008, FASEB J, V22, P2416, DOI 10.1096/fj.07-102723
   Mikkelsen KH, 2015, J CLIN ENDOCR METAB, V100, P3633, DOI 10.1210/jc.2015-2696
   Miller DR, 2004, DIABETES CARE, V27, pB10, DOI 10.2337/diacare.27.suppl_2.B10
   Paprott R, 2015, DIABETES CARE, V38, P249, DOI 10.2337/dc14-1787
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Shapiro DJ, 2007, J ANTIMIC CHEMO ADV, V69, P234
   Sjolund M, 2003, ANN INTERN MED, V139, P483, DOI 10.7326/0003-4819-139-6-200309160-00011
   Tabak AG, 2012, LANCET, V379, P2279, DOI 10.1016/S0140-6736(12)60283-9
   Themeau T. M., 2000, STAT BIOL HLTH
   Tilg H, 2011, J CLIN INVEST, V121, P2126, DOI 10.1172/JCI58109
   Tremaroli V, 2012, NATURE, V489, P242, DOI 10.1038/nature11552
   Turnbaugh PJ, 2007, NATURE, V449, P804, DOI 10.1038/nature06244
   Turnbaugh PJ, 2009, J PHYSIOL-LONDON, V587, P4153, DOI 10.1113/jphysiol.2009.174136
   United States Department of Veterans Affairs. Health Services Research & Development. VA Informatics and Computing Infrastructure (VINCI), VA INF COMP INFR VIN
   Veterans Health Administration, 2010, PRIM CAR ALM
   VHA. Pharmacy Benefits Management Services, 2016, PHARM BEN MAN SERV
   Vrieze A, 2014, J HEPATOL, V60, P824, DOI 10.1016/j.jhep.2013.11.034
   Wichmann A, 2013, CELL HOST MICROBE, V14, P582, DOI 10.1016/j.chom.2013.09.012
NR 47
TC 10
Z9 10
U1 1
U2 3
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1751-9918
EI 1878-0210
J9 PRIM CARE DIABETES
JI Prim. Care Diabetes
PD FEB
PY 2019
VL 13
IS 1
BP 49
EP 56
DI 10.1016/j.pcd.2018.07.001
PG 8
WC Endocrinology & Metabolism; Primary Health Care
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; General & Internal Medicine
GA HI1RC
UT WOS:000456221700006
PM 30025678
DA 2023-06-08
ER

PT J
AU Kobyliak, N
   Falalyeyeva, T
   Kyriachenko, Y
   Tseyslyer, Y
   Kovalchuk, O
   Hadiliia, O
   Eslami, M
   Yousefi, B
   Abenavoli, L
   Fagoonee, S
   Pellicano, R
AF Kobyliak, Nazarii
   Falalyeyeva, Tetyana
   Kyriachenko, Yevheniia
   Tseyslyer, Yuliya
   Kovalchuk, Oleksandr
   Hadiliia, Olena
   Eslami, Majid
   Yousefi, Bahman
   Abenavoli, Ludovico
   Fagoonee, Sharmila
   Pellicano, Rinaldo
TI Akkermansia muciniphila as a novel powerful bacterial player in the
   treatment of metabolic disorders
SO MINERVA ENDOCRINOLOGY
LA English
DT Review
DE Akkermansia muciniphila; Obesity; Type 2 diabetes mellitus;
   Non-alcoholic fatty liver disease; Probiotics; Metabolic syndrome
ID GUT MICROBIOTA; FAECALIBACTERIUM-PRAUSNITZII; NEXT-GENERATION; OBESITY;
   DIET; PROBIOTICS; ABUNDANCE; METFORMIN; DISEASES; INFLAMMATION
AB Akkermansia muciniphila (A. muciniphila) is a mucin-degrading bacterium that commonly lives in the intestinal mucus layer. It is normally detected in human faecal specimens and is one of the few bacteria potentially associated to obesity development. In this narrative review, possible mechanisms that support how A. muciniphila is implicated in the patho-genesis of obesity and metabolic-associated disease are described with the evaluation of its role as an intermediary or independent agent whose manipulation could be useful in the management of metabolic disorders. The ampleness of A. muciniphila is notably diminished in obesity, type 2 diabetes (T2D), non-alcoholic fatty liver disease (NAFLD), car-diometabolic diseases and low-grade inflammation. Furthermore, an inverse relationship between A. muciniphila, body weight and insulin sensitivity has been observed in both humans and animals. Antidiabetic drugs, gastric bypass surgery, prebiotics and biologically active compounds, such as polyphenols or saponins, have been shown to be associated with A. muciniphila relative abundance and thus could have favourable effects on metabolic disorders. Furthermore, A. mu-ciniphila supplementation alone has been correlated with weight reduction and improvement of metabolic disorders, including fat mass gain, adipose tissue inflammation, metabolic endotoxaemia, and insulin resistance. Nevertheless, since the primary beneficial impacts of this bacterium have been predominantly investigated in various preclinical models, these results need to be confirmed in randomized clinical trials.
C1 [Kobyliak, Nazarii] Bogomolets Natl Med Univ, Dept Endocrinol, Kiev, Ukraine.
   [Kobyliak, Nazarii; Falalyeyeva, Tetyana] CSD Hlth Care, Med Lab, Kiev, Ukraine.
   [Falalyeyeva, Tetyana; Kyriachenko, Yevheniia; Tseyslyer, Yuliya; Kovalchuk, Oleksandr; Hadiliia, Olena] Taras Shevchenko Natl Univ, Kiev, Ukraine.
   [Kovalchuk, Oleksandr] Bogomolets Natl Med Univ, Dept Human Anat, Kiev, Ukraine.
   [Eslami, Majid] Semnan Univ Med Sci, Canc Res Ctr, Semnan, Iran.
   [Yousefi, Bahman] Semnan Univ Med Sci, Dept Immunol, Semnan, Iran.
   [Abenavoli, Ludovico] Magna Graecia Univ Catanzaro, Dept Hlth Sci, Catanzaro, Italy.
   [Fagoonee, Sharmila] CNR, Mol Biotechnol Ctr, Inst Biostruct & Bioimaging, Turin, Italy.
   [Pellicano, Rinaldo] Molinette S Giovanni Antica Sede Hosp, Unit Gastroenterol, Turin, Italy.
C3 Bogomolets National Medical University; Ministry of Education & Science
   of Ukraine; Taras Shevchenko National University Kiev; Bogomolets
   National Medical University; Semnan University of Medical Sciences;
   Semnan University of Medical Sciences; Magna Graecia University of
   Catanzaro; Consiglio Nazionale delle Ricerche (CNR); Istituto di
   Biostrutture e Bioimmagini (IBB-CNR)
RP Kobyliak, N (通讯作者)，Bogomolets Natl Med Univ, Dept Endocrinol, Kiev, Ukraine.
EM nazariikobyliak@gmail.com
RI Kobyliak, Nazarii/R-8703-2016; Kovalchuk, Oleksandr/B-6524-2018;
   Kovalchuk, Oleksandr/GQP-1391-2022
OI Kobyliak, Nazarii/0000-0001-9814-689X; Kovalchuk,
   Oleksandr/0000-0002-6311-3518; Falalyeyeva, Tetyana/0000-0002-4415-9676
CR Abenavoli L, 2020, MINERVA ENDOCRINOL, V45, P277, DOI 10.23736/S0391-1977.20.03376-3
   Abenavoli L, 2020, DISEASES-BASEL, V8, DOI 10.3390/diseases8020020
   Al-Goblan AS, 2014, DIABETES METAB SYNDR, V7, P587, DOI 10.2147/DMSO.S67400
   Aludwan M, 2020, CLIN DIABETOL, V9, P313, DOI 10.5603/DK.2020.0036
   Aludwan M, 2020, MINERVA ENDOCRINOL, V45, P172, DOI 10.23736/S0391-1977.20.03161-2
   American Diabetes Association, 2015, DIABETES CARE S, V38, pS8
   Ashrafian F, 2019, FRONT MICROBIOL, V10, DOI 10.3389/fmicb.2019.02155
   Bahman Y, 2021, MINERVA BIOTECHNOL B, V33, P76, DOI 10.23736/S2724-542X.21.02759-2
   Barrea L, 2021, MINERVA ENDOCRINOL, V46, P177, DOI 10.23736/S2724-6507.20.03299-X
   Brodmann T, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.01725
   Brunkwall L, 2017, DIABETOLOGIA, V60, P943, DOI 10.1007/s00125-017-4278-3
   Cani PD, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.01765
   Cani PD, 2015, CURR OPIN BIOTECH, V32, P21, DOI 10.1016/j.copbio.2014.10.006
   Carding Simon, 2015, Microbial Ecology in Health and Disease, V26, P26191, DOI 10.3402/mehd.v26.26191
   Chang CJ, 2018, INT J OBESITY, V42, P231, DOI 10.1038/ijo.2017.149
   Clemente JC, 2012, CELL, V148, P1258, DOI 10.1016/j.cell.2012.01.035
   Coil David A, 2020, J Genomics, V8, P25, DOI 10.7150/jgen.43162
   Cortez RV, 2018, SURG OBES RELAT DIS, V14, P1748, DOI 10.1016/j.soard.2018.07.021
   Dao MC, 2019, AM J PHYSIOL-ENDOC M, V317, pE446, DOI 10.1152/ajpendo.00140.2019
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   De Oca APM, 2021, MINERVA ENDOCRINOL, V46, P168, DOI 10.23736/S2724-6507.20.03369-6
   Depommier C, 2019, NAT MED, V25, P1096, DOI 10.1038/s41591-019-0495-2
   Devecchi A, 2020, MINERVA GASTROENTERO, V66, P293, DOI 10.23736/S1121-421X.20.02748-8
   Dipasquale V, 2020, MINERVA MED, V111, P141, DOI 10.23736/S0026-4806.19.06320-1
   Doulberis M, 2020, MINERVA ENDOCRINOL, V45, P243, DOI 10.23736/S0391-1977.19.03058-X
   Doyle LM, 2019, CELLS-BASEL, V8, DOI 10.3390/cells8070727
   Du FY, 2018, J PHARMACOL EXP THER, V365, P676, DOI 10.1124/jpet.118.248575
   Eslami M, 2021, DIABETIC MED, V38, DOI 10.1111/dme.14415
   Eslami M, 2020, J GASTROINTEST CANC, V51, P738, DOI 10.1007/s12029-019-00329-3
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Everard A, 2011, DIABETES, V60, P2775, DOI 10.2337/db11-0227
   Falalyeyeva T, 2021, MINERVA BIOTECHNOL B, V33, P51, DOI 10.23736/S2724-542X.21.02803-0
   Geerlings SY, 2018, MICROORGANISMS, V6, DOI 10.3390/microorganisms6030075
   Giannoudaki E, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-11944-w
   Hansen KB, 2011, J CLIN ENDOCR METAB, V96, pE1409, DOI 10.1210/jc.2011-0647
   Huang K, 2015, CARBOHYD RES, V415, P60, DOI 10.1016/j.carres.2015.08.001
   Jiang JY, 2013, PREV MED, V57, P60, DOI 10.1016/j.ypmed.2013.04.014
   Jung DH, 2014, DIABETES RES CLIN PR, V103, P51, DOI 10.1016/j.diabres.2013.09.018
   Karimi K, 2016, REV ENDOCR METAB DIS, V17, P389, DOI 10.1007/s11154-016-9393-9
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Khan TJ, 2018, OMICS, V22, P154, DOI 10.1089/omi.2017.0130
   Kim S, 2020, APPL ENVIRON MICROB, V86, DOI 10.1128/AEM.03004-19
   Kobyliak N., 2020, Obesity Medicine, V19, P100248, DOI 10.1016/j.obmed.2020.100248
   Kobyliak N, 2018, DIABETES RES CLIN PR, V141, P190, DOI 10.1016/j.diabres.2018.05.005
   Kobyliak N, 2020, J DIABETES METAB DIS, V19, P289, DOI 10.1007/s40200-020-00506-3
   Kobyliak N, 2019, CLIN DIABETOL, V8, P205, DOI 10.5603/DK.2019.0016
   Kobyliak Nazarii, 2016, Clujul Med, V89, P229, DOI 10.15386/cjmed-632
   Kong S, 2021, MINERVA MED, V112, P418, DOI 10.23736/S0026-4806.19.06356-0
   Kyriachenko Y, 2019, WORLD J DIABETES, V10, P154, DOI 10.4239/wjd.v10.i3.154
   Lawenius L, 2020, AM J PHYSIOL-ENDOC M, V318, pE480, DOI 10.1152/ajpendo.00425.2019
   Lazar V, 2019, FRONT NUTR, V6, DOI 10.3389/fnut.2019.00021
   Lee DM, 2018, CARDIOVASC DIABETOL, V17, DOI 10.1186/s12933-018-0708-x
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Liguori A, 2021, MINERVA GASTROENTERO, V67, P164, DOI 10.23736/S2724-5985.21.02801-4
   Lukovac S, 2014, MBIO, V5, DOI 10.1128/mBio.01438-14
   Luzi L, 2021, MINERVA ENDOCRINOL, V46, P193, DOI 10.23736/S2724-6507.20.03402-1
   Macchione IG, 2019, EUR REV MED PHARMACO, V23, P8075, DOI 10.26355/eurrev_201909_19024
   Leal-Diaz AM, 2016, SCI REP-UK, V6, DOI 10.1038/srep34242
   Mehrpouya-Bahrami P, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-15154-6
   Meleshko T, 2021, MINERVA BIOTECHNOL B, V33, P109, DOI 10.23736/S2724-542X.21.02784-X
   Montandon SA, 2017, GENES-BASEL, V8, DOI 10.3390/genes8100250
   Murphy EF, 2010, GUT, V59, P1635, DOI 10.1136/gut.2010.215665
   Napolitano A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100778
   Ohira H, 2017, J ATHEROSCLER THROMB, V24, P660, DOI 10.5551/jat.RV17006
   Ottman N, 2017, BEST PRACT RES CL GA, V31, P637, DOI 10.1016/j.bpg.2017.10.001
   Ottman N, 2016, FRONT MICROBIOL, V7, DOI 10.3389/fmicb.2016.01157
   Perna S, 2020, MINERVA GASTROENTERO, V66, P211, DOI 10.23736/S1121-421X.20.02669-0
   Perraudeau F, 2020, BMJ OPEN DIAB RES CA, V8, DOI 10.1136/bmjdrc-2020-001319
   Phillips CM, 2013, REV ENDOCR METAB DIS, V14, P219, DOI 10.1007/s11154-013-9252-x
   Plovier H, 2017, NAT MED, V23, P107, DOI 10.1038/nm.4236
   Remely M, 2015, WIEN KLIN WOCHENSCHR, V127, P394, DOI 10.1007/s00508-015-0755-1
   Reunanen J, 2015, APPL ENVIRON MICROB, V81, P3655, DOI 10.1128/AEM.04050-14
   Roshanravan N, 2017, J CARDIOVASC THORAC, V9, P183, DOI 10.15171/jcvtr.2017.32
   Schneeberger M, 2015, SCI REP-UK, V5, DOI 10.1038/srep16643
   Seck EH, 2019, INT J OBESITY, V43, P862, DOI 10.1038/s41366-018-0201-3
   Shen W, 2017, FRONT MICROBIOL, V8, P1, DOI 10.3389/fmicb.2017.00272
   Sheng LL, 2018, FASEB J, V32, P6371, DOI 10.1096/fj.201800370R
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Singh H, 2019, GEROSCIENCE, V41, P907, DOI 10.1007/s11357-019-00098-8
   Sonnenburg JL, 2016, NATURE, V535, P56, DOI 10.1038/nature18846
   Stalla FM, 2020, MINERVA GASTROENT D
   van der Ark KCH, 2017, FOOD RES INT, V102, P372, DOI 10.1016/j.foodres.2017.09.004
   Vu NB, 2021, MINERVA MED, V112, P384, DOI 10.23736/S0026-4806.20.07205-5
   Walker Jeanne M, 2019, J Clin Transl Res, V4, P122
   Wang Zhang, 2018, Endocrinol Diabetes Metab, V1, pe00009, DOI 10.1002/edm2.9
   WHO, 2020, OBESITY
   Wu FF, 2020, ANAEROBE, V61, DOI 10.1016/j.anaerobe.2019.102138
   Wu TR, 2019, GUT, V68, P248, DOI 10.1136/gutjnl-2017-315458
   Xu Y, 2020, FRONT MICROBIOL, V11, DOI 10.3389/fmicb.2020.00219
   Yang YJ, 2019, NEUROPSYCHOPHARMACOL, V44, P2054, DOI 10.1038/s41386-019-0437-1
   Yassour M, 2016, GENOME MED, V8, DOI 10.1186/s13073-016-0271-6
   Zhang T, 2019, MICROB BIOTECHNOL, V12, P1109, DOI 10.1111/1751-7915.13410
   Zhu LD, 2020, VET RES, V51, DOI 10.1186/s13567-020-00755-3
NR 93
TC 6
Z9 6
U1 5
U2 22
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 2724-6507
EI 2724-6116
J9 MINERVA ENDOCRINOL
JI Minerva Endocrinol.
PD JUN
PY 2022
VL 47
IS 2
BP 242
EP 252
DI 10.23736/S2724-6507.22.03752-6
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 3D8JN
UT WOS:000829542500007
PM 35103461
DA 2023-06-08
ER

PT J
AU Zhang, WY
   Zhang, HH
   Yu, CH
   Fang, J
   Ying, HZ
AF Zhang, Wen-You
   Zhang, Huan-Huan
   Yu, Chen-Huan
   Fang, Jie
   Ying, Hua-Zhong
TI Ethanol extract of Atractylodis macrocephalae Rhizoma ameliorates
   insulin resistance and gut microbiota in type 2 diabetic db/db mice
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Type 2 diabetes mellitus; Inflammation; Glucagon-like peptide-1
   receptor; Forkhead box O1; Bacteroides thetaiotaomicron;
   Methanobrevibacter smithii
ID FORKHEAD TRANSCRIPTION FACTOR; PANCREATIC BETA-CELLS;
   BACTEROIDES-THETAIOTAOMICRON; METHANOBREVIBACTER-SMITHII; OXIDATIVE
   STRESS; HUMAN HEALTH; FATTY-ACIDS; IN-VITRO; OBESITY; METFORMIN
AB Atractylodis macrocephalae Rhizoma is widely used as a functional food in Asia. It can enhance glucose and lipid metabolism in the obesity patients with adiposity. In this study, therapeutic effects and the underlying molecular mechanisms of its ethanol extract (AMK) were investigated in db/db mice. Oral treatment with AMK at a dose of 100 mg/kg for three weeks significantly decreased the blood glucose, serum triacylglycerol, total cholesterol, HOMA-IR, endotoxin and IL-10. Besides, AMK increased the abundance of Bacteroides thetaiotaomicron and Methanobrevibacter smithii in gut microbiota and improved the histological abnormalities of liver, adipocytes, pancreas and small intestine in diabetic mice. Moreover, AMK upregulated the expressions of GLP-1R, PI3K and PDX-1, but downregulated FOXO1 and NF-kappa B p65 in liver and pancreas tissues of diabetic mice. These results suggested that AMK ameliorated glucose metabolism by regulating GLP-1R/PI3K/PDX-1 pathway and gut microbiota, and it could be developed as a medicinal herb for T2DM treatment.
C1 [Zhang, Wen-You; Zhang, Huan-Huan; Yu, Chen-Huan; Fang, Jie; Ying, Hua-Zhong] Zhejiang Acad Med Sci, Key Lab Expt Anim & Safety Evaluat, Hangzhou 310013, Zhejiang, Peoples R China.
C3 Zhejiang Academy of Medical Sciences
RP Ying, HZ (通讯作者)，Zhejiang Acad Med Sci, Key Lab Expt Anim & Safety Evaluat, Hangzhou 310013, Zhejiang, Peoples R China.
EM HZYing0101@163.com
FU Zhejiang Natural Science Foundation [LZ17H280001]; National Natural
   Science Foundation of China [81573591]; Zhejiang Science and Technology
   Foundation [2014F10033]; Zhejiang Innovation Discipline Project for
   "Laboratory Animal Genetic Engineering" [201604]; Zhejiang Training
   Project for High-level Innovative Health Talents [201206]
FX This work is supported by Zhejiang Natural Science Foundation (No.
   LZ17H280001), National Natural Science Foundation of China (No.
   81573591), Zhejiang Science and Technology Foundation (No. 2014F10033),
   Zhejiang Innovation Discipline Project for "Laboratory Animal Genetic
   Engineering" (No. 201604), and Zhejiang Training Project for High-level
   Innovative Health Talents (No. 201206).
CR Baothman OA, 2016, LIPIDS HEALTH DIS, V15, DOI 10.1186/s12944-016-0278-4
   Bastien-Dionne PO, 2011, DIABETES, V60, P3217, DOI 10.2337/db11-0101
   Brunet A, 1999, CELL, V96, P857, DOI 10.1016/S0092-8674(00)80595-4
   Burke SJ, 2015, AM J PHYSIOL-ENDOC M, V309, pE715, DOI 10.1152/ajpendo.00153.2015
   Clemente JC, 2012, CELL, V148, P1258, DOI 10.1016/j.cell.2012.01.035
   Cooke AA, 2016, EUR J PHARMACOL, V785, P207, DOI 10.1016/j.ejphar.2016.04.021
   Dai B, 2016, J ETHNOPHARMACOL, V192, P382, DOI 10.1016/j.jep.2016.07.024
   Drucker D. J., 2006, LANCET
   Ebbert JO, 2013, NUTRIENTS, V5, P498, DOI 10.3390/nu5020498
   Everard A, 2013, BEST PRACT RES CL GA, V27, P73, DOI 10.1016/j.bpg.2013.03.007
   Fernandes JD, 2016, DIABETES RES CLIN PR, V117, P48, DOI 10.1016/j.diabres.2016.04.016
   Fullerton MD, 2013, NAT MED, V19, P1649, DOI 10.1038/nm.3372
   Hawkins PT, 2015, BBA-MOL CELL BIOL L, V1851, P882, DOI 10.1016/j.bbalip.2014.12.006
   Herrema H., 2016, DIABETOLOGIA
   Hoist J., 2011, DIABETES OBESITY MET
   Hsieh PS, 2011, WORLD J GASTROENTERO, V17, P5240, DOI 10.3748/wjg.v17.i48.5240
   Johnson AMF, 2013, CELL, V152, P673, DOI 10.1016/j.cell.2013.01.041
   Kaneto H, 2008, ENDOCR J, V55, P235, DOI 10.1507/endocrj.K07E-041
   Kaneto H, 2015, INT J MOL SCI, V16, P6281, DOI 10.3390/ijms16036281
   Kelly D, 2004, NAT IMMUNOL, V5, P104, DOI 10.1038/ni1018
   Kim CK, 2011, J ETHNOPHARMACOL, V137, P396, DOI 10.1016/j.jep.2011.05.036
   Kitamura T, 2002, J CLIN INVEST, V110, P1839, DOI 10.1172/JCI200216857
   Kohn AD, 1996, J BIOL CHEM, V271, P31372, DOI 10.1074/jbc.271.49.31372
   Leech CA, 2011, PROG BIOPHYS MOL BIO, V107, P236, DOI 10.1016/j.pbiomolbio.2011.07.005
   Li CQ, 2007, J ETHNOPHARMACOL, V114, P212, DOI 10.1016/j.jep.2007.08.002
   Li DT, 2016, BIOTECHNOL ADV, V34, P1210, DOI 10.1016/j.biotechadv.2016.08.003
   Li WJ, 2017, SCI REP-UK, V7, DOI 10.1038/srep44659
   Li XC, 2012, MOLECULES, V17, P13457, DOI 10.3390/molecules171113457
   Madiraju AK, 2014, NATURE, V510, P542, DOI 10.1038/nature13270
   Martens EC, 2009, J BIOL CHEM, V284, P24673, DOI 10.1074/jbc.R109.022848
   Million M, 2012, INT J OBESITY, V36, P817, DOI 10.1038/ijo.2011.153
   Mimee M, 2015, CELL SYST, V1, P62, DOI 10.1016/j.cels.2015.06.001
   More Vijay R, 2012, Comp Hepatol, V11, P1, DOI 10.1186/1476-5926-11-1
   Owen MR, 2000, BIOCHEM J, V348, P607, DOI 10.1042/0264-6021:3480607
   Purves GI, 2009, J PHYSIOL-LONDON, V587, P3639, DOI 10.1113/jphysiol.2009.173534
   Samuel BS, 2007, P NATL ACAD SCI USA, V104, P10643, DOI 10.1073/pnas.0704189104
   Shi M, 2017, J FUNCT FOODS, V30, P16, DOI 10.1016/j.jff.2016.12.036
   Shoaie S, 2013, SCI REP-UK, V3, DOI 10.1038/srep02532
   Skarra DV, 2015, MOL CELL ENDOCRINOL, V405, P14, DOI 10.1016/j.mce.2015.02.006
   Song HP, 2015, J ETHNOPHARMACOL, V159, P23, DOI 10.1016/j.jep.2014.10.059
   Song HP, 2014, J ETHNOPHARMACOL, V152, P163, DOI 10.1016/j.jep.2013.12.049
   Tahrani A. A., 2016, NATURE REV ENDOCRINO, V12
   Tangvarasittichai S, 2015, WORLD J DIABETES, V6, P456, DOI 10.4239/wjd.v6.i3.456
   Tottey W, 2015, ANAEROBE, V34, P50, DOI 10.1016/j.anaerobe.2015.04.009
   Turnbaugh PJ, 2009, NATURE, V457, P480, DOI 10.1038/nature07540
   Ulevitch RJ, 1999, CURRENT OPINION IMMU
   Vaez H, 2016, INT IMMUNOPHARMACOL, V40, P501, DOI 10.1016/j.intimp.2016.10.002
   Vaez H, 2016, EUR J PHARMACOL, V772, P115, DOI 10.1016/j.ejphar.2015.12.030
   van Bueren AL, 2017, SCI REP-UK, V7, DOI 10.1038/srep40478
   Wang JH, 2015, SCI REP-UK, V5, DOI 10.1038/srep08391
   Wang KT, 2010, J PHARM PHARMACOL, V62, P381, DOI 10.1211/jpp.62.03.0014
   Wang R., 2014, MANUFACTURING VEGETA, P1, DOI DOI 10.1155/2014/926381
   Yan FJ, 2017, J FUNCT FOODS, V30, P270, DOI 10.1016/j.jff.2017.01.027
   Yang XH, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/2968462
   Ye Y, 2011, J ETHNOPHARMACOL, V136, P279, DOI 10.1016/j.jep.2011.04.020
   Zhang JL, 2015, EUR J PHARMACOL, V765, P94, DOI 10.1016/j.ejphar.2015.08.022
   Zhao H, 2016, J MOL CELL CARDIOL, V101, P11, DOI 10.1016/j.yjmcc.2016.10.017
NR 57
TC 16
Z9 20
U1 3
U2 62
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1756-4646
J9 J FUNCT FOODS
JI J. Funct. Food.
PD DEC
PY 2017
VL 39
BP 139
EP 151
DI 10.1016/j.jff.2017.10.020
PG 13
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA FQ2RW
UT WOS:000418206000018
DA 2023-06-08
ER


PT J
AU Wu, SB
   Yang, SJ
   Wang, MM
   Song, N
   Feng, J
   Wu, H
   Yang, AD
   Liu, CJ
   Li, YN
   Guo, F
   Qiao, JJ
AF Wu, Shengbo
   Yang, Shujuan
   Wang, Manman
   Song, Nan
   Feng, Jie
   Wu, Hao
   Yang, Aidong
   Liu, Chunjiang
   Li, Yanni
   Guo, Fei
   Qiao, Jianjun
TI Quorum sensing-based interactions among drugs, microbes, and diseases
SO SCIENCE CHINA-LIFE SCIENCES
LA English
DT Article
DE quorum sensing; drugs; microbe-disease association; microbe-host
   interaction; gut microbiota; personalized medicine
ID SURFACE-PLASMON RESONANCE; PSEUDOMONAS-AERUGINOSA; GUT MICROBIOTA;
   DATABASE; BINDING; IDENTIFICATION; METFORMIN; DOCKING; SIGNAL;
   INHIBITORS
AB Many diseases and health conditions are closely related to various microbes, which participate in complex interactions with diverse drugs; nonetheless, the detailed targets of such drugs remain to be elucidated. Many existing studies have reported causal associations among drugs, gut microbes, or diseases, calling for a workflow to reveal their intricate interactions. In this study, we developed a systematic workflow comprising three modules to construct a Quorum Sensing-based Drug-Microbe-Disease (QS-DMD) database (http://www.qsdmd.lbci.net/), which includes diverse interactions for more than 8,000 drugs, 163 microbes, and 42 common diseases. Potential interactions between microbes and more than 8,000 drugs have been systematically studied by targeting microbial QS receptors combined with a docking-based virtual screening technique and in vitro experimental validations. Furthermore, we have constructed a QS-based drug-receptor interaction network, proposed a systematic framework including various drug-receptor-microbe-disease connections, and mapped a paradigmatic circular interaction network based on the QS-DMD, which can provide the underlying QS-based mechanisms for the reported causal associations. The QS-DMD will promote an understanding of personalized medicine and the development of potential therapies for diverse diseases. This work contributes to a paradigm for the construction of a molecule-receptor-microbe-disease interaction network for human health that may form one of the key knowledge maps of precision medicine in the future.
C1 [Wu, Shengbo; Yang, Shujuan; Wang, Manman; Liu, Chunjiang; Li, Yanni; Qiao, Jianjun] Tianjin Univ, Sch Chem Engn & Technol, Tianjin 300072, Peoples R China.
   [Guo, Fei] Cent South Univ, Sch Comp Sci & Engn, Changsha 410083, Peoples R China.
   [Wu, Shengbo; Liu, Chunjiang] Tianjin Univ, State Key Lab Chem Engn, Tianjin 300072, Peoples R China.
   [Wu, Shengbo; Liu, Chunjiang; Li, Yanni; Qiao, Jianjun] Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300072, Peoples R China.
   [Li, Yanni; Qiao, Jianjun] Tianjin Univ, Key Lab Syst Bioengn, Minist Educ, Tianjin 300072, Peoples R China.
   [Song, Nan; Feng, Jie] Tianjin Univ, Coll Intelligence & Comp, Sch Comp Sci & Technol, Tianjin 300350, Peoples R China.
   [Yang, Aidong] Univ Oxford, Dept Engn Sci, Oxford OX1 3PJ, England.
   [Wu, Hao; Qiao, Jianjun] Tianjin Univ, Inst Shaoxing, Shaoxing 312300, Peoples R China.
C3 Tianjin University; Central South University; Tianjin University;
   Tianjin University; Tianjin University; University of Oxford; Tianjin
   University
RP Li, YN; Qiao, JJ (通讯作者)，Tianjin Univ, Sch Chem Engn & Technol, Tianjin 300072, Peoples R China.; Guo, F (通讯作者)，Cent South Univ, Sch Comp Sci & Engn, Changsha 410083, Peoples R China.; Li, YN; Qiao, JJ (通讯作者)，Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300072, Peoples R China.; Li, YN; Qiao, JJ (通讯作者)，Tianjin Univ, Key Lab Syst Bioengn, Minist Educ, Tianjin 300072, Peoples R China.; Qiao, JJ (通讯作者)，Tianjin Univ, Inst Shaoxing, Shaoxing 312300, Peoples R China.
EM liyanni@tju.edu.cn; guofei@csu.edu.cn; jianjunq@tju.edu.cn
RI Wu, Shengbo/GRK-0088-2022
OI Wu, Shengbo/0000-0001-7497-2935
FU National Key Research and Development Project of China [2019YFA0905600,
   2020YFA0907900]; National Natural Science Foundation of China [31570089,
   31770076, 62172296]; Funds for Creative Research Groups of China
   [21621004]; New Century Outstanding Talent Support Program, Education
   Ministry of China
FX This work was supported by the National Key Research and Development
   Project of China (2019YFA0905600, 2020YFA0907900), the National Natural
   Science Foundation of China (31570089, 31770076, 62172296), the Funds
   for Creative Research Groups of China (21621004), and the New Century
   Outstanding Talent Support Program, Education Ministry of China.
CR Abbas HA, 2017, AFR HEALTH SCI, V17, P808, DOI 10.4314/ahs.v17i3.24
   Aggeletopoulou I, 2019, MICROB PATHOGENESIS, V137, DOI 10.1016/j.micpath.2019.103774
   Apweiler R, 2004, NUCLEIC ACIDS RES, V32, pD115, DOI [10.1093/nar/gkh131, 10.1093/nar/gkw1099]
   Backhed F, 2015, CELL HOST MICROBE, V17, P690, DOI [10.1016/j.chom.2015.04.004, 10.1016/j.chom.2015.05.012]
   Barretto SA, 2021, MICROBIOME, V9, DOI 10.1186/s40168-021-01050-9
   Berman HM, 2000, NUCLEIC ACIDS RES, V28, P235, DOI 10.1093/nar/28.1.235
   Bockova M, 2019, ANNU REV ANAL CHEM, V12, P151, DOI 10.1146/annurev-anchem-061318-115106
   Bottomley MJ, 2007, J BIOL CHEM, V282, P13592, DOI 10.1074/jbc.M700556200
   Breuninger TA, 2021, MICROBIOME, V9, DOI 10.1186/s40168-020-00969-9
   Chassaing B, 2017, GUT, V66, P1414, DOI 10.1136/gutjnl-2016-313099
   Chen GZ, 2011, MOL CELL, V42, P199, DOI 10.1016/j.molcel.2011.04.003
   Chen X, 2002, NATURE, V415, P545, DOI 10.1038/415545a
   Cheng L, 2020, NUCLEIC ACIDS RES, V48, pD554, DOI 10.1093/nar/gkz843
   Collison M, 2012, BRIEF BIOINFORM, V13, P751, DOI 10.1093/bib/bbs002
   Copeland RA, 2016, NAT REV DRUG DISCOV, V15, P87, DOI 10.1038/nrd.2015.18
   de Almeida FA, 2018, MICROB PATHOGENESIS, V121, P369, DOI 10.1016/j.micpath.2018.05.014
   Defoirdt T, 2018, TRENDS MICROBIOL, V26, P313, DOI 10.1016/j.tim.2017.10.005
   Desai MS, 2016, CELL, V167, P1339, DOI 10.1016/j.cell.2016.10.043
   Devkota S, 2012, NATURE, V487, P104, DOI 10.1038/nature11225
   Dubey BN, 2016, SCI ADV, V2, DOI 10.1126/sciadv.1600823
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Frame LA, 2020, NUTR REV, V78, P798, DOI 10.1093/nutrit/nuz106
   Gaulton A, 2017, NUCLEIC ACIDS RES, V45, pD945, DOI 10.1093/nar/gkw1074
   Hassan R, 2021, BRIEF BIOINFORM, V22, DOI 10.1093/bib/bbaa292
   Honda K, 2016, NATURE, V535, P75, DOI 10.1038/nature18848
   Ilangovan A, 2013, PLOS PATHOG, V9, DOI 10.1371/journal.ppat.1003508
   Imhann F, 2016, GUT, V65, P740, DOI 10.1136/gutjnl-2015-310376
   Irwin JJ, 2005, J CHEM INF MODEL, V45, P177, DOI 10.1021/ci049714+
   Jackson MA, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-018-05184-7
   Jackson MA, 2016, GUT, V65, P749, DOI 10.1136/gutjnl-2015-310861
   Javdan B, 2020, CELL, V181, P1661, DOI 10.1016/j.cell.2020.05.001
   Kim S, 2016, NUCLEIC ACIDS RES, V44, pD1202, DOI 10.1093/nar/gkv951
   Kim Y, 2017, PROTEINS, V85, P1831, DOI 10.1002/prot.25336
   Klunemann M, 2021, NATURE, V597, P533, DOI 10.1038/s41586-021-03891-8
   Li HL, 2006, NUCLEIC ACIDS RES, V34, pW219, DOI 10.1093/nar/gkl114
   Li LY, 2020, MICROBIOME, V8, DOI 10.1186/s40168-020-00806-z
   Lintz MJ, 2011, P NATL ACAD SCI USA, V108, P15763, DOI 10.1073/pnas.1112398108
   Liu TQ, 2007, NUCLEIC ACIDS RES, V35, pD198, DOI 10.1093/nar/gkl999
   Luo J, 2020, INT J BIOL MACROMOL, V163, P200, DOI 10.1016/j.ijbiomac.2020.06.263
   Maier L, 2018, NATURE, V555, P623, DOI 10.1038/nature25979
   Maier L, 2017, CURR OPIN MICROBIOL, V39, P128, DOI 10.1016/j.mib.2017.11.001
   Miller ST, 2004, MOL CELL, V15, P677, DOI 10.1016/j.molcel.2004.07.020
   Nguyen Y, 2015, MBIO, V6, DOI 10.1128/mBio.02429-14
   Panebianco C, 2018, MICROBIOME, V6, DOI 10.1186/s40168-018-0483-7
   Patching SG, 2014, BBA-BIOMEMBRANES, V1838, P43, DOI 10.1016/j.bbamem.2013.04.028
   Qi HJ, 2018, SCI CHINA LIFE SCI, V61, P476, DOI 10.1007/s11427-017-9270-x
   Rajamanikandan S, 2017, J BIOMOL STRUCT DYN, V35, P897, DOI 10.1080/07391102.2016.1166455
   Rajput A, 2018, NUCLEIC ACIDS RES, V46, pD894, DOI 10.1093/nar/gkx1157
   Rajput A, 2016, NUCLEIC ACIDS RES, V44, pD634, DOI 10.1093/nar/gkv1076
   Raju SC, 2020, MICROBIOME, V8, DOI 10.1186/s40168-020-00893-y
   Rathinam P, 2017, BIOFOULING, V33, P624, DOI 10.1080/08927014.2017.1350655
   Savage N, 2020, NATURE, V577, pS10, DOI 10.1038/d41586-020-00196-0
   Scarano S, 2010, BIOSENS BIOELECTRON, V25, P957, DOI 10.1016/j.bios.2009.08.039
   Sherry ST, 2001, NUCLEIC ACIDS RES, V29, P308, DOI 10.1093/nar/29.1.308
   Singh S, 2018, BIOIMPACTS, V8, P201, DOI 10.15171/bi.2018.23
   Sonnenburg ED, 2016, NATURE, V529, P212, DOI 10.1038/nature16504
   Suez Jotham, 2014, Nature, V514, P181, DOI 10.1038/nature13793
   Szunerits S, 2013, ANAL BIOANAL CHEM, V405, P1435, DOI 10.1007/s00216-012-6624-0
   Tap J, 2021, MICROBIOME, V9, DOI 10.1186/s40168-021-01018-9
   Truhlar DG, 2007, J COMPUT CHEM, V28, P73, DOI 10.1002/jcc.20529
   Vila AV, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-019-14177-z
   Wan Y, 2019, GUT, V68, P1417, DOI 10.1136/gutjnl-2018-317609
   Weersma RK, 2020, GUT, V69, P1510, DOI 10.1136/gutjnl-2019-320204
   Wishart DS, 2018, NUCLEIC ACIDS RES, V46, pD608, DOI 10.1093/nar/gkx1089
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Wu SB, 2022, CHEM ENG J, V445, DOI 10.1016/j.cej.2022.136720
   Wu SB, 2021, TRENDS MICROBIOL, V29, P1130, DOI 10.1016/j.tim.2021.04.006
   Wu SB, 2021, METAB ENG, V67, P186, DOI 10.1016/j.ymben.2021.07.002
   Wu SB, 2021, BRIEF BIOINFORM, V22, DOI 10.1093/bib/bbaa218
   Wu SB, 2020, CELL MOL LIFE SCI, V77, P1319, DOI 10.1007/s00018-019-03326-8
   Wynendaele E, 2013, NUCLEIC ACIDS RES, V41, pD655, DOI 10.1093/nar/gks1137
   Xiong T, 2020, SENSOR ACTUAT B-CHEM, V304, DOI [10.1126/scitranslmed.3009124, 10.1016/j.snb.2019.127310]
   Xiong ZP, 2022, SCI CHINA LIFE SCI, V65, P529, DOI 10.1007/s11427-021-1946-0
   Yang FL, 2021, BRIEF BIOINFORM, V22, DOI 10.1093/bib/bbab094
   Yang L, 2009, ANTIMICROB AGENTS CH, V53, P2432, DOI 10.1128/AAC.01283-08
   Zeng X, 2021, NUCLEIC ACIDS RES, V49, pD776, DOI 10.1093/nar/gkaa924
   Zhang QH, 2021, BRIEF BIOINFORM, V22, DOI 10.1093/bib/bbaa435
   Zhang RG, 2002, NATURE, V417, P971, DOI 10.1038/nature00833
   Zhang YF, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-18414-8
   Zhao RS, 2020, GASTROENTEROLOGY, V159, P969, DOI 10.1053/j.gastro.2020.05.004
   Zhao Y, 2021, BRIEF BIOINFORM, V22, DOI 10.1093/bib/bbaa158
   Zimmermann M, 2019, NATURE, V570, P462, DOI 10.1038/s41586-019-1291-3
NR 82
TC 2
Z9 2
U1 10
U2 23
PU SCIENCE PRESS
PI BEIJING
PA 16 DONGHUANGCHENGGEN NORTH ST, BEIJING 100717, PEOPLES R CHINA
SN 1674-7305
EI 1869-1889
J9 SCI CHINA LIFE SCI
JI Sci. China-Life Sci.
PD JAN
PY 2023
VL 66
IS 1
BP 137
EP 151
DI 10.1007/s11427-021-2121-0
EA AUG 2022
PG 15
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA 7T5ZZ
UT WOS:000836754100001
PM 35933489
DA 2023-06-08
ER

PT J
AU Moskalev, A
   Guvatova, Z
   Lopes, ID
   Beckett, CW
   Kennedy, BK
   De Magalhaes, JP
   Makarov, AA
AF Moskalev, Alexey
   Guvatova, Zulfiya
   Lopes, Ines De Almeida
   Beckett, Charles W.
   Kennedy, Brian K.
   De Magalhaes, Joao Pedro
   Makarov, Alexander A.
TI Targeting aging mechanisms: pharmacological perspectives
SO TRENDS IN ENDOCRINOLOGY AND METABOLISM
LA English
DT Review
ID LIFE-SPAN; MITOCHONDRIAL-FUNCTION; SENESCENT CELLS; GUT MICROBIOTA;
   METFORMIN; AGE; AUTOPHAGY; UROLITHIN; ELEGANS; MUSCLE
AB Geroprotectors slow down aging and promote healthy longevity in model animals. Although hundreds of compounds have been shown to extend the life of laboratory model organisms, clinical studies on potential geroprotectors are exceedingly rare, especially in healthy elders. This review aims to classify potential geroprotectors based on the mechanisms by which they influence aging. These pharmacological interventions can be classified into the following groups: those that prevent oxidation; proteostasis regulators; suppressors of genomic instability; epigenetic drugs; those that preserve mitochondrial function; inhibitors of aging-associated signaling pathways; hormetins; senolytics/senostatics; antiinflammatory drugs; antifibrotic agents; neurotrophic factors; factors preventing the impairment of barrier function; immunomodulators; and prebiotics, metabiotics, and enterosorbents.
C1 [Moskalev, Alexey; Guvatova, Zulfiya; Makarov, Alexander A.] Russian Acad Sci, Engelhardt Inst Mol Biol, Moscow 119991, Russia.
   [Moskalev, Alexey] Russian Acad Sci, Inst Biol, Fed Res Ctr, Komi Sci Ctr,Ural Branch, 28 Kommunisticheskaya St, Syktyvkar 167982, Russia.
   [Lopes, Ines De Almeida; Beckett, Charles W.; De Magalhaes, Joao Pedro] Univ Liverpool, Inst Ageing & Chron Dis, Integrat Genom Ageing Grp, Liverpool L7 8TX, Merseyside, England.
   [Kennedy, Brian K.] Natl Univ Singapore, Yong Loo Lin Sch Med, Hlth Longev Translat Res Program, Singapore, Singapore.
   [Kennedy, Brian K.] ASTAR, Ctr Hlth Longev, Natl Univ Hlth Syst, Singapore, Singapore.
   [Kennedy, Brian K.] ASTAR, Singapore Inst Clin Sci, Singapore, Singapore.
C3 Russian Academy of Sciences; Engelhardt Institute of Molecular Biology,
   RAS; Russian Academy of Sciences; Institute of Biology, Komi Scientific
   Centre, Ural Branch RAS; Komi Science Centre of the Ural Branch of the
   Russian Academy of Sciences; N8 Research Partnership; University of
   Liverpool; National University of Singapore; Agency for Science
   Technology & Research (A*STAR); National University of Singapore; Agency
   for Science Technology & Research (A*STAR); A*STAR - Singapore Institute
   for Clinical Sciences (SICS)
RP Moskalev, A; Makarov, AA (通讯作者)，Russian Acad Sci, Engelhardt Inst Mol Biol, Moscow 119991, Russia.; Moskalev, A (通讯作者)，Russian Acad Sci, Inst Biol, Fed Res Ctr, Komi Sci Ctr,Ural Branch, 28 Kommunisticheskaya St, Syktyvkar 167982, Russia.; De Magalhaes, JP (通讯作者)，Univ Liverpool, Inst Ageing & Chron Dis, Integrat Genom Ageing Grp, Liverpool L7 8TX, Merseyside, England.
EM amoskalev@list.ru; jp@senescence.info; aamakarov@eimb.ru
RI Moskalev, Alexey/H-4856-2013
OI Moskalev, Alexey/0000-0002-3248-1633; Beckett,
   Charles/0000-0003-4201-3451
FU Russian Science Foundation [19-74-30007]; Russian Science Foundation
   [19-74-30007] Funding Source: Russian Science Foundation
FX The work was supported by the Russian Science Foundation (grant
   19-74-30007) .
CR Abdelgadir Elamin, 2017, J Clin Med Res, V9, P388, DOI 10.14740/jocmr2922e
   Admasu TD, 2018, DEV CELL, V47, P67, DOI 10.1016/j.devcel.2018.09.001
   Ahmed K, 2019, FEBS LETT, V593, P1957, DOI 10.1002/1873-3468.13463
   Amano H, 2019, CELL METAB, V29, P1274, DOI 10.1016/j.cmet.2019.03.001
   Andreux PA, 2019, NAT METAB, V1, P595, DOI 10.1038/s42255-019-0073-4
   Aune D, 2018, AM J CLIN NUTR, V108, P1069, DOI 10.1093/ajcn/nqy097
   Barardo D, 2017, AGING CELL, V16, P594, DOI 10.1111/acel.12585
   Baselga J, 2009, J CLIN ONCOL, V27, P2630, DOI 10.1200/JCO.2008.18.8391
   Bharath LP, 2020, CELL METAB, V32, P44, DOI 10.1016/j.cmet.2020.04.015
   Bhukel A, 2017, AUTOPHAGY, V13, P444, DOI 10.1080/15548627.2016.1265193
   Biagi E, 2016, CURR BIOL, V26, P1480, DOI 10.1016/j.cub.2016.04.016
   Biradar SP, 2019, MITOCHONDRION, V46, P236, DOI 10.1016/j.mito.2018.07.003
   Bitto A, 2016, ELIFE, V5, DOI 10.7554/eLife.16351
   Boehme M, 2020, MOL PSYCHIATR, V25, P2567, DOI 10.1038/s41380-019-0425-1
   Cameron AR, 2018, REDOX BIOL, V14, P187, DOI 10.1016/j.redox.2017.08.018
   Carmona-Gutierrez D, 2016, AGEING RES REV, V32, P2, DOI 10.1016/j.arr.2016.04.009
   Barbosa MC, 2019, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00790
   Castillo-Quan JI, 2019, P NATL ACAD SCI USA, V116, P20817, DOI 10.1073/pnas.1913212116
   Castillo-Quan JI, 2016, CELL REP, V15, P638, DOI 10.1016/j.celrep.2016.03.041
   Cecco M, 2013, AGING CELL, V12, P247, DOI 10.1111/acel.12047
   Collard HR, 2010, AM J RESP CRIT CARE, V181, P771, DOI 10.1164/rccm.201001-0049ED
   Conze D, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-46120-z
   da Silva PFL, 2019, AGING CELL, V18, DOI 10.1111/acel.12848
   Dai H, 2018, PHARMACOL THERAPEUT, V188, P140, DOI 10.1016/j.pharmthera.2018.03.004
   Dang Y, 2020, AGING CELL, V19, DOI 10.1111/acel.13060
   Danilov A, 2013, ONCOTARGET, V4, P1507, DOI 10.18632/oncotarget.1272
   De Cecco M, 2019, NATURE, V572, pE5, DOI [10.1038/s41586-019-1350-9, 10.1038/s41586-018-0784-9]
   De Haes W, 2014, P NATL ACAD SCI USA, V111, pE2501, DOI 10.1073/pnas.1321776111
   Deblon N, 2012, BRIT J PHARMACOL, V165, P2325, DOI 10.1111/j.1476-5381.2011.01716.x
   Demarest TG, 2019, ANNU REV CANC BIOL, V3, P105, DOI 10.1146/annurev-cancerbio-030518-055905
   Desdin-Mico G, 2020, SCIENCE, V368, P1371, DOI 10.1126/science.aax0860
   Desilets AR, 2008, ANN PHARMACOTHER, V42, P817, DOI 10.1345/aph.1K656
   Ewald CY, 2015, NATURE, V519, P97, DOI 10.1038/nature14021
   Fahy GM, 2019, AGING CELL, V18, DOI 10.1111/acel.13028
   Fang EF, 2019, NAT NEUROSCI, V22, P401, DOI 10.1038/s41593-018-0332-9
   Fhayli W, 2019, CELL SIGNAL, V62, DOI 10.1016/j.cellsig.2019.05.018
   Forman HJ, 2021, NAT REV DRUG DISCOV, V20, P689, DOI 10.1038/s41573-021-00233-1
   Galluzzi L, 2017, NAT REV DRUG DISCOV, V16, P487, DOI 10.1038/nrd.2017.22
   Gensous N, 2020, GEROSCIENCE, V42, P687, DOI 10.1007/s11357-019-00149-0
   Gomez-Linton DR, 2019, BIOGERONTOLOGY, V20, P583, DOI 10.1007/s10522-019-09817-2
   Gorbunova V, 2021, NATURE, V596, P43, DOI 10.1038/s41586-021-03542-y
   Graney BA, 2018, PATIENT-RELAT OUTCOM, V9, P321, DOI 10.2147/PROM.S144425
   Guarda E, 2004, AM HEART J, V148, DOI 10.1016/j.ahj.2004.03.046
   Guvatova Z, 2020, MECH AGEING DEV, V189, DOI 10.1016/j.mad.2020.111260
   Hatami A, 2018, FEBS J, V285, P3002, DOI 10.1111/febs.14590
   Hickson LJ, 2019, EBIOMEDICINE, V47, P446, DOI 10.1016/j.ebiom.2019.08.069
   Jud P, 2019, DIABETES RES CLIN PR, V148, P54, DOI 10.1016/j.diabres.2018.11.016
   Justice JN, 2019, EBIOMEDICINE, V40, P554, DOI 10.1016/j.ebiom.2018.12.052
   Justice JN, 2018, GEROSCIENCE, V40, P419, DOI 10.1007/s11357-018-0042-y
   Kaeberlein M, 2018, GEROSCIENCE, V40, P361, DOI 10.1007/s11357-018-0036-9
   Kang C, 2019, MOL CELLS, V42, P821, DOI 10.14348/molcells.2019.0298
   Kellenberger E, 2011, BIOORG MED CHEM LETT, V21, P3939, DOI 10.1016/j.bmcl.2011.05.022
   Khaltourina D, 2020, MECH AGEING DEV, V189, DOI 10.1016/j.mad.2020.111230
   Khan SU, 2019, ANN INTERN MED, V171, P190, DOI 10.7326/M19-0341
   Kim Y, 2020, TRANSL PSYCHIAT, V10, DOI 10.1038/s41398-020-0838-2
   Koh JY, 2019, MOL BRAIN, V12, DOI 10.1186/s13041-019-0439-2
   Kolilekas L, 2019, EXPERT REV RESP MED, V13, P229, DOI 10.1080/17476348.2019.1568244
   Konopka AR, 2019, GEROSCIENCE, V41, P101, DOI 10.1007/s11357-019-00057-3
   Konopka AR, 2019, AGING CELL, V18, DOI 10.1111/acel.12880
   Lally MA, 2021, J AM MED DIR ASSOC, V22, P193, DOI 10.1016/j.jamda.2020.10.031
   Lashmanova E, 2017, FRONT PHARMACOL, V8, DOI 10.3389/fphar.2017.00884
   Leestemaker Y, 2017, CELL CHEM BIOL, V24, P725, DOI 10.1016/j.chembiol.2017.05.010
   Lewinska A, 2020, REDOX BIOL, V28, DOI 10.1016/j.redox.2019.101337
   Li GF, 2014, CLIN EXP PHARMACOL P, V41, P459, DOI 10.1111/1440-1681.12244
   Liguori I., 2018, CLIN INTERV AGING, V13, P757, DOI [10.2147/CIA.S158513, DOI 10.2147/CIA.S158513]
   Longo VD, 2003, EXP GERONTOL, V38, P807, DOI 10.1016/S0531-5565(03)00113-X
   Lv ZQ, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.00191
   Maddu N, 2015, IMMUNOPHARM IMMUNOT, V37, P111, DOI 10.3109/08923973.2014.998369
   Madeo F, 2019, AUTOPHAGY, V15, P165, DOI 10.1080/15548627.2018.1530929
   Manka P, 2019, DRUGS, V79, P903, DOI 10.1007/s40265-019-01126-9
   Mannick JB, 2018, SCI TRANSL MED, V10, DOI 10.1126/scitranslmed.aaq1564
   Mannick JB, 2014, SCI TRANSL MED, V6, DOI 10.1126/scitranslmed.3009892
   Matt SM, 2018, FRONT IMMUNOL, V9, DOI 10.3389/fimmu.2018.01832
   McIntyre RL, 2019, EMBO MOL MED, V11, DOI 10.15252/emmm.201809854
   Mehdipour M, 2019, AGING-US, V11, P5628, DOI 10.18632/aging.102148
   Milisav I, 2018, SUBCELL BIOCHEM, V90, P1, DOI 10.1007/978-981-13-2835-0_1
   Miller VJ, 2018, J NUTR METAB, V2018, DOI 10.1155/2018/5157645
   Mira L, 2002, FREE RADICAL RES, V36, P1199, DOI 10.1080/1071576021000016463
   Moskalev A, 2020, EXPERT OPIN DRUG DIS, V15, P135, DOI 10.1080/17460441.2020.1702965
   Moskalev A, 2017, AGING DIS, V8, P354, DOI 10.14336/AD.2016.1022
   Moskalev A, 2016, AGING CELL, V15, P407, DOI 10.1111/acel.12463
   Moskalev A, 2015, AGING-US, V7, P616, DOI 10.18632/aging.100799
   Moskalev AA, 2014, CELL CYCLE, V13, P1063, DOI 10.4161/cc.28433
   Nagai R, 2012, DIABETES, V61, P549, DOI 10.2337/db11-1120
   Ou JY, 2017, FOOD CHEM, V221, P1057, DOI 10.1016/j.foodchem.2016.11.056
   Pallauf K, 2017, P NUTR SOC, V76, P145, DOI 10.1017/S0029665116000720
   Palmeira CM, 2019, FREE RADICAL BIO MED, V141, P483, DOI 10.1016/j.freeradbiomed.2019.07.017
   Panigrahi M, 1996, BRAIN RES, V717, P184, DOI 10.1016/0006-8993(96)00009-1
   Panwar P, 2018, MATRIX BIOL, V65, P30, DOI 10.1016/j.matbio.2017.06.004
   Partridge L, 2020, NAT REV DRUG DISCOV, V19, P513, DOI 10.1038/s41573-020-0067-7
   Poddar SK, 2019, BIOMOLECULES, V9, DOI 10.3390/biom9010034
   Proshkina E, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9060529
   Qi ZM, 2021, AGING-US, V13, P1649, DOI 10.18632/aging.202512
   Quach A, 2017, AGING-US, V9, P419, DOI 10.18632/aging.101168
   Rabanal-Ruiz Y, 2017, ESSAYS BIOCHEM, V61, P565, DOI 10.1042/EBC20170027
   Rikans LE, 1997, BBA-MOL BASIS DIS, V1362, P116, DOI 10.1016/S0925-4439(97)00067-7
   Ryu D, 2016, NAT MED, V22, P879, DOI 10.1038/nm.4132
   Saez I, 2014, CURR GENOMICS, V15, P38, DOI 10.2174/138920291501140306113344
   Salmon AB, 2015, ONCOTARGET, V6, P2585, DOI 10.18632/oncotarget.3354
   Schafer MJ, 2017, NAT COMMUN, V8, DOI 10.1038/ncomms14532
   Schwalfenberg GK, 2017, J NUTR METAB, V2017, DOI 10.1155/2017/6254836
   Sharoff CG, 2010, AM J PHYSIOL-ENDOC M, V298, pE815, DOI 10.1152/ajpendo.00517.2009
   Shay JW, 2019, NAT REV GENET, V20, P299, DOI 10.1038/s41576-019-0099-1
   Shen PY, 2017, BIOFACTORS, V43, P379, DOI 10.1002/biof.1346
   Simon M, 2019, CELL METAB, V29, P871, DOI 10.1016/j.cmet.2019.02.014
   Singh N, 2018, FRONT MOL BIOSCI, V5, DOI 10.3389/fmolb.2018.00021
   Slack C, 2015, CELL, V162, P72, DOI 10.1016/j.cell.2015.06.023
   Tarantini S, 2019, REDOX BIOL, V24, DOI 10.1016/j.redox.2019.101192
   Til HP, 1997, FOOD CHEM TOXICOL, V35, P337, DOI 10.1016/S0278-6915(97)00121-X
   Toney AM, 2019, OBESITY, V27, P612, DOI 10.1002/oby.22404
   Toyama BH, 2013, NAT REV MOL CELL BIO, V14, P55, DOI 10.1038/nrm3496
   Trader DJ, 2017, BBA-GEN SUBJECTS, V1861, P892, DOI 10.1016/j.bbagen.2017.01.003
   Ustinova M, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0224835
   Vannuruswamy G, 2016, RSC ADV, V6, P65572, DOI 10.1039/c6ra11313c
   Wu XQ, 2018, J CANCER, V9, P2510, DOI 10.7150/jca.25324
   Yessenkyzy A, 2020, NUTRIENTS, V12, DOI 10.3390/nu12051344
   Zesiewicz T, 2018, MOVEMENT DISORD, V33, P1000, DOI 10.1002/mds.27353
   Zhang XY, 2017, DIABETES THER, V8, P293, DOI 10.1007/s13300-017-0226-y
   Zhang ZH, 2018, FRONT PHARMACOL, V9, DOI 10.3389/fphar.2018.01029
   Zhao HY, 2021, KOREAN J INTERN MED, V36, pS180, DOI 10.3904/kjim.2019.413
   Zhu XF, 2020, MOL MED, V26, DOI 10.1186/s10020-020-0136-8
   Zhu Y, 2015, AGING CELL, V14, P644, DOI 10.1111/acel.12344
   Zirnniak P, 2011, FREE RADICAL BIO MED, V51, P1087, DOI 10.1016/j.freeradbiomed.2011.05.039
NR 123
TC 13
Z9 13
U1 5
U2 27
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 1043-2760
EI 1879-3061
J9 TRENDS ENDOCRIN MET
JI Trends Endocrinol. Metab.
PD APR
PY 2022
VL 33
IS 4
BP 266
EP 280
DI 10.1016/j.tem.2022.01.007
EA MAR 2022
PG 15
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA ZQ6CC
UT WOS:000767189700004
PM 35183431
DA 2023-06-08
ER

PT J
AU Svegliati-Baroni, G
   Patricio, B
   Lioci, G
   Macedo, MP
   Gastaldelli, A
AF Svegliati-Baroni, Gianluca
   Patricio, Barbara
   Lioci, Gessica
   Macedo, Maria Paula
   Gastaldelli, Amalia
TI Gut-Pancreas-Liver Axis as a Target for Treatment of NAFLD/NASH
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE non-alcoholic fatty liver disease; non-alcoholic steatohepatitis; type-2
   diabetes; gut-pancreas-liver axis; incretins; lipid metabolism; glucose
   metabolism
ID NONALCOHOLIC FATTY LIVER; GLUCAGON-LIKE PEPTIDE-1; GASTRIC-INHIBITORY
   POLYPEPTIDE; TYPE-2 DIABETES-MELLITUS; BETA-CELL FUNCTION;
   METFORMIN-TREATED PATIENTS; COTRANSPORTER 2 INHIBITOR;
   PLACEBO-CONTROLLED TRIAL; GLP-1 RECEPTOR AGONIST; DIET-INDUCED OBESITY
AB Non-alcoholic fatty liver disease (NAFLD) represents the most common form of chronic liver disease worldwide. Due to its association with obesity and diabetes and the fall in hepatitis C virus morbidity, cirrhosis in NAFLD is becoming the most frequent indication to liver transplantation, but the pathogenetic mechanisms are still not completely understood. The so-called gut-liver axis has gained enormous interest when data showed that its alteration can lead to NAFLD development and might favor the occurrence of non-alcoholic steatohepatitis (NASH). Moreover, several therapeutic approaches targeting the gut-pancreas-liver axis, e.g., incretins, showed promising results in NASH treatment. In this review, we describe the role of incretin hormones in NAFLD/NASH pathogenesis and treatment and how metagenomic/metabolomic alterations in the gut microbiota can lead to NASH in the presence of gut barrier modifications favoring the passage of bacteria or bacterial products in the portal circulation, i.e., bacterial translocation.
C1 [Svegliati-Baroni, Gianluca] Osped Riuniti Ancona, Liver Injury & Transplant Unit, I-60020 Ancona, Italy.
   [Svegliati-Baroni, Gianluca] Polytech Univ Marche, Obes Ctr, I-60121 Ancona, Italy.
   [Patricio, Barbara; Gastaldelli, Amalia] CNR, Cardiometab Risk Unit, Inst Clin Physiol, I-56124 Pisa, Italy.
   [Patricio, Barbara; Gastaldelli, Amalia] St Anna Sch Adv Studies, Inst Life Sci, I-56127 Pisa, Italy.
   [Patricio, Barbara; Macedo, Maria Paula] APDP Diabet Portugal Educ & Res Ctr APDP ERC, P-1250189 Lisbon, Portugal.
   [Lioci, Gessica] Polytech Univ Marche, Dept Gastroenterol, I-60121 Ancona, Italy.
   [Macedo, Maria Paula] Univ Nova Lisboa, Fac Ciencias Med, CEDOC, NOVA Med Sch, P-1150082 Lisbon, Portugal.
   [Macedo, Maria Paula] Univ Aveiro, Inst Biomed iBiMED, Dept Med Sci, P-3810193 Aveiro, Portugal.
C3 Marche Polytechnic University; Consiglio Nazionale delle Ricerche (CNR);
   Istituto di Fisiologia Clinica (IFC-CNR); Scuola Superiore Sant'Anna;
   Marche Polytechnic University; Universidade Nova de Lisboa; Universidade
   de Aveiro
RP Gastaldelli, A (通讯作者)，CNR, Cardiometab Risk Unit, Inst Clin Physiol, I-56124 Pisa, Italy.; Gastaldelli, A (通讯作者)，St Anna Sch Adv Studies, Inst Life Sci, I-56127 Pisa, Italy.; Macedo, MP (通讯作者)，APDP Diabet Portugal Educ & Res Ctr APDP ERC, P-1250189 Lisbon, Portugal.; Macedo, MP (通讯作者)，Univ Nova Lisboa, Fac Ciencias Med, CEDOC, NOVA Med Sch, P-1150082 Lisbon, Portugal.; Macedo, MP (通讯作者)，Univ Aveiro, Inst Biomed iBiMED, Dept Med Sci, P-3810193 Aveiro, Portugal.
EM gsvegliati@gmail.com; barbara_patricio@ifc.cnr.it;
   gessicalioci@gmail.com; paula.macedo@nms.unl.pt; amalia@ifc.cnr.it
RI Gastaldelli, Amalia/H-3319-2014
OI Gastaldelli, Amalia/0000-0003-2594-1651; Patricio,
   Barbara/0000-0002-2418-4540; Macedo, Maria Paula/0000-0002-2549-0275
FU Italian National Research Council (CNR) [B54I19000370005]; European
   Union's Horizon 2020 Research and Innovation Programme under the Marie
   Sklodowska-Curie Grant [722619, 734719]; Early Stage Researcher grant
   under the FOIE GRAS project; iNOVA4Health [UID/Multi/04462/2013]; 
   [PTDC/BIM-MET/2115/2014];  [PTDC/MEC-MET/29314/2017]; Fundação para a
   Ciência e a Tecnologia [PTDC/MEC-MET/29314/2017] Funding Source: FCT
FX This study was supported by internal funds of the Italian National
   Research Council (CNR, B54I19000370005). M.P.M. and A.G. acknowledge the
   financial support from the European Union's Horizon 2020 Research and
   Innovation Programme under the Marie Sklodowska-Curie Grant Agreement
   No. 722619 (FOIE GRAS project) and Grant Agreement No. 734719 (mtFOIE
   GRAS project), and BP is recipient of an Early Stage Researcher grant
   under the FOIE GRAS project. M.P.M. also acknowledge the financial
   support from PTDC/BIM-MET/2115/2014 and PTDC/MEC-MET/29314/2017; and
   iNOVA4Health (UID/Multi/04462/2013).
CR Acton JJ, 2009, J MED CHEM, V52, P3846, DOI 10.1021/jm900097m
   Ambery P, 2018, LANCET, V391, P2607, DOI 10.1016/S0140-6736(18)30726-8
   [Anonymous], 2020, COMPL RESP LETT FDA
   Arab JP, 2017, HEPATOLOGY, V65, P350, DOI 10.1002/hep.28709
   Armstrong MJ, 2013, ALIMENT PHARM THER, V37, P234, DOI 10.1111/apt.12149
   Armstrong MJ, 2016, J HEPATOL, V64, P399, DOI 10.1016/j.jhep.2015.08.038
   Armstrong MJ, 2016, LANCET, V387, P679, DOI 10.1016/S0140-6736(15)00803-X
   Asmar M, 2010, DIABETES, V59, P2160, DOI 10.2337/db10-0098
   Bailey CJ, 2010, LANCET, V375, P2223, DOI 10.1016/S0140-6736(10)60407-2
   Bajaj JS, 2018, HEPATOLOGY, V68, P234, DOI 10.1002/hep.29791
   Balaban YH, 2007, ANN HEPATOL, V6, P242, DOI 10.1016/S1665-2681(19)31905-2
   Bando Y, 2017, DIABETOL INT, V8, P218, DOI 10.1007/s13340-016-0302-y
   Bardella MT, 2004, DIGEST LIVER DIS, V36, P333, DOI 10.1016/j.dld.2004.01.012
   Bashiardes S, 2016, MOL METAB, V5, P782, DOI 10.1016/j.molmet.2016.06.003
   Bedossa P, 2017, GUT, V66, P1688, DOI 10.1136/gutjnl-2016-312238
   Belfort R, 2006, NEW ENGL J MED, V355, P2297, DOI 10.1056/NEJMoa060326
   Belfort R, 2010, J CLIN ENDOCR METAB, V95, P829, DOI 10.1210/jc.2009-1487
   Ben-Shlomo S, 2011, J HEPATOL, V54, P1214, DOI 10.1016/j.jhep.2010.09.032
   Bergenstal RM, 2013, DIABETES OBES METAB, V15, P264, DOI 10.1111/dom.12026
   Bi Y, 2014, ACTA DIABETOL, V51, P865, DOI 10.1007/s00592-014-0638-3
   Blaslov K, 2014, CLIN RES HEPATOL GAS, V38, pE59, DOI 10.1016/j.clinre.2013.10.013
   Boubia B, 2018, J MED CHEM, V61, P2246, DOI 10.1021/acs.jmedchem.7b01285
   Boursier J, 2016, HEPATOLOGY, V63, P764, DOI 10.1002/hep.28356
   Brandt SJ, 2018, J INTERN MED, V284, P581, DOI 10.1111/joim.12837
   Brandt SJ, 2018, PEPTIDES, V100, P190, DOI 10.1016/j.peptides.2017.12.021
   Bril F, 2018, CLIN GASTROENTEROL H, V16, P558, DOI 10.1016/j.cgh.2017.12.001
   Bunck MC, 2011, DIABETES CARE, V34, P2041, DOI 10.2337/dc11-0291
   Buse JB, 2007, CLIN THER, V29, P139, DOI 10.1016/j.clinthera.2007.01.015
   Buse JB, 2013, LANCET, V381, P117, DOI 10.1016/S0140-6736(12)61267-7
   Calle R, 2019, J HEPATOL, V70, pE69, DOI 10.1016/S0618-8278(19)30122-7
   Camastra S, 2017, DIABETES OBES METAB, V19, P412, DOI 10.1111/dom.12836
   Campbell JE, 2013, CELL METAB, V17, P819, DOI 10.1016/j.cmet.2013.04.008
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Cani PD, 2018, GUT, V67, P1716, DOI 10.1136/gutjnl-2018-316723
   CARLSON MG, 1993, J CLIN ENDOCR METAB, V77, P11, DOI 10.1210/jc.77.1.11
   Carpino G, 2020, HEPATOLOGY, V72, P470, DOI 10.1002/hep.31056
   Cersosimo E, 2011, J CLIN ENDOCR METAB, V96, P1763, DOI 10.1210/jc.2010-2146
   Charles ED, 2019, OBESITY, V27, P41, DOI 10.1002/oby.22344
   Cheng CW, 2018, LIFE SCI, V209, P157, DOI 10.1016/j.lfs.2018.08.017
   Choi IY, 2018, DIABETES, V67, DOI 10.2337/db18-1106-P
   Choi JD, 2019, DIABETES, V68, DOI 10.2337/db19-982-P
   Choi J, 2020, DIABETES, V69, DOI 10.2337/db20-1830-P
   Chu HK, 2019, GUT, V68, P359, DOI 10.1136/gutjnl-2018-316307
   Clemmensen C, 2014, DIABETES, V63, P1422, DOI 10.2337/db13-1609
   Colca JR, 2018, EXPERT OPIN INV DRUG, V27, P631, DOI 10.1080/13543784.2018.1494153
   Corpechot C, 2018, NEW ENGL J MED, V378, P2171, DOI 10.1056/NEJMoa1714519
   Csak T, 2011, AM J PHYSIOL-GASTR L, V300, pG433, DOI 10.1152/ajpgi.00163.2009
   Cui J, 2016, J HEPATOL, V65, P369, DOI 10.1016/j.jhep.2016.04.021
   Cusi K, 2018, DIABETIC MED, V35, P1434, DOI 10.1111/dme.13697
   Cusi K, 2019, DIABETES OBES METAB, V21, P812, DOI 10.1111/dom.13584
   Cusi K, 2016, ANN INTERN MED, V165, P305, DOI 10.7326/M15-1774
   Cuthbertson DJ, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0050117
   Damms-Machado A, 2017, AM J CLIN NUTR, V105, P127, DOI 10.3945/ajcn.116.131110
   Daniele G, 2015, DIABETES, V64, P3406, DOI 10.2337/db14-1718
   Dao MC, 2016, GUT, V65, P426, DOI 10.1136/gutjnl-2014-308778
   Dapito DH, 2012, CANCER CELL, V21, P504, DOI 10.1016/j.ccr.2012.02.007
   David LA, 2014, NATURE, V505, P559, DOI 10.1038/nature12820
   Davis BC, 2017, SEMIN LIVER DIS, V37, P128, DOI 10.1055/s-0037-1602763
   DAY AP, 1993, METABOLISM, V42, P839, DOI 10.1016/0026-0495(93)90056-T
   Day CP, 1998, GASTROENTEROLOGY, V114, P842, DOI 10.1016/S0016-5085(98)70599-2
   Day JW, 2012, BIOPOLYMERS, V98, P443, DOI 10.1002/bip.22072
   Day JW, 2009, NAT CHEM BIOL, V5, P749, DOI 10.1038/nchembio.209
   de la Cuesta-Zuluaga J, 2017, DIABETES CARE, V40, P54, DOI 10.2337/dc16-1324
   De Minicis S, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0097136
   DeMinicis S, 2014, HEPATOLOGY, V59, P1738, DOI 10.1002/hep.26695
   DeFronzo RA, 2008, CURR MED RES OPIN, V24, P2943, DOI [10.1185/03007990802418851, 10.1185/03007990802418851 ]
   DeFronzo RA, 2010, DIABETES CARE, V33, P951, DOI [10.2337/dc09-1521, 10.2337/dc10-0646]
   Degirolamo C, 2015, HEPATOLOGY, V61, P161, DOI 10.1002/hep.27274
   Del Chierico F, 2017, HEPATOLOGY, V65, P451, DOI 10.1002/hep.28572
   den Besten G, 2013, J LIPID RES, V54, P2325, DOI 10.1194/jlr.R036012
   Depaoli A, 2019, DIABETES, V68, DOI 10.2337/db19-140-LB
   DePaoli A, 2019, J HEPATOL, V70, pE68, DOI 10.1016/S0618-8278(19)30120-3
   DePaoli AM, 2019, DIABETES, V68, P1315, DOI 10.2337/db18-1305
   DePaoli AM, 2014, DIABETES CARE, V37, P1918, DOI 10.2337/dc13-2480
   Depommier C, 2019, NAT MED, V25, P1096, DOI 10.1038/s41591-019-0495-2
   Ding XK, 2006, HEPATOLOGY, V43, P173, DOI 10.1002/hep.21006
   Dixon LJ, 2013, COMPR PHYSIOL, V3, P785, DOI 10.1002/cphy.c120026
   Donaldson GP, 2016, NAT REV MICROBIOL, V14, P20, DOI 10.1038/nrmicro3552
   Dong YJ, 2017, CLIN RES HEPATOL GAS, V41, P284, DOI 10.1016/j.clinre.2016.11.009
   Drucker DJ, 2006, LANCET, V368, P1696, DOI 10.1016/S0140-6736(06)69705-5
   Duarte N, 2018, HEPATOL COMMUN, V2, P1080, DOI 10.1002/hep4.1225
   Duarte N, 2015, BIOMED RES INT, V2015, DOI 10.1155/2015/984578
   DUPRE J, 1973, J CLIN ENDOCR METAB, V37, P826, DOI 10.1210/jcem-37-5-826
   Eguchi Y, 2015, HEPATOL RES, V45, P269, DOI 10.1111/hepr.12351
   Eriksson JW, 2018, DIABETOLOGIA, V61, P1923, DOI 10.1007/s00125-018-4675-2
   Fan H, 2013, ARQ BRAS ENDOCRINOL, V57, P702, DOI 10.1590/S0004-27302013000900005
   Fang S, 2015, NAT MED, V21, P159, DOI 10.1038/nm.3760
   Fasano A, 2000, ANN NY ACAD SCI, V915, P214
   Fasano A, 2012, CLIN GASTROENTEROL H, V10, P1096, DOI 10.1016/j.cgh.2012.08.012
   Fava GE, 2016, J DIABETES COMPLICAT, V30, P1651, DOI 10.1016/j.jdiacomp.2016.05.016
   Feng WH, 2017, J DIABETES, V9, P800, DOI 10.1111/1753-0407.12555
   Fernandez-Miranda C, 2008, DIGEST LIVER DIS, V40, P200, DOI 10.1016/j.dld.2007.10.002
   Fickert P, 2009, AM J PATHOL, V175, P2392, DOI 10.2353/ajpath.2009.090114
   Finan B, 2015, NAT MED, V21, P27, DOI 10.1038/nm.3761
   Firneisz G, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0012226
   Flint A, 1998, J CLIN INVEST, V101, P515, DOI 10.1172/JCI990
   Flint HJ, 2012, NAT REV GASTRO HEPAT, V9, P577, DOI 10.1038/nrgastro.2012.156
   Frias JP, 2020, DIABETES OBES METAB, V22, P938, DOI 10.1111/dom.13979
   Frias JP, 2018, LANCET, V392, P2180, DOI 10.1016/S0140-6736(18)32260-8
   Frias JP, 2017, CELL METAB, V26, P343, DOI 10.1016/j.cmet.2017.07.011
   Fuchs CD, 2016, SEMIN LIVER DIS, V36, P69, DOI 10.1055/s-0036-1571296
   Fuchs M, 2012, J HEPATOL, V56, P291, DOI 10.1016/j.jhep.2011.05.019
   Gao JH, 2016, AM J PHYSIOL-GASTR L, V310, pG962, DOI 10.1152/ajpgi.00428.2015
   Gasbjerg LS, 2019, DIABETES, V68, P906, DOI 10.2337/db18-1123
   Gastaldelli A, 2020, DIABETES OBES METAB, V22, P393, DOI 10.1111/dom.13907
   Gastaldelli A, 2016, HEPATOLOGY, V64, P2028, DOI 10.1002/hep.28827
   GERICH JE, 1976, J CLIN INVEST, V57, P875, DOI 10.1172/JCI108364
   Giorgio V, 2014, DIGEST LIVER DIS, V46, P556, DOI 10.1016/j.dld.2014.02.010
   Gluud LL, 2014, BMJ OPEN, V4, DOI 10.1136/bmjopen-2014-005325
   Graziani C, 2019, EUR REV MED PHARMACO, V23, P795, DOI 10.26355/eurrev_201901_16894
   Grimm M, 2013, POSTGRAD MED, V125, DOI 10.3810/pgm.2013.05.2660
   Gupta NA, 2012, AM J PATHOL, V181, P1693, DOI 10.1016/j.ajpath.2012.07.015
   Gupta NA, 2010, HEPATOLOGY, V51, P1584, DOI 10.1002/hep.23569
   Han E, 2020, J CLIN MED, V9, DOI 10.3390/jcm9010259
   Harrison SA, 2019, LANCET, V394, P2012, DOI 10.1016/S0140-6736(19)32517-6
   Harrison SA, 2020, J HEPATOL, V72, P613, DOI 10.1016/j.jhep.2019.10.023
   Harrison SA, 2020, HEPATOLOGY, V71, P1198, DOI 10.1002/hep.30590
   Harrison SA, 2018, LANCET, V391, P1174, DOI 10.1016/S0140-6736(18)30474-4
   Hartman ML, 2020, DIABETES CARE, V43, P1352, DOI 10.2337/dc19-1892
   He YL, 2019, DIABETES OBES METAB, V21, P1311, DOI 10.1111/dom.13654
   Heise T, 2014, DIABETES OBES METAB, V16, P1070, DOI 10.1111/dom.12317
   Henao-Mejia J, 2012, NATURE, V482, P179, DOI 10.1038/nature10809
   Henderson SJ, 2016, DIABETES OBES METAB, V18, P1176, DOI 10.1111/dom.12735
   Hermansen K, 2013, DIABETES OBES METAB, V15, P1040, DOI 10.1111/dom.12133
   HERRMANN C, 1995, DIGESTION, V56, P117, DOI 10.1159/000201231
   Hershkovitz O., 2013, P END SOC 95 ANN M E
   Hirschfield GM, 2019, J HEPATOL, V70, P483, DOI 10.1016/j.jhep.2018.10.035
   Hoist JJ, 2019, METABOLISM, V96, P46, DOI 10.1016/j.metabol.2019.04.014
   Holst JJ, 2006, DIABETOLOGIA, V49, P253, DOI 10.1007/s00125-005-0107-1
   Hoyles L, 2018, NAT MED, V24, P1070, DOI 10.1038/s41591-018-0061-3
   Human Microbiome Project Consortium, 2012, Nature, V486, P207, DOI 10.1038/nature11234
   Ida S, 2019, CARDIOVASC DIABETOL, V18, DOI 10.1186/s12933-019-0845-x
   Iepsen EW, 2016, EUR J ENDOCRINOL, V174, P775, DOI 10.1530/EJE-15-1116
   Inoue M, 2019, J DIABETES INVEST, V10, P1004, DOI 10.1111/jdi.12980
   Irene P, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-11744-6
   Iruarrizaga-Lejarreta M, 2017, HEPATOL COMMUN, V1, P911, DOI 10.1002/hep4.1107
   Itani T, 2018, OBES SCI PRACT, V4, P477, DOI 10.1002/osp4.294
   Ito D, 2017, DIABETES CARE, V40, P1364, DOI 10.2337/dc17-0518
   Jall S, 2017, MOL METAB, V6, P440, DOI 10.1016/j.molmet.2017.02.002
   Jendle J, 2009, DIABETES OBES METAB, V11, P1163, DOI 10.1111/j.1463-1326.2009.01158.x
   Jia W, 2018, NAT REV GASTRO HEPAT, V15, P111, DOI 10.1038/nrgastro.2017.119
   Jiang CT, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms10166
   Jiang CT, 2015, J CLIN INVEST, V125, P386, DOI 10.1172/JCI76738
   Joy TR, 2017, WORLD J GASTROENTERO, V23, P141, DOI 10.3748/wjg.v23.i1.141
   Kahl S, 2020, DIABETES CARE, V43, P298, DOI 10.2337/dc19-0641
   KARHAPAA P, 1992, CLIN PHARMACOL THER, V52, P620, DOI 10.1038/clpt.1992.200
   Kaul U, 2019, CARDIOVASC DIABETOL, V18, DOI 10.1186/s12933-019-0884-3
   Kenny PR, 2010, AM J GASTROENTEROL, V105, P2707, DOI 10.1038/ajg.2010.363
   Khoo J, 2017, DIABETES OBES METAB, V19, P1814, DOI 10.1111/dom.13007
   KIKUCHI M, 1988, ARCH BIOCHEM BIOPHYS, V266, P369, DOI 10.1016/0003-9861(88)90268-8
   Kliewer SA, 2015, DIGEST DIS, V33, P327, DOI 10.1159/000371670
   Klonoff DC, 2008, CURR MED RES OPIN, V24, P275, DOI 10.1185/030079908X253870
   KREYMANN B, 1987, LANCET, V2, P1300
   Kuchay MS, 2018, DIABETES CARE, V41, P1801, DOI 10.2337/dc18-0165
   Lai LL, 2020, DIGEST DIS SCI, V65, P623, DOI 10.1007/s10620-019-5477-1
   Lawitz EJ, 2018, CLIN GASTROENTEROL H, V16, P1983, DOI 10.1016/j.cgh.2018.04.042
   Leclercq S, 2014, P NATL ACAD SCI USA, V111, pE4485, DOI 10.1073/pnas.1415174111
   Lee DM, 2018, CARDIOVASC DIABETOL, V17, DOI 10.1186/s12933-018-0708-x
   Lee PCH, 2018, DIABETES THER, V9, P285, DOI 10.1007/s13300-017-0355-3
   Lee YS, 2012, DIABETOLOGIA, V55, P2456, DOI 10.1007/s00125-012-2592-3
   Lee YH, 2017, J KOREAN MED SCI, V32, P60, DOI 10.3346/jkms.2017.32.1.60
   Leiter LA, 2016, DIABETES METAB, V42, P25, DOI 10.1016/j.diabet.2015.10.003
   Leroux A, 2012, J HEPATOL, V57, P141, DOI 10.1016/j.jhep.2012.02.028
   Leung C, 2016, NAT REV GASTRO HEPAT, V13, P412, DOI 10.1038/nrgastro.2016.85
   Li BY, 2018, J PHARM PHARM SCI, V21, P222, DOI 10.18433/jpps29831
   Liu J, 2019, DIABETES VASC DIS RE, V16, P415, DOI 10.1177/1479164119842513
   Liu L, 2020, DIABETES-METAB RES, V36, DOI 10.1002/dmrr.3292
   Llorente C, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-00796-x
   Loomba R, 2017, CELL METAB, V25, P1054, DOI 10.1016/j.cmet.2017.04.001
   Lucas KJ, 2020, DIGEST LIVER DIS, V52, pE38, DOI 10.1016/j.dld.2019.12.129
   Luther J, 2015, CELL MOL GASTROENTER, V1, P222, DOI 10.1016/j.jcmgh.2015.01.001
   Machida K, 2009, P NATL ACAD SCI USA, V106, P1548, DOI 10.1073/pnas.0807390106
   Marra F, 2018, J HEPATOL, V68, P280, DOI 10.1016/j.jhep.2017.11.014
   Matikainen N, 2006, DIABETOLOGIA, V49, P2049, DOI 10.1007/s00125-006-0340-2
   Matikainen N, 2019, DIABETES OBES METAB, V21, P84, DOI 10.1111/dom.13487
   McCaughan GW, 2000, IMMUNOL REV, V174, P172, DOI 10.1034/j.1600-0528.2002.017420.x
   Meier JJ, 2003, DIABETOLOGIA, V46, P798, DOI 10.1007/s00125-003-1103-y
   Meli R, 2014, FRONT IMMUNOL, V5, P1, DOI 10.3389/fimmu.2014.00177
   Mentzel S, 1996, J HISTOCHEM CYTOCHEM, V44, P445, DOI 10.1177/44.5.8627002
   Miele L, 2009, HEPATOLOGY, V49, P1877, DOI 10.1002/hep.22848
   Miura K, 2014, WORLD J GASTROENTERO, V20, P7381, DOI 10.3748/wjg.v20.i23.7381
   Miura K, 2010, GASTROENTEROLOGY, V139, P323, DOI 10.1053/j.gastro.2010.03.052
   Miura S, 2012, BMC CANCER, V12, DOI 10.1186/1471-2407-12-56
   Miyake T, 2018, OPEN MED-WARSAW, V13, P402, DOI 10.1515/med-2018-0059
   Miyazaki M, 2012, MOL MED REP, V5, P729, DOI 10.3892/mmr.2011.707
   Mouries J, 2019, J HEPATOL, V71, P1216, DOI 10.1016/j.jhep.2019.08.005
   Mouzaki M, 2013, HEPATOLOGY, V58, P120, DOI 10.1002/hep.26319
   Mridha AR, 2017, J HEPATOL, V66, P1037, DOI 10.1016/j.jhep.2017.01.022
   Mudaliar S, 2013, GASTROENTEROLOGY, V145, P574, DOI 10.1053/j.gastro.2013.05.042
   Mulvihill EE, 2017, CELL METAB, V25, P152, DOI 10.1016/j.cmet.2016.10.007
   Muscogiuri G, 2017, TRENDS ENDOCRIN MET, V28, P88, DOI 10.1016/j.tem.2016.10.001
   Nauck M, 2013, DIABETES OBES METAB, V15, P204, DOI 10.1111/dom.12012
   Nauck MA, 2002, J CLIN ENDOCR METAB, V87, P1239, DOI 10.1210/jc.87.3.1239
   Nauck MA, 1996, DIABETOLOGIA, V39, P1546, DOI 10.1007/s001250050613
   NAUCK MA, 1993, J CLIN INVEST, V91, P301, DOI 10.1172/JCI116186
   NAUCK MA, 1993, J CLIN ENDOCR METAB, V76, P912, DOI 10.1210/jc.76.4.912
   Nauck MA, 2016, LANCET DIABETES ENDO, V4, P525, DOI 10.1016/S2213-8587(15)00482-9
   Neish AS, 2009, GASTROENTEROLOGY, V136, P65, DOI 10.1053/j.gastro.2008.10.080
   Neuschwander-Tetri BA, 2015, LANCET, V385, P956, DOI 10.1016/S0140-6736(14)61933-4
   Newsome P, 2019, ALIMENT PHARM THER, V50, P193, DOI 10.1111/apt.15316
   Nicholes K, 2002, AM J PATHOL, V160, P2295, DOI 10.1016/S0002-9440(10)61177-7
   Nicholson JK, 2012, SCIENCE, V336, P1262, DOI 10.1126/science.1223813
   Ohki T, 2016, CLIN DRUG INVEST, V36, P313, DOI 10.1007/s40261-016-0383-1
   Ohki T, 2012, SCI WORLD J, DOI 10.1100/2012/496453
   Ohta A, 2017, EXPERT OPIN PHARMACO, V18, P1433, DOI 10.1080/14656566.2017.1363888
   Olivares M, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.01900
   Ozaki A, 2020, CONT CLIN TRIAL COMM, V17, DOI 10.1016/j.conctc.2019.100516
   Parker HE, 2010, EXPERT REV MOL MED, V12, DOI 10.1017/S146239940900132X
   Parker VER, 2020, J CLIN ENDOCR METAB, V105, P803, DOI 10.1210/clinem/dgz047
   Parlevliet ET, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0049152
   Patel K, 2020, HEPATOLOGY, V72, P58, DOI 10.1002/hep.31205
   Patel Vishal, 2018, Cardiovascular & Hematological Agents in Medicinal Chemistry, V16, P35, DOI 10.2174/1871525716666180118152158
   Pathak P, 2018, HEPATOLOGY, V68, P1574, DOI 10.1002/hep.29857
   Pearce SC, 2018, BMC BIOL, V16, DOI 10.1186/s12915-018-0481-z
   Petit JM, 2017, J CLIN ENDOCR METAB, V102, P407, DOI 10.1210/jc.2016-2775
   Plovier H, 2017, NAT MED, V23, P107, DOI 10.1038/nm.4236
   Pocai A, 2009, DIABETES, V58, P2258, DOI 10.2337/db09-0278
   Ponziani FR, 2019, HEPATOLOGY, V69, P107, DOI 10.1002/hep.30036
   Prigeon RL, 2003, AM J PHYSIOL-ENDOC M, V285, pE701, DOI 10.1152/ajpendo.00024.2003
   Puri P, 2018, HEPATOLOGY, V67, P534, DOI 10.1002/hep.29359
   Pyke C, 2014, ENDOCRINOLOGY, V155, P1280, DOI 10.1210/en.2013-1934
   Ratziu V, 2016, GASTROENTEROLOGY, V150, P1147, DOI 10.1053/j.gastro.2016.01.038
   Reilly NR, 2015, J HEPATOL, V62, P1405, DOI 10.1016/j.jhep.2015.01.013
   Rinella ME, 2019, J HEPATOL, V70, P735, DOI 10.1016/j.jhep.2018.11.032
   Rosenstock M, 2019, J HEPATOL, V70, pE155, DOI 10.1016/S0618-8278(19)30274-9
   Roy S, 2019, CUREUS, V11, DOI 10.7759/cureus.6361
   Safadi R, 2014, CLIN GASTROENTEROL H, V12, P2085, DOI 10.1016/j.cgh.2014.04.038
   Samson SL, 2011, DIABETOLOGIA, V54, P3093, DOI 10.1007/s00125-011-2317-z
   Samson SL, 2008, MOL THER, V16, P1805, DOI 10.1038/mt.2008.198
   Sanchez-Garrido MA, 2017, DIABETOLOGIA, V60, P1851, DOI 10.1007/s00125-017-4354-8
   Sandler NG, 2011, GASTROENTEROLOGY, V141, P1220, DOI 10.1053/j.gastro.2011.06.063
   Sanyal A, 2018, LANCET, V392, P2705, DOI 10.1016/S0140-6736(18)31785-9
   Sanyal AJ, 2010, NEW ENGL J MED, V362, P1675, DOI 10.1056/NEJMoa0907929
   Sathyanarayana P, 2011, OBESITY, V19, P2310, DOI 10.1038/oby.2011.152
   SCHEPPACH W, 1994, GUT, V35, pS35, DOI 10.1136/gut.35.1_Suppl.S35
   Schmitt C, 2017, DIABETES OBES METAB, V19, P1436, DOI 10.1111/dom.13024
   Schwartz EA, 2010, ATHEROSCLEROSIS, V212, P217, DOI 10.1016/j.atherosclerosis.2010.05.028
   Seghieri M, 2013, DIABETOLOGIA, V56, P156, DOI 10.1007/s00125-012-2738-3
   Seghieri M, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00649
   Seko Y, 2018, DIABET METAB SYND OB, V11, P835, DOI 10.2147/DMSO.S184767
   Seko Y, 2017, HEPATOL RES, V47, P1206, DOI 10.1111/hepr.12837
   Seko Y, 2017, HEPATOL RES, V47, P1072, DOI 10.1111/hepr.12834
   Seo D, 2017, NUCL MED BIOL, V49, P57, DOI 10.1016/j.nucmedbio.2017.03.002
   Shao N, 2014, DIABETES-METAB RES, V30, P521, DOI 10.1002/dmrr.2561
   Sharma S, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0025269
   Shibuya T, 2018, DIABETES OBES METAB, V20, P438, DOI 10.1111/dom.13061
   Shirakawa J, 2011, DIABETES, V60, P1246, DOI 10.2337/db10-1338
   Skarbaliene J, 2017, J HEPATOL, V66, pS102, DOI 10.1016/S0168-8278(17)30466-X
   Smits MM, 2016, DIABETOLOGIA, V59, P2588, DOI 10.1007/s00125-016-4100-7
   Sommer F, 2013, NAT REV MICROBIOL, V11, P227, DOI 10.1038/nrmicro2974
   Souto KP, 2018, SURG OBES RELAT DIS, V14, P66, DOI 10.1016/j.soard.2017.09.527
   Stefan N, 2014, LANCET DIABETES ENDO, V2, P406, DOI 10.1016/S2213-8587(13)70170-0
   Stienstra R, 2011, P NATL ACAD SCI USA, V108, P15324, DOI 10.1073/pnas.1100255108
   Sturgeon C, 2017, ANN NY ACAD SCI, V1397, P130, DOI 10.1111/nyas.13343
   Suez J, 2018, CELL, V174, P1406, DOI 10.1016/j.cell.2018.08.047
   Sumida Y, 2019, HEPATOL RES, V49, P64, DOI 10.1111/hepr.13236
   Sun EWL, 2019, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00754
   Suzuki D, 2013, INTERNAL MED, V52, P1029, DOI 10.2169/internalmedicine.52.8961
   Svegliati-Baroni G, 2011, LIVER INT, V31, P1285, DOI 10.1111/j.1478-3231.2011.02462.x
   Syed-Abdul MM, 2020, HEPATOLOGY, V72, P103, DOI 10.1002/hep.31000
   Takase T, 2017, ENDOCR J, V64, P363, DOI 10.1507/endocrj.EJ16-0295
   Tang A, 2015, DIABETES CARE, V38, P1339, DOI 10.2337/dc14-2548
   Thaiss CA, 2018, SCIENCE, V359, P1376, DOI 10.1126/science.aar3318
   Thomas C, 2008, NAT REV DRUG DISCOV, V7, P678, DOI 10.1038/nrd2619
   Tilg H, 2010, HEPATOLOGY, V52, P1836, DOI 10.1002/hep.24001
   Tillner J, 2019, DIABETES OBES METAB, V21, P120, DOI 10.1111/dom.13494
   Tobita H, 2017, CURR THER RES CLIN E, V87, P13, DOI 10.1016/j.curtheres.2017.07.002
   Tolhurst G, 2012, DIABETES, V61, P364, DOI 10.2337/db11-1019
   Trauner M, 2019, HEPATOLOGY, V70, P788, DOI 10.1002/hep.30509
   Trauner M, 2017, HEPATOLOGY, V65, P1393, DOI 10.1002/hep.28991
   Trevaskis JL, 2012, AM J PHYSIOL-GASTR L, V302, pG762, DOI 10.1152/ajpgi.00476.2011
   Tully DC, 2017, J MED CHEM, V60, P9960, DOI 10.1021/acs.jmedchem.7b00907
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Ueda SY, 2009, J ENDOCRINOL, V203, P357, DOI 10.1677/JOE-09-0190
   Vahl TP, 2007, ENDOCRINOLOGY, V148, P4965, DOI 10.1210/en.2006-0153
   Valdecantos MP, 2017, HEPATOLOGY, V65, P950, DOI 10.1002/hep.28962
   Vandanmagsar B, 2011, NAT MED, V17, P179, DOI 10.1038/nm.2279
   Vilsboll T, 2003, REGUL PEPTIDES, V114, P115, DOI 10.1016/S0167-0115(03)00111-3
   Vilsboll T, 2003, J CLIN ENDOCR METAB, V88, P2706, DOI 10.1210/jc.2002-021873
   Vilsboll T, 2012, BMJ-BRIT MED J, V344, DOI 10.1136/bmj.d7771
   Volynets V, 2012, DIGEST DIS SCI, V57, P1932, DOI 10.1007/s10620-012-2112-9
   Vrieze A, 2012, GASTROENTEROLOGY, V143, P913, DOI 10.1053/j.gastro.2012.06.031
   Wang WL, 2000, J CELL SCI, V113, P4435
   Watanabe T, 2015, J DIABETES INVEST, V6, P164, DOI 10.1111/jdi.12262
   WEI Y, 1995, FEBS LETT, V358, P219, DOI 10.1016/0014-5793(94)01430-9
   Whyte MB, 2019, J CLIN ENDOCR METAB, V104, P359, DOI 10.1210/jc.2018-01176
   Wirth R, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0110440
   Wree A, 2014, J MOL MED, V92, P1069, DOI 10.1007/s00109-014-1170-1
   Xie GX, 2016, INT J CANCER, V139, P1764, DOI 10.1002/ijc.30219
   Xie GX, 2016, ONCOTARGET, V7, P19355, DOI 10.18632/oncotarget.8466
   Xue YS, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0168670
   Yaghoubi M, 2017, EUR J GASTROEN HEPAT, V29, P1385, DOI 10.1097/MEG.0000000000000981
   Yan JH, 2019, HEPATOLOGY, V69, P2414, DOI 10.1002/hep.30320
   Yan XF, 2016, J DIABETES RES, V2016, DOI 10.1155/2016/2093171
   Yang F, 2007, CANCER RES, V67, P863, DOI 10.1158/0008-5472.CAN-06-1078
   Yilmaz Y, 2012, ACTA GASTRO-ENT BELG, V75, P240
   Yokote K, 2020, DIABETES OBES METAB, V22, P1102, DOI 10.1111/dom.14006
   Yoshimoto S, 2013, NATURE, V499, P97, DOI 10.1038/nature12347
   You S., 2016, DIABETES S1, V65, pA221, DOI [10.2337/db16-861-1374, DOI 10.2337/DB16-861-1374]
   Younossi Z, 2019, HEPATOLOGY, V69, P2672, DOI 10.1002/hep.30251
   Younossi ZM, 2019, LANCET, V394, P2184, DOI 10.1016/S0140-6736(19)33041-7
   Yu LX, 2010, HEPATOLOGY, V52, P1322, DOI 10.1002/hep.23845
   Zaki MH, 2010, IMMUNITY, V32, P379, DOI 10.1016/j.immuni.2010.03.003
   Zhang LL, 2013, LIVER INT, V33, P794, DOI 10.1111/liv.12120
   Zhang Q, 2018, EXP BIOL MED, V243, P34, DOI 10.1177/1535370217743765
   Zhang Q, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0184735
   Zhou M, 2019, J LIPID RES, V60, P550, DOI 10.1194/jlr.M089961
   Zhou M, 2017, HEPATOL COMMUN, V1, P1024, DOI 10.1002/hep4.1108
   Zhou M, 2017, J HEPATOL, V66, P1182, DOI 10.1016/j.jhep.2017.01.027
   Zhou M, 2017, NAT COMMUN, V8, DOI 10.1038/ncomms15433
   Zhou M, 2014, CANCER RES, V74, P3306, DOI 10.1158/0008-5472.CAN-14-0208
   Zhou ZY, 2016, ACTA PHARMACOL SIN, V37, P1063, DOI 10.1038/aps.2016.21
   Zhu LX, 2013, HEPATOLOGY, V57, P601, DOI 10.1002/hep.26093
NR 313
TC 27
Z9 28
U1 1
U2 14
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD AUG
PY 2020
VL 21
IS 16
AR 5820
DI 10.3390/ijms21165820
PG 39
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA NI0SG
UT WOS:000565068500001
PM 32823659
OA Green Submitted, gold, Green Published
DA 2023-06-08
ER

PT J
AU Tanase, DM
   Gosav, EM
   Costea, CF
   Ciocoiu, M
   Lacatusu, CM
   Maranduca, MA
   Ouatu, A
   Floria, M
AF Tanase, Daniela Maria
   Gosav, Evelina Maria
   Costea, Claudia Florida
   Ciocoiu, Manuela
   Lacatusu, Cristina Mihaela
   Maranduca, Minela Aida
   Ouatu, Anca
   Floria, Mariana
TI The Intricate Relationship between Type 2 Diabetes Mellitus (T2DM),
   Insulin Resistance (IR), and Nonalcoholic Fatty Liver Disease (NAFLD)
SO JOURNAL OF DIABETES RESEARCH
LA English
DT Review
ID RANDOMIZED CONTROLLED-TRIAL; ADIPOSE-TISSUE MACROPHAGES; RECEPTOR-BETA
   AGONIST; GUT MICROBIOTA; VITAMIN-E; SYSTEMIC METABOLISM; OXIDATIVE
   STRESS; NATURAL-HISTORY; HEPATIC FAT; METFORMIN
AB Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) remain as one of the most global problematic metabolic diseases with rapidly increasing prevalence and incidence. Epidemiological studies noted that T2DM patients have by two-fold increase to develop NAFLD, and vice versa. This complex and intricate association is supported and mediated by insulin resistance (IR). In this review, we discuss the NAFLD immunopathogenesis, connection with IR and T2DM, the role of screening and noninvasive tools, and mostly the impact of the current antidiabetic drugs on steatosis liver and new potential therapeutic targets.
C1 [Tanase, Daniela Maria; Gosav, Evelina Maria; Ouatu, Anca; Floria, Mariana] Grigore T Popa Univ Med & Pharm, Dept Internal Med, Iasi, Romania.
   [Tanase, Daniela Maria; Gosav, Evelina Maria; Ouatu, Anca] Sf Spiridon Cty Clin Emergency Hosp, Internal Med Clin, Iasi, Romania.
   [Costea, Claudia Florida] Grigore T Popa Univ Med & Pharm, Dept Ophthalmol, Iasi, Romania.
   [Costea, Claudia Florida] Prof Dr Nicolae Oblu Emergency Clin Hosp, Ophthalmol Clin 2, Iasi, Romania.
   [Ciocoiu, Manuela] Grigore T Popa Univ Med & Pharm, Fac Med, Dept Pathophysiol, Iasi, Romania.
   [Lacatusu, Cristina Mihaela] Grigore T Popa Univ Med & Pharm, Unit Diabet Nutr & Metab Dis, Iasi, Romania.
   [Lacatusu, Cristina Mihaela] Sf Spiridon Cty Clin Emergency Hosp, Clin Ctr Diabet Nutr & Metab Dis, Iasi, Romania.
   [Maranduca, Minela Aida] Grigore T Popa Univ Med & Pharm, Dept Physiol, Iasi, Romania.
   [Floria, Mariana] Emergency Mil Clin Hosp, Internal Med Clin, Iasi, Romania.
C3 Grigore T Popa University of Medicine & Pharmacy; Grigore T Popa
   University of Medicine & Pharmacy; Grigore T Popa University of Medicine
   & Pharmacy; Grigore T Popa University of Medicine & Pharmacy; Grigore T
   Popa University of Medicine & Pharmacy
RP Gosav, EM (通讯作者)，Grigore T Popa Univ Med & Pharm, Dept Internal Med, Iasi, Romania.; Gosav, EM (通讯作者)，Sf Spiridon Cty Clin Emergency Hosp, Internal Med Clin, Iasi, Romania.
EM dr.evelinagosav@yahoo.com
RI Evelina Maria, Gosav/AAG-9695-2019; TANASE, DANIELA MARIA/AAS-7126-2020;
   Floria, Mariana/AAE-7193-2021; Costea, Claudia Florida/AAL-4352-2020;
   Lacatusu, Cristina Mihaela/AAE-5515-2022; Maranduca, Minela
   Aida/ABI-8354-2020; Mariana, Floria/A-3072-2017
OI Evelina Maria, Gosav/0000-0003-1730-9306; Costea, Claudia
   Florida/0000-0002-2488-2154; Lacatusu, Cristina
   Mihaela/0000-0002-9012-5901; Mariana, Floria/0000-0002-9465-1503; Ouatu,
   Anca/0000-0001-8923-8194; Tanase, Daniela Maria/0000-0002-7144-2506
CR Akazawa Y, 2018, J GASTROENTEROL, V53, P893, DOI 10.1007/s00535-018-1451-5
   Akbal E, 2016, WIEN KLIN WOCHENSCHR, V128, P48, DOI 10.1007/s00508-014-0680-8
   Akuta N, 2020, INTERNAL MED, V59, P329, DOI 10.2169/internalmedicine.3555-19
   Akuta N, 2019, HEPATOL RES, V49, P531, DOI 10.1111/hepr.13304
   Akuta N, 2017, HEPATOL COMMUN, V1, P46, DOI 10.1002/hep4.1019
   Alisi A, 2017, MEDIAT INFLAMM, V2017, DOI 10.1155/2017/8162421
   Alkhouri N, 2020, EXPERT OPIN INV DRUG, V29, P135, DOI 10.1080/13543784.2020.1668374
   Amano SU, 2014, CELL METAB, V19, P162, DOI 10.1016/j.cmet.2013.11.017
   Amer Diabet Assoc, 2018, DIABETES CARE, V41, pS73, DOI 10.2337/dc18-S008
   Amer Diabet Assoc, 2009, DIABETES CARE, V32, pS62, DOI [10.2337/dc11-S011, 10.2337/dc09-S062, 10.2337/dc19-S002, 10.2337/dc18-S002, 10.2337/dc12-S064]
   American Diabetes Association, 2020, Diabetes Care, V43, pS37, DOI 10.2337/dc20-S004
   Amod A, 2020, DIABETES THER, V11, P53, DOI [10.1007/s13300-019-00715-x, 10.2337/dci19-0066]
   Ampuero J, 2020, CLIN GASTROENTEROL H, V18, P216, DOI 10.1016/j.cgh.2019.05.051
   Anania C, 2018, WORLD J GASTROENTERO, V24, P2083, DOI 10.3748/wjg.v24.i19.2083
   [Anonymous], 2018, J HEPATOL, V69, P1197, DOI 10.1016/j.jhep.2018.02.013
   Apostolopoulou M, 2018, DIABETES CARE, V41, P1235, DOI 10.2337/dc17-1318
   Arab JP, 2018, ANNU REV PATHOL-MECH, V13, P321, DOI 10.1146/annurev-pathol-020117-043617
   Aragones G, 2020, INT J OBESITY, V44, P875, DOI 10.1038/s41366-019-0430-0
   Armstrong MJ, 2016, J HEPATOL, V64, P399, DOI 10.1016/j.jhep.2015.08.038
   Armstrong MJ, 2016, LANCET, V387, P679, DOI 10.1016/S0140-6736(15)00803-X
   Augustyn M, 2019, CLIN EXP HEPATOL, V5, P1, DOI 10.5114/ceh.2019.83151
   Ballestri S, 2016, J GASTROEN HEPATOL, V31, P936, DOI 10.1111/jgh.13264
   Bedogni G, 2006, BMC GASTROENTEROL, V6, DOI 10.1186/1471-230X-6-33
   Bellentani S, 2017, LIVER INT, V37, P81, DOI 10.1111/liv.13299
   Benedict M, 2017, WORLD J HEPATOL, V9, P715, DOI 10.4254/wjh.v9.i16.715
   Bergman RN, 2019, DIABETES, V68, P1709, DOI 10.2337/db19-0098
   Bertot LC, 2018, LIVER INT, V38, P1793, DOI 10.1111/liv.13739
   Bhat A, 2015, WORLD J HEPATOL, V7, P1652, DOI 10.4254/wjh.v7.i12.1652
   Birkenfeld AL, 2014, HEPATOLOGY, V59, P713, DOI 10.1002/hep.26672
   Bizino MB, 2020, DIABETOLOGIA, V63, P65, DOI 10.1007/s00125-019-05021-6
   Bomhof MR, 2019, EUR J NUTR, V58, P1735, DOI 10.1007/s00394-018-1721-2
   Bonnet F, 2017, J HYPERTENS, V35, P493, DOI 10.1097/HJH.0000000000001204
   Boutari C, 2020, METABOLISM, V103, DOI 10.1016/j.metabol.2019.154028
   Boyraz M, 2015, J CLIN RES PEDIATR E, V7, P121, DOI 10.4274/jcrpe.1749
   Brar G, 2019, J GASTROENTEROL, V54, P218, DOI 10.1007/s00535-018-01542-w
   Brouwers MCGJ, 2020, DIABETOLOGIA, V63, P253, DOI 10.1007/s00125-019-05024-3
   Bugianesi E, 2016, J HEPATOL, V65, P643, DOI 10.1016/j.jhep.2016.05.038
   Bugianesi E, 2005, AM J GASTROENTEROL, V100, P1082, DOI 10.1111/j.1572-0241.2005.41583.x
   Bullon-Vela V, 2020, NUTRITION, V71, DOI 10.1016/j.nut.2019.110620
   Byrne CD, 2020, J HEPATOL, V72, P785, DOI 10.1016/j.jhep.2020.01.013
   Campo L, 2019, J CLIN TRANSL HEPATO, V7, P56, DOI 10.14218/JCTH.2018.00008
   Caussy C, 2018, HEPATOLOGY, V67, P1348, DOI 10.1002/hep.29639
   Chalasani NP, 2017, HEPATOLOGY, V66, p303A
   Chavez-Carbajal A, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20020438
   Chiang H, 2020, BRIT J PHARMACOL, V177, P239, DOI 10.1111/bph.14859
   Cho Y. E., 2019, HEPATOLOGY, V10, DOI [10.1002/hep.30652, DOI 10.1002/HEP.306522-S2.0-85066472298]
   Coats BR, 2017, CELL REP, V20, P3149, DOI 10.1016/j.celrep.2017.08.096
   Coccia F, 2020, NUTR METAB CARDIOVAS, V30, P106, DOI 10.1016/j.numecd.2019.08.001
   Cusi K, 2017, DIABETES OBES METAB, V19, P1630, DOI 10.1111/dom.12973
   Cusi K, 2016, ANN INTERN MED, V165, P305, DOI 10.7326/M15-1774
   Daemen S, 2020, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.03133
   Dai WJ, 2017, MEDICINE, V96, DOI 10.1097/MD.0000000000008179
   Devan Shakthi R. K., 2018, Journal of Basic and Clinical Physiology and Pharmacology, V29, P553, DOI 10.1515/jbcpp-2017-0030
   Dibba Pratima, 2018, Diseases, V6, DOI 10.3390/diseases6030083
   Drummen M, 2018, AM J PHYSIOL-ENDOC M, V315, pE885, DOI 10.1152/ajpendo.00162.2018
   Dubois V, 2017, J CLIN INVEST, V127, P1202, DOI 10.1172/JCI88894
   Eddowes PJ, 2019, GASTROENTEROLOGY, V156, P1717, DOI 10.1053/j.gastro.2019.01.042
   Eguchi Y, 2015, HEPATOL RES, V45, P269, DOI 10.1111/hepr.12351
   Enooku K, 2018, J GASTROENTEROL, V53, P1261, DOI 10.1007/s00535-018-1472-0
   Eriksson JW, 2018, DIABETOLOGIA, V61, P1923, DOI 10.1007/s00125-018-4675-2
   Errazuriz I, 2017, J CLIN ENDOCR METAB, V102, P1765, DOI 10.1210/jc.2016-3722
   Ertunc ME, 2016, J LIPID RES, V57, P2099, DOI 10.1194/jlr.R066514
   Eslam M, 2020, NAT REV GASTRO HEPAT, V17, P40, DOI 10.1038/s41575-019-0212-0
   Forlani G, 2016, J DIABETES RES, V2016, DOI 10.1155/2016/2931985
   Francque S, 2019, ADV THER, V36, P1052, DOI 10.1007/s12325-019-00898-6
   Frias JP, 2016, LANCET DIABETES ENDO, V4, P1004, DOI 10.1016/S2213-8587(16)30267-4
   Friedman SL, 2018, NAT MED, V24, P908, DOI 10.1038/s41591-018-0104-9
   Friedman SL, 2018, HEPATOLOGY, V67, P1754, DOI 10.1002/hep.29477
   Fujimori N, 2020, CLIN J GASTROENTEROL, V13, P83, DOI 10.1007/s12328-019-01018-1
   Fujita Y, 2014, J DIABETES INVEST, V5, P265, DOI 10.1111/jdi.12214
   Fujiwara N, 2020, HEPATOL RES, V50, P817, DOI 10.1111/hepr.13506
   Galmes-Pascual BM, 2020, FREE RADICAL BIO MED, V150, P148, DOI 10.1016/j.freeradbiomed.2020.02.016
   Gambino R, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17040479
   Gastaldelli A, 2020, DIABETES OBES METAB, V22, P393, DOI 10.1111/dom.13907
   Gastaldelli A, 2017, DIABETES, V66, P815, DOI 10.2337/db16-1167
   Gonzalez-Muniesa P, 2017, NAT REV DIS PRIMERS, V3, DOI 10.1038/nrdp.2017.34
   Guillaume M, 2019, ALIMENT PHARM THER, V50, P1214, DOI 10.1111/apt.15529
   Guillot A, 2019, HEPATOL COMMUN, V3, P730, DOI 10.1002/hep4.1356
   Hao YR, 2018, BIOCHEM BIOPH RES CO, V503, P564, DOI 10.1016/j.bbrc.2018.05.187
   Hari Kumar K V S, 2020, Med J Armed Forces India, V76, P4, DOI 10.1016/j.mjafi.2019.07.001
   Harrison S, 2018, J HEPATOL, V68, pS38, DOI 10.1016/S0168-8278(18)30292-7
   Hazlehurst JM, 2016, METABOLISM, V65, P1096, DOI 10.1016/j.metabol.2016.01.001
   He L, 2016, NUTRIENTS, V8, DOI 10.3390/nu8040215
   He L, 2009, CELL, V137, P635, DOI 10.1016/j.cell.2009.03.016
   He YN, 2020, ANN HEPATOL, V19, P44, DOI 10.1016/j.aohep.2019.06.023
   Hedjazifar S, 2020, DIABETES, V69, P331, DOI 10.2337/db19-0701
   Heymann F, 2015, HEPATOLOGY, V62, P279, DOI 10.1002/hep.27793
   Hill DA, 2018, P NATL ACAD SCI USA, V115, pE5096, DOI 10.1073/pnas.1802611115
   Hodson L, 2020, P NUTR SOC, V79, P30, DOI 10.1017/S0029665119000569
   Hong SH, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21020494
   Hu HM, 2020, J GASTROENTEROL, V55, P142, DOI 10.1007/s00535-019-01649-8
   Huang JF, 2020, J FORMOS MED ASSOC, V119, P89, DOI 10.1016/j.jfma.2019.03.014
   Huang W, 2010, DIABETES, V59, P347, DOI 10.2337/db09-0016
   Hudec M, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21083005
   Ipsen DH, 2018, CELL MOL LIFE SCI, V75, P3313, DOI 10.1007/s00018-018-2860-6
   Isokuortti E, 2017, DIABETOLOGIA, V60, P1873, DOI 10.1007/s00125-017-4340-1
   Ito D, 2017, DIABETES CARE, V40, P1364, DOI 10.2337/dc17-0518
   Jabbour S, 2018, DIABETES, V67, DOI 10.2337/db18-104-LB
   Jabbour SA, 2018, DIABETES CARE, V41, P2136, DOI 10.2337/dc18-0680
   Jager J, 2016, J INTERN MED, V280, P209, DOI 10.1111/joim.12483
   Jain MR, 2018, LIVER INT, V38, P1084, DOI 10.1111/liv.13634
   Jimoh A, 2018, Pathophysiology, V25, P359, DOI 10.1016/j.pathophys.2018.07.003
   Johnson AR, 2016, MOL METAB, V5, P506, DOI 10.1016/j.molmet.2016.04.005
   Kahn CE, 2000, COMPUT METH PROG BIO, V63, P85, DOI 10.1016/S0169-2607(00)00079-1
   Kahn CR, 2000, J CLIN INVEST, V106, P1305, DOI 10.1172/JCI11705
   Kalavalapalli S, 2018, AM J PHYSIOL-ENDOC M, V315, pE163, DOI 10.1152/ajpendo.00023.2018
   Kanwal F, 2018, GASTROENTEROLOGY, V155, P1828, DOI 10.1053/j.gastro.2018.08.024
   Kawano Y, 2013, J GASTROENTEROL, V48, P434, DOI 10.1007/s00535-013-0758-5
   Kazankov K, 2019, NAT REV GASTRO HEPAT, V16, P145, DOI 10.1038/s41575-018-0082-x
   Khoo J, 2019, LIVER INT, V39, P941, DOI 10.1111/liv.14065
   Kim SJ, 2019, HEPATOLOGY, V69, P1965, DOI 10.1002/hep.30525
   Kim YS, 2020, METABOLISM, V103, DOI 10.1016/j.metabol.2019.154026
   Kitade H, 2017, NUTRIENTS, V9, DOI 10.3390/nu9040387
   Kleinert M, 2018, NAT REV ENDOCRINOL, V14, P140, DOI 10.1038/nrendo.2017.161
   Koo BK, 2020, J VASC SURG, V71, P204, DOI 10.1016/j.jvs.2019.03.044
   Koutny F, 2020, PEDIATR OBES, V15, DOI 10.1111/ijpo.12601
   Koutoukidis DA, 2019, JAMA INTERN MED, V179, P1262, DOI 10.1001/jamainternmed.2019.2248
   Krenkel O, 2018, HEPATOLOGY, V67, P1270, DOI 10.1002/hep.29544
   Krenkel O, 2017, NAT REV IMMUNOL, V17, P306, DOI 10.1038/nri.2017.11
   Krishan S, 2016, DIABETES METAB SYND, V10, pS77, DOI 10.1016/j.dsx.2016.01.034
   Krishnan S, 2019, CELL REP, V28, P3285, DOI 10.1016/j.celrep.2019.08.080
   Kuchay MS, 2018, DIABETES CARE, V41, P1801, DOI 10.2337/dc18-0165
   Kwok R, 2016, GUT, V65, P1359, DOI 10.1136/gutjnl-2015-309265
   Lai LL, 2020, DIGEST DIS SCI, V65, P623, DOI 10.1007/s10620-019-5477-1
   Lavine JE, 2011, JAMA-J AM MED ASSOC, V305, P1659, DOI 10.1001/jama.2011.520
   Lawitz EJ, 2018, CLIN GASTROENTEROL H, V16, P1983, DOI 10.1016/j.cgh.2018.04.042
   Le P, 2020, EXPERT OPIN INV DRUG, V29, P205, DOI 10.1080/13543784.2020.1704731
   Lefere S, 2019, JHEP REP, V1, P30, DOI 10.1016/j.jhepr.2019.02.004
   Li G, 2018, EUR NEUROPSYCHOPHARM, V28, P892, DOI 10.1016/j.euroneuro.2018.05.015
   Li J, 2019, LANCET GASTROENTEROL, V4, P389, DOI 10.1016/S2468-1253(19)30039-1
   Li LJ, 2019, METABOLISM, V91, P30, DOI 10.1016/j.metabol.2018.11.003
   Li M, 2018, GUT, V67, P2169, DOI 10.1136/gutjnl-2017-313778
   Li Y, 2020, BMJ OPEN DIAB RES CA, V8, DOI 10.1136/bmjdrc-2019-000724
   Lindenmeyer CC, 2018, CLIN LIVER DIS, V22, P11, DOI 10.1016/j.cld.2017.08.003
   Liu WS, 2016, CELL MOL LIFE SCI, V73, P1969, DOI 10.1007/s00018-016-2161-x
   Lombardi R, 2020, LIVER INT, V40, P347, DOI 10.1111/liv.14274
   Loomba R, 2009, ALIMENT PHARM THER, V29, P172, DOI 10.1111/j.1365-2036.2008.03869.x
   Loomba R, 2019, J HEPATOL, V70, pE150, DOI 10.1016/S0618-8278(19)30266-X
   Lu YC, 2020, INT J MED SCI, V17, P182, DOI 10.7150/ijms.40417
   Luukkonen PK, 2018, DIABETES CARE, V41, P1732, DOI 10.2337/dc18-0071
   Machado MV, 2016, GASTROENTEROLOGY, V150, P1769, DOI 10.1053/j.gastro.2016.02.066
   Mann JP, 2018, SEMIN LIVER DIS, V38, P1, DOI 10.1055/s-0038-1627456
   Marchesini G, 2017, J HEPATOL, V66, P466, DOI 10.1016/j.jhep.2016.11.002
   Marra F, 2018, J HEPATOL, V68, P280, DOI 10.1016/j.jhep.2017.11.014
   Masarone M, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/9547613
   Mayer-Davis EJ, 2018, PEDIATR DIABETES, V19, P7, DOI 10.1111/pedi.12773
   Mazidi M, 2019, J AM COLL NUTR, V38, P633, DOI 10.1080/07315724.2018.1507011
   Mendez-Sanchez N, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19072034
   Mikami K, 2020, CYTOKINE, V126, DOI 10.1016/j.cyto.2019.154927
   Mikolasevic I, 2018, WORLD J GASTROENTERO, V24, P1491, DOI 10.3748/wjg.v24.i14.1491
   Milosevic N, 2020, ENVIRON SCI POLLUT R, V27, P772, DOI 10.1007/s11356-019-06831-2
   Monteillet L, 2018, MOL METAB, V16, P100, DOI 10.1016/j.molmet.2018.07.006
   Morgantini C, 2019, NAT METAB, V1, P445, DOI 10.1038/s42255-019-0044-9
   Oishi Y, 2017, CELL METAB, V25, P412, DOI 10.1016/j.cmet.2016.11.009
   Ozaki A, 2020, CONT CLIN TRIAL COMM, V17, DOI 10.1016/j.conctc.2019.100516
   Parker R, 2018, AM J PHYSIOL-GASTR L, V314, pG483, DOI 10.1152/ajpgi.00213.2017
   Patel PJ, 2020, CLIN GASTROENTEROL H, V18, P710, DOI 10.1016/j.cgh.2019.07.036
   Patterson RE, 2017, ANNU REV NUTR, V37, P371, DOI 10.1146/annurev-nutr-071816-064634
   Perry RJ, 2014, NATURE, V510, P84, DOI 10.1038/nature13478
   Petit JM, 2017, J CLIN ENDOCR METAB, V102, P407, DOI 10.1210/jc.2016-2775
   Pettinelli P, 2009, BBA-MOL BASIS DIS, V1792, P1080, DOI 10.1016/j.bbadis.2009.08.015
   Pimpin L, 2018, J HEPATOL, V69, P718, DOI 10.1016/j.jhep.2018.05.011
   Poynard T, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0030325
   Prat LI, 2018, HORM-INT J ENDOCRINO, V17, P219, DOI 10.1007/s42000-018-0021-9
   Raj H, 2019, WORLD J DIABETES, V10, P114, DOI 10.4239/wjd.v10.i2.114
   Ratziu V, 2008, GASTROENTEROLOGY, V135, P100, DOI 10.1053/j.gastro.2008.03.078
   Ratziu V, 2016, GASTROENTEROLOGY, V150, P1147, DOI 10.1053/j.gastro.2016.01.038
   Ratziu V, 2010, HEPATOLOGY, V51, P445, DOI 10.1002/hep.23270
   Reimer KC, 2020, HEPATOL INT, V14, P8, DOI 10.1007/s12072-019-10001-4
   Ren WK, 2019, ADV NUTR, V10, P321, DOI 10.1093/advances/nmy084
   Rodriguez-Ramiro I, 2016, P NUTR SOC, V75, P47, DOI 10.1017/S0029665115004218
   Romero-Gomez M, 2017, J HEPATOL, V67, P829, DOI 10.1016/j.jhep.2017.05.016
   Rowland I, 2018, EUR J NUTR, V57, P1, DOI 10.1007/s00394-017-1445-8
   Runge JH, 2018, RADIOLOGY, V286, P547, DOI 10.1148/radiol.2017162931
   Sakai M, 2019, IMMUNITY, V51, P655, DOI 10.1016/j.immuni.2019.09.002
   Sanyal A, 2018, LANCET, V392, P2705, DOI 10.1016/S0140-6736(18)31785-9
   Sanyal AJ, 2010, NEW ENGL J MED, V362, P1675, DOI 10.1056/NEJMoa0907929
   Sattari M, 2020, J INVEST MED, V68, P743, DOI 10.1136/jim-2019-001186
   Schernthaner-Reiter MH, 2017, ENDOCRIN METAB CLIN, V46, P305, DOI 10.1016/j.ecl.2017.01.002
   Scorletti E, 2018, CONTEMP CLIN TRIALS, V71, P113, DOI 10.1016/j.cct.2018.05.010
   Seko Y, 2017, HEPATOL RES, V47, P1072, DOI 10.1111/hepr.12834
   Sellmann C, 2017, J NUTR, V147, P2041, DOI 10.3945/jn.117.253815
   Shi DM, 2019, FRONT PHYSIOL, V10, DOI 10.3389/fphys.2019.00423
   Shibuya T, 2018, DIABETES OBES METAB, V20, P438, DOI 10.1111/dom.13061
   Shimizu M, 2019, DIABETES OBES METAB, V21, P285, DOI 10.1111/dom.13520
   Shoshtari-Yeganeh B, 2019, ENVIRON SCI POLLUT R, V26, P9435, DOI 10.1007/s11356-019-04373-1
   Skytte MJ, 2019, DIABETOLOGIA, V62, P2066, DOI 10.1007/s00125-019-4956-4
   Smith GI, 2020, J CLIN INVEST, V130, P1453, DOI 10.1172/JCI134165
   Solinas G, 2017, MOL METAB, V6, DOI 10.1016/j.molmet.2016.12.001
   Cruz EMS, 2020, BIOL OPEN, V9, DOI 10.1242/bio.047282
   Strey CBM, 2018, ANN HEPATOL, V17, P585, DOI 10.5604/01.3001.0012.0922
   Sumida Y, 2019, HEPATOL RES, V49, P64, DOI 10.1111/hepr.13236
   Sung KC, 2013, J CLIN ENDOCR METAB, V98, P3637, DOI 10.1210/jc.2013-1519
   Tan HY, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/2795090
   Taylor R, 2018, CELL METAB, V28, P547, DOI 10.1016/j.cmet.2018.07.003
   Thondam SK, 2020, PEPTIDES, V125, DOI 10.1016/j.peptides.2019.170208
   Tuccori M, 2016, BMJ-BRIT MED J, V352, DOI 10.1136/bmj.i1541
   Valenti L, 2016, LIVER INT, V36, P1563, DOI 10.1111/liv.13185
   Van Herck MA, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.00082
   Verboven K, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-22962-x
   Verma M, 2017, BIOORG CHEM, V70, P267, DOI 10.1016/j.bioorg.2016.12.004
   Vijayakumar A, 2017, CELL REP, V21, P1021, DOI 10.1016/j.celrep.2017.09.091
   Wentworth JM, 2010, DIABETES, V59, P1648, DOI 10.2337/db09-0287
   Wild SH, 2018, DIABETES CARE, V41, P341, DOI 10.2337/dc17-1590
   Win S, 2018, HEPATOLOGY, V67, P2013, DOI 10.1002/hep.29689
   Wong VWS, 2016, J HEPATOL, V64, P1211, DOI 10.1016/j.jhep.2016.02.032
   Xia JY, 2015, CELL METAB, V22, P266, DOI 10.1016/j.cmet.2015.06.007
   Yan JH, 2019, HEPATOLOGY, V69, P2414, DOI 10.1002/hep.30320
   Yi M, 2017, DIABETIC MED, V34, P505, DOI 10.1111/dme.13174
   Younossi Z, 2018, NAT REV GASTRO HEPAT, V15, P11, DOI 10.1038/nrgastro.2017.109
   Younossi ZM, 2019, J HEPATOL, V71, P793, DOI 10.1016/j.jhep.2019.06.021
   Younossi Zobair M, 2018, Clin Liver Dis (Hoboken), V11, P92, DOI 10.1002/cld.710
   Younossi ZM, 2015, HEPATOLOGY, V62, P1723, DOI 10.1002/hep.28123
   Zhang XT, 2017, J DIABETES RES, V2017, DOI 10.1155/2017/5281358
   Zheng C, 2016, CELL DEATH DIS, V7, DOI 10.1038/cddis.2016.54
NR 216
TC 98
Z9 103
U1 13
U2 42
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6745
EI 2314-6753
J9 J DIABETES RES
JI J. Diabetes Res.
PD AUG 4
PY 2020
VL 2020
AR 3920196
DI 10.1155/2020/3920196
PG 16
WC Endocrinology & Metabolism; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Research & Experimental Medicine
GA NF8RD
UT WOS:000563559400002
PM 32832560
OA gold, Green Published
DA 2023-06-08
ER

PT J
AU Nier, A
   Engstler, AJ
   Maier, IB
   Bergheim, I
AF Nier, Anika
   Engstler, Anna Janina
   Maier, Ina Barbara
   Bergheim, Ina
TI Markers of intestinal permeability are already altered in early stages
   of non-alcoholic fatty liver disease: Studies in children
SO PLOS ONE
LA English
DT Article
ID LIPOPOLYSACCHARIDE-BINDING PROTEIN; PLASMINOGEN-ACTIVATOR INHIBITOR-1;
   FRUCTOSE-INDUCED STEATOSIS; MICE ROLE; CD14; ULTRASONOGRAPHY;
   ASSOCIATION; ENDOTOXEMIA; METFORMIN; CIRRHOSIS
AB Background & aims
   Recent studies have shown that patients with manifest non-alcoholic fatty liver disease (NAFLD), e.g. steatosis grade 3 or steatohepatitis with or without beginning fibrosis frequently show altered fecal microbiota composition and elevated bacterial endotoxin levels. However, if these alterations are signs of a progressing disease or are already found in initial disease stages has not yet been clarified.
   Methods
   Twenty children with simple steatosis (grade 1) diagnosed by ultrasound and 29 normal weight healthy control children (age < 10 years) were included in the study (mean age 7.6 +/- 1.1 years). Metabolic parameters, markers of intestinal barrier function and inflammation were determined.
   Results
   Activity of alanine aminotransferase, concentrations of some markers of inflammation and insulin resistance were significantly higher in plasma of NAFLD children than in controls. When compared to controls, plasma bacterial endotoxin and lipopolysaccharide-binding protein (LBP) levels were significantly higher in NAFLD children (+ 50% and + 24%, respectively), while soluble CD14 serum and D-lactate plasma levels as well as the prevalence of small intestinal bacterial overgrowth did not differ between groups. Plasma endotoxin and LBP levels were positive associated with proinflammatory markers like plasminogen activator inhibitor-1, c-reactive protein, interleukin-6 and leptin while no associations with markers of insulin resistance were found.
   Conclusions
   Taken together, our results indicate that even in juvenile patients with early stages of NAFLD e.g. simple steatosis grade 1, plasma endotoxin concentrations are already elevated further suggesting that intestinal barrier dysfunction might be present already in the initial phases of the disease.
C1 [Nier, Anika; Engstler, Anna Janina; Bergheim, Ina] Univ Vienna, Dept Nutr Sci, Mol Nutr Sci, Vienna, Austria.
   [Nier, Anika; Engstler, Anna Janina; Bergheim, Ina] Friedrich Schiller Univ Jena, SD Model Syst Mol Nutr, Inst Nutr, Jena, Germany.
   [Maier, Ina Barbara] Univ Hohenheim, Dept Nutr Med, Stuttgart, Germany.
C3 University of Vienna; Friedrich Schiller University of Jena; University
   Hohenheim
RP Bergheim, I (通讯作者)，Univ Vienna, Dept Nutr Sci, Mol Nutr Sci, Vienna, Austria.; Bergheim, I (通讯作者)，Friedrich Schiller Univ Jena, SD Model Syst Mol Nutr, Inst Nutr, Jena, Germany.
EM ina.bergheim@univie.ac.at
OI Nier, Anika/0000-0003-3772-2261
FU German Ministry of Education and Science (BMBF) [FKZ: 01EA1305];
   University of Vienna
FX The work was supported in part by the German Ministry of Education and
   Science (BMBF), FKZ: 01EA1305 (IB). The funders did not have any
   additional role in the study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.; Open access
   funding provided by University of Vienna.
CR Agiasotelli D, 2017, LIVER INT, V37, P576, DOI 10.1111/liv.13264
   Akcam M, 2013, CLIN IMAG, V37, P504, DOI 10.1016/j.clinimag.2012.07.011
   Alisi A, 2010, J PEDIATR GASTR NUTR, V50, P645, DOI 10.1097/MPG.0b013e3181c7bdf1
   Anderson EL, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0140908
   Biedermann L, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0059260
   BODE C, 1987, J HEPATOL, V4, P8, DOI 10.1016/S0168-8278(87)80003-X
   Boursier J, 2016, HEPATOLOGY, V63, P764, DOI 10.1002/hep.28356
   Campbell DI, 2002, BRIT J NUTR, V88, P499, DOI 10.1079/BJN2002697
   Chen YY, 2014, J CHIN MED ASSOC, V77, P68, DOI 10.1016/j.jcma.2013.10.006
   de Courten B, 2016, MOL NUTR FOOD RES, V60, P103, DOI 10.1002/mnfr.201500102
   Engen PA, 2015, ALCOHOL RES-CURR REV, V37, P223
   Engstler AJ, 2016, GUT, V65, P1564, DOI 10.1136/gutjnl-2014-308379
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Feldstein AE, 2009, GUT, V58, P1538, DOI 10.1136/gut.2008.171280
   Guercio Nuzio S, 2016, PEDIAT OBES
   Harte AL, 2010, J INFLAMM-LOND, V7, DOI 10.1186/1476-9255-7-15
   Hernaez R, 2011, HEPATOLOGY, V54, P1082, DOI 10.1002/hep.24452
   Hocking MP, 1998, DIGEST DIS SCI, V43, P2493, DOI 10.1023/A:1026698602714
   Jin CJ, 2017, J GASTROEN HEPATOL, V32, P708, DOI 10.1111/jgh.13488
   JOSEPH AEA, 1991, CLIN RADIOL, V43, P26, DOI 10.1016/S0009-9260(05)80350-2
   Kanuri G, 2011, LAB INVEST, V91, P885, DOI 10.1038/labinvest.2011.44
   Kromeyer-Hauschild K, 2001, MONATSSCHR KINDERH, V149, P807, DOI 10.1007/s001120170107
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Maier IB, 2013, NUTR J, V12, DOI 10.1186/1475-2891-12-14
   Fernandez-Real JM, 2011, DIABETES, V60, P2179, DOI 10.2337/db10-1210
   Miele L, 2009, HEPATOLOGY, V49, P1877, DOI 10.1002/hep.22848
   Nardone G, 2010, AM J PHYSIOL-GASTR L, V299, pG669, DOI 10.1152/ajpgi.00188.2010
   Naska Androniki, 2017, F1000Res, V6, P926, DOI 10.12688/f1000research.10703.1
   Nobili V, 2016, ARCH MED SCI
   De Loera-Rodriguez CO, 2014, J INFLAMM-LOND, V11, DOI 10.1186/s12950-014-0039-y
   Papp M, 2012, LIVER INT, V32, P603, DOI 10.1111/j.1478-3231.2011.02689.x
   Ritze Y, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0101702
   Ruan Peng, 2004, Hepatobiliary Pancreat Dis Int, V3, P58
   Saad RJ, 2014, CLIN GASTROENTEROL H, V12, P1964, DOI 10.1016/j.cgh.2013.09.055
   Schafer C, 2002, ALCOHOL ALCOHOLISM, V37, P81, DOI 10.1093/alcalc/37.1.81
   Spruss A, 2012, LAB INVEST, V92, P1020, DOI 10.1038/labinvest.2012.75
   Thorgersen EB, 2010, FASEB J, V24, P712, DOI 10.1096/fj.09-140798
   Thuy S, 2008, J NUTR, V138, P1452, DOI 10.1093/jn/138.8.1452
   van den Berg EH, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0171502
   Velayudham A, 2009, HEPATOLOGY, V49, P989, DOI 10.1002/hep.22711
   Volynets V, 2013, EUR J NUTR, V52, P527, DOI 10.1007/s00394-012-0355-z
   Volynets V, 2010, J LIPID RES, V51, P3414, DOI 10.1194/jlr.M007179
   Wagnerberger S, 2013, J NUTR BIOCHEM, V24, P531, DOI 10.1016/j.jnutbio.2012.01.014
   Weiss J, 2014, DTSCH ARZTEBL INT, V111, P447, DOI 10.3238/arztebl.2014.0447
   Weiss R, 2004, NEW ENGL J MED, V350, P2362, DOI 10.1056/NEJMoa031049
   Younossi ZM, 2011, CLIN GASTROENTEROL H, V9, P524, DOI 10.1016/j.cgh.2011.03.020
   Zhu JZ, 2016, WORLD J GASTROENTERO, V22, P8226, DOI 10.3748/wjg.v22.i36.8226
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J9 PLOS ONE
JI PLoS One
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WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA FG0PY
UT WOS:000409467200015
PM 28880885
OA Green Published, Green Submitted, gold
DA 2023-06-08
ER


EF